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<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZU2</accession>
    <name>A0A2S5AZU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000152">
        <property type="protein sequence ID" value="POY70044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZU2"/>
    <dbReference type="STRING" id="741276.A0A2S5AZU2"/>
    <dbReference type="OrthoDB" id="128867at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="546" mass="59371" checksum="D3CA002379944A71" modified="2018-07-18" version="1">MSTAALDLPGFVYDPVRRRYFKATPSTAGRQTPAASAQTAQLVPQTRERHRQDVSDETPRQRKRGRAIGSGAVSDSVMDKLRNSHLAPWLTSTAARTVMKHDLQSRQMAHKLSSAMPPVYPDCLPMDDAIQHLSFDETDPATLRIGTSGGTIATGQLVRDEEERSMYPNDEQNWRTSWMCSSKITSLHTSKHRIVATCLGPPAQAIIGTTDDNISLASVTLSPRKTSLWSSAISRDLVVLGGDRSVLLTPLDSLSSSSSHPAGAGRSPALDSYTTGGRGGGGTVFALEIDEPGRMVWAGIRKGDVRGFDWRERRPSGGGGGQNSTHSEVTIPLGAPITHLRLIPRQPHQLLVAAMGGQLAIYDLRFLRAPTSSPRQEERSYRHIPKKSAAGRGILASSPAGRVVSTAPFSNSVPMPVVKMEGHENAYSTELGLDVWKDEWVAIAGQDSRLRIFSLRTGLALLPPNHPTAPASTLSTELTHPLARTFSGPIRSLAFSALDPYRLRESDYTRAILERDDERESTSRARWDCPSLWAADGPGVECFAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B039</accession>
    <name>A0A2S5B039_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="15" type="ORF">BMF94_6731</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B039"/>
    <dbReference type="STRING" id="741276.A0A2S5B039"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="14">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY70148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="481" mass="52988" checksum="6C7ED6AC7EA5BDDB" modified="2018-07-18" version="1">MSSILSERQKEELHKSILDYLQTNGYTETLNAFKGEADQPDFQPDPKAKWSGLLEKKWTSVIRLQKKIMDLESRNAQLTEELSSAPSKRPSASSPDWTPRAPARHTLSGHRMPITRVTFHPLFSQVVSASEDSTLKVWDWETGDFERTVKGHTKAVQDVDFDSKGNLLGMCGVRDPYGNASLMRAFSTVSCSSDLTIKLWDTNNDWKNIRTLHGHDHSISTARFLPTDDMIVSASRDRTIRVWEVSSGYCVKTISGHNDWIRSVLPSSDGALFISCSVDQTARIWDAQKGDTKSELRGHEHVVEAAVFAPIAAYSAIRELGGITMSASRAAEAKTVGQYAATGSRDKSIRIWDTSSGQCLKTLVGQPVRIQTQRSLSSVLFLLDDNWVRALVFHPSGKFLISASDDKTIRTWDLATGRCLKVLEAHNHFVTTLTWGRAKTAAGASLPNGTAAANGKASETAQVVNVVASGSVDQTIKIWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0D3</accession>
    <name>A0A2S5B0D3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0D3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0D3"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="239" mass="25636" checksum="5006A50D05CD73C8" modified="2018-07-18" version="1">MSTLAIVAGAGPGLGSALARSFGKHHAVAVLGRTVQTVEQVAEDVRKSGADATAFACDVTDPESVQETFDAIRKQWPSHQVKAALYNVNSPFLVKRFLETSLQDIKPGVDVNFYGAFHFSQKVLPLMLEGGGGFLGFTGATAALKGSAKFAALAPGKFALRGLAQNLAREFGPQGVHVSHVIVDGLIETDRVRGMMGEQKQADSRLDPEAIAETFLSLAQQPKNCWTHEVDVRPFSETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0P2</accession>
    <name>A0A2S5B0P2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6623</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0P2"/>
    <dbReference type="STRING" id="741276.A0A2S5B0P2"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="324"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="609" mass="67307" checksum="610D1C693F802D26" modified="2018-07-18" version="1">MKYILVSGGVISGIGKGVIASSTGLLLKTLGYNVTAIKIDPYMNIDAGTMSPTEHGKSFTCLEPGEVFVLDDGGEADLDLGNYERYLNVTLGKDNNITTGKIYREVIEKERRGDYLGKTVQVIPHVTNAIQDWVERVAQIPVDESGQAPEVCIIELGGTVGDIESAPFVEAMRQFQFRVGKDNFALLHVSLVPSINGELKTKPTQASIRDLRGLGLMPDLIACRCPAPLPLSVVEKISMFCHVGAEQVLAVHDVSSLYHVPLLLKDQGLVNFLQNRLRLDLIRPSDPRVARGAKLLTMWKDLTLSYDRLFDKVSICLVGKYTSLQDSYTSVIKSLEHAAMQCGRKLSITWVEASDLELEAQHVRPKEFHAAWQAVCTANGILVPGGFGLRGTEGMIAAAKWAREKKIPYLGICLGFQIAVIEFCRNVLGLKDAHSAELLETTPDPVVIFMPEISKTHLGGTMRLGLRPTVFRPNSDWSVVRKLYGGAPVIWERHRHRYEINPAYVERIEEKGLYFTGRDERGERMQVAELQGHPYMVGLQAHPELCTRPLNPSPAFLGFIAASCGVLEEQIVRQASYEPPHPKSHLHMENRDVPDVTAVTEQVAQVSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B182</accession>
    <name>A0A2S5B182_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000117">
        <property type="protein sequence ID" value="POY70421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B182"/>
    <dbReference type="STRING" id="741276.A0A2S5B182"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="29"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="8">
        <location>
            <begin position="417"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="485" mass="53997" checksum="82E5F06FC468310A" modified="2018-07-18" version="1">MPTLRNGKSTATESSAANGHTKHASDKEQLVILGSGWAGYAVMQKVDRSRYHVTMISPVEYFVFTPLLSGAAVGTNDFNSVVEPEYHQAYARKVDFKRKTIECSPAIGSEIRKQELNRRIDDDSDDAIKPAVSYPGQKLYTIDYDKLIIAVGCGTATFGIEGAEAHSFMLKTADDAQKIRTRILECFEIASQPTLTAKERRDILHFAVVGGGPTGVEFAGELHDFLTGDLEKAYPSLRPLAQMYAESVAHKTDWRLTLPFYSTIYDVAPGVLQGFDKSLSEFAAEKFKRQGVAIKCESHITRVCEDHLEIEEEGDVPFGMLVWNTGLAANPFIDSIKDLKKDEKTHVLRITNRLNVMTEKDEVYGDVFCLGDCSALEKKAPPTGQTASQQAEWLAKNLNALVHGSAPPKPFKFRNHGNMTYLGDFTAIIDRSSDVEGPEGSLTGKTAWLLWRSAYLYKSLSFRNQVSLVYHWLCTWIAGRRVSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B198</accession>
    <name>A0A2S5B198_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin, alpha subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B198"/>
    <dbReference type="STRING" id="741276.A0A2S5B198"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19756" checksum="BF19C40133EBAAC0" modified="2018-07-18" version="1">MAGAAPPPGSVSLQDLSLDQISQVRSQLEQELKHLTAAFGDLKQAQSKFMACIDSLDSIKPANKGTPAPPLGSTCISRLTSPEAHKTILIPLTSSLYVPGRIQDADNVLVDIGTGYFVEKETKQAKTLYNAKVLALKSNLATLQQQIETKQSNFEACTQMMRVKMAQQQQQQQGAGPGAAGASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1E9</accession>
    <name>A0A2S5B1E9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1E9"/>
    <dbReference type="OrthoDB" id="2528304at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="663" mass="67883" checksum="579F644E8C064AE8" modified="2018-07-18" version="1">MRSLRSSLSAGRSGCVDGSAAAAVARDENKAVATSRSPAPPLVDDASSWTRSTPDKIAQTGKLSDRIAKLGLGTPPNAGGAAVPTSPSPDSVRTGAVTRVSDKISRFQANAEHRPLLPEGGSFAFAPAKPRVSTGSARERYADDKQRVVSLGGGRAPVPIAVVTPRSASTSSSPRIGTPEPAPVGTPPLLSRSSCTASGKDARPEPVPERAASDDDDVSREGGEETPVASPSVSAAGLVGLTDRPDAFSLNSLSAEPRTPGAMSVSSMRVETGSIASEGRDGNPATLDLSQSDALSDSPLSSPIVSGLTIPASTSGSVSSADGIPPSLAPVALDGCGDLAKGLVQKARALSRSGSTVSFSSMTVEAPTEDVANMSLISNEDGPGTPTTKEPASDEASGSAEGNTNEPRAQTPATEAPTDAERLERTREELAQYEGEKSDPPVKSPFAPPSGQQEGQQTDHGEPVEPPLLEEPAEVPREPASSYQQVVEPERKASPIPDVKCSDCGQDVPLLDLADHTCAKGEVAPSSVSPPPVPTYTNDAAAPTSDRPDPDVPGEPMEDDLLDPNATSHATPAAYSGKGPKLDAFVPQTDDLVPEDVLDMYGDEAEEEDAQHATAASEAAAGEPGLPRSGSIDSPLPGKYYTSDDEDHGEPGSATIVRSSSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Y7</accession>
    <name>A0A2S5B1Y7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Y7"/>
    <dbReference type="STRING" id="741276.A0A2S5B1Y7"/>
    <dbReference type="OrthoDB" id="5582162at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="148" mass="15955" checksum="CE5C1BFA3AF991BC" modified="2018-07-18" version="1">MMQRLRPLAASIRSQARVAAVAPFLTAAAAANSHSPRFYSTPAPVTPPETSVNASELSFNPPSSESVPPYFVPRTAGGELPVYSDARNGGSRVYTIVRKTRGDLAALQRDLASYLTDVESHVKPSAGQIVLRGDWVRETKEWLAAKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B208</accession>
    <name>A0A2S5B208_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_6131</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B208"/>
    <dbReference type="STRING" id="741276.A0A2S5B208"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="15">
        <location>
            <begin position="264"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="33"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY70721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="544" mass="60016" checksum="45DA8978E870D996" modified="2018-07-18" version="1">MHLIARQAVRSLRTAAQPIPRPATVNVGHSVRYLRSTGNPTPPPQPAATDADPASAAATAAAQDAPPATPATQTGKTPSAEAVPPLKSADQLAQDPAVTEAPKPNPADPTATGASQVSPPTDALSTRQNSIAEAFLDLHPDVAPRTEEELRGGSQFPGDKTGAKARGAGKSSIEKKRANLARAAGAVTVAGLLWATYDLGKDWADEDEAKKMYARSDDQQAIDEAAQGGWLGWWGRLKLRAADHLDYLNKPAWDPLLPAPLPEPHYRPYTLVIDLEDMLTHDNWDLEHGWRTAKRPGADYFLAYMSQFYEIVLFTTLPSYVVIPIIEKLDPYGAYIPWKLFKEATRYKNGMNIKDLSYLNRPLERTVILDTDPARFQLQPDNGIALQPWMGSKGDATANELVAMIPFLEALAIKRVKDVRPVIKHYEGKHIPTAYMEAEQRTKQEILDKWEQQKKDSSVKGWISSLFSGLTQGTIRDAPPETDVEQMRKAAQKLYLEEQKYWKDNAAIIEQQIEEDKQRQLKEMSSSLVGMMGLAPPRPAPGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B233</accession>
    <name>A0A2S5B233_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B233"/>
    <dbReference type="STRING" id="741276.A0A2S5B233"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="83"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="534" mass="58051" checksum="F7D9E5DF87EC611C" modified="2018-07-18" version="1">MAPSVPVPELARDEKTHGEDQLHEYADRPAARFADGQSLAEYTTTTSEKAGSSRYAESDAGLEHVRASKAAERKLVRKLDVLIMPLAMLLYLSAYLDRGALGNAKLQGLEEDLLEPNPDVKYSIALSCFFITYILFSIPGTLLAKQFNPSLTISCGALVWSLATSAQALCTNAPGLYVCRLFIGLGEAFFGQAIAFYLTLWYLKTELAKRIGFFISAGSVAGAFSGLIAYGVAQIDSKIAAWRILFAVEGLPSLALAVVVFFCLPSRPDKTRYLNESQRTVACTRLNAHSQGNERMGIQWAAVRYALSDWRLLVLCISYSAMNLTLGSVSGFLPTIVKGLGYTSTQAQLYSVPPYATALGCMLLLTTLSDRLQSRGLFVVLVYCIGLVGWCILLAVNPIGVTAGGLRARYFACCCLASAGYSNIPLIMAWVASNAPNESQRAASMGSLNSVGQCLSILAAFLFPKIERPRLIKGASVNIAFQSLGVILALSMTLYYRRENRKRDLAEGGPPPKGMRIENIDTEYDRAKGFRYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2V2</accession>
    <name>A0A2S5B2V2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2V2"/>
    <dbReference type="OrthoDB" id="2524678at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="501" mass="56513" checksum="5E7C8EDAE9CCB9B6" modified="2018-07-18" version="1">MYRFNQIYGYGQDHPQAQMRRMLSPGQDYRARLRRRGALPPHTPMRGAHDHHHLGQNPPRKEVYQGLKLDEEQYGPGHWQHAEIPPTYDAQYHAPTEVLSRQPVLCPFFVPTSEPTHNRAAKRAGLDKKAVDVVSWETIHPHDHGGDFLDALFRETHKRHIQHVLKKDRPDLPQDKVSREVADIHRKYHPHGSESFPQLEPFYNIFRPLANEAQASETFFANVIVGARDAINRLIRDDFVANGMYPGIRVEIESQARVGPDGDASSALDFMLSLVSWPLTVTEDAFRIHLVAVEMKRPGYVLHEDWALEKGMALDSRAHSLATQLFWYTLRDEQRVERHLLSDYVHSVAVAVDYDSVHAAHQGHDEPIVMSAVPITNRPPKGKRAPKQADPYAFPHSLESPFEGGPRPALVYMLYEALRTLGVLNKGVFPHARFYGGDGDGKQERAIEVDPAVRKFMKSVAATRGGRDSPTGGRGGPEPSSDSSDIDRLAKRFNKSTLHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B394</accession>
    <name>A0A2S5B394_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A/B superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B394"/>
    <dbReference type="STRING" id="741276.A0A2S5B394"/>
    <dbReference type="OrthoDB" id="9998495at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="2">
        <location>
            <begin position="40"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="219"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="469" mass="50638" checksum="DC88AF7CBEFFD013" modified="2018-07-18" version="1">MPRIPYKNPAKGTSPVGDAIRERRGARGLTPLDQALLNAPEIAAGWNTLLGAVRNRNSLPDDIRELMILRVAARNSATFEWIHHAHVGVDTGLTAPQLTVIRDLYSPMPTPQSPGVLSPFQAAALRFADASTFNVTVPQSRLDDLKQFLKDDQQLLEVTAVAATYNMVSRLLVTLDVGDMGTVSVPLPETEQTEHDVEVENGVSLHVHVAKRTEDDNAPWLVFVNSLMTNQKMWDGVLPRLSKKYNLLTFDQRGHGKSSVPPTKCTLDVLAKDIATILQKLSIATPIHAIVGVSQGGATALAFAQNHPELFSRLVACDTQATSPAANAKAWDERIALARSEGSMTKLADVTVPRWFPQGSTSELNAGGRREFFIHDMITSTPVEGFAMSAAALQGYDVYPGLAGKLGGKKVLLVAGERDGALPGVLSGLKDKLAADGVDAQFEQIPNAGHLPMVDAAQQWLDVVEKFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3H6</accession>
    <name>A0A2S5B3H6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3H6"/>
    <dbReference type="STRING" id="741276.A0A2S5B3H6"/>
    <dbReference type="OrthoDB" id="3251367at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="766" mass="82140" checksum="B7F002FECFFCD82E" modified="2018-07-18" version="1">MFAAGAAHLSDSVQTTSQSEYAGDYAGVGTLYQQRPVQLASSSFNIREWPQRQSGPSRETSLQGHLHGPKFASHSRPTAIAHEIDTFPAPLTAHNSLASFKAAHAPTASSSQGGCSSDTHRTSSNVDLDFSFEAEMPPYRQPDSLGPVDLTGVPASGVAERDFVEIDMVPSQHDVPEGQLVRSSSGLLVDAKRERASSAMDLRAQFKAAEVAAAHAQLTALSSGADDSDNMSSEEFSRRAEVREGKRPAEGERAISQTAPVPTLARFARPKELFVPTATDGHVVLIPEVSPPRSAPPRFSATFASQQEHARLERSKVAEKRTSRVYPLPLRLLQRDRYADQAHVQLRLGSRHGPTPSESDLDSADPSPLFDSDWEGTARTAPSTPNDTPYLQGCFDPEDLAPPVPHRLDSSGRAMLGEGDVGLGIGLGVMCEGDGDLSEEQDGTIERNQYPMVPLRACRRASLPPPPPQGRHHTIPSVSISPPSCLPEDEETFRPPVGTSSSTLSEDSAADPTVSPTRRISRRLSIALGEPVADNIRDSPLSPASTPTPDLAASPTVRTPQHLLVNPTPTRFLSLRSPSFSFSPAPLRLVKVQLLRAAGYGAGPAPRQGTPSSSSGAHTAVAVQGGTMTRSSSTWRDFVDFATLSPTAHFDEVVPAKLILFAGFFLGPWCWLVGGWYMRPEDGEFRSTRGLRCREPDCGCGRILRGSALRAHPAAVAAKNDRAVRVGEQRFAGLDRWIFWNRFAASASAAVIVALVAVAIWAAITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3J6</accession>
    <name>A0A2S5B3J6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5627</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3J6"/>
    <dbReference type="STRING" id="741276.A0A2S5B3J6"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="12">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="236"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="9">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="9">
        <location>
            <begin position="310"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="9">
        <location>
            <begin position="321"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="346" mass="35423" checksum="857622B9D2BD29C7" modified="2018-07-18" version="1">MAPLALFGDDLDMNGTPTAVGESLATPAAEPPRADILVVASQLAAQDGSYQALVTELSQKGKVEMQMVDRIMEGATSLSAGQYKDVAVLLPANLVTSSLLTLLEPALAPGGSIEVRGEAADSEEILGELTLVGFSGANKTSNAVVAVKPASTSSAPLSLKRPASSLDPSASGSASSSALPATGSAVPLPGRTSRAAKASLWAFTTAAASSSSGVATPTIDESTLLTKEDLERPTLVQRADCDVKRTRRACKDCTCGLREILLDEKEQDDLVEAGFAAQPNTTAGNASTDAVGQKKKPAARKIKSGVTSSCGNCYLGDAFRCGSCPYLGMPAFEPGQKVKIGGMDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3R6</accession>
    <name>A0A2S5B3R6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3R6"/>
    <dbReference type="STRING" id="741276.A0A2S5B3R6"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="151" mass="16136" checksum="882E652D3DC64599" modified="2018-07-18" version="1">MASIALATLQTARQPARQLVGAFVLRTTASTSTSSSRPTSLYTALTSAWAPALPTAALPSLASLIPDTLAGLRELLPPWLLAAPKRRTTHGAKRMRSSNKGLKDKQNIVSCPACGSPKLAHHLCHECHTAFRREIHREARGTGVPAETPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B466</accession>
    <name>A0A2S5B466_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B466"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1012" mass="109423" checksum="0E6F31B620DAA9CD" modified="2018-07-18" version="1">MEGIGGTSGLADPPPSEPVVDGAHVPSIAAAEPLLLRAGMTSLVDPSAPASDNDEADLASGRFEREAAAGEVLINDLALASAATPSDAPADAATLLSGDAGGTLAGNRVAASGGQEYGGPETQAGDDSQLGLITTSQLATRVEELVTSLSPVQLLAWDHFVDAAANMDAEQLRAFAQSILSDADAGKAAAAYAADPANWETTIGTDAAVEAVRGFLAGAPSVQELPIRPDESYQFMQGLGQATTVVEGLVRYPKTLKILLITLHMKGAFKAGLRLHVITTIHQATQHMSDYVAISTLVERVWGYPDAFRMTFLAQADDLTTTHDKPWECLYTSGLYLAGTTTANLTIAGSAIKMSFVKDLASAEKLAKSEERFVATRFDLRNPNSQGFRELQRRHSKDAIMRKKGMYLWNTDPEVVERAFDRHEYELSQRQILQDRLRRAEASSMYADSDVNSSALQCTLMATSADPCQISTSTGDRSEGRFVAPIVDKERRATQVLLGQFEALKPKHPKADKSKRANAAEKKAVLARLEAELTEGQRNTLQLAKTRRRSRPKITGSAGVKSDPVPRARRQDGLRHLARTFGSQVAEGAAAGATSGTDYEGDDEDTPELDAEEEEAVQRDLDAMSAPLSKEARFPASIRDQACKPQSHAAASQSSSPFEPTPNAQSGMRAASSSLDKQPRPVEAFTASSNKSLASIFDMRSFRKTPSKQLPSLACSDKASKVAAPSAVLSARSHKPPAEPMSETAQSDKMEIETDAETDSFASASSADSSADSSASTSSTDLPARKKRRKGVRWTANEEDELLRYVQGFPPPRNIKWAGLQIGEHDAKACADKFRKLPELKKRQATATASSSPWTLEQLEELKKHALSFEASSNIRWVGFSVGPHNTQACVDRWAQMPERKARREGDTRSLEKWTPAQEEELLQHVATAPISKPISWHALQIGPHNSQRCQRRWHTIFSRDATKWSAVETRSLQESTSNGCLDLAEAVRRTGHSARACACLWRKGLDKPDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4H6</accession>
    <name>A0A2S5B4H6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4H6"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="247" mass="26815" checksum="4E9DCD7031593CD6" modified="2018-07-18" version="1">MSTPQPDDASSTPADKARSDSPGPTTSAEQAASRPESTSSSTASPAATPQAEGEQEQEHEEKAKEDDAAVVCDWQAVFSAEANAWYFWNAKTNETTWSNPRQSTSAEAGPSAPTEAEPSDSRAAELPTEGGLPPIDPDLAWLDPAAARRSAGQVTQTARFNARTGRFQADPAMNPDRISDFKRGQRQQEAFYDVQGWENSLAGKGLKRGTEEETDGGRKRPSTKQVQQFKQAKEEKKRRKVSSWLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B543</accession>
    <name>A0A2S5B543_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM-dependent methyltransferase Erg6/SMT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B543"/>
    <dbReference type="STRING" id="741276.A0A2S5B543"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000232">
        <property type="entry name" value="Sterol 24-C-methyltransferase erg6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="365" mass="41042" checksum="0759AD8E7BBCD592" modified="2018-07-18" version="1">MVNAPETTKRGSSSSALIEQRNGDVRNRAGIASYTAHWDKDSSKDTQENTDSRKEHYTDVVNGYYDGATELYEYGWGDSFHFCRYYPGEPFYQGIARHEHYLAAHTGLKAGMRVLDVGCGVGGPAREIANFTDCEIVGVNNNMFQVLRARKYTEKQGLSDKVSFVKGDFMALKEQFGENSFDAVYAIEATCHAPSWEGVYGEIFKVLKPGGTFGVYEWCMTDDFDQSNPRHKEIQHGIELGNGIPEMRPIAKARDALKAVGFQIEHEEDLAQRPDRISWWYSISGDMSKVQSLWDYPLIWRMTKFGRNLTGYGVWALEKARLVPKGTYDVQEALKVAADALVAGAKENLFTPMMLFVARKPEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5D2</accession>
    <name>A0A2S5B5D2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000064">
        <property type="protein sequence ID" value="POY71945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5D2"/>
    <dbReference type="STRING" id="741276.A0A2S5B5D2"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="830"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="621"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="697"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
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        <location>
            <begin position="724"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="743"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="857" mass="89102" checksum="F7FB5435618792E3" modified="2018-07-18" version="1">MYSAPPPPTYQHYQPPPQPIQMPAPVGGPSYGLAPPVPPSAINPSSAAIGQPLQGFKQQGMGVGTTAGDFELFGPTMTAPKPIPNASTRQQQQQQRIPIPSSGSSSEASSMGDGDYPPVPELVADSDAPSPRSFSPPSPKFTVSPVRPGLLPHPNRAAAAGSSSSYRSSTSSSSRGSNNGSYRSERASSVPAPECPRPMRRKTQESRDWPSFYSSASSSSSSSVSSLTGAPTPQLGESKPLLVVDEPASFVTPTAASAASANPFDVSSFALSPAQPFYSAFSPPYTDHPLLPSEQSDLLDRVRRDLLDVDLSSIKGPLRALALSSSGGGVMPDYDRETTPTQQLFSPPRNHLLRSPATTASDATVSPQEAFLDYDQVDSRLHGSSSLFASMAPEINTPALSQSTAQLTLSPPGTAPPPVVSAAPTSPRLSTHASTHHHPRRPHPFSVPQNAVTWAEKRSKSGHRVVGSVLVGGDAADNDGDFAGEDDVEEEEEDENDSSDSPVKEEVVPVTRPGFAAPRPAVASDEVPFKSKSEDTAREDVKPFLVGSTPLPPTTMSFNPLLPLEAVTSSIRGGFPGFAPPPPPVTMSAAPLSSASASAPGSGSASAGQSAFQQELARQRGTASPATSATGTGTATPRRAAAATALTGLHGIAAMYDGSAASASSDAGLDVPARRPQRNRKRSRIAMSEEDDYDDDVATAPAQQPRPGFAAAPPPPPPPAAALVTTTQNSSARTSPEPDPESDASYHSSGSSFGGSRRQTGASAPPNKRRRRAQGSASGATGSGSIVCNHLNSDGSTCGVIFRRPYDLARHKETIHGEGLKGEKVKAKEWKCAECGGTFSRKDALLRHGRIRGHSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5F1</accession>
    <name>A0A2S5B5F1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BMF94_5023</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY72014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B5F1"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="17">
        <location>
            <begin position="1561"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="16">
        <location>
            <begin position="2244"/>
            <end position="2556"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="18">
        <location>
            <begin position="2559"/>
            <end position="2591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1515"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="POY72014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2591" mass="286872" checksum="4475EA6E0C61C6D4" modified="2018-07-18" version="1">MAPEAGPSTQMRPTQALPQATHALLHTLAPVHSTHFPRLARAVHADTTEFSTSQQRQDAEQKMALLKSVLGGWLHGVEADLEAEKDASETKENLTALIETLPGSLSGLRAKPRLLLHSLRDGDASAARLRSPTKSAANMQTESAQDADDEDEDLATFLVPRCLSTCARLQAALLDPVVSARVPEDVIALRRAALAEVETFLIGILDVLADGALRIEWRDKAVKDKARRNGTGKAKQIVHAVLQAVRALLPEVGTDSTDAFPRVLRLFEDSGTADFTPHPTDPKDSPAARSAGISIRSSREALACVVSSLRVLTAVTTTSEYLAQYRGTVLAVVVEAWPTADSFASLPETASPRGREFETDRASLAESREQLVLAWLSMTQAVIGVADAAGRFELQVVAAAILKEVRSRLIRDLPETGDAAPVMLAASFEIEIMLVSGLVKLWALGTAGGARRAWLQDLLQESASYAAEILSEDAAVANGNRRPLAEFVAGLPEAAEWMTAESAIDIRESVGDTLSTLLAKVLSGVPGTDSLSSLARQAIDSATAAAKAMKPEFPRMKRRGNTSQRGTSPRKRMRPDDDDDIILVDAEESSAAEQARQRRARIKQTTTGVLAWCRKSAEQDVGSGAASMLAAGSEESAEQTMLRYISALPSASLELATHLARASGLIACARSDCVDSEPLLDLDTASPSCRVCESAQRPPPRHLQSDPTRSLSKEPLDAVARVFPGYFASLKEDTDRLVILDAFRRLIQHSAHEHPATQSAILQIVKPILEHPTRSLRCAAGEVFLALAIARQEGALSDAVAKDLFAALDAILAQGKPLLSQTVLQLAGKIARRGLLECESLARILRRLGDRNLFIKQLAKQELIQAAKHRGVKPYALVSPHFAVLSSLLVSSPLVLNTALDVLHQSRESLLRVTREHILPDIIFRRDDKLLHEVVKASRADSVAEMLCDPPVAAAVLAHLFVQSETARGPALKYFTASCHGVVLRNLIESVHVPLVYHLALALGDEHPAVAAQARNALVMVERYRLGHSADVKIDIAETLKHVIVGLLSHMNRGLHEANHQRPLRDKQRIIRSLDCITRMVGRAISGFSPQIMATLQTALEIPGLRLVALRAFLSFIQSLKFADIGAFIGPTTAAFVKLWPELHLLEREAAVATINYIVVENGDNLSAYVKDVADLADIPELALADRRLQAVRRTWTFATQLDNLLDRVGSENEVVMLQGLHEMRAFLNSNVAQLHVLASGDTFDPSLGRLVAVLLGAAVREGVENELHRNIAFECIGIVGAVDPDRFELPPIEQPPVVVENFLDGTEAIHFAIRLIVDLLVGAYRSTNDTKHQELLAYALQELLQFCQFTSDVVTGNGHSAAEELNRNRWLSLPKNAMEACAPLLTTRLSLQNSSLDAVSFPIYENTSTYREWVRSFASELLKRVSPECTAGRIFAPFAGLLHLEDTTIAQYLLPHLVLHVLISGKDADRVAIKTEIETILRDQLSRTQDLSENSRLLSAQTVFALMDHLSRWITLAKKLLAEIKAQRKKTKKERQTNERDIYEGLLSVEGILQDVPHILIAQAALTCKAYARSLLNFESHVNAERRKRGPGCDRELQGYYENLHECYAHLDEPDGMEGISTRILDPSTQHQIREHESTGRWTSAQSCWEVSLQQRPDDPENHVGLLRCLRNLGHYGDASPPDSMRTHIAGLFASRGGESDWERILAPFNIEASLFVGDWCGVEDALEVPGVDGPEAAFGRALCAIRSGNQAAIERSFFEARESLGNPIVAAGRESYRRVYESVIHLHILDELQQIQRLQLVGPSEMPALTASLAARLHASAPTFRAREPILNLRRTAFSLASLGDKATRSEVGALWLETSKIARKAGHHQTAYSAILQARECDADFAFFQSAKLFKANDQTYKAIQELDNKISPLLAAHTVIEAQRTQRSSPLAKAALCRVRWMLEAGRLETNEAALLFTEVEKLAPNWENAPYHLGHFWDSQADEKEKKQPRSKGKRHAVEIASYRTQTVKLYLAALTRGTKFIYQTLPRTLTIWLELGERPEVLEGMKKERSNTNDGESHDLTRAFKRCNRYVKESVIVRPIPSYLWLTVLPQVVSRILHGNSEVHDVIETILRHVISTYPHHGFWAMASGAKSTTNRRAKRNMRVFQKAKDDKRHSEVDVLIEEGLRLVDQLLVLCNFAINDKADTLSLKRTFPSLHKLTPTKVIIPLQNSLTVSLPFDASQAATHKPFPEYLPTFQSFDDQILIMSSLQKPRKITVRGSDGRSYGFLCKPKDDLRKDARLMEFNSMIIKLLKKDSDARSRRLNIRTYSVVPLNEECGLIEWVPHVVVLRGVLAKRYASMNVAAWNPELKRIFDTIRDDPKKTAERFETEVLKNFPSIFHEWFLENFPEPSAWHRARLAYSRTAAVISMVGFVLGLGDRHCENILLDGTTGDTVHVDFNCLFDKGRTFEVAERVPFRLTHNIIDGMGVTGVEGVYRKSAEISLRILRANKDSLRSVLETFLHDPLVEWVHSRSKRDSSNPPDQTKARALEALEPISNKLMGLQVTSDPESLGPKEVTIEEQVERLIREARNPHNLGSMYVGWCAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5P2</accession>
    <name>A0A2S5B5P2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5P2"/>
    <dbReference type="STRING" id="741276.A0A2S5B5P2"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="600"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1064"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1136"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1166"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1231" mass="131443" checksum="33808D3210E31A8C" modified="2018-07-18" version="1">MALDSAPADDDPTLLAADYTLPNQRRIAQLNAILVRNLSIRDTRPSHPSFQPTRTADRHDDDSTRDRRLDDGAAGALNGIRPLSTTRTTTTLAQGQITSGDEARNVTARPSRPTGAFRRSASAGTLLERTSGSSRSSRRVLNATVGEADTIAEEAPAPSEGTPSLAAPSQPDARHPAVKPAREPALSRPRTRSQAEADRRRTALHDRLVDCFVSLHLLPPAAAATTFPSSSSEPTRTAPSAGEVSFPDRRHAHGRSRSGSVRSVFARPSGSGQGGSAPGPAPGLSRSGSANSVRKTDSATVGASAFATSPRKTMRRRTTVSADSFAPLPSFPSHTAKSPSSTLFPASPVAAALAPPPAPVRPFFVSDLSQAATHATFFLDPEQITVPSWSSASSGMPSDPTAGLPAFPEQVRDWPGWTESRIQATVWARPTTLDEEGGSRSTRASDDGGKGKAKATGDEDDWRVVAEWEVDLAGLTSLGRDPTEFPTLPPNTLVFAMSSSGVVPQFPSDPSTSSAAATDEIEYFTAPIPLLERAHRRRLRAERRARTTAASTRFDSSSSGSSLPLLQQRSWSEDELSDYLEECCDDSECSDCGADGEFGDAVPFRGSDEEVGGGAGYTSDPGLGADGAVVRRPRSDTIRSRRSGRSGARRGTLLTSHDPVQSGSTTALGTTRSSSQRSRPPPSLGAMATTTNNRIEPAEHVRRRNRRAAQEVLEKSRRETRMVRAAGWEGIRKLCEARWELEGIKREVADRRETVAREMGDEEEGWSAQDRLRAELRDRLEDLEGVKEAVDSELSEEQYELDIRRARLRQRRDRLDRAQILDLEHGEALNEVQRELHAAAETHAELALSAQTRRTQLITLLSHIFPIEPVFSAPKGISPDLLFSILGIPLPNSTFPSSYSDDAVSSALGYAAQVTQLIAAYLSVPLCYPITSCGSRSTVRDEISMMKGPRAFPLFGKGVDQYRFDYGVFLLNKNIEQLMYAQGLTVLDLRNTLPNLKTLILSLSYDPSHDDFLASTLLPTGPFAADEEDDRQPPDHSVPEGDAFPTEHSGPEAAHPYDEEAERATVTTTRSSRSTSNASTIRPSKLLVSTHGQREAGVPATEASAPLPSEVAPPDLDPLSISAAGDSSPKGDVTPRKSRRNGRRRSSSSASEKVTLVKTVHKAHGRSPSGGSPASSGSGHASGGGGGGGGGYGAKLREGLWSVVAGGTGRRESSASATENGPQGSGPVGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5R5</accession>
    <name>A0A2S5B5R5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5R5"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="291"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="486" mass="51005" checksum="C4A5749301DAD20C" modified="2018-07-18" version="1">MVAQIQLAAPSSSAPQSTRTPSFSSTKNSEDLSATNETPSFQYPPTASRTSALSAETEADQTGSASAADNKEAFDSYPDSGWNAWIQVAASFALFATTVGGVYSWGVFQDALVARGLAPSSTLAFIGSLQATVQAVFAIPIARLVRAYGPRRVAVAGAIFTGLGPILAGWCTENFAALLITEGLLFGLGEALCFFSIATLPSQYFLRRRNQATGLVYAGSGIGGAVFAVCTDQLLKRVSLPWTFRIIGVVMLAINLPAALTLKARAAKQPFRSETKTQTKTFDASLFKDARFNLLLVGTAIALFPLFVPPFFLPQYGTSVGLSTTTSALLLAGWNLSSSAGRIGFGFGADTILGSLNSLSICLLLVGLSTLLIWPFATSIGPLVLFAIINGFCAGGMFSLIPGTLSSIFGTRRLSVVFSMLLTSWTPGYFLGAPAAGYLLQAYGGPDQGAGAYRPAIFYAGSLSLGSAGCIIAVRLLQSKQLWKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5X0</accession>
    <name>A0A2S5B5X0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5X0"/>
    <dbReference type="OrthoDB" id="2537435at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="607"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="762" mass="79393" checksum="51A2B712DF470340" modified="2018-07-18" version="1">MSSAAGRKRTAPNDGTDPDHAGPPPASRRRLTFDSPSPEPLASHQLEPSDLVTGAKHTHQLVNALSSRIEQAEHEARDLSLSVAEAKQIRDTLSASVAQFYDTPATKGDILSLLLAIDKIGGSTRGPSVANSEQDAVHPSPFQLLPFDIVRLILLHVRDLYLDELPSDSALTLGGVGGWRRLVRRTAGLSSNLREVCKALLASEVVVTDVKALEKLSKKIANGKVRAKTVSRVTMAPRHYGLNGPDRDLGFMIPDLLASMSNLTYLNITVDRTTYSLSDAVLRGRPFDFDAFTGGVDVADIIVHHLQSLRELMFGVPTTLATVAKFTSTIPTLRELSVVGEVERVDGATVPFSLCSPLLRRLWLPTTILSPGDLGDLLGVDVTKEESIAGLASSSDPQRRLDALAFCFDVDDLFSTTGTPITDTEIAHRFTYLENVFSHIGRDLTELHVSTPGADHPDAIRMRLFHTAALGGGGANRLRGPGQGGAAGGAPRPPPGAGAPGGANPLAIGPPITLTFAVLGNPPHGAPVAPPAGNAVPQPGQRAGAPPLAGGQAGQGMGNGPTGQAVNGAAAAGNPGLGRGLRNLFGLGGGNNAGAPNRPHVNAGAPNIGPAQPAAAAGPAAAPRAPPVGGGAAGGGAGLLGNGFNLLFGGQPLPPAVPFFGDLVAHCPNLERLELFGRRYDAALVDTLRHHPLRRLSVSVPNDTARAEFVTTLIAALDQGAWPDLRRLELCAGGGDWAPAERRQVMQAAAKRAKLVYRSTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5X6</accession>
    <name>A0A2S5B5X6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000056">
        <property type="protein sequence ID" value="POY72193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5X6"/>
    <dbReference type="STRING" id="741276.A0A2S5B5X6"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="9639" checksum="DAACA6F8148600D9" modified="2018-07-18" version="1">MQGIKTVAAISLAVNYPTLASVTYSLVNSYKNLLAVALETEYSFPEAEALKDRLANPDAYAAAAPAADAGAAAGGAAAAEEGPAEAEEESDDDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6C7</accession>
    <name>A0A2S5B6C7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6C7"/>
    <dbReference type="OrthoDB" id="3359404at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="159" mass="16916" checksum="74F9EFF3C9907BC1" modified="2018-07-18" version="1">MAGRTQIMTRLGPIATGLRPRPTPVSLAAWTRPYSVTTPSRAPAASPVEVPSHPATSPPPSGGSGRQPPKPRSATSEFYRALVPSMLHCLALGSIVYYALELGYVWLAREKEGEELRLRVAQLESELAVARTSPLGDAGTAGGGALAGSGEKRSWWKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6F7</accession>
    <name>A0A2S5B6F7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6F7"/>
    <dbReference type="OrthoDB" id="2537633at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="274" mass="28663" checksum="528851066847B1FA" modified="2018-07-18" version="1">MAHPTVGGKGLPPVVSAPVYLPSSPATSTAGYGGYLAASSSKLPSYYATTAGPPPDLTARLQLKAKYARIQARYNRAIEARRDLTIELEEKEATQQRLQDEVDLILDQIHDSDYAHLIPKRDSLFSDDEGDDEGEENGDEANGAGSGDDSGLGANGTTEGATARTAVRKGKRKADDRDLDDLEDQRRRQLEVHYGIDGTRQNVSRIPTPPPQNARPPAAAPTDAPVSQQPASAPAVPGSIPPPQSTAAQTPAPAPTRIKLKFGGGGGSSAAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6G8</accession>
    <name>A0A2S5B6G8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6G8"/>
    <dbReference type="OrthoDB" id="2501045at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015572042" description="Proteophosphoglycan ppg4" evidence="2">
        <location>
            <begin position="21"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="66811" checksum="48FB101A9CDD57CD" modified="2018-07-18" version="1">MRSYALTSLALSSLALFAAASPEPCSDHPGVVHKPGEYTVPEVTKLVDPAPAQQQAPSSSDKKHSSQKSSTGSSQSKTWKAQQAVDASSGSSSSSSSSSSSGSTKKVKVVPSSDSSNPSSSTAHSWAKNANKVKAKPAPKIKDASAASVAAGAAAAVGSFANSSLIPPEVAGALSGAISSVIDKQLGKTSEAVVTHTKTTASVSTMLANNATATGASVHANATVSANGTVAATPAPTPAPIYITVTQNVTELQVSTSTIITTSDAVAASLNIKQALDEAFAAANLSQSGLNSTTTAALEKCLTEVLAAGGMPNGYSCLTATGSDSAGLQTTLNTILEQFVGILPNTILSSVFDAVTPLLGNLLPASEQALVNQIQASIQSVIASLSGNSVTALEQVSQCYTEAIQQAGNTSSLACFTKTNGAYTTLQTATNSVLQQFVGVLPAALTTSVENILAFNVQNATTPSAQLGAQVGAQISNAINSVASSLSDNTVTAAEILQSCAAELISSGNATAAQECITQSAAPVVTQTTILSIAQQYDGYLPSSFFTDLVDYSAVFLNTTANAHNLTQAEVNSSLESFFNNQTSYGAAYVSCISQVEQCVTNAVTKSGTIDAVCPGPVKGCDLAKADAQRLTRRIRRHSGSRHLGFGGRIRDVQLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6H4</accession>
    <name>A0A2S5B6H4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6H4"/>
    <dbReference type="STRING" id="741276.A0A2S5B6H4"/>
    <dbReference type="OrthoDB" id="2527427at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="793" mass="85858" checksum="4706E0A43EA99CCD" modified="2018-07-18" version="1">MCAARPFPFHTGPSVAAAFLPGEPFNTSPTSYSSLSTADRTGVYQHASYDQSVLHHYTPANARQLYPSVRMSSFSSSTGSPISPAQSASPFIPDRPLHPSVAPMIQPPSVGFVNHQQLRSSTSGWWAADDLRGRQAWFASSVRRPPPLVSPTHATSSSFYAVAHTRPFRTQAAVAPPISSPAISQASSALASRQSATRRRKMVVRLPLSGKADHRVPLSPTTQATVAAKMSEDGAHLVEPASRRPHFEEGTRDGLPDTLDVYLPGQIAWQDLREEFAVRLRTEPSLSMEYGQKPDAGRPKQLHSRSRSLFTPPQLLPPRFRTAGAHDEGWRGHRLAKSLTTTTDFVNEAVSGNRADLLTWPPLSIGQPRLESVFAPDNLAGRISSPVPPAYLESDKSQDGDAESTDYAGRCHTASPRFPGSAAFESDGDIPEQGVVVFDGGARSASLNPGALTFQPVASVPMMRTNSPLLAKGTRRPLPPLPIPQTKLPAESSHRSIGFASPVPVLVELKHPQPRRPLPTSPLEASESDADAAPANSLRTGLQAPLDDAERSSTSFEDPLPEQYAPARMYSQQRSIPKDRFAALEPSRPRDAVDGVGQLRPSASSPARMGDPRALQHELARQRAPSGETELAFEAGLSELPTRDVDAETVVSTIADDLPLRILETLIDERFGRLGSELAAEVAKKHAALLQAVEVELSKCIRQAMQPVLEKANSSLSSLDRLVNRLAERKVVAGTTLEQPPSDSEQQDRLRESELTLVEEDSQNVLPHTEIASDARAITEAPMLDKHGWYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6L0</accession>
    <name>A0A2S5B6L0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6L0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6L0"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="681"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="707" mass="77020" checksum="47EC95D8FC01C2D1" modified="2018-07-18" version="1">MAERKDTLDFPRRFRCSRQRPRAKPAADRADLGPTFSPGAVLQLVSNARATYGLRHQDYARYKSHCVAKVHHLRKAAGLSQKAGKSRKYERKELTADKVTSAKSLQVLLFDAERDWAQAQSLKSQHAGEANAKAKHHYAKRFTKAAGRAADLLAVAQAESVSNKLSASQKTQIHTYALVMSGTSAFERSRYEDGLNSLGVAHGLLGKLATTAGSATEEALANEMLDDVEPMLRFCAYRLGKDTSAGIASIAEQVANEETGRLVPDWESLRTRLEEQGQQSKKASVEIRWQGQAIPIRNAELVNAAAKVQDALAGLRADQQSSEKVSAVAQGKKPASNKKDILGARRMGMFDKALLVLSEAEATAAQLVEDNKIAMSKGNSARFEASSKTLATFHAYVQYHLLAVRAKRDLLLVASTQAKLAARERKILHAEEAYVAQTERRDPAVAEGKIKRLRAKVYPGLIKVFDTILLSFEGMRDMEAVEQDDDLATLVEARISYVGALRSQYLSRGYALAGEFPSSLALNAQAKLKARQARFNADATAGSADVQDSVEDSAADHDYVADRLPLDSPSLDSLDAELEADYQKVSQEWFAATGGKVEGRQDDLDLSKLSLSADVSRTSKTTIPKVPFFDVAYNYVTAFDMDAIAEKAGLRIPTQAAAAEVPTAATITDEAQPVKQEVVEEQSMNGEQEAQPTPTKRGWGFGLFGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6T2</accession>
    <name>A0A2S5B6T2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GS catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6T2"/>
    <dbReference type="STRING" id="741276.A0A2S5B6T2"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="7">
        <location>
            <begin position="123"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="477" mass="53772" checksum="7D8D129BC8C28ED5" modified="2018-07-18" version="1">MTTPDQPAITLASLEKLLENDDRVQVAGIDVDGILRGKIMLKSKFMSAAKDGFGYCSVVFGWDMHDRTYSKELGISNLKNGYKDILAKVDLSSYRRLPGAPALPFFLVTFYDPETQKGLYACPRATLQKVVDDLDKEGFEAFAGAEYEYFQFRETPKSIYEKDFHRLTPLSEGMHGYSLLRPELHKEYFHALYDNCREFGIPIEGHHTETGPGVFESALAYQRVSRMADNAILFKHMAKTTGLEHGVLPTFMAKPYADQPGCSGHVHISLRDKEGRNVFAVSESEVEKGRKDAKYEDTARISQIGEWFLAGILEGLPDIMPCLVPTVNGYKRLVESYWAPTTVSYAYESRLASVRVISPPMGDTKSTRLEVRVPGADMNPYFTFSALLALGLRGIRNRIPLPGPPIRPPAPGSKLSYERLPNSLDKAVERFLRPESLARQVLGDEFVDHYGATRQNEWEQYAQAVTDWELRRYLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6W7</accession>
    <name>A0A2S5B6W7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6W7"/>
    <dbReference type="STRING" id="741276.A0A2S5B6W7"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="379"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="606" mass="67489" checksum="0C5F14898E015050" modified="2018-07-18" version="1">MATRSGSSASDTSEASRPRSASPATSLDSAAPKFTERLPVTILSGFLGAGKTTLLEHVLTSRNHGLRCAGYIALTVKSSRSSFITTFSNLRALSMSSINVRQRRGGPPESARLIGLDFQIDAALVSQHKTIQKEETIVQMENGCICCTLRGDLLEEIANIAAKGGIDYLLIESCDAKTAGISEPQQVAETFAAEFSDMHLQAAADLREENKILMSDESGKLAKDRQAQILKNARLADILGAGGLPKIARLDTCATVVDALSFFDNFATTDFISDRQDPSTVDEQDERNISDLMTDQLEFADVVIINKCDLVSKEQLSRIRALIKSLNPDADVVESVRSRVDVSRVLDTKRFSFEKSMLSAGWLKSLQEDVKPETEEYGIGSFVYRARRPFHPRRLWDLVRLRLVVIQDSYEEDEAMDVEGEDTATDSETDATWSDAESGDEDEAQPQLDLAARLATRKADPVFRHLHRSKGFLWLATRPMLSGEWSQAGVMLTVGGAQRWWAETPVSEWPPHADVRKKIRSDFHGRWGDRRQELVFIGEHLELLRKSLTSDLDACLLDDSEWLQWGKVMKSKRTMAKKIEKLEALFEDGWEDWLDEGDAAHVGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B774</accession>
    <name>A0A2S5B774_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin Pom152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B774"/>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="3">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="5">
        <location>
            <begin position="167"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="594"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="789"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="941"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="6">
        <location>
            <begin position="1140"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="1224"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1321" mass="144802" checksum="4C73CB2FF1009ED9" modified="2018-07-18" version="1">MSAPPPQSEQPPLKPRISEEAIDAPTQRSYLAALFVLAQAYKLSEALYPAVGAGASSSEADSVNWRLWKWIAVDLLFVGFVAFLRVPRLEWGWKARWTIRLGLCGLDYVLFGRWTLAASMFVPAAVRSFFTRTLTTDEHSVRLSSIAKQEREHLGQAFTVRVLAVSTVMLNPLSAVFCRHASHSRKSDPTLIPLVFNNTIPSKVVYTVTSFDDPPRSHTLTVPASQLVRRAHPSRHLTDSSQVSAQDDELALASEWSLVPASKPSSQTLRHTLPEDRETYDKNDPFRLSPSESLYYLPVTAIGSIRLESIEDADGHPIRIRRKRTAVTGQAAHDATNGTVVRAFEETRILRCPTAGFSLDAGVLGYAGAVEEHRCLAPNQGVPETWPLGLVVSGTEPLSVKWYSREGDKDRGVRREQELAGIVGASGASDSVIPIPTNASLAKPGRTTFYIETVSDSAGNVVSYAGDLKNPLAEGTIASRAVVVHRPPEVAFVGECARGEEVHLLRQKTKNQSRKLQMKLSGIDEELHDTRHGGRCARFEVDVKYTPEDSTARGWVKRLEATGPRLDFEVDQPGTYEIVDIKSEHCPGAVLVPNSPVPTLQTTFTPVHDVCNAENGMIASLHLTGAPPFAVHYTVTRLSGPGAPRTMHYTRRVSHSRDEFRFDTAPGDWEYRFTSVTDAFYNKLPLDGGASLVRRQSIPVVGNAKWRDAAHGKTVHSCEGETVQVEIDLEGVAPWEVEYAVVGQPSKKISGITRSPYAFDIDIPTAIAKQGGQFALSLDDLVIEVRRTKPTARFHGTEGSRSVLIRDGETARIPLRLSGERPWTIEYLPPASNGRTAEAVRFTAQQPNAELGIDRALAGTYKLLSVRDKYCPGDVSETEWVVETLPRPSARLDAQAGRLVRNGSYVRPGVCMNAADSVAVLFEGKWTSLAQPRFHSTYSRKAPFKAAYTLQKGSHHGETRQHTLQAIQSRADLTLFTAEAGHHTYTLSSVADSLYTDLSAKGLSAPEDGKPGLVRVEQDVYALPSAYFAHGAKRGFCVNDALASRGSDDLILHLDGAAPFEIEIEVREDGQRHSKRYTVPSVQSHKWPVTLPYGLKQASAHSIAIRRIKDAHGCETIVDASAPASQSQRTVIPIPVAEIATIQPVSAQTDHCVGDFLDFVVQGAPPFTVKYEFEGKEHVVPLTSAKFQRLATKPGTFRIVSVGHGEDQCRSNNVDLVKHIHPLPSAKVDFEDSSSIDIREGEQAEIVLRFDGTPPFSFTYTRRAANGRSQDGPVLESHTVTGHTSHEYSIFTSQEGTWAVSFIADAYCSYPSPRQSAVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7F8</accession>
    <name>A0A2S5B7F8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7F8"/>
    <dbReference type="STRING" id="741276.A0A2S5B7F8"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="546" mass="59253" checksum="A73287E9D8353276" modified="2018-07-18" version="1">MQGLPANAQYTVDEYGRPFIVIRDQGKKTRMHGIEALKSHIRAARTVSNIVKTSLGPRGLDKIMISPDGDITVTNDGATIMGQMQVEHEIAKLLVELSKSQDDEIGDGTTGVVVLAGALLESATALLDRGIHPIKIADGFDRACTVAVAELDRIGDVLEYTPEDTSELLKVAQTSMGSKIVSKAHSLFAQIAIDAVLSVADLERRDVPFDLIKVTGKVGGSLEDTTLIKGVLLDKDMSHPQMPRSVQDAKLAILTCPFEPPRPKTKHKLDITSVDEYKKLQQYEMEKFQSMIKQVKDTGANLVICQWGFDDEANHLLMQNDLPAVRWVGGPEIELIAIATNGRIVPRFEDLTAAKLGKAGTVREISFGTTRDKMLVIEDCANSKAVTVFVRGSNKMIIDEAKRALHDALCVVRNLVRDNRVVYGGGAAEIACSIAVAATADRVASIEQYAMRAFATALDAIPLALAENSGLAPIETLAEVKSRQVTEGNSRLGVDCAGRGENDMKKQFVVDPLISKKQQLLLACQLVRQILKIDDVIQSGGADDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7I3</accession>
    <name>A0A2S5B7I3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7I3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="303" mass="34427" checksum="C692319D99E244FF" modified="2018-07-18" version="1">MSRPASTRPHEPASASSPDKPSPLLRLPDELLHAILDDLSLGDVKMCLDACRRLRAVAARRVFTAIRITDEADLLALATHFKHGCYVQSLKIDLEETGKVSEEKREASRYHPFEFHPDEWLPYRYREEDHFIEEISSRASDSDSDEEPEPVEAEVVDLGSFTWTEPVFDVDQDFASSDTQSDDESHAFAAVVQQILRSMPSLAYLSLRSLDWSEYAEFLSDRATPHLKNLVSLELGFPEWYRSTLAGLKPVQWWPLIAGLPNLKRLAFDDCFEICRARDAEEQITAFPSVEEVDIICNSRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7I5</accession>
    <name>A0A2S5B7I5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7I5"/>
    <dbReference type="OrthoDB" id="2524204at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="573" mass="63993" checksum="1DDC7F447FE0A547" modified="2018-07-18" version="1">MNHAASTRPHRPASASSPDKPSPLLRLPDELLHAILDDLNPGDVKMCLDACRRLRAVAARRVFTAIRITDEADLLALATHFKHGCYVQSLTIDLEMSIDATESPRRRCPEYGGWIYEPDDWIPHTCSDGDSADEKGSQISEIDFEDNAQPVASEEIDLGGVAWTEQIFEVKADSSRSSLDSDEEGCDSFAATAQAVLRQMPNLAYLCLSHLDWSEYAAFLSEQTAPYLQGLVELELDTPQWFCSTLTSLDAVEWWPVIGGLPNLVALTFDDCFEICCARDSDVTTIELPNIKELVIKLNSNNVLEPYRSAFSLRVPNLEQLALRDASGLAPSGYHAILREVPATLKDLDLYSRPGLDSASADLDWTRFVNLRTLILGRSTFQPEGLLQRLLQLQQLTLLVFDIGAPIRDDVLAELLRQHRGLPHLERVQLDHVCCESGSLDEEHLSSEPRPYERFDTDTERHMWPGWLAPDWPEGCSEAGVADAIALAEHAGVELDGTALDTIGFQEVYDDEARLCMQKHAQWAGDLREAITEYGFDAALDFLKDEDQQWYRTLLKAINPGGSRHHTPTYYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7K7</accession>
    <name>A0A2S5B7K7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B7K7"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="173"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="315"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="1475"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="834"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="881"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1514" mass="155144" checksum="6C91EE7EE278E9AD" modified="2018-07-18" version="1">MATEPLPPQLSGYNPTKPERDAFNYLFERADQDQLGVLTGDRAVPFFSHSALPPLILGEIWQLADPENIGFLSQDRFGVACRLIAHAQARAKTGPPRVEPDDVKKQAPQPPTFRGHALPDHLAQPLASVATPTSPTSRQQGGAAAAPASPAAAATPQARQPATTNLNQISPSDKANYARLFSAAGPVGIGPAALLDGDKAREIWVKSELPFDVLGQIWSLADTHARGQLDLTDFTIGMHLLHLVLDGKLPRNVEGLPKVLDPALYKAAMTTLPPPPPASSAAATAPISQAQLRPQQTGPAGAAGGQSGWAISPAEKQESDQWFDQLDSARKGQLEGEQAVGFFGQSGLGVEVLAKIWDLADLRNEGHLNKDTFAVAMHLVKRAVADPSTPLPDSLPQDLVPPSIRGGSSGTPFGQQQQQQAPVAPQRDLLDLDDDDAGPAASVSSPQQQQAGGFSLSPQTTGTMAPLSPQMTGPRSPLGQPAYMRSLSPQLTGASASGGSARQGSTPTMQGASAMYPQLTGASTTANAAMTPRSVTPQVQTPQQTGSGGFESNFAPAAAGAAVGAVAAVGGAAALASARQTSSTFFDDNDDDDLATNARSLQSKASNLRTEADSVEQQSKSTGQSRSELEKQVQAANEEIAALQERVSRARSTYEAEREKVEELRTRTKEQQDVLARAKHELIRAESDLSALRMEKTEIEGELLRDKEDVRELKRKVALVEDEKRILAAEVDKLKKEARQNKGLGAIARKQLTSVEADRTKLESEVEQLKSGAGADREEEGGSSFGGVGAMAAGALAGVGAATAAVLGTQHTGASAQDGPATSPMSPSSEIEGARAAALAATAPAAQAATVALPQTPGAAVAGAAPARTGTNPFERFLARAPPASSPSATSPTSSTVGASTNPFARSPLASPPAPAQSETLVATTATAAERDVEPITAGEEHKTSSEPTSLPLAAAAAIGTGAIAAVSAVGAGIYEAVTGHHDEQKDAKEPAAVAANEKDLAAAPSAAEEPDPFGVPAAASTEPTAGEFDSGFGDDFSNAPIAAAVPSEQEHDVPAPVEGQLGDIEPQSGFTDAVRDLNEDGTGPDAVQGTLGEVENDAGFDEAFKEIEEHEHGAGAAGGVDKGKGRELAHSVDSGDDDEDDGPEEAFGSSPRYAGNEHDDDPLASTAASTDFGTASVGDLSAVSGASDAPSVAAEVAPSAEIAHKDDEAHDVAEPTKEQDPTNNSSESGESFVHVPPAAAVGTDVLPSLAVTPTPTSTRRAAPPPPVRAAAVDNGFADASASPVTQADETPREATALPTQAPEDDFESAFADMSVSSPAASSAMFAAAPAAAIAPDFDSFENDFDFQPSFDSSEAAVAARNAHMAAQVQAEVGGTDFDDAAFADFDSSFPSSSSAAAPLTASAPAASASGAADQAFDAAFDDSFNETGPPVLGAPVGIVPFSQVPATDAAAVHPAPAAQTVSPPPAAPRLESFAGEEEGVRVIRQMGFSREQALEALDKYDGDVNRAVNSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7P4</accession>
    <name>A0A2S5B7P4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7P4"/>
    <dbReference type="STRING" id="741276.A0A2S5B7P4"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015453763" evidence="2">
        <location>
            <begin position="21"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="381" mass="40296" checksum="753C1242C199BD46" modified="2018-07-18" version="1">MWSPSLCAAVVVGLPLLAYAAPIQSTGLLSDATIKQVKERLAQSASDTWTAGTQMEALLELDYPTLSVFAAASYPPPSTADAPSAVTAIVRQWASQRGSSDQLAYVAGGAAADPAALGVGWLVAAAFADSSTESTYVAQAKQQVSYLLDSVPTTPDGAISHRPSGEPVQLWADFISMVPPFLAYYGVATSDRSSLETAYQQIKLYRSHLRSSSGAWKHIVLGSGTDAGLWNTGNGWAAHGSLRVLATLKNSQWGSTFDVEIADLTAWVQEILRAAFQKIKSDGLLPNYYDNAHGSYFSDASGSALLAASAYRLATLTGDTSFISNADTVRSAVFGHVDSSSGWVSPVVDPLSFQSEASQSPEAEAFILMLQAAYRDYLATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7R6</accession>
    <name>A0A2S5B7R6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7R6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7R6"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="262" mass="27536" checksum="EC33B67698568431" modified="2018-07-18" version="1">MARSSLSTHDTASLRKGNHLSHGQGAENGYAAAQDGGGAEFGNFRSVTPGGHTLDTSQPAFPVYHRRFANPAPLGLVAFALPSFVLSLINIGARGVTVPNVVVGPAIFYAGVGQTLASMWEFASGNTLAATSFATYGAFWFAYAFIVSPWSGIEAAYASPLEFANGVAFFLWGFFIVTFIFLIASLRSSITLACIFLSVDAVFLCLGIAELGTVGNPHNFQIAGGAFGLVASALAWYVALSNLLTPDTSFFTLPVGDLTKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8B2</accession>
    <name>A0A2S5B8B2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8B2"/>
    <dbReference type="STRING" id="741276.A0A2S5B8B2"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="57"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="428" mass="47454" checksum="5C2CA67701141F63" modified="2018-07-18" version="1">MSPPTLSKRGTAQMTATAASPLYAAMFRTVENLWSVDNPDGIVNAGLAENSLMHDWLVKFWQQEGALAIDHTDLTYATSILGSKRIFKSLARFFSSYFDPLVPVEPTHIATSNGLSPMIEHIAAAISDPEDAWLIPAPYYNGFARDLNTTSQVRIASIDIPVAQYGTVAEVKLLDAGMERRERDGVAQKIRAVLITNPHNPLGFCYSKENLFLIADEIYATSVYDSPDLPNATPFTSILSLDVQKDAGCDPARIMSLYGMSKDFGANGFRAGALVCQHNDALMRALRSTAMMRRMGSPTDILWSALLDSPELPSYLAENRRALSEAYTYLTTWLKRHQLKYTPANAGHFVLVDFRDHVEKLAQEQGQADGGRFKHEIALLNRFVENGVCLDPGFSFGFPEPGFFRITFCIRRQELDIALDRVAQVCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8C0</accession>
    <name>A0A2S5B8C0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY73007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8C0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="404" mass="44771" checksum="F74F3D801D448217" modified="2018-07-18" version="1">MSTPPPPPKPVERRTLHPGNAPARVSDSVYECSRRVTLCGPTGQLQVMAAIVNFMQTKKAWTWSGAGGNQHRVVNANLFHHFSGLPALAVLKSAGAADYGADTEHPARPSSDIREAFWYLLTFETEEIPVLMTILDVPEAFGRVLMDDLIKAVSDWRGENRHSEHIICLPRVTPESPSEARNVYWHDPWVSHHVHIRALPTSATAQRLLQETEPFDCAVKIPHLGRRVLGLREDASEADVSLGRLETYGIPKLLRFTVDSLANHVASAAIHLDQALRGEGSAAGPGVSLEVLRIVLVRDLIKTFSHLPDANNYTLQNLFLSIRWMLKDKEQRQLLVERLSHAMSDAEMRGRLAGALAAKCCSGQAPALTLPGVKTEAVQTAIIRECFEAFDWFKEQLPAFLFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8D8</accession>
    <name>A0A2S5B8D8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Eukaryotic membrane protein family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8D8"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="78498" checksum="54FE131A536C32F4" modified="2018-07-18" version="1">MTAPSPPLSRSLPDLAAAFDDLDGLDDLPDRPPSPLPRVELGKTSTGPQHTTGPWDGEGRDHSYWGQAHEHDGVKRRDEELYGREHLVETGEQWRDVTAAVAEQARIDRSPSIGSIHSAPELAGPPSPRELSSERPAQLEESASRAVESSPPTSPTFSEPRTKRKRSARSPSTLWDYLQEEVFAVEVDGEEGSKSERVTNFLAVPRELEKIIVFGSFVCLDSFLYTFTILPLRAVVAFRHLVSNFAYNQVRARSAGLPRRRLRLSHKCDLTKAAILAGTLTILHHITDASKMYHGVRGQDTVKLYVLFNVLEIADRLCCSFGQDLQDSLFSRHTFARRNDGSHPHVRPLVLFGLNLAYVVAHTLVLFYQLVTLNVAINSYSNAILTLLMSNQFVEIKGSVFKKFEKENLFQLTCADIVERFQLGIMLFVIALRNLIFEISSAATSSSPSFSMPAVSLWLQAVPTLSLLRAIFSPAVVVLLSECLVDWLKHAFITKFNHLRPGVYGRFIDVLCKDLVASGSSDREDQRFVDQSPFVARRLGFAALPLGCLVVRIISQAFEMLVDESTDEGMSPLAAASLPGGVVGLCSRFPTSLSEIDWSGHVAGWALYAALAFFSWTCLVALKLLIGVNLRAFASERWATMNDRISEEQFNSRQRKKIGVTVREEESDRQTRAMLADDAFVDSRQKKVDLSNLTRFDMVKSRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8F2</accession>
    <name>A0A2S5B8F2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_3891</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8F2"/>
    <dbReference type="STRING" id="741276.A0A2S5B8F2"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="321"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY73053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="403" mass="42984" checksum="0C8C9ACCCFD564C5" modified="2018-07-18" version="1">MDDSTATFSPLPRSSLGGGGLGVTGGGFRGPGLVGRPSVGGLLQDEDMSLALAGDDPLDDVDDDDDEADADPFQRVPSAAGRRRHEPPSNAAEDQDDEPTLRLDSASTGTATSAPTRQAKSSADLFFGGSMAASASKPGVPPLGAAAAAGPSSSRRPASPSAHNAAHVPLPEASRPPGGSTGPHATGYEPDEDDVTDSALEARGYAPEELTRIRSLRDERDGLRTMNGVLEDVLGALRQTEGKMEASLFPDLASHAGPLELTCYACCFVTSQNFQATIETSHQLLDLYTRIASQAEHTKNLLLDGEWQGVERDYQILAEREQAAREAEEAAQREAEERAAREEAERVRKAQEEHARQRFLGHPPRLVSSTRASSRFLTPASNDLTFDSFRFADQFGDPYTGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8V7</accession>
    <name>A0A2S5B8V7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-aminolevulinate synthase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_3539</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8V7"/>
    <dbReference type="STRING" id="741276.A0A2S5B8V7"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="16">
        <location>
            <begin position="223"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY73206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="663" mass="70136" checksum="FE8BD8BE55F004FD" modified="2018-07-18" version="1">MLAVDPVLGLKRFGQVCPFLARSSVGALRTFSTQSIRGTAANRLSELATTRCPLMSVALAQRGFRSVAAAQVGSATNHNATTSNSFIQSRPVHQRRSYASITEIEDKAARKAKAVPAKSAQPSFVNPASISSSASSGADAASDAATSTEVHSEGRPTCALGFAKHRVTSYRPGQFDYDAFYAAELEKKHQDKSYRYFNNVNRLAAKFPVAHTADKADEVTVHCSNDYLGMGRHPVTLGAIHETLDTYGAGAGGTRNIAGNGAKHLALEAELAGLHQKEAALVFSSCYVANVETLSTLGAKLPGCVILSDEMNHASMIQGMRHSRAPKVIFKHNDLADLEAKLAAIPRDTPKLIAFESVYSMSGTVGPIKEICDLAEKYGALTFLDEVHAVGMYGPTGAGVAEHLDFWDNAAGGKAGSVMDRVDIITGTLGKAYGVVGGYIAGSARFVDMIRSYAPGFIFTTSLPPSTAAGARASIAYQREHLGDRQAQQRKVAQVKADLNAIGIPVIPNPSHIVPLLVGDAELAKRASDLLLTKHKMYIQSINFPTVARGDERLRITPSPLHTEAQLADLVRAVDSVWNELGLKRTSAWAEQGGHRSSGVGLAEPKQVVNLWTPEQIALADLEAARERALALGAGEQGGPELVSTPLVEGVTAGVAAAVAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B915</accession>
    <name>A0A2S5B915_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3583</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B915"/>
    <dbReference type="STRING" id="741276.A0A2S5B915"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01800">
        <property type="entry name" value="Ubl_SF3a120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035563">
        <property type="entry name" value="SF3As1_ubi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="638"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="78984" checksum="1415179D7DAB2728" modified="2018-07-18" version="1">MSEATLILPPPAIKAIVDKTAAFIAKSNNASMLEEKFRQREKTDSRFAFMNDSDPYHAYYADRLAAFKAGEQLEQKAEEKEGGDGKAAEDDGRPTEPPALDFLVEDPPKINAVDLDILRLTALFTARSGRKFTSDLAARESRNYQFDFLRPSHSLFGYFNRLVEQYTKILVPSKEFLGRVERRAGAGADSTNGDRVAQGRREVMKDAQERVEWEKWESSRRKEEEDKAEAERIAFAEIDWQDFQVASTIEFTENDEAGIAELPPPMSLAEVENMSIAQKKMAQMIMEGNGTAANGDGSDEGEMDMEDEDEDASAAGQPIVEHRKEDVVEIQTADSSAPVKIRKDYVRTKKTKPAQAFTTFEGQQIPVDEFGKHIRYETLDPRWKEEKRQADLNRAASAVMPGGTDVSASIRAIAAHRPDIFGENIGEAERRRQAEEMAKSKAREKNVWDGHAASKETITARYQTTNLDEQIAALHRAKFVLPTEDSNIGPTLPDTPQVPEPVAAATTLSAGASISAAPQPQQAVLERTTSNNFTAAGLPPGFAPQDANVAAASMQGGPPPAGLPQRPSVPGPGEALPSDGSAGLSAPAPPQGAEASPLGNTRPAPEEAEDEPSAKRARRDEGQVYPEEEWLARHPDPVKITIQLPDYPAKPAWGCKGQQVELEVPLTLLVGTVRDRVAALVGVPTGKQRYTYNDRLLANSSTLAALNLDNGDTLHLQIRDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B956</accession>
    <name>A0A2S5B956_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B956"/>
    <dbReference type="STRING" id="741276.A0A2S5B956"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="70"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="475" mass="52164" checksum="5157213BF746CA13" modified="2018-07-18" version="1">MPSVSQVQRIARPVLSDPPALSARGQRSLVRPPLLRCSLFNCQYNACLNQTGLLNLGVAENYGSALTGSLRLFAALRHFFGVYFDARTPVLPEHIIAGTGCSSILDALAAVLADPGDGILCARPHYNGFQPDFAYRNDVHVVGVDLPSGKEADPSSLEAFERQLAQCEQAGQKISAVLLCNPNNPLGFCYPRETLIAYCRFAEKHNLHLIVDEIYALSTYESDHPDPQPFVSILSLDPLVDAGCNPSRIHCVYGPSKDFGVNGLRLGVLVSQANPDLHVAMEANALLMKISSASVRWTADEPQEPKELELTGLPLQDVLWSNLLLDPVGLPTYLALNKSRLAEAYRRAITFLQKHAIPYRPAHAGHFVWIDLRRFLPTADVEGNRLESEAEQEVELVKRFLAHGINLGRGVAYDGKPGFFRLTFTLRPEYFDTGIRRLEEALGLGAETATDKGPTRELCSACEMSAQTKRFAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9I1</accession>
    <name>A0A2S5B9I1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetrapyrrole methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9I1"/>
    <dbReference type="STRING" id="741276.A0A2S5B9I1"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="6">
        <location>
            <begin position="326"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="615" mass="65673" checksum="28A11718C79BE907" modified="2018-07-18" version="1">MHAYPNPEPGASLILAFHPVPSTSTTPPQSILLLGAGRLTALRSFAALEAGYRVVVGVSSSQPWDPEVRYRIEEGQIERIDWDLAVDAGAEVWRKWFAATDSAGQLDGVRLVVLTDTVAAGGRRRDAVSARAFRDEAARRRFFVNIADHPTLSDYSFASTHRFDLLDSSRKSPLQVALTTNSSACRLATRLRRELVAAMPKSAGSAVAAVGRLRDELRGGAATDDDSEETLVLNRPVEQLTRAKSWALDEPSSSDWSTEAATATRMRYVSQISEYWPLDRLATVTANSLSAPSTPTRSPPLSSSYHDLAVPSDLALDSVTKKKGRILLLGTGPGNPLLLTRIAHLLLTTLDPTSPFYIDLFLSDKLVPSHILDLIPAERRKGVVIARKYPGNAEAAQEELMALAIEAASQGKTVLRLKQGDPFLYGRGGEEVLRFRAVAGIESVVVPGLSSSLAGPAVAGIPVTQRGVAEQVVVCTGVGRGGRTGSLATYERGKTLCVLMGVARLESLVAGLLDHGYPAHLPIALVERASAPDQRVVATTVSRIVDVLASLPAHRPPGMIVVGWAVMCLDGAGDMGILDADPATDPARVSQWLGARGYSVRDGLSDEWQGLLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA08</accession>
    <name>A0A2S5BA08_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA08"/>
    <dbReference type="STRING" id="741276.A0A2S5BA08"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="2">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="198" mass="21360" checksum="ABF3280709B4B9F2" modified="2018-07-18" version="1">MPAVLFVCLGNICRSPLAEAVFADIVNKRGLDIKVDSAGTAGYHVGEEPETRRPDRFDLQAACGPSTLKRAAAPSDAVDVRRLIRGPGAEVRLYSLRLHHRHGLDGDDFSLLHADVASTDNMHNIEKAKPANSTAKSKSGSWLYGRAIALFGSFGDGKVIDDPYYGGPNGFDKTYEQCVRYSEGLLQDMGYGSDGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA85</accession>
    <name>A0A2S5BA85_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA85"/>
    <dbReference type="STRING" id="741276.A0A2S5BA85"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="499"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 4 C-terminal" evidence="8">
        <location>
            <begin position="711"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="230"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="962" mass="103409" checksum="DEFA1D01B565E6D8" modified="2018-07-18" version="1">MSTVVARMGRKSSTPRRSDSVAVTSSISPTAPRNPAARSTRSTGQATHFRPLEGAPPVQRTRRPSAKAAAAQQVVTMSPTAANSRTVTPKKRSAPSSVATKKMAARPAKRAPALPTPEPEDGEKDEDAQDRQSSEDDNDGDDSEDEQELAGTSSPPARKRAQRTAHLPLPSPAATPPKRILVASPSKFAPKVPSPLKPKQRRTAPISSDDDRTDGDLMTTALDNLEDVFSSTPASSSTATTITTPRKSATSTPRTTPSRSSSISKSTPGSSSRSSSRIQHLPPAVVDIKNAPASLRSRLVGFHMEDEGYGVSKAATSTRGIDSASETGSDAGASDDDVEEQLMAQRRRDAKGKGRMMMDEDEHLDGADSPAMRDSSALLDGHDDEDAEMDLSLPIPPPQFSSDLALDEDDDDADVSQSIPRASTSAATALPAKSHPLLPSVPDKSYLASPLRKHILSSLAVLSGARLPLPAKLPEASTCDSIVSLPCMTGGYDEWERPLRSALDECVKKGMGNAVMLLGPRGVGKTMLVERSIKLLSHVHGSDAFVTVRLSGLVHTTDRLAMRSIAVQLAAQGFASSVGKEGEADDGDYSSNSATMATLLRLLEPSSPSNASTAANPQPATEAATPATSKPLVIIVDEFDLFAQHPRQSFLYCLLDIVQGNRRRGGVAVIGVSARVDCLSLLEKRVRSRCQSHILQMIPPSSFTAFCELGKRLLLVEDQQVAEQDWASAWNAEVERFFAEKRVVEYLRRMWSINGNVPTEIRSTLSHLLYRLDYDLKSLGLPENSPRLSIDMLKAQAKGEDKVRDDVLKQLSLPELTALVAAKHLTSSTLDRHAGFNFEMLYDAYIEHSRRVAASTSSSFALTHKPLSKVALRVAFDSLRSHELLLARTSSSTSGTAVTTASAGGGMAVAVPGSAAYVAAVARDPWKMYRLTVWAREVDREVEARGAECPLALRRWCKNWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAF4</accession>
    <name>A0A2S5BAF4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAF4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37825" checksum="8F1C11A6F0EE899F" modified="2018-07-18" version="1">MLDRLPLELVEQIVFDASPWTTAERFAFLSAVSKRYQEIFRPYARRYVVGNSQRLYHVVEGGSIDEDDVPLLGLLPSVETVVLNHAGGLEDLVQDDGDDDPDPYVVPVVVSGNSPFQPCRTLVIKNSDTWWTLEQSLGSQPFALEHLTVQIGSRTRVEEPWDLWQLVDAGVFPELKTLNLEVSDPPEISLSVLDKLDYIQAVFNSGLPEIWHIPSGFRLTTTPILYTVVRTSLGIGELRTEGIQYVYLEHYWDETLGDLGPYLEAFADLRAVFIMTMTCTCNRSTPYRWQNVASTCAGRPSDEYAPIEPDFIDYLKRNPHSPPPRRDSPPAASLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAN0</accession>
    <name>A0A2S5BAN0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAN0"/>
    <dbReference type="STRING" id="741276.A0A2S5BAN0"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="172"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="321"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="67935" checksum="DA187EB351EE9443" modified="2018-07-18" version="1">MTIEGEPVSLYVYDLSNGLALTMGRALTGRDVEGIWHTSLVLYDMEVFFGQGISIVTPPGTTHHGVPKKKLSCGVTHLDKETFLEYIENLRETYRAEAYHLLEFNCNTFTNDVLGFLNGGSIPADIRNQPTELMSTPFGQQMRPMIEQMFVGRKTPSAGAAVNNIMPHLGLAQSSRTADDVPTVQSVASNLQICTSVASMRTLLGSSLAVAVMFTSPTCPPCNAIKPHFEALARKHASSRKRIEFVLVETHVGAGAEVARSSEFGGPVSATPTFVFFHRGAQVGECKGANRQELATQVGMLELAAYPPHSHTKLALPALAKLSKSLGPITFTSFPPIDALSQKLDSSLSTSTLDGPSKDALAKRVPSYLRSLPGPPHGESRSPLPVGLLEAWLPATERAVQTLPSSAKFPIIDLVRLALARDSARLAASPAFVAYLPSLISHLATDLDHDEPERPYLLTSLRLVCNALVSNLLTARLLASDILPHVTRLIIRALLDPHDPKMRSAGAGTAWSVVARVYAARVGELDLSIEKSAQHALGGEGGESGEEWEAEMASAILEALAKETESIEVVHRLTATLGLLLYRSPYADEIRSLLEVLDIASTLDRKQAQAAEKGGAEVTALLKDVRRLIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAR7</accession>
    <name>A0A2S5BAR7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAR7"/>
    <dbReference type="STRING" id="741276.A0A2S5BAR7"/>
    <dbReference type="OrthoDB" id="2590590at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="951" mass="101130" checksum="E5379367FAA23085" modified="2018-07-18" version="1">MDSYGRSPVPKLGPRRSSLQVARDGHVAAPPASVQTAEPLLSACTAPGARPPAQVDDTGYYDSASAPGTPYGLTPAQVKPRFGKWGRWIEEKQQRRRELQQEEKAAGLSKSTSWSLPGQDDEGGRSASPLRRDPSALRRDEEAERSLSRDHLVLVTGADTLAGTSSTPAPSGGPASSLTRGRARTNSSASAAAAVQPLTMHTRIERVGERFSTGMPEQPLCGCPLPIGSQGATGRFTLIGTQSGLYVLDAQPHAGIALSSANGDSAARHHCLWTGLGVRQIETYAETDPYAETPRGLVLALVESPTGGDLEVRMWNLTSIVNLVKWRVYSATSVILSLEPEATATPTHGRSRSAFGGNAPNSPIAKKGTKRWSTASTWANSNRTNGLSASSASRYPPMSTSPPMGSSAHYSVRDLDLDSLESPATPQSSASHLALGGGSGTPSRPRSASETSHLELPLSWAQASVALPIPKSAGSIQFFRVFRRPPPKRRPKRNYHDPDPSDDEDDDSDDAWQAPRPQLGASDRVRPTGGRHHLYLLVATTRSIFLYESEPVERRTWHLAQEYFAPSTPRFLHLLRSSPPELSPDDFPELPTYLSFLLGTSHHVVMVRLSDSTVTELRVPGGIGAEACQIGAESTQSAAAADPKEGAANRKVQRSKSQYHRKASPSLAASLRDLNASVSRLFDGGDRNLPAGLRGVPSDFVKGRVVSEDGHEATEGSPGSGGASQSHAKWISCEELRLDRWDGPRRDRPQLLLLSNQHTSYLVALLDSATAESSASSTSHLSPVLLHTFPWAASAGPIVGVSAHVSPDVAPSTTTSHLSLVAFTGTGTIVTEHILSHPALAEVGSLTGADSSLTPTHRVVLPVPTSVPAPSQALHPIPHEDPDLSDRAAFDFGRRVGRICAAKTIPTLHAAAAGWSSSRGGEGGAQSVYFWVQGRAEWSLKQLVCGESAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAT0</accession>
    <name>A0A2S5BAT0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAT0"/>
    <dbReference type="STRING" id="741276.A0A2S5BAT0"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35113" checksum="CF6F2AA116B3EF0D" modified="2018-07-18" version="1" fragment="single">DQATGVQPFLYPLPPGNDVSSPLSLVLLPFSAVLGGARTLVFVLLLVAQTLLVEAILRPLELIPGVYAAVTRGINAGICRLLLAVAGIVWIQVDTIQLRKTGRSPPQVPFAPEKGDVIISNSSSWIDLLYLVFRYNATLTLPVSSSSSSSAASIVGWRRVSLARAIFSSGSLPEFGQEGETLAQLLENARGPVVVFPELTTSNNRAVLKVDAIATAATANAKPRQIYVLAFRYPAPTPLAPSLTHPIPTVVSPFFPLPLAHLYSVTSRLVPYTLTVRRLHPSESPKQLDWPAVAETLAATARLKRVGALGWKEKAAFLEFRKLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAV7</accession>
    <name>A0A2S5BAV7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAV7"/>
    <dbReference type="STRING" id="741276.A0A2S5BAV7"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="76"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="158" mass="17938" checksum="A94856F809A5BF81" modified="2018-07-18" version="1">MLASWQWGEEASEDELRWRANSTRVSTTPILLFAWRRGEGGLSQLLNKPYDAFADEGADEDTQLDAKAVKKQPDSIHIRIQQRNGRKTITTISGIPTDFDLKKLAKAMKKDFACNASIEEHEVHGQVLQMQGDQRQKSMDFFLKEGIATKETVKMHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAV8</accession>
    <name>A0A2S5BAV8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAV8"/>
    <dbReference type="STRING" id="741276.A0A2S5BAV8"/>
    <dbReference type="OrthoDB" id="3358861at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="824"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="870"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1092" mass="115487" checksum="454532530A0DB982" modified="2018-07-18" version="1">MPSLHDTRLLNNLLKTEKDTMQAFRQYTNTAASAGAALSAWSVADSADTGDLMDAAIRISQLLANCTDAQRLYLQALGTYRSSLKEIMARETALRTVVRDREILVNRLIKVGNKKPKEGHEREHEMKLEDAQRELQACETFLQEEEAALAHVKRLSFRESLNNRMKEMGHLAQVMEDSAAEAVAILDSLHGPDGDFTPSAHHFDLGSDDGSIAPSQSASQAMSRSSSSSSLADQHGRHANGPAVPEDLPIDPNARPTSVVRRERSFSPTRSPDRAMSQVSMAQTSASIAAPVRAPAPLDRPVMPAVPTAPPPIAHTVYTERVPGMPTFDIPRAPDLSRRPDYSSESEYDDDEQHGYGRGGGRNGGGNSRIQPQTSRRSMRFSSVQPPSMNFSPRSQRSYGRRAMSESGSIDGREGRGRKRSGSFFGGIARLFGRGKKRDEEDDELENDYGRGGGGGGGYGRSAAQDEYDYAGARSQLARQQPSAPSVRSRNTTVTDARVDAVMDSVINAGRISRPATRAGNDSSDDEGPTSVVRHVNDPKARIKAMSDVGRSPAPRPAFTVAQQQPSATHRPKLQRKGTSSSSVRPMSAVGAPASDVAGANQRRPRKAASDIGIPPSRMNPALSNSLSSPTLQVPRAPSGPGIAELANGAMLPLARPAGPAFAPRGANTGTPSAPAETGTLMRKKTKKTKVDPREAQLANIVATVGTVQPRARPVSQQRPPQQQQQQTVVISAESLGMPTAAGSTQPSTLARSNTSTSATLAQAPAANGTLKKKKTVVKESALPPSADDLAASLPRAATGPSSFSAQLPRPDDDPTTFQPGPPQSVAAPVAAASAKKSESAKPVKTLADKEKKSKQMTALHGVSDSSWVAAPSSNSTSAASTQRATAMPTPPRRSDVQKGDESLMSIVDIAEGNENVKTSRSYASGTVTPTGSTLTVPVATHGKATPSWLSGGNGPSSTAMTPQLSKRKSVRLAETDPNAKPVALSPSPSMRSTSSSAAAGQPRHGILVHNSPGSVAASLSNGTAGGKKEDLWPTRASFRQRMQDSDDSSDEGEGMRAYRAARKMLGKETRGMESAMQGSASREEKGKGRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAX1</accession>
    <name>A0A2S5BAX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAX1"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="317" mass="35946" checksum="BEB070FF0A613B84" modified="2018-07-18" version="1">MNSKPTIKIEQPSAGADWTHTAAIAIGNGDAPIPPYLVFATERGYVPPLVLLTNDELKRGAATSRGYLDFQFRPDWASQERPWERWLEAICWLSLDEFLPALAKLCFLVKATLCAAISTRETVDRDVGLFLGQLCVRLTVPGSWQTVRRYALLKLREWRQAIHQSKLWTRMVLSTWDECLWTKACTGSDEAGVEIVATPDEVAPTSEHKLLDMTHETAVEQSVPAHYRIQVCLRVQSWVIAQRLDLMVASNTAFSSVIKVICHHLGIIDVNLFRFVMNAQDWYGCMTMHELGPVTHASLFVVLRHTYKYLLPPRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAX5</accession>
    <name>A0A2S5BAX5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_3010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000032">
        <property type="protein sequence ID" value="POY73929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAX5"/>
    <dbReference type="STRING" id="741276.A0A2S5BAX5"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006338">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
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            <begin position="93"/>
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        </location>
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            <begin position="98"/>
            <end position="145"/>
        </location>
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            <begin position="98"/>
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        </location>
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            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="545"/>
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            <begin position="249"/>
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            <begin position="275"/>
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            <begin position="551"/>
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        </source>
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            <dbReference type="PROSITE" id="PS51294"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="594" mass="66443" checksum="AF7B550862A429D7" modified="2018-07-18" version="1">MTVTKRKPKPRETGGPDTVVTAPQLESGMKATCDACSTDITHTVHIRCAEKVGERLACPDFDLCVDCFLHGKSLGPHRATHDYRVISSHSFPIFNKDWGADEELALIEGAEMYGLGNWADIAEHVGGRTKEECYDHYMQTYIQSSDYPLPRIEHDFDPTDPEPFQARKKARLEELQSRPIPLPPPKPLASAPTCHEIAGFMPGRLEFEHEWENEAEMLIKDMEFGRVYHFGGEKQPAAVEPPVAPAPAAPAATGEEGADAAEGTATAEEGDVQIVDEKPLPDGEKEGDEPEAELDLKLSILEMFNERYDKRMAAKDLIFDRGLINYKTMSAIERKRAKEERDLIMRTKVFSRIQTSQDYEDFVEGLLYEITLRKRIADLQEYRRNGITTLAEADRYEQAKQQRLSFKASSYRESVSLSFDRSGAPGGRRPTPQSALIQQLKSRPAPPLTLATANSLQLLTPVEVQLCATLRILPRPYLFLKEVLLREWVRLKDRMNGTEARRVVLKEKNGELLGPAEGATGEWGEKIECVWEFLRDTTGLKDDARRYAADGDLDGEGDGDDEADDEEDFEMGDPRRDEDGVGAVPTKGTEGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB63</accession>
    <name>A0A2S5BB63_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="DUF7137"/>
    </dbReference>
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        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015521875" description="DUF7137 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="248"/>
        </location>
    </feature>
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        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="75"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="248" mass="25593" checksum="5DCFA02E7873CB54" modified="2018-07-18" version="1">MVRSRPSLLARLACSLACAVTLVRATTFQGAIPTPTPTLATLAFEIPAAHQHTLAARQQQQSSSATSSSVSIPQTAAAGGLTYLTPAQNAGPTYYKIASGNPLTFGWNYTSLYVTPTSLTFEARCSANGYTYPVGVVPGAQTSLTWDPWAYAQSPNAVPFAQASYTLRVYDSRGPDATAEPGLFNGANSILTFAMYSPAAYTPLASGWTCVGCSAAVRAFGGVASGVWVAVPVTVALVLIGGAGVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB97</accession>
    <name>A0A2S5BB97_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB97"/>
    <dbReference type="STRING" id="741276.A0A2S5BB97"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="290"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="354" mass="38925" checksum="48733E658E7DE566" modified="2018-07-18" version="1">MQAPVASRAPTSGPERRNTPAKYRDYQCFRPDGEVWCFCNTEPRIKAIRRVTRKESSPNLGREFWSCGNWVEGEACGFFLWCDQAKRMGRDFTTPPPPEPKNYVQPTDAQRRRPSPVAYSVPLAPAPPSPTSSPTKRPISERDLAVQEAVQGLDDIDFDEPIEGFDPDDDIVDDAESPATARSASPSKKARFESFAGPPSPQTPSRRAAAAGAIGTEPAQASGFAAIQADPDSPFHAIQKNLFAAPSSTIPVVTSGSSILSSPAKASNGTSQPDAFAALLNALSPVASLLDSAKKERDKEARLLLAAKRKEETLRKTYEKERDERERLQKENEALKNRIRLLEHELVELRIRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBA0</accession>
    <name>A0A2S5BBA0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBA0"/>
    <dbReference type="STRING" id="741276.A0A2S5BBA0"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="5">
        <location>
            <begin position="428"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="911"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1125"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1128"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1172" mass="129654" checksum="CFE42C9223CD7B58" modified="2018-07-18" version="1">MDADIASTLSGFALGEVFNSLDLDASALGAVQSQLGIRGNAALNRDAIYAEKFADDGLDGLDDENQDDLDDEREDFEAMIDREMREEREGEPSAAGPSKAPAAYTAAGRGTLLRGEEDDFDEDYDEEDGAGDTGMTDATPRVKEEPLEPAFGSLDQSATPGAVDSVATTQTDLQPQTQMSAIQLENLAPPPSRQVDVKDLFPTFEPGKTLAFTDLFAMRPRKKRRVVTEGVKLALPTLSEVPRMRSSRDALHGPLRPLPPSRDAAIRQLLLLSKVESMRDSGQAIEDLEGSDDEELRKAVERVNSRTQSKWRIPPDERVFDLNELDDWEDRILWGDSTSNPLSTFADPRQHRNALFDEGDWAKSILWDGENPARAEYFTRLNLNLNDTQMLLEVQRAAGEAAPKRMAPKNILGSAEMLAPRDANLDPFNLSNDREYEVPKEQKRQIIRQTFGALEVVHAYPAQKLQLPFYKTRLSKADTRSFHRPALQFPQNVPISFTKVRSKKKKDKFGRKIKKSEGAEAMRGMQDITLKDTSNFVLWEYSEEHPPIVSNVGMGSIIVNYYRKKSPEDTFIPQLELGQPLLLEGTDESPFKIFGFVHPGQTVTTLYNNLIRAPMFKHHVPETDFLVVRVTIDGDTSYYIRSIPHLYVVGQTYPQTEVPGPHSRKVTTLQKNRLMTIAFKLVAKNKDSRIKVHRLTRYFPDHNDLQMRQKLKEFMEFVRKGDNQGFWMIKGTVHIPNEQEMLKMAEPEMVCLAESMQVGLRALQDAGYADGAEEGGAGDDDSKLDTEQQLAPWITTKNFVNANANKAMLKLHGDGDPTGRGEAFSFLRTSMKDIFLRAGESMEERLVEMANRPKSAHKYNVQEQQEIYREEIARIWKSQWDSLTNPREPPLTAEDEDRHRGNLAALKKAASRLAGGNADTPMSLPGTPGPAGRAGTPLSRAGSVDLDDGASVTSGRGGKAKTLRIKRLVAGRWETEIVRDPSVIKAYVTQRRVIDEEKLEADELLPSDDESKNERRKKRLKEQLEKLKRNQERRLARKNQKLGIAPGQMGVGGKKAVKTETTRICGNCGQRGHMKTSRKLCPRWAEFNQPKNTDTSAALPTNFGGGLALPPMGAAKPKLKVKLGAGSGAAASPAPAAATDSAAPTPAATTPAGPAASAIDPALSAPGGAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBP7</accession>
    <name>A0A2S5BBP7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBP7"/>
    <dbReference type="STRING" id="741276.A0A2S5BBP7"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000257">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000027">
        <property type="entry name" value="Calmodulin (CaM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000100">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="113" mass="12805" checksum="A9B3C57D261781C4" modified="2018-07-18" version="1">MRSLGQNPSEAELQDMINEVDADGNGQIDFPEFLTMMARKMKDTDSEEEVREAFKVFDKDGNGFISAAELRHVMTNLGEKLTDAEVDEMIREADVDGDGQINYDEFVKMMMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBU2</accession>
    <name>A0A2S5BBU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBU2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="132" mass="14631" checksum="72411CA300F995D6" modified="2018-07-18" version="1">MQGALASTVFLPDSVRKLVIAVSRDSLKALSLVSKHWHSLVEPALWSRLDYKPKPLAELADASLNLIQRIGMHVRTFTATRWYLSADFHPIMGAPAEEEQALAKQSSTCPDVASTRILRSNGASAWPSYRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBY7</accession>
    <name>A0A2S5BBY7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBY7"/>
    <dbReference type="STRING" id="741276.A0A2S5BBY7"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="143"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="442" mass="50810" checksum="A6EB2AEDE4B56F18" modified="2018-07-18" version="1">MSDPGPSTPRQIPCLTPEQATYGHFRSEHLLPNTPCLFPASYTRDWPIRRYIAAEGGSIDYEALEQRFGSLKVSCAECGGVESAEVLSKSAEPPIDNFLDLLRLWQSGRGRSKYLKDWHLPLAIHHGGARNPDGDKRSVIRKGKERVRDELYEVPPVWLDDWMNEYEGSERDDDFRFVYAGGGDTFTPLHRDVYWSYSISTQLFGRKRWYLFPPDCTATLRPLLKAAEREDTSVNCDAWSDASKAEFRERGMVVVEQEVGESIFIPSGWYHSVHNLTHPTFSLNHNWANAHNLAAIYRSLSDEVTRCREAIADVREMLIDAVRRRGGDTGPEGEWRGEWEETVNRLVEQSEGWSWPTFWRMTRHALSNLGLSLAEVEARADESRWPTVPSQVRPPVSFVIEQVQPLVDDFRRRQEAEWRWLPGLDEVVSRVEHELQRLEAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBZ0</accession>
    <name>A0A2S5BBZ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2718</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBZ0"/>
    <dbReference type="STRING" id="741276.A0A2S5BBZ0"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="88"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="182"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="288"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="564"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="683" mass="75692" checksum="D5D49CA629BB7AEA" modified="2018-07-18" version="1">MLCTSCGEDAVLEMTEQAQTVCTRCGTVLFENAIVSDIQFGETGSGAAMVQGSYVSHDQTRARAPAGYRQRGIATQESREQTLLNGRRRIMELATGLRLSEHLQNVATRFFNLAVNMNFTKGRRTQYVAAACLYAASRQSNGTQMLIDFSDLLEINVFTLGSTYLKLVRELNINIPVVDPVIYITRFAALLDFGDETQKVALDATRLVNRMGRDWMQIGRRPSGICGACLLLAARMNNFRRSIEEVVQVVKIADVTLRKRLAEFKETASGSLTVSDFRTIWLDETADPPAYSQGVKKEEADRHARERKLREETGVSESDSAIGDRAFRELADREQTAETEEAASPRRSSPAPGKENDGQGEIEGDMAPPPLPSAKALGKRKRTMADQAEEEEEEGNNADAPSSDVVDELLEGDEREQYEAVIEGELQQYLGSEVGSKLQAELEGQEERRLQKISQSPAVYDYDQNDSLEGLDEDELDAFILTPEEIEIKSKLWMQANKDYLKELAEKQTGPDGEVKPITKRPRKKTKPRDGQNATGITAADAATKMLEKKKFSKKINYDAIKNLFNTGDSDAGSAYGGDDDDEEEAPLVGQVYGNSRKGKRSRIGTPIQTPEPTWRQGSRAPSETPGRAQQQQRGRDADDGDEGGDDDHVAHKAPANEPEDDWRAQFGGMTQQEDDFDGYDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC03</accession>
    <name>A0A2S5BC03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC03"/>
    <dbReference type="STRING" id="741276.A0A2S5BC03"/>
    <dbReference type="OrthoDB" id="2530395at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="567" mass="56027" checksum="88A22B8CA1C6ED14" modified="2018-07-18" version="1">MDVAEPPPKRIRLSPPPLPSSNSAREPVIADSTDPSPAPPPAPPAATTAEELPPPNPGAELPESVASSPLSAINSDGDLPRSGGHEDTTGMTTVEDGEPKEDDAWRRGGGPADETGDEGPSSTAVDAGEANADDTDADATPVASTPAPPLVGSATALGIAAPSESSPLDSGTRQEALSTRDGTTDDPQAAPQAVDTSAFGDPVATPGSTAAALTAPATEETLGSLPPPQPTAAASIAAGPVSSPPVQHASAPGAAPAPVEEEAVIPSALGEDALMADALAAASGGLQGGTAPLANAAAESPAAAPATAAIASVQGEAPLKDSTASPAADPTGTDQTPPDPLPPPASIPSEPASSTQPQVEALASAASSNAPVVAPPAAESAPVSAPENPAPFADASNPAPTPAAIPQPAAVPVPIRVSGPEPEPEPEPEDPFTVPQSEAYRAVRAASQWNSLLGWARSVRLESSPGGAERGWDFATGMYHVPRNSPAYTANVPRATPESLAASSSKKPLPALSLHSTPSSMLYSQNPDVANLSDDDGPGTGGVGTPSESLFTESGRPRRSRAAMTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC38</accession>
    <name>A0A2S5BC38_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidophosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BC38"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1205"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="624"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="865"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="910"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1250"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1329"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="950"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1253"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1329"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1357" mass="146481" checksum="000C55D69E1EF385" modified="2018-07-18" version="1">MCGILAILLASQNNVAPELAEGLQLLQHRGQDACGIVTCGPKGRFYQCKGNGMVRDLLDAKSLNQLIGGMGVGHARYPTAGSSAHAEAQPFYVNSPYGIVFGHNGNLTNTDHLRYYLDHYGHRHINTSSDSELLLNLLADALQKTGKFRIDEDDIFRAVRECMQNASGAYACSAMIAGYGIFGFRDPNGIRPMGWARRKSETVEGAYDYMMASESVVCDALGFSDWTDVKPGEAIIITRESGLVTRQVVPQRTYAPDMFEFVYFARPDSVIDGVSVYRSRMAMGDLLAANAKAKLELEGIKCDVVIPVPDTSRVAALQLAQNLGVPYREGFVKNRYVGRTFIMPGQELRRKNVRRKLNAMALEFAGKNVMIVDDSIVRGTTSKEIIQMARDAGAKKVIMASCAPPIRWPSVHGIDMPSRRELVAHNRTEDDIAEYIGADLVIFQTLPDLIKSCTSLNPDLKEFECSVFDGNYLTRDIDEAYLDHLEGLRNEAAKSRTAEQKPMVTVNGSSNPPPDVSGGGETACGGGDEGGEELSGTALSDPPASPPRAAAGATKHSPAEDCATVKMASVRSGAKPALHLSLAPNGSESVPGTPGAASRRVPSWGSVTSSETYQRLATYGNQSMTALPSPLPSPLPSPLEGQEWGFLSNQPRRNRSDTGGTGTSWLDGWGGSIGTNGTQRTVQDHEAAAPGPSEFGAFPTASTSTLPADNSPPRDDGRKPPERSKTLSFFGTSSTTDDSARALSPPPNPPSRQNSLRQRPEPSATLPLPPSPGWDHVVDPLRSSVASSSGGSWMDHSADDKSSWRRGRGSSIGSLASNDGSISRWPSLRASTGRYASPERGDLSFTSDSEVSDLRPRLAALNTTALSPSIDQSPATAGGATLPRPMSSLPSAIDGPASLPRSRFITLDTVDSASPTTPFARRGFVDLDDEPSRQSFHSTQSSPRPAADFVGRRSTERERPRPPEAEDDPDDALQLQRGDTLGEFVIERLLGKGAFSRVALARRSHAVAQVRDRPGHSRTASRDGGGDGGLVALKLVKRKSCEGNERMRISVMREVEVLKTIQHPSLVAMFHSFSTPIYTALVLEYCDGGELFDFLASWHPHLTEPLARRIFGELCSAVGWMHEICLVHRDIKLENILLTARPFPCADPSAVLATLPTPFIKLTDFGLSRFVNPASPLLATRCGSEEYAAPELIMGKMYDGRQTDAWALGVVLYAIVTGVMPFVEAVTGGSRARKAYLLKIAKADFRWPGQAPLSRSSSLSTAAASTHSRGVSESTPAPKSGSASSSPHMSRMVTPAVQEVVERLLVRNPAKRATVSQVWDMEWLQGEGRPERRAGVVRRPDLGLSRERMASETWDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC67</accession>
    <name>A0A2S5BC67_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC67"/>
    <dbReference type="STRING" id="741276.A0A2S5BC67"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015447110" description="Nitrogen permease regulator 3" evidence="4">
        <location>
            <begin position="23"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="5">
        <location>
            <begin position="770"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="621"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="715"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="836" mass="91838" checksum="EE3169D0EF88AA7A" modified="2018-07-18" version="1">MASLLALLLVAKSSAGAQLVYAYPPYPRAVPRTHKPVYAGRRKTVLHAVYNSSSSSSDGDSDSDDDDDDGEYRGPDSKSFLGFPDPVLAALLSPSRELCDQPFELVVDHLAFVGHPVWLGDDDGGRDHPGADPAHRTTAADDGDDDDGDNDSLESRGRSRRPRTSFGRSSFSASEIEEEEHEHPSDEDRDRERDATVGPPASRTASAPPRPILIAEGNGGGSGNSPKRPDLLARSQSSTATTLHPGSSLISSSQHSQASLTSLSRLTSFNLLCVVDTPPDSHLSSHLEGYYKDLVLPVTANIKALEKRDHWLGKEAAKLRRAREAALEKGTPWDDFLATLPAKSSLAGAISQLYTALKRNELAEVHIGPLPVQVLLRGELPVEDEFDPAEREKFLVAGPDHPDLASPERPDRSLSPGGHAYARHHQAAPLFSRMRRRPPVRFEPWESLLLLEDARVLQRDVLEDSLLWRFLDICRPTLSFAEYETLLDLESEDHVLDDVVDHLVHWNKARVISMVSLRSSYVVSADFEPKKLVQLSITFREAFPTMPSLARLLSHLSPKEPFSTIIPGAQRPTYLNALIWLLRNQLVTKQRTFVRILASTELKQATAAHWDRTALQSGISLASSSRPDDASQLSTSAGAASEHSFGASSRRSDGSKLPRPNLSSSTRPDYDDTRGMVIVSGSAVSGGSPRDALLPASMALSQSQKSASMFATRMADRRRRPTGAGMGTRSQHSGSGFRKGFSTATMSSQSERPDETSSTPSVIVEPGQPSMLESRWLNEMCRDKESSLVGKFERIVRLLNGRHHLDEIRYRSKLSRKQLQTVLTAFDDHLVFFHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD31</accession>
    <name>A0A2S5BD31_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD31"/>
    <dbReference type="OrthoDB" id="2529079at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="442" mass="48060" checksum="07903A3A59BF36CE" modified="2018-07-18" version="1">MSRYNGPPRHRPEPLALGAGPYSIQSQQYPQQQYQQQYHNRYQQPLHSAPLPNMSQHAYAPLQPSRLQSNPQTAAALAEFQQAQQVYLAELNRTIEHQIAVQQQVEREAALRLLSIQQQQRELYGLQQGPASAGLPNCGHGQQHDQAFLRQESQYQQQQQHQHSSLAQQANPLVASALARRQRQDAAAHGFPQQTSHYRDQRGYDQAPHQFQHRTTPSPPAVILSAPGEPYPDTSSSGSDSGETRPTSPESSVVQAAPKRDEVKASRRRSHLDALTHTVEHAEQRRRRRPVSIAGPADLPNGQQQATRGLQPRWPGQATGHGLGGPLAPRAVSDPLLSPRTPNYRHGSTPPSSASSATTLTPSNAALGPPTARTGPPPVPGTASAIRQPRGPPTDLDAAQTNFAQRIRARAIGSLKVRSGRNSDDADQPAPLAAGLAGLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD78</accession>
    <name>A0A2S5BD78_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD78"/>
    <dbReference type="STRING" id="741276.A0A2S5BD78"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="226"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="624"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="981" mass="110115" checksum="23EC91E42A911349" modified="2018-07-18" version="1">MSERVRTDSRVSQRPSRPGSALSSASQGSRPARPASAATTAYSTSTALQPPPPLHPKTPKPSAARYGGLAEKELQKLQSSIRAATKTGAAAGGLNAKLRQTRPSLVREVDERDEQAGAFIADASFSRAPLNSRVPPVSPHRLAAKRLAQPRASVASTGTRPPPRRSVPDAEEDEDDIPDSGSVIEEEEVDEETRIKREKQRRKQLGLEKEPLIGLNAELQEALISEDLLFVLTGIEGRYIEFDPSYTPQDDYERLQGAHFVIDPQLDPRIASLVARFLPLATYYTAITAFIEEYSLLEHGTVNHALCAAIRDMLTDYLVLIARLEEQFNYSSSFTLQRFWLLVHPALNTLALVYDLVNEIVELSIPSPEDDDDDEAKEDDDSDDGFGAGLGDMLAELKAATAAAKPASESKTAPWRLGPSLGGETLFLLSNLLTRTAGNPAAHSLYSHLLLRASQPYARILLGWISTGRLEDRWDEFCVREQGGFSTGTLDADYTDEYWERRYTLRNRSTTASAAASSAAAMGKAPVRSFSLDDRPRERGLAGGAVIPSFLEPWEDMILLAGKYLNVIRECGIEVEVPLDAGSGGEDEDGLVDMQDESFYKRIEAAYTYANKTLLKLLLEEEHLLSRLETIKQCFFINHGDVFTHFLDMAKQELNRKKKRIVQERLQTQLDLALLRSTPSGGQGQAGSDGFKDDLRIVFENVTVADWLLKVVNQTGALVGPDGAPVDMHDSGKRSGDKQAKDAPEPIGWDVFNLDYSVKFPLSLVLSRKSITYYQMIFRHLLRLRQLERIFQDTWTEHLKTPSWRNRSPYPELQSWKGRVFALRARMYDFIQQMFDFAVSEVLEVRWGELRKKLERCETVDQLLKDHDNFLNTCTNECLLTNEKLLELFHQKLFNTCYVFANYTTSFTRIVVQTEAQANGDWARLGGKFKEHWDFLSRFEKHFDHFIAMALNHLELHAARENSRILPLMVRLSSLKGKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDB5</accession>
    <name>A0A2S5BDB5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2224</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDB5"/>
    <dbReference type="STRING" id="741276.A0A2S5BDB5"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015436219" description="Laccase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="152"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="378"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="69599" checksum="0D6D0DF4005BFA6A" modified="2018-07-18" version="1">MRGTLLAGALLASAVPIRAALVERWLNITYVTASPDGFEKQYSVGTNGTWPPPPLEVRANDTVRVHAHNSLDHPTSIHHHGIFFNGTNYYDGAPGITQCGIPSGESLTYEVPVNLQHGTYWYHSHTGVDYQDGMRAPLVIHAEKEAHDYDDEFTIVLSDWYHERANKLNNKFMNKFNPTGAEPVPDSLLIYASHNGSYLPAADNVKFNENLALPFEAGKTYRLRVVNAGIFAMTFFWIDGHDMRVIEVDGIDIEEFPVNHLTLAVAQRYSVLVTARNDTSQNFLMHANFDSSMFDTVPEGLQLNYTSSVSYAAGNPMAPAETRGMELMELMDDFNMVPIVAQPQLIPNTHTELDVWFDAYDNGVNRASMLDNITFAMPETPSLMTMLSMGNDSFNPAAYGPQTAARVLNKFDVMDLLLINFDANAHPFHLHGHTFQITRRASDVTSSDPALNPPHTHNATNPMRRDTIVVPAGGAVNIQWTADNPGAWIFHCHIQWHMESGLAVVFMSDIEGAQQSLTLPQALKDQCQALGISPTGNAGGKMSLTDFGSAPKGPHDQANITGWTPKAKGALAGCVITAVLGMLSVVWYAVGGQLDVEELEEEVERDMAEKAAKGGGYKKRMFNAIVGKKKPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDD8</accession>
    <name>A0A2S5BDD8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2237</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDD8"/>
    <dbReference type="STRING" id="741276.A0A2S5BDD8"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="551" mass="61463" checksum="B161264AD2DF245D" modified="2018-07-18" version="1">MSVDWGHYPSWAKLQKLYDADHTKLVLKELFDADPKRFEKFSREYNSPQKDVHVLLDFSKNLINDDVFSTLLELAKEGGVEQARDEMFSGKHINTSEDRAVLHVALRNVGGEFKIDEAGADEVQGVLDRMATFANQIRSGEWKGYTGKAIDTIVNIGIGGSDLGPVMVTEALKPYGKEGLTCHFVSNVDGTHIAEITKQCNPETTLFIVASKTFTTQETITNAESAKEWFLQSAGDAKHVAKHFCALSTNKKAVESFGINADVMFPFWEWVGGRYSLWSAIGLPIMLFIGPENFQELLAGAHEMDKHFLETKLEDNLPVILALLGIWYNDFYGAQTHALLPYDQYMHKFADYFQQGDMESNGKFVTKDGRRVTYQTGPIIWGQSGTNGQHAFYQLIHQGTKLIPADFLAPIETQNPIRGGLHHKILLSNFFAQPEALAFGKSEDEVRKELGEQASNEALLKSKVFEGNRPTNSILFQKLTPRTLGSLIVMYEHKIFVQGCIWGINSFDQMGVELGKVLAKAILGQLDDASKVDGHDSSTTGLIKHYITRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDE9</accession>
    <name>A0A2S5BDE9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2247</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDE9"/>
    <dbReference type="STRING" id="741276.A0A2S5BDE9"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="211" mass="22076" checksum="88F59038DB1EC32E" modified="2018-07-18" version="1">MQNDYQWLLRRTAVGHSPLGGDLADSEGGAADVGGGRRRHSRPGGGKMAAIINYRVRVTLNDSRALVGQLLAFDKHMNLVLAECDEFRRIKRKGGSKANKAAGEGDDEDDEDEMKRTLGLVILRGETIVSLIEGPPPATEEKGLAGLAPGPGFGAPAGRGMGLSAPPTMRQAPQSFAPPPGMGMPPMGMPPPPGFMPPPPGFAPPPGFAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDI1</accession>
    <name>A0A2S5BDI1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDI1"/>
    <dbReference type="STRING" id="741276.A0A2S5BDI1"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="801"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="838" mass="89833" checksum="7D80F1CDE89AC16D" modified="2018-07-18" version="1">MNGHQPLPLEAPYAQPSPLTAPRAQPPPSQIPTERLANTADDWARGSTASPAPPPAVTALQSDSGVPLYAHMQPNGQAGMPYGAPYANGPAPPQAPQAYLHPYPQQPSAQPVANPYGASPSYPYSGPSQQQQQPQQPYTAPPINAHSRPASFGQPPPPMTPVPNYGAPPPPPAPQGAGAYYSYPQQQAIAPPPQPQAFAPPPPLPQQPATYLDPNGGQVSRPPRGASMQPSDFAAMQGGMEAMRIGGPSPAPAMASTSLSRPNYYASPEDGPPFKLSVTPPDQAMLASMRETAVAGGGDMARKVAWAKQVLKFIERHQSAAGESSRITDPTLVRWTDEALNYILASASSPAPVPLALYLRGDLSSTGSFPSYRSKDTKASFRDFEAAANAGYHKAWFRIGRAYEDFGDVRRAVGAYEKGVEKADCGSTYRLAMAYLLGQIGVVADIPKALALLRRAADGADLDTPQPPYVLGMLLSGEFESPGVTLDKSQIPIDLDEAKWRVERAAYLNCGPAQYKMGYAYEYATLGCLFDPLLSVQYYALASQNNEVEADMALSKWYLCGSDGNFDKNEALAVTFAEKAAARQLPAAEFALGYFHEVGIGAPINLEKAKRWYERAASHGNSDAKGRLDALKRSSQAALSRTDHDSHVETKLVRKRTQAQARSDEQRERIAASKLKASLSGQPTPLRQSQGHAPPPINVAQAQNQYRPSSQQPLRQSTGSSYPSSTFRRQNTIRQVEAAARMNTGPPGTPNPARYPQGPPPPQQPQQHPSGPRPLSYQLTDAPPSNTPQARRPSPQSAGRPQAIQMQAKPAPQQKPATFAEMGITTQKAKNSDCAVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDJ3</accession>
    <name>A0A2S5BDJ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDJ3"/>
    <dbReference type="OrthoDB" id="2528475at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="441" mass="48270" checksum="240C105F16A7C682" modified="2018-07-18" version="1">MIPSRPVQAVEQRKQSVSERLARLRAEQTARDRPRFSASTHASLPNSANARWLEAATNAARHADIRTVSRPVDRRRGTAGPPPPKSWSTDSNEASGPQSRHRSAKGREDQRDLRAKVARPLPGRGDDTPSPKGLYTAATKVVAEDLSHGPDSLLADFIDYLPLHLRLRILDVYADWRNELVLDDDVLRAVLIAESAGRFPDGLVPAGAVDGISEGVARMSTLEPASESPGAGDDWESAPWHDSAGHDGTVESLDLSFSAISLRMLRSVLLRDYDDTTSVSSSAMQAKPRASAPPQAPCPPPKFVATFPGLHTLNLTSTARVPFSDALFDTLSHLMSLRHLSLNGKSLSAPSGSTSTSVGILRLAAATPNLQTLDLSYMDLDHSAIARSLDWNERWLDLRVLGVRSDSDDISTRWKDRLKRDIQEAVASCKRRKRRWIEVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDJ6</accession>
    <name>A0A2S5BDJ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDJ6"/>
    <dbReference type="STRING" id="741276.A0A2S5BDJ6"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04646">
        <property type="entry name" value="LbH_Dynactin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="236" mass="25383" checksum="3BDCCDBE1028D4AA" modified="2018-07-18" version="1">MPSDIVDAFKVGAKSVIVADCDLRGNVTLGAGTILQPRCTILAVAGPIVFGENNIVEENAVIVNRNQEPMLIGDNNLFEVGCRVEAQSIGSWNTFGIRSRIVSSVMVGNHCVVGSGCLVQADPFASPFRHPEPLHDARDSSQPGTEGEPTASTPAESREEGVSELDAQAAGYPTSAAPSTRSTPADCLSDYTHVFGSENRRRKAGEEGGGQSRALFVKHWEYLRETLPRYHPLKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDM7</accession>
    <name>A0A2S5BDM7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDM7"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF17">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="890"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="965"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="999"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1019" mass="108242" checksum="E6131C637FE9D1E3" modified="2018-07-18" version="1">MSTPVARSYLEDDVDPLKSPSRARGAHDGTGQGTAEDYDATSSPLGPPRSAAAAAPLTPLSFKRKSTARHSSSGAAVRDKAAHLIGGILRTGSSGQPDSTSPAFRRTDAPTHIALPKNAIRHKPSFSELSQAIASDEEDEEDEGETTAGESPRQRRGSAFRRGDATDRDRQRRLSAGKRVSSKGLGLGNRSRRSTGTGAFGSPSKEPGLVSPLWGNHPYGDGGDDDRPSDGTVLADGALLEVTPLPKMPIFVLSICMLGEFLSASVCSPFLFFMVESFGVGRDGGGESAVSAWTGVVAAVFFLSQFATAMLWVSIAEKHGRRAVLCASLVGNGLTVVAFGTSKNLGTAICTRLAMGLFNGAVGVARSAVQDVTDETNRSSAYTILGLLWGMGGIVGSVLGGTLEHPADKYPSYFGESDLFRTYPYLLPCLVAGSVTLFGGVLSLFLDRNGGQRTGGIHLPTEKDVETATGLLGRVKDALVLRVRSLLQRFPHRPPIQLNQSTGNVSLRSAHAEVPPLVSPEPSPAVSPGADGMSERNPLSDRRGSVRQYGSAYGYSTSGRHASQSGFERDSGLRIPSMRRRGYRSVSMATSNRYDPDNEVNHSFAERLLLANNQAVFSLSDVFLAKAAADDQFTAIEAEGSVFERDEDEESRIEGTDMDANSEYGDIGFGTAPPSMEDLRGAAAQQDIQRAQDQVDGAAVPRPTSPSLLAVQRRRPDLLSPQRERIASYAPSGPRLRRFSGASSIRPMSIYSNTGLAPESLAASAAQLVAVSAQQPNESAFAPMQAIPETRAPSIIEHSSPQSEVAGPTAGSLVWQLPLAMIMQYLCVGLHGTACDQLFTSFLVAPIASGGLGLTADHYAMLVAIMFFFSMVWQFKFYPTVGPPNGPLSHLSMFRIGLILYVPVYLLFPELRGLIKVEGETGLVMLGMVVLSALRYLANACAYTAVMVLINVMTPAELVPLANGLAQSCISLARFIGPLLGGSVFAASIADPQNANPAFGFRLIAGLCFVGFLLSWRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDY9</accession>
    <name>A0A2S5BDY9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1954</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDY9"/>
    <dbReference type="STRING" id="741276.A0A2S5BDY9"/>
    <dbReference type="OrthoDB" id="5576752at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10164" checksum="63D78EFA0F99CD55" modified="2018-07-18" version="1">MSGRIPIMRAIVLIGGVSALGYGIMAATTPTDQQFYDALSPDLKRKVDEARALKAGARDELARASQDKLNAIREQARSDAPVWADAPQDPKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE04</accession>
    <name>A0A2S5BE04_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE04"/>
    <dbReference type="STRING" id="741276.A0A2S5BE04"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="92"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="719" mass="78704" checksum="95A2460914D7986C" modified="2018-07-18" version="1">MVQIQTVEVGDVNPPAGQGRARRYYKAVDALVESPGAGISVIPDLLDHSVKTRPTLPAVGWRDTLHLHTEEKDVKKIVDGQETTEKKKWTYYELSDYKYLSYAEFGDLVANLSNALAETGHSRDTIFNIYAQTSMHWFAMANACAKQSVTFATAYDSLGEEGLEHSLNEPDVYGMFTNSNLLGTLAAVISRTPTVKTVVYDGPASDIKPGSLEALKEAGVKVFTWMEFVELGRGHKHPEVRPKPDDVACIMYTSGSTGAPKGVEITHRQIVAIVGGTIKLVAHLITPDARVICYLPLSHIFEMALEFTVLYAGVPMGYGTVKTLTDTSMRNCVGDMRAFRPTIMTGVPTVWELIRKGILQKVASGPSYRASLFHGAVGLKRWTKSIPLVNSLVGGVLDTVVFKAVKQATGGQLKYAINGGAGVSQATQEFLSYTLTPYFIQGYGLTETTALSCILPPQIVQIGVVGVPNLCNELQLRDFEEAGYKADGSGEGANGLPQGEVCLRGPNVFKGYYKRPDLTKEALTDDGWFLTGDIGQWNADGTLSIIDRKKNLVKLQGGEYIALERLESTYKSCNLVLNIAVHADPNASKPMAIIVPHEHNLRKLLEAEPDLLGAGKNVDHLDWATEVCQNDRVLKRVLAELNATGKQAKLKPLEASYFGSCCSLPIAPTHRVTRLQTLQTVILSDFEWTPQNGFLTAAQKLQRKTILQHFKDDISKVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE12</accession>
    <name>A0A2S5BE12_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE12"/>
    <dbReference type="OrthoDB" id="10611179at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="165" mass="16928" checksum="AD5A67728B324B9D" modified="2018-07-18" version="1">MQGSPAATAPTPRQASLAPPPLAAQQPTASIRTTTSGIHLENPTTEATRALALCSGPNGLVETVERDLLKLVQQAKRAYEGTGTPADPHAALASLSALISLLSRSALGGFVPPSSSSQVPSSAAPSGTVISQAQLDQASERSQALFKELQAVRERAEVVRAGLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE53</accession>
    <name>A0A2S5BE53_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2042</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE53"/>
    <dbReference type="STRING" id="741276.A0A2S5BE53"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="66"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="587" mass="63642" checksum="C17D1EA620F738DB" modified="2018-07-18" version="1">MADSSLPASKTTTLAGSAAPSRAASIEKDKHANAPHPPSRAASTFHVQDEAEVPTKDRAPAFAVALCLFQSLAGLLFGWEQGVIAGLLTNNAYQQRFGEPDAASPSGYSLPSTRQSLIAGFMSLGALFGALMIGYASRRVGIKYSYLFSLIIYMGGIAIETSGHSSWVQEMMGRFVTGWGVGALSLLAPLYQAECSPKHLRGLITGTYQLAATLGIFLSNACNYSLHDRGDDFSWRFPIALQFIWAAIVFAGTVVAPESPRYYVQRGHLDNARINLAKLRGLSEEDPVLLAELDQIVKGVEDEKLAAQSTYLDCFRPKDRMLQRTMNGILIQMGQQWTGVNFFFSYGPKFFAASGIKDSYQTQLILSGVNVIGTFPGLFAVDKMGRRAVLFIGSAIMFSGQIIAGAVNTARPNDPAAGKALIFASCWFIFGFASSWGPLGWVVAAEQFPLSIAPLCVSLATASNWVNNFLIAIIVPYITDAGYGNLQSKITFVWAGAIALFTVYVFFFIPETGGLSLVQVDEMYLTGVPAWRSSSWTPYGGATARNRDERMDEAKRLKLGNETTHHETVARRDLGDEEAVAESALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEA6</accession>
    <name>A0A2S5BEA6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEA6"/>
    <dbReference type="STRING" id="741276.A0A2S5BEA6"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="479" mass="51513" checksum="BAE414D106D0180A" modified="2018-07-18" version="1">MAPSVSEQISNAFVNLGLAAKEVPTKSNGAAATISSADAVALEEQYSAHNYHPLPVVFERAEGVKVWDPEGNEYLDCLSAYSAVNQGHCHPHIIKALTEQASKLTLSSRAFHTSSLGPFTKYLTELTGFEMALMMNTGAEAVETAIKVARKWAYKVKGVEKDKAIVLSAENNFHGRTIGIISMSTDPEATNDFGPFVPGLGTRCPMVGEEGRIPYNDVGAVERALEKHGKNVAAFLVEPIQGEAGIVVPDDDYLEKVQALCRKHNVLLICDEVQTGLARTGKLLCFQHNPAVQPDMVLLGKALSGGVYPVSCVLSRRDVLLTIKPGEHGSTYGGNPLACAVAQAALEVIVNEDLSARAQRLGEKMRAGLRALQSVGPQGGWISEVRGKGLLNAIVIDQSKSSKGRSAWDLTLVMKSKGVLAKPTHVNIIRLAPPLVITEEELDLVLQRIKESLEALDELDVIPGADDHHKAEDEPQVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEU0</accession>
    <name>A0A2S5BEU0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEU0"/>
    <dbReference type="STRING" id="741276.A0A2S5BEU0"/>
    <dbReference type="OrthoDB" id="428177at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015516888" description="mannan endo-1,4-beta-mannosidase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="11">
        <location>
            <begin position="159"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="480"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="495"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="571" mass="60696" checksum="24CCA002F4A4ECA4" modified="2018-07-18" version="1">MYTLFSVLLAATLALAAAPNPHQIYALQSPVAAEAAMVRPTDVPTAHDWIDRIQPQPRDRMRRRHFLGGGGHGRRADVPRERALRKVELEQRSLAAGLERERERLAMRVNDTASTAVLVERDVTDAPTALEKRGNGGVWTGVSSYYLFALDDPDRHAVLDAIKGGGFSVVRIFIASVGANNKGSSCRAVNDLEPNQVGVYDDTILSLIDQLMADCQQRGLKLLIALSDRYALGFWSTDSYATQLNIVAPGSSGAQKVANAATFYTDNWAISMYDKRLTHIMTHANPLLGGQTWASLSSVIYAVEPQNEPQGHMLMASSTWACDRAAHLKSLITSGILVSSGGGITTADSLGSWAMSCDSFDVISVHDYGTSASVTAGALAAAQASNPGKQIIMGEWGMAGANKASLVSAFVSAFADHGLSWMYWEVVRPGQASSDFEIWTDEPAWSALTGNGYVAPAATTPSSQAWTSSSTKAWSSSSAAWSPSPTWSPSPTWSPSPTWSPSSSAKWTADAPAWSPSPSSSTAPKWTPSSDSPTWSPTSTTTSAATSPVWSPSASPKWTTSSRAPSASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEW8</accession>
    <name>A0A2S5BEW8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="5">2.7.1.36</ecNumber>
            <ecNumber evidence="6">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">BMF94_1683</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34 35">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="26">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="25">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="5"/>
    <dbReference type="EC" id="4.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEW8"/>
    <dbReference type="STRING" id="741276.A0A2S5BEW8"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23 34" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="32">
        <location>
            <begin position="606"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="33">
        <location>
            <begin position="772"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="POY75312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="915" mass="97050" checksum="DFD6E034D248C3EE" modified="2018-07-18" version="1">MTGMSTPRSTSDPLSPASPASLTSSLLRARPYRFATLAATVDNPDPGHKDQYGSSSVPIYQTATFKGMGGQYDYSRSGNPTRSHLEHHIAKISNARHAFAVTSGMGALDVIFRLLKPGDEIIAGNDLYGGSNRLIGYLKEHGGITTHHVDTTDPETLLPLLKDESHKIAMVLLESPTNPLLQIADLEEIARLTKRYRPEAIVVVDNTMMSPYLCRPLELGCDIVYDSGTKYLSGHHDLMAGLICCDRDEIAKGIAFTINSIGNGLSPFDSFLLLRGVKTLSLRIDKQQANTILIAQYLDRLGFKVNYPGLASHRGKAVHDRIASGPGAVLSFETGDVALSERIVASTRLWGISVSFGCINSLISMPCLMSHASIDPAVRAARNLPEDLIRLCVGIEDPADLIDDLEAALLEAGAVRTVDEASTAARGERLNLERIGVGRADDLSKGLAGLGLDGTESAPGVCRPKVETIMTSAPGKVILFGEHAVVHGVTAIAGAIDLRCYCLAEARADGLISLVLPDMAYSQTWDPANLPWDKVAPFPPPLSAVLKSGPKGDVVPDQELLTLLANQYISHEAGQNLKAVQSAQAFLYLYMHVASVTGLRPSQTNTIRAGLPVSAGLGSSAAFSVSVASALLYSHGVLPVPGQQSPATPHSVESEHAHLVNSWAFVAEKVLHGNPSGVDNTVSSLGGAIAYRRAISGRQEQSLKILKGFDEVPFLITDTKVPRDTKTLVAGVARRKLEEPDTIIPLLDSIQRISDQAEQVLSAAGAHSRSEQVATLARLVEQNHSHLVSLGVSHPALETVRNKTRDQPWGLATKLTGAGGGGCAVSVVPDGFSNDSLLSLRSALADIGFETYSTSVGGRGYGVLVPPAAGSADEQVESAEGGVEANAIPGRKRFEEAPAEDLARWAESAGVWACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF55</accession>
    <name>A0A2S5BF55_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF55"/>
    <dbReference type="STRING" id="741276.A0A2S5BF55"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23417" checksum="E4793CAC6BAECA43" modified="2018-07-18" version="1">MGGGGVGKSALTIRFVHQLFVEKYDPTIEDSYRRNLNVDGVMVSLEVLDTAGTEQASSYLFRASRPVFMSLSSMYMRSGDGFLLVFSLTNSDSLLELHAIHEQIQRIKETARPPHEKARVPIVLVGNKLDLVSERQVNREAAVAVSQSWGGVPYYETSARREINVTEIFADVVRQMVKSDLAFDSQSNGTRSTRNGHAGHRARKKRCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFA0</accession>
    <name>A0A2S5BFA0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 4 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFA0"/>
    <dbReference type="STRING" id="741276.A0A2S5BFA0"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF630">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="4">
        <location>
            <begin position="228"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="5">
        <location>
            <begin position="513"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="699"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1036" mass="114546" checksum="52C5A6828C050C82" modified="2018-07-18" version="1">MATPTTSTSGVGNSVTRLHCRKPSTGLAVPMPSARAGSSSASFGPGHAKVPLPHWPTTGTMRSRFTASAFILLALHLLIAWRSWGSEGGGSHASDDYRLPRDGQDGHAGSWYGGKRGRTDGNGTASPGGRWRETGFAQQFLPAALRDAGSYWPGDTLTSAFRKSTYLSRRKVSLPFDLSPEPLPIHHVHEQIHFHNTPVSKHRPASNQFVRAKDSLTHMQGGAPPVISIITATQNPRPVMLDTARSVLGQSLQNLEWIIVNDHTTSLDSLDLLREIAKDPRVVVIDNDGEKGLSASRNVALRYLLGDDRRKKGTIPKYLASLDDDDLYEFTALEKVVWMLESNPSWDLGGFYVIKFAASNETVTSGLHSGAANFFSGNFVPNAAVFTSRAVIKSACRYDTVNFAVGGEDWDFWLCLAEHGYWGGTAPEPLYWYRGNPASFRKQRWGNLFVDGFAPLKAKIDDKHKELVKSGKFPDIPARPSRQLDAIDWEPPYDAHLARVDKSIMFIIPWLYVGGADVGALHQIQIFAEAGYRVTVVCTLYRNPAGLELRPHVLQYTHDVHVLPSFLNAADQPRYLKHLIESRGFDEVVLCNTQLVYEMLPALVEEVPHVKFIDYLHNEAYDGWKSGGYPTYSLLSQRYLAKTITCSSYLRKWLIDRGHRRPGSIGVVKLGIEVDDFKPTAPAIKSREKQALLDVEAGTVVISVVGRLDPQKRPELVPDIAYALRKLGNYKAGAFLIIMLGDGDLKDRVKARIAELKVGDFVRMLGTVEQPRDYLALTDIFLLPSMSEGISIAVAEAMAMALPIVTAKAGALPEQLGYEEDDPSLVAGILIDHKLDADTDAPLYAKELHRLIGQPGLREQYGRAGRRNVETTFNWGDTLSGMFGELEKARVPDPRQARHMPHPAAHYAVQNLLLESHDETDFATIQQSLKAPVRSGVGRTLQDRCGESTEALTQWIDALSEPHRCPDSVIKAPLDSSAIQRSAKFQCGAWCIFDLTRKEYAGWGFNGACFTPFDDTEQGWCKQFWSSRPAVNLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFL3</accession>
    <name>A0A2S5BFL3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFL3"/>
    <dbReference type="STRING" id="741276.A0A2S5BFL3"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000004">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="21"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="589" mass="67987" checksum="766FB05807865EBB" modified="2018-07-18" version="1">MVNAPKKQLPSWWKDGVVIYQVYPASFKDDNGDGLGDLRGLINKLPYLKSLGIEAIWLGPHYKSPRKDEGYDISDYKNIHEPFGTLEECQELIDKAHSHGLKILFDLVINHCSDQHEWFRESRKDKSNPKRDWFYWRPAKYDADGVRHPPNNWRSVFGGSAWEWDEATEEYYLHCFVKEQPDMNWENPEVRQAIYRDAICFWLDRGLDGFRIDTANFYSKHVDFPDAPVVAPNTPWQPAADYMTNGPRLHEFLREMRKEAFDHYDCFTIGELPHTPRLEDILSYISVEAEALNCTILFDQMDLDHKGGQYPLMRTSWKLSEFKRLAAFAQQLAEPKYNAHALSYMENHDQARSVTRFASDAPEHRVASAKMLATYLLSLSGSLIVYQGQEINTINAPKDWDIDAEYKDVCTINTWREIKEDAEKNSDPSLLERGREGIQLTARDHSRTPMQWDSSHNAGFSTKEGAKPWMRVMESYKEGINVAAQEDDPESTLNFYRRMLALRKEHKDVFVLGKFDLHDKENEQTMIYTKTSQDGSRVALVALNFTSEPQAFDVPSSLKDKSTGKLLFSTVGGKSDGKLEAYEARVILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFP4</accession>
    <name>A0A2S5BFP4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFP4"/>
    <dbReference type="STRING" id="741276.A0A2S5BFP4"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF108">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="390" mass="42117" checksum="66FBB884F73A9702" modified="2018-07-18" version="1">MAFAHQVGGHAATILASPLSSSTLIKPASDRELEFYQRVGPRLADGQLVGEWTPGFYGTLRSHRPPPAAGSGDGTAAQEDNAAVLLRQPDMLVLENLTHRFLRPNVLDIKLGTQLYDEDATDDKKQRMRKAAESTTSAATGIRLTGFQVWNRDTQAYVQTDKVFGKSLEADELALGFARFFCPPDSPLSRAEQRIIDITDSTSAKEPSVGSDTGSRADESSDSLRTHPAGPPALPTDLLLIVLRTLLRRLKQLIALLSTVEMRMRGGSLLVVVEGDPDALERAVLRLAGPQRAGAPAPQSQRGGAVVRQAESEQAAADDDGDDDGASVSTTDEEGNAKRETLLPLEMRLIDFAHTRAAPGEGPDEGVLLGLRTTERLWGELVAQLEERER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG72</accession>
    <name>A0A2S5BG72_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_1179</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG72"/>
    <dbReference type="STRING" id="741276.A0A2S5BG72"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="712"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="356"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="473"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="602"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="602"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY75769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1168" mass="127891" checksum="43AC35A191578B35" modified="2018-07-18" version="1">MLAQSGTLTPLKQEQHTYGAENGSASGIYSTSTSSRRAIPPSDGSAGSFSSLAMTAGTQLMPNPMPPARTNGKGREPPSYDTQSRSTRASGSAVPPALTRPFGQRQDSSDLPVNPLFGLGEQIRVKETGSSRLLVQKAGNVVREGYTARSVTPPDGKSSRQANKERPRRPDDHDEHWHDRILAKAHEWGLAGALVDEQDDYDRGRTLYLPVPSTSAQAAASIPAEANGDRHEGYATQVENFKDKEDQQDHFDAARMKLRGLHSEVHELLENAGFRTPNSEKRPQVNSPQLAFVHDDRPVSPAASSLQHQSSFYSATSDIYASASETGHTSFEVPDDTAIIPLRTDSPLSFATLSEGAASTSTYSPRTTAGTANGAKTAHPEDPASGGPTSGVNGAADSGSISPSASAVPSQSAPIPALVVADATPPPSRILPTRRSSRLSQSPPRTAGEPYLGPPAESVAPLASPQVQTYPIAAPTPRRSVTADSSALLTTPPMGSDSPHSSPATITSRRFSSTSTSTGRLAVPGMTPRSQSFSPGAPITSSYQLETPEHAAHTGPGTHPTTSLSYPPVGLATQPLLLDDVESSIAAQAEMIRRQRQEKRLEAEKEQAKRDRALQLERERAAGAKKERRPSEGSMAAPIEDKLPSGPGALIRRRVTRMGSGSSQADASGSAVHAREASANGRDESAGRRGRGGSGHEGDRAAAGVLVGNLIGQDHANYVLMYNMLTGIRIGVSRCQAKGKRPLTDADYTARHKFSFDIVGNELTPSVKYDFKFKDYAPWVFRELREYFYLDPSDYLISLTAKYILSELGSPGKSGSFFYFSRDYRFIIKTIRHSEHKFLRSILKEYHEHVKKNPHTLLSRFYGLHRVKLPRGKKIHFVIMNNLFPPHRDIHETYDLKGSAIGRLYPEDKAQQNPHATLKDLNWVQRHRQFWLGPEKKVLFEEQLRRDTELLQRLGIMDYSLLTGIHNLFKGNSEGLREDKLTVFQPDAVKVSRKATQVKRDADATALRKAVERSDPQALGGKHELPQTDSSERRLFIFYQDEGGMRATGDHNEELGVIYYLGIIDILTPYTLVKRIEHFFKGMKHNKHMISAVHPREYGDRFLAFIKSSIRGNDESIRPQMYEHERKRATTRPADPEKSAVVAVDDGSGPDRPLDSSAPHTTEKVKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG78</accession>
    <name>A0A2S5BG78_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BG78"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="6">
        <location>
            <begin position="306"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="6">
        <location>
            <begin position="358"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="7">
        <location>
            <begin position="580"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="923"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1188"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1214"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1363"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1466"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1546"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1409"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="930"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1053"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1188"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1238"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1260"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1298"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1379"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1466"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1551"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1593" mass="171873" checksum="BCD5AE38F881B5F6" modified="2018-07-18" version="1">MSPADGFAESLDARLDPAIVPEHYDLTIRTDLCDLTFSGAVEITFRTTNSIPYLTLHTASPSVLTAAVLSPALGTKGSRTGRRPALRIVSDQKKQRARIFFEGGDIAAGRYRVGLRWRGEIQPSLVGYFSSSYAKKGQGDHKAFYAITHFEPCYARQAFPCFDEPALKATFKISLISRTGTVSLANTDVDSIEHLGEGGNFPRTDLLDEQFFATETAKDTTANGSDAATPHNVAAITTRQATDYVKDDWEIVRFTLTPRVSTYLVAFANGDFEHIESQFTSKLSGRTIPLRVYTTWEHIRHARLLLQVTEKVLPIYEEIFDIAYMLPKLDVLVASDFNGGMENWGLILGTSRVYLLRIWFGNVVTMEWWDNLWLNEAFATLMGEVIIPARIKPSWRMHSAFIPKHLAQALSLAALRSSHPIEMPCPDEETIQQIFDALTYSKGASCLKMLSNFVGEEKFLRGVSIYLKKHLYGNARTQDLMAGISEASGHDVGKMMDNWLSKTGFPLITAEETEKGIKVRQHRFLATADATPDEDETLWHVPLQLLVVDPKTGKSKVHSELVLSERETTIDIDDVANTTYKLNAETCGVYRTLYPTARLVKLGSEAGKGSSSAFPLNDRMGLVQDAAVVARSGYAKTSAMLHFLSQMKDEEENLVWQEIASALASIANTWWEQSQDVRAGVSHFRFQLFKPIPTKLGFEYRHSDDPDTTELRTTAHSVLADSDDAETLAEYQKRFALFVSKCDESAIPNDLRNSIYAHCVRVGSEVEYAKVLDVYRNPPTAAHEEAAIRALCYPEKSDLIARTLGMLLTDQVKSSNLIHFYSALASNRVARRPLWKHFQQNFELIVSQFSGGYTLSTIVRASFETLTTEEDAGEVEAFFQDKNTSAFAQALEQGLEAVRANAKWLDRDAGDVEQWLLSRPPEAQRRRVLGSTNDLSNKSSPTLPSARPIRAKVDLSAASGSPNAASWTPTQPVRARVAVPVGASPRAGGYTGSPSTPSATNAVFPRVGGSSVVGGPAGQRGTLSPQTPTARGPSPTRARSPDAPTVRPGVLRASTSAARIGGSPNTTPRGDAAHRAPPLRGQQAPFPTSTAPFLPSPSAAASADAYLASVSPRDFGSPTLRSAKPAAIAPSTLTSAASTVSLPALSTSPGSATSSALASPDINAFEYTGTFRSGHFGAESARMVATTSRSSAGSSVGSTTESRLLPPFALERKESTSHFVRSSSQVSLQQPPPPPRSPSQRSFPAPRAPSANPLRSPTLSASTAAGRPPRSPSSMSISFPRPTPPVPTTTQRRAHTRSQSAASLSSLSSIMCGPEEHVSPIHTESQQVPSSTWSYSGGAAAPALPGNVRPPLAALDWLVAAAEEEPSGSSPGNSTGRLSNGSVGQVSAVSSAESEADGLEKEAKVDRRIADLEIRNASLLTINADLEREKVKHRKEIRDLRRKLRESIGGAGLAALRAQMSHVDEGIEDDADDDGSGVEEGSDGCPALPEPTWPEILEGDPAFSAVAATLEGLLGRAKRAVAYQPAGADLASRVLSAVEVEEQFAIRSNPASTSTSASASDTEDSRPRTLSRASSMRGLAIEGWSASRKPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGQ7</accession>
    <name>A0A2S5BGQ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BMF94_1043</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BGQ7"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140327">
        <property type="term" value="F:flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000023">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1247"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1276"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1326"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1362"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1389"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1424"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="447"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1213"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1501"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1589"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1539"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1613"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1641"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="741"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="741"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="874"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="915"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="938"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="973"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1053"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1054"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1055"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="POY75959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1651" mass="183621" checksum="CCD081207ED11D86" modified="2018-07-18" version="1">MSSLLRMRRDHRRQDSAMSGQFDPDSGRNLSDMTHPEYDPATDPELRLRVVHTATQSLHSINVEDDRRRFKRLASRRAKRTSESAPSGTSLKPRKTLFGRRRTRAATITSENSKEGIEEEEGDATVEIDYEAREKLEQQNTRLAAAAEAEECARRQEVTDGSDSDAIRKGGKTQKKGGWSLRRNQKPKERRTVWVNVEGVKTDPRGYERNKVRTSKYTLLSFVPKNLTEQFRRVANIYFLALVVLQVFSIFGATTPQIAMLPLVAILLITGIKDGLEDARRHTLDNEVNNSAVTRLGDWTNVNVPEDDRPWWAFWRRANPNHRVSKGVRKLRAKEGAYDATFLYAANPAAIESRETLGDSSIQIAGPTARLRGDSAASALHGSKADSVHSLESFANDTSIASYPPRLMRNGPSGSSSYAASALSRSARSMKAPDVVTYDQATPGTAKWERTLWKKLEVGDVVLLKENDQIPADVVVLSTSDSDGVCFVETKNLDGETNLKPRKALKATMGISNEEDIEHARFWIDSEAPHANLYSYSGVLRYRSREEKLGMEHPIVEGKEYHAGEELQEPVTINELLLRGCQLRNTKWVIGLVVFTGADTKIMMNQGETPSKRSKIEKETNFNVIVNFLILLCLCVGCAIGGGVYDSMTGRSFDYYEPGGEYASSTIANGFITFGATLILFQNIVPISLVITVELVKTIQAFFIWQDIDLYYEPLDLPCVPKTWNISDDLGQIEYIFSDKTGTLTQNIMEFQKCAIGGISYGEGITEAMLGAAKREGRDTSAVDPAQNVGMLTQRKERMLDTLRGGFKNRYLRADKVTLISPPMAEDLVAKGSAQAKALSEFWRALAICHTVLTERSDEEDPNILEYKAESPDEAALVSAARDAGFAFVSRTSQAIIIEALGQPERYVPLRTLAFNSARKRMSSIVRTPDNRILLICKGADSVILQRLRNDHDQRVIERTSQQLEDFANAGLRTLLISSRYLAEDEFQRWSKIYDNACAAITDREEEIERACELIEHDLTILGATALEDKLQEGVPEAIAMLHQAGIKLWILTGDKLQTAIEIGFSCNLLTNAMEIMIISAESQEGTRVQIQEALEKVNQSRGGLTPLNTDGGEKIDGAVKKGGFAVVIDGETLRHALDETLKPSFLDLTTQCNAVVCCRVSPSQKALTVKLVKDGRGAMTLAIGDGANDVAMIQEAHIGVGIAGLEGAQASMSADYAVGQFRFLTKLLLVHGRWCYIRVADMHANFFYKNIVWTLTLFFYQIFCNFDATYLYEYTLLMLYNLVFTSLPVAILGILDQDIDAKTSLAYPQLYRRGILGKEWTRRRFFGYMLDGLYQSAVAFFVPYLVFAWSTTLTRDGHDFALWELGTTVAACAVTAANLFVGLNIRYWTWMVFVIIIGSTLLFHVWIAIYSQFQTFFFQNEVIYLYGTAQFWFSIVLVQIIAIGPKYLTKYIRSTYFPRDNDIIRELKVVGPSALGHRNDVEQFSDESVVSSAVGEQPERQALVRSNTPAQQPLPRLGVVGGNPSWVDPALPSPVPSTTPAYRSTETSPQAQTPSRFLDTGLTEVDLLARSPLDAAHRQWRNEVAREGRTPSLAGSHPGSPQPGVASPLHSPPTSQNHSVYTSPLHSPPTPAYYSPPEGQEQQPGTGYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGT1</accession>
    <name>A0A2S5BGT1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1049</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGT1"/>
    <dbReference type="STRING" id="741276.A0A2S5BGT1"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="195"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="461"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1114" mass="122593" checksum="830B51DED9998EF3" modified="2018-07-18" version="1">MDDDLFASFSKPPPPSSAHPAGSTKLDSSAPLGNDARAGSSRHAATATASKAKGAKGDKHGAKAVKRPLSPQDPPVDQDSLKKLKQDSTATGTMTSGTTVGEPFAVTDELEITAQTTVRPSAGLGGGAGGGAAGAGAAEGTTAQEEEGLVLQHQVRHQVALPPAYPYTPISSHVPPAEPARTYPFELDPFQKVSVASIQRNESVLVSAHTSAGKTVVAEYAIAQCLKQGQRVVYTSPIKALSNQKYREMLAEFGDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEIMREVAWVIFDEIHYMRDKERGVVWEETIILLPHKVRYVFLSATIPNAMEFAEWICTTHQQPCHVVYTDYRPTPLQHYLFPAGADGIHLVVDEKGNFREDNFAKAMGALGGDSKGEDPASAISGQGRKGKSKKGATKGPSDIYKIVKMIMVKNYNPVIVFAFSKRECEGLALQMSKLEFNTDEERDMVQTVFMNAISGLSEDDRQLPQIEHILPLLKRGIGIHHGGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMPAKTVVFTSVRKYDGRDFRNLSGGEYIQMSGRAGRRGLDDRGIVIMMTDEKLEPAAAKGMVKGQADRLDSAFHLGYNMILNLMRVEGLTPEYMLERSFYQFQNTASVPKLEDELRQLDEQRASIVIPDEDNIADYYDLRQQLDILNKDLRDVLNHPSYALPFLQPGRLVRVKHEDLDFGWGVVVNYQKRLGSKGKPLSADEPPQNQYIVDVLLHLAKGTAPGPVLPKNKGTASSISTIQPCPSGEEGEFAVVPVLLSTLDGVSHIRIFLAKDLKPLEARMQALRSVKEVKRRFPDGIALLGPVENMGIVDEAFKKLLRKIEILESRLISNPLHADPNLPALYDQYAAKETLKTKVRATKKKIQAAHSVMHLDELRNRKRALRRLGFATNDDVVEQKGRVACEISSGDELLLTEMVFGGVFNELTPQQCAALLSCFVFDEKSEQTSKLSEELAGPLRIMQEAARRIAKIAIESKMTVVEDEYVASFKPQLMDAVFSWCNGAKFSDICKMTDVFEGSLIRVFRRLQELIRQMSMAAKAIGSEELEKKFNDALACLERPSSVAFAASLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGT9</accession>
    <name>A0A2S5BGT9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1062</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGT9"/>
    <dbReference type="STRING" id="741276.A0A2S5BGT9"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="146"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="535" mass="58913" checksum="47E8FD28A7BF2B7C" modified="2018-07-18" version="1">MPASLTLRAATRSSIAPVPTLRNASSARAHITMSYRSALFTSAQYSTSRGERDPEYRVLRNERMNKNVLEAQYAVRGAIPLRAEELRDHLEEHGDKAGLPFDKVVNCNIGNPQQLDQKPLTFLRQVSALCDYPDLLDHPSTPSIFPSDAIARAKSLIGDIGSTGAYSHSMGNPAIRKRVAKFIEDRDGHPSNPNQIYLTAGASTGVSNLLQVLISNPHDGVLIPIPQYPLYTAALALNAARAVPYFLAEHEDWGLDVKDLRANLEKARHDGTVVKAMVVINPGNPTGNCLSRQNMEDIIQLCYNEGLVLMADEVYQSNVYKEAQPFISFKKALKDMGAPYADNVELVSFHSISKGQSGECGRRGGYFELANFHPEAEEQIYKLASIQLCPSLQGQIGVEVLVNPPKEGDESYPLWQAEVGGISDTLRKRSEILVKAFRELEGITCNDANGAMYLFPTITLPPKAIEAAKEKGQAPDAFYALQLLEATGICVVPGSGFGQKPGTWHFRTTFLAPGTEDYVNRLKKFHDSFMEKYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHF0</accession>
    <name>A0A2S5BHF0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000007">
        <property type="protein sequence ID" value="POY76197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHF0"/>
    <dbReference type="STRING" id="741276.A0A2S5BHF0"/>
    <dbReference type="OrthoDB" id="2525765at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="808" mass="86702" checksum="914A0DAEB4060FB0" modified="2018-07-18" version="1">MNDSKPKKPPACDRCKAKRVLCHPNPNGCPRCVEKGVLCTTTPVQRRKRRRAGELDVDSGRSSREPTLTLPEVPAGAAVAGTAAGPTPQSDLLHQAPPDLSTTFETAAPRPAAAVSAVPLHDTSLMRYQNLSLPFFRDDASTSHSPAPSFYGAQQVVLLPQEPVLTPELAMALYEGFRQSTRYDQPLMQFTTVHSALTTNSWFIDLLPPATRALALATFAIGSLYTFDPAIIGPSPFRSYSDIEWRGRDLRPYGRKRRRAFEGLRDAALRAAKENEVTVVPSVDNAACCVLIDVLLQMDDTAQSRLLGARPYYRAYVSHVTALVATGNAPVSDMLGGGTWAIHLSSDMWSELCSGRLTLTPEDQKLLLERDTVPDVAAIKKQYRDLLTTSKLEDWPAITPFCHLFMATARSLVSELLAPHLRNRDIDPAVLTRLVQSIADVQEVSILHRQLWSRQIKFIEATIPAPGADTSTPPPLFQHANSRRIRWNRLQAARGARDFGAFLWASMVVPLYREVRRRANVTTEAEREAASPSFSHAYRAEQLKLLVQQARALVVAAVETHIQLFESTPGMALLASTSATGIADAFELFVDLVENCDLPRDDKVASLAASAAEVLKVGGWVYASTRFDHLIASLEDLHGSLSPTSIPGPGPTETTTKSHQWAGPPLDVADSPLPPPPPTTMTGDGTGALPQIDLEQYAHISSFDPLSPSWLFAAGIADAVSGGGGDSAAQAFATGSQAPTSPDLFASVVTGGTDWAAAAEGTASEPGPMTVAGDAASRLFADLTSQSDAAFVASSTLAAAQGAGQGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHF5</accession>
    <name>A0A2S5BHF5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHF5"/>
    <dbReference type="STRING" id="741276.A0A2S5BHF5"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="96" mass="11587" checksum="73816770E5A39101" modified="2018-07-18" version="1">MVYTLVCHVLVKPEHVEDMRAELRKATSIYSQDKETIGWHVMQHEDDPTKFAIVERFMHKDSSQEEHLSNPYWKEFNPTVEPWLAQPIEIRRYFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHM1</accession>
    <name>A0A2S5BHM1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHM1"/>
    <dbReference type="STRING" id="741276.A0A2S5BHM1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="351"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="511" mass="53718" checksum="49D66CC9E11EDC60" modified="2018-07-18" version="1">MASSALMPSNAANIPAPDDRPVVVQCPYTLSSCPLFNPTFTTAEVLDAGRGAGSGCGGVAPSPRERDPPETLASASTARLSQSPRRYGLAESMRKAASPPSQTLQLDSSSPFQYIDFPIAPLEEASTPRCPAQAATSTRPYGVASGPTTPPEGAARSQLEAGKPVVSSAQPAYQYQPSQLPLYGGLPGRTRMASGSDSAYGGIYDPSYASTSSLARPQTTATYTGGTYPAITMPRQYSADSPADTALPSRDSGYADLGQPDLSVAYELAGMASRSRASLSPLSPVSYLARSAVQTATGADGTLSSGVALPFVEQDRCSSNSRASSAEQQVEPGEAPGQLYAPGPVPGQPKAPTPFISKLSHLLSDSSYADVIRWNEDGTVILYAHTSPRLLDILGRFFRHTTVSSFARQLNIYAFHRLNTSELLTQLEKSRSVGVRGCASEWSGFSHELMWRDGPNKPTCDLGKLKPSGPKTEKGKQNLAKKLAENGGSVKKRRKTGPSTASAAAAKEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI55</accession>
    <name>A0A2S5BI55_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI55"/>
    <dbReference type="STRING" id="741276.A0A2S5BI55"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="161" mass="16783" checksum="28900CC7BCE2E2AE" modified="2018-07-18" version="1">MLSLLSSSRAIRSSPIASLASLTVTVTGRRAASSLLTPASHPSTCSCARCATRTSPTSSIPRPAQPSAAARSLSHLVANEAAHPRSCGCARCAPRTIAGNGGILGAPSRPSTATAATVSGERGMKVRSSVKLYCDGCQSVRRKNRVYIICRNNPKHRQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI61</accession>
    <name>A0A2S5BI61_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI61"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="84"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="819" mass="91797" checksum="B843FA296891A13C" modified="2018-07-18" version="1">MVAPQRARLPRKAASAAVSYADDDAAGDSSDPDDLLAPPPARSPKKGKAKGKAPAGGVYLWKAVPDGLFCNEDAKQATLTRKRVDFSALLPTEIVLEICAYLLPPSLHALARVNKRLYATLTSETGSAMWRRKLEAPDEMPKWMQAIFGTADRRTVFEDSDDSDAASVGSSGANTAAQRRKRQADKRKLPLEQQKPLSPFKIASLYHYSECQICGSDKSATIDTNLLIRCCQRCIDAQAIPLWKITSDEDLDDDLADLHRSVSAIVRTTWSAPSGLKPRDRRGPYALACDLRKDSEILEALQMEDDAERARAPTASANVLEDRRGSGRRSIRTLAVSKSKSPRVQAYVERRQKQKEERAQIGRWLNSYGADAHKTEDERREGRLFDLGRIDARLAEIMERVTEEKLVKGDFVISSLVDAYTSLETLDSKRIPDFSLHPLVKSPEPLTDEGWTEVAPRIYKDLGRCIARNIMVEHNVHAVTDLEFDWDKVMPALLAQPKKLDDAMWAYVQPELVKAIERQKEYAVSYQKRLAEEAVTNKELEVVHRKQAFFRSRLTKIRDGQRNDADRSLLPTLSDLIDLPTVCRLYDDEEYAIRAGEEEADLAVWGEHLPAILDEIDDWKVHVRLETLRMILAATTDSSEAKLGAIDADTLNDPAFDDDFFRRPTSWVNCSTCTVYRSLFDVLKHRHASVCLLNRLRSPKGAATTRDTEPALAFPVDLSLEVACTILSICELGGASSDEPYKSTEAFAWRLRRDKMAWKNSPTGLTAKMGWLSLIGLVCREARKAHANDELLEVPEIVMTGASKRELFRRAQEQLAGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIC5</accession>
    <name>A0A2S5BIC5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIC5"/>
    <dbReference type="STRING" id="741276.A0A2S5BIC5"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="325"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="671"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="356"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="724"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="830"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="843" mass="94171" checksum="620AECFF439F5A34" modified="2018-07-18" version="1">MEADLARPPAPSRSGSSATAARRNLRPTAGASAAARTRSYAQQQASERGQLNQSVTKWQEWEQHATDLGYDWIIERDMEAFRQALSDEPSSNNNNNNSNDDQPEKIIAASDWAPVKEARRRRGGGTGAKPKKRNDVVREGWAYHISRWPLLGLIFFIIFLEFVAYLLVRQAVNTIEFFAGWRGERGRLRHALRNAKTYEEWKRVALELDALLGLNSWKQSAPNAYYDAPLVRRVLKALRDFRAKDDVEGVCAVLHACVRNNFAGVESFRLYSESYYGTKNLVQEYLDEVSSSLEYVRNASTDDLPADEKADFFRSIAKNLGASALCLSGGASFGYYHFGVVRALLDQNLLPRVITGTSAGAIVGAICCTRTDAELRELLQPSLADRISACEEPFRVWAARAWRTGARFDTVQWARKASFFTMGSMTFKEAYERTGRIFNVSVIPYDTHSPTKLLNYITAPDIVIYTAVIASAAVPWIINPVVLLRKNKDGTLSAAEFQGRHKDGSLRVDIPLHALHLLYNVNFSIVSQVNPHVHLFNYAPRGSPGRPVSHRKGRGWRGGFWLSAAEQYWKIEMLKWFRVIRDLELLPEFGGQNWSTVFLQKFEGSVTIWPKSRLKDWTRLLTDPDRDELARMIRVGQGVTWPKIKMVENRLKIERQIDLGRNEVRQLLDSDGATSDRAEPAKSGLATPALLSASRRSSSDRLFRLPNEQTSTMQDEDDDEVPSRSLSRADSPSTPAQRRKAILDRLGLQGVGSRGASGEQLSGNGNGRSGSGEGEGERWTDGGESDWTSGGEGGGSVTGMTSSEKGDAIPRNLRRRIRRASMSDFGSALPRRDPMSSDDEAYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIF3</accession>
    <name>A0A2S5BIF3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIF3"/>
    <dbReference type="STRING" id="741276.A0A2S5BIF3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015690651" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="641"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="674" mass="68605" checksum="38CA23C70276955C" modified="2018-07-18" version="1" fragment="single">MWRLSLALLAAASAVTAQQTVNPNVPGYGQISCTNYDGTPNYASAPTTGTLPALSSGNYFCGILGSQCSYAKPCDGSVCNGVESGNGHCGGGYSYGGYCAGSLQTSPNDYICGGIDDAGGAGCNDNYDCISNYCDPIGKTCRPTGGNGDSCSSSVNNGRCGFNLQCDPASETCVPVPATTAGSLCYVDPSQCSSSLYCGDQSRCHPRLPFDSDCSAYPDSCQAGYFCTAEDRTCQPQGSYEYASCSSTYANQCVSPLYCSGSTAAPGYTQKCLSKVAVGRSCVRDPVDGCVAGAYCTLNGQSVCAAEVTTVGGSCAFDPVGACGFDSQGDQLYCVSSTQQCQKRATAVGDSCAFDTVSGCGVDGNGAVLYCDTSAAGGPVCAEQLNSIGAVCRSNPLSACGVETAQDGTTTPLYCSLPSYTCAARLSLGDSCTSNPAAACIDPLYCSSNTQVCIEKQNSFLGLCNADPYAQCGIDPSAIAQGRPGQLYPDVEVNSKGDQICQCLSSPSRPASTPLLGAFGLGEGQDCSADPKFSCGYSTSGVKLYCALPTSTCQTHVTTVGGSCAYDYLGACGKTAASNGDYVQLYPSIPAGSTGHAACTCVLQADVVVRPSSRARARARARRNLSLCPESHTACPVGKGFECIDTTSNIEQCGGCSGDSDSVDCSALEGVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIZ2</accession>
    <name>A0A2S5BIZ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein mago nashi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIZ2"/>
    <dbReference type="STRING" id="741276.A0A2S5BIZ2"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="17190" checksum="BEA2E10D6B01EDAB" modified="2018-07-18" version="1">MADQFYLRYYSGHVGSYGHEFLEFELTGNRLRFALNSNYRNESMIRREMTLSDAVINEFKRILNESEIVKQDDDKWPKKNVVGKQELEVKLAPYHISFQTAKIGSMVDVNNSDDPEGLQTFYYLVQDLKIFVYSLISLHFKIKPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ20</accession>
    <name>A0A2S5BJ20_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ20"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ20"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="439" mass="46861" checksum="32A46DD9B524B715" modified="2018-07-18" version="1">MSKSTASAARPPHLVAAASAPSASKRTTDAFFRDALLCPDGSCLLATADDRSLSLYALPFGGDEQQPVASTSKLEPAWTHMPSDSVLSSAWYPGASAYDPAMFTFATGVKDHPVHLLDGNDRRVRASYPIIDHTERFVAPHAMTFSPDGSSLYCGFENAVEIFDVSRPGEEGFRMHTTPTRSSRQGQKGIISSLAFSPASTTSGSSLLAAGSFSGSVALYDPAMPKPLANLLFPSQRGGVTKILFNPVSPHLLFVASRHSTHLDVWDLRNTSTRSSGGRLARRAATNQRLGFDIDPSGTWLTAGDEDGKVSIFSAQPLPDQLEAVETFSLGTDPISTALFHPTQPWLITTSGARKFEKRRTSGSRPQRDWLDSDSESDVDADSGREGGAQVATSDAGVTEQQAAAVVANSHERAGALADAPCADTDSLRVWQWSASRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZF5</accession>
    <name>A0A2S5AZF5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_7104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000172">
        <property type="protein sequence ID" value="POY69895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZF5"/>
    <dbReference type="STRING" id="741276.A0A2S5AZF5"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY69895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="621" mass="67814" checksum="BA00C74F7FFE38D3" modified="2018-07-18" version="1">MRIIDCVGMDAARTKWRCASLNEFRGMLGLMQYKSFEEWNSDPEIARTARQLYEDIENLELYPGLMCEEPKPSGDASGLAPGYTISRAILSDAAALVRDTDSSTLFSRFTHEATAGSVTSFHYRDLQPDYENGAFGGQIGKLLLRHFPKAYTYNSVYALFPFTTPEVNKANLTKLGIAHKYDFGAPATSTTWHVIKDYKTAESVFADSNRFSNVYGPALAAMTRKGDFRLLDYLSASTGPKTAKGFEDVIDTAFYPDKWTVSAYKSAAQLAKAQFDRVAAGSRKNAVSLDLIADVIVPVVTSFIATQLGVPIKTKENPLGLWTPARFYEALTEMWSFAYLNFDPALGFKLREKAMKSSEVLLAVMEGRLLQTQGTPFSLHELLVDVKHLFGIDSQGIVMSEDARKTFGRALRATDRPLSEIAGTLTIAAIRLVTAVSDAALVFDFYLKPENKQHLDEICHAARRQAGLMDEATIQRYAEEALRLHPAVAGSARRANQDVTVSGGVTVKAGQLVWIDAMAVNRDESVFAHATQVDTKRNPGLYSMNERMSNLASRKGSSLNTTIATAVLAEVCAYGTPARANGRAGELGAILGADGMCRSYLSPKGPPSAFPSSMKVVVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZR9</accession>
    <name>A0A2S5AZR9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000153">
        <property type="protein sequence ID" value="POY70032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZR9"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="88" mass="9180" checksum="750ACA2E62B5FDAB" modified="2018-07-18" version="1">MDTSSMSASLGPAREDHLPFPDSVVLAVMTTAARAAMAQPQTSEMEATSGVKVDLVLASGLVPTGEAMSIWAITTRERGRTSAVVEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZS0</accession>
    <name>A0A2S5AZS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000153">
        <property type="protein sequence ID" value="POY70030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZS0"/>
    <dbReference type="STRING" id="741276.A0A2S5AZS0"/>
    <dbReference type="OrthoDB" id="2521467at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015534124" evidence="1">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="187" mass="20167" checksum="930C4DF3C7B7D70C" modified="2018-07-18" version="1">MLFENIFLPLALLAAAALGTPVATSTDLSGPTPPQLKWLYTAYALCPADLLNGALTPAGIRKEIPIVGGNFTGPGINGKFRSQGADWGTVDPRTGIFSADTRYNGVTDDGADVYFQTSGPMTPEGTLHLRIRLETGSPKYYYLNNVLAVGVLHILGQDSKNVSTLRIDAFNFENDWPNTTFLNNTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZU7</accession>
    <name>A0A2S5AZU7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000151">
        <property type="protein sequence ID" value="POY70062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZU7"/>
    <dbReference type="STRING" id="741276.A0A2S5AZU7"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="453"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="9">
        <location>
            <begin position="773"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="868" mass="94497" checksum="72820EA296B461F9" modified="2018-07-18" version="1">MAEPSSPRVRPANVETPTGGHAAQDLQRKTSRAHGAPTNRHPDPVQLHSLALEDGPLYRATLVSLERRANSLRAALKKLVRALETSLAALQADAYAQATLDEVLEDLSAGSFTSESEALKGLYARDLRVARMAARGALQRETDRAREISDRTKGAIDRLKGVEERRKAFEADAKRYYDELAKYLARSDPDPVKLAQLDTKQAERADAFRRSRIEYFAFLEGLVDGEERAVAEWLRNWATPPVEHEITVPVLTTEPADLHTSPVAVAQRSQSPTMNDLPAYIVDAVSAPAAALGRIDVPASDDGRSSAPATSIHSSLSRVTTGGETGVSSSGATSPQLEDPKRRRRTSLPHFGFGSPPIQKEARDEKESQEGGARDRLKGFFRSAHQSITAALPSSPSMSTLAASSLLQPPLSPTLLQTAGGSGASSSHAASTGSRENHPVSPRPSVPRSDSSSRRKEGFLYATETSQRHTQSGDGGARYQRFWVVLEDHLTEYDKWTDAMQVHGSPINLRYATARISQQAGERRFAFEVLTPEWRRVYQASSDAECRAWVEAIQARVESLLNGTSSIRHFDSSRLQTATLPPALDDSGFSSAAGATSPKTRLPDFLFRRASAGHSRKMSRDQHKREKRRSHQIPIPTVTIGEEFGDFSLFDKSRRREMLAHSEGDVDGDAAKPALNGLGLPLDSRLIPAATKSSPDLSNLGDPRVPGFRQNQRSASAGHEVSDGASHEGVSEDETELSLHDRAIYDAVRTWVKPGDEAAGPPALNRSDKYSTAKRIREIATQPGNDRCADCGAPAPKWASWNLGITVCIRCSGVHRSLGTHISKVKSIELDDWTEEQVLCMEKIGNVRSNSVYEAALPADAHNALTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B020</accession>
    <name>A0A2S5B020_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B020"/>
    <dbReference type="STRING" id="741276.A0A2S5B020"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="6">
        <location>
            <begin position="369"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="543"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="651"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="711"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="782"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="727"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="860" mass="90373" checksum="E408B0E823DCEECC" modified="2018-07-18" version="1">MLDLQRHSDAPYAQDLLSLDADGVHRLLSDLGYPHYQDQLHGESLRPCVQHGITGDVLVHLDHAALKDVGVHSVGQRLAILKTVYDLKVAQNIPIEEGHYVPPSEELSSDFQLQTQQIVGLLGERGQLISTRLSNLDDRIRILEHEVLNLHSVLNSLRDDNFHYARVNPSLKSRPVMRSPTSSTFPHPLSNASTLSRSSSTPSRPRNPPPVNISSSLALPNSSTLPDSPHSPIVDSPRLAGDVHQQQQQQQQQQQQQPHYASPHQHQYAQVVTDSNGQHLHPSEMSINGVSTPTTPTAQMLVPPDSNAAAHGAPISATGSLMPSSARTVASPHEQQPHSATGLSPSSHDRRQREASGGAAGGGAASSSSSSTVDNPYRSFRVTVDDPCYKVLPAALKKYKINDDWRLYALFICYGNTERCLAYDEKPLLLFQKLKESNDNPVFMLRHIKDIKSPIAVASAKHAARRDKRPAGIGGGVERSLMGVNRDGSANPTSAATPPANGLAPNARPTRLHHPPVLLPVGKAGGDDSTDGTDAEDKVAKPTNQGYCIAIYPYLAEREDEFDVAVGDTFVILSKTKGWWVVHRDQASPAPSSSTSSHPEHHPAARKSAWVPAGCLLETAVPPLSLLPAGSDPSAHGNAASVPIPPSLVVSVSTPGVALMDYAPRGSGELDVRKGQALRILKRYNHWSYAIKEDGGRGWLPSWFCGRANKTGSSSSNVAPTAAGDGSTLPASSPATPTVPTTNMGAALSSVSSPSTASAPNSSSSLAPPIMPYNDAHAVGHGAGSIVPGQPGLGKPDLSVAVSPASLRPGLPTAGGGGVAGGGPKSAGPMQDGSLGAAQERSLGGLPSSRSADAALAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B021</accession>
    <name>A0A2S5B021_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B021"/>
    <dbReference type="STRING" id="741276.A0A2S5B021"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="357"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42363" checksum="383939E4C66223D2" modified="2018-07-18" version="1">MAHRMRLPPPLLFPSTTSRPLRLAAQINYDPTNPANPPYVLHSVAHKGGYLFAASDDTVRAFSPTLQPLGQLPVAQRGITSMVKGSGKDSNAVFVTAKDGTVSCWDTRDLTKEAFRLKGKTRAGYLTASQSSDQSCLAVGTELHQYEAMIDIWCATRRPCIGCIHGKLTRGSGEWSLAYRDLRTMQIQHTYTEAHSDDITVVAFHPSPSLPHVLLSGSVDGLVNTYDVRIVDEDDAVQSTAQFGASLASAGWMALPGQEGSSDHKGIFGATTIETVQYWDMEQQEQIVDFGDVRDVALQPFRTEYLIGAHYNEALGGVCLLGGSLEGDVALINAKDPERWYLEQLLSAKTSPKAHGCKGHRDIVRTACVNAETATIVTGGEDGRLCLWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0E2</accession>
    <name>A0A2S5B0E2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0E2"/>
    <dbReference type="STRING" id="741276.A0A2S5B0E2"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="370"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="529" mass="55544" checksum="2E90CEE499AB84D6" modified="2018-07-18" version="1">MASSGVAGIPHQGINNLQSLLKRLEASVTRLEDVALAQAQAGGMQHVVSGADATRQPDHLTAAAATSAPPPTPPKTVEKSSPAVDGFQELIDGPLAKYLGLSTELGGLIADQAQQVADGFQAQRDFVRLASACTKLPTSAPEYQELIAPTQSALLAVIDVKEKNRASKENNQLTVVSEGIPALGWVTLDSKPGPYVGEFKDGSMFWVNRVIKEHKDSNPKQVEWARSFVALLEELRKYIMQHHTTGLTWNPKGADPKTYKSSASPNAAGGAAPPPPPPPPPAAPGAPPPPPPPASSGAATSSGGGSGGDMSSVFAQLNQGEGVTKGLRKVDKSEMTHKNPELRSAGVVPTSASPSVPQKPPKPTAMQKKPAKKELDGNKWNIENFDGDRGIVIENTEINQTVNAFNVKGSVIQVKGKVNAISLVNCPKTSILLESTVSSLSVSNSPSFTVQILGKVPTILLDGNDGGQVYLSKESLDCEIVSSKCSALNISLPVEGEEDGIFEEKAVPEQFKTVVKNGKLVTTVVEHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0K9</accession>
    <name>A0A2S5B0K9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0K9"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="832" mass="88234" checksum="04339A6257146841" modified="2018-07-18" version="1">MADPAFRGFVETTLDALLVLEGCRRGFLPKITRRLQEFEKRALVVSGAVFVFHEEETGIKRWTDGLSWSPSRTLDNFLVYRELDKKGSQGRQSDAGLDDSDPASRPNRSRLVGPLTSKADPVDGFSAAEASRIDNEGPDGSRSRANSSTSTPGILDRARERALVGSLTSSSRFHADGLVKKTISLSGLHLISYYRIEDVTSGRLRTPSSHAELMSLEISPSFLAPSLFRLPPVVEIDADGHVRYKGDADTPLSPRTRASSSPGAQQQSAGPNASRPRSSGSASSRLPLPPPAASNWNQSGPQGPQRRSLPAAVRTDHRYSPYDSGRISQASPTYPPASSSMPPALYEPLPLPRPYAGAPVDPSGMGPSLLPGPPPYRGIEPSPNYAPFTGWQRFPAPAGPGFAPVADSPDPFMPTSTAFYQPRHSVPNLPTPGPAANEPFGYNPGQMGVGSSGAPFPLRQPPRTADGYGDDYRRMYPPTSSAYTRPYGEPSRRPTPIQPWVASGTVCPPYAPDTQSTSGPFATPPTSADPSEPLLPMEDAGPRWTTSQAPYAPPVSAASGQQAPAWDYARYPRRGSQLGPNHLQPLASAGAGSDISPHTPTGSHLQRQQQAALEQLYPYDPAGQGDVKPFAPVHTARNPDHTPEMYGIASGHTVDTHASGLVQPAPQDPYSRDGGDVSSKVGNIASKQHSSYNPEPAHPGSLPASRPSSRFASVSGQGYDSPVNGNGGVPLGYHSGASGNREATANAPSWPTAQHGGVKIEDADSSQVSPGASFKYLPPPPPPQQQQPSSTADEPNYASGQLPPSGHWWPNGAPPWSQSNGSVPTESRYPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B110</accession>
    <name>A0A2S5B110_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B110"/>
    <dbReference type="STRING" id="741276.A0A2S5B110"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="461" mass="49406" checksum="A9CFB8F2DACBDCAA" modified="2018-07-18" version="1">MTGACLQESSRVVSVAHEWETSWLEMAEESSCGSGSPYNGQIGLRVGGIFIILVSAAWAWKRDADCERSGRLRTPGRVGGRNRQLTRTTYGLQCTSAAGTLFPQQRKGRRTLTRPLTVPQQIISRRSRLRLPEWAFNGMKWFGSGIIVATAFIHLLAPAFDALSSDCLSGAWKEYDWAPAIAMAAVFGIFLVELIATRAGASFLKKRGLRHHDPHHARGNDVAHTGHGSHPPALKTTTALACESIATVRSSGQTALGADLEASVSAKDQETAVDGDHAHDHGHAHGHAEDEEDDYLQDSAVAQCIGVAILEFGVIFHSFVIGLTLAVTDNIGPLLAVLTFHQTFEGIGLGSRLSMLRLPRRYNFVPFVAGVIYSCTTPLGIAVGLGIRETYNPDSTAASIVSGVLDATSAGILLWAGLVECLAHDFVFDRQMADASNGQVTYAVTSVFVGAGLMALLGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B115</accession>
    <name>A0A2S5B115_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B115"/>
    <dbReference type="STRING" id="741276.A0A2S5B115"/>
    <dbReference type="OrthoDB" id="2536853at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="591" mass="66061" checksum="139D72D8E96EE0DC" modified="2018-07-18" version="1">MTPPAVTDGTGSDRRLACLGNLPPELKALIVLKAVEVDLEAADDDDDNEAADAHGWVDEDDDRDPVESTHPLGRSTKRKRDPSDVGQPARSHTGDDDDGWRDVDELEEENEGPVGEGYGQYQTDMRDALKPTALAALSLVNREFNELATPYLWEELDFEYRSNESALRCIREIVPKHGKHVKMIDFGQSDARMLDLEVEGGYQSADPFAPVPISYRPIIEAAEQLNGVSGDGVSTEIRYRRTRSLLLAEIIRQCPNITSVDTEMMHKTRPEWADDLEDGDLTDSHVVYMTDHALDAVKRYLGPQLEDLSLLVNDDGVSTEGDLADVLLACPNLLRLELDCLAPSGPRANREKLYGALAGLSKLESLTIDAGEFFNDEFATEVDVQWPLKVLGLTECDELSFPAFFTFVHRFSSTLECLDTDRTPHDNNERDTKAYLHRALQLPKLDTLCLATMHEPAWLLDGFAHCPVREFSLGFCPAIELAHIEQFIDLHAQTLRRIEVQGDAALSEAQVESLEVLCHSKHIECEVLPVESDDEDDDPEDGLSDWEDEDADDRDGWTDEEDDEEDDEGDDEEDDEGDDEEDGHPQLEDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B150</accession>
    <name>A0A2S5B150_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B150"/>
    <dbReference type="STRING" id="741276.A0A2S5B150"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="344" mass="37445" checksum="44BF193D5D9005B3" modified="2018-07-18" version="1">MSLFAATRRVFRPSALASTSRALATAVETPGSTGALADAAQASPLSSATPRSTPLPRSQPPTAHDDFVHVPLTGFYQKPAERMVVPLPASLFNVPSRPSLLHKIITAYRSSLRAGTASTKNRAEVNYSGKKMRPQKGTGRARLGDRGSPMLKGGGRAFGPRAKGPDGWKRKINRKEEQLGLKVSLSDKWRRGNLAIVDKLALDLPKTRLLQEKLGVRGWEDALFVTSLFEEGDSERAAFALAAGNLPSVAVVDNVDDLTVWEILRREKVVLEVDAVDQLIERVDPEGPWVDEMEEEMLLEAEAEAAALVQSEFEALPAAEQEQRLQDMATMLAAEEQVASETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B153</accession>
    <name>A0A2S5B153_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B153"/>
    <dbReference type="STRING" id="741276.A0A2S5B153"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="90"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="563" mass="61075" checksum="E8591E76A3AC3D84" modified="2018-07-18" version="1">MSALSTYSSTVTDSTMEKKVEEGRSHVVAAPASHALFAIPEDGDLDEAAEAAGEVAQTFTEEENAAVRRKLDRRVSSHDLSSLLYMPADARIVSDLASTCYNLRFSVPGQELRVPEPSNAINYASIVGGFPITGAHYTVIVAVFYVGFFIAEIPQTIISQRFPIARYLGINVLLWAACLTLHAASGAFGPFLAFRILLGVFESVVSPIMIALVASFYRKEEQAKRIAAFYCCNGITAIVGGIIAWGVSHIDSRESGREPWRILYYIFGGLAFVVGVVVVLFLPSSPATATFLTPREKVVALERIRIGQSGTISHSFKRAQAMEALRDPKTWLLFALMLIISVPNSAVTSFTSILIKSFGYTSQTALLLNMPCGAVQIITTLSTAWWADRRRARMLPFVATLLPSVVGFALLVAYSGTASQNKANKGPLLAGILLAQTFITGIAFLYSWSSSNVAGSSKRSVTNALMLVAFAGGNAAGSQAFQASTAPTYLPGKIALLTLLAVLFPLALAMYLYTERLNKRKVEEVSRMAEENGWTEEDVKRESDRVAFLDLTDSANPFFRYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B186</accession>
    <name>A0A2S5B186_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B186"/>
    <dbReference type="OrthoDB" id="10691297at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1295" mass="135565" checksum="E0B3D13B727782CB" modified="2018-07-18" version="1">MAPGPSLLPVRPGRTVPSALPRAVPAVVVPVSSPPRPKVAYVGDHSPYAPVPSTSRLSPAQQSPPRSDFDASRLKWADLLAAETGDDLLNEQSGSWLLDQSAFTIAATTPARTKTARKRSPTPLNELYRLDDLTDDDAPTAVSAAADPVATAAVSIDASPRRERVQQGDAQILRAAPEAAPLPPLSPSPPPALPTIDEEPSSLLGPNQDLAGPEPTEASDGECPASPPRARSKSATPALEAVQPNADYARRQYRPSLAPLPTGHGEDGDNTVQMSRSRSTSPAAVPLVAPVPERPVGTASGERVAFLAQNEAPPVGSSILATAASTNLHEPVPTLSSPTIPSAAAEGVTDSGGAVAAPSLPAESTAAPGKRRVPRASLAVTSRAAAAGPTRPAHLLPADHPAHPRPSLLASLSASSAPLAAPAGPAARPKPAAKVKGIPGPDEEARRRAREAKEAREKSARERKDKAERHAAALREEKRREKELEKAVAPETAAAQAKATSATSAESARRTAQREAHHLERPKGDEPRRLHSLDAPVQTVSHGAISSKAPLEPEVAGCAPPAVSLSSTDRPTFAAIPTAPTSTAPTASIAPTASAEPIVLSDRALPLVIIETCDDSQHPNTATHPFDADMTLPDMGAPLDFGSSSTMQSQLVSGTQVSSATTSTPARHLKRKADSDGAPKAGVNDKTAGATAPSKRTRRPSVVGAQSQATSSKLSPAINPRQGVAERPVFESVAPPAGTSETGPMAAPKRRPSRLTVDDDCVERVDGSRPLRDQSIASQPGRARVVRVTLQVPAAPQAPPTHLPALPARMGEPAVSTAEAKKRRRASRVTSPDAQPAVAKPASSPAPPPASVPDERPHHLLKHSRSVPVVSAPAPVIVELPARPRVKPALVIGGITLPASFTFAEPEEEDEVERARRLEEKERREQLAEAVLAEKKRMRESASAWAMRPDEATKRRRIVAASSKHGSDVGDTAAVPLPASAPTRADTDRARNAARPSEHFSPRTAPASIEAPTSSCGVPSANTPDEPLALTREALERNSRKVGPRPDLQRRVSRFLEEISEAEESPEVAVLPAIQDSPTGLAASPAATVAEKSAVVLADPCGPVVKPVAAERAPSPVPEALVGDAAVTNLMQPVSSKEGALAASLRNASVAEDGARPKKISATTSTVLKPATKRPAAPVKTLSEPHPTKKVRRDQPTLATASAARVRPTGQENGASRSRPEGGVAAEIEKQLQARLAWSERQKRREEEAKAFRQRQRDEEANRERAKLAQLRSSLQQARRPAPALKPVARPVSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B200</accession>
    <name>A0A2S5B200_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B200"/>
    <dbReference type="STRING" id="741276.A0A2S5B200"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015417537" description="Peptidase A1 domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="238"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="551" mass="55622" checksum="4C27B092657921FC" modified="2018-07-18" version="1">MKPVNPVVFAALLAALSAVAAPLPDETRGGIAIPLHKRGGDGLAGSASGTVSDGAVFNPAAISATIAQLKAKYAGNAAAHEQNEGTQPLAGVNARLRARSTDPGGDEVHLERRVTRLPYLSLVSLASASAASVASVASVASAASAASAAAASGLATNTQVVRLPYASLVSLASASRASASRAAASAASATAPSSTPVASTPSSTSSISISPASSTSSAVQATPTTGSESLTSYGDSYWAGFVTVGTPPQSFLIDFDTGSADFWVPSSSCTNCGSTKREYDPSKSTTSYAEPGQSFAITYGDGSSSSGPLYLDTVSVGGVAAVNQTVGAATTISSQFSNSAQDGLMGLAFQSLARTRAPGYFQTLVDEGRVSSAMFSFRLATRNYGPSELYLGGMNSNLYIAGSTTWAPLLARSYWVVAGQAAVNGAVVSSVGTFNAVIDTGTTIIVLPPSAAQTFWAAVPGSAPYGGGGGYYTYPCNSNLVVSFSFGDSTKQWPVTYFNLGQTAFGSSTCVGSIVGQNVGLNAWIIGDNFLKGIYSTFDVAGGRVGFSQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B228</accession>
    <name>A0A2S5B228_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B228"/>
    <dbReference type="STRING" id="741276.A0A2S5B228"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015678204" description="J domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="274"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="341" mass="37127" checksum="92DC9F7EC91466AC" modified="2018-07-18" version="1">MRVLRLLAGAAVFALAAAPALAWTNEDHEIFDIVSALESAEGKGTTFYSFLNTTKQADDKAIAKAYRKRSLELHPDKNPNDKKIQDRFARLGVIANILKDAEKRKRYDHFYDNGVPKWRGTGYYYSRYRPGLGAVLAGLTVFSCFVHYIFLYLTFRVAKLRIGQFRIQALEAAWGPTKKPLAGRKRLKVKTAEQGDPLGMPGVNDGRPIAAGATIEMVVEGEKVYIVENRKENLLTEDLAVKPSVKDTWLPKLVMERLGYLPASKTKAKRAKRAVTSTTDDSASSSGGEGEASATGSGTATPTRAAKVKGPGKGVEGQGKIGGRRRKTVPARPASSGKDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B250</accession>
    <name>A0A2S5B250_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bestrophin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B250"/>
    <dbReference type="STRING" id="741276.A0A2S5B250"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35384" checksum="34A99105B82A1AFB" modified="2018-07-18" version="1">MSTFSSAGSTVLEKNASGLGLSTSSDETKSDVHVCSGEHKYKTEEIHLAPGYCPPERSVYDYAPVLLVFRPLLRRVWHEKKQNRQAVSSNIPLEIQLYLSSYLATCIKRATIPATVVSPAFAALNQLADSLATMERVLTTPLPFSYSVHLRATAFFYLLLLPFQVYSSLGWLTIPAQFIAASVFWGFLELSRQVEMPFGYDDSDLDLDKYCSLIASELQAIAAHSPPSPDTFAFAATNTPFAPFDKRSAPEILVDFSQTHGGTQQSAVRGVPGMRRFLARHYHELEERTKRCAMPDRGKGRKSAWAAAHEKQTVKVCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2B2</accession>
    <name>A0A2S5B2B2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6097</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2B2"/>
    <dbReference type="STRING" id="741276.A0A2S5B2B2"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="169" mass="18752" checksum="65DE8704EA4A38FB" modified="2018-07-18" version="1">MSLRLLSLRPVARAFSTTARASTIVPVRAVETEGTSRVPAERPEGGAITPAGVVSGAPDEMHRRPVRIYRPAPPATSSAKGSSHNWRIDWDILQGAGRWENPLMGWASSADYVQGTSLTFTTAEEAIHFCEKQGYPYIVQQPNVQKFVPKTYANNYTYTSRKLRIHHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2D8</accession>
    <name>A0A2S5B2D8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop14-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2D8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2D8"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1056"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1069" mass="116802" checksum="7B8196FBE6B2B5F7" modified="2018-07-18" version="1">MGGSQLTQLRSKLKESGLSRQSNPKDAKKRARQRKDLSSASLKHRNSKLDAIHDQFNLFDVRDEKKKFSVVTRSGKEEGGAKGMPGKARAAGIESRKKTLLPMLDARTHASTFVDHRFGESASYLTPEEKALERFTAERQSRLGGASANANKRMRFNLEDDTDAGGEISLTHGGRKLGFGDEDQLEDGGGWGGLGVSEGANRQPLVNPRKMGAVAEPEEEDLIVREMLQDDGRKKSHNEIMQEVMAKSKFHKAERQKMKSADDDTRLELDNELKDLRKLLVGGPAGSSKPSSGSAGGPSAVGEDDEEEDEDEEGEEDASDAEDSESASDEGSDGEGSTYELNDEELEAALAASSSKSGVDRDLLRKLIGSAADERSPSPEPTTSAAPAERPPPAEVEAESKDPYDLYVKQLALEPRAHATDRLKTPLELAQEAAEQLKKQEERRLKRARGEADDSDDEEAGADGKKKRERKRAPQGDDLDDDYLQEQYGSDVEEAPAADGPEGLGAGLEDSEQIVLEGESEDEEASEDEDASGDESGEDDGEAEDDDDEMDVGDLDAEDSEVDAAEQGEQEALVAPSGASFDAAGELPYTFPCPSSHAEFAKLLSSSGIKEEDTITVVKRIRTLYHPGLAEGNKEKMQVFANVLLDHVIYLAASSSPTAFETINSILPPLLTLSHSYPLTCAPHYVKKIGLMHKNLLRGLIKGPLDPSAKTWPGAAELTLLRLVGMVWSTSDLSHPVAAPALLLISEYLSQCRIRSLADIASGLFLCSLVAQYEEQSHRIVPEALNFLTNVIALLLPTSPSIVTSFPGSFPTPDLGQEHVKPLKLRSNSSATAHLELTAPVDLLSALKAKSKSSSAEADQIKLDLIASALKLSEAHRAMYADSEALIELFSPLVRVLKAVKRSKLPSSLAVSLFMIGETSDETEIVSIAQTEVARVHEALARALTFAGQSRRPLYLQHHKPIPLATYLPKFDEGFNPNRRFDPDSERAEASKLRALYRKEKKGAVRELRNDNRFLAVEEAKRKQEENQQYEKKISKIVSSLQDERAEEKAFERTKEKGKRRDKARAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B300</accession>
    <name>A0A2S5B300_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B300"/>
    <dbReference type="STRING" id="741276.A0A2S5B300"/>
    <dbReference type="OrthoDB" id="2536675at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="350" mass="37144" checksum="39C12C2401037F88" modified="2018-07-18" version="1">MTGQPATIVARWPSANPLSAIPLLGRALTVSRPGTSLGRRAVQIKPYRLPAGGREVPQGRNMYVVREHDGNADRVAVFVEDPNAPTRPPGKGKSTAHKQDDDDDDDDILFVDQDAREREKGHPRWTYCSIVQPPLSTSGDGDSAPAAAALFDTFIQRALFAPPQPGGGQSTSNSREGAAAAGRSSTPQQQQQQQQQAGSGPHQHWQPRAQVISIEGFVFALASSAGATAGATGSGATAPDWIIRVGSVGLKGGAASGVTKGCILEATYVPVPYLPTGSTFARDFVLSLFPDAAVRNGEIELVEPSETDFAEAGMLDPPDADKGEEVGEWEWQGKHTLFAYVHQFKKEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B323</accession>
    <name>A0A2S5B323_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B323"/>
    <dbReference type="STRING" id="741276.A0A2S5B323"/>
    <dbReference type="OrthoDB" id="2210at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="5771" checksum="3CE9B3294B3D87AD" modified="2018-07-18" version="1">MLSCWASSGDLASSTACRDAAARLQECMRKPQAKGKPRVSSINYLLARTNAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3D1</accession>
    <name>A0A2S5B3D1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Diamine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.57" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3D1"/>
    <dbReference type="STRING" id="741276.A0A2S5B3D1"/>
    <dbReference type="OrthoDB" id="2535684at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004145">
        <property type="term" value="F:diamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="233" mass="25895" checksum="28EE23724AE6265B" modified="2018-07-18" version="1">MAAIDDPYERDSDNDSEESLDPEPEYVHTKVRAATDTVNRTFTLMYACPSPATGRDGREGTLRLKGEASDFGATLFHRNGKVKAEVDAVVAYLEEIRVKKEYRSQGIGTWALQQLLVDNEYHLEGARFTYGLPSALWSNFPHLDQRECKDTPAEVTAADVGLRRVGTSAYLCCAHSSNHLSHAIPADQDAEHVKIADELGDTGDETLRRALQILQRQNIPFPERATVYACSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3F9</accession>
    <name>A0A2S5B3F9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3F9"/>
    <dbReference type="STRING" id="741276.A0A2S5B3F9"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="71"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="179" mass="19577" checksum="2A6186788422FF64" modified="2018-07-18" version="1">MAAFLSVTEFLDDSTKLPCKVLFDVPNTGHLEGGADKDLKTNATLELPYWLATKASEQDIVDLTLPRAYAPQVRHALRASPTALNLRNIGGGGGAFYSGGMRLLRLVEDTELSAILETSFKTRLVEIMDQSQHSLADHGGEGAAYEFAQGLDSWEKELFTVGETSAKQIKSWMDTKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3H7</accession>
    <name>A0A2S5B3H7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3H7"/>
    <dbReference type="OrthoDB" id="2528292at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36744" checksum="6CBE70DBE4FBEAD2" modified="2018-07-18" version="1">MSASIDPVCEDLCFGILDQLPSRSLIQLRSTSRVFASLVDEILRRRFLAIIATGTHELVVESCPPYATRAADQFPLVFSHFASGVGNACSGDIALMRTKGGEEDNAHFLPLDDGEVFANNHLAIHLRQCGVTTLEDDFELPTTRLARPLQPRTFDFLNSIRIATSLDRFFRSWFIDPVCEPDWSTAWSPSAPSTPTSSPESTPWTSREGSPSPFFEAAGSFEKRPTRSRRIRTNQSATSALSGAHIECVQVPASAADYDHPDSFFYSPIAGTSPPGSRFHSSPTSTPRVYEYYFKSIEMDVGKVVVAAEENFPTTIYPKPGRAAASSAPYIFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3L6</accession>
    <name>A0A2S5B3L6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3L6"/>
    <dbReference type="STRING" id="741276.A0A2S5B3L6"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="211" mass="22888" checksum="1615F86C3387DF2E" modified="2018-07-18" version="1">MLRSSVNVLARQARVPAPSSALACSACRSFASTSRAAAPTPSSAQQQPQQPPQQDQAKSAKSTTTELLNLFDSLDQIAPAEAVDPASQVSVLRHLSREQVISPQQLSPRHLLQPYPSRPDFSQAFPLGPPTAYAHTHDPFIRYGLDPLEDAQLNPSLLSEFVTSMGKIKPRGKTGLQRKTQRKVGKAIRRARSMGIMPTFGISVPGQGREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3Z4</accession>
    <name>A0A2S5B3Z4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3Z4"/>
    <dbReference type="STRING" id="741276.A0A2S5B3Z4"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="369" mass="40985" checksum="6CE67676D1DE9556" modified="2018-07-18" version="1" fragment="single">VFGYDYNTASTLESDVPEQAIRLCFRYGITTLDTSPYYTTSEKVLGGVFDKVRDEFPRESYQIITKIGRYGRTKADFDYSAKRTRESVENSCKLMKTDYLDGVYAHDVEFVSEQIGGAGQEGFTVDQDGKIKQEDMVRWGLEDKDAGTIRGPGDEKILEAFGELFKLKKEGKIRAIGFSGYPLPTLLRIARLIKHHLEPIDIMQSYCHHTLQNLTLREFYPLFVEAGVKQILVASPLSMGVLRGAPPPEWHPISPACRSATAEAVELCKAKGKKLADVALGYGFTSVKPREAKAGRDTPCVVGLSTPEEVHEAMMVYHSIYGQGGASREGRLPGEGLGEQFKDQLELEKAVVDTFKKHGGLNWTWAVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B408</accession>
    <name>A0A2S5B408_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000083">
        <property type="protein sequence ID" value="POY71518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B408"/>
    <dbReference type="STRING" id="741276.A0A2S5B408"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="389" mass="43126" checksum="ED8718019166F11D" modified="2018-07-18" version="1">MASNLFAPSPEPKTPLGRHRVLGPHCGLRVSPLQLGAMSIGSGWSDMLGSMDKEQSFKLLDAFLEAGGSTIDSANAYQNDESEEWIGEWMKDRGVRDRMVIATKYTTNYKMHAIGKNEAVNFGGNHKKSLHLSVRDSLKKLQTDYIDILYVHWWDWTTSIKEVMDSLHMLVEQGKVLYLGVSDTPAWVVAAANQYAMDHGKSPFVIYQGRWNVMLRDFERDIIPMCRQFGLALAPWDAIASGRLLSKKALEARKQSGEAMRRGGGEQSDLERKYSEVLEEIGKEHDCDSVTAIALACECAQGNTPNVFPLIGGRKVEHLHDNIKSLTIKLTAEQIQKIDAVQEFEHGFPHNFCGTDPTMVPNEGLPKNSLLGSSGTLDILPGPKPFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4J3</accession>
    <name>A0A2S5B4J3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4J3"/>
    <dbReference type="STRING" id="741276.A0A2S5B4J3"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015404402" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="702"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1214" mass="120783" checksum="CC19231AB3D839CA" modified="2018-07-18" version="1">MRTATLQQVVAYLVLCAHLSLAQDAASPETNDASRLPAAVQRLRRLGFAAASPPQASLAPPSPQRRAREFGQAQELERRQSIADQIAAGDVGLPMNTTSTSTSTSTEATTTSTTSTSTTSAPVTSTTRSSARPVWSDVQSSAIKRLCIRVRQFAFVLDEHEQRGGVFEHVGVRLFNKLVFAVDELAYRRNDQRVVLVHSFFFLLHVELVDRREHLHERTRANHFVFDGTSQHRAAYDVLVQRVDVELVHIGPCYGREITTSAPPSTPSTAAATSSGPYGGILSQLGGLVGGGSPSSSTTTPVVTTTPAAQATTSTSPAASEAPLPSSSSSSSSSSSSVNAPATSATTGDAAVTASAVGGSEPQVVTASSSSPITTESAATPPVAATSVTAPVSAESASSSPASPAQTFSSSSSSVPQSPSQQQQPATATTVPSSSSAASNTASGASTAADNVPVSSPVSSSAGPTGQPTMPPASSVSQVASSQDPFEQISSVLANATAAIPIPLPISSTVVDTTATATSTVLPPPLPPAASGNSTEIPAPIPIATSGSATVSDVPAASTVTSVRLPTGSPPPLSSGSIASSIATETDAGSASASAPLSSGSGAISSGPIATPGPQVSGSGSATVSPSGSGSASSALPTGSNATDSGAIPSTGSSMVSGVTSSTVAVPTPSGNSTATSGVQAGSDSAALTATITSVGSSALPTSSSAAGNGTASGDTGSASSSGSAASSASSASSTSSDPYAWVPTSTLMVNKGSQTATSSASSSGSSITSAPASSSPSQGVSTSMVSGTPSVTITSQAAFPTDLPARIVPDDETLNTASSSDSSASSTANVQMAAASVPMTTISILLNDAMPWEWVVDNSDASGQIFYGVPIVITNALNISLSSVKTIALQAYQTTNSSGASQILTVYLGSIPSTYVDALSAMLQSPTSPIYKQTGLPGQLAETFIPSFSVKSFASDKSASSGSMSDSTDGTSSSSSSSGGLDKSTKIIIAVVVTGGVILIAIAGYLAFRATRSGAIKLSASPRVTQRDFARGGAGGEMSQSGGGLRNFYLGGSPSGGSGHSPYGTWRSGHSGRRDSISTTSTTSTASSGYGAGAHSGSYGSRSGHGSRSDDRRSSWWRFSDHSSLNGGHGSRSSGGGFGGPGQVGLALGGGDTYREGPRRVHIMRGPDGAVAPDMIGRRVEAGSECSDSCEWVLTPLPSFVHRPVAQSNSLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4S9</accession>
    <name>A0A2S5B4S9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5154</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4S9"/>
    <dbReference type="STRING" id="741276.A0A2S5B4S9"/>
    <dbReference type="OrthoDB" id="2537563at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="144" mass="15477" checksum="59B144B415642333" modified="2018-07-18" version="1">MAPKSTTAEKKPASTAGKAPASKAPAGKAPAKKAVKKAPAGGDDKKRKRKVRKETYSSYIYKVLKQVHPDTGISNKAMLILNSFVNDIFERIASEASKLASYNKKSTISSREIQTSVRLILPGELSKHAISEGTKAVTKFSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B556</accession>
    <name>A0A2S5B556_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000070">
        <property type="protein sequence ID" value="POY71910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B556"/>
    <dbReference type="STRING" id="741276.A0A2S5B556"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="518"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="889" mass="94763" checksum="AD22004C6571E3BB" modified="2018-07-18" version="1">MSPNPYAAPLQHHPHPGYAIAGGSDASSIMIHDESTSASPPYDDEYGDGGDGNGSSRSRSTKKPTKGIGRGRETQSKVYAERQGDGVQPQCGVCIATAIRSGHDPSLVVCDFPTEEERRKPVGGGKVYALEAKIQALERKLADAERRAAGGYVPSPRATPVPSTQGMPQIPLRLDDGQVRASPQPRPQTAASLTETKPMIGPERTPRSRHASVGGQPYLPSGEPLRPLYLAHLETGVGPPSAAASTSSAGASTSYAGFALASATKSNVASPFTHHPPYLAEVPGSASTGPVSAAPSFAFPQAHLEPPSPSGQTNGYSGKGILSGHPAFGASPTYALMGPVSHPISTGPSEPAPFSDPPPLGSPAIQMSGAAPPHRMGPSATTGAPVAATVPSGPRLPSYSTLSRLVNVFFDYPHEAIDLINRRRFMAAFECPPDHPEYPAECLLHAMVATATDLAGLDAWEGEERYWNEGQSPAVFHADLAEYLLPLGFRTERNLLQVAQAAVLFACLNLYHGRFSRAYIDTSIAVRICTSLGLNHNVFLPNHLPLSSFLAHRTALPPPADEEEARERSVTWWFAYTVETFSAAATGWACCIDERDITTLVPAAGPVGDDPIAREALYLHSPSFFITNPPHLVRLVQINLKVTVLLNRVCTFVSRTTALANATPDRSALKPSEFPKIRSSPAFTKLEAALENFGRKAPAQLVALLEPEAFLCPSLVATSVILLHERFCTSEHNDPSMIKCLEAANSILQNMQVLNNASFHPRQIPPFLSFCWTVAARTYLRQLAIRQLKGMPPVHLGDASLGNGHNGGTPTLEDEVRHLTQIVTSIIARLEHFRTPVGPLMAASLVSLLDRPDICLPEADRAQVDRSGQTAIANLTSVMSSVAPAAVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5L7</accession>
    <name>A0A2S5B5L7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_4916</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5L7"/>
    <dbReference type="STRING" id="741276.A0A2S5B5L7"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="623"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY72046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="771" mass="83473" checksum="96E1606FC8AFCAEA" modified="2018-07-18" version="1">MVAGPHRARLSPPDSQRGALWESRVPDLASVIQQARTLHPPRQASSDSDEEPVLDPEKADCRREARCGAGMSAADFFIPSLPGQPADATVTMYGGHIASAPPKNGSPDTESDAHLYFYLVRNRHIADTERTLLWFNGGPGCSSFDGGLMEIGPFRLAPHGDGKLVELEGAWNEYANVIFIDQPVGTGYSYMSTNEYLHDLPEAADHVVEFLSKFYKIFPEFANHDTYIAGESYAGQYIPYIARAILETTRIPTRLKGIMIGNGWIDPLNQYPAYLDFALQAGVIKEGSEAEKKVRKAHDTCVTRMKMDGGIGGKRLPVHIGYCELILAGITDSTIQSVNGQNMCVNNYDVRLTDTHPACGMNWPPDVHDLAPYLSREDVKTAFHATRHEGPWTECNGQVGANFYTPNSLPSVTLLPDLLTKIQVMMFAGAEDLICNHVGIERMIENLHWNGARGWENATEEEWVVNGRTAGTWTTSRNMTYVKILEASHMVPYDQPLAAHDMFLRFVGASLLSAAGPAAQVPSRIGNEIPAVLGSTRPDGSSLNSTLADGSSTLGSAGQMDDSVLSGSKGDSSLSDGSWWSPLSGGAVEGLAHASSAIVLVLLMGAALGGFLWYRRRTGLSGRRRAGAGKGWASLTPRGKQHARAQNLGRGGGQGMGGVEDDGGLDASTTEDERDRRLRAGTSGGGGGGEEQDSHELDELMRSSHAQSRQRLFDVEDEEALDAGKRRQKERRDLDEEAKVFGLGDDDEGGDASGGETDTIADKEGRRNWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5P3</accession>
    <name>A0A2S5B5P3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5P3"/>
    <dbReference type="STRING" id="741276.A0A2S5B5P3"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10540">
        <property type="entry name" value="SET_SpSet7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="141"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="555"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="78060" checksum="19C74AC95BA238D6" modified="2018-07-18" version="1">MNQTIETLLGCRTDAPGSIQHSSTRSPVLLAEPPHPPESTANAKSPSRASVALSGAGASASAGGADLAGEQVGTVEQELPSTRDRPSSPTDREWAPPTAEALSQRELAYSYPPPPAVNGTGAGETDTALPYPPATPHLTRAPIEIATRDPSVGRGVFATSDIPAGQTVEISPVLVLGEEEYTGRRKGEDCTDGRLRGVEASQLRGYVFTWGRDGSMAVALGIGSLFNHSASPNVTYSLDYAQYTISYRTAKPVRKGEELCIFYGHSVRFSGSAATAAIERDILEDESQSVNDEWGGLGRLGPFETTSDTSSDAGGRRDSSDPSRTARQARVAALKAMSPEELAERDNEIIAPTDAEFRWKKVTELIDPEDAQLTLTTCYAIDVPARISAAVFQFVRKHTGRKFNELAHLKRVRPVYEPLSTTSTPKVETVDLPTQPGGDPPASPTGSSSSSSLKQIRQPRTGPDALQSVLLFPVSSAPEDLAELLAASPVGQALLPESVPLLYTVEVPAEAAVTDLQASEWGKVWPVQIMHIREGAKATKRKKGWEKAKLEWIESQARKVWERALDAGRRGEHPVACRVTDSWCTGFHTSLHPPVTLVTAHDTRVSTGNVLTHAASNAIDAVAYLDCQGGRPDPALLSPETAVPPYLLTGLSVFLSHEPCLLCAMSLLHSRVKNLFYIKRAPGAGGCGSLYSVHEDRGLNHRFEVYEWDGGDFEGIGTGLQCELPLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6G9</accession>
    <name>A0A2S5B6G9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleotide diphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6G9"/>
    <dbReference type="STRING" id="741276.A0A2S5B6G9"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="70159" checksum="80C219BBF95AD6E9" modified="2018-07-18" version="1">MSSAGLPRYAPVATSSSSAEVHKFGTTPTDEPTSEDLELDLRVYGPDDLAEETDADGGEGTRGLLSGKEKGAEADDADEAGPGTTPLRNDRSRRRWVSWRTLFFSSLFVAVVLLVAALFHPSSPYAEYGSSLLSSSTAKDAYYGGSDLPVGVYDADHAAVAKNPLPTDAVFGDIPFAKVGESKDKSGKVPNWAGGDWGEAEAEKNLVAGDGKRWNGTHWFDPTVLVISLDGVRTDYLNEGLTPHLLDISRRGVRAEYLRPAFPTLTFPNHWTLLTGLYPSSHGIVANDFYDPAISKEFVYTEPGQSWDAEWWGGEPIWATAVKNSLRSAVLMWPGPPMLQDGTKPSLWYPFVNHFNYHKKVDRVEKWLDMSYSQRPHLMTVYAPEVDQAGHKSGPHSHNVDKTLRAMDKFVKDVFDAIDRRNLTEIVDVIVVSDHGMAATSDDRLIFLDDILGAEGFASITHNEGWPSAGLRFAQGTDEAAMLDRLQEAASKPGSGFACYTPETMPERWHFTGHERIAPIYCVPEVGWAITNRDEFEVKMRGTYTIKGNHGYDNADESMHAIFVAHGPFAESIKQKELRRRDAIAADPHTLVIPGFDNVELYDLLASLLRIPVEGRAQTNGTSGFWDEWLDFDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6J3</accession>
    <name>A0A2S5B6J3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="3">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6J3"/>
    <dbReference type="STRING" id="741276.A0A2S5B6J3"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="6">
        <location>
            <begin position="76"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="303" mass="33191" checksum="2C492711AD627977" modified="2018-07-18" version="1">MFATAICRSACSASQAAAKAAASARRPVVWSYLPSQLPYERGLLLQESIVQARLSAKAALLDPPTDADKRAALERVAETDILLLLQHTPVFTAGRREKNPEQLEQEGARLRALGADYVHAMRGGQTTYHGPGQLVGYSLMDLGAAQLSTRCYVDHLERFLENFAKSLSVPVYPLEHTGVFTSPTTKIGSIGIHIRRRISLHGFSFNVEEQTKAWFDQIVACGLADVTSTNVEAEMRKLGKLGQSEPLRVLDTVPKAVELFGQMYGREMARLAPEDEYVEARTLITDGVEGRLPSLEKVPSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6P9</accession>
    <name>A0A2S5B6P9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6P9"/>
    <dbReference type="STRING" id="741276.A0A2S5B6P9"/>
    <dbReference type="OrthoDB" id="2535785at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1154" mass="125754" checksum="7E2090539AF8A7A5" modified="2018-07-18" version="1">MVWVVEGTLQSPPGVDVETFPEASSHWLRPVRKYRVGRAGGVRAPPKPGSDKLGAPSRPRLYDFRIASLKVSKDGLIDFETGGDKWEPLYKATAPRNLDPYPLVAVVHNSKKCKLLRKDATKPVALEPDSSGLCHVTVKDGDRFEQDQFFFELKWIPIVVCFAAARADQKPALSQFGKTAGVKIDYGEPRSEHTHYVVRKATPNKHLLSAAMRTMHVVSAAWYQDFKLVCTAPDFPPADQLPAHPGERQEDEDPAAYDKRWQKYEREVLALDPDAGADTARWWSHSLLENDWTSCYPLETEEKYFPIPFTEMDDRAKWIRKVGRKTLFQDVLVASFSGKLDNNDWQGRLLSLGGGHFFASSILQTAPLPNSASQLVDAIETYRTDAKVNIDAKMVIIPPDGLFDEAQRELDEQSLQQKDLLLDLQEQTNASIISSTAVELADAIASVSLDPLLNGPPRSPELRPAPPTGAPMSSIGLPDQTLPFPSGGVPGTHPDSVYPTGRSRTAQTETQRSKVDATQAQPGSEAGPSRAAQQPAPMQEQAQPVPKKPTKLVRRARTGHTAVLDLLEDREEDAAARSTAPRYLTQDLGGKSSSHLTSTRVATESPAVDDDDAMQSSAGTSSGKPRQGKLSRRAGQHKSVLQAWLDDDDMAPVGDAETGESGSGTSQGRAARQAKSKEERMREIREEDDRRAKQEAELHERRKQQEEAERKAGGGRRQRALGTAAGPDTGAVASRQKRAKPTGTDESGSDDARADQPAPKRNAKKDGATPITTLNKRPREMSRAPDDSSSGSERAERGGRKKSRGPPAAESPQTKKEAAAQRKAAKEHEAAERERLLQVKTSKRKGAELDKALNDDFNALKIVKPVIKLMPKPEKLRLGWEEEDSDVERDRLIQADQERLEHGGSDNDDEMDPNRWRQATQAMFVIKPLYLEPHARRGGEDRAPVDPQWSGTTNFKRFRPKNAAAGRPARPERVQIQLVLPEAVDFGLGEGYNDRRGLALNRSQQADGDDDDDADTFSFAGAAKGQTKLNFGGGKKAGSGVKKSTAGSSSSKAKAAPSKAKAKSKRIVADSDDESGGDSSNTLDGAGMDIDELDDDNVPLQPAPAARKVGGRAASARPPSRKTAPATIMIDDSDSDSDSGLTFKGFGKKGGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6T7</accession>
    <name>A0A2S5B6T7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B6T7"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="8">
        <location>
            <begin position="694"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="7">
        <location>
            <begin position="1186"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="785"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1480"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1560"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1690"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="809"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1492"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1574"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1733"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1747"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1808"/>
            <end position="1822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1839" mass="201661" checksum="A5F42CD1DDCB98E5" modified="2018-07-18" version="1">MAKDPPTRTPALTDFFPSPKSTAGKRRATASSTSNRPPSPRKRVKPDSPTKRTNDNSTAQQNLGEVTLSDSSDDDHAAASNVKTAAPVRDDSEDLVIVEPPVASTSAHKLEEPPKRDANGKGKQPDKVAPIFAPKQRRPSESSASPEKEGANGIKQERPLFGGDMMDLDEKPDVKPSPTKNIAIFDTAAATASSSGSGAAATAGSSAGNNRPLDTPLFSLQPRDDISFASYARVPFSFFTDALVLISSTKSRLYIQLVLTNLLRTVIEHDPKSLESVIYLCSNRIGPSYEPQTELGIGWQILSKSIKETSGATSQKLKQLANKHGDPGDIAFEASKSVRLLVQPAPLMCHGVYSTLLQMARLKGTGVLNQKTSLAKKLLLSATGEQVRYIVRILASNLRIGAVRLSLLSALARAFVLSRPPGKEPAPERLDEEGGGKYWLSVKERTEMRRVEEEEEQKAAVKAQKKGGGKGKVKADPDAAVDNKTKEDKMKGKMKTKPRAQKSALELAVEDKFKRAEQLVRRVWAKHPNFGHLVEALLEGGLEELEERVGLSVGVPLEPMLGSITRSFDDIYTRLGSRPFVSEAKLDGQRGQIHVWVGDKRPPGVAEDAGKWFLDEKTGRRVWVRMFSRHLEDMSEKYPDIGGTILGIVERAESTENPLRNFVIDCEVVAIDPVTGAFKTFQELSYRSKKDVELGDIKVRVGIFCFDLMFLNDESLLSTPFRGRRQLLHTVFPPLRPTDPRYAKWELIPSCTDTEPEKVRAFFHESLKMKAEGIMVKLLDEAEVEVEAGQQDAEGGEAGQPDDDDGFDYTSSENNTGKSPSPIETKPLDGAAAADGSDATRKKGKSRRKVLPATYEPDKRADSWLKVKKDYLEGEGAISDSLDLVPIAAWWGQGRKAGWWSPFLLAVYDEETGAYTAVTKCLSGFTDAFYKEMREKYSPDPENLLTSHEPWPEVDGGSLRPDIWFKPTEVWEIRGADFTLSPVYPAARSLLGERGCSIRFPRFIRVRDDKGIENATTAEQLARMYHMQGEVPAEQSKPKPAGAEEETTLPQDRPSEGALLRQWQEYFADPMLSLATLRQEAEEGRVHERGLRSLTWRFFFDLLPDPTPIPSTPTSGSGSTLATYRLLLSQSRSSYTQLRERYLRAPDGRWVQDEGDDASTLSRAKQDPVDAPRLAKVEVRGNNPLGLEEENPWKTWFDDLELRKVIRQDVLRTFPEVDYFRSSTAQHRLTDLLFIFCKLTPQIGYRQGMHELLAPILWLVDYDSLALSDRADDSLPRLALSRDYVEHDTWALFSALMKPAKAFYDHTPSVPAHSTSSTGRNTANGSASPASALVQPIVAVANHIHSLLRGIDPELHAAFDRVQVEPQLYAIRWLRLLFSREFPFADTLQLWDGLFARDPSLQLSNHIVLAMLLRVRNALLHAAAEGYGEFVQVLLRYPACDDGRFRTDLLIRQAVYLRENLAPSTAQVLIGQNAHEKAAVGSLPESRPDLPGQSSLDTSRGHSRTPSVPSQQGLGFLETGLVGDLAKGVYGRAEALGINKALRGTFDEIKRSVAEAQAQAEERRRFNAYSQIPARPPWDPQRSPPPPPVVDKDTLASLASMRAASQAMSGAVDLCVTVLEQTLAPQLEVNGLDKPSANTDIAARNAASQMMALTTLRHVRDVLSGSAPTFDPSVMQPLRELSKEGEVAEMEYGRSGSSGVPLRPTATKTSRDRLAPTGPVDGLGAGFPRLEVASPPASMPAPTTNPGSSSTATQAPATLASNTTTSRLKAGERPLSSGLPPSGAKAREAFPPSPVSTSPPSADTKGDVYPPVRRPGAAPVPVTRSPSSERRPFDPLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B701</accession>
    <name>A0A2S5B701_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4375</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B701"/>
    <dbReference type="STRING" id="741276.A0A2S5B701"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF648">
        <property type="entry name" value="ABC-TYPE TRANSPORTER ATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="344"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="663"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="914"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="973"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="915"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="992"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110093" checksum="47B7C4DBD60665D9" modified="2018-07-18" version="1">MSTSDLAGLYGALSSLRVALPCILVGILVLRWFGKAFVGVMGRIQSAGWTLDDDEYAPPERAATTKADKSKKSGNGGANGEAALESDLEEDDEGEDDEVTPVVVKQKTVRRTLVLTLAGLLAVTYFAEGVAQVVTTVVTSHYTPSDALYANVAIYTAGGLGAFAMLGTGLAYEAKWTKQAKLLVQAAEPWPKQYPRLVTFVAFVGEISILGVFARILALDSTVRPKETVLPIVTICVVAFRILVLLVLLASQFPIFYRSNYVSPSEAPTETTPLLLGNGGTSTRLDPSLSGPTMPPSVLRGSRLPSNRPPDPKSLSILTLFSRVKLLFPYLWPAKSIVLQILALICFGLMLFRRYVNVLQPILFGRVITSLANGQPPFVPIILYVTFSLLQDSNTMLYQYLWLPIEQYSEREMALMSFDILLNLSLSYHTRRRTGELLRILSRSEAINDASLFFELLLFSFVPILIDLPVAFVVLWVRYGITIVGVVTVVAIVYVITSVTLAESRTKLYRALRDESQFMHQLKSDVLFNYETTKIFVSENFEMKRLRDAMWKYQRGYFNVFNSWQSLSLLQNSISAFGLLVCSFILSRRVIDGEMDVGNYVAFVSYLNQLYSPLNQISSLYRRVMNNAVDTEQLIELLNEEKEISDRPNPVELKIDPSSGAEIEFKDVEFSYDKKVPVLKGVSFKVGRGQSVALVGPSGGGKSTITKLIYRFYDVANGSISINGHDIRDLTQRSLRASIGLVPQESVLFNSSARMNIAYGGINRLDIDGRGSERITMDEVIEAAKAAAIHDKIMSFPDKYETIVGERGQRLSGGEKQRVSIARTILKDPPILVLDEATSALDTFNERLIQNRLRELLQGRTSIIIAHRLSTIVDCDVIHVLKDGLIVESGSHNELITLGGVYAELWQKQIEGQESSVPASKAPSAAATPSATRSASPEPPATPAPPVSALSSSLSGTAAPFVPAAVLATDEATEPAVADLQSRPNGQTKKGTSGKKRGGGKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B706</accession>
    <name>A0A2S5B706_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B706"/>
    <dbReference type="STRING" id="741276.A0A2S5B706"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015440975" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="258"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="318" mass="32064" checksum="44A66584FF090184" modified="2018-07-18" version="1">MRTTISLIAIASLSSSAFASYGRYPCNLLNGDGTLSADRNQCLDGVLRNPGAGDKGALPNPTSPECVQDTINGDFACGIAGATCTSDANCDVGTCVGGVCSGAPGTFCGADDSLCLGYVYCTDFDAAATASQTCGGLGSYCQDFGLLMNLMDPADVVALSSQTCAQSTQGEVYCGFNSAVCSLRVTTIGGDCSADPDFACGTTADGQSLFCTGNGGTTCALAASPSGRARARRNTRFFKRNACLASHTACAIDGNAGFECIDTRTNLEQCGACATEGGKDCTAIPGVDAVGCVGGSCEIWSCQDGYMYDAASDSCVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B768</accession>
    <name>A0A2S5B768_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B768"/>
    <dbReference type="STRING" id="741276.A0A2S5B768"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="241" mass="26562" checksum="8C502995ABF19CBB" modified="2018-07-18" version="1">MPSRPTFGSSGLLRALRFPLVRRPTSLASRPSRLASTAPTAPNPSRLTPYIAHLRAQYPHAEPRSLVAAFVVLHELTALVPLAILFGAFHYLGAGAVMVAWVVDETTATTSAAGGGETTSTWKNTVRTWLVEAENKAERVGRRYGLFGWTKESREEREERKLQEAERPVEPLTKERLLVSGDVANAAAAYLAVKALLPLRILISLRLSPFVANRVIGRYKIWRARRLPPKRAGPDDAARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7S6</accession>
    <name>A0A2S5B7S6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7S6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7S6"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF203">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015653315" description="CMP/dCMP-type deaminase domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="269" mass="29458" checksum="37AD418EB807E3D2" modified="2018-07-18" version="1">MQTIAQLALLGAACVQAVLGSHYPGLGLHNDDQSGLSLNGVPATTRTKWMRVANDHFPFGVAVVNTTSDELVCVAANKVGVTGNPSMHGEISGLHRCTQVLTERGLSPQEILAAWHDLTMYTTGEPCAMCASALRWAGMGEVVWATSIETIIKNGRNQIYLPSSMIVAASYSMPHQTHWFGSILANETDPHFFHQFNESAPCPGMCTRQKVAGSRVTMCVPDDEWKSEWKAREGEWEKQLMETKGAIAEEWYGVTGSGRKIRNRGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Z1</accession>
    <name>A0A2S5B7Z1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Z1"/>
    <dbReference type="OrthoDB" id="2527948at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="309" mass="32567" checksum="D3B45E23EBA7A8D3" modified="2018-07-18" version="1">MGGVSYLYDSPNIKWSCPSGTGSYALWSKTTPTGYDITGKLAVGAGCSAEVTFSGTTGQFGGAVGPDGVTYGCSTNDGNDFVWYSLEGEKEWAYATLCLADDMEDKEHKLIIKNSPLLGSSLFITNFAGLSREGGEGKTSLGPAGIKTVPVPTPDAAYTSSIQAKASEGAASLKSSFASVSSVSLVSQLSKSLLADKTTASTSVGSTQSTSNNLATTINTAASTAGSSAVVDSKSFTTTTFVLISATVLAIIVVALIVAMCWNSTPKKDPARKIEESLSAKHREHRRRLYHLVKKRHFRKESQRFRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B886</accession>
    <name>A0A2S5B886_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B886"/>
    <dbReference type="STRING" id="741276.A0A2S5B886"/>
    <dbReference type="OrthoDB" id="2525011at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="263" mass="29897" checksum="81850F9CC5E1DC04" modified="2018-07-18" version="1">MDLIIWGVGYVASNQLERLRQFRSPRIPSWESPPLAIAGLIHTLLDGDTGPVLTEHGLNIVHETWQTRHAALWLRYRALKDAQQKGLIGCWAGMCTPETMSSTKEAVEEARWVTEHLTEALDWCKERKLRKLPFGQMVKARRNVRERSGSDPRPAYTETPPSLLDLPFPIPLAPQSSRLAPIVPRPPTLHVLETLAEEEERLRPPLYTEEADLLIGESTLEGGMWHDPHESRAYEAAVDEDDDVLAMLQQHYPEDYAHHPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8P1</accession>
    <name>A0A2S5B8P1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8P1"/>
    <dbReference type="STRING" id="741276.A0A2S5B8P1"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="158" mass="17533" checksum="DF099B4C074BFD37" modified="2018-07-18" version="1">MSDDDKLAATLADPTVIVPGFDTSRVMALISLVLSDPSTPKKRLFRAVGTVYLFEVENGKGEKAKWYLDVKKRGRVGSLKADGKAPLKPDVTVKISDRDLVGLATGKLQPQKLYAAKRLRVRGDLDRAYLALRVLSQEREKLEKLALENGVISRREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Q0</accession>
    <name>A0A2S5B8Q0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Q0"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Q0"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="110" mass="12248" checksum="13AF531BC870111A" modified="2018-07-18" version="1">MPSIVHIVSLKYKSTTSDAEKHLVGSSFLALQDKCQHPSTGEKYLTVIGGRNNSPEGFEKGFEHAFVVNFASEEDRAYYLDQCPVHGDFKKLAGQYAEDVFVIDFVPGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B929</accession>
    <name>A0A2S5B929_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B929"/>
    <dbReference type="STRING" id="741276.A0A2S5B929"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000012">
        <property type="entry name" value="SGT1 homolog, MIS12 kinetochore complex assembly cochaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="113"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24004" checksum="8DE9F5A539DF4DE3" modified="2018-07-18" version="1">MSKIRHEWYQTEREVVVSVFIRNVKQEDLKVDLQDRALSLTVSLPTGSDVVFDVDPLAHEIDTNASSYRVLRPKIELKLIKKSGGVKWNKLEGEDESLVKMAEPKADEHPSHAYPSSSRKQHNWDAIVKKSAEEDEELAKEFSKNPNSGDKAVNELFQKLYADASDEQRRAMIKSYQESNGTALSMDWKDVSKRKVETTPPDSMIAKKWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B969</accession>
    <name>A0A2S5B969_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B969"/>
    <dbReference type="STRING" id="741276.A0A2S5B969"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF90">
        <property type="entry name" value="CORA METAL ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="979"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1062" mass="115495" checksum="E8400C094DA0E660" modified="2018-07-18" version="1">MPVNSGHRAQSGDGAAEATEMRTVDHAAWTSVTTTGAALPSSMTCDETADGDMGRASLEGWQSPPPLDSEREGPVRRESVQGRPHFIDLPLPDLRLPDPALVVPSSTSGGAAPVARRRSILSSNGSSSKNRRSPSRTLSPTSPKALFGLQRTGTLSPEMPAPVPLRPILQNPLTPSVRPNLPGPLETDTTASIHRERSPSPVFAPREDDEPHPEHGAHHEQRTPHPLYTPAPKRRRRRRRKNGSVASGRSSRSGKSARSRVKRALRKVKRRRRRGSTAGSVASGTASSGSSTTTSSGSSTSSSSSSSSSSGRSNSTWAGWRFWRNSSSGSSSSSDDSGEDTDSEWDPPTPHFKLLTPVLSRPTLHYPAHLFSGALPTPAASTPQPALAPDQASPVFELADSAALAPQLERLSAFWRERQQEDGIAGDLGAGIYNPGEAPLQDMPPEMAVSDGYFPPGALERDAAAAASRADDSPLGGSTPAVTPGVLAGPSTKRGREQARTARLEFRRLGKNKEQRNGPAWWLDIMCPSVADMRDLRKHLPLHPLTIEDILHQETREKLESFPALGYYFIVFRALDESYFKYTTTTAPPSAASSTSTLDEKKDFASQDSADSPEPLLQPRQRGRVDIVEGVGGKEGVEGVGVGAVNMYLVVYGDGILSFHFEPIDKHLETVQGKLQQYGNSRNFSSHWMAYSLMDSVVDAFFPIMNFVDEEANDLDVFSVGPKDSMDQSEVARVGANIAKSGVGMVAGQRVYDETVVGIRVDSPTEDDYEKLDRTALDMSGIKCATVERVRRVTALRALPAIPLSPTFARAFPRSFLTTIEKPFKSKVLVGEDGIELQDLSSSSRQLIPDGLSVSAAAKRTLDTVMLGKTPRERTAMLQRITQMRRMVTGLSRLLGPKTDVVRGLRKRVLEEDAALFRGDFKHDIAVYIGDLQDHIIAMQQSLIFYDASLTHDHPAYLSILRFSLQYTKRDTDIGLIKLYSIGLTVLLLNIITGLFSVNVDRPHNGTRDAPHVRADGSPAPLNWFGIVITLLVVAAFCLGVIVYFIFRSSRNKHQKRGPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B986</accession>
    <name>A0A2S5B986_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A/B superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B986"/>
    <dbReference type="STRING" id="741276.A0A2S5B986"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="143"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="746" mass="80121" checksum="5C411583437F5388" modified="2018-07-18" version="1">MTKPKPTQDGSQVTLPLVRGAPDERVSITLFFQTIAFALVHLFFVLPARLFLEYIVLRPISPVVKELGRPPLAHAIVRQVYACYDKWTPGQIRLMLDRKRSYNRVHSAREFRGWVERVEVNGTAGRWLAPPKSDRKDDDVVIYFVHGGGFIFDSGTNAQVFFLETIKQLKKQHGLNASVFFLDYRLAPEYKYPSQLIETLAGYHYLVNTVGIPEDKIVLGGDSAGANLASAFLLHLARPSPAITVPEELGETPKRPAGALLISPYTNLYGATNSFYANTTFDILSPSLLARAAFAYIGAEFPSEHKLVKHGWNPLYQLFPTQKLLPQPAHRLADVYGWSDVKNIKLFQDPYVNPFVNEDSSWWTEACPGDGKTLVSRKGIAGVEPVKVFHPLKLHDWLLHDYGLPLSHQVKRLGNELDDLKYGLNQTVKFIAHVVGSAPAPQQPRLEGQSSATKADVQPTREGLRSRSNNAVKADYSNDALATAVGGLKAAERQEVTQADYSDDVIISTVVGLRRAEQQNGSATAADASASKASADPILSTADANSSGDSSPETEPETAKPSVSGDVTPTTGGKNKKKKKKANKSKGAKVQPASNAPGENASAGSYAAVASHHDHIAPDAPVVAEGEGAVIHAASEAPARETAGASVPPPTKKPAEQDAPEPSAAVAKPVAAKPAKKPTFELSELPTREPASSKPSEPKSTKPAPSSTVSGAVGSYAAVAAHDEHIAQDAPVVAHGEGDVIHRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9C4</accession>
    <name>A0A2S5B9C4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9C4"/>
    <dbReference type="OrthoDB" id="2530401at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="303" mass="31305" checksum="C791E143E577D46E" modified="2018-07-18" version="1">MAASPNSTIRSSTFTEWSTVLATSGTSLSSTSAYRDRTTTTFTTTVWQLLYYTGDALPPSPASAVSSALATSSALGNLKQVASVYEGMSFSELSTIAGSALLLILIALLMLICTLAQARRAQRLLADDEEESGDEGAVVRSVAERRPLVPEALNGAAAVIVGVARAKAIQNATGTTHGKDGSSTGTATAAWATQTTGGMTQASDDHDTIVVHSDAGVTYGCPRKTDTWQVESLTDSLSAHVASGPGCFMRYSFTGDSIQVYGASGLQAGVFGCSEASTAATAPPHGSQQQAGSLRRGVDRKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9L5</accession>
    <name>A0A2S5B9L5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9L5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="105" mass="11604" checksum="3002B6F77C19895D" modified="2018-07-18" version="1">MALLDSRKDPRCHLCSRLKPVPHSYTGESDSAGVPSRRDDPSARVRRTLRQVGHRPGLSPTEPGAARIRRETSSREQPDNEIPSKDLEGDHSHSREGAGNQGRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA13</accession>
    <name>A0A2S5BA13_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA13"/>
    <dbReference type="STRING" id="741276.A0A2S5BA13"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="241"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="437"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="524" mass="57738" checksum="21134C8EA2B19D0E" modified="2018-07-18" version="1">MTARKPSLFSLPSGSVSDDSPPSRSRSLDRTAAHPPPAQSAKSNSRSPHRRPAQPHHSSSSHGFGTGRHFLVSEPDSIGSPPCHHHLVSLDEEAALEGDGSTSASERDSLLRHGHARGTDSPKRRLTFPSNGYGATHDGDGATLKRSESILRVAGLIDDRSGEYEQFRKSDAELAKMSKKVRKFYQRQNETLDSFLEVDEILENARAKAMTGELIPSVSAKQADSEEEARASIRWAINLNTVVNIVLLGAKIAIVLVSRSMSLIASTVDSAMDFLSTLIVLGTSRFIEHRDWKSNYIYPTGKQRMEPLGVLVFSVFMIASFLQVLIESISRMLDPNLEAPRIPYTVLGVMCATIVIKSGVWLSCRAIKSASVEALQQDAENDIVFNFFSILFPYVGQLVKFRYLDPIGGALLSLYIIIEWTQTLLDNVRKLTGRRAPPQEHQRIAYLLTRFSSRVVAVQHLSLYHAGEGLVCEVDMVLPPDTSLPVAHNLGEAAQYAIEQLSGIERAFVHIDITVNPLSGHLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA64</accession>
    <name>A0A2S5BA64_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA64"/>
    <dbReference type="STRING" id="741276.A0A2S5BA64"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="179" mass="18909" checksum="FC20DFFCD6ADA03A" modified="2018-07-18" version="1">MSSHSDDTSSRQGANERLDVPTLPPPSSRFVLPPPPSDLLNRLQAFLPQIRDANALLEQQQATQPEGAAVEEPVVMEELSDSSSDSSESSDDSSDEDNEEDEAQTGADGSLLDLDGLDGKDGDGTNAAEGVDAVENGEGPLARLMDISSRPKVVKHKLLVQEQVDGDPAAPSDESMQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA74</accession>
    <name>A0A2S5BA74_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BA74"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="351"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1317"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1323"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1355" mass="146560" checksum="B1C7D84534EE6325" modified="2018-07-18" version="1">MNEPTTPLCFSQTIPYDPPKVEASSPARVSLPRTKSPPVRCEPANAPASSSSAENQAQPLLLQDVVGTPVSAAAARPDPPSTLPIPILPARPSLSRLFNEQRHQRLLSAAPKAFTPSSPPSLMQRGLVGPAGYFGDSFFRPFAGRRYKDDRESPKPRKPSKVRAPSSSSFSPSSNHLPANPPDLPLPLLAKIGLHRVILPEWSGQRRAPQTVEERSRDVVDSGAGGSTAPNPNPRQSADDTVKCSGWPIADVTTVLTGGQSEFCSSDEGCGKVSGGGGGQAKLPPETPQQLRRPSTISASGSRPADLPHGLAEVCSSRVERALKAKEAAAVPCGTFGISTASEVGGCNTEVNILVQDAEHTFTMTLKVTALVDDLHEALFARSGFDPEYGYLVYGHKVLRANTRLFDYGIRNGSVLFLHARLRGGGQKRIVMDDDDWDRFDKESQRPPKRSAIPYMEWLEDRNHRLERDAVVKDDRIKELRDENDAQEAEVRQARRNVKRAQQSEEKYRQIALRNLDERKAEEELRVGLEEKVARLNSQLAAVQQELNETRSSLTVPASDKKAFFASHPAGPPSPTGSSADPAPPKPNRPHQTVSTFPAFAFLQISPDLPAPTCRPLDLSFLTPPPSPVTPSAPVISTRLVSAFTEELAPSTMLDETGRLPPTPVLPITPASVALAASSHAALVSGPDGAATVLAAQDLTSAPHFFRINSIGGRKQDKSPTEAAKEPMQQQLEQVWLGHPVQSVFAVPAFAGASGGGLTVFDFDAPATTSEPPSVLFKIDPTLAHGKQNIYAALKDEEPLTFARQFPDYCGDVHFRIFLDIISRSERFLWTLFTISKPYLPQLLSCAHLKRWAENPRASGLLLVSHSSVHKAYKLAEEANEKISLHLLSVGINPEEARRPRLLVQQVRTTGVPAFHSKTLTAISKNHTALYVMEGSANPSKQGFGGVASNDHGAAWEPASHETAVVFTAPVHSAFAQQHLLELDSFLAHLAATGRLLVTNSVTTAPIRQLPQVAQAEAALKRKKDETGLSAAEAALASATSQAWSSRFETMDTYEILSHASSSTRSPVSLETDVPAEVAAEQTSSRTAKAKTKRVLRLPNVARTFSEALPPLSASVAKWEFTKLKDGESMIVGEIVCGDCGRQFRGSLPPAKLDSYAVNHPDGSPGCPSKLQPTRPRFVSDEILQAQPDLRQAMYNAQIKHAITEPLTGKLLVQLGLSFYAWLPKSLDSSDEIRTAMSTFLSGVDPAHPQLPGMRHMLEKAQDDFAHLLNFLTKIAAPALGKRFETTKAGRKVRQRPFYAGFLKTVVRHCYSYGGAPGAVAGDGDDEEHDGGSEEEGENEDGEAGDEEDDGPEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAC0</accession>
    <name>A0A2S5BAC0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAC0"/>
    <dbReference type="STRING" id="741276.A0A2S5BAC0"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015759124" evidence="9">
        <location>
            <begin position="28"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="207"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="598" mass="67040" checksum="84B44A06CFF064B1" modified="2018-07-18" version="1">MARLGSLRQLSVPLLLVYSCLIQLARGYQVLVTSSDEVRQVCSGMWGHGKQDPFIEVIFSPMSRGQVALVIFEWDDSKYLGVSPTGKPVENDWAEDRVYICTVEAEQAGLCSDAELGQFLKSSTAPEQTSIYTASVKFDPVPSASASGNDLQQYSAGPYRYEVQKTGYYCVGTVPVVLEGAKVTTEFLGVVDFENVFEGALPANEYPKIAFYRGIFLAYLAFGTFWAALSWRFRRELLPLQRYITATVAFLVIEQFFVWLYYRLLNNGSHPGVAGVYVFIVSALTALRNSVSLYLLCLASMGLSVVRPTLGSVTGRVRLLAIVHFVFGFLYSLGTVTIPVESSGFFVIFFILPLSFSLTAFMTWIMYSLHSTIADLGARRQTYKRTMFRRLFYVLVVACSLVMLLFIASSIAFSSRLDPSFPAKSWKWRWILLDGWLSILYMVNFFIVAFLWRPTGSNRRLALSDELPTDDDEAAGLFELPEDDTERDEAGELKGETYPLTRRSRDGRDEVVFDVGSDADEDDSDDEDRRGSLGRHRRDDSGYDITKQHDDAKKRDAGDGDSGEEDDADGEQEEGETTRLQPGKDAPPPEYRSNQKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAC4</accession>
    <name>A0A2S5BAC4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAC4"/>
    <dbReference type="OrthoDB" id="10501499at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="2">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="87" mass="9573" checksum="42106CC733849325" modified="2018-07-18" version="1">MVRIVGNKKAGSASGTNKKTTSSSSSTKSKSKGKAKSSTGTKTAYQEFMSQTMAELKDQHPSWSGEKRRAEMSRLWKMDPSNPKRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAQ4</accession>
    <name>A0A2S5BAQ4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAQ4"/>
    <dbReference type="STRING" id="741276.A0A2S5BAQ4"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="200"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="798"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1069"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="983"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1254" mass="133022" checksum="B7BD366CF83807F4" modified="2018-07-18" version="1">MTTTTLTHSNLAHIPSTLRLGGIANSGPAAVRSRGTTLAPAQRFLDAVEPVAALRIGEATHRELYQGGGGGGPVLAAVGPGNRGPEIGAKSAGSTAPLGAGGRDHRGARQSRDGNTSITALDGALDASAQTYVGVGRPPPSSSTIATTSTSNDPFRGGSSAMTSATSMQVSPAGSAVTTRPGDPGLVTREWLPPLAPRNWTVLKEVGDGSFGTVWLADWHSPLYVPEGNCAPGPSSRPEYRGKRIVAIKRMKKAFDGGWDECMQLKELKSLRQIPMHPNVIPLYDAFLLPTTRELYFVFECMEGNLYQLTKSRRGRPIAAALFASIFFQISAGLAHVHDNGYFHRDLKPENLLITTTGLTDYPSSRINAPPGAPKEKDVIVLVKLADFGLAREIASAPPYTEYVSTRWYRAPEVLLRSRDYSAPVDMWALGCILLEVLTLKPLFPGDSEVDQVFKICETLGDPANDYGTEEDGNPRGGGVWRRGIKMATRVGFTFPTIPPRQFVTLFDRSTMTPVLIDSIHKMLRYDPGSRITATALLDHEFFRETARRFGPNIAVNLPPGTDPYAPEPIPQPVGPGTNGSATRSVSTLDLSAQRPTSQISERNIPPSHSVPLGRPPAPPFAQPAVVDPTRSRTNGSAQAQVPDSAQAPQAVWSNGAGRASPAVMPPPLHPSAAMPPPQRPADAQSIRSMPETVLSARIAAIRNGLDSRPIGGGPLQRVSSYAPSIAASTYYDGSIFEGATPGRAASILSFPLSDSGVHANGPVAGPSGFSTYRSQSPAPSSIYSQAAAAPLLRAGSANPLKRAPSDASLSSMRLQTPPDDGFSDEEDDEPTELDRFVISGGPDEEEENPKDRARAVMQKKTSLRGAADPLHNFTLKNEGEEDGGDGGSIFSHAGRSFTSSFKGKGRSIMSERMPQIIEDTSRLHVSSPPPGRSAATSSGGFNRHKSRRREGNDDVHSVLSVESGRSAPAWTFSIPGGRGRTYSVSSKATSASDPERRQKPGSDFLGPSEQPARLQSVSSLPDPRLARPHPPVHQSSYRSSMHAPRAAPPSTGHSFIDASLAYQMQGRASLVSRDQAWRPELAQAARDARSPPSPRASSQSRSTSPHETRYAGYSGAPTSGRPPVPSLPPIQSFDTPPATQHPILKRQGTGAASIASFRSTPGTMPSYFAAPDRPSGPAPTVASATTYHLPYLPAMDMDPPGRAAAATQVPLPPSLPLSPAAAPSFTFQQQAPLFAPIVEPPQPSLTPEQLAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAW0</accession>
    <name>A0A2S5BAW0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Abscisic acid G-protein coupled receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAW0"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="235"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="374"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="61817" checksum="58A1FDA7FE6EA7E6" modified="2018-07-18" version="1">MDGALTNTGATARDRNTMMGETALLVFVRLAYFLACRHYVNAYLFADLKDVLREDGLAEDDDAQDGDAVRLDDAENGMFGGGGAAAMVAKARDDRTGSSLLPVSTRRPSDPPRRDSTLSLYGRTPASRAYSTLSTALFCLSFSESSMLFTLLLFGDAVSESARTYNWSLSLLNLLALIVFIIPFGLCLLLTQRSRSGILRTLAFTLVPFGTYLFFFYEVGSIVADQLVTEGSHSFGVVNSLLSRICVPGVVLIASLSGGGAVNTAWEAYEWRSVSSAEAVTDGHIDQAVRALSRTRLDLQQRRRALDLAKGSAEREASEAASRSLLSRWTSSNPAASQVKSLELEIGALEKMERQMSDDVARLKKRKVARELGRSLKGRAWLMSGWLFSLYCIWRVFISCINLIFGYSRKSHQRLDGADPSTVPDQGTDLLTSLLTRLAVLLNVELDIATWSRMIGLALIGGILVANMRSVLGSVSRIFKATSMGVSASFMLLFLAQLMAIYLLTSLISLPSSPSATTTSLLDTLPDFNVFSRLFDSVFLLAAAGIFVSRWIGRQFRDDAGLAAMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBG6</accession>
    <name>A0A2S5BBG6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_2931</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBG6"/>
    <dbReference type="STRING" id="741276.A0A2S5BBG6"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="13">
        <location>
            <begin position="43"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY74119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="354" mass="39840" checksum="656368FCB6AFC097" modified="2018-07-18" version="1">MQKAERRRAPSRRGLLTERREPPPRPLQPLTGKMAAESTPTTLLTDLHVSYIQSLDQNRDELSYYYTEHLRMNGVYWGLTALALMNRQDALPRDEMIKWVMSCYVDQAGGFAPHPNHDPNVHATLSAVQILAMQDSLEILDRDRIVEYVLSLQHPERGSFAGDEWGEQSARFTFCAVATLSLLGQLDKLDKQKTVDFISNCRNFDGGFGMVEGAESHAAYVWTSLGTLAILDRLDIVDSDTLCWWLCERQLSNGGLNGRPEKLEDVCYSWWALASLAILNRSHWIDGQKLSEFILSAQDPEKGGIADRPEDVADVWHTVFGLAGLSLLDYPGMQAVDPVYCMPLAVTEKLVQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBM8</accession>
    <name>A0A2S5BBM8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBM8"/>
    <dbReference type="STRING" id="741276.A0A2S5BBM8"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="518"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="744" mass="78440" checksum="9187DDE9030868AE" modified="2018-07-18" version="1">MSAQQTEGNTSAKSNSLPSSASSSAGPSSTHQAPVRLPSVSLPSADMFDGGAFGGGRRQSINSDPFLHAFSAAHDGAAAHARAAEMFHEDQMRRGPSSNLHHSRGGMQHGPDPSSSAPTTANLDGHASDERWQPPPVGPGFSYPPHSGPPSHADDPNFAGPSAVMVGPSSSYRFGGPSQAPLPPYSAVPNSGPLVAGSFFDPSMRRHSLSRGFNDPPSPGRPDSSRLSPIAGLKRKAQEDIGSGYGQTSPYGSNAENQLGPAFGPKKRPSALAFDSMDARSLQETSRREAPFQSATPWEQEEERRNSDGSYSSAASQPYSMSAYAPSHSIPASAPPYDSRPLPSQASGTSMPAVPSWDGRPPQPPYAHLEQGDSSLFARRPSIPSVSQMMQGFGPAYGAGPPPASAHPQPNLPPRYPPSQMSGPGQPVVTVSSVPHTPTEHEFARLPRSASNPSFPPPPNNGSQPPPPPPPTMPAGHPARDWHHPQPPTRQSSSSSVLLDPAHAASLGKDSPYSRSPELRVSHKLAERKRRKEMTQLFEDLRDALPFERGLKASKWEVLSKAIDYVAQLKQVTAELAQDNANLRQHYRLPPGPTLDAFLLPVDQSHNEDGQHGPMHQSSDAQPMPRAPTEHSGLHASSGSAPPNPSAPSGHSRTGSWLDPREHGIDRKPSPHLIVSSGHSPVIPSRLHAQFGPASQSGSPQPSPSMPPHVAGSGRGSPVFINASPRTFDRPIPGAVANGAVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC83</accession>
    <name>A0A2S5BC83_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC83"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="113" mass="12272" checksum="E7BF313D9FC41927" modified="2018-07-18" version="1">MHAVADFCLVPMGIQEVGVSKYIAECQRVLEKSGLKYELHGYGTGVEGEYSAVMKVIEECHEAVHAMGCPRIATDIRIGTRTDKKGSLAAKVSSVKDILHPTSRDHSHHGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCH9</accession>
    <name>A0A2S5BCH9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCH9"/>
    <dbReference type="STRING" id="741276.A0A2S5BCH9"/>
    <dbReference type="OrthoDB" id="2536882at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="430"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="961" mass="101674" checksum="1E347ECE639CA24C" modified="2018-07-18" version="1">MVDTLPVSVQLGPTREEPQLRPGRRLLEPLGSAAALEKQLRRQSMRPLVPPNPPPMARSWSDDHQRAATVAERTSSLPPPVPFTARNGDASHSFGTAHAGEASRATTEQGRGVEQSVRGEAVRWPHEEGSTTRPAYPNGPSGSAALGTPSSRPVPSRPPRPLAKSSPLHPSAIVEPPTPSSCPSVLSPFATAADNETDVVAPLMRPSASRSPDRSRFRTLQARGGNGAGEASGSSTPGSSAAATGGLSSSASYSSLNPSSALSALGRGWQQAKLKDRLGAGVGYAREWGGKGKGKLQDGWRGFGGTGGAGNNRASVAILGGAGDTTSSGVSSSSASSNSFAFSNSSRTLSSFLSSSSTMPDLAAVGHHAGPMSNNSHGARPGGPSPARGTVKLPAMLFAVSVPDRHGVVFGRPLVQVVEATRTPSLVRPISVDQVLGDDARYWLPGIAYRCLEYLEEWGLREEGVFRVPGRSSHMAELKSMFDAGVGQELDLREVHPSDLDPHAVASVFKSWLRELPDSLLSAELEGLVDDLTIQHLGFGASSSNFLASKGAAAAAGTPTGSAGASPNSSAPPSPNPDPDRMPYLEQLRDLFASSMQPEHWHLLRAVIFHLARLSDHAHVNKMTLNNLRLILSPTLRLSPSFLQLLVAERRILFSRPNEAAQRRFAPEPITQPPLPPRPQGELPRGDGAGRLTPRRIDAGLANESARSRSPVLGADLAPPSPSAIKFSSPASTPTTSRFVASVQEATPVSTDRHDRTPMLGSGSVSAGFDPVPVPETLRVSPEPPKLERLSLGEEFRDAIEQFDRSVAAKVSSADLAFDSEQEREREREQELERLADQTPSRPRPHRKGHSNLSISSMRSFMSSTSLSSNASSYAASSESDIRSARVKHAHTASSSSSFWRRKPSSPANAAIKADRRQSVAYNLSFPVGLGVELPGDKATSQAGGEPGLLSLEERRKLFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCI8</accession>
    <name>A0A2S5BCI8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCI8"/>
    <dbReference type="STRING" id="741276.A0A2S5BCI8"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF2">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="456"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="570"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="784" mass="83786" checksum="AF9AC242100745EA" modified="2018-07-18" version="1">MYRFAGPTQGELASPVPQERRPSALVTDAQFESAVDDKGETASLPLPAAPHRESPRKRRPTVHEGGAGSSHATGQHSFDSLDLGPEYSFFARTASAPPKQTGPPPSGALPPTPPPKLARAKTVTMPSVDVAHPYKPPSGLDGIPGSDEETAALIKSVAESQHGGSPVQHQYQEEAFGESVKLATATAHPLTLSSARHQTAFEDSQPLEHLPKLEAGSTDPTAYPNWHVLAEREVELARLNSGDRLDAVLADPDAAESLRAFAASLPDPRASLLLSLYNDLLAFSAQAATLRLASSAISSSYFLANSPLRLSLNIAQRGPTLAVLYRTAAVGHGLNEPLQAIKREVNEQVLELWVQETSIKKLNARLGMWQVGAGWTGRVVLEEGGPDARSDGLTESFCLTDPNLHDNTIVAASEGFAAVTGYPVPEIVGRNCRFLQGPGTSPASVKPLRDALLRGERVTWTVVNYRRDGTPYYNLICLNPLRDAHGKVRFILGGQADATATMQQVLPAQRSGEGGSRPASFSPSVQEQLDKLQPAHEVQRSSLGTNAAASISNSAIQEYPYLPPANPIPSHILETRTPSPPVAYKLRGRSSSGRSLPKIWKLGHKQKDDSASTASGTNGNRKNSGEDDRASVATSLGTQAGLAVDFVPSNTYTKVALIDATSGQIAHATPELARLVGLSRTAYSSLAGTELVKLLAAPVTDSATSPKDELIKEQTRRLRRNVEMAIEQGHACKNFVRIKEQNKSKFLGVPTKGEKNGELRHAVLHLTPLKCAEGKVTYFAAIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCV2</accession>
    <name>A0A2S5BCV2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCV2"/>
    <dbReference type="OrthoDB" id="2530197at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="71" mass="6955" checksum="3B85F0D0F7A0B390" modified="2018-07-18" version="1">MLKFFGGAGRAEDQTTPKATDQRNPFDLLQPAASAAAPPAPSQAAAALAAASSRKSSIASTPTAASTPGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCX4</accession>
    <name>A0A2S5BCX4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCX4"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="182"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="744"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1045"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1453"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1060"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1453"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1500"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1532"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1596"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1609"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1708"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1745"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1773"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1805"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1940"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1960"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2086"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2104"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2140"/>
            <end position="2177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2177" mass="240541" checksum="9F46C1A86C86BE0C" modified="2018-07-18" version="1">MSGEEQYAPADLQDRISAFLLDCEAPHDLTTPLLAIVENDQPGAKLALVGALHQILASTFSLDEATRPLPQQLASFLHASIFTPIEQAEVEADVKLERKAVVADALLDVAWQLDQQVDTLIPIAWDRQNPPTTAEATNEQAAAASQNGDAKMDVDDTPPSSGQDRKVQSEHAVEQARLRLGSLLRLLVDSGDLPVGALLERLDVSLIAPTGLLPDTRTFTTWEVRARTALYYRQQKFNLLREESEGYSKLMVELLANLGPPHSPLTAEPQETAAERAHRAESINNKMKTLIGNFDLDPSRTLDVLLDAFSDNAVHHWQFFMDVLAASPWAPNNRPGAEKSTNGGDNAKGKQPALDVSIEREEGSDIIAQILGFKFAFYRRPGSPEVPQGLYTTAALLIWHGLVKLKDLWPHLSPTDEDLAKLEGKWRDEQAQLARSVGGANALAMAGALADDEAPAAGAASSSSAAAATSKASTSTAPAPAPAPSPNQKVGLLRSLLSIGDITHSFFILSQYPFLVGAFPDIADLLNRLASYSISPAFEAVSVSSRDPNHAAGFSATRSRVTVDSKGEKKVTPLAQTFALTADAFPNPRHDWTFFFPRWQERVPQASDFAGAVSLLEDMYLPLVKVLVARQPSLLSKLLRMAAADLGTNPSDHPRRTNWLDLLRSYLVPAISMLEHYPAAALELWRVLALFPIETRFQIYGEWKDVHYRRDPALAIRKAEAERDVKALLRRLSKDNVKKLGKTFARIAHTNPAVIFGIALHQVQSYDNLIVPVVEACRYLTDLGYDVMAYSILDALSSSRPKTKEDGTSIAMWLQGLATFTGQVYRRWISMQPSLWVILQYLVNQLVSGNSKDLVVLREIISRMTAIEPFADLSDAQVASLAGGKFLRNEVFQKTEIEKMAQRGQQEGLIKAKLRLATSLLGRGLAIPMLVNIALQRQACLKTDAHLKSLGALFDQNHAILFQYTELLQAIAEPEQLAELVPPVEDLLDRYKLDAGIAFDIARPRLRASLRVHDEKESADLASSRKKQGLLAKLAKEKEKVVEAAAANGTATAPQEETTGDVKMEDVKVDNESGTPPPPTLDEKPLAEDSDVIIMDADEATPVSPAPTMTSPWHPGLAGAISRVEALLPAEARNTIGAGFFVTFWQLTLYDIMYPKDRYDAEINRLKLLQREASSAPVAKADDRRFFIDSVMSIASGLVEEASKHLNARSTVNRRLNREKAHWFADVKTKPDRLRLADDLLQYCVQPRARMSLPDATFAYQMVKRLHAINTPHFHTVVFFDRLTSANCRQLLSSQISPVLYSCTENEARNYGLFLHDVLADLFRWYKDKSTYDSEAIGAQLVGFRRNQAETDKAKSHYDHNAYRAALEKWHGHMVQGFAESFASAEYMHIKNSILVLTKVAPFFPLDYSHGTKLERSVASLLAVEKREDLKILAQGYKAVLMKRKKDWVNRPAAAAETTSARPSPAPAPSAGIKETSATKSASPCVTPAPSLPTKPEVESATGASSATARSSLPVKPGSRLPETDASIPSRPEPERTRSEAEATPRSGLSLAERLRKEALASKRPPPASAEAKMEPPSAPAPARSSSTRPDRTEPSPRSAAPSRASSPRRNESDRDHRSREMGSARDRTQRESADSRPDAHERRDGREAGDRKDDRFASDSRSSREAKHTQDRKDSRTTRHSDNGRDVRDAKDSKAARDAKGNGGMGDSRDGRDDRYGRSEGQSRGSHDLKAPRESTGSTAVPSVRDKDAGTPRDVDRERQRSVESSHSSRASRSEARDVRDSHDSRKAHDARDAGDTRYAGTARDGREHAAARDSRDDRYGSRRDDKRYARDDKATSPERSRSSRETRSERREDSKEERASNDRPRRSDAKDPKYASDDRRSSTRDGKDTRRDDDRERRSGERSKHDELSSSSRRASEKPEEPASASRRNRDADRFAKTPTPASATAADDSRHSRRDRRVSDRKMTREEEIREAEKEKQRERDRQREAEREEAREKERQRDAEREAARDAAREKEHREARSRRFKQPPAEGGAPAARNGLPPKPPVGASSGGDRLRPAPARAQERSPAAATADATTPSLLERARASLPGASASSSPAPSAPAHNEDAKKEEPAAAAATEEFSIKGRGRLFQGLTSLGGSRRDEESSRKRLADRLGPEDPKRPRTEEPSSRERRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCX5</accession>
    <name>A0A2S5BCX5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCX5"/>
    <dbReference type="STRING" id="741276.A0A2S5BCX5"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="718"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="851" mass="91652" checksum="25B3ECFF2AA6DF3C" modified="2018-07-18" version="1">MADLTPCEPFYISAACSRSHATAARPQDGLVAFASGHLNTTSAGVHRTLPGHKGDVTALDFVQSSGKSRYLVSGDATGTVRVWKEQDNDKWSTLATFAGHKGSISAVQGLQLDADQLLILSGGSDSTVCTWRVTENGHDNLDEWKDSARVRFDQIARLTSVDQTQFRKVLSLEGHTDWVRSLSFITPIPAGSPTASTSAAYDIAPGEVLLASGSQDHYIRLWRVSRRIRSDDELATPAANGDEMDELDAALAAVEDAAELRVKAHDFSVDGEGDFSCASEAVLLGHDAWVTGLNWAPADETGSPRLELLSASADRSMILWSPVSAGAAALPDSKPLSSRSAPSSHASVWTSQHRFGEFTSSTNLGFFGALWGQAGRTVLANGWGGSWHVWKLEKETGREEWRPQVATTGHLGAVRQVAWEGEGEYLLSASHDMSARLHAPWRRAVGGESVETWHVENGQLMSLSVGAELGRPQIHGYPLASIAFTSAAKRLQFVSGADEKIIRVFDTPRLWVQTLKTLSGVDAGDAVGSCASSASEERKADVLAEQESRPMAANIPPLGLSNRAVASPDEAAQLAPASTDVFDEILPFNFTVSDHPPFEEQLLGSMLWPEVDKIYGHPFELVSVASAHAAPIIASACKATAPDHALVRLHSTENWQPVGVPLEGHALTITKLAFSPPTKVGTDADRWLLSVSRDRTWNVFERASSDASDHTYRRAATLKSHARIIWDGCWAVDASFFATASRDKTVKIWSSGNWQCAATLRFEEAATSVAATMSPDGQNHVLAVGLENGQIHLFLSADSTNWLPSRILDNDVAHVRTVSTLAFCPAAKITGRVRLASGSEDHSIRIFDIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD20</accession>
    <name>A0A2S5BD20_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD20"/>
    <dbReference type="STRING" id="741276.A0A2S5BD20"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="181" mass="19188" checksum="82899344FBD584D7" modified="2018-07-18" version="1">MFAATRTPMLRTIAAAASRPALLARPAALAAIPRARLYHDKVIDHYENPRNVGSLDKNDINVGSGLVGAPACGDVMKLMIKVDDNGVISDVKFKTFGCGSAIASSSYMTERVRGLSLDQAAAIKNTDIANALNLPPVKLHCSMLAEDAIQAAIKDYRKKNNGKTPVFASDAAKAPKPELNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD88</accession>
    <name>A0A2S5BD88_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Urea carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2199</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD88"/>
    <dbReference type="STRING" id="741276.A0A2S5BD88"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF128">
        <property type="entry name" value="UREA AMIDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="4"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="117"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1233" mass="133625" checksum="9926AB9C5E89B93B" modified="2018-07-18" version="1">MARANHKLLVANRGEIALRIIRSAVELDIPTLSIYTDADAAATHVFRATESVSVSSYIEQDNLIQVCKDNKVTMVHPGYGFLSENEEFARRVQDAGINWLGPTPEQIKSMGLKHEARARAVAAQVPVLPGSELVATVDAAVEQASKVDYPIMLKATGGGGGMGMSICWDESELCKAFKSTTDLSQTLFSNGGVFVEKYIPKARHIEVQVFGDGKGKVIHCGERECSVQRRQQKVLEEAPSPFILRHPRLGEEMCAAAVRLCELIDYRSAGTVEFIVDDSTAQFYFLELNSRIQVEHAVTEMVRPGLDLVGLMIKLGLSADGSSAFELPDQAKVAKPHGHAIEARIYAEIPHLEFKPAPGLLQEVKWPSADWIRLDSWVETGTTISAFYDPMIAKLITYGSSRDEARSRLDEALGKTSLLGTQTNLHYLRDIVNCNEFVAGDVTTKFLDTYEYKPSCIEVVDGGLSTSVQDGRPRLPSGGDGIPRSGPADELAAKVANLLVGNAVETEVLEGTVSGPSLKFWSAAVVAVTGATADVYLDDEKKPMWTRFVVPAGSTLEVGACETGGNRTYVAVRGGFPEVPLFAGSKSTFSAAKFGGIQGREVVAGDIIALAPSSAPSTDDAEDFTLPESALPRYPREWTLAAFPGPQADADYLLPEDRETLYSTEFTISPASNRLGLRFDGLKPLKYSRADGGAGGSHPSNCVEHGYSTGAINMNGDTPVLLGVDGPDCGGLICILGVVQADWWKMGQLAAGDTFRFVQPTPEAASEQLTNQKHWLDSISKSIKDPSEAAAFPLDVKTQPQQVTDGVIKVIEGDEALEAPKLTFKLSGDGGILIEIGDQNLYFRTRLIAELWERRLRQLAKDGIYAYIPGVASLLVKFHPEAVSQADVLELLVSTSAGLARESLDQIVPSRRIHLPVIFNDSGSQAVIDRYMQSTGRKKAAYLPSNIEYMAKANGFGSVNEIETTFCSADWYVASRSFFAGLPMIAPFDMRCVFKSQKYNPTRTFTPAGTLGYAGVMSAIYPVDSPGGYQILGKTLTPWSPWGRYDGEGHEKLFLLRNFDVVHWLPMSEEEFLKIEKQFTAGSYKPLVEEYKISAKEMIEFEKSTRREADAMGATRKAGFEELSKQEAVYVTEYQEELRKAREAEAASGGAGGKSGTMSGTPLKSPVQATVRAIGVSVGDELSNDGEPAVVVEAMKTSISLKLSRALLGKKVTGIAVEVGDVVKPGQALLYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDK2</accession>
    <name>A0A2S5BDK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <ecNumber evidence="5">4.3.3.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDK2"/>
    <dbReference type="STRING" id="741276.A0A2S5BDK2"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="324" mass="33903" checksum="FB9C62608802FDD7" modified="2018-07-18" version="1">MPNAAATSNRFGRMVPKGVYAPLITPFNADQSIDFETFKRHVQYVAGAGVGIVALGSMGESVHLTHSERNDLVVAAREALDADASLKDIPLVVGTGATSTFETIQLTKEAGERGADFAMVIAPGYFAGAMSKKALKQYFVDVAEASPIPIIVYNYPGAAAGIDIDSDLMTEIAAASSNIAGCKLTCGSVGKLTRLTYLRDDFAVLGGFVDFLGPSLLAGAAGGITGTANVAPKTCLKLYKDTVAALSGQGNVSLQSAQQLQGVVSRADWTLQKVGISGTKYALEQLRGYGGVPRTPLLPLDEADGKGKKLLEDLQEILTIEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDV1</accession>
    <name>A0A2S5BDV1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDV1"/>
    <dbReference type="STRING" id="741276.A0A2S5BDV1"/>
    <dbReference type="OrthoDB" id="61390at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015714787" description="Methyltransferase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35034" checksum="BED234AAC7CB26CF" modified="2018-07-18" version="1">MNSPTYAALGVLLVAAVCSLRSLRRRQRTELYDDADAVLLNLRLPQSRWFNMGYWTAGTAADDFPSAAAELCRRVAQAARLKAHERVCEVGYGSGDSALLFAREFEPRSYVGYTSLAGQHQLAARRAVEAKLATEGFELRRGDAARDLATLPAGSQDVVLAVDCAYHFNTRASFLDGAHHALAPLGRIALTDLLIPVSDLSFVDHFLLRALFHLAKAPWQNFLTTSAYRDHLVQAGFDRDSIEMQDISDDVWPGFCRFMRERDQQAGRSTILGSAWRGLSMYTKVVVWYSGARGGKRRLHFYLISARKADLSTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE42</accession>
    <name>A0A2S5BE42_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE42"/>
    <dbReference type="STRING" id="741276.A0A2S5BE42"/>
    <dbReference type="OrthoDB" id="10641792at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36215" checksum="734CDCC2BD4E73BF" modified="2018-07-18" version="1">MTTLSLARARPSASQRASHTGNDSVQRTPVYTLRKRSAPEVELVLGAHSASQLAPKLASHLGVPTSSPPGGPLKSPPMGTPPLPEELTAGAKAAQVLGLDAARSQASSGTASIASSEADHGDILPTFPAKQDAVLEKAITLADLYKYTFTASTMLRAGKATFKQRFIVLARSKSGAEIAPSHEYTLHAFRTANPAEPESARLRLLPSSKLSIPCLQDYNNIGEGKSRLPYAILVTGKGSFRGGRGVAALERDTSWILGMEDQDTYSSWIDALRENVRELVAARQGFSHVAAASQRKLARRLPAGELPGSTRSSRTSERERLLPLRVRLYQRARFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE85</accession>
    <name>A0A2S5BE85_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE85"/>
    <dbReference type="STRING" id="741276.A0A2S5BE85"/>
    <dbReference type="OrthoDB" id="2536866at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="307" mass="33101" checksum="EF8943FFF3B79E19" modified="2018-07-18" version="1">MSLSQATSMPAEYPRDRLSTLPTPLLLRVLATLELPDLVFGVKPASRTLYLHATSLARERALPLWLEQVRQARRSGAPPSATRVSVHVTRPSTVRDETVDALPSYAAVPQAPEPPLAGRLSRELAVFDLFVATLARSLARLSASTLLLTGEDDALRIPGDARQDLFGHLQPKAFCEDCLIAEGRRSGWIVEAPDERGGSSSDLRLTVATSRGASRAASAGRFATVREDDVRVDLKLREARLLLLVHTTSDARSGNAATWKGVATVSRRPEVGIESVARRLAREAGQAGVGPRDALDNVILIVRTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEP5</accession>
    <name>A0A2S5BEP5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEP5"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="226" mass="25034" checksum="C5C54261222C207E" modified="2018-07-18" version="1">MFELASDGPASKQECGVSETSTELAAFASALDGKTSHYENTWLSLQRMMDKYDVPMLRTVLLLSAREALARDPLFAFSAAAILSDRTLQQEAEISCLGADMSAIKKKIWLQAPEVERLRLRLFDAQAHKIALETLSSGCAGPEYGTPAAHANKCPSIPGDRQTAYGDALLLILNRTHRGGISRTVSDVELLDFPNNHPLHSWCSECKEHLRNRLGLLAERWRDQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF10</accession>
    <name>A0A2S5BF10_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">A/B superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF10"/>
    <dbReference type="STRING" id="741276.A0A2S5BF10"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="515" mass="55032" checksum="79826AB2A549E04B" modified="2018-07-18" version="1">MAGPSVTIYPPGAAPPVADNRFSRLIPSQSLAVVSEFTLESGVTLQDVSVGFRTWGKLNDARDNVMVICHALTGSSDVEDWWGPLLGPSHAFDPSRYFIFCANVTGSPYGTASPVTKNPSRSDGGWWGPEFPATTVRDDVRLHKLLLDHLGVETVAVVIGGSMGGMAVLEWPLTAPKGYVRNICPIATSARHSAWGISWGEAQRQSIYSDPEYESGWYAPDGEGPKRGLSAARMAALLTYRSRDSFESRFGRKEVDSDSESAKKGAGGAAKRRIGAVVGRGKVTDALGLPRTPAERAEAVHNDGHQPFAGASRPASPPPSAASLSSALSDVAQNGGGESEGDLPLKPNGDPLPPPSPPSIFSAQSYLRYQGDKFVSRFDANCYIHLTRKMDAHDVGRGRPASPPPLSLIPPGALVIAISTDGLFTLTEQRELAASMPDAELVVIDSPDGHDGFLLEFEQINEHVLRFLHARLPEVYAGAPLVDPDRVGDADKGFDVKKASLFGEAEGDDQDITRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF35</accession>
    <name>A0A2S5BF35_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichome birefringence-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF35"/>
    <dbReference type="STRING" id="741276.A0A2S5BF35"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF48">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42768" checksum="B75DAA9C34B9322C" modified="2018-07-18" version="1">MKDVVLNLPLQTDSKTAAAEWPPRPRCLAFALTVGVFLYILPLDLLLPTRPFAILSRHLFGERYCHPEELGIGKWLLRTEDAAVDGHTWPRLKASVGYGFCEDANRTALSCASRHPDGLRQLQKLNRWEWKPHGCAIRPFDPAAFVERLAEIAEKGKGGRGLLFVGGRSAQRQAQSLECLLGQYVDKGSLTDANRSGVYLAENAGKIEFVRNEYLANPVDWTLSLPEDADPILANDTTSDRWTPLVSDKAFIVINSGEELGPLTPARLARYTDTAKQVIDFIDSRSQATLIVRASIPPLPLACTVNTSSTFESSGVTSAETRKAADIEAFNTVWKDLLWDHPKHVFLDVSNVMASIPPPANASCLRDCLPGPTDTWNTLLNHVILQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF63</accession>
    <name>A0A2S5BF63_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF63"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="118" mass="13197" checksum="5E45827C29107B88" modified="2018-07-18" version="1">MPGGQAPNVVQQPPTDRRTRPESTISSFSLSRTFTRSSRTPQTDTCLHLPTVFRCSGSLAVPRCVPAAEAWKEDQVHRIQAVVRQHPDRGREGVRLGVVRRLPERPPAQLAAVRRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFH1</accession>
    <name>A0A2S5BFH1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFH1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFH1"/>
    <dbReference type="OrthoDB" id="2524932at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13704">
        <property type="entry name" value="Glyco_tranf_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50650" checksum="9D7940E7F2753308" modified="2018-07-18" version="1">MLVFHVRLGRFGGRVAGVALLSLAALVLLSHFKAPWGHLSRRIARPAPATLRTCSQSDDLAMPSPSELSATLESLLTVPANEVGRIAICASLRNEGRFINEWLLYYRVLGVDRFYLYDSGSDDDTLSALQPWLRTGTVQLHRFRNNQEGHYQTTALDTCSRTYGPKTEWLVEADCDEFLVVVPTLLSTDHSRPLELSDMPNRPLYILLDSNWLYKNADAVVVSRLTWKNAGFERLPDGVSLLSLQTVREYQHSVLFDKLLFTKSILHTGKKRTGWSIPGAHFLRSPHATAARIVTSNGHLVDTVPYRADTDEGLQYEGRFSGGRIFEPLVLYHYVERDLQDCYSKLRVAHKLRKGGYDVYEDPDSHTPIYDQDGFYGAATTDRTMADSWFGRFLPPLLAALRARERDDVEARRGPLLPQIIEPHPELVAEWVAEGLDPTNGMPLTVTKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFH8</accession>
    <name>A0A2S5BFH8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Acetylornithine transaminase</fullName>
            <ecNumber evidence="7">2.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFH8"/>
    <dbReference type="STRING" id="741276.A0A2S5BFH8"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="442" mass="47730" checksum="44C3482988208000" modified="2018-07-18" version="1">MAGLAQIGAKHVAKGVGRFTEMVMTEGKGSYIKTECGRNILDLTCGIGVTNLGHCHPGVTKAAQEQVGTLVHGQVNLGYNKPYLQLIEQLLPVMPHKSLDSFFLWNSGAEAVEAAVKLARHATGKQNIIVVQGSYHGRTFGTMALTKSKTIYGAGYAPLMPGVFTTPYPYWHQMGLPHTTSNDELVENALYRLELLLKQETAPRDTAAILIEPVLGEGGYIPAPKGYLEGLRKICDDHGLLLIIDEVQTGFGRTGKNFAIEHYPTVQPDVMIVAKGIANGFPLSGICSRKELMDKQPAGSQGGTYGGNAVACAAGVAVQRAFKEEKILENVEERSKELFGMLRGLQGDATVGDTIAEVRGLGLMVGIEFKSPTDPYTPAKGKVPAKMASRVQNKCLEKDLLTLTTSIYETIRFIPPLNISKEDMAKACSIIKESIEEVVREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFQ5</accession>
    <name>A0A2S5BFQ5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_1226</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFQ5"/>
    <dbReference type="STRING" id="741276.A0A2S5BFQ5"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="247"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY75604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="454" mass="50093" checksum="48BFA79AFEEE5C08" modified="2018-07-18" version="1">MRELITLQVGQAGNQVATAFWENILQEHGLDNDGHIVEGASHVQTDRLDVFFSEAAAKKYVPRGIQVDLEPSTGDAIRSSKLGHLFRPSGFVFGTSGAGNNWAKGYYTEGAELVDQIMDQVRHEVEACDNLQGFQLVHSLGGGTGSGLGTLLLSKVREEYPDRMLATFSVLPSPKVSETVVEPYNATLALTQLIEHADLVFNFDNEALYNIFNKTLKKSSPSYAELNSLIAKVMSGITTPLRFPGQLNSDLRKLATNLIPFPRLHFLTSSYAPLVAPANKDYARLKIADLTQQLFDPANMMAATDVRSGRFLTAAALFRGENLSSRAVEDAMQSMQHKNADYFVEWIPQAVQTALTSVPPVDSPVAATFVSNNTCVQDLFRRTHTQFAALFKRKAFLHWYTGEGMDEMEFTEAESNIIDLVAEYQQYQEAGVDDDEYAGEEYVEEGGAEYAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFY8</accession>
    <name>A0A2S5BFY8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFY8"/>
    <dbReference type="STRING" id="741276.A0A2S5BFY8"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="86"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="319" mass="34347" checksum="81B71B4BEE79EFB5" modified="2018-07-18" version="1">MQASARALTRRLRPVAAPSPFTWLSPSARASSTPRSASRDLTTSPALYKAKSGSSSQWLDRQRNDPYVRARAAHGLIETANAPSSYVSRAAFKLIELKEAWTGDVRMLRPGMTVVDLGAAPGGWIQAADQVLNGKGTIIGCDLLPLHTSIPKDDGSIRFVQGDFTTSAVQERVRRIVEEETGQDKVDLVVSDMMGNATGNMLRDSTISLELCETALSFARAHLAPSTADPTSRVAHPVQFVVKHFTSAATAPLRKRLASLFYVVKWIKPHSSRKGSREGFFVCAGLRPGARSSHPVDPDRSGSAAAPAAGHPATEDLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG06</accession>
    <name>A0A2S5BG06_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG06"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="50" mass="5406" checksum="FA54599708A1CFA0" modified="2018-07-18" version="1">MLVLQLMSTLARTPDGPTPPTVARSIGISGEGAHRRALIYGTRRPAEYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGH9</accession>
    <name>A0A2S5BGH9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGH9"/>
    <dbReference type="STRING" id="741276.A0A2S5BGH9"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="308" mass="32309" checksum="0AB84820BC065F20" modified="2018-07-18" version="1">MATRRDRSSTALRPLALSQGLLSRADGSAQFSFGDVAVLGSVTGPAEVRIRDELVDRATLEINVRPLRGQGGPGIKALEETLASLFTPLILLHLYPRALLQLTLQTVSSPSTAFSIPTSTDPLLQRKGKGKEEVVPTPRGVALGASERAATINAAMMAVIDAGVQSRGMLVAVAVAFVPRTKAADQEEEEEMVLDPSPADEDQATSSHVFAFSFGVGVGGTQGTCVCVDSVGTFSEDQLFDAQDLAQSACQTVLAFIRKSVETKYGAESGPAPVTTRPAAAADAEEEPMADASEENESSDDDKVMIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGK2</accession>
    <name>A0A2S5BGK2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGK2"/>
    <dbReference type="OrthoDB" id="3249298at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="255"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="454" mass="51546" checksum="54CE07465BE93834" modified="2018-07-18" version="1">MARGELPEKYDTDGVPVGFERMIRQRLKAFLSDKSNRRLVVHHSRNSYTGLERIQASDTRSGSMTRDEADRQSAGEHVARLADRQKDAKIVTKDGEDVAYVLRNVLRESKPNVGSRGGRNHNAGTEARAEGPQTPVGEDNMHRLVIGLLNEWGSTSKRAPSASVRDHRYRNETPSEWEAARDMDLSFLTRYLGMTREQGHHDEKWTVKTAADTIKTSRDVDYIRAFLGQIAAFWTAVGVTMETLQPQAMNLFQETFDRHRRSNVLADWINHSWLFFMSIVLVSNRRVAPHFDASDPLHGWAASTPFGSYTGGDLFFIDLDLRVALKPGDLLVFRSALLRHSVLPFTGSRHSLVAFTHEHLMVHTGIPVKDRAPFLAATTGEDPTWPIRDLESLKDRRLWDSSERLRERKEANRREEARRQQERAAAIAAKQAWSGKEEATGRPDCASKKRKTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGL1</accession>
    <name>A0A2S5BGL1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGL1"/>
    <dbReference type="STRING" id="741276.A0A2S5BGL1"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="596" mass="66238" checksum="3E4E152F93E62105" modified="2018-07-18" version="1">METESALSTALLDEMVAYVSAKGTVEQSQDLVARLAEEVDRDEQSLSRKDSRVSDTIFDNTFALVDFLVPLISTDPTAEPLQVPVKQCLASVARCSSPREILMAVEEQLRALLPRVSIWAGSGPDTDDKLNNSPSRYAALLAPSAIAIRRIALPKRLKFAQTFADDARKAIGRLTEQCMFQSFSEWQEAEKRIVIYDVASETQSAVDSIARSLEAQDDSEAETDLQAAENALRFLLLETIATLHREMGCDLSSSVYATKGVGPKQPQTPSSTDNRDLWERILSTLAVLATSPFLLMSLSVKQRNPALFVGAFVALVHLIASDPEKVDPDELGLDGRELFKHAIMVRVTAMREEKYKLGEDEQLFWCYWALDGYLQQADETNSGARYALTAILNWVNPLAASSTDPTVRFLAFRLIARVLLYDTDGRSLRSDEQLQQDLLTELVVECPDNAMRAAAVGLASEDSIFFDEAFLSTPLGRALLSPTWARKQPWAKEADETLPPVLPTCRRFLQSEVGGTMERLSLVFVLLKDAQTRRTSRGDTPLVCTTAQRNLLEPIATALAKWRPSWDKLKPEERLELELVVDLLQRVQQVAQELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGU1</accession>
    <name>A0A2S5BGU1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGU1"/>
    <dbReference type="STRING" id="741276.A0A2S5BGU1"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="68103" checksum="2358806E359DCCFD" modified="2018-07-18" version="1">MNLGGTLSSTSPASFSRETSFLQQAIARGDNSLHGTANDLLDANGTATRGRAKRRSGSSGGATGRLSFSAEGRLSPPQESVDEEAEIEDHETATSDDETAVGAPDEATQRLLSDSGGRRRLSRAPASFHPATENTPLLGHSATTDGVTTAAEEAAIREARRLDDNRRDAAIGETKVLFKYTAPILFTHFLEYSLMATVVISTGHLGETELAAASLSNLTNNVIAISVIHGFCAALDTLCPQAFSSSRPKDTSLYAIRTFIICLIIAVPQVVFFFNSEWILVDGLRQDPAVAKLASQYLRIMSFAIPGYAGFECIRRWLQAQGLMLAPVLALIVAAPINIFLNWLLVLGPVDSLRLGFIGAPIASCVSINLMFITMLGYSILFAPRDAWSGWRPDIMSGLGLNVKLGLAGVGMVGSEWWSWEIVGLATSFLGPTSLAAQSVLLTSASAFYQFQYALSVAAAVRVGNLLGAQKPHLARVTSRLTIVFAIVCSGINSILLLLLRNVWGTFFSSEPEIIALVANVLPLVAAFQLWDGLSGAMGGVLRGAGKPTLGAIASRFPLCRYLLINTASYYVLGLPIGITVAFVGPKLGLNGLWLGLTIALTLTGLSSTYIVWFMDWEKEAETTRIRLGEAKRDPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHA6</accession>
    <name>A0A2S5BHA6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHA6"/>
    <dbReference type="STRING" id="741276.A0A2S5BHA6"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="96"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="264" mass="28775" checksum="61BBEE4180A77336" modified="2018-07-18" version="1">MSEQRGYIDFAAGDQATHGEALKRYKDLAAWLERNGSKYGLPARLAELDHSGRETVVAVYGGDAQVELASEDLSPPRSLRLPRLRFAVSSSPALKKTTANFLALLTDEKKLVSKRPPNPPLRYVETPVFRIESDFIAQTGDITRRDGSGGESIYGGSFNDEKEGLKIAFQKGTLAMANSGKNCERSQLGCLQYSAVGLTPVPFFVTLTDDPSKLKKLTGKYVAFAQVDLLDADSLECLRQLDALADGRGGTVKPVWIDECGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHG2</accession>
    <name>A0A2S5BHG2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Purine nucleoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside permease that transports adenosine and guanosine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NUP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHG2"/>
    <dbReference type="STRING" id="741276.A0A2S5BHG2"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015738960" description="Purine nucleoside permease" evidence="2">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="41588" checksum="52C6A0244D836CD0" modified="2018-07-18" version="1">MLSALKAVAALAIAGSVIAAPALAAPAKRSLTVDGTVVKPKVMIISMFSPERNVWLEPMQLNVDYPLVGGSPLFPNISCEAKREVCIVTTGEAEINAAATISALTLSRTFDLTTTFFLVAGIAGVNPHMGTLGSAVWARFSVQSGLAYELDARQIPANWTTGYWALGTKAPGQLPAVSDLYGTEVFELNTNLLARAVNLTSGLKLNDSSVAQEYRKYFDFAPANQPPTVTQGDALCSDAYFAGNLLAETWGNYTELMTKGEGKYATTAQEDNATLEAMVRASKAGLVDYSRIMLLRTASDFDRAPNATVSAYGAFEAEQGGFGPAIQNILITGRPVVEDILKNWDSVYANGIAPQAGLNGSYYGDDLGTIRKGSAQARRYRRSLAAAAAAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHG4</accession>
    <name>A0A2S5BHG4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000007">
        <property type="protein sequence ID" value="POY76202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHG4"/>
    <dbReference type="STRING" id="741276.A0A2S5BHG4"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="514" mass="57804" checksum="5906801413F9D5C7" modified="2018-07-18" version="1">MNSRAAAVMGPPSASDDREHSTCVVMGAGLSGMATAIQLKRKFGLDDVLVYEKTDDLGGTWNRYPGAACDVPISFYSFSFYPAYHLKSDWASRERIQEYLHEVRDKFELCNIVYRTVVEEARFSRDDGLWHLRVRNLETDEVRSRTCNILFACLGGLAIPQDPPFDPKSFKGDVFHSARYPKIYDLAGKDVVVVGNGCSAAQIVPAICHTAKSVKQVARSRQAFLPRPPIPDHPFLRTLISYVIGLGWLFRSAIFWFAERQFVLSDITEGAKKRSELKQVITKYAQSTAPQRYWPVLEPDHEVSAKRRVFDMGYIQSLNEPNVELFSDDAVVKAEGTTVFTEKGHELRADVVILATGFKVRDYMFPLKLYNSEGESLQDRMKETGSKVFQGTCVSSFPNFFWLMGPNTTTGHSSVIFTSECQLSLAFHMIRPVVAALRSDSQPISSRSTRKAAAPFVEVTRKAEDERYARLRKEMRNKTWETNGGVSWYTDKQSGPVPVVASPLLAQVYLPGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHV0</accession>
    <name>A0A2S5BHV0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHV0"/>
    <dbReference type="STRING" id="741276.A0A2S5BHV0"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF11">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="663"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="96518" checksum="4FBF8D169FF5D878" modified="2018-07-18" version="1">MRRCFAASLARGRSAPPAAPPIASYTPLDVLAPAFGRTAAQVGSLRLYASSPPPASKAAPASRNAQRAARVDQPVTKRSPAKPRKRKSPRSVAIGETPSAVNLLSQIRGAAPSAGPSVPGASAPHGDAAIKAHNKAVHSLLRGVSGPELSFQDAFVDGWLPLRRTGQAGRVKARDLEQALLSTVTLGAVEVAARYAPEIDELALYLAGETDTPALANWAWATLQQDAAGSGRVVELWHRIRRGDHLTLRTANDGPCSAHRSLATEGSPAKARRKPPSLYAAYIAAKAMVLQMTHAPGSRWFASALPDLLDSSAPPLAPLLTRPDLAERLDILARGSSRDAETAKDPDFLLSVVRQVSLAQTYYALPDRPGEGLYRDVSSLFMRGQWSKIDELWQDVRTAVDHPDLSWLDCSAWSRSARRSPLDQDGEDASAQLESLDSGMASPISPQPPTEPHTDRAATRVATPFPTAVFTQQLVARFFSGFVQAQKTDSANAIWAWLSGREPPLPPGVACWTGLLRGYSARANVASVEAVFADMQRTPGLEPDYFAWMERVEAFFEAKQPDEAMRVAREMMRDRYVLRDLERAGAASAFPLRMWNRLQSGLLTNGRVKEAEALLTEMEQAGVAPSITTVNAFLKYHARGSKPDLAGISRVLQLVADKGLAADVYTFTMLLQALLAVGHRDASAKTIEIMQATGIMPTATTYGALIHSLASTGEAEHLRAATHLLDEMESKRMQTNEIVYTSLIQGFLRAGEAAVVDDLDAATGLPQGITAALTLKDRMERRGIAVPRAAYNVLLSASLAQRTEAGKVLAFRLFREMKQAKAMLARGNQEKGAEANSVTVADTWYILLDGFSKMRDDASAAAMVREMRESGFTPRSKALLRLVHRVQKGWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHV1</accession>
    <name>A0A2S5BHV1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHV1"/>
    <dbReference type="STRING" id="741276.A0A2S5BHV1"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="301"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="508"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="745"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1105" mass="121259" checksum="35DDEEA7A270427C" modified="2018-07-18" version="1" fragment="single">SPRRAEQSNSASLTSRQRSQAHGRALAQLHTALSAASFAVALAVGLALHYRKIVKNQYYGYPDEWFPSVSATVGDWFPERNLFQILIALTSGPRFLLVLVAYIAHRHARPTSSLPGTLAVVGALRTLMCGGWVFVTSTDHGDVHDVCMVAYILLNLPYMILHTILTPLTSAPEAKSLRRVLGSGFFGALVPLVYFYLQHKQHRVAGAYSIYALVEWSLIVLDVTFDSIAILDYPDSPTAPPLQLSISPIDKTLFGQDGSRVFFAPMTAEPQEPGMLAKAWAKVEIATAATRHFAADIYLGFLYWTCVTALAPMIFYSAVWAMGLSGDEILLFCVISPFLLAFPPIRRLFTRPSIANLGVLIGIASVYAGDTDGEAGASEGEGILRLRLTGLGLAWATMGQVAGWWEARYDGQRLEYKTTTLLLGLVLSNVVKFANFSLNPLWPFMRASSDPKLENGGWNTFGLVLGAIAYLDSVTRRARAVPRPAVAAMEKNAEARQPRPTWLGTVGSVIGFSSSFFLIHWLFTDSGTIIAWSFEGYPATGPFAFPHGLLTISALSLGVALSSLPYSTRIASSVAAYATASLSAALLYSLTYWTAFLSGCVLGVYAVSTFPAFVSSILFHSPTRPALTFGMAFLLYVVLQLASTWPVAYAFVPAGWLLRERTDTVLGIVMTGVGIGILALRPLQKRTHAAGARSRQDVALVRSSRGLSRRVNGSILFLLLTGTLVLLYRAPGYFAPGVPYRAQERVVTAAIWTVHFGLDGRMWESQRRMADFMRDAEVDIIGLLETDNHRIVGGNRELTQWMAHSLNMPYTDLGPGPHKNTWGCVLISKYPILRSSHHLLPSPHGELAPAIHATLDVYGVEVDVVVAHNGQEEDPLDRELQSRELGRIMRERWPTPTIFLGYLVTHPHAERPAPYKLVTEDASMLDIAPKDNDRWCQYILYRGLHRVAYARLNRGSDPSVTDSEVQLGKFVVPLIGAEGSSYSLKAEAALAALRSAPDFNASDPNSLRVPPIPLDEYVSHLHSTPAPTGTEPDQTTWTPERYVPESLHFPKSFYGQGVNGHRYIVLTGQAGEEAPNYLMAEREKEWRRLQELDDLAQEAAGCPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHW5</accession>
    <name>A0A2S5BHW5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHW5"/>
    <dbReference type="STRING" id="741276.A0A2S5BHW5"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="12"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="325" mass="36593" checksum="6AE78DD88AE60C68" modified="2018-07-18" version="1">MTTNSTDNSFIEDGKLYIVPTLSNETFGNDAIMNGYVLNLTTDGTCTGTTDQQCAVYSSNQTGNYSVLPPIRSARLTTRLSHSIRYGKIAVKARMPTGDWIWPAIWMLPTNNVYGQWPLSGEIDIVETKGNLAKNSWDLDNNVMTSSLHWGLDSNSDMYKKTLSWRKRKSLALLADRNFVNQASYVYGLNWDMKGFRTWQSKPSWVINKLNFNQPFYERGNLADALVNGTHPGNPWVASNNTNAAPFDQDFYLILSVAVGGTNGWFPDNVPNKPWSNQSPSAARDFWVNRNVWLPSWPTDPKKRGMEVESVKIWRLAEAGETCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI04</accession>
    <name>A0A2S5BI04_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI04"/>
    <dbReference type="STRING" id="741276.A0A2S5BI04"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF161">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="388" mass="42361" checksum="0F77DD2384A2270D" modified="2018-07-18" version="1">MPSIAQGQGDPNFPPNLDIAPSASAVNRVTRENAAHVESDDAVQDIGRFGIAGRTWEAAYLLRDYCRPPRAGGAIFDPPCPLVNREPLAPTEPAKRKRPRTIVEVGSGTGFLSLAIAPYLAMESSHAQTTLVMTDLDNVCPLLEENLARAEKRWSGSKASDVPESQPPRVLVRPLPWGDQASFRRMTDEDGLYPDIILASDLIYFEFLYAPLLRTLLALTEPVSAAAESPVVLFSYKVRSLTREEPFWRAFGRWFAFEPVQVGRRRPEEKPTPTEGAAETAAAVPPPTSASDAMAWSRYGAAVAESTSQARSDGDDDELYLFVCSRHPSTLGALREEGSPSKKQSRAGATLFGHVTDAELLHGVGPAKGYEARAARFEEILLADLQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI73</accession>
    <name>A0A2S5BI73_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI73"/>
    <dbReference type="STRING" id="741276.A0A2S5BI73"/>
    <dbReference type="OrthoDB" id="2530499at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1124" mass="122668" checksum="335CC4A79CB85509" modified="2018-07-18" version="1">MADDPFPLFHLSDLDFDVSAERIPLLPAYQLALAPWSTAWSDALEPALKRTWRRKRERARTQITNKVPYGKDAAEEDRQKEPFPKFELIPLDFDLSAGEAALDGLTSAQLAAIQFHPSGTKDLVFAAEDIFFSRRERDFAAGLSLPPFEPETVAVPAAAAAATTVPNETTPAAIAQAPLHPVVAVTTPAPTLAVRPEPATEPRAIVPAPVVAATQPAPTPTVVSTAYTLPPPVTAAPAPPPALLLSPGTKQRELERAEYRRPQPVEAAARPQDKPAPAASERSASKDRERERERDRDKDRKRGEARSRSRDRRGDRSRSRDRDRKERERERDRERDRERDREREKARSRRSSRERSDRDRDRDRDRERERSDRDRDRDRNGDTRGRRSSGRDRSRSCSRSLDRSALSRRLAEEKRLLVSSGGGRDGSDSRDRLEPSLSSSAAGGAAYRKRAPSPAASEASLWSSVRRRLDDNVDNRLPISRRTPPPQMPLPNEEIPQALQYELKTVFLRHFPGQLQAGEIEAWIRELLAKAHYGTPFAPVGIKASHKRNTDRTPGQDPWVTLAFVAYRHEREATTVVQATNAKEMHDRKIIASWSTEATKRHSWKWSDFTPEFVEEEHRRALAMYAASRSASNVLPPPPRTGPSDRSAMIPTGPRAAAASAPPTSAADLPDQLVGRLAVLYVTNLPRTTNLSECRNFFDVCDHLVGLALVHPADGYADESSAWLAFETDMHRDKAKHKLYGEKYPGSFKKLWLEKAEDHARKTGEAYVWKWSDMSKGYRQQHATEYERVRAFLPQSPTMTRRAAPPFEPVQPSPQAASYAPYPTAMPMAAPLPLAAPNTGYGGPPVGYPGPPAHVLQSGMQTMHPYAYEQQAPGYPSTGLDQAYSPMQPLLPGPYSAVPRPSASFVHALGTAQSHSPHVSSANTPIAPRDTPSAGFAVSSLSGGHINPARLAMLQASLDAAGYSSSLPNTSLTAEARPDAATEKHQVEEATRGAWSNVRRPSDADHRPVASGSSVTGSTLLNVKGTASQGGQTPLAQAGSSIAGSEIMPGRPEGDDAVPRPSALHDSANSAAINGTGSQRQQPATLNGANGSKQDDPTPSSAGAPENGSADSRQVGEGGAEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIC6</accession>
    <name>A0A2S5BIC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcineurin family phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIC6"/>
    <dbReference type="STRING" id="741276.A0A2S5BIC6"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015423183" evidence="2">
        <location>
            <begin position="20"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="75"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="4">
        <location>
            <begin position="391"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="679" mass="76643" checksum="07A6D4925380201B" modified="2018-07-18" version="1">MRQHRAATTLLSWTWLVSAARAALEVFPPTAQQQQLRFSTGHHPHKQEEQVTQQPDSSDPADWPYRDLPWGQVNFIATTDTHGWLLGHQRHEPSFSGDWGDFYSFTHRMKQEARRRGVDLLLVDSGDRVDGNGLVDADPHVKGSTALDLFSQIPYDVVTTGNHELYKYPVADYVGRVMHDKFRERWVVSNVNISEAGDDNDDDDALGKPFGNRFRAFKTEQGRRVTAFAHAQGTIVQPPSAMVREPWFQEAISTPPDFFLFVGHMSVDIEPDSEWRIVVEAIRQVHQRIPVVVFGGHHHVRQCARYDEYSIGLAAGRYMETIGFLSMSGLDETATKAPSFRRRYLDQNRNTYAYHAGKNFDTPRGRAITQRLSDTAAAFNLTDTFGHAPQDYFLYRYPHTSEHSVLNLMTREVLPKMVTRTDRPYEMLMLLNSGSIRFDIFKGPFTRNDQWIILPFTNAFLYVPAVPRHLAAKLLHYLNIVGEHGLTLSGIASSSSADAAYLEGDLALAADAAKLEHRYRRAALAASSEDVRPFPAAVRASRPRKDRRPSEGYVTLDPAGCASVGGAAERYGDDTLHRPFKSSWQPVFVATALPPSVRPNSDLDSGLGSEGEEDDDDRVDVVFFDFIKLDILSALNALDLASTSASTRQKRWSEEDVRVYLEGMTANTLMEQYARRYWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIF0</accession>
    <name>A0A2S5BIF0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIF0"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="56396" checksum="6BB3886366435911" modified="2018-07-18" version="1">MPDPSSAGAPHHEGDHPYPHHLAQQLPPIQFESTGSAGNPSPRRDSGSAGVASTATEEYTEKGDPSVAHSVHEGDVEKGEATAVVPPAADDFPDVSSPERGASLSRERWIPAFVLWRAKIDILPLVLQVMGSVLSRPAHTVCELTSPVAGYSNSFGVFQTYYADHQLASYSSSDISWIGSFQLAMVLACAFFAGKAFDAGYIKYLLCAALLFYAAGLFGLANATQYWQIFLSQGVACGLAAGIAFLPAASSVSHWFRRRRATALGFLATGSSIGGIVYPIMQNRMFVSVGFQWTVRAVGFLTIALVGTAALTVNSRLPPRKIGNIFDFSPFREKSFALFVAAECIIMWGLYQAYFYIQDYGALHGVSHNVTQYALAILNGASVFGRIIPNWLADTYGPLTILTPQCFISGLLIFLFIPMCKSEAGLITFAVLFGFSSGAYVSMMPATTASLTKDMRQLGHRTSLLFLAVSLFALTGTPISGAILQHDPSYKGSMFCAGSFVILGSFLNAATWWVVSKEKGTKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIF7</accession>
    <name>A0A2S5BIF7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIF7"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="328" mass="36276" checksum="C8DFF081D5EA37EE" modified="2018-07-18" version="1">MAQQIRDLAQLAESCVPQGVHRDGAKYGAFERANIAGWTAYNLALLGPGGFPVDDALKTVLQNELHALHEARNSRTCLDSDVYSCIMYEMRLDVLGLKRSIVVPIAQDVWRDAEARAVHARTAHLERTLHIEARVAEGLHNTATNQLELGACSRVWNESKLRRAVRKLVSLFPDNRRGNAPEKDWAADFYTSLGVPRVKDVAELTYLEQGAVLQFLDVLHAAVAEHARLGSQQGFADALAVLTAWPGERIRRSISYQTALAYGDNTAYDRPQTGWLNGTFLPVRPLPQAHAPALQAQSLGSEARIGWRAARRYGYGSPAEFARQCGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIP3</accession>
    <name>A0A2S5BIP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIP3"/>
    <dbReference type="STRING" id="741276.A0A2S5BIP3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="957"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="614"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="914"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1161" mass="121613" checksum="4E8DE9D11E0870B0" modified="2018-07-18" version="1">MAPYQGRFPPRPGAGAAPPDLSDRLGLRQARHAPAPSRYSYEARSYQAGHQPTQTRDGRRPAAPAAHRDSTSSNLLARLDGNEPPSVQAKRTEPAAKGPAKPQAPLAARLIAEYTTGSNGGQSQSLSRQTSEDTRWSNKGFQPATPVGGKPGSSSAGKQQSKPSHATDLSSRIEPKEARSRTRRSPVAPGPSRLSLEDRISSTIVNHIDLTQDTSSPVAPAIHARAPSRGSRGNTPVPGRSAPSLLQRLTGPPTQANAGHRESASRQSSVASDMSLSTSDVAASSPPRPVPPPDLVRSDARREVAPAANGSTATVERRTTGVQQQQQGPAFVEHREALRPDRHRSHSATRPTPAQLAASSASASQDQNPIAQPARVQPPPALPEVAISATLPASTESAASSTNTGATGGHAEPTIAGSRPLSATSTGRPPSPPRTAAAVTARPALGQQTPSTIPRGSAESSTSAVPQNPPTAPATRRPRQAEAGTPPLVNARRRSNSAGSVAQPISGTEAGTPPLDPRTDVLASASPAQSADPTSADAGETEGAAQAVAAAAAASHGDGAAPAVKIEPRSTDADRSLGEQSAVRADADVKPVVDAGAPSTAVSRRDPPSSRDALLEEQRKLKAAQQELDMLRRQEALLERLRKEREASARAKEHAENLRNVEAAEKAAAATKRLRENLDREKAQLEAAQRAQRATARPSQTTAAGAVLPGAPPLTASHTPAVKSPDQALPQTAQIVAAATIGEQTWAREVPPRLPPATYDWTRYSHHPVMDAVVQQRDALFALQRKCDLAGLQAASRSAVARQLAKYTRNSQQGQFSKQGNRLRDYTSFCSDIGVPPFPISDALLVLYAAAASPLEAGEKKRKQFIYSLRGLAKAIEPLWHRNAEYEQLRGWPTTALALATWKALGNVRNARNAHAHSSTSASSDIGASPFSDERTQASVGMAASLALASTSKRAPNGLSPLGIASGDRGKSAATSADLTVLPHRKRPSSPSVDDTPAAKQPRIEVAGFAGDGNTTADSDAERGSPAHEIPKAEKKPGIPSKTALQIPGTSMARSTLFRRLSPCPVPDDSSSSRPHPIAAFLIAFHQSLAVVAEPLIAAGCDSIADLARFAQLEVDTRLALLDQLHSADDSLMLDADAWSRLEGALAAVKARRWLLDASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIS4</accession>
    <name>A0A2S5BIS4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIS4"/>
    <dbReference type="STRING" id="741276.A0A2S5BIS4"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="79682" checksum="AC33F2D9EFDD2602" modified="2018-07-18" version="1">MAGSDVPELAMPSPVRTLCGTGPLADQLRQNLSLHASPEPESSTGLSLMESLPPELIEAVGHAVCRLTPFGPPSELRSLLVLSHRFYDVLGPSNAGFYANLFKERFDYHSAERRWAQMYRVEQRREKRDLLESLPEVKPDIALRLDPDVSITRPASPSQEFPDSKSPWRPLTNRDYAIEFKRRCTVLTRMRSAAESGQIPPSSSRPSSPRLQAFTPQAGKTKLQEPDELTQNLWTCFLMLLENDGKNLPHLKEYAHLHAYMRLFYDHSLLPEALKPGWPRQTAGRALGLWIGWLGGDDLSTETPLESDQRFFVLKPYVFAAHKFDAFPAPWTIPSLPVTHEEYPIRPPPEGPFFADLRPRSNAQLITHMGRRVEMAPPNLAQAAIFSFFHRVEQDPAAQSDLLTHAQGTPAQHMLGVPQSATGSGGLTASSRPTKTPLPELESRLHDRDFIRAASCIDPYSSLGLPKLYMRGSLTGSWEGRFSFFDFDSYRDMLGGRMRSLYEGPFGDQPQVWKLEERIVRLERGARPGGKGSPLNAGFEVGEGIDTGSSRSTRGPSQATSVASGSAPNSAASSSSGSSYPRLERSTSRRRTSMDLGPESNSTGRASKRAKSWSDVNAALRETDEDDWSGVDSDGDYEILLTGTGHSAWGQFVLKGRVRAWDGMFSIIKEYTPDTRGRWVYRGMLVGGNLVGRWRDTHTPTDMNGYEGTWLMTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIT2</accession>
    <name>A0A2S5BIT2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Shugoshin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIT2"/>
    <dbReference type="STRING" id="741276.A0A2S5BIT2"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin C-terminal" evidence="5">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="695"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="731" mass="77744" checksum="430A7B238E4D109F" modified="2018-07-18" version="1">MTTTRRLSSLQGQGQGQSHQQTSLWLDSYETFKRKHIQQNKEIISKNSELNKEKADLQSQISLMRVERLSLMSSNLKLSIQLEAVRKRLERALERERDLVRERDRLKLQHRVGPAVDPQQVEVMQQALVNAIAALQAFGLALPAPTSASSPLRSSTSAKASASHLPSSPPASPPPASSDFDFEPEPSSSGGSASRRASLAERGPRQSICVSPPDLSNIDEADASDEKRDDQLQRRFEPILQQLPSLVRAPSSPPRTVAPPTPSTSTATATATHAATPLARPASRGPRAPPKAPSASSHSTLGNASTTKRPARRVSGMLKPSLVVEFGEDDGGVAEEESALVGAMSRQQVDDSDDSADEELEESAVVASMPPTKSRSRRRVSSIGLDAAPTPLFASRTRVTRSTSPAAAESEEAAPIPLRQAESDSARPALRETQPKATSPSSSSCSGDPINAASTTVPPTAKEKIVERMKRRTTRVPAMATAAEVEAEAEAAQQERSSAVLASLSRGVKAGRRRVNDELDQGGEEEEDAQEQVVAGETDGQPAGAESEEPQQSDSQHESGDAREELAARNTAAEAAEEEAAAGGRRARKSVNYALPKLNTKMRRPEDYVPVKPGASKPRKSSRPTSTAPRTSEVPPPVPATSATESAPAPAPIPRPASLAGKRPPPPDSLVRPAQGDDAAARGNAPNPSTSTIRQDLEARRKQRQAERDQLAKLGSSGGDLASRRPVTATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIT3</accession>
    <name>A0A2S5BIT3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIT3"/>
    <dbReference type="STRING" id="741276.A0A2S5BIT3"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="472"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="535" mass="57141" checksum="669123484A093833" modified="2018-07-18" version="1">MPPKRPATTFTSDQPTDRAAAAAAVQTGGKRTRFAPNNAEVVAEQGVDDLELDLEQGGGGAAKKKNRVTTEGYDSDSSAGSDTEGGFGGAGGGRAGRGGGAGGQAAEPEHDEEEDDDMFGGSGTAKDSGLDVKGKKKEKEFLEMGDIEGQEFSKRDDEEAGSDGDDDDDDEIEEDYLPEDDEANADEAPRGRRSKKGMGYKLSSFNMKEELDEGRFTADGTYTANAKDPLEDHDVWLSGLSKRSIREAREAKERMDAKQREREAEEARSEEQLTQLRDDCMIGLLGLVRPGETPAKALTRLGKAKKRADELAASKEPKTAAAAAASKGKGKGKADGDNDAMDLDEGDPAAASAASTGSSALTPSQRYNKKIDRLTHYASTLLSSHGELEIYDQSYEDIIKTLKAEGAVRRDWVPPTDPDLALEEQEERAHAKAQAEADAAASAAENGKSGGRSRVVIARPTASSTAASTAPSTQYFYKWRSPPPGQPADQEYGPYDRATLEGWIAGGYFGGPEADRIFVRTDGGAQSYRSWQEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ06</accession>
    <name>A0A2S5BJ06_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ06"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ06"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="144"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="485"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="61912" checksum="1A3F599557209C05" modified="2018-07-18" version="1">MSDATTTPQSVNDAVLTQVEFYLSNSNLPFDKFLFNLWAASHHDPAAIIANSPAPEGSDKHPQSPHNAFHLGWLPLEKLASFKRMQPYLEAPPAGLGSVDAIAEVIKSSNLVEVHKFGNDGETGAGWYVRRKSPLSKPEDAMQRSVYVKGFPATEKDGETDDERKEIKAKEDELQKRLEAWARDLNVGKVLSLRMRREDKPGVEGKPALKGKGKFKGSIFMEFAEKESVDKFLALDPKPTFEGADLETKTKLDYVEEKRKLYAPDSAPITGASKDSIPKNPYSKSSKPFNAWAEKLVGEQGFPVKPSAVAAARTNNKKRGAEDDGDAEERDVLYDGVRFKARRTGGKDGKVEIVDEDNLGKGEKGWSTGKVLRFTIAKKDGSTSTDSKEDGEKFDFASLKKRLEPVGKPGFVSLLDDRPIAPLPSGDKDSAMKDAKPEFPTRLNAPPEIKSAADVKKDEPAPEASTSSSGAQQYPARGQASFREALTDEKFEQLKSEVGEIDGRKVEWVRVSESDERAHQLSRARYHAEQAFGQERGARNGGRGGGRGGARGGRGGRGGKRPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ59</accession>
    <name>A0A2S5BJ59_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0063</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ59"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ59"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="124"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="727" mass="79484" checksum="A5F4FADEEFF01D44" modified="2018-07-18" version="1">MLADRARALVRAARTAPVSRQATLGTSKRLSLLSGATLQTSNRDQLASQWLPRSNGSTTTWTYAFSNSARSAQSAAAAKVQTCRLTHRATSAFVHNVSAHRRRGAVDSQPPDRELPQLGAFPPERIRNFGVLAHIDSGKSTLSDRMLEMTGTIRKPVADPNRLATEEAKNEQVLDTLKVERERGITVRAQSATMIYTKAANDSYLLNLVDTPGHVDFSSELLRSLLSCQGAVLLVDAGQGIQAQTLSVLDEALSRGLTVVGAVNKWDLVKDDGRGEAAVQELSDLLGCDPSEILRISAKTGWGVESVLEAIVERIPPPPPIPSEGENLRALAFDSWYDSFRGVVSLVSIHEGELRKGDSITSTTTGKSYPVLDIGILSPGELSIATHLDPDSRVLRKGMVGWFVCGMKDPKEAFLGDTFHLTTAPMPPLETFKPLKPMVYAGIYPLDPGGFGKLEDAIRRLTLTDRSVTVNRESSSFLGQGFRLGFNGSLHMDVFRQRLEDEFDEEVIVTRPLVPVKIIYKDGTEKTIDNPADFPDPGGLLKVTQVMEPMIRATIVAPDEYMGAIMSLCTAHRGIPISQTYLSTGSTSSASTALKPRVSLIFSLPLSSIITTFHSNLKSISSGFASFDYEEAPYEVSDLVRMNILVSGQKIDALCTVVHRSQVQKEGRDWAARLREAIPRQQHEVVIQAAVGTNILARERIAPFRKMKLLSKQKVGKARLKERNMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJC0</accession>
    <name>A0A2S5BJC0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquinol-cytochrome C reductase hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJC0"/>
    <dbReference type="STRING" id="741276.A0A2S5BJC0"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="10">
        <location>
            <begin position="94"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="159" mass="17198" checksum="1F847774FACF7C2E" modified="2018-07-18" version="1">MFGALFDSLFSSTQALECEAPGVHAGENPSSQSDTPTDIISDPEQAREHKQALGDKIDDAKSNSGAQPTSDDTAGEDDAAPEQDEEEEEEEVPDQGEQIREACGQTKACKTFLHHLEECGERLADGKTIVPGETCVEELFHYMHCVDECAAPKIFAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZG4</accession>
    <name>A0A2S5AZG4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YVC1 N-terminal linker helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_7085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000169">
        <property type="protein sequence ID" value="POY69905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZG4"/>
    <dbReference type="STRING" id="741276.A0A2S5AZG4"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY69905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="278" mass="31581" checksum="D1F598C62778538E" modified="2018-07-18" version="1" fragment="single">MPGEGARQLLLQGGDVEDPAASACESFDEHHGHHFHPQTVTRIITRIQALALELLPIEVDLDEIRSPTSSIITSDVVDAFGQIAGDFAPAVPFALLEARRFFARQAASNPADSDENHCRKVACEAIARRIVHRTPMHEQYALLSKRFTRIESDGDESMPASALETAIDQRATFFLSSNEAQRCVFAVWRGLLVQDQQENGNIEYQLFKIKPEQQSFWWHFDPQRIAVPRYQFFFRVGLWIVFLVCYTLAIQTPDRGFGPEDIILYLQLLGYLVEDFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZG6</accession>
    <name>A0A2S5AZG6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_7061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZG6"/>
    <dbReference type="STRING" id="741276.A0A2S5AZG6"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY69929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="915" mass="99339" checksum="2CFAEE877E6AC723" modified="2018-07-18" version="1">MAATTTATPKATAYPRAQPVKRSKAPATMPIATSSAPPLSSAARGKRPRASEGAGETDKDRPRRVKSSRGQKRADVTGAVVDDAEPKAENGSTVTATAQGTEGGGAYRRVMFTSFIKQAFEKRAKGDNEEYNQIIVQFRALLPSATASAAASTSSGQPTATPLSQLRSWLEALTSVVSKLDQSHAPLVETILSIPWAITEEAFTAAYMRFVGALVSARTEWLKVVLEKCVKGFKYRSTYTQSSPHALPHLTRRLIYSRLHSLLRLLLSLVPTLSPSLSPLLALHFPSKRESRAAQICYIDNLLHLTEYCSALSEDVLTLVVERALNIDVEIQGEPEDWEEVEEEMLAAEAAKAPNGKAHAPETAVHDLVDRPMEEESDDSDSDDDDDDDAEDGGLDLDNLSSDDDEPDPINDDDAEKKAAAGQRGMTEAAIRKVLDNRAKLDGILKVVLDHLAIAHSDPSHLDKRDRTAQPTVANPFDTAFADPVVVKEESGSRETTPTAGDVPNIDTVERRMTLFRTFLDIFDRTLLRTFKTRNVQFVLFYLCSLDTASSDHFIGVLLGRALFDSDAPSVTRVAAAGYVASFIARAKYVDATMTRKVVRHLCGYLEGQMEDFARATALATSIAGSRSIAASGGQELPVFYAVAQAVFYIFCFRWKDLLEEEDADDETALFGLDAGRRWMMGLETVKKAVNSSFNPLKVCAQPVVTQFASIAHKTSFMYCYSILDSNRRSGSYRDANPNVVPTSAAVPPPPLRTVSTSSLLNTLTAAQLHLSTPSPAGTPAPQTVPAAAPRQLLVAEEMDSFFPFDPFKLPLSSAYIDPIYREWEGADDDESTTSGDHSSSVDSDEEDTESESDATAGESDADEPAWVKTRGGLAVPGSVTSPASPEDEEFSRSFEAMSLSLSPHSESFGGRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZJ3</accession>
    <name>A0A2S5AZJ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_7007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZJ3"/>
    <dbReference type="STRING" id="741276.A0A2S5AZJ3"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="149"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="151"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="279"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="337"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="390"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="594"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="655"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="695"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY69963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="723" mass="77397" checksum="D0D3B26178907A8E" modified="2018-07-18" version="1">MSSSIASAAPSKGVRRSSRASIVPPPVKSPQNPTPRKAKPPAKKKGRTSTASRGKRGDDDSGSSEEEEDEDDDRSRKRKTPKKATNGTTSKAARSREIKPKPRRVPVAGLNPVPELFSLFPSHASFSDAVRSQLDPIPDPHAGDEPAERAIFVFGTGDMGQNGLGVDDPKALDEIKRPRRHIGFAKMVEQGREGWQAGVADLVCGGMHTLAVDGKGKVWSWGINDNAALGRVTSKPDVTSEELEATPMQVEQLGSDREPFNAVRVAAGDSVSLAISDRGELRAWGSFRAAEGLLGFDGSAGSSKTQLVPQALKNVDKHTIVQVACGDDHFLALTSTGMVFACGNGEQSQLGRKIIQRHKEHGLTPERLALKNIVLVGTGSYHSFAVDKDGEVFAWGLNSFHQTGVDEDDGGWEDVISTPTRVASLSPKVLPDHARVVQVCGGAHHSLFLLSNGDVYVCGRSDGHEIGLADDHEQMVESKKRKDDAKAERAEREKQELAGFHGEDGQITATTEDGKTMTAEEAALAAAEAAAKGVPLPNDYVPVPTRLPFPKEPKAWEKDARADDLDDDDVSTEETKIVQIAAGTRHNFAVSARGYVYSWGVGPSSQLGQGDEEEVETPTRILNTALSNVRVLRAETGGQHSALVGIDREYQAKAAERREKREGAAAAAAKAEQEKADEKETNGVQPNGDAAAGDKEEEEDARMDGAEEVAGEEGKKLEPVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZK8</accession>
    <name>A0A2S5AZK8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_7077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZK8"/>
    <dbReference type="STRING" id="741276.A0A2S5AZK8"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY69945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="45210" checksum="EE444318ED8E2C6F" modified="2018-07-18" version="1">MSTTDDDNDPLPPAYLDPEGFLHDPAFHRTTTYGRDSPDGPLVVSYAVAGSVDLNAPVLVWINGMGGHRLAACLLDGICTANGVRLITVDRPAAGKSTAVPLVDRVRLSHEALLAVLAKENVKHFSIISHSNGVIYTLYTLLNLPEGLTVPAWILSSPWVPPFLSGSTLLSIASWIPSPLTSRLGGFVSGLQRVLGPLDAGVGWSSGVVRGVTEWSSGYVSMGTSAPAPAGGTAPTPAASTTADPASEAPENLPPLKQRERFRRNNAKRPPHKQMFGGEYVPPGLFGEGMKIATAEGLQSMGAEAMLCLRQGDGANWGWDDVNAPKDEMKLYERGFGRLETACRARGQSSPLDVSVWYGTEDALIPAKGREYLRTLLCETLGLVKPDDWHEIKAAGHDDTLGLTCMVEPVLKRVVEAQSRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZT4</accession>
    <name>A0A2S5AZT4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_7091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000169">
        <property type="protein sequence ID" value="POY69911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZT4"/>
    <dbReference type="OrthoDB" id="10523511at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY69911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="173" mass="18411" checksum="3AF3CACE97F3829F" modified="2018-07-18" version="1">MANKNLKAAGEQAQLVPNAAPPPYSELPAQNGASSSRGQPQLGVAPQQPDPHHQRYPSGPTAFSALPPPGPALHARADSQYAYLSARAAARQADRRAARRLCGAVVWAVVLWTIMGAILGGVIGGEVARRSEHGRSRWEEGRYAVAKLRKNFKIRKSGNATTATPVIAEYATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B079</accession>
    <name>A0A2S5B079_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B079"/>
    <dbReference type="STRING" id="741276.A0A2S5B079"/>
    <dbReference type="OrthoDB" id="2529692at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015709221" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="64366" checksum="4DC9A9F4DF02A1E1" modified="2018-07-18" version="1">MRPPTLASSLAFSTLLHIRLALARTTFYDANDYRLTFDPVEAWQLDGAQGAAVRTDGVQSAFLAFAFAGEQISLYGLSASTFTVAIDGQATASIETPSPADATQSTRVYLVNGLDQTFNHSLQLIVPQNAGSLMIERIGVSYATDSNLTPALLPLSSAGSPPTKSSSTTSRSRPTAKASSEPTTANPSTEDDGPDGGVVAGAVIGSLAALAAVVFVLLLCKRRRAAQRQSEKDTYPRKHQSVASSLFGGFGRPGYPQRGSAASPLAGSHLSHPYASSGPQGWATRLARASSWKRKAERLPETRKFYGVEDPTSTTSLPKQPPPTVPLPSVPLEATREMEQRWRTAGPALSPPPSRAEHYTVQVFGQALSDYSHDGDARARGFSNDASTPPPTARTFRNPFDTASTIVSGSHESRGSLSSAEGAHIQHAKPAATGLEAIQGSPIEMVHRDATPSGRPIPARSSSARDLVSTHRAGPDGATSTSFVPDQPVTLARKPTITCADDGTAAESTAQGTSPGANKVGPPERRVRHQSSAALIEETSNATHSTEQVHPQHRRHRSGRSSGSRSLAGEEDRPGFFAARDHVPRYSGARGDPRLPAGSDAQAVEIGRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0C7</accession>
    <name>A0A2S5B0C7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0C7"/>
    <dbReference type="STRING" id="741276.A0A2S5B0C7"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="174" mass="18566" checksum="859C1A3347D5AD00" modified="2018-07-18" version="1">MPSIQHIESLPELNKVLNTNKDRLVVIDFHATWCGPCHAIAPVYEKLAGQYPSATFLKVDGKSSPPLDKAQDVARAYRVSAMPTFVFIRNERKVHEVKGANAAAIEAGVKQYSAGGASAGGDGKPFPGQGNSLGGGTPVPTEVPPAEANYLKWLVLAAVVGYWFYSARSKAQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0G1</accession>
    <name>A0A2S5B0G1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0G1"/>
    <dbReference type="STRING" id="741276.A0A2S5B0G1"/>
    <dbReference type="OrthoDB" id="2530236at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1026" mass="109259" checksum="68C6EBBE0BB34951" modified="2018-07-18" version="1">MSAPSGTGSPRTRIPPPFASTPVSSPASARRRGVTPSVMSPLSAFANSSPAHSFRSNAYPSSSRSPESVSGQSLLQLAPSTRYRAVSAAASQAGSLATTTANTIGPTKFKRSHARRRPGQPQPPPPPAMVKSANPDDVDLLALEDPDEVFKAFGVRDVRKLEQRASEAAAAKVAELRSMVGERYRDLLAAADSIVRMRTAADNLVDRIETAETGLGTAGAASDDSPSKRRHSLRSTRRPSSPGRDRSLSSSTTVAHAIQVLLSIPSLVHAKLDQADYLEAARLEDFGQLVYRELSSFEVESEVDGGVSKRRLAQMFPLIDKQAEPLAALKPLIVRRATASLQEWESEPSVVARSMAAIAMLRRVGSTQTLATLLEARSNALADLLQSPASTSKKQDTDSAAIADRLYAVLALVLRTVEAAHGVFGGASPEVVTLDGLLEALRTPGKQVSAVLLTPVIDAFANAVALQRHLPPAFLSHRPDIVPTPADLDGVQQDVAEWTRKSSVDVLSGFSGWISSMSEAKALADLRHTGRRAFSTAQPSSPSATTANEFRSQLEHAIENRLAEVYRARLDTLVARVKPSVEALLLALPDSAADLDQSVFLFESPLVFPSASLYAPSRRHQHAHTDGIADPFESFLTKVGKRVDGRSPLLDRGLSELEDEARAIRNDLTSWLGPDGLEGGADEVQMRERLRQSYVDAACESLVGVADAIAQALEDVKHDVDGSLFLGNFAFLLGESASFTKDLLLTSESRTDSSALEEWHNKLHSVQDASLNTWRDKTVHKAVSKLRESLSLAVAQSPEAMIWAWEATSGHPAADGKGTASSVPLPATPSAATLSALTSLASALRRVGLHRNHADPSIASSLLATFADEVVELAQSFAGEIESMVEPEPRLLSEVGVRVAWDLALLAALTPEEKNDAVSSLQDRFLAMAPESWRTPGRERLRLASLDYLQGAQSILGGLLPDELKQAALGSSAGRNGIVTKSTPALNKLLPLGPAMSAFATLGDLHGASAGLVKPGPRLGLLPTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0K3</accession>
    <name>A0A2S5B0K3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000127">
        <property type="protein sequence ID" value="POY70296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0K3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0K3"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="73184" checksum="C420884B8565B5FF" modified="2018-07-18" version="1">MPAPTGHATYQSLGDLLDDRASSPPPPAAAPAAPPTATRVTKHEQQTDSKDRTTWQLNQLTVGILGAQLAWTVEMAYGTPYLLSLGLTKQATSLVWMAGPLSGLIVQPVVGALSDAATASHFRRRFYILLSAALIVASTLVVAYARELAATLCSFTGLGDWDPENGNAQKHVAIAFGVVGFYVLDFSLNGLQASLRALVLDLSPGHLQSLSNAWLGRHTHLGNIIGYLFGYLDLGHSSFLSWLGGGQEGSQFRKLAVISLAVMLTTVGITCATQHERPRAGPEDDSVSVSVWKRVWRVGADVKDNFRDLPIPVRRVCYVQFCAWTAWFPFLFYSTTYVAEELYASLPKGAPIPSSDDATRSGSFALLLYSLVSLVAGTVIPFLTHLATTYPSLPSRVGPAGRWLLARMTPRNAWTVGLAWYAACMVLTFFLSGLKGATAVVAISGVPWAITCWVPFALVMESINELEEDAERESTTSNAAPVPTARDYGSLSQSQSRKLPPFRVTSLRNSSYQPFAGAASPSPSPASPGRDWPTSPTSRRRLPEESEPLLSSPRSEREPKRVGGGTILGLHNMAVVMPQFFVAIVAAGIFKLTSSRSASALRMLASNTSPPEAGDGLQGQNDVVWVLRFGGLAAFVGIFVSRYLCETKSEREYREYVEYGWRDSIPPRDDDDDGSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1F9</accession>
    <name>A0A2S5B1F9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1F9"/>
    <dbReference type="STRING" id="741276.A0A2S5B1F9"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="472"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="567" mass="61562" checksum="F74449A1C1723550" modified="2018-07-18" version="1">MASSVIEDARGLAEDADLFERSLSELLSSLQQPALPHRDRLATSHRASDLVNRIVGRSAALRVALDPDNQDRHREMDALAGDPNQPGADLAEFYQRLAKVKDYHRKYPSAQNVTVGLDRPVDFAALENGDPEWLDKRFTGDEGLGRYLDLHELHDNWNNLAPPSASGQASAGGWKRYSYLQYLAALTDFNLSRQLKSSPAYASYLTDLLAYLSGFYERVFPLGDLDEVLQAADTDFAQRWEAGTVPGWAPQQSTSGGAGEENGIAEGSRKEASEGIWCAACQKSFAKDSVYQAHLTGKKHVKAAAKLAADSSSASASPSAAATAAASTSSPAPGTAPDLAALRRQKDRAIALKESLIASLVSSSSTPPGPLAQILTDTLANTERRAALTDKERAAEIEELEAREAAEAAAAAAAASARNGRSGESGGANGAAGDDDEEDEARIYNPLKLPLGWDGKPIPYWLYKLHGLGTEYKCEICSDYVYQGRKNFERHFQESRHAFGMRALGLPNTKHFHEITKIEDAIALAEKLKQEGRAELSHAETTEELEDDEGNVYNRKTYEDLKRQGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1I8</accession>
    <name>A0A2S5B1I8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1I8"/>
    <dbReference type="STRING" id="741276.A0A2S5B1I8"/>
    <dbReference type="OrthoDB" id="2507344at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="5">
        <location>
            <begin position="82"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="172"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="225" mass="24826" checksum="3565F824E8BE8066" modified="2018-07-18" version="1">MTSHFIDRFARREQEIAASLSAPARGSSSASAPHSGAIADRDTIEQKELAGVRDDDCTFCAIVAGEEPARKVSPPPGESVRVLPGVLTEVLRRSQVYEDDRCMAFFDIYSIRPGHTLLIPKSHYERVPHLPDDLSAHLGRIMPRLCRALGAALEQPDMNIVSNQGYAQVVPHVHFHLVPAPQHAGRAPRRGGLTFLEREDLDDDTADLLADKIRTELAKEVRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1V7</accession>
    <name>A0A2S5B1V7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_6178</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1V7"/>
    <dbReference type="STRING" id="741276.A0A2S5B1V7"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="9"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY70768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="382" mass="40853" checksum="940E81FECF5D7C9C" modified="2018-07-18" version="1">MASSSSSYRIVQISGDGIGPEVTKQAVRVLETFSQHSDIKFTVEEHDFGGIAIDNHQNPLPDSTLEACKQADAILLGAVGGPKWGTHPTLRPEIGLLALRKALGLYANIRPALFPAPSLVAHSPLKEHIAQGTEIVVVRELIGGIYFGDRREAVAGATEGKDAEAFDACTYSVPEVERITRLAAYLAKCSNPPLPIHSVDKANVLATSRLWRRVVQETLDKEHPDLNLDHQLVDSAAMVICSNPRKLNGIVLTENLFGDILSDETSVIPGSLGLLPSASLGGIPDGKSRIPGLYEPIHGSAPDIAGQNIANPIGTILSVALMLRYSFGREREAKVVEEAVRIVLDDEKAGGFGFRTKDLGGDKTTTQVGDKVVEVLAGLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B255</accession>
    <name>A0A2S5B255_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B255"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="204" mass="22810" checksum="FD41D1336A3C57FB" modified="2018-07-18" version="1">MSRRDTRTQPRALSEADELDLYLEKRDTWLSTEVRSSARQLILSNHASPMARLQQPVRPDAPWLQFLDGRYPLLLAYQAVERARQAEGPTSDSLDPLRKSFLHLTRELDRITIPVEYWSDRPHEALEGEGRHVRPVEGLAKLASAFAERSSSGRVDDTASAQRIMTELILQLGDPALGCDSLGCSDLDSSGQGLAGKEEDQSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B289</accession>
    <name>A0A2S5B289_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B289"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="119" mass="13475" checksum="4EC674AD13A8AEC9" modified="2018-07-18" version="1">MTLARLPSASTVLVGAVATALVSASDSSRWAGVVKKLLAILLVLNWRGLPFAWHTSFWWTIPELYLRIWRKGEVKAMAIARNPFEVKSITKGHVSCAEADYNMQRVPDSQRRSFRLFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2C3</accession>
    <name>A0A2S5B2C3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2C3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="277" mass="29974" checksum="3A18CA3EBAFBE547" modified="2018-07-18" version="1">MSTPSLARSRSGRLLKPVLPLSSIFKTTKSTSTTIRKVKAAASSSNDERDSTAKAVSLENTIYRKSGQAKADALPAFLLPQQPESPTPAPLDTSLDPNVRSALDLYNRCASGLIDSLDSHALLDLADECISKFGFRKEDLGNLVAHLCYMDASLSAAMSYTPPATPARARYDSDPFPLHFARSAADSPARRKSTATPLRPPVLHPVPNSFAQLSTPDEKDRKQDRRAGHVTGVEEHWSTWSYPSPASDLAASDDETLLNTPKLHSKMSISSLLMSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2P2</accession>
    <name>A0A2S5B2P2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2P2"/>
    <dbReference type="STRING" id="741276.A0A2S5B2P2"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42939" checksum="57C1E627C654ED86" modified="2018-07-18" version="1">MAAFFSFGSGVDVDVRLADEEERQSVEVKGEPPKGSKGDAFAGRERCPVYLDGEAVKGQVLVRVKDGKGIKHDGIKVEFVGSIGASAVQASSLALWKDDERLAELFYDRGNHYEFLSLVQELATPGEMRTAQAFDFEFKNVEKQYESYHGINVKLRYFIRVTVSRRMADVVKEKELWVHSYRMPPDIVNSIKMEVGIEDCLHIEFEYNKAKYHLKDVIVGKIYFLLVRIKIKHMELSIIRRETTGAAPNQYNESETITKFEIMDGAPVRGETIPIRLFLGGFELTPTFRDVNKKFSTRYYLNLVLIDEENRRYFKQQEITLYRNRDGVQGLPAALPQQNQLETPLATPSATQADEQPQYHSSPVQAEQRQAAPLTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B389</accession>
    <name>A0A2S5B389_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B389"/>
    <dbReference type="STRING" id="741276.A0A2S5B389"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="298" mass="31896" checksum="04957DEEC73AFBBC" modified="2018-07-18" version="1">MATPYQRVYDGPAADFTLSPAIRDKVLLPLTLVVLLSGVLRFVIAKYFDSPPKPQPPLAIREQRAITRGQLLRAHSSYLPPSGFTSLRSHLADAYNAGAYLKEPAPAEGAAVTPKPNPFEDPAAMDAMLDGLKDMMGKQAAGFVPQMATMYLVNRFFPPALLARIPFPLPVRFKDLLHRGAPLEVLTGLDASWCSGSSWYIICMFGLSPVYQLLLGDGMSANNMAAMNPMMAAAPAAGGASGAGAAAGPAPPPQMPGAPGPDYLKMFRAERENLDIVEYSWAADGVEDRLLERFGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3B7</accession>
    <name>A0A2S5B3B7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B3B7"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="6">
        <location>
            <begin position="1150"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="7">
        <location>
            <begin position="1994"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="8">
        <location>
            <begin position="3082"/>
            <end position="3189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="567"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="874"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1436"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1770"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="922"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1797"/>
            <end position="1807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3214" mass="356623" checksum="F5345D22D811EF65" modified="2018-07-18" version="1">MVLESVLAGILNRTLSAYVDNLNTSQLNVGIWSGDVKLRNLRLKKEALDKFRLPVDVKEGYLGDLTLSIPWSNLGGKPVRVLVENVYLLATPTDSSKSTPEEDAARAQAAKLEKLENAEMLSTHPAPGMSAEEEQKNQSFTASLVNKIVDNLQIEVRNIHIRYEDNLSVPGHPFSVGLTLAGFSAVSTDSEWRPTFITNPRGGVHKLATLDSLAIYFDTDSKSLAGYSLDEAIGKFTELIAREGHTPPHQFVLKPVSGQGRLVMNKKIDAHTPKTDAELLFKELGFVLDADQYRDALSMVDLFHFYIRQRDYRSFRPPIAEIEANRNRALWKFAINAIRTEVHEKHRQWSWAYFEERRNDRKAYVDFFKKKTLGSITVEESAELVDLEKRLSYRDIRLYRSIARSEMRKERIEHPLPVKVQSTTAKATSWIGSWVGWGGAAAADQHESDDPSTGLSDEQRKELYKAIEWDEKDAVANAIDYPLDTLMLRVKAKLETGSFALRTDPHGTANDLVALNFDDFRLDVAQRPENFEATLGLGGLRVTDGTCPGTRHPQVVRVKELASGTRNRLLPGGKQAKRRIPREEREADDDDGQSDSESEPEGEGEEEEDGAASLAVGEWALQQDPFFSFKFEHNPLDKRADNAIAMRLRHTEIIYHRGYVEAIFAFFKPPESQLESVGALIDVASETLEGIRKETRAGLEYALAQHKTVDIHLDLNAPIIIIPEDMTAEVCQHIVLDAGHISVESDLADQSAIDAVKAKEHEEYHEEDYKRLEELMYDKFYVKLEDAQLLMGPTLRVCLDALEKPETHSDSSLGELHILERTSLKFLAQNCILSAAPNLARLKVSGSLPTLQLNFSDRKYKSLMRMIDIAIPKFSGDGETSPSRPSIDPIAQHTSFARSRSRVPPASDDDDDDLTVRHQSDSDNDETARDDDVEGEKGDDKDEFFDTADIADGKQNVHQKSFEFSFAVDRVQASIYRSNPDPVKPDRLLVNAVLEGFQLGFELRPFDMSVDVLLRSLYLEDKMTASPTSEFRHLLTSEKLEGGHEHDLVRIRYQGVQKDSPEFQTVHEGFDKSVDVEMSTLNLVVTRSSILLLFDWVMTTFTDPTDAAAPTKPAIEDETTLAAESDASTDKLRVKVKLTSINLVLNEDGARLATLSLSAADVSVLLRSPTIKVAARLGNLSLHDDFSQAAPQELLTIQGDELADFRYETFDADDASTYPGYDTIVHLRTGSLRFTFRSEPVQRMLAFLTKFGRMKAVYDAATQAAAQRATEMQDMIPKMQYDILIKTPIVVFPRDEIDADRQVEDVIVANLGEIGLKNEIEILDGQVKTTIDFSLRQIGLESTIHHDEGPLTLPVLDDVSMDVRVTLRQSTDAAVSLDGPATVVSAQMSDVKMKLTQVQYGLLYRLSQKIPAAFQLGEDEGLDGIDDEASAMLKATPIPTPPAKDVRVSATSSSQPDGARQQADQVVDLLPELPRTAQTADGEKIALKPSLELDFTVKTVLLELYTAAATNKKSLDDASLARFSLNQTSVKYKMLASGSLEAEVTISSFTVHDTRPSHLTKFREIVPATRHSGHQFMIHYSQASGVDRSAIANVTVDSPKVIFSLDPVFALLDYFMSAFPKAVPAPLEIDPALVEADEQEIAPPAPSSGEFAWRVNVVSPTIILLEDPSKSDSEAVVLSLSQLQMSQQGTLALMAAELGMFLCRMDRPKENIRVLDDVDLILSMDSRTDGGRGVTNIELGVQPLILRVSMRDIFLINSIVNRAIELSNRSTSTSAGEEEAPAQTEAESGPGAHQRAVSKSNAIQRRNSVSAPRQAVLDAQVVVTKETLRATIDGLQLVVIGDMHDLPILDLKAGKFTAKATDWSTDLDASVMIKPFINYFNLKVSHWEPLMDPWEFAIHVTRSITTGLLSVDVSSKKRLELNITATFIELVLTTMSIMDREGDKVFKTARGSNAPFLLRNRTGYPLAFWSEATDTGSQSQRLEDGSEMPWRFDDWRRARENLAANTHNSLTVVIEGTNWDRLKHVYVDREGEHIHPLRPKVNKVTHRLLCDVKLVDNVKIVTFRSTFLVQNKSLVNAELVVLDEHGKKGSQVFKIPPGGECAVPIISAYHDRIKIRPDPGFGYAWSTESLHWQDLIKRPSRSIVCKAQKEAAFRFQAYAVHDKADPLTRIYPRIALSLRAPVEVQNLLPHDVRYRVFDKNLEHNWTSFLRAGGISPIHVAELSHLLLLSIEIQETKLGRSEFAIINTDNPEDLPVESDLVLADQGGHKLGLRIHYQKYPDAGGAFKVQFYAPYTLINKTGLPFALKTKSLFGSAKSVAGLEELSSESSKRKPSDPFMFSYPTDDRRNRSLLRVGDSSWSQPLSFETVGMTTEVVLPSATGNEEVRVGLKVEEGLGDYKLTKVITVCPRFIVKNNFGDTLRIRELGSTADVRVPTGERHHVGFLRAGQEPQCVLSLGDSGRWSAPFKLQTIGQTYVRMLTADGEERLARVDAVLDGPSIFIRVDPETGSWPFLLRNDSAYAIEFWQAEKSESTDRQTSPRRHYQLQAGTKQSYAWDFPAEDGRQLRIAAGGRERLVNPLEIGALVPFKFSEQGHSAVVSIDVRAEGATQAITFSNYVEEDSVFKLQRRNTETGSSVASSRDAGFEAVDVEVVTTFSLGLNFEGVGISLVNKKMQELVYASFRGFTASYSDSTTNTAYELGIKWIQIDNQLFGGLYPILLYPSVIPKDGKELEIRPSLQASAIVLKDESHGVTYFKYASILLQEMTVEVDEDFLFALLDFAKFSGAAQETESKLTEDPDGIPEPSATSKGGDLYFEVLHLHPIQLDLSFMRTDRVNVEQKLTSHNPLYFFINALTMALGNVNDAPVRLNALVIENARMPLPILQERLTVHYGDEFFGQLYRVLGSADFIGNPAGLFTNISSGVADFFIQPYDSIMMNGNKDLGVGIARGAGSLAKKTVFGFSDSLAKISGSIGKGLSAATLDKQYQSQRRIRQFRNRPKHALYGVTAGATSLVTSVASGFEGLATKPLEGAETGGAAGFFKGVGMGLVGAVTKPVVGVFDLANNITEGIRNTTTVFDQSGIDRVRLPRFTASDGVLRPYSEREALGQNWLKNVENGKYFNEIYVAHLDLPSSDDTLVVILTTVRILLVRVNKLKVGWDVPISDLATISLEASGITLVLRGNVPGPFLAISDQSARLWLFRHLERVVQAHNARRLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3B8</accession>
    <name>A0A2S5B3B8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5568</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3B8"/>
    <dbReference type="SMR" id="A0A2S5B3B8"/>
    <dbReference type="STRING" id="741276.A0A2S5B3B8"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="319"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="363" mass="41274" checksum="A319CA68A8998038" modified="2018-07-18" version="1">MSIEWYNNFLTKVSDPPGWTEQQEQVLIEPYTYLAAIPGKEFRSALTAAFNVWMHVAQDDLDIVKKVVGMLHTASLLSVKPVRMDDVEDDSHLRRGLPVAHKIYGIPQTINSANYVYFLAYQELQRIHPRPGEKIEEMVTQELLNLHRGQGMDLFWRENLICPTEPEYIDMVNNKTGGLFRIAIKLMMAASPESPPRNYVPLANLIGIIFQIRDDYVNLQSVEYANNKGYCEDFSEGKFSFPIVHAIRADQSNRQILNILRERPSSPGPKQYAVSYMDTKTHSFAYTREVLRSLTRQAREEIQRLGGNKGVEEILRRLEVPEPDEQHENGLDEAVKSLKGLSGVTNGVDGTVHRSSPPPPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4H3</accession>
    <name>A0A2S5B4H3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4H3"/>
    <dbReference type="STRING" id="741276.A0A2S5B4H3"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="313" mass="33037" checksum="27DD7B93A1BEB8FF" modified="2018-07-18" version="1">MLVLVIGDLHIPYRAADLPAKFKKLLVPGKIAQIVSTGNTTDSDTWDYFRSVAPDVRGVRGDCDDVRFLLSFFAPDCAVRPTFDLTRWPPSSRRAAPPLPPRHSNHPREDQPSAALPPSMVLTHGPLRIGVIHGHQVVPLGDAEMLAATARKMDVDVLISGGTHRFEAFESDGRFFLNPGSATGAFTPLWTPPTPAATPPATTGDAEASPGKAADPGSGASGEQEQVADEDEEQDSAAASSSRPQEAAGSTPPAKEGDAAATDAASGQGTEDGPTPSFALLDIQGNVVVTYVYTERDGDVSVEKMEYRKTVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4N0</accession>
    <name>A0A2S5B4N0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Lactaldehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.22" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4N0"/>
    <dbReference type="STRING" id="741276.A0A2S5B4N0"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008911">
        <property type="term" value="F:lactaldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="526" mass="57003" checksum="C2D72AC2E8D2B95A" modified="2018-07-18" version="1">MSNDLKASLTFPEGHSVDKVEFPVGLFINNEYSPAANGETIEVRSPANDKVIAHVPAGQPEDVDRAVEAAQKAYDTVWGERCPGRERGRLLMKLADLFEEHVEQLASIEAMDNGKAFNIAKGFDVMEAAGCLRYYGGWADKDHGKMIEVDETKMAFERHEPIGVVGQIIPWNFPILMFAWKLGPALACGNTIVIKIAETTPLSAFYATQLIAKVFPPGVVNVVTGYGNVVGAAISSHMKILKVAFTGSTAVGRTIMQAAAKSNLKPVTLELGGKSPNIIFEDADLEQAVSWAAFGLYFNAGQCCCAGSRIFVQESIYDKFLELLTEKIKGMKVAQPFQPDAFVGPATSKLQFDRISAHIQSGKDEGATVHLGGERHGTEGYFLQPTVFTDVKPTMKIAQEEIFGPVVVVQTFRDDSDIIAKANDTFYGLAAAVFSRDISHALSTAKRLHAGTVWVNCYNQLNSSVPFGGFKQSGIGRELGEAALANCAPDFIMIVRGPRDADRRSSPLTDTAVKSIHVNLTQPNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4T2</accession>
    <name>A0A2S5B4T2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4T2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4T2"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="37"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="237" mass="25740" checksum="A1A64DF28A13FC6B" modified="2018-07-18" version="1">MPSTCSSLRPRQEGSRLFPRPNSSILHVGMSVAAGLIRPIVICGPSGTGKSTLLKKLFIDYPDKFGFSISHTTRAPRPGESHGVSYHFVTRDDFVDLVKRDGFIEHAEFSGNMYGTSVQAVEDVKKGGKMCILDIDTQGVKLIKANHAYLNPLYVFISPPSIASLKTRLTGRGTESAESMSARLAAAVGELEYAKSGAFDVVVVNDDLERAYNVLRQVIVEGKTDEADKLPDFSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B531</accession>
    <name>A0A2S5B531_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B531"/>
    <dbReference type="STRING" id="741276.A0A2S5B531"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="58775" checksum="D5B921136F5CA129" modified="2018-07-18" version="1">MGFPSLKRAETGDTEITDTSSLDYEKATTRHREFAPVEDVIKEEDEDNVGQAQYIQSTKQAEMTPAENKAIVRRIDLFVLPLFLITQTLQYLDKTALNYAKVFGMDKAMKLTGNQFSWAASIFLREGGNEDRALPGLIQFGLLREPAAYLIGRYPAQKVLGLTCVLWGVCVISMIGCKNFATAMVNRFFLGFFEAAVTPGLSLMTGFYYTRSEAPLRQTIWYSSVGWGGMIGSLMAAGIERANAKSIAVPKWELIFIVLGAITVAWGAVLWFFLADGPSSAFWLSKEQRIHAVARVAASGVGIKSKTFKRAHVWEALMDPKAWCLTIAMFGSSVPNGILTNFSGTIIKDMGFSTFDAALLDCAGRSFQIISLLIAGVVTVYFKNTRMLMVTIGNVICVIATALLSFLPTANHWGRLISFWFINVQSVGFTLGLVMVSSNIATAPVTWLVLNSSKIDPNVSSASANEKPRYQSGAYAMMAGYVAKLAAHLVLWGIMYASNKSRDRKLGPADEKLAAAAGMEDKTESVKQNPNFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B588</accession>
    <name>A0A2S5B588_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000064">
        <property type="protein sequence ID" value="POY71943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B588"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="93" mass="10345" checksum="C984C1720F6D2C9C" modified="2018-07-18" version="1">MPEGINFARSPQPALAAPRTQHQARRKRKADLRLAQPYMPDMYASRSHESETATFPLLKPSEAYSTVASPATHLGGGPSPVVNRHFFLLEQYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5B8</accession>
    <name>A0A2S5B5B8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5B8"/>
    <dbReference type="STRING" id="741276.A0A2S5B5B8"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000846">
        <property type="entry name" value="ATP_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="3">
        <location>
            <begin position="205"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="355" mass="38862" checksum="A2A1BEB4CC7431CB" modified="2018-07-18" version="1">MSLPFQGLSQKIKTQFKAAKDSNAVVFFDSEVVELDDADTGIPFEVRYVPGLAKKPQGDGGKKSAGEEKNGDERPADPFAPPYVEELFVAEETVKEDEDDSGEAFVVLLNKFCVVPRHALLVTKNFARQTAPLSPLELFATWSIIKQLSSREKHLGFFNCGSESGASQPHKHLQFMPLSGGVVPFDEIIDAHKPQNRRSCFQLPLPYANFTALIDPPSAASSVPGYMGQRYLELLDLMIDHRRRLAEEDPSTAPDGGHVRLSELSYSLIITPTYLHLVPRRRETYTTERGHALSINALGYAGMMLVKDQESLEDVKKVGVLAILTDLGFRPVAASDTVEVDAILPTGAAPAAEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5C7</accession>
    <name>A0A2S5B5C7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_4986</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5C7"/>
    <dbReference type="STRING" id="741276.A0A2S5B5C7"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY71977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="509" mass="57284" checksum="5287B2DAB5828F3B" modified="2018-07-18" version="1">MVSASDVGKLLLLACTRPGEARSLITYKIWRDPLNKIESNPESGWDRPDMKRCWDLLDHTSRSFAAVIHELDGDLSRVVAIFYLVLRGLDTVEDDMTIPIEKKAPLLEAFYEKLDVEGWNFHESGPAEKDAILLREFQVVIAEFKRLDERYQKAIRDITRLMGQGMARYARMHAESGGKFSVDTLASFDLYCHYVAGLVGEGLSRLFSASEKESPYLGEQLTLSNSMGLMLQKTNILRDFREDVDEGRVFWPAEIWNKYVTEPEQLHAPENKEKALWALSEMTVDALTHATDALDYLALLSNQSVFNFCAIPQVMAIATLERCFMNYDVFQRNVKIRKGEAVSLIMASTNPRDVAYKFRDYARMIHAKARPNDPSFIKIAILAGRIEQWTETRYPSFIQVGMPVPSTSDDWAPGRDARIKQLPGPAPEELARRARAEQLRQHQMGKSDYTFLAMVVGGMLALAAIILAITGGSVWLLVLRENAPWNSKVVERASASAAAATAAAIRNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5U1</accession>
    <name>A0A2S5B5U1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4837</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5U1"/>
    <dbReference type="STRING" id="741276.A0A2S5B5U1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="16"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="216"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="524"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="866"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1150" mass="125510" checksum="0DE0AEA3CE119DD4" modified="2018-07-18" version="1">MQGGYLHYVTSEMPGTLIVSIYLLYRLLGPTAFVAIVILVLMTPLQGKIGTLLNRYQQQVLAASDERLALASEVIGQIRIVKFFAWEEPFLAKMDTTRRKELAALWKRGLTIVGTTFLALGAPIVVSVAVFVTHTQVFHRELPAETAFTALVLLQILRAPLEWLGEMTVHALQAHVSLCRIDECLHEQETQKYAVLAGTSSISPEMKVGFHRATFTWSDEVAARGDASVFQLRDLDLLFPPTKLSVVLGPVGSGKSTLLLSLLGETNRLAGSSFLPSPVVRSTDHDPVFLSNTTAYAAQSPWLLSASIRDNIVFGARYNGQRYRAVLGACALMPDLAQLELGDETEVGEKGTVLSGGQKARVSLARAVYSSAKVVLLDDVLSAVDSHTAQHLVEGCLRGPLMRGRTCILVTHAVDLCLPIADFVVSLEHGRVTRAGPPAQAEMTTVQSLQSKKAEADIADPDLSGSEADDQLSSTDRHRRMIELKLIKDETAAEGSVNREVYKTYLNAFGGWAVLVTVLGVYGAAQIAEIAVTLTLRYWASSFDEQREASTTELVRRSQQVFASVVGDDPRFSMLTEGRAGRSPNFWLGMYGLAAVVNVVLVNARGAFYKAVYWRGLKASTTLYDQLISRLMTAPIRFFDSTPSGRILNRLSRDVQVIDENIPTSGMYWTYEVLATLGILIVIFLNLPAFLLAGVVIAVAYVFLGYLYVTASRELKRLESIAKSPIFSVFGESLHGVATIRAYGDASRFMKQIFELLDDNNRPFFLYAGLAQRWLSFRVDFFGGAVALLATIFIIYSPAIDAARAGFILSFALSLQEKLLWVVRLSADLEVEANSVERVHEYLTVDQESQGGVSPPAIWPRRGGSISVNKLTASYAPELDPVLKGVSFEVRGGEKVGIVGRTGSGKSSLALSFFRFIEPSSGNITIDGLNINDLRLEDLRSRLTIVAQDAALFAGTLRFNLDPFGRYGDDEVWDALERVQMAAPGIKSLAIAQVSPDAIKATNLATFDTEASAPGDEARFVVNSLEMEVSEGGKNFSAGILKLKSSSILILDESTASLDSASDERIQQTIRAEMAGATILCIAHRLRTIIDYDKVLVLDHGVVLEYDRPLKLLANEDSAFAALCRKSGEFELLKKMAEDADVLSPSSRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5Z2</accession>
    <name>A0A2S5B5Z2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4774</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000056">
        <property type="protein sequence ID" value="POY72198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5Z2"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="139"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="270"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="39201" checksum="4B8BEB648FE58771" modified="2018-07-18" version="1">MSALESPVATPATLARDAAVAPAISPALDFCAGTIAGIASLLTGHPFDTVKVRLQTQAQPTSRVASRTGLAPPGARQHAAPYYRNAVHTFVRVTREEGVSGLYKGVMSPMLGVALMNASVFTSYKYAMNAMLATPDAEPSLWQITAAGSASGVFTSLITTPIDRLKILQQALIPTESTASALTRKQPSLLALVRSMSLPSLYRGWSATILRDIGYGPYFLTYEYVVRGGSFGLFSSREDEERNRRHVKADPKDEIDGEVFGVGEGEVGGASTVRVLVAGGLAGIVGWGCTFPIDVIKTKIQSVPPVALASSTSSSSPPTTPYTSIRATVAATLRESGWRGFVAGLGPTLVRSVPVNMVTFAVFELVVSTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B610</accession>
    <name>A0A2S5B610_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuole protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B610"/>
    <dbReference type="STRING" id="741276.A0A2S5B610"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57740" checksum="4C21A7A19BCDB999" modified="2018-07-18" version="1">MCCSSAKWKREVVPDHKFDFIDVDQFHSRTCGSRLSCVLRFPLFLPYTVELTSTGLALSFTWLWTTFIISIAVYVADIYTLVALLASNRWAGQILQTQASEDNSSNRHLLLVPFKIGKWIFFACIIVSFLLCLWDVRKARAIVKSRDISYAFTNVMAHNWYALRSYNHHCFFSQINDSKKRKDSLAFFVFFTFKGWKRLLLADAPRQVINAITLYSFGASQNWTTDLSAYFTGSFLKVTALSTMLFTVVIFVISAVCLAIAAVIYVPLLCTIQGNLKEYCCHKVDKRISELMKRKNRKRLAREADIARREARGDFSHLKDKSGRIVRAPRPQPTLPTVADHLYADPALDSAKEDAYPPYSAVPTLHRDPSYGGYGGAYAQSNGGYAGSDTDSLGGGKGGFYTHSDSVTSFDAFAGHGQQPGFAAAEPMERAPSYRTMPSQRDFHNPSQRDLLAMPPPRHVDSYRAPPRGGLYERSRMANEDQYYAGSEYELDAASEYGGRYASGDMAGRGAYGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B692</accession>
    <name>A0A2S5B692_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B692"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="250" mass="26585" checksum="B0A31753E62548EB" modified="2018-07-18" version="1">MAPTVYFVTGANRGIGFGLVEALANRSGVLVFATARDPARADRLNKLAEENKGKVVVVKLEVTSDEDAKKAAEEVKKYTDKVDVLIANAGVSTGSGPVEKVSTADLHTVIDVNVGGPLRIFQALLPLLRASSAPRVYGISSTMGSIAANLDATMPAEMTGGLYTVSKSGLNSLFARIHREHADKDKMTVVLLCPGHTQTDMGNAGAQFFGMDEAPVKLDDSIKGLLTFIDDESGKYAGKFMSFDGTERTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Q0</accession>
    <name>A0A2S5B6Q0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ethanolaminephosphotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Q0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Q0"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54592" checksum="90C48631D147A799" modified="2018-07-18" version="1">MGIYIPQSKRDRLLKYKYSSTDLSLTSKYILTPFWNKLVLFFPKTMAPNAITLLGLSLVFFNFLTLLYYNPTLSTGAKPLHVSKGGSWDPLFPPTSSEPSALAHFFTWLTGRSATHLADHGAPRWLYFTFAAGLFAYQSLDAIDGKQARRTGTSGPLGELFDHGCDALNTTLGCLLAASALNLGLSWWTIASLVATQANFYVSTWEEFHTGTLFLSAFSGPVEGILLVVGVFIVTGFKGPGFWDTGVLSLFGLHPSTNDFFASLPFHIKDLPLNDFFLCFSSVGLLFNIYAALKNIYVAMPAASRSLSSLIKPMTRLSPFVSHTLAMLAWVHAREKLLLRTTLFIPLALFWGIASAHHVQLVILAHLTKSPFPSALYHPLVLVSVTAALDAHFKVFQTSDERVKQAVLGCLAVAFVVYSHFVYEVIGDICAFYDINCLTIKRKPAPGTAGAHASPAEIAQAKGKADEPVREKNVPVAVGADPTGVKQPTPLGTLKREKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Y5</accession>
    <name>A0A2S5B6Y5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Y5"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Y5"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="6">
        <location>
            <begin position="83"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="544" mass="59009" checksum="C35284638D018F24" modified="2018-07-18" version="1">MPSVAAPLPTSKSTKRAFYGTLVHSLSLTEIEYLEDALLGVDERGTIAFLEKSVQQDQVDARLQAHGWAAGEVQVIEMQRGEFLMPGLIDTHTHAPQYLNLGYGQQYELLDWLSNLTFPAEAKFADAAHARRVYDSVVERVISAGTTTCCWYGTIHSTTKILAAICHRRGQRAFVGKCNMDRNSADYYQEESAQKSLADTEDYVKFVRARCADPEAPTPAAKQNGGTVGGKTPRRSTALVQPILTPRFAISCSDELMSGLGDMMDRDPDLPLQTHLAENPAEVDFALSLYPGIESYTAAYDRFRLLRRNTVLAHCVFLSASELDLIKARDSGISHCANSNFNLRSGTARVADMLDKGIKVSLGTDNSGGTAIGILSALRSASTASKTIIFHERDKKPETASSDDSVINTDGISRPAGFFAQSHLSVETLFYLATLGGAQVCNLEDRIGNFVVGKEFDALLVHTGQKTIASAAAANGGASIDDEIEKALASGESVLADGVDNPALMLEPDEGIERVFEKFLFTGDDRNLRAVFVRGRQIGGREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B798</accession>
    <name>A0A2S5B798_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B798"/>
    <dbReference type="STRING" id="741276.A0A2S5B798"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="104"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="233"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="316" mass="33426" checksum="DE1FD2962098F8B2" modified="2018-07-18" version="1">MPKENAHAGKSLFAGVVAGGIEGFLTYPAEYAKTVSQFQSKGNAKPAGPLTIITETVKAKGLRGIYSGCGALVAGNAAKAGVRFLTYDQIKSYLADENGRLTPERSLLAGLGAGVCEAILAVTPSETIKTKLIDDAKRAVPRYHGLVNGTVVICQTEGIAGVYRGLFPTIMKQGANSAVRFTSYSTIKQWLQDRSGTTKALSPIETFGAGAAAGVITVCPSAKASSERRLLGFGGLTFTLAPNTADATMPLDNIKTRMQSLNAATEYRNSFHCALRVAREEGALSFWRGATPRLTRLSMSGGIVFFVYEKVMAAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7A7</accession>
    <name>A0A2S5B7A7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B7A7"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="7">
        <location>
            <begin position="625"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="834"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="954"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1435"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1067"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1473"/>
            <end position="1487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1516" mass="161961" checksum="32EEDDCC5C0FA5EF" modified="2018-07-18" version="1">MDPNKTSLNVRDALSYLDRVKMTFADQTQVYDRFLTIMKDFKSQGIDTPGVIDRVSTLFRGHPSLIQGFNTFLPPGYRIECSVSNAQGEGAAGTEGGTTITVTTPMGMTTRTQLSGSAAAAAGISGEAGGDAASGTAASATDGATGAQQVKQEQQQQGGTATSGSSASSMHLGNMPAPPAGVAAMQAQAGIGAQGSTPMATTPGAATFLSSSMNTSATGGDGSATTAPAASSATASQAAPAASAPPAQQQQQQQQQQQAQAGQAARPPMEFNHAINYVNKIKNRFIREPETYKAFLEILQTYQKEGRAIQDVYAQVTTLFHSAPDLLDEFKQFLPDTSAEGQAAAAAAQAAPSQAARTQQSASNANASKRAAPPPAAAPATAPPSKRAKTGSGKDAGFAATGKSKGKRKATDTPLAGGRVPKGASPADAMYHSDSPSVAGDPQQQAAAAAAAYYYGGAPPMPAVPQQQHVASGQYGLPAGVGGPAPVYAYEPPAPAPAPEPLLAPKPVPSQPDLAFFNRVKAHCKDQETYYEFLKLINLYTQQLIDLTALIARAWLFLHQDDSLWTDFKDLVGWVHAEPYVEGVLGDPGHRVELDSLGRRVVENVPREDGPRWRKSHGDAGKWWETYGPSYRRLPPSEISLNCSGRDALCWEVLNDEWVSQPTWHSDEGFVDKYKNPYEAALHRTEEERHEYDYHIEANLRTVALLEPIATRIALMEADERVSFRLKPGLGNQSKSIYQRVIKKVYGKEQGLEVIQALHENPCVAVPIVLARLKQKDEEWKRAYREWNRVWRESDAKNFLRALDNQGFAIKANDKRFLNTKALVSEIESLRREQNQRAFGSPDHPKPRGHHLSYPVTDRQAIYDATRLILSFLDRTYIVSFADKPKVDAFLQEFFAMVFAMSPEELAREVNVLSSEEDEAASATDGASDAGTHSGTPAFEDALEAALNATAGAGASGLPVGSRKGKKGGDLRKKALRKTVGQESVPAGTGRARKRTAAGPSAMANIGASVGASGSAPNSRAGSPIGAAGSGAEGDSVMADGQAVASGLEDTPGPEDGGSATGASREATPLDAPADQADAPEPAAVTEDELPEVIIPVDAKPRPKTDRRKAYNVFANSTLYCMLRLFQVLQQRLTQLRNAASVLAVPATPQPITPTHVPSLSPSLSYAPPKGAGWPESSDFYYRRALAICEKMFEGAIDQAAFEEALRRVMATNGYLLFTVDRTLTSILKLSLTAVTDSKTRELYGLLQEDRSHSDRGTHSQQIAYRTQAEAILGSDDNLYRVEFAPADEQENSAQEALLGYMRFQLVGKDVIGPEDLGAAEREWAEYVANYVRLERTPGLAVEPRVPYLARNLRQLGIPPPPTVAAAADIRPAVPKGLKIVSGLQSKICLRSYKLFFCAESEDLLVRTGRSGPEEAVERDLRDKKATRVSRWLDKRRKELEAQPPATNAGASDKLGSATESKAEEVAPAVKGDAAPSEPVAAASADVKPAPVEEDGDKKKQTSAPATNGGDVEMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7F2</accession>
    <name>A0A2S5B7F2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B7F2"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="804"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1195"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1523"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1562"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="627"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1133"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1581"/>
            <end position="1608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1616" mass="173160" checksum="1C4D31436FFE1CD9" modified="2018-07-18" version="1">MQSQVGQPAGPAAAAGAGPAPNPSAGSPPAPTASTSTGSTPQPAPRTGLAAQGTAPQKQPSPVNPPSQQPPAAAAATTATQAPLNVRDALQYLDRVKTQFANDYDVYDQFLTIMKDFKTQTIDTPGVIDRVSTLFRDHPSLIQGFNTFLPPGYRIECHVVPANGAGSAAGSGAGKTNTITVTTPMGVTTRTQNVATGSIVSRASPSAPGGGNKQQQPPPPPAHAGPGGAPSVLQRPPGPIPSASAPSIGAAPVTATSATSHLPGSRLPPLPTQQQGPPAPSSSSGGPTRAISPPAPIPPFGGARSAPWAQQMQQQQQQRATGSSAPGTGRQPGGGPLSGAGPNSGNGAAKPAGSGGNFGQPKPTDANAQGRPLHGYGSGGQQQQQSGGPAAALSTPAPSHTGGAGSAATSAAEPTPSSTPSQAQGAPAPAQPQPQMMEFNHAITYVNKIKNRFAKDPETYKTFLEILQTYQKDQRPIQEVYTQVTALFKDAPDLLDEFKAFLPDTSGQAEIGVVPGAQGGTATAGAGGAAGAGAAASASKKKDLGPSRSSSQVPVGHSAPAKSSALAQQQQQQAQQAQQQQQQQQQYTTSTGEKKKRAAPGTSDKAKAKRAKMQHLQTGAGSDASPQQRAHAQQQQQQQHATEQYVQQQQQQQQQQQLTPVSPYGPPPLGPQHGHPHPYAAAPPGFPGAPRLQSAYDSYLTQHHNPTLVQPDEFSFFDRVKKHLDDREAYTEFLKLLNLFTQEIIDLKTLVSKSLLFFGNDELLVAQFKELVGWDPVSDGRAEGEDWVIDNESFLDRPRVELHLLKSFGPSYRKLPDSEVDLACSGRGPLEWSVLNDEWVAFATWASEGSGAHRKNPYEEALYNSEQERHWYSFHITSMARTIAYLEPIAARLALMPSEERATFKLHGEDGLGAGLGGTAPSVYDRIIRKIYGKDHGWEILQALEDNPGVAVPVVLARLKQKDDEWKRAEREWNKVWREVDAKNYYRALDHQAIPFKALDKKLTTTSKSLTGEIESLRTKKQVKRFDIPGVNHQVHPSQPSGAVTYPTDAISPSLPPPLRPLHQFELHMTDRSVLFDVLKLTISYLDRDQTNYSAPERARVENFLRLFVPLLWGVPAEEMETNLGPSQHADSLEAELEADTDADAGTETESAADGEGSEDGASSSTSQRKVAGKRGAADLRKRLLVHAAATIGRAGGSNAVNGKPGSRAASPSEGDSELGKLADALWIRLTETKADGEPVEPASPDILIEPRRYSFFANSTFYCLVRVMHVMYHRLLAFKQVATKLATEHAQSRLNPLSVELGLSAPVPSIDVDGNAAEHYYEHMLDLAEKLFDGDIDASTFEEQLRYMIGIRAYPLFTIDKLVGTAIKHIHTINSDGRCQDIFTLLERDRARDTTTPRQQIAYRMEVEQILHQDENLYRLEWIPNTQAMTIQLLGKEDLTLDDAHGSDVKLHQSWLASYVLVSPSEGIGAPVKAPLLKRNRSVSSTEEPPAFEIVPGLEAKVDERGYKLRFVAGTEDCLYRRSSTASDDDEEESNTRGAIGQRRKDRFERWLHLQLHPEEAAEAQEGTEAEPTGQDDVVEGAAAQDAGAGSADGNAAAASPEGAGAQHDVDMRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7F4</accession>
    <name>A0A2S5B7F4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4528</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7F4"/>
    <dbReference type="STRING" id="741276.A0A2S5B7F4"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="166"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="481" mass="53028" checksum="E955CCB6EC3B4FA0" modified="2018-07-18" version="1">MAAVAPAEQNGSASSAEMSDVKLASANAAPAAAAEPNGNDEQHDDDDGEDDDEAAGPANGTSDKKKSKSAVLSSSRHRRDYWEWHPDSALRASIEKKKSNKKKKKVVQTEPPTVPVSKFFKDGQFPVGQTHDYLGDNSYRTTSEEMREKERLLMQEDESSPHNYNAIRRAAEVHRQVRKYARANIKPGMQMTDIAEMIENGTRALVEENGMKSGIGFPTGLSRNHCAAHWTPNAGDKTVLQKEDVLKVDFGVHVNGRIVDSAFTLNWEPTYDNLLKAVQEATEAGVREAGIDVRMGTIGAAIQEVMESYEVEVGGKTHQVKSIRNLTGHSIDPYIIHAGKSVPIVASYDPDDEEAGEKMEEGEYFAIETFGSTGRGYVQGGGECSHYARMAGVRAPLRHDSSKRLLASIDKNFGTLPWCKRYLDRTGEKSYALALRELVMAGIVQDYPPLYDEEGSQTAQYEHTIILRPTCKEVVTRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7U3</accession>
    <name>A0A2S5B7U3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7U3"/>
    <dbReference type="STRING" id="741276.A0A2S5B7U3"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="113"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="538" mass="59749" checksum="1899985289E5D29C" modified="2018-07-18" version="1">MVTFALTLKHAGKSYTLPDFDPSAPAAVFKDQIYRLTGVPTDKVKVPVKGGMLKDDADLNKLAFKPGQTVMVIGPAGPIPQAPSKPVVFMEDMSEVELAQSAKYPVGLQNLGTNLRAHPWGNTCYMNSTVQVLRAIPELQNALNSAQGQASVPDAQLTRQLRDLYQSMNRTTDAFPPLTFLNMLRQFAPQFAERSRQTGQYAQQDAQEAWGAILQAAKSSSLTTEGGNFVEKALMGEYEKTLKSTEAPDEEPTVSKEQFLELKCNISMSTNYMMQGIAESLEQDIEKNSPTLGRQAVYHETTRVSRLPSYLTVNMVRFYWRRDINKKTKIMRRVKFPFELDATELVTDSLKQKLLPVNEKLKDVDRDRRERAKTRRKTKKRVEQQEQAARAEANGQPAPVQDPNDDPPEQVLADTPMDGELPDEETKRQEELATLLSLVHPDLEADKGANVSGLYDLAGIVSHKGASADGGHYVGWSAATPSGENGEAVYDVDPDKTEWYKFDDEKVSLVSKDKILALEGGGEDHCAYILLYKSKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7W2</accession>
    <name>A0A2S5B7W2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4111</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7W2"/>
    <dbReference type="STRING" id="741276.A0A2S5B7W2"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="538" mass="58863" checksum="60A6FD867FF71D88" modified="2018-07-18" version="1">MVAPARRSFLTRLTRNPYVAGATPTLGGLIFGCDISSMSAQWDNEVFLAKMGHPSPFRQGGITAAMPAGSFAGALLNSYLADKIGRKRCVILSGWIWVVGCIIMAVANDVRTLIAGRVIGGFAVGIASAIVTVYQAEITKPSMRGKIVSIQQLSTMSGIMIQYFVSFGFAQTAGELTFRAPFGLMAIPGALLGSLMFIFPESPRWLMDKDRNEEALQILADVHAAGDTEDALVRLEYNEIKKQIDFDRTQAARSYMDLFKPDVRLRVFLGMSDQMWSQLGGMNVMMMKAAGLQGRQAGLIASSVQYALGVAFTIPTVFLIDKLGRRPLMFGGAVSMASCLLIVGTLTAAFGHAVNGSGASNTVTWVVDGHPAVRNAIIVFSYLFVCSFASTWGPCSWTYASELTPLRVRAKAVSFATATNWTFNFVLGLTTPQAFHNLQFGVYYLYMAFNILAAIHVFFMFRETKGYSLEQIDEVFANGHPFKAWQVPKDIVPAKALQRDLEGRHVEDLQHDSRTDEKDEKGEFAHVENVMHPSSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Y5</accession>
    <name>A0A2S5B7Y5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B7Y5"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="68"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="9">
        <location>
            <begin position="1619"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1757"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2000" mass="214024" checksum="2A21A1BA0664B8BF" modified="2018-07-18" version="1">MSPTLIGGLGQLAAGTSASAVQRRPAVPSLLLPHSTSPLQQALRAKSRRTTAPVVPVQHHEEVQLVEDEAGDALSWTRDRVVWKRGGTVVRTYSYRHDAQPVTQALFVDFQARLDCAADRATDPVASTSAVTLDSPAGTTDSSAFTSPFGPYSQRNPTAWSDDPLPLPTEPPVSEKPAATATERHLVVILSTVAFAYPASGGVVPIHLPFRIERAWTLDHGMLLQTTLAGDGAASTAGQGGDPVAGSTSLYTLSSPFDELRPVAVRSEVPLPAVRTHESAAPSVLSEMAWAPCDANERVVFSSPQRHGAPAVVVTSNHATGEIALWQYDRLQETIEEGNALSPPPTSVPQQTDPRDQLANLSTIGALSPREISRQQESTFASSPMSRGPSSLSGTKRKHGVSFADPADGSAVLRDERSVRRVSAQGAAILGGEGGRRPRSSLPRNPLDQEEEMLDALAHNAEPHQSHLLRSGHHHTGANPFPTQQQHRRSQPGDRRASLTRNELSVTMDRMALSQNGIPFGLGGNGNGFAGAGADLAHEATILLGEDPRATPTCSELVLTKLWSGNAGASLSGKLAAHLFDVRGPHATLALHVNQATLVLLRLTTDPGTKRTTASHLRELPAAGCTVAASDRFPVQDLLVNRPDGTRVVLAANGLDRSAGVESIASRPAQERDDAALEPRPRPAADLCLEALAKVLPFEVFVQLRDAVSTCDTRGRELVEIERFLAGNGPPSTNGAEPIHSAGRSNGPTFSNVHNGLASLLRSSTKRAGGTGNAARSAAIAPAAGLQYEGALLALHLLAQRLLLEIGGRRPAREIGRVVANLAAAAGFAGWMDFYARNEGSSAAPVSAKIASPARIPASPPCLLGQLQAALKGQTSTSFPDIQSVASLVETTPCDYYGPRSNPTELSSRIAALYRLLASPASDPVPNRARRAVLKMAVEYEWTRDDLDQLAPHVYLPLREALRSCQIDPPSDWPPSAYTLIRRTDMARQRGQTFDRDGQVRGAPPQVTTVSIRRLGAPKRPLRISDEHATGAKARSATRFNEDRRLEEVARMLRFDAPCVISSGDRSLEQLTPQIQQSVLIALSQRTMALPVGAGMYYYRSEHVSADIDEVNISHINTAARILPMSSPIALADKDGRETPSPNTPDRMEWPDFHAGVAAALKTSFPGELLDSSTLSFNRPATLDGRHAGLLFGLGLTGHLSSMLSSQAYEYLKAKHDPTSVAILLGLAVSYLGTGDSTVTSVISIHLPALHPPNSSMLNVSGMTQAAAATSLGLLHFASGHRTFAEVLLSELCNVKVSSLEDGTLCREAYALSAGFGFGMIMLGRGRDRSVLAAHEVDHLRIFRSLILGESNHPLPGSHQSNAAIDINITSPAATIALTLMYLRSERQDVTDLLPLPDTLRALDYVRPDLLLLRVTCRSLVLWSKIEPSKTWVEGHLPSFLVSTAPPSASVTSDTEVARWHVIAGACFAIGLRHAGTASAEAHATLIHYLDRLSRASYSKTVSVQNRIRRHALRNCLAVVSLSIALVMAGTGEVNVLRRLRVAHGLYSEGVTYGSHLATHMALGLLFLGGGKFTLGNSDAAIAALLISLYPALPAISTENRAHLQAYRHLWVLAVEPRYLEARDVETNDLVFLPVRLRLHDESAVPATTAAGGSARSKQLVAPTLMPDVRTIEAIQIDSPRYLPFVLKLASGSAERARFLRSGTLYVKRRTGHLSYAEDPRGVRSIFTRSKSEAGSSVFDFGELSSLLSTSASGLREFVAAFSGEDEALAATNALCHPQDLSRPPTSFEAFASTVLLECLTKDKFDLAGMYHAVFASMRNLERSSTGLADSIHLDQEELEFLLDFYRAGHFKRLLSRTGPSTSSQKSGSSAAGSSREALLSPAFITHVSMAIDRVGANAVAHSTASGALGSYLRDATWPEDASSAQILSRALRSLNVPDLLALQTLRNLVASARASESLTTEAVEVLLRKVRSTLTTQGGRAEPWKSEASAILARAWCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8C9</accession>
    <name>A0A2S5B8C9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B8C9"/>
    <dbReference type="OrthoDB" id="2593174at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF48">
        <property type="entry name" value="TRANS-GOLGI NETWORK-LOCALIZED SYP41-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="536"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="606"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="748"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="797"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="936"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1488"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1085"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1489"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1520"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1563"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1595"/>
            <end position="1619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1619" mass="173762" checksum="3ABFD19EE92FDCC3" modified="2018-07-18" version="1">MLSTLSASVSGYFSRPSTSSALAVSTAPEQSDASNRSTRTRIAAPNASSDSEESPHTPEQHSGRYSPKSLSESGNQTMASVLSAHPHFSIFRKSTSLQSLDQLARRQEQQDSRGGEDDSPSAGSRLLHSRSFSAQDLRGVEGDLVETLATPPNRSPVPRTRLSDSPGVRHGGRSSSSEASFHLDSAELPSLNFGDHSSGSLGPSPVASPSLAASVNTAGEQAPVAGTPVRANASSVGQTSGIRLIPDSPPTTTRTPSRASFSRSSSAETASSSTSTSTKMRASTAKGPIERVQFSPLGLCPSPLLAAPTLPPPPPPPVLEATPPARSKDSTAPLVDFDSPSVEAALHTLNRKGSNGILKLPKTPGTGRSVRFSSSTVQRTVERWMTPEDGTNLFDGYEEQLAGAVGRPDADASPCQLVEETESVTVHAVEAETSIATGDSSALVNFSSASFLSKLQAAIPSPDCSLEATSPPPVDVVDLPTIAEMEDAVEDEAAPDGEEQAHEPPPVQPSSSKRPRARLSLLDESNPFLSLQLSALGGETLEQEPSTASVADAGALAEAESRDESEAVTSPYGAADDATLLMQGSLRGSVGAPSFGGQSFVEVSHLHNPSPVPSTGSAAHLESIQETEDSMAERTLEEQASTRTVHASASQLVSTAVPRLSGLPTSAGTPSRPSPWSLPNTTPRRPSPLTQEAEFSFVSNESGSISVSQAASTTSPLHESDFSIAASLNSVSPSVGTILDESAGSLVEIRPLEPSPPTDSQQEATSAVQTPPVPPTSFQSTSSSSFYRTFMAARAREGLSQSAKEEWDRLERGEKASPKEQDPTDSGAGDDSLALEGMSVYWSPQRTFNHDEEEGRSVYVDAGSEGSETSLVEVDPGRATFLSPIAEITEPESDVNSTGEKLPVSRTLQSRSAPPPQLSFAGALSASTGGVAMPGTPGKTAIGRLPATPRSASKIPRPRNPITPSQNPFLLQLARTTTNSEAGSLLHDLFSTQEDQLAASASQRFLLSSLVTNLQDEVEQKNAMVANLQRQVEMARAEAREIEQLALSWEQRAQQSQSADGTAPTRSSTDTKKLVALEETVRLLADELETRMREDRSRRRELEKELDRTGAELLQTAAEHRDAVIRLKHITEAQLQADAAMTTLRASEENAVRQKQEAEREREELRARWRVDAEQRDQVVAHLREELADLRAGQSRAQSDADIEREVRRQVDLAMQDSTRELELAKHDLAQRDVLLAELQEQLRVSRDDTDRLTRAVQEERQHAELASADLEGLLSAREQALERATREAAALQEELDDVTARLEAVEAERDRVTNSLESKEAEYAQQTEQTRYTLAAMAELEAAVARVERDLAVKEDELVKLRRELAAQKRESDDVLEKRDRVLAEAEREAGRLRKDLESVRGENARLTELVGKLRLDSADREVKVAKLKKRAAELEEDVFGLNIALDAKQQEASHYKRQMSHLKLDKEKANSTSQYGLPSTAARPAIAPTVSSSATSANVVNTSNRRKSHATTPFPTEKASRIRREPGATDARRLATDLSNASASHDLTLPPLHSGNEETPSRPAVARPSRRISTSASSTSLGLGLPRASSEISRSRRASEETKENDAPVRRREAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8N0</accession>
    <name>A0A2S5B8N0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3909</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8N0"/>
    <dbReference type="STRING" id="741276.A0A2S5B8N0"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="128" mass="14567" checksum="CF8BBB13F6CB8E60" modified="2018-07-18" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPALRQLASKFNCDKMICRKCYARLPPRATNCRKRSCGHSSQLRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Y4</accession>
    <name>A0A2S5B8Y4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Y4"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Y4"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000060">
        <property type="entry name" value="Related to DUG3-probable glutamine amidotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="374" mass="41379" checksum="2FE7C3D0B0C22ED4" modified="2018-07-18" version="1" fragment="single">SSHIRRLPRDLVPSCGDSDVTSYARNYRLLVVKAEQPIQLAQLLTKPAHSIINQASDSRLRLDAGSINADGFGVGWYPTERDDDAGSPGPCVFRSITPAWSNANLHRLADKIKSPLVFAHVRASTTGALSEENTHPWTYGNLIWMHNGCISDFSRIKRRLQAELSDAYFAVPQGNTDSEWAFACFLEQLSRLTDPLQPTIPHAILREAMLNTVQLLTKYTNDVGASDPSLLNFCVSDGSSVVATRYITSATEEAASLFFSTGSTFEEYAPGSFKMNKADKRERIILIASEPLTFERADWVEIPSQSCIVITPRNNLLRFPIRNEFFQASVTSHRRDEFARAKGYRWTTAPVSIPGPNAVPQSTASVATQVVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B902</accession>
    <name>A0A2S5B902_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B902"/>
    <dbReference type="STRING" id="741276.A0A2S5B902"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="345" mass="38085" checksum="A23E22E12F548D35" modified="2018-07-18" version="1">MSFFGARPAVTVEPKDVEVPNLPTDSVSAIAFSPTADILAVASWTNEVRLYEVNAQGQAVGKAAYSHEGPVLDVCWSKDGSKLFSAGADKAARMYDLQTGQAQQVAQHDEPIRCVKYFEANGQGMLVTGSWDKTLKYWDLRSPNPVASVQLPERCYALDVVYPLMVVATAERQIQIFNLNQPTQAFKTLTSPLRWQTRTIACFPDGTGYAIGTVEGRVAIQHVDDKASASNFTFKCHRKDEPAPSKSSAVYAVNDIKFHPYGTFATAGSDGTINFWDKESKTRLKTFENKGGPIATTSFNHTGRIFAYAVTNDWSGGHMSNKPDFPNKVFLHPCKDEEVKKRQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9G7</accession>
    <name>A0A2S5B9G7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B9G7"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="875"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1316"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1492"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1672"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1767"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1797"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1545"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1673"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1712"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1821"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1835"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1856"/>
            <end position="1879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1879" mass="198089" checksum="64F13F301E46CC59" modified="2018-07-18" version="1">MPSTSRSHSRSPKPSQDDFHPDRTPRAVDFAAGTRPAPSQRESAPGTTTSGTLVRGRERTRSFLGLGFGTTTPTLSDTEGTGTSARRKISFGPLGPAQSGAGPSTSRDSLLRVASDHGEPRSSPAPPIATSTSRKSTNTAKAFIRRAKSFGTSPLLGSSTDGGFDQPAADGSSAPSSTHPSPTSPRPIPLPRTSTSSLLVTNPLDLRYGSPAAFSPTSESASLTGSGSPYGFANSRASTSSMVLPEALPVQPHWLFAPAPTGSPGASSGGRSSSERASRRRSQDAESRRMTEDVRPDVKGKGKAKASEKTQPTPKRKTRRATLGSLFGRKDSKASVGSAGEGVDAASDFAAAGTERRLCDSPQDSPVPTFPEFESEREAIPPLPSLPSLQFSRDPYRMSWGFAHLSPTSSPEKPREPRPRVAISTSVSNGSPGPSSPVVALTRAEEAVDADKTIILLPAQGQDGRPLPPPPPPILQHAQSTDSAQTLQARRTSTATALDALETAREELRASTPPGLRQRSNSYGFPNPTSPRSMYPASSSSSIPVTPSPLASPVGELENPLSAAPPSVPAPVPSVPSAGFAKSLIKTRTARSHSDASDRRSPPNFAASTGGASFSHSLSSSGATLPAMPRTSSSRPTTADALTTSTRSSVFGSIGSFFGGGGGGGGGGAGSAPMSRSGSTSTSIGIASTPSASPSLIDGMRGTNEFGALFDSAERRSSSLARPSSSRKRGLSVGAGVGFGLFGASSSSASLGVPPPASTASTSSISGRGRSGSTSSVNTSASGAGSGPLSDAMASLVVPPSSLGSSLGGRMRALTDPNRRFSFGIPGGGSETPGGSPARATNRPRGSSLSAVPQSQPLLPPPPKKVRRAPKPRQDESPEDYVRRLLEGSPAKSSPEGLGLRPDERASSDVTEDDELVPRGELTQVLSARRSHVPSSPAAGAPSPSPEPFFAQALRAFLRLFPFQGLALDIALRVFLGSAALPTETQHIDRVMEAFARRYCECNPNVFGGIAKKRDVGEEGVSTEGTEESRTVEGAKRDGQEESDIPYVLAFSMVMLNTDHFNPNAKTKMCVSKGLRRIAQSRTNAVVPNRTKSDYLRNTRIDGVAPEILEYLFDQITLAPFVYVDDRNRAAEFALRIPSSQAPLNASIGPSTSSSSFMSATGSVNGAGHYSSSGANKGKVDPYQLIASGQTARYRVDVETQVPSKSPFSFMGTTSFFSGAVKGLNIDEQDMTSLHALFAHAPVLQIANRSRATSRSQVGPDLASPGAFAASSSVDPVTVESPNPLVFGSPLLPTNSNSTFVEPPKKRDRPLISTLKITKVGLLSRKEDLAEGGKKAQSRKWRGWSVVLTGSQLLFFVRRIELADPSTAPGCLADESSLSQKDAHFASNLQSALDRAIVSAEPRPPGHVLAFSYPGSFKPDAVLSLAHSVAIYDSSYAKYRNVFRLTVPAGRQYLFQAHDAEELNSWVHAINYAASFKSAGLKIRPLASTPVLARPQRSTTPPIPAEQPSRMASSEAGPPVHSQAHESLPGPEEQRRAAPSVPDARLSSESRLSSNISDAQVTLSRIVGPAGPDPSSDAPFNVRAQTLRAKIAELDALIRSTKENLQADLRLARHLALLTPFRTSTRERILSSIPPIEKRVRHLRMQLAKHTGYREVLLRDLLAEDRESERLMRQHSLHRTHSRRTSSVPRQRSGATLARESGLKVPNGAPKLGRSGSSRLRPSSLSPADADADASPRNSFESAAESLSAFDDAHELAQHSLTDDELDRLHVKAAPPMQRSKTETDWVRTAVLDRSLLRPASDGAPEQPEMLRAPVSGYISGEDELEEEAAGIDLPGRRSSESRRPDEDQSVGSPSPTLPSPRPSPSDAHLPPPVPPIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9T1</accession>
    <name>A0A2S5B9T1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9T1"/>
    <dbReference type="STRING" id="741276.A0A2S5B9T1"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="41"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="133" mass="15078" checksum="8F3171BC6D54458B" modified="2018-07-18" version="1">MSSAYRQGGLLHRDPNRTALFGNRSSSPLPMYNKPQDRTAENIEGQNDEALEGLSQKVKLLKNITINIGNEVRDSTKMMNGMNDTFGSTGAFLSGTMTKMKKMARRQGGQWCLWMIFLGIVVTIFCWTWLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA21</accession>
    <name>A0A2S5BA21_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pantothenate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA21"/>
    <dbReference type="STRING" id="741276.A0A2S5BA21"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="591"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="68624" checksum="5C11F86384E5183C" modified="2018-07-18" version="1">MEDSQLPSPAGTQLLVDVRGAEIVSSASEDPEVYLPHHEEMISHIAIDIGGSLAKVVYFTRTAPSSSRSHGANGFASPPSSADLSSDSATQSDLASPQPSTSNDPSQWEPRRTPSPPQHAKPNGFLGPKSLAQEQRPSSRTRPTSSRALQSHLRRRSSTSRIPSGGRLNFVKFETSDLSSLISYLESLISSSAQANRVPLDVMKRNVKIMATGGGAHKFYQDLHAALGIEVRREEEMECLVLGLSFVMEIPNEVFWYSDELIQAVSHPQQRALSAVTIPSTPGSSATPLPLLPSEFDDLMDAPAPPILRQPPATGGGKALGSITTSAKSTPGHSARSSVSSLAVPSASDGASAAAPPLVSPSAEDLPRPSPNPPQYSLKFDSSPTPAQFPCLLVNIGSGVSIVKIDDYGKFERISGTSLGGGTLWGLLSLLTGAKSFDDMLALADRGDNSSVDMLVGDIYGQDYQKIGLKSSTIASSFGKVFRRGEGHGDAPGPEEEEERRRSFKAEDISRSLLYAISNNIGQIAYMNAEKHNLDRIYFGGGFIRGHAATISTLSYAIRFWSKGTKRALFLRHEGYLGGIGAWLKNIGAGPSPTTANGETQTKRIPNGLTQAQAPEGEIGVEEEEDERRSRVDGVPGATPASVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA80</accession>
    <name>A0A2S5BA80_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA80"/>
    <dbReference type="STRING" id="741276.A0A2S5BA80"/>
    <dbReference type="OrthoDB" id="2525720at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="948" mass="102222" checksum="0062D51F40D0851E" modified="2018-07-18" version="1">MASVDNAHLHPLSFPLTHLDRLSSLELALVQFHLDNDKPEHGKAVLIARTVWRERRRAAVEAGELLQGQRPPEVARRIRPARKLQPPPPTAALHAVHPPVPHKLVPLVENLRRVEDAGRTGTEPGPLSSNVGAGLKQRYPDAYTRDPKIKTFKDMMMAALDLGIVEAGRGEKAGRDWVRLTPPYRTTNHPSAPPALPSPAPRSPSPPPSLASLSLPTPLTPSLFHLANLAFDSHLEYLDSLSTSQLLLLQFRDDVEASEANSHLWTAIERVFWRRRAAAVANAERWSTQLPASHPLADVLNEYLPAPIASVLHVVQVEELPDDRAKTVLALSDLLPAHLLFVAATVSAPTFTSDTRTVHVAFRTLVLANSAQAYFAGLQLGRGGTGLPARILPAESVTHWRWRDVRPDERIGLWNHYELLPAAAKRPLPVDDAGDRSPDKKPRIERGIAIRNRDDAVAPQRVHPDDFVPVSCFSSMYPMSLFFSKMPAHLNTAHTRDDAFIYRFKAAGYLVKIDRMYLCFDSVSARHDFGEWVKHQAASYWKQNGLSIRALAPGMVVQYGWRFRDFSPEWRRRNGYIFDAAVSEPIVGELGFGPSFPIAPYELGLFNFEYKQQGREAPPPSFLPPRLATGNASVRAPSVSLASRLNTVDSTTRSPAPSETASHVNRAPTPAYVNGTLDAADEAEDVKPSAEVLRRAEELANAIRAQSASLPVAPSPVFADAQPLSPSPADAHRAVAPAVTAHAPSTAASAAGPAPSISSMSACTAEQPAPTNRRRRLTAMELTDFERELDDFTSSAADAVMGSASPPAATRSEAAPVNGAAMSSPPSAPTGSGSTETRAAQATSSAEQSQTLAIRSEGSLPGDYQPLTPVSLAAPFSAPASIAHSNTDPVPDATSRDIASTDDLAATPTVPAVPAKPLPPVTAKVGAAIPGLPVRPSFVDPPPFDYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAF1</accession>
    <name>A0A2S5BAF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAF1"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="428" mass="48597" checksum="F6440342221F0CAA" modified="2018-07-18" version="1">MTSALLRVPSHSPFPLSLVLPGPVSRGSRRTAYSWTRVLEMPSTRAQSRVMRAQLDNMPLELLRLVINFTSTSRFDKQIMRTNLSMVDKRIRAILAPDMREVAWFSPLQLESVPLDEDSVASLEVAWILVVSSPPCQPGTDEYGDEICASNAPTVWTDEYAIARVLNRFRRVKHLFLLGPPVCAWRFRFCFEVSFSNPVRDLSSIYIENCDLRFTLSVEPARLYCRQLVIKGCRLDNAEGISGLLEKGRVQLHSIVTLRLGPVDRAIGDERIPRTCKEILDLAKAVQLDCTPQHTPTNSKFPDPSVPSSIYFKTATPVLCTIDDLLPKLSRPKCFHWLPAPVTPLPPHAFHCARFIQLAELDCDLLSDMTTFLAALPNLRAVFLWRRLHPLVNSLVDREIDVIFTEPDDEAFILPEFMTYLREHDLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAK9</accession>
    <name>A0A2S5BAK9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="13">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_3356</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="13"/>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAK9"/>
    <dbReference type="STRING" id="741276.A0A2S5BAK9"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 13" id="KW-0288">FMN</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="14">
        <location>
            <begin position="384"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY73815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="519" mass="56453" checksum="AE1A17BC54023837" modified="2018-07-18" version="1">MSLARPMLNATRVGGRRIVARSTPLAAAVGASRSYAQVTDAAANPVRRHGGLQDKDRIFTNAYRQGDHGLKGAMARGDWHRTKDIVTKGDSWIIQQIKDSGLRGRGGAGFPSGLKWSFMNKPGWEKDPRPRYLVVNADEGEPGTCKDREILRGDPHKLIEGCLVAGRAMNASAAYIYIRGEFFMESDHVEQAIQEAYKAGLIGKNACGSGYDFDVYLHRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGLFGCPTTVANVETVAVAPTIIRRGASWFAGFGRKGNAGTKLFCISGHVNTPCVVEEEMSIPLQELVEKHCGGIRGGWDNLLGIVPGGSSVPILPKHQCEEALMDFDSLRDLQSGLGTGAVIVMNQQTDVVRAIARFAKFYKHESCGQCTPCREGTTWLEKMMDRFVVGRAHEREIEMLYELTKQIEGHTICALGDAAAWPVQGLLRHFRPEVEKRIHEYQQREGQVLFGGTLLKDTNPNIALPDNLGISLPGVAPGAPNSPNPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAR4</accession>
    <name>A0A2S5BAR4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAR4"/>
    <dbReference type="STRING" id="741276.A0A2S5BAR4"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="6">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="139" mass="15331" checksum="9AABD0940767C55E" modified="2018-07-18" version="1">MEGMAGRSRTGARSEGGGESVMLTDRLRSPTVLEQLTGQTPVTSKARYTVRHFGIRRNEKIACHVTIRGPKAEEILERGLKVKEYELRKRNFSATGNFGFGIAEHIDMGIKYDPVSSAWTSVRCHLLDLALDDGDAAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAU1</accession>
    <name>A0A2S5BAU1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAU1"/>
    <dbReference type="STRING" id="741276.A0A2S5BAU1"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="126"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="404" mass="44945" checksum="A983E425DFE0FB02" modified="2018-07-18" version="1">MAAPLVIVSSAGDAQPTADKTADKSHHNAKGGFVNPWPSFKSVNMGPSVPYQVWKDTKDPIPPPDKLPRLVPPTFVPPASLSAEETEAWYADLKTTWLGHACFLVEFPAEPTSEKEEGEERRRGFRVLFDPVWSHRCSPSQWVGPARVTKPPISLDEIPQVDAVVISHNHYDHLDVATLKHLYSAQPKGSLHFFVPLGNEKWMRDVIGVRKDEVSELDWWEERSLRRSDGGGQKNTASGPNLRVVCTPCQHFTGRTPFDRNDTLWASWAIHSSTGGKVWFGGDTGYRSVARDAPSEDGPTCPVFAEIGHRQGPFDLGMIPIGAYDPRWIMSPVHCSPEDSVELHRHVRSKRSIGMHWATWRLTSEEMTEPPKRLRAAGEKAGLAPGEFDVTDIGETVRIKVSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAU4</accession>
    <name>A0A2S5BAU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAU4"/>
    <dbReference type="OrthoDB" id="2570975at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="268" mass="29393" checksum="FC7B08CAA2EC5CA1" modified="2018-07-18" version="1">MPGALAAPRSLDHPFPPLLAPDGSLRIPTALPSRPAFKPSNRDQIALDGERVPLAFAQDVLRSVAPSLLESVEHASIHKDRDDDEDDHGDAAASRLVLASTVLPYPTLVLSVPFDDSDELLEMPAHRLVLATLESVLFEPLLDLQDPPVDGNDEQDTHIFFSLPVCSIRLPCRRNWSALHHFIYTHSSSDLLDTLLHTPIPAASSSEPSGSISSSVRHSREAIIDQLEGVRALHLNAATLQIPSAELWDTLRRAWHSLYSVLENAQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB15</accession>
    <name>A0A2S5BB15_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2786</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY73975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB15"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015629709" description="Protein BIG1" evidence="12">
        <location>
            <begin position="20"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="369" mass="38896" checksum="8641059AB74F254D" modified="2018-07-18" version="1">MHTTATLAVTLAAAASVHAFAGTYPVVAWSPNGHLPSLPELDAVSSTRPPAAQQHFDSSTSDLCQLDALYVVSVPGLHASDLASFPTTASSTFGFRASLAQAQRSGAARTAPYVSDRLAVPPVGKIARRFARCGAGKDLQFKRFDDLVGGGEGASYGASTEEERRVAVLAHLDSQIADIVASAPASAAFLLTDLPNKLSSASPPPLKLAKRQQLMPSDASEETIEEVLEEIAEEEHVNSNALDEMLAEIESAHEVESPDEDPSAPSMSTEDEADPYASLDRWDNRILDVSSSSKNASKNRTSIFAPAEHSGLLHRYALFSPSLIVAILVTVVVLIPAVLVGTQALLSIETVNGLETKMTGSVGLDPSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB18</accession>
    <name>A0A2S5BB18_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000031">
        <property type="protein sequence ID" value="POY73953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB18"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="335" mass="36030" checksum="EEEB731A5EDCB0BA" modified="2018-07-18" version="1">MPNPPSTSGVTTGAVAALTQPSRTLKRDLLTEHFRFAPESFAKGGMDLANRTMYTATAKVEQSLLQLVERGEEGFDEDEVQRSIYRLETLLEDAIDTQFDLFEIFVLRNTFTFADDLLPYISLPHHRTVPGETLITRISPAQRDQDHLDPSLKGSDAAILSEYEEELRLYESELQKERELAHAELFVKAKAAKAHEMAELVGYLKEPGKLSSTSNPTDRARTLASQLSQLEARLSELAATPVPHDTTATQPAVAPWATSRSAFVNWAAEQKAGGGQADPASSNPNPSAGAGAGAGAGGAGVGQLPQDVVLEKFQEEAAQVGGAEDAKALLDAMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB82</accession>
    <name>A0A2S5BB82_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB82"/>
    <dbReference type="STRING" id="741276.A0A2S5BB82"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="14"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="169" mass="18558" checksum="ECE11079C50F3CA5" modified="2018-07-18" version="1">MSAAPETHIKRGHIVTFSLLTVFSLIQWCIAAALVGEYNNKNTYPNNSYRDRIRFLLFVGLWTFVFSIVYIAGFLTAATNFLFSIASHAAWLFLTWVFWLAGSAAFAAALGGSLNCGNYELGHCSTLNSLEAFSWICFIIVTFMLVFTIWVGARSARSGNGFGGAVVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBB2</accession>
    <name>A0A2S5BBB2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBB2"/>
    <dbReference type="OrthoDB" id="2526024at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="47797" checksum="96EFDB1EE095A759" modified="2018-07-18" version="1">MADPRRAARMKASDLFDAESPNPGVDYLSKLPSELIGRIYKLAYAKAKPTEPLSRMLRPFYDEFIFRKVKATSDRRVKEFEQMLKDRPAIGLHVRDLTWEEEANPSDAARGSLAHAFSCMPSLHTLSFRTTHGQYLDLLLPTDDPTKSILPTSLVVLKLALSSDTRCDAYDPQKLVALGSLPHLTKLDLDFRHKYQSPQDAQSEPSELVLSRVHSLSVGLPKHLSSVNAFISGFPHLRRLTLTSHKSSPDFASALASVKSPAEVVELTLKASPKAGWRFPDELAALSSLAALNLAGKFDDLPLEAYQVFQHVPVRTLALGKKSTISGAALCGLVKSEKLTPGLETLRLDHLKAIAPDPDEYVTGDPQDVLAQFQFPEWTSAFTFQHLLTSLDLSRQRKIQAVGSAFEVIGIMAEQDLYMEEMGMWRTREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBD1</accession>
    <name>A0A2S5BBD1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBD1"/>
    <dbReference type="STRING" id="741276.A0A2S5BBD1"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="467" mass="50070" checksum="7E14786FCDA3CC7B" modified="2018-07-18" version="1">MATLRLRPASPNKEPWQPYMSPVSPTTSDAAGRFESSSTSLSDRCRKLAFRLGGSAVHDDEHFCEQPATPKEESSPKARRLSLPDGRSSPPRGFQNGSSYLAPSSPLSPRSHPPTSPDSTHILNEILEEGEGANEATPKAEAGPRGTYTPAPPSLGFSALGEGSSPVQWGAEVNQTSALGLTYEAGPPASGYSSSLAGTQSEFSEEEADSDAAAVIDERVAEIQNQLQDGATWQAVDIWLVDGDLLVGKSQQALTPSRTFSTTWVEPLLKIFSASVVQVGTAHRRRSSVFSHVKPSTPFQLVIRLRTPASMTFPYVVDALQPLQDASLLTRYCPNARASTPGLVTVVSSEADGAEMVPLEDLHAVQGERFVYRDVSLAALERAGEEQGKPLALDPQVTPVAAGELLPTTGWDGQSPLSSEQRARIERQVAQAHAAGLKVRYEALPQFPVHIRENVRTTLQGLGVDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBG3</accession>
    <name>A0A2S5BBG3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBG3"/>
    <dbReference type="STRING" id="741276.A0A2S5BBG3"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="246"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="327" mass="35838" checksum="EA6F0C7ECD960C0D" modified="2018-07-18" version="1">MVIFLIARNRFWSKFWWSLVGLIFCRVLQTVRPRVRMSATQPSVSLYVSNLNYSQVPKEEIRRSLYCLFATYGKVLDVVHVRKPKTRGTAFVVFRDLASSTAAMRGLDGESFYGKSLRIAYAKATSHATIAQTEGPEAVYAIKLGLRDADDAGKKSKLTVSAAQKKLADDRREAKRGRQNGNGAEEEEEEEDEDDEEGPQKKKSRQDGEDEDDAMEESDDEAEAPAPAPEPTFGPASAAQGTVPNPALFAEGLPTEVTSEMLSALFQQYSGLASLQLMPVPVGAPANSATALVHYETLAQATVAKEALDGFLVDRDAPMRVSWAQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBP8</accession>
    <name>A0A2S5BBP8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBP8"/>
    <dbReference type="STRING" id="741276.A0A2S5BBP8"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13182">
        <property type="entry name" value="EVH1-like_Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="611" mass="64220" checksum="554BACF25748CC51" modified="2018-07-18" version="1">MATSKDDVRRQLNLKNLQRHDPSIDRIVASTSYASIYDNKGQGWVKTGVEGPMFLFSRQVQTTAAPHYGFFVLNRNGLEYVQEFLTPESEVQVGGEFILYESGKNADRATGIWVFEEKERHELCRQMEQVRARAASSEGAKATAPGIPRGQPISIDMLFNAASPTPAAAQLPSSLPVARPSPMNPLDALFASAALSPRPTPASAGAASPRARNVQAPPYSDSSASQRLPSTLEQLFAAASPTPQAASLPPHAQHTSPPDRSPATGSESLTSRDGSGMALLDSIFASATQGASPWPTATQAPAQHPQTLRSGPNVQADVSALSNNSVQTTGAPSAVPPSQPSLPVSVPASSNPRDARDLLAMLGGLGTSPTKPAEAPRQAQYQHATASASASPKPQTTVHPQGLSMDPKPGAIGHESTVVSSSRRTKSSSSVSRSTEQTVAEKGQREAPSKIASQTMFAPPVLSHDIFATLPVPGQTKKEAAPRPSSPSPNGLPNAADGPSEPLSPSQREVQPASEQSKSSLDATTSTNSKRSASSASILLSKAEMITAIDDAVGSARVGLDSVDAASCSIDQAGPLSKEDFISQAMSVIQKPSFMTQLYGRYLERYEEQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBR9</accession>
    <name>A0A2S5BBR9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBR9"/>
    <dbReference type="OrthoDB" id="10479777at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="489" mass="55457" checksum="F9190D4AF0914EA9" modified="2018-07-18" version="1">MSGPLLSESSWTPTLETIPPELKRKIARHLDPRVHLEDKWSRAEELDADERRKSIMALSLVSHSWAAVMEDLRWQASPVTLVLRPTSLKKLYKLASELAPRFGHKVRKISLIGWQNDFRLRYTPQLITDAQRKELERIEEYVGLSPKTKTVKLIRITRARDALVAKILAACPAIDEIEIAGCLDAMCPRGVEGDWATLFEEDVFVGRTCKLLRQIGPKIRTARLTFDVVSNSVLSTDIEATVYLGWFTNVKDLEVRFAKLDSIEFSDLQCFAFAQLVHHLPDLERLALVGIDQVKTGLGYCSIMLPPGLQHLHLEDMNILAFDLDGCLKVVSPSLRSLALVDVECHLGAEEFATVHALPKLNRLCIASDVTIGLLRLFRRAPLAHVELLHRPWASWCGKSTSRTRPSAPRLPEYRFKQLRGFLDDHKKTMKSIRATAFMIVMAHFDRFNKLMADRGMRGEPLELWATEKYGPKKPAGDGWETCSDEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC66</accession>
    <name>A0A2S5BC66_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC66"/>
    <dbReference type="STRING" id="741276.A0A2S5BC66"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="201"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="301" mass="32787" checksum="50B212746DBEAA3E" modified="2018-07-18" version="1">MSKLVSLPGTGAKSAGYAPLETPIKEHTVSAGGIKDQPIELGDLANDAFFDEVARIRDAIRVTDEMISTLQTKQAYSIQSPSESLAVELSSLTSTLASQVTSQRSRISKLADQVGADEARRGHWENLKAALGRSVDKWQRVERDHREKVRDKIGRQMKIVNPAVTEDEIKAAVDTSSGFGQPQVFQQAMIGSRTDVARTALSEAQTRRSELLQIEETLTELAQLMQQVADLVLVQDSKFVHLAETAQQIEVDVEKGTQQLGTARVSAAAARHKRKLCAGVVLALIVVVVVVVVIEIRQSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCB1</accession>
    <name>A0A2S5BCB1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCB1"/>
    <dbReference type="STRING" id="741276.A0A2S5BCB1"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="427"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="576" mass="64675" checksum="1D308B8FDAEA91B1" modified="2018-07-18" version="1">MAGAIDFLAFRQANEKNNEKSLAESGFEQTATVAHQLAKTAKVVKQPAKPKAPKDKKPASAARPRKRKADTLAEDDESSAGDVVPRRSGRNQPTRAVNAPTEEEKERIAARNAEEERLQRETARREKHADRPVEANEGGTHFALGQAELDEEFRRLALYDESAHEKPAAKWEKGKRPSMGTKKLKEYAQDFELRSIVKIIPERIYSMVVHPDPTRDLVFAGDKSGNLALWDCTHAGERIPDAGATKLKNAVGDDGEDGGDDEEEQAETNYGKWWNWRAHRTNSVSWLKFRPGHMESIYSSAYDGTLRVTNFETGQSEEVIDGNALLEDSDDALIHSFDFDQTGNELWVSDNDGGIIWRDLRQPKNKTRRWNIDRYKVGCISVNQANPDLAATAHLKRYVALWDLKALRGMKQDSTIDEIIDKTQITHHYHAKACSSAYFDPTGTRLATTSYDDLIRIWDVDPRNILSKARLLKEGKDAKEFTLASQIKHNCQVGRYVTVFRAHWSTVPTLPPHLHVGSMDRSVDLYSPDRTAVANFYDAEHITAVPAVTACHPTQEYKYYGGSASGKVSFFTKPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCF4</accession>
    <name>A0A2S5BCF4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCF4"/>
    <dbReference type="STRING" id="741276.A0A2S5BCF4"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140535">
        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000005">
        <property type="entry name" value="Mitotic spindle-associated mmxd complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="4">
        <location>
            <begin position="114"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="236" mass="25628" checksum="7A864AB538C9BBA7" modified="2018-07-18" version="1">MVNATPDNANPTIHSSARPSSRRVRVADLDLSADDDLAWSLLGQQLEQEVQHLEAERSSATAAAGKEGTQAERTGDEIDADEIFGQSPPRAPGRTLPARVSRADQNTDDGPDLIRSISDPEHPLTLEQLAVVSSEQITVRNGKRPSVLVQFTPTIPHCSMATLIGLSLRVRLLRSLPERFKVDIKVKEGTHQSENAVNKQLNDKERVAAALENNHLLSVVQQCLSTADQRAGAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCH5</accession>
    <name>A0A2S5BCH5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Chitin synthase</fullName>
            <ecNumber evidence="2 9">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 9">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 9"/>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCH5"/>
    <dbReference type="STRING" id="741276.A0A2S5BCH5"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="481" mass="53610" checksum="110F1580DAA631D9" modified="2018-07-18" version="1">MSNILDKPLESVFGYITVLPGAFSAYRYIALQNNAQGEGPLKEYFKGETLHHSVDAELDAILMCLRGSLWTKNMYLAEDRILCWELVAKRGSAWVLHYQRSAYAVTDVPDRIPDLIAQRRRWLNGSFFAGIHSSYHFGYLYRSDHSFMRKLWLHVELFYQTYNMLFAWFSLANWYIIMYILTASMEDASFGLKGIHYFNIVVHYYYVALLLCCFILALGNRPQGSHGFYLVIIISFALIMVYMLVSPVAPEALWSAADATPGAGRNRIAAGVITYYSIVNAKDAIEASGGKFSVGDIFTNTTFRNIVISLLSTYALYLISSLIFFDPAHMFTSFFQYLLFSPAMTNVVNVYAFSNINDVTWGNRPEEKVSTDLGVAPAKGDGVDVAVPTSDTDINAAYDDACHVLASKAPPEKKSIDAETKMTDSYRAIRTNVLLVWVLSNAGLVAGILSTSAGSAVTSTQSNVYMAFLLYSVAGEIRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCM4</accession>
    <name>A0A2S5BCM4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCM4"/>
    <dbReference type="OrthoDB" id="2527649at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="79" mass="8512" checksum="BF8058DA0E319DAA" modified="2018-07-18" version="1">MADEGKTFSNDHEFASEQGKKGGATQPDEVYKPSEHDGLRKDGQPDKRMSSEHGFGGDREKASEMGKKGGHSTGGDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD06</accession>
    <name>A0A2S5BD06_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD06"/>
    <dbReference type="STRING" id="741276.A0A2S5BD06"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="61541" checksum="330A82B09DF38AEB" modified="2018-07-18" version="1">MTGPRPAATSSSAQDWVNAVLPPTPALQTCTYDPNSAQTRAVPNVSYRKHEAPLAPTLDSRFAHCPTPELTPPEDAMAVDPAAASYSRPAASSSTTFIKRDDLTAKAIARAASMSMPAQPTLPHKQFSTGSESSSTASGQPSEKDRLVSSLVGASILAIESIWGQTVSPPECSIAVKAGTDSVIPLHNFVKEVLRRSRTSCSTLQLALYYLHKSRRGIREAVSRAEASKGDIVRLEQELAECKRRAALAAAHVQTQPEDAYPSPPQSPNEHQRVDADARAHAVHASAVAAELGERFSALVAAQNSPVLCGRRMFLAALISASKYLQDRNYSNRAWAKISGLPVGEINTNERAFLKVVDFQLHLPLEEFQRWTDRLAALASPIASPVESARPSPPSSSQYGLARSASTYATVSPDQSQLAAGVRANGPLTASARHALSRGQSAAAVLGASVTATREKGFPIATARAAPAPLMEYREVASPTAMSTASFSSTCSSGSSDAGAGAADMANAPKRQLRSLPVRRAGASHRTSKPRGALVPNPTQAAIYVPTSWSSGGSTPRSTASSLGGPAGLREFGLEGLDIDGVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD48</accession>
    <name>A0A2S5BD48_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD48"/>
    <dbReference type="STRING" id="741276.A0A2S5BD48"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="252"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="829" mass="89668" checksum="D8C1CED4BA80832D" modified="2018-07-18" version="1">MLRAVARRPFSLLTSKPALVLCPRVLLTTTTARMPPAFATTESIWPLDASQKQAGTPSSSGEHGQGDSAARGKARHRVRRKPDSHVATSAPLGPGPSSTNAQTAALAPPVPPSNGAASRGAGKSKRGGGGGRGGGSSSSDSRRGGAGARAFSTSVRGGFGSAGASSTEDVGVRMNRAPFARPGGRPVPGGAQSVDWRRNTHSDAGAAHSDGPESAVEAGQGRVGKAKAKNAADSDKGTALLEQVAAAGDGLAAEIMRLYEVQRPSPAALAARQHLIDELTDWLNREHFRWGHPHNRGMYPLKIEPFGSVRFGLGTSTSDLDLCLLDPYRPNGFVDKYFSSQNAGLQTLPDIYNMRRIGRSLQQANLTDVRWIPEAAVPICKFKVMIDGHMIEADLNTNERLGVFNSRLINSYCNLHPLVRPLSVFIKFWAKQRGLNDPSGTPTTFSSYTLILLVIAYLQRIDLLPNLQDDDLIASTGTERNRFFSTPKARARRSRVDRIVRSVGWDVTFVEYESVPEGYSAPEANLVDLARGFFQYYGDEFDMERTAVSVWNGAPLERQRPFGAPKPSLAADVELEAAVEQNGDLSKAELQRQRDEDADLSAFAAEVTPPKAGEPDLDSLAADLDALRQDDASQQSRLGSSARVPDSRSSSPVEYEEYEEPERWADNLLVVQDPFILTRNCPGNVAPDWVEELRVQMRRARDLIDRNASIKEICAAVKDDPDYLSVADRKKGKSTRSRAKTRKPKPVRLMERAEQQAHDADAEASDGRKSTYIPEGPGAIPDPPELVETRQREQAAFQLALAPMVESKAAPATSGASAGTQEAPLDSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD92</accession>
    <name>A0A2S5BD92_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD92"/>
    <dbReference type="STRING" id="741276.A0A2S5BD92"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="262"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="3">
        <location>
            <begin position="576"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="83230" checksum="72EDC47B8665C3A4" modified="2018-07-18" version="1">MPSILPAYTVPDNSIRVSIDRGGTFTDVYFNYPDAQGDRAEHVIKLLSVDPSNYQDAPTEACRRVLEYVTGQRIPRRQKLDTTKFDYIRLSTTVATNALLERKGARHAFVTTKGFRDLLRINNQARPDIFALNVRRPEVLYESVLEIDERVTLVGYTYDTDYVKNAPQFDADGKLTSEHEGEIVQGVSGEAVQILRKPDESVVRADLQKIFDSGVRCLAICLVHSFTFPDHELLIADIAREIGYEQISVSSQLSPQIKAVPRATSASADAYLNPVLGTYLQGFFKGFEESLGQGTAKARVEFMTSEGTLVPVAKFSGLRSILSGPAGGVVGYSLTSWDEKKRIPVIGFDMGGTSTDVSRFDGRFEKTYETTTAGVSIQTPQLDINTVAAGGGSCLTFRNGLFHTGPESASAHPGPACYRKNGPLAITDANLVLGRLFPQYFPHIFGPTEDQPLSRDESVKAFEVLRKEINAYNLTEGNGKEMSLDEVAYGFIKVANEVMARPVRALTEARGFSTAKHILAAFGGAGGQHACELARTLGITQILIHRYSSILSAYGMALSNRAYEQQEPCAVEYNESNQATLRSRLDRLSSDVVAELNRQGFSGNRVEVECYLNMRYDGSDTSLMTLAPADGSFDYQAAFEDNYKSEFGFLIEGKAIIVDDVRVRGIGKSFDEMPASVLEEADRTTFSTSGVDAKAEKETASMYFEQSGRVHVPVYKLESLETGDKVHGPAAIVDGTQTLILDPGAEAKICSRHVYITLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDF8</accession>
    <name>A0A2S5BDF8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDF8"/>
    <dbReference type="STRING" id="741276.A0A2S5BDF8"/>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="797"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="805"/>
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            <begin position="953"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1051"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1061" mass="112625" checksum="18600B388910F60C" modified="2018-07-18" version="1">MDSPLSEPDSLSSAGAATEPLPGSDDSPLSPALSRRSRSQSLVGPDATANKANRTQRGGLDSDSSLTEQSSSEEEEDRDESDDAAADDEGEDEGAAGEDARDEGMATPRAAAAVAGNKRMRESLDAGARPLTDDEDDELSSASDDERDFDHVPSRTGPPAPKRPRQSGPTQPNHAGRSLSTSVVSSSTADGQPRSANMSADDSLSELDDDDDDNDNEATVERDRTLGAESADEVSDAEAGARILAKTLSGGGPTGPRRSHTPPASSRRGVSSPLSTVSSSSADEKDAEPVDEEEEEEDEEASQATQQSAATQARAEEEAVSTADAEPDRGQPAADQADDGDADDHGPSLSVSTSKGSRGARGRGRGRGRGRGGRGGKVSASGSKAVSKTPALDDTASPESAEPLTNGSTDNALPSNIPSPSGLVELETAPRALAEQLVELANADGDDENPLRLTEADANGDARDDKPANGVEPDENADVEMEDDVRPEPGPETEMEIEVEREVARRGGAKKGGKKGKGKGKGKERANDADGDYGDPVEAEEEEDASDAAFMRKRAEAIDDLTRIEIKFAQLRDMLYLERVADVEKERIGIENGTHPELIHLTQLIELRRNRKLELARKLFDGLSGAYSIQTDEREHANWHWWEDERSRTRLRFFDEANAKRSRLEREKRTLERPKDETLVALLAPRPHPAVPLAHRRRVGFDGEPLSEQEIAWAVRQPDLRADPTVRGLDEDSTYADLEQMGLREPSRPVRYSFAALYGQQPPHSAVFSDPGAYPYNTGDYDSTLQQQQAYASSFVTLPPLPGRSEQQGARSSSHPRVPSAHYAEAMNPHGGYVPAGVSRHHPSHPTGHGYEPERASWMQGQFQPKLGGGGGGYSAEAEQRRRTMSAGGAFNAQGSHESFMGLPHRSNGFVASPQDTIPGATTGRTTPVGNAPGGPKSRFTLDDHMSHRSPKAAATPGSSANSSASRPSSSMAIPAIPPFDRNRHEKHLLAQAQQTPSSDRRGAALLGGDSLPALAKPIGAPSLFSAGTGGHTSRNSQGDSPFGPAAHPLSSASTAAQRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDL2</accession>
    <name>A0A2S5BDL2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDL2"/>
    <dbReference type="STRING" id="741276.A0A2S5BDL2"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="599"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="599" mass="63704" checksum="1761047462939D08" modified="2018-07-18" version="1">MQATQDEQQVLAEIARLERAITSHKTTGDSMSYPPYRGGRGRGSGYRGRGGGRGRGRGGAPAPSYRNATWVAPGLASAAAPNGDSLIDAPPATSSRAASKSPEPSSSAAATLATPGLAATAARASPVPPPTREVTIDGVVFVAAPRGNKLFRKPQQDDTSVEVSVPEASTSAQTDSPTASGPLTPRRLSHLGTTYIRTKTGNLVSLAFARKRKELADARKAHEDEMDAKRDRLDKLVGVVKNVQGARNATSAGRGRGRGGYGKGATVRRAPRPKSDKLCRFFQRTGQCSRAHTCPYVHDSTKIAVCPLFLRSSCPRTAALCPLSHSPNAHRSPHCVHFPSCSRGVACPYAHVKVSADAVPCRDFVELGWCERGEDCDKRHVRECWRFAETGKCEKAGCREPHVLRRTHTASEEEDDAGEEDDTSAGEQGAMRRDLEEDVDEVIEDAVERTEADHVFGAGAGTEGKKRSRRDSTSDGPMGISGAAGRRLKRVKHKDESAAAAKRRVFAGQDDFVTLALPLSDEEGDAEETGDGVEGSDDDASSVDSGDLEDSESEDEVLQSLLPSQPDLASHSPTAASLVKQQSDTAGVPDEDALDYGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDU2</accession>
    <name>A0A2S5BDU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDU2"/>
    <dbReference type="STRING" id="741276.A0A2S5BDU2"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="143"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="447" mass="49449" checksum="DD7F7755F86388E2" modified="2018-07-18" version="1">MGRRFTVRGIDAFGKTMEDVKIKTGFGGALTLVSLSLIVMLTVWEYIDYRRVHMEPSVLVDRTRGEKLVVNLDITFPRVPCYLLSIDIMDISGEHQHDIHHDLFKSRIGANGKVIEEAVKGKELAGDAERIARQKATGYCGSCYGGTPPTEGPNPGCCNTCDDVREAYVRRGWSFVNPDAVEQCVSEGWKDKIKEQATEGCNLAGKVRVNKVIGNFHLSPGRSFVSNNRQAHELVPYLAEGGSHDFGHVVNHFSFASETEDEFVGMGGRRAKEVKKALGIVNPLDGIKAHTEESNYMFQYFLKVVSTKFQFLDGRELNTHQYSVTQYERDCTFSLSRAHSRSRHCAPPGMELSNNKVIEKQGGHQTMHGYAGMPGVFFNYEISPLQVISRETRESFAHFATSLCAIVGGVLTIAGLVDSLVYGHMRRIREGGAKTGLGFGAAQGKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE34</accession>
    <name>A0A2S5BE34_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE34"/>
    <dbReference type="OrthoDB" id="2529897at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="146" mass="14236" checksum="022B2EF4EC25A3D3" modified="2018-07-18" version="1">MGSGNTVIASVATDVNGDPISTRTLSILTSTAAAAATTTSTTTAAAENLGAPAQATYTQAGVIVTWYATTPVVVTPTAWSSGNVQAASAYAASVTTQSAYKAQAQSALAGGGASRYSAFPLASAGEWSIMLGVTVIGGLVGAVAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE37</accession>
    <name>A0A2S5BE37_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_2003</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE37"/>
    <dbReference type="STRING" id="741276.A0A2S5BE37"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="169"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="29"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY75027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="341" mass="35467" checksum="BE7B751B17C48D7B" modified="2018-07-18" version="1">MFAANRTASFAKRAFSSSSRQNTRVAVLGAAGGIGQPLSLLLKLNPLVSHLSLYDIRLAAGVAADVGHCNTPSKAVGYGPEDGGLEKALEGAEIILIPAGMPRKPGMTRDDLFNANASIVRDLAQAAAKVAPKARLGIIANPVNSTVPIVAEVYKKAGVYDPKRLFGVTTLDIVRASAFLSGIAGTQPKETDVPVVGGHSGPTIVPLLSQLPAGKKVVEEGGETLKQLVHRIQFGGDEVVKAKDGAGSATLSMAYAGLEWADALLRAMNGESGVKLCTYVESPLYADKGCEFFSSPVTLTSEGTVGEIHPVGDLHPSEQALLDECLPALAKNIEAGKKFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEC3</accession>
    <name>A0A2S5BEC3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEC3"/>
    <dbReference type="STRING" id="741276.A0A2S5BEC3"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="344" mass="37273" checksum="7629C2153257362A" modified="2018-07-18" version="1">MQARARPPQASILRQRTAASPNSLRLSPRRQFVAFLLLTALLGTTFSIVSVSPTTTAFRSRLPAHTLTKLTSKEAAFPVPSLPYFADKRNALNQVFVKRSWAWVTGLFFAFAGTVLLLPPTDTASTTSTSSTQRVPTVSNAYPTSTSRANPLAPHLIALTRRFLLASLYWFYLTQATWFGTRLGPSITHRILRYSGAVCVPSAIAHDPLAPRAAGGALHGGADGVKSMHLDGPGDIQSGTVCTGARGEYWRGGHDVSGHAFMMVHCSLFLFELILPLLPTLFPILFTGPKIKAHTGVKVVAYGAVAMIGLSWWMLLMTNLFFHSPTEKLSGFGFGLMGWVLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEF6</accession>
    <name>A0A2S5BEF6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEF6"/>
    <dbReference type="STRING" id="741276.A0A2S5BEF6"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="105" mass="11021" checksum="317D5BA7B3E09F60" modified="2018-07-18" version="1">MSLSIKSIKSLAPLLDRVLVQRAKVVEKTASGLYLPSAASQGPPPEGTVLAVGPGAPGKDGQVQPVSVKEGDRVVLPAFGGVPLKVGEDEYQLYRDSEILAILRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEH0</accession>
    <name>A0A2S5BEH0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEH0"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="488"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="789" mass="90266" checksum="288CB6AFB9237CA1" modified="2018-07-18" version="1">MEQRGEPQWRRPHLALPRHAAIAPDRTDAWPDVVVDQMGLLRDSEQGPKGSSPYHAAPSLFSSWSRSSSRQSTPLLPGQHAFAGRGLTIRTPRGDASRRHRGAADGLIDLLRVGGRSRRTVAYLAAAVVLFFYFVTGARIWRTDNSMRAFVEAGGFGLDYMGRAEDETAAARAQLGALAGKVDTGPERLPPVPVEGGLSKLCALFPWRKDCAAELKQARDPFQGLVFKEEHGHLFYPAVAAPEPPPTFEQQARRAAPVDVDAQPHPIHYLIREGKKAWKAKVARQSKTLREAVAEYEKRYWRRPPKGFDQWFEFAKKHDFVMIDEFDAMMDKVLPFLAVKPSTLAKRHQMIQFDQDFWIQDKTFTLELKGHGEVAELHGPMKSSNGRAQQMAHLLRRVGQFLPDMNITFTGHDVPWVTMSGETRAVHVEAAREGKVLPDEESGDYRDDWKWDGWARICPAESPIRRYASFDDRMAKKQVYKPPKQRSFIRDHPQAMDVCWHPENQLLHGFTAWPGPRPGILYPLFVSTSTSLHSDMLISPVDQWDSSIPKDPKWEDKEHNKVVWRGTTTGADLTIPHMRKWSQRPRLCKLPFTSGSVELPFSPDDEPRAPGSAGSFSARAQALARHWFDFKFLGEAKQCGNPEMCEDFEKDFLWDEWMDPAKQAEYKYVIDVDGNGWSGRFHRLMQSNSMVLKSTIFPEWYQDMIQPWVHYVPIQTDFSDLWTTMAFFAGDDFGHGAHDDLAKEIALAGKDWAEKHWRWEDMEVYMYRLLLEYARMVHRPDNGLQAWDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEQ2</accession>
    <name>A0A2S5BEQ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEQ2"/>
    <dbReference type="STRING" id="741276.A0A2S5BEQ2"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="18"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="931"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="655"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1213" mass="131175" checksum="A980E32B3CAD9B12" modified="2018-07-18" version="1">MHSPFSLSPLIRPDALGPDPITASLLYTDRILLGTDKGALVVFDLSNPAAATATAQDVASPTSSATFVSRHDHFMPKQIDQLAVIKELNALVCLSAGDLTLHSLPDLSLLSSFAPQTRGGGSAFALHTEIRHEPAASATPQPPPPTIRTTLALACKRRLILLSWVDGTTWNPLVELALPHQIRGMAFVDAADNSNDPTTSGGDGGGGATKIVAGFSTGEYGIVTLPTPDVKGAIKAPSLGDLFSLPIPLSEPKPAASARTGLTTGLSGLRNISGALGGALGRKLDKNGVAKVPRVPRRAARRGAQGVDEKDDEVLQRWLWEKEWGWTDAQREEGEVLVMRDNSVIPLSAEGRQRQAAKSSQPNPTITLSGSVDEALVSPPYILSLVAPSPPANTANGSSTPQLDRSPHFTLDVHTLSDLSPVQSLAVPPEAPSPPASIAASSLAALQGSTASRPPAYTARLLTLSSTTPKPPLLILTSKSASSPNAPASLAGGAEQTLWAVTMESWPRQIEALGRQEGKWEQAIELLRASYDSLPSPLPSGAQPTRCPVQPQPSLSRRLATLHSLHLFRTHRYDLAVDAWIALDLTPAKVIALYPEAVSGKLSLESDAHEGLFGGRTCDLVKQSAASVQAAGEGEDDSGSVDGRLTRGFVGTAGTSPSKSSPSTSGFQAPLSSSPARSRRGGPPATALAKSGSADDDDAASIRTVASRFSTTLSGKKSWLKERDPTAALEEIAEHAAQEEERQAKRDAENRARSVDELIRYLTDRRQKYSQALAALPSASRPKPSAPRPTASPGNLFSLPDKALTKLEPEQLVRVAQVVDTALFRTYLATKPVMIGPLCRIENWCEVEEVEELLLVAKKCRELLDLYNGKNMHQKAVELLKRAEAEGDGAEEKIRPMVRYLQKLGPDHLDVIFDASRWVFAQDKEEGLQIFTADLDEVEALPRSKVMTHLETIDRDVCTKYLEHVIGGLGEQGVEFHEKLVDLYLETLTSQRSTRDEAAYRKLLSFLETSHSYRADRVLGRLPSEDMHEARAVLLGRLGRHEGALQIYVYKLEDHTTAEQYCKRVYDSDTSGHSDIFHTLLRIYLRPRADHPVHFGPALSLLSTHAARIDAVEAFELLPPLVALQDMQTYLTKTLRQSVERAREAKMVRAVGKSAVDRATFEVVELEERRVKIGESRLCPVCHKRLGTSVIAIHNPRGEVTHYQCREQFSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BET0</accession>
    <name>A0A2S5BET0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BET0"/>
    <dbReference type="STRING" id="741276.A0A2S5BET0"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="215"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="826"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="724"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1198" mass="125334" checksum="B8636128FDD4D453" modified="2018-07-18" version="1">MSIQAIDRTSVHRLTSGQVVIDLQTAVKELVENALDAGATNISVKFREHGLEEIEVEDNGRGIDKEDWAGLALKHHTSKLASFDDLAQVETLGFRGEALSSLCGVATLSMTTSTSPTLPLGTALSFTHAGECVVGGKVSRSKGTTVKVERLFEQLPVRRKELTKNAKREMAKAIELVTAYALVKTGVRFEVRNILKGKSQVHLQTPASTSLRANFSNVFAPKSLASLMDLDMTLEVPTDKTVIKRLEDAGPSSTTVRITGLISKPSAPHGRPAGNRQFYYVNGRPFAPSKVAKAVNEVYKAFNSNQFPVVVADFQLAPDAYDVNVSPDKRTIFLHSEGNLIACLKEALLRFFEPEKGTFAMQAIGPARQTSGQKPPADGTESDDEDAEPPLKKKRTEDGSPVTTSPSAIGRLTRSRPSSRASSVVAEMNEPFGLDDVQGAVLPDPPASFSSETPVAATDLGQASHSPELSPGAAPPTAQAESLFRQQSATPAPARSPSPPEGPSASTSAQAVEKAPAPRMAQSRLNFASEGRPLGRGRAGDGTTARPTPSRAASGSAAQRMQGVLRQFLRGAPQRTGDIDELDELNDDGSEAHNDADEDDSAVSPAAAVTLLAVPDSPSRRRVPTQQDIFDTSAQSRDAAVVDQNEDEIVIDEQPEDVILVVEDSFRAASPLRTPRSPDGLNGADPPWTRAGQDEEGPDAVTASCVCVDGSQDSDLEIDEARSTPRTATIPRNMSTPTDSDQPQLFGAAQSEVAGTLVAADASLKLDLASLEALWTQMPAASAPSSSPVAVEADELVGAGIEERDEAAEATLSRVVSKADFDAMEVVGQFNLGFIIARRRVQHVDKGSDSGDGEIHDDLFIVDQHASDEKYNFERLQAETVIQSQRLLAPRVLNLPSSDEITAMEHIDVLRMNGFEVVVDENADVGERVKLAAQPVSRETVFDIGDLEELVELIASSGSSEVVRPTKARRMFASRACRKSVMIGKALNHKQMSTILQHMGGMDQPWACPHGRPTMRWLAQVVTDAQSVPSEIAALSSQFSGILNGGGLPTGAALQSDIQVLTSALANPTVSSYVFSNPSLSALARGALALAGAQSGSQSGAMASATSGASSMSGSMASGASSAARSGSSAAASGASSMASGASSKASSLASAASSGAAAASSAAASAKSSADKVGAFRGVLAPAAVVVGVLAGAAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEY4</accession>
    <name>A0A2S5BEY4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEY4"/>
    <dbReference type="STRING" id="741276.A0A2S5BEY4"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="36"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26488" checksum="4EB184803919C01E" modified="2018-07-18" version="1">MAAPPESTIAAKKPRLPRVFVIRHGETEWSLSGQHTGLTDIPLTEHGESIVRDLGTRIVGANKILDPAHIQHVFVSPRQRAVKTFDLLFEGVEEKPSWSKEDEIREWEYGVCEGKSSKTIRSELGQDWDIWTMGCPQGESPDEMRDRCDRMIKKIVDLAGAHHGKEDTEGHHGDIVIVSHGHFSRCFITRWCQLEISQGRIFVADTGALHKLGFQHRNFDERSLLGLNLYSVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF37</accession>
    <name>A0A2S5BF37_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl transferase 64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF37"/>
    <dbReference type="STRING" id="741276.A0A2S5BF37"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF2">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase 64" evidence="6">
        <location>
            <begin position="373"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="644" mass="73553" checksum="29CE881DE3D5EB01" modified="2018-07-18" version="1">MAPLNTRAKRIRLALIAAVCLAVLLSAFSPFHRRVSTAVHSSPDSQLFQGSGSTPDSHDGPGPYCAAHPEECAYAAMLCDDELLPALRVLIYSVHETDSPHPFVVLVLPEVSEAARKELAAIAEDVIAVPQLAYPYDGKVKFELGINKQCRYSKLHLWSQTQFRSLVYLDVDTAVQKNIDHLFSTTTNFAGVRDLGDVTNTGVLVLKPSTTTHQDMLDTYMTAPSYNRGDQGFLNWYFSNRTTAGVRALPPAYNVPPKLKGFAIGKKLIEDAFVYHFTAETKPWSFHSFYHIDWKLNYHPKMFSSWRNMQYAFHELHPELGDHYALPREPSAVRDQLVGYEWPNKHRQYELCHKYNPKYESSGKFPIQDQYSIAISYYNPERMQYLPKLIRHYLSSDRVHTVFITWHSPEAHISPELKALVSQGRVKIVKQTSDTLNNRFNPIPTLKTQAVFICDDDIFTPMSSVDFMFETWRHRPDQIAGFFPRIHGKKSDGSYFYEMAGVYHKYDIVLTKAMMINANFLHAYTCVLAPEIHRFIDMGKNCEDIAMNMMVSGMTGLPPVCFEEHQVLDFGTSRGISISSAFTHRRDQCTADLIQLFGRDTLVESREFVRQFDANKFRKVRWEELDDVLAMEEEARAGKAKAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFI6</accession>
    <name>A0A2S5BFI6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BFI6"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13704">
        <property type="entry name" value="Glyco_tranf_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1398" mass="156908" checksum="4B795C093E546E4E" modified="2018-07-18" version="1">MMHRLRDNLFTPRGADPTAASQGRIPLPMYGRLDDSQHRVSEHSRVDLIGHDQPSNSVWRQRLRHVAIVGLSLLLGILLARASNLHGTATHEGDFATETGVWADYGQFGDVRVGTKPLQVLEPCNRTLLLQWARYGSGLGSLVTASMQTILFAKAHNYELLFSREANAYGAFLDSFTPHSPRQCRITDDMYHHGYKVELHGVTSDAWKYAAPAQTPEEVDRLTLTEADIRVVNHWIRNTTFGNMSELDSLPATSGFAPVPGPDTVPALFRHRFLQYSALAAEYFQLNPTVRALRDKYKWDLGLEGTQERPIIGVHFRGGDKIARECRPSAHLSCGNITVHCMAAVEALSTFAPSFPSFALGTAKARLLLMSAEPDAPQLFRGDSICAQHFEVELFSHGGTHKSFDQLDFKAMTPEARIEDTHRFLAGIDILANWVDAAVVSANSNAGRMILARGGPSRVLDEQRIRSVDVPWHPFHMTPYAGLSDVTEPMLGTGLPGRIDVDRDHRDEYRQQRTPQRLLSWWQRTGRRHRQSIQARLSSNGSARARLLRLVGGLAAAVFLLNWVLTPSRPEPNSIRVEGSQAHWIPSSLNDWLGPNKEQGVDDIVTRIEDRLMKAPLPPYRMLVGTMQRNEGKSIVEWLLYHIYLGIDHFIVYDHNSDDDTLERLLPFVELGWVTVVPHNEESRWAQPIAFEHFRDGWKDQTKWLFFFDNDEFISRNVSASASGISDTPDFVNWFDERYSAHGGVAFGRLSFTTNGHYEPPHTGVLEAYTEARAVDRNFRAPKIASQARFMQKGGGDIHKQVYTGGMDLVDPLEQSGDDLLKADGGYPFYLNHYWSKSWEECVSRIKQKAFPGSWREQMGQRFCRFEMPETEEYATVQHFVVHDNDRIASSIWRAVQRFEERYAPLDRNAYSVSLLDSPTSSARRPLSLSGGISAGTTLVVDGDGLMPWNVEAMLSTSDRMYFLPARTLAKRGLAITLPPDLVAASAEIVIRRTYAANPSPTLDPVSPCSIMGHITGQPNRPQLLDLKNSVCRDTVPATAYSLSTTTWPHSRLRKDVLFQRFVKILPSSTSTASRPALPELAGGWRRENWPSQATPPRDDISTRVYTAEKCPHWFDGKYWAACGNSSTFARDGTYRWTATGADSYHGHSLPADEIRSCLQPASPANRKVRILVVGDSVASHTYMALGCLLEQASAASRTQLLSYHHLRFRSFQYEMFDFTSRSAPLTRDDWLKMLTWSTATVPPSAVDVADDDLPDVIMLNVGLWATTWAKAEDYRYGLELAAEHLRSIARQEGRGQVRIIWRETTAVFPQMDSDPLYQVNPRVEVFNDIAADVLLGVPEASRWRDGRVDGIEWLPAYEMTRSRGDAARDNAHMCPSVQGDLAEVAMRAICRNNGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFP7</accession>
    <name>A0A2S5BFP7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1211</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFP7"/>
    <dbReference type="STRING" id="741276.A0A2S5BFP7"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="102"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="442" mass="48645" checksum="729DA1ADAB46582D" modified="2018-07-18" version="1">MGAANWIRREWADAKDAGREIWQFVRTHDWRKTARSSLKRKYWVWWLVSIILIIAVVLLAIFRDKIVDQFEPHKETIVKFPASWVIPIVVLIILSFPPLGGHEIVLLVVGLIWGVWVGFAIACAGTFLGEVACYYVFRYFLTDHAAKIERKNIFYACVARMMRHGSLWIIIVVRFSAVPGHVVTAIQSTVGMSIWIYSIAIIVSLPKQLAVVWLGYEFGVNKQTADPAKVHQQKVISLSVFFGTAAATVLALYIVYMRARKLYPEIMREMAEAETGSKLSLTASGAPIGTVEDLEYGSGGGTTALGRRRSLAEAAWVGPWRPDLEVGDSSSDNMVGGGFTPAHLSDPWDSTSPAMKRDWATEDRIEDTSRPGPMGDDERARLRQSASDDAGSPPYQHLPLRSASEMSAAQRAAADSVAAAAASAPLQPGRQLYGAPVYPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG07</accession>
    <name>A0A2S5BG07_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG07"/>
    <dbReference type="STRING" id="741276.A0A2S5BG07"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="65"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="616"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="838"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="838"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1078" mass="115052" checksum="CA9AFC67922D856C" modified="2018-07-18" version="1">MPIQRTSDPAHAHQPATTARERDSPTSGEHRPSSQPLSQRAVRRTSTRRDVGQDDGEDHERIGPYLIKEEIGRGSFATVFRGVRYDTHAPVAIKSVVRSKLTAKLLENLESEISILKRIVHHNIVELRDCLKTDSHIYLIMDFCSAGDLSLYIRKRGDLPSLTASNQGLPAGDESVSSSAEKVLYPHPKEGGLNETIVRSFLGQLVDALRFMRSQNVIHRDIKPQNLLLQPATASELAAGHPPGIPVLKVADFGFARWLPSQSMAETLCGSPLYMAPEILRYEKYDAKADLWSVGAVLFETSVGKPPFRAQNHVDLLRKIERGEDRIKFPDEKRQEEGDTKVPTKVADDIKALIRKLLKRHPAERMSFEDFFREAETVSRSGTAAQLATSSLARARRGSSNGGGTVSNAIPAASAGDVTSSATHSRRPSPGYHPAFVPVPAVPIPRASPPVTAARTSPTPGAPSPAQSPQDQPPAHVSRFAPLDDPPPFARRTSMNPSGASPPLGTGPVGTRRASSYTSRYGTLGYEPGRDAPSIQRASSAGQSAVPAQPSQPTTTGPTSSNDAAPSAVDRFAANVRGTDSMMNSNDSVLGTDYVVVEKRTVEINALADELAQLSPRSEGVVARRPSRGFLSRPLSSIGTAAAGGQDPSPPSASSPVTPYPPGQAGGLDATGTPPFAIPSRPQPSPHHPYSMSSSPRPLSYLSSSPRSVSYQVDRFPGSPLALVGSPSAALAKAISNLSSLKIFGSPSDGILVRRSSARKPIPRSMTAPVAVDLEEERVLAALEDTAQKALVLFEFADAKLLQLLPPTPAASTSTTSLGTPSYFSHLAAREQAQAQSAAASNPFSAVPTSPSMRRNSSSSSGPDRPMIPASSAKADVLAAEATVLYLKSLAFLQRGIERARKHWSNRPSDQHAASADFNDAVQWFRQRFNECYDKADFAKTRCQDEIPETTAYAEKLVYDRALELSRAAAVNELRGENPSDCETAYETALWLLYALLDPTMHAGSPATAAEAEEDRATVTRFVHSIGGRLTALRKKLAPASGATTTAPTGANTAIAGSPASYQAGSPRVSVAPTSLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG47</accession>
    <name>A0A2S5BG47_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1147</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG47"/>
    <dbReference type="STRING" id="741276.A0A2S5BG47"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="15"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="535"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="583" mass="64099" checksum="A4D1F2A32D210D88" modified="2018-07-18" version="1">MPVTFHVNGAPIGGMAILIAVFSSMGGYDTGQIADFQEMDDFKLRFAQCGTPGDVATCAFSNVRTGLIVGMLSIGTLFGALFGASIADRLGRRKAIMIDCTVLCIGIVIQAASVSAWYQFMIGRLVAGLGVGALSAVVPLYQSEIAPKEIRGTLVCTYQLMITFGILVAYCICIGTRNLNQNGASWRIPNVLTILFALILGVGIIFAPESPRWLFFRGRHEEAELSLARVRGVKVEDQDYTVRQTYEEMKAAVEHEKSMDKFRWIDCFSPHDKILYRTVLLSVLQAGQQLTGANYFFYYGAVVFNGVGISDSFVAQIILGAVNFVRHLVDILTLTAGLLHAGLHLVRWTFHTAFCSILIPYHRCSLGLYIMERFGRRMPLILGGIWQGCWLIVYATAGTVKDPVTNKGIGKLEIVASCFFILGYASTWAPGIWTLVGETPRNSARAKTGVWNFALAFSTPFIVSAINYAYGYVFAGCIFAGSAIVFFFLYESAGLSLENVDRMYNDPKCKPWNSSKWVPEGHESRKDYVQALKAEEKATGDKPVHRDLAEDSRISHDGTVVGGTGSENPKWLKKHGRNPEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGE3</accession>
    <name>A0A2S5BGE3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGE3"/>
    <dbReference type="STRING" id="741276.A0A2S5BGE3"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="634" mass="71212" checksum="4D9225D0B8B2D3E7" modified="2018-07-18" version="1">MPPMQTPPWQEWRMEVPTKIPVDSVSFRNQHKLPRLPVPKLEDTLPRLVRSCQALASDPNEARHVAEKAEAFRRSETSRKLQQLLEQKRDQPGVRNWLAQDWDEQAYMAYRDSVVVHFKRLPQGPPSAHPAHEADPAYVAASIATTALEFRRQVTEGRLKPELVGRTPEDGELCMESYKWAFGACRVPATPSDYAVKTPEDAPEAQCFVVVKQNDFYRVPFADDRGRLYSTEALRQAIQDIIDGASQAVSPPVGILTGINRDRWAEAYGHLAETPANVQSIRTIQQAAFVICLDEAEPTEIVDFSRKLWTGECEAGNRWWDKPLQWVVYRNGESGFIGEHSCMDGTPTARLNDYLSNRLLAGEVATDRDTLSSPPTTELLRFQLDDKAREQIAAAEKEFADHIAPYDVHYTLYTRYGKEGIKKMKTSPDGWIQMLFQIAYYLTFKRLCGTYEAAQTRRYQLGRTETVRILTPEVVSFVHAIADDTASDADKLSLFKAAIAQHGKDMKLASAGLGIDRHLFGLKMLAASRLNEAERKQVMDGDGLFADPLVKESGTWRMSTSQIYIENAPSYGWGPVAEGGLGIPYMIHPHTLQLTVTCTRDVPGADFVRNFEKAADMLMDLHEAGERKAPAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGT8</accession>
    <name>A0A2S5BGT8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGT8"/>
    <dbReference type="STRING" id="741276.A0A2S5BGT8"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000475">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="41"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="610" mass="65901" checksum="E280ED928DB7CAEB" modified="2018-07-18" version="1">MASEDALPPPMQDAIPLDAVPLQPTAEPTRTARPTAHQQKYDRQLRLWAASGQSALEQAHVLVLNGNGTAASTLKNLVLPGIGQFTVLDDKVTDESDIGANFFLSASSLGHPRATQVVDFLAELNSDVKGHARVEPLPSLTDLGPYSLVLAVDVEQPGEVQRIAELAWEKRIPFIKVDSCGFFGSLRVQVNEVAIVETHPESIVDLRLAHPFPALVGYATSLDYASMDSEQHGHVPAVAILIKALEEWKASHDGQGPTGTAERKQFTDSIVKLKRQADEENFDEAVTLYRRAGTRHGIPAEIQALFDDPACQKVSSSSSNFWLLLHAIHAFTQHPSNPSHLLPLSGALPDMKATSSSYVTLQKLYKQKARDDLDLVKSLLNETLASAGLEQGSSTVKEEEVESFVKHAAWLKVIRGRSLRQEMGDECKLKGQIGEYGRIPASSEEEAPLANAQFNASYHNPGSVLASSSFQEPPDISLHIYTALRAADEFRSAHARFPGAASPEAPNTDVDLEKDADELTRMAEALIAGWKGEEDLASVGVDEEAFKSTLANACKEVTRATPHSTLPQTSALLGGLVAQEAIKLVTKQYVPLGATCIWDGIRSGTGIVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGX9</accession>
    <name>A0A2S5BGX9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly A polymerase head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGX9"/>
    <dbReference type="STRING" id="741276.A0A2S5BGX9"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="7">
        <location>
            <begin position="101"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="8">
        <location>
            <begin position="297"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="75775" checksum="76C9325112888880" modified="2018-07-18" version="1">MLEPWRPLLCHLRPRRLAVPTAPTAPIALRDSGSAPYPRTMSSTAGIPTIELTQDETRLVHLLTDCADWVDQRPDLVNALRLKDEHGEWIGRERTKDPVELRIAGGWVRDKLLGRQSDDIDVSTSPDPITGLKFAMLFEQYLESIGQRDLMGRLTKIEAKPEQSKHLETATARVCNLSVDWVQQRGQEVYTAGSRIPTVAFGTPLEDAERRDLTINALFYNLRTRSIEDQTGKGLADLGFVPLKPKRIRTPLEPVKTFHDDPLRVVRAVRFAARFGREYELDTEMERAIKRDEIKEALRNPQKISRERVGTELDKMLLGNDPRYAYELIERLELHPLIFLYDHPKSFHGPPGVVPSPTASPLPADRSSSPPPPPDTTVTVRAATVLARLLRPSSDPELPELHPLLQLSAVPFPESNDAHSAPPTYPPSVPETSSLPYLSHVYPSTIKRLFLSCGLLPLYDLVTIEKNKVIWVGEKVVRDGIKGPTVDIGFTKRARDAQEILRKLVKSVEGVAEAANGEDVKMLDEASERAEIGMRLRNPAVHDGMHQRWNVSLLWSLVLDLVEAGQDVASQRAVIETYNRFIAKVLAHQLDKRSFESTLLDGKAVNALLPFTKSSPAMPRILDLIMRLQLSHPETTKADVEGYLLDEARQEEIRRMVDDAKPVPKGKKRKDPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGZ3</accession>
    <name>A0A2S5BGZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGZ3"/>
    <dbReference type="OrthoDB" id="2530475at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="398" mass="44964" checksum="BCF795BF7C44E1BA" modified="2018-07-18" version="1">MTCQTYLCYCIAVTHGSLYYAAKAFDPLRDPLRFLRLVKRRIASGILRTGNDSSIARVPVEVWDIVKHKLFDLELAQAEEDFLEEWACAEYLLINMSGTTDVFVRYGVFVSTKSLLTTSLAYPKLVDPLRALALIRWRRRRGIFRSSSLAIEAVPEEVWELVHNALVKIEQDDAEYEFVMDLLCDDCHSESVDYMPTKTWPDLWDTECHWCAERRWAYEGLSQEQTKSQASLEEVRIPVHSEANKSTPTQASMLTQYGLEQPSDKCYPASRADDSVPFLTESPDSGILVSIPPAGSPSRRDAGVRSATATINFDEPGSDHRRDAVADVSLQLLDDADERFRRFILEMQLDVVDIVDVPSQDSSRLSPPKRVFVSVPWSEARPSSRFPGLKRGQNGGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHC1</accession>
    <name>A0A2S5BHC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BHC1"/>
    <dbReference type="OrthoDB" id="2504896at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1605"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1609"/>
            <end position="1625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1708" mass="176762" checksum="D170049B9DCCA126" modified="2018-07-18" version="1">MQDGRADAALDPRPLELNSSSPAQADSAGTTEQVQSKVQPQEVSGDAHEVTHGANEANDGRSDVVEQPGEARQTAQDAQQVTAQGATDDKEGAQGDHAGAQAGADSVREPAVAAGKGSSATSEHVDGTATAESQAGIQAGAIGAASDGTSTAAGATTAPPETVLAAPKPSNPAAIKSSLLLQVDGHPSPTGSPAGSVASGTPPLPVGTAPVVDENGAARASPAPSASSAAGSTTADKPVGTASAHPPVVKKFSSSLSVNKKFLEKAGEKAKPEIKPVATRLATPPAPAPASSGHPRLFAGKLSSTGTLSLSTTPAIPTPTGWKKPTSPAPPAATAGQAPSAARPGSGSTTGLPSRTGPAVWGSAARAAAAAQAGLGRMANDFPTAAEAAHAKEMRAKLLLEQVQARERAEQARAAAAAAKNAHLLEELDAFRGKHLDPNAHHWDEDDDDFLDTTIEFADGTQYKIEQQAQANSAAASVVDEELREPGPGELALREKPLAPGEVVEPPKREERFGDDFDRSWPRRPSAPGDGRNLFNERIGRLEPAASGKRPAAPEPSSILRPRERRPSDAPPHLEPKHRRPSVTSPKTSHAPLHPGPSVPARRPSVTEPKPNAWGRRPSVGVSERQLPPHMSAPGGRQLPPHMQASQPQPAPASIGGRSRGPLSPPLQRQPLPATAGTLRSPPAQAPSALAPASAPIKTEGTTPAATEAAPAPAPAEPVPNLEEMHAREMHAAAERAKKRREEEEQKRLEQIERAKRKAAELEEKMKAADEAKAEAQRQEREAKAKSDAAAKATVKSAPTGPPTAPSAADKVSSWRTGPRPSISTQKQPIASGSVPPSRILAREDGQPAISDPASAKPTAILARPNASGPSNSTATPPTQPAAWRRAEPPQPRTARQLPPHLARAETATAGADAQSVAKPTPPSAADVTARPTTPPPAVKGDGSSPLASPMHKRADSQGGTGKSGYKLPAVSQLDDLMSRIKGAMVPSGDGEATADGAAAGNATAPRVKLPAAPASNGATVKLPMRQVNAQTAPSTRGRGRGQGRADVAHPSRATGPTFEDREPQLPFHSSRTARSHSPPPAWKQYVVRLAAHPPRRRPQARQIRNFETLKYPQPLYPFSWTPALRDANPRRLSRDDMLLPKRYTANGVLIFPVRLAPRKVMRNFATGGPEERPTPTVSISRRALVRSQEAPQPVTPPEETTRDAPDSSQLGTKPIHAVFGAPALTTAFASDDSARPSPWRLPAPANGNAEAPESANSLSRASGTPTFGMTGDLNGEKIEATPRRETSAPGLDAAALRMNPKSPPFQPSDLANLPAAPASAAWPNKSLALSVLDPTAPSVWSTAPAETTVRIRTMSAVQPENSLQGLMDDDPSEVLPNSLAELKSDDGQSTEAQEAAVQEARLKDEARMRTMGPAAFSTFLHESAAAINSSASAAPRIPYYGDSALFPSGLEGHSPSPMPSYGSAQAYPAVYANSRPFGQPMYPGYPVGAPTGSPYATNGYPAVYSAHPYPAGPSPVPHGYAMRDASHTGMPLGITNPALMATYGYGQPAPRYGAVGANGPATTGRTTHNHSSPYARASMQPVPPTSFISPPYGSAYQPMAVPQQSYRPASPFGSGSHGSPPHSARLPGPSSTMASPVIVPQQLPPVPSFGTAVSPAAAYQQSASMISPHARSAGLPPYGGMHGAGYGSYGGRPNGAVPAGRGGPRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHC2</accession>
    <name>A0A2S5BHC2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHC2"/>
    <dbReference type="STRING" id="741276.A0A2S5BHC2"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="218"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41133" checksum="323312B1895FE940" modified="2018-07-18" version="1">MTAAPSSPRPRVIRVGVVGCGEVAQTTHLLTLQLLSDLYRVTALCDLSPTLLNHCGRKYSIERCYSDYRQLCQDDQVDLVLVLAADEYHAPITIAAADAGKHVLVEKPMTLTLEDARAVAQRNNVVVFVGYMRRYAAAFLRMKEEITKLRSIHYVTVRDIIGENSFFVNESGTFPMYPTDFPAGSTEDRRARAQAIADAALSPEQAASSRDVSTYRLLGSLGSHDLSAMRELLGMPTRCLAASRSKPDGPPFITAIFEYEGFTATYETGIDQVADFDAHIEVIGDGKRLKLRYDTPYVKGLPITLEIKERDEHGQYVERVIRPTYEDAYTLEWKSLHASITEGKPVKTTPEDAAQDLEIFDMIMKSLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHG6</accession>
    <name>A0A2S5BHG6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000007">
        <property type="protein sequence ID" value="POY76193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHG6"/>
    <dbReference type="STRING" id="741276.A0A2S5BHG6"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1137" mass="123938" checksum="2C042D396163A3E2" modified="2018-07-18" version="1">MEATRRGTVTPTSYDDDLPEIDLLALQHRDNHFTHFAPTYSRQLGDFPPEIIALIVHHLYYDYVPLPHPFPNPDPFISLEPPSNTYPAPHLAPSLDAQAKELLAGLCLVDKTWSAEATRALWRRVSFGMPRAFESVLRTIEEYSGGQRVARPLRSDNKRSASTDSEGSPSGLRRRASARGTGSSLGLTMTATETLPDAPIAAPHVPKTWEDSNTPQLGRHVEPVKDYFAAGGGGAQAESTEPPRTVPALQTLPTLDPADSPLLFTRAISFARFRTAGMKRTLRQGSNERFVTAQRLLTLLQGTRYPRKKLAKPVVPKKPGDSSSGDDDESSEDSSMDSSDEGDTTPYSRHAGRGRKQKKDAGQLCQVGFTEYMDSAITREVLEEMLFRGGYLAEYEEPEERTLIPSSSESDLSSSLPMQSPYLRPDASPLEPFHYRDLGSSHSRSPSSDRGHLPGERPRSSSITTSIAEEDETMVDTDEEVFGSGAQTPVGRRPAVWMQRRASGSAFMPSSTSSSRRHSSEDDFSSGEDERSGSETEAGDDTRMDDDDEEDHRGRDRGTRVRPFPHSHSSSSIQPLHSPPTFRSRGRFANLGVAPPGPGQQPSPTTMIRSSSLPAHSQPPLLRRQHTEVRRPSRRQVSMSRASERSSSVPASVAGRARWAPEPVPRRTVQVFEGSMAMQPLRGLDLCGCVSRVFVAALEDLIRTYKLGPPSLLPPPSATPMDSLAEVDDDGDDDSDADTDSLRFFGGLGADERILGRTFFPHLRRLGLASATLPSHLLAAFVLSFPYLTHLDLGSTLANPSLLKGLAVAGQRGTGGRPMRLRALSIARCRLLTAASILGLMCGDCPPLTTLAGLQDGSDCDESWGNGEVVAELTDLSLFGDRTYPSPLEAPELRLICSASPAFRSGRLRTLDLSSSPVTDQVLQELIPAQPHLLQLGLAYCRSLTMQAVASFLCEKAPAVEVLDLAYSCPSTVGQGISSRRRVTLGQPTISIMELHAILLSQCASLESSSSNPEEAQLFLAFRATNLRVVELDEKSLELVQGGAGDWKPIWGKGRRGWYVDTATTSQLTPAHSPLARPRQLVHLPRDDPQRLGLLHLAKQPGAGVFEIGWLARKFEVMKGEGMMGSREGLFAFHAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHT6</accession>
    <name>A0A2S5BHT6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHT6"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF1">
        <property type="entry name" value="UPF0590 PROTEIN C594.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="389"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="511" mass="56293" checksum="817A81D23B2743CF" modified="2018-07-18" version="1">MTPRLQVTIGSDRFHEEIAWVNHTSRPTEIDTPNFTGRVLVLVKDFAGVTPDGSPPKRDAQYFEGRTRRFGILIEGKWKRQAGVQPYSGEEVQFGSDFEYLPESFPSGPFNLGMRIAQRIDPATYYEFHPPHGRPYIMSPYVACMNTFCAYPAPDAFPRAVVLSRDEPEKDATKTFVPTEQKDGKKWVEQQHWSFLGLRGDPRVDTFLAEHTHLLPAESAVTATATSQSSLAPPERPGLTQRQSSLILGTSDRNDPKLQRSGSPEDDMMAIATAEGNGVATNGADARATALRHSNASSVAGSGTATPTSSGATDAPKKKKSGSRFSLSSLVHALDTSSSSSNSSTANNDHLVAPHLLANANEPGGRGRAQSVSAQYQPRPSVRKELGPWRFADEEIDATEDTSFVFLDPDHPRTVSQRRKHFCSENGKHRREFTYDPDCIYTASFFTPFCDLNTLDLKMGPISLNVAPYFTKMPIRYTLRSTRMTPRPDGSAGPLEEEVFATIGFRLVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI36</accession>
    <name>A0A2S5BI36_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI36"/>
    <dbReference type="STRING" id="741276.A0A2S5BI36"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="314"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="692" mass="76850" checksum="1588EDD1EC8B64CF" modified="2018-07-18" version="1">MDYGQPSGSHHRPRSVATTRTGMSRRSSIASRQSQLIKKNTGPFELRPSDILIERFSAWKRLVKNLITYFEGIADIESNTAKELSKLGGVIQVPFREGNQFLGEGGVQDIFFGVRERTRLIADHHANLAKTVEGSIVQHLQKLHTEVKAHIKNIQQDTGKLAASVAKEREISTKMITDLARSITMLKNTPMGVHAKEDPWYTNSLVARQLQKQVHEENALQKSIIIMQQNSEHFEEGVVRAIQMAWQTFDEWNARASVSVQETWATMGQLMRSVAPTTEWIAFASRSEYLLDPETPLRNPMTINYPGKEDPSVIPVHQGILERKKRYTKTYKESFYILTPAGYLHEYPTSDLSKHPLPELSLFLPECTLGAPTNPHARSHKFHIEGKKSLGGEVGQKSGLFKLDASYTFRARSHDEMLEWWNDCKQLSKVYLTASEPFDRSGPVPAAVRAVGYVEEDEEDFDDEEEEEDEEEGSSVEETDSDGYEEATAHHQNGRRIANGGHHHHHHQQQQQHVEEERQHHQHRREEREAAPPAQPSQSYVDRRQQRASSTTNAASTGAPHLGATVDHAPAYSAPAQGSGFQVGAGGYAVEKKPDGNNGAGPSSSSAAHSRPVPNRASPDESRQSQRPPVQAQHSYREHTDDSSEEDDDGGDTEAETADEHVGEETPTAVGHFVEQLGGGGGGAEHAAQTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI67</accession>
    <name>A0A2S5BI67_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI67"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="252" mass="27575" checksum="DE01D0E8861F3883" modified="2018-07-18" version="1">MPNRLNPLPLSSTLHFPPVRGSDGAIEVPPHLPDHPPFPVSTRRHVLLDGESVPIPFVRHVLTSIAQPMLESVHGPPVFTVDSDADDADPASTRLVVVSNPLPFPNCVLVVSFDDRPDDEFETPAHGLIWATSGSSLFEPLFDLDEPAGSPSDEHEPHSSETLLTLPAFYLHVPFQHAWTQIHDFMYTRSPADLLDTLSIHIPTPTQHARTIPSGAATPSSDQGDLLDQLEGLRQIYLTAVCLQLPDDVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIG4</accession>
    <name>A0A2S5BIG4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIG4"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="75"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="434" mass="46740" checksum="005037CF1B0FADE7" modified="2018-07-18" version="1">MPTCQPVPSDDGTGTHSVNTTTDTRRMIAHSKLQTHAIGESLALGLTDESSRHLATTTTTAATLESHSADTTLSFRLLHSLPTELLESTLHYLGVCDLLRLRQVDRALHTLLQDSRHYHNVSLSHLPLSSHADLVQELPSLLPGTRHLSLRSFPAPTLAKLLPVCSPERLTSLDLSFSSVGDDDLMALSIGGAGGGNGGSPGNGPAHLRSLRLKGCRRISDFLTRLVLETADSTTSTKPRPPTHALSNLRVLDLSWSAVSDLPLPLSSHLPLLLTLNLSTTPYLDRTVLKGALETLPCALTDLDLSHLNLTAGDLAQLAFSRPVDCPLPSPARALASVGGTITENELTPVRLVLAGNDHFTLSALSTLQAHWSPSPSISLLGRRIQVEHGGLLLESDEEDDVRRFVEMVAGVVMREGRRDRRVPGSRLDDNSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ58</accession>
    <name>A0A2S5BJ58_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Timeless N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BJ58"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="6">
        <location>
            <begin position="109"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1061"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1102"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1162"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1072"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1196"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1224"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1235"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1249"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1320" mass="146379" checksum="7AB51F47A8FBCAB1" modified="2018-07-18" version="1">MPRYKGYASDDTQSEQEEEDELDRLSNRSSLRDDDDDKRRGHGADDDGDSGIMSDTGAPMNAQQSSPERLCAPTDRKRAALHPPISSICAALGGFEEFLDENGQLYTAYSLGDQVVGCLKDLKRFWRMDEKDDDRTVARIFHEVGVLSSDLIPILKTTLGTGAKGDRIALACVELIGAMTWPIDVAQELRDAKLLGGLKAGMDYATLVSAQRTYKAAILKEGVLRHMMVILANSLQKSRRDRTPKDENVISLVLHVFRNLAYLTDRHTTSTSATAIEDSQLQSDLIVSFSREGILDLLLAMSAQADATDYAPWNMVVLDILHLLYRGIKADELMVPEKEVEQTRLRDLLDREAKLQDRDFGLKGSRHSRFGTTIAVQSNGQKYILHKQSTLAEGPEKTLDKVKRTRAKRVRQEDDLAPPTQLRPEAVRVMYDTSKKFVESSFNPFFSSILRDIRMERLKVRESDTVRFLYLLAFFLEFFLLLYADDEKRGISHLDEERGHDFGLVAEMTEPHAIGFVALRMKNALEEKRPTQPPLWTDLHAGVACFTQILLVIEALQASGIPEHVDVAEILQNKLYYEAETLDMVVGLITKYNAQSYAYLDSIINLAYTLLRMLEKYSKSKAYMYVRKKRAGRAANARKKKHLFTELIPVTAAEKETGDENAGDGLGMGGEEDEEELEVERGTVSFGEHAFQFEKFEQRFADESVLPTYLVYLEAYKTYRSPEQMKRIVALLHRQAVKAKSEALFYKVRSTATELMSGFVELTLLAHQPTVLEIFKRLLDDKDIAEAREGPKVDLRKLIEYILRRFFKAVQDHPSLLLEVGREFSLWCDRKLSLNVIPLQCFFPKTRSQLGKMRLGEADPFADSDDDTLIYKAKKVGEVEVEPGFSHTQQIGIAMACLIEAGDQRLVDLVKDQLALASAARTEIVLTVDGPSADADVAGAGTETTDEELRKQAAALKGPSEAALALFAPHDVDLGSDAEVKEAGTVNPHFKLLMRLVGWESSEGIAAPPKYEGEAKLTRTACPALDSGQLVWVVPAPLPPSKLDSDIKIINDFLLDPVDPQSGKSASELLRKQRKKPVRRKRRIASDVESGVELEFEKDGEPVVKQKAKKKRQKKREEEEAAYKSAQFIHDSDDEEDADRDAAFFASEAALREKLNANAISVHLDSGSKKRKEPRASGAAGTPSVAASSSPVAGKSRGKKPKAGRAGKGKKAKKTKFDAAILSDLDDEEDNALMDDLREKADRLRGATDADPAADASSPRAMSTPDAASDQSSPAPPDRSAATAVRSMSSDSDDGDTTAPAAASQPAKRRRVVADSDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ65</accession>
    <name>A0A2S5BJ65_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial processing peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ65"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ65"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="4">
        <location>
            <begin position="50"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="5">
        <location>
            <begin position="203"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="59070" checksum="ED3A765EB3A0C7BC" modified="2018-07-18" version="1">MLAATARRLVPSPRAWRAISSSRRTLSTATPLPSSQDSLLKVTTLANGVRVASDPTPGHFVAAGVYVDAGSRYESAQTRGAAHMTDRLAFKSTANRTADQMTTEIEQLGGQFISSSSRETILYQATTYSHSLPSVLSILSDTVLHPRIEQEELDIQREAALWEVGEIKTKPEMILPELLHETAFKGNTLGNPLLCPEDRLETMTPESLREFQRMWYRPDRLVVAAAGIEHDQLVELADRYFGAVKPVTSASLPVGASAATSRSNPASSVSSSSSSAPFSTFTSKLASVVSGSPTSLPAKEESYDYLANAPAQYTGGTLLLDNPDLEFTHIYVGYEGLSIHDPDIYALATLQVLLGGGGSFSAGGPGKGMYSRLYTSVLNQYYAVDFCSAFHHCYLDSGLFGLSISVEPSFLYRTPELIAQQLDAVTRPMKNGITEQELRRARNQLKSSLAMALESRMVQVEDLGRQVQVHGRKVSMPEMAELIDRVTLTDLFRVANRVLRPSTSPILSDRKRNGLPTVVAQGKLRGLPDVTDALRRRGLAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ74</accession>
    <name>A0A2S5BJ74_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ74"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ74"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="549" mass="61213" checksum="842D4F7F011C555A" modified="2018-07-18" version="1">MFKEDLATSAKLAAFTLLSPPAAGARAGPSSSSDEPGSPSQRAVFIASPSAWPTTDSARSDSPGWGSAYGFGRRNRAATRKGAGHLTQGTYKWAAIATLLLLSIWVILPGGSHSKDRVHDITDGDAPRFNKSLVLQHAEPQETFFSQLLPGVRYITSMSYGGHANQFVGISNLLYVAKITNRVAIIPTLMPLHFSGAPQDLTVFYDLDRFIRESGIPAVLQSDLKPFSSDPAQLTTEKISCWSILERVAGNRNFNDGSMMVHGMDVRNWPLPFESGPMMWAEKVQEFDYELGERLAWIKRVNKELLPQETALPAQKPGDRPLNRHETLKDGFDPGRNDPPTDQMFCLDNTFFLATRVFPPAIPPSAPLEPLRSYEGQGWLRAGQYLHFSAHLEALAERYLVSLFGLWTARSIPPFISVHIRRGDFEQARGLTAIDAFKDAVQRVRDRLDRRMDDPDGWAGAGHELQRYFDGVRGKDYAVVVTTDDKMDSDFVRQIRSELGWKVLDHDKMQTIKKYGEWYPTMIDAAVLARGRGFVGWNGGVEEWTPSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJC6</accession>
    <name>A0A2S5BJC6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJC6"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48273" checksum="B7219E2ECC2A9D12" modified="2018-07-18" version="1">MALTRQAVAQCTQSLVRSARPSVARPCARRTAPPCALDAVRTFTSTRRARSALPWFVDAEDAPPATPTSDAGLIESGPRLATAPVPTRPPAHLSPALHPLHDFLSTSPFLDKDSLVYIHAREADPEASWCDWIVCASLRHGRERGLRGAIEGVKRHLAAHPVELPTDPDSATYGSAPLPFAPPSSRPNIHGLPTAPTKHARSRSLRNSRSSSNSPSASDAGTGWALLDAGTLVVHVFTPQARETYGRNIEMMWEKIGESEHRARGGQHGEWKSSARREEDRRRAQELEQNMREVQREIGQRFRPKVESQAAPLGEEDEGETQEESGGGWSAIFSSPSSVKHPRQSWTQDELATLERLPKLGRSFAQIAKALGRSMSSVERQCYHHHTGHRIDWTDDLDKQRLTAAGKGAMLKQLGSLLGVSPMSAQRRLKKLRSDDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJD4</accession>
    <name>A0A2S5BJD4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_0128</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJD4"/>
    <dbReference type="STRING" id="741276.A0A2S5BJD4"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="13">
        <location>
            <begin position="72"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY76876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="204" mass="22692" checksum="03152E4802AB87E0" modified="2018-07-18" version="1">MPATVRVKQITLDSLIKPYDRPVSSLEKKQEPANATPGFENIALGRTPPPFPTTPTARKAFLRPKSQRKVTPFQWQLYDALLTIPSGRVATYRQLAEHLTGSANGARAIGSALRENPFAPYVPCHRVIATNLYIGGFGGEWLPTRRRRRRETSKDIVDGTRTNEKLELLKQEGVTFDSKGFLKDKTKLWTPPCRPPKAAGATSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZT9</accession>
    <name>A0A2S5AZT9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000151">
        <property type="protein sequence ID" value="POY70053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZT9"/>
    <dbReference type="STRING" id="741276.A0A2S5AZT9"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="197" mass="22082" checksum="4DACE2BE9376EC34" modified="2018-07-18" version="1">MADLEAGGSAYSHPSRRRTGHTHHGQPRTEEDLSSTAVVWDNELREWRSQEEEVEGRTLRSRTPEPSHDGIRQSPTRDDERLSEVTVAEGGVVGEKQGRRESVAMDPLDSVPSSALAAKEFGDGQPIWLEWEKGDPENPFNWSPRKKWQTCLIACVFTLSYEAQKELTTLARAAGGVLWDGILERHAFDDARVEVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZY0</accession>
    <name>A0A2S5AZY0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000148">
        <property type="protein sequence ID" value="POY70086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZY0"/>
    <dbReference type="OrthoDB" id="2527531at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="288" mass="30962" checksum="C41AB9BC2808AAD2" modified="2018-07-18" version="1">MGLAHFAAACPAERPTLQAAQMWCIAQEGICCGICGNTLAALGSRAALGVFFSTAVTVVDGAESPFNFMTACVQAVAYLVVILVKGFIHAYYALVAALGFLCPLAASAVTATHYNYGGAHVETGKRLKRYGMDPTRSQSRARTSLIAERSLGPFSPTAREQLHATRARQRRHRPPNDQEKRPLVSMRENSPTFASTLALALAVRPGCDLLKAIWKRACAPGQLDHRTTRRASGAAPALFASEKVDCSAAGVRRNATRRSTLLGGDVFTQQYPVDPASERELARMNDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZY4</accession>
    <name>A0A2S5AZY4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000146">
        <property type="protein sequence ID" value="POY70093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZY4"/>
    <dbReference type="STRING" id="741276.A0A2S5AZY4"/>
    <dbReference type="OrthoDB" id="539541at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="5">
        <location>
            <begin position="217"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="328" mass="34980" checksum="094956B4AF7140ED" modified="2018-07-18" version="1">MKASASLSSAARTVLSGATPAARRPAAAATAASRRTASTSAPAKQEQQQPQQATEDAGRLPANLTYGQTARSRLGEHYESTLSHDLMYLLYSHATHAAGHRPNPLERKPIWSPENPYSQGRSAPPRPKGNRYIVPNPNYTSPESVPRLESIVVESMYKHAVGAKSNLLPLIMAFQAITGEPPQTKTPGPYGPGSGQGIQVTQSTKASASFKIRAGMPSGVKVELKGEPMYAFLETVVDFVLPRLKTFSGIPLPPASHPRQSPSSTSGVVSFGLPPEAMGLFPQIEVNLDQYPRSFGINIFCVTNAKGRGAQDQARALLSGAGLPFVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B089</accession>
    <name>A0A2S5B089_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B089"/>
    <dbReference type="STRING" id="741276.A0A2S5B089"/>
    <dbReference type="OrthoDB" id="2528685at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="652" mass="70096" checksum="7526417D454140F2" modified="2018-07-18" version="1">MGFFSRFRKVDSTTRVAADEQLKREAKQGAKNRRQSRVDLNHWESKYGRDAAVDSAATGVSSSSDERTVVHFEPTAMEKSRSRGSISTFQSYKPESAANAPGRSSIDFLPRIELSYGDPTAYSSPTIASIVPSPSPSPRLSRESTSFDGGRRPPLAVIQSPDAGARSAPPSKRESYLSERQIQIAAPQPRRQSRAISMHSLALPSAGRGLATSPRLQDLMDDPAVVGDGTDDDEVPLAAIRSRSSPLLPQRNSMYTLSPPSPGLGGPAASFSTPSLALPTSRSRASLSIPSVLLPPSPTLEALSTPRSLPRQDTQRSLAAIGKTGTLIDLTAPSSFDPYYERNRRAQAGATAERIAVGERRKTSPAGGFKPASGPTSGVAHIMEFGELEARHKKRISTLQGTANEKVEAEKALALYQEKQRKEAESQRRREARRSVASNLDQLASGSKGARSAESTKQRSRMSVSNLSLLLKRGAPEVKAAAMPNPPVAQEDEDDDDVPLQRLARSPSGTVLPDQIRPRPRRSSTQGLTASQSRKSISGAAGGPPRPSLGTRRHSLGTLLEVSHDQADIQADLLDLHSRGSPSPEVEKVAEWRRRSSVQLSELADSPARSPTPQRAQRRQSGVAFGEAVVLQTAAAAAPTQPKKKAHDWLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0F3</accession>
    <name>A0A2S5B0F3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BMF94_6844</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0F3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0F3"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="18">
        <location>
            <begin position="552"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="910"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="POY70258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="972" mass="105528" checksum="D18E2844163FC6C9" modified="2018-07-18" version="1">MTRLSSPRRRDSTRPVSPSTTRTAARLGSLAACAIWIAAISSLTAVQAEKKHPAKRSYDSHVYYVLELDESHPHALEWSPEDVAEVLGAEHVEQVGELKGHYLIRAEASQVASGEEAWTAAPVADQTRVRPRSFAGLEEGKRDRILERYDLLRRRSLGGHAQTSKRSSAALHPRLILSLERQEPRMRVKRDLPVLPPTARSFRNLPRRSSATELISAAASKFSIFDPLWPKQWHLVNGVQTENSINVTGVWEQGVVGKGVNVAIVDDGLDMHSDDLAANFHADGSWDYNDHTALPEPRLSDDQHGTRCAGEIAAVKNDVCGVGVAHGAGVAGIRILSASISDADEASSLNYGYQTNDIYSCSWGPPDDGKSMEAPGRLIVKAMINGVQNGRQGKGSIFVFASGNGGAVDDQCNFDGYTNSLMSITVGAIDRKGLHPFYSEACSANMVVTYSSGSGDNIHTTDVGKNTCTDRHGGTSAAAPIAAGIFALVLEVRPDLTWRDMQHLCVQTAVQINPDDPDWQMTASGRPYNHKYGFGKLDAWAIVEAAKSWDLVKPQAWWQSPLVFADAVESQQGKPVTKDGAVAELEVTTQHLREANLERLEHVTITVHIEHERRGNIEVELVSPRGMKSILARPRRFDDEASGMPGWVFMSVKHWDEDPVGKWTLRVRDRQDNGKKGHFQGFSLALWGSARDAAIAKPYRLPVEGGEEEENEPLATATEEPVTSTTAPAVAVDTTKAQPSKTFIKPTAHLPDDHAEATGEAHSSFGEDYHIPLPTATDAANAGEQFEDIQGSYHLPTATSVSDSLYDATPGYLAGVSALIGSTTWLFVAAGVIIVFVAGATAFFLLRRRSAQRGGAGRGGYAFAPATDFEDYDEDDDELVPMSAMERGRVRLAGDAGGGRTRELFNAFALDSDDEGSSDGEGATRHAAQERRSARSSAEEIEGIEKGLLDDDIDDQLPAADRERKAREEFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0Q6</accession>
    <name>A0A2S5B0Q6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0Q6"/>
    <dbReference type="STRING" id="741276.A0A2S5B0Q6"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="529"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="609"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="706"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="787"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="872"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="926"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="961"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="979"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1060"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1072" mass="112733" checksum="6C1A35631F070195" modified="2018-07-18" version="1">MDDSRPVATQQADEVAARSILVPSAGSGSASVGNPGQLESQPPTRLSDAPRTRKSPPHLTLNGLVGRASGGDLAPTRVPLNARQPSLVVEPASPAERQYASTSPYPPPIPSTSTSLPTPFIAPSSSSYAGSFIPPPTAQAQQGSGLAARRAAKLGKKRLSLLVPANPHSSVPIPGPASASVDAAGQTLLSPLTPSFLLPTSLKTNSKGTANPNGAVYDAEIRSLPPSPLSLTTFIGPEGAEAPDRTIGRLMLKQQADEMREQMRGQRGMKRRTSIPRLNLVKTGVAQAQPANLDSIASATSLTSPAMSLSGSASSHLSRALDSGTSGVATASAVQFIRSSENSPNDDAGTGAGPVEEFPYALGPREILPGIFLGSEQNAKDANVLRDWRIRFVLNVAKEVDCPWTDEADALLADGALDDSDVRSASTPASSTSAPSMEPKVRTPSTGARPVPPAGPRRAQSHAPESTTILSTSPERVLSPSGNALTASPIPVRPSFIRPTASTPNLHASFDPLASPPPPPLPPLPDLRDLSAVYPSLAESAQKPESPLPTPSTARHSFGASRRATHPTMSTCRSPDAMRIPPNPTSGRPELEYLWLKWGHDESDLVEAQKFQAAFDFLDEARERNERVLVHCQCGVSRSATVVIAYCMREAAKALEEGREATDLAGCTGMHDTYSFVKEKSEWVGPNLSLVFQLVAYERTLRGDSINGDDDLSEPPSAAFRSGPPATFSSLPPATPLDVERPVPFPPPASARPMSRLVNGTLVSPHTPISDASLALSQMSTPDLHDPLYSPALSVGTRASSVTSTPLSPERHGHSRPTIRIVNGDADEDGRHRGQSRSVEDVLDSQAAHNKIDSPGQKSLYILPVPPRGDYPANDILSPTTAHHPNHAVPNNLPLSVRTDAQPTRRAPPTLSLDLAAAANASRPGVPKLAPVVVPSPSTLRTSATGQPLHVTTDELPSAFSPDSMTSSSRSGSMSSISKTPLSAYSQTADSSLVRSHSGRRFGAGQTRSERRASHRRVCSDTIRVPTTLGFTSASSPITPLSGVNGSASPRSTTPLSEMTRAEEQGRSETLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B130</accession>
    <name>A0A2S5B130_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B130"/>
    <dbReference type="STRING" id="741276.A0A2S5B130"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="9">
        <location>
            <begin position="183"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="431" mass="47637" checksum="7515ED2A1EF32187" modified="2018-07-18" version="1">MRIAYLNVDGLERFILAKGRTLKSWLDSLGADVVALAEVKIKSKRNKKLLNLPRSLCEVQGWDVYETLPSWVDSERGALFGMVAYVRCATLKPSKAEKSLMLGKRNKELKKRDRIGSYATFQELNITEALSNKVDGEGRNLVIDLGILVLIFVYMPNLTQKDQYTSRRQAKVLATVHRAAVEGRARELIKAGRSVLIMGDFNFPPTEDDGRLSDKCKTDGQAWYANIASPTDLGLVDLYKYFLPGTRGRTYFGRQTGQTESPGTRIDLSLASPDLLPLILNAGIDSTECDSDHRLIYVDFGASAQFPGSNPADKTRSRPRIVLDLEERLRQQSGIASAVPKRRDSAGQSHQASANKPKTKPSKERGPRRMGLPHVSSRKVPPTVCPVLDLTGDSSDEAGRPLIIPAKRKSRSTKASSESSSTPLKKKGRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B171</accession>
    <name>A0A2S5B171_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B171"/>
    <dbReference type="STRING" id="741276.A0A2S5B171"/>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15238">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L39, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15238:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6537" checksum="7FF86073121D5593" modified="2018-07-18" version="1">MAKAKSRLVVVRLLSTVGTGFAYIARRPRTAEKKLAFMKFDPKAGRHVLFTEAKLKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B196</accession>
    <name>A0A2S5B196_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B196"/>
    <dbReference type="STRING" id="741276.A0A2S5B196"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="228"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="549" mass="59551" checksum="02D0A498CA3B63F2" modified="2018-07-18" version="1">MVASWQSTVETSRNALEAKLKATGFAGQVGHIGEDVLNVTSVPFDRVLTAREIEITELGVGQLLAKLSGGELTSEELTRAFLHRAVIAHELTNCLTDIFFDKAIARAQSVDAEYAKTGKPVGALHGLPISLKNQINIEGEEMNLCYVGWTGRISNVDSALVKCLLQQGAVLYSYTNMPQALFSGETICNLHGRTVNPHNRALAVGGSSGGEGALVAMHGSPLGVGSDIGGSVRIPCAFNGLYGLRPSYDRIPYGSSSNSMEGFSIVPSVLGPMSTSLDGVKAFFRAVVDAEPWRYDPLALHMPWSESAYALKEHGDGKELCFGLVRHNGMVKPDVPYVRALEMLKAALLAQGHKVIDYVPPQTAKGADILTRLFQADGGEDLKRECATSGEPRLGGIFKGQAVPPAISTYEFWQLCAERRDYIAMQLASWEATRDQTGTGRPVDALLCPPAPYPSFRHDDKQDIFYTGICNLCDWPAAVFPVTKVDPAVDKPVERTDFLSDFDRLNHERYDATVYKDIPVSMQLIGRKGEDEAVIRMMEIAVAALKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1G4</accession>
    <name>A0A2S5B1G4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1G4"/>
    <dbReference type="STRING" id="741276.A0A2S5B1G4"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="63" mass="6954" checksum="B44FAB6AFD01313F" modified="2018-07-18" version="1" fragment="single">MTVDDLRAVWDGMNSDLGNDPKKFTFGGFKRTGKDGTGPFRDEDIVKTLTNATDWIAGAFKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2B6</accession>
    <name>A0A2S5B2B6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2B6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="90" mass="9590" checksum="EA992FC970593427" modified="2018-07-18" version="1">MLSRQSALAQRVARSSQSHRLGRVTYATMPGGTGGIGGKAADQNQRNLLMLGGGALAALGVYYYTKSSPDARKEYEHIKEGVKQHPGSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2I6</accession>
    <name>A0A2S5B2I6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome maturation factor UMP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000091">
        <property type="protein sequence ID" value="POY70987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2I6"/>
    <dbReference type="STRING" id="741276.A0A2S5B2I6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16724" checksum="DE1AC43384193FA6" modified="2018-07-18" version="1">MDPSLHLVPSGQPTHDHVSLATTASSLGPHDALAHGGPRSIAAEVASKHPLQNRLAQWDATRDNLHMTLERNMYGLHAPIRLEMERQLVQSAPTPLSLGLPGAGFTRPGNLALEILTGRDEEIRPEDVLIDRVQTAPLGDFHRQMERKFRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2P7</accession>
    <name>A0A2S5B2P7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000093">
        <property type="protein sequence ID" value="POY70961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2P7"/>
    <dbReference type="STRING" id="741276.A0A2S5B2P7"/>
    <dbReference type="OrthoDB" id="2524557at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="75"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="490" mass="53210" checksum="735CBE44E1B41797" modified="2018-07-18" version="1">MQTPQSHPPSTLLQPSRPTIATQSSESNAFSSAGLDGVSAPAPSVSPQTGSSTDPARPHLVSVLPTFSRYAPLRGTVRIKVEDAVFYCHREVLALASPFFAGVLGGGWRETQTLPSPVQAAHQRCSGDATPLVRESDRPSLVPDPATCLPDEPYAGATLAASTGSLRSSHDAGSIYTTVTCSSVVEDSDADDDPLDATFVDCRLRIHEESASSFQDLLCHVYPRLECAIHWSNAEDLCRMGLKFDIPSLTNACLAFLLPSAAGRPALCMKIAEEFGIPTLYREGSRYLLDNHGGWTSEELAILDPMTLLKLERKRSWFLERLLKLGQIQMLRDYACHPACDDQSRCARLVDEKWRSAFSSAFRFGTPQPSIIYRSLRSLEPSLSSPALHLPFTACQTHAKLYVADLFDRMFGLGIQPARNWSSLALNGTSASASPGSGNWASLRAGAGDTVHSQKNNSARYFLCVELRDESTATGNGQDRARDFNRSALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2P8</accession>
    <name>A0A2S5B2P8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5952</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2P8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2P8"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cux N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="12">
        <location>
            <begin position="424"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="108"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="236"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="505"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="661" mass="75276" checksum="AB9FF1FC02596166" modified="2018-07-18" version="1">MADTSFATALTVWKDIALHDLQRTLDQQGLEIVDNQKENTFKKVPDEEKGPAFKTLLKAYQTEIDNLTRRSKVAESAFLNVYKLLAEAPDPFPLLDAAVDQTARASEAKLLEADLARSKEENAALKQQLADAQTVEKERKKLADKVERLEGRMEDMIGERVAAKEAALHATYDERLRNYDEREKDLQRQVTLARSQLRELRTTADTSQARLLDHSQRQDQETIARLAEADLVAADLERATARVAEVEGRNEKLRAEIEAVRSGSESTMRVETLESQVSDLQNEASRLMRSLESQKEQFDKERIDLRKSVEVLEKEQMTKEAELASLRDKMRQYQDYDELKRELEIMKYVEFAGMDLDADETGDHDGEGDDSLVRLPDPNADKANLHRGKPLENLLMAKNRKLQDEVTALRVAHDELALTHEATAAECEALQVRLQEQVALADRLENDLLRINDSRQGGQTQTSAANREDPLANLQLGKKDAPAAQPQPFQSSADTSILPIITSQRDRFRQRNSELEEELRRQFNTISELRNEIKTLQADNLKLYEKVRYLQSYRDDGAVARAQSGFSNVVRGDEELVRYQNKYEESMNPFEAFRGRERGRAMHNLNPLEKVLLTLSTVVLSNRVSRNLFVLYALGLHFFVLSTLYQYTLTSEAAHPVVPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2W0</accession>
    <name>A0A2S5B2W0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2W0"/>
    <dbReference type="STRING" id="741276.A0A2S5B2W0"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="53"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY71021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="547" mass="60628" checksum="12AB0414051FFBC4" modified="2018-07-18" version="1">MSHSDKDLKHMQDMHMEKAASSIEDGDTPLASAPGSHLSLLEALKIWRFGIGWSVILSFAVIMESYDTILLNSLYAAPAFQRQFGVRQHNGKYLIPAAWQSALGSGTTAALIIGIFLGAPLIDRFGSRKCMIGGLIWNFAFGFLIFFSKNLHHLLAGNVLCGLPWGLFAVTAVAYAVEVVPTQLRNYMSSYVFERLILEPSTINLCWVMGHLVGAGVLKASVQYNTEWTYKLPFLLILIPPVPLAVALYFAPESPYYLARKGRLEEATAAMDRLHAEHASVSSHELVEQIAETNRLENEMKTGGTWAACFRGINLRRTEIAIVSWTSPALVGFVFQFFTTFFFTRAGFAADRAFALGLGNYAIAFVGTVFSWFVQARLGRRTIILYGYCFMLPLTTLVATLDFAKSTTAHWAQASFVMAYFFAYGSSQGPVPYVIASESSAIKLRAKTLALARVVYYVASIASTTLAPYMFQTWDLKGKAAFPAAGMTLLLLIWSYFRLPEMKGRSFEELDILFALRVPARGFSSYVITEADKAEVSARVEERTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2X0</accession>
    <name>A0A2S5B2X0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2X0"/>
    <dbReference type="STRING" id="741276.A0A2S5B2X0"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="174"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="452"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="507" mass="55486" checksum="8BDB784038DDA960" modified="2018-07-18" version="1">MSNAGRFIPNREGIDLATSYSLLPSSTSTSGSSTPSSNHRSKRKTANVDSDAQTEEANKTFDSLLRTELFGPSSLDNIPLLRSPSSARTSQYTAATSPGGGGGGHSPSHPKALFSFTSPTRKRIARDPTVTDRGLDSPTHERYSLSPVRQESQRLLMSPRKPVRQVSKVPFKVLDAPELADDYYLNLVDWSSNNVLGVGLGSSVYTWSAQTSEVKKLCDLAEADPPDSVTSLAWVQRGNQVAVGTKNGMIQIWDAQAGRCIRKMTGHTARVGALAWNDHVLTSGSHDRLIYHRDVRIKDHWTHKLAVHRQEVCGLKWSDDNQLASGGNDNKLFVFDKMSETPLHRFTDHIAAVKAIAWNPHQHGILASGGGTADQKLRFWNTLTGNLLQEVNTGSQVCNMLFSKNSNELVTTHGFSAGQAQNQVVIWKYPSMQQVAQLAGHTFRPPMADADRTPDPNQVLYLACSPDGQTIVTGAGDETLRFWNAFPKGKTERKIESSILSPFGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2X3</accession>
    <name>A0A2S5B2X3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CEF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor cef1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5895</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2X3"/>
    <dbReference type="STRING" id="741276.A0A2S5B2X3"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="781"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="838" mass="93866" checksum="618D95FA3FE5C25C" modified="2018-07-18" version="1">MKIVIKGGVWKNTEDEILKAAISKYGKNQWARISSLLVRKTPKQCKARWMEWLDPAIKKTEWSKEEDEKLLHLAKLMPTQWRTIAPIVGRTANQCLERYQKLLDEAERAENEELGLAGVDDAGPSADDVRRLRPGEVDPDPENRPARPDPIDMDEDEKEMLSEARARLANTQGKKAKRKVRERQLEEARRLAILQKKRELKAAGILMRAKPKKNGMDYMADIPFEKQPAAGFYDTSDEKAKRVAAPTGKSLRDLEIQNRRKDRETAEAKDKKRKAQSKDANADAMSHFVPSKDALLQQRREEQQISKRRKLVLPGPQVSERELEDLVKIGRAGESARAMVDENGNEASQGLLGEYSALGNARDARTPRTAPQHDNVMAEARNLRNLTAQQTPLLGEENTPMRELVGRSGFEGATPAGQVAATPNPLATPFRSGQSDVSMTPASSVGATPLRTPMRDSLSINDENASIYGATPREDRHRLNDVKRQLRAGFSSLPQPKNEYELVLPEEQEEVEAAGESAEVAAALRIEDRSEREARLKELRDKEEKAELERRSQAVKRGLPRPAEVDAAALLAQLDLEAKDADALQEDKWRREAERAVTAEMIRLLEHDSIAHPVAGSKRAGGGKSALPRIADDELAAARKVVHDEIAQSVGLPGASEKTLRRTVALSAEDFEKSWRPSYERLAFDARTNRYVEKESLSDADRIAGFRALIEANRDKMASESAKAAKVEKRLGQTLGGYVARSKALAGKLTENYDELARTRIELESFARLAANEEGAIVRRTESLRDEVERLERKERDSQARFKEMLDLKDALERDVQELELEEAERINEQALASMEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B330</accession>
    <name>A0A2S5B330_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_5504</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B330"/>
    <dbReference type="STRING" id="741276.A0A2S5B330"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="19">
        <location>
            <begin position="54"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY71193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="495" mass="54132" checksum="AC1F8AEAE80836F1" modified="2018-07-18" version="1">MASAPTPTPHLERFWQPPPPSTARLPNLRSTVASWKSPSLRISRVAQLDAALLDDELENILHAPVSAVLDGVKASGGRSGQPEFMALLRLVVLKLSLWESSATYGASLQNLRYRNEGGHTPGQDWPSLPFFVHTSTDTFHLALGGHGADSSLSRLQKSAYTALVVLPPYLQARLQDRMVDTSWADEPLPRSWFSLVDLRRLRHRGRRREDEIATWKREWKRAAWELLSAGERLGAIFGLLNLLIFLYNGKFRTVVDRILKMRLVYARRAFSPNVSFEFLNRQLVWEAFTEFLLFLLPLINLHRFRLRMAKMISSRAKKSSVLRATASVLPLPVANTLGLASLRSSGADAKARQDGNAAAPGPYAFLPPHTCPICYSTSTGPPAGLGSASAATAFADPTLPSASLLHSSSGPGGAGDTAVKIPYVANCRGACRYCYYCIVGTLVRAEEDAEDSWTCLRCGDEVTGAVREEPTPVDVAEAEDGAVAEEDHDEEGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B335</accession>
    <name>A0A2S5B335_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B335"/>
    <dbReference type="OrthoDB" id="10641418at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="351" mass="38555" checksum="11C9EC14C482A7F1" modified="2018-07-18" version="1">MLAPAPVEVAQTPPQPGPSKPRSVPSPTSAETSAESSADSTAPRGAAAARDTRRDHGKKHVAPEKRTQLGKLRCRPPPPPPPAPPPHAAALPFLLARHPRLPLIPPATNNPTNGARTRSPSLSLTPIPDTPPVPDSVVSVDVDEGPTSSDELEARWADLWPAVADQPHLASSDTELVDDSDRQFRPSRNPNNFRVRSFDPDLAMRPFQPWTVTQACMYPMEARPNRQTLPNPYDRGPMRRAEAAQVSNEARLAAERSARKRRRNASPSTADSQARRQRTAKLDASRRAQEDDMLRRLVRFEENLENPAASDSDSDYVLSDDVSQPTVGFLAVARRVLRTNRQERRRGGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B386</accession>
    <name>A0A2S5B386_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B386"/>
    <dbReference type="STRING" id="741276.A0A2S5B386"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="63" mass="7196" checksum="4BF3CC8780EACB31" modified="2018-07-18" version="1">MLDALVYRPNTIKQRQAQFQADPRHVFQKVPRARLYMIGFMSLFTVGTVGIAHGAYRMALGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B397</accession>
    <name>A0A2S5B397_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B397"/>
    <dbReference type="STRING" id="741276.A0A2S5B397"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="274" mass="29555" checksum="FD2AD88BE41716F1" modified="2018-07-18" version="1">MSMWDEETIEPHIDKYLALRLEGNEKLVKGDLQGALQTYHTVLLALKGLEGPLQQIYGLPAPPPVNQVSEGTDEEAKAFAEEGEAEKKKEKELTKADLVKEAILNTYLNLANIYIKQEKWKKATEAAESAKRLHPDHPKAIYREAQGHIGLGEIQKGREMLVKLQKKNPDSAIVAALQKLELDEKNRQTKANAQMRGMFAGMFASKPAADASKGKGSASSDDGGKIVELADDKVEGQGEAATKAATPPEKIGEGADVVDETKGSPATKASTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3H4</accession>
    <name>A0A2S5B3H4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3H4"/>
    <dbReference type="STRING" id="741276.A0A2S5B3H4"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="926" mass="99566" checksum="52374B43458FA5C6" modified="2018-07-18" version="1">MPVTAGPSEPRSSSDLPRGGSPSPRSLAARTFANLTRSASVRSNVVPSLLAEAAAEHAKEDTPLRLLYGPKSEGNGPPYAASALGVSGLAIQTITPSLSCARHAEPLCGAVLDDRYLLIGTSSGLDFLPLPINNDDSPAGGGKRCATRKPLSIIKRTRFKEICLLNERSNILVAIAGRNDHVRVYPLDSIRQMIRRRMQDVDANQGYPIASASDNVPFDANRIARADRDAGHSKPPPVQISPKPRPQHADPVRTVGIVSHVAEPSGASRRALRSRASRDFIAGRRPSASSAITPSSRSRAGTASASSRRSSVASGQRTGTPAPGEVTQHPPHSPSPDLHASMRPPLEPRAPLRLLNASERSSTSCLADFLRDTGPECPPAEFAKNSGPESSSANAASASAARRLRLDDMDCGPAHEPLDRTNNSPQAYSESSSTDLEPWQVAPPALPAATGIDSLAPPAVSARVRKRWTFNGFTTTASPTGDLALAAGDRTIPSPTEQSEAIPANSSRRYDAPHGTVAQDYVVDTSEQVSPTRDQLSPTLRKRRSVCSLPDRTDRRALEKHDKHAVNLYPASQSTASLEFLKLARSRNAQLVRAIETRKKTYLAILGGEEGDRIELYTGSKQISLSLNRTFVLPDAPRSIELQLQGDDLVDIYLIYADSIFALEPATVRVREVGIGRDERRSRQRQRDEEDSREPSVLESRPRTSSQRVRRRSTADEPPSYPQPASESRENDSRVKRDFSGFQQLAFIPPVPSHILAPSWIIPPLYTDVMGDGEPPLLSPVSLLSGAALRNNGRPGLFFCSTGAHSTAIVTAEGRNVIGLPLRWNAASSSAAAEDDFLRHRLETLVLGGAKTVVVRIASDSLQIANFACLGNAGDGFIPASTVPAPAHARFTSLATYAAGEQLFYVEATASSFSIKCLHSLDWARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3I6</accession>
    <name>A0A2S5B3I6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3I6"/>
    <dbReference type="STRING" id="741276.A0A2S5B3I6"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="116"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="358" mass="38163" checksum="F260F59F0CFAC75B" modified="2018-07-18" version="1">MTFDFAAFRDAAEAKNASMLTGLDIRGVKAVIDEHAPPVVRKPKAKRPSVPKPVAARVVDDEADERERRGLRSSSRIKDQLTGSKATPTPSAASSGPFIDDEGEEEAYYYENGQATAMPGIPVGSIFQSRLDASQASIHAPPVTGIATGKVIGEKAACASICVSGGYVGDVDLGERLTFSGAGGRDLRGTKAQPKNLRTAPQSCDQTWETALNSALRRSVDLGKPIRVLRGFANKGPFAPVTGYRYDGLYQAVRAFEDTSEDGLLICRVALVRLPGQPPLPVHPDREHMLQGTTLPTSVDDSTSGAMSRTSSSSSSAQSVSTKATTPEREDAEESAPKPEEDPSGPSPKRRRVSQRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B431</accession>
    <name>A0A2S5B431_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000083">
        <property type="protein sequence ID" value="POY71544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2526884at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="949"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1348" mass="144146" checksum="12C171FC8D804923" modified="2018-07-18" version="1">MSETPRQNAQASRLARRQSPYTRVSAPATPAPSTPSRLRTLLSYISPFRSARKPAETATPAIESQPNDEEHDEAAAPTPLDERDWDEPQASSNSTSRTVNTPLPLRLSGENNGNATADLARFFQDKAREGGAPLTPIERAGVLQLLQEGGEPQTPTAFTPNFRPEAGPSDAATSMPATSTEPSDSLPTTTRRRPLYVGAGYTARRRRQARQVTAEEGDAHAQAAAPAGKRRRLLEEADRSAAVLSFPRASPSSGSSARAAAFPASASRGPDGLGQRTDPSKPSASRSDASPKRVTSRAADLMLDIIRSEDSGSSRSSGRQAPRPADTARILNPYDTAEDPLSFVSRSPRSAVPVKPPMPATRQTPSQAKPAEVVRAPEKPAPKPATPIEILQRTMPAEYRREAMKPAPKSRQPSPPRPTVKPPAAKASKPDTIELLSSSDGEDEGEEDVPEGGDEQEAAGTTTEEDEAATEEDELEQFSARSDEGDVDSVDMAMDDAAGETTRSGTEEAATETDGEPEIMVVDSDEEEETPVPTAPSQVQQPVSSRPQPAFSFGAAPAAKPTAFSFAPALSTAPASSVAPASSVAPALSAALGPADTTAEAAADSMDSSASGADNSADPVAAREAALHLVKAQLPLSLFAFTTAFSPSQVDLATTSIAELDRAAGQQYDDRAGTPCTTPGPTLAARIANLDLAGLTVIPITRLPRLRKRVRVWHRTVTIYADLTASELVFRRLRVGQVTTRSRDVGREPIQVTADGVEIDLTGSIGIRAGFYYEDDDVKNLGEKGAGGHEGRRGWSCRGSGRVHVALNDASTLVTTRLVRRPVSPKCEHAESRPGLQCREIEFSPGSISLLSLSGFVPFLRLEALAHYFRNTPLARAATRRFAAFMVTEVLHGPVCSDSLRDLEHFIEKHVDLETWSTVADAERDEVLKRFFNDSVTAGHSGETLNDGSTAQFTTSTSPTTKSTSLRLHALIYGSLHLHSFALPVATDGVDADGTTQVPVFARRDQTGLRYSLLSNPILNQLTRGPPDVSFGPSTFEKVAFREASIELEPDPIEVLEGNLGLASPPPPAATNSRPSDPASSTPAAPARTRARELVLRVNGLVANLSIGFRIGAELRRAPALVSGMRILEEKGVATTEIAEAVTELGRGKRQWAQEKRNRTTTDEYVDEETEGEREGSLSAAPEAEEGIAIRLPLRWDRTTGRVYLTSRHDDDNDDLAVVPDRPGSIAALTNSHRRQGSRGGPNARGIRLEGTFGTVAPRVRLESRLGKLLGERVVNALLEGVQTHLAALTIPLASHFLADLARQRLQRALDSVSERLATEGGVLWTPAAELERTPEQEATRIGHEKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B478</accession>
    <name>A0A2S5B478_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5408</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B478"/>
    <dbReference type="STRING" id="741276.A0A2S5B478"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="322"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="490" mass="52875" checksum="AEB020DB0C4292F4" modified="2018-07-18" version="1">MTAHSANTPAGSSPSAATSSSRRRLSNRRLRPEGEGQSSREASAESNDETSSPSLLEDDDDDDNVSLSAPRTRSAVPAPGPASASRPATSGLGQQLGELHLGDVTPQQLDSATPAARSLASSTQLTPGAAAAAGEVTEGYDSAHDGDVSSATAGSSSVSAARLATHPHAFRAPVSLHPSSLSHPHPNPHSHPHSLPLHPHFQQTSSFRSSASETLAGKREDDEEEEDDGYSPSPPSQTETETDGEPLSSAAGKSKSRAIPSTYPERRPEQAEPVLWAPAPSGFLSSMTAEDIQAHIRRAIEGDPGRSYKIKAPPTDRPVRIYADGVYDLLHYGHMLQLRQCKLMFPSVYLLVGVCSSALVEQHKSHPVFSSEERYESMRHIRWVDEVIEEAPWQVDQEFIDKWQIDYIAHDEEPYASAGKEDVYAFAKSIGSFLPTKRTNGISTSELLQRIVEGYREGEYDSKLRKIGHPELCSQPASVKGEPSVKAESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B519</accession>
    <name>A0A2S5B519_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BMF94_5234</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B519"/>
    <dbReference type="STRING" id="741276.A0A2S5B519"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="24">
        <location>
            <begin position="472"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="23">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="23">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="POY71873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="805" mass="86247" checksum="82C5D389CD638ADC" modified="2018-07-18" version="1">MFTSYSPSPSPAPASPPPNSHLYSPGAANHANSPSGNHSNGTGGGAGSGQGQPQASNSGQSHAAQQQRYSLLSKLQQAPHGHYGQHHFSFGGPPGSPAYPDGPQFRHGGASLASHSPHHPSPHAPNGVLQGGPPPQLQHHHLSGVGQGGSNGNGSGAGGNNSANSVGSPLPLSNGGPIPPHWATQLQLAQTSRATNSPHHHARAAHLAARGQTTNAIPITDPNRPGSGAGPAGGSLMLGRVNGIAGRKDASGGAAEEQQPRSGSAASIRTTLTPARTGGGGAAAEATSPSISAAGTDAVEAKDKDRGRTTWTTIDMGGMNLKNLSPALFRYDFLTTLYIPHNSLTELPPAICKLANLTLLDASSNKLTSLPAELGLLTHLRELFLFDNHLSNLPPQLGTLHLLETLGIEGNPLPDTLRSLIEKDGTSALISYLRDSCPVPPPPPERSWLTIEPEALPSADKRPEDSFSILCYNILCDKYATSQMYGYTPSWALSWEYRKELILQEVLNYGSDVICLQEVDVEAYESYFMEHLSAQGYDGVHHAKSRSRTMSGDEKRAVDGCATFYKSSVFALVEQHLVEFNQIALRRPDFKKTEDMFNRVMTKDNIAVVTLLEHRASGARLIVTNAHIHWDPEFRDVKLVQVAMLMEELNKIANDFARLPARMNLAEGYDKAPHYSTGSKIPTVICGDFNSEPDSGVYEFMSSGRVEKDHDDFMDHVYGDYAVRGASHNFKLKSAYSHVNELPFTNFTPGFTGAIDYIWYTAPSLGVQGLLGDLDPEYLSTTVGFPNCHFPSDHIPIMSALKFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B580</accession>
    <name>A0A2S5B580_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000064">
        <property type="protein sequence ID" value="POY71942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B580"/>
    <dbReference type="OrthoDB" id="10314589at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="102" mass="10873" checksum="F04C6C85D677B9B3" modified="2018-07-18" version="1">MVLRSLTLVAKPVMLRAAAASTSASAAAAHDLARLAPHQQIPFSMAPTPKVEGLAAVSFPDMHALEPVYAQATLIRCWESAEPRTTARTNEYRGPVEGFSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5H0</accession>
    <name>A0A2S5B5H0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000061">
        <property type="protein sequence ID" value="POY72029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5H0"/>
    <dbReference type="STRING" id="741276.A0A2S5B5H0"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0117">Actin capping</keyword>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="48169" checksum="059F3B8259BFD9FC" modified="2018-07-18" version="1">MSSSNQAKLDAACTFLLQSPPGELHDVLADLRAILSPSGLSDAEIETGLLPALQQFHETQFTPVQLAAADSNHKALVTPANKLQEGEFVEPRTGTVFSFDHVKETASPAPSTTSYTTPLDTETESARSALDKLLSTHIANHYTSGVSAVYVLPDPEFPPPPPTPTPQEPAVEPEQKKEEETAPATLTETEVKPSVSIEEEPGAAAEAAPKPEDSAAAGEPDSLARGVEGSAEAVAETAAEVAQVAEEVLEPEGVETANGESAVPADNDHETGTRLEAGEAAATEDDKMDVASPAPVVETAQEESAPAPAAPAPPKPRPSNQFGLYFVGSKYSPNNYWTGRWRSTYSLDQAKGTLQGTAQVNIHYYEQGNVQLSTTFKSTSDLGATPLPEAVVASIKSSESSFQRQLGETYGELSDATFRNLRRALPKTRSKLDWDRAAGYKLGRELGGGGSSGATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B659</accession>
    <name>A0A2S5B659_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B659"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37378" checksum="232EEA0C90DF0C0D" modified="2018-07-18" version="1">MPIRCKKVSMSADGRSPVNSIEVLALYGPHVRELDIVVPTFYAFSQDVLGALATALPACVRLEAFTFRLSGGYSVCLQSFLDAFTSIGPKLRHLDLQLNWQDASLVEAARHCLAHAKDVVSLSVRLESVPSSRAIGDPDFPPLRGSDRLIELHIPSRAYLPAGSTAPALRKLHIEFFDRSDLTRLASVLGDSLESLVFDLWTSEAPIFAEPKILLPKLHAVQYNSVRLPTFFFTDVLHADTPLETVHLRGKLLFDCPETIYGLQRLLLKQTRRVLKRVTIAETCGTDHQFGADEETACTVGALSQIKEVFDTSFSAAHEWAKDEGIEMVVALTHGLTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B668</accession>
    <name>A0A2S5B668_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B668"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="412" mass="46602" checksum="4B69BD6FABBEB2EE" modified="2018-07-18" version="1">MDALTMPSPLSTLPPPPFLRLPDEIIEHIAGFLPAVSYPRNEKDENVGLSLQRLACTNWRLRNVVLPLSWKRIVLTQAVRRAPDLHRHLGRYGRHVRAIQVDYLDIRDVIEHVEDEPNELVAAVASWLPYCPDLTSFACLLVTKRATDPTPALQSLAHSSRCLEQLHLRGFYWSTASFEALNDLVKSAAALETLKIETRTFRENDDPLLARVIPLPASLDSLRALDFPHSRCIHNWSADTAPKIETLTFRVLAATDWTRLHECLGGSLKSLSFHKIVQAPGLDPLFFKDLRTVAIEASPGSVVFANLFAPDTPIERITLLYFDDELIANIQDFVMRQPTPTVKSITVTGSRSYDGYLEWFYSHLLGHRTAREQEEIDRRHAVFVAETQQKLVEYREWADAHGIVFTAKDASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6K4</accession>
    <name>A0A2S5B6K4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000049">
        <property type="protein sequence ID" value="POY72410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6K4"/>
    <dbReference type="OrthoDB" id="2527173at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="641" mass="68100" checksum="909EA3522DF4A8FE" modified="2018-07-18" version="1">MSLDSITLVEATSGSVSPSEHVDIEPAVPLCARDDVAGPLTVQSVFVEALEDPTSPIPSRDELETHGLFDLSESERLLAEYRLLHPSPLSSPVVAQRVRAEADERDRPKRQSSDPQGRYSLSVLQLPPYWPTTSPLTSPSDSPRLNPFAFGRKSMVRPRPNHTKSASEIPLASGAASPLEDLTNDRESATSALYTVSQSLARGETLKAEKRGVRKLRKAPPPRISVRTDDSTLLRPEAALPDYRSTRSGYSGTDGSEKERRMSWHSAASSSRQSRSPLTYEPEDLQTLSMPQSPSHGADMASQRRPLSIALNYKRREATSTSADSAYYADSERHRACSTRSSFGVASSPTSSVSSPSRWSRPWGFDRLKRAGSSTPASPVVGPGGDGDAHDPLSADLVRFQVLSRPSPRLSMSNDCPASAGGHVAGDARGDRTTPDDVLLLALDSPSLKHESHFPRIDSPRPGAGTQRRTLARGISYDSMHTPSGCHTPAVVSTASSGTIRAPDLTGMGGFAGGDEGEGASNRAKLPEGLSALMLSDPSADGASANDDHPGASEYSQPQRADSRKRATPPSFGGSSSSSQRSRSRSRDSMSGLSGDETPASSAVEGDDGYGLASQDEDQVDTAKSMSAFVPPEEVAVTPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6U3</accession>
    <name>A0A2S5B6U3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6U3"/>
    <dbReference type="OrthoDB" id="2505950at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="130" mass="14327" checksum="7CA73F1A96D1647E" modified="2018-07-18" version="1">MAKSTAPTDEGKPWFRLVVTVAVLAGLAYMIRLVVKAINEGVDSAKGTLQQKGVNVSTTGASIRTDKRAVTQEELGDQMQRGLMKGWKASTFNVPWALTKTTHLGGSRHDKNKEEWEKANGPKQYKNRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B795</accession>
    <name>A0A2S5B795_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B795"/>
    <dbReference type="OrthoDB" id="3364747at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="174" mass="19424" checksum="59075B1ED58FCA55" modified="2018-07-18" version="1">MSTVATHPAGEPAYVPTTTSAPPEHAVPSPRDSLDPKVIKEREKQQKHLEKDLSKEAKRDDKALKSTMKDADKQAKAEKKALAAEGKSRKKLEKISQKEQKYKAGLEKAQRKYNDELAKLEKARADLDAKTREREAIVQQRQPAQAAVEQQKQAKAVHDATREERINNGPAANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7A5</accession>
    <name>A0A2S5B7A5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_4476</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7A5"/>
    <dbReference type="STRING" id="741276.A0A2S5B7A5"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="13">
        <location>
            <begin position="15"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="14">
        <location>
            <begin position="264"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="151"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY72648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="459" mass="53468" checksum="AAA9E9AD9DE7E881" modified="2018-07-18" version="1">MVPAPAMQSSAQIVTFPVLDAPALLTDTASIGCPLQPDDLSHPQPARILALYEWWMSRLLQLQAEDIKRAAEAQLDQLEHPEIYREAMYLGVFTIALNQLLIPSGVHDFTVRDLTLPRPDRLRYILSAVINFYFFAEEQGERVLRPLQDEMTELAQEEVALIEENQKLRDRIEEETARRLENQAKMAAYRPEEERNTEMMKAAHRAIDDHGAQKRALKLDCEELRRRLTDLQQENSNIDLAIMDLRGQIISSPEKLRGKIDEMQDQLNREKEMFQETEVKERQTQSKINALTQYSQELNSCIRILDDWSVDVDKLRDAELRLGEHEDHLRNLEAEQSDLKDRIELLERRISNGREELTRMKDKMERKREAAKGRKRDLELQHAASVEEKRHLDDEAFKKNLEAQAVEQHIRDMYASLNTELDKGEKAFKRIKEQITLYSIRLNKALDSINELNALDPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7B4</accession>
    <name>A0A2S5B7B4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7B4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="170" mass="18884" checksum="A8AB29F899CCF6FA" modified="2018-07-18" version="1">MSDPVLYRRPPGRHLTNGAAETALQQAVGAWNLARKALSSWALQRGMHAGSASLVEAWQTRQRQLEAHVEETTDALRNIVDSSDDDSVQEAYRRAHAQCAALANALQSPSLEPAQRTVYQQGKADAVALRDFLSPFVLSIHNGQRQTRSLGNVHRKMAGNFRRRHIYGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7C0</accession>
    <name>A0A2S5B7C0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7C0"/>
    <dbReference type="STRING" id="741276.A0A2S5B7C0"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="275"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="366" mass="37790" checksum="39F006B393244465" modified="2018-07-18" version="1">MHNALFEQLAPSPGTTPANGPAVDRSDVALSFPCDSNALQAQLEAWTNVAFDFDSPASDDVPLSSATSPRAADKHLHDAFSANRTHDFAGFSSTVAPGLFADAPSSAVDLTAFLGNSSVSNSATTSLVDPALSLPSFAQSGLALPDAFFVAPGVTGLTGQDEPATLSPADMSTASVETAAAPSPARTSRAAGKKVASGPARKKRASSSAASATPVAVAVAVAPAAPVASTSSAAASTSSEASTPAAGKAIALPLPEGIDTKGLNDEELNRLAIEEDKRRRNTAASARFRVKKKQREQALEEEAKKLRERVAVLEKEVDTLKTENGWLRGLITDKHIDVGMSGADNNRKRRRVDGEPTVLDPSALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7E8</accession>
    <name>A0A2S5B7E8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7E8"/>
    <dbReference type="STRING" id="741276.A0A2S5B7E8"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="54166" checksum="48035BD814B4613B" modified="2018-07-18" version="1">MSRLGRASSGVSALLNCLTAGAPFIFPIWAPEVARVTGTSSAHLQLVATAAILGEYASAALFGALADRRGPGAVSTTAGILFGVGLGALAWRYQVCAVEQANGVTPWVHEWVLLALAWFTVGCGTAASYFSAMCSLSKSAPASHAGLAIALPCAVFGLSPLFLSTIASFFTTSIVASEETSALDVRAYLGFLGALLMAVNLAGGFLIRDLPWADDNIDRAIVAVIEPFPDYDDGSGYASPAELANERTPLVRNRTGEPDKSDEAATGESFRAFVSTTSFWLLGGVIFFATGPAEMYMASVSQILTSLARPDLSLPSRRGSQHGTLTLSKHHVALLSISNTIWRLVVGAASDYLARPDATGRKRTGWRKHIRLVFVGAACILLALACLWAATGMSSPAGLWVVTPAIAISYGTIFTLAPALIRARWSILDFGRNWGTLTWFSAAGAMLYTPLYGILLDLARAKQDDSEERNGVCVGPRCYRPIFALLTVSAVVAGALVIVLGRRWARRRIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7I0</accession>
    <name>A0A2S5B7I0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_4140</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7I0"/>
    <dbReference type="STRING" id="741276.A0A2S5B7I0"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY72733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="125" mass="14477" checksum="BAD2DEE1889EEFAD" modified="2018-07-18" version="1">MASITFCKECNNLLYPREDKVHHVLLYACRNCQYEEETHNPCVYKHDLIVAAKETAGVTQDLETDPTLPRSNIQCPRCGHQESVFFGDQGRRAQTSMTLFYNCTNCHRTFLDPKLTQRRKEQAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7I7</accession>
    <name>A0A2S5B7I7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7I7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7I7"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="502" mass="56046" checksum="7BA6CF35F8694E35" modified="2018-07-18" version="1">MSKMSDVERNPTIDDEKYRIDHVEKADVVAEGGIQPPARIFTPEEEDKLYRKVDFRIMPILSLLYLLSFMDRGNIGNARLEGLEKELKMNSQEFNTTLSCFFITYCLCEVPANLIMKKFRRPSHWLGLVTTTWAIVMTLMGVVQSYGGLLAARLALGVAEAGLFPGVILYLSIWYPRHRSQSRVAFFFGAATLAGAFSGLLAYGIGFMGGVGGYAGWRWIFILEGLMTLVAGIGSFWAISDYPADCKWLTKEEADWLIYRKAIDSGVHGESEVVSWKYVRQALTDWQTYLNVGYYLGVVVPLYAISLISPTLIAGFGKFTRPQVQLLTIPYYSVACIFVVVTSIMADRQKTRFRWMMIDLLLCFFGLIIQLTPAPYGVKYFGIFLIACGAYGGLPTSVTWATNNLSGQTKRAIGSAFQIGIGNLGALASSNVYRTQDKPKYTLGHSVILAFNVLGLVAAPTYAYLLKRANARKLIEQQSGREYTVEEIHELGDKAPHFMYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7R3</accession>
    <name>A0A2S5B7R3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7R3"/>
    <dbReference type="OrthoDB" id="2527504at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015708406" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="43903" checksum="F35A9682FA86739F" modified="2018-07-18" version="1">MVRLVSTAGTLAALIAAASTPSLVTATPPPDLIDALSAYAAAGITPTIPAGIEHAHRLVRRAEETAAPFAVAEEKIVILPPNHRPLKQLPDNLKRRTRMQKEARSVVDKIEDAVGLDDKNETTTTTTTTTGSTSGKTAAATVTSRTIDSHHYWYVDDSPDEQKWRRYSAAIVSRRGLGHFFDNLKDDIESDIGYLKSEFRGSHSHTSTVEITATPPVHPAPTGFKLMLSTMLVEKVRARAESSIAPIDSSAVTSPPAAAATSLNSVISSAVASASISQAADNLTWYDPTTWPSGIANEVKQETNSIKDKIDKLPMLAKIGLATLILVSSICLGFLIYCLCKLNMRRRRRSAAERVARKLQENPPSKPYYGGSATVPMSSTGFTSRPTTPNPGAADKKGKRRMSWSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7T8</accession>
    <name>A0A2S5B7T8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7T8"/>
    <dbReference type="OrthoDB" id="10679478at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="278" mass="29013" checksum="A0CCBEDEF847E9AB" modified="2018-07-18" version="1">MLVKRDRNNEPGSAEEEALLQQTEGIELTKQDVQEGYDTDLLDALPRGGDSSALTTSIPADSTTSSAFGSTSPAASSSLHLISSDTSHDPPVSDAVKLLPSEAAAALSPKRMPTKTVAPVIASPRNAAQVYAARARAAEFAGDVKRKDGTGPQAPRRLDDGAGGDDKDDAEIGTRWRNHSRRQFSLSQLERRVWIWLAIGVFACIAIGVGVGVGVGLGLKQGGSDDGEPGGKDRQAAPVRPTMMGGDAPMRVPPEVIVPVVPDVQPSAMSDDTSATPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7W8</accession>
    <name>A0A2S5B7W8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7W8"/>
    <dbReference type="OrthoDB" id="2529467at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="438"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="569" mass="60312" checksum="9A9DC0089DF66178" modified="2018-07-18" version="1">MTAPTPDTVAAFHTRLIESLLAQLRSIARVKSTAALSPLIDTLKDVDTWSSLQSLLRSKLGAPGTKLLRGDPDTLRQSGQAILFALERIGPQNLVEACLAIDGETVDSLAVATSPPSTRNDRSWQGLCELMAWLSAVRAPPAAPTSTSAPTATSPAETTAPVSPPVVKPEPVSASAGFAPPPRAGALAKEQDEKRARLSAATVANVANAPTSRPATSTSPPVAPTASVTSTAAPPGSKAAAFAMRTSAMSGSTIASTSAALPSGPPSAGFAPPPGPGASAFDKKPKAAPRKPRASAPPAAVVEAAQAQMDEAPRPKRERKSSVKVRESSAGDERDNDARVKASSNGKKRFTSYDDPSDSDGLADDAELDELASDYEEQLERKRRRLEGLQSDGSSSRRASGGGNRKPRDPAADRERQLAIIAKEEAELAKDPKRFKVGEAVIARFPNYSYWPAIVLDATTAPPKTQGKREKGSYLVKSIPTGGDHRWVPPDDSSILAVTTTQLDDIILGRYKSAPPQSWKKWRGELVDAAMMIKDEERLKEWFAHPTPTEVWQIAQAERKKAARASAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Y0</accession>
    <name>A0A2S5B7Y0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Y0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="193" mass="21063" checksum="BEBE10C584955454" modified="2018-07-18" version="1">MEAPSASSAPAEAATGGPLSHEPHLDPVRPKEWEQPRQRGDPAKRKPYEFLVSFLPNLPTRQQLQAEGLDCFVWAEDDPTASAMYKRVSPRKGRSTSQPREKGKGQAENDESDQAPEEPAPKKPRVQVDLAALPKPPKITMWAGEVARVKGWGSNGLQQRPVDVPGAMRSDRERAEKASGDEFAVAVSAEPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Z8</accession>
    <name>A0A2S5B7Z8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="12" type="ORF">BMF94_4046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Z8"/>
    <dbReference type="STRING" id="741276.A0A2S5B7Z8"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000032">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="230"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="412"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="542"/>
            <end position="543"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="548"/>
            <end position="552"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="623"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="624" mass="69216" checksum="CE23D47A530A07AB" modified="2018-07-18" version="1">MGDSASLISAPARSTEPLPLESRSLLVLHASVTGTAIDVAERIGRRARREGWAAQVKSVAQFNPMELLEHGLVVFVVPTTGNGQAPPQFIPLWTALLHPGLPPDFLEDLRYAVFALGDSSYGKYNWVGKKLSRRLDALGAHAVVERGEGDDQNEWGVESTFPDWLDALVQSIDPLFAAPSGFAPLPAAARPPPRVRLEKIASTSETSPPSGSIANGCHTASSNGALLWSDDARWARLVKNERVTSDGWYQDVREIEIEIEGVTPDERNRLYAAGDVLEIRPQNSAEDVERFLTTTRWSDIADAVYCVNATSSDQPLPPHIPPGYRTTLRHLLTYELDISSVPSFSFFEWLAHFCEGDMQERLREFASPAGYDDLLDYARRPRRTINEVLYEFRSAQIPPDYIFDLLPLIRPRGFSISSSPASHDGKVDLLVAIVQYKTILSVPRKGLTTSWLASLEPGARIPVRFDTSGQLRLPPSPAPLIMIGPGTGVAPFRALMEERIRTGAKDNLLFFGCRSVKADFYFQSFWEKLVDDGQLTLSVAPSRDQDDKIYVQHRIPDHAAQVWDYVQRGGSIYVCGSSTQMPKAVKKALLAVFRSEGSMTLDSEVEALWDQLEKEGRIVEETWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B833</accession>
    <name>A0A2S5B833_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_4042</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B833"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.260:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="412"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY72881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1385" mass="153269" checksum="4CCEC5C33BD76D0E" modified="2018-07-18" version="1">MLRTQLRLSPAACRAARLRPAVRIGARWQSTNTLETAAGTASDAGPPPFPRSTPAPSDRPRAHALYTVTPLPPMPPPLPADISSADTVLHSGGTSSLAPGVTIAHQAPAAAEQLAILGACLSSGDVARAEEVAKRIRTQWARAGNVGSLSTLLPPRVHTDFLKAYFVRAILPRSLRSPGATESLAKSFEGLNLPPSNATSTEASVDKSVAPLSTASRRSIHKAWTYFDSLFGSQWDAVDPLTQRTRRGHNGAIDASVIAVMLKGVTSLGFDVYNPTSLSDPDRIFRPITYLLPVLRQTGIDLLDVVRDPIFDIDLPSYLGKCSREQALDALEKTGKGREGWDEWQAVIDEVKREVERLREGREKEAKERKAVEELDPVVAPNTDVNVSLETLRTSLGTLSVPLSDSVMSRTNRQRLLEESSYDAARQLYIHEMEELAKVGKDRERGLQRGWLQSIMFDWHRKLSTALYDASCATGKSSPWGKEPDIEPFLRLLPTDKMALITIVELMRLCGGGGVSDGMKAARAVLTVGRAVESEYHAEALKEAYTNKELQDEISRISESGAIGPDGRLQNRSQEESLGILWRRELAKREQAGDTAWRPTWTQTIRAKVGSILVSTLMDIAHVERTARHPQTGETLTEMQPAFSHAYQYVRGQKLGIIKVNPVVAERLDQDPLSMTLHPRYLPMLVQPKPWLSWNSGAYLLHQTQMMRTKDSDEQLQYLQQASDNDTLDTIFTGLDALGSVSWQINRRVFDVVSTVWNAGEAIADIPNKDSLVDPVKAPLPENVETDPRARDTYRHRIRQALQARREAHSKRCDLNYKLEIARAFLDEKFYFPHNLDFRGRAYPIPPNLSHIGDDMCRGLLMFGEAKPLGERGLRWLKIHAANLCGYDKASFDERERWTMEHLEDIFDSADKPLDGQRWWLKADDPWQCLATCIELTNALRSEVPTDYACALPVHQDGTCNGLQHYAALGGDLKGAHQVNLDAGDRPADVYSGVASMVNEIIDRDAADGVAEAEILKGKVTRKVVKQTVMTTVYGVTFIGAKNQIQRQLKDRGDVPAEHLYACSLYLGRLVLDSIGDLFKGASGIQTWLNRCARLIAKSIPPQRIEAALQQQKPRKTTKRGVSPTLSRIPKEQMTSVIWTTPLGLPVVQPYRRPKKKQVSTALQTVFIVDPSIPAEVDARAQATAFPPNFIHSLDATHMMMTALACKDKISFASVHDSYWTHACDVDEMSTVLRDTFIELHSQDILGRLRQEFIERYAGHVVPVSKIPPGLRAAGMNPDAASPLAKPVENAEAVISELEAEDGPGSLSLFAQAGHVKRVGRSPTTDAWSVDGLDAEEGDMAKVWKGQTSTRTDSKLIYLADVLPPPPGKGDFDLEKIRDSSYFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B856</accession>
    <name>A0A2S5B856_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B856"/>
    <dbReference type="STRING" id="741276.A0A2S5B856"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="588"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="780"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="882"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1208" mass="127744" checksum="38BBC31F761E97E8" modified="2018-07-18" version="1">MQGYAKAEIEPQGANGRDAYQHAAADQHRSSVATRDGAAAGLSIADRRATARLPPPRMQQGGAIGQDHVKQERADAWAHAGAYYDDDRGRGRGGGEPYSQDPRAQTYPPHASPSFAPVAGPSRAPTGAMPPRQADFAPQSDPRARSRAIEYDQYSGGGSPMLPADAQAYHAAGQASAGPPLQRSAAGYRQPHEPLRRDQPYATEAANGARPTQPTVEGLLGHIARTEELRLVRARCKHINEARARGVYPPDDSRAGQPYPVEEQIHLDRQALQCSNREIVIIEACEAFFRAHGGQAHVVRCAEHYQAQQQKLRHQARMQEAARWQGQPDSALPSQQQSNNRPSPQQPLRIDTRAVDRAAAGPATSVPVPSGRQTHMSRPAPGFPHEQPEPQPRSAPPTQQTFPQSATGPRTSPANDRPAFRTANSFHQIQRAPSAPHPAQNLQHGHQNAQHQAFSFHQHQPRAVAVPPSPTRPSNANGKMPVSARTASNRHASNGYHDEPDMSAFGITGSAHTQSSPHQNGARAPPMQFSPEAAQRVPPVARSASQNSSRILQDDRGQQPLPGPTRRSPRHPTLILAEAGNLAELQAQISPQHFFGMLSHSLSRRGEGPPPERCFIGPHQVDLFRFSQLVIGRCAGYIQVDHDNAWSRIASILLPASVGDSDHDHLVAQLRDLYLHYISPYEDDWSSEMLRRQNPRPPAESSPSMAHLTPPSDSLPPPPPGSSGQKPRSRPASRLGGPVQFAPISTPATHASASTERVPGLPSFQGAPPASTPSDNASQRGSAAPSPTSPRSRASTVSSGSSMFASAFGAFGLGPNTAMTATTDPTSTSSAAKSSPEVAITPAADEPSLEDILAQVDAHQRQMSMHGASTTTTPLEPPVPLPTLLASPHASSSTAPSPASAAAAAAGQTAPFSQLTALDAVVETPALHRAASDSAISPHSDDAIVRTKRSREDASSRDRSGEEARRRKRDGADALSPRKVLGPVVGTTSRRRSAESTPDLVPSGSLRPSTTSSNGSAVSPLFMSNLPLPGSSPNETAGSRRKVQTPGGLTVASAVEPGSTTPSTLGATSDFDLLSLTTPITTDFPSDQLLPPPVEGANPWPGFDLFIADNGGDMGGDLQVDGGDGHQFDPAAFADLHAASFDTFKPMLSPQLGDSSSNGTFAPPPGSKDRAASAAALAASYPNAADFWHPSSLLDFEFAADSFQSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B889</accession>
    <name>A0A2S5B889_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3978</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B889"/>
    <dbReference type="STRING" id="741276.A0A2S5B889"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="9">
        <location>
            <begin position="493"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="585" mass="61564" checksum="77597D97B081A5EB" modified="2018-07-18" version="1">MQGLGIPSFGQASGTGVRKQRSQRFTVPSHQPGRTRSGDQPSGGDYDSNSTSSSTAAPPVPSLPYMPPPPPVQSLVSPPPPHLHQHHQLVHHYPPPDSYSSGPSPPVDPTSHLSLEFLASPTGMSPYPGPAFTSSQAQAQAPPSSGGPAPGNVSSPLSAGGGATADSGSDEIIETAIVIKSIPFACPKEHLLAVMASLSLPPPFAFNYHFAPEDPTSFRGLAFANYRSPSEAAVVRAAMDGLEIMGRKLRAEFKKQLRPGEKEMIERTKAIKRMRSAQMLATGGTSLGGGGDRERGGGGGGNGGGGWNNRREASDGARTFGQREFVPAAAAGVPPPVPAIPPYYQQHHPQQPPPPHHYLGSQQQQPPPHAPPLPCSYPFQRPPPPQYGYPNGNAGHHHHHHQHHGSISASSSQDPPSVAPTASSFGISGETSDLQQHHHGLGEGGGTTTSSEVSDVGTSVSQRVPTRRSSDGDESAAGSSQVGAGREELDMNDPTTLELYSRVLLFSSDSLRDELAFSRSLSTPQRRTVHLIAQKLGLDHRSVGTGERRCVVVYKRGCAPPLGAGVDADGRQRVPQTEPPRRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8B1</accession>
    <name>A0A2S5B8B1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PLP-dependent transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY73013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8B1"/>
    <dbReference type="STRING" id="741276.A0A2S5B8B1"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF165">
        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="60010" checksum="815D7670E23FBFAD" modified="2018-07-18" version="1">MTRCPGPSGEALSFNPQIFHKQLDRVHEHIKRRADELVEAETTSRPDLIERALREAPADLPEQGLGLNATTSHLLESIAPALMPGQAGPRFFGLITGGVTPAAQLADMLVSSYDPCVQVHWPEATASVALENLTLRYLLSLLSLPPSVFTQNTITTGATASNILGLCLGRDWTVARIKRLRHGEPNWSVPEDGFGGVEVDVFVADAHASVRKAAALAGIGRRNVIDLGDRAKEEAGYLGCFDLEKLEAKLRANEEEGRASIVAVSFGEVNTGALASDTPAVRALCDTYHAHLHIDAAFGAFAILDPSFAHYGPHLALADSITSDAHKWLNVPYDSGLFFSRKLSLEDTTEGATASLFDLTGPGGNAPAYLASAGPTANGPEAPVYPLVEQSKTLPSPLFMNIENSRRFRALPIYASLLSLGKEGYASLVQRNIAFARCAETYLRAHPAFDVLTPARPALPDTEAEDPWQFRTLNIVLFAPSDQAPERYRSDPDSFLRALNETRECFFTPTVWRGRKAVRMAVSNWMTGLGANDAEGGGREWEVVKGVFERVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8C1</accession>
    <name>A0A2S5B8C1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B8C1"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01075">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="516"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="738"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1324"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1333"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1363" mass="150593" checksum="0C2009A927E209A8" modified="2018-07-18" version="1">MSSGPTSVSGKLSKRSRLSGGGLIGRSRPAASSLPAQPLDPDHLGSTSSQPLFRPEGGSDDGFGSDEGEFEAVQAVDPDPFALARSSSAAPLSRISHLPPPPKKRAKTAAVPPSSSRGASTPIGGADDADRTGEGGDAGPSARGRGRGRGAKSASRGGAARGRGRGKSKTDREQLERLVEPTIEFPEHFLKLERTFKALNTVYTFCSTRKSMATTFEVLKGSVENLLKRPLELNDIAQIKSLLPEVITFAYISSDQLRVHASAAPDDEDPHAAAREKKRLELDEAYRAGAIGEAAKDLEKTDKGSNSTVLLFSFNDGELRSENGVGKVMRKKFQKKRKKGEEHSPSPLPPPETEPKFSTESMTTLINKRNTKFRAAVSDLLIACSSRNPPLDPVELLLEATEENLPVHPDELLTEEDMRERGVRERMEDLEFRQRNPDLRPSMLQIIDEITHDEDLYNDQIVENGHRTVPARQPIYGALDFEVSENLANALRQTKNIEADKLYSHQATAINALHPSAEHPLGRNVIISTSTSSGKSLIYQLPVVEALEHNPEATALYVFPTKALAQDQKRSLGELVAAVDGLEDVKVATFDGDTPREDRDYIRENANVIFTNPDMLHITILPQEERWRRFFRQLRFVVVDELHIYSGLFGCHVAFVMRRLRRICAAVGNRRVRFVSCSATISNPIEHMQTIFGVEDVLLIDEDGSPCGQKEYLVWNPPYIDEIDRKQGRISTIAETSRVFRFMMTRGIRCIVFCRVRAQCEILMKQVRQDLMLDGREDMANRVMSYRTLVKSKRPLVSVLTEIATQDRRKIEQEMFTGQLLGVIATTALELGIDIGSLDAVITVGFPYTLPGLRQQAGRAGRRNKDSLAMLICDPFPVDQHYARNPDLIFNSPFQQLNLDLDNPLVLESHIQCAAEEIPVHPVEDAKYFTKGDEDKLRQICMSRLVGDDDGFYHCHPRYKPSPARAVPIRNTEDEHYTIIDITGGRHEVIEEIETSRAIFTTYEGAVFMHMGRTFLVREVNHDRRIAKIEKASIEWRTQQRDFTDIDPVDALSIREVQGGATTASYGTIQLTSVVFGYFKIDKRNNILDTVDIHCPPFIRSSHGLWVEVPRTALEILLLKNFHPAGSIHAAEHALMSLTPVFAMCAEGDVRTECKNPEKELSSVTTTRKRPARLILYDTAGKSGGICAKVFDHINTLIAQAADTIANCGCQDGVASHLCSGANMIVSKLGALIVLDAILGRPIDVDSIPMQEPTKGVTPGGPGSTLDLAAAGVRPELIKAVQQRAMHGPQTRLDVLEEEDEMAEEALLERERVLAELMSGGSGLPMEAGFDNTRGDAPTEERETAADGEVFRLADTGGFIRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8F6</accession>
    <name>A0A2S5B8F6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="8">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8F6"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000005">
        <property type="entry name" value="DUF89-domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="10">
        <location>
            <begin position="46"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="484" mass="55355" checksum="66E1ACF6B8498C2E" modified="2018-07-18" version="1">MATDRSHPSAQPPAKYPRTPSRVDPNNPPWPAYRGYHEYSFAHATMGVRLPTILGKAIDDVVKTLNDEYDEEKIVDLTACIARMEDLMDDLQDNAKLRPIIDDGEGDIPLWNKMIARYFRGKDFMNAPWLFAEAYKYRRLHECFSLSKYWKTYDVFFRQKCDTFSRSSDAVFELSLRFAKPWQQDSSLSQEDALEAKRVMFHELTQICLWGNSTDLSLLINMTEEDIKKLQSTGGDHLAATEQNILGNHLSKVWEYISSSKFGSAGKGGRMDFVLDNAGFELYCDCVYADWLIQSGLCSEIRFHGKRFAWFVSDVTRQDFDWLLNSMIYGQLFPQVSDEELASLREMGARWKEYVKQGKWIYEDHAFWISGYTFWALKEEAPDLFLHLSESDLVVFKGDLNHRKLTFDCHVPPSTPFDVAIGNLATEAGAPPVLSLRTVKSDVVCGIPEGKAEQLDKDEPGWKISGKYAVVLLSEGRKGEPVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8J3</accession>
    <name>A0A2S5B8J3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8J3"/>
    <dbReference type="STRING" id="741276.A0A2S5B8J3"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="271"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="488" mass="51154" checksum="AE789C1F1DBF79EF" modified="2018-07-18" version="1">MGLAAKLAAAQAAGLSATPGYGGMKPQTASPYPPTQGHAAAAFPGQQPAYSSGGQGGYGQPQQSGEGGRLPDFGRPLEAKRKTDPNFGGKPGYGQPQQQQYGQPQYGQPQQQQQQQQQYGAPPPAVPGGRPGAVGPQGQMPYPGAPPAMGGPGYGQPQQYGAPGAQGGYGQQQPGSYGQPQQQQQPYGQQGYGQPQQPGAAAGGPGGNQQMITQILQQAVMDQKIQAFYPPGSLEPLAARIAQSGALPRIAAQWNIPMEIAMDLAKLALFDTVVLVDDSGSMAFEENGSRIDDAKLIVSRVATAATLFDTDGISVFFLNSRTVGNNITSEQQAQQLLSGIRFSGLTPLGTSLDQKILQPLLVGPARQDSLRKPLLVVAVTDGAPGGEARDTIVKAIKNAKNALSQTRYGADALSIQLAQIGNDMGARAFLEEIDSHPEVGGLVDTTSNYENEADDFMKTTGQELTPDLWLVKLMLGPIDSSYDLKDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8K2</accession>
    <name>A0A2S5B8K2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8K2"/>
    <dbReference type="STRING" id="741276.A0A2S5B8K2"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="9">
        <location>
            <begin position="94"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="10">
        <location>
            <begin position="276"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="321" mass="35264" checksum="DBA6A93598EF09A4" modified="2018-07-18" version="1">MLSARTAFSTARITRTLTRPNKLALAHQSGPTQLHVAAMSSSAAPAVPTARLAAVSNHETYLSQGIPSASSLDPNPLVQFSHWFTHAQSQPDSVPEPEAMTISTVRMPDGIPSTRVVLLKEVDDAGLVFYTNYASRKGRELFPDGDYESDAPRGAYISCAFYWRALHLSVRFVGRAHKVDRETTQKYFDSRPVGSRIGAWASEQSAVLESGERSQLELRVREYERQFGVPVGTATGSAVSVGPASSDGADKGQEESSSSDQHDKSREVEIPVPPFWGGVRIVPFEVEFWAGRESRLHDRYRYTRPEGAAAGTDWKVERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8P9</accession>
    <name>A0A2S5B8P9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8P9"/>
    <dbReference type="STRING" id="741276.A0A2S5B8P9"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="167"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="539" mass="56801" checksum="C09F395ED4AEE293" modified="2018-07-18" version="1">MLPYDGVPDEETSTSTAATTESASVLSRPSTSAWQWNAQYGLYFNADTKQWAKPLPDGSWEYADAVTSTTESALSSQAQSTTTTARRKWIDRDDPELEDEKYDPMAVPEEQIWPGGDDGDQEAGGADAQDPYANAPLLRLVVSDPRPDPSVLPRTHQVASIDPGEPVSIGRDKSYERRIRLKELAVSKSHATIFWTADPEIEETGGYWAIVDNASTHGTFIKGDGEKNYTRLSEAKVASTPTRLHHLDSIRAGSTTFAVHIHPSFACCHCSVSSDSSNLIPLLTTPSGGDKVDAVPIYQAKSKEQKEVERREQMAGLKAQFLKPNANGRKGGAQSGASVAKNVVKPADPRASQSDTGGAARAATPTFVDRAAARRHRDAGTSAAVPNALSRRGAPSPFFVVPGATAGSNAAVSSSSALPTPVKPANPFAADSKGAQLLSKLAGGGANSAQRGGSGDGLSGTGRLGTLIEARATLGGPGERRAGLGSRELVVGVENVAAAQSRGDVLLPGGRGTGTGANGEKRDWRDVGKERSYKRFREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B932</accession>
    <name>A0A2S5B932_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_3611</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B932"/>
    <dbReference type="STRING" id="741276.A0A2S5B932"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="82"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="303"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="538"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="717"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY73277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="837" mass="93865" checksum="B559B83B2634C9CB" modified="2018-07-18" version="1">MAAQTHSGRPDKGKGKAKAKPSGKGQKKELERKILDDLQLEVDHFDGAGAEEFSDLPLSKQTLAGLKSAYYTRMTDIQQRALPLALKGKDVLGAARTGSGKTLAFLIPVLEVLLRKRWGPQDGLGALVISPTRELAVQIFEVLRKIGGHHQFSAGLVIGGKNLKDEQDRLSRMNILVATPGRLLQHMDQTLGFECDNLQLLILDEADRILDMGFSSSLNAIIGHLPRSRQTLLFSATQTKSVKDLARLSLKEPEYVAVRENNPVINGKGKEKAADGAEEEEEALGEVPSNLEQHYMVVDLPNKLDMLWSFIKTHLFTKTIVFLSSTKQVRFVYENFRHMRPGVPLMHMHGKQKQMQRLEIYQRFLTSKHAVMFATDVAARGLDFPAIDWVVQVDAPEDVDTYIHRVGRTARYQAKGKALLFLLPSEEEGMLRRLEAKKIVVNKIKANEKKKQSIRTQLQSAAFQFPEIKFLAQRAFISYVRSIHLQKDKSVFKLDDLPLEEYAASLGLAGAPKIKFTSKQEASAAKNKERQVEELRQEIERKKGESSGSEAEDSDSAGETEDEEEDEAEEVAPVARKAPEVAEEKSKAAKTKYDRMFARKSQTVLSDHYSKVVDQDDDDNSALFGAAGDDQEDDFITLKRQDHDLNERELPASSFLSKRKLKQGMSKKAMMSTKGNPTKLTFDDEGGAHAVYELGDEDDFAALGDAADLRKEFVEKEGQELAKQDVLDKQRVREKRLEKKRKRKEIEREASGRGMAGEDNFEPMDDVVHPDFSGFDLGSDSGGNDDHEAERYERPARAPVKSQNRRARFEDDEDAEPQAKKPKVDLEALALQALGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B958</accession>
    <name>A0A2S5B958_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B958"/>
    <dbReference type="STRING" id="741276.A0A2S5B958"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="268" mass="29078" checksum="C04817320D5B9337" modified="2018-07-18" version="1">MSRPASRASTVRGPSALRQKSSESFLSSALARLSLTLGATAEQEDHARQSTLQGPDVEEATPAVFPVKKKKKLGKKQRAAKKRREEAQRAAAAAQSGPMRVNDNRIDSFQTLSLESLTTSAINWSDDVASAFGNGETASLLSHSELSSYASSVILDTLSSGSNTVPFGLRATSEKLAFYQSLILQFGLQTQSCLPKTIKKCTKLLRTIHIAVGEYLAVIKRGGNVKTEVPRYKSAAKLRQALSGKKNKKRVPRDLIKSQLLTVFMVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B983</accession>
    <name>A0A2S5B983_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_3675</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
            <location evidence="2 12">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B983"/>
    <dbReference type="STRING" id="741276.A0A2S5B983"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0243">Dynein</keyword>
    <keyword evidence="6 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY73340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="103" mass="11440" checksum="760972B81C6469D1" modified="2018-07-18" version="1">MAGSDTLENSSNAPQGPQPIIKSADMSDEMQKVAIEVAREAMKAENAEEKDIAAYIKKDFDKRYGPTWHAVVGKNYGSYCTHETGNFLYWYMGNIAILLFKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9E5</accession>
    <name>A0A2S5B9E5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_3716</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9E5"/>
    <dbReference type="STRING" id="741276.A0A2S5B9E5"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="15">
        <location>
            <begin position="12"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="54"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY73379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="195" mass="20042" checksum="DF8038752938259F" modified="2018-07-18" version="1">MAPYKPLPLSDSQHKTLISQALAARDGSYSPYSKFRVGACLLGDDGETFIKGANVECASYGGAICAERTAIVKGVSEGVRKFVGLAVSSDVNGMVSPCGICRQVLREFCPLEMPVLLVPASYVEGKTRSIAAAEAEHGSTEDTLVETTMGELLPLSFGPDDLAKPRPGAGGGSSAESASAGLPASETDRDATAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9I4</accession>
    <name>A0A2S5B9I4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9I4"/>
    <dbReference type="STRING" id="741276.A0A2S5B9I4"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="289"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="656"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="604"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="822"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="394"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="828"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="875" mass="92994" checksum="484D6F73958A77B9" modified="2018-07-18" version="1">MASEFNAQAGSVPMAVSSSSASLSQPPRIPRDPSLRRPSQDGNVLSISTEPAAVAPPPLSSSPPASAASSSSRLYFPTAPSRTSSAASSRPSVRSDSNDGRPVTSTSASVYPPARGASLVGGAAAPGEPIADRSLRTHGSNPNMSLFDAANMTPSMPSTLSMPTPIPIPASSTYSGDLGSAPAATAAYGALPMSNTDSAYSVEALSDRVGLGFSSPQPPTRTASTSSSSAAGATTVDLNAPPMLPPRESSVPPALPNRPSISSASLSALGGGSYSAAAAGTGPGDVVPTGFDEGALRALCEMDCGTPLLLDRMKQGMTSCREASTFLRKRAQIEEDYARALAKLAKSSAESYSAGDGKAGSYVSSWLTFLRTHEVVGENRLKFAAQLTEMSDELAVLNKEVDKNRKVAKELAAKLEKGLQEQEQLVDRARVRFDAAAEDLERLLVLKQGEMITPSSVPHAGSSSAPGATSKGRTFGKAMSKLKGPKNAAQYAKQEDEVRTRMGQTSDSYRAQVAGAQTARQEYFQSQLPRVLRSLKENVDELDLGTQYHLSRYSYLLENTLVNEGLTIAPVAPEDGPGLRTVIESIDLREDFKTYMQQYSLNWQMSGQQRGPRRDGPEEDGFPTMSPTTALGPPNPYSSSSLSAASPAAAYPTFGVDLGEQMTRDGVEVPRVLEKCAEAIELFGLESKGIYRLSGTTSRVQRLKAALDHDTEAVDLLSEDNLSDINDIAAVLKLWFRELPEPLLTWELYHAFIDAARIENDRLRHIRLHERINELPDPNYATLKFLMGHLDKIAQHDAVNQMSRSNLAIVFGPNLLGAPPPQLAHHFPGPASSSDGAANGSAPTTGGGGGGLQDMQWQCKCVETILLHFVEIFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9U1</accession>
    <name>A0A2S5B9U1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2529874at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1324" mass="134966" checksum="B321CD89475496E2" modified="2018-07-18" version="1">MKAGAFGRQRERGPVQPGGRVLPGMFAGAGTAAGSVGTATSSSPPPLRAGTRSPPAAKADAVLSRFGSGGGQGSGRFSNTSRLDRPVERVAEAAETTTTSRPVGDSISRARRLGLNRAARTPSPEPDPPQSPMSSDVEDEENEPAAHAFMRSPQRRHDGEDDGSRPATRAASSRPAEAATDPEPQGPPTEPSEEANRAPPRPLPGLLSSLWNRASELVGGAAPASTRENEAGEEDATERQREVDDHAQKDTSAGEEEEEGDEMPPTARTKNATRPILVPALVAPALTGTRASSATRTVSAPVVPAGPPPEPITYHRPPALHQRSMSPEIQRFRSQPSPYDWLDSRDESPIIPYMFLPTAAQADAMAARMRSKAAAAQATQPSQHWPAAAPHMQPYPPVMAAPHLSSSTNYPPTGTTTPHHLAISAAGGAATLIIGSQAPFAPQQPSAGLRVAGASAIGPEGATPIIPPLVQPASLPVALPAIRSQPPPSSVIAPVAAPAIALPAAADPAPGVAAFQNSVAVPTSFVPPTMPQGMSPTAPLGVSSEPLPRYSESELPSHVAPYVDEWAPATLPAGAPPDRATQTSSGPPALAPAPALVNLRAGNGDDSLPVHPSPAEITPPVPAPRPAPLGQAAYALAPMSLAQSGAPQAVGPAAIAPPLATTAAAVQPNPLPMTSAPPPLVAPAVLSYGSAPQIAPSLSATTAPVGGGVNSGLPDFGPLDVLKVAVRNAVLCDDVPKAAGHSASLPQQGSFSRAGPTGGIQAMGIQGEGDLPPMPRLRPIPVTPPPPAPPAQIAPPSLISPTSKSCLTAGCKPPTSRSATSFASRSEDASSRAGIHNGSTSTALGRITHTSSTSPSPDHTLGRVSSIEHARIGASEGSFAPTTSAVSQTTTAQVAQPGAYHTLPVDDWTSAAISPAVNSSNATSSVAAPAQLSPSPAPTSEIRRPTPAPVSPPSQSTLLPPPPVPARPASIPPLPRETSPDSRLAGLDAVDGSPARQSNEATVGQALALPDAEDAEDGRPDTTPIQPKLELETLDLDFGDFGTSFSLTTPTVVAAAGAHKALNGVMLAAETAPHRNDGRGNVLTSSEHHALDALDRAFDETASFVADFAHATLERARIDPNHTERTERWLEQTGVRAQPMSGLTFVLSSYRPMTAPPASVAPGLLQLTLSVEPAVPAVHRQSAPDSAAFSAPSSPNSAPALRMPIVNTCTYLPSASSGPSSPLETAISARSAEETTLARGRPVAPNSEARERDRLAAVVSSGQVNMAASPQVRAETDLAGAQARGATANSGSAGARLPPALDFEPLVGDKGETASEVAAMFGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA69</accession>
    <name>A0A2S5BA69_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA69"/>
    <dbReference type="STRING" id="741276.A0A2S5BA69"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="92"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="374" mass="41146" checksum="84E696EB73C084FF" modified="2018-07-18" version="1">MVWQPRTEEERAYYSVPKPAPSLLAQLLHTPVPAGDPTWGRASLPRAPDEARTRATHGHRDGKVRFGSTDGEWVAYQIWEPSHKANDRETDLVFCHGINDYGGKFAVHADKFLDEGYRVIVPDLPGHGRSTGIHVYNPEMEALADAVYAVIQDVALQDSKLVQEAGGSYTQTRKVFVAGQSLGGFTATLTCLKYGAPVDTSLPSASNASFRPTLSGGMFLCPMLAIAPDSRPSYLVELVARGLASIAGPLPFASANKGKNSEDPSVEEQFDQDPQTYSGKLRIATGLAVLSAVTDINTKLSHLRVPFLLCHGTGDRVTSHKGSERLLREAESEDKELKLYPDYQHILLRVGKDEKDDVRRQTVLNDMLDWLKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAI6</accession>
    <name>A0A2S5BAI6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAI6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16629" checksum="232B2AA0B11C324F" modified="2018-07-18" version="1">MEAKLAALDLSHAPRDESAPRHADADDERPDTSTCWFDRLPYELKYKIARICHDMHLEGRESALHWKKYGNFGPSTTVGALFQVSKEWSDIVAPIHFESLDIAQLISKRHSARQIRRYLCRRGSLVRHMRIHNIKPPKDVWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAU3</accession>
    <name>A0A2S5BAU3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAU3"/>
    <dbReference type="STRING" id="741276.A0A2S5BAU3"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015640146" description="L-type lectin-like domain-containing protein" evidence="8">
        <location>
            <begin position="29"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="64"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="373" mass="41229" checksum="BB7E7E12E0F31653" modified="2018-07-18" version="1">MRQAPSSRPTRFARAVLALLVVASSASSLFAVAKKSSPASSPPSGPKLDSNGEPISLRGNTEKTVPIRTHSLYAPYVDSDLQNRWFDFGGSTIINTNKHVRLTQDRPSQAGWLWSRLALAPNSFEVEFEFRVDGKSNNLFGDGMAMWFTKARAGMGPAFGNVDYWDGLGIFFDTYANSRHSYQFPRIYAIMNDGTKSYDVGKDGGDQEIGACSVNFRRTDVTAKARVTYFKGKFLELAIQHKKWDEWTTCFAVEGVEMPSQPFLGFSAVTGDVSDAHDIISITTSNIVYHPPSAGSVRRYALLPAPARVEVEEERLADPESCVQKPPKRRGIPGAGFFAKVFSLLKWVFLIAIVVVGVMAYRGRKATRSAKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB16</accession>
    <name>A0A2S5BB16_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 2-methylcitrate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.79" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000030">
        <property type="protein sequence ID" value="POY73969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB16"/>
    <dbReference type="STRING" id="741276.A0A2S5BB16"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="4">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="4">
        <location>
            <begin position="243"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="5">
        <location>
            <begin position="420"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="618" mass="67904" checksum="EAF5BB7297CCAD41" modified="2018-07-18" version="1">MFALASTSRTSLAQSTRRSAARSFASATRSGPSSSSLLTSSRASVARVALQQSPLNSSKMGQTRMSHGMGESTVPAPFPASPTPSRENPTSRSARSTPLYGPAAAAAGAQVRPDSDKVMQDIADYVHNYEIKSDVAYNTARLCLIDTIGCGLEGLRVSDECRALMEPIVPGTTVPNGTKVPGTPFQMDPVRGAFAIGTQIRWLDFNEFVSFFSASFRFSSLTLPSFPCSCSSLFILLRRGTGWLAAEWGHPSDNLGAILAVADYLSRSGEKLVVRDVLTAMIKAHEIQGCIALENSFNRVGLDHVILVKLASAAVVSEMLGLTRDQTVDVISQVFVDGQSLRTFRHAPNTGSRKSWSAGDACMRAVHLAYQVKRGQMGIPTVLTAKTWGFYDVLFKGNEFKFQRPYGSYIMENVLFKISFPAEFHAQTAAEAAHVLHKQLKDMGKSSDDIKHVQIRTQEAAIRIIDKSGPLHNFADRDHTIQYMVAVPLIFGRLTTEDYSDAVAADPRIDALREKMQCVEDKQFTADYHDPEKRFISNGLTVTLNDGTVLPEVHIDYPVGHKRRREEGTPLLEAKFERHVKPHFDGAHVEKILKLVSDQSSLEQMPVKDFTDLFVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBK2</accession>
    <name>A0A2S5BBK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Small monomeric GTPase</fullName>
            <ecNumber evidence="6">3.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBK2"/>
    <dbReference type="STRING" id="741276.A0A2S5BBK2"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="179" mass="20136" checksum="D5BA5B98F5DD0D69" modified="2018-07-18" version="1">MQTCLLISYTTNAFPGEYVPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSVVSPPSFENVRTKWYPEICHHAPNIPIILVGTKLDLREDPETINRLRERRMNPIAYQQAAGVAREIGAVRYLECSALTQKGLKNVFDEAIRAVLAPAPREKKKSKGCVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBL2</accession>
    <name>A0A2S5BBL2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBL2"/>
    <dbReference type="STRING" id="741276.A0A2S5BBL2"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015610634" description="GH18 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="21"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="886"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1260" mass="137624" checksum="8474163C1E5E7357" modified="2018-07-18" version="1">MYIAALLLAVLSATLAHATSPVLGQYWPAYNSELQSVAQIPFSYGSKNGLAYYFVTETDKNGFSLPEYQSTGNIGAFVRRAKQHGVRPLFSVGGWTGSVYFSDHVATSAGRTKLASQMHVFMLKYAFEGVDLDWEYPNGEGIGCNKRRPDDSANLLAFLKLLRAKIGAKKLITAAVSTAGFLGPDGDVLPDLKPYGKYLDYINLMTYDRFVVAYHRPEFASAQVQHGIPAYAISFTTKSSHLASVSIAGGKWDSKAYQDWTAVVPRGGPSDVNASSTDPCGNTSSGYSGQWLYKELISEGILSKDGQSGRGGYKRHFDGCSMTPFLFNPGKKHYISYEDSKSAALKAEWAVKEGLAGVFLFDTTGFDSNVYEAITGALCGAAERPSSRNRTSTRVQQPSHARPPHDLPDGPGSHLPTLAQSSSPLLRLLDQLPEHPSRRDFLDLRTVAKSSGALADVAFVRDFVLRANRHGFEDVGVRLFRQSLPLLLHPHSTPVAAVARMAESVLEDLVARKRWVAALDVSNALNVHDLTIPTLLVLRMRVLSGRGRFAEVVQTFRQNLERADPPPAAFDVAINAQLCQANLDGAQTLLAEKARRGLPTTAETYLLLLDGMDVFGGNSIMEDKMLGEGTEEDVRRGIVPRQDVRILNRLMSVRAARGALRDAIDVLHFYDFSPYPTDVVDALRALSSPAPVLSEVSGRRPRPDAATAVILVGIALRQQRPDLAERILVAAARSGITLNDHVAAAALRILLARHDIVAAEAFVQALEMGSASLGPVRFPAIPTSSKVCELLLAGMLRYKGVAGANASFRRLLEVEGIAAPVSEGMTLALVDYLAAAGPLSNLGLSSTVLLQVQQLTQGTTRPDSRHLDVLLKAAWQRDRLLHGGHARDQARSVMSEELSQGAPEAPRAASPPDEAELLVRPASARKQATPTSRLRDSLADRDVRHSRDTSRHVIRNDHILRFIDAKWDYLQTQVVDLGIRPTYHHVTVLMRAYLRMGDSRGANSVLRYATQDLGLEPHVAFYSTLIAGLARLGKFGAAARAYQDFQASGLEPDRNLYAAVAMSCARRRDVVAVERVFDEMRAFLRSRAPHPQLQAQALKTAASASASNGFPAVISAPYDPLLDALFVTILYRAQTGAGQYAKAQNTVSQSLDRGMVPDTVLLKALQRTRKWIRHKESQLGGSGRSTVRAGGVDNTELSRAELEQIKGRNAYNVSRVRKTVRRMTPSVDRGEIRDLERYWREVESGPDEAVSSELDHVEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBM3</accession>
    <name>A0A2S5BBM3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBM3"/>
    <dbReference type="STRING" id="741276.A0A2S5BBM3"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="94" mass="10713" checksum="4C2F2233021AA951" modified="2018-07-18" version="1">MSRFALSRKEEDSILSLCRTEALRACQTEVSNFSACSEGRTISVTWACREQFRAMQNCMSPHCFNSMSEAKLDEAKRRFFREGGLPKEATPPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBY1</accession>
    <name>A0A2S5BBY1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBY1"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="250" mass="27449" checksum="9224F4241DC1E6A1" modified="2018-07-18" version="1">MEHRSLVWPVHKQVCGPGKAFPFEMPPLKDDEFKALEFLLDLLEFPRPAGAADSAQPRAVSHVSLRHKCFSKEVPTLLLLHALGRSQYVPNINAVAGAVRAQMGHALTMMLALGQKTVPVFDDLCIAAAVLTCIEGKSETTAAATVTEKHIATSMHRALLTSNATRTLPMPGLKPFFLPPLSDADIADAWSALLSEALRPLTFSSHSDVDAWIASLTLTLRAFHRFATWHDYDDKSRRISSVRVIMLCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC19</accession>
    <name>A0A2S5BC19_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome assembly chaperone 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC19"/>
    <dbReference type="STRING" id="741276.A0A2S5BC19"/>
    <dbReference type="OrthoDB" id="2530228at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="34927" checksum="79A65D07F50B5304" modified="2018-07-18" version="1">MDFESTAHLAPAPSYALESSEGESDYEDEQSTSRVTASQRRRSPNPDATVTFTGASERLEKGGRVVFLVGEAGERMAQGVQVDNSPSGETSPSVSVLVVGQQAGLIQPSADSTTSLVFLSTALPLAALYPLAVRVLELLQPATVTVIASYHLPSYIPPAPVTSPIPPILYLAPPAPPPAIEKLAKAGAIQPFTPPNLLHGLAAALISVSSISAVSESTLLLLVPTTTTPPPLNGPFPPTSPISTSGGASMYDAGGPTGLGDPGALFRELAGGGATRRHPGVRAPTGTAPLQTIKDALEWTWWDPVANAGSGKGFEWLERQRKERRRSEMSSMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCB9</accession>
    <name>A0A2S5BCB9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCB9"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="656"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="761"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="71"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="561"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="940"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1145"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1234"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1337"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="942"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1234"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1250"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1267"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1290"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1337"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1388" mass="154929" checksum="4551B6BF06370716" modified="2018-07-18" version="1">MATVDGKNYTKTYSGLKSTAITAGAFILGGLLIKEVVQRIRRYPDEDRARKRGKGEGLPDRGPEAWALGYIFRARTYVCGIRSPDYPRWPLFWIWEAIKRDEEFYEVRSGADATTYIRFLRGTFRWMSFLLLFVFPIMLAINYVYAGSAYSFDSIDRTSLTALVNGTRGLNLLPIHVIGVWTVMLSWFVTLFWIARGVLRIRRNELRRLLSDDAERVRLGDLADDAPLREDFSPELDPRIPAADLGWRYRTVLVRNLPVELRTETALQTWFEEQFHARTDTPAETAVGGAKPAYPPPNGSVGDGSSGSDSAATSVAEPLPFIAEIVLVRRQIELNELWFSKYQAVLNDLETAHVRLARNVIDWVRVQVKKEEAAKAGAQQQSPFEWFKAHGPHRRRNKGDAAISEKATSGHDALLIEALRPYCTRPSSLAPVHETLWEALERLRRVDPTILDRFQPQYKLRHFRKASVPAIDYFLTKHNLLYSLIEDQRAREEEIETASTAFITFSRASDARRVREKLNWSRFNRLRRGKVFDLQAKLAPENRDLHWQRLILVSLSSDILRSALLNGAIWGLTIVWVIPISLLIGLFSLESLQRRLPGLATWLANHDVANSLFTGLLPTAIVLLLNMYSCTLIGIAKRKGLTLITESAWSASTQSAYWKFMVTNLLVIFCIGITAFSAALNAFNTPTTIFQVVAAAFPKGATFYVSYVLLQVGTQTGIEISLFGITWINHISIRKMVAPRKRASEGLPRFFGYQSYLPQHLFQIAIVLVFAILNPVVIAFGFLFFGFVLVVFKQQFAHVYYRRNFESGGRQVFRRLFRYSLDIAILAQVVYVAFFWTLKRFGDGGGCIPLLPITVFIKIVGTRWFDHLMDELDEAKIDLICGEKDPAVALSTPLEVEGERKKTTLASARTSFKNFLFITLPALVRHPAARLPRIGQQVRLATHWKKGRRARTGKSRNPMHRFRKHPMGDNDDRPMLQASQRPAGTGPDESPDLSRSPEVQQTVVLPAPTAGGDTSQEPTPAQAAAAARFLQEKATAGRNPAGEEALVTPHPPVLRDDRPVSHLRYRNPAQFTPLVRALWLPRDPLQAVDLADTIDLHTAFVSSAAGRGVLGTWDEIGSASSDEGLHDGKVRAAPEEVDVVIHSPSMEFRQDPLANKAPSLSPPTLRRRRSSQSAVNGEDVPAVSLPALPPPLLTVDPTLALGAGTALPATSVPLPPSPATPLGRPPSLILTHAERSRDGESDSIRNHPLASPARSSIRSSPGPEYVTASSPTSQNAGVSPTRVRTRASRSESIATVFSDTTSRYLRDRPHAPTIAEADEEGQPVSQNEAMRNELLEEERKSHLAHAQRDEARRRKERDEVGTRSGKGNGGLLRKLLLFRDENAIGDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCH0</accession>
    <name>A0A2S5BCH0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCH0"/>
    <dbReference type="STRING" id="741276.A0A2S5BCH0"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="249" mass="27820" checksum="F9735C9D90E611B1" modified="2018-07-18" version="1">MAYDPREAAVILAAENRARDHHEQYDPSHDFWHVDRVRRLSLSIAHHSTSSAPLHRIDLLVVELAALFHDLIDAKYLPKGSEATDAEGTLEPFWREHGAVVAEDRRRLVEQIVDNVSFSKEVKRIKAGGQTEWHLSCPELHCVQDADKLDAIGAFGIMRCAAYSAIANRPLFIPPTPPTTDASATASSEASPAGSSALDHFDDKLFKLEGMMKTERGKELARRRTETMRQFVDDAKREWQEAVGADVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD64</accession>
    <name>A0A2S5BD64_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD64"/>
    <dbReference type="STRING" id="741276.A0A2S5BD64"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="329" mass="36381" checksum="2488D8BD7490DAE5" modified="2018-07-18" version="1">MKPFSEPFGWAMNRLPPQLLMACITACCGSGMLLFGYDQGVLGGLLTGRPFQERFPSLTTNSNLRGATVAIYEIGCAAGALFGFFFGDKLGRRNSIILGMIVLSIGAILQFMSYELGQMIVGRIVTGLGNGLNNECSKAHHRGRAVVIEMATNIFGVMLAYWVDYGLRNNQTEAQWRLPLALQVAFALITLSMIIFLPESPRWLASRGRIAEARDVLHRLDNTPEEKARAISVDVQMNEILTAIEEESKTAVGFTTCFTMGEQRFFQRVLLGCGSQFMQQISGINLITYSPPLYLGTALSSVVLKNALSVKRCPYGFPILFFFDLRLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD95</accession>
    <name>A0A2S5BD95_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD95"/>
    <dbReference type="STRING" id="741276.A0A2S5BD95"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="289"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="971" mass="103862" checksum="F620253B5281862F" modified="2018-07-18" version="1">MASLAPDMAVDEESMPPEPTRVHHSGGRLGTAYGKITSPAKAERHYRTQKLRFLRMLGHATFRNGSHFAILWVSPTAQTAEVFGSEALQPKLDEWLGPRVQRQAMSCARQLNQRKAGHDLAAFGASVGRSEIFRQDGEVIDPYLDDADDQLEADETDGLNSERACAGTSARGHSAPSRLAAEPEAIQAADGPQLDQSSSVPLLTRDVSQVAAGSASPDRALAKTESLSSMPATPVLRAAAESEATRAASESTAPSPRPAEPSAAPPSSASAVTGGPVQSDLVDRQFTSAELEQWYSSRFDQLEYKVEKLVCRVWIKAIAPGKHKKFPYQDGDASKPEWWPADLRHKEPDHITKPERLQLLVHLIRRGPGTIVALEAATAANSALIPSEKSAILSSIYNVARQERKPNPTDPGSSPRTFCVSIPTETCGAFGADVGVRRKKRQAFAAATHSSDRSRRTRSRLEDTPPRALETSERERISAQTSEAMGDDDESPKAAEPACGDRTSSPSLGRNLPQAGTSAAPPSPPLAAAAASADRFKGAETEVSASGRPKRKLVAPARFAASTHSIGPQRARRPRLLDVGGASHRTEEGSARGSLLASLSSDSASADNAVFGETRLSAPDGTPLQSSAGLRSPPPTGEASRQRQPDREANQAKLARPSDAFSPETRDSSSGLHSPPPTGDSTRNRESWAAAGRFVRAPPPTSVPVAVASTVTNIIGDSLEPSPFRFSTAYTASDVCRGAFVAPTRNGLRWTESPDPSRQLDHPALVLGRDSTYGPPHSNEGTDRPPQAHFPSFDGFSHDIHAFPTSDIYTRPPDDRHSTPLRFIHDPVSRSRMQDVRDPYLMTPPGSGGDPYSMGPSRVPLVPTEDDWSAAFARQLDAAILAVGAADVFHSGNDLDDEELVSSEVMTSQTSVAETGSRTIRANLHSDDMHSGASTAFYAPQLSNFSPVRLHHGERNAPLASHSSDSLDAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDD1</accession>
    <name>A0A2S5BDD1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDD1"/>
    <dbReference type="STRING" id="741276.A0A2S5BDD1"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="79"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="870"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="981"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1090" mass="116266" checksum="A8A05334E2B19C34" modified="2018-07-18" version="1">MQRHEERVQRFESLLRPFAATPEGERPSADNLSASHIGELPPGHGRGPRSAEAWRREELRKLCGEGESTGWKAPARVPDDPKHLRATAYRFLLNLDEPEVAAKQYRAFLDDVNSHLNSLPAPFAAGSADAPLAKEDKLLKEIEQDTERTFGALAWFGTEQDCDSDALWTRLDAVCSTAGNEEQVPSKRTRRSRRQILLRPLFLYAYLNPGVSFVQGMSYVAAVFFYVFSQPRPQAEPPCISGDPQLEAEASTFFALSALLAQLRDLFLPALDGLAPSADGQIPPVALTTSGIGSAINRFKALLLVIDSTAADALDRKGVDLSGLVVRWLTTLFANEFPLPDVVRIWDRVLSLYPLASEQQTAEALSPVLGHLIDLALAIIELERSKIITPFAKAPKILATLQDLQIEGEGIDRLLSEAWDIRERRLGRAKRQSVVLSTPTKTGAGFGRMFGWSPSSAKALPSSASDFEVDDRSSVAGSETSKPAGHRFGSLAFSSPRSSQADLAENVTVVEGKVLPPPPARLDQHVTIASLIEEEMRATEAKVEEPEYGIEDDDDEEGLNEGPALHRRVASGWGGLKASFSRFAASDTAAELSKRATNLQIAAVQSATTASTRLQTSDAAAAISRAQTNAAIKAQLLKDQLAESAPEQLAKLKDAAAGATGRLVASTDADRTGVHQPGSPREAPFVPPSMLGDRDVPPLGPPRGESADMGRTPSGGPKPLLLSGSARRAQNSSEDFGSERGGSAQYVRSPSSSPTQTRSDKLLSPDVAVPPLSRSPSRGAGGHGRSTSHWDTPTRTSASAFHLRSSSTAHSTPTSVLDDQDSPIVSRRLQDTASAIRRGGSASRLLEDESLSPAVTRSAGERQRWQLTDAPAASALELPPLELGFDPSSFGQGFDAPPAAVVSRPMLDDGLEEEPPFFPPSGPSEVTLPTTRPARGSSLSDQNGTSHAFSATGSAVPPRMSSLGSTSASEEAFSPGGADGPIGDAPLAAQPSLSRSKVVRRSVASRKRDSRSSATSGSIDLTGPEARRVASDFLTRSTSNASGHRRRASELANRTASSTQSQERPEFDEGDFLEAYGDAEVLADEASEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDD9</accession>
    <name>A0A2S5BDD9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2057</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDD9"/>
    <dbReference type="STRING" id="741276.A0A2S5BDD9"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000114">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="340"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="169"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="275"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="346"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="475" mass="51895" checksum="C30AC73628BEA3F7" modified="2018-07-18" version="1">MASTQQITPIKVQKIACIGAGYVGGPTCSMIAYKCPHIQVTIVDVNQDRINAWNSDSLPIYEPGLEAIVKECRGRNLFFDTDIDKAIIEADLIFVSVNTPTKKSGVGAGYAADLFYVELCTRRIASVATSSKIVVEKSTVPCRTAQSMRTILEANSRPGLRFDILSNPEFLAEGTAINDLANPDRVLIGSLSTPEGRAAQLSLVDVYANWVDRQRCITTGLWSSELTKLAANALLAQRISSINALSAICEVTGADIDEVAHACGIDSRIGPKFLKSSVGFGGSCFQKDILNLVYLSESLNLPEVAEYWKQVITMNEYQKSRFAKNVVSSMFNTITHKKLAVLGFAFKKDTGDTRESPSATVCRFFRQENARISIYDPKVPEKQIFLDLTEPGVADDSVAVKEHVKVCTSAMEACTGAEGICVLTEWDEFKSLDWEAIYESMAKPAMVFDGRGILDADKLRSIGFKVFSIGKGVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BED0</accession>
    <name>A0A2S5BED0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BED0"/>
    <dbReference type="OrthoDB" id="428177at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015454279" evidence="2">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="528" mass="53556" checksum="7B4A91FCF39D9B70" modified="2018-07-18" version="1">MLSQSVALPLALAASLASTAVAFQSPILHNHGVRHHGKERARIARDFAGVHAALDRRLVKGGKGRMQRKVRRAEGAMMLATAANATESSSTPSTSSSYQSTAIWWLQDGWSGACGTDISADALQVALPLSVYPDASVKSSLCGTTVTVTAASTGKSIDCVVVGASERKDYTTFTQAAFTALEGDLQTGELAISFSLSGNAAPVVASSATAAPAPSVAAKVKVPETSEAPAKTTTTTSQAPAVTTTAAAAAANKEANLNLAQKQVKTTTTAAPAPAATTSAAATTDDGSDDDWVCDEEDDSSSSTSSAAPAATNRSAYTAQQASAQSDNSGDSSSSSEWTAPSSTASSSAPTPSSSASSASSSSSSSSASNSGVADTSGSLTLLSQAGVKGFLGDNSNAIISWYHTDSGTDSTSECGFPYSDSVPGFAPSVGTMLNNFGGDYEAAAKAYCGLEAIVTTPDGKTATLYIADGFDDTWVRTPASIDVIYDSFAQLYGSTTSNKNDVVQGATWKLTGNRNSKYAFKSTTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEF7</accession>
    <name>A0A2S5BEF7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEF7"/>
    <dbReference type="STRING" id="741276.A0A2S5BEF7"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="260"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="551" mass="58734" checksum="7DD886B0EB623C8A" modified="2018-07-18" version="1">MASLADELMNDLDDLGSGSELDDELDAAIGSTSGAAGPSHGGDNSANADGDEPVDEETDAAMAALPEGEAHVPAGGVKPAKELDEDAVKAMDLTGVAEVSKVAKLQGSRTMRDVLRKIDYYREHPDANLASDGESQEYQLIVQANNLSVEIDNEMLIVHKFIRDHYLPRFPELDSLVSAPLPYCRVILALGNGPELHGEIAGILPSGSVMAVKVTAATTKGHQLGEQEWNVVKAACDMMFKLDESKRTILEYVESRITLLAPNISAIVGTQTATKILGIAGGLSGLTRIPHSNIYLLGAVKRATTGFSTASHSVDRLHTGFIYQCPLVQRTRPEDRMKAQRKVGAKVALAARVDSAKSSPHGAFGEEMKGKLEAEMERLARPSAMKAVKALPRPDEKKKARRGGKRARKAKEAYAMTELRKQQNRLKFGEAEEEVGAYDDVQGMGMIGSTSGRVRANMGEARSKAKLSKSAKGRLSSIKAPSSGTATSGLATSLAFTPVQGLELVDPSKMRNKVEEANAKWFADGAFSTYQRKGEGIGKAMSGANGSASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEN2</accession>
    <name>A0A2S5BEN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEN2"/>
    <dbReference type="OrthoDB" id="2528456at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="721" mass="75708" checksum="2B939B083E2C7025" modified="2018-07-18" version="1">MAFFRTRKTAGTSKQVKTAGPSSSPPTAEANAQPRNSYGSANRLSLLFKKPFRPADSPPVLEPTPTSQQSATRPSLDAASTCVASDESLKTRTPPPACLPDVVGDAPSAIELGTAPRAGSTTRRAARPSIQIRPLPPLPGRESLGAIGLGLVNAPTSSDSNDTSSDEHRAGFSRMSDRRSSLPVGVEPASRNSAARADRPQSFCGVPPTARRRTSVQIAPKTSHAPEGTNAPTSSEAVAGRQRIAQFRAGWSSMSAASGEPKGRFATRSTSMIEFAATAKVKDVSHRRVSSGTLANPVTGGDSRRSSTASSLKPLALESAASHPSLKQLMKTKPIPPPPRPTRSSARYCLRPTRDFSTQTPAEWDEPSSSRSSMIGRPRNHRRGSSWGIPAQLAPGSLTPKSAVAPTLPPAPVQDSPVPSRYGLPSPSIYSVASFDTAARAGRASRGAGSLAFEDLTQIAEASSSPLPPKPVDMGSSGALAFDSPFVNYTMRLSPVTEAMRTPLVDSPAAPVPPSRSVTPAPALVDAVVCTKTDDLEATRSSLKVVVPTSADPLPRGSDSSTPQSPVSLSSSETSHATDSPATSTAESDCSASANLKKADSPFDLTTQVCLAVVALPITPTEQPFTRPSRLHAIPPAQLQARRFSEADKPVPRLRNVEAIGAEERAAKSRSFFLVQALMGDAPTNGLVRDWAKNVYSEDETSDEESLLGQPTSDESDLEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEX0</accession>
    <name>A0A2S5BEX0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEX0"/>
    <dbReference type="STRING" id="741276.A0A2S5BEX0"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000527">
        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="142" mass="15602" checksum="1D140C1458E618F5" modified="2018-07-18" version="1">MVAYDAEIKEAFALHDKRGNGTIANSSLGEVLRALGQNPTQKEVLDLQSQCPQDVDYDTFLGILNRPGGYDPAGTVDDFIRGFQVFDKEGQGYIGQGEFRYILTTLGEPLSDQEVDELLKQAEITPDGNLNYVAFVNQIAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF13</accession>
    <name>A0A2S5BF13_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BF13"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="741"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1230"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="844"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1281" mass="139134" checksum="81E2AEEC3DD3C57D" modified="2018-07-18" version="1">MAASNYAARHSIRTIATSTSSARRSRGKSSFQGQEQPGTVGKRRSSTSAKRLASLSPATPTPATIPAAAPPHARWDPLPPSGDDFMSDFWTDLQAKQRDSACAAGPPPPSVPRHAHTLLQEDAFLAMFASSSASAWETEQLAAADAATAAELAIPSEDLAELLVLASAPPPPVPSPRPSSYLDASRISRQSRDGVEYSPVHGPKEADADAADSALEAEQLAAESGVTESTAAPTTQSESVTEIFSTDKATSQVTPANAASRPRRPRSESAAAAAAATSRTLSRRFGLDILPPALVRPAESVRTDGGLPRLERVPVGEAADKIVPYRPSPLPTSTASSSRTTRVDSVPQPHHFPLASRTDWRLSSPARFKLHPKHPLPLWSDKETSTRAMGANRLVGIGPGAAKVARMGRDQEREGWGWKAKVPEGERGAWKDADRYVERYQRLLDLSKASDEQLYLASLARAGPPLERQQKGVTVSRATGTWLTDTSRVADAAAMSTEEREAARNKRDKAGGGSGGKTAVAEFRTQGGYEVTKEEGFKFESGMVLRISEAEPAAREDDGGPQSPPAAKLEAKWHVQGTLLEVRKDKLVVAFDELDMWPLAEDDAYQCALTCKGLRERVLTVARPSSDRIDIGLDLASYALQTEALAKLYYDPARQRERNAIETLAVQEGHVLDAGKAHVREWTLQGTELRQDLVPASEPDPEAQTGIESDLFRDNQLINSWIERYRRDDPLVLPGDPDLGLNASQTKAIAMALGDRLSLIQGPPGTGKSQTIVSLIALLKLHFRVPHPILLAAPTHVSVDHLVSLLVRAGLNPLRCGKAHRVSPEVRNWTIEKRQEEHPMWRPTEAARLASEDARQALQEFREEMRSLNQTSTPAVIKKDAELMETFRKTWRSFIMREQNLYSSLLATADVFCATAVGSGASKVLNMIDFPIVLLDEAAMCTEPVSLIPLMKGAQHATLIGDHKQLPAVVTSKEARTERLHTSLFERLLQSGTVESTLLDTQYRMRPAISSFPNDSFYQGALKDASIVTDRPAPLQSRYFSSRKSPTSHAPPSVSSAAPPRSRPESTVADAAAAFNSELFPVSFVAHTSPESSYRRSLLNRGESDLLIKIVGDLLASNPDLEASEIGIISPYYAQTRLVSNSFTSGFASARLGDLLHPDRAASAVDVEVNTVDGFQGREKRVILLSTVRSNSGGWIGFLNDKRRLNVALTRARDALIVVGNQETLRRAASRPLPPLLSRSRTDGDSVFADSDPDADPRIWADFLDWCQRHGVVKTAEQVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF19</accession>
    <name>A0A2S5BF19_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF19"/>
    <dbReference type="STRING" id="741276.A0A2S5BF19"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="315" mass="33400" checksum="90B65786CE72831E" modified="2018-07-18" version="1">MLSTTRVLLQAAATRPAPYRRAAAAASSTSPTSARAATPAPALSAAARAPTYASTPASQQALDPFGSSADEELSKVAPLAPPPSSASSSPRPRRTTPAAAAVDRSPLAEFGTPPFPASYADQLARAQLAEAEGPVASGSGIDWTTAWNGLGTAVISPEQAQLLMRPLTAEEIQIKPDGLLYLPEILYRRILNTTLGPGQWGLVPRGPETIQKGILTREWGLVVGGRLVSVARGEQQFFDPSGLPTAAEACKSNALMRCCKDLGIAGELWDPTFIRAFKKTQCVEAWVEHVGTGKKQKRWKKKGGQFEYPLKEVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF36</accession>
    <name>A0A2S5BF36_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF36"/>
    <dbReference type="STRING" id="741276.A0A2S5BF36"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="318" mass="34948" checksum="6AF750C2EDDFD169" modified="2018-07-18" version="1">MLESIYVCRHGFRLSWETQLWTPPTGIPRDPPLSKHGVDQAKELAQFLKRDLGIESPEHARSQGVAILSSPLYRCVQTATPVAEALGLPIMIEPGLAEWYLPVRKGLHPALASPSLLKRHFPLVDDSDAWTPLLVPPRVGESMRAIHLRAARLSKLLTAALAAKGIRKVILFTHAATQIALCRALAGDVQEGDPVLSQGAIEPGQEEQLGLWNDDERLSVAAATCSVSKFSAATTTTTTREAWQREWDGRTDFLERGEERRWDFTFVEEIAEDGIDDSTGKEISVTKSDAYKHLPTAAPHETAGHARAQSSQQVEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF62</accession>
    <name>A0A2S5BF62_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF62"/>
    <dbReference type="STRING" id="741276.A0A2S5BF62"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="284"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="718"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="767" mass="80727" checksum="235D531E26F33989" modified="2018-07-18" version="1">MAVDSTQYLQGASSSSTYHSPYARPPLQPTASSSVNNNNNNSSSSSLHLAGASSASSTSSVTTLNATSAASGSPLSPLSSPLVPVSSPTAAIDPSALFGIKPPSPADYDAYLRDAAGEQQQYHHHNDMSSAVMSGHHYGQQPFATGLPSVSQQQQQQFAPNGMTRTNSNSSGSGGGGGGQGPVTRMRSGASVLGNPSLGASAGFVSFDPDQDDSELLLEGDDYDDEEAAHVEGRPRKRKSVRDLRSAANSSAHASSGAAGGGASGSGSGGGAGGDAGGDKDDDKSRRKIQIEYIEEKSKRHITFSKRKAGIMKKAYELSTLTGTQVLLLVVSESGWVYTFTTDKFKPLVKEDENGQLSQGQRLIAACLEAKDGVPNLAAAACQNVNASSTGNFEANSSQHGGQISLKTGSRAARPTVTNRRLSSKTRSGAPTSINIANNPMDPSLPCPPNSGGGIPPLPQLPTPLSGGGYLGQDPMQSPLSPAGMQAQGRSLSHPPISPGRSGYSMQQQQQQAHHQQQQEYAELMQRTDMLQLQNPYDQSSAQHYDLYSNDIYTSDLHSLPPLPQPPAHISHHHSDSSLPSPVHQRDLQHQQQLHLREQHQQPQHHPTLSHSRSFSHSHRHRGEAHGQHRALHHQASHGHLPSASSSALYHNSSQQDSPFSHNVGDLSSNGNQGLYLEQGLPRNNGGGGGSSHYSHGRSSSMTGTPSAGGIDPGLMNPRTTNSTGWSTPSNPLQQQQDRSRQGSLQGTPIGMGPGGLAYGGEDVYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF76</accession>
    <name>A0A2S5BF76_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1498</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="741276.A0A2S5BF76"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="402"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="577"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="654"/>
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        </location>
    </feature>
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            <begin position="43"/>
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        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
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            <begin position="443"/>
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        </location>
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            <begin position="464"/>
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        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="750" mass="77779" checksum="36044D8B25A2A4C2" modified="2018-07-18" version="1">MPVTRHIRTHTGEKPHACTHPGDLNALDLHRCEKRFSRSDELTRHIRIHSSERGRKKTAQQQAAAAAAAAGGGATPPAVKKGKQSRQASPSEEKRADVARSGTDGSSSSAHRLEIQQQQQQQADSSSAQAAASQASNPYSAMLGYQQQPYYPPPPGYPGYPYPSMPMYPYGYPSVPPPTSTYPGMPSSNPATTSAYPGFPPNASSYTPYGYPPMMPQQVTSTSQQQGQPGQAGQAQQQQQQQQHMAGSGLPQPPASMQGAGQQHGQQQPIAGADGRPLNALALAAATGLHEMERERAEREQSRPGMDVPGAAGGSASGTGSQPGSASNTPYGSFDQNAAAAAGYWPYAAAAAAAAAQKYAGTGYATSQHVQNASAQVTADLVAQQQAQQQQQAAQVAMANAAAMANNGSRRPSHAHGVHSHHLLSPSDDSASRHSHSHDPSHPTHHGSLARHQHRHAYAPYSLPASTDHSLANSPASSPGHSEQEAQQQQQQAYTASQQHSGLDANGRPVSHGGSASPFPPVQGGPGLVPGIGMASQPGHGQQHAIGELQQQLAYQLTPGASPVLGPLKGLTLMSAAGSRAPSQAPSRATSPAPVQLPPLRLPGQSESDVQPSSAGGGGGRGGDRSQPGSANASRAGTPDATIEAQKHAFAAGNHHGTAQQHRASHRNHPYGRSQPGSPVNGQSQPGSNGARTAEGTPSAPNSRPTSPNQRTPAFASMTSMTSQAHAQLVADKMAAMKARQQQYEQQHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFD5</accession>
    <name>A0A2S5BFD5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
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            <begin position="130"/>
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    </feature>
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        <location>
            <begin position="281"/>
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            <begin position="19"/>
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            <begin position="159"/>
            <end position="171"/>
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            <begin position="172"/>
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        </location>
    </feature>
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            <begin position="199"/>
            <end position="208"/>
        </location>
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        <location>
            <begin position="221"/>
            <end position="240"/>
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    </feature>
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        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37057" checksum="659B8EDACB501CBD" modified="2018-07-18" version="1">MSGKFDSATYLRGLGWQGPGSSLNNSANGRAKPVSVVQKKSLAGIGRDRDTSFAWWDAVFSSVANKVGAAQQPEQRRTSTGILSHRPPPPKATAYEEDAAQAQASGSRLNLDAMAAVKLEQARRQLYSGFLRGSVMSGSRSDEEEGGGRDKKRPRRDDDDSDSDSDADSDQESCRESAVKPTKAERKAARVARKEAKAQRRAAKVARRAAKDKGKGLVASGTATPLSELSSAATSRSTSVDAGGDTSVDAGGDAAGVEQKLRDKALRKAAKLRAKEARLLAAASESVSLDTTPLATSAETTDADEDDEMAAARKAIRRAEKEERKLARALAKKARRTDAVVTVTATPITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFK0</accession>
    <name>A0A2S5BFK0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFK0"/>
    <dbReference type="OrthoDB" id="3596006at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="291" mass="32816" checksum="94263AF901397AFA" modified="2018-07-18" version="1">MPSTSEDRYQEPIPMPASRPGWPKIWGFDLGELNFSAFKSSNMFDRRWHLRRERFVAYQAAMLICLAAECTATYSLDKYEDLQTHVEDRFAPAHLYNNDIIDMEISTIVLCVAVACLFGADFFFLLQFPRRRYPLWYQRTKEFFAITITCGVFACALGSTIVIARNSAKIEHVSQAVADAAAAYYYRPPLQYRDWPVNIAYVCLLWPGWLACVVSTILMFKAADWDRLNGTEPRGLLHAAKEVARGAPLSARPSAAESSTEPLRPPYAIQSTSPSTSSATELSVPPEKPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFM5</accession>
    <name>A0A2S5BFM5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1464</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFM5"/>
    <dbReference type="STRING" id="741276.A0A2S5BFM5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000254">
        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="67"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="549" mass="59685" checksum="FB007EFF0770A526" modified="2018-07-18" version="1">MSGQLTPVEEKKTGFESTDLAYVEHASKGKDALDNPNLIEDARAATEAEHRLTLMQGLKRYPKAVMFSLIVSTCIIMTGFDCVLLGNFYGLPQFREKFGSRLPSGEYNISAKTQTAFSMAGKGGEILGLLANGYATERFGARITLITALASIIGFIFLQVFAQNVEMLIAASFLTGASWGVFETGTVTYAAELAPVALRSSLTAYVNLCWVIGQIIGSGTLRGVLGIESALAYKLPFALQWVWPVPIIIGILFAPESPWWQVRRGEVAKARHTVSRLFTGATPEEIDNTVAMMIHTNEFEKAVSAGTSYWDCFTGVDLRRTEIACVVWMIQNLCGSAFMGYSTFFLQQAGVPISASFDLSIGQYALGMCGTVSSWWLMSKIGRRTLYLGGLLVQTVLLVVIGGLGWVIPKHPEASYGVGALLLIYTAVYDATVGPVCYTLVSEIPATRLRAKTVVLSRIAYNIIGAVNGVIMPYFLNTDALNWGAKTGLFWSGACALCAVWTYFRCPEPKGRTYGELDVLFAQKVSARKFTSTAVDQFSGEHGVVAEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG02</accession>
    <name>A0A2S5BG02_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG02"/>
    <dbReference type="STRING" id="741276.A0A2S5BG02"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="230" mass="25089" checksum="6E192FEBEF616AC6" modified="2018-07-18" version="1">MTTTFKRAVAHVGSSDVQTDNQTKLRLYALYKIATVSQRPIEGSRPGMLDFTGRAKWDAWDRQGAEEGMDAAAAQAAYVELARDRFDFRIDNDDDDDSMQRGGGAKSGSTESVQRKRQPKKEQMVGVSMMADDFVDEAPLSRIHELALEGDATALEAFLARNSSSTTTDLNVRDSYGYTPLHLATDRGQTEAVKVLLGAGADRSLKDDDGNTALDLARLAEHSDIVALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG21</accession>
    <name>A0A2S5BG21_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG21"/>
    <dbReference type="OrthoDB" id="2590973at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26556" checksum="E5FA6890DC72016C" modified="2018-07-18" version="1">MYLRWSRTLFFLLTQALCIVEIGLASWALKYGIDKQHFAKSILPTAHLNLTDAFAVGGAVTAAAGVASLLCLCMLTWTIIFPRKSETLRSVRIKEAMFAFAIGFFIATLIPATYICARKSGQLSAPGLSPVVIQSLLKATGQNLAYSAQTPIKAYVIVGWIALLSLIISLVLVSIAARKTLKYGEDRTGPLQHSEHDLPTHHQHHTGSARDVSMSEPRTSVTTEKYNGVNGVTHAEKPIGSTVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG92</accession>
    <name>A0A2S5BG92_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acetyl-CoA C-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG92"/>
    <dbReference type="STRING" id="741276.A0A2S5BG92"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="302"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="44941" checksum="5EFE57748201AAC7" modified="2018-07-18" version="1">MTSLISSTLDSIRGTSGGKSKLLRKSPDDVVVTMACRTPLQRARKGGFKDMTVQELLIAFFKQAIPEMKIDPALIGDISVGTVLPPKAPYDARAAALAAGIPETVPLQIINRFCSSGLMAVSAVSNQIRNGEIEVGLAVGFESMSATPDRGADNFAEEVLAHPVARDTQHPMGWTSENVSKDFNITRERMDELAALSQQRAEVAQSSGRFDREILPIEALQLPAGATPTDASAPAPQRVKVTVTKDDGIRPGTTKEKLGKIRAAFPQWGNGATTGGNASQITDGVAGVLLMTRRKAEELGLEILGKHVATSVAGLAPRIMGIGPAFAIPKVLERCQITKEDVDLFEVNEAFASMYSYMIDIYGLPLDRTNVNGGAIALGHPLGCTGARQVATGLHEIRRRGGKVLVTSMCIGLGMGAAAVWVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGB8</accession>
    <name>A0A2S5BGB8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGB8"/>
    <dbReference type="STRING" id="741276.A0A2S5BGB8"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF40">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G09800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="158"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="415" mass="45236" checksum="0A4A23FBB56D6004" modified="2018-07-18" version="1">MLSKAPHGRDSGRPHRALIPDGASPQDQPPSAAYREFAAAQLARHESFSNSCFPARALALDDSLILHTLATLGSTRSTLIMAPVAIETPSQATAAAAAVAPHLLKANKPHAPEFKQSVAGLSENPLQRTYRGNKEGTIHLEGIPKISDPYEKREWVKQQLAAAFQYWGKLGYAEGLSGHITVRDPVMPDHSWRNKTRSGMRSSLTDLRPCLRMNPIAVHFSSITVSKLVLVTPEGYVHPDGAQLPINTAGFHIHTAIHDARPEIQAAAHCHSLHGKAWSVFGKPIDIMTQDACLFYDNCAVYKNFGGIVLAPEEGKNIAEALGPKSKACILQNHGLLTLGMTVGEAAYYFSALDRLCKVQLMTEAASASGIQRNIIDDDDASFTAATLQHPENVYANWKPEYELLVEEKGDKFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGW2</accession>
    <name>A0A2S5BGW2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGW2"/>
    <dbReference type="STRING" id="741276.A0A2S5BGW2"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="354" mass="37429" checksum="30EA25788DE9B635" modified="2018-07-18" version="1">MTSTQGLKVALHPLAILSISEHYTRTAIQSASQSTSSTPPQVVGALLGTQSGRELEVVNSFELVADPEAGLDHAYLVTRRDQFKQVFPTFDFLGWYSVGQQPSPRDTALHQQFLEYNESPIFLQLSPPSSQQLTAEEQSSKGDLPLAIYESVVELVAGEAKPTFVPVPYEVVTGEAERVAVEGVSKPEAGADGGAQGNLIVALSTQRNALQMLSDRVALIVQYLDAVSRGQARRDDETLRMIASLAGTLPSADAKTMPAMESASGGEVAMGSKEGESESGPKGELELEFMTEYNDVLLTTYLSALTKQLETANALLDKQLLVVSGQASGKEGGGPGGPGGEGGGGGRRRRAAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHP6</accession>
    <name>A0A2S5BHP6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHP6"/>
    <dbReference type="STRING" id="741276.A0A2S5BHP6"/>
    <dbReference type="OrthoDB" id="2530294at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015701527" evidence="2">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="155" mass="16417" checksum="D868F3ED185A47FB" modified="2018-07-18" version="1">MKTAFACLGALFALLSVVLAAPSQAALDARAEKVNEIRALRRQLNLATRKERRQPPAAPGAQGRGPAGQGPPGQDKAGPPGPPPSKLPPHLAVVNGHVKNLRTDPDHCGAPFFTSPESYNGVGKRFCDFGKCKLKCPPGLAQAIHQYFPDIMFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHS0</accession>
    <name>A0A2S5BHS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0488</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHS0"/>
    <dbReference type="STRING" id="741276.A0A2S5BHS0"/>
    <dbReference type="OrthoDB" id="1747031at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="167"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="301"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="412"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY76293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="512" mass="53100" checksum="F59AC8897E8F70CF" modified="2018-07-18" version="1">MSLTAAISEELPMPEPQRTAVDQKATETDKMLAASIGAVLTSLTMTPFDVIKTRLQTQPPRATPSFDSLHNSPWPPPIPSTSTATVPVECCKVASEKPAPGRPGPAKYFHPSAASSTSSASADLLCRFDPRVSRAALPAAGSHGVSANAAGRAAAAAGGHQYLHHLAPVTLSGSASSIACLYPASTGHATLSLPYHLSHTSGFAAPAPPSLAPNHAQHRYLTGFTDALAHIVRSEGATALWRGTAPALAMSVPGQVVYMVGYDSLRQAAFDSAPEWAQRARPDGGVTALDTNGRPPLKTSYVTAVPLLAGALSRTVVAVLLSPIELVRTQIQSQVPSTNAAAGSQAGLVSLLRDLRWSNAWRGLPPTLWRDVPFSGIYWAGYEAIKRSLTGGRGMGETSAPSLRTAPQSKANDFGIAFVSGAGSGMIAATLTNPFDVIKTRRQAAADAGAAGTNANRTFTILRNIVKQEGYAGLFAGLTPRLAKVGPACGLMIGCYEAISSFSAASRTTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHS2</accession>
    <name>A0A2S5BHS2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHS2"/>
    <dbReference type="STRING" id="741276.A0A2S5BHS2"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="68711" checksum="EB4673E69CD9D4A4" modified="2018-07-18" version="1">MTTRPCAILNLPPEILTLTLSLSTPEACSAFAQTCRAARAHCEASALWRLLHQARWDEPRPACSPHAESSTASHDDYTAAVKARTYAALSFRRQRDKRDRIEADELAAIASTLVDAADQRPAGTGDSLNQEWLADLLRASPEDLNGNEAILRLSPGRGPGVLPAAHHLRSSSIATPSVLEPLRSPEGEGGDATFVNARAAELVAHLHALSMPSPLALSSPSVRTRAKEIVYTRANWTRLSHYGPFRSDGSGRVDWRKVEALAIVAGANIRDASAMGWGEPPAAQGFGATTPVTWSTARGVPAQVPPEVATAVAPTGWTATRPLSAGPVRADSSNRDWSGLTSHELVGTYFFIHYPTYMAFQSQTRAPVILGDEDEAVGDCLPMVFELLPEGEWPPEIDQPDLSFEAQNEDEEDDEEDADYASDDTDAENSDHPSNSSEDNEFLPTEEDATVQAELRAFLQRVEQARRDLLHEGGATESPAQIGAYVPLDLGALLAPSLTGHDHPDLPSLRFRPRADQIQDPARPKLAFRGVPGRLAYASADGKIPAETVEMDKLYNPHGRSFRGTIEWIPEDQVAKVTFVVRYGSEDQWVLTGVQFGGPGSQSGIVGVWTSADHSPESPSGPFWYWPHVRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHT8</accession>
    <name>A0A2S5BHT8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">General transcription factor TFIIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHT8"/>
    <dbReference type="STRING" id="741276.A0A2S5BHT8"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="440" mass="47677" checksum="B495EB9DCA3C8225" modified="2018-07-18" version="1">MQAFALKVDPDAAAKAEEFRQDLNVRLVCPDCRDNSQLVEEFSSGDLVCGNCGLVLGDKVVDTRSECKRSLFPHLRAAGPHRQSPSRRAARHFVHALALVQQYSVLNKPFPLSPLFALDCHIPARLRPIRRRSFADSEGDDPSRVGGPADPLLDAADQLSTVISFKDGNTGVARSLQMAAQRVAKDSQGGTGRDLNNAYREIATMCEAISLPKSIIDTTKLLFKRVDEEKILRNKNETAIIAACIFIACKQGRVPRTFKEIVALTSVSKKDIANAFKQIDRLFDTSTPHGAASTDLDSLISRICNHLALSVPLQRACSYCGQKTVDDGVLAGRNPITIASSCILFVTTLWGSRVDPREISKVGGVQDSTIRTGYRLLLTVKDRIVDNRWFDDSRPADQRADWANLAGRSANPAAGANGAADGLPDDPSGDEVKAEGGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BID3</accession>
    <name>A0A2S5BID3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BID3"/>
    <dbReference type="STRING" id="741276.A0A2S5BID3"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="435"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="447"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="494" mass="51690" checksum="A16B4A1809E62EE3" modified="2018-07-18" version="1">MPAKIKTAAAAAQPPPTSTTKSTKYARPTKTVVAAAPLQPRKPTKTMIQYTSTDYEMQPAAAKHCFDESAADMSAYLDFTSYATPVLSADNDSFVVIPSTEQHHHQPASFANAFDGQAALRPVDDSLLDSPLDLELSPASTFATDSSFSSPFLVDFEGDFAGLSSSTSSSPLTSPLLATDLTSSPSLESVTYPSLFPSPAMTTSTTSLLPGGDIDMAALASSLGVPLPPVGPVPPMSAPLWSPSAVVAPLPFIQEEDEELLDVKPVVAVAAAAAPPVVTAAASAAAPTPKKRKTSAELKAEVESLVTEVPASTTAAASMTSAEEEEEEEQRKRDKFTGIRNTKKPPVAYDAPTLPKNYYTESATSKKRCGSTKVAASVSRAAKRARSASSSSSSGSSTPTPPEVAVVEVELPSAQPEPMPEDEFDESQLSAIELKRRQNTLAARRSRARKSAYIQELKDEIDALKQLNEQLRAQVDAGHGGARCTSCGGAGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIG0</accession>
    <name>A0A2S5BIG0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIG0"/>
    <dbReference type="STRING" id="741276.A0A2S5BIG0"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="325" mass="36139" checksum="7533D7974B19DADA" modified="2018-07-18" version="1">MSQQIPSVKLSNGAEFPLLGFGTWQSAPGEVGQAVSVALKAGYRHLDLAKVYCNQKEIAPAIAESGVDRKDIFITSKLWNSQHRPDLVEPALDDTLKELGLDYLDLYLIHWPVAFPAEGNPHDNLFPKENDVCKIDTSISIVDTWKAMIKLLDTGKTKAIGVSNFSPKMVDAIIEATGVTPVVNQIERHPRLLQKEIIQHHKEKNIVITAYSGFGNNSVGEPLLIENEVVKKIAESKGANPGQVLIAWGMHGGHAIIPKSVTPSRIESNFKVVSITDDEVKQINQIGEEKPARFNTPIEYKPQWSINVFDTEREQKEAKFQVKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIQ1</accession>
    <name>A0A2S5BIQ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIQ1"/>
    <dbReference type="STRING" id="741276.A0A2S5BIQ1"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22816" checksum="17DA6490A2D9272D" modified="2018-07-18" version="1">MATFSTAPVIIDGKGHLLGRLASIVAKQILNGQKVVVVRCELINASGSFFRNKLKYADYLHKRHLVNPTRAGPFHFRAPSRIFYKAIRGMVPHKTARGAAALERLKLFEGVPPPYDRKKKVVVPQALRVLRLKPGRKYCTIKRISHEFGWSYRDVVDRLEEKRKVKAAAFHERKVATQKAQVAALKAATNAAPITEKLASYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIV1</accession>
    <name>A0A2S5BIV1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIV1"/>
    <dbReference type="STRING" id="741276.A0A2S5BIV1"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="351" mass="38626" checksum="D23A315C5AA2E72D" modified="2018-07-18" version="1">MAAPAVATAPHLSVRRHPASLVPRCLHEPSLLELVRCPVSADMISYIAQRTVDVIPCGPIPYQEPMSPPTTPSRGEYEAPEVQASVAHPAVPPLEAFISILVQKSNVQVPTLLSTLVYLDRLRSRLPEVAHGMESTRHRVFLATLIVAAKNLNDSSPKNKHWTHYAGIFPLGEVNLMERQLLFLLDFDLTITEPELMHHFAPFLPRVTSKPRPRTRPPPSSSAIPLRDVACETVRIPARRKSNEQLATPPTSRRRISPRVDPLASQVSPTDSLSSVSTASPITPLDDVSPRALLPPIHVVAPVPYPLHDLHPARPLGRPASLIRSAFSKHLGRRTSAPAFTTFEDHEHSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJD0</accession>
    <name>A0A2S5BJD0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJD0"/>
    <dbReference type="OrthoDB" id="2558918at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20238" checksum="A1F1ACFC8F027D59" modified="2018-07-18" version="1">MAEDKLAEQEYALAHPPKKWVPGMRAFGYLALVASSFAVGTAAMGIASYFLQKYGNIFNVQRYPDMYTMHTINLALFNGIWTMIICLGAWALPLAFLAFLVFSATVMWAVIGGIFTVHVPFVKSGCSASSAKWARFVGQCKYYISLDALAWVCFALMLIWFVILVADIIVTKRKRHYLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B014</accession>
    <name>A0A2S5B014_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B014"/>
    <dbReference type="STRING" id="741276.A0A2S5B014"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="9"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="247" mass="27479" checksum="5234E23D87A684C3" modified="2018-07-18" version="1">MQDSMKPLSLTLIVAATPSNAIGRNSSLPWRLSQEMAYFARMTKGEDAHAKNAVIMGRKSWEGIPKKFRPLPGRINVVASFDLCVSSIVVWSLSLSAAHEAAVVHIFDSGDAPDTFLASSVPAAVERVRHSQQSPPRTFLIGGAQLYNAALKEATEPSLDKTPYSIDRVLLTRLFTEYPDCDTFLRDFANHQTAEGRPAWRRAGDAELREWAGWDVPTGRQTEQDKAAKGAEKIVEYEYQMWVRTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0M6</accession>
    <name>A0A2S5B0M6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000126">
        <property type="protein sequence ID" value="POY70305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0M6"/>
    <dbReference type="STRING" id="741276.A0A2S5B0M6"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015565300" description="Fungal lipase-type domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="104"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="404" mass="41876" checksum="72C1608BA39CECBF" modified="2018-07-18" version="1">MLSSSSVTAAAVALTAAAATLVSAQTDVSSSQFWHERYHGLLSMAAYNNDPTTVCAPTFDQAALQSSFPGSTEAPWQIINQFGPTASGASGFSVVVPEMDKIVVVFKGMFGWESTFNMSTANIGTLLNLGPNCANCTAHAGATQAYLEVREATNDFITEKEWVNTTGHQFSVTGHGFGGMLSLIMSIDQGWRGAVHWSHNHGAPRTFNPAAANLYNALFGGEAGQRTVANNDIVPTMIPESDDYTFTLQGFHIVGNGTSNSTYGYDYYVCNTENDPECLGGDSYEDHLGYYTPIGMCGKPYYGTNDTVELGYLSSASSAFYATATSTYTIPTPSTTSTTPSSSAMVTSRVASTGGAAGATTGAANAAAASGKAGSTSAALANVQGPLAAVGFASVFAVAMSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0P4</accession>
    <name>A0A2S5B0P4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0P4"/>
    <dbReference type="OrthoDB" id="2519809at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="93" mass="10014" checksum="A86B9B156CFDBC4E" modified="2018-07-18" version="1">MIPTQLRLASAAGPSGSLPPFDGRKGPHETVKRPTAWTTRKAGAKGIAPVYAWPLTLLTVGAGAVYLYSRSGKMENELHREARNPVFASPKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0W0</accession>
    <name>A0A2S5B0W0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000117">
        <property type="protein sequence ID" value="POY70422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0W0"/>
    <dbReference type="STRING" id="741276.A0A2S5B0W0"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="554" mass="61647" checksum="FDD0B4EA5F56F96A" modified="2018-07-18" version="1">MPALTAKPNFLIIVADDLGFSDLGCFGSADIPTPNLDALANEGCRLAAFHTASACSPTRSMLMSGTDNHLAGLGQMAETIGRNKVFQGRPGYEGMLNTRVAALGEVLRDAGYDTFMSGKWHLGMTEDSLPHARGFDRVFSLLPGGGNHYGYEPVLDDGSPVVKILPPIYVENGDFIDHRTLPKPFYSTTYFTERMLGYLETRDADKPFLAYLPYTAPHWPLQAPPEVVAKYKGRYDAGPEVLRDERLAGLKQRGIVEPNVTAHPLCSVGDSRPWAKMSDVERQESARRMEVYAAMIEIMDAEIGRVIAWLKENDQYDNTFIFFSSDNGAEGSYMEALPVLGDDFQANIRKYFDNSLDNIGRANSFTSIGASWAQAATAPNRMYKAWITEGGIRCPAIIRYPGFRNGSVSQAFTTVMDIMPSLLEMAGVSHPAPSYRDRKVLPMRGKSWVDYLSGRTDYVHSENAVHGWELFGQSAIRQGPWKAVWIPSDDAKWSLYNLSSDAGETQDLAEQEPERLVEMIRLWRDYEAETGIVRLDPDQAFALRGYGFYRGTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B149</accession>
    <name>A0A2S5B149_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B149"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="230" mass="25508" checksum="BD66F5D3F3B0E145" modified="2018-07-18" version="1">MAELQELIATQLSALSLRNDDETVEFIVGLVEEESFEPEDRRSAILGMLEADEDDDTTTSSVDKLLEEASAHQEKVLAERRAEEEAAAAAAAAAAGGKYTKPEGKKLSPADEAKRKADLLKQYGYLEEETEADRIAREESERAPEKALKDPSQMSKKQRKKAFEGVDLLALPNMNKAHVDAADKQRRAASASAAQAKKARDEADRKKQKDDEKRKLEEKRKKAAKVERKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B162</accession>
    <name>A0A2S5B162_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6682</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B162"/>
    <dbReference type="STRING" id="741276.A0A2S5B162"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="113"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="447" mass="48195" checksum="90C608BD645D4142" modified="2018-07-18" version="1">MAKSKAAPISAAPSSNWKSLRAALNPAVAAAATIKDSNKRKRRHSSVTSVDSTATGASGRSVKAKGKERAVEPNDEDAAPREKGKRVRANKQLVPVDEIMKGGSAPWQQETGQYLAMDCEMVGVGPEGIESTLARVSIVNYHGCTILDRFVRPREKVTDYRTWVSGVREEDLRNAPTFAEVQKEVASLLDDRILVGHALSNDTTVLLLSHPRHMTRDTSKYKPLQGLARTKRPGLKTLAKLVLGVDIQSGEHSSIIDARATMAIYRSQKPAWEDALLKHSTPSLLTTTTPALQTLDLTNVSLTGVGKKKTQSLGLAATLRHVRNDRMLESGSHGGIFDGSDDEDDEEDGEEDETAELVENEKRKKRRVEEGDDLVLGFDFDKRPKVIEPAPAPVVNGGAAAKKNKKKPSAAAKVRGRSGGSAGGSLGGAASAGEKRPAAKEGWWEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1G3</accession>
    <name>A0A2S5B1G3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannan endo-1,6-alpha-mannosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1G3"/>
    <dbReference type="STRING" id="741276.A0A2S5B1G3"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015684333" description="Mannan endo-1,6-alpha-mannosidase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="62408" checksum="8B6E787EECFE0E94" modified="2018-07-18" version="1">MRLSPPWNAPLCCAFAALIAVIAPRPTFALDSPAGSPVERGDTSPNPEGYEPYLSFPHGTRTGHAFLPFQPDDPIHPLLANLSLPENPTNPAYPPPQWANNRHPLYTPGKPVPEFKTEEFQFDPVRLDKRKVVSSVPVDFPPSAWIDINDLSTIATLAQAAVARMQTWYEGGVFEWTGWWQTPVLGMAYTSLDLALGNKVNERLIKDLLISNDGLGWMIDKYIDDQSWWAMFALRAHQAYPNSTWLDMVETINNNNTLYWDTTCGGGVLWLTYRPLIKNTITNGLYFSILTRLYRYTGNETHLDYAMNTLNWWLSWGFDADTGQVYDTVTAQWEGQYPSSECQRTGLETWTYNSGAFLFGLADLYYATGNTRVLDLARTIAYAAIRDFVPDATTGILVESCEDDPPPSAGKPPGCQQDETVFKGILMLGMAELYVARPDPNIYNFINTQLLSNAFNNVDDSWLFGMWWGGPWNETTAGPKTQINALCLIAAAATVNADYLSSAGVNIAVKSATDQIAVPAATATGAAGNTDRNQEIVQQNTNAAVSARASVLALAGLLTGAVALVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Y9</accession>
    <name>A0A2S5B1Y9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="2">cDHQase</shortName>
            <ecNumber evidence="2">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000098">
        <property type="protein sequence ID" value="POY70701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Y9"/>
    <dbReference type="STRING" id="741276.A0A2S5B1Y9"/>
    <dbReference type="OrthoDB" id="8191625at2759"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF3">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="182" mass="19794" checksum="4ABCA8CEB235BE15" modified="2018-07-18" version="1">MPTEFSTTSTGVRRITKVDPAEALEKANDPKTFLLLSGVNHALFGKRDAKQYGTTTLAEIEEMVTKVGKELGVEIVCAQTDYEGEMCQLVHYSRCLGGVVMNPGAWAHYSYALRDAVDACDSPVVEVHISNVYAREEFRHKSVTAPIVAGYIAGCGILGYELGLRTAIQRRAERDALKPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2X5</accession>
    <name>A0A2S5B2X5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_5891</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2X5"/>
    <dbReference type="OrthoDB" id="5566853at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY71134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="100" mass="10990" checksum="DF317F163F09452F" modified="2018-07-18" version="1">MNSAAFERERDRLVAEIAENLGKCVTAVNQLNRNIENVTSVDDGFSSVYDTWSRFQQALANGSYADAEQPAPPQLLARENDETIRLPPGIAPGRGETLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B301</accession>
    <name>A0A2S5B301_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GPI ethanolamine phosphate transferase 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B301"/>
    <dbReference type="STRING" id="741276.A0A2S5B301"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="164" mass="17621" checksum="57806110BA5FF957" modified="2018-07-18" version="1" fragment="single">VSILALLAHVSFFATGHQAVISSIQWSTAFIGFPSLTYPFSPVLVLLNSLASFILTAAAIPLFVFWNLSPTLRDQGAPMAVGRNLLRAGAAYTAYFAALAFASAVCAAWLRRHLMVWKIFAPRFMLAGLALLATDLVVVVFAMGWAARGTLAKARTTLGTRFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B313</accession>
    <name>A0A2S5B313_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B313"/>
    <dbReference type="STRING" id="741276.A0A2S5B313"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.17, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="595"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="808" mass="86709" checksum="373A83B4F95CC1B9" modified="2018-07-18" version="1">MTVKKAITVLIGLITLILVGTVIVLSTVVQYFGVDKRDVIQDYEMALVERLANAARQLPTDGTPAQAHLSHSGVGSTYAEDTPLARAGTAQAVSSGDVKVTAGDEIGDGNSVNEFLDRLQERGWIADSPPSTEDLAKVAAKAGDNSPQQRIPKIIHATWKTHVLPERWEKVRQGCIDLHPDYEFKLWSDADSRAFIAEHYPWFLPTFDGYTYPIQRADVIRYFVLHHFGGIYMDLDIGCRRNLDPLLYFRVILPQTIPVGVSNDLMFAEKGHPFMDLVIHNLITFDHTYGTNYPTVMFSTGPMFLSAVYGMWPKDTPDGVERHVRILPRRWYGKNAPVTEMEDSYFDHFYGSSWHADDAGFITFLGKFGIALMYAGVAVVVLGGIRIFWTKRPGFKSTPRQIGPIALPYEALPFARSGGSSSSRPGSPSGSRSATPAPRADGKVGGGGLFYMPVWLYPGDRTPGGRSPGDSQGAWTQYFSNLSFVDDGNGGHRYEPLPNFSRPPSPSNNSILHAPGSSHDGAFDGVHLHSIRPTSKPTDAPPSSYSEPPFTSPTSPNPPAYSALRSWGTSLFRGFPFPSPSSGPEPLLPVAHAAGTATSSGADRTGATTPTPRRRASADLVVDRDDGRNVPALSKQHEAARFHLSLPRARSPSPAPPRYSPHVAAGVGEQQRPGSPDDEGETVVDARSRPARTGSDGVVGRPSPGNVGAPPPTAAEAARHGSVERAASHAGGQDDVARGRRAQPPSPAAGGVGAHDLEDEVDAVLAADDDALTARAAGHEAVEAQVDRLLSEMAPDAVASSPSSPRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B321</accession>
    <name>A0A2S5B321_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B321"/>
    <dbReference type="STRING" id="741276.A0A2S5B321"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000138">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="339"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="599"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="704"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="76434" checksum="41C958FC79BD447F" modified="2018-07-18" version="1" fragment="single">THANASSDENSDSPSGSQAEARGDAQTFPREVEPVQPAEVGTARHSLFHPAGGGSSSSNTPASANKGGDGPDSVAAMRKNPRQLVAHLDEYVVGQTRAKRVLAVAVYNHYARVPLAPSATSTAGEPPTEASRSSSRPSSSKQDKAAPPTPPPGFPASFTAGWTQVEPTADERKFVDMHLARLATLPEWSSTPSGGLIGRPSLQRHAADLKPTGKRRWEAKKADEGDEAGSTAASGKTAAADKSDEKNVKDGASQEAELEERFYRTPSGKLALVKTRASDPSASPEISIFDTSESSTLTASAADERTDVSAILSDFLGQRVGEPIASASLAASKVEPLYEKSNILLLGPTGTGKSLLARTLARELEVPYVSVDAASWTAAGYVGGDVEECVARLAEAADGDLEKAGRGIVFIDEIDKIAATSGTTRDIGGTGVQQALLKMLEGTTVNISEHGYSGGGGGGPASMFGGFGRRGPSREPAMVDTTGILFICAGALQVLSYSVGLDKIVQSRISKGSIGFTSKIAPAPATAAVTVQSVPTTPLPASPTAASASSSIVAPVTGHGLQPDLSPLLEQVEPQDLVQFGLIPEFIGRIPITAALKALSESDLIRILREPKFCLVQQYTDLFAASGVQLSYAIAAQAVKKQTGARGLRRIMEHVLLDSMFDAPQSSIRYVLINKAVVTSGEPAKYYSRSQKHLFEIDHTAEEDTVLSPSADSVTPPEQAQTKPKKRSAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B326</accession>
    <name>A0A2S5B326_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Phenylalanine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.24" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B326"/>
    <dbReference type="SMR" id="A0A2S5B326"/>
    <dbReference type="STRING" id="741276.A0A2S5B326"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045548">
        <property type="term" value="F:phenylalanine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="704" mass="75631" checksum="799288CCFA0D02A7" modified="2018-07-18" version="1">MAPSVDSIATSVVNTVSNGIKKFSATSASGSLLPTTETTQVDLVERILADAGATDQIKLDGYTLTLGDIVGAARRGRTVNVADRPDIREKIDASVEFLRTQLDNSVYGVTTGFGGSADTRTEDATSLQKALIEHQLCGVLPTSFDAFSLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRIVVLEALTNFLNHGITPIVPLRGTISASGDLSPLSYIAASITGHPDSKVHVDGKIMSAQEAIALKGLQPVILGPKEGLGLVNGTAVSASMATLALTDAHVLSLLAQSLTALTVEAMVGHAGSFHPFLHDVTRPHPTQIEVARNIRTLLEGSKYAVHHETEVKVKDDEGILRQDRYPLRCSPQWLGPLVSDMIHAHSVLALEAGQSTTDNPLIDLDNKMTHHGGAFMASSVGNTTEKTRLAVALMGKVCFTQLTEMLNAGMNRALPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVSTHVQPAEMGNQAINSLALISARRTAEANDVLSLLLATHLYCVLQAVDLRAMEFEHTKEFEPMVVDLLKQHFGALATVSLEDKVRKSIYKRLQQNNSYDLEQRWHDTFSVATGAVVEALVGQEVSLSSLNAWKTACAEKAIALTRQVRDSFWSTPSSASPALQYLSPRTRILYSFIREEVGVKARRGDVYLGKQEVTIGTNVSRIYEAIKSGRIAPVLVKMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B371</accession>
    <name>A0A2S5B371_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B371"/>
    <dbReference type="STRING" id="741276.A0A2S5B371"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="260" mass="28287" checksum="DE7AC37C0C7F41C0" modified="2018-07-18" version="1">MASAQLISKRRNAELSEFFSRTLSSEGYSGCEVRVTHARTEIIIRATHTQEVLGEKGRRIRELTSLVQKRFRFPEGSVELYAEKVQNRGLDAVAQCESLRYKLLGGLAVRRACYGVLRFVMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPVKDFVDTATRHVLMRQGVLGIKVKIMRPWDPEGRMGPSKPLPDVVTISEPKPDVEYASQVQSVNVGAANIPAPAQAAQDAAVSAGQEEPAQEVAVGAQEGAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3A4</accession>
    <name>A0A2S5B3A4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3A4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="57731" checksum="3D48AE5124652BAB" modified="2018-07-18" version="1">MTAEALAQTRTDDSTALADGLERLHVASAAAPPCARVAASSAGATEASATFALPVELVIRVLELAVAADRSAERAILLIAPANVSKAWRYAARVAFWRHVTLEGVRPSKWDQRFADSILCEPGLLRTTQTIHFGSGLRSSSGVDQTSADAEALAHFRDEPVADAIACEDRDSAFRQLLCAWSYLIASVYERRMMFRTLGEPDPGAATRNYTLKAIEVDLASMHSSNLVQFLQGLQAFASLRTLTVNLHPTRYYWADEDAPLSSIPDPGLAVSRLNLVMLPNAIIDSLPRFINLCSLILPSERTEAYTELLRSLITALPNLRALRQLLLIPQARRLSPDDGHTAGVDYRTFLAALPLSLTHCSVRDVVFDSPSDRQALQETFGLQTGHAVVRLFARDESISRLLLRIFTRAPRSVEWRELRHRAFPSKGCAPKHERIPKPRRTQALGIEALTKTPAASIPSAPLSFAQATQAKSEANAADEEVLAGGSESVIDGVTSAVDDAPGEPTPSTPQAPVTPRAAAAPTPARRECCILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3G2</accession>
    <name>A0A2S5B3G2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_5635</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3G2"/>
    <dbReference type="STRING" id="741276.A0A2S5B3G2"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="FTP" evidence="15">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="857"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="864"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY71323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="915" mass="99820" checksum="698F844516B12B86" modified="2018-07-18" version="1">MTYYTRTYPARHPRPRTYLATAAIAVAASASLANSLVVPASIQQAPSYGPLGTVDTLTSSVRKTLNWGPNVPNVVEHAHDDDASGILSLFNADHFDAIHHIGQRCDHVDVSEHTALGRCVGQELARAFVRKLHPHNEFNLVSATLSSHSGIVHAHFVQVVDGIPVANGNLNVNVDLHSAKVLSYGDSSFTHRSVRSRDRKSADKRARVGANWKNRVQRWTKEAVQAVESAAGQVVFGGSSGGAADSGPQGTHAGRDQIADPREGLLTFLAIQATNVQLLQRIESAPRATLVDQMRIVPVARIAKFDGTPSADSHDYIIENVPELVDEPVKATLTYVHDGSELKLTWKYEVKTHDNMYEAYMTADSGITPGDEEAVLVIDWVRDYRATGGELGIEAMATFGGPRSLLRDLDARPPLASANAMSTSSPRASTTDEKLVAKMREVEPTYKVYSWGTNAPDEDKRHVLHGAPGLKLDTEASPAGWHTVPKDHRRAAGPFNQDTFYFETRGNNVLAQDNPDGGNSMDGFRANGGDKMDFEFPIHMTKPGKPLDPVSYINASVTELFYTNNLYHDLLHRYGFDEESGNFQENNFDRGGRGGDAVQANAQDGSGYNNANFATPPDGSRPRMRMYVWNAQQPYRDGDFEAGIVIHEYSHGLSTRLTGGPANSGCLGWGESGGEGEGYGDFLATMIRVHDVNVTDYSMGEWASGRKNGIRYFPYSRNMTENPSTYKYLDKPGYWGVHAIGEVWAEFLFEMAENLIDVHGFNPSLFPPAPNAKDDSGFYSAAALEKTGKRVPAHGNTLALQLVIDSMKLQPCRPSFINSRDAIITADKALTGGDNECTIWKSFAHRGLGPNARVVGSTPWGGGMHEEDFTVPPKCRDSKKEPEHGKPKPGKPGRGKERQFGGRRAAAGRKGRAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3X6</accession>
    <name>A0A2S5B3X6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3X6"/>
    <dbReference type="OrthoDB" id="2537919at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="92532" checksum="CA9CED367AA36F89" modified="2018-07-18" version="1">MVSDDVRGRGCVLVEFVIVDHSEHFPLDEQYHHAARVLLQHLIHAEPLSPDDLPAGGHLFGISCFFRLLLLDVFLPFGLEPRADHRIASHGNSSFKIVYLVPAFVIVPLVAVFAILACTYGKCWAKGRQKTPLPGSNGESSAWWGGAVGSWRRGMHDPDDADEELGGLVGDKSRGLGGSAYEYDEKRFSLPSNRGGSKWTNVFSIASRSAIPYQSPAPDAAIPFLSVTGAPMDAPFVPPARSSSAHDFTRWVTRDPQPVGASSAQNNGFLSAGVWRMGSQSRRYNPRMPQGAPGAQNSRALQRNVSVRSTDTFGSRLSDKIFGRFGGATARDNCPSPSVYSPSPENNVPNSFGAAGRYMGLQGVDEDEDEDDLLDEKKHVDLDYDAFLADARVRDGTLAKSFARGDVTEADIFPTSELPYERNDVRQRYEARNGHPRADPFARPATPPFSVDLPSAPDRLQVSPKKTASTLVRPTAPETPDRAAAADLLLSYASPPLNPGSARPPLPPVPKQPARPRSTSPTKGALTEAPARVPFRQQGPPRLAKPTRSNDPFASIAAPLSPVERPIGVGSPMPAYEPSTTRRSEMSAFSLDAYGALAYSDAGHDEPVPQSSAQTEKRTSTQKLKKPKSRQRLADAVEPGTIVPSATSLQASKATTNTSSTKPRPKSAYAQLPSQRESPPVQLPSRNDLRPVSSVQPRLAGAFDPVFPDSPELKPLQHPNRVRAAVETFESSRNASKPSGHRKIESYDSGRSASTYQSSLARSATAAPTTGYRRPLGNKGLDSDEDGNSSDDSEAIKINRRLSRLILNRSRSQTQLATSPETEDEPGTPPRMSNDSKRLSAMLRQPSHLGGGFGADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B405</accession>
    <name>A0A2S5B405_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B405"/>
    <dbReference type="STRING" id="741276.A0A2S5B405"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="74"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="218" mass="24388" checksum="088845C25A645068" modified="2018-07-18" version="1">MAPSSTSDDSTKKSHDPPSEPPAAKKPKPDNLDAPNKPATMGGAHEQADKNHTEDDFPDVMPYNNDFDKMDEKFNGSCHCQSVQFKCKADPESSICCHCSTCQVVHGASSQRALIFKKENLAFTNESLKHLAFYQTHDKKVGRHLPCKVRCKTCGTLIADEGRNMYLMFPALFHFPDSKEPNEWAPTDHIFYSQRCLDIVRKDGVTFWSGAKGKSDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B423</accession>
    <name>A0A2S5B423_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative Thiamine phosphate synthase, or putative Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="16">2.5.1.3</ecNumber>
            <ecNumber evidence="16">2.7.1.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_5455</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="16"/>
    <dbReference type="EC" id="2.7.1.50" evidence="16"/>
    <dbReference type="EMBL" id="PJQD01000083">
        <property type="protein sequence ID" value="POY71534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B423"/>
    <dbReference type="STRING" id="741276.A0A2S5B423"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="15">
        <location>
            <begin position="27"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY71534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="533" mass="56761" checksum="C5D0B9842102841F" modified="2018-07-18" version="1">MPRPTVDYSLYYVTGRSLLPTTSTAPLDSYLDHLELALQGGVTVVQIREKDVDGREFYEVARRSKLVCDKYNVPLFINDRLDIALLLSCHLHVGQSDLPYQLARHLLGPDRLLGVSVNTPDEMLDILKPEHAGMVDYVGIGPAFGTQTKKNLNPVIGVRGVRDVLQVLGDSEIKAVVIGGITPETIPNVLAQTPAPLLPSADPTAASPTKYRSLDGLAVVSSIAASPTPDVAARELRALFAQRDEYTTRLERGGEWSAEKVVQVAAELVDLLRSEEKKPLMHHITNTVVQNDCANLTLALNASPIMSTVSAEAAALSKLLGCLVLNLGTATVPILEVQTIAGREANRNRKKVVFDPVGVGATAYRRKAASDLLNACHVSIIKGNAGEIGALAGSSEVQARGVDSVGPGFKDPVTVVRTLAAREKLVVGMSGEVDYVSDGHSTFAIENGSEWQGKITGSGCMASSAVAVFAGLDHESGPLVATLAGLLVINIAAEIAAERTTVQGPNTFRSALIDECHNLTPEDVVKRARIKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B441</accession>
    <name>A0A2S5B441_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_5415</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="PJQD01000080">
        <property type="protein sequence ID" value="POY71552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B441"/>
    <dbReference type="STRING" id="741276.A0A2S5B441"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015372593" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="336"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="384"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY71552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="492" mass="53884" checksum="82F51C7A432D4F4F" modified="2018-07-18" version="1">MRASTLLAGLASAAVVLASDVVDLTKSGQAGFEDFVQDSSLALVEFYAPWCGHCKALAPHYEEAATILKKDNIPIAKIDCTEAQDVCSGQGVNGYPTLKVFRNGVAADYAGTRKTDGIVSYMKKQSLPAVSDVTAANHDEFKSADKVVLIAYVDESDSKTQEAFKTFANQHRDDYLFGLSTDAATHSAANVKPPQVVMYKSFDEGRNDLEGSISEDSLFDFAKEHSVPLLDEISPDNFATYAEAGIPLAYIFVPSNDAKRDEIVDAIKPVAREHKGKLNFVWIDSNKFADHAKSLNLQEPKWPAFAIQSIQDMTKFPLDQSKDVSHDNVAAFVKDFVAGKIKPSIKSQKAPTQDGPVFVLVADEFDQVTNGDKDILVEFYAPWCGHCKKLAPIYDTLGEEFSNVKDKLVIAKFDATENDVPSSAGFRVTGFPTLKFKAAGTDEWISYEGDRSLESLREFLETNATNDILSPDDAEAELEGETEVKSGRHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B497</accession>
    <name>A0A2S5B497_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5428</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000080">
        <property type="protein sequence ID" value="POY71565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B497"/>
    <dbReference type="STRING" id="741276.A0A2S5B497"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="151"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="336" mass="35125" checksum="8E8C19D8052BFDB2" modified="2018-07-18" version="1">MVKAAVLGAAGGIGQPLALLLKTDPAIKELRLFDVVPVVKGVAQDISHVDTPAVTSGHVKSDDGEGLKAALTGCDIVVIPAGVPRKPGMTRDDLFNINAGIVRDLAQGIAQHCPKAFVLIISNPVNSTVPIAAEVFKAAGVFDPKRLFGVTTLDVVRSSTMSAQAIDKPNSADEFTIPVIGGHSGHTIIPLLSQSKPALPSSLFEDKEKLAALVKRIQFGGDEVVEAKAGGGSATLSMAYAGFRFAQQVISAAFNGKKGVIAPSYVYVADNKEITQSIGKDIAFFSVPVELGPSGVEKLHPLGDISPYEKELLSACLEELPGSITKGVQFIQQPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4B1</accession>
    <name>A0A2S5B4B1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000080">
        <property type="protein sequence ID" value="POY71551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4B1"/>
    <dbReference type="OrthoDB" id="2523521at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015449430" description="Nucleotide-diphospho-sugar transferase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="66934" checksum="26F30D7E7B7B4F98" modified="2018-07-18" version="1">MRLRLVAYGLAGLLFELVAVARLTTAATSSGNFSNATHLPLFPTIEGEPELPTLHLSLSSLLPILPHLAPGPEHTLAVTLATTAFKPLLYNWLCFLRYKAKWGQTPEFDMHGERKTAEDPYPDTPKLLVVTSDEDLALELSDLGVVTWLILGIDWEEWDEIDRMADDEPTKAEAIDNLQRAMADDLFTNLRLLDLIIPSVAPIEPEDIHKVVPWGTLRYQSLMLERTAVMSALVGALVESQRSEAAARKAEDADWRERALKHDWESGLLHREPFQGVKGVLMVDNDAVWLSSPTPFISHYYRPTGPYPAIVYAPDMSPHTRNAWGTHTMPCACFFYTRVSDDGAQQAAPIYLDPSSNEPMDPYLYSPAEGAAAAWRTTTLCHISMLWQALETGRRQASFLHTPDEGEAPLAISMPAMSKARAPSFQATSLGPALFLSEQLTIDMPEISHEHFLDAIGSGNLDDLHFLLDIAGLGVDPITADVHQSCLAQAQAYQRITPARKPTGWHERPTSLTLQYYDSLGAAGPRPHTPIRVEALPYDLFPPGMRYFDGGLEPGVRPCVVHANYATGNRKEELLRDKGMWALVRPEESDTGLWTCDAKVMRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4F9</accession>
    <name>A0A2S5B4F9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4F9"/>
    <dbReference type="STRING" id="741276.A0A2S5B4F9"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="306" mass="33361" checksum="E25589CD42A1BA1A" modified="2018-07-18" version="1">MTGLAAPAAAPTRLEYEIDSHKGAVHTAVYNSGASYILSGGADKQIRLTNAKSGMGVKVYSGHGYEVLGIACSYDNTRFASCGGDRNVFLWDVTSGDIVRRFSGHVGKINTVAWNAEASVLASGSFDTSVRLWDVKSQNRVPLQILEEARDSITSIEIKNHIICTGSVDGRVRTYDLRMGQLQIDFFDQPVTSLTFTADSSLLLVSTLDSTLRLLDLKHGTVVQSFSGHKNTNYRSQSCFGAREETVVCGDEEGKVFTWDMEAGSLIGKPFKAHERAILWTTHHPKERQLITASSDGKVKVWGPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4G0</accession>
    <name>A0A2S5B4G0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4G0"/>
    <dbReference type="STRING" id="741276.A0A2S5B4G0"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="69976" checksum="0328447B11A3F5D5" modified="2018-07-18" version="1">MAVALAPLAPLDTSNAPPSPTLQPIAKAPSVSPLALFAAEMMSWLWFAPGRTKSGTDREGGDEVPEVAKLQVQPTERFVRFCQEVLSTTQVSVSVVLLALLFVSRLKQQNAIEGAPGSEYRLAVTGLMLANKCLDDQTYTAQTWSQVSSLELKPLVAGEVEFLRGLDWSLHVSEQDYNAWLRLLQGHVASRNARLGKTPPLRSSASFATPTRRPTHNKRPRMPSPPGVYSGLGLTASWPPFRAGSEEVAIADAGGESGRRTRRKLDMSISSHNGGSASPPLLSGVPLSAPAAASSAPLPMYGHLLPNSSSSRSSALRRSTKEPSLTSSLGKRTATDAFGRSTSAGTSAALGLPMSTDTAAMSRSWSAGMPVHPGHPSVFAPQQPSLVTSCNPAVGEWTCPPLQPFAFQHGGYVSAASSPLQSRPTSSSMPACPPALALPNHLHPGSGFSTLVDSFSPRYDPEHYKQLQEGRVELGYYALAAGQGVGRYHTMHPVPQESHLGGFVDPFARYPSVPMHPAYPVSMSAASSPIARASRRYSPPFAFYPGQAVPTRTQPAYALSPLSTRPPSLATTHSSDHRRVSGESASSPLGSTTSTPLSMYDPPAPAPFLQATTPLRAMAPYELPPMYAGFAPSLAHLHPTQQAYSAYSNAGMPGVYWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4G9</accession>
    <name>A0A2S5B4G9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4G9"/>
    <dbReference type="STRING" id="741276.A0A2S5B4G9"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="105" mass="11056" checksum="DFFE9582C4099413" modified="2018-07-18" version="1">MAPASSASSASEGADDSVYQAKLASSLAGLPVRQGQHQQAQQAQNGTETAHGNGTKDAAPLSDTLDLAQTSAPSQADLAAQKLEQKRLEHEKQRALQKKAFEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B500</accession>
    <name>A0A2S5B500_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B500"/>
    <dbReference type="STRING" id="741276.A0A2S5B500"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="469" mass="49279" checksum="83E6264DA376AA6C" modified="2018-07-18" version="1">MPPKAIPASFWRGGTSRGLLFRAEHLAPYSPQIRDRVILTALGSPDPAGRQISGLGGGVSSLSKAAIIGVPGEAADLQREFGRLPGVEWADKGTRDGQAWDVVYRFAQVGRRAKGRTSDIARMAESRERDRTASCGNMFTAVSIAALSIPLLPYTTIFTRARSLPRSKQDPDAPIMFPLSILSASNGAVMRARVPIDPLTLQVWEPPAGQGVEIAGVPGKDEPGVMVEMPLDAASGRGGLVTGSARDTVRLEDGTEVVVSIVTSGLPNIFVPVSSLLAAAQTSFADGQTPPTLTPDLLALPASTLSSNSSLCHFLEQIRTSAARQFGLPLSLASPKITLVGTIPEAGYATTSGTTVSHEEADLLVRAISSGDWHATIPGTTLGALNIGMGTEGTVIHDVVAARRVQNSAQSRNVDDDDVVTIRAGHAAGVAESSVRFGKDGKPEAVAMVRTAREIMRGEVLVPERIFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B516</accession>
    <name>A0A2S5B516_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B516"/>
    <dbReference type="STRING" id="741276.A0A2S5B516"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="102"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="313" mass="35548" checksum="00B44C5E17DDA03C" modified="2018-07-18" version="1">MSKLLDRLKSSRQLRWIVPALVVDWLVVVILNLISTWVERQYPYERDPARYLDDPSLQWPVTKERVPAGPNTWLDVYTFWIPIAVVVLVGAGVKRSFHDVHHGILVFLSSRALMRIIVECLKNRVGRLRPDFFSRCQWDAVAQACRGPLALVKDGRRSFPSGHSSTSWQAMLFVSLYLAGKNGAFAFAAPFPRSGFLQSRLLRFVIVLAPLFLGTWICVTRLEDHRHHPTDVITGSLIGALCALIMYATYYPSPFIFTAPPGGHCEDELSVMDKPRRVYGFKEADERDAWAYAEEGRVRLVEDAGEEEESRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B529</accession>
    <name>A0A2S5B529_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B529"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="394" mass="43426" checksum="0F10D34904C7BD1D" modified="2018-07-18" version="1">MSAIQLTSAQLAERALAANAGLGGTLGASWSRRVESGEARPYQACSREDRSWGHVNGADSVESDTDEEDDDDDDDDDDDDDSSSFVSDECIDEQFLDPTSPRGIATAVMGRAEAVSPVALYRLHCFDRDTLLQANRYAEHCWNRTYTLEALRDSELLTASQTLLSEEEWDLYLEHHGKRDEDELPYAAHNTALRTRPEDSHLVSEQRSGNSTPTPRPGPPLLGRATSSYTGVSADRPAPAEPVASAYTPRLREAGQSSSARTPTPRRRVASQADGPASMTEEARQELYELYQYASDGSGYRTGPGDGDGDALSNGLRQIDLDPLGYSHRGATLDEVEVEEELYEEEVEEETIEEPSLELHDPRRCDDPEAEAAERERDSQEARRRLSQGSTVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B538</accession>
    <name>A0A2S5B538_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B538"/>
    <dbReference type="OrthoDB" id="2528416at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1380" mass="145557" checksum="3C66BBF73FD6DE59" modified="2018-07-18" version="1">MGEPPIQLHDWFAAVAQSLLPGDRELAVVFHGRVETAEGLDTRPTALQLVKRLGSDAFRTQWGGQPRTVKLVGPLARERAVAGGIDDVAIATFKDGISPHIEFFLHAAREHRPTKVNLRAAFPPPAKEPTSTAKSQPVSAPRQSPAPRRSAFLNFGGGHDEQLAGAPGSMHELAEGLRRARQLRRPVGSQPRSANFTEERPLRQPDRDAGWARRRVAPAAQALEPASASQEQPSLPQSTASHTSQETVGIPAQSETLPELPPASAKAGLDSGDMPTQDAEMRDATTQQSTEPIPAHPAGASTGGPQVAQLIRIDCKPKSLRQALAGTVVRFFAASYTPRQESASALHRDPPSSKGSPRTETAVQSSPRRGVLHISRFQANVTAALQRSDPLRASSEVPALELHEDVAQAGGAGDTDAEVKYAEAAPIAVDTHSAEAGMICPMATVDVPSGEPSQDGLTSSPAKEGPMDQTEVPATEDDIKPVATLKRRASASPREQTEKVVPSESSAGDMPAPAAKVASSLAVTFADVEPSSDRHSSVEPAFRSSQGFSSMYGESEPEDDDDDVEKAAEEISAFIARDLASSIVDEEEDAERAHAVGKRPPVDVSLPVNSTSTVVSADAGPAVTDAAVDLPAAAAEDMPAMRTTPSRNQGAAVVDSDIHDVPGVAVRAAGGADIAPTCAASEIEPAELQADAPPASAGLEQDSPHPVEAPSPQPLPPSDLPIAMPIPGAAEPRLPTPPFSPLPVGVSATVDDYYAPEEPKDAYFAQDEGFALASVSEEADVASQAPSGVSHEALPAHSRSSSPADGFSPRHTQEPRLFRDASVELYADITDEGALAALSALRSSPASTPEHAEKSSRGSSVDVFGQKRYLHEPGSASQPATSTRARTTSAGGAKVSQPDAVHPASDGPERSRQAATKKRKRRGSPAFTLEIFASKSPRKRAAPARPPLEPAQPVASTSRVTLDDLADGSPDARDSRAPASQSARSTAELERQTKGINARRPDMDEAVALDYNSDSDDPLAVPIRPVRGRSPSKGIRPMGRVALTRSDLSDEGDSDEEEESQIVQRALLAKASRLRATPTSADDTTTRPRDAVAQPRNGRLPARRPPLAQRDLPKPPRKPSLAGKIRPGDPRTSSQGAPARPRITPRSAPLSNERLQNVPAAAEAAPPSPFSRPSGVRSDVAGPIRRKRPRSQSEASSYDESESTPPIVARQGPPVQKKSAARAQARGSARDKVMQHPRGPSRPGTSPMGRPRSSSRDSVEIEDGDDGPLHVGKESGNGSEQAPTPARPPPTEPKSTKKRKKRKSIVMPRSKGRRRPSTAMSKPTNARSPSSELTASPEPVPRASATKAGSKRRRAEAGGRGSKKARQAHDHAEWGEDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5A8</accession>
    <name>A0A2S5B5A8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000064">
        <property type="protein sequence ID" value="POY71946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5A8"/>
    <dbReference type="STRING" id="741276.A0A2S5B5A8"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="109"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="485"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="595" mass="64239" checksum="CC82884560DAD69B" modified="2018-07-18" version="1">MSACTPGSLLHPAFSNAPFSLDRFTSNTNGTAPATAIVHEYSAIGPQPGLQAANALGGATDRDASGAQLEGQDWRGGFTGGSSVGIHSAPRVSYYFPKGVGEYHFGERHPMKPHRLTLTNHLVIGYGLHRQMDMYQPRPATKDELEMFHDEDYVDFLARVTPDNVRHFTSVLSRFNIGDDCPIFSDMYSYCQQYAGASLMAARKIVAGTTDIAINWTGGLHHAKKSEASGFCYVNDIVLAILELLRTHTRVLYIDIDIHHGDGVQEAFYNTNRVLTVSFHKYSPDFFPGTGHIDELGHALGKNFSLNVPLQDGIDNESYVALFKSIMEPTIQTYRPEAIVLQCGADSLGADRLGCFNLSIAAHGECVRFIKSFALPLIVLGGGGYTIKNVSRCWTYETAVLLGQEQDLPNALPHTVYDDFFAPDWKLHPELASGRNRLENCNSRESLERIRSGILERLRYMHGAPSVQMSEVPPSLASWIADEDELDGDARGPSSAAGSAPGDYFGGGLASQGPAPPPPPARRPRMTATGASSSAVPGRTPGAGGGADNHNKKRRKATSAAGPESGAFAVPRQRMSMTGKAARPKMDAGGADDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5B0</accession>
    <name>A0A2S5B5B0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5B0"/>
    <dbReference type="STRING" id="741276.A0A2S5B5B0"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="91" mass="10460" checksum="ED303E9CECDE1F9D" modified="2018-07-18" version="1">MEPLVSERVYIKWGSDSPDAVCDMSEQVLVIQGRTGFYLDLRWRREAQRDVLTWATAGWKTIEAPREGEARRSRALHTSVRLAPGDFTLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5T1</accession>
    <name>A0A2S5B5T1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000059">
        <property type="protein sequence ID" value="POY72095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5T1"/>
    <dbReference type="STRING" id="741276.A0A2S5B5T1"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="112"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="212"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="301" mass="32081" checksum="81EE17C16A34DBE9" modified="2018-07-18" version="1">MSASTSSSTLTSAASNGMAASGSKALPPRPKSYPFWLGDPLDLAKVRMQTQKGKGFIGTVVDSVKADGLRRGAYAGLSASILRQMTYSVTRFGVYDELKKRMQARHPAGTPLSVWEMAAAASVAGGLGGLAGNPADVVLVRMTADAGRPVDQRLGYKHCFDGEFRIIREEGASALFRGVGPNCARAVLMNASQLATYDTFKSMILSTGLIGDGIGLYFASSFMAGTVATTVCAPFDVIKTRIMNASGQASISTVIAQSFKNEGMSWMFKGWTPAFIRLSPNTIIVFLTLEELKNFVDKMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6A0</accession>
    <name>A0A2S5B6A0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PSMG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6A0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6A0"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="334" mass="35202" checksum="31D36CAE5169A8CC" modified="2018-07-18" version="1">MSFFVPLRGSAAPSFTSATLVLPHRTSNGRRVQPQPSLASLAQLACDLIVHNYRLELVGYLALQDHVPAVGARDSLPGQPAQNGIALGCEVFATPDRSLFIALPRSPVIHARRANYLDSIERWIAQSGFKEVLVVAGADAAMRGDDGLNEITPLRHLTPNSSASTSSHLLTTLRQISPSYLTSAPSGFQSTSEAAALPSDSIPPIPHGGLTRQLLTTLTTAAPSSPSRSDSPTAPKVDIAALLIYTSEGAASESAHFLADALSYLLEPQLAALEDRVERVSPTPASGGIRGGEGETGAAQGSDKGNVEWKEPISWERGLLGPELARDAGREMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6F9</accession>
    <name>A0A2S5B6F9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6F9"/>
    <dbReference type="STRING" id="741276.A0A2S5B6F9"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="443" mass="48081" checksum="87600CB9A31CC4A2" modified="2018-07-18" version="1">MVQLNNTFEQLRVSDAGPAQQHRPSRPAKVALRVRSGAEDAQGEADAGADSSSRLLSLLSRLFSPLRRSPNFSSTLQHVKGLLYEKEYLAAFGTDTEEGERWREVYAARWVPARAVIYERIFEECGIARHLGWDTTAVQVAAREQTEEEELAADRQRARLRRQLRQEGRTGAEIDAAVAKLDQELLASRTGAGMDRGDDGAGATVETVMIGAGAGSEVVALGAVLGQAALASERETTAIAPKRPRVKVQAIDQGSWDVLLDKMAAGLREDWPVLGSAGGDDESAEEAFQVDFIKGDVLAKAPAGDSAATPLSALPDFSSPSLRLVTICFTITELLLQSRVATLRLFSDISRSAPRGTLLLIVESASLALIPLGKEGRTYPLGKLLDHALAGANGDGAWEVVESEDAKWYRMPEDADEVYNEMGKGTRVKLENSRVVLRLYRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Y6</accession>
    <name>A0A2S5B6Y6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4352</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Y6"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Y6"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="12">
        <location>
            <begin position="307"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="575"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="615" mass="67254" checksum="32CBC865C6DAAE1A" modified="2018-07-18" version="1">MVQSPNLPAGYDEDYDEPEELALPQGTEPTNDASRLEGNGSDGALYHAGAAAEEAQTDQNGQSGRLEQHGGQHDGRDAGQGERGQSTPPAAGHAVAPAAASGQAPSHHPLPSRPVPSSLPPKPTGATGPPSSTFSHAGAAAASAPAAPPSHAAPPGSNLPPGFTYNPALHPPRRHDLPVPEGLPGDRVADMDVEKYWTLRGHLNELCGISGTTSQPISFDLESLKVLEEEDFWVCEKSDGVRVLVLIVATGFGQEVYLIDRKNDIYQNYWLTFPHQDGEEYNHSNTVLDGEFVIDVDPVSGKHIPRLLVFDLLVLDSENVMHRPLEKRYGRLGSYVVKPHQKQLAKLPPEVRQQQPFEVILKKQELSYGIEAVFRDHVPKLLHGNDGLIFTSAEAPYTPGTDRKILKWKPPSENSIDFLLQLKFPPRADQPSEPDFFAKPMFMLMMNHGHEGNHYYDVMDVDDDTWEEWKASGEQYDDRVVEVVWDAARSTWKMLRFRDDKFEGNYKTVVQSIIKSIQHGVEAEQLVAHAGRIRKAWKARQAARAEQVKREAEAAAAAAAAAAAAQEAHGSYTGQHYADPAAQHHPQSSVPANGQSYPSAPNGRPPATTASMLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B704</accession>
    <name>A0A2S5B704_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_4391</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B704"/>
    <dbReference type="STRING" id="741276.A0A2S5B704"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000270">
        <property type="entry name" value="Non-structural maintenance of chromosomes element 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="17">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="334"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY72564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="442" mass="48347" checksum="0EFDD36A98BAD0E3" modified="2018-07-18" version="1">MAVRGTASQRRGRGDESDTDDDGSGQPQAGSSRQRQQQNGGRAGDNANKQQRDPELEALKLDKPDKTLRHLFLQTLMSRKVIPLDTAKTLYKEQCRLCKVQQPDAFETFIAELEPGLSLCGLDIKTTRNQETGVPYIALVNTIEDDVSKLATDYKAEEIALFRAIVEKIMTAPKLSYSTTQTEAVRLAKAPVTKAMAIQLLKSFLAKGWLSLHSSGRLTLSPRSLLELAPYLRETFSQGTQEDDDDTPEYERDRTVVDCNLCMTIVTSGYACPNKRCGVRLHTYCATQRLGNDGRCPDRLDETKEHPCQQTWPRDSSTRKFYGVPVGISAVEDVVGSDDDNGAGPDASSMMASSSAVKTQPKKKAAAAAKGGKKKAAPSKKRGRAAEVDDEDEEDELDDDEDASSRAGGTSSPTAPRKRSSRTAARRGTAARMSEDDDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7W5</accession>
    <name>A0A2S5B7W5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4123</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7W5"/>
    <dbReference type="STRING" id="741276.A0A2S5B7W5"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="96"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="633"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="763" mass="82056" checksum="58A560A5C0D7D79B" modified="2018-07-18" version="1">MNNPNGGGVLPNLPSTTLAPSLPNVGEVLDPEVEELWSSRALLLSAGVETLAGHEWLPGRPADPAQQHEQPTRTPSASFSSPIADLQHVLLLLILSFWVSYYLKVRRIRSIHETIVAMFSGMLVGAIVRLAPGHVVQDMIAFKSTILLNVLLPPIILNSGYSLKQESFFKSFAVILTFAFAGTFISAVALGVIVYLYSLLGLEGLSLTIVECLLFGSTLSATDPVTILAIFNALHVDPKLYSVIFGESLLNDAVAIVMFETLSQFHGEKIHVLSFFHGVGIFLLTFFISMALGVLFGLSCSLMLKHSELGRYTEIEACLVFLIAYTSYFFSNALTMSGIVSLLFCGITLKHYAFHNMSLRTQRSSRYMFGSLASLSENFIFIYLGLSLFTQTELVYKPLFIVITFIAMCIARHAAIFPISKLVNLFFRARGARDDEIPKNYQMVLFWAGLRGAVGVALAEGMRGQHAIALRTTVLVSVVLSVLVFGGTIQRVVETVGIRTGVIDEDDEETDDEYEFLAEQDGESRHRKKLSLAHGTPGTSHHFATMAGRSFGGGGLPPNAEFDQVATPRGGRRARHVPGARSPNSVSSASDDSDPDILPSPTEEATLARPGGLGAAWSTLDETYLLPVFSQPTAARSKEAKKKRLSRSPVEEEEGRSPYGSGGEGKSKSLADVVGALVKPALGGGSASEPPSRIPMTPHLYANPSSPYPSTDLTAATSARDRGHTPSGSYSNSNGPAAAVKPFGGRRSSGRGESPGGEGGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7W6</accession>
    <name>A0A2S5B7W6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7W6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7W6"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="50"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="353" mass="36213" checksum="E7338FD40B2C2AF2" modified="2018-07-18" version="1">MQSRTQLLTPSALRLDSRFPLELRSLSFEILPAPPASSSSTSTISTPPAHADGYAVASHGLTTVSSSVFGPREAQRTGAWSGGAGQGSGAGAGGGGGGATAGGAQKGDRAQVNVEVGIAGWAERVGQGAANEGGVRRAGKDRRTIEIAAAVKNTFEPVLLLHLYPRSSIDIYLQVLENDGSLLQACINATSLALISAGLPLSDYVCSLTLASHPSLPPSGPPQIPPFELVSPPVAHSNANDPTATLGSGSTTLLDLVQAEEQALPSLTVAVLPRSGKVTLVNLETRVGVGRFEEMLRWGVEGAKIVQQAMEDAVKEWADGLAKPQKALGNLFPGLSGGAKGGAGRDEDDEMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B805</accession>
    <name>A0A2S5B805_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B805"/>
    <dbReference type="STRING" id="741276.A0A2S5B805"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="194" mass="20888" checksum="0904380C064CE9E5" modified="2018-07-18" version="1">MAESSFRQSLQGFRWAQGVTDDSQPATEQSAFARFTSALSSGIPLRSTERSNEEEAYFALSRWERFVGFLLCIAGAAACFVVSFFIGLPLLAIKPRKFAVAFSLGSILFMVGFGVLQGPLAHLKHIFSAERLPFTAAYFGSLILTLIFALVKHSYLGTLICGAIQCVALVSGGLQTLSYGSRMAMRGAGSLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8K5</accession>
    <name>A0A2S5B8K5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000041">
        <property type="protein sequence ID" value="POY73112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8K5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="236" mass="25413" checksum="52D04A5B7168A7D1" modified="2018-07-18" version="1">MDAGHHNNQSPAPVPAPESTSLQLASGEANPQQCLTPPSVRRREARIARCMMIRDARRAAAAAEGEQGEPSRREPTVRHAYTPEEVRIRRRDHHREQQRILAAAAAATGGDHLDRFYGRQDPATEHDPALLIRPDGTVDWDAAPRTLPTEFDAATLATLQDTPALPRRGLAEAGPLTLAPAGIESSAGWPSPALLLSAVLLVVLQIAQGRRSRRRSSAAEADAPARKYSAARPPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8V4</accession>
    <name>A0A2S5B8V4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8V4"/>
    <dbReference type="STRING" id="741276.A0A2S5B8V4"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="156"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="637" mass="70717" checksum="94D0F465425045E3" modified="2018-07-18" version="1">MADPQRAAQLVTDDALTSRGLAGQPDLVLASDERDVHGNLGAPPYSAAASGRYSAGEFELTSSSVKGNGNRYTDQTDGEAETSAESDHHHARFRSRAASTGSSHVRGGSYSRIELGHGSPRRRRTGASLAEARDVEKLDERTLRILWWRSAAINVLYILAWYCFSMLISLYNKWMFSEEYYNFPYPLFVTSVHMLVQWILATITLSLFPRLRPKKRPKPRDYATKVGPCGIATGLDIGLSNLSLRTITLSFYTMCKSSSLAFVLLFAFLFRLETPSWRLVGIILIITAGVILMVSTETQFDFVGMIQVLSASALGGLRWSLTQMLLHKESMGMGNPIATLFWLAPIMGATLAFCSIVFDGWSNVFSHEEFWGSLGRTLRTCLSITLPGVLAFLMNITEFGLIQRTSVVTLSVAGIFKEVAVIFVSTVLFHDQLTPINISGLCVTIFGIALYNYLKYRQYTQDPSKQHQHGPPMTHGGFDDTTEEAYDEGQPMLDTSRRTRPDESAAPTPTAAGPHHSLGDEDDEDEDDVRDRDLVFDADADFDAQSLDAQASQLLGDFEEESARDDHLVRLSEADKARQHDADRIPELDALLKEDDELRETERGAKRLETELEQATRAGAKTRDLIETGEETEGPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8X6</accession>
    <name>A0A2S5B8X6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_3566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 13"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8X6"/>
    <dbReference type="STRING" id="741276.A0A2S5B8X6"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY73233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="520" mass="55186" checksum="C6EECAB5A012AB32" modified="2018-07-18" version="1">MTTVASCPGKVLLAGGYLVLDRQYRGFVVSTPSRFYTVVRNAANSTNATPSTSGEVDESFPIKVVSPQFDDGRWDFVAKREGGQWRVDPVVREGSSSNPFVHLSVQATLQLASALQPDATFAPLDITIVGSNDFYTQSREDTAPRPFAPLNCTIRNVHKTGLGSSAAMVTSLTSSLFLHWTAGASSADTETALSEAPTSSRLPGPDAATTQLLHNLAQYVHSLAQGKIGSGFDVSAAVYGSQTYRRFAVECLSDLLDRGSSPVLADELVKVLAPGQNAAWSDEATSGSVTPFALPPHTLLLLADVDAGSNTPSMVGKVMQWKKAQPADADRVWNEVARANEGVRDACAALTAAARKDEKAYVDEICRLASISASEWSSSILPVRAAMESILRTRALMREMGEASDVPIEPREQTRLLDACSALPGVVGAGVPGAGGYDAVWVLCLDPASSPSTHASEDNSARPVAAVEALLRSYKEMSVGPLSQSAWVRGGTFEGEAGLLRERLEEVPGLVQAIERAGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B964</accession>
    <name>A0A2S5B964_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Laminin IV type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3647</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B964"/>
    <dbReference type="STRING" id="741276.A0A2S5B964"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013015">
        <property type="entry name" value="Laminin_IV_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51116">
        <property type="entry name" value="LAMININ_IVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Laminin IV type B" evidence="11">
        <location>
            <begin position="243"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="371" mass="42173" checksum="E0FA1B7DFCF7B014" modified="2018-07-18" version="1">MSATTTVTQSALTLRATEEKKASTGSTRPQKLRWWGETGESEEAYPYRHFLPFFDKELRLPPLTPFKHFDPGHDALKHEDPQSFLAHADVDELTPDFGSEVSGIQLHELDTVGRQQLALYVAQRGVVAFRDQDFADQDQTWMIQDWCRFFGRPHIHPCSGAPKGHPEFHLVYRDAKAVYNYETDSRLTSTVWHSDVTYEEQPPGLTLLFLFDSPASGGDTAYADQRGAYNHLSPSLRSYLETLSAVHSGVEQAEYSRGGNRGGVVKREPVQTIHPIVRRHPVTGEKALFVNRQFTRYIVGLKREESDALLELLYTHIERGTDFQVRLRHRPRTVIAWDNRVTAHSAIIDFAKGGSRRHGARITPQAERPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B968</accession>
    <name>A0A2S5B968_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B968"/>
    <dbReference type="STRING" id="741276.A0A2S5B968"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="715" mass="77606" checksum="0C8281F8C9DF0404" modified="2018-07-18" version="1">MAAPLLDAAASSEPKTRSYSGCYSCRAIKKKCLEDFDSDGKCGRCISRGVHCERTKPVRRPGGNPHGKRSSNAGADGHLDGSASPNARPAKQPRTANGRRVAGQNGEPSTTPPSLDDLSTVALSMAASDPNSQNHHMYNYAMHLPIPPPIASTSAVPYSAPSPAALALPTPPPILPSAPSLTLPMPIQPPPPVLPATTPNGADASFPLSLPCNPWDQMFGFLESDPTATLAVDPALPHFDWAALTTGQDLQSPLVSETSARSPPAPKNRQAKLPTGMETILNGLASRSSPMTTDATSPALSYTPGSTNAVADDSGDLELTDDMLLIYNALNAEFLNLMPIADRERAAKAWTDLARSTRLGRTAAAACVWLYLARSSRTVDPEERTHLLAQSDRYFQRAVAQLSDEVSLNSQIFALLDLFFVQADRTSIQSGNALLAIGELFIKQAHGPRPPLDLVNHSSASSLRMFAVLDILRCAVEKGRRTVFDLEGLPGCLRASSTSQPEGKSSDEADNNWQVIQWSGFPLELILCIAATVNLDCDRSVMTPEAVQAVADKIEEAIKTWNPARSQAAGYEDSLTYLQEAATKEMWRHATLLHFYRVVRQFGCLARPIQDSLYQILHIGQIRRPPPVTKPVTEPVFDFSRLWLRAFPWFMAATVATQPAERDLCRAGLKNYWSGSIIEENTKAAEQMWAEMDETGRDNDFRDVLQRAGLCAAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B997</accession>
    <name>A0A2S5B997_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcineurin family phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B997"/>
    <dbReference type="STRING" id="741276.A0A2S5B997"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546:SF4">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="462" mass="50395" checksum="EF020A55C7118FC8" modified="2018-07-18" version="1">MPATTAGSNRPLLLLTVCIFAGLYYLSKNSGALQISQKLAAHRAGTLGNQAADRNRANTAAAPTRSAAPGRASEATISQRIVAVGDIHGDKPAAMEILRRAGLVDLRGQWVGGPDILVQTGDIVDRGPDTIALYKFFQTLRPQAEVAGGAVISLLGNHEMMNALNDWRYVTKEDIASFGGERNRREAFSTGWIGQEFRTNYSITARVPYLVEADAFPAEFAVEAPTLPKTPRGSSDRRFVGDPTYAAAFDSVENPFRLAAASFVHGGITPEYLASLDSDRPVFEINRLGHDLLFSLLSVPGQASLGLPRTAPPEQREFWSERGPMWNRDWALEDEDEICARVERACDMLRVRHLIQGHTPQFEGILSRCDGKILLIDTGISRAYGGAHSSLSITYSLTPATSLAVQDALRLKLVSPSDPDPETTLAALRGVWVEKELVEALYTKGRATEVLVETERVLRKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9J1</accession>
    <name>A0A2S5B9J1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_3387</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9J1"/>
    <dbReference type="STRING" id="741276.A0A2S5B9J1"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="10">
        <location>
            <begin position="522"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1025"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1120" mass="121780" checksum="D6BDB69BB502D531" modified="2018-07-18" version="1">MPPRRPQNGAAPPTAALAAPAWRQFSFWSCSPLSPSSPLADWLNQPALVSCIHADPAIGPDGIVLVADLEGNLSWINEQWGIEKTWNAYAGSHARVHAIETREWDPVQGRAIVITVGEEPSSQFPVLKVWLLSHTTSDDAPHLTLLRSAPISPTPGRPVPVSALAVSPTLSHIAVGLADGSVAGWKRVDELIDSSLYDLEEAAARANEPPAGMVVASTSKLRSVVGAGGSKAFQPGGMGKLRVFWEGNKEPVTNLGITVPTSAPTPTLFILTTSQILAMPLATKSKAQTPPSVLDDHGAAVGCAKVMALGGGKGAADSDLAVRMVVAREEAIYVYGTDGREGCWAYEGPKSSIRALRQISVAQPTHRTATPLPTPYLVIVSPPLTASLASNSATIRNHAAARSSASTDENVAKVTLFDPENKFVAFTGTFGDAGEAEMGGVKEVIEAWGAVWVLTEAGKLFRLGEQSLKDSFSTLYQRNLYTLAIGLAQSRGVGPEEVAEIYWRYGDHLYSKNDYEGAMAAYLKTVGVVQASYVIRKFLDAQRLTHLTSYLQELHSRGLANSDITTLLLNCYTKLKDDEAISRFIHSSASDKHEGDEDTPPFDLETAIRVLRQASYFSHAGWLAERYHAHGEYLRIAIEDTTDFAGALRYVQQLARGKIGGKDGREEAEESMKRWGGVLLANEPERTTQVLVEICCGVEKQSSPTKPVDVKSSLTGYDVQDNDSVATSVATATAPATAQPEQLPSPRAFFVHFVDHPQSFVVFLEEVLRRRFGKTLASLTPPSSLVGNEAPLPEPADPTAPSALRDGATRDEQALWNTLLELYVTSAAADEDSTSASKALKLLRCRDHVPYDETQALLVCTTHGFEDGFVLLYELLGMYEDIVQYWIDASTAEPTQKALSSRVIRSLRRYGSSCPSLYQTVLGFITGSSDLLSRHQTEVVEILDEIDEREIMPAIQVVQLLGKNNTASLGLVREYLKRQLLAEKQGTDSDQALIASYRSETAKKRKEIQELSDPNAPRIFQVTKCSACQGQLDLPAVHFMCRHSYHQRCLGENESHCPNCARTHGVIREIRNSNAQLAGKHDLFQQEVADSQDPFATVANAFSRGWLGYQPQDKRNGTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9M4</accession>
    <name>A0A2S5B9M4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_3409</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9M4"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="91"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY73472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="265" mass="28411" checksum="2CC63071AE5F5DFC" modified="2018-07-18" version="1">MPVPPAGATQTADHIDAVEDTPLLHDSRDPAETDDAMRSNQQSGAAPSALELLGRNSCTGVTGWAAQIGLVLATVVLWRVLWVHPAGLFSYHPAMQSLAALGFLEGILLLQPIPSNAQQKRKGLQLHQAFQYASLVVIVGGAAVIIYNKAIHGAKHFTTWHAKSGLTLALIFLQITFGAAMVYTPLQNALFKSEARAKKVWKYHRLSGYLTLAFLTLTPMLALASDWVRNNSTAVERALIGTGLGVAALAAFARVQTSKLGLKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9V7</accession>
    <name>A0A2S5B9V7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9V7"/>
    <dbReference type="STRING" id="741276.A0A2S5B9V7"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="264"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="264"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="346" mass="39675" checksum="5CEE8B7E5F2A3C05" modified="2018-07-18" version="1">MAMMLRALARTGTTLAPAPVAPHRLANIYTAVTAVRSSTATGTWSHGRYLTSSRIANERASSSIGSGQGGRADKDKRLRDKEREAKEKLKAKELRTKEKERKDKEKEKKQLQRVRDKEKREKEKEKRVRDRERARAAREKTKATETKSKTRSILRLPKVPQNTWQIFLEEYITEKKQQLGPGEKLPSVTVLTKDAVPRYRSLEGAEKQALQDRYQAARDAYPAILDAWQKTLTPEMIRKENVVRANRRRLGLSRKRALRIDGEPKKPLTPFFRFCNEIRAEGANSSVLQGETDITKQSQLLARAWKALSLEELKPYQDAYAGAQEQYKRDMAEWSAEQERTAQLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9Y2</accession>
    <name>A0A2S5B9Y2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9Y2"/>
    <dbReference type="STRING" id="741276.A0A2S5B9Y2"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="98"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="611" mass="66083" checksum="C04818B83BDD8729" modified="2018-07-18" version="1">MSSFDAEKDAYAKNEGETYVSSRTAGSVSPVEGGARTELYDPSKESLATRLGINFESFKRAPGATGGHVADGSAIDPLKGHENPMLQQKMRPRHLNMIAAIGTGLFIGSGGALNRGGPLGVLIAWSIIGVMLITVTQAIGELAILFPVSGGFYTLAVRFLDPSMGMACNLRRLTKPLTGAALGWILPPQYFLQWFATMPLEITAAGITVQYWEAAAKVDIAVWITVFWVLFIIVNIFGTLGYAEEEFWASLFKLAVVVIFIIIGIVLNCGGGSGEYSTYVGGRYWRDPGALANGFKGICSVFVTAAFSFAGTELVGLAATETNLPTAVKGTFWRVTVIYLSTLLIIGLNVPYNQETLLGGGSGAGTSPFVIMAKLAGLNGLDHLLNITVCISVLSIGLSCVYAGSRVLTALAETGFAPKCFTYVDKSGRPLYSVLLLLAAGPIAYVNCSAKGEQIFNWLLALSGLSTLFTWGAICMCHIRFRKAWKLQGHSIDELPFRAFGGVYGSWLGFILVCLVLIAQFYTAVWPIGGRDPDGKKAAETFFLSYLAAPIFLGLYAVAFAIFRTTPKRAHEIDIDTGRKSWFTAEEMNLWRAERKQAPMHIRIYRKLFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAB3</accession>
    <name>A0A2S5BAB3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAB3"/>
    <dbReference type="STRING" id="741276.A0A2S5BAB3"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="504" mass="54327" checksum="38B342EBA5EC4670" modified="2018-07-18" version="1">MSSFRRRTTVQPIAGTRPSPYNAAPLLSTGLTSIDDLLGGGLPLSTSLLIESDSPTTYAELLLRYWIAQGLECGQEVVVVASGLDGGPQAIVEALMEVDGGRPVNESTVGMSRQDVQEDEEEKRQEEALKEQMKIAFRYEGLKQHQTTIEASVQANANGAHCSVFDLTQTRKLSDSDRALLHLIDVDDLSSSSSMPSPYEDLYRRIEQIVEERGVRQSSDPAAPRKALRIALSGFGGPLWGSAPSAALYSFLHRLRHLLRQAHASCVTTFPGYLYSSHTSSSAPLSPLLTRLSHASDGVLRLSSFAASPTLSATFPRHAGLISFPKLPTLPPGSLVPPGSKLSVLRGLGGGGEGRENLIGFRVKRRRFVVEIVSDDPVAGGGEDEAKERRRKRVEEANRKEREMAGGKSGTEVLLGLPSRVAQVRIGGEEHQSDEQTLPPPIPIAASDAAPAEAAPSSSFRPARRKGVRVGGVQFANEVDAEPARPKKVSVARMVHEQPDLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAE8</accession>
    <name>A0A2S5BAE8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAE8"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26627" checksum="02B43FD349B8CCEC" modified="2018-07-18" version="1">MGNCCVCGKETAQRCGPCGRAGVDLFFCSTVWPAHKQVCGPNSNPFCAPDLSREEASWLRQVARTSLELTAAEAAQQAGELAFGMKNTVAETLEAAFCLGSGGLEKLSDEDLMNLSSRPMPGSPSRPEINLCTRALFNWACRKAGVLASVLQSALHHAVVLELLISLRARSPSPPFANSALSNGNLARLLECLVQPLLPHCHFASDSDWQTVAAFFAAPLLTIGVDVVRITDAYNHASGVVERYSVQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAF5</accession>
    <name>A0A2S5BAF5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAF5"/>
    <dbReference type="STRING" id="741276.A0A2S5BAF5"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08577">
        <property type="entry name" value="PI-PLCc_GDPD_SF_unchar3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039559">
        <property type="entry name" value="AIM6_PI-PLC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="318" mass="34680" checksum="22977D41ED64B532" modified="2018-07-18" version="1">MVALPFLAHASPESFAANSQQQASTILARSSVAALAGLSFQSGMSALSFPTDVTRDIQPKNVHSHNDYWRKVPLFDALSYGCKSVEADVHLVDGELLVGHTRVSLAHPRTLHSLYLDPIMEILKMQNPQSSATAAMTNGVFDMDPETSLQLIVDYKTGGEELHAAIIDALSQFRSLDLLTNVNTSNPDAPILNVRPLTVICSGNCPLASVNAQTPRRDVFLDAPLADIANASYTRWNSLMASTSYRKLAGWAGSFEVDEQMSTEIKGMVKAAQDKGIKTRFWETPGWPSFARDSVWNSMLNLGVDWINADNLKAASQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAI0</accession>
    <name>A0A2S5BAI0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF423-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAI0"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="12748" checksum="ED0EDDA7743CA0C2" modified="2018-07-18" version="1">MPIFPASATLAWKAGALLTSSGIMAGAFGAHALAPRLGDKAATWGMASQYAILNGIGLLAISQHPVYSKRLATPLIIAGTTLFSGSIFALLLYREKMGALTKIVGPSTPVGGVLMIAGYLSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAM9</accession>
    <name>A0A2S5BAM9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAM9"/>
    <dbReference type="STRING" id="741276.A0A2S5BAM9"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="444" mass="45671" checksum="66280CC41333C358" modified="2018-07-18" version="1">MATFSFGAPPAAASAPKPTFSFGAPAQLSTGLFGSTAPAPPAAAASTSLFGSTTPAAPSSGLFGGAAPATSTSAAPPSTGLFGAPAQPATGLFGSTATAPKPSLFGASTSLFGGAPAPGQQQPAQQPMSLFGASTSTTTTGGNSLFGQSQTAATASLFGSKAPAPPPPQAPVPKLGDPLPPAANEPPIEQRLVAIKDAWDPTSPTCRFQTYFYNEVPQGQSAQMYSRPVDGARRDEWDRATRENPDPESLVPALALGFPAVQTRLDLQQRLNLQHQGLLDQIHSHLDSLSSTHSLTTSLRTLRARQNAVALQARVTQLVARAGALTPARAASLRRDEDQLRVELEAMRTDVEAVKARTGELWAGVGALRSHEGTAESAGSEAAAWAVSDEEGLAKILEILSSQQSGLDHLTRTLQSMAKDVDVVNDAFGLPVGKVVGKDVVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAS3</accession>
    <name>A0A2S5BAS3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAS3"/>
    <dbReference type="OrthoDB" id="2528626at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="342" mass="36337" checksum="C44509462A29C37C" modified="2018-07-18" version="1">MKEVSVADLEGELSALSAHVTAMASALDSLFELRRRPISLGPAFPASDLAALAAQTSELSEKLLSLPSAFTLTAQRLLRLESLSALNQIAALESELVTLREQFAAASLEARQTVVERIRSEAWDEVDARDSAWRRCEERVAGENPALGAEEVRRAVQAAFEGASNSKVADLDILSYAGRVAAENPATELAQIFDDRADEYRQALSSSEPGALERQLTRASVATGTTLVDPSSAHLYDKQFAYDDSVSALKRLATSASTAPQRGLAADEEQGLLGSSAAVPADPIGTAMKLKRHWREYLIRIILLLSVLGLIGGLTASQILISKKDTADSGAPSSTVASVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBH4</accession>
    <name>A0A2S5BBH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2536560at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1363"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1407" mass="151300" checksum="CE8F771D6A6ABF2C" modified="2018-07-18" version="1">MSPSPGTSSRLESTHAVTTPNGALSGPNDSVGTDSDPRESELTETQGAARHSRSENRARSGDKVGGAAQSSEERRHTPSVRTNGAETPNGVTIDQDGGVAASWDAGEDRLEATQAIKTQPERNGLNGGQLSNGFQSSPASTSRDGDDGGGYFRSRLADRTPSTLAPLAETPSSPDLPSSASLSFDVAPTPTANGPFPDGSRTPTTSPRPAESSSSEPSGSRATSFDAPRPPAQNGHAWPVADRYVTSQHKGKGRAVPEHSSPLRGTEPDPLDPLSAMRLTPSASASAIASLSQSVSSRRLAQQRSGNRPSDPPLRPPDPPSPSSGSYSHPPSYPSNDSLYSSSPRASSRASGSTSRTRPDSHQPSLQQLLQEVDLGAALKLVQGLQSQQQLQSRLTSTVTSGTPANSATAAAGATVRPAAAPKGLDHPKGGELTNSSTVVDFGPLSNGGEIMEQDFRAEGHAVRSRIPEKPGPERRSSLMGGLQKRLRTTSSFGRSASIGQSGGSEIAGRLERFPSSNPTSPAGAKPRKRVEKPLTTEQARTLDEQISRVHLTLSPPTLQRAQNCAKYISLRYTPVFAALSANVPPPNPLDAARWRVRRQEEDKRARRVELARGAGARGRHGRGPSLDFGEASTTGANRLSTLGSIKAGMGPSPFGPRRNKHPKVWELYPDDLADYVASEGRTAADDRDMQDGGGEDWRRGKYVQIDVDSLFRHPTSSRWAPAAAPPILPQQRSPYMSASPPQMSPSSIADSVERDALMLPASSARSAAMSSQSSINEPRSRSPAASISHSLAAMASQRSFEGAPITRASKSAGVAFDGFPGSPLRRTTSLTAAVTGISQLRQRDPQRNDHAGTSPLDANKVDPVETSVDSPRNGFSRQLDRVRNRGLDDSRETSRSRTAEQFVSEHVLNSPTRRTASPLPVGSRTGTISDSSRRPSRATGRKHPVSVDLTRVGGFESDTMLRSSGDEASARGTGTRAGARAAWMRARRGILGGAWQNLKSTIDNYPDPNAPPSPRSRLGSAYFQNADLAALASQEKAGTMTCVVPAGHEEDDPFDSEDEYDRHPPREVVDLPEDDYTRLAGLAKQVRADATYLEETMQERVVTLNRFLHELVQHAESSAAEMRTPSHVTSPRLPAAVLADVAFVKEPASLAGVARPHYEEDAADDSDVSSSPNSSESDDDWSTSSSSSSDFPRRKVPNTRRNSSQVATSARRAPRRRESEVGMRVQTLNSHDSPAKVRGGRPRSHTLAVPTAAVRSLRRPTISQAPTDLRQHRDEMRSAEPLVVLGRSLRDLQAAADELDRDAAVVVCKQEGVDARINEVLARVNEVQQKIDREDFQRLRVLEDHYFRLRTALSRPSTSLDFLWTGLSYVLIILFWLSWLVVTVFRTIRSVVLFPFTALRWLLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBH7</accession>
    <name>A0A2S5BBH7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAM32A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBH7"/>
    <dbReference type="STRING" id="741276.A0A2S5BBH7"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12424" checksum="599D1F2E08123E7F" modified="2018-07-18" version="1">MPASDYQHRPGGSLKLKGGEETKKKKKSKSSSAQKARDEREGSAGASSSKLSVAHPYKTDAERRFEEVQRKRLLEKAAKQARKSHKDRVAEFNEKLENMSEHYDVPKVGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBL9</accession>
    <name>A0A2S5BBL9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBL9"/>
    <dbReference type="STRING" id="741276.A0A2S5BBL9"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26978" checksum="21B27FEF475CF4AD" modified="2018-07-18" version="1">MTVVHQLVLHPAITATLKVGSTTVGRDKLYRAIQYYARFLAYYCLRKGYSKETVARLQALKSTLALSRKLMRVGKPFEHLQAAVKGLDLTDPVLKFTTVGRQLGYAGYLINDTLVWLHTAKVRPFSAPTIATIQQRAARLWFTGIAFSLVSSLYKLYGLQQRQQAVSRAQGLSEKGEKSADLRLIQTQQAAVRYQLTQDALDILLPAGTLGYHQLDDGIIGLIGTVTSIMGLRSQVQKVLGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBT9</accession>
    <name>A0A2S5BBT9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBT9"/>
    <dbReference type="STRING" id="741276.A0A2S5BBT9"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43384" checksum="68C4EA387D39FA5C" modified="2018-07-18" version="1">MRASEHACHTAVRASGKLHQPDPPPHFRIHPTPTLITTYRRGLLAAPLAHSPCSEAQASPASMRRSALDHAANFILEQLAVRQQGPRSGDSARKGPLVVGLQGPQGSGKSYLASKLPGRLVELAQQADPPFPPPRAVAVSLDDLYLPWTNLKKVAENAPTNALLSGRGQAGTHDLDLGRRVLDQLKNPTPGSEVLIPVFDKSSHDGEGDRLDQSEWVRVEHADQVDVVLFEGWMNGFLPRTHFAPREDLLEVYRAAEQDPKGQRTNLGIDYDRPFILDYSLENLDRIQRELSQYEQLWKFIDVFVQLKPERLSYVWQWRLEQEHNMKAKNGGVGMTDAQVLDFVARYMPGYELWLPNITKGRNSWTMRGLSIEMNEAREAVSYSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC93</accession>
    <name>A0A2S5BC93_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2588</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC93"/>
    <dbReference type="STRING" id="741276.A0A2S5BC93"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="182"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="365"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="511" mass="54690" checksum="BA65C77708F4F4C7" modified="2018-07-18" version="1">MRTYPLSGQAFLSLSVRVPLTSLSCPTSITFPRLDVFATCTPCIRPRSASNKTQNSERTPLIGNNGSSSRQNGGAAERGAADSDRQHTYHIPNNHPRSPLLFTTDNDGSDPASHPVPSSTTKNTGRTGMDSATRSHWHGQEPPNFAQSMKNFILSGYINILLIAVPLSFASHFAGWGSTADFIISFIAIVPLASLLGDATEQCALKVGQTVGGLLNATFGNAVELIVGILALTRGELRIVQTSLLGSILSNLLLVLGCSFLVGGTRFKEQTFQMTAVQASSSLMVLGCATLVIPAAYRTSQLNGSLEKGTGGSLMGLAAELDSRKDITGLLKLSRGTAILRTHHYLFQDPNEEEEEEAKMNVYTAIGCLVAVTVVTSFCADYLVGAIDEFAQDFKIPKAFIGLILLPIVGNAAEHVTSVWMAAKGKMELTIGVAIGSSIQIAVGLIPALVIVGWIINQDLTLFFENFETIVLFVSVLLVDILVSDGRSHWLEGAQLIALYLVIALAFWFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCA2</accession>
    <name>A0A2S5BCA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCA2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCA2"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="195" mass="21281" checksum="AAAB1247D4351EFB" modified="2018-07-18" version="1">MPGKSLHRHLESRIALGRNTDSIAISHSDLRQVPDTQEVFMAADSDLSLIVEVLELVKEDGAADSLEKALKFHFSSLAHDNSALSSDISTFNLPSAAPHPLGPGLPTLLGPATLEGRQTVSKFNKPDSEADTVFIQLALWRIPDRDADVTLCVNWPVRSGETGEERDEAEARKVFEEAWRSFQINDFGLFAGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCC9</accession>
    <name>A0A2S5BCC9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCC9"/>
    <dbReference type="STRING" id="741276.A0A2S5BCC9"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="184" mass="19983" checksum="6646C741FD2CE48F" modified="2018-07-18" version="1">MKDLALDGGISPIAVTSLSRSSRLTALHSFDVTVSVKERDNAVRRRSPRLLEGTEPFFPPTAVLSPEVLDKFTVTSYLSPCQARQFRPAAAPFVHARWRSPEVIAAVSEAAGIDLVPVMDLELGHVNYQLGQKGKDGLRETPVMPSVQTRHFTGAELERLKALAEADTGEGPDNNVMLTLSFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCS2</accession>
    <name>A0A2S5BCS2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCS2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCS2"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015770841" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="343"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="663" mass="69460" checksum="5E1A01D9E64E3F86" modified="2018-07-18" version="1">MAPSRSSRRLRPSLAVAVLLSAAASSVAADAILEPRYNVFCSTPLDCVGSIAYLPPNGNYICTARKLCSWTCKSGYTAVGSQCQSQCQSDADCGSGTPAVSNSHNACVNGSCGWTCNSGFLATGGGCLATATSTAPAQTTPAASPPPSSTTPPIPTATASLPVRYGPVQCRSATDCQNVNAFIPTNGNYACSARGLCTFTCAAGFTSQGGQCQKNCVSDSDCTTGSLAQNSHLSCNSGVCGWSCNSGYFSTGGGCALQASTTSQTSTTSQAPTTTQAPTTTTTTTTTTTTTTTTTSTAPPVPTGTQCVINTDCNWSVPADSYNTCTLGFCTWACSTGYTIGFDGQGCVPISTPPVAAPTAPAATPVLTRTYAGSSFFDRWNYYDGADPTHGTVDYVDRNTANQNGLTYVTSSGTAILSADRTSQLAPGVGRASVRLTSTDMYDAGTLIIIDLKHVPYGCSVWPAFWTFNWPWPNYGEIDIYEGVNDRFFNQMTLHTTNGCTRSGDETGNTQWASPNCYAYSGGDNGCTVYDYDPSSYGAGFNAAGGGVFALQIAETGVSIWRWTRSQIPGDVQSGSPRPYSWGTPAGRWDGSTCDTRTFIKRQMLTFDITMCGDWAGLDSVFQRNDLSGACYPKYANCGAALQDPAAFSEAYFEVNYIKTFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCZ1</accession>
    <name>A0A2S5BCZ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 9">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2393</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCZ1"/>
    <dbReference type="STRING" id="741276.A0A2S5BCZ1"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="11">
        <location>
            <begin position="259"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="653"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="918"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="961"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="981"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109518" checksum="1E9EC44DD4737DB6" modified="2018-07-18" version="1">MSVKGGPRRGAPLPSRPTTALSTRTDATTGHSHQGEWILSILPARGQGTRQVGIVALEKNSARVTVTNLAGDSPTWVKSVHLARSKPPCVILLPSTALLASLPARKTLSEQETDSLAGEEDESTVPAADDPQVAMLVKALQAAFPEATFVPVIRKYWNEQSCLGSLPAPLYRALDTGYEYLTRLIVPPEDRLGILTACRNQYYSLSAASALFHWLEHAQGLAFAPRSLKIDYEVPDGTCLIDAESAANLELVANVLDKNSKQHLLGMLNHCFTPMGTRALRANILSPLTDRGKLDARLDAVEELVNSEERFRAIRKALEPLKGLDVDRLTSRLLAPPRRTASSRTGSSSSTRLAFFSQLGHAASNDPSLLVANHLASLLALRTFLNSLPALRASVAPSSSASGATLLGSIARALQDPQLDEIGEVVRENMNEEVWAAIGKGNKGKASGEGVMVTKHQRLFAIKAERKRLLDVARETYRENMSDINDLADAFRTRHALESLDHKQGEGMKGAAFFLRVNKDEWEEKKRELGKGGATNVVPKRNKVEFSTLDLMKLNARLAASEEEILLMSKDVLEEILDGIRDKIACLYRCSEAIALLDMLASFAEVASKNADYVRPEWTDTLAIKQGRHPLHEQFRMSEGSFVPNDTYANDATSFQIINGPNMSGKSTLLRQIALLHVMAQIGSFVPALYASFRPVAAILTRLSNDDNLEASLSTFASEMATMSFILGALKAHEDDKCLVIVDELGRGTSPDEGVGIAHAIAEEIIKAKAFCFFATHFKELSITLPGRFPNAVALHLETDIDRGKPDFSLTFKHRLRDGSTPLTHYGLELAKIVNLPPAMYERAELVSRTLASLAEEGKARAGETKLVRRRRALLELRTVLRDAADTAITDATKLRTILRELQQNTIRVLAETIDAESERARSRSTVTPREKLPEVVAAPFEADQPMQADPDASQDTDSFAQDATTADAEQAASGSASHDEEAEAEELGFGVADEDDMLEYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD60</accession>
    <name>A0A2S5BD60_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD60"/>
    <dbReference type="STRING" id="741276.A0A2S5BD60"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="511" mass="56760" checksum="8AB09B7CDEC02858" modified="2018-07-18" version="1">MEDDRPTAARVDQEEAEEDALPDWSRFAAFAKSNREKSEGAVLVPFIPKRGEKDFEPLAAADAFPPSSKEAKLSQHQRNLLQDSRNALYTALSSGSRHHSSKGHNSFTWRPDLDGGRAVCDSGNAAYGVHFSNIGHFNQKRKTLELLPEEAVYMVERGAIELWKDSGNGVRVPMSVQQAWSELLGHDEMTPERYQVYAFLRRLGYVVIRARPVTGAERIVTTKKLPLYRILINSALRPLVRLRDSVLRLASTLRSYLVGSHVQRIRYSVTRALRQGEGRLSGLLGGRGWASYDSMFAHLQIIPSGHDRPLPRGPLPHSPSTLTPLDKPVQSADEPSAVSQLPSLQEYPYQTFYHVYKPVTKYKKSDPPEPDFRLVIVNAATTPMPDLFEFSAMFDSTPMPPPPPPPGSGPSRPPRAQPNRPVRQDTTPSAPSPTRTQAVLASLPLIPRLFPSLVAPAAPARQIRKPTPYPRLKTGRRTILVAVVDNGTSSLLRFSETEFAKIPWIGTPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDN1</accession>
    <name>A0A2S5BDN1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDN1"/>
    <dbReference type="STRING" id="741276.A0A2S5BDN1"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="51786" checksum="EDA7F6FAE1974150" modified="2018-07-18" version="1">MVSYTFRTPGQTLGDFLRSLAVPRLFSSGSTSNADADAYEWAALRARQGGTSRLDFHDRGLRGPDGAVQILRAMERSPAVTSLILSHNPLGDDGLRELVVGMKRLRMRDIGGHLEELNLAACGLSDVSLHLIALHILRPSPHPPSIRELSLNNNDISLGSNSSLSSLPEFFGSTLSSPDNSLHALTLTSNSDLDARAFVALLDNLDLGTGPSHFTELRLSVTRLSPSCVDPLLAWLASRSGGARLQILAMNSCGLGKAGVRKIQTVIVSGQVRNLLHLELLANELESDEADSTAPPSSSPRGSASRDDEEDPQVFEGRVKEALQRNRTAWLETRKAALGIVAPARVLFGGDARDASAPDAESPRGTFPFFRLPVEVQVHILRCLLLITPSSVAHTYSEPTELRPPRLAALTEAQFLRVLAYCASSATLANEVRIGSTRGTMPSLNSNEGTKSWKTDGTGEDADSGWEEYFLRATGCDRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDW9</accession>
    <name>A0A2S5BDW9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_1934</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDW9"/>
    <dbReference type="STRING" id="741276.A0A2S5BDW9"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="536"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="769"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY74958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="808" mass="89344" checksum="9CE9E2B7EA91D6ED" modified="2018-07-18" version="1">MPTEAKETPFTLAKAAKGDKPVKKRETDSADAAEQSPRKKVKTDEQDVKPTDADKVDSKPSTSSSASTKPAASSFFAPRSSKPAESSKGKGKEKEELRNGSADEKDGKDEDGDEEMEEVKVKRAGKDASESPSGAGEEDEEEASDDEKEQEQEQEAAVKIADIFTKASKPDKAQTSWKAGEPVPYAALTATFSKIAATTKRLEISAYLTEFLVNVIDKTPEDLLKTVYLCINRLAPEYESIELGIGESLLMKAIGESCGRTLAQVKAEYKKIGDLGEVAFNSRTRQKTLFKSKPLTVRGVFDELKKVAKTSGKDSQGRKVGIIKALLAKCEGEETKFLIRSLEGKLRIGLAEKTVLVSLAHAAVTAEHYKADNKKSRGQLASQLEFGAEVVKAVFSEIPSYDLVVPALLEKGVDNLKEACSLTPGIPLKPMLAKPTKAISEVLDRFEGKQFTCEYKYDGERAQIHYLEDGSVRVFSRNSEDMTVKYPEFVTQLPRCIKEGTRSFVIDAEAVAWDTEEKRLLEFQKLSTRKRKDVKVEDVKVKVHLFAFDLLYLNGEPLLEKNLRERRVLLREHLQPVEGEFAFAQSEDASTVDGIQLFLDKSIKDGCEGLMVKMLEGEGSSYEPSRRSIHWLKLKKDYLQGVGDSFDLVVVGGDYGKGKRTNVYGAFHLACYDAESGTYQLICKIGTGFSDEALKQHYDTLKPLELAQKKAYYDVGTAKGPDVYFEPRVVWEVLAADLSLSPIYSAAKGLCGDRGISLRFPRFIRIRDDKDPESSTEPEQIAEAYRRQSIQSGGGKKGKGGTADDDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE13</accession>
    <name>A0A2S5BE13_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1967</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE13"/>
    <dbReference type="STRING" id="741276.A0A2S5BE13"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="16"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="570" mass="62857" checksum="52D0F9F4BE274A69" modified="2018-07-18" version="1">MGETVQGSSRRLVLAISCFASLGVFLFGYDQGVMSGVITGPYFKAYFHQPDRVELATMVAILEIGAFITSLLAGRVGDIFGRRATIFAGACIFTLGGLFQAFATGFRMMVFGRIISGFGVGFLSMCVPVYQSEISPAENRGKLACIEFTGNVSGYAFSVWLDYFCSFITSDFSWRLPLLMQSVIGAVLAIGTLFLPESPRWLLDTEQDEEGMGVLADLHGDGDPEDERAQEEFREIKEGVIAEREFGDRSYKAMWRRYRVLSCLPNSISYYAPLVFESAGWIGRDAILMTGVNALIYVMSTVPTWYLVDSLGRRPILLSGATIMAVALSLCGFFLWMDKGYTPVAVVSCVIVYNAAFGFSWGPIPWLYPAEILPNAFRVKGVSLSTASNWFSNYVVGEMTPINQEVLGWKMYPMHAGFCVLSFLLVFFTYPETRGMPLEEMARAADELFGDQPSGRGLSEVDAEHAPLRRSHSLPSFHRGLPHYHDATVEPPRIMPGSRHHRRTLSGHASLPGSGSEGIEAMQKWWKAGGKAGSRPTTPGLNSPRDYQAVQQSDEESALITSEDDAVRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE92</accession>
    <name>A0A2S5BE92_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A/B superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE92"/>
    <dbReference type="STRING" id="741276.A0A2S5BE92"/>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="219"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="584"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="928"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="956"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1039" mass="113541" checksum="D076D241789AE4E1" modified="2018-07-18" version="1">MLDQLAGRPSPSWRRSQVWLVLLFWLSRFYLSPSRGPRILWLRKLNRLLARKYTPWQIILATCTLFYAIRHGDVLLGLQAPEPLARLYSSDFYRATWIVTALDAGFATAMSIRWKWLRDIASLAFSGYYLLFANEADEKLRKFRAFCTVEMLRTTWEKQGNPYIRFFTRRDRARISIRKKLFLPRPKGSRYSKPLTLHLFFAGSQAELEASHELVMDIPGGGFICMNPMHHEERLLRWAIQTQKVVISFDYGKAPEYPYPFAIDEMYDAYTLLHETKGRCIGMNRSGVKSLKVLLTGDSAGANIAAAMFVKIFEMRSLAGTTPASSIADSLPLPIALNFAYPALSFHFTSWMPSSDLRVLRSESRSDIASLLLRQKDHLEHRSPLAVVEDIEPARSKRPKFTRRRTTSAGGSVGGGGWGSWGRSGALPGSKSFSTLTLGGRRGSLGGGGGGSTVEKDVREALEGHGAGDGSESSPDESDKALEDRVLWWDEDQLRSNRFATLDRAALKTQKELRDAVKEDEALVKGGGGDGTAQGGTKAVIVQPKEGGKEMLTETRLAMTSRTAFFNAGSAACGTRADGSDLSDRIISPSMARAMALLYVGPRNAPDLHSDYHLSPIFTPSHMLAQFPPVYMSCGERDPLVDDTVIFAGKLREAKEARKMEIQAREARHGDRLRMSSSGAKRDPLLDENEDDWVRMSIIAGWSHGYLQMVSLLPAAEKVIAMHAEWIVEAFEIAAAKEERASAQGTRTKASSLSSTRASPTPVSFPRTASDGPVAADDEQTFNVIPPTPVVPASATLAPSLPPSPQKDTLKVEDTSALSDGEDDEILTFTPKNRRASSNASRGSMGSGSPPVLPYNVSPPSLSPDPMEFNEPTTLPPSRDGQHGLPAHLVTSVERAMREQPSRRSYSIPGSTTSSRPQTPVRMNSNARATSSTSPNPSRTSRPERTLSLSPPPAPTTAASSARGRSPSGSGLPKPQGAIFIDARDLMRRRKEDVVFGIVSGAGSRTSSPPPRKSSHAGRAADGGEGDGGAQVDRRRTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEB7</accession>
    <name>A0A2S5BEB7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEB7"/>
    <dbReference type="STRING" id="741276.A0A2S5BEB7"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000057">
        <property type="entry name" value="Exportin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="991" mass="108997" checksum="7860A902734CF493" modified="2018-07-18" version="1">MAEQAALANVLLSTLSPDAGVRRQAERDLTQAQAHPSFGPLVLQLAQDANQQKPVRQSAALSFKNWIKANWALEDAPTPLSTQTAESLKQSIVAIMISLSGEPALQVQIGEAIAIMAEADFPDQWDNLIDQLTGQLTADNFVVNNAVLQTAHSIFRRWRSEFRTDTLFLEIKFVLDRFCEPYLNIFQQTDSILSSGTTLPPQQATLLHRTLLLLLQLYYDLNSQDLPEFFEDRLNQFMPLLLKYLDYAPAGAAPVDEDDEDEEVGDLEAAKAEICEIAQLYSLRYLDAFGEGGYLGPFVEKTWGLLTKLSPAVKYDTLVAKATAFLGTVVKMPSQRALFESQQTLEAFCEKIVLPNMTLRTFEEELFEDDPAEYVRRDLDTAGSETRRQAASDFNKALMEQFEAQITQIVTQYIGAYLQQYAANPQANWKSKDTAIFLLTSIATRGSTQLQGVTSTNALVDVIKFFSDHVLADLQAAPGAVHPVVQADAIKFLYTFRMQLTKEQLLSVLPLLIPHLQNPSFVIHTYAALTIERILFIKQDGAFMFGQDDIKESAEGILMALFKIIESGTSPQQVAANEHLMKSAMRVIVTARQSLAPRYAAVLRHLVAILGEISKNPSNPKFNHFTFESISALVRFVTAGDPSSLSAFETALFPPFQTILSQDISEFTPFVFQILSQLLELHPVASGLPDMYSAILPPLLTPTLWESRGNIPALVRLLRAFLGRGADQIVAANQVTPMLGIFQHLIQSKANDQHGFELLQALIESLPTSVMQPYMSSPIFVLLLTRLQGSKTDKFSQGFLKLIAFAAAIQKSDLTPDQVVAFVDGVQPGLFGQVLPVLLPEVQKVPMKDRKIVAVGLSNLLTKGSALLSEPNSTARRTPTLEALLKLFNSPLPLAKNTSAADADEIDVIDPEDVGYQASFSKLGASEKPRADPVAYVEDPRGYLAKGLEALGQTHAGKATVAQVPALMQGVAPELATPFAQYLRENGVQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEB8</accession>
    <name>A0A2S5BEB8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEB8"/>
    <dbReference type="STRING" id="741276.A0A2S5BEB8"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="312" mass="33928" checksum="621CC57B323EBA52" modified="2018-07-18" version="1">MSAVLSALPELPKLVEPAQTINGKRIRVAPRVNLGDITINNLGTVRKLHNVLFPVSYNSQFYAALNDDRLHHPEDYCKLVYYQDLPVGVIVCRLEEAEFAPPKNLGEASANHKAATEAAAAAAAAAANEDGETEKKKMKRKVHKYDDDKAYKLYVMTLGVLAPYRHQGLGSKLIHHVLSTAAASLAQPAPPATSTASPQANGTSPVASSSSSSKSKPDPKKKAASEADKGDSEQKKKDDAATEAEAADPLKPRIESVYLHVQVGNDDAKRFWEKWGFEVKETVPDYYRKISPRDAWLLERKITPSAASTDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BER9</accession>
    <name>A0A2S5BER9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BER9"/>
    <dbReference type="STRING" id="741276.A0A2S5BER9"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="450" mass="49625" checksum="DA9C932D93F97D73" modified="2018-07-18" version="1">MGPSGFSYDLQHCSSSSSGQRTDLLVRHGARSEGFLGHRLIELLVERYPQANIASLDIVQRHFPEKKQWTFYSADLTSLESLTAAFTQHGADVVFHTASPWTGSGEEVCEKVNVQGTKTIVEACVQNNVGRLVFTSSAGTVYDGIDLINVDERMPFPKHPIDAYNETKAKAEQIVLEANGKDGLLTVAIRPAGIFGPGDRQAVPGVMEVLKTGKTKFQVGSNENLFDWTYVDNVVHAHLLAAEKLADSVPLSVLDERQLPISLSVSRRQLPTSTFRPASLLEREQKLNPSFENVTEPDSPLPAIRNRYDPFANVNIEQACGERGVDREKETVAVAGQAYFVTNGEPIAFWDFPRAVWHEYNGHVAPWVLPLPAPVGLMIAGLAESVMKLMGKTPNMTQGKIVYSTVNRFYNIEKARRILGYEPIVGFEEGVKRAVAWYKANEASAQPTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEZ3</accession>
    <name>A0A2S5BEZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEZ3"/>
    <dbReference type="STRING" id="741276.A0A2S5BEZ3"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="92" mass="10083" checksum="6788E4EF847B57BF" modified="2018-07-18" version="1">MTKRTRKAGVTGKYGVRYGATLRKSIKKMEITQHATYTCTFCGKDAVKRTAVGIWHCKACKKTTAGGAWTVSTTAAATVRSTVRRLRELAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFB5</accession>
    <name>A0A2S5BFB5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFB5"/>
    <dbReference type="STRING" id="741276.A0A2S5BFB5"/>
    <dbReference type="OrthoDB" id="2532393at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13704">
        <property type="entry name" value="Glyco_tranf_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="107755" checksum="AABB79F7AE521001" modified="2018-07-18" version="1">MRHRSLVHACTGVCTAMDRDSAEARLLSPVATSPKMIEKDAEDKYGARNDASSPRIPPRHRRKASLPGLKPRLSTLVRLGRFAGTFIVLIMLVMAGAICRLAGGKEMSAPDHKPGPWTQAAMERLGWKSGSDLVSSTYLSSRFCSSSDPTVRRIEERLANPPLPPYRMLAGTMERNEGKDLLEWLLYHISLGIDHFVLYDHDSDDNTVEKLLPFVELGWVTLIPFKEDSRWAQPRAFERFRDEWKEHAKWLFFFDIDEFVVQNSTALEEAQRDQVDFVDWFDRRYSQYGGVSFGRMSFTTNGHYTRPADGAMASYTVSRVIDRNFRAPKIASQARFMQKGGGDIHKQVYTDDMQLVDSLEHGGDDRLMAGGDYPVYLNHYWSKSWDECVGRIKQKAFPGSWREQMGLKFCLTEMPGTAEYAAVQHVEAAQLARFAPSIRLAVERFEKRYPPVDYNSLSVSILSLSGRSTKREDIAASGDVEAGSTLVIDSRGPPLGELEVMLVSREWKHYLPTYAAAGGGQLFDVPSDLVAQSAELVVRRTYAASPPPVRDPVSPCSIMGHTANQPDRKQLLELQEGVCKGVEPTSAYNLATATWPHPRLRDRTLFRQTIHVLPSTRPQTLPSLATTAASAAGGWHLEPFTSQAGPPAGDTSTRRYTPERCPSRFDVQYWSVCGSTADLEAEGIYRWTPAGTTSYRDFVLSAPEVSLCLLRGEGEPKEKLRILVVGDSVASHTYMTLGCLLDQAVPDLRADDHVRFRSFQYEMFDLVNSNLTESDWLQIFAWSADGQREDADDLPDVVVLNVGLWATTWASLASYELGLRLTARYLRSIVARSRSEGPGLRIIWRETTAVSPQEGQDPLYQINPRVEAFNEVAKKVLLDPRRDVASSWSWLNNALHGGDSSHGPGQGHGQLDSAIEWLPAYVMTRSRADKARDNAHMCPVVQGDLAEVAMRAICRPQEFGAVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFF8</accession>
    <name>A0A2S5BFF8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFF8"/>
    <dbReference type="OrthoDB" id="2012053at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="5">
        <location>
            <begin position="225"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="563" mass="63185" checksum="332708D158EA4943" modified="2018-07-18" version="1" fragment="single">DGCNSSGASQFRASHARSRHSRRAACRPERRSSCRYGRGATASGNMLLFRRRGHRVGAMLYQRLSTSRYGWITLFGAALVLVLLAGYRPGSRTPSTLLVPQGTSLVKVDVALPSDYHNRSVRDFYQPFRDAAFAPWTCLDPNAPPSSRCKRPISAHTITALEYLASGGAYRIRYTGKDFLYRPLQVFGQTYRVLRLEWLLRRLREMADEGLLTRTVDGRQEPVRFDAVFRAGDSAQITKDTLSKDSGYLLFSLRSSPLHLDVPIPDPVAYGSNGNYVWPDRTTLVPWENKVDKVVFRGSASFSFGVDNWHSNNRFRAAQLSDAYPDLLDLGMTSMRVKPMPPLTGKSAESFFPLPTNDDIAAASGIRLAEPLSFYEQSRFKYVIDIDGGLGSSRRIPMMQTGCVPLFVDSNWFSTQDRLVVPWVHYVPIAEDLTDLVDKVRWLRDHDDHARAIVANAQAFVDAYLTEQAAKEQLAAMLERYSDLLAPDVKLDDSDVEVDFCKLNGARYVPRWFFPRACSGRAAIDSLMSSAAKRSSRDRWAALEGGRTLDVEEAVRRGACSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFH2</accession>
    <name>A0A2S5BFH2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-Fucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFH2"/>
    <dbReference type="STRING" id="741276.A0A2S5BFH2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57175" checksum="6DE86FB29BF2A32A" modified="2018-07-18" version="1">MYRLRNALSYQRAGPTAPTHGRAPLPPYDRLSEDREPPEDASAADFGRGIQQGNDVWRNWARGVAICVISLLFGILLARSDALRRYSACEDNFATEAGVWADYGQVGEVRVGTKPLKVLEPCKRTLLLQWSRYGNGLGSLVTAAMQTVLFAKDHDYDLLFSREANAYGAFLDSFTPHEPRRCRVTADMYNVGYDVQLHDVTSEAWRYRGPPRSAKDVDRLAVAEEDILLVNQWIRNNTYGNLSELESLPSTSAFAPIPAPATVPRLFRQRFLQYSAVAAEYFQLNPKVLAVRDTFKWTLGLEGPSKRPVIGVHFRGGDKITLECLQSPRLSWWAPLNLCCGLHSVLTCHVIYSGNITVHCIAALNALTTFAPSYPLFLSSTAKARLLLMSAEPNAPELFAADPLCARHFDVESFAHGGTRKPFEQPAFQAMRREDRLEDTHRFLAGIDILANWVDAAVVSANSNAGRLILVYGGSARVIKEQRIRSVDVPWHPLHWTPHAGYCDGTFKCFPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFJ3</accession>
    <name>A0A2S5BFJ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFJ3"/>
    <dbReference type="STRING" id="741276.A0A2S5BFJ3"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="87"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="292" mass="31340" checksum="FC4D661DAAA6AB5F" modified="2018-07-18" version="1">MAPTAQFIPAPALGGTTTSAPAGSHSHDHSHAHSHDHGAQEHGHTHELMEHPGKNHELMSSISRAGKFTERDMPNYSGRNWTERGFTIGIGGPVGSGKTALTLALCRYFRDTHNIAVVTNDIFTREDQEFLIRHEALSDKGRIRAIETGGCPHAAIREDISANLGALEELQAAYGCEMLFVESGGDNLAANYSRELADYIIYVMCAGFGVFPGEKIPRKGGPGVSQSDLLVINKTDLAVHVGASLEVMKRDADRMRDHGPTLFTCVKSGDGVEGVAELIQAAWTSATGGKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFJ9</accession>
    <name>A0A2S5BFJ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFJ9"/>
    <dbReference type="STRING" id="741276.A0A2S5BFJ9"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="149"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="264"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="517" mass="57932" checksum="9D5152B28FA3C10D" modified="2018-07-18" version="1">MAASVEARSPTPTGRQRPLSMHYGYSQPPASPTRTGSPNISHTLHSPQTPRRRPTVQGHRATSSLSSLAQLGIDLPPGRRDEVHSPRPLERSDWYGSTNGDPLSSQFRVQRSNSILTASPSLAAGQWGAFSGPQGPPSQSPAIGREHEDVQNRVLCKWLNARLEPNGYPPIVNLGTDFSDGTRLIQLVEVLTDSSLGRYNLHPYHRVQKMENAIKALDRIKEMGVHLTNIGPEDVVDGNRKLILGMIWSLVLRFSIADINEEGSHAKEGLLLWCQRKTAPYAEVDVKDFTTSWQDGLAFCALIHRHRPDLLDYDNMNKSPSAAAKNLAKAFSIAADHLGIPQLLDVEDVCGTRRPHERSIMTYVAQFFHAFSSRAQAETEARVINKFVDEMSELMLAVHDYERRVTELLEQIRARIRSIASSGPTPSSPYPDLLQRRSTLRAVPERRQWLMEKVATAQLLGNVRVKLRTYGLRGYEPPEGLTIEDVAVMWEAMRRAEAEQLRSIDAYIQRFVPKVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFN6</accession>
    <name>A0A2S5BFN6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFN6"/>
    <dbReference type="STRING" id="741276.A0A2S5BFN6"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="481" mass="52572" checksum="6152E0D99013B35A" modified="2018-07-18" version="1">MAWRSKTVQQSRWAETTQESSSFGATRSHAHSTTRPEASTISKTGLRKARPHIGKQVNELDLLLSPSRGLAAAGDPATPAAAAVEHLSLSDPEVQERFRTHIQDKLRKWATPARTRAASQRKEELGTILLDFRKLREGVTSSRRIDAFACEVYEASVLLSLYNTNEPQLSSSLPHLVSSLHPAASLDSQPSSTAPDGDPPDLTAPFEDLSLDPTTKTNKPSARAADPARRAYFLVLHYLHSSLLPSQSAPARADATAVPSLAGPTASSFLPTLASALAASRLEPLAASFPPSQTSHPNPHIAFLLGLRLALEQNNYAALSSDYLSIDKLPPTPPSVQSHLEALHLSSPSDPPSPSVSGLSTSSLGTFDPLAHLLQSFLARLRQNRIWPAVQRAYRFPPERTDWLGKVLLFEFEVEVEQREAGLEAPQRQTRSNRGEVQIKDDWDAEEGEEEEGARHPPRRRAIEEEAARRAAAWVAERTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFP3</accession>
    <name>A0A2S5BFP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFP3"/>
    <dbReference type="STRING" id="741276.A0A2S5BFP3"/>
    <dbReference type="OrthoDB" id="3366659at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="322" mass="34815" checksum="543F825850CE14F2" modified="2018-07-18" version="1">MAAMKAQSDPPQSLLDHTLRTAPLRVVYFSIAATGLGAAAGAASGVARNQPAIPTSFQASIKTGIFAFTFFSIREYGAIPLLTHFSLNPSPVPPPAHAATPAQPPSPHTHNLLPTAVSGLIAGSAFSYFQRPPATPLGTHTRAGVTLALGCTVLQGIVNELDVVRIRLLMWGEERRRIKRIEAGMTEPGGDELPLAGSTAPALASSPLPSRSSASSNQDTSPLSDLTHVDPRHPSTFSDPGRETFSERSDRLASSGWSWFTDKLSVLAPLKRIDEDEYERRLDELLKLRTGERDQVKTEIRDLEVVKKRLEERQREADASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG81</accession>
    <name>A0A2S5BG81_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG81"/>
    <dbReference type="STRING" id="741276.A0A2S5BG81"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="446" mass="50336" checksum="51A6862CD57F5D47" modified="2018-07-18" version="1">MASRVAPFRRLLRPTIWHNNLAPRLPVPSTSSATATWSSHAPLYAKQPPPPRIQATWDDSGDGGTDLFAVNETGSTSSSLHASSEGHGRSSSRDRPPHLKSAARSSPPPPTHIDPTQLPLGSIPKPQKQVKFRPANKFGRPNRRRNKAPPPPPLPAVEPLPNVADLDPVHLSELRLWTLRRSGITPTDKDLQRNLSAWLIGAHKAKARAEHEEKRSRELRATKRDALDLSWEWDRQVAVKSGVERTDREKRRDGIVLRRLERRRLEKLQAAQDREQEKRAELDELIRRREDEARAKVDAAEREAEQKRQADEDEAKERLRNAPDWKKHQVALREQFPDGWAPPKRLSREAMDLIRTMHAANPTQYSTAALADQFKVSPEAVRRILKSRFQLSKAEADRREAKRKEARKLEVAQGSSVWGGNVAAEAREMDSIRSGCGPEGDASRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGF8</accession>
    <name>A0A2S5BGF8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGF8"/>
    <dbReference type="STRING" id="741276.A0A2S5BGF8"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF72">
        <property type="entry name" value="CAMK PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="359" mass="39680" checksum="E612D5EE0B667656" modified="2018-07-18" version="1">MGFAAFPSTYETLSPFLHERFVLLEEIGVGGSGFVLKVQRRQDERIFAAKLIARERIARSALIRTSRWGSVPPGFEAEADGTLVVPVEAWAMRRVAHPNVCSFEELFADETFYYLIMEHHGTSWQTSPSLPISLPPTPPITPPGNYLDLSPSAAQSAPSFLAPRAPCQAPPLLRRSSSDLFEAVERHRHFSEHLARHIFRQIVAAVCDLARAGILHRDVKDENITLAEDTLQVKLVDFGSCVLFNPQGPPPMQAGRRFYGTWTYAAPEVFTGEAYEMFPAEIWSLGVLLHVLLTGENPFTSAADARQGRRMQGKVELSAVASDLIDRCLTVDSRQRISLAELASHSWVSGMQWAGAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGH4</accession>
    <name>A0A2S5BGH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGH4"/>
    <dbReference type="STRING" id="741276.A0A2S5BGH4"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="981" mass="107873" checksum="CC5606AAE5BDD5F6" modified="2018-07-18" version="1">MASRHTTPLANLTQLLSEHHETLSNLYEALSPTPQPLIEAPMAELRDSLSSTIAKQVAHAQAEVAAAEQQLSIGWRRVHDWQAALGEPIRPAKKRGDGPLQSLVEEVDRIKEGMKGRMQERGKRILALQERLRGLAQVVGREYLEVSLEPAAEEGRWEDLDLTHDRMSALEREAQRCEAEIAHRKELLNSDASEVFALRCELGLYIEAEDTGAPTGDSTDEEILWHLGIGEARKERREMQPTADNVRKLEEKRRQLEDEKDSRNETIQTTYDKLYPLWSLLGVTEEEMDDFVNRHMGSTLDVVTAYQTELARMLALKRTNMSAFIQRERETMTELWDRLYTSYPQRLVEFPSYSISVEPTKVWNPALGRDEDVVSDNVSEELLLAHERERERLEREVADAGPMLDKLQRYFGIVDLKKQLEAAAADPSRLTDKSRGAAARLAQEAKDRNRVDREKPKLEAELRRLIPQWEAQHGRPFLVNGVSFIEGLDEQIRAEEQEKENRKRAKLGASVSAGAARPLRAQHTGAAAAPLKRQMTGASARSATSATSTDPPAAKRFATGAAAPTPLTGRIVRPKSALGDANGVPPLQYGNVPGSVAKPLRAQMTGLARPRAGTVSAAVAQTPLPGGRIAPTNSSLMTSVGPGMRLPSGWGAGAIDSPTLALAGAGAGSAVSATLKKAGKAAQAYEEDEFVEDEFEDDVDSVVVGEELSDAPRRGLQGQDKRAAIYEKALGDALKAVSKPTRELKRRPAPEAILASLVQSAGPQDLPRVVEVLQQWRQKELPAPRQATVQHLLKRFAESDRPQDGVNVLAQRDKYRTDVPADLQATYPLFHALSKPAATPAPAPADSAAPADEATEAAPPAVATPPSSASDSAFVLYDLLQLYHPGIASQDSFVLLTTLAAALRNGESTSERVHSVMKQLQALGEDQVVQQVRRDLSKRWQATMRMRARAIAYAMRDLDHAEFEWFAHLSETLQKLAVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGI5</accession>
    <name>A0A2S5BGI5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Restriction endonuclease type IV Mrr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGI5"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="24772" checksum="8E56907F0CDADD8D" modified="2018-07-18" version="1">MTTRATTARRSATTALRASARSPLPSIAAVRPSTTALGTAYELATSRTLARLPFSIARLVNVGGAGDGGVDLRGRWTWSVDPTAPPPRGLLHLPNGAAPSATESARGQEGQGRTTWDVLVQCKAEKSAVGPSPVRELEGSVLAELARTRRRSPTLSIVSNSGQSDGPAPHLIGILVAMNGFSAAALAHAQTSTIPLVMVHLAVGDVAEMVRARGKHGALLLRSASINKALRNLVTSAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGS4</accession>
    <name>A0A2S5BGS4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar pre-ribosomal-associated protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BGS4"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="1">
        <location>
            <begin position="68"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="2">
        <location>
            <begin position="1569"/>
            <end position="1764"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1924" mass="206488" checksum="35DE48AC1D7EF00C" modified="2018-07-18" version="1">MEGQAGPSRSAKPQQALGEPFDSAYAVEQSLQTPLTQIDKRAVALVEKDSPRAQSDLLLDYVRQNPGCNGVFAAWELANKTNNSPLSAAALSCLTSLVRLASTDPFTSSPEIVKSLFSAQYAPYFERSLNPGRNDVTTAVLKLCNVLVGFAGGKYARKVFGCFGWSPKVTSRLYKTRLRSLTSFNALAKPDIRTLLVLLVVSFLSAGDVRLKTQVLETKGLLSGVFKGLNEDAEVVVNLVLETVGRELVVERRVALDARRNLFDEACINEPVGSKCSPVLSTQLVKLYDYPLPVGDVEMPASHPSLSVHRFFRLIAAWLADQIATSPVGRSSGPQRVLATLLRALKVTEDSIQRELGLEILRSAPVLAGAFWLKFPSSLDPRLSSRWVSAITFATQVVGLPVPATLSIPANAANALLYAPPSVSSILDTILPPPTSSTLNRTWYTKALTHEVPLVSFLSSLFVLSILQKASTTLETMAETSRLLEETASGRWAIQVRKVREELKLRLPDPAIVVGLMTKTAAAASGEAAPSSASSKKKAKAVEAKEEDVAAVEPAAASTVPAGSEGALLRTNVALRILFLYHRVCPQLIATLKFDFAKLPQTYARRPTSAAPAQASVADQGEEGIRAISSAYALRLAAAHSTSSSIMSFNRPGDHFKQSLVPLFQLYRTPSTPSSRSLLREILKRQLDTPLLFGTSSAEEIEVWLRALPVPTIDSDEVEAVLSFFESTVQKTLTSPLKASEVNGTEVQPILSPLMQNVIAALPTALKGDDEERVERILAFYRDVVLHLVAQQQTLDAARQAVEALHSVAEPSPAAGLTSRLLNDCIRKLTAADAAVEAREGLEGTLATLVTDGDSEALSDFVGNLSPLRENVFAAVEPMSDTSTQLLQSTIRAMPLPLILLHARETDLQSAPIRAALLDVIEAQGSPLLAVQVLLHRLLAGYSSALASFAGDVATTTKDKSMRADIAGRVTGKQGLLAGFAAADAPVAAYEGMLTLLSTVLDPTVEQHRQLAQPFCELVLADLNSAEIDEAPKKKRKQRVSGAGTQPTLSPRVLAAGPLLPFFDAAKSLPLLDALITHLAPSEPDDNTQKILSSALEGILALPPTDAFIAFWSSQLLRLLALNQDKNVDAAGRILIKGARAIMPLEDISRDEAAPWRSQAASWTQSLLTSAAIGTAEATTLAALVHRSSDARSYLASWLDAHADDADLDALALVPVLTALLDVTVARGDASNLPSGLVVRLVKQALETKTFNEQAAQCLTASLRSSPGAESVIAATLDEAAVACASISDFRHLLPITASCAQVSAAARPVLAKIANSSFGLLTRALVEEGEDDEDTLALVTSLTETIRERTDLRLDGAALDVLLTAIATSRGDRPYAVQLATLLCERHALKDNEVTRHLNELYASAAFLILAGNPSSADAAVVSATLDFALALAARSPASAASARSVEHLLPFYRGTLASRDRSLLDMFQRVELMSPASIAPGLSAWVPTSEPDISLDGSRIGAIGAADKKAIRRSWAVAFSSSASTLPAEEAQRTYDPIFLVNYVAALLEEDDMKPQDWTTLLESGILGTCVAALAASPIALRGMARAALASLAQRIKPLTFREKDELELVLTQIRLSIYSQAGEPLPASIALFLAHCAALIGAPESPLYPTFTRFLLQRSTVDARDVPMFYSMLYSSNADEFAASPRDERLWMVRFLTEGLVRSQDWKIYRRRQVFELVASLFSSTRQDPQMRKAVLKLLEKATRVPTAARELLSRNGLLGWLAAQAWQDDVERQLALDVVLNVLAALPWDKLPGVADAVEAVEVAVGKEAAQLDAATLLAIIRTITSHLAPPHGVSSTASLPPLLPSILSRLTALVEPIVVAGPVLGEQFYATATLLAFVRSEAGLAETTRDRHVWRAALRAGLDAGVRELQREVMRLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH05</accession>
    <name>A0A2S5BH05_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH05"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015565302" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="15570" checksum="99165EDFC6FB4A0F" modified="2018-07-18" version="1">MLLLRLALCIAAVACAFCAPLSVLREPNSASNDLDTFVSGLDSEDSGSVLLGSGFANGLSSLLRTGVDETVGAGLAGVGPPRLPATRVTLNFGISVDVGELPEASENGLPSSMSSSLLTGDASDRSFAPFSVGNVGAAVAEAGASASTTPVNAISLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH57</accession>
    <name>A0A2S5BH57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH57"/>
    <dbReference type="STRING" id="741276.A0A2S5BH57"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="356" mass="39139" checksum="8094FE00B8646613" modified="2018-07-18" version="1">MDSPLDGLEDVRGHVIIVRRPTPADVSVANTDLLRRWQMDGMGIINPTEQYGYVPSLSYGIIFVVLYSISTLLQLGETVYARRYWWMLSAVCGGILEIIGWAARIYAHGHPLNYTAYVMQIYCLIIAPTFYSAALYFGGGVAIAHVAPREAWIPTRWSKCGFLAADVISLVIQAVGGGIAGGAVGEPNNGAQIKRGSNIMLAGIVFQLAVMVFYVVYHVAWAIRARREIKLAGGRLQLMLLGLLLASAGIIARGSYRTPELAEGFDGWIATRQSWMLFDGIPISFAAFTLNVFHPAWFMRFSSEIEARNAQVSRYALDREATLVAEPAQYRDSLETMVEEPSHDPAPKQNGSCSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHA5</accession>
    <name>A0A2S5BHA5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHA5"/>
    <dbReference type="STRING" id="741276.A0A2S5BHA5"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="136" mass="15573" checksum="654A3A4C2C2AAB4B" modified="2018-07-18" version="1">MPAGVPEVPELGVTSAPLKSASFFIGEHCKAFNEDFMLCKAENRDPAHCLKEGRKVTRCAQDLIAKVRSTCLQEFDRHWQCLERNNQELYHCRKEERVLNSCVFEKLKLKKDIPGSPEGQPQIHEKSWTVYGAIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHJ4</accession>
    <name>A0A2S5BHJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHJ4"/>
    <dbReference type="STRING" id="741276.A0A2S5BHJ4"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="518" mass="57445" checksum="47C8FD36EFAD5ADB" modified="2018-07-18" version="1">MSASAGHSSPARSRHVVWLWLGIVTTAFVSCSSLAWLWTAPRSLDLAQANQSRLAAWTAVLGSSLHGHGQDDDPLAYRRAVHLATTPAHHLQHSRTLTFDHIYVLSLPARQDRRDDMAKLAQALGIDLTFVDAADKHEPFLQWIAERVRESKDLRVKVMAEARGVAPSQIGGMSIGSDWVTPFPGPLNSSDPTRFPRYPRANPRLHYQGDNWVSHLEALHSAGGRHTALRPFTRRRGGKPKPHGTPSRGGSKGGALNVTQLLWDPLERQHVRQVHEGVISTYWGQTRAIKRMLENGDRTALILEDDVDVEWDLERLWNAVERRLPTKAHDEGGDNEAEWDVTYLGHCWGGEYQQPQYLNPLLHRSTGPMCLHAYALSAAGARRMLDTMLDPWSAYSTAVDLVVPSLLHIQSALDALAKREQKATLSSSGLEDPSASAAAAARRPRLINSFSVVPPLVVQRKDGPSDLQSGTGSKWRGLLRDSTVERIKRDEGSWTAEWEDRYDEATPDPATVVRCGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHL6</accession>
    <name>A0A2S5BHL6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0461</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BHL6"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00075">
        <property type="entry name" value="HATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000006">
        <property type="entry name" value="Sensor histidine kinase WalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000045">
        <property type="entry name" value="Two-component system sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547:SF2">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="1322"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="1673"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="1932"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1270"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1876"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1580"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="843"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1282"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1897"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1918"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1370"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2073" mass="224035" checksum="F2284EB10CE2C036" modified="2018-07-18" version="1">MDPTSRGVTALAQLPLVSYLSASPSPSLVLALSPLVDYLVAQPLATLARPPPVQTPLWDGKAAQLSTPPPASKPRLPVLNRRDAAGSDAPDADQAMSPAEDIRGLVEQLNVQTPLSGPGPQSSRQAFADYFSLTSTAPAPTSADGAFDEASSELAEQASPAALSSTSSASSAATIMSFASAGTAGAAAASESLGKATPPTPVDDVDTFASHLVGGSKGLDFAAPNDVEERLADALRPVYRNEAWRSIEARRAVRPGPGTRETSNSTLKAYRPALYRAQSSSSREKRGRKSLNRRGSATEEDLLIDSLPAAPGFETKPKGLGTVEEEELEPDDDRPGDLSMETDDDDRFPSASASENPDGDLDAEVQALRFLSAEEQQQLLVFLLELVVDMDVLGETGTVTPDIRSPDASPRVGGSGYGSPRSSLRQLHGNEQGSRRGSAASKGGPPRPVQHCKIGDTDFTATIIVAPVPATPQSDLRAVERSLPTGWVILTTPIPPVPAPTPREPGLPQAWPRGTGIGVPTRPAAPASGSSSSLTAVPLAPAGSLAHSYQSPTAETIRTAGPASHPSVREGDLTPSGESSLDADAKWMASLGDGEMAQRIRAHDWSRTTLGPISSWCPELRTVVASILASPFRECILWGEDMTIVYNDLYIGTAGNKHPGLLGLPASEGWKEIWDGLNSVAQKTLAGETCFFKDHFLAMERLGFVEETYHTFSYTPFRSASGKVLGILNLSIESTATVIAARRLATVRDLVQTTSLARTVEDFADTALRSLSSNPFDLPFVLLYTVEEISNKPTKREVRAGYQSSTRKTVKLTCRGATGVPEDHPFYVREATVDLASPMSRHSSSSASASTGTGSTATAMDLRGFQGASSASNGSGASTAGPFAIDEDDEQSWSWPFEEACLKRDPVLVEDLGNLAETLDQSRGWTYPVRQASVIPIMVEAGQTVPSAVLVLGVNAMSRYDHLLETFNNLVARHVAIGLFAVLAAEQDRARADELVKLDRAKSNFFSSVSHELRTPLTLILGPLEDILTGPEKDKLDRQQRDKLVIVNRHANRLLAMVNKLLDFSSIEGGRMNFKYRPVRVGPLARDIAVLFRDSIERSNIEYTVDCDDDPADSLPVYLSPDLLEKVIFNLVGNALKYSKPGKGTIAVRLQSSRAEAVLTVSDTGIGIPQAELSKIFDRFHRVESSRMATGTGIGLALTLELVKMVGGQLEVESEVGKGSKFIVRLQRGHTHLPIESVDHTPEDTTITQQFQSRSLTVVDEASSWRYDSGVETSAIEPNPSPSENGSSMSMAEVSDPGNSSSSGNGDDFVNGAEVLSLKNRTVVLVDDSRDLRTYMSSLLSKHFRVVEFGDPRQALEYINRTPPDLVLTDAMMPHISGQQLTTTLRRNPSTALIPIIMVSAQAGTEARAEALEGGVDDYLVKPFQGRELLARSRVHLQLGLMRSELSRRVDERTRALIDSDARNCALAERYSMLSTVSPVGVIEIDTHGEIIYANPRWYSITGLGDGPLAEWLDCVVPEDVKKIENIWRLATSGGEASDASDRQFRFKNGRVAMLEIRASSEEGVPNGYVGALTDITRQKEIELLHLREVERRAADAEENRKQTEAFLVTNSGTLWQNAEVVAASLGKYVKALESLQRGEYVDNVTLASLHDEMLENVDAVESIILCAAHQGRIADDILNVSKLNMGLLTVNPVSFELVPRMHEVVKISEAECVQKGIDLRLEADESIHRLNASWVRADPSRLHQVLLNFLGNSLKFTSDSRERRVVVRICAHEIQPPIRPQAMRVSQPPPNTLQDSIWITIAVEDTGRGLSDDELKRLFARFAQANPRSDQYGGSGLGLYVSRKLVELHSGFIEVESQLGLGSTFSFTIPCERAMPTDQPLPPPLAIPMRIPKRPLSTSPSETSKASKTPKSTPEAAPSPAPPAKPDLPVHVLVVEDNEINRKVLNRQLKNAGYQVSMACDGQQALDALAEDARRAVQDAAYNGVQVVLMDIEMPVLDGLSAIRELRRREQAGEMNRRYPVCAVTGNARDAQQAECLAAGFNDVATKPYKFNEIVAKITALIPPPTMVLTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHN3</accession>
    <name>A0A2S5BHN3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHN3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="476" mass="52966" checksum="37F5A391A15EC82C" modified="2018-07-18" version="1">MTAPPTQTSLLSLPDELLETIVQCVLTERPKRPAALALTCRRLGRLVRHQIFRRIHYEGSARRGRDSLLQQAFEVCPSARNLVRDLLYLPQYNFSTGASVLVSDPELPYIFFIFPAIRTLDLAFTRSDGLTSFLTGPTTPNDGSLRHLEISYEFEREEENACMRRAGWWNPLLRFSDLLGLAVVVEPGGEDSGVVAFETARLLPLESVRKFTISALMFPTNGLPLSALLPSLEDLTVIMARCDDEADPCTRLIRTAPSSLAKLTIVTYSIASPWTAGFVEALTDRPTLRHLSLTCVAIDTYRASQYFSSSSLRALTFTSACPSDDVDLLRLVSGRTRMKSLEVLRFDYFRPSGRQGIRYSLADMLASTGPVDLASALESLRSHEGPRWPQGCTAAGLQRVVEEAQLHGIRVCGMAVESLDWVALFDDEVERYLVLRAVEKGDRSLIDEYFGRDKADEAIERHSWRFASASAAAMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHW1</accession>
    <name>A0A2S5BHW1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHW1"/>
    <dbReference type="STRING" id="741276.A0A2S5BHW1"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="408" mass="44625" checksum="8CFBB393109358DA" modified="2018-07-18" version="1">MQANYGTARMAVPAPPAGLPGHQMNGAGQPGGIEDSESEEHRRKPRVLLMGPRSGGKSSIRKVVFEGMAPSDTLFIEKTNKSSPDDLNSFLSMRMWDLPGGQLDPEQLNLSFEDTDAVIFVLDAQSTLHDVIRKLSVTMHKAYTANPGIQFEIFLHKVDGMSEDYRLDTLQNLRDRLTEELFDMSPELESNMNVFYHLTSVFDTSIYEALSKVIQKLIPEQAMLERLLDLLCQQCSMDKAFLFETASKIYIATDSAPLDNQTYVVCADYLDLVGDFSQLYETSEARTPAGEGSLSRSSTLTRGQREGAATASARRDSSATPSVPPSPAVSSATAIAKNKAPRRLPHSKVTLATGATIAQWTINDTLSLVALLRPHAQDQHAALIDYNIATFRQAVIAIFDVGVSAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI09</accession>
    <name>A0A2S5BI09_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="38"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="499"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="612"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="688"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="709"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
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        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1085" mass="116335" checksum="DC628D78416A8525" modified="2018-07-18" version="1">MRRRSSIALPNFGSRRGSNASAASSNIKDEIVKDIFHVGLVNLGNSCFYNTIVQSLSATQPLADIITEAPESSPALRKLSPSSTDYNPDLDALPSPLPMTAALLVLLDKLDPTAKSDLAGAMGKKAFNPKSLLRQLSLKHDEYAEATQQDSHECLRHLIDGVMMEEQDLIKKILETVPDNHSHRPSMHARNSTVRPSHGPDAGLPTNSAASPVTPTPEEPRAVATFDDESGNESDESSSGSSSSSSSSSSSDDELSESEVDERRLTLRQRKKRTLRPFVGSIFEGKLASFIICDECKNVSLTKEDFMDLSLSLRDDTGNKMRKASRLSPYRFFGRKSSKASSGEDSKGSSASSLKQAPNGVSRERLSQSETEGSASPSEADETDEDHIRPAGLRPRGDLDGNAVSSHRSRVSSLDPSRSSREDARTHANSLPVPGHSSHERDPSPLGRAISVLSQNSHGEGHGHGHHLFHRRPKIPKPTSEQVAYIKKVLVDIPGPVSANAPPAGLRVARPPGSRPSSSGTDAGATSDSVSSTASALTQLNIGSATAAPTVSWQDTDLFECFRQFTSVEVLEGENSFACQNCWKWLNPELEAKRKADKARRRAERIERRRVRRAIRRGEDPHAAAAPDGNDLTSDDERDPAADRTARNTPSHSPRLGSTFTPLSTVPPIEPLGASAVVAPTLVAEPAPLTNGSDEAHAPANGTPMRHLSVSSVATSASQAPTVSTDYEGGVSSEVFETTTDEGEGDDGFDEADDSEPSPGLDDGASLSGSLSALPASRSNDPKQGKPIDRTISEAVSESLQAQIKPLPPPSQGPVKVAGKATNGHAVPSKPPPRKQRHILRRAHKRYLISPADLPPVLVVHLKRFMQTSKSSLFGSAFVNLKKRDDPVSFPKEMDLTPFLAPSGKPPRLNPNAFGSTASSMIDEDARMRASAHSGHKVELEKEVHNARYRLYAAVVHFGDLNTGHYASYVLSNRYGKGENAGRGERRWVFCSDEDVAAVSEAEVLRSRPYMLFYERVEDKTGRVSNSLIPSNTADVDVVPVGGAAAQGQGQGSPAPAAVQVLGPDVARTAEPVSVQDRVPATVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BII8</accession>
    <name>A0A2S5BII8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BII8"/>
    <dbReference type="OrthoDB" id="2349883at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="516" mass="56705" checksum="DA7C94F90FCAA49A" modified="2018-07-18" version="1">MKSRVPRSQRRRCLRAFSAAAISDMSLRISRRLATGSTGGWPACPARRLVVALPAVRQSRLRLPAPTRSFSATTERYAVTKLQTSLPVEIVERLEAGKLAHGGTDPNQKIQTVPFVQAPEQAYELSEMAATTLFGLPHVLRLGAHRILSSWFGYTALKPTAIRSIAFSPVLLPVWMVDVVVKGKALLGDVQVDLDVASTASPIPGFHLPPLSQLNVSPPINNADLVSFSPAEHLTQHGQSVTQIPFSRHPLNLLKKLSSMPRRIARDEDDVSFDPKQFKETLYAAYPLYVPLYLGEWAMAEGGQEKRVTTAAFAGSYGPAFAIYPSFRATESPEAVTWLPDSDSLSLTISGRPSHSAAAVVQDPETMSSMKELSPRLLRVIDEIKEERSNRAIEEGALGDLWADVTDVIEGGDEAVRELCRSEDRVMAFGDWHDINTAYIEALSGLELAQANLEALRELPAFSGLVITPTGVRRSTLEEMVAELEGAVSKWKELLDEHTPEWIRRVEAKRKGSARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIL6</accession>
    <name>A0A2S5BIL6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIL6"/>
    <dbReference type="STRING" id="741276.A0A2S5BIL6"/>
    <dbReference type="OrthoDB" id="2524921at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="87077" checksum="CC8242B987D5A8C1" modified="2018-07-18" version="1">MVVTRKKYPVVEPPLVRREPTRRAAAAKSKKNQSTTATATRARPNLAPRKTAPRPPSERATTAEADIEDESDDDDDDDESERTPKAKRVDLTATEVESNDDEAVDSDAGNKATAARPASAIKGSETERVSDTEENGSSSSTSDGDSAVVANLLTPQSKKRKNAQAQEDRRRKRQGTVIAETDHELPASRLLGSSRSPEKNPRVYGRKGRVDKGKGKAVESEASDSEDGQPQTGPRQGTDDQDDRDDQDLGTLTVSPRRLTAGSSRARGARPGRAGQSESPLRARPSKSPKSPAQTTASRSQKHGPTRTQRSRDSAESSPANARQPTPRQRTPAAMTPTPAEESDADRILDEDDDEWNEGKATHPPQIFVHANQLARRDGDDDSLWQPDRIWVHEQFVNADKRDEICKFIESHGGEIVDKLKKAEIAVMPPWHATGYEEVFNRVMSKGVFPVAYAWLVESAERSIKEGRPVRLSRLSYAAPRPRRADNRSKRHLRMSVPEKEQFARSYAAWLREEISRNEMLEQMHLKFFDGTRRTTIDGFDAILTEHEKEIRSLARRVNTSRVRGLSEDEEDGGFTTDAGDDAYDDFRRSRNRSRPPLSDSAPRNQLASTTQSNVVDFLTRLSLAYGKSEALISSIFLACGFDTDWTERVLQIVKDFELRVADLMPDEPDYLDAAEATRAEILDQEELLWNPKVDARIRRSKDAALDDIAAELGLDIDEVRERKLHLQRTAQKGIRGWYPDEEGFRRLRDEAIEDVAGMDGDGEGLASLADSDDLEELTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIM1</accession>
    <name>A0A2S5BIM1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BMF94_0200</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIM1"/>
    <dbReference type="STRING" id="741276.A0A2S5BIM1"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="20">
        <location>
            <begin position="46"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="21">
        <location>
            <begin position="185"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="POY76610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="979" mass="105193" checksum="340EED244B19C861" modified="2018-07-18" version="1" fragment="single">RGKTRRLISFFSRLTPTRQPAVSFISQRSGSPRTTVNHSTIPYARATISDLRQGIAARIAEHKQKFPRFEPHLAILQQGARSDSSTYIKMKLKAAAEAGIKTTLVQLGTAADGVGEQDVMAEVERLNADANVHGIIVQLPLSDDIGREGERRITEAVSPEKDVDGFHAYNIGLLSSRASEPLFAPCTPAGVMLLLESTGVDIAGKHAVVLGRSDIVGSPVCALLRRKNATVTQCHSQTQNLEQLVKQADIVVAAIGQPRCVQGSWLKQGAIVIDVGTNYVDDATRKSGSRLVGDVDFDSAREVASYITPVPGGVGPMTVAMLMENTVLSAQRLFEKSQQRLVKPLKLVCKENVPSDIEIAKSQNPKPIDVLAAEIGIPGQDLEMYGRNKAKVKLEVLDSLAHRRNGKYIVVAGITPTPLGEGKSTTTLGLAQALGAHLGKAAYACVRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNLHLTGDIHATTAANNLLAAAISARYFHESTQTDKALFNRLCPPKKGVRTFAPIMFKRLEKLGINKTNPDDLTEEEVSKFARLDIDPTKISWRRVVDVNDRYLRKIETGLGPAEQGKTLETGFDIAVASECMAVLALANSLGDMRDRLGRMVIGQSRSGEPITCDDIGCTGSLAILMKDAIKPTLMQSLEGTPVFVHAGPFANIAHGNSSILADKIALKLAGVEEGESEDKNGYVITEAGFGADIGMEKFVNIKCRSSGLVPNAVVLVATIRALKMHGGGPEVSPGKPLPEVYLNENLEILEKGCSNLARHIENAKKVGIKVIVAVNRFTSDTDAEIQLVKEQALAAGADAAVPCNHWAEGGRGALELGQAVIEACEQPNPFKFLYDLDQPIKNKIETIAKEFYRADGVEYSELAEEQIKSFEQQGFGGLPICMSKTHLSFSADPKLKGAPLGFKIPIREVRASIGAGFIYPLVGEMSTMPGLATRPIYFDHQLLDNGEIVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIP5</accession>
    <name>A0A2S5BIP5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIP5"/>
    <dbReference type="STRING" id="741276.A0A2S5BIP5"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015372279" description="Peptide hydrolase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="118"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="325"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="423" mass="46940" checksum="41F86AABB1302320" modified="2018-07-18" version="1">MTACSMRPHRWPTWLCLLALCTLALASRPRPHSLKRRNPTYAPLSDQSLDALAVLSDRDEALDFDDPTSLLAKILVPRVSGTKNLTRVQELVEGHFSHLGWANEFDAKTPLGSKPMKNLVFTHDPSAPRRFVLAAHLDSKYFPTHPADQFVGATDSAAPCAMLLDLATALTPWLDERKKRVEELGGEEGREGQGETLQIVFFDGEEAFVDWTAEDSIYGAKHLAEKWSVTDTSPAPIQSTPKSPLRRISHFVLLDLLGAPNPLMRSFFPNTGWLFDEFLHSEERLGQAGLLWPGFEGNAYTERKGKIGVPERSFFVPRNAAGMQMHAGSIEDDHLPFMKAGVPIVHLIAVPFPSVWHTIRDAATALDLPTIKAWALILRLTVAEYLGLDPSIPPANANKKRKRDRSELVWPSLSASTQLFDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ12</accession>
    <name>A0A2S5BJ12_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ12"/>
    <dbReference type="OrthoDB" id="2528183at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="596" mass="62059" checksum="360FB40C2F04111A" modified="2018-07-18" version="1">MDVERNEREGSFHPMASDSESGSGSVSDGDPPGYDGRPPPPPIAPRPVLPKRESSSRSVEPLQPVYGTTTTSQLSPGAQSDSSNGSRSGSGSKTRTRRAFDELEDVMFSHPRTFLAMALRIAESRDAQVLISDDRTGKANSAYMHLVCPYRRAGCPLHIRLTRAKEGGWVVKGPGMHDTAADQKQRSVYRCRHPSAGYPDFTVGQSVQSWLDADARRVGGTAILPSVEAATPRSTTAAVPMSLMMSGSGESANGESTTNGGAATTTKPASNPEPSPRRSLRSDAAAASASDSVKQVDPLSGKAARFPRSAHKTGPVTQRPSGAKSTSGSPAAAAAAKTTPRVTPSPAAPAAAATTSGGSLSAPSRIDPDRALAPPFQRAIDLQAQIAPALGPGVYPHHHHHRVPLTYANGGSTRQATESPITHRPAADVSKANPYPPLTSAAMVAPATPPVSTKGTGDFHQPYYFAPPASTVPFTAPLIIRADTPVSAVTTTTAPAAAVVTPCVAVTDPSATAEWTAFLTRLGEPDLIPLAKVLGSAAISVTPAAFFSDAADDDLRASLLDQLPAGAVGLWPKLKLAKRIRDRGEAVWREMRSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ22</accession>
    <name>A0A2S5BJ22_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ22"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ22"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="322" mass="35816" checksum="3BD70972C39682DB" modified="2018-07-18" version="1">MANTTRAGALSIHGTNPQYLIPTVIRKRVYDTLYWKENCFALNAASLIDRAVELQAVGGTYANTRPTEFMCLVLKLLQLQPEREIILEYLRAEEFKYLRALAAFYVRLTFDSLNAYETLEPLLDDYRKLRYRGMDGSYSIMTMDDFVDQLLSGEMVCEIQLPRLTQRKVLEDTEGLAPRRSKLGKALGVMAVDGEAGADSDDDDGVEGGRGRYLSRSPSLSRSPSPASEAGEREPTPVYWTEGSGDESDGGPASGRNVKRRRPVIEREGGRGDDDDDDDDDAGRYISRSPSPAGSDGRYVSRSPTRSPEPERIEVEHIDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJA8</accession>
    <name>A0A2S5BJA8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJA8"/>
    <dbReference type="OrthoDB" id="2526597at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16759" checksum="3BE7EB6C45E18167" modified="2018-07-18" version="1">MSGGVPAEPARLCLLGSLPRAHASRPPRVRFVGRVAGLLPEAALAVLVDSEPTRSLAQTSSSSSSAVLIDLTLPVLQGGRAPPRLKDRIMITGEVTRLQVPIAAVPELQVTLPAPVTTPLDLRTVITVEQFEACEDLDMEQWRAAIRAVDAVRRNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZM6</accession>
    <name>A0A2S5AZM6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_7034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZM6"/>
    <dbReference type="STRING" id="741276.A0A2S5AZM6"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="750"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY69990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="955" mass="105286" checksum="E9DE356B158E0419" modified="2018-07-18" version="1">MPPQRTTARTIRSGSSKSATPSTASQHARNPTARQVHWGADQIHTDEQGYTDADEEENARLDRERAEVELNADVLPLNVLAITASRGKVGCCYLDVATNSLYFLEDQKDSAEWDLCGLIVEQLLPTFVLTSTNADDAFLQSLEDKLATLPLPPAASLASTASTSDYADRDKVRIEYRPARDFYSTAGKYALSRVKITHPPTSFAASDSSEADAERDAAIFDDRETRYRELRLESLLNSLTANPLTLGCAGALLDHLSSARSRAGDLEGHVIELNGIELLKLDKIMLINWDALMSLQIFRDEAHASAQSRATKEGLSLFGIAGIAKTPLGKAKMRDWFLRPALELEVIEERHDAVECFLREDNQHVVDTVKTNLKMVKNTPVMLKRLMSGSLNLVDWQAIWQLLYATIMIRDALLSLTRAHPIVAAEKFAQAFDATAFRNLASMLNDVIDWDEAKLQHGRFCVRSGVDEALDELRRKYGGLSSFLSNVAAEISTDLTAGLPSSLSTVYFPQLGYLVAISQEEHEGDPARFAVLGWEFQFLSNAQAYYKDDKCRDLDRYIGDLQSFITDKEIEIAHALLEHVAALRGELLDVTDKLAEIDCLLAFAQAARLYNWKRPVMTEEPICQIVEGRHPLAELCAEHFVPNNTSLIKNEEEAEVKLAGPDDPNVRNSSMIILTGANFSGKSIYLKQVALIVFMSHIGCFVPASDALIGLTDRIMTRVSTRESITRGSSAFMIDLQQISFALRNCTPRSLLIVDEFGKGTEADDGAGLFCGLIEYLLKLGAKAPRSLLATHFQHVFLNGVLSRQLPFILAHMEVFVNDAQSKGSETATVSSATAGAVDQLTYLYRLAPGLAVSSNALSCASVFGIPPEVLSRAAFVTDCLSTFQLDKLMPNDATELEENEQRELAEAEEIARRFLEWDLGGDDDLDNSRANGAPTDTVDELRQHVAALLDLKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZS1</accession>
    <name>A0A2S5AZS1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6963</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000153">
        <property type="protein sequence ID" value="POY70026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZS1"/>
    <dbReference type="STRING" id="741276.A0A2S5AZS1"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000009">
        <property type="entry name" value="Related to CDC36-transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="399"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="528" mass="54093" checksum="CC190C282E3FDF04" modified="2018-07-18" version="1">MLNRTQQSPFGLGQGSLPGGNRQPTQRAGQPPTSPGQTTMRAASFPMGAAAAALSPQSGATLPPGINSASLDPSDFPALGAQPASSGGLGSSSAASLFSSYASQAGQSSLSPGALNGAPGTATGGAPGSRRDFSADDFPVLGGAGAFGSAGQQLPPPSQHHQQQSQGMTNAAPGGGLNDLAGLSAGINGMSLAAAAAAAGRAVASPGGQEQASALAALQAQQQHRANLLGSMNGPRNPPVDKQQSWTDSPQPSANYPAGLLPNGSPSATSNASSPLPPNANAPDSSDPRQPVHSSPSGNSAGSAQTAALLAAAAAAGQAGLGGAGGVATHALPPPTSSVTLGGVPQTPAQQVLFSPADRYGLLGLLHTIKSSDPDQTMLALGTDLTNLGLDLGSSDNLYSTFITPWTDAKTAQMLNIEPEFTLPACYNVQPPPANTKIGNFSDETLFFIFYSQPRDAMQEMAAHELYKHNWRYHKELRLWLTKEAGSEPIQKTATYERGSYIFFDPVLWERVRKEFILHFESLETRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZS3</accession>
    <name>A0A2S5AZS3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000155">
        <property type="protein sequence ID" value="POY70005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZS3"/>
    <dbReference type="STRING" id="741276.A0A2S5AZS3"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="452" mass="50579" checksum="8E250AD7B383A8BF" modified="2018-07-18" version="1">MDEHYDFIILGTGLTECVLSGLLSVEGKKVLHMDRNDYYGAESASLNLTQLYKKFRGTEPPAELGRDRDYAVDLIPKFMMANGEMTKMLVHTDVTRYLEFKQIAGSYVLRDGRIAKVPATEGEAVRSSLMGLFEKRRARNFFLWVQGYNEENPSTHQGLNLDKNTMKEVYYKFGLEAGTQDFIGHAMALYLDDDYLNQPARETYNRIMLYTSSMARFGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLDKPVDKIEYDDKGKFVGVTSGGETVKADKVIGDPSYFVDASGKGGADKEDKVFLEGHVVRAICILRHPIPNTDDSDSVQIILPQKQVNRKHDIYVAGVSATHNVCAKDVYIAMVSTIVETGNPEAELEPGLKLLGPIHDKFISIAPIYSPASSGSHDNVFVTRSYDATSHFETMCDDVREVWRRATGEELVLKKREDALQTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZW3</accession>
    <name>A0A2S5AZW3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCF C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000152">
        <property type="protein sequence ID" value="POY70045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZW3"/>
    <dbReference type="STRING" id="741276.A0A2S5AZW3"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="102339" checksum="9E5E36995FC68BAB" modified="2018-07-18" version="1">MQGGYQDDDADDSGPVFVIKKKRSTAGKPRTKLSSLVDSSPPPPPAPTATPATEEQAATDGQTGDDAEGNTPVFRSRVKKSARSSGLTAGTTPRGASATATATTTTTARSRISFGGEAEAEDDGPVSFVKRSASASALSAASGTPRRSLLRPNAMPSASGSSKPAVESATTAAPTATPTAHEQRSVYSKEYLDELKRGQMNSPRGGTAVAGTATTSSGFDDLTKSKFGADQLQDSTELPSSQQIERARQRREELRKAGLAAPVSRGGGGDDENGGFISLQVGFANKGGESRLVREEDEIGDGDEDMAAFTDSLSRLPLGKRANALAARRMREEMGEMIDDVEMDVRDQDDEMREWEEAQIRRAGGGRDEVERGRGAEGKGGKDAPYRAAPIPQSSTLPSISAVSARLSAALQSLTTSHALERSALDHFEKERSELDTQERELREEVVKTEEKNRWFGDFKDEVEDWSAFLDEKFPQLERIEAILLSIQRERSEIVSRRRFADDADDVALFTGAPIAPAFKLPSAAATSEDQQDMPMSDATLEEDLPPRSVARTTRRAERERRYRERVTSATAPAEEQTLGYDSDADLSAGDRSDLQDALTAAETDLAALFADVKAPEFRDPNLVIRKRFEEWRERYGDEYGMTFAGLSLAQVWEFWARVEMARWNPFELDELPRTPSDLAAYQWHQALSTYGHKERLENGNDDDEEEEEEADESTEVVNAIVASVAIPRLSTLARQTYDPYSSRQTTAALRLVDEISYCVETNSPKFEGLIYAFFFRLRMAVAAQQSLVLPHLANLSVPALAFDPSTFTARLSFLRRSLKLLRTCQRWRRFMRALRIPVVPEQVAQGASAAEDGLLEVGAGATFDELVQREFVARTVLPVVEAAWASGGDEIAKQASHFFFGSPSDIPLPMIEALPKDIPPALRRRLEGENIGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZW8</accession>
    <name>A0A2S5AZW8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_7043</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="PJQD01000161">
        <property type="protein sequence ID" value="POY69951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZW8"/>
    <dbReference type="STRING" id="741276.A0A2S5AZW8"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015608765" description="GPI mannosyltransferase 1" evidence="14">
        <location>
            <begin position="29"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY69951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="424" mass="46873" checksum="BD82F118EFE58A94" modified="2018-07-18" version="1">MRLRTAIGLAALLRAGLLLWGTYQDAHSQVPYTDVDYFVFSDAAACILRPTRQFCGQAKGPIAPTWLGDPYSRATYRYTPLVALLLVPNEWAHPAFGKILFCCADLLVGVLLYRLLIGKKTAATRSTNAVAAIWLLNPIIANISTRGSSESVVGAIVVTTLSLAERDRWDAAALVFGLAVHVKIFPFMYGSSLIATLVSRARNRRTAVVSLLRFGALSFAAFMALNTICYLVFGQPFVQETFLYHLSRLDHRHNFSAYFYPFYLSSSPSAVALPASGLLQSFARHPLAAFLPQLGLSIGLGFAYGARDLSFAWLVQTFAFVTFNKVCTSQYFLWYLWLLPAALPRIAMSARRTAVVGVIWIGGQAIWLSQAYRLEMLGESVYLRVWSASIVFLFAQAVVLGQLLCAFKPDQLHRTRSSARAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B031</accession>
    <name>A0A2S5B031_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B031"/>
    <dbReference type="STRING" id="741276.A0A2S5B031"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="344"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="464"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="766" mass="83342" checksum="8D8B52577D9546AF" modified="2018-07-18" version="1">MSQYDQGMSFPNPNVQGNPYIYLAVYSSVPVYEMMVRGIGVMRRRQDSWLNATQILKVAGVEKGKRTKILEKDIAQGVHEKVQGGYGRYQGTWIPFERAVDLANAFGVSHLLAPLFDYTAPPPPVSMNGAPSPPSLTDTYAPALGGQLPPPPMQSTSQQAQQHAQQQQRMMQQQQQQQQQQIMPQDASAILQQAREQGLMSTPGLDEPHLMPPPMSTGGHKRAGEMLDQDDVKRARTEVTNGFTPSGSMNGYGTSPAPPTPVAAEPIPPPSNFRTTLKFSNTTPLEGTAAVDAASLERQRTALKSIFSLDPEPSADGQASPSIDLGTVFPPDLRVDPDVPIDENKHTALHWASALARVSLVQALVNYGADMYRGNNVGETPLIRAVLVTNNSDHDSFLRLLDILGPSLRTVDEMGRSVLHHIALVAGVAGRAASARYYLETILEYIATHDSGRFQDLIDARDLHGDTALNIAARIGSKSLVRMLLEVDANKLIANKLGLRPTDYGLDDPELSINAAEETLNALKSPDVAPEASAPVLASQDVLRSITKTVESLSTTFTGELTSKTAALDRKKAEVQALARDLAEQRTLLAHWRREASRVDELAQRVDNLTRAVEEEDAFDWTGRTEIDGSPASQLAGPGFKYRGPSSTLSNLPPGISIEFDADPAIPETTGDEVSGEALVHMLRLQAWYERVEGLMRHRLEKLEDGTVEKENKLRKIVAACCGVEEDVVEEMLEGLVRSLESDPSAMDLPRVAGFLSRVKEGGLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0E8</accession>
    <name>A0A2S5B0E8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0E8"/>
    <dbReference type="STRING" id="741276.A0A2S5B0E8"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="7">
        <location>
            <begin position="43"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="6">
        <location>
            <begin position="717"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="893" mass="101019" checksum="54E903EDB7CC0EE4" modified="2018-07-18" version="1">MLRQDLIDPATWSWAQVSAGQSGDDSDLDFSSSGGLPDSLATATWRECSKMPSEIHTELFAADMIPNPLGGSNEQAVQWVGEADWVYRCTFDRDGSGERSSEAGAPFADLVFEGLDTFATIYLNGQKVWTADNMFRSWRVSVTEQLEQEGNTLYIVFRSAFRRGRELEIAALGRDTHWPCWNGDPSRLFVRKAGYHYGWDWGPTLMAVGPYRPIRLERYQVRITDFWPRTTVSATLEPRMSLSWKTSPIDQSVTVVARLVSATGTRLRKTTVESVACEEVLEWSLDSDEVELWWTSDQGPQPRYEVQLDLVDERSGEVLDSVSRKVAFRRLEVVRAPLAEADGHSFVFVLNNRPLFLGGSNWIPVDSFLTTGTPERYRRLLELAREGNQTIIRVWGGGMYEEPIFYDICDELGILVWQDFMFACGAYPAHLEAFHQNVEAEALEAIKRLRHHACLAIFAGNNEDYQIAEAEKLEYDPSDRSTENDWLATNFPARELYERVFPALVEAHSDIFYWPGSPWSEENTRDQTEGDLHCWDVWHGSQEPYQEYGRLGGRFVSEFGMQGCPDSSTIKTFFNEDDRDRDADSLAFARHNKATGWEGRLAKYIADNVRRGSSLDEYAYATQFVQAEAVANAFSAWRSKFKGGVAGAQCAGALVWQFNDVWPCTSWSIVDYFERPKPAYYTAKRALAPIALYGQRTPRRVHSDPTSAAEYVQLVDVRVGVSSSLATEVAADVEVVAFDLGSGKRIRHWRQQAQVRANRSCDLMKLELPSEYADPERPIVISATLFEREGRTILARLSLWPEPFKYLRLPVASEVDLSVEIGSWLTDQAARRTTCVTVRAARPVKGLVIRSSDGEARLSDNYLDIMPGDERSIDCWTEGGTSDIEWRYLGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0F7</accession>
    <name>A0A2S5B0F7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000138">
        <property type="protein sequence ID" value="POY70272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0F7"/>
    <dbReference type="STRING" id="741276.A0A2S5B0F7"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="155"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="282"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="529" mass="58000" checksum="085CB30E9ED0BF80" modified="2018-07-18" version="1">MERQAANRRAQYKNKGIFGQEELRRRREEAQVEIRKQKREETIAKRRNLNAPSGDADSDDESGADSTFLDQLPVMIQGVFSDQPDQQLDSTTKFRKLLSKERNPPIEKVIECGVVARFVEFLRSSHSMIQFEAAWALTNIASGTSEHTQVVIESGAVPVFIELLSSPVLDVREQAVWALGNIAGDSPKCRDYVLEQGALRPLLALLNEPHKMSMLRNATWTLSNFCRGKNPQPNWELISPALSVLTKLIYSLDDEVLIDACWAISYLSDGSSDKIQAVIESGVVRRLVDLLMHHSTAVQTPALRSVGNIVTGDDLQTQVVLASGALPALLALLSSPKEGIRKEACWTVSNITAGSPQQIQSVIDANIIPPLINILQHADFKTKKEACWALSNATSGGLQEPNQIRYLVSQGCIKPLCDLLTSTDNKIIQVALDGLENILKVGDADKEANGGVNKYALYVEEAGGMLAIHNLQHHENLEIYKKSFHIMDAYFPDDEEDTGVADAPVDASGAFALSAVQAPTGGFQFGQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0J2</accession>
    <name>A0A2S5B0J2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000128">
        <property type="protein sequence ID" value="POY70293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0J2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="228" mass="26469" checksum="1F952CAEC61F9D3A" modified="2018-07-18" version="1">MQAGSLNNHDSQMRQWLDGVHLNEVLHNYLVIYNKLHAEPIHADQSRAESTWWYVCGTGTARDPCLVLAPAFELKGTAHLMKATNRWEILVPPTSPDYLKVLPAPCIFHGATVEHEALQDAWARGRCSSMGEAWTIDSEIIRSLLHQTANLSFVSITAYPFDWPVMEDEIMPYGDYSTSLLRLMLDTPKREVYYIQIHHSLRLRRILDEVRDPQWNYKSFEPRSRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0U2</accession>
    <name>A0A2S5B0U2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000134">
        <property type="protein sequence ID" value="POY70281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0U2"/>
    <dbReference type="STRING" id="741276.A0A2S5B0U2"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="511" mass="56864" checksum="B1AEF604DB71091A" modified="2018-07-18" version="1">MLARDFIDDSLYNPHYGYFATKVEIFDPDLAQGTASRGARLADEQVLNAASRAQGFDFGSFRSTAAFEDEVARRYQVFEGTGSGHDDAASFEAVAVGSGVGRQVWHTPTELFKPWYGRALARYLVAQYKLDLFPYHDLIIYEIGAGNGTLMGDILDYLAAHEPEVYSRTKYRIIEISERLQDMQRGRARGTAGTSLVGGTGDGGDGGAGRLGKEKAKRRGHEDRVEIINSSIFEWDRVVPEPCFFLAMEVLDNLSHDVVRYTTDTYEPLQCVVSVDASGDYTELYEPVSDPLLARYLSLRARLPSSHARSHPSPAIPSLLARFPFLRSLYATIPFAPNLTRPEFVPTRQLELLEVLRDKFPNHRLLMSDFETLPDAIEGVNAPVVQTRYAGETVPCTTYLVQPGFFDIFFPTDFHTLAELYSQVMATSSSSSSDGAAGPDSIGYFSRSSAPTSRASPPTEDSSRRRRPLEVIDHADFLEEWAELDMTRTQDGTNPMVDSYQNAKFICEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0W2</accession>
    <name>A0A2S5B0W2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000127">
        <property type="protein sequence ID" value="POY70301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0W2"/>
    <dbReference type="OrthoDB" id="2528145at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="588" mass="64720" checksum="26B51C598CD4A69B" modified="2018-07-18" version="1">MPSYAAWAGATLYCLYCEVLSAPVSILVESVLPGQAARPTLAALRWPFWMMATLALWIASLVQTGVLVEEWTMDGLGTALNSRLASTSHPQKNASGLIDSLLLAESPSSSMAYTETLSALLDVPLPLPVQSGPPNAEPFSEKDVREWNDANEVLRLKMERGMEESAARWLDVLEWVPTASASGSLSDGDDRKVDPASSSSSQGRRFERFDYLAAVLAELEAVNSRKPTRHVYARHVPSAEEWHRLERAERAAKERQAGEREARFQAWLDAIMTGASPFTGRSSAGAGDDDTPPRSDKDLEAERQRRAMLDVPLAGPGQPGLTWRDQLREQWALIFDTAQGGVLGNVERALEALGGDSGLDADEEDGSVWTPDPVQIMAAHHMRAQVASTLAGIDSTREGSRFPPDDPEWERATLPTLLDTVSNEHMSLEQLAIRVDRRARRWADRFVDLMTRKSVARSRSPTAPTRLSIRERTQLLRDSPFPAFMRSVDSTFKAPRDPAHFRIGISPHDLANAIFAIRTDGTAAMAPRPPRSRGQEEGGVSAVQRELWRRAASDEELEVVRRQLAAEQGAKSSERAGPARVPLSRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B109</accession>
    <name>A0A2S5B109_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B109"/>
    <dbReference type="STRING" id="741276.A0A2S5B109"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="340" mass="37100" checksum="2C5564B65B40406D" modified="2018-07-18" version="1">MPLRLGSIRQTAALCSTPRRPLLVTTATCRSRAMATVSGQSFRLAMIQLAAVGDGSDKAANLAHAKEMVAETVKGGKEGRKPDVVVLPEIFNSPYATNMFRKYAERIGWTPETKDSFDVAKTESESIKLLSEAAKEHGVWLIGGSIPELSEDDKVYNSSPTFDKQGNLVAIHRKVHLFDISIPNGITFKESETLTGGDWQTLVDTEHGKIGVGICYDVRFPELAMTAARKGAVAMVYPAAFNLTTGPLHWDLVQRARAIDNQIFVAMCSPARATSGDGYKAWGHSSVWDPMGRCLEQLDEKEGILFADIDLDALKSARAGIPVTVQRRFDVYADVSNVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B192</accession>
    <name>A0A2S5B192_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6479</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B192"/>
    <dbReference type="STRING" id="741276.A0A2S5B192"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="504"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="559"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="67597" checksum="05274E3AF74C2653" modified="2018-07-18" version="1">MSPLAPRLAASTASAHASTSQGATLPGDGDLWSSILDSVKTSKAVQTKQCLVVGANRSGKSSLVARLQTVNGQLPPHLDSDDHDSYNGKGKALDLGMSYEVMDVRDDSDERDLLGRLGFYQIPTTEPPRTRLVSLALSRAALIDSLVVIVLDWQKPWTFIRELKYWIEVLEEALGEQSQTEGGEDPVEEGKRRDLDTVEATWRAYQEPTANGTMPSTSTASLHSLDAPLPTGALLENLGLNLVIVCTKADRMDMLERDREFSEDKFDYVQQLIRTVAMRYGAAVFYTSQTVPPSFTKLRQYILHRLFSAPSSAQSASASAAPGTPTVAAARSKATPTPRQSARASFPFLHRANVVDRDQVLVPTGWDTWGKIKVLKERFDCEACGQSWEAGRDARRRMREERAKGEARDDREEGGLLAEYESVVTDFDAQNRPNGLPKLLEAEKEQTFLRQHYEVLQAEIAKDPRLAFRQPGSMAQNGFGPSAVGPMAGSSFNLPTVATTLDRAREAAGASGRTGSSDDRYRTSMSRQNSNISQPARSPQLGSSTSPGIPSAATFLSRTSSQQSATSSSTMPTTPGSTTAGNAAGGNQVLADFFQSLLTARTAGATASTTGATASGGAAGAVRPGVRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B220</accession>
    <name>A0A2S5B220_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B220"/>
    <dbReference type="OrthoDB" id="2521637at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="193"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="401" mass="43347" checksum="C2F53BE27E80345A" modified="2018-07-18" version="1">MSTPDDVPAMIADQRVATATLAPYITGLVTLVMLTGLFFGLFIEFVKKGDWKASPRRVKVVACFVFAFMVFCLGLAYEEIVDTAVSQKRSAAELFLGPAQSNILPILTGVTSMICQTFLMARAAFLIPSQYLRYAFLVGTTALILLALAGAALFSTCGYLISKLTLNRIAQSFFDRAMPMNYFVAEAIWLWSSAAADVLISIALSISLHKRIRGFNATLDGVLKHLILVGLRTAAYSAAASIVGAALSTAFANSSDYHVTTIGFAWWVLLPGLHAISLFTTLSTRRTFANALGMNGGVVSPMVHDIELPHEMRRGSAFHSTTQVRAEDDAGKSMSQTSSVGGGAGRGGRRPPVPLVVKVEQERKITYDVRSDSDEDFLARESRGRRTIDGSPRDCSSAFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B245</accession>
    <name>A0A2S5B245_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B245"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="120"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="254" mass="27730" checksum="B088DF8013F14F9D" modified="2018-07-18" version="1">MPDSLFGSSDDEIDDEQAHAGATEPGSEASEPAVVVASTVCPPIPGLYILRQAIPTDVQQQLVLDLSERVWPGRTDQVMVFTSEERPLLPDYLRPFLDALPSALASLPADVQSVILESNRPQQAILNLYQPGQGISSHVDLPDRYEDGIVGLSLLTSTVMEFRHVSDPSSEEQPSGSQPPRTPPTYAVRLRPGDLYVLSGDARWKWSHGIPYRTEDLVQDETGGPVRVLRGVRMSVTLRRMKQGADVIGQHGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2F4</accession>
    <name>A0A2S5B2F4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000095">
        <property type="protein sequence ID" value="POY70950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2F4"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="249" mass="27115" checksum="F817025F6E342034" modified="2018-07-18" version="1">MALRDGNRQKLETLLNETPEVRIVLKPYAPPAALGLAGFASSTFITSMWIAGWWGNGDSPGVFFPFVMMFGGLAQFLAGMWGFVARDTLVTVINTMWGSFWLSQGILYYLNAAGTVPPQSIHAHFPELAAWFIPLAAFTWSGAIAALVRDAILACCLFCLAIGSTIACCLFAYGDAVERGIKAAAYFWMLSSLLAWWRVTNYLIEEGYGPKSTAARFVPVFRTKHEQHAPLVVPGLGEPGVKRGMPGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2M2</accession>
    <name>A0A2S5B2M2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2M2"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21040" checksum="06B3A1CE0ACA2F45" modified="2018-07-18" version="1">MSGLRQARKTTQLASQLQQIVAGPSSRQLPSIVEGLTIRSEGVKGNAGARHFVKSTIPAVRFANPSLRISFEQVPVVTKKKRRTPPSPAEVEGSAQATEPTAEVATSEAAWTQPPGLTVTFTDPSLPPAFFPLPPQKSDRLVSTFWSTFGQEETVRAWATGKASAAGPESGAETVQVVDEVPVKGDGETLVGGEPQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2S6</accession>
    <name>A0A2S5B2S6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2S6"/>
    <dbReference type="STRING" id="741276.A0A2S5B2S6"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="213" mass="22864" checksum="C84CB0FBC693F46F" modified="2018-07-18" version="1">MFSRRAVQAVRSYATQAKASVHPPIQIQGLAGKYAGALFSAAANANALQQVESDLKGVKATVGTDAKIHEFLSNPILSHQDRASGLDALLTASVKGGKPSDLTRNLFTVLAENGRLYETDKVVDGFLEIMQAHRGEVKVTITTAQPLEKDLQKRLEDALKSSQVAQSGKNLVFENKINEAQLGGVVIDVGDKTIDLSVASRVSRLNQQLEEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2U5</accession>
    <name>A0A2S5B2U5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2U5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="402" mass="43146" checksum="EF745B449A6EA912" modified="2018-07-18" version="1">MDSFSASDSLRALCAPLCCCLRGSVALSPSTDPLAHFDESAEQHAQDARLWPRNETSNELDGTLYSTEYEARIASANGGLQAPQDSTPQAGGRFPRSRQRRRGGDISGGGTDDGSGLTRWTLFRSWLRGGNQVEGAIRLGEAEDEGDFVARTNESSPNRLFGYAYGDEDAAPIALDDVALPPAPPHRAGPVPGALAPPPPSSSDLTSSDDRSNLDGEEAAQKEERRRRRRLRRRARELGLSVEDYEARIGAGWIDETQAETAGSHLAAAPSQPSTSSSRRSHRSAPDLDDSGAPGSGLAPEISATTLDLPPQSRSSSSGERRSHSSNQSVSSHATTTSSSSSSRRRSRKHEEQTSYAAPRSPLEGPTGEYYEDEHGQLRERTEATGSRYDHIGVLPGNLPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2W8</accession>
    <name>A0A2S5B2W8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2W8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2W8"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF85">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="470" mass="52147" checksum="5F12E4C30AC73047" modified="2018-07-18" version="1">MVYQNDKEKGHSTSPASSRHPVQEDSSDFTEADWELDRQARSNLGKIAGMAKDLHLTPHQYLVCVTCTYVLYIVFEMPSNLVLKKIGAHIAIPTMIVAWGTVSCLTGLVQNYHGLMAARLILGLCESGLFPGLVLYLSMFYRRHELQTRISLFFSAASLSGAFSGLLAAAILNLDGKGGQAGWRWIFYLEGLATVLFGFAMFFVFPRSPAHSRFLTAEQKAHIVRRLKLDSPAGVDSFEESFSWAECRKAFTSPHVILLFIALFGNGLTLYGFGYFTPTIVQTFGYSTIQTQLLTVPPFVLAFFLTMFNAWWSDRYGRRGLCSILMSLIAMVGYIMFYKSLSTAVRYVALFLAISAVYSTAPALVTWLPNNSAGHYRKATAVALGFISTNSGGIASTWLFPTTEGPEYRRASIVLISMTILIIVASTANLVYLRRENRRKAAVRASGKSDIDAASWATEGDRHAHYIYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Z5</accession>
    <name>A0A2S5B2Z5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Z5"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Z5"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="363" mass="40680" checksum="BC08A9A1EBD2D2FC" modified="2018-07-18" version="1">MVHLLDYISGQPPSYHRKKHYTIKETLGVGGFAEVKRATRKDDGREVAIKIIDKDRIRDHAQQLYRQNTLMTLKHPHIIELIEWFESKGHYYLVFELAAGGELFDHLVESPNCRFSEAEAREIVYALVDGIRYLHGRNIVHRDLKPENVLYRTPPGSHPEVGHDDCVISDFGLAAYVEPNGGRLYTIAGSAGYSAPEMYPPEGVINGQCQGKGYGLKADMWSLGVIAFCCLGGRFPYKKTDPVELADEARSTELYFPRSWDTVSETAKDFIRKLLTVDEHERYSADEAIEHPWLRAAVSRPPSPAAGARPAMLGLSDMTPHEYNLGATLSRQETVTTHAPLMEGAGLEKRTTLSAEMDKRAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B370</accession>
    <name>A0A2S5B370_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">triacylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B370"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015377388" description="triacylglycerol lipase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="459" mass="47691" checksum="F93D191A3FD50737" modified="2018-07-18" version="1">MRSVLVSLSALAALVQLSAAAAVPYRRWNDAKPGDVTTDPLPPTQDPFYNVPSDVASKQNGDVLKSRPVWTEFDAYSRGTYQLLYRTTNATGGATAAVTTVFAPLKPANPPRINLLMTPIDSACPNCEPAFALQSGSGSNGTSFIVPEIALDIVASLSKGWYVTVPDHDGLNAAFFAGVVEAFAGIDGLRALLNFATVLPCADNYAAALRGYSGGAHAAAWVNEYLQSYGKGLNIIAAAYGGTPVDATSTLNLLNEQPAAFLDVSSLAGQANAYPELNAFIAANLNANGTRAFQLARTLCNTQLGPLLAGINVYDLFKGGAATLLNSTVTQKYIKLNLLGNPVGSDLAPCTTNGVISVPTFMYHSSSDTTVAYAPVPAYVKSQCERGADITFATVPGLNHTAAAVAYLGDAYTYLEQAFNGTLNTTSCSDRFGINAIPGTAAYSAAIGPAAAALLASET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3C3</accession>
    <name>A0A2S5B3C3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5591</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3C3"/>
    <dbReference type="STRING" id="741276.A0A2S5B3C3"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="10">
        <location>
            <begin position="38"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="703"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="11">
        <location>
            <begin position="937"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1073"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="892"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1086"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1105"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY71279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1151" mass="126753" checksum="E08E8A56C4D601C2" modified="2018-07-18" version="1">MDDFVSSHDDRRALTAQTQGFEDGAVYDADQTEAADAPIFSLGQVQFTLPSALFSLSCANNVLVLAVTGSAPTLRSTPAGPTSHPQIIRIDLARPTEVETVNISLAPSQGQGRGTPAPSAPTLHKVHVDPSGRHVIVSTSSGENFYLFVGTLPVNASGNAPPTRKARPLPRLKGAIIDSVAWSPSSFSSPSSSTTFSTREILLGTTTGQVLETNLVDPALASDSGGFSLPVPGRAASPEKYVKQLLTLPERQAIVGLRSETWGHRRLAVIAATATKVYQYVGDGAALGASKHGRDEEVGLLETVMHVYSAGDARPKMLELPSDAQRSELHFCAPMRTDGKEGLERPKTLAWMTGPGVYHGNLVFPSSSSELQLGDGVIDSASLIPYPLDSTGRFSAEEQPISMALTEHHFVILYEDTICAVDILTDRVVYFEELELTDGSRPIRLSTDALRKTCWMYTDTSIYELVIRDEDRDVWKVYLSRQNWEQAKRATKTQRQRDTVLAAEADAYFAAGRYIPAAQAYAQSSKSFEEVVLRFVDKGERDALRVFLSAKLESLRKTDLTQRTMIATWLVELYLAKINHLEDLAAAERLSEDGGNLLVERSIVEEDLRHFLSSYKNDLDRRTTYDLLERHGRDELELHYATAVGDHERIVRHYVVQHQWTRALQALAKQDSPELYYPFASTLLKNAPKETVDSFIRQPRLDLRRLIPSLTAPRPRSRISPSSAPYAHLIRYLEHAIFESRNTDAAVQNTLITLYATSPSTEEAAFVRFLETAPADPDTNESYYDLDYALRVARAHKRVQACVVIYSKMALYESSVDLALAHDDLELAKICADKPEDDEMLRKKLWLKIAKHVVGQKNDIKAAMQFLQSTNLLKIEDILPFFPDFVVIDDFKEEICSALEDYSAHIERLKDEMTEATRSAKAIKADIAELDNRFVIIEAGEKCGTCRQQLLTRQFYVFPCQHCFHADCLISEVTKTLSPTQLRRMLDLQARLAPSAAAQTGAQVIRNGKKASGIFDDTTAQGLKLATASVQAVDQLRKLVLPDALLSAIGGAIPLPGAVDGAAALTNTMRSLGSGLAPRSGRPATSGRTSRANGSAEQAASRALSAREKREEEEKEALRTQLDDLIASQCVLCEGSIDAVDRGFVDEGETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B407</accession>
    <name>A0A2S5B407_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000083">
        <property type="protein sequence ID" value="POY71523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B407"/>
    <dbReference type="STRING" id="741276.A0A2S5B407"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="152"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="849"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="891" mass="94550" checksum="5ED6A4208DCB6334" modified="2018-07-18" version="1">MSWYPPPPHGYGGHYPPPPPQPQPDYGAPAAGGGQYPYGGAQPGYGQAPYGGQYQGGGGGGYYQPPPPAGPYGQPPAVAPPLGGAPPAGYYHHQHHHQQQQQHHMAPPPPVHQQQPRYDYAPPPPPALVPQSSPAPPLKEGELRPPPDVAHDPNSFRRYFKLQLDHLTYNSKPVITSLTLFAHEHAVRMASVVAQCFDEHLRTCPPPYILPAFYLLDSICKNIGAPYVALFSRFIERAFLSAYHSVDPSTRTKLEELLGTWKTGGPDGGELFREPDEPREGARVQRGIEGALFGARGRGDGLLGRAAKDAEMYNAGVQQLPHTATTTERSGVLYDVRRLLTLRQDVLSSNPADQINASQIVALKKLENLILNTQLTTEQVTQIRNQLAALAPPAQAQAQTQARTSASPAPPPPPPPPAAASPAVAQQTLANVLSPLMPAPQQPGPSSYPQQQRQFGHHFSPPLPTAPPPQAAAGRHFSPGPGAGYQQTPTPTLQATPAPLPPQLTSQGASNASGGGNVVNGIDLGLLSQLSASGALANLFGSAGTSSPSLGNVKIEAGEVKPRVEEGATVGKGKDRGPVVEVDEMAHVWEEEVIRMGVTLNAGDLSTPRPHALALLYLQLLPLQCRQCGLRQPDSRTGKRKMDEHLDWHFVHKRRIREATGRASGRSWFTSEEDWYTSDSTHHPLSAADQPSSSLMSAGAAASAASAAGSGAIDRAALQKQKVAVPAAGTPEAELGLGDKPCPICQDRFKSEWSDDEEEWVWWNAVVVDKTLYHATCHAEAALSRSNAAASVAASRTSVRTSRESTPTSLAGSRKRKAGSVDPLGNATSPLKPPVERAPDQDGQTSKTAASEPADAAAAGVGVDGSGEPDAKRVKAEPQEAMPLFRTDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B409</accession>
    <name>A0A2S5B409_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000083">
        <property type="protein sequence ID" value="POY71524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B409"/>
    <dbReference type="STRING" id="741276.A0A2S5B409"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000008">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="105"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="196" mass="22315" checksum="DBCA2BD4EBE92200" modified="2018-07-18" version="1">MKQIYKEEEFEIPEGVTVAIKARIVTVTGPRGTLQKNLQHTNMSMRITAPSDKAIKPVHKVKLVVWHGARKHVACLRTVRSIIENMVTGVRYGFSYKMRLVYAHFPINVIIADNKESVEIRNFLGEKRVRNVKMLEGVTISESKSQKDEIIIEGNDVDMVSQSAADIHGQNSFTDKKRREKCLVKNKDIRKASRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B460</accession>
    <name>A0A2S5B460_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000083">
        <property type="protein sequence ID" value="POY71535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B460"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="206" mass="22941" checksum="242572411A4E612A" modified="2018-07-18" version="1">MDVARATAAQKRLDELALAHPSESPLGHFLASATIVNYLDVTADIFSHTEDYADVQTHLAAERELFVPWVRSLELAFTTWVSDHLRSDREMRNRLKASARVYAEFLTARREEVGTLVVARHVSQAKDLVLYCTVATISQRLRKAYPSFVAPSSEPAQPRHAASSSAALQNLMDSLGPHPQLGQITRRAARVYGHRSPAAWRRTIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4G1</accession>
    <name>A0A2S5B4G1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4G1"/>
    <dbReference type="STRING" id="741276.A0A2S5B4G1"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="451" mass="48644" checksum="BCD52175240C7D2C" modified="2018-07-18" version="1">MAYPPVPYPPVVTEIGRSAALESAAETPLGNAAAGPAPPPGFPAELAVPANLATDGHLGRGGDDTLLSGTPGAQVDESLAHHQAEREAEAETRPDREGSPAQPARRPDAAAAGDSVEVLETPPYHQRPKPSRAAVHRDTSPLASSPHPNEHDAPTASGPHPKARIATEIIRLEHKVAKLRRARQIQRANERGEHDSTERLEQLAEKWREAGLLAEELLRDRYGVTEPSTCSSASSLSRPAPLFASDDAAPSSGTTYVSPQAGYSPNTSAASLRFKSTWKSDSDRLDDFKRSVAAAARARGVSEKRILREMDDDDEEEGADLPDPETAFERMIPLSKKVKREETPAEESFAARAFERLATPQPAYKSTSWKPPRQDPAKRAPLSDSRKAPVSTGDVLDLADQDDSSDDELMKALDAAMEATRRRRERDDRVGEIDQGQAKTPEESGRLSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Y6</accession>
    <name>A0A2S5B4Y6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B4Y6"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="2105"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1091"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1375"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1538"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1116"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1142"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1559"/>
            <end position="1570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2300" mass="247847" checksum="040B415419AA5997" modified="2018-07-18" version="1">MTTSRPPPAPSKSRQLPPTRAPTTRRTRLAQPNADEDNVDRLANDLTQLKVRPAATRTASATSQGAPARRPAGSTRSAADTTAKQEPAPTAAASRRSALAPATKRVTSSSTRSVQDVEAPAKTPTERAQSAMKALNGALASLSALNKAGYRAGSSASTSALPTGTPTSSRPASAASTARSASVARGNASSIAPSSSSSSLRASAAHTATKDKVERAAKDASRALAELRQLVREGVLGGKRVDIEKAATGIIANLVEMELYDRALTEIRTMRASLLSWWQAVPHSDAAAPSPAATGHAADFLFALPAPAYLEPPTLAEALAAGSARPTLADIAPLVETARQCLLACVFRSSMYTSAERVTSLIAAIKADASCGGPLAWRKLVEAHCLQDSAADVEVVDKEKLVRRIDASLTSMFGSITKGCGAVDGDADPKELLHLRLYALELYATTSSLSPGALDKLSAFFDQVRKTLLLYGRSAEKASQSPSQISDGVSAGFERTLATLERRGLLSEEAKATERWRELCDVVIHIARRANDLAAIERVAQLGGSADNAALPEADIDADARAAQLTAKVVSALAVFEIWVKTNEDRSVAEQLRRTASLLPTLTRLRCAGSTTAERKGLEAQTVVRLDKAIDRLRYVLAKKVKNGRRLDQLVRHTAGPAPLPDDPDTLVNATLDCVTTHCEQVLLRLSPGKAKTQLATTTIDSLLVLAHSSFVIDDRATHSIALRFLQRALPVVGLFEDRAASIDLDLHYAIRALSSALYNLGGILYNAGSSATGLPFIQAGCDLASAALDLDEARAVFSTSIDALDSFRQLSLDDDVPPESAREEERQRHDAVKDLERVMARRWDLLALTQRALGDKAASYKASIASVLAQPGSVLADLRDKMSKNSLSVVAADFADLNSSISRLTRSATFDLLLEPDSIPLSRTPRASSLDLETVGALLELQSLSLRSHIDTEEGRCAALFVAQAAATSYSADKLPLRKARSLVESLRLADFSRDPDTLGKTLLEITDLCRHSDLRDDSGLGHFAPLYLASAHIRVAQAVQQAPAVPASIAGPKIADHARRALTELANLIPLRNAHAHGQNALRSSVSGHVKPVDLTPPSPQSPPLAARSRRPVRAAATPARARNANRRPVAASQIHVTPPSAQQAQGSLRSSLARSQRGSSTAIRNSASEQASFDPDLRDLLHAFATMLDLRGETALYLEFLEALHGLTGPSSPSADDALVGVNVTLARAQLELGQLGRAGLVLARAVRTCEAVEDVTSATRIALWLCSAEYHALLGNHERSAESYEHALALAEELGDSEDVPGSSRSKIVARTLLIRRASQAAHACSIMQQRKGEVGGCLGPALQSMRLATRALHNVTRLAPRPQRREVGAAQVLTNSNGRDEATLSPPAPMQDRREPASFLAEDHATLYWSLARELISRTLRVAQLHLVRGTPKSADFFAQQAQNLAEDVGAQQDVILALSLRLTVAIGWSREEEANRLLEDLSRQSRLAKGHALSEALAAQAQWHQSGGDPATAFTLFDQAQDALDSLSQTLNPASHKEEDSPQQGRRASVHFAQPTPSPTTGGTAAATFADWLLPSLQSRLIRSRVRLLFERKQIDEGRRLLRRLKRVTALEEDKAEELRLLAAVQSKDLVLRCASDPVLGMLPDSVLALPAFGVSAGGPAAAKVGTPRTGPSALNSIKDIEHLLARALSLGASRSEADKLSELSVVSAAMRAMQANVSKGSKRMAGLVAHALDLGTAVTLRREMVDAITARQSRIHRLDDLTWPAPIVQVVEPTVVDSQHDPVTPPLEDMRERYRLENAEPALTETRLSELLPPPWSLVTICLSSDSDALLISRQRRGDDTIVLKLPLDRLARREGDEDLSLPYSLAAATLRNIIERSNAGTQNAKFVNTPEGRAAWWQERKELDGQLEALLGGIEDVWLGAFKSVLCDAREHRSEAFAAFKSRIERVLKRSMARAAGDRRAARFKVDDTVLQCLAALPADSREEDLEDLFYFMAESFQFSGVPLASDETDVDQVVVDFREALEELHGTKSAPKLRPHPDEHTFLVLDKHLHAFPWESLPCLRGRSVSRLPSTSFLRDRLDCAATRNQADPLHVAFDPTRAAYILNPGGDLKTTQGTFEPWLTEMTKSRDWLGVVARAPLEEEVRNALASRDLVLYFGHGGAEQYVRSQTIRNLSQCAVTMLWGCSSGLLKDQGIFDPTGTPYHYMVGGCPALVANLWDVTDKDIDKVAWSVLRRTRIAEPADEAAASLPPLSLAAAVAQSRDVCHLRYLNGAAPVVYGLPVHFRYAPERIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B573</accession>
    <name>A0A2S5B573_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_5246</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B573"/>
    <dbReference type="STRING" id="741276.A0A2S5B573"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="670"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="354"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY71885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="797" mass="90723" checksum="1AE21A758A38F787" modified="2018-07-18" version="1">MQSQSAYAERETLLHRKPTAAAAPVPSSSTPTLLEDADERRPRPDKRDDEWTDKAGKPFGLENVPEDVQPSKNKTDWIVFALVFLVAAAVRFYRIDHPSSVVFDEVHFGKFAAYYLRREYFFDVHPPLAKLILAFQGWLVGFDGQFEFENIGDSYIDNNVPYRGMRALPAILGSAIPAVVYLIMRESGYARIVGLFSASLILFDNAHVGQTRLILLDAQMIFFMALAFYSYIRFYKLRYSEFTRPWWTWMTLTGVFLSLTISCKMVGLFAFLSVGTAVAIDLWNLLDVKRGLTMQRFGRHFAARAVGLIFVPAVVYMFWFWVHFTILTRSGTGDDFMSPAFQQTLLDSPLTALAEEIRYFDTITIKHKATKAFLHSHVERYPLKYDDGRISSAGQQVTGYPFNDTNNNWIVEPTREIPASGRGRIVRHGDIITLRHVATNTTLLTHDVACTTMATNTEFTTWDGTCANEQECESRKRDTHFELLIDEGHDGQQWMTKSGYFQLVHVPTRVSMWTHNNPPLPEWAFKQQEVNGNKNIKDRTTFWFADEIIVDPTAKPDLARPKKKEPQPPPKMNFFRKFFELQILMLQHNAGLTDSHPYASGPINWPFLLNGISFWTGAAETREQVYLIGNVVSWWICIMAVSVFVGVLAADQLSQRRGLEPIPRPVRNRLHNTGGFFLISWAYHYLPFFTMSRQLFLHHYLPAHLLSALVAGVVFSFLFCGDTVNYPVSIADVKTRRRPRTRAVVTKGMKLAFVIVNGLILAGFVFLAPLTYGTPGLSPGEVQARQVLSSWTLHFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5A0</accession>
    <name>A0A2S5B5A0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5A0"/>
    <dbReference type="STRING" id="741276.A0A2S5B5A0"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000051">
        <property type="entry name" value="Probable MDR1-Mac1p interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000002">
        <property type="entry name" value="TBC1 domain family member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="254"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="697"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="882"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="913"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111866" checksum="CCEB92227A3FB703" modified="2018-07-18" version="1">MSLRKHQTKAYWRDATKEDLFREAFGLPDEEEPLGEVHAMLLMAGQEEAHLGKLYLSTSFLTFSSLDRRSCRLTLPLATIRRVEKLAPGQEGTTVGAFALALTLFHGLRIIVQLNSLRPTNDQFCANLRVRLKASLSLMKALKPFAATFFSEYFLTSDRDDDEKAAAPEDAKVGELISFDDKGKGKETQEPWTTEWGTAGGYHTGLGAIYKFPGDARKLREKSKMKLWKAYLEQFGRNLTLIRYPSFTRLVLVGLPNRLRGEIWELTCGSMFLRLQNPGVYAQILEDNKGRRSASTDDIEKDLHRSLPEYPAYQEATGIDTMRRVLTAYAWSNPALGYCQAMNLIVASFLVYMSEEQCFWCLSVLCDRLLPGYYSPSMYGTVLDQRVFEHLVSRCLPTLHEHFVRADIQLSVASLPWFLSLYISSMPMIFAFRIIDCFFLMGPKVLFQVGLAILKLNGAELLECTDDGAFIDVLKDYFATLGDSAHPNSRDSRQRQVTKFQELFVVAFREFAMVTDETITTERKRFRSEVLVSIENFAKRTALRNLKSTGRLNAEQLALAYDHFQLATLQQKEDQRLSSLANGSRSRASSSASRMTPKSPTLASSRSSLSSDSRPPREDTKMEERLERAAFGKFIADVATWARDERMVKNGLLSHIERQPKEHALIDRIFAAWDASATGSLSLQDIVLGLDTVLFNDLMQNVAWLFGIYDSDHDGYLTKDEILQVSEALLFIFRNEPGDRYLGSVSNLLQNLFEFAETTKPALPQGSTLSEDDPERPFLALATFRMCVLTDALLEGFFESDLTQSWRLDVLVPEEKPKPQTRAGGWWGGLVEAVMTDENKERFNRLADEVGKRLDIQTVEQRPSIGKLDAAAAAIEPQARDSLFSTSSARRKPITPAVSEGSVNPLSAAAMRMPAYPTSDNPWANDSPSAPSAPSVPQHDIDVQALAQQAAMQRPQFAVDEVAEDDGEDWVGADGDDGLLGQVDAMLQAEPQGSGTAGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5A2</accession>
    <name>A0A2S5B5A2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5A2"/>
    <dbReference type="STRING" id="741276.A0A2S5B5A2"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="239" mass="27266" checksum="09F4CC6125BB00C5" modified="2018-07-18" version="1">MLLNEATTLATDRVVLRPYRRWHVPRYHEWMLDPELREATASEPLSMTEENEMQQSWRLDDDKLTFIVHSRRNDAPSPTEDRAAFLAAHSDPATMLGDVNLFLHDPEPPTDDEDLVTEAPGASESPRRAEMEVMFPPTTSFPARSGLATHTLQVFLSYASAELRLPPSNFFARIGFDNEKSLGLFRKLGFVEGKRVEVFREVELVWPSAAGAETARWPWEVEPGWAFAVVEDPRDEERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5G7</accession>
    <name>A0A2S5B5G7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000062">
        <property type="protein sequence ID" value="POY72018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5G7"/>
    <dbReference type="STRING" id="741276.A0A2S5B5G7"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="58605" checksum="0F6A925FCA2B7C62" modified="2018-07-18" version="1">MAASATSQEKADPFDEKDLGAVETCENSTLPVIVSAEDDKRIRRKTDRRILAILCLVFWLQVLDKNVMGYTATVGLKTDAKLKGNEYSTLSSMAAYAQLACQPLGAFLLVRFPINRLLAILMFCWGTTLAVMAAANNFRSLAALRFVLGAFESLSMPAFTLATVTWYRRAEQPIRMAAWYCQNGTASMAGAFFVWALSHNKHPSLHLYQITFIFTGALTVLFVPVAWAFWDEKPEKAGKWLTPEDRAKAVERLKANQTASNTNKFQWSQVKELFLDPKTYLFGSLAILCNNTFGAILLQSVAGLPPKTTLLLNIPYGVLQILCILLTSWCATRFRIKSFFFAIIYLPCIIGYALLYTLPRTHDNLGPLLFGFYLTAFSFGASPLLVAWIGANTAGSTKKAGLVSIYGGNVIAPNLFAAKDAPLYLNGLKYVLILVCITLLNIGLLVLVLRWQNGLKRKQRVAHGMPADLKDVSMQHKYDENAAASNEIQELPREGSDTLGGGAVDAKVVPSQEANDDRTDRENPTFIYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B621</accession>
    <name>A0A2S5B621_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B621"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="743" mass="81203" checksum="AF46C0276FE4B92B" modified="2018-07-18" version="1">MNRPRSFVRGRRSAIRQMGRPHPAVVSRSRLFFAGLLASLVVVLMYKHASCLADLARSATSQWQPIRSNVEAARKRQSQPLDLARDDAFEPKPRRRDMTPLSRRVSTRRKRALVDPATGTAAGPVAITAALPSTDSLSQRFISTYDGFFNSLTASAEALLAEKITPELAKRAAGVPGTGISSAKEAESLQAYLDCVASTGEWVHDPRGTSLAGSRSGLTVHKQESRHAACDKRYYKASGASTSDASGSSTRVPTSEWNVRESLKWTWHASPTCEALAPSSLSRSSAARSSRSHLPSRRRLCELLARKSTLLLGDTTQYSLHDLILDWTTVRPQSCYGDLYCMQHVLCEDVLAVPEGRAHEVENWEVDDRIYHRLPLPPTMPPGGTKLQVGRAIDASSETSGRPDGDGEASSTMNDLAKRGPSIKEGDALLRYRRTDGLRPARSQTRPLYRAPPTDVREYNQQWLADARRSDLVILNKAPLPLPREGFNLTFDAWVRDFTAQSNGAVSVEERALRVVEAAREVTELVWLPELVEALKAIRAPPSPADVLTLYRGGWRQHADCAAASLGVEATARPPTSAGDGPPPHLSPPTLASLLMRRSPSSDELELQPLHIAYHNTQLVFQNHLARTVILPAFRIPFLDLETPLSIWRSGMVGSSVASPFQALLGAHGGQTVLSPARRGLRSPASGDCTRYCFPSPGLAIERFFLGSMATILEAGWAGSTEREQAWVGNGFTTLKDRVGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B690</accession>
    <name>A0A2S5B690_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Purine-cytosine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B690"/>
    <dbReference type="STRING" id="741276.A0A2S5B690"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="56216" checksum="502683076689E924" modified="2018-07-18" version="1">MSISSRSHETKDIDLEEKGGFQQDSPLEVTSQDDGIRRESSRGFLGWLWKVSKKLDSYGVEVRGVERVPENDRNHPRYTDVGTLWLSANMTIATFSLGTLGNSVFDLQATDACLVILFFNLLCTLPVALFSCWGKSTGLRQMMLGRFSFGPYAIWFPIVLNALACIGWSTINTIVGASALQAVTDTHQLPQPVGIIIISLITLVIALFGYKYVHALERYASIPVFIIFMIIFGEGGKYMHGGFGELGSGEPAAILSFGGTIAGFALGWTSLAADYTVNFPVETADWKVFACTYAGLNFPLILIECLGALMMSTFVDKPSWGARYEAGGLGGLLRAGLSPLGGFGQFLLVILALSIVTNNIPNVYSFALTVQSFHKSIQRVPRFSLCILCTAIYIALAEAGYNSFESAFDTLLVILSYWLVIYSTILVEEHYIFRRGSFKNYNLERYNDNTNLPAGWAAAFATCCGAAGTVLGYTGVLGKKVGGPFGGDIGFEMACAFSAVTYPVARYFERRLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6B8</accession>
    <name>A0A2S5B6B8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6B8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6B8"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="272" mass="30486" checksum="C695A7E3491C23CF" modified="2018-07-18" version="1">MSHDLLHEALNRHAGQLRGRDGELLSPRFERLALSGSDDENELVEVRTPMTASVAGSVESTPASSRSASPSRAGANRKKGGAGKPRRDKAKEREKAEQMRNPIDPFLRFPGEVLGRVLGDLDVRDLLAVGLVCKRWRRSQTLNYTWFLLLESYTFESPADRRQKYAGSNGVPQWRKGDAQQDWAQRFASVFAHDASETVESDHDENGLTMKEERELKWKEENEASELQGMDKNAMREFYKGLRNKKVKGKYGKGAVRTIEGDGLGDVVADPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6J6</accession>
    <name>A0A2S5B6J6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">A1 cistron-splicing factor AAR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000049">
        <property type="protein sequence ID" value="POY72397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6J6"/>
    <dbReference type="STRING" id="741276.A0A2S5B6J6"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="246"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="51327" checksum="BDF10CF6699691EB" modified="2018-07-18" version="1">MEPQRAAQAAYEQLGFFVLDGLPPSSEFGLDTLLWRTDRFKGVKFIPPGLHLFAISAAPTSTNEATPNRDSQSSVGTRHGVLRFYRGNECIADEWDNAREELKSEAVMEGGAAGLYKRPRRRRIVTASDGLPETTIASPDYLKSLDKSLAPYPQEEIAPHWPALVDFITEKTLARVVGLDESGSAHVDALSATADDAAVQAAALQVKKQTWGKPRGEETGGVEPADDADDRDAVAEVDEQSDLLQFVRFDEKRSWPRGAVGEELTRWSKDKSWQELLGELQLSFVLFSLLHNFAALGVYRSLFALICRASTLVLPQANRSPAAALPTPLLTNSALPLYASFLAAVRAQVDFLEPSFFSTQLPSLEQHLLDSLAVLVQSLSDALPHWTRIGEQDAGAEAVWNEVVRRWDALAQLSMTKFGWDLGVISGSHAPYAAQGGRVARDEGEVDLEDLEEGEDAPQIVGEDELGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6L8</accession>
    <name>A0A2S5B6L8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6L8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6L8"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="785" mass="81802" checksum="56752396BA63A017" modified="2018-07-18" version="1">MSLYGGISFKGQAKPPSASTSPAPVAAAVEPEDRKPFDSPTHANPAQPQPAQTPATDEKPKSATWSAALRFAPTARKRPNQGGLATAGARPSASALALKSAFGAAADDDDDNDEGGNANKASGKPAAHGIPSGFRIAAVGKAALTAAPEKAPPVNKWSAVSRPVQEIKPFASTSGTGSGSGSRIASPATTAADDKARPRTRTRRIIANPPPMTLDDLPLSAASTPGTDVNGFAQSTAGKKLAAQQTKKRGKKKRGGNGADDPELAFADVPYDPARPCDYSAYKTHLRVMREQRRLQREEEERQRRSRRDGSYSGSSYYSEDEDEDRDRSKENEPLNKKPRFFAPPSSYDNGPSSTSALPPPASYEPPSAPPREETGDEAYARRLALSQGNTAGAGLGARPPPPAFTPASTKEETGDEAYQRRVAMSQRREETGEEAYLRRMALSQGGPAGASAPPPVAPRFVSSSNPPFVPPPPPPGFVPPPAGFAPPGFAPASFDPSTTAAPAAFQAAAVPPPPPAFQPAGAAAPASGGNDALDAAQAKAREIAAKLSKLGGAFAAPPPAPAEAGTQAHAMNPQAPAFAPASTTAGGGAPGIGAASAEPDDRSFAERMMSRFGWEEGKGLGAQESGITSALAVHRAPATASNTKKNKKKEAEAQQPAPTGMASRSVVVDSSREQRLAEQRAQMGGDASRVVLLTNMCGRDEVDDDLPGEVAEEANKIGVVERCFVYLVPGETRDDEAVRIFLVMSGLAGGYNAVRSFDGRFFGGRTVRARFYDDRAFHAAQYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Z0</accession>
    <name>A0A2S5B6Z0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Z0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Z0"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="41"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="193"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="440" mass="45494" checksum="E6017432503773A2" modified="2018-07-18" version="1">MSALRTAALRANAARAAVPAGARSYATPSAAFSTADANGIKVASQDDGAQTSSISLVIKAGSRYEPAPGVAHVLSNSLFKATETRSQIRLVREAEALGGVLSSSLSREHLVLTAEFLKGDEAFFAEVLGDAIARAKFLPHEYTEEVVPQVQAEYEQSLRDLNVYAFDLAHQLAFRKGLGNSLFASPHVAVDQQAAVSFAKSAFTPANVAAFGSNIDSGKLAALVKDFVNLPAGGASSISTPQSQYYGGEVRVPASARVARDQLVLAFKGAARSEVDYSVLAFLLGGEPSVKWGQGASPLSKLARGSASAQAFNLAYSDAGLFGISVSAPTHEVADVATKAVAELKQVAQGVNGDALKQAVNKAKFAAAAAYETRVGQVQLVGEQVATDGQAPSLEEVFVKLDKVSAESLAKAAKAALASKPTTVAVGDTHALPYSDALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B775</accession>
    <name>A0A2S5B775_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B775"/>
    <dbReference type="STRING" id="741276.A0A2S5B775"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="474" mass="49518" checksum="A37657218116D280" modified="2018-07-18" version="1">MTAAQELPYGFSPRSSVAAEFDDVFDPIHFDEDDYALADEDDDDLHHPSASVAGTDVGFDANGAMSATGTKKSKRANFRKGPQNADKRATHNAVERKRRESLNDRFLELARVLPTTSSLKRPSKAVVISKALDYVYDTVNRERALIQENNDLRLEVDQLRASLGMPRLPPPQPLPERRMATAPTLRKAKKATNGTFSEPPQQQPVPLPTPALTDALSAAAKQEPTSPAMPTPSEPSPPTASLPPASPAFFSTLGAAPGVSATHPSPSTASVASARTPSLVFDPTSISSSVTSIPFSGLYAASPDAHSPATVGSLDARPESVSSSLSPPNYLLGAGAAASQSPFSPAALAAMHPHMQAQAAQFMQAAVHAGSQPQAFNPAAAAAAAAYINPAIMFALQQQQQHAAHLQAAQHQHHAVAAAAAAQAAQQQQLNVSEWLNGYNNAVAAQQSGMFAGVPSPPTASMSGAAHAFEGISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7D6</accession>
    <name>A0A2S5B7D6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7D6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7D6"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF1">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="269" mass="28650" checksum="FE4499C0A1375034" modified="2018-07-18" version="1">MSLPSDGLPRPAPQLPNSMLELFSMKGKVSIVTGGSGGIGFAAAEALAEMGGDIALQYRSAQGMDERAAELGKRFNVKCKAYKCDVSDYEGVQKLVEDVKSDFGRIDVFIANAGMGGSGRINELELDQWRKIQAVNYDSVFYAMKAVGPVFEAQGSGSFIATTSISAHIVNVPLDQSAYNASKAGVMHLCKSVARDWRLFARVNTISPGFFDTPMGAAPEVAETVYKYSVLGRQGLPAELKGAFLLLASQAGNYITGADYLVDGGYTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7J4</accession>
    <name>A0A2S5B7J4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7J4"/>
    <dbReference type="STRING" id="741276.A0A2S5B7J4"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000022">
        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1048"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121289" checksum="B74A87CABD9B36DC" modified="2018-07-18" version="1">MAMSDEDAGEAILDFNQPLDVTLLDQVAQVFLTGSGTQQQQASTVLAQFQEHPDAWQRVPAILETSSNGQTKYIALQIMDRLIKTRWKVLPEEQRSGIRNFVVQVIVKTSSDDATMRREKSFLNKLNLILVQILKQEWPHNWPTFIPEIVSSSQANVSICENNMVILRLLSEEIFEYSAEQMTTAKTKALKAQICQEFAEVFSLCVEVLEKADKASLIKVTLEAMLRFLNWIPLGYIFETPVIDHLIGRFLEVPEFRNVTLKCLSEIGGLQIGPEYNQKFIILFNMVMTSVNKMIPPSTDIAGAYENSSDSDQELVLNLALFLTNFLSSHVTILETPSHRDVLLNAHLYLIKISQVEEREIFKICLEYWAKLVADLYDEMQKFPGGELAANPLLNLGGFGGPGAGGAQPGRRGIYTEVLSNLRLVMVERMAKPEEVLIVENDEGEIVREFLKDTDTVVLYKSMREVLVYLTHLDVVDTEMIMTEKLSKQVDGSEWSWANLNTLCWAIGSISGAMNEETEKRFLVTVIKDLLGLTEMKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFAHETHEGVQDMACDTFIKIAQKCRRHFVMQQSGESEPFIDEILRNLQRITSDLSPLQIHTFYEAVGYMISAQPNKPQQEQLIANLMSAPNAAWDSLMAQAAQSGTEILSDPENIKILSNILKTNTAACSSIGTFFLPQLARIYMDLLGLYTAVSGIISATTAEQGLIATKTPKVRGLRTIKKEVLKLVGETYIRKAEDLEQVNRDLVPPLLEAILGDYKQNIPAARDAEVLSTSVTIVSRLGPLMTDKIPAVLDAVFECTLAMINQDLTEFPEHRVAFFKLLRVINLNCFDALLKLPPQQFKLIMDSIVWATKHTMRDIGDLGLMICVELIDNVVAAGPATSNGFFQAYYLALLQDMFFVLTDADHKSGFKSTALVLARLFKLVEQGDIQVPLDPSAPSNPAFVADYTANLLKSAFPHLQMTQITAFVAALREQWGDFNKFRITLRDFLISLREFQGEEATEIFQEEKEEEAKRKKEEEQARAAAVPGMLKPDQMAGDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7L2</accession>
    <name>A0A2S5B7L2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7L2"/>
    <dbReference type="STRING" id="741276.A0A2S5B7L2"/>
    <dbReference type="OrthoDB" id="6347512at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="739" mass="80445" checksum="7F9A0176F2A74FEB" modified="2018-07-18" version="1">MSDSPLAADILQRIVGLLQASRRGAGRAVGPSDDVLSSNIEELHKQACLSGLDASEVELAFQLALGGGMLLACVLPRDVVSTKAVLAIVSASGPSRGAPSAGKDQVDFGTQRFALFQLATLLRNQSVSPVARTALQSLYTVLEAGLVYCTLREPTAAILAELGEARDVQLHRLDKLQERVLPPGESAQAESIERLLDDYRSHDVQPQPVYPPSGADVAVKPDEEPAAFLQWSSDYLRLRERLEILPSVLHERTLEPSWLDEHTLPQDPLRLLDAEACRAKTPRTRPKDLSEMGATWANILHVGFENDDNHTVSYQHRCSYHTNVQLLRHLHHGQSADSPDAVAGLLRKMRDVCSLGGELLEGNEPFLADYLTKWDGLSHQHLVFELIALLKPFDIAQLENHYLQPLRTLSRAASATEQFLTDLVGCLKELVMGWASRDDWAIDASRITIFGALDSDYNYVESLQHLLQFAGEVIESAVLRFSRSLVLRAAALDFYELALDLPLSLGLPVLTLPSPTLTYVCLLSTEAASLSRICGIIGRRVAIQQASSHALTGPNSALDKESEYSARLVVSLNRIIVDFVNTLWQKKLLKSQGQAEAFNLNRWASLCGFSAASVTAKLTIATSSDEIEVLRGYVQARSAAGSGSLGLTTHPALAKLARTCLDVLARQSGRSATVVEGAVTAASLKQAAEGPEAIYITWSDFRPRFLEWGKALGLDGLADLLFASLASLLAFRVSQESQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7U0</accession>
    <name>A0A2S5B7U0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BMF94_4200</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7U0"/>
    <dbReference type="STRING" id="741276.A0A2S5B7U0"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000002">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="23">
        <location>
            <begin position="212"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="22">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="POY72791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="277" mass="29331" checksum="0D8F6B1980E7D60C" modified="2018-07-18" version="1">MSLTRRAVNLAPTATQLASGVPCARALNLRVPGKPAEHGHGGSSHGHGVAAGRGDKAPRWAARNSVGLSGVKVHAKVNASPLASYQPRYLSTSAKALDAASQVPDFGKYTKSTSQDSSRAFSYFMVGSMGLVTAAGAKSTVTDFLTNMSASSDVLALAKVEVDLSTIPEGKNVIIKWRGKPVFIRHRTAGEIEEANKVDISSLRDPQKDSDRVKKPEWLVMLGVCTHLGCVPIGEAGDYGGWYCPCSGRARRGPAPLNLEVPEYAFEGDSEDKLIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B813</accession>
    <name>A0A2S5B813_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BMF94_4079</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B813"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="218"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="366"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="644"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="744"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="826"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="873"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1254"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1032"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="POY72918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1343" mass="147226" checksum="84F5F77AD6B817F9" modified="2018-07-18" version="1">MPPKGMSKVALARAARAKAAAAAAPPTPPAAPAALPDTAAATETATNGQGTSLDLGPVASTSTSGTPPDSAPANDLFPAAKALPTEPMDLDETQETGEGDTEMVDVEGAEGGKKVLPTGDPTTNSSAGGGVNGKADSERKREKGKAKQQDDVPVQKANGRGGAGEMKSMQDVGRDPRHLAEGLEALGQENYKGKALTDPIKSVTDKWDLLPAFLAVKGLVKQHIDSFNYFVDVELQAILRANARITSDVDPNFYLEYTDIRVGAPERPDENAINPSIAPHECRLRDLSYSAPVYVSIKYTRGRQEIVSKGIRIGRLPIMLRSNKCVLTGKNKAQLAAMNECPLDPGGYFVVKGTEKVILVQEQLSKNRIIVETEPKKGLVQASVTSSTHERKSKTYVMTKHGKIYLKHNSIHEDIPIAVVLRALGVVSAREIVQLVCGNDDDYRAAFAINIEELDDLKNKSGQQIFVQTQQQALDYIGSRVKVIRKTPGTAGSSGFGAGWAPRRPASEEALEVLATVVLAHVPVEDLNLRPKAIYIANMARRVLLAMQDPKNVDDRDYVGNKRLELAGQLLSLLFEDLFKKFNHDLKINIDKILRKANRATEFDALKQFQLHGDGITQGFVRAISTGNWSLKRFKMERAGITHVLSRLSFISALGMMTRISSQFEKTRKVSGPRALQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDVEEEPIWNMCFLIGVEDINVLDGTEIYAEGHLVVYLNGNVLGLTRCGPRFIRTFRQLRRAGRINEFVSIYVNLQQQAIHIASDGGRICRPLIIVENAQSKVKELHMRMLRDKVMTFDDFLRKGLIEYLDVNEENDAYIALYENELKPETTHLEIEPFTLLGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAHNQLNRIDTLLYLMVYPQTPMCRTRTIELIGYDQLPAGQNAMVAVMSYSGYDIEDALILNRASVDRGFGRCQVFRKAVTMLKRYPNGLYDRLADPPKGENGEVMPRYGILDLDGLAHVGEQVNPGQIYINKQTPSGAHDNQLPDGAGGASGANAPASTWKNAGMAYRGAIPGYIDKVLLTDTDSDSTLVKVLLRQTRRPELGDKFSSRHGQKGVCGLIVPQEDMPFNDQGICPDIIMNPHGFPSRMTVGKMLELLSGKAGVLKGKFEYGTAFGGSKAEDMSRVLIENGYSYAGKDYLTSGITGQPLECYVYMGPIYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIAHGASQLLLERLMVSSDAFKVDICGSCGFMGYNGWCMRCKTSKAVVKLMIPYAAKLLFQELLAMGIAPRLVLEDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B842</accession>
    <name>A0A2S5B842_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B842"/>
    <dbReference type="STRING" id="741276.A0A2S5B842"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="311"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="885" mass="94212" checksum="BD51BCED0D85F29F" modified="2018-07-18" version="1">MLIRSRRQKHICVIPIRGDPCKACQSRKRPCTFDDPPTTRVRKPKTAVESSEEPEQRTRIDADVTLIPDEAGPSQQPSRKRPRSRGSFFSSSASDSGTFSLTGSILDLVRSSRDAPRIDDAATPSSLFVPGEGSRTEMSYISPGTFADLTFSTADSHRSTFPGDVVFRQVSNDPTKPVFFISGPTLMYGYIAPESERLWQSACSVLSAGAPQRLIEIYLKRSQPAIPILDMSTFAEADPAILGSKGVSYALLTGLVAHATSYVHEIRSVHKHLWRQVVLPLEDEFRKPTFQTIQTAIIILSSRPAINVAQNHIAMGRVVSAAHLLGLHLDPTSWRVPGSERALRKRLWWTILIHDKMRALWFGRPSTISTSDWSVPMPTLSDLDAQDTTDTVQRGSAESYLAWCQMTSLIDCLITDFYTVRACSTARSLDERLALLEGHGMRLRGFEAELSSELRTLPSSESRPEVPAASGVRSFQLCKLGVEMSLLRLTTASFEHPTSAQIVDAARATVTFSHALVEFLENLLPAEFDMFWAPYCSFIISAAGALMLRTAIAVGSLDATLRNTTGVLFARLVVTLTSSHHAAHWDVASLALDRIATLLRSLDGRLPELTPLLQLFGAPNHVTTISELPSGERAHPLASPPYAPSPLPHQRPMPTRAFSDLAPSTTSPSQHAPFLSPRNPAPTPLPFLGSGTGAAMPSFPPMPTTPSPSSTNPTFLPPPSRDGANGPTSASTPWAATTTTGAPFGSSAGDGVGTVATPLGSDVMQPLDPLWWMNTDILSLPDHFGTLPDLFDQAIGFIGGGGSGSGGLDQTTEGAAVGATAQQPGQGQDAASMSLEAGGGVSAVGSSGGGGGGAPAGAAGTQTPIGPNGLFDLRSFLEGGGISTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B872</accession>
    <name>A0A2S5B872_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B872"/>
    <dbReference type="STRING" id="741276.A0A2S5B872"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="308"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="367" mass="40075" checksum="20C747CEF944D7DB" modified="2018-07-18" version="1">MNKDDLPPRTTPDYAKYQRDIFLEGAETGSLPEFNTDPDLVEEKAKETLSKGGWLYANSNAGVSWTHRANREAFYQWRIIPRMLVDTNQRDMSCTFKLGNQQYTFDAPIGFAPIGINKIYHPKGEFNSARVAGELNLCYALSTAGSQPISEVARVHDEGAAQGGRPNKHKNGAKGRWFQLYWPHNDDLTVSLLQDAHNSSYSACVLTLDTWQLAWRHGDIASANKWKEISGGKPFVLKGIQSVGDAKRAAATEGIDGIVVSNHAGRQVDGAIGSLDALADIVDAGVGDKLTIMFDSALALGAKFVFCGRPWVYGMSINGEAGVRHVMKALLADFDLLMNVGGFRNLGEITRDSIRHIPHASLGGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8E3</accession>
    <name>A0A2S5B8E3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Phospholipid-translocating ATPase</fullName>
            <ecNumber evidence="5">3.6.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.1" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8E3"/>
    <dbReference type="STRING" id="741276.A0A2S5B8E3"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="4">
        <location>
            <begin position="148"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="3">
        <location>
            <begin position="275"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="493" mass="52598" checksum="AF80CE0DE28C4601" modified="2018-07-18" version="1">MRNGGGGGKSGYGYAGSEAGTAQSVTDGGGDAHSEADSLLGGIEPDPNSRGTRRSGRTARGRRGEAAIPVGLGGRGESDGDFDAGWTNGLEAEEEEIGLLASGRLDRDRPPTTGGPSPPGKPTRTPSSFKRFFALSAPPSSQPRTIVLNEPPSKRKKAPHPPNIVKNQKYNLATFLPLVLYEQFKFFYNLYFLLVALSQFVPALRIGFLATYIVPLAFVLAVTIGKEAYDDYVRYLRDRSANSAKYSVLTSAAAPSPHSHHASSSNSSPAPLRPTPSADLRVGDLVHLDKNDRVPADVLLLRTSDPSGTCFVRTDQLDGETDWKLRVAVEKTQALATDADLLQVGGEAYADPPTKDIHTFVGNITLRSWPTPAASGDDAASQSQDGPIAASNGDVVEPLTAENMLWANTVLAAGSAVGVVVYTGRETRAVMNTSQPGTKVGLLDHEINRLAKILCAVTFVLSVVLVALNGFRGHWWVYVFRFLILFSSIIPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8F7</accession>
    <name>A0A2S5B8F7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8F7"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF1">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="167" mass="18867" checksum="0C4B5713721550D1" modified="2018-07-18" version="1">MPHSLVVEGDKVIEKSADGEIIKTSDYNHVIGGYKATLKKANVSEEAKAEARALLHDLEKAHKPFEESGEAEEHYSSTRHRRKSVSQPSPEKEETEGAEQPHHKPHRYEEPGDELPLPHEGETHEEIVHRHRVAGTFKGILHRQDASEETKAHARDCLDKMGVSYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8L3</accession>
    <name>A0A2S5B8L3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8L3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="248" mass="27722" checksum="5B2B3DC734568E93" modified="2018-07-18" version="1">MNKIIYLTRHAQAYHNVAEDWSIPDAELTPLGRDQSAALRKDTERTFQRHVDLIVSSPLRRPMQTALIGCAPLIERLNGQGKPMILLPELQEVNDLPCDTGSARKDLESNPEFASLDFSPLEPSPLPSHWSSAPTWTSKRGLFDPNRCQERARWVRRWLRDETHPDEKHVVVVAHGDILRVIADGHRSDKPWANAEVRAFRFKAVDDHDAVLVAATEIEITASGPDSASEATVAKEGSDEPTSSELKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8L7</accession>
    <name>A0A2S5B8L7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromate ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000041">
        <property type="protein sequence ID" value="POY73116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8L7"/>
    <dbReference type="STRING" id="741276.A0A2S5B8L7"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="56959" checksum="81C52833BD45578B" modified="2018-07-18" version="1">MPTSSGAAESDRRSIPLAARLVDTVREYWHLGFTAFGGPGVHVVILRKKLVPKWVDETTFADLFSLGNALPGPGSTQLAFSLAVVRNGTLAGFLAFLIWSLPGAIGMAALAAGVRKFPDRLPPIVLALLTGLNAAAVGLIALAAYQLAQTAISDRVTRALVLASASFGICYHAPWMYPVLVAVGGLTTLLFDFRGRVLGLLPRVRQRRRPLHGVDSDRDPAPRRGDDAIELESIPRRRTEAGRDDDNDDLKPVAPDVDSASTLRHRNGSSTSTTAATTSAPPVNASASVERSTVLMVLNRKVAFTLGAGFVVYLVSIIVVRSKLAHPPRALDFFTNMVIGGTIIFGGGPVVIPLLRQYTVQPGWVESRDFLLGFAILQAFPGPNFNFAVYLGVLALPHNPVLGALLGWIGIFSPGIILKLALLPLYHTWRKHAVAISVLRGLNAAAVGLVYTAVWQLFLVGYIYTPVTGQVATTSSASGPLTSDPFWGVVASCAFVATQWYKSPPAVTIVGGALAGLAWFGVVGPAGVERQQLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8P3</accession>
    <name>A0A2S5B8P3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8P3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="526" mass="57453" checksum="D6F58CE44C63BEB9" modified="2018-07-18" version="1">MRNSERAQVFRTQRSAAASLFIFLLFARPQEQATSWLRNSMSSVASLMDRWKHDLGLNAGRSTTRFQPARSQPFLAPEARDTLQPPSHAPFKSKRACSEMRDSERATQEADSSVEEGEIRPDSHSVKRAKQQTGRVQQGSATIRAAQATSDSALASRADLPSAQSSKSNLQRFFNWNQATDGSSEHSGKRRRFLPPAGESTSSQKIPSMRNQLKRIAEPCYDSVYARQEALDGTISSTELVQTHREQAAAADPHHDRNLWRPAFLTGRSPDQLMRHRLPSSSDGSEPFRLAVQITVQRSANAEQSLAPKKEVETIVIDDNESDACSTPTPTPAAATAGTVATPAEVPIDSPVSRSTVRFSASVSDLVSPSGVVQITPPGPPPPFLTGANSLAVSRPRGASAVPRAGSTYTGALNPLEAAAASTGGPETAPMTNLTKKQRKRRAARKAAQVRAAESAIAEAVAKERESLQGSLRAVKRLEKLKWTVEEREHMDKMMTEQPRWIKSHKATGRKLRRFVEILKRRTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Q8</accession>
    <name>A0A2S5B8Q8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Actin-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Q8"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Q8"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000122">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="435"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="84338" checksum="9176A2A900ED0DCC" modified="2018-07-18" version="1">MAVPAAVERDRSVYPIPELQPVVAAPPAATDYSQFANADTVLCLDNGATTLRAGWSREQDPRFAIDNLVSKYRDRKSNRSVLLAGSEVYVDATSRAHVRAPHEADVVTSPDVMENILDYVLLKLGVDSDGLQNPVALTETLCNPVYSRSLMSEILFEGYSAPSVSYSVDSLMSLYANSPNPASADALIISSSTASTHVIPVLNGQAVMTNAKKLNWGGSQAAEYLLKLMQLKYPAFPGRLSSYQSGVMYRDHSYHAVPSYASHLARLASSPQVIVAEDRTIQFPFVAGMGAQEKTAADLEAQQKRREEATKRLKEQAARQRQEKLERQQEELVAFTELHEARGTVSKLEYDQKLRAAGFSSLPDLEDYLKKLEKSLTRARNRELGIDESENKEGLRIIQEPPSFPLIDVPDHQLNEEDLKEKRKQKLMKAGYDARIRLKAEKDQERRRVEEERRRDEELRLNDFPKWLQGLREQHEDILEKIKERKKLKEQLSDRKSLAAQNRMKSIAGLAADEKAGRKRKRTEQDDGFGQNDADWAVYKEIGTGDDSEDEEDEQEALKKVESRLLEHDPKFTLDDTAERRAMRKHQLLNAFIRGLAPDDPLDTYDPESPEHNSQLHVNIERTRVPEVIWQPHMAGLDQAGLTEIIEHVLKGFTESERQRLTQNVFVTGGNTLVPNFDARLRSSLQPSLPVGQALNIVRSYDVQNDAWRGLAKWSTTAEGQQARITRADYDERGKDWYAGHAWGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B979</accession>
    <name>A0A2S5B979_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B979"/>
    <dbReference type="STRING" id="741276.A0A2S5B979"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="27857" checksum="4E8F453BBF7DFBEA" modified="2018-07-18" version="1">MASAQAPNADDILGQHRFMTPGAGSSSSPQQSAPFAPTASSILAGTSLDAAALHPLAGVVDNKELDYLLLEDDKLSSVAGGKTVLPSRGWGDELCYGTGSTYLAGLGLGGAWGFVEGFRRPIAAPRAPAAPVAAAAGGAAPVAEAIGAQAAAFAKQAAPVAATAAEGGAAATAATTAARPATQRVSGRLRWNNVLNQVTRRGTSMGNSAGVLALIYNGINSTVDVYRGHVHDVYGSMGAAALTGLIWRSTAGVKSMVVTSGLLTAGAAGWSWFKLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9A3</accession>
    <name>A0A2S5B9A3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9A3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25380" checksum="EC7576D6ACC53FB9" modified="2018-07-18" version="1">MSVSSVTLTEASASIAYSFKLVWEFAANLSCLSLDRDAFERKLKQNPMQGRYRLDFKDDELSGELRRLCCLQSDLSAGDLGERVTVDLRLEWVSNGEEVTLAAKSFGPDIQPRKRTTPGGGAYDGWALDVDLAAIGAGHPSFHAVVDTVQSYRFTAKIAQKPPRSQNETEIGDFETATRLAGINLDPLPSDICFMFPKPGVDRPLELWTSSALLSTESPYFQDMLTSECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9D4</accession>
    <name>A0A2S5B9D4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_3719</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9D4"/>
    <dbReference type="STRING" id="741276.A0A2S5B9D4"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="15">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="926"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="130"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="493"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="695"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="873"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="955"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY73382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1200" mass="124171" checksum="B2551D446DE1FB80" modified="2018-07-18" version="1">MTMPASLRFRRKRASVLSALYSPPTPTPSPITFYPLPLDSPSLALHSVFSWTDSDAHTNVDVDFHSILPLGTAKTLRSIASRVSLRLSPATASPRTPSHRSLRSPSFLVPESPRSIRSIRSRLSVQRLRPSVSLPMLSGTGTAPRSAKRPRTGAEPVTSLPSKQSTSSRPGSSSGPAGGLGAGWGSGNGATGYAQQNSGGSSFAQQQQPRAYGDAMPSTAPLNYRPVRTAPQPPLASLSTSSGPLGGSGNYLDEADHRDMYDSPVEGSGSGSGSHHGHRTSFGAGGGATRPSYSTSATSGRPPIFPSGPSSSAAAGSSFQPSRPAPPLPHAAGSYSSSTSHTPTTSPGRYHSPLPSMTGNGNGSGDSLSQHDDGVYGYGGYGSGPARRQASNNSGAKLGSQPSLRDLSDALPPSSSVTGASSSSADAFGSTSSYGHHGARVATPNSSASSLVSTGGNGSNSNNQHAHSYSVAPQSYNLLTDPATAAAAGLSVGANHENGHADPATFAGYTPASGPYAGGGGGASNGPPQTPGPTSGYAGDSAQRWSGDKESQSSTPSTASSAAAAAAAAAASGGGGNGGSGYASGTVKEGKRSKGFGSFFADVFSTTGGGGRKAQISTPYDPVHLTHVGFNSSTGEFTGLPKEWQQLLQNAGVSREEQAAHPQAVAEIVAFYQDATKGLTAPPGAEQDDVWNKFRQAQTGTAPSPAPAPAPQQGPPRAGMQSFEQPRQAPLPPPPGSGPYRQAPAPPGATSPAMAPRPGVSHQASTGGLDRSRDLRYDSRDRIPSGSPAQSQSSSPASHQQPYGVQRSQSARVSPIPSPNAPPSPTRPKVGGGAHPGLDRAQSHRVAPAPPQRAAPAKPLALLPAASSGAGASAKTALVKKPSQSGGGDAAGLQQPRRREPKNRKDPNIIERLQAICSDADPTKLYRNLVKIGQGASGGVYTAYQVGTNLSVAIKQMNLEQQPKQDLIINEILVMKESRHPNIVNFIDSFLVRGDLWVCMEYMEGGSLTDVVTANIMSEGQIAAVSREVLQGLKHLHEHGVIHRDIKSDNVLLSMNGDIKLTDFGFCAQIKGDNNAKRTTMVGTPYWMAPEVVTRKEYGSKVDIWSLGIMAIEMIEGEPPYLNEQPLRALYLIATNGSPTINNPEQLSVVFRDFLAVALEVDTEKRPAAAELLRHAFLAKAQPLTTLTPLIKAAREAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9P5</accession>
    <name>A0A2S5B9P5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_3434</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B9P5"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1043"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1079"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1343"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1731"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1764"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1792"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="15">
        <location>
            <begin position="32"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="16">
        <location>
            <begin position="2006"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="813"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY73497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2063" mass="225574" checksum="B6F1CE378609E062" modified="2018-07-18" version="1">MPGGTAGDLAAMADLAQLASQSGTTAGRRNSTSLTNSSVVAVPSPDALTHAIAQRYRVDLTATYLGHSNLIVVNPLEPKSDTSEASKAEYEDRVYRIGHEDVSNADVNPHAYDLACRVYWAARRSGRSQSIVYSGLSGAGASSQQHLVTAQLLRLSTSGKKDTRLAEQVSALETILTSFGCAKTTSNPSATRYSSLLELHLNAQGRLSGAKVLAYGLDRTRFAKIPKGERSFHALYQLVAGASREERHAYHLLDDPAEYALFRKSTTFRLPPGVPLADDSIAFEDLRTAFKVLGFKPKHVASIYRVLSAILLLGNLDFAEHPEDAYDYQSESAWVTNVEVLEQVADLLGVASADLERSLTNRVRWVRKEMMATILRADGADQQRDSLMAALYSIVFAFVVETANHKLFPGDDAIAAMQKDGGTSILQFSQPGFTNHSSARPGSRSSVLIQALNGYDDFVHNYQTELARHFTTEQAFDGDAGVAARAQEDGLRVTDVLPADNGAGRIELLRGGRIGGKADKKPGGILGGMAKTCASLRRGIQPEQADTDLVAGMRDHFAAHPSFVANPSGPGARTAFAIMHWGGQMVAYDAYRCVETDCDALDPEHVAMLRLSGDPFVAKLVSGPGLAAEVHPIDDATLVAAQVSSMPLRRPSPVQTVQSFTPADCEQRDYTAPLLDPLAIYPVSTQINATTSQILGSILARTQQWNLIALLPNATATPRQVDARLLKAQVAALQLPELVARRNTVDWACDVTYEDFVDRHGLGISGQETARDSVASYAGDFGLDQSRGDFALGTSRLWLSWSAWRALEDRLRSDEPAEHRDRARETATQARGGHSADTSPPNGKKDSSDGSAAEGERGMLGYLPELGPSRSTVNVGYTEGGFRQSHGPHSGSVDDLLYDGGATPGSPNAPMFDYSDAAAQPGRTQSGFFSEYNAPAESYGLRPPHAPYMQEQSSGGPGSGFPSMGSFGGYGAGGGGLRGRDSEVWGVQQGDAAAPAPAVPFTPAGARMAGANKEAGVLDRDGNPQEGEGKAIAEVPTSRGRRIWVAIVWALTWWVPTPCLTYVGRMKRPDVRMAWREKLALCLLIAFSCGLVIFYIIVFGRLLCPNYNNAWNVKELGYHSGTTDYWVGVRGNVYDLTKYYKIQHSDIQGQPVTSTDMLQLGGLDLTHYFPIPLTTACPDLVTDGSLSLQYENFTAEVPTAVHTSGQLQPATGSALYQSNWYFDTFLPKMRKYHKGPLVYSKGDISKEANAAGRQWAIVNGSVYDLTDYFYTYTLLNDKSYQFLNDSIANVWTAQPGTDITGAIKELGLDAPTLKTNMDCIQTLFYVGETDFRETPRCQVQPNLLLAFSVLIMLTILVKFLAALQFGSKRLPELRDKFVICQVPCYTEGEESLRKTIDSLATLNYDDRRKLLFIICDGMIVGSGNDRPTPRIVLDILGVDQTIEPDPLMYKAVAEGSKQLNYGKVWSGLYEVEGHVVPYIVIAKVGRPSERSRPGNRGKRDSQILAMRFLNRVHFDAEMYPLELEMYHQVKNIIGVDPQFYEFMFVIDADTSVEADSLNRLVAAATDDKQIIGICGETRLENEQVSWWTMIQVYEYFISHHMAKAFESLFGSVTCLPGCFTLLRIRSADKGKPLLVSSLIIDDYSDGNLDTLHKKNLLALGEDRYLTTLILKHFPTYKTKFIADAKAQTVAPHNWGILLSQRRRWINSTVHNLAELMFLPNMCGFCCFSMRFVVFIDLLGTIILPATFVYMIYLIVTVATGTGEIPMIAIIMIAAVYGLQAIIFLLKRQWQFIGWLIIYLLAYPVYSFLLPVYSFWRFDDFTWGNTRVVVGEGRSKKVLQAEEEAFDESTIPLARFSEYEAALAEEALDSRSEKTRSEAGFSLATRVPPMYGDMSHARQGSRMSMPMQSQVFGYGPGAGGPGSVVGSEFGYPASVHPYMPPATLQSQMSLVGYGGAMGAPQLPMSALPRRQSGMSAFTYGGGGAAPSVFSMNPFANPPAPTASDDPNPSDEVLVSTLQAFLATQDLMQLSKRKAREGLAALFPRADLSGRKDWINEQIDRLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9W8</accession>
    <name>A0A2S5B9W8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3107</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9W8"/>
    <dbReference type="STRING" id="741276.A0A2S5B9W8"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="87" mass="9255" checksum="16C9BA54FE882879" modified="2018-07-18" version="1">MSRPLVSSSLATCCSVLSVFGFLILGALGVAFNANVEVLMGKTSSPHDGHAVAVNCWFASLIYLAFAIFCACQVGVNRRYQRGAVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA11</accession>
    <name>A0A2S5BA11_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA11"/>
    <dbReference type="STRING" id="741276.A0A2S5BA11"/>
    <dbReference type="OrthoDB" id="2526784at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="634" mass="68320" checksum="C2ADEBAEC5693D71" modified="2018-07-18" version="1">MQPYQPGHVRRRSSSSAPSSSSLRLPPLKLPIPPPSSPRLGTAVQHRRALIRTALLGAVAFATLAAFLLLPQQCITVPADIVLPAAGPSTAARKPSLHEAAMVPPKRPRPHQAAKIQHQAEAEVVMEPSAGAGTAEPPVKERPSKLPVCEKSAVFRFAGLHGFGSEVTLMYRMAAVASHFGYEVFLDDARWNYGTWLDYFRPLALPSSSTGISTALPTVTRCSMPKEGTKRAKVVLTADELRSLSGSLATDAPFTPRWTARSHVLWSTRDMDGLDLTYLHLFTNSSDLETLRRADLELAADAAPLFLTPEQTLPPAYEGAFSQSSGIAGRAWQLDEGLLQAVEGMRSAIGVSGDLPQDGIGAPTLHPSDLVIALHVRLGDKFLEIDRVKGGHATAETTDHDATPGLTDELVAAYYAAATDSVHSLAGLSRRDDDESTAIEPRWNVASGGDAHASEDVAAPNDRPLLVLMSDDPTAVDVFRGHALAKWFRIKSTVEVGAAVSPGNEPTGGVSEGKPSRAKRLRRSHPDPIPAGFNEIEFNRLPLATRIENTRVFVRDLTFLARTADALVITGSSNVGRLLMMLFEAQGKAAMRRNEVADERGPGEPIGGDGFARPPARREMRSLDTRWFPTARYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA68</accession>
    <name>A0A2S5BA68_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA68"/>
    <dbReference type="STRING" id="741276.A0A2S5BA68"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38235" checksum="E07949446371A10C" modified="2018-07-18" version="1">MIDNKGRKAYVTLLTNERYLAGLLLLDHTMKVVGTRHPLVVLTTASFPERHLNLLKTLGIECRVVGLLEPKGEVKLIAERFRDTWSKLQAFALEDYERVVLLDCDMTLFENIDHLLDDEDILPGSDWIAASHVCACNPLDEDWYLPDCKPENCSFTYAESQPNFAPPPAALLSTKRTWGLLNSGLVVLSPSKALHDRIVHHLHTSPTVATMALPDQDLLGEVFEGRWTPLPWRMNALKTFRWVHPKLWFVEREGGARVEGRERNQLQGVGHGIAVLHYIVEKPWLEVLPADSRDAETHRWWWADWRQMLAAWLEDANLHKHVASVEKLVVKGSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAK4</accession>
    <name>A0A2S5BAK4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAK4"/>
    <dbReference type="OrthoDB" id="10255344at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="447" mass="49101" checksum="3DB70477E2BD26D4" modified="2018-07-18" version="1">MAASRRGSVTSRRGGSNSHLALLSSSRKPFALASAPPGSEDDSDDHSEVCTGRSLATRRHQRIDGPRIARSLVAAVAAWPAPDATPLLRSLALVGRAYREAAQVELFRHLTIGNSEQLRRCVSVLAKNATLGRAVHDLTLRPRGGDAKSRDRVLKDARALLHCLRNLRKLDEELFKGDFDVTDLDKDYPLGSASTIRLHSFRSRAAWWEIGAIHALLTSQSELEVIDVGGAIVDREWAGARLSEEAIKPSSRLRQLCVSQILHEDTLGVLLRVCGGPEGRLTDVALGFQSIDRDTPRASITAAFRSVRDTVRQLTISAPLEATEDLSGFLDEVVAELPALEVLEWNEGADALRVPIASSRFLDHLPRTLKELRGRSLVSLSTSKVLAWLESDELGSDLKRIDLDWANGRGDEEGREPWYRERHIARIQDAAEHVGIECRLSKGDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAQ6</accession>
    <name>A0A2S5BAQ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3352</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAQ6"/>
    <dbReference type="STRING" id="741276.A0A2S5BAQ6"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="52533" checksum="3271536C3303D2B4" modified="2018-07-18" version="1">MPSIAGAVQEALDFVREWYVRAIRQGDDAALATLAKVLSRVELERIVHAASPGSVTGSSTFERSTPGDFHRLAELRYLPTRCRAAGGSGPPARITSSGHWRPFRRIVSYSTMGPLERGYNLDLPGDELVLRPPLDLEWLGFTYTAPGPVWCTQWCGFTVTTEHLDDSLYQPEMDSDAFYIVTLIQQGSYRAALAAYSELASPSETLSLYAARSHLALSPPDTQSALSLLSSLPPTLDTRAVSALATYLAGETEQAVGDLEELLAELGEQGLEQDGQGEGRLVRAVVGTVWILEGDEQRREEGVEVLREAVELGHDQECLGLLSHLYISLNLAPLSTSLLTSPSTTAITSDSLLSQLLIARSHLATGPTQKYQDAYYVFEEIKNMQGGRGEGVLSGVGVAQATLERWEEARDAVNEGLEMNPTHPTLLANAVALALHTGKTQAQADELLAQLRSADAHHPLVQDLEAKSALFDDAAAQFQPSVAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAT6</accession>
    <name>A0A2S5BAT6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAT6"/>
    <dbReference type="STRING" id="741276.A0A2S5BAT6"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="10">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="305" mass="32360" checksum="55A1624584D4B101" modified="2018-07-18" version="1">MVNASSTTDAGFDFGNTVRNAHLGGKLALPKATSTGTTIVGVVYDQGIVLGADTRATEGPIIADKNCEKIHYISEHIRCCGAGTAADTEFTTNMISSNIRLHQLSTGRPPLVATAMTMLKQYLFQYQGQVGAALVLGGIDPTGPHLYTVAPHGSTDKLPYVTMGSGSLAAMAVFETHWRPNLDRQAAIDVVAAAIEAGIYNDLGSGSNVDVCVIEGEVTPDGKYTGQAKTDYLRNYRKPMDKVQKERNYKWRRGVTAYTREQVTQFVVAHEEVIQPVVAGGIADAPLGSGAGAAQPPSTSMQIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAU7</accession>
    <name>A0A2S5BAU7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAU7"/>
    <dbReference type="STRING" id="741276.A0A2S5BAU7"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17190" checksum="269A9F22CE6A0595" modified="2018-07-18" version="1">MHSEAQTEEMGAYSRTKKVARLTFAVFSAFASYGHRLESLPNKASSMTAIFNFESLLLVILLVICTCTYARATAPGLVDRNREGESMWSCKRETQQASQNADAGTLARQCHADASHSAPTSRRFLGVFFKCARIGERLSPYVALACIIMGFRILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB48</accession>
    <name>A0A2S5BB48_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_2798</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY73987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB48"/>
    <dbReference type="STRING" id="741276.A0A2S5BB48"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="13">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="12">
        <location>
            <begin position="237"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="478"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY73987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="542" mass="61672" checksum="6E8DDB29FDF68B7A" modified="2018-07-18" version="1">MATTSSHSLAGLAADHRPYLLFGVQGPLEQFRLPEIDSVLQLFQIPHSWPTSPDPLRPYTLIGLRNDDDARKLGSRLVSVKHVWEYWASADSYHQVHDVVQSQECRAKWEPYALDEKCTWKFTTAGHNRTLALPQQVARINRFSYMAFLGPIDLKHPDLEVGLFEEYDENKEWGNKVREARRQLGDEQFEALHRDKGKEKLVESGLIDEEESLRAVWLGRKICDTSRHLIDVFDLKKRAYIGTTSMESEASLLMANQALAAPGKWIYDPFAGTGSMLLTASAFGACTFGSDIDGRQIRGKKTGIRHSAEQYGVWNRILDCYTFDMTQHPWRTGELFDAIVTDPPYGVRAGAKRLGRDEGEREVQPQVIAGRESEGYHHQFHDYVPPSVGWPMEEVISTLITYALYLLRPGGRLVFFLPTDSAVYEDIDIPVVPGLKTISNSPQQFGKWARRLITMEKTTETEGEWRKALEGLDRGIRRQGAKSTWEKEQEAEREQEAQSRKPGHADFNVRYQEGFRQVKDGIKDLLVDDRTAESSSDPNDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB58</accession>
    <name>A0A2S5BB58_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Association with the SNF1 complex (ASC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB58"/>
    <dbReference type="STRING" id="741276.A0A2S5BB58"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="698"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="819" mass="82749" checksum="796FF3E3F4E43772" modified="2018-07-18" version="1">MGNNASTPQTPGPGAGGSSSRTPGGGGNRGSPRTRNVPLPSLPDDLPSRSRQHSASGSAHADRKGSLRKSTTARDSAHGSSPASTPASPKPHASPSLSHSASRRNPAVPSRPSATGASGPPPPAAAATAGRPSPAPSSAGLGLLGAVGGPRRKLSDRVPIVDDSEGDGDNQDDGEDAPQGTLRGALQGKAEHVVYGPRRGGEDAESRNVLMNPPSAAHQETLSKPVGIAIPGTGPAAIPLRTPGGGAAGTAAGGSLTNAGMGAIGADALIDPDDQSHPGFGASARLTSEVMASTDRMPVVNSPKHEDLPSGSPFTSADSVGTKMTASALDPVGAATATPDDASTVASTAAPTPSHSHEMLLDPSGSRRQIATPQTSFAGALSGILAPAATAAAAPVVPGHSPMSPPTEMHELPPPHTSSATPPISAPNDTVQAPPVPDEALPIASDEIPSGTSVIASPPSSVPGSPAGTFPSPAVLLPPAVINAPVAAIPIPLLSVPSQTVAQNLIAAAVDLGAGDKGVPTLIKWKDEDGQERADDKEGKKARGPKEVFVTGTFAKGWKTKIELRKTDPSDFSALISLPPGPHRLKFIVDDEWKASKHLPVATDADGNLINYLQVNAVNSKLPPNIWQPPVTASSLSPAVASANAGGQAAGSQAAAVAPSSTPTNRAGQLGAGLFWPFGGDDEDPALAQGGSGITLDVDEDDSQWTQEIPIDLVKWGEWEAERDAIENEFYAKHPNGPSDSTPPPEFPPPPPFAGVQPPSLPAQLEKGPLNHAAYVTQGSGDDNSILPKPDHSVINHLAASPIKGGFLSVGVTTRYKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBB4</accession>
    <name>A0A2S5BBB4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_2869</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBB4"/>
    <dbReference type="STRING" id="741276.A0A2S5BBB4"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="290"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="429"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="497"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY74057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="831" mass="88680" checksum="6AF53F11983FFBEC" modified="2018-07-18" version="1">MSEPGTHRYAVVTLVTSDAYLAGALVALNSLLDAEGAPASPTARRFATVCVATPATLGHATLQALDKAFDQVVGVEPILTKSWEELKLLGRQDLAATLTKLHVFRLTQFEKIVFLDADTLVLRPISSLFQVPHRFAAAPDVGWPDAFNSGVFVAEPSSETFEGLRDMMRQRGTWDGGDQGLLNDYFHDWHRLSFTYNVTPTAYYTYAPAYKRHGQDASVLHFIGADKPWNRGTRDVYVPNTASKDYYSLVQQWFDVFERHYGTVSTWDVARKVVAPPSYVRRAPVSLPKLAERTDSGAHLPVPTTPTLVLSPPSPNRAPSPPSGTSQLPPPIPIVGAAPIRRIPSPPQLTWDASRSSPPRDGPPQMREPVPYSTNVWDLESKRAQKQRFEPPAHYPPPPSETHDWYRDILQQKPDPTKVKAVFPWEETATTPSTPAAVPDRPPPMATRTFSDESTGSAAPGSFARTGAGSFTNAWDTVPGIKRYVEGLSKAGRIRKGSNAAGSAARGGSSSSGGNASSSASGGILAPRPLAGDRARQHRRRSSGASATGSSSVAFGFTPAGGQTSVSSPRPIGGSSSASRHPSAPFTKEGDASSRDGDDEEDEDADVSTATDGDATETDEARVSNAPSSERDSDEGIDKLPIKFRRSASHSEWVREASRDGGMGSTDESDDAATLRSVPASPGKVRKPEPRFVPTSPRQPRSPHLTTSPHLSLPSALTRPSLHSLTSVDASTLQRGPVSPRLAPVSPRLGVPVSPRLAAQALRNSTAARLTASGSGSGDGPPIVRATRVFRPETDTSNVKQQGLAALQRFVESMEASAAAGQPGVGPTPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBB5</accession>
    <name>A0A2S5BBB5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBB5"/>
    <dbReference type="STRING" id="741276.A0A2S5BBB5"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="48"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="218"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="312"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="43074" checksum="FAACC4FF1098D80A" modified="2018-07-18" version="1">MAAAGSELPNRRIDSIPQTDATLLDPPVSSEAEIAAATKAAASRTAPLPATWHLASGALSGAASVLMLQPLDLVKTRIQQDRHAGARSSAPSTSSSAAPVPSTSGSTSTPSRKVKVPRAKILSTAREVIRVDGVQGLWRGTVPTLYRNVPGVSLYFLSLSRLRSLIGRSSSFRAKTSSSAPATGKVKLTPAGDLLVGSTARTAVGFVLTPFTLLKTLSESTISIAQSSAAAAATASPVVPKLSAGNPAVALTPSRPPSTFAALRTLYASGGLKSLWRGAVPTALRDAPGAGLFIVFYERGQRLLGMRRDGGKGAVSGGLAGASASLASTLLTTPFDLLKTRRQLDPAHYKTLWQSVKLVYAQNGILGFWEGGGLRVVRKAGSAGIGWAVYEAFVGMGEKRQHLEREREQARSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBP3</accession>
    <name>A0A2S5BBP3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_2747</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBP3"/>
    <dbReference type="STRING" id="741276.A0A2S5BBP3"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000044">
        <property type="entry name" value="Probable U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY74173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="130" mass="14060" checksum="F6652934A72A326D" modified="2018-07-18" version="1">MSDESPAQQPEQPEAAEQQQQDLPGPGAFLKGVVGQHVVVRLNSGVDYRGVLSCLDGYMNIALEQTEEYVNGQKTNDYGDAFVRGNNGDPVHLSTVMMHSVPASSESTQLARADSPPLYTIFDTPRSPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBT8</accession>
    <name>A0A2S5BBT8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBT8"/>
    <dbReference type="STRING" id="741276.A0A2S5BBT8"/>
    <dbReference type="OrthoDB" id="2528619at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="733" mass="78382" checksum="1D44F0AD590D7F16" modified="2018-07-18" version="1">MKARTAPPELETPQDQSTPALSTDLTLSSAPKASTAHAPASTRVPPELLEVIFKLARPPVPLVTIKRVPVSDRAKAFTRLALVHRSWTAPAQRVLAASVVLRSRAQMRKLRAALEAGQVVGPVQEIVLDLKELPKSDGSATVPRRRLEDDDDSDQEEDELPPRARAHADQSFEPDLVALLEKCGADLKILRCRGFGDECFVSLPDNLLSPLSRLDSFEYSPVDTGSPPRSVGALLRLGRLPGLKHLTLRPSSRTVAPVPSGIEAEPALTEQLMILVRSTPSEQQIRLDKARDMFQLVWDLQAALQQSQTATATATATDAAEGLPIATLPFRGLESVSLASLALTPCSLALLLTPTFETLTSLSLISVLICGPSSATTLILALFVQHLVVFELHEHPAQDLYATTVSRALNLTGGPAAARVSIGLSHDHFWELARRLKRVRTLKLYSPHVFSSATDCLPKKLFRLPRTLRELSIGSAGKTVEQERAGIDWWLDRMEELHAMESESLKEKGKEKEDSATNARQVPPLRPRDAPAASAAATAQAASSGALAGLSSGSPTIAGGTQSSTLPGPQMTAASAEDPTEPSDEATAPDDEDDGASESGESEASDRTCISSDVPSEASAAQAAIVDTGGAAKSEAAPKAPETASSPVSDLPAPRLEALTITTNATRRQIRSGRPGMAGAVLSERLDELGEAGTRVYWWGMRLVMLDELDMTRELRIDMTELPSGWVDGESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC87</accession>
    <name>A0A2S5BC87_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Microsomal glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC87"/>
    <dbReference type="STRING" id="741276.A0A2S5BC87"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="154" mass="16982" checksum="4E5EA56276970941" modified="2018-07-18" version="1">MSLFSNIVGDYAYVTAVGTLGVYGLHVFATMRVSAARKAANIKYPAMLADNSEAERDSKANKFNCAQRAHYNTLENLPVFLITLFHSGLYYPRFAAVAGLVWVLGRFAYIDGYASGDPAKRQRGVFQYLGLLPMFGISVWKAVTSMPAVQELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCH1</accession>
    <name>A0A2S5BCH1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCH1"/>
    <dbReference type="STRING" id="741276.A0A2S5BCH1"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="68165" checksum="63EB475FDFC44BF9" modified="2018-07-18" version="1">MQSMIRLDTSVTNTPATSAESSPYDDMPMPFSRPSRQASAELLLPGLRSPVAGKAPVRRTRWMRLVLVSAILCTLVLFGRQPKVTEKVAEVWSSCEGRGMLSPTLAAGDTDDAHRIVVRLHPRASSRRSDRAIPENTRQERPLHPFLTAKRHVLFKPNASPFLVPKSKAGSCIRSESVAVDFKPRPTIRADKQPELFFALCTAPHRATTYSSIWTHYMLSPGAQSPPPGCLVTDAAGQGDVAGMARANDEFRRNGLGCVMRDSSRAGQRYEIRVLALLREAWFEAEERSRDGAAPVEWFVFGDDDTWWSDPNMLRELVSRYDYTEDHILGTFSETRGNYDSFGRIAFGGGGIIISRSLLDKMQQRLEECTEKFHGVTGGDGMISNCAALVRKVPLEKVVEEQLAMRQMDIRGDATGYLTDGSAPYLSLHHWTSWLHLIPGVEGTAAINLMTAAANAVGGPNFLRRWVFDNGAVTLSLGYAITVHREALTKDELGRIEWTWDHHEPRRPSRPGLVEGIEKHTYYLSQVEELLPGLHLFRHTSSHPGVVNGIREIDILWDARSELPSSSRPVWPSRWLPGRPSQPKKVTTAKSLTEHAAAPVVAAKVPKRARAFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD17</accession>
    <name>A0A2S5BD17_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD17"/>
    <dbReference type="STRING" id="741276.A0A2S5BD17"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="566" mass="60890" checksum="3A69EBDFAA7E7136" modified="2018-07-18" version="1">MAPSSPAAAASVADERSPLLQNASKSELEHLDDPTKLPKRRRNAILVAVWLGVFLGALDGTIVATLISDVSSSFEKSNQAGLLGTSYLLSTATFTPLYGRLADIIGRRNALLIALTLFTGGTTLCGLAPSMVSLLIGRLIAGMGGGGLMAVSSIVASDLVPLKQRALFQGLANLFFGAGSGLGGPLGGFISDRFGWRTAFLCQIPVLLLAAILVFRNLRYRIAGQGKSKREMVRRIDYLGSLTLVISLGSLIFALSYKNDRNLPWSSPLVWAPLISFVVSAIAFGLVEAFWSPEPVMPLRLLKTRNAFFVALTNLTLSWVSFSILYFYPLFFEIVKQNSASRAGAHLLPNSIALSVGSLFAGWFIRKTGRYYWLIVITSAFPVIALISFLFLNESSGWFHSWVAVLPSGFGFASVVTATLIALIASVDRSDMATATGLTYLYRYVGQVVGVASSASVLQAVLTSQLRERIVGPGSAEIIERIRHVATSIKDLPPATQIAARTSYRNALHGVFGLNLGIAVLCLLCTLPLREYALPSSFAEEEENRRQRNGGDTPSSEEEEVVAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD32</accession>
    <name>A0A2S5BD32_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_2425</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD32"/>
    <dbReference type="STRING" id="741276.A0A2S5BD32"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY74663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="506" mass="57800" checksum="7D527814C981CA77" modified="2018-07-18" version="1">MAGARRVELAAQYDPKVGLKVTNRAAIANAPFPVEGNGSFSNLQLAAAVLLVPYLLSRFVPYFSFKTTYVALLLVTGLPVTVAYWLVMSRANVRVRDSGIFPGKNLEDYIEIKDAHLREKYHGQKKIPMQEFHDAYFEGKIDIKGDMLELLEWRHDWASFVMTIELMKYVFKNLIPDVIFHSEGQDEEQVTDHYDRGDDFHEWFLGPRMIYTSGVISDSNKKETLEELQDNKLALVCHKLQLKPEDTLLDIGCGWGTLVTYAAKNFGCDATGVTLSHNQAEFGTNRIAKNGVDPSRARILRTDFRNLDKSKKFTKIVSLEMAEHVGIRRYNTFLRDVYNLLDDDGILVFQVAGIRPHWQFEDLICSPLTLARFFLSDSIRGLFMNKYVFPGADASCALNWVIGRLEGAGFEVQNVDVLGVHYSATLHRWYENWVMNKDKVLAKYGERWYRVWLYFLASSVITSRQGGASVFQITLHKNLNGFHRIDLADKHTNIHPKLDKEPSLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD34</accession>
    <name>A0A2S5BD34_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD34"/>
    <dbReference type="OrthoDB" id="2521891at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="125" mass="13816" checksum="5AAE19CF78D05A26" modified="2018-07-18" version="1">MGAREGAIKGTVVGATLMALFLVMWATIFGMVTHADHYLLKWEHEHRVQSERWRTIARSELAAKGTVPSESAMRAWKVDYDAKLRATVESPVSASDDAPAFSSSAPASDRSKILEELELAKQEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDG8</accession>
    <name>A0A2S5BDG8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDG8"/>
    <dbReference type="STRING" id="741276.A0A2S5BDG8"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="520" mass="56367" checksum="DEFBEDEB4C4CBF5C" modified="2018-07-18" version="1">MEALLREVNALLVDFPGEQASLACVLERVKTSTRESTSSAPTLPERVLTEQALRRLAELATPPAELFYDDPDLDEPDLPPPQARSDFLKRVPPMTELAEELLRYSSNAEESPNREELALRATLVVAFGRHTPDSGLGVPGSTAEIAPLLASLSDVLPSSRLPLVRYLLTTSLPPYFKPHPELNPSTGRVLSRPLGGDRGLNAWFDSSEQDPSSWRRQVGLAAVVNRVVEALEPSEVEDLWPYLLPPLLAYLDDFESANKIRGTAILDTLLRRVDASLLRRTGVGKVFEKSLESCFSALSDPNTPRLLAAAHPVALRLAELQYPPMRASDPVSVDKARFDALCKLFASSVIYAWESKGQHAAIETVTARAMPPLLDAMGAASIRYLQVIVPHLTELLVTTATLGGLEGDGTWTLETATMMLEASRALLAVVRNGRMRMARWEGKIGVAVAKCWLGQKGSRASLALRESSAAGRTVLVELDGALRDVLTALDGATTTPISTRLAPLPNFAELLPLRAAEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDJ7</accession>
    <name>A0A2S5BDJ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDJ7"/>
    <dbReference type="STRING" id="741276.A0A2S5BDJ7"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="4">
        <location>
            <begin position="204"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="503" mass="55406" checksum="B5C67E9D84E0E5F6" modified="2018-07-18" version="1">MRKRDCVEIESYLVEDLRFPTSLTGDGTDAMQKSCDYSAAYVTLKTNDGQVGYGLTFTIGRGNDIVCAAVSEVASRLVGWKTADLFSAAGMGKMWNFLLGDPQLRWIGPEKGVIHIATAAVVNAAWDMWARHEQKPLWQLVAEFSPEEFVAATTFRYITDMITPAEALELLREKEAGKAERLAKLKSEGYPAYTTSVGWFGYPDEKVARLTREAIAQGFNHFKMKVGADVKMDQRRLALIRSIIDDPKECAGRPTPSPESLVGKNAGPTGSVLMIDSNQVWDVQEAVEYVKQLEDAKPWFIEEPTAPDDILGHASIRKQLKPHGIGVGKSLPVGIERGVSADENQPALATGEHAHNRMCFKQLLAAEAIDVCQIDSCRLAGINEILAVLLMSAKMGVPVCPHAGGVGLTNYVVHLSIIDYLCVSGTKERNVLEYVDHLHEHFTNPPTINSRGYYNIPSDPTEGYSIGMFEESKAAYVYPHGSYWVNDYQRERAAAIKAGIYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDK8</accession>
    <name>A0A2S5BDK8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDK8"/>
    <dbReference type="STRING" id="741276.A0A2S5BDK8"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="105"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="202" mass="22400" checksum="9DEF9356CD43D035" modified="2018-07-18" version="1">MAQLSNSPLVDRFLSATNSFLAGTTARLDAFVREHYIFTACQLVVLSSLFFWYLQIAFPTPDPATRDMDALRTKAADLAVKAADATVPAPAGDKKELDPPKDTPFTRQQLAQNNGKDESTPIYVAIKGKIYDVSAKRDMYGPGCGYHVFVGKDASRGLGKSSLKPEDAVSDYSTLTEEEMKVLDDWEKYFQKRYNVVGRVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEQ1</accession>
    <name>A0A2S5BEQ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEQ1"/>
    <dbReference type="STRING" id="741276.A0A2S5BEQ1"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF1">
        <property type="entry name" value="AGL149CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="108" mass="11480" checksum="055A252D2E2E11BD" modified="2018-07-18" version="1">MSHVSTGAATLALSASPSVNELVWLSVKPLIRILIPAATGFTLLKRGVFPPDGTRSASLLLLNFLLPCLLFSKIVPSFTSENVHALGPIILAAFFYQALPGAFGIFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEW5</accession>
    <name>A0A2S5BEW5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEW5"/>
    <dbReference type="STRING" id="741276.A0A2S5BEW5"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="125" mass="13957" checksum="EE1652285D524711" modified="2018-07-18" version="1">MARTKQTARKSTGGKAPRKQLAAKAARKSAPAAGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEAAEAYLVSLFEDTNLAAIHAKRVTIQPKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF11</accession>
    <name>A0A2S5BF11_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1596</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF11"/>
    <dbReference type="STRING" id="741276.A0A2S5BF11"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="200" mass="22391" checksum="98185B6FF2CF5FDE" modified="2018-07-18" version="1">MIARVQQPAPAFEATAVVDGFFETVKLEQYQGKWVVLFFYPMDFTFVCPTEILAFNERLADFEKLGVEVLAVSTDSEYSHLAWANTHRNEGGLGPNLKLKLVADKNMKISRDYGVLLEEAGVALRGLFLIDPKGTLRQITINDLPVGRSVDETIRLVKAFQFTDEHGEVCPANWDESKNNATIKPDPTSSKEYFSAANKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF48</accession>
    <name>A0A2S5BF48_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF48"/>
    <dbReference type="STRING" id="741276.A0A2S5BF48"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015376057" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="38"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="581" mass="63129" checksum="C299D43D6579C70E" modified="2018-07-18" version="1">MIRFFGFHLFLTSLAIAAPFSTPSEPLSAVSTLSPRPPIIDLGYTRVQGYYNSTDRQYWWKGIRYAVADRFQAPRTPAAHDHEIVDASSYGSICWQATAGGLNLSTIAVGKQSEDCLFLSINAPAFARVGSRLPVLVWIHGGGVDFSAFLTNAGNNIIAVAVQYRVGPFGFLAGREIAEHGVLNAGLLDQQFALQWVQEHIAKFGGDPHHVTIWGDSAGGGSVMNHIVANGGDTQHALKLERPLFHAAIGSSVFLAPQCAYKSSAAEAVSQALAETLGCHDGSASSYDGLRRVDSAALAQAAVDLAFSKPFGIWTFVPVLEGDDGFLRERASVALTGNRSQLNGERYMGINNLHEGGKFSPTGPWALQLGVLTYVRNPGLVFTDPNLLEDATLDPAELDRRFEAELEHLFPTLDANDRLAISRQYPLMNGSDATSTFERISLIYGDAFLVCPGYWTAEAFGSSAWKGTFAYGSSTHGIDAEWYLGMIWNGRHSESALNSFTGSFEGFVQTYDPNNNPATLINPYWPTYETQGEMYFKTTEFDTASQAIPRIVETSSQVALGVTQLDRCAFWRSEVGSRAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFT1</accession>
    <name>A0A2S5BFT1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BFT1"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09880">
        <property type="entry name" value="PIN_Smg5-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="1391"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1576" mass="170613" checksum="1E25FC7018460ED5" modified="2018-07-18" version="1">MAAVARAAPPSRTGSGHHYMHSTARAPYAVQHDYDYDYDFDSAIPAQYAAAPGPSTSGALSPAAALVNSWRTNAAAALESDPYHQHPTDYYRPQSPVYPAQTGYSHRHRSPNRGPKPTRSSRPPSGLSSSNAASGSRLSLDQQYGYPPQSPATTADFVPSSSSHRARAQIAAGAVPPLPPPVPSSSSQRNHHVHPSADGGAKYSSSHAATSRSSVSLSQHPNSSSRAAGSRYHHSARNAYDADYDRQLAAGPASAAGAGTASSSSRGLFDPRGQGATGAASSSSRRLPGAASSSPRRGQGEERTRPRHGSSTTSTVSPHPSAASTLHPPPLTSVPYAGAGDAPPPSPRSAKRNAGAGERASRSSAAADDRRPARSKREPVQLMDLGRRAGTDRGSRLEPGQHSHGRKTSDAKDSHESLESLQTDFSGRTKSSGAAGGRRRRRAGADGEGEDGEFESGLAGLANAAAGGASKSRQLFDPRKDDPMRFAAPRPGSVASSTTKHAFPSGLTGSTFTLQTESVMNLPDTSGIDDAASGHAPAPTSSSHSKRPDHPILAELKKAYRGILELEKKLQDEHRKVTREAERDADAATGQNAPTAGGVKIQGQGKKYDDAYWVKLAKAHKQLAEAHYSFLQMALDPNIPAGLHSLPQRYNIPTRLWQVAFHQLLERMRHAVVSSPPPTGDDPNEANVLDHLIEFIQFAYTHYSQLFEDPAVSVFRAAWIEQLGDLARYRMAVAGLASRVHAAQDASNDLSAEALQGREDLGDDRAAAPRRRPADAASIGQAALNDWDLEEQETWREMAREWYALGLAESPGTGRLQHHLALLSKGDELRALYHYTKSLTTAHPYLSARESILPLFEEEHQARRTQSDVSQHELFVHLHGMLFTKISLDDFEDCLERFLERLRQEAWSLEKAAEGLTSPHDAEPGLSFADRDWCMLGIINIAALMQYGAEDGVLKKLMTPESGETNEGAATSASTTKRHPHSRQARHDRARDSSSKSQSAPQALMLKRGDGETGITSPALHDNMDDDASELGAEADDVVKRLQPATSIEPEDDPLPFKLAQRLAFSILTTLLDIPFFRAGHEEVPNPYVTILCTFLAHVSYHPEAMRHLERSVPWEALATLFNRISPPVEIRLDTPSKLVGGKPLPEDHCLRGMEWAGRQLFGRGYWREPRSRSAAASPASGLGTGQGPPIEGIEGTTIRIENEADALRFDLAALQGADPLAARLDDEADDFPIAFSSTAAMLAEGRWRRLAICAAWLVRNVPGFDYNLRATNAGQRFSVSGALRIKVARWAREDEDAREAERLSRLALEDRTIPSGDLPSTDDDESDEEDFEDENDSDEVKELKSRRRQLKSIIRQARLATRAPRVSKSGRKARLGSKATPVPHVFPGYTVLVFDTNILLTSLGLLSELVAAECWTIILPLAVITELDGLRRNDSPLGVAAAEAIDYLEQAVRGYSRYLRVQTSRGNYLKDLAIRNEAIDFGTGPETSTQDSARSLDDVILRAASWQKEHFSNRLALVNPRAVAEGRKVPSDTVQVVLVTFDRNLRLKASARGVEATDEKGLKKAIEAAPIGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFW9</accession>
    <name>A0A2S5BFW9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Phosphoketolase</fullName>
            <ecNumber evidence="7">4.1.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.9" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFW9"/>
    <dbReference type="STRING" id="741276.A0A2S5BFW9"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050193">
        <property type="term" value="F:phosphoketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF1">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="50"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="634"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="862" mass="96168" checksum="B390CDA7DBB6C55C" modified="2018-07-18" version="1">MSDSEKAPPPPIVPSLLAGKPDTPISALPVQISPKDYVTKYPAGHFDAIVDTWRLSCYLATAQIFLAKNATLERKLSKDDIKPRLLGHYGTTGGLSLAYCHAQALIRRKGEEEGVEPKMIFVTGPGHGAPAILSNLYIEGAISKFYPRYSLDKKGLEAFVKYFSWPTGLPSHVNAETPGCIHEGGELGYALAAAYGSVMDRPEQISVVVVGDGESETGPTATAWHSHKYLDPAESGAVLPILHVNGFKISERTIPGTMDDTELSLLYTGYGYQVRFVEYKEQGQARMGGGDPADRALHEDMAASMDWAYGEIRRIQKAAREGKPIDKPRWPMIILRSPKGWTGPPSEHGKQLLNNFASHQVPLPDAKTDDEANAYLERWLKSYEADKFFDLSEENIKNGSIFKQDLYKAIPKDQEKRMGFIKETYDAYKPLDLADWQEFGYEKDKDEVSCMKAIGKYLTDVIKRNPKEFRMFSPDELASNKLDDVLSVTDRNFQWDPTTAHKGGRVTEMLSEHTLQGWLQGYTLTGRHGVFPSYEAFLGIVATMVVQYTKFLKMGLESKWRGDVAALTYIETSTWTRQEHNGFSHQAPGFVSTVLSLPSHLARVYFPADANQSVSVIAHCLRSKNYVNLIVGTKAPSPIYLTKEEAEQSCVAGAMIWENYSVDKGVEPDVVLVGIGFELTQEVIQAAALLRRDFGTDLRVRVVNVVDLLILAATGDHPHALDEAGFNSLFPPNTPIIFNYHGYPAQLASLLFDRQHSVGRRRMRINGYRETGTTTTPWTMLAVNETDRFTLAEQALEMVVLNFTTQNNITGDEKRRRVGGVVARAHERISFYKHTSVKMLKYAEETQQDHPDIGTVPTLQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG66</accession>
    <name>A0A2S5BG66_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG66"/>
    <dbReference type="STRING" id="741276.A0A2S5BG66"/>
    <dbReference type="OrthoDB" id="2499604at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="725" mass="77280" checksum="285BDB5E652BE62C" modified="2018-07-18" version="1">MGVFLPTDSPSLWSIPTRFFLSKRNDGDPYLNAQSAPKGPEQANPLPTLIGVVVESIVEVAILCAVGWYLAKRGIVDAKAKKTLNKINTSLFTPCLLFNKVAFSLTPDKLAELYIIPIGFVLISAFSASVAYAMGRVAGLKKGQRNFAIACATFQNSNSLPIALLQSLIGEKLPLAWGPHDTRDGMLGRGLSYLVLFSSLGIIVRWSIGVRLLSSAEAVTEDGAVPGEEGRGSSAGPGGRADVEANASGATIMPSVDGSATSAVREDDHPEREEDTLLARTATRNGDGHGNASNGKGKRASILKSSHNPTAAANRTRESPTAGSVTLITNEDHGEDDATKVADGEAYVRPATRANGGAGTGAAKNQKKSSRVFQSFPNTPIPSVYSSSSLGDRTNDDNDDDDSWNNSDDDEDENDAEWGRRRGFGRQSGWFSSPWGKKVKRGTTRAWKKVKRVAGKFGDFMTVPLWAALLSLVVACIPPLQHTLNKAEPLKSYVRLSCMLWSSSSCSVPITLVTLGAYFYSPSASSAADTSPLRREEQELPPKSWHRRLARVVKKPFVSTANAINGTTQSNDNDDTDALKRRAARGENLTVFVAVMARMVVVPLVLIPLFAYYAKVTVNIADDPIFVVVACLLIGSPTAITLAQITSSAAGQTFERLISKTLFVSYAFLTAPSTILLVLAALWIDGLQHPHKNGPGQGHEHSLVFGPGAIAAGALNATLGNGLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG76</accession>
    <name>A0A2S5BG76_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG76"/>
    <dbReference type="STRING" id="741276.A0A2S5BG76"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="75" mass="8487" checksum="DE3278654BD2F03C" modified="2018-07-18" version="1">MIVPVRCFSCGKVVGDRWTAYLQLLEAGHNEGEALDGLGLKRYCCRRMILTHVDLIEKLLHYNPMERNQALGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGC1</accession>
    <name>A0A2S5BGC1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGC1"/>
    <dbReference type="STRING" id="741276.A0A2S5BGC1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="792" mass="84594" checksum="47C9A01C561A1DD0" modified="2018-07-18" version="1">MTDLQVTAGPAASSSLSPHSYSASVPYMLFSSATAAPPLPSNMGASTSAAAFPHAENSSTSPQQGGVPTNDTGLRPFRSKKVRPCDGCRRRKNRCALPVVGEPCVECRQTGRPCTFDLPPPRRNQKSTTKDGTEDPPSLDAPDGTTSHASTGGGALRRDRHHDLDLAGSKRARPAESSSNGARALAPAAAAPPHIQPASLDQDLPPGMEMSAVTATLTDDLLTHRTAAPSRQISKDAGHAQFVLFRKIPSHRPVVQDEHEKLVRAIEGFISATLPELSPSSIFDHYLTFLHPSMPVLPLGPAPTLDSLPPGLRAAIIVEAFVYLANDPRQATYVCTLFKSSLVADRLLYTSKLSSLATAILELSSAVDPRGDYLLLAKTIAQAQALGLHLDCRAWAIPDSEKSLRTRLWWCLRIHDAWASFLNSHPSHIQKNNQNVELPVLPTDISPVGPAVADVAFVLQCRLAMIVSRLQQEVCTLESFGSPERVLSCDAVERDLDALCGSVSAFTASRVRPVGMDCFLFNLFAFRCMVRRISIEIRIGLGNAFAPDGKTIHLFADFVAFCVSMTELSLGSEQPWYPYTAHILSSVLSSLIRVSLAALGSRPHAQPTHPPLPGDAASRMHIPLSVQLLNDLSLFLGAARRAYRWTRAEAAIERARSVSERLSSIAQADAATDTYSTVVQALSMVDVESSPSGSNGTGSSLAALDLLASLIHPDQPGPSVAAVASSSEPVIAWPPPVQQSSAAQAPPNEVSPLFGNDTLDLPDLEDWLNVLDGCEQWGGGDSGGAWPTLPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGD8</accession>
    <name>A0A2S5BGD8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BGD8"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="43"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="355"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1282" mass="139783" checksum="77D6133A0208BE16" modified="2018-07-18" version="1">MAMQATLDKVRSQLNAQVDATKRAAQLLVAVEETLGDDQRHEQAYWAALTQTLTQLAQDPDAAKPQHEKRKLLEATLYLTALIAPHLDPVTLRQGDHRTALPSLLQSFATQAPTLKSLIAIAEATLSSLSATTLEKDREGARAVYATILSLSADARPKVRRRAQEAVAAILSSPPPPASIHPYAIESAEWICSKLDEALRAAKRGGKQAATTTTATENSPDESRAIALLTFIKNLGPTWPQACTATLLPLLLSTLTLSSQHLTLAALTLLSHLFSASHAETSLSDDHVKQTLEALIEARPKVAEGTEHGEKLLAGWVEGVGEGMVALARTDRTLAATEVPQRFADCLAILPSARTPALRLAVEQAASLMIQHCITDDMIRAGERDLITQVEKATTSPRFAGQSQPHVLALAKALFLRYRTRLDGQIAAATQLSKLLVLVTKAREDSRFEWKKEADSVLDAAIKVLGPETVLEHIPLNLGPDANPSKARAWLLPLLKPGITNTRLGHFRETFVPLSAHFFSKAEDAKAGNRAMEAKVWETLVGQTWALLPGYCEYPTDLVEAFDAEFVSLLANVVYTQATLRPAVFKSLQTLLSTTLSLANSTSPPELLAEQFSLTPQDGQRSLDHLRSLAQTILSVAFNVYGKTSRGEGGFVLETVGSWVAILPGEELVGTYERIEALVVQALDSYSAPASKDDPTLPPSHALLDIMISLVPHSEPVSRRLFDFAMQDKVLQSNDQAVQKKAYRILARLCDERGREVLQGREGSVIEKVVDGAPKVANGAKRDRVSLLAGFVPLIPDDQLHVLPSLIPEAVLSTKESNGVTREAAYDLLVSMGQKLASGGRVKRHLIKGMEDAMNEDEVEATAEEYITMLSAGLAATSPHMIAATIGALGRLTWEFRATLKDEYQTELLETIVVFLGSANREIVKASLGFVKVAVVSFDPSLVTPSLPSLVPALVNWSHEHSNHFKVKIRHLLERMIRKYGYDAIERYVPEDDKKLVTSIRKRQNRLKKKKAAAMDAEGGSDDDEAPRPRAGQQSAYDQVLYGSDSDVSVDSDAEPQQQQPAGETKNRKSQARKNNRRDQDGAAYIQEGEDEVFDLLDDRMMSRISARPAAANTKERKPLDSHFKKDSSGRIRVEESDDSDNQDTAAAAADSARGRPAGMGAYVEAMEGEDGHTRDSKGRIRFNKTQGKRARGGDEDGDGEGDVPVTEGLKELEIKKRFKKQKKETVHVGNEFKAKRAGGDVKKDGMQPYAFVPLQQVAGKKSNQRGPKLGITGLKRAGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGE0</accession>
    <name>A0A2S5BGE0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGE0"/>
    <dbReference type="STRING" id="741276.A0A2S5BGE0"/>
    <dbReference type="OrthoDB" id="2536667at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="622"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="84420" checksum="AC7F32715D2347AA" modified="2018-07-18" version="1">MLASDTGGGTGGHLPMPVLVSASISAGLSTILSLATVWLQLKHYHKPRLQRLVVRILVMVPIYSISSLISLYSLDLAFFLDAFRDVYEAFVIYCFFELLVEYLGGERSLIITLHGRDPVPHPFPVNLFLSPMDASDPYTFLGLKRGVLQYVQLKPLLALITVILKATGTYRDGSLARDSGYTYVSVAYNLSVTLSLYCLAMFWVATHDDLQPFRPMPKVSGALIPRRFLSVKGIIFFSFWQGFGVSILVAAGWLPRYETEKLSVAVQDTLVCLEMPLFAFLHLYAFSYTDYVDKNHLSGRLPIWYAIRDSFGFKDLFLDSVTTLRGTGFSYRTYEPASGTVHSSGLVRDRRIRAGLRYSVDGQRKYWLNQPGLETDAYGRKGENLLKQGLAARPIHEARRLLETRLEAREGYAPLSHEDMEVHVDPDWAASQRAQRDSMSAAGQGGVGLDVGLGWWEGGRAYEAIAEDDDENASDVDSLDFHDPKETDEKEVERLYREARELEYGDWSYPVLDASREAQRRRIRQEEDAILHGRRHGRPSAAHRPRSYGAMAEREREPDHPVPIGTNVMHAASEVAHTILPKIPDPSERRKMLSMFKRRKNEEESRLPPDAVDLVVADVKAEEEEQIRQRRRGEPGGKRTRVYRIAYVPPDERGDSNGGDPYPHRRPHDELENPLADEHTQVKDIVDRDTDLDGPVPPSDASAASEQQDAKVVRVEVHRDEQIVRQAGADERTPSATNGVLQHEDNPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGK5</accession>
    <name>A0A2S5BGK5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLP1</name>
        <name evidence="12" type="ORF">BMF94_0980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGK5"/>
    <dbReference type="STRING" id="741276.A0A2S5BGK5"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="238"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="9">
        <location>
            <begin position="389"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="138"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="513" mass="55172" checksum="FAFFCFF30FD5DF21" modified="2018-07-18" version="1">MSTAAPYPTRRYSVPPAQELRFELENASDALSLKVVSGYAELYGIELVTNLSYGFSYEQRGGVWVPGVNGEGAEIEMRSIDSVYLASESTTSHYFNLHLALTRLRLQARPSSFATTRDLSQPDDEVAPPRVLVVGERGSGKSTLIKMLANWRNRSERATAGTAKPPSGITIVSLDPSEGSWTMPGTIGIANTSALLPTTTPAAPFGTAFSSGPPVPFPPSTASTSTSSDSAAPPYVPPVNVDAYAPLVDPLVFFTGHLSPTVNEPHYELLVQSVADAAKRKVDGAGIASWKAGWIVDTPGEWVEKRGNGHERIKAAVRSFEINVLVVVGTERLSIEMNKLMNTNKTVTVIRVPKSDGASDLDLSAMSRLQALQTRAYFYGGPPLTQGLLSPFSIIVRWSDIRIMRVGELAGTHAPSSALPLGATRLTRDTELVEVDLEGPRAASEVVNRVLAVPMAEEERDGQDKVVKGPVMGFVWVSALDKDKKKITLLSPLPGRLPRRTLIVGSVDWVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGN6</accession>
    <name>A0A2S5BGN6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Salivary gland secretion 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGN6"/>
    <dbReference type="STRING" id="741276.A0A2S5BGN6"/>
    <dbReference type="OrthoDB" id="2588793at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015527949" description="Salivary gland secretion 1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="43007" checksum="BB758DB6C09040DE" modified="2018-07-18" version="1">MPRPALLPFAIATAALLVVVVDSIADDPDLLCDPFTEPGFLHYNEQEPLAAKWVPYSPTCEPATDWISKIAARETDSLAWLANRTILVLGDSVDRNGLQHMAEMLGLPRYCVPYDDFSKKGSVPEGWDERGIPWVIEIPWINTYFTNGFMYGLDDEDNFRQQPDWHPPGKAEDRIDQLFKVHTDQLPFPPSFVSIHSGLWDLAFFGRQDRVSHLSTEIPLTHERVEWWQRRMKHLLKHVTETWPKVPVWLRKLHRVGPVGGASYDWRHTGREDHGAQATFSNFFTDIRIHTIREMQEQVARDLGVPAYDFGETWEGWQRHQDMVHPNKFPGGPVYTQALLHHIWMESEGRDRWRLSKKRAIAHVGALLEAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGQ4</accession>
    <name>A0A2S5BGQ4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGQ4"/>
    <dbReference type="STRING" id="741276.A0A2S5BGQ4"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="289" mass="32686" checksum="7B259993D1814CEA" modified="2018-07-18" version="1">MEECVLCGEPSKLRCGSCSSKAGVSLYYCSKEHQIAVWPVHKLVCGERAHPFVLSPFEQSEADRIVKVFATRAGDEVEASLQSLARMALDAEDTTISQKKAKADATVGRLGHVSFMIHWAQDYPGLEAQRPDPVYVLRWVLSNWYRSDASMYGIAMAPFPETMVFEHEQTVRDLSLWGVDTTSEWYSQFLHRLSSHLSVQYRLMKALKALAPPGAEWTGQSPATTPVTEADMALLDKHEAMLLRFLARPHPSRPRELAEGILRRRRQPFQGCSEEMEMLRQGYARNRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGU2</accession>
    <name>A0A2S5BGU2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGU2"/>
    <dbReference type="STRING" id="741276.A0A2S5BGU2"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000109">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="189" mass="20661" checksum="96C07B6A0A8BB2BF" modified="2018-07-18" version="1">MSASKMAIKRLQKEYKAHQADPPAFVRAKPNEANVLEWHYIFRGPPDTPYEGGEYWGTVVFPKDYPFAPPALRMMTPSGRFEPNKSICTSMSEYHPGSWNVAWSVDTILVGLLSFMLSDEITTGAVKSSDADRKALATKSHAWNVSQPKFKGMFPDYAGEQPKDLPNMSGKPPAPAGPQGEGKAPAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH76</accession>
    <name>A0A2S5BH76_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0852</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH76"/>
    <dbReference type="STRING" id="741276.A0A2S5BH76"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="496"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY76129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="725" mass="77690" checksum="BC147047C97B5142" modified="2018-07-18" version="1">MQPSHLYARPQAPSDIASENFHWGEDAASTIHPEDSVSQLDRRFTGKRRVLGPRAMDASPAIDEEDDSYHVEALRDVYVSPEHIGGDAAHYDSGARDLAPNQSSTSSARGNGAVRAVNPSMAGTGGPLTRARGEAAPVPYSSPSLYEDDEKALAHEDDSRPLVAPAAFANQHVRGDSVDGSGSSGSRIAPYSSQPRGYAALGGEHDGEEDYGGSDRYAAYQSQPSAAGYHPSASRAGPGSADEGAGSATLVGALSNPLGYFRRSLRGEGSASSSRGRRQDSFYAPNELAFDPPHDDKGSAYPPTVPYSGASSHYPSASLDKVPSIDVVPPQDGFTAGTRSPYFDPHRPGLRGELIEPDSLWRRWFWDTTDPERRVWEHKTGRGIQRWPFASWTLALVMTIVLVVELVKMKAITGSVIQTKPSFNVMIGPSAEVLIHEGARFAGCMKYIPDVTNIAWTCPNATNSDTVSSAAVSCMMSDVCGFGGFNSQTDGPGGPNQSFRFFVPIFLHAGIVHLIFNMLAQCTSSAMVERAMGTPRFLVLYFASGVAGFVLGANFALVGQPSVGASGAIFGTQAALLVDLLAHWKIEYRPKRKLLMLVVEVIIGFGLGWVPGIDNFAHIGGFAMGLLVSLLLFPIIHPNRTHKLVFAGLRILVLPLIVVFYVVLVRNFYTSDPSTACSWCRYLSCWPTASNNHCKGTGLSTYSTSSAVLASLLTILFSSFAMPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH84</accession>
    <name>A0A2S5BH84_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH84"/>
    <dbReference type="OrthoDB" id="3210850at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="35704" checksum="EBF41BC893C24576" modified="2018-07-18" version="1">MTPGYALVTSTLSSLVAVRLANVKSLRNISLIQFLALLLLMSSLIFVITAGIISLGLGTTNLTPPACSASTWPCVLIYASTKLVLYTILLEKVWAVHGLAAIGKRNRFSSRWYCSGALLVGGWLAVAALIIHGRLTEKRGDRCYIGIKQYTSIAFLVVDTVTNGYLSIAFLQPIWRSKSGAIRTLARRSSLAALVSLMTSFCNGLALVILHGRELSWICLGSCALDLTINAIITYAVTATPSTSVLTPPAIVEVRPTGPGHSCRRARRLDLSSISIQIIEEVAFDEEIVPYVPLRLGTRSAAGGEPFLREPPPAARAEGSRPLLLSEIAPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHE9</accession>
    <name>A0A2S5BHE9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000007">
        <property type="protein sequence ID" value="POY76200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHE9"/>
    <dbReference type="STRING" id="741276.A0A2S5BHE9"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000006">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="4">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="312" mass="34714" checksum="015BA0E836CC6D7E" modified="2018-07-18" version="1">MAPDKQETHWLIKAEPDSRIEKGIDVRFSIDDLEQKRTTTWEGVRNHQAKNFLRDRMKLGHECLFYASNCKEPGIRGLARVCKEGYPDYNAWDPKHPYYDPKSKEDDPTWYMVDVEFISKLAHPIPLALLQLVSRTDLSELPSSLSRYLTASHLAAIRSSALLSRGRLSVQPVSDELWEACVLMGDKGGWEEWDEWTDGKGKNKAKGKANGKGIGKGKGKVGAESDEESTSKVTAKKEEEDAGESGPRSKKRANVEQDDSVQDGDDDDDNDDSESGEGVAARSAKPAAKKNKVKKDEVATPTGRRNPRRGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHU1</accession>
    <name>A0A2S5BHU1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHU1"/>
    <dbReference type="STRING" id="741276.A0A2S5BHU1"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="757" mass="78455" checksum="5CB347DD3F12844D" modified="2018-07-18" version="1">MQRPRSTRTQRPAPADYSGSGASSPPGGDFGGTRASPLSRTDSTQRVDSAASARSRSGSTTALRQSPSSADSPPQPGTTAQGAGPARNDASRVSDASSPADPTANARQEQMQQLAQSAYHADQLNKRDKGKAVARAERVDPTARTGQIAEEDASGGDADELKRQQQIERVLKRAQAAKLARNFRNRIQLAAFKNQRGWQDVQLDVIEPHFEQEAQQRRLQAGQAASLASAEQATFGGLPGAAGPSSAIHLPSPHQQHAMYQELPHYASSHTPSDLYRPQLGGGMEAVLAGNLARYDDDYASASAISMRQQHPPPPKRARVEHPVNSSYNVHSVYAAPPVPPSTHATSPYATTQVYAPTLASGSRYTQNIPPAPSARPGAQYEHGWDSRAVYATSNGHASARPSRAASHAANELYSLPMPAHHRGNNHNDSSPRTRSASRRSPPKKQPLSSTDPTFSSFVDAANALTGMARAPSDPAMSGAGSQGGNSDEGAGPRPRSSMEMSASHSGSGMLPPPQLSRHSSSSSSGIGQAPVRPSTPEQQVVKLPGAPNGGNNSAGDGASAEGAAELMLFLAASPSPVQARRTVPVPTLGDGMPKGRRLFSGTGDSGDTSFGGELDSFASTASANVSAPPSAKSSASASARPPFATASPSADPSKHRFGGAQAMTPSHSQQQTQVPPVPASNVVSTTPATPGRRQRQPSLAGAWESFINASPSPKRQRKSRGSGAAGGYPSENGELGLSSEGGIGGGPGNGQAQVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHU2</accession>
    <name>A0A2S5BHU2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHU2"/>
    <dbReference type="STRING" id="741276.A0A2S5BHU2"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="797"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="848"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="873"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1050" mass="112017" checksum="74DBAB0B91660F00" modified="2018-07-18" version="1">MVQSAQGLLSLLDEPDAALQSHALANIDNRIDNLWAEVADSIVKIEALSEDTAFPSRQLASLVASKVYYHLGNLAEALSFALGAGKLFDVERTKDSSPSEAEYVDTIISQAIDSYTAWRTAAATSATTVDPAAVSGDVDARLEAIVERIRSLNGQALGIALASHRLDVLERVFRNTRDASLLQWILQLVVRESVAIGGTSRSYKNEILRVLIKLYESLDNPDYFSITHCFVYLNDPSLASSLLNSLLKLDSPAGSPKEDEVLIAYQIAFDLAETATQEFLQTVRASLDVSKAEAAPVVAEGSEAAPAPAQQDDAKPKEGSELHRERLAAILSGEESIKLYLEFLYRNNKADLLILKDTLDALEPRNSIYHSAVSLMNAFAHAGTTSDKFLRENLDFLGKASNWSKFTTTAALGVIHKGNLAQGKAILEPYLPPAGDSGARGPGGSVYSEGGSLYALGLVNANHGKEDIVRYLLDSMKGSQEEVLQHGAALGLGVAAMGSGNEELYDELRNILFTDSAVAGEAAAYAMGLVMLGTASEKALDEMLQYAHETQHEKIIRGLAIGTAFLVYGKEEEADNVIETLLGDADAILRYGAMYAIALAYAGTGNNKAIRKLLHVAVSDVSDDVRRAAVTALGFILFRNPTQVPRIVQLLSESYNPHVRYGSALALGISCAGTGLEEAIKLLEPLTKDPVDFVRQGACVSLAMILIEQNETSHPKVASTRAIYKKTVSDKHADPMAKFGAALSQGIIDAGGRNVTISMQNKSGSGNMPSIVGMALFAQFWYWFPLAHCLSLAFTPTAIIGLTHDLKLPKFEFTSNARPSLFAYQPATKPPEKETVEKVKTAVLSTTAKTTARAKAKEAEQKDGEAMETDESSEAKEETKDEKPAEDAEMKVDEAAAAGNANGDDAKKDGKTARKQPEPSFSQLENLARVVPAQLQYVSFPAESRYVPVRPVNAGSATASNASVALSRLSSPVGTGGGILLMRDTRPTEEAEYLELEVLKAIDTSTPAVPAAAGAQSGAGTGAAGPSDSDLASAPIADTPAPFEFSDWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIQ0</accession>
    <name>A0A2S5BIQ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_0213</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIQ0"/>
    <dbReference type="STRING" id="741276.A0A2S5BIQ0"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="16">
        <location>
            <begin position="126"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="14">
        <location>
            <begin position="231"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="17">
        <location>
            <begin position="463"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY76623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="612" mass="67890" checksum="9AB77ABDA065C28E" modified="2018-07-18" version="1">MDNAKKTIRIQDEDRESKFGSVFSVSGPVVIAERMAGAAMYELVRVGHDELVGEIIRIDGDKATIQVYEETSGMTIGDPVLRTGKPLSVELGPGLMSNIYDGIQRPLKAIAEKSDSIYIPRGINTDALDRGIKWDFDPLNYKVGDHISGGDIFGKVYENSLVSDHKIMLNPRGMGTITHIAEKGSYNIDDVVLETEFEGKKTKHTMLQLWPVRAPRPTGDKLEANYPLLTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQAVSKFSNSDIIVYVGCGERGNEMAEVLMDFPELSIEVNGVSEPIMKRTTLVANTSNMPVAAREASIYTGITLSEYFRDQGRNVAMMADSSSRWAEALREISGRLAEMPADSGYPAYLGAKLASFYERAGKAVCLGSPNRTGSTTIIGAVSPPGGDFSDPVTTATLGIVQVFWGLDKKLAQRKHFPSVNWNVSYSNYTRVLQPYYEKTEPDFLHYRNVAKQVLQKEDELAEIVQLVGKSSLGEADKVCLDVARFLKEDFLQQNGISTYDRYCPFYKTTAMLKNFITYYEEAVKAVEGESMTWTRVREHTSDLVYRLTQMKFLDPADGEEPNKKELEQLHQDILRQFQTLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ41</accession>
    <name>A0A2S5BJ41_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ41"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ41"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="270"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45039" checksum="2F957018B7A7635E" modified="2018-07-18" version="1">MASASSRSSTPAFLKPTRESLSDILMTLQEREQQRRLAAQRARLFRGTAATHAGGKAAQCDGKEEVDGSGGDWFSVAAGTQPDNVNKNRYADIIAYDRTRIVRPREEGSPLDGSSSGYVNASLVREPDLVLDEDTLPRQWWVAAQAPIASTIHDFLSLLLHPPSSPSCSRALPPIQLVVQLTPLVEGRRSKCHPYFPDQVGDTALVQPSSSSTQERGIWIRLESKEEKDGARESKLRLGYEGDERGRQVTHLEYLGWRDHGVPESAPHLLRFIQRVHALNRRLTTEDGVTSGSASSQRSPILLHCSAGVGRTGTFIAISSLLPLLELEARGPLEARPSKVDFHPLGPYPLETILRADGRRESSADFVGATIDGLRDQRTTMAQTSEQVAWVYECLREAWRTGLYRSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ50</accession>
    <name>A0A2S5BJ50_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ50"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ50"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="186"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="626" mass="68590" checksum="6666EB20BEB7A342" modified="2018-07-18" version="1">MVADIIRDSTFGQIVNYLSKGKYFPYADQRPDYVPPAHFLHRDVSIFPRTDSETPTTLTSAAVTLVNEAAVCSEIVAANKAGFDMHEKDRLDAEKQLQSGVPSAKSAKTPYPWLVTFDENDPDRPMSWSSRKRVFVGGLIAVLTFGFLFPLPSSSAAMLYLLSGPLHSIWSPSLDSIPTTYFTCFCLSVSPCSSYLADFGSAIYTPSVPGLMEEFGISQVGAISGLTLFVAAYGISPMILSPMQELPKVGRNPVYIIGLALFVIFQIPEILAKNMATILVFRFLSGFAGGPALATGGASMADIFPVKHLAVAMGAWAIGAVSAPTLAPVVGSFAAEAKDWRWPFLELLWLSGATFVLLFFFLPETLESTILVRRAERLRKLTGNDLLKASAELDMVEGETLLQSLKVTTQRAFRLSLEPALAVIHLYLAVIYGVFYLWFEALPLVFTDGYGFSLGSSGLPYLGFIVSASVTYTFYVFYQRWHIQPRLEKNPNTPPEIRLELGVMAGPLVPISLLIFGWTANRTHWMGPIVGASLYLPPVFLLFQSCLMYVSQSYPMYAASVLAGNDLFRSVFASLFPLFGDKYFRALGVGPGCTLLAGVSALMVPLLYYIMKSGGRLRARSRFAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZX2</accession>
    <name>A0A2S5AZX2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000148">
        <property type="protein sequence ID" value="POY70080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZX2"/>
    <dbReference type="STRING" id="741276.A0A2S5AZX2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="60993" checksum="A7BCA8578FF49D6F" modified="2018-07-18" version="1">MSTLLELSTVQVVLLALSLAIGRFVYSYRDYRALGTRPRPDLVPFPNKQTYLLGDLLAVWKDRKFYLGRFWNNQQRHAHLLRDEKGRADPSKAFTVTLPGIRMILINQAERDAFDNYEKGPLFRRSMQQVLGDGIFVVDGHQWRYVLVSMMPSGGGGLTTPRSLQRKATSKIFTAGNFKGIITSSIQTQLGKLLRVIGGHADRHEAFDLADLFFRFTLDSFTEMAFGMSTGALDTDEPVPFAVAFDYAQGVMDASPFSPITERFNGTKTKMDEAVRILDEFAYEIISQREIEGRDGKSGADTDLLSLYMALRDEGGEPLSRSALRDALLNLIIAGRDTTAQGLSWTMFRLLREPQYFAALREEATQLGTNVEDVDYDTWRNDMPTATATFYEGLRLHPSVPKNAWQAKGDDVLPNGGPRVEKGDLISWNDWIRARDPEIWGPDATAFKPSRFLGPDGRLGRPDEWTYHVFNGGRRLCLGMNLALFEGSAVLAALSSEFDWEFEAGYLDGTEMCEMDNTPLYRPSLTLPMAAPLRVRATRRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B096</accession>
    <name>A0A2S5B096_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B096"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17681" checksum="3D061247EB34EBA1" modified="2018-07-18" version="1">MSDTQKEQPSVAEPSVEAPKSPSSSVLLTEDGELSDKLYEVLQVVFNKYAKFPDSAPAGIDDALARAKTGSLGRQEMNAFARATNGQDLPDEQWEELTTYLDVNDDTELTFKGFTALYSLQTENDEAETKQDLEHWGHDPKTLELVAKPEGVEKAAEPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0C3</accession>
    <name>A0A2S5B0C3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial glyco protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0C3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0C3"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28677" checksum="5FFCDB5BCE333CB2" modified="2018-07-18" version="1">MLNRTLARTATTLARAAVRPAARLPARVAVVPSLRTFTTSFARFEPTALSTKLGEELQFERDNADNATEPDFLAAFKAEGVWQVVDEEGSDEIILTRTFGNENIRLIFSISDLDAEQDLPEAFQDEEAADAGSGGLGDEAAAATETSFPVETSITITKPSGGALTIDAIAQDGLFTINNIAFYPDADVALGMTSEDDWKRQGLYMGPAFDNLDEGVQSEFETYLEERGVNSALALFIPDLAEWKEQKEYVKWLEGTKTFLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0C5</accession>
    <name>A0A2S5B0C5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0C5"/>
    <dbReference type="STRING" id="741276.A0A2S5B0C5"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="170"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="355" mass="40395" checksum="EAFF45752AF9033F" modified="2018-07-18" version="1">MWNASSPYAAYAPRFPSPLPDSRYPFYHAKRDQLVPGWSDGLTLLVAPVVVYWAYSLFFHLIDNLGWDCFERHRIHEPEEVKSKNRVTVPEVIRAVVIQQVIQTVTGWVFVVGAAEPIVDAAADLNAWGVWLAHGAVSVLGTKRGGDLMARYGQQLAEGIYWWGVPAIQFVIAAFILDGWQYMMHRTAHQVTFLYRTVHSWHHRLYVPYAFGALYNHPLEGFALDTCGSVLAHEIVGFTTRQAMLFFVISTMKTVDDHCGFAFPWDPFQHITGNNADYHDIHHQVAGLKKNYSQPWFISWDLFFGTRMTREEYRNKVAKRTHKGEVPPSQVNGPNELAAPPTSQRNGIALKEKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0F0</accession>
    <name>A0A2S5B0F0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0F0"/>
    <dbReference type="OrthoDB" id="10370331at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015509184" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="22225" checksum="92C09540F0F0C781" modified="2018-07-18" version="1">MKWTRNLAAVTLSTLLVTAQSDQTSNDTADLLPDFPAPCVSACDPFNASVRECGQLAESSESAAISCLCDGPFQSQLGACGTCILQNTPDVTHSESYFVIVQLSATFAKQCGKPVHLDGASPEISSALERFGAEGASTSAAGVDAAVTTSSTDQVATPRTSAMTTSSPSVRAAATSGVPSSAAPSGVSSGSAAAVETSGAGGQARAWCSSAALALPLLVAAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0L2</accession>
    <name>A0A2S5B0L2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Small monomeric GTPase</fullName>
            <ecNumber evidence="10">3.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0L2"/>
    <dbReference type="STRING" id="741276.A0A2S5B0L2"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="212" mass="23530" checksum="FFA1EB9DE0418944" modified="2018-07-18" version="1">MSAYDDAPVMPVSRPDCKVKLTCVGDGGVGKTCLLIVFSQRRFPTDYIPTVFENYVLNKPFDGKVVEFALWDTAGQEEYDRLRPLSYPETDVLLICFCVDYPVSLENVEDKWYPEVAHFCEGVPIILVATKIDLRKDENAISLLRAQGRHPVTTEEGAAAARRIGARYAEVSAMTGVGVEEVFDQALREAMKGSSSLIGRSMKKRKGKCAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0Q3</accession>
    <name>A0A2S5B0Q3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0Q3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0Q3"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="443" mass="47830" checksum="B53BA7878A14672E" modified="2018-07-18" version="1">MGLPRFPIAATNRLATLPVEALTRIFAHLLGHAVDRNDRLATKGTVTRFHSKQPPPLEIAAYLTRLVNFTPFPRDAIVLAIVFLNRITHLPYTTERDIHPTPLLNARPPRLPPRPPQPIHVDDADQEAKSPRSASSPVDGSRLSAPTSPIHAVSPLPPSPTISSVERPRATPFLNSYTLHRLLLTSLLIACKFSVDGTLSQVRAAKVGGVTPHELCKLEGEGLRLLGWRLMWTLDEVEDACREVERVGEQIGVLDPEQAERDAATPRPGASPASSSDTIPSSPTAGDLERPASPPRAGANAFYLSVKDTPPRRSSRERPSHLSRDPSSSASSSVPSSEASTSRSSSEQSSPLLALKPAGLSAFEQNLLPELRSSQREGRSRRDSRAAIQGERDEITPPSSPASETSIGEQTDFDEKSSDTGGDDLTRASSETIRRVEGMTVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1X7</accession>
    <name>A0A2S5B1X7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6176</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1X7"/>
    <dbReference type="STRING" id="741276.A0A2S5B1X7"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14528">
        <property type="entry name" value="PFA-DSP_Siw14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000024">
        <property type="entry name" value="probable tyrosine-protein phosphatase At1g05000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="322"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="499" mass="53397" checksum="AD8D8E987056E9B2" modified="2018-07-18" version="1">MDSVRERRVTDGGAVTGDSSSVAARPAEDQLRDSTTSHAGRIPQWMLMLMHDRGSLDYPERSRSRRRHARPEVSSEPAAPSEVDIISASRPGPQPAQGTVPIGAEALEQDGGSSGVAEQCPPFEAPFPTGDGPGEDPPRSAYRDSYGDFSSASSTTSSSTSFSGFDSRSVSSVTSASSATTFSAAGWNGQAGSPSASASSFGDRKRSPAGFISREHSAHGLHSLHHVRKDGAGDSGAGPGSPTDTLGDATLCLSKLSLPVTADLRAPDESDSTPLASTSLLEAPSPPRQNALAESDETAATLVPSTPTPAPHEDGTFLAPQNFATVSANLFRSSFPRKEHFPFLKNLGLKSVMVLVQEPYPEENADFLREEGIQLFQFGIPGNKEPFVSIPDDKVVAALTTIIDKRNHPMLIHCNKGKHRTGCVIGCLRRCQSWSLTSIFDEYRRYSTPKSRAMDLQFIEAFAGLPDVWRLCNRDQLPRWPTLEPPPLPTPADPPSQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B251</accession>
    <name>A0A2S5B251_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B251"/>
    <dbReference type="STRING" id="741276.A0A2S5B251"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="8">
        <location>
            <begin position="55"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="278" mass="31177" checksum="77204B857C2C0153" modified="2018-07-18" version="1">MAAPESPPTAPAETVTATQRNRQNHRETWPYGNYRSYYSFRPASTGTDADAEQLDHRLALLDPALFNGKRLLDIGTNAGKVAIDAVRHLAAERAVGVDIDPLLIQDAVDNARLAELNLDTRGASDLDTRTDATPALQRDDESAPTVAFFEANVMEDGWFDHASRDPRLFGTDVVTLFSITKWLHLHNGDAGMRRLFANLYAFLPAAGVLVVEPQEYANYRRAVKKNKDLRETFKALEMRPPFDAELREVGFVLEQQIDREEGGFSRPLLVWRKPTTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B291</accession>
    <name>A0A2S5B291_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="5">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_6075</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B291"/>
    <dbReference type="STRING" id="741276.A0A2S5B291"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000007">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="17"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="188"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="316"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY70897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="560" mass="60688" checksum="110EC86614B1F0D7" modified="2018-07-18" version="1">MSDYSVKSVQTKAYQDQRPGTSGLRKRVPVFKQEHYTENFVQSILSAIPGGPKDTTLVVGGDGRYYSPEVINIIVQIAAGNGVKKLVIGRDGIFSTPAVSHEIRARKATGGILLTASHNPGGPNADFGIKYNMDNGGPAPEAVTEAIFESSKSIKEYKLVELPQVDLSKLGESKLGPIEIEVIDAVKPYTAYLKEIFDFELIKSYVHSDDVSVLFDGMHGVTGPYARSIFVEELGLPESAVQNCVPSPDFNGGHPDPNLTYAHELVDAVEKGKITFGAASDGDGDRNMIYGAGAFVTPSDSVAIIADWADCIPYFKKGGVKGLARSMPTSTALDRVAKAKGVEYFEVPTGWKFFGNLMDAGRLSICGEESFGTGSDHVREKDGLWAVVAWLNILAAAEKKGIKGINGVLQDHYKKYGRTFFSRYDYEEVESDKAQEVMKELESAYGSSSFVGSTLSATSSSASFKVTECGNFTYTDPIDKSVSKNQGLYTTFEDGSRFVVRLSGTGSQGATIRLYVEKYSKDASEYDRDTQEGLKPLIEVALATSKLVEHTGRKEPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2A8</accession>
    <name>A0A2S5B2A8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6092</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2A8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2A8"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45050" checksum="ABF51EE3CFA1CB75" modified="2018-07-18" version="1">MAERTSSESSSRTMTGDRDNNNSRGTNSAAGKQGERPESHSLELHEEQVAEQYRQERAPKDILPNSEQVRPATEEPPLETGNATLGQKANTLPPKEICSVYEPMYGPWTVHSFLIFGSFWGVLTRLGFQWIGGFASTEVFPLFWAQIVGCFVMGFCVRKKNEIERVFPPFFVMLGTGYCGSVTTWSSMSEQIFADYANLGKPAGTSRFDGFLSGTAIFLVTLAAVQGAFQVGYHLAIVSPIVPVRPRRARRSQTFFNILTILVGPVFWVGGLMILIFGPASWRQPFSFAMVVGPFGAVVRYHLSRFLNPKNSHFPFGTFACNTLSTTIVGVMYLLARHPRSALGCSALRGVVDGFCGSLSTISTMVVELRGLSTRDSYIYILVSYAAAQAVLVLTLGSYVWSGNRAPTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2F8</accession>
    <name>A0A2S5B2F8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formyl-CoA transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2F8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2F8"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49079" checksum="E1FF7E09C81517B4" modified="2018-07-18" version="1">MFAVRTRAAASLSSARRWLATAAMPPPLKGVKIVDLTRVMAGPYATMMLSDLGAEVIKIERPGSGDDTRSYLPPSAPLIQTPPTPPPSPKLGADNEPQLRIDDWNSMPPESAYFLQVNRGKRSLTLDFKKEAGKEVLRALIKEADVLVENYVPGKLAEMGFSYEECRKLNPRLIYASISGYGQTGPYAKTPGYDVIIEAEAGLMHITGEEDGPPVKVGVAVTDLACGLYAKSAILAALLSRSQTGEGVHIDANLFDSQLSLLANIGSNFLIAGQEATRHGTAHPSIVPYQVLPTQDSFIMIAGANDGQFSKLAKLLDHPEWVSDPRFSTNSARVVNRETLIPLIIAALGEHPTAHWLDRFKGQGFPFAPVNNIRQSFEHPQTQAREMVKEVDHPRAGKVKLVAPAIQYNGHRMEFSRPPPVLAQHTVEVLRELGYEDRKIAELQQQSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2J7</accession>
    <name>A0A2S5B2J7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_6089</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2J7"/>
    <dbReference type="STRING" id="741276.A0A2S5B2J7"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000005">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="336"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY70911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="740" mass="82357" checksum="65B378DC2006C6E6" modified="2018-07-18" version="1">MNNFDAGSVYSVPVYGSEASGRTNASGFGGQVDNTKTIADLQQFVTEFREHDAFIYRDRLRANCLRKEWTLEVEMGHLIGWSEDLASRCRNEPGDILPLFEIAIRNVARMLLFPTAATEDARLERQKAVPEIQLQLRSGSRLMQFRELGASNISRLVRLPGIVISASTLSSRAIRLHLQCKSCRHVTSMEVQGGFSGFQLPRKCTAAPTAGEVKDCPLDPYAIVHDKCSFVDQQTIKLQEAPDMVPVGELPRHLVLSADRYLTGKVVPGSRLIATGVYSTFQAGKSRRDTPVALRTPYLRVLGLEVDREGAGGFGARNFTAEEEEEFEKLAKQPDIYEKFARSIAPSIFGNTDIKKSIACLLFGGSKKILPDGMRLRGDINVLMLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPQSREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTILNSRTSVLAAANPIFGRYDDMKTPGENIDFATTILSRFDMIFLVKDEHNEARDATIAKHVMNIHMNRATDASAVGEIDIETMKRYISYCKARRAPRLSAEAAQQLSSHFVALRKQVQQVERDNNERSSIPITVRQLEAIIRISESLAKIELRAEVTEAHVDEAIRLFRTSTMDAVQAGNVDGLTKGELMEEIEAIEKELRQRNRLAVGRTLPYSSLRNFFVTQRGYTQHAFDRCLMVLERSDVLQFLQQRRLVRRIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Q8</accession>
    <name>A0A2S5B2Q8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Q8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Q8"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000053">
        <property type="entry name" value="Ribose-5-phosphate isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="337" mass="35928" checksum="C1F5C4A0ACC5E7E9" modified="2018-07-18" version="1">MSSSGLQPLAPLSENPKLHPGPGSSNATAPGHNSRRASHSSSGRPDPLGSISHASASRIGPGVIPTGLRIVPHGELTAEEKAKRLAAYAAVDAHVKEHHKVLGIGSGSTVPYVVERLCQEPHCKANSDRWFVPTGFQSKELIVKAGLNLGDVDQFPTIDVTIDGADEVDDELNAIKGGGACQLREKVLAEAATHFIIVADSRKDSKVLGTNWKQGVPIEVAPFAWAKVFVNLQKMGCEKPTLRMGKMKAGPVVTDNGNFVIDAVFSESYMRDPAELLHRIKMLTGVLEVGLFTGMAEAAYFGAPDGTVTCRWQDGRREKVDAVARLDVAEKGGQLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B316</accession>
    <name>A0A2S5B316_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Chrysanthemyl diphosphate synthase</fullName>
            <ecNumber evidence="4">2.5.1.67</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.67" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B316"/>
    <dbReference type="STRING" id="741276.A0A2S5B316"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033849">
        <property type="term" value="F:chrysanthemyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="206" mass="23198" checksum="B8CF50B77CABD3C2" modified="2018-07-18" version="1">MKPGRNTPCPLRTPEPTAAAFNPGARLRIHTPTARPNSHLVTQPGPHQTEQVFAKADTLIRVCRGRVRTKTVKRASRVVIEKYYPRLTLDFHVNKKICDEVAIIPSKRLRNKIAGFTTHLMKRIQRGPVRGISFKLQEEERERKDNYVPEVSALDNQGVPIDVDPETKDLLKQLGFDALAVNVVAPQTSFDRPGRRNVVGLGRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B338</accession>
    <name>A0A2S5B338_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B338"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="553"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="958"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1103"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1025"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1116"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1143"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1240"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1340" mass="141242" checksum="120FC15379859677" modified="2018-07-18" version="1">MSSPPHFHPHLLNSQAITAGAPPRQSRASSAFSRLANIAALSAGTTTTASGAAAAAPAASSPTVAASAPTATDLVHLPPPSATSRSGALDALETIAHADHDRWRSKSTGPPPPPPLSTTTATSATSARVRGDDKLAATANESAAHRYEPRARTSGSRTGWRARDLSESRSRERRPPLTFGDVSGSGFSGLGGGGGAGGGGTSYLGSVSESPSSLSFRTGWAGSGGGILGNSVGGAGGGEQLPPNASYSAFSTFGGPAGGVDSHFFPHSSSAFSFEMGGSVSNSPWDSSYRSSLAGSPSPFNSDTRSSSVPRQPSGLPSPLQPRSDPTAATTSAGNLYSSLAAAGGSRNGLDSLHASPPIRSPASVPTSFARTSSPIGGGRKLKDSSRGLRYTVATPARDKGLVGLAKPPKDAEQGRVAVAGKTSLKILRVPHGTRRKREPSPQPPPSRDDSDTETLSRRARAVEAVQAAFPASSIAARRSRSRGSPAPHGNNGSGFASYSSSIRDGSTPRFGLDEELAEREVVTEVMDVRIGSKLGPTYLFSDVRWGYGDQLKYEHDRAVNRVVFGGQTGNWLMSGGQDGQMKLWDIRESRPASMILKASSPIRHLSFSPSASQPFTLLAACASGTMIRYDVRYVSRQNGGATDRIAGHVGACLAMDWRDGFACEKSSDMSSGETAGGGREGGWVVTGGVDRTIKVWDFSLPTLSTKPVRTLYTSQPVHSVAWHPTRPTELVSSPMQSLGLGTEGSSSSFGDEVPSTPITTSDSAMAAMIKGETPVARTRTDRYAWKNEIEVWDVRRPYFPKFAIKTDVPISGLLYNDDETIWTTSRGCPTFQQFDIASDSYSLLDSIDRPGSTWNTEGDFAFVEDGRARLDVPFDRTHGSMAVPVDSVKFRPDAYVNTVPQFDPDFSFEVFAFLADNLRLSGAIGEVCDHNAAVSRQAGRSDASQLWSTLKAWLDDAPDPAPTVDSPPDSMPDTSELLMGPPEGRQMSRDAARTLSPPTSEIAASARRLSDSSSRSRPSRRTSVTGTPRQSRTSGQPTPAQATSRSRLDSFAEESTASESESPDPANLFPELSATSSDSDEDGHGRLERIRDFNAKRLAASLSALDGTANEAARRATSGSRRTLSTSSGLGAPATARDDAVGESALSSSSSGSDLDDDESADAPGVSDATRGRRSRSARIASMHASLIASRSRRPSAGQPQDSSLPRGIRPPDDPLPRSASGQRGQEPMRALQPHGARPTSSVGSQRLPSVEARRRASVQKRVASQEVPITAASLKLAIGRKHAAQLRELLQHRIKTVLAEYAEQASFSPTRDAHQETFSAASICMWLPLESARPTQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3A3</accession>
    <name>A0A2S5B3A3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B3A3"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1484" mass="157347" checksum="AAAD8B88F662BC7A" modified="2018-07-18" version="1">MTAHQVSLPHICPTVQVLTAPELAKALSRNRFDSLSHLLAPFLSAPGSERVQTRTPATYDQITHDRFPVRLVDRGPGHIAAEPAVDLWLDQVGQDVAANVNGWLANDTGNSRDEPWYTAVREAVLSNRDLGGDVDSFNSPYATLVALSTANPDPLNALASLWEQAHASAADQPDRLRFVLLVHDCGHTDAGIDWTEAQKLHDTVRKTYGLHTALVPLFSAAQAAERREPAAPDAAALWPGPPRRARNPPALVGLGVDDGSETSPEIMTPDYASSDGPIGRELSVQDLTALTTFAREFVVQSLVPFLERSAIVAHEQWVASRRSLGGRLFSVGRKYFGGGGGGGASGGPNSNESSRAGSPGPASAQSRDGYNPTKGVYVGGIHPLSCSSLSRGSLSAISNRYHPLSQLSQTRRLADLCLVLGDPKLAHAVYESLAKDHRTDKAWRQAAAATRMAGLSSLLVYSATIQAAPTAASTASSSSSTPSPLGSPNNNPDAYLVAAASLSSLPPTPADYDSLRSTLLYYELYKLLAHAVPTAWTLASDALVRTAGEAEEVVSAVLLEQAAKADWHAPVGILAGGSSGASNKGRRRKYAFHLAMAAARYEKCGIKALSRRSLGQAAALFQPPVPLLPKAEAETDAPSSPTKLVANDASAPPPITSLSDPRFPPPSDATTLAPWLAIRTYMHHSLARQAYTVGDALDAVDHFLQLLVGSAADVAGIETAESADGGQAGPIAALGVGGDWLDDFALAYSLLGTDADRLVRERGIALPLRLFDARQARLVSSAKSSAPRPRRAPAGAEVSWADLEEEMLQRAPWRTPAKRPRRLIHRQQPTSGPAADRSRLRPAQPAGPFEVTVGEAFTVEVPVRNPLEAFLALGEVKVDYELKAPDGSVLAATAHALMDAELAPLEQSVVFVPVTSTELGTISFKSISYRFSGLLPITESLQDRYSVPTAARPDKPSIRNHEPLLAQISEPIPRVTLNLGSLPTRLFHGESRSVTLTVTNVGEEALDEVYVLTSHPAHVMVGSEAGATGSAGPSLLPLPPSALVGAGQRLQPGASLDVPLLVRGDEVGGNALRLLCAFRQDGREEAYATSDVHLLEVYPSLDVRSASRPSFKPDAPFTLDLDLHNAGLPADDVVIAAVSMYSQTWRIADGDFTSPVLAWQQSAAISLEVASATASDQFDDAGDCWSVKQVQTLLEGRDVTLSSSPAPLLVQSRAGGGPAVPADDQLGILLSSYAISRRSDLRQRFTSAPAHLHPHLFPLFSATSACVTIAITSRTLGIDEQHPAILLLPIDSPQIGSTAGSKSSEELRRVIDAAQGIAGGLYAESQRERTALLAALRGTELLQSASTCPLAVQTRFPTNLKHDFSRGPLLLPLELLLRNRSPASPFSYTLRFKSSASAPFIGPLRIDGAVAALDLASLQAHVWVSRAGTFTIDGVDLLVEQSGGGDPWRVSIPPRSIRVANSSATKRDSTFPNASLSQPVEART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3G0</accession>
    <name>A0A2S5B3G0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3G0"/>
    <dbReference type="STRING" id="741276.A0A2S5B3G0"/>
    <dbReference type="OrthoDB" id="2538451at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="26"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="343" mass="37587" checksum="DA6E4053F14A9DDB" modified="2018-07-18" version="1">MLRTATTPPGSTMATQLNDILNRWSASVRVDGKVAEVFKVEHTVNKTTCYIEAIEGKEFEVTVHSTQDPGYDQVYWLTVDGVRIDGASIRRFLHQDLWTCKGKQVSQSALRPFVFAPIALTDDVNAATKNEDVLKGLGAIRLDFYRTVYTGQVANTASYADDVSNHVVDEKCKKAKMSHTTSFGAPKTTTASQYTARTEHIDPFGSPRYSLVFQYRGRDLLEAEGIIEGALPVVAPRQRSASDSPPVEIESIAKASTSTSTSSGRQSKKRKKQIELTLAESSDEDDGSDLRAKVAKVEAASGEARVKTEPGKRVKFEPGVKAEKVNVKVSRENGKVVLDILDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3K3</accession>
    <name>A0A2S5B3K3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3K3"/>
    <dbReference type="STRING" id="741276.A0A2S5B3K3"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="458" mass="51450" checksum="3B39A07ABE36E26D" modified="2018-07-18" version="1">MTRTAIHEPELPAVEGYPRNSPWSAEIDRVREHILAELATQDGWTDLGEKQGVKLAKKYREHDSNPVPIVRGETLVENVEPYAFLAGVCQPPGMRKLWDPRTEEGMMLQRYSRNEVLFYAITKGKRFIASPRDLAGIQKDYVEADGTCMIIQTSVNTDDIPEQPHMQRATLDMSGWVFKPEGPHTRCYYIFQIALGGSIPSKLVSMVAAETPLCTGRARDLYYERGHAPYVRHDVKHEPSIIFQSESFDPDLAKREYRCTVTTGSQIGETFEIAYDLDRMYRQERGVDVTVAGDSDAVQVQDDGEGTLRIKTVTAGRTLSVMLRPRTLHLLKPLPSDDRFRRIRKAFSESLEVPGTFLHPHFANSIGHPLPDNFDRAKAAAPVFASPLEAGPHTPARRLSSPLLILASFPLAVRPRINSASLAWAIFRTLKSAHTSSSIFQRPRRLSYASIAQRLSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3N3</accession>
    <name>A0A2S5B3N3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3N3"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="332"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="393" mass="44631" checksum="750649CA178FA398" modified="2018-07-18" version="1">MAELTGRMMLSSLLGAIALGASFAAFLPLIITNSVKRVNGTGPGFLVTWLLADALNLIGIIVLGAAITQQALAAWYFLADAVMLVQLLAFGHDDLTRRPPQPLKSFVRIEGRKRKPWLHAMSRQFEVFSPWDNVKLLGFCVLGGIASWGLYLTLGLYNKHDTFAIDVPEGYHPASFWLGLMAILIFSAARIPEFMSGRARSKRNEKPTHTLSDPLWWILIFENFFNLAAILTLSTKTEYLLAETPFLLGATLPIIFDVSMLFAISSWQRYWMHLDTPAARLVKEAEARKAEALDLLRTEQEDTVIEQRIRLLVAQAEVELPEIPADAQPKERRKLEARRRRIQILQADLRRNESALHVIEERLRQRKERRAHVKLELSRHLQNLELEKIEVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3Q5</accession>
    <name>A0A2S5B3Q5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3Q5"/>
    <dbReference type="STRING" id="741276.A0A2S5B3Q5"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF5">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="263"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="807" mass="89899" checksum="8250C04A013594A3" modified="2018-07-18" version="1">METLAALMPLNTLTVSLSGLSTISKTFVKHYLQRKKATEKTEARESFLYDEAFSVMRNFFKNASLSTVEEIQSFCNNFIPAPFYVRVIRVVIPLSTRLEAGEVLIEGLGEEDIENVVGGREWWQRTAHRDNGLDAEWISMKRDWEGLEAEARAQRKSKGKKGEHDEERKAVQERLEKMKADAKAREKRRRAEGKARVDGHSLSDDPGFSPEAAELLDEAAAGDERPFSRDTGDVGGSSDPSVEDTREGEDAYTSDLDEMPVTLAIHGGAYLLGSINTHRYVYWRLARKTGGRVFAVEYRLSPQFPFPCSLHDCLAAYLYLIRPPPGAKHRAVDPGKITICGDSAGGGMALALMCLLRDVGLPLPAGDLTHSFPSILENTDTDIPPPYGFAVFKPSTLWPPPPPEFRKRAAESTSLHGLKEAADRFELKETTQQSQDGPHLHMPHLHDPITHHKKEQLAHAIKKIPEVNGRHTNGGAGGAGLESEHQDSGEHKAEIAEVIRVKVDGKDVELSDQIQLYATNAQLIYPFVSPVWQPSLGGLPPLYIMGGDKEVLRDEIIYLAHRAAHPDLYPVREGILKQNTARSDRAKQYPPTKVHLQIYDGVCHDLPLFSFTTPAKYCFRAMASFAKWVTTPPGRSASTVVPDGMELPVEKDPLHPDAAGLRARPPPSRAASLMSSIRGDSARGSSTPTSRSRAPKKQRSLPQIRDLEKTIYTSTQPFNRPEYVNNMIRERISVTGVVRPMEPESEMSMLQLDKEDLGVIKEAPVKRYLDGKAVLDRRFRSTYKKVQKQRESTTCRNPSFGPVSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3T7</accession>
    <name>A0A2S5B3T7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3T7"/>
    <dbReference type="OrthoDB" id="2521277at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="51" mass="5499" checksum="50753363B0FEEDCE" modified="2018-07-18" version="1">MAALHLPRRGLLTFGVLSFAAGSWARMMYQRAAMVPRTTYAVDVSRSGGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B430</accession>
    <name>A0A2S5B430_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B430"/>
    <dbReference type="OrthoDB" id="5511466at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205:SF2">
        <property type="entry name" value="DUF962 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16920" checksum="DEED065064B41E52" modified="2018-07-18" version="1">MSDLRGKRTTVANPMYEPQAYSKSGYRSFRAFYPYYLGEHSNAICRRLHLVGTTIAVSTLVRAIIAMIPLLDKDPLHRFAALRFGQNGWKSIGKLLLGGFFQGYVWAWVGHFFFEKNRPATFKHPLYSFIGDLTLWREVMTLQRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B464</accession>
    <name>A0A2S5B464_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B464"/>
    <dbReference type="OrthoDB" id="2528519at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25367" checksum="16129A211251AA8E" modified="2018-07-18" version="1">MSQPEQVKPIEQSPMSAASAMPPIALRVPPEIWAMVHRHVRYGDLKRFGGVCKDFQKIIEAPRYGLRLFRKKPTGTLAAGTKLAIHPMLDKVNCVGQKQDIAKILLFGRGDSDKVIELNGFDFAAADEFATVPACTKMKLEMNERKCGSVSNVNGVTARQVIKAALKYWNGPVTGNVATRVRSEWQWPANHPVTRFDTLGDHRFFEGWEYGQVGADGTVTLHARWFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B476</accession>
    <name>A0A2S5B476_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B476"/>
    <dbReference type="OrthoDB" id="2525746at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="606" mass="63892" checksum="725606BC467C51A5" modified="2018-07-18" version="1">MLEAPELQPIRDARDPEAGVALSCTGIGMRPAYKFPRSQASLDLSDTNHAANAQAGPSGSVSHPSLLVTDSQGHASGLYDEQMMQQYSDAGRNMLGPGASASHHQNPAHLSASLFPSKSLSRISEYSESAYSSGSHSRDSQDRAQSPSLSYLYSPKQREPSASSYAFPTPPAHAHLAASSNSPTPILATNPVAPAPAPVAFRVMNPDDRHPDEGLSAPRKHHLPSRPLTTPFPSEGLAPTPVPLDNFAAPPGRERSDSPFNGTSSDADSRADSPVQQRQHVMVQVPSQAMVSQDPHRYSYHVPGASHSTTQTAWQSAEEDFDAKFDSRSALFNSNGVYDNASAFGADPYGGYAERNASANRFTLDDDEKVRRRKASDASAMTIGTQGWDPEREKKGSNKKVWWGLLVLVLIGAGVGLGVGLSKKNKSATHGNAQNAAAAAESSSAKDATATSLTIPTILHPSSTAIAFSSASAFTSSAASDSAAPSASSAASSTGESSASSPSPTAAPAVETFSTTFGYQQGESKTVVPLTYTIPTSFDTRANGQWQFTEQVVLPNLSGTGSFTSDLRFRVQPTTSAGATASVQRRSAPTADAGHWKRQHRSRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4A7</accession>
    <name>A0A2S5B4A7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LPPG:FO 2-phospho-L-lactate transferase CofD/UPF0052</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4A7"/>
    <dbReference type="STRING" id="741276.A0A2S5B4A7"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="58164" checksum="03216925DC48EF0D" modified="2018-07-18" version="1">MAEADSTPSTPRLAAAHQPRPTPPATATDLDALLAIQDFCIIGGGTGCNAVVGAFAGAKRISYCLPVSDDGGSSSEIQRVLGGPALGDLRSRLVRLIPPSRANSPLDCIRRLLEYRLPGGPTVSHSAVKQEWGDIVEGTHRLWRGIPGDRKETIRAFLVHFQSAVLKKAQRGFNFKKASIGNLFLSGASLFLGSVPSAVFLFQSVTAISHDSIRIIPVINTSSTVTIAAQLEDGTIIAGQSEISHPSVSSAGVAAPVVGVQEPVHGAEQDATAPLLVNGQTHHGTGLVAPLAVRTEAIFPLTRATTPSFPEPPVLGAEEDESHADLPPSPDLSLHLSTATDATGSEVGPYSPSGLTSFSANQSHNLEFTKDASAIPPLPSRIQRIFYLSTYGLEIHPRPNSTFLQAIQDATTLIFAPGSLYTSIVPCLILRPVGDLIRTTKRVRHKILLLNASEDRETTGYDAVDFVVAIQEACRASRLVGAASDSNDVPPLEPSDIVTHVVYVRNGLIRVDEQELRGLGIEPIPVGPTPEGLFNDEVVRDALAQILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4S2</accession>
    <name>A0A2S5B4S2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4S2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4S2"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10289">
        <property type="entry name" value="GST_C_AaRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="76"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="9">
        <location>
            <begin position="295"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="49277" checksum="0F98B04284E6EDF6" modified="2018-07-18" version="1">MLTRVLQAITRLPSRTSFTPARALVQSTAAMASAPSLTVTRQTPAGRAASLISAVYWTQHVQGLTVSEGEKLALGDVTSLVEITEKLSEAAGKANDALGASEEQRKEARDWLAQVEQGSWSEQEQLKAVDEKLTSKTYAAGNSLTAADLGVFAAVHPYIAQASHSTLLSHPALSRHFDHIQSLPHLSAAVSQTMSPAHVAIDADNVPLVEIKPDVKVKKPKADAAAAAAPAEQAVKPVKQVNVDKIVSDKKKGEQKAAAAAAGGAEGAKPEGKKKEKAPKEKKPAAPAPVAEAPAPWMVDLRVGKIVDVKVHPDADSLYVEQIDVGEAEPRTVVSGLVKYKTLDEMRNATLIAVCNLKPASMRGVKSFAMVLCATSPDGKDAGVEFVDPPAGSQPGDRVYFEGFSEKTALELLNPKKKIFEAVQPGFTTLETREAAWVDKESGSVHKIVTDKGVCKAPNFVGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B585</accession>
    <name>A0A2S5B585_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L45, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B585"/>
    <dbReference type="STRING" id="741276.A0A2S5B585"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="9">
        <location>
            <begin position="138"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="302" mass="34498" checksum="1DBFA824FEC8FE3E" modified="2018-07-18" version="1">MQTARIATRPLLGHAASTAPYAATLPAFRPFAPFAVQHRSYATEQQTKQDTMQELQTKQMRLVDKMGRRKQTPAILASAHIRSVCSLEMNKTDAADPPALLPTANYIPPYGGRVIPADSPHGAFSYFWHGCQQWMTSLKARMRWKKLLGSSWKAHFQERALIAYQQTNQALATGNYERLRDFASHDVVEGVKAQRTRKLQGLRMSWKLHEVKEQAILCTREQEVFKADEFIGQIAVRFVTLQSLEIRDVRNNLVGTGSHQDPQEIVEYYIYQRDMWRPEDDWKVVKRGAKETDTLADPSAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5P5</accession>
    <name>A0A2S5B5P5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000059">
        <property type="protein sequence ID" value="POY72076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5P5"/>
    <dbReference type="STRING" id="741276.A0A2S5B5P5"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="137" mass="15165" checksum="9D018D2E2683DB3B" modified="2018-07-18" version="1">MCKHILNAQVAIRAPCCRKWYDCAECHGEQSDHPLAKAHEMAFLCKKCKKAFRKDMEVYEDSDEYCPHCDNHYVIAAKTPNAMLGVESEDTRVDNRAIKDDRVAADGKIDTSELDEWLTHLDGAPGPATTGGAGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5T8</accession>
    <name>A0A2S5B5T8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5T8"/>
    <dbReference type="STRING" id="741276.A0A2S5B5T8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="737"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="786"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="815"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="863"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="886"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="923"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="965" mass="101052" checksum="D426A4292D75B32E" modified="2018-07-18" version="1">MTSSPTPPRRSSSFASSLSSSSRGGGSASTSALSRQGARLGIVTAYKDLNLHSAAAKGNIGLVQYALANGQPVNSVLDGVLPIHAAASSGSERVVRMLVEAGADVNSPRLSRRYTREGTKSSGQSVGTQGSTPLHFAAANGHILVLSLLLSYGADPRIAEKHGATAEQIAAQNGFLEAADLLHSYSLKLDQAAILYEEEHPDEAGSVSGSSRSGHARHRTGGSSLRSLGGLRRKHSSRHRHELEPMQVQAQRSFDALATKFAHHAHRAASSSSTSVNSLRGLTPFASSSQISLGATDTSLLAATAATTGLAQARRRPSLPGSAAVRPALSGSADSLRVRSSTIGSGPTPRQIATVGTWRPAEPGGSASPHEDAELAERRRSMEVNRPLRQDSMQSGLPTLASLDLSARTLGGRRSMDDPDPTPTETRVSTALGGPVSPTRPGPPQRFYRPRQSSALSKGSFTGRRPSMNEDDEHAERVFEDESPPPGLATADAPRPNRPRAVSNPDSRSPLLQQLHATQYRPPRSRESSAKNESPTAARAAAPAATTLAVPATNPSSGDTRARSNSASTDASYTVSSSSHESTWSGPTFSTASTSTAPTTAPPHSPSKRIRAPVPDVGGYFNQPLDLTNRRQLGPLYEANSPGITLGPRSAPRDDPAPANGDQSERSRPRSGKDKDALGMLTPQAIATKADGGPNVKNLKEQLAAYGKTLRAERELEANRLGKPTAGGYTFETISTSASKVRNAASPSAATKGRSSLLPPSPTRSRRSHSPGSTIQQQRSPRQGDSLTLLASGSSSAAAALPVTGPTAKTRALESTRAASPTSTRSGSKDSAAAAPEATEAPVLGQGPGGVSFVSVQPPPQNRHLHHAQHYGHHHHHQLPHGNGGSHSRNGSKTTRSSDQSQSDRDLASVNSGGAISNAPVSTRKEVEEERRRREEEEQKVPKAMRTVPGRSGFSVRKLFGSGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5X8</accession>
    <name>A0A2S5B5X8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5X8"/>
    <dbReference type="STRING" id="741276.A0A2S5B5X8"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052109">
        <property type="entry name" value="SRRM_Domain-Containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="986"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1027" mass="109822" checksum="6AE0C85CEB57DC81" modified="2018-07-18" version="1">MPATKPGNQASYLPTAAAATGAAPRAGPAQSAAPPSSDENVSLQQTQYRPGSPIRFYVERMKREVDKTAPRHRRDARRELRARPRRAKPGITLTGFLLRAATLYVLIAYFLVCPNEPNSDRAVCRALTGTSDQLRQYEPYVRPYVKQAQAHLEPYWAETHKHVRPYLDLVAPHYRKADRFARPHLATVVRLYHERAVPIVASASRRARALVQPLVIKLSKQYERSIAPSIEWYSESLSRKYAPQLAHADAFRRETVVPAFRNSLQAVRDAAESGQHHWQAHLVPFTRRAYSSSRQIYLHQVHPRVITVSRQAARVWRTRVSPTLVRFWSRFIAPQLDKIRERIFEYKLKKAQVEAAARVEKASVEIARDQERAEVEDFINDLRDEKSETSAEEAPPAYSATRAPPPPSPEEAAKLNAEKRAALEKLHAAYEQEIAKLGETQSSLLVGRLIELRQNAQDDVKAHFEGSLEKLDDEGDLMVGRLGKYFARVQASLREEEVEAKVHEADALAAKATSRVRKAADAIKAEVLAYRVSLEKKEEQAVAEAEAAVTSLVDKAQSELGQGYTWLEGVTAKDWQRYHGLRSAERNLHSRFADLRAGAITETRLETLEPYALLEYYTEQPAKLVSVFEQILEKIKVKGQRELKGEWTGVANEAQKVYGAAADKLGDFVEGVKASASSAAGYEAQPTDLAGSVSSQLGRASASASSLAERAIDAVPPPKAQSAYVDAVKSTYGDASQQVLRAVGVEPSPTDVRQSVTSLARAASASVGSVYVVASQSVVSAVGGERSSSGLMQSASSAASVVSRSASSILAPVVSDLPSSAASASSSVSSAARSATEAVGSSASSIASSESSAVSTASRGASSAATTISSAVSSQAAPSRGAGSQRVEAILGEVSQGALRAVGIEPSPTDLSQSITSVEKAASKAATSVVAADIPSRSSSSSSGVAASVSSAASSFQSAASSMVQPRASSVSSVIASSATSVARRGAAAASASASASGNDQPDSTTVRAPSRRQPSAAAKVPRHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B624</accession>
    <name>A0A2S5B624_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B624"/>
    <dbReference type="STRING" id="741276.A0A2S5B624"/>
    <dbReference type="OrthoDB" id="539398at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF1">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="278" mass="31038" checksum="703CDFE8FA1855FD" modified="2018-07-18" version="1">MGNFYDEIPTEDLVEWIKEQKMFWVASAPLDRQGSVNVSPKGYDSLEIVSKNAVWYQDMTGSGNETISHMREPGNARLTIMFHAFEGPPRICRLFGRGKVFDRDSPEYNKLLPVGDPRRLPGSRAVIWLDIERVGTSCGYSVPFYDYVKDRDRLKDHYAKLEAVDSAYLETHDCGDCTLAPASIKGGMRAYWQLKNSESVDGLPGIALAGFPPKEWAVRKNRKGVTVAYGHAANQSNWQQAVATLFGGTDRRFELGLVVGIAAGIWIGARGWQSFVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B627</accession>
    <name>A0A2S5B627_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QNG1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B627"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF1">
        <property type="entry name" value="QUEUOSINE SALVAGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="251" mass="27491" checksum="C6418DBCF8C213C9" modified="2018-07-18" version="1">MRSATPARVADLANIQTHREQDHPTLGSAVKIGIEDEEAFEVLELLAGVLNESGAVLERLDVESLGVWMRGVLGRAQGDGAAVVRELADTFPAFRDAPQVGGHDVYLFKKAFWLVSQLAIRYADAAEVPFKAPSTAGFPVFADNVLPTMLIHYGILDLSQSTDLALRQVDLAVPSTLTLSRESATRLRAAAVHACAAIVQRAHELASRGTADSKWLTTLTEPQLDSWLWTEAKREGLRDVERIAERQTVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B685</accession>
    <name>A0A2S5B685_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B685"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="288" mass="32670" checksum="72B2B7269EDB3E58" modified="2018-07-18" version="1">MHHFWQRAHAALHLTVIECLIHSPHATAALPLLAVNKHLRRLAIDSLLSCYALPSARRVPREVVRLSLSLTNPYAPPSVRDDPRFVCQQDDATKLPFHRQPVELYLSELDASSLVCTFKAKNQESAFLRWTCSYAYENHWRQLTAHVPESFSVTPTGWFRPAEPNETGLNGQMLAATPACYPSPLPCFFPEIPENPGAIIQSFDELLPNGWRISYRARRLDWIPEMLEVKSFAASASSRAIIVTVPAYCKVISLKIPFIDLFVAPDRLHDCPWADRPPQPSLTMPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6E5</accession>
    <name>A0A2S5B6E5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6E5"/>
    <dbReference type="STRING" id="741276.A0A2S5B6E5"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="420" mass="45350" checksum="FD1311E2505E416B" modified="2018-07-18" version="1">MAAAAAPRRVLIAGAGIAGPVVAYWLGRAGIRSTLIERAPDLRTSGQTLDINGVARQVVERMGLTSAIKAACTGEKGTLIVDENDRTRATLPVGFGPTNEYEIVRHLLSEVFYGASKDSTEYIFNDSITSIVETDSEAVVSFASGAPDRAFDAIVAADGIHSSTRSLVFDRDSSEVTYVPMGTHSAYFSVPSRPEEDGIWSKWCFLPGRRSIWLRPTGSSSEAPAMLANLLTRDAESQRRLKGYRHLSQVGQKALFEDFFANSGWKAERILAGLDAADDFYIQEIAQIKASQWSKGRVVLVGDAAYSPSPFSGMGTSCAITGAFILGNELAKRDQSVSQAFAAYERLVRPHVEKCQADAIGPSLANFLLPETSWGLTRLFAVLGTVSAVVNSPIKRLLALLGGEGQEDEKIVLPDYPHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6H2</accession>
    <name>A0A2S5B6H2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6H2"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="383" mass="41083" checksum="6FA08E1B8EE6179C" modified="2018-07-18" version="1">MVPACTVPHGSLRAPSQLSASLPCNSATALARSPALAVPSTCAVSFIHVTASDFSGDKDAIESSRRDQDVEAKSPTRKRVRARPTVEDRIAAGRIPRPPNPFILYRSAQYRRLSETSTSKGEKLAQSDLCKEHSSSRVLQIQRLICDPDPNCSPADRTNVAGGVAVGDRGASISALRKDASSSQHGHADYTYRPVMPPRRKAAKKQDTPALARPNVVAASGTSTDLWSGSYIAPADPNLFGPPLTAGSQSSSPPERPKTPPRNWCLFRSGLPKTRTELDPPLFCPPHEAMWPTAAHLHPELISPTAQEGEQLPVLQRLPALAATPRLLEDQQGLFMSFETMLATSPKSETGDLLVQVSALPPPDYDEGIENALQLSGLRAFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6I3</accession>
    <name>A0A2S5B6I3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6I3"/>
    <dbReference type="STRING" id="741276.A0A2S5B6I3"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37577" checksum="F0C9D8EB44DE80F9" modified="2018-07-18" version="1">MSRNEQAPTEAPPAYTATDHLQVPTAAAHSSAAETTSRHRRTSSAGSTRSSNYTTDEEHYDDSDIPEEVRRDMLDEARPLPDGWRREYDNNSQHYFYVDTKANPPRSIWSHPLDVRTLNCSMTHRGTHALRICRTCVGPCRSCGRSRRTEADERREQPEFLKTHPNVAEKLDPKAPVEESHRASTSTASHASTSGASTSSHQPQHTEEKRSFGRKMKDKLTGTTHEERVEQRRKQQEQEKKQYEAYLQRRAQIRQAQAEGRYQPMFSAPMGPYSRAPMGYSPYGGGVYGPGYGYGGRGMYGGGMYGRPYYGGGMGGMGTGMALGGGLLGGLLLGDMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6J2</accession>
    <name>A0A2S5B6J2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin cortical patch SUR7/pH-response regulator PalI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6J2"/>
    <dbReference type="OrthoDB" id="2498133at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="25744" checksum="4B023E88556F53E8" modified="2018-07-18" version="1">MVSLRLNNSPRVPSFWGPFALGAVLMLISTFSEPIWQNFYIVRGTAANTTVKVGAWGACTALRNTTGVNGPTSWCSDKHSGFDYYVELNTTGVQQFPTIADDAAILGTDAPANNRALVIGSGATSTYWLHVAAVITGGLACLSLIMKPSQLGSEQSRLFALQKSGILTILLAITACILSFVCFIVEIIVAIPARNKLNAIPGITGHLGNIQWFSLPSSVCMLVGILSVLLRSTVQHEYVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6N9</accession>
    <name>A0A2S5B6N9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6N9"/>
    <dbReference type="STRING" id="741276.A0A2S5B6N9"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="165" mass="18133" checksum="D07CB44CB13DEAD1" modified="2018-07-18" version="1">MLSTVSSTARRQGSQRLSAAVRFASSSSSSTTEQAAQKAQQAANQAGAKAQQALSGVQKTVGNLLGAYKEPIFYNAAVAREVAKQVYVGEKLAPPSFAQASYTFRQFAQQAPHPSFWRKLYESGEYKRWLIYAVEAYGIFKIGEMVGRRHVVGYKLDESRNEALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6P0</accession>
    <name>A0A2S5B6P0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6P0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6P0"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="425" mass="43656" checksum="114479288A750951" modified="2018-07-18" version="1">MAKNKKKSKSKKVADLAWCWYCDRNFEDQRVLLSHQKAKHFRCPQCPRRLNTAGGLAVHLDQVHKMGTDKIENALPGRESFDIEIYGMEGIPAADLAAWKRRTAEELGLPNPDDMKPKKPRWAQIPLTPAEAKAQLAAHKALMGLVDAKPVAAATVVAPAPPPPSGPVAVIPPPNGAPPFANGMPPPPPGFMPPPGIAPPPAGMPFPPPGFPMPLPPGLQLPPGIPPPPGMPLPPGIPPPPMGFPLPPGFPAPPPGFPMPPMPMPSMMMGGAPRFPPAPPTAPAAREKVTSSRKELKPGTVLVYGDEETSPEEKRARLVQYRVEDEPQLAAAPATAGASSATGPAEVEAVGNVASAAVEGAPASVVIGDAGESKAMQLDAGGGDPLTAEIETGSAAGASAAAASAAGGAGAGGRTRARAADLMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6T1</accession>
    <name>A0A2S5B6T1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6T1"/>
    <dbReference type="STRING" id="741276.A0A2S5B6T1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="43"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="540" mass="59737" checksum="71E16E5F6AF0792E" modified="2018-07-18" version="1">MSTYQDVEMGDESKHQGVNITSEKSDAGVVVRGVDSPEGTVHPLAEGGPLGIWLGYTIMGLVVGSMMIALGEMTTLYPVSGAFTHYTARFVDPALGFALGWNYWYSYAITLPTEITAAALVISYWRDDINVAVWITIFLVVICSFNFFGVRWYGEAEFWFSILKVLTIIGLIILGIIITAGGVPGAEPIGFRFWRNPGPFQQENGIPGSKGRFLAFWTVFVQAAFSYLGTEIVALTAGEAQNPRRNVPKAIRRTFFRILVFYVIGTFVMGLIVSPNDPNLTNASGVNASPWVIAIKNAGIKGLPSVVNAAVLLSAFSAGNSDLYASSRTLYGLACDGKAPAIFRRCTKSGLPVYCLIITAAVGLLAYMNVSTGSTTAFNYLSNLSSITGLITWACINFSYIRFYYGCKRQGIDRNEFPFKAPLQPWASMAGLFLIILVIIFNGYTVFLDGNWSTANFVVSYITVVIFAEWSREKKAELTLFRRSAVLYVGWKLYKRTKFVRLDTMDFDTGRRELDSMADEEAARYKRPTTFIGKVWDFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B753</accession>
    <name>A0A2S5B753_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B753"/>
    <dbReference type="STRING" id="741276.A0A2S5B753"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="436" mass="47019" checksum="9D5E9EE30B56090D" modified="2018-07-18" version="1">MGQDEAQQSTQEYDSSSQLPPQTDSDPAPADATQAVEQRDVDRDDHAMQHDQHAVAEGGNKLVTETEIEPTRVETFKVPGLPARPPPQVHTPSLPADMAHIVALGANQPEAKDTDARGSSTAAGGPSREIADVVKELKAKATMQVDSEMSTAARSAAALPAGTQSKGEKSDELVKVEREMEMMGVKREPASDGIAEAEEGEAQLEVDGASRQEDVKMDGNASSSDSDTDSSSSDSDSTTAAPVTRQRQRRGRNQRATSPSSDMADDDDDESGVVSSKTAPKTEHEITEPEVALPAVQKIDKAVELAKFGKVESVIENVVVIRADTGGDWRVLDEGTVVCLEDRAVIGQIFETFGSVQQPFYSIRFPAAAPPDPSVFTIGRPTFYAPNLASFVFTRDLRAMKGSDASNIWDEEVAAHEMEFSDDEEEAEYRRRQKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7I6</accession>
    <name>A0A2S5B7I6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7I6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7I6"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="187" mass="19919" checksum="E29227BE4625EAA9" modified="2018-07-18" version="1">MGSKVILQTEPVAVQRARDPAPPPAPPPYSPSVTAPPAGLRVPCSTTAAFPTDMAGPAPLKDLDGSPVWVASALFMDGSAVHPCKVARGRVMISFGGVERDHKGRYDILPLTDNMEWVTAGYGEVPKGRRPVEGGFESNGEHLYHALATIDGVQVPGKSGKHLHGANFPWSGVEMVYECGYSILCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7R8</accession>
    <name>A0A2S5B7R8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hamartin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7R8"/>
    <dbReference type="STRING" id="741276.A0A2S5B7R8"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="938"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="770"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="995" mass="108271" checksum="BA94AA021D490104" modified="2018-07-18" version="1">MSTKDTLKTLARLFGPPTTSTSTGSDNPFPDFVLPEDVNSLIDGHLRSFAASVPPSGASNSGAGQSESDKERGRWREGLLDIWTSVEPLPGTESKLGNLARVSAFLLLLHRLSADAGEDDDAALVSRRDIGSVWWTALLRRTMLGTPKNTDHSSLGPQSLVGGGLQSRTSQTRGRKQDRKGKDPAVPSPAAPASPVQSTASPLYVSRQALTCATGMVVWGMQASREHADKSDDWISPFGIAILHEYEQRALARLQGYEDEGWGVRNLEECLVQWGEKAPKAFFSRVADSLSADAPALLPFVSLTLSYLARHSTKAYYALSTPLVANLITVALTTPSAAVLTLAMRALAIFVVTLPVVIGEHLFGIMAVYGRAVSWEIVAENAEEGDAVEARADDENKDDDAVPDAMVLFTVLYGIYPCNFTAFLREAVPYLQGKEWKGAAGDGRINLASGIPLIRQYALSPALFTSDVATELTDTQRWARLEAADVMAACDRNIISAVILQQPDWRGVAPLSPSAEPQQGEQDHVPRGRTTSIPAGSFDPLMRDTPLDSASPTPKHTTPDQSPAASRAVSRARSPVGPGSSPFASPSSSRTGTPHIPPTTLYANFHALQSAGALHSPSSSNASRSLPPRSTSRRRPADPHASEHSYGWMGIAPDAAGPAAASMSRRSSGVASLGTSLGLLSPDLIPFGRGVSPTPSHPPPTQTQPLPPLSQNQVNTQLIKLETKLVVLQGEVNFQNYLKQLHLQHMGTLHREKVLESGAEAERQSSFRTIRTLRAQLRATQNALDQVRSEQAATKANWTSHIADLRDKLAALREQRMRWEHEERVLKAELEDWKDRCEKKSRELEQEGADFLDLRNQASLDASKLAKIHEYEHRIKTLTKTLAICDADLVKFVEQRKEMNLLVSEYKRSEYLREAMETESHELKAALRTLGNAMADLRRQSSSSQNNTVPAVATGKDEMSRMRAELARLRDRNAQLEEKLADVLDDEGAELAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7V6</accession>
    <name>A0A2S5B7V6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7V6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7V6"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000025">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="171" mass="19281" checksum="26238AA769EAB019" modified="2018-07-18" version="1">MATSGAAVILTRQLQSLRKNPVDGFSAGLVDDDNIFEWEITIFGPPDSLYEGAFLRATLTFPPDFPLRPPKMKFLTEMWHPNVYKNGELCISILHEPGVDQYGYEDAGERWLPVHTVESILISVISLLSQDTPDTNSPANVDAAKEVREDIQTYRKKVRRLARRSAEEGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7V7</accession>
    <name>A0A2S5B7V7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7V7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7V7"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF94">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="349"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="593" mass="63652" checksum="9EEC37F1C622773B" modified="2018-07-18" version="1">MSARSLLSEAVQLLSHSQEDLLECGPAVGHLVSRLAAATVAAVSVQPGSTTDSPLATESPSPQRRIGSNALHLSETLRDLADEKLNSYPYHAVPACWRRLYTDASLYGAIVRLANSSSRKETEREEEEADRLEAAIGRLDLAIVISGTPGPMRHDLALSLIESAQERLAEISLVALPDDGEQPRPTKRPRKRPPTVEPDSSAAIAPDRAPYIHLPLTELPALPSFLDPKHNRAHRSPFIVREGASSFPAFSPSLTSPSDRRWSDLDYLRRMAGRGRIVPVEVGGDYTQAGWGQRMMEFGAFLDSLQDVERAASRCSGAAAKDGPSEPVPPPLYYLAQHSLFRQFPALLSDLLIPDLVYSPPTHHYSCSSNDVSESPTSHPASASTAGSSPPSAPPPQGDPYVSPTTEDGYILNAWLGPRGTKSAAHTDPWWNCYVQMAGSKWVWVTPPECGDHMAAFGGSPENVAADDVAAVEPTPADIVDAVAPSVGPVPATSLPSSTADPSENTQAETPSSDSDRAGHASSADYMTNTSSFDVTRLDPTSASAALPRAYRDHVAPRARQAVLREGDVLVMPPGWWHAMVGLETSFSVSMWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7X0</accession>
    <name>A0A2S5B7X0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4114</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7X0"/>
    <dbReference type="STRING" id="741276.A0A2S5B7X0"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="162"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="364" mass="38323" checksum="B342F94CEED5AE17" modified="2018-07-18" version="1">MPDKRLRPVATAVPGVSIWYDFVTPAEERYLVEKIDAAGGGPLNAAAAAAAAGSDATTDTADSPAGTADAAVTTQQRDGVEAATIDGTAGSTPAVRKPSGWKDLNGRRSMYWGGTVTPSGSLVPAPFPTFMDSAWPNVIDRIAETGVYDEWTGGKGNGKDRGPNHCLVNEYLPGQGIMPHTDGPAYLPCTSTLSLGSHTILHLRSKPAHLASTSSDSAVANGPSSDASAGDDRAASIAAVQKIDLFLPPRSLVVLTGALYSDWLHGIAPTGLDTVESLVACANWDDWWRYQAETEADTPASTEETRGLPDASPSSAGQSTKERRMVEEGKGWERQRRISLTCRRVAGKVRNLGGLLGLVGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Z6</accession>
    <name>A0A2S5B7Z6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Z6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7Z6"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="50"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="221" mass="25377" checksum="1A0EADAC5B1C7153" modified="2018-07-18" version="1">MTHLLPEKNAEYGTQEYWDERYAQEADDGSFDWCKTYADIKHLVNRFVPDKNARIVMLGCGNSTLSRDMYDDGYRNIANIDYSAIVIEKMGRVNADRTGMTWTVGDVRNLPFEDQSIDVCLDKATLDAMLTSEKDPWNPPPQAVADVKGEIDEVVRILKPTGLFIYFTFGQPHFRKPLLQRPGWTVQHLEVGDGFAYYWFWMRRDEQPDPPALDAGGKQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B814</accession>
    <name>A0A2S5B814_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B814"/>
    <dbReference type="OrthoDB" id="2522990at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="152" mass="15893" checksum="60E9A49A5485DC5E" modified="2018-07-18" version="1">MAIARTPLHTAARWHYARLLCTPLALAGTDPTAPRPALVDRATVLQLVSRVLQDLYGTMGGPIGLGEVDVAAIEPSAFGGSEVVIRFPAGATHALLTALPLATLSPFRISILRHAADLGQLAGSAGRGARGYKGWVARVLQAQPDQVPMQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8C6</accession>
    <name>A0A2S5B8C6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8C6"/>
    <dbReference type="OrthoDB" id="2522885at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="158" mass="17259" checksum="CEC64A9018FA9304" modified="2018-07-18" version="1">MAGGVLNKIEHALHLDDRTRDLDTVHASTHVARDQHEAEERRADALMIERDAEQRAHPETSGPPGTVPLAAQHDNLSSMPHRASLDEAAHGDHAHQHHAERQTTPDMEGVAHVPEKDLPQRYDRMEGTGLRPSDPNDVHSMDGKPLPLGASAGDDAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B933</accession>
    <name>A0A2S5B933_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B933"/>
    <dbReference type="OrthoDB" id="2506625at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="561"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="660"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="767"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="820"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="882"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="917" mass="99811" checksum="269259F8D2F8E567" modified="2018-07-18" version="1">MNREYGSYSRDYAALVKKPVVYETLPNSDIPPQRQRQAVPIATPREGSTHWPSSSVTNSVVGVAQFHSGPAPSSGRYGDSKPLTRQNSQSNANRGFVSNGRNGGDVAVLTDDFGLGPTEMFRGSGTAPKRYIETHLEEARGKALTKKGRTGAPSSHDSPYSMPNRSSPKRRPGSPTKADQVAEAARKEEQEKELEYDRFEARAKANKAAALDKQEQLRIARRAAAAAADQDAKDSVRKAAKPGNVFDKIKQAGKMQKSKQREETTALAARSPDKKRKIDKGKSKVVQLDITDDEETSPRRKRKGSAEKKKHSSPPKKQSRLGGARRNGFEDDESTTSNRQPSKSESKTKKAPRLRQIDSEEPSETDEPAERVVPLHELLQEARVAKDATAGETPTKVESTSDEEILGVNGSPSSPARRLGYDARFDSPEKLFVPTQAAVDPDTLCPFCDQPLPDQPSEDLLAKKATLLKDPSAKRRATIKNPKAVRLRDGHVMRTAQFCKQHENERKHIPLGRERGWPSSINWAALPTRIERLLRDHLSKIVLGQTHTDFLEQARNDYERLGGKRSNAVDDFATFNVEEPGYYGPEGRRVMYHAIETLLTKTYPLLTAFRTAPLDIDFYIRRVLVPECGVELIRDDLGGAAQTSRDDAVRVMQESRGYGKAMFPDVGGEAEGARREASQAPPESSPTNDEPKSQGRRVAIRISSSPSPSPSPSPSKNDRKSRTLVTVTSSPHVSDSDDSTTEMVRTARSSPPPATKSGAGGFRKPKGFSSSSATSKSTSSGSTVFKSSKGSTTTAATTLFESDVSDDDDCDALRPPPSAQPSSSRTASSGLSGRPRDPLQSTTSTGLLAGMRIASDASESESEAESVDSLPEEISTGGVAKNPKKDKARSKKTGSTSSKKRKSPKKAKKTKSPKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B972</accession>
    <name>A0A2S5B972_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGTA homodimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B972"/>
    <dbReference type="STRING" id="741276.A0A2S5B972"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000207">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="6">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="345" mass="35191" checksum="6589E325C68F6F18" modified="2018-07-18" version="1">MSSATAQKRAAFSILRFLDESLKNGTIKADDAEGIEVANQCIAEAFGIDLDAEQDQRAYGIAKSLDQLVQDAANQAGSSSAAKEVPSAAAVDKQGAEAAKSRGNQLMAKKDYQGAIDAYSEAIDKDGSNPVYWSNRAAAYSQISQHDSAVSDAREAINVDPSFSKAYSRLGHALFSVGQYGEAVEAYEKGLELDPTNATMKSSLATARSRAPAATSSSSADAAEGAGSVSPRAAGGAGANAGGAGGIPGFPGMGGGMPDLAGMMNNPAIMNMAQQMMQNGGLERMMQNPMLQQMMGGAGGGGMPDIGALMNDPEMRRLAEQFGSAMGGRPGGAGGNSGGNSDMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9H9</accession>
    <name>A0A2S5B9H9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9H9"/>
    <dbReference type="STRING" id="741276.A0A2S5B9H9"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="315" mass="34346" checksum="5474D00E98C6B812" modified="2018-07-18" version="1">MPTRILVTGATGKQGGAVIRALRSQPNAPTLRALTRNLDSPRARELRQQGIEVVKGSFSDIESIKRALTGVSAAFLGKSSGLYVSMVASKNDLPEEQQGYNFIEAAKATNLPFLVFTSVSDATTTCGVHHFETKARIEIALRESGIPHAIIAPSALYDNFTRRHSWANFGALGVFETGLQGGKVQMTAADDVGARIFQGEFAPIDLADPSLRVQIGEIAAQMLLNSGTYAGRRIDLAGDYLSMSEVQRAYSAVEGKPVRKAAVPAMALKLLPQDAQQMFRWFRTDGFTVDLDALRKEFPRLRSFEQWLREGEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9J7</accession>
    <name>A0A2S5B9J7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA replication complex GINS protein psf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9J7"/>
    <dbReference type="STRING" id="741276.A0A2S5B9J7"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="104"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="250" mass="28137" checksum="D1DAF6A3606D9FFC" modified="2018-07-18" version="1">MSVHPSRRRGPLPSDVEFACLDGASAGWSRIEQDLQRRAPNAKGKAKEGYVEIVPSVRMPVIEGLDGRHLTYGPLVPPQKAWVPLWLAVHLKKKRKCRIVAPHWMTVAYLEDTLKAEQTNGEFSDLPRDYLEVSKVLLETAPDDLASPDRIRLLLKDIREARQAKVRDGLGAINPVHLGMPNISAMEIAELRPFFSLAFTRLKDLDPQAEQHRETEEWWMRDPGGCMDAVRTGQLRNEREGTAMSAFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9L0</accession>
    <name>A0A2S5B9L0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9L0"/>
    <dbReference type="STRING" id="741276.A0A2S5B9L0"/>
    <dbReference type="OrthoDB" id="3219336at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047126">
        <property type="entry name" value="RNF141-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109">
        <property type="entry name" value="RING FINGER PROTEIN 141-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="147"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="37"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="456" mass="50899" checksum="D3C88D409E90EC00" modified="2018-07-18" version="1">MGFSEFIASAKDAIIPPAPPVPPKTEADLDRSKDEVIRRLTQELVMTRERKHDLERRQLQETKARKEAIERVRELEDVIALKNGMFDSLERQLELLEKHTAELQRKEAELVALRAEQAEQPISANDLAHRFEQLSDLFTQLQDTLTCPVCYEPFGRGQAVSLQCGHTFCQTCYTEWEQRHVEAFKNSPRQGVYTGPECPECRTADVRRGRVRIYSLEEVVRLVERGKREIAAHPYTPADIKPIEPITAAQLLLQEQDETQDDPRTDLDAVEVSIETHAPVAAETKAVERGNDAKQSESTVFDGTIGIIDATPPLLDPPPISEQSISDVQAAPSPEAPMGPSPGAPSSPIYTRADQSDEPDQPHPPPQSIAPPANTDAVIAADIVLPDASRLSLEETYLRERAAARLRAREEELRLETEAAARRAEEEEREAREAREQVLAERGRRPYAVGAVGRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9S4</accession>
    <name>A0A2S5B9S4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9S4"/>
    <dbReference type="STRING" id="741276.A0A2S5B9S4"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="818"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1011" mass="108043" checksum="C0AEEB2484F96456" modified="2018-07-18" version="1">MSWLDALAEHPVWTLPRPEQPADDAIAPGGDDQRGPLNGLKSTISQSQSSQSLFGSTTARSGPSPAARSTPPAAHNNPASPRKRTLTPAGATEHERRLRGTRTSSVAVVRGSDLVVAVGSELRIASLAQVKANTGADYDGGALGDHDVGEYKILHTPGITFEIQQLVLNPTSKLLAVVGAHSVVVVVLPRRGWANAVGKVIECRCLPIGAFYHSLPGSPAIASALWHPLGADASSLLLLTTDCTLREYTVSEDVSEPAQTLSFSRSSGPDADDKKGKAAGRGAGAGFGFSAIDRDAKTAAAMCIGQGKADWGPLTLYALMRNGDVVSLCPFLPKKAAVSPSFVHALSAFVSTKVDYLSSSLSASLNRTVTHSSDAATEARRLELLESRYNLQLAYVQSLSRQLASAGKARALARHGVDAEEARLGDSVLGAAGDEEEANQDAPVRVTAPSRPNLAARVQGPFLLQPAPAELDNGADDRAVDIAYLSTEDLMAATPSANGSPPAGAGLGVLVVAYRDGKVDVCLEVEKPEARFVGERSVPKAASPAKGAVVLRRRGFGAAAFDDDDDDGEDEEKDGVTDEDELDLPTLAVYESIDLGLAAELNPHSDDESAVRTGLRHNAPRLVRDPLYADTIYVQHALGAHCLLLGPWLDDLAQVMSDSKAEDEVARILQQSQGTEVLWVLKTQASNAAERRSTPTVDGLVVLNDVYLGYSLLLVTSALQLVGIELSLRVDETAGGLERTKDDAASGDAAYVSLLEKPFSVPPMFSQRHPGAPPILPRLPSSKKALEINPETLRAFATHVSSTQTAIRDLVSAADSVQSRLELQMRELSRQVEKLAELDRMRDELGKSVSGGTEGRLRRAEEKQRELLARTDRVLQRLVESHQPSISTYERKWFDELRRLEEQVAGRRPAEGDDDDSDGAADETQATSLEMRAKRVEAMFEALRPGLEELKRQNGSRSVDGTPGRRPAVSLGQNQVKILEERLSEEARLLADTKRKAERLAGNLSSITLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA01</accession>
    <name>A0A2S5BA01_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA01"/>
    <dbReference type="STRING" id="741276.A0A2S5BA01"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="504" mass="53871" checksum="0EAAA27C1A517053" modified="2018-07-18" version="1">MLERLSLKSGVRRSRSSAASATNVGRAPFLLRIRSSTWFIALAVSIGILVDLASYSLAVPVIPFRLERLHYHRVGDKTGYLVAAYAGGQIASTPLVAYVGARWRNRQVPLVVGLCSMIIATIIFMEAKNFQLMIVARILQGFSGTTLWCIGLALLADSVPEERIGSVLGVVLVGFPIGQAIGPPVGGALYDKFGYRAPFIFMLILVGVDLLLRLLMIEKHAALQYIRAGHYIPNFEAPGYVDPLTSSTSLHDLDGTVSKNNASVDDMALFDPDTVPLARAEMDQGPNDLKSQFIGYWHMLQSPRAMTTILLTLVNGFVAGGMQDTGLTLYLQHRYHMTSSGAGLVFLGLVIPVFFASPPAGWLSDKYGTKWVMLGGVVLSIPMFPLLIIKVSLPVFIVLLSVLGVAIASFVTPTTTDLALVAAGSTSIKTAQIFGVFNLAYSVGALIGPVVAGGLLARLGVMHGWIALAGLSAGLTAMLVPPILIFVGGPLNWHRSDADKVPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA58</accession>
    <name>A0A2S5BA58_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA58"/>
    <dbReference type="STRING" id="741276.A0A2S5BA58"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19490">
        <property type="entry name" value="XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44155" checksum="1D2719DB06944A90" modified="2018-07-18" version="1">MDRRLASGIRYESALSLIASVRRSTSLPTTFVTGLDSMLDNAGIPLHRGDVVELQGLPSSGKSTLLYYLAATTVLMRRAHVRVDRQILEIPIGGKEETVVWIDCTGRFDVDRLATLVRHQLVVLITRYRAPKGIGAPRDSEIDALVEECLSRLHVFSPTSMLQLAATVHHLPDWFKKNALDELGTVLLDGMSEFAWLEQYEIEQKQADVAAGSRPAHAATAATKKPSGQPPLRLLCAAVAHLRRTLAPLIFITQWVFRPWSVLPQLSQDGLPFYSHHYGPPDWPSILTPDVTPGATDDSNDPLDSPSLVDGRWPTFPLALHITVHPRRKPTFRKGVRFDEVMADVRKSAREREKALKGQGVGTARAAGLGTEGITCVVRRPGGIEVGSWDMSIYEKEIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAP3</accession>
    <name>A0A2S5BAP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000034">
        <property type="protein sequence ID" value="POY73839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAP3"/>
    <dbReference type="OrthoDB" id="2529759at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="488" mass="51795" checksum="BD2B9214C9366549" modified="2018-07-18" version="1">MGATARTTSPEPLSATLKHVSFHPLALRITTAPEGEPEQAMVVNAAQEMAQRKRRVGVRTYRLPVPSLASPQADVDSKRSWDTPQIGDATSKAWHSMLNGFSATLEPFLNSSSPAAAGGVCSQTRMYGRDTSPDRSLSRSRSRSVGSSPGRGRSGSTSGDPRTDPSAPEFDPAFTPNSPPRLRLKLPTIKRTTSRIVTDSGTSPVSAGGCVLCPRSILRSTSSPRTASASSAHCFPDLARVASPPPPPYHEPTLPACSDVVPVLPCCSDCENATLYGSKATLDDSYEEHWSRGARRMRQEAEKREAARAEWKKTADEMGERYRCPIDLMRRGSALGVHDEDDDALTCPGNRLGELVKERGHVDELAPKRGRHIEEGDTSEEANAPLHEAAEAVEPAAESVAASASADPPLPSPKPPALESTPATPAPDAPAAAAAEKLASTLNTRESAPPARPPARRRFSSSLSRIAASLGTGLLSPPSNTNTFRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAQ9</accession>
    <name>A0A2S5BAQ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000034">
        <property type="protein sequence ID" value="POY73847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAQ9"/>
    <dbReference type="STRING" id="741276.A0A2S5BAQ9"/>
    <dbReference type="OrthoDB" id="5576441at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="73329" checksum="934A547D9D8C6E08" modified="2018-07-18" version="1" fragment="single">DDSDSSDIIISTVTRPRAGPSSATSSEAAHVAKRKPAATLDFLPPPIELPPDDRLRALTSCALCSVAWPASKALATRQKHVRSCAVKLDYTAETVRYLVDKQILELAEAAETERRAVDDAKTLFDRAVGKGEGSHAMREVTVVGVESLVHASMAEWNQATRALQRELDASRRKVQVAKVIMIAKQIRQERSQVTANPASGPAAGAETDSTSSALEVELPPSTGRLMPASTAVASLVADRIEAVLGLAASEPDDPFASPPRPTQQFESSRIAQAQAGGPTKPKNDGDYDDTAANAAGPTTADMRSRARSPFRELSLPDPRSGSIPRQGHSISSVLGNRTLVPESSLWHLAAGRDDARLDSVVAYSASLASSRSLHTSPLSPTWDSPRSTRLADGMKTLGLHSPESPSARAKREAMDDWNEDDLLVGGASKAGSGGGAVVDGSSSSSEEEPLAAVVERTSPKRRRRRSSVQSDSELYIIEPSPVAAGQASTAPDDPPGMPDYASLAVTTLQRKVRQYGFRASKEKDVLVAQLRQVWNAMHPVGHDSAGPAPAAPKTQTAGRTKAASRRKKKVDADTDAEDAEEAAAAGAVSGETVGEKLRALIVANDQLYLRILRYEVRFSANLTVLFIRLTLSLLRLQPVHIDEFATLAADNGVKIARPFMTRFLDEQSITHYSQDPTGGTRRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAR1</accession>
    <name>A0A2S5BAR1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAR1"/>
    <dbReference type="STRING" id="741276.A0A2S5BAR1"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17185" checksum="57939D3D80BA6FEB" modified="2018-07-18" version="1">MLPHELCSRISNASMARHRWVPLAPTNQHLSLLSLLLSHGFISSVSYGSTNTSAAVAPDPQSYASARESDKRVWAELKYRSDRPVLNKMRLVSSPSRRIFMDKDEIRRFVRGSRVKFVPGLGLGEVALVKSNEGWVDGREAVRRGLGGEVIARVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAT5</accession>
    <name>A0A2S5BAT5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000034">
        <property type="protein sequence ID" value="POY73841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAT5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="460" mass="51607" checksum="5B5085F7BA950A97" modified="2018-07-18" version="1">MALSIKRNCGMSPKPEVVKDVLRNSNRECRTVSLLHLPNELLLQILEHLCRDFADNDHGRPTAGPTIDLLLVCRRLYPLAVSLRLRKIRLKGETTDVDSILAYLIRTLGAFEAVHELEVHLNSVVEYDMVLPAILSRLTHLCALRIVDDPDESGDDDDDDLADSWCRIDELLIRCSNLRYLELDPARLVDEVDFATCVRPIRHLAMNAANNSLRAVSFLQNAQPTRLCLHVTASAAPPELAWETLQQLEIEFAPGLAGLPTAFLTTLRNVLYSRGGNNIALDLLAITIRTTDCDLNELLLRTRLAFMACNIGKLLIRSIGRGFDISALPWVWPTLRTLELAMPHTGISRRLKSFKHSMKALATALPEMPDLIRLTLVNVNLSECDCCAKPTVDRLLAPEVDLSLDFPALHVFLQHLVRSSVLDFRIRTTASAESSELGVEARCQRTTRSEEFTVERWTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAZ6</accession>
    <name>A0A2S5BAZ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAZ6"/>
    <dbReference type="STRING" id="741276.A0A2S5BAZ6"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="477" mass="51769" checksum="E208274744D7E0AE" modified="2018-07-18" version="1">MAFDDSTLTTISPVDQSEVVSRQYPSSNAHLDHVIASAHAAHRAWRTVPLTDRIALVHKAVDHLASRALELGPELTAQMGRPARYTAAEFATYKDRAVWLLNQAEAALKDQSVDQGRPEGIKRVIRRAPVGVCLLVGAWNFPYMIQVNALIPALVAGNSVLLKPSPQTPLVAERIQQSFEAVGFPEGLVQTLHLNPTQMDYLVAHPLIPFISFTGSVANGKRVEKTAALASAQEGYKGGFKVVGLELGGKDAAYVRKDSDPAYAAENIVDGAMFNSGQSCCGIERVYVHESLYDQFVEEVVKVVKGYKLGDPREQETTLGPVVSLRSAATIREHIAEAVSKGATALIDESAFPLAKEGTTYVAPQVLVNVDHSMKVMSEETFGPVMGIMKVKDDAEALELINDSPYGLTASIWTKDEQAYAALVDDIDAGTVFMNRCDYLDPALPWTGFKDSGRGISLSRYGYDAVTKAKSLHIRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBN6</accession>
    <name>A0A2S5BBN6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBN6"/>
    <dbReference type="STRING" id="741276.A0A2S5BBN6"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015548777" description="Aldehyde dehydrogenase domain-containing protein" evidence="5">
        <location>
            <begin position="33"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="331"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="612" mass="65505" checksum="02492298E2454CFC" modified="2018-07-18" version="1">MDGIAPSDTVAVEVLLLVAAAILLCFVSGAELDSCSATRDCKMTEHLTLDGWLGLFGGGGAAAPAVGQVLPPHIRNPRPLHVKSPPPRANDPAKSSTHTHRPKSIANHAMNDQQLQRRLRVLKATATDGTVAFPRFQQDQLVKLHNVLVNSRTELVAALRESCGLAETEALIEVAETLQQIKSFGVHKLDYAKWKKRKEVQLRTEGTVEKGRGVVVITADAAAPVYSVFVPLATAIAGSNAAVCLLATLPKMLGAVLQSKLYATLDRTAFLFDVVLSADATLQQDWTPLRPLTISRASISTPPSLCAQAGTSGATVLVDRLHRTSPLLHSIARLVVRGAAHAGGRLPGSIARVLVHEETAGALVDALLAQLREAYGADATLSNDLARTVSVDEAEKLALDVRRETEKGAGRVLCGGSLATKSAAGSVFPPTFIENPSRDFLGRNLAGPVCSIATFGSSEDALYTLSQIDSQALYAFSDEQETLEYLAVETDVSAFWGNDIPLRALYDPHGILSEVSHYQKKVLYVAPPKASAVLATSLFAPFTPSRRAYLATLLPRAPLSLKRAKFSNSILRVFFLQGVFLTVGTVLSIILGSTSYGLYSLARRFLFTRSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBT3</accession>
    <name>A0A2S5BBT3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBT3"/>
    <dbReference type="OrthoDB" id="10455549at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015529107" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="19108" checksum="DCAD964276BEC907" modified="2018-07-18" version="1">MVQLAFAVAVLAAVAPLAIAKGPARLLERQSQTLGGEGLAQVQGLMDLATNVANDIANGNASTACTNWVNALQACSPDGSTANASAVAVCACGSNVVAQLTSCAPSYGSTGVSEASGFSTFCNSALASLVNSSLPLASASGISVAPSSASSGATSAGTKGSTSPSGTATAAGASASAKSGAGRTLAVSGLSVGLVSVAAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCC4</accession>
    <name>A0A2S5BCC4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCC4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="397" mass="42570" checksum="8237AFEFF2697B3C" modified="2018-07-18" version="1">MTCAGPEDQLASPPHRVTLSRSTSSALKMSVPSHLEDSASILSALGYSRPNVGQTYDSQLAFKIAATASFLKAGVEPAVDAHGHGKKLVMRCRLRKDSRCEWTGVGAPCEYSVAAHKSLEGPDRLEVKQVNKRHTCSKRIRSARQEASPPSTKSGAGYTRQKLGALLDELRMERKGAQKPRSEVAPQAAAASPVESSSESDSASCSDSMSAVRPTRSCAKGVKYIFQPPLYKPGPSASTQQKPHVQIPNPIGSGRQRKKSSTIDKASHRNPKPWSEPQRKKAPRRLLMTTKARPTAAAATSSNAAFRLAPVLRSGTSTTNVKPGLVFLDTEQQRKLGAALGHAGVQGPADFARLSSLDDSTLARFGEGLAEDETDWHETEHFPTISTAFAAFVSHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCD7</accession>
    <name>A0A2S5BCD7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCD7"/>
    <dbReference type="STRING" id="741276.A0A2S5BCD7"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="419" mass="44668" checksum="3F2C9D2B5241F2C5" modified="2018-07-18" version="1">MASLPELPAVSSLSKYVTRVLGQNPSKFTLQGTNSYLVHHPHSTRMILIDTTGPSSSGPLPAGSLSNYLASLRSVLVPSPSSAPNSAASGEASESRQRRRRYISDIILTHWHRDHTEAVNAVIGLLSELRREETERGGEPQTPPVKVWKFPCAAATSDRAWAGEKGRDDALENELGKLSDSAIEPAANGGPLCGPLEPGQRFQLSATESSSSAPEHVDDFVIDLQVVHTPGHTSDSVCLLLHETSTSASSAAARPIGVFTADTVLGHGTAVFASLSAYLTSLSSLVSVLEESESSTEACSPIPLFTGHGDVVHDGVSKIKEYRAHRVERERQVVEALRAANGPQTATELVHQIYGSTIPESLIPAATHGCLLHLAKLLEEGHVDRISKGDEEAAVAVEHEEMQIPPGWHDGWAVKVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCI5</accession>
    <name>A0A2S5BCI5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCI5"/>
    <dbReference type="STRING" id="741276.A0A2S5BCI5"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26868" checksum="05734C278E0CD628" modified="2018-07-18" version="1">MDRLAQCLKTASRTVPNRFAVRSRPSARSFSSSGSRTASSSTPSTAPAATQPYPFSTAVHTFTQAAEQASATSAVRGDSLLRTLNAHLSSQHPRADSYLPLFSRRAEDRVRPGSVLTVTSYATAPTAENPTPATTVFSGVLIGIRRRHGGRDTSIRLRNLVGRTGVEMVFKVLSPLVKDIKVVQRAETSGPAVVAKDGSTSGPRRKPALKAARRAKMYFVRRQPDRLVSVAGIVKQAREREANQSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCN5</accession>
    <name>A0A2S5BCN5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCN5"/>
    <dbReference type="STRING" id="741276.A0A2S5BCN5"/>
    <dbReference type="OrthoDB" id="2630497at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044251">
        <property type="entry name" value="LHP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47240">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN LHP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47240:SF2">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN LHP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="41"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="813" mass="86708" checksum="B593923FFCF6FC0B" modified="2018-07-18" version="1">MPRSPESRLVAVTGPSRDADDVHSGSEEGSDAAEGEEEEVYEVEAIHASRWDDQAQAKRYLVKWKGWPDADRTWEPVENLSNCIEILNKYERMKAERKEKAKKKAGSAQGKATPANESVEKPPSNAKLPAKPASKSKPRAKAAAETSEEEEGGSLAELDARRDQAKKKAKMDPRRLSQAVRSEDAVAKKWEEKAAAKEAKKPRSSAASTGSASSKRKAASPPRPARKPAKRPPEEDEENKPASTAPKKARRFVASESESEEPARPISGPAATTTGRPASTVDPKAVAASIEAHVAAAQTNSAASPAYTSIDPAAILLQAHPKQPSAASSESIQPSRIVKANDATSQQETMAKRPSGPPAPWAAGGALANLLNRSFKAKPAPPPAPAPAPATAVDDGAGSSRVRFAAAPTVATEAIRPSGRSISPPAHPVSAMKNSTASMASPAYTAHRAASPVVVGASSASIAAAAAPARQPAANVAAGDENGANGANSTGGSSSDASPPHGVAQTATAKASEEEPRRTRLRDMEIRLQQSSWYQQTDIFRTEELVVACAEAVPVRSDLGLRLKSKAVAILFSAGKNERMSGEGLALGYLLLAIGSKTPTQMSDLEALFLHRDEGFKQLQALYCELVKLDHTVEFFAFGAGREIEPILGSGYLVLPSMSALQLGAAFERYCDVTARAYGRTCQTIVHPATIARARSLPNSYRIISGIQEQNIHVIRRENLRLQSGMCTCDTSDLLQLDVLPSTAFPKYTFDEELDEIFQHLCYARAREPTAWRRFVVVVNEADPIVVERGRVLGIEVHTWTSLSALVKAHPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCV0</accession>
    <name>A0A2S5BCV0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCV0"/>
    <dbReference type="OrthoDB" id="3366139at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="646"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="753" mass="79889" checksum="48462606447B59CA" modified="2018-07-18" version="1">MSRASTAARDSVAAVTAPPASASPTKRRRLKLEGETSSHAALAPPTPPSSRSPRKRTTATQQPPASPSPTSSPARLLVKLNGRVYRPPSPDDLRTKREQEADLLIAEPVETVADLEASRREEKRKSVEDQMRSERLKAAEAGRRVRSSKGRQEGLVSPQRTAGRLLRFDSDDGIDVTGSPLGREIARPSAGLASPSRQRAVTPPPTRANASALSPALGLPFQPTSSPRRRPLPPHLASLLALHSAVERTLILHLSTAGSSIASTVSETTTNTEDGSTTATVRMTNLIDLSTLGRMLESTGKRFTESELRRLVWVWQGAGGSASSSAVNALASPTRRRTDATQMTDRTASVVLGRDSDDEVGGMGFLVTRARTASSSTSSNGSSSLFNASGARVSHTYGIGIAVAVKSNPQLPKLELVSSSSPGRKAGSAYSESMGASMATTPPSPSSVGKGRDGMSIVALWTQGKELRQKEVERRLRAWADKQVKVEPEDEPDVFDSTPAVPMVPLAALPLLSPAVPAIPSTSTPSPRKRTSSTSDPFASPSATKRAAAAGDNAALPVVSPEKFVETLLAGKPLKSKAGKAADRERALRERIQAKQAAQQKSAYHASLSALSTGESSPTKRSLKRHGPSSGEDDLGPESGEPVITMHEVRKRNAMLSRLGSVADVVAMRCQGRPILYEEVCAAISNSPLVSIGYDEADSALTFLAEHFPDFCYIKLVGSEPWLSLRGVQRAVEVKELVRQQLARAAAALDATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCX1</accession>
    <name>A0A2S5BCX1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCX1"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="1661"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="525"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2009" mass="213934" checksum="028760BDB2CCFD74" modified="2018-07-18" version="1">MASNGHSTPSRGSGLPTTQPSPAQSSPATQASAQEALASNARRIIRAWPVGAALEPRVDAISHLGPIHSAYPSFFPAADGADELAQAGLPADPQLAQFAPDFAALFASSGLAGNDDTVRWRASQVEAVLATEEMRQVMRGVAADPEYGSLPPLRPPYSVDSAAQPALAIDSTSLAALFLSTSSFPSPRPTAHAVPASNPLQPRHLKSQAADSSAARTVLEGLVRETSARARNEAAQAAAAAAADAEARRRNSMDRSSSMMPLTPTHPRTSQLAGRPAQLAPTSSPDPLMMRSDDHEPAAHPTTRAPTSQHARLGGSQSGVANIFGTQILPNLPRKRSSSTDLSSHFSSPLKSTSPVKAERPEGEMTPMALEPGFESAVKRVKLESGKPVNNSTGGKAAGLEAVERFGDLVSDVFAADDAFIGDTSTAALSNRSPARSSKGPRFFRSTAVGATSGLPLVHTDTLKRMLALVRTITAKRKTEELLEEVEASGISRTLKLLERSWEGIASEGWEGWSKDAAQVREEAMTVANGKGKKSKKGSPAKGAAKGKGRAKATGRKSATPVTGAEDEEFKAGDDDESAMATSSPLKGPIRRSTRSPSPRPGSAIPPAAPDDSGWQDDGADKAYWNDDRLSQTRAALRDLTDALLAARLALELLTLPGIVLPKQLFSSEFLLGLVGTIRHSLDGFFVPVLTAPRTSPLDELAVDHAREQVAEAGDALVQGVHVLAELVRHEELSEDLVVALSYLSLEPFFHDAPPVAGRGAAAASDISPVATAIKSLRLVALAVLQSVYARYTDQQTWIVEEVLGNLGKAELVSGGSAAKKAKSGIRIRTGATIQTVSTLLMHLVQTCPVDLPTRIRKRFARAHRRDSKQMSLDQDDDVLMGREGVPSRLVDDGEGDEGDGDEDVLVAVHQRFVAPAVEAAQRTARTIVGFLMQRAAKAGKTSGVAADTEYRAVLDVLVTDLLATLPLPEWPGASILLTTLCRSMMATLADSKTSHENNALKALALDHLGTVTAHVRRLIADSDDGLDSLRGIVAKCELDALDRVADAYRAVLEHLKSQQAAEADQAVSRFRRLDYANDLLQALVAARLLAASPEGGSMIARLEELSEAVWTSEPLGDVFGPGPDASQAAIDEVSLKLWRTSTLATMYRALVERVLDAAESTQITLRTKAMRAIGNIVAQDPALFHEDSVRRGIESRLLDASSAVRNASVELIGKYVVNSQELARQYMPVICARIADSGLGVRRRVIKLLKVLFNVLEDESARAEICRKIVCRVLDEDEGIKELAVDTVEELWFDSTKSGQPAETEQLARIITLTCGSAEERPPPVDEALRLIMAKHAEKGTPAPLERLQQVVEALVDNLVENKTADTDLVAGIKALHVVGAVDASLLSTAKATLLLPFLKSATTAEERAITDYLLKLFRGTVQAGARTNSKFGQELQKALVSMLNRPASTVSTLNDTIACFCATVHAQTQDYDTMTRVFKVTLVRLNNETQKLSAPETATGVNQRSVPVLCYMSALLCEHGRFDEVREQDEEARAIIDELSTHPIAEMTFNLLIRLYNLDVQPAIKGAVLTSLGFIYRAHPALMLRPASTAIIDAIFESAAVPPRLQILRIIQDFLSSQEQAQAAAAARSKASKKGVHPVTIEMSELVGNVEGFADSGVASAVSQRYLKRVNEAAMSEHLALQRVAVDLLSAIARSGFSHPITISPTLAALTASSDAQLAGKAFSALAVLHQKHTSILASRFLDSARAVFAYVQAGTPAGQAVRGHRLSSEGVPDSLLGRWYSLLQKEKRQIQLDCLKALGRAYDVEVGSHCSTDAVAFARFLAEALSTLEYKRAEEPLMVIAQLNAGLAVSGLHVLHSLEQGLAGGGGLIARASASPQKLPGGRGSSPAGADELPSADLARQSIVCGLALLLRDHLKQLYSLTDAKIAKYVPGKKSAAGDKAVTVRAGATTALGSDDYPRMPHALLPLTNAADLTAQRTIYMRLIADDGTLAALDELEADGADTQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD19</accession>
    <name>A0A2S5BD19_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD19"/>
    <dbReference type="STRING" id="741276.A0A2S5BD19"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="866"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="866"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1022" mass="109484" checksum="7CD0588A5422B37D" modified="2018-07-18" version="1">MSQYTHYPSSSLPPYGHAPLLVAPTFEAGLPVASSSSAPASTAAQPTGPPYQNPAAYPYAPPYAAGLPASVPPPSLPPAACVPPVPPGDSGLAVDDPAAVPGPLLPVKGDWTTHVALPLSHQVPPGGTYILPAGSGLPRGLAGGTELVKVTGKSCANCRSRKVKCDRRYPECSRCLKRKEHCDFGEEVSIALRPTWVIPDDESLPMSSQLRNPFIATSGINVRPSHIAAAPYPARNPMSHTPSSALRSLSYMQHQQALDRAQGHQPIVSRDAGGGGAGAAGAIVRSGAQGDETLDEADRSMTRLWENFLKASNLGHSSSDWRLALPTLATSLTLHLIDASMHSCCFHLPAFHVFSPEIDYFKSNVDHLDIASQVIVGILTSLGARASPHSAVLGIAGPDVENGEGSPEIVLSAGVRRENAWRAIVKRATDLCSSMEILQVPSARNAQTLVAFVQMLMLAEAKPKTARFFLRTAMGIFRDMQHSDLSAEEVQEIKISVGPTLFECDCRIAAYLGMPLLINDDDLYEYFDGTGVHVPDLAAEDLGPELDDILDPTYGRIDRPKLDRALGLTGYFVCAVQRAYAAIASSRRPSPRFRTAIPALWASIDRTHAAVQRLHRRLVQLDYIPEGCEHSHSVDYDLLISVRMDERLLDVVHLTHVWLGDLRKTDLSPQDRAALDELRAVSERRVRKCLKLLAFYSKVFNDSRDKHVVYHLFTQLEVLPNWVELAAQREGEPTEFGALPQECVLTETELEWFTTALELACFFTPLAANRLHELNAARKARQSGGAAPLPSVLAPYSVAPAGPSTFTFPAQPSQRLVPDTAPVSVATNLSAAFDSERYAPEHLLPSGQPLGSGSWSANPYQPVLSAPQTTLSSSSDAVHTAPQTYPPQPFLSTAPADFSASSSAEYTGSSDRSSISPRGQEHTLTDSTASSNDQEALYGALRDAAQEGTTEAVPWPAAYDGNSAPSLSANGGLDPALLTAAGIAATGPAGSTNASWTQLGETSQPATTQPLAWQAYDRAAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDI0</accession>
    <name>A0A2S5BDI0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDI0"/>
    <dbReference type="STRING" id="741276.A0A2S5BDI0"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF95">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="488"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="867"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="412"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="631"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="785"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="335"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="791"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1221" mass="133405" checksum="5BA16256A53397B6" modified="2018-07-18" version="1">MSGTTRLDELRRQSQAKLANFRPSEYSLRSWITTARVAFETAERHWKQGRTDNDVRKVEEAFLEYKRAAGILHIIMNHPGYQQMVSAKTPEYHSFVDLRRAATEAREPNDAVVRWLEQHEPAGTPRTNGTSSAASPPSTSRGLPPQLATRPAAIPAGPDENAVLPDDLARRKDGRPPSVRTIWCNVRVLRCERLSRGCLTTFLAETAAKSAASELLSQPAPIRHACIAVLEPAGPDDAVERSGSAPPILPYSQVQEPAKVWEESALQFRPEGGAPIEQREPGVSDRGPAGGVDVGPIRSRTSEDSAGGSRFADAFPSLDDFEKRIDPSDLGNLPSGRSRSSTTSSSLFQLPSVPTSDPSSASSNGGVAAPTKTARKPPPYPPKPQHLDEQAFRREQQERADKMAKLAAGLGNVDLSSSAPPGRNGLPSALVPGRRPSTSTQSTSPTRTTAPLPLPSAPQKNLKIPFAAEVRPLELWQYIQTSKAETGQGPRVLLLDVRGRDEYERGRVRGESVCIEPIILRNGIRSAEIEDALSLSPLQEATLFAARHRFDIVVIYDRASASLPTTAPTSTSPDAQRVLWNLLNAVYEREFSKHLARQPILLRGGWEAWEKQVGARGCVGTGVGDLVETERTAREEADRTEAKKANRRATVVSQPGESGRMLNGHTSMTPRPASPYQPSPVTASIMSPRLTMPPVAAQRDGPAPDYDPFSAGSTSPASLRRPSYPQPQLNGYGYGQAGPSASTSRASAYNSDLYNAGSSNMAAYVNGDAAARASSAEYARPAIDYPQLHSRPPPPPPVSDTTRPPPRTSSYDAVPNATALTRPPPARPAPPRLGSSFSSMQPAQYSAAHSNFPTSLLSFDEGVIGLSGLKNLGNTCYMNSTIQCLSAAVPFARYFTGGVYRKDINVVNPLGTKGALANAVAELIRMLWAQQYHFLSPVTFREAICRVAPQFRGSEQHDAQEFLGFLLDGLHEDCNYVVHKPPPIEMTPEREHDLETLPAQLMSEREWQIYKMRNDSFIVQCFQGQFRNQMRCLTCHKTSTTYNTFMPLSVPIPGGRGIGKVSLMACLETFVRDEILDRDDAWHCPQCKKDRKSVKKLSLSKLPPILVIHLKRFSFHGPFSDKLETQVQYPLTGLDLTAFVPPPLYDKRGQPIGGGPPNGYVYDLFGVTNHYGNLSSGHYTAFVRSGRDWFNIGDSKVTPCNPKVVESAKSAYILYYTLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDK6</accession>
    <name>A0A2S5BDK6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDK6"/>
    <dbReference type="STRING" id="741276.A0A2S5BDK6"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="801"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="956" mass="104590" checksum="5C95808B27FC9483" modified="2018-07-18" version="1">MHPLLGVGHSAAPPTAPNGGAALSGPSGEYRFAAPPPARIHSLSMSQSPGSSEVGEQNNSFRYPPAAEPASINGAANTAKKVRKSSQLADGGDDDNYLDEDGQPRKRSKQSLSCGECKRRKIKCDRKVPCSSCIKRGQPDACSWEDAKIEPEKQPFALSQDVDEIRERLRLVERFINALPPGLKGCFAELGITSMGERPKGDLKQADHDFEPVTLENVTESWQKPGCVKDEKPTDSLSVFDNMMFDHQAKYVTSTSAVDGSNKFDPEYTAWRTSIVAQPIAFVSPATAANHGLELCFNQDDFDRQVRQVYDRAYALLPDKEAIARATSTFFHRYEWFFAVLHRPTFMCEVERFLQMYETGRRYEVDPAWLSLLFSVIALGGDESAGGLDPGSPDADQELAEYGLPLHAAAIRFHVLSDPGGKAQIRTLQAVTLFACWTIMSAAGGLDFGRFASWLAQGIRTGHKLGLHLLSTDPEHMPPDDVALPPGKNSLKRETVLKLWGFMSFFDHLGGSGRYRSYLIHPSQNSTPPLSNVNWSDLSVDTWQLTPAPPSVVTDATLERHKHAMAGLARKSFDLLVASKQPFNYGMIHELDREYHELLDKMPDAFQHEYASLEAQDPYIRAKRYIAIQGIHNRIVRLHRPFLVKGWEPNSRFAYSSEACVRSAKIVLISHHNSLNLELGLSRNLRMLYSHSLTAATVLAADLFHAIDTDAPDVELQLKRDNFRLALDVFPEAVQRSVGSRMLRQIIAGARHVLTGLYNEQRQRRIRRKARLAAGQTSHPEPTFADLLHVLSSEIDGIAAPPASNEARSSFGSEASPSVATSSTTATLVDTPQLPHSDRPAAVPASAMLAGGPALSATGGSSAAKPISSNLMQDIGLINFNGHNWDFWTQPAGIGAGDAFNEAPTTATELPFANPVDTLSVAANDSDFSSWFGVGSTAEQVDQATQALLSQLASGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEM6</accession>
    <name>A0A2S5BEM6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEM6"/>
    <dbReference type="STRING" id="741276.A0A2S5BEM6"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="169" mass="18336" checksum="E9D02ECB55B09657" modified="2018-07-18" version="1">MSGLAILSIAVLGKQGNPLFLESYSARRGGQADLKWHYAAHTALDFFDERGASLAARWSRLACTDSPAYKTTDSYLGMLYAMEDYAVYGYQTNTRVKFVLAIALADAVIRDIDVRTIFRAIHNAYIGQLSNPFAALDTDKVGGFDAPITNKRFAAAMATIAGQSAQGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEV0</accession>
    <name>A0A2S5BEV0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Proline racemase</fullName>
            <ecNumber evidence="11">5.1.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.4" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEV0"/>
    <dbReference type="STRING" id="741276.A0A2S5BEV0"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018112">
        <property type="term" value="F:proline racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="10">
        <location>
            <begin position="427"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="529" mass="55434" checksum="447B2856E5F2BD1A" modified="2018-07-18" version="1">MSANKTLASIAAPAPQVEEQVVEPKQLQSAQQKLRFDKGLAETRVHRALMKIIKHSREAHTVNPAPPNTSNATVTFTPAVGQLFGLDAKNTLEVSNAFALPAGTFSGPPTEAKDESKGVKAAAKYTASLVNRLTDVNADASVVGFYTSTNNGQVLATGGFVEALVGAQLSGGGVGSGAKAQPVARPGMGAAKPATHLASGDANKSGKGIALVYDVASATQGAVALKAYRLSQNFVDAYRAGKFDTASLIENKLIHSGILEEVPVVVHSSALLTAFLSTLTAPTSTGPSSSLSTPSFSPLSLPTPSASAHIQSAAVPAPLTQPLQHLLSALETHQAHLSTLQFQSRQLARERTRLEAIHPNVAKRRQENEQRAKDGLPPLPLTDEEVRAGLKEPSRLETMCAVAAVEGAAKSLAEATGTGIVLGFAAGNASKGAGLFKTRCAQCHTVENGGANKVGPNLHGLFGRQSGSVESFSYTEANKKAAVHWDENTLFDYLENPKKYIPGTKMAFAGLKKEKDRNDLITWLKEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEW7</accession>
    <name>A0A2S5BEW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEW7"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="307" mass="33550" checksum="9C9B4C0E2C4D3B24" modified="2018-07-18" version="1">MASRSTLQRISAAVYLAEPAAVAASASTARKQAGNQLANGSPASAMRDPRMVLLCTWMGAQLKHAEKYVDAYRKLYPESTVLLVRSNPIDFFRRAAFLEAIRPAAELLRARSNGQIGPTSDVLVHTLSNGGCLTLQELNEHLRKNASAAGSAQPATIPARAFIYDSCPGLSTLTSTIRAFSAGLRNPLVYYPAVAGITVMYSVLRFWTIVRRQPSTLARISAYLNSPALPPVPRLYLYSDVDELIPPEDVERHAAEAKSKAGVEQVTMEMFAGSPHVAHARTDPARYWTAVKQVWEESDPQTDTEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFA3</accession>
    <name>A0A2S5BFA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFA3"/>
    <dbReference type="STRING" id="741276.A0A2S5BFA3"/>
    <dbReference type="OrthoDB" id="2525976at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="76"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="234"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="450" mass="48645" checksum="67FD8D72F1B73FC7" modified="2018-07-18" version="1">MAGLEQLLSLRDQLNAAIDQVASSPAAKALPALSDAGAPFPPLVAIDKNAALATAIAKKMTALLAGPAHVSEIALSGHFPACLRVAIEAHVSEAISEGETEPGAGLAVEEIAQASCVDPAKLARVLRLLAANYVFSEVRPGVFTNNRCSNGLSTGKSIHTLKENSQDVYAGTDGRAALLAHCTEDCLKASSFLADALLDPETSHSSKSKDAPITRAFKIDGTVFDYWAQPENKQYLTRFSHAMYAINQFMRGDESLTTGYPFRDMPRDAVLVDVGGGVGSVALHLLQHAPQLRFIVQDRPEVIGQQAPAVWKAKAAQALESGQVELQSHDFFRPQPVKEAAVYLLRFVIHDWADDEVVAILRPLAKGASSTSRLLLVEQSYRTLEPDPLVISPLPYLADLQMLVANNAQERTQEQYVALAERAGWKFVKAWVAAVGGTDSGWRHYEFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFE7</accession>
    <name>A0A2S5BFE7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFE7"/>
    <dbReference type="OrthoDB" id="2528407at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="181" mass="19761" checksum="DE87EDFC4B6EACF9" modified="2018-07-18" version="1">MRSAVLPILSPASTSGANNARVAHNVPIIVRRHFVELLTLSTLVAALVYFAIRKLHGKPRTGVGLAVERACGERHESLTPWLDALHGLEEKCPQLDADERAQIVANAKRQCGSWCLWDLDRNVKVGWHLSGDCFQPFSSPHECDQWWYQRPGLEGAVSSSDGSAPIQVDAGGSERLAEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFI4</accession>
    <name>A0A2S5BFI4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFI4"/>
    <dbReference type="STRING" id="741276.A0A2S5BFI4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="180" mass="19353" checksum="C3BA15F2F25D94F0" modified="2018-07-18" version="1">MVTQLDSGTDACTDDDIALKEVGSEAPLLGTGHTGVPLETPALLPKRLRRGKPTTRSPTAYIASAVVLFLLILASALHTGALRRYRWQTPPVDPTLNQKLDELSPAQNRVRNWLLEQRLETMGGIGVGLSATAPLDPRPPLASHAHPFEFAGEYEGPGVYINGSREKYESVAASSRSGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG20</accession>
    <name>A0A2S5BG20_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG20"/>
    <dbReference type="STRING" id="741276.A0A2S5BG20"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="81"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="256" mass="27382" checksum="8B30FF185B2AA7EE" modified="2018-07-18" version="1">MSLSLTRTNATSIVRLASAPVRSAAAAAAVRPATLSSTLPRIRPTPLSSPARTRPLNSTTVKMAPNDPYTAKAMSDASPSEKMEEMRKIIKEAKFGMLVTRSSDGQLHSRAMAPASHKGLVFQFIANTDSGKFDELEHDENVNVAFSDPSSTDWASVAGKAKVVKDEATIKDLWNPMIKSWFGDLKDGVRTGEPGDPRIGVIQVIPSEWVKTKTSLGQMVEVAKGAVTGETAAPGHLRVISASDLELARKTEGQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG59</accession>
    <name>A0A2S5BG59_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoacetate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG59"/>
    <dbReference type="OrthoDB" id="9970474at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518:SF1">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31014" checksum="C0106E2FB12337FF" modified="2018-07-18" version="1">MTAPGLPVAPAPWNLNGEGWMIPLYLPFSTTPIPLPPGAYAPLEAGTEADQSSRFHGGTGFVMLVRYRASDVGPYDELIYVPGLFKRPASDLPDGEYYPAITRIYVSTDASVYNGRRNWGIPKHRADFSFSHPQDQPHVTLVEVSLPVTDVEAPTRPIFRCALGDSSLMPFTMPISTSWLDIPFVNRILQGYQATLYQPPLPSHEDDPARTASSETFLVKPTANGRSRLAWLAPTSTQDDTDWTGYGNGVDFPRFEPYSLRLNFHLASFEMQFPIPHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGD2</accession>
    <name>A0A2S5BGD2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGD2"/>
    <dbReference type="OrthoDB" id="3366655at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="214" mass="22145" checksum="30B2446BA3F35A30" modified="2018-07-18" version="1">MADPDLYSQLRSTVFMSLSDLDYVNAAVSRSEQQLRPSENGASSSTRQSDPASREGDAADAESRPPSSSSPSSSPSSPSTTALSPTPGQSADFPEAVQQPSLASLLASLQTATLDAQSLGTSLSSPPNPPNDPTSAGEDDDDENEDEDLDLDSLKALLAKLDETEGAADDLEGRLDGLIDNLDALLGAMGGMALPDFPDSAKAAGETLETEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGD7</accession>
    <name>A0A2S5BGD7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_1089</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000010">
        <property type="protein sequence ID" value="POY75831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGD7"/>
    <dbReference type="STRING" id="741276.A0A2S5BGD7"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="871"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="901"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="938"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="63"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY75831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="998" mass="110792" checksum="F9C535299FF7BED9" modified="2018-07-18" version="1">MDEVLHPFYIFQIFSIALWSVDDYYYYAFAIAVISIVSIISTLLETRANVQRMREMSRFACPVRVLRDSEWRVEESTTLVPGDLIDLAYENLHTFPADVVLLSGDAIVNESMLTGESVPVSKIPIEPAVVRLVSAPGAEIKADLSKHVLYNGTKIIRIRKTPPTAGTKGGELEAVAMVLRTGFNTTKGALVRSMLFPKPFGFAFYRDSFRFIGVLGLVAVLGFCASSVNFVRLGIAWSTIVIRALDLITIVVPPALPATMAIGTSFAIQRLRKGDIFCISPTRVNIGGKINIVCFDKTGTLTEEGLDVLGVRSVVRSANVFAELHRDPDDVPIFGAADAKTPLLHALATCHALKVVNGEVIGDPLDLRMFEFTGWTLEEGKEGVGRKPKANADGSSKVPERAQTLVQTVVRPPGGESFKLEDALKAGKKHAHFLELGVLRTFDFVSSLRRMSVLVKKLKSTSVEVYVKGAPEVMVDICDKSTLPSDYDEILADYTRRGFRVIALAGKSMAGLTWIKAQRLKREAVESDLRFLGLVIFENKLKPGTAPAIATFRSAHIPTRMVTGDNVRTAISVGRECGMIPQLAKVYLPSFAKGGPSLPRSQIEWTDVDDESATLDPYSLKPAVEHDDRSVYSAYEREPQEYHLAVTGDVFRWMMDFGALETLQRMLVKGMIFARMSPDEKHELVERLQTLGYTVGFCGDGANDCGALKAADVGLSLSEAEASVAAPFTSRQPDIRCFLEVIKEGRASLVTSFSCFKFMALYSLIQFTTVSLLYSIASTLGDFQFLYIDLFLILPIAVTMGRTEPFPRIHPKRPTANLISKKVLTSLIGQIVITSAFQFAIFFFVRSQSWYRAPTIDPDELDIESFENTSLFLISSFQYILVAAVFCVGPPYRKPLYSNRWLILALTGLSAFSVYTLFMPTNSPVFSLLQFVDLPHEFHLELLLLIIANVVLSWVFEDVGAQRLAKWIGDMQRRYRRMRGRRKESGKAYKAIERAMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGI1</accession>
    <name>A0A2S5BGI1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGI1"/>
    <dbReference type="OrthoDB" id="2527245at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="540" mass="60857" checksum="DA36D41F9E8F8D26" modified="2018-07-18" version="1">MLNSSELPPMATAAHLVATEGRQTPPPPARTQHRRRVAGPSLYEIKTKHYLQCSNPITISSFTQLIAELNSAREDDHRTGNQLQRDDRLEWFRHEWLLGALSRVKPLEMLQDGESEVYSDGTTARDATGTRSTTPSTVRAALSEDENGERPAPREPLPEEARQQLLPPDAMSRGLVAERAIKHHLATRNQILRHSNFASLATVARRAIRQTLRTGRPVYVAPGLLDSVDWTQEYRDRGWAAPGIRWSVFRPDLIRFQQVKSGKEGGGTTVSWEVVEIKYSNKPRDFIYTSFKIQATFCEQALSMRDHLSLARILSNVPDLVPSHKLTFFLSRDALSPAYEERSVSLRTEQAFVEHHLFVLLPTWLEAVKESDWQRLQDALKESTRSDEACFLFRAADLVATSPDNSQSLRNRTHRLGPHSSKSCKRLSRYGDILPLTLRDSPPQSVDLTPRVWLKAAPPSPSRPRKRIPKNTPLPSLPSAGRDEPAQTSPSRRVPTPEVQLDPQTEDVRDLARLPALPDPTPDEADLLSDLFDRLLVEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGS2</accession>
    <name>A0A2S5BGS2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGS2"/>
    <dbReference type="STRING" id="741276.A0A2S5BGS2"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="437" mass="47084" checksum="4B9D04FED1983D15" modified="2018-07-18" version="1">MSTVRQSGERKPAVGADAQEGQRATVKPSLSASLVLLAPLTSPTADGFDYRVLLLKRHAKSRTYDSAHVMPGGNIDPIDQDSTAWSSFFPSPAQDVQQLATDSSRLTAPELQALKLCALRETFEESGLLLLEPAEPSLVSSVAKKLLPSSLTGGAPIASPQQTWAALPVAKKLYWREEVHRDGKRFVDLLRSLGADAKPALSLLTHWSNWVTPTVLPRRFDTHFFIAVLPPSASPLATEGTGSGTTHEALVSSDGVETTSADWLTPAEGVRRALAYSYALAHGSPATSATAASAAQETPIILHPPQFNLLAELGQSHRSLRSLLDSSRSEQPMSGQMLVRPRRVYPFTPQVAAVTDDLGRKRRATVLPGDEVYKYDNAEDEHLSGPGQRNRTYVLPPLKGQQGLVVEGCMRQGVSRTLGFGWEDMTAGDHGSSSPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH03</accession>
    <name>A0A2S5BH03_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH03"/>
    <dbReference type="STRING" id="741276.A0A2S5BH03"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="118"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="441"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="650"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="981"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="589"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1064"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1134"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1144" mass="123685" checksum="536FA6E0F688641E" modified="2018-07-18" version="1">MPAPKRCFDNDSSGGPSPAKRSRGDFDGSGRGRGGSSRGRGGGGSRGARGGPGGGGRGGGRGGRGGRSDARPERPPKEVFKPKAGFIAAGLKAYTDAAAGKPEGGDAPAGEPDISHHTTLYASNVPTSLTSPQLSLIFSSYAPVRAAFVVSTSGAGPKEAKPDFAGSSVNAISVKAGRDRTGKATSRGFGYIRFVLRSDADQCLNEWGSSKDGLPRSAVLELEGQEGLESVEWDKVCGPNGIKLQWAKKKLREGEEPEGGPKKVKKEKKPAAPVADEATEHGDDAGEAADEPQRKWRPGVWDHNAPRTVVVLGLPLPGEAGSTEEDGDENAGEDGEGDESKMDVENGDEEAAEPAAKGKPIDFKKALRQRARKIGDVEDVKFPYELPSGEQAGLVVMYTPRNAHDLMKKLNNHVFRGQLLSAAVKSSWDLCQRLGRGKGGGRLLVRNLGFDVTIPDLRAAFARFGSLHSITLPVDQNTSKPRGFAFVYFVTRSDAETALKKVNGTRIYAGMAAERIASEGGKEGKKKDVREKKKAEKASSGGGGGEKGRVVAVDWALGKEEWKKAQEGETGDAATASGDEASETSGSDSDSEEGDSDDDDDSEEDEDDSDTSPVPEDLEDRDTTPQPAPGAGNDGLDDEEEQEKKQDQGSTLFVRNISFEATEAELYDLFKQFGRVRYARIVYDPTTKRSRGTAFVCFWNEDDAESVLDASRALNEGSFGETSTKKTSLLMADPGSSAASPLTLHGRVLAAVPAVSKGDADKLREDRDKKGAAKTDRRNLYLMREGVIFPSWAIAKTLSAADMDARQSSFDARKALLRSNPSLYISRTRLSIRQIPLYVTDGMLKRLANHAIREFDREVKAGLQKPLTSDELVTFVPDASGAKEPTWNKVERKKGIPLGKVRQSKILRQNDRVDPVTGLGRSKGYGFLELGSHADALRFLRWANANKEVNRLFRSWWREELDKLVEQVEKGEGKVGKNVKATEKDDRLKRLLEKRKELEEEEKIAQEKEVARVVQGKSATGESGRSSRCLIIEFSIENAVTTRRRAEKADRAREKARRAKERDGDESEDGAASDAEAEDATPKKAAGKAKGKGKKRRADDEAESPGKKRSKKDAQAADEEKPVKAGVHVGTLIGRKRKLKMKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH19</accession>
    <name>A0A2S5BH19_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0799</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH19"/>
    <dbReference type="STRING" id="741276.A0A2S5BH19"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="331"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY76076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="546" mass="54731" checksum="FF2E6709FCED6F4F" modified="2018-07-18" version="1">MAAVESTTVASPHLDLISAVAFSPLGSHLATASLDHHVRVTHPSPNIPGAWDYHPRTWKAHDGAVLSLAWVDPEFGTAFASGGVDGVVKVWRQDTPPPKLGQTAAEANRSAPGKASSTAGPGWALAASLTDSRGTVRSISFAPSHFGLKVAAIASDSHLRIWDCLDPTGALREWTLVEDIDLGALGLAPSTGAGGGASSSYAGGSAVSGAAGYDVGSATGSSYGATGSATSGNAAFPSASSAASSANYGSSAAGSSVGYGGGNARAGGTVESDGGWAVSWCPEHWWGERLAVSSGPNGIVRLFHFPPSGPWHNYLNLIPSRLALSQGVSTHGHTTASSHAAASEDASQSAFSTASSAGSSSDPSGREQPASSTHTPPTSSLAFAPPSGRSYLLLAAGARDGRARVWRIVPPPLSLPSASSSTADHRQSGDGGGGDGEDGLELDGEWSARLEVELEPSLGERDGAQNGRGGATAASGGAGGGPIAVRSALGGAMSAVKVEWNILGTVLSTTGGEDGKVRLWKPTYTGQWRQIAVLSTQDAGANGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH89</accession>
    <name>A0A2S5BH89_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH89"/>
    <dbReference type="OrthoDB" id="10387004at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015615470" evidence="2">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="258" mass="28907" checksum="7EA28F6C9ABA4914" modified="2018-07-18" version="1">MLVSLAILVGTTLISAVQAIAARSAQTPLVPLFERADQRHFSLYDTGTSSGIGPVDLALPGSKIVRKELCYRNIYGRHERFEQLFEHQTPMQDAQGINFLLRDGFVHLVNGTETYVLEHCYPQDEPEALEDVNVCPVREGTSTSKWNRGISLHVDSGKRDWHVVFDQARFLDGFILPAERIPSDISSVGDELEGEEETDSDTASTIFEDEEEQDLDHEPFNPFADADFDFFAAFEQGYPGHDGCDEHGCWERKIVTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHB5</accession>
    <name>A0A2S5BHB5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHB5"/>
    <dbReference type="STRING" id="741276.A0A2S5BHB5"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="78" mass="8440" checksum="8C2D8E6710D91AF7" modified="2018-07-18" version="1">MATRAGLGIADIAHRVTVSGLAALSVYGMYGMWATHQATMKASDEAWKKHLAEEAEKTRLESDPLLKGFVDPPAERPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHL0</accession>
    <name>A0A2S5BHL0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHL0"/>
    <dbReference type="STRING" id="741276.A0A2S5BHL0"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="965" mass="105473" checksum="6125F131263BE33A" modified="2018-07-18" version="1">MPGRGAVQSAGPSSSTSLAPSYILRAHAAPVSSLTFSQDGRALISGDTDGYVAIWHLRTYRPRYLWKAHDGGILGLQEFDGGVLTQGRDNMIHLYCVPASVSADGTGQAPSIDVGAATAVPSPAAPSHGFDSPAWSMDINAMNFCRMHILPLGQRSVADVKGKGKAGPQDVFDGANMEALIAVDVFHYPSKARFHRSIGKDAFVGQKTGSVMAVHLLQLSDPPARVNTASAADPTRADERSSSTSTGEAEFAAKPATSLHALIAYEAGHLALFRFAPTSEFEEISLGHPGGQAGYHRPRDGKLVGENEGWDLVWAEKGHRDAVMSLAVDAKSRFAYTVAADHFLCKYRIADLSREEAELPRVHVEPTDSPGKSGVVVRDDGKLLATAGWDGQLRLYSAKTLAPLAVLSLHRLSLQAIAFAPLRPKDQSSLLDSDSDDSSETDADEKEIRQAEALLARDQPSTGDAAGKRWTHVAALQNWSRFLSQRSITRRLVLVAVVVTVIVVSLYGAAGSEDGSRQSSSGRTGTLSRLGDAPGRLILSYDEPRPSFKEQLKPGVRYIVANAYGGHGNQFIGIQKMLYFGKLTNRVGIIPTLIPAHLTGSPENISAFYDLDRFWQESHIPAVETSRLKAADLAFSEPLDEDISCWSVFEACVGSANMEVQAFTLHRIDLEYWPLPPIARALGNFDLSYDGLRVFDFDQAAKNEWIARVQREHLPQLPVEGEFQGDPATNIKPGFVPEFGERIAPDDQLMCFDMTLFLGPIMFPKLPVTAQPLEPNVPGEGLSWMNAGQYLRFNDHVESRADELLVDLFGVTKASKLPPFITIHLRRGDFKEFSGFTDLDKYVDALARVRARIQERLDHPNDWAGPGKHSFRSFGRKAKDYPVVCTTDERGDGDFIREVKNLGWKVVDHDAYDTVNRYGGWWPTILDGAILARGKSFVGTNRSTYSHLAGLRVKYWNGGLVEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHU3</accession>
    <name>A0A2S5BHU3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHU3"/>
    <dbReference type="STRING" id="741276.A0A2S5BHU3"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="425" mass="46876" checksum="7BBA3678A8DF14E9" modified="2018-07-18" version="1">MDSDSAAVLTIGATLRAGLVALLARSSSAHESVQFAQPSTTAFTLLKEGYHLLTRLRPQVNPYDSASCHTPPALLAFVGPLTQLGSEWPSYALWIGADVVTAWTLGRIASRRKRGKVLDTERERVWSPARVAAIHMLHPFAVVTMLARSTAAFSNLFLALALDAALGGSAIPAAFFLSFATHVSLYPAMLLPPLLLLAYSSVSPDQPRPDRRTFAVQGVLAFAAHQIALLAWSRWWTGSWSYLSSVYGVILTISDLKPNIGLAWYFFIEMFDHFRAFFLVVFALHPLIYVAPLTIAYRKEPLFACTLLVGTIALLKSYPSFADWAIWHALLGCFSEYLPYVSSPLFNTLLPLYAVLLLPAFHHLWLSAGTGNANFFYAATLVWAISMGGWAIEAVKAYGKRDVLLLQGEQGRAAWREGKWKLVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI21</accession>
    <name>A0A2S5BI21_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lanosterol 14-alpha-demethylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI21"/>
    <dbReference type="STRING" id="741276.A0A2S5BI21"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY76426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="59836" checksum="03D534DD5039A616" modified="2018-07-18" version="1">MGLLAYAGQAILAVFGSLIAAVVLNVAWQLIAPRDPTKPPLVFHYVPVLGCAVSYGMDPMGFLDDCRAKYGPVFTYPLLGRKITAALGPLGSNFVLNGKLAHVNAEEAYTHLTTPVFGTEVVYDVPNHVLMEQKKFVKFGLTTENFRRYVGLIRDEVREHMSKHVYANNTKTVSPGVDAFEASSEITICTASATLQGREIRAAMDKSFAQLYHDLDGGFTPLNFVFPNLPLPSYRRRDRAQLKMREFYISILEKRRASTDEPDQDMLTALQNQQYKTGEPLTDKQIAHIMIALLMAGQHTSAATGSWAILRLGENQDLQRRLYEEQVEHYLDKETGELRDLEYETLQTPLLNAFVKELLRVHPPLHSLMRKIISDCPVPATVGAPAAEPNAPSDFKKRTEGVEYVVPKGEYVLAAPGYSQLDEQIWGSDAKQFRTERWLEGGSKVPGEEDEGEEDYGWGKISKGGKSAYLPFGAGRHRCIGEQFAYVQLGVIIATLVRENSWTLDQPFPGNDYSTMIVMPAKPRKVTFTKRTGAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI44</accession>
    <name>A0A2S5BI44_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI44"/>
    <dbReference type="STRING" id="741276.A0A2S5BI44"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000007">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="498" mass="55597" checksum="A5AAC4CE68494D3E" modified="2018-07-18" version="1">MSSSSGEQTFVDWFKARGGTVHDAVGFKQFEGQGRGCVALQDIESELLSRPSVGSTRLARSLNEQQRSAESTTTARSEEVSERRRGADIRPRPQADTVLFSIPRPILLTTSTAALPTLLPAEEWAELGGWTPLILSMMYEYLRTSTWQPYFALLPTEFDSLMFWSDEELAQLEGSTVLGKIGREEANETFDETVKPFVEKHAAVFGDASDYSAELFHRMGSLVLSRSFHVDSKPDVDDEDDDEDSDDEEEEREDVADVAMVPFADILNAKSGANNARLFYEPTTLNMMSTTHIPAGAQIYNTYADPPNPDLLRRYGHVDEVNEADLVEIGLETVVDLVGEARGMGEEEREARAEWLLEMGIDDTFSIETNHKLPDELVSAIRAFSLSDEDFAKAQKKESPPKPKLDAESAAWARKIVEQRLGEYKTTVEEDEALLQDGSIPLRRRMAVIVRLGEKRLLQGAKSKLDAEWPEGEAKPATQDKKRSRDAKDGGRKKKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI80</accession>
    <name>A0A2S5BI80_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_0654</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BI80"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="646"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="1023"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1522"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="556"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1276"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1443"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1302"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1342"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1369"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1443"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1464"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY76453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1693" mass="183919" checksum="4D8538D6E743D711" modified="2018-07-18" version="1">MPSGRSRSDLSTVEEGSGGSQSPNERDAASLDCGANAPRDAAADAIQSSSVHSDKDTVHSRTFPFARSMSTSSGPPPPPPQASTSKQPAATDPATSGASLASQSRPSYIRLPPRHPALSDRQPFPSPDVTSPSGRFSVSSAESSGSRVTAPDLGGSSARYFPIRSVMYPSTSSAGSRGSRSGSTAMSTGSTGLPPESAEALLATEGFPSSPREQDEIDFAQQSFSVPVRDGEAVKMSREGGGSDHRNPRPGIRPVPDRRGSSSLTEGGGRSETSGYTSSFGTQSDTKPPSLDPFLSEPTTHAKIGDPDSDDEEMYGDDGSGEEGRAPRSDIQDHDFAGEAGNGRPRHTTQSSKEGRSRMLNPNEARYENAAREAGSTAGSNQPYVMTSRFEHQVTADGEHLILTGREGALERCEDEPIHAPGAIQAFGVLIAFDLRDDDSMIVQQVSENSGFVIGIQPRTLFDAKCFSELLSDDETDILLDALDALDARDADETNEEVGPYTFILSGEGAPGSGASDAHGRDRLKWSCHAAIHRPNPTQQPERVILELELIDDQVNPLTTKSDEPMSPEDRTGLGNPEDYGENGINPTEDEIIESTVSIIKPLRNLSKNKTSRASKRRAARRQRDDDFDVVGLLSQINDQLSKTDSLDVFLKIVAGIFRELTEFDRVMVYQFDENWNGRVVAEQVDWTRTKDLFRGLSFPASDIPAQARELYKINKVRVLYDRDQPTARLCCRSLEEVEHPLDMTHCHLRAMSPIHIKYLGNMGVRASTSISITAFGDLWGLVSMHGYGRFGHRVSFRVRQLCKLLGQSVSRNIERISYASRLQARKLINTATSEQNPSGYIVAKAEDLLDLFHADFGVLSIGEEAKILGAISNSQELLALLEYLRARNFRSLVSSQDIRHDFPDIDYPDGFQIVAGILVVPLSSSGTDFIVFCRKGQLQEIHWAGNPHANKTTSSTDQRPLEPRKSFKIWSETIIGKSRAWTDEEKETASVLCLVYGKFIAVWREKESALAASQLTNLLLQNASHEVRTPLNAIINYLELALDGPIQGEVRDNLVRSHAASKSLIHVINDLLDLTRTEKGNDLFLTDPFNIAETLEDAISMHRDEASRRGLSLDVVENPSGTPPTVLGDRAKIRQIVTNVVANALKHTDEGGIHIEWGEAIDENLDDALAAKKDGIRIGISISDTGHGITEQKLENIFRQLENVSTIGDRERDEHADEEKAVGLGLAVVARIVRNLDGQLQVESKVGKGSKFTFIFPFRLPPPEAAPSGEVIAADEETETERTSQVPEGGASLSRRMSTKSTGSNGSRASRASSEIDSLIQAISTNHMRDSPPASRPATASGRSIGSRSTGRSIGSRSTGSAQSSRSFRTAPTSHAVKSQRDDNGSVPGQVEIRNSATPLRASRVPDPSTSPLSSPRLGSASATGPSFNNPFFPAGFTARNGSANSATSGESLPADVRRRKSSLSQASTAPSGTDEMVTPRPSSPLHDTGISTREEGQASQPADPARSRQYAGEDSIEPMRVLVVEDEMVNRMIISQRLKKDGHEVVVAEHGGAAVRKFEEDRNFDVVLMDLQMPIMNGIDASKNIRRVEGEHPLPSEQRRPSAIINRGIPIFAVTASLPERDRQTIVDAQLNGWMLKPIDFKRLRTLLRGATDREVRHQELYRPGQWERGGWLADAPAPNEDAAGLVSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIJ6</accession>
    <name>A0A2S5BIJ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIJ6"/>
    <dbReference type="STRING" id="741276.A0A2S5BIJ6"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="8">
        <location>
            <begin position="237"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="662"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="469"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="696" mass="76692" checksum="777A04C09E0ED1FA" modified="2018-07-18" version="1">MASHDAAASNLSRTSPLGGQPDATRGRGSDDDRLPRAMTSLSLGGGAQGTAGSPTTTPQQPPQQSQPPAKDGGAAISRTSSFSRAASFRFTPRDSTTPTAAEVSSPPLSTSPGVGPIASPYPPSAASIATLPTSPDFGPISPGGQAIPKALHRSTSLSGQRPSSSSRQHSTTVSPITSPRDEQRGTWPYSTANSSTSSLVSTTTMGGTVHHRDRSTELEGKEVSFGMSAGATIEKPDYSEAKIVVAMVGLPARGKSYLSNKLQRYLLWLEYQVKVFNVGQYRRQVYRKMAEESGRKEDQSANFFDNNNASAAKARERMASDCLEDLIKWLKAGGNVGIHDATNSTRARRKALEARIKREPGLKLLFIESVCTDPAVIAANVAVKVASGDPDYDGQDPLQAEKDFRERIKHYEESYQPLDPELDKGQTWCQMVNVGKQVTVNRIDGYLQSRIAFYLMNLHLAPRSIYFTRHGESQYNVEGKIGGDAPLSKQGEMYMRALPKLIKEKIGDKPLTVWTSTLQRTIQTASELPYEKLTWKSLDELDAGVCDGMTYEEIEKYYPEDYNARDDDKFNYRYRGGESYRDVVIRLEPVILELERQKDIVVVCHQAVLRCLYAYFHNLSQEELPYIKIPLHTVIKLTPKAYGCDEERFALPIEAVDTTRPRPTNKHLAIKKERDLGMLSPSTSRPPSRGKGLYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIK2</accession>
    <name>A0A2S5BIK2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate/glutamate/uridylate kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIK2"/>
    <dbReference type="STRING" id="741276.A0A2S5BIK2"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000018">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="554" mass="58748" checksum="7B3A4066B7A86FB0" modified="2018-07-18" version="1">MVNPLTVVIKLGSSSILHPEPPHFPQIATLSALAETCVSLRALGHRVVIVSSGAVGMGLHRMELPALAGGKKRAIGEKQALAAIGQGRLIALWDQIFGALKQPIAQILMTRNDIADRSRYLNATTTLSTLLSLGVIPIINENDTISVSEILHINKFGDNDTLSAIAAGMCGADYLFLMTDVDGLYEDNPRRVPGARRVTKVRDIEEVRRLVSTSTLGSSLGTGGMETKLIAAELATAAGCATVITLGSMPTRILTIVQNHAARTVPSSPMLGSSASLPQQDSSTTSREPREPSPSALPGVEFAATPASQTTIDESHPPYTLFTPKVAPLTSRRFWILHGLTPRGTVFVDEGAYRALTRGERDGGGSGNGGRLLAAGVLRVEGAFAAGQAVRVCVLRKKGTTTRRGQGAERSRGRMDARSVLSSTPGTPGTPGTPNQDDRPHMLSRASSPDHFADRRRSVNGSSAGGSSEQLLVEDIEAMRIGDGSPAPPDSMEPANEEDEIIEFGRGLSNYNSVEIDRVKGHRSSDIEKIIGYVEAEHVVESIVELRAATGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIV7</accession>
    <name>A0A2S5BIV7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRF2-interacting telomeric protein/Rap1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIV7"/>
    <dbReference type="STRING" id="741276.A0A2S5BIV7"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRF2-interacting telomeric protein/Rap1 C-terminal" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="867"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1164" mass="127544" checksum="9C141454289BEF06" modified="2018-07-18" version="1">MPADLVPPARKAFTDKDRQRLAQYLVNFPSADRTKKRIFDQAGAKASVPSLPGHTAQSWHEHYRKTGREDVDRKIQKILRDRERQRQSRRQDAAAATAAARESTSSDVDQLDDSEPERQHQPVASTSKAPFAAAPPPPPATASAKQRASGPGSGSKRTLCMHTEDSSGDDSAAARRWESGKARAERKTRAAFTDDDFDLCVKVMVQQAKQGFTNRERDIALAEKCPDHTVYSWQTWISNNRHELDEAVRDYRKHRAARKLAKKDKHGRGEQQEQEEEGLVDSRNGRVSVKAAVSSEKQREEKGASRQRQDLTRPPRPDPAVDASIARRADHAQQQQRLRNQTVALRKKEAQENAIRRQHVAARSFDDDDFDDDYRPGHRRLDKGKGRAVSPQESSPDAPGWTIPRVQEESQEEMDGLLAVASGDAVDRFSDFTDEDKHELVHQYARNLVKKHDPDTCFVYLGLKRPQHTEQRWRAYFHYKLAEILGLVARKVQQIEESQAAKAKRLSAAAASAEQEAAKSSSAAVAAMRREEERRRAEIEADERVARENEERFRREEERQDRERAERARAASLATRAGQAQRQPATAGDVFAARSARPAAPGEVVVDSDGFDAASPSPEPSHLDPAEVNDRVLVEATPDKSSEAAATQSGLVRTPRHTPPTRGSQEEQEENLPRSAASQAEALARERESDDEGSSPGSAEPRHSQYSVMPSPFIQNQNGSPADVDVDMVVDDATVKDETDDDRDLIITPAVEPSRVRLDEADALDDDDDDGTFWNALSPAENAHINGLHALVAVVQQQKQQQETARAAGSSTARARAMAASKATERLDDGPARADTGMELDNAPSPVPPSAKGVLLAAEHDEQPQHEAAAATVPAEAPEPLAGNPIASPSRKRRREASSPPIQYMHELKEDEAPAAKRQKMDEPAVALAPEPASTNQAAEPARQGRKSAPSALPARAIGTPTPTPGRRISRASLAVMSTQATGSPARERAAPAAPPATAASKGPEAVSSARPPQASTGPQPAATAGAAPPKSTAAAKAPRSRSLADEIGDLARQYGVHRETIKHIMFCICAKGDMVNLAHLVKWFSPTHRPAEGTPEHDELRQLAHDQVWTLREDTIVLEGSDSALEQLARKRGLPAIKKRRHFLQRAKITSVGLLRKDLYMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIV9</accession>
    <name>A0A2S5BIV9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIV9"/>
    <dbReference type="OrthoDB" id="2528625at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="57587" checksum="8DD9DA2389B9D072" modified="2018-07-18" version="1">MESAAAIPGALATLAGAISALPAPVLTINASLLTSMLETVAKDLAPTLPTLAQAQQEALLTNATFLAGQFEALVGQLARSRPMLEQATHDEAIAMIQISATRYDILTVWGPEAWAILAFFVIAAALKTALVVMLRKRTIDRAVAASMPTASSTIKPTAMDREVARARLQKPARAALGHALNLVVSTICIVLQLIAWRLFVLPSMPLRVLDLQLITAAIKLLLVGYAADLLFGDLRPEIFLHHFFTFALLFVGQLSAFKCQDPRFFRLAQYLLLQGTLEQTTYASMVAWHAASWLRVQDRRPGLQRRLMLIASRLMYVSKITTFPQKFAPAGFAIYWLAEMWRNIDGSAWGRAWIVWCTMLLVMLLILQVKFADDTFPLADHMSHKVHGGPPPHRLGPVFRVFARIRGKSSGRPRRPTHSASQTSAEDRRSRSTSMTWLDKNIEEGRAFEGPVESEKDTEEPVSPTTVPLTHSDRNSLTHEGTPTRELVELPALAYGVHDPSVTLDNTRECSSQDQRTIDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ67</accession>
    <name>A0A2S5BJ67_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ67"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="186" mass="18978" checksum="F78BEFD4227BB936" modified="2018-07-18" version="1">MSTSALTTAPASPPAPPLPLSSDPPPPPLSPLDSPAVLAAQGLENPMNDQKQDSATDTVPHNGVLVPAAGDGGGSGGLVEGVEAATEAHEDERPQSPKTTKRTRPRIITIVKAARPPDELPDLRARGLVPISLMRAVLVAPAWVPSAATPTASAVSAAATPTSVRPVFALAGVNNPSRTLVQARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZH0</accession>
    <name>A0A2S5AZH0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_7070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZH0"/>
    <dbReference type="STRING" id="741276.A0A2S5AZH0"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY69938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="209" mass="23013" checksum="F5FBA5CAFA97F218" modified="2018-07-18" version="1">MSSGLEKSLFQLKFTTKQLQKQSRKAAKDETAEKAKLKKALQQGNQEGARIYASNAIRKKSESLNLLRLSSRIDAVASRVETAVTMRTVTGSMASVVKNMDRAMQDMNLERISAVMDKFESQFEDMDVQTGYLEGTLSNDTAISAPSDQIDLLMSQVADEAGLEVAHELQGKSTDKVPTLVEEPTRTAVTEEQEDALAQRLRALRPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZL5</accession>
    <name>A0A2S5AZL5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_7024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZL5"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="142"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY69980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="542" mass="57412" checksum="0386048F6E048452" modified="2018-07-18" version="1">MPSPYTTPIRHDDDECYPNRPQTPGDEIESEAPTRVNSPSPSSPTSTVNLSLSGSTPAPSRPLSFIDSLESLEGPTRVGSPEGSIYEGKEKNKVFLDDVAAAVVLGKGADLEKGTSTLSEKQYEDTADAPVTEDEFPEGGLRAWLALVGSTSVLLSTFGFSNSFGSLLQYYKVHQLRDYAPSDISWIGSLHLFLTFASALYSGILFDAGWFRYQLAIGSIGWLLGIFALSFATTFWQILLAQSVTMGLSLGLMFSPCLSILGTYFRRKRGLVVGIAASGTAVGAVLFPVLLGQLFEKKGFATAIRAAGFLMLALLIVANLTIRQRVVPKKAQSATVEKPSTSTILRRIVKDPAAWIVMLGVFGVYVGCFIPLFYVVSYAKQYSSNAALATYSLSIINALAFFSRIGSGMVADRLGVFNTAIPLAGAVAVLSYGMIGATSTAGLAVFLVLFGIAQGGWISVSAALFMSLTNDVSELGLRSGIGFLFVALATLIGSPIAGALLVATDGSYVAALCFGGSMALLGSLCLVIGRGYQVRRKSSQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZN0</accession>
    <name>A0A2S5AZN0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_7028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZN0"/>
    <dbReference type="STRING" id="741276.A0A2S5AZN0"/>
    <dbReference type="OrthoDB" id="2218151at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY69984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="37291" checksum="C104504E7DFDDBCC" modified="2018-07-18" version="1">MGLLDTIKSRLPTRSKVPIPFSPAGIEGKTNGEVLAGERAGYGGVPTSEGRAPPALGKLSSRQFEADSTVPKIVRGFEVFFPFVNLCILVGQASFQRRWGVGISARVVVSLLSCLQGLLYSGFVLASFLLADTLRFLRGPERFFKQIRSSIVLDSSQVALNLLLAIVTTASASSAGCKDPSKDPHADKEGYTDALPSFCRNKRASAAFFWLAFFACSATLAFCLVTFARVRRAPTSSAFVPPTGVAAPGGHFPQDADDATWTGRPSYDAVPARGSGSATAPAGYRPGHAFSNDGERLFAGHAPGYGVRDPFEDPEQSDGDGRGNVAYQAIPDPYEAIRQSMERPAQQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B083</accession>
    <name>A0A2S5B083_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B083"/>
    <dbReference type="STRING" id="741276.A0A2S5B083"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35107" checksum="D4C16D4DE260BDEC" modified="2018-07-18" version="1">MVAPAAFDPAVHLSYVKPSKVITMKDLALDGGISPIAVTEPFPLFSPDGVAQLRRDILSPEVLDKFTVTSYLSPCQAREFTPAAAPFVHAAWRSPEVIAAVSEAAGIDLVPVMDLELGHVNYQLGQKGKDGLRETPVVPPVQTGHFTGAELERVKALAEADTGEGPDNNVCFHQDAYPFVCVLMLSDCSAMVGGETALKTGDGRIVKARGPGVGHCVVMQGREINHAALKAYNVDERITMVTSFRAKDPMLRDASVLKTIYPITKRNRLNYQWSVYRMKLLAARFSIMARELEEKKRASGDDDKDGLGGSEIVEVETMSDFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B092</accession>
    <name>A0A2S5B092_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B092"/>
    <dbReference type="STRING" id="741276.A0A2S5B092"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="398" mass="41589" checksum="FBF2CC523EE32DF6" modified="2018-07-18" version="1">MSAVKTGAPEAQELERDDCADYAAAPLEDDIFSWHFTVRGPKSTDFEGGVYHGRLVLPSEYPFKPPEVYMLTPSGRFEVNKKICLSISSFHPETWQPSWGIRTALVALMAFFDSEAKGAVGSLDAPPAERQRMARTSRYHQCATCGFDAAKPESFAALPAPTVTSSAVEAVKDDEATAVQESVAEVTAPVAVTEPVVAQRKTPPASIETTIFPTSTATVRTPSSARHATPREPQAPLDPHSHNPFSSPLASPSTSSFRHRVSSAQTASPSLDSVPASYVPPGAPRLSPAHLPARNPFSASAAAALPNPLRTPDLAVGDNQPLHTAPSPTGAVAPAAPAAATTERNGVEPDAIQLPALPPGVSLAQVSSGGVGGPPSWVDRAIVACLLALVALVVRKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0G7</accession>
    <name>A0A2S5B0G7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Arsenical-resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6717</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000136">
        <property type="protein sequence ID" value="POY70278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0G7"/>
    <dbReference type="STRING" id="741276.A0A2S5B0G7"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47837" checksum="78859D9001FB201E" modified="2018-07-18" version="1">MSSVNRPAPDEIQPMGEAPKATEPVSPLPSQEARDDDASQVGHADVVTGKPALKRLAWLDKLLAVWIILAMAVGIILGEFVPQTSVVLEKVKFVDVSLPLAIALIVMMWPILCRVSPLALVPLFRRRQLWQHLAFSIFVNWIVSPFLMLGLAWAFLPDKPELREGLIVVGVARCIAMVLVWTDIADGDVDYCAVLVAFNSVLQIVLFSPVALLFINVFKAGGSGASSVSISYSLVSKSVAAFLGIPFAAALATRAFFVVIRAQHFFEHRFLPAIAPLSLIALLFTILIIFAGQGHQVVDSIVDVVRVGAPLIVYFIVMFFSILYLCRYLRVSYRRSTTQAFTAASNNFELSTAVAVAVWGAKSPQALATTVGPLIEVPVLLGLAYLLVFIRRRTRWDIEVDAESEEDRRVDRDPEVAFLDERKESTASSATRSDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0H0</accession>
    <name>A0A2S5B0H0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0H0"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="3">
        <location>
            <begin position="81"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="311" mass="34831" checksum="C459D05D0E392663" modified="2018-07-18" version="1">MSSPKEDDGFTFVTHKKQQASRPGRNRKGKNRFRERTLDEKLQAREAELRRSGYLEQCRKMLRDALSPASASETADTVQEPYPPPTCVVCLGLGSVSDSTKAQDQYVMLKELLFELQEELDPGIKAAFYDPVFSPEDVTFLEEQGHVVRPANHPLRLDQPTLLYIPHGPRTLFEAILAANWDSPEQLSRVILFGNRLDLYDDPTYSGSLRDRRKDVDGTGDELGESAELIAQAAKLFRILPLPSTKEHLEAFNDLALQHVTPRKSAEKPATFWRRAPPDIDEPCNSATSPSSSQVEVVEAATDAIEKLSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0M3</accession>
    <name>A0A2S5B0M3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="7">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0M3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0M3"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="656" mass="73273" checksum="E4FD4D132489CF9F" modified="2018-07-18" version="1">MLHRAAARTRSRASEVQSWLRPSVNAYSSPARQRPPVPDFERHPAFKQLDRDLDEGRVPCFPANGDNVRVLTEPSEFYQTLLVSAVVVSFSARRTSSPRADDSRPGDTVQDKIRKAKKRIFIASLYIGKEEQELVRPTLPGRCHTGSDLLTPSRPTHSQVQTLHEALRANPDLQVSVLVDYLRSTRELPGASSASLLASLSAAFPHQVDIRLFHTPALNGWQKRWVPKRFNEGWGLQHMKCYGFDDDVIMSGANLSHDYFTNRTDRYIEFRSHPPLADFFHSLLALTGSYSFRATAQDTSTLYPAVKLCWPEGGADGVPANRIPQNPFDAPPASAIPAFREHAHNSISSFIDSWYRKDQFALAAALPVPSVARTSRSPRPPPSPRSRNSALLASFDTRLRPVVQMGPFDLTTETDLVVPRIFSTANSLATAPGGNRTVLDWTSGYFGLREDYKKLALQCKAKVRIVSAAPEANGFFGSRGVSRFIPPAYTYFAEQFYREIEREAERKSKRTDGGSADGLIEMREWRRKGWTYHAKGIWLAPSVFNPLSPPAPTSTSTTLTVDPHVDEFSLRYSHPSPPFLTLIGSSNFGSRSASRDLEAGVLLTTQNSALRWALENEVRLIRKNADVLVDRNLFEKSDRKVPWGVRKAANAIETML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0M5</accession>
    <name>A0A2S5B0M5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0M5"/>
    <dbReference type="STRING" id="741276.A0A2S5B0M5"/>
    <dbReference type="OrthoDB" id="2529479at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="879"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="904" mass="96189" checksum="F38C113BDFCF7A7F" modified="2018-07-18" version="1">MDEADATSDKFIIFKEVGGETVLKQFARSQGTLILGRASKSDSAAKDPCAPKFRNEKTRVMSNKHAELSWEDGVPMIKDLGSTNGVRIKRENDWHDCAPLVAYRIKQGDEIVFGKPIQDPDAVAEVMCEPLIVAVSLSDTPLLSIDGPTGLESNLTALLLKRIRTMGDGRSDSQQQQREDITPEYEEPTATLWHAVDIGESQVSSLGSPSPVRVRDQTDESSPAKRGFGMTDVDAYMSHDEIASEAEAEAGREEPVDAEQPANEAAGLEPQDVDTKEDVAYKVMEDGKLSAPLPGDAVDSDLPDGKVDAGQEAKPTKDFGTAELDGTGNVLPIAQPPSPSLTADERRETDDTRFAPSAREVILGRSIEDRSRFANAVLVSSVGVTYSDAKSLEVESPGTASDLPSPASSVRSLDQLEGERARENPTEDEFKSSDSTSKHLEPSQSEPRLEGLFTPDEDENYLEWLAQLERASRGELQRTAPCRLNTTSPEPPNPVRAVTASEAAETGYDGPLADQPEEIEVVRAPEDYVFWVPRPGALVQAGPEWHKPLFFNEPLGGLPLCANDALRRDTRSGDLAVAMDDAGSSQIGHHLVAPAKQQDDARVEVADDQTGQAAQADEIVGVSLGADHAAGGIEGECGDSQGRDHHQMEGVEATENSRDRSGSVEATDHAVKDEGFVDEIGSASADALDAHHSGVLETDATEHVQQASDVDTQHHAEGDAKPNDLGSSTSDVLGTDDGTDSEGVEDAVGSEASAAAFESEADAEEADDSLEKANSTASSQQSDGESEFSQDDEVSDGEASGSEVETSDASDASDASQSGTPSSPRSSRKRRLDDIYDASEDDDEFANSVEDLSAVKGGIAARASTPPKRRRFDLPIKSFSLGLVTGVIGAIIGLSALDSLLTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0R9</accession>
    <name>A0A2S5B0R9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0R9"/>
    <dbReference type="STRING" id="741276.A0A2S5B0R9"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="100"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="466" mass="50715" checksum="8E28034E3BB79E5B" modified="2018-07-18" version="1">MASQSTTDQLLEVFGFLTDPQAPVRRIALASLLPYTAADAPERKLFLRDSHIEQLATMCADVELIAHDALSALINLSNQLEVVQRLDKYPGYLAGLVRMIIDDKAVLSDLACMLLSNMTKLDSAARDLVALHVPFRFVDADSTAASAPGDADEAAPPEPKKQKVETSEFELPALDLLLEVFLKGDDKKYNPNATYDFLASVFANVSLLPAGRAFLLSTPDRKAEPPLAKIISFTEHPSTIRRGGVASTIKNAAFEKAGHTRLIAPTNDPVADNGCIDLLVQLLLPLCGSEEFDIDILDELPQDLQLLPPDKQREPDAQIRGILIETLVLLATTRANREAMRARGVYHIIKEAHLKEQTPAVKEAMVRLVNLLMRDEGADTAVEEVDVPTDASELPEVPAFGQSGFVSASGEQVAKETAVEEEDPAVEDEPSASAPVTEAEPVSHHDNLPLSKLQPEEDEDEMLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B132</accession>
    <name>A0A2S5B132_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B132"/>
    <dbReference type="STRING" id="741276.A0A2S5B132"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="862"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="887"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="3">
        <location>
            <begin position="85"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="536"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="919" mass="103176" checksum="DC2159C39C59E99F" modified="2018-07-18" version="1">MAAAVAMSRSASMASEITSPSVSFRDVASPLTVSRRASQISFAPSSRPSSFAGRSGRVRSIRSISEVAELSADLIALAQTHRRQYLMAEHIFRRCEAAGWFPDANWGNIVAVRASVGTAGTSTYASYPLAHEVDGADVLLDGLATINAEAAVIVSSHVVRSILQMIDDNTERVVLNEDVAIQVIDSLEDLRGAKRHQYAAFVRENLALVLWSDDVATLIPHAQTLSDLMLSYIWREQDDTETEEEKDIDQVPQVAVLTGEADPEAAEIAGYKRRPVGLLSPLHVGLAVGINILVQLLTLETIIREFLEDGYWPRFFIALAIPFQFCVSQFFCVVVIAIILQLLGPVKQMHQNNRYYSGERPPRMRGPLPSVTVLMPVYKEGLDTVLLPTIRSLQDAIKTYELQGGSVNIMVCDDGMQLLNEKDYLVRKAFYEANAIGYVARPGHGKYYKRAGRFKKSSNLNVALELSIRVEEMLKERRPERSVDNPWTYEEDQVLYEKCLQDALEEKKRVFPAEKDDEKPKIVGPWASGHIRMGELILIIDSDTRVPVDCFLDAASEMHHSPECSIIQHVSDVMIVEGNFFENGIAFFTRLVNTSISWVCSNGDVGCFVGHNAFIRWSALQEIAQWKEDEKRWQIWSESHVSEDFDCAMRMLVAGYDVRWATYSNGGFQEGVSLSADDEINRWQKYAFGVSELLLHRLKDWPFKGPLTPMAKDFFWKSNLPLHYKLSSFSYMMSYYGISVAFPLSVAGYILYGMFIPSLDNAYMPSWKVTVALMLVFGCASAFAFAVLRYRSGQCGLHTALLEQAKWTPFNTLFFAGLSLHVLTALLAHPVGYDMTWAATVKESTNRTIFTEVPAIMKRFRLCFIVCSMCIAMIVVFAFLPLMEWQIIDWVSIVPLALVVGGHILYPFLLNPAIMSLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B161</accession>
    <name>A0A2S5B161_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6433</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B161"/>
    <dbReference type="STRING" id="741276.A0A2S5B161"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000836">
        <property type="entry name" value="ABC transporter B family member 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="169"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="538"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="802" mass="84805" checksum="DA25408788E0E3D1" modified="2018-07-18" version="1">MASTSAAGLVPPRLVLASIRRPAVVAHWLPRPDTRSNRAFSAWQSSPPRPGTLLAGTASSRPAAIAPLVAAGSRVLATTGARPPSALACLAPRIRQAARWRSTSTAVSNANGEKGKEVARPSSTTAVEEVTPSPGEEVEQVKTSLKEKVQMSEVRRLLHLARPERKTIAIAISLLFVSSLVSLSIPLCIGRIIDIFSGQANSLPISVPTAAVLLATFFFLGAVASVARLILMRISGQRIIARLRQQAYTNVLRQDIGWHDLQGASTKAITTEGTAVRTARSGTAANGAAESSSGSPRVKETGVRSTGDVISRLGSDAGIVGDSLTRDLSDGLRSLVTAVVGIGAMFYISSKVTSVMLLIVPPISVAAVFYGRYLKKLSRETQKAVGEMVAVSEERLGAIKTIQALNAVEPTETNRFAGKVDKVLDLAKKEAWASGLFFGGTGFAGNMTLIALLTYGGSLVAHGELTVGNLISLLTYTVYIGGSLVSLTSFFGYAHVFNTIMKGLGASSRIFELLDARPLTVQLGVGRPLPITTPPRRIIFDDVHFAYPSRPGSEVLRGVNLSIEPGTIISIAGGSGSGKSTIANLLERYYDPTQGRVLYGDDNIAEYTPESWRQRIAIVPQDPALFSATIAENIAYGRPDATRAEIEEVARLANCGFIQTLPRGFETQVGARGAQLSGGQRQRLAIARALLQKPKILVCDEATSALDAASESLVNEAISNISQTQQLTTILIAHRLSTLKTADQVVFMEDGVVAEQGTYDELAREGTRFNLLVRSQLLGGPAPATTGTSASLQPGARNAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B164</accession>
    <name>A0A2S5B164_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Medium-chain acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="10">1.3.8.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B164"/>
    <dbReference type="STRING" id="741276.A0A2S5B164"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="44"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="159"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="267"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="421" mass="45362" checksum="3844C0882BAC7B2C" modified="2018-07-18" version="1">MFSRLSTRAPYALKAAPRARRAFATTRANASSGPDESGPSFLLTEEQVAFRELTRNFTANEVIPVAAKYDRSMEYPWEVIKKAHAEGLVNVHIPEEYGGAGLSVMSSSIVSEELAYGCSGIQTAIEANGLASAPVILAGNDDQKRKYLGRLTEEPLMCAYGVSEPGAGSDVASIKTRATKEGDKYVLNGSKCWITNGSVANWYFVLAKTDPEGKPSRALSGFIVDADTPGITVESKLINMGQRCSDTRIINFDNVVVPKENLLGKEGDGFKIAMGAFDITRPLVASGAVGLAQRALAEAAKYAHDRKTFGVPIINHQAIGTMLADMAIGVECSRNAVWRASLAKDHNDPRTTYLASIAKAYASQTAVSNADKCVQIFGGAGYNTEYPAEKLYRDAKIYTLYEGTTQIQNLIISRVVAQDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B178</accession>
    <name>A0A2S5B178_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B178"/>
    <dbReference type="STRING" id="741276.A0A2S5B178"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042859">
        <property type="entry name" value="NOL11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633:SF2">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1114" mass="117953" checksum="04CEB27D01E1E787" modified="2018-07-18" version="1">MSLVGGQIDDFVVASFPAPAVTGATTATAASRTTATCVNYTSNAKTDHRVAIASPRVGLAVYDLDDQTPLASISVGPSFAPCTAPASRSTPVTQTASESTRVKSLRKTWVGVRSTLQQQANDDATARAGEIWCFHEDENKDGSTGSADAPKAVWPISEPLASIVAPRTLPEHIVFLSETGTLALAPQDDLTKLSSLAAPPLPSGANALSSQTLRVVPLTSTTSSDFVPSSLLAALPPAPAQPHLAFIVRTYAAAATAAPSTAEASLTGAGKKKHKKQARPSAAAVIDAAESVGPSAASTEPTQTSRICQVELVLLDAAISVPDEFEPRQGLLRLGRVEVPGASEVVVSDEGFVTALDASGVLSSHRLGFAESLAFEAYHALFFPAASSDNADDTAAILPLALNFVKSIPLSPTAVSPARSALLALHSSFVALASPRPRSPASDSTSQPPSVSVTYWDTRFGSVIASTELAVPSAVAASVDGFAVSLSRVGRRTAIVVIEPAATSATIDDKSAAKRTVLFGLPLNGLPSASVLAAVVGKHTLTAKYVASPSTSASAGGSNATASTSTSAGSSGAAILEQARRAEPMRSELLRTGNEKKAALLEQSRIAREQLLESLVDALEPLRVGASTKEQDKAVRSAESSWDTYIEEERDRLWEYNKDKVRLAMEKEKERRVAAIAGLTRSGDAGAAEPEEGEASRYKVAKRRIERAIAAAGASIRPGTEAAAGSGKSWKDVTAARIKGVNDKYRYRYHTERNKIEAEMGQTVKEFDWEEAVDKVERFEPSLPSSFVTALLRLSFPVPLADASTSLEIAAPASNAPKAKATVYRHPTKLVGYLLGRELVGENQVEGGVTRFLARAGDWPNILQALRTVSDISESTLVSLLVAVVRDSSSAHDDADMDVDSDVTALPCSAPRLPTFLAAFLQAPYTGPTLRSALQKQLSPSDAVPVLEQCDAWLKRWLNEAEPVRTKDEDEKRKRKGKGHQTVAIDVFKVAVRDEDVPALDQVVPFVQAVLDAHFVTLLLQRQSHRLLRRLSQHVARHTEMSTDLGSLLGALSIYSTKKEEQRRAALAAAEAKAAGTGATTTGVKELGATMEKRIAAQEKHAEVGQYQVEEFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1B3</accession>
    <name>A0A2S5B1B3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000114">
        <property type="protein sequence ID" value="POY70584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1B3"/>
    <dbReference type="OrthoDB" id="2532064at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="246" mass="27166" checksum="F78D682B967E901A" modified="2018-07-18" version="1" fragment="single">TQTDPARKRKKAQHGQGKKTLARLRANERAANRAATNPRSRDKQVKYHNDRTDSIAHNTCLENGTFGVLFMAHPLHLGRKKSAGFCKLIMSDEFVSTDPTVPTDGIDLAPILSDSRARADLAPLISPDALVRAMESIFTAHVHLLQQRAAGVNIGKVHSSDELVRAANAKAEEADKARRTVEARLKRVEAELERRKRRRLRRGEESDEDDDKEGSDEFDFGDLLQDSDAGSAGEGLGERVGDAMIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1J4</accession>
    <name>A0A2S5B1J4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Palmitoyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_6332</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="12"/>
    <dbReference type="EMBL" id="PJQD01000110">
        <property type="protein sequence ID" value="POY70659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1J4"/>
    <dbReference type="STRING" id="741276.A0A2S5B1J4"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="468"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY70659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="797" mass="85530" checksum="8DAF7C230F8F4580" modified="2018-07-18" version="1">MTELSSSLQQTKGLCVETIAMSHPSSPPPTGLAAKGAPSRAASTTAAAPPPDDLPEPSTTQELHLAAQRGDLETLYRLLDHPTDRTVTASDPDDQGITALHWAAINSHILFAKALLERGAEPDVRGGELDATPLMWAARQGHLAVVHLLIKYGADPTLVDSQQFNALHLAVHSSSAFLVAYLLNTLQPLAVDSQDPEGHTALAWACYQGDAISVELLLRAGADVLKTDHAGLTPLHWAVTKGNATCIRRVVQAGADLVARTNEGKTAREMAAELKSLPAYERGLQEAGLDPRDGRKEDLPFGDRPSAAIFVVAFVAFGAMFETFALLAWYTSLILVGAEAFAMHHVVSRVILGVRPASGKKHSHGHGHSHSHGHSHGHGSERVTKSGYLCAIIAASLAWVFYVWLSRFVLQLSGYSVTSLAFALLFLLCAYNFFRAITLDPGTIRGPVGGSEELKEVVEELVERGEFNGINFCLTCMVRRPLRSKHSFATDRCVAKFDQLSRLLFLFYCPWVWNDVGANNHRQFLLFVASLVGGVLLFARLTWAYFYEKAPDLAPDAYCPALVPALICTATKYDPFAYAVAFWACLQLTWTGILLGAQLWQVARQMTTLEVSNVGRYGYMGGKPASVGASSQFGAAVAAAMTPAGTATPDPASLAHAPKPADKDGKFAYLLKLLGLDRFTSRGKAISGLAHATRGDVVNPFDLGIRTNCVDFWTRGSELGVEYERLYEIPAGGFRRAMTDRRKSVSSVSAAAAAAAGTPGSAAAAAVKDSPASGLVGLLAGMKRKMRGYERVPLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Z3</accession>
    <name>A0A2S5B1Z3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional regulatory protein RXT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Z3"/>
    <dbReference type="STRING" id="741276.A0A2S5B1Z3"/>
    <dbReference type="OrthoDB" id="2538000at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="78108" checksum="778993B7E576BFE9" modified="2018-07-18" version="1">MAAVSASTSNGMNGTGASLSAARVDKVTRDSANASNPPATTTTPSTAAHRKMLAQRDVELLSLPARDQAAYYDDASPCTSDSELSDDGARDAEYDLARPTTLSAIPTTNRGHKLSRLAPHTRRGRLGYYPHADAGFDDGPLMSAGGDLSAGAREPAHKRRKLNDVAPSATEAGFPVAPNLQLVPRPVHALSRESDRPAPSYLPPVPQSPLDLLLMPSVQYSLGKKNQTFHLLGASATALIEQEAQLINALGKVCRGLRGDGYEWRWQGDDGRRQAKKEAKEESERKRAGALAAAAAPAENAQPAAPDAPPADPAPTDSQVGADPTPNVSAPASTSAAATPAVADLQAENVKAEQATPVLQPATAPVSATPVEHLVEVPGVSASAPEATASTSEDVEMKSSEPAVPAQAEAAAPVAAPAAPSGVAAVLAQGTESGAGGSAPPSVTGTVAGPANSPSEGGGAAVAARSSAPPSTATTAEGTDVPVSTSGEAAKDPEAAAEPTASTSNGTVAATLNGEAAGPAAGEADGTDASAAMEVDESVTADGTPAPSTAGGDDVATAAVRRRSGRVPAGGRGAMRHTRSRQSSPEDEGAFSSGAEDDAALYDDEALDGVRTTAARRNGLGGGSAGARAQLIPEEELPEYAERMVDPEGYVRSLFVTEGEKVELERMVPAPGGGAMPSGQFDSLTPNEQEVLLHDCMTDLHRFLADAIEYRNRLSEIRDGILGVERRRKGMWKVVRTVANDFLAEEEGAVYGQHAATQDSATFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B207</accession>
    <name>A0A2S5B207_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VMP4 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B207"/>
    <dbReference type="STRING" id="741276.A0A2S5B207"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="52835" checksum="45DE249E092D6476" modified="2018-07-18" version="1">MSSPDGFCLGRLRFIRLPPTVLFLQRGAAKRPQSLTVELAVGITDDYGTDLAFDSVELKLEALDADSLEPLREVQLQLEGFPQSPSRSPHASARFAFSPVQGPVLKLTTTLTFPPTFPARSMPTSLVFSLSAVPHPSEQPASDAPDPLQGSPSTSWIRETIREPTQVPLTLWDDRQAVLLGVRSGPVKIALADGPTRIASEKVQTAVRTIQLPAKQPLDSSAKGRPTTPAVQGGGQFAVIERPGLNNSTGQRLWDCAIGLSAFLAEFPDALDPQTSLATLSAEDGGERPRKRKRGDAKRTGSLRVVELGAGCGLASMAAAHALSTQGDRCASVLATDIEATVDSTLRENFVANGRLADASAERKRRDVSPEPRIKVESAVLDWGELSATQLDLVLGRRGASRATTSSEESDNDLTILATDVLYNTDSHSIFLSTLLSLLRPPTTQSSYRRALIAYKRRTDGDDEFFALASEAGLDVGKIWEWGEVSVWSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B211</accession>
    <name>A0A2S5B211_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B211"/>
    <dbReference type="STRING" id="741276.A0A2S5B211"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="282" mass="30304" checksum="1B78A6E7281CC38B" modified="2018-07-18" version="1">MVKAKGPADGAREFATALISHTAQGSTKRRPAGPMVPVLQDNWKTHKAACSAVRTGRPYLVHFDYKRETTDDAPWCKPLIDSLAIPYAKSFYTADSIEAMFEVLEHPIRPAAILCTTGEVAKRSNRQLIAKIRSYVSDGGRFVFGGPGVSAISMPLIDELFAGLGLAEWKVAQYHRTTHALNVAHPLFHALPADAPARFALPASYSTKAITLSVPTRDGLFRTDSNSKVESIAMMFGGGQISLGEAAVACTKVGDGWLSWVGDVNQEAGSTQAMLFLLGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B214</accession>
    <name>A0A2S5B214_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B214"/>
    <dbReference type="OrthoDB" id="2529892at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="263" mass="28490" checksum="CB77B06CD6D7D527" modified="2018-07-18" version="1">MGRDPLAVASAAGAVADTAAKADELALMSRFAAIAMFFTSTVAIISLAAFAVCIFSQREAAKWLSRSIWISWLVSWAIGAFGLAVYTASDTFVTGLCDNSESVSAEDETRKIAATGGAVFVTLALAFYFGIVLSAYVHTLHPHILMSPDSDTEDEYSDLDEGLERKLEGHLISLGEPYVSEYLAERKRRIGTSSADSTVSRRGYSRQRRRYTDEEASDTDAMQRGIDRGQRGLPLESPSEPYSSDASSSASDRDATPLRSTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B258</accession>
    <name>A0A2S5B258_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_6044</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B258"/>
    <dbReference type="STRING" id="741276.A0A2S5B258"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="558"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="188"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="501"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY70867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="613" mass="65338" checksum="E107C68E7B4F9F63" modified="2018-07-18" version="1">MSAYPVDPGQAIRWTKCPGYTTRLLDLVHRLDPVDRTLLFTTKGKGKQSIVADITDGLFTTGPHPDHSRVEKQRASVQRRINQLGSIYTSAIRRLKADPYSVHDTLVETEFPYWDQLHDLLRNHPDYPKWSLEQAEDALDGYNEQDGELGRADMQDVRFDHSPIATASGSEPGSPPRRAAPRIAAAPPTNANAVAGPSNPKPPPPGRDEHLFWNPPPAAAAAAAGPSSGRFSAPSSSHFRLPYALRADSGSGVASGSGSGSGAAAPPAKRRRTASPPPLPPMSRILQGRFEQAMEVVQSMGAEEQAQFVLDRIRAGKAAEQLEDARAQQEEEEAQRQRQLAAMAGPSSPRLSSDEWTAEELAELDAAEARLTGTGVAHPLPNAGRAVQAPDPVGAVAFEQAVPAPQPEPVIEAPVAAAPVPADANHDDGDPPLAECPKCTFPLSAVTPLEAEEHLRSCLDSDGAVLAECPVCEMALGGLANSEERERHVDACCRGLGAGGGGTTSSTAGGAAGAEGAATRGIGGSGLEPRKQKREHVVFVSDAKTVPKDEKTGEALECIMCFDEFEAEQRLARLSCYCLFHEACIESYWENPSKFCPTHRDLDTVPEVQMRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2K5</accession>
    <name>A0A2S5B2K5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000091">
        <property type="protein sequence ID" value="POY70986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2K5"/>
    <dbReference type="STRING" id="741276.A0A2S5B2K5"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="244" mass="26565" checksum="01F6C2AAA683DAC0" modified="2018-07-18" version="1">MTSSLRTLFRLHPRTGQWTRSPLTALNLNRHAAPSPPPPSRFETLASETTPIPSIQAPIQDDARGAGNQITPPSPSPAPSLGGPDLASLPNRFFGVQVPKKPAPPAEGECCMSGCATCVYDLYLDDLEHFHAQARQARTEILDQLRRQRQHRQEEATTVLAEWPRAELGPPPTEAELWSTAGADRVVPFGQAEGGGEDPAAVAEREAAAARREISDPTLRAFLEMEARLKKQQQQRTSATVEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2R7</accession>
    <name>A0A2S5B2R7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000087">
        <property type="protein sequence ID" value="POY71069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2R7"/>
    <dbReference type="STRING" id="741276.A0A2S5B2R7"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="240"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="540" mass="59890" checksum="26113E1D13F4D41D" modified="2018-07-18" version="1" fragment="single">EVPAQQDRVKVEGDDSASTAPGTSAAIPAGFEDVFAHFQLPGDALNNENGGDRTEGGGGGGDQKGQVIYSDDEMPSEDDDEDGEPQEMSKRKQKKANRLSVAELKRLVKKPEVVDWVDVSAQDPKLLIEIKSHRNTIPIPQHWSQKRDYLQGKRGIEKLQFQLPGFIADTGIATQRDAVKEKEEGQSLKQKTRERVQPKMGKIDIDYQKLHDAFFKFQTKPKMSEFGELYYEGKEYETKLKEKRPGDLSDELKEALSIPPLAPPPWLISMQRYGPPPSYPNLRIPGLNAPIPDGAAWGFHPGGWGKPPLDEFGRPLYGDIYGVVPNGNEGVGGDTIERDPWGELEPEEEVSEEEESDEEEEDEEPATPQDGLQTPSGLETPSGMASVTSTVPGGLETPDFLELRKRREETEPDYDDSGPKSLYQVLPERESRMRGFMGSDRVYDVSGVTQQKQGGPPVLGQEDRGTKRKAAGGVEVALDAAELEGLSEADLRARYEQASRAGRTHHEDFSDFIGEEVAKRRKLAESKKRGGDSQKEKFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2U2</accession>
    <name>A0A2S5B2U2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 11">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 11">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5854</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 11"/>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2U2"/>
    <dbReference type="STRING" id="741276.A0A2S5B2U2"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tyrosine--tRNA ligase SYY-like C-terminal" evidence="12">
        <location>
            <begin position="441"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="510" mass="54861" checksum="FAE664E9A96F0A89" modified="2018-07-18" version="1">MLATRREVLRSLLSSYKASPAGRHAVRTFASTRATRNVVRELEQRGMLSELTSRSAREHVEKPITVYLGVDPSARSLHVGNLLALIGLLHFRLYGHNAVALIGGATGAIGDPSGRSTERNALAPETLSANVESISAQLTAFLDRGVAFAKSRNRRRDGAQEGQATSEGSVRVVNNLDWTGGLSLLEFLSTVGKMARVSTMLSRESVKSRLDSSSGISFTEFSYQLLQAYDFLRLHRDLGCTMQLGGSDQLGNIVSGIDLIRRSNHVAEAAAKGVAAEAEEGAAKKEDPAFGLTFPLLTTATGEKFGKSAGNAIWLDARMTSPFDVYQFFLRTTDEEVEKYLRIFTFIRIVELEGIMQDHKVNPKARIAQKILAAEATELIHGAEGLNQALAATSVFYGTDLADLVTPEIVSALDGSPSSSSSSPAVPSMLTRLPRADVLGQHLEKAVLASGLLASKTQARKAIEAGTVQVNGQKVSPKSHQRMISEADLLDGRLLVLKTGKSAHKAILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B350</accession>
    <name>A0A2S5B350_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B350"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="110" mass="11152" checksum="657834065A37690D" modified="2018-07-18" version="1">MSSGSTSSASTASANHPTAHEERPSVDASPVRADASAEHAASGSTSSSSTTSFSTPPPTASSPSPDEKKTSEAAALSSKQGNGHGNGQHQHQGWREGPWRFDEEDGFGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3K4</accession>
    <name>A0A2S5B3K4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubulin-tyrosine ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3K4"/>
    <dbReference type="STRING" id="741276.A0A2S5B3K4"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52717" checksum="F4AAF3D690AEE5CC" modified="2018-07-18" version="1">MTTATDGKRARTALIAYPPSQAYVVDSLRRAFKAKLADWTIVSTRDQLADGAKPDLQWSDYDEIDWDWVMDERTLVNSYAIRKALIRKSNLAHTIALHLAKNPESPLRRAAPQTFHFTCSFADELDELLMDDLYEVEQSFTEAENGGEGKWWILKAALADKGNGIRLFSTRDTLEEIFREFEPESDDEEEDEDDDEEEGHGSGANGTSIRASPEAGRAAMFGADTRVDATQLREWVIQEYVSNPLLLDPSESSDEHGTKFHLRVYVVAVGGVTVYVHHPYLALFASSAYSLPSETASETGQFDLSAHLTNTCLQTTVLGQDAPRISVSTLQSMAGKVVLGGPSKGEKLGEERIRQIETRVCEAVGEIFKAAAGAGSSFQPLPNAFEIFGVDLLVSDTFEVSLLEINACPDFGQTGEELQEVIDQLFAHTIDVAVRPFFSAAGDGAASDKEALEDSFERLEVGGSRGLKEVMRLQVRKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3P9</accession>
    <name>A0A2S5B3P9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ER protein Pkr1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3P9"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12014" checksum="2045AF791C2DBDE9" modified="2018-07-18" version="1">MAAARTQDAAPRRSMLGDIVDSIFTPGTNSGLIRAMDMSFYALFVTLAALVVMTRGNGHVCALFALSIGLFVSIKWFLVQIAESEEQYRREQLAKEQQETNDAAKGGKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3S1</accession>
    <name>A0A2S5B3S1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3S1"/>
    <dbReference type="STRING" id="741276.A0A2S5B3S1"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117:SF4">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="41"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="343"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="595" mass="66230" checksum="FABBD9B2F8E07ECF" modified="2018-07-18" version="1">MLRTVRRGLEVASGPLPSKTRTWAPRWQSTSAAARPPIFRARETAVYPFGVPSNDPEHALFRKLSWTVADSDCWAILAPSSASSTRATVLSVLRHQVRFDPVSSAGHPILKALPPVKRPLEEGGPRDRTVDDLLKVVSFKTRLGHSGEFDDYTARYYSIRDEDKLTLRDHLIAATGASEEAIRRRADQLEMRRFLNLPLITLSNGQTRRARILRALLAEPELLILEEPFTGLDPKSRHLLSELLSSLHSQRAPRVLLILRPQDALPEFVTHLALTDIASNSDRLLLGPKHDMLATPEAQTMLEAGAAERTSLERKRTARREEALKREQGADAAGRTRRPLIELKGVNVSYGRPSEGQAERRVLKEVDWTVKEGERWVLAGHNGSGKSTLLAIILGDHPRSFTEDVSLFGKPRDRQATATCKSLTLRGARDRICAQADVSSQEIGHVSPEIFNAFPRKYGPDALTAYEAIATGFESVFSYRKPTPAQADTIADLLARLDHPRLTPSLLHEPFAALTAGDQSLVLLLRALVKRPPLLVLDEPFSGMDHETVKRVHRFLNEELEPEQALVLITHYEEEIPDSVGRVLRLENGAVIECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3V8</accession>
    <name>A0A2S5B3V8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3V8"/>
    <dbReference type="STRING" id="741276.A0A2S5B3V8"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="12"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="229" mass="25556" checksum="9123689399AEDD80" modified="2018-07-18" version="1">MATANVKRVDLEITSDSICPFCFIGKRRVEEAIRRAKDDKLPLDFHIRFAPFLLDPTLPASPGDNKRDRYTRRFGGAERVQKMEEAMIQRGLECNPPIKFSYGGVVSQTTDSHRLIEKARELKGEEGQLRLVERLFKTYFEEEGDPGSHELLSRDAETAGIMPASEAKAFLASDELKDVVAAGIQKAQMRGISGVPFTIINDKLAVSGAQETETFYEVFKKIANGELDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4L2</accession>
    <name>A0A2S5B4L2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4L2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4L2"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="211" mass="23499" checksum="7B357E9F01425D4D" modified="2018-07-18" version="1">MGISRSSRYKRAATGAAPSPYRKKRQHEAGRQPAMTKLGAKRIHPVRTRGGNQKHRALRLESGNYAWGSEHTTRKTRIIGVVYNATNNELVRTNTLVKGCIVQIDATPFRQWYESHYGQAVVKKGRSKEALAQVADDAGKGSNHVKRTLAERQKEAKVDPLLESQFAAGRLYACIASRPGQSGRADGYILEGKELEFYVRRLRSSKAKHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4M5</accession>
    <name>A0A2S5B4M5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5094</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4M5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4M5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="171" mass="18591" checksum="5E3DE003BE98CBB3" modified="2018-07-18" version="1">MARQPFLPLPTCKYTMSTSGGKSTSGTAKKGVRTEVKAGLTFPVGRVKRGLRKISYKMRIGEGAPIYLAAVLEYLVAELLELAGNAARDHKKARIIPRHIHLAVGHDEELARLLSSVRVGLSDLPLQLPNADSLDLALSTAGGVMPHIHSELLPKKKQKDKGDVEESHDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4R5</accession>
    <name>A0A2S5B4R5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5133</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4R5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4R5"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="46"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="287" mass="31700" checksum="F18D2ACFB5CB639B" modified="2018-07-18" version="1">MLAPTISTHCMLSRFAARTQLASRQRAFSTSAKSKMHVIPVPCRSDNYMYLIIDEATKTTAIVDPYDPPKIQAAAEKEGVKLGEYLLTTHSHHDHAGGNEKCAQLYPGIKVYGGGDKVAGLTDLVKHSDTFKIGELDVKAIFTPCHTQDHICYFVEDKKKDQRAVFTGDTLFISGCGRFFEGEPQEMHVALNEKLASLPDDTVTYVGHEYTAANVAFSKKVDPDNAAIQKLEKFCQENEVSTGKSTIGDEKEWNVFMRTSSKAVQDATGTKDPIEAMGKLREMKNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4V0</accession>
    <name>A0A2S5B4V0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4V0"/>
    <dbReference type="STRING" id="741276.A0A2S5B4V0"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1183" mass="121835" checksum="832F26B93FDC7504" modified="2018-07-18" version="1">MSHFLSSPTPSAPTSSAPLVDTPPLLGSPAQQPYSDGEEPSTTYFQGTPATAAAADAKVPPRQAAVGNKSTVAAHTVPPPSAPVPAKAAPPRATRSASTSAAADDGAGSTSHHGSIVPAYPYNVAMAPSAFVGGPLPDDSEVTTRLPSICVDYLSHDWAEDDVWTSWKAMTRHKAEIANGVRLENASWRTWAKQRGKLKTVSPETLNWLKDSDVTWLYGPLHTAVDAVPPPREATANERLGLESLRTISDSKKKATAGTPPTPDTPQSEAARAKSEEPSSAGSPQAGSSRGSAAAGAGKGSPTLRPSRVGAKAPTRRRKSDFHAKPILKYRSLSDILMPHGQPASPDIEATSMDFGDQATISVHHARSDSHLVRLNSLNRGKSGGSRRGSPIGSPMSSSPERTASDSSSGHAAHSRHAQHLAQKKKERRHISFNHRVEQCIAIDSSEDNRSSTYSTASSSDEDEDDVLTFGARSPRLSSYMRSGAAAAAQPKEPHTIARLGPTTLKSVEVYPAPSPAVVFSSDPNEYDPDDGAPSSPPEGSHGQQLVEEADYDGSVGTTGARQQQAQPAPQSAASNNRRVIYDYSTAESQARSQWDVDDEDYAMGFDYFTGPPAGPDVGVGDEYDMAQYGSTHLIGGTHNNYGVGNVGSSDPYLGHGPYSPSSPYHPGTSTLEPSVHATATQIPHYRDTLNGSSNSSSNNSATNVMGTDTAQPATGPHQPPPSARDAEPPKRSAMKGGRSREPSSESAGSSSPASSSAPSPPLSSLSSSPTGIQAIATAIPAHVRPAAARRASSSEEGERGRSASRGSSSSLEREASAARRSSTSISPAAYSPPTMNGGAGFFASSPTVSHSVPSASTTSTGAKPIAIEPTWKVAGSYESLDSVLSGGSRGPSSYTLDRQAQDAASGAGAYGAGRIITSSSVDSMGSLGSFGAGPITPTSPTFASPSKRFQPPLPSANGAHGADDDDDDKLVEDVDADPRAKPILPIQKVNSSSNVVATDGGDLTPMNAPSTHAPAGNVSASTVPPADHVRPAAGPKLRNPSATTTSPAVSAEQVPAQAIEPHKWDEQDDGGSSGLLKRTTSSSSLSFARQSLLRATRDTDESSPRSSLDSSEHSFTAPAAAPTPAPATASASTSATASDDLGVVDAGVGSGINVAGTARDLLGALSKGIWGSLGGGNRQNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B581</accession>
    <name>A0A2S5B581_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000064">
        <property type="protein sequence ID" value="POY71944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B581"/>
    <dbReference type="STRING" id="741276.A0A2S5B581"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="648" mass="70831" checksum="D7C2C68B074D141A" modified="2018-07-18" version="1">MSQPKDVEAAYDHHDNDLALAWSGLTVTAPKRPRPLLGPLDGQARAGELLAVAIAPDDRASRAHHGTPHAVMGPSGAGKSTFLDAICQRTPSARLQGQVTVNGSTDYDTREMFSFVEQDDALLGVLTVKETVTFAAHLALGPKYPNLEQHIDSTLQSLGLASIANNRIGTPLQRGISGGQKRRVTIACSVVAKPRVLVLDEPTSGLDATSGKEVVAFLRRLAKEQNVLVVCTIHQPNFDTFSLFDRLLLLAGGRVMYDGETATLPNYLASIESPVPEHVNPADHAIELVNTEFLKKDEETYGSMPPVSADDHLNALAAKWTEHRHATPDPRPSYGDTTTTTTGATLALGSRSGKRTGFAVGSQKTVTLMHRTVLNYSRNLLAYGIRLAMYVGMGLMLATIWVHLGYSTNKLNDRLSVSFFSVAFLAFMSVAGIPAFLEERAVFIRERANGLYTPGHYHLATTLVSMPFLFFCALFYTLIIYWAIPMNPGATHFFRFLLYLFLALFAAESQSLLIAALVPVFVAALALASFANGLWMCVQGYFIRATSLPRFWYYTAHFIDYQTFSFDLLVRNDFAGQILPCPVEPNGSCLCPIPSSLVAQGQCAVTGEDVLQNLGIAGVSDGLYIGIMLIIILVYRLLMWLVLILRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B595</accession>
    <name>A0A2S5B595_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B595"/>
    <dbReference type="STRING" id="741276.A0A2S5B595"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="467" mass="51288" checksum="12E1C1627817788D" modified="2018-07-18" version="1" fragment="single">CVEFDHTGDYLATGDKGGRVVLFERNENKKGCEYKFYTEFQSHEPEFDYLKSLEIEEKINKIRWCKRQNAAHFLLSTNDKTIKLWKVFEKSLKVVAENNSSAQAGPNPASPPPASSLPPSGLPSSPSANHGGGSDGNGTPYLRLPRMTYHDTIVAAVPRKVYANAHAYHINSVSVNSDGETYMSADDLRINLWNLNISDQSFNILDIKPANMEELTEVITAAEFHPVSCNLFCYSSSKGTVKLADMRAQALCDKHAKLYEEEEDPSNKSFFSEIISSVSDVKFSKDGRYLLSRDYLTLRIWDVNMDNKPVQTINVHDHLRSKLCDLYENDCIFDKFECTFSGDGKNVLSGSYNNYFHIYDTDATQDIVLQADKSAFKAKKIGGKNNKGGVAGGGGAAGGGKGGKNGKPIVDTENIDYNKKILHASWHPREDTIAIAATNNLFLFSKPGQSSSSTPSSGGMSGGSGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6F6</accession>
    <name>A0A2S5B6F6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6F6"/>
    <dbReference type="STRING" id="741276.A0A2S5B6F6"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="509"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="709" mass="73012" checksum="462BFF7E96A872B7" modified="2018-07-18" version="1">MASSLAGNTSATLPADETTSALTLSPLADPIAAHPPALALAPPVHLGEPLRGSDPASTDATDLSASPSSKPVRPPRAAQRPSTASRRTSTSGYESIAGTNPAAVASESVVPTDANASEGTTLVGAGGADSAVPEMSSVEKVDDAAAKAAIDKSAGASVPTAGSSSQTGPDADKRPSTVSQTVVADESTASTPKIGGAAAPSASTSPNNNLNTTAASTRSPAAAAGNASTPRPRTTQPTTPSPSAKKRKGGFSLLACLPCFGSTGHEEDPPQQPAAPARRVSPTPPVNEAEKDQEKVPVPASSDAAVDPPAEPAAVAANEAPPAVVESEKAVSAEDPNPQAAVTSPVVEPASNVVASTGDPVSQPLPTAPTANSGVVLPAEETEGVTSGAVVPPGQVAASQVPQAPTPTPRQRRRRAKQQQQARSGTDGIITSVPEPGAVGGGILLAPRHDEITSSEISTDEEDEDDLDESEEEEEEEDEEQMLIARGGVGIPIGEDGLPHPLLDELSSDLHGRKCLVLDLDETLVHSSFKMVHQADFVVPVEIENQFHNVYVIKRPGVDAFLKAMGEIYEVVVFTASLSKYADPVLDHLDIHRVVKHRLFRESCYNNKGNYVKDLSQLGRPISECIIIDNSPASYVFHPNNAVPISSWFNDPHDTELTDLIPFLADLSTVDDIRSVLDANLYLPSMGADGAALAGAGEADGISTALQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6I8</accession>
    <name>A0A2S5B6I8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000049">
        <property type="protein sequence ID" value="POY72398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6I8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6I8"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="762"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1081" mass="114845" checksum="7A1AF65FF7F10C19" modified="2018-07-18" version="1">MSSANLRLAEPVVFLVGGLDYERARQRQRRAAARAANQAATAETGVASPSPGPSRAASPERGTSGTRAASLSRPGSRAPSRAPSRPGSRTASPGPRGRLAQFAEDFVPPNSRGRSHSRTRQATPATAAAVPTPPSGAAGTPVTGDAPATTSNVEGLSRGRSGSLVREMTEAQVRLRQEQEQAALDEPPPAMLRGILSVHLSKPTRIKEIAVRFKGIARTDWPEGIGPRRLDVMEENMLINYTHTFFSASAAAMNRRAASIGPGAGDHGDEPRGRGPARRAASVAPGRDGSQGRSFHPRDGILHVAPSGATTASQSSTSLAATRSPRLSRLALDDVGAQHEAPPIQPGEAAPSYEVAVDSPIGSPLHGPSPHNSSVENLDLGSPAARSSRQHLLDRSNAPSLGSPLAAQPPVLSPSHSGTDLQRVSTRASRISHESTSTISSQSSGHTNRPSFARHASSNTAASAANSGSDVEQSGAGWNSAPVPGSTTSSFERGRFPAARHPSDSLGDEPGSLDRVTDGVAGMTFQSRTSLTRPPAPPAPASPTESRRRLSNASQQTARRASLDTRPTPPPPSAMKQGSGRSVSRGPRFLSGISEVLRGKSSSRARSNEPVQSAPASQRTASPDARRGEGSRVRSQSRGRKTALKALREALVVGHLHASHGHERDGSDEEGHNASDVIAVGDGWKEFKAGTYTYPISIPVAASLPPSLNCEFGHVTYTLKATVHRAGALTPKLTSSTEVLLVTSPSEEDTEENESIVVERFWETQVKYHVALSGKSFPIGGQIPISIRLNPLAKIKLYRITAQLEQKTSYFASVHSGRKLTRHETPKRFQLLRIENKDPKEPLLPILSDDPNVLANHPLREFFINASSSDDETPSLLDPIGPWHLDGVLQLPDCSNKLNVTTHHDKANISIAHTLKIMMRVERGDDEYLDSKGNRKLWDIVVEAGVVMLSCRLTQNILPAYTDATPSLSAPSGSRSNRNTTVRTATHTCGSETTSRASQLHLVPHTNSANRSGAPLATLEDTLLFSRLISGETTPAGETPPTYDAVVDGTAPVGRPPSVVIEEEEERRGRTRDSTRSGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6K6</accession>
    <name>A0A2S5B6K6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6K6"/>
    <dbReference type="STRING" id="741276.A0A2S5B6K6"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF89">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="783" mass="86664" checksum="0E441C1B8FD02B91" modified="2018-07-18" version="1">MSREYWQERAYRLPTEQQHAVDYVAQPYDATSSVAYDQQLYSHEGPAYHTIQHYAAVPYDRGATYSDHRQADIVVSQPGPSYVQEAAYDYGVQDGNGGQRSGLSNGASERSTFILPANGAQYAWHAVQQQRPPQIDAGIQLPLTPVTAVPSSKVDLEGAARASAAGKERKKASTVTRKCRPASCTPCRTRKMRCSRSKPCTACVNRGDPEGCLWEGNAVPLYTAAEDDEVTKLQAHVRHLEALLAALPPAKKRFPAAAARRPSPQASATPPTRPPSSECYDLTAQDLAGPLLSLITAGTVGPARAGQDSFLPDGQSSRGLLAECEALAAAASAEDQRSPFGPLAAAAVGSSAIMTPSPEGLLALVPPERELRVAYDFHWSNVASFYFSVNHDEIDARWPRLKAILDKRDPALFAAEFDPHFFALVLATCVVGRSRLPELVARRHGMSDDSAAESAAWGKIAAVFLEIPRDSPTLWTVQAATVLGIFYMSTSSGTLVTRGMRMFSLGASAALELGLNRDPLEGTLRECEEHRRTFWALFVFSINATSTTGKTWPIFDLRYVDCAFPQDYHNDELDLDEGAATARLRARRASSKFEETWITNQIHHFKIAYLAKATYDEVFAARSCSYEAVLEQDKKFVEVEAAMPEAYQFRNFHDEPLNITVQRGVIIHTCLSAEVMRLHRPFLSLAAIDKRFEYSRARCIKHARRTLYLYSAQWLLSFLPRFLACICILLDLMSGRTEEREGDLERVQYACAQLDAVRHKSPLHERGRKVLLYLLDRVQADGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6N1</accession>
    <name>A0A2S5B6N1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative (S)-mandelate dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.99.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.31" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6N1"/>
    <dbReference type="STRING" id="741276.A0A2S5B6N1"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033720">
        <property type="term" value="F:(S)-mandelate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF101">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME B2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="72"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="375"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="398"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="455" mass="49476" checksum="9901DD9D55F1DFED" modified="2018-07-18" version="1">MSTQPGGAKVLQQHAGKDATKIFKSLHPPGTLQKALPAGSLVGVIDVDDAAKLGGGKDDEEQRIELARASLRNVDTIVCLDEFEEVAQSILSQMAASYYGTGCRFSLAFPETEQTLRDERESWQRIRFRPRVMRKMRHIDSRTTFLGMPQPVPFFIAPAGLARLGHPDGELNIARGAAAHDVVQVVSSGASASVDEIFGAKSPEQIMFWQFYVPSDRVLAEKKLRHAIELGAMAIFVTADVPVLGKRERDLKLKARSQNYEHPIAAQWKAAGASDWNAVKNRGISDIPDTAHIDANLCWDDIAWIRQRAPGIPIVVKGVGCVEDVELAAQYGADGVVLSTHGGRQLDGARAPIDVLVEVRRRNPALLKQIEVYIDGGVRRGTDVVKALCLGARGVGLGRPILYAQSAYGAAGVSKALQILEEEVQMAMRLLGANTVADLRPEMVEVSSPERWVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6U8</accession>
    <name>A0A2S5B6U8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4312</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6U8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6U8"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="150"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="12">
        <location>
            <begin position="533"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="601" mass="65779" checksum="CC3BC3FCBB958668" modified="2018-07-18" version="1">MMVRMPLARVVAASQRTAFAAANSTQRSSFAFAATQANRLQNPDLVKQTATTNPPPSSPLHAGPAVIEGRPTVAVPPPPPAASAAQATASSSSSTGSKPPPPPKKPKNRVRTFARTVLVGVVLGSGYIIWRSYDQRHPGEQLPHDPSLPTVVVLGNGWGSTAFLKDLDNTGYNVVVISPRNYFLFTPLLPSVTVGTLSSRSILEPTRFLTRHLKRKTEVYEGEVYEVDPEKKTVRFIDNSEIKGAVSGTEIPYDYLVYAVGAENQTFGIKGVNENACFLKEVWDAEKIRTRIMDCIEAANFAGQPQSEIDRLLSFVVVGGGPTGVEYAGELHDFLKEDLGNWYPELADKINITLIEALPSVLPMFSKQLIDYTMDSFKENKIDIATKTMVKEVKEKVVVAQNEKKEIVEYPYGLLVWATGNTARQVTRDLMSRLSSTQNSRRGLLVDEHMRLIGADGIFAMGDCTATNYAPTAQVASQQGKYLARVMSKLHKKDQLLKELEQAKQAGAEPAKLDSLANAVIRASNIAPFHYSHQGSLAYIGSDKAIADLPVFSGNLAAAGLATYYFWRSAYISQLFSLRNRVLVATDWLKTKVLGRDVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6V6</accession>
    <name>A0A2S5B6V6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6V6"/>
    <dbReference type="STRING" id="741276.A0A2S5B6V6"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="739"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="957" mass="100469" checksum="D3C646C078C665E4" modified="2018-07-18" version="1">MHATLPTHVLALAPDSIATIGTLSPESLAELWAVFARCKDSLENGRRLENLSWRLWFDSGRPGPEPPLAPAGQNGALVPEEWSDPEWEETSSCDSDAASSAGEEVANGDALARSGRPAVARKARTTGSTSVSPQNHLCRRPRTTSVPAAAADPSIAAEQPATAAGRPSLARRGYSREGRPLHVISGNSLQRMIADLQRMPEIPPFGKARSLSDIQASERPVKPPLGSRGSSAPDGLSNSSRHASAPTSPTLPSDELEMPSKMRSRRTSSDVSPALSRANTTPAPSTSNVTAEPSAPISALQRRFPSNLAMSAMPRARRSRPATPASSPPSRDGADIPLTPSETAMLAVANSRNRSDLNLSKRTQSAADLAASFKPASYVKGFEPSPTSLNKATESVCVPASVDARPGPGAIAPPPTPANHAAALAPSPPRNAAISLSPRVHRTATRTPASSLVSPPSKVAPPAPSTSAVSAAHSHQSTASAGPSAMQGTRRKAGAASKKIFFISSPDSDEEHSSRSRSSGMKVVITPPTALRGAAEQAARASTSKPAANAVASPPPPPPRASTSAPAGAKPDDDDEWASDSEDDSSGWGSEYSTESDEPRQGARNGTRSQAFDAKTAFAKRAPSDLQRTASMATVSGSGSNWGGGPGELRRPGLLSQLFHPDQFIEEPEQSRSSLDVLRRKHQSSPALAMLGRQGSDTSVKRMPKTARTKSFLKGKPENIELESSSEEDDDEEDAAQAAALAEAEAQRNAAAALARRQRELEEVVAPPQTPRTTRRAMLATELSESLRRNLLWERQTRNKVLGGQPRRPMMPGEQLPPRPASSTNLAQQGAPQAPPPPPPGVMRFQTDNPAGTQDRPNGSSTSQAPPPRRSPPVVTTTVRKEEAPRERHGGTAALPRRHTTGTGLYLQAQLGGRFPGGLRNKTDGTDSDVSDSSDDDGGTASPADAFGSSTAGQRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B728</accession>
    <name>A0A2S5B728_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B728"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="202" mass="22092" checksum="9A01112458771433" modified="2018-07-18" version="1">MSPPRGVCTCGCMIAVDGKDDLDRSRGPTSAGRQGQVAASDDFRRTLDRCGTWGDGVGPAVRRRLFRNASSLGSVNRELRIRDHGATWRSARAGCLARVGLRHPESDPSDQQLARDSIRTRNAFLTKSNFALLSPPSTTSHTLFAARRQPGTIRLSSTHSPAITCLPLPPRSRLLRPVTPSIAHPRRRRRRRSAGNRSSHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B734</accession>
    <name>A0A2S5B734_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B734"/>
    <dbReference type="STRING" id="741276.A0A2S5B734"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="216" mass="24287" checksum="C1E030D03191326A" modified="2018-07-18" version="1">MPNQGNGQVWLTSKVMGREHGTEATRKAVDDSAAVAEKYGLKWDLFLLHDPTAGREKRLQAWKVLIEKRDAGVLHSIGVSNFGVEHLEQIREAGLEVPEVNQIELHPFCQQKRIVDYCEKEGIVVEAYCPILRGQRFDDATLQKLAAKHKVTVPQILIRWSLQKGFVPLPKSDTPGRIQANADLFDFELDTSDMKELDALDEGKKGAISWNPVDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B794</accession>
    <name>A0A2S5B794_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B794"/>
    <dbReference type="OrthoDB" id="2526907at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="47875" checksum="C1EFBDF3C4A824FC" modified="2018-07-18" version="1">MPDKKRINLDAQSSRDENEPRAFPHAKIPGEILSRIAFWAYKGQGVETLLRLGSPNRAWRTACEPLLFRDLVCSDVSEVVGAAKVLAQPAGNEADSPLRKKGSILRHVEHLQLILETAFPTNPNRPTLLGAMATVCSECTWLTSLRVQARSGAVIQPFDALFPGGGSARKALASLSHLKLLVLDNIALWLHELTVLMLGWPELQALAVSCLRGDCVRSSSTSTDVLPCRLRNLRVEQSTLTNEMTAHLLRDQSNLRFLSLPVQGLTGRTLAELEKVMPNLTTLDVRDSWASSKLRARSKTPKKNDDKVAEMDKDDLEQDEVTLPLTSLFRLLKSTACPDTVHLNRTLAPSDFFEEKGISQLTACMVEVENLSLDDFPPTSSIYGALAAALKADDLPFLKSIIVTSSTSATSSAKKTTQSKGLKALEAVAKARGVTVNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7C9</accession>
    <name>A0A2S5B7C9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7C9"/>
    <dbReference type="STRING" id="741276.A0A2S5B7C9"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="104"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="187"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="306"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="391" mass="40203" checksum="9EA1BB83BC726973" modified="2018-07-18" version="1">MADSLTTANDLNRKRSRSSSPSNDSAAKKANQATAAPAKLEMDEEDDKAAAAAAAAGDGVPANGDNKADGGVAPMNVDSSGIPAKPVGAEVSAQDAQAQSQTAQTITMRTLIVTQDASVIIGKQGKNINEIRDKSGSKLNITESVPGNPERIMSVSGPLDAVSKAFGLIVRRINDEPFDVPSVPGSRAVTIRFIVPNSRMGSVIGKAGAKIKEIQEASGARLQASEAMLPGSTERVLSVSGVADAIHIAVYYIGTVLLEHPTATGNTSYRPGSGDFGSRPPADRSGPPRTGGASGGTGLGPAAGPGAQSQAIFIPNELVGSIIGKGGAKINEVRQMSQCQIKINEPNEPAPGGGPNERLVTITGQPTGIQTAIQMLYKRLEEEKNKQLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7J3</accession>
    <name>A0A2S5B7J3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7J3"/>
    <dbReference type="STRING" id="741276.A0A2S5B7J3"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="655" mass="72361" checksum="832412BDAB271554" modified="2018-07-18" version="1">MSPSLRRNEALGEDEPDDGDLPTYDATVNDPPSYGAQRLVSVTAVAAHLDVLRRFATIESSVRACSTGSLAPLSPSQRWAAYLRLAAVRLEKWVYLIAEARTTRRTWEEQVNALPDDVALVWHAWMIAAPRRYEDDVRRVWWDSLTEYGSAAGREAPLRGFPLILLARRFASAGAGLAEQEGQQLWIRKTGLAWDGLQTLLDPEPLIRYQCPACETELKTPALTPEGTGFCDMGFSAVCTNETCFHGGDSSPCITRETLGVKRLLDDLRLEPPLLPDTDSGWPVAKQRELQGKAVRRLAGGILSLTSDRYSWSTRPTSYSIVSATLVHRDFAKAVLRGPDNGEAAPASLKRLEQSLLKDTKLSSRVILHFLSAYTSPHAWSTDIAIAARRLSEFTRALDALGWLGPGWSTTNIGTRKLQQCIERYSRTLELSGQITAKGPLVVPLDVDLVWHTHLLQPSTYRRDVVEMSGTFLDHHDALEETIAAEAFDRLARAWIKSYKQQPFSAWSAPSAAGISARLKRLARTPAPLTALTAPESRPSTHSSVLVHVEKQAARRNRRIEGDLDPPFLRHRESDASDGQTDGIWCVTEATASLAGSNILGVDGFSPPTCWDSYVHHAAYRPWHGPSDAHSSVERDFGDAYRRPAPSVPIGPRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B820</accession>
    <name>A0A2S5B820_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4068</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B820"/>
    <dbReference type="STRING" id="741276.A0A2S5B820"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="459"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="503" mass="55794" checksum="B2805EA6EC4B43C7" modified="2018-07-18" version="1">MHTVKTSHDNQVSTTVYGSRAAATGIPRFEMGEEEMDPRLAQRFIKDELLMNGLPALNLASFVTTYMEPECEQLMADALPINFIDVEEYPAMGEIEARSVAMIARLFHAPLDNPEAEACGVSTVGSSEAIILAVLTAKRRWKEKRMAAGKSTENPNIVMSAAVQVCWEKAARYLEVEEKYWFCSPGKYLADPQELVDLVDENTIMVVGILGTTYTGGYEPIKGIHDLLVEKNKKDNLDVTIHVDAASGGFVAPFVNPDLVWDFQLPLVASINTSGHKYGLTYAGVGWAFWRDKSYIPEHCVFTVNYLGSPQASLTLNFSKSGVQVVGQYYQLLRLGKSGYRAIMQNATATSDYLADEVAKMGDGKLFHIISAGHGESLPLVAWQIAEDKPYDEFAIAAHLRQRGWIVPAYTMAPHTEKMKLLRVVVREDFSRSRCETFVRDLKETVHYLENAPAEVQKHMSKTQAAGDEGSKHHPVNTSKKTAVHANEKHSLRGKHGKTHAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B864</accession>
    <name>A0A2S5B864_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B864"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="56334" checksum="A33F2F60444D17B0" modified="2018-07-18" version="1">MPPVAPPDASPTSDRGPCPCALLPIELLEAILAPQFDPDGGAVTANAAWRAPAQSQRERIRLMTNYSLVCKAWKPVVERLAFETLYLHLGDRPLCEYLDPVGGAGARLLQYAQSIVIAALDSVEQHSPGGPSDDTATEEEASSSDLDGEAAASQPDELAEDEPEESSDADAPSPETGEIARRGTEPSSLDLERISRILDALVRPREMSCVLHSQAALSAVLSVHRVQRTWIAVWSLSILWAGRIRAILPSLASFSTLADLATLEISVNSSTEPLEPARSHISLTLQPLRALKSLTLVCNEPAEELAPIARLLPADLRTEKVKWAGRLPANFCANLPPGPPIDFLFLACPANGDDWIDSSYSPLKDLGHRGIDKLSIILPAVNPEISSRSLKVGDLLDNLPTNVRFIFSLEADDEEALEQYVYGIDDTFMRIFQAPHAPKPAPTGRCPGELDYSYRNKPLKQFAQISVNFAPLARTTAPWGFARYGDDDSSASATDWMMVEPEDWNLFVDWIAMQSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8D4</accession>
    <name>A0A2S5B8D4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8D4"/>
    <dbReference type="STRING" id="741276.A0A2S5B8D4"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCH" evidence="3">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Muniscin C-terminal" evidence="4">
        <location>
            <begin position="786"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1048" mass="108104" checksum="AE33F8D6DC81F064" modified="2018-07-18" version="1">MSGNSSLYADAFSQARSPAQAFHAVDQRLSLERALTADLAGLFNERAQLEHQYAKSLQRLQQRINATGQKDNVYKELEAVGGGDMRTVDQQLGSAWTGLRLSIENELAESARVHQSWADKLVKDVGEPLRTSVTKGDWARWNATEAQLSSQTREYEQALEKMQKQQAKSTKSSKSSQSQKLLQSQSTLSTLGSSLTSALPAFYDQSQRLDLSHGAFLKEALVRCGTLTSDLGRERMEAGERLTVQVLGIDESAEAEEWALRESIKLGSMGGGGGASAGAPSTRSGTMPAIGEFGESAAPASAGLGAAQQTMRQTRSGSVVDDAASTRSGATAQTNSERQRTGSRSGQAPPAAPLPLPTTDDARSTKEKRGLGSRLSTLIGGNKSRDRSSSIPNSARYADYSSASYQNDATTPRQEVPPPVPVVSPNVLASEPAYPNSAPSLDRRETDSSDLLGGGAAAGGMAPLMPEPQGSRRKSLMPGSGLFRRASKMSDSSPLGDGPASSAAAASGAYGGRGSAFTSEPEQHDLHASSGTGLVDADGYSVPPQGYDRSIQESAGIARPNGQTSLLDDDDDDEPLGQGRATSVPKLSIVPDLPAGGSPVLPQELEAERLAALESMKNSLGSSAPGLAGGPAGVNRRATARGRRGTGSVSPQSSVPVPAVAAPPLLAERQDSDDIPLATVVQQKTRREAPPPPPSLAQRDSAITGAAAGAGVAGVAGLGAAALASSSMPSSPAGSSFSPQALTGSAMQPTGPGRTMSILSATSSVGAMSSSVHGIRPDPFANETSPGLRANIVETVNVLLKGGEVTRVLVTGEIGLSYRSPSGSTTEAAPGNLKIRLTGLDSLEKKAPNPALLQPGVEAGEFLISPTITAHGGATTTVFKYQLALSASTTPVPVLVKPVWRCDPAQARAIVTYAANGQSPLFASAASPFGEDDEEGGAVASLEDFRLELTLANGTISTFQAKPATAALAQNGKALTFSSLPALSLASGEQKLLASLATDGPAAPGPVNVSWTLRGRTLGDVSVEIADGHDVELVEVRRETISGRYVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8T5</accession>
    <name>A0A2S5B8T5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8T5"/>
    <dbReference type="STRING" id="741276.A0A2S5B8T5"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="701"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="961" mass="103956" checksum="1F45B070638B3004" modified="2018-07-18" version="1">MAPASDYFSFGLSGTEDHMRGVGADHLLTPSEALGYLSPLDSPRLAASGSSPRSKTASIQKGLEEATSEPISSEELKKRLAEKEQTKEARLRGRQLSPSQLAAVLSQDPSPAPPPQGRFLHGGPPLSDLEAPSAALPNSEKHNKPIASSEWRAFSDDEEERLQAAWRAFQQDTEAQRRRDQRKGKETVKGEGGTRRVNEDEADPADSPYLVPVGLDNLFTVSLLHNVLYPAFWTGTPVRVLLCHWFYAPPSPPPNAGSLSSHQIKPYPVDPSLAAALDHAYSSIRPWDDAYAAELASALKGGKEAQQRLSVALGVKNEAGTEDNLGIEVIFENEGRGRVYSKGMMASVSKAFLSSGKSLGGGQVVLRGWDALRDYLEEKAPKKPTPKSVPAAADARPATPENDRLAPSTASPEKSHSRSGSDATSPARAANQKRSESPSAGLFASLRNRIVGAPAHGDSAAPASTAAANATAPGSAAQTALPNETQEAVQLRQEEIGAPDELVLVIHGIGQGLASAYNSFSFVYACNAFRSACTTLSTSPALSPLLNGKRAQFVPVLWRAELDFDEVDESADAADEHLANRFGLADIEVPNSIPFLRQVVSGLVLDVPFYLSPSHKEKMLRSVVRECNRIYTLFSRRNPDFEKKGGTVSIIAHSLGSVMAADILSNQPTFVKQPELSVRTPGPRVTSDKPAVGAKQDGLTFAFDTRVLILVGSPLAFFLHLGKGQLIARRGRERTRNVGRDIALDRAGRLGCLACDSVYNVYAEADPVAFALNAAVDARYAKLIKPVPIPSTNQTLLQNLSDAYHRVSRIFDMSSLWGGGAAAEAKPNADQAKEQADEQAAKHDGDKATKPLPPRPLAALKRMPSERPRFGKGTDHFEWVERAEKRMKALNPSGCIDYTLPSESSISQYLDALTAHQDYWADRRFSTFVLTQLFADESYLEKTGREEVGIREEDEEAEEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Z8</accession>
    <name>A0A2S5B8Z8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase assembly protein COX11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Z8"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Z8"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30913" checksum="48ED3B9012B3EDD9" modified="2018-07-18" version="1">MQRSIPRFVSPALRSVRTPIGAYSPCRRVAPRPLAGSFSRSASTAPTTQAPPPPPPPPPPRRPNPAAEAYQRAREAQYKERNRSLLLYSAATILVVTAGSYLAVPLYRVFCSATGYGGTPQTDQSRFGPERLVARTDLGSRIRVTFNADASDSLPWSFEPQQKEVRVLPGETALAFYTATNHSDEDIIGIATYNVTPMNIAPYFAKVECFCFEEQRLLAGEEVDLPVFFFIDRDFVDDPLMKDVREVTLSYTFFRARRDSYGNLVPAEGPLAVADSVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B943</accession>
    <name>A0A2S5B943_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3619</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B943"/>
    <dbReference type="STRING" id="741276.A0A2S5B943"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="553" mass="58968" checksum="922F96698F6F961F" modified="2018-07-18" version="1">MASQSPYPPAGFQQPEAPQATYAPPSMPHPAQYGGNAPATNGYLNGNGGAANGYYAGAPEPAYNNQYNAPLGGKTQESQYYQQSQAAGGQGYNAPPPKGEVIEGKFDDVKPKWNDLIFALIFLAQLGAFIAIAVISLRALPASESTGGLGSIGSATTINASIGWLLAITAGLGLLLSLGLLALVRFFTKIILEICLVLSLITTIGYAVYMWIQKYWSGAIIWTIFAVFAILAYPGMRRRIPLSKQLLIYVIRVAKVHPSVYIIAIIGATLVTAYSAFWGIAVAGIYQKWEPNAAGSGTSGGTPSYGAVTGLMVFAVFNLYYTTQFITTEAGIFGAYYYGGADAKKVAWGSFKRASTYSFGSIAFGSLIVALLDLLRAILQLVQSYESQEGNVIGMAIACVAQCCIGCIAWAVEYFNRIEIALYGKAYIPAAKDTWRLFKDRGITALINDCLVNNIWSFGSLAVGALCSLLAFGYLKGTDPSFIQDSSGLVAVLVGYSFAIGFFICHSLGYGALSSGVSTTFVALAEDPEVLAERDPELFELIRRAYPQVVTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B951</accession>
    <name>A0A2S5B951_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3636</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B951"/>
    <dbReference type="STRING" id="741276.A0A2S5B951"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="58"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="531"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="594" mass="63072" checksum="24A62C93D624B0F0" modified="2018-07-18" version="1">MNASISPRSSASEPLSPQTAAASLSWSPLPNVRDDEADVAEGSEAEGEGDLTPALVRVSLVAGLGARVDGSNCSGFDTGVTSSALLAIGTALGGTELSLGQQTGIVVAALWGALAGSLVASRTADMFGRRPVIIAAAVLFLLGALEQAAAQVYKEVILGRVLVGVGVGLSSMTLPIYLAEIAPSKFRGRVVASLVVLITGGQVLAYIIGAAFFHVTKGWRWMFGLGAVPAGIQLLLSFSLPESPRYHVRKGRLVTATKTIQRLNPSFTNEAVQRRLLSLQREVRTLDPVIDRAGDPRQLLSSAIQKTRSWRLSRLKEGRLGRMWEDRANRRALLVAAAKIIHQTGLGQPAAFAIFVAVSNFVSTIVALRLIDRVGRRALLLRTLLGMIGGMALLSFAFIFIHLAPETEEVATIARAPSPWAFVAVFAMCIFCVSYALGIGNVAWVVQSEVFNQELRALGNGLATAVNWSANLVVSSTFLHLSHAATPAGAFGLYAIVACVAWLFTYLYLPETKGLSLDEVRALFERKVGIDRGPDPVSDRQPTGGDSGYYVVGDEDSSEPEDEAEEGGDPDRAISEPELAPSPNAPTKRASDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B960</accession>
    <name>A0A2S5B960_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septum formation protein Maf</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B960"/>
    <dbReference type="STRING" id="741276.A0A2S5B960"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="25798" checksum="9A98CAFEB78D96A1" modified="2018-07-18" version="1">MSSAPLISATRSDPVLPSALRLPLFNKLRGKHVVLASGSPRRLDILRTYGLDPVVCPSSFPETLSHADFEDPAQYAVATGSAKALEVYEKLVSESPEDPPDLVIGADTVVILGGTNPAILEKPSSKGDQLDMLESYRGADVRVATGITLVRPQLATPGYSCTSLVVESRVIFAENSPELLDAYVECGEGIDRAGGFAIQGMGGLLVERIEGDYNNVVGFPGQAFFRWLGEMAEEDTLLEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9E6</accession>
    <name>A0A2S5B9E6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9E6"/>
    <dbReference type="STRING" id="741276.A0A2S5B9E6"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="291" mass="31300" checksum="D13E874C7D437EC9" modified="2018-07-18" version="1">MSPSTSTTGPILVVGATGKQGSAVLRALRAQPNAPALRALTRSAASPQAKALQQQGIEVVTGTLSDVESLKRALIGASAAFLVTVRPAKGDIDEDQQGYNFIEAAKAVSLPFLVFTSVSDATTTCGVPHFETKAKVEVALKELGLKHAVIAPTGFYDNFPRQASLGSFFGMGLFDAGLHGRPLKMVATDDIGEVAAQTLVDPEAFAGRHIKLAGDDLTMAQVRDTYARVEQRSVWKARLPSFVLYALPYDLRSMFTFFADKGLTADVAATKEEFPTMRTFEQYLREGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9G1</accession>
    <name>A0A2S5B9G1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9G1"/>
    <dbReference type="OrthoDB" id="10386941at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="114" mass="11202" checksum="A42ECB5A7DA9D808" modified="2018-07-18" version="1">MSNQQPTQILCGVNCACAPISAPSPAVSTATKSCSARESCSYAQSGQCACGQSRDASCAASRAKQGCAKAKEGQCDCPAGTCKAAESARSACSQKSSGACDCAPGQCKSAGYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9L1</accession>
    <name>A0A2S5B9L1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9L1"/>
    <dbReference type="STRING" id="741276.A0A2S5B9L1"/>
    <dbReference type="OrthoDB" id="3270176at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="278" mass="31260" checksum="B9EAD651CC4326DA" modified="2018-07-18" version="1">MADGKKEENSNSCALCEQPGTMRCGRCRNILFCSSECQRRVWPVHKGLCGGSTKYFRQAPLTKDEFAYVEKVKHLKVLPPIATAMYQNAPIIPLEEILVDECPGVKSWAHSATFLKSTSAEADTAHTRQDVDYSPREMVILGARKEIRKRGKIDGNQLGGIQPWAQAAFMTGTTTSIIIQKEPGSHESFDDDGIPISGHRLNAFLRQDLIFSLLLDDIVHTSNRKTPEYARTVELWKLAAQRVVAELDRAPIHRKTRRMIRDEVDTNIDSAHDMMRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9L6</accession>
    <name>A0A2S5B9L6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9L6"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="252" mass="27806" checksum="70B52296337992D4" modified="2018-07-18" version="1">MSTVTAQTCALCEAKATLKCSACRDVWYCSAKCQKTAPLSEAEMALLFQNKNVPMPPTHQASFMDMRGRSDSDWPRRAHHYEAIDVQLVVAVVDRMFSSVREQSIMMARLNIKALSDLSANGLPATVSSTAAWYDMAAFLAPAGRAFYAANPRMHTAVTDEDPTFETVLNGYLRALLALSVVTWNAILTSSRVSSLEDSEWYPLLQLHHERVEKELVAATVQSSVKDTLRQANRGRWPIAPRAPGSPPALHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9N3</accession>
    <name>A0A2S5B9N3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9N3"/>
    <dbReference type="OrthoDB" id="10664900at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="198" mass="21532" checksum="91C3B65882AB5A51" modified="2018-07-18" version="1">MSALTPATDPFRVSLPALALDTRVIKRYMPKGSRPLTRSELILHSGVPDQDLTDSRTVVSESPCAGPASLQKADIKGQRSTATQSSATRHTFSWPTPGLLQAMVQGKNRHAMTWASNANGPLIGKSSQRYSVQLRQEIPVDVYASQWQAPPPSIVWIASFHVLSQFGTVADAPLFGLSLCYKLDSVAERSPYDPGQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9R1</accession>
    <name>A0A2S5B9R1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ThuA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9R1"/>
    <dbReference type="OrthoDB" id="3482285at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469:SF2">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469">
        <property type="entry name" value="SECRETED GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA-like" evidence="2">
        <location>
            <begin position="32"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="335" mass="35629" checksum="BE2D01EC3356BF99" modified="2018-07-18" version="1">MARTFRLARKVLAVAGLAAFGSSFVAAAPPQILVYYATAGYYHESIPAAIDALQNIGATSSLYNATFSEDESLFTPDQLRPYSAIVFLSNSDQVLTDTGEQALSQWLTQGGSLVGLHAGTACLFNDTAFGTAMGSWFDYHPTIQNVTFTKLVNHSTVDPLPDRYETFEEVYHFRTDPCDVNCTVLLSYDTSTVDDPQFGTRPYYQGSPPPIAWYREGQQVDLGNGTQAEAPVMTGRTWMTSLGHTIEIWSDPTHLAHVEAGLRWALEPFENAASNATASSSAVSNSASASRSAGASTPSSATSSSTPTQQATSGSDRRASAAAGLALLGGLALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9Y4</accession>
    <name>A0A2S5B9Y4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9Y4"/>
    <dbReference type="STRING" id="741276.A0A2S5B9Y4"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="403"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="821" mass="92096" checksum="4F9B53ABDE78B6CF" modified="2018-07-18" version="1">MAISKPQKRPQGATTLPTSTASLAQRVEPTDIDDHNTLTSTDDALFDPLRPTATSTGTSTRSRRASPSSPPVPSTSLNPATAALTSALRPAADSLSARGGNMHNAQAWLSTAPPSALGLTNLVALDLQVPQPPVSVTVEPTTENGHARHRASHPTHKASQQRADVDHGYEGETQQSRDRREDNHHLVVPHSYGPRDYLTGPADELVERLPRPSPLSRSASALPSPALSSTSVSTPGATLPDQDISSDLFRRAVDQRLNAAAAPGGGRRTLGLEADYDDEADYCADEAQTLLAEDSTPSRPRPRAFTLSHSAFGSFGTFPSTARSGPLAAPTLRSRFKLFWLQLFANAASAAFLILIVIWALSARFFQASYRQLRGLTTPRHRREWDTDEARAYRKTEKVVKDIQYYARRCGFDVIEQTVETKDGYLLKVFKVECLRKPAKVHSDGRKGFPVLIQHGLFQSCGSFITSEERSLAFWLAEHGDYQVYLGNNRGVFDMGHSWLKRSDPRFWDYNIKELALYDLPALVDHVRRETNYDKIAFIGHSQGNATMFCSLAQGMVPELGEKLSIFIALAPAVYAGPLTTGFPFTYLKSMKWKTWRRWFGVLDFIPLMRLSYNWVPSRPFGLLGYQMFAFLFRWTDANWLLDRKPKKFCFMPSPVSSASVFWWTGYAGFSTRGCILDPSADKWFDKRFPPLVLHHGGKDYLVLAEPLLERLKVHETDVQVIRVQKMDDGEHCDFFWHIDAVELCFRSFLEDIERTRPRYPEERRRAHSPQPPAHSPRLSGGSTPRDHQPLAGMQKAGEVEERQRRGERKDVEVKRSEEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAC1</accession>
    <name>A0A2S5BAC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAC1"/>
    <dbReference type="STRING" id="741276.A0A2S5BAC1"/>
    <dbReference type="OrthoDB" id="2587928at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015466963" evidence="1">
        <location>
            <begin position="24"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="753" mass="75462" checksum="209F970A009E8AB4" modified="2018-07-18" version="1">MLASSLGSAIAVAYLAFSPLVAALPRPVALEPTRTSLYRRATTTPSVQLTPPSFLDGEAMRAMLTTMGSSKSERSLVDGDDSDLSKRDDNLVRRATSSCIDSTGNDTLISSLFHYGGAGTTVELCAGATINLQNAIFFTAKNQVLTTQGNPTDDSRAKLVVKGSDQSVAIYTACQWCDNVVVSNLQVYGSWLEMGYNGGAGLIEAGGDTVGQVVKNCKLMYPRGWTALHGIEGDPVGDSRWCSSMQILNNEVGPSGAGPNVGTLDGQWADGISIACKGSTVTGNTITDATDGGIVIFGAPGTTVSGNTIISATRGQLGGINAVDFNPWGGTFQGTVVEGNTLIASGAMMKVGIAIGGMTWGSDNRTAARTFGGTFRNNVFKTSGSGYFGFGISVAGHNNAVVSGNDASGANFGGKSSQWCVQNILPPTPQAFVYDQYTTTGSSVQNNAFQAPLVFVICQVEGPVATTGNSVGGGLIVTPPQNASSSAVPSAASSSAVSSSSVVSSSAISSTASSSAVSSASASSSAVSASSTVSSSAVSSASASSTASSSVVSSSTVSSSSVVSSSVSSTVSSTVSSTASSTVSSTASSTVSSTVSSTASSTASSTVSSMVSSSAVSSSAVSSTVSSAAVSSTASSASSTASASKTSSSAPAATNSTSTPAPVRMTWYMWLLWLANGAPVDSRGQPIVKSAAAAVVATQSVVKRPTFYDLQSAARAAAAEATRGSPARLARRFSRETPSVNLINPFAAQPTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAE1</accession>
    <name>A0A2S5BAE1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAE1"/>
    <dbReference type="OrthoDB" id="2530132at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="387" mass="41293" checksum="796C65026F33BF30" modified="2018-07-18" version="1">MARCRQVVVDEVRAAQLRHASSSSPAPSSSSFDPNDTRHFAPHILSFLQSAFDSHPTRRLNKTERKELARAAGLSEKQVSTWFGNAKQRERRRREREATGSSGSTLTVQLQPHRRTASARTVPYDIDMAPHHRGEASYERQQQLQQSRSWSSSSFRSSSHLGSSVSSSSSSWSAASGSSIDVVEYAESAADSQFWPAASESSYPPGDLIVDSSSWDLSAFPALDPSGWFSSASSSAAGTREAAPSPASPPLLVLPPELDPNAPTPSSWSSTCASSPSLTFDDPLDPPGAADSFALEYPFPVTVPAPADAWMDEEFYRNLFGSLGLEMDGQAATAGGTTMATMDGGGFEALLGELGGFGGDEGATNRAGGITLSMDELRRDGEEMLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAE7</accession>
    <name>A0A2S5BAE7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAE7"/>
    <dbReference type="OrthoDB" id="2548253at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="705" mass="78095" checksum="16DE2F50E7D95188" modified="2018-07-18" version="1">MTEPDRINAPYLPLEGGTVPRARRKAPSKWLTPGRSCLIFCGLLGLLCTTGVGFLVYKVAAETWRTLNIPHGHTHANASLVAPHGVVPIETDVVRSFFGPQKDGGVDKFDLRAAIWARVLKPYVHWDDTPWALVHDSIVLKDVPIEAKALHTVEQVRFPKSLVNDLATSMTVGLVATFVMVPAADRIDPSLDHHTWRTSRNASFFGVNANLPPLSPEMIEPPKDVFRRFLANAGAARSLILRPSDDPMLVEQARINGSRADELFATRHLVTTSRVTMARDFPVYNFTAYNETLLQRSTFMRDFCVAGTGRVECERSFHNVGHFENLVEFDDAEDGKPETATRRGWRYGPFLTAGLGNPGPLEHRAIHGNETEDFLFDWKIIYTAAGPGKISIGATAVNALEGAFSSPRDKSPYEQAVDQDVTNAMHAAVGLPVPWASVSPVPTALNSVSQILGLAQVPLDLHYWMTRSLSTGLPLTTILSISVFLIVRELVDWAVQHRTTPLALQLGPLFTGLMSFMLLLPQLMLLFRLEVQWGGPGGGVPTGLSRRKATHSERASARADARFDWKLRVALGLAIVIFSRFGPSVPPILRGSRPPPPESAEDLAMYRYTLNPLRSEYVLPALRIVEEVSQLHLVYRLGVFASRYRLTAFLALTTSLLDIVPRFIWNWHARPDVTLGEVVWLAGEAALCYAACRFPSVKQEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAG3</accession>
    <name>A0A2S5BAG3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAG3"/>
    <dbReference type="STRING" id="741276.A0A2S5BAG3"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="104"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="515"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="601"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="675" mass="72693" checksum="F51A4246F1BC2821" modified="2018-07-18" version="1">MTATGDASPATIAAAGEPRPASPHRDPTNALSPAGSVASSSGQNHAREGVGEDERDELEEDGDDAASSDARSRSVEPGASAPPSRRASDSGLFTSMAIPSTGKTQASFVHKVWGMLEDPALRQYIAWSEDGKSFLVFNPVDFARDVLPRFFKHSNFSSFLRQCNFYNWSKVNDALSHTNSFAQPGGAQSQAWEFRNPSFQRGRPDLLAKIKRKTAKSSSAPTPAVNSRRRTSVTSLASSTRANRPGSSSRPNDTIVDTPDDISDRDEAPTKGPNHRAGETRDGDLRGSDYNFPAARKPATTDDVLPYLAANGRAPKEEEGSPPQTQTRRPRSGPLNDEAPYFYTQAGPIRYSPGTRPYPLPGSSSYSSYRHSLAEETTTRHVRALEHQVRVMGEVLHQEQHEHATTRATSYSVLQSLIEAVAGLDKDGRYHAELQAAHRALHRFESAPSPPSALLSAFATQQHHSSISWPGASSSSNGYSMPNGYSVPAGYSSSLRPGSASQFYYNRVPAVESYTRTARPDSRPVMPSHSDLRPASSGSPFDPNNGQRSPPEVESLRHSVRNETAGSPTGGVGRGPEPNSVGLRKSYVVSAFPPSGCLAPIASAHSSGTNESHEVESDRNRGANAESQLKPRTLPPLSSLLNPIGPPSSHVWSDRPPGHESPAHSGERSPKRARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB10</accession>
    <name>A0A2S5BB10_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000031">
        <property type="protein sequence ID" value="POY73947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB10"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015658829" description="Protein CPL1-like domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="3">
        <location>
            <begin position="316"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="388" mass="40243" checksum="E02963EA7495A67E" modified="2018-07-18" version="1">MHAQQNMSAVFAVAALLVSIANAQPGRFPCGKSTPNQQVCDLLSHPTARRGVLVPIDSECVEAGSRTDKGVTSDSYGRRSAWARRGSRLSRSVFGGGTNLPNAAEQQNRLRAGSDAPVFCACASRCTSDLQCDFGSCTGSASSPGVCVGGLGDPCEGSDGPDDSLCAGNLGCQVDVTGGGDAGGEAARYVCGGAGADCSFSGNYESSSRPNHLACVSGAFASLLPPCSHHLTSPNPIAGWCNPSSLSCDTRSQSVMARVQSDQRVYRGVRGDDGAEDAAQHASRRKSIPLPDGSACPAGFSACPIPRKNSPSDYLFACFDFLSSETHCGGCHDVGAGFWQERQPGVDCTQLPGVASASCVNGQCQIVSCSDGHQYDRDLSVCVPMRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB69</accession>
    <name>A0A2S5BB69_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY73998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BB69"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="10">
        <location>
            <begin position="1669"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="829"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1173"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1222"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1819"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="829"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="887"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="913"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="948"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1278"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1827"/>
            <end position="1836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1982" mass="210013" checksum="04AC3DF042E40F95" modified="2018-07-18" version="1">MAGPPLPMRPGPSGIGFGPNSSSGSTSRPPQPYPDALRSGVATMAAGRIASPLSLPNRPQSVSGQAQAAPGYATPPAQRPFTPTPLSNHRLDPSSSTATSPHGSASHRTTPTQYGYATGTTSPRGIKGTGPPPPVASTSQTPGLAVPDNSHPDASPWAAIPPRLKPEQAVPTTQLIELGEGWTVRYRAWKAPAIFVSCTPPSDVDGRPSGDASSTRGRMDYDPWRAPLGSVSPFPAGTTAASATAKGKAPAKAEPGSGSDGQPPAKKARKASTTASTDAAGPSTSRPGNAFDELLAQEMGASTSSTGSTSHALGLSISDTGSLLGEVIRTPPIPSSSAADPAAKPMRLPAAVRKARAEAAAVASASSSGAANTTSQPTHPLQASTASTDTSSDQPAASGSRLRLDTLSDPDFLSTDPLQLALRYLDRRRVELASEGRDRLDLLWHVQRQPVAMGGRQDGPDSKSEAGEDDSDDSSHPPGDGDGRVLWVFSVVKGGEKDAEEEHADESTFLLDGMTFDGLTALSQGDFTHATLFPRLYAARSGASAQFLSPAKSTARSYPSALALSEKILTVPSAVDPTPSTSPLQGAYTVFRDAVASCILDELAMNPPDGRKCLRFHRAATFFADPSRLLADLIPPPTFRIEVKPPSVQRSALFVSTIVTEVALTPLPTRPPMGKTTLGPLAAGCRLLLAPSEIPAIYVKDVLDGDFSAAHLHDLRAEWADARRLAGLSNDGPEVDAYVVCRLQAKDGQTGIEVFWPRCLALESRCLFETGVSTAAVAPAGSDLDSTASTSPAMARLVDHDGVAQHVPPGLPESNDVWAWYKDETQRREDEKAEALRREQDERESAQRKEQGDATASDKPKHASSAPHPAAPINERTPMSLGTASTEAPSPAELLALPPGQGGAPPAELPLARPEESRNDRDPHQAMDIDFGLGFYPSPAEPAHQMLPGSSAPPSAPMSSIDAALSSFDWGDGTFGASSSAGPAALPDPSLPVHDHRYEDSMLLGLTDDDFSFFDATPVTGGLPGMAGSLAPGAVPTSALAVSEPHAFAPFVSTTVQHPATNTFDFDMLGIGSHQAVPFPMPHDETFIDSTLHVTSPASRALAVSHSAPSQPIDARAFGVPSPASTGSVTQSPPVIDYSPAICDAPPHSDPSVQFAYITFDEPITAIDDRYDRRHGKYGLPSPQSEDGSTGLHLVPAHGREKRRTRSWYEALCDPHVLRADQLSAKRSSQSKGGRMQRDAPTRGTSHARSWVQRRGAHSADARRSVDSEAGVSPDGWPMDEAEDSSDVDEADDGQVPPSDDSEADERASVSVRKTAIPSADDSEYTAHAAILAVCGEALSRIVTVASKQDLDHHAATGPRSTTYEMIYATFAEVIVYQRFLRRALLSSAVQRKPDPASSASSTSLGETKLLVASVSLGLGVSPLFADPTVLPSLVQESTPVLSLRAQDCILRAEPRAFNYWRAMGFEPLTARKNVAAFMLAEADEQHNAPVWARDWLTSMSSTYEGLRLGQHQSARMPASTHSAGIEDGLLLVPPGRLAGHGTDFELKSIFAAIFELAKTHQNIVVYVHASVADSVDQLGPLADLLQQLAKCRAASTGPSVNVLAVPVAVSSLEASRGPDPSTFASLAFSVFDQLQIAIERLRLPAPETFPTARPPPIAPLGPAVRLFQAPAMTLALPTERQTRFALSWPPSSFDVEDRHRFLHVCYAARPVEGAPGHEWLVISVVDEKGETWRVLPRYLRYPPAVTVDVHRARIIWNFTKAIVDSADVEWRILVCKLGEPGAVEIKAWESVLNEFAAQSKRPLHLSYASIDSSPPLALARAGEAQTRPSTTSSSIPEEGEYTLQPSVTGAPKGTDSSVFDSDPSFFSFTPSEPISLPSTSVVAPASTFLIHVPRLTNLEHAASTSFDELKRLQTTSAYGIHLLCSTASKSSLYDDNVEAYLADVRRNFVELAGLGKARWGTSGRMAWHIEAARDSLLLSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB80</accession>
    <name>A0A2S5BB80_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2835</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB80"/>
    <dbReference type="STRING" id="741276.A0A2S5BB80"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="11">
        <location>
            <begin position="155"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="352"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="562" mass="61835" checksum="8F78FAE32C3B7FBE" modified="2018-07-18" version="1">MQQLAGRSRFQLNTATQVPAASRNGGRVTRRGAELFLGKSTFHAVGLNAYWLGLDENVDPSPSFPAKARVLEAFAVAAAMGATMVRSQTLGISYGTSLSIENALNVFKPDGDPAWDALDFAVFAARSYGLKLILPLADHGIPTFLRWRNLSANDYSPFYDLSSQVYADFELYIRTLLNHTSPYTNLTLASDPTVLAFETGNELGGWTGSHYAPPVAWTRSIAQLLKQLSPDALVISGTYGVKQAELSIAEIDLVSDHFYPLSTRRLAHSAKAAATSRLDPKAFLVGEYDWTNKAYESWRFAWFILLLPVAIALVLLFITPSRWWPRTTTLRRLLTCGQRSRRRPAWARRVGELPSADGRTSPTVPLDSPNKDFSTLSDRLPILDPDSSYPPPRPDRQPGHGDSSSILDRPLTIKRWHLAPIPFLVFLPVLIPLLITYLPSAIGPFLSRLAVDQSPSDGSPRVAGDLWWSLFGRNDACTAYVQHNDGYTLHYPAFSNGSAISGAFTSDGSGARVLDLVRHAWGVRGETPFWLSDPSSSISWDTLPTVPCPQTPLRWPNGSAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBC1</accession>
    <name>A0A2S5BBC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBC1"/>
    <dbReference type="STRING" id="741276.A0A2S5BBC1"/>
    <dbReference type="OrthoDB" id="2529313at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015459576" evidence="2">
        <location>
            <begin position="26"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="296" mass="30515" checksum="1AF03C89B82A5112" modified="2018-07-18" version="1">MLSSFGASLCLLLAMVVARASFTGAIVITEPSSPTFWSNATGAVNTMVWSLLPATYPPPKTQYFDIYLRNAAPGMYSPGINISLATRIDSQMGTSINLTDISRFRAGGGYQLFLSDPTDASIVYCGSDVFAVVSPTLLSSPVSSDTSRSSALVPSLSTAESTAPPSPTSAVSSSPPASHSTTIVSASETQASSTRASSTSQQQLQNSSATSGAASIVSTTETITTTIVLTQSTTVTRSSAFHSSRRPPHSIMPAIAPGSPQDQGFNLTGAAAARTTFPRLSLALTLLSAVSALLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBE1</accession>
    <name>A0A2S5BBE1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBE1"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30833" checksum="20CB3DD65974F28B" modified="2018-07-18" version="1">MSSPSDETFPHNYLSTSPAHGVPGQHFLYAAPLRSPSPILLDLPIPAPKSRERYAGYVWNASVLLADKIAGGEIAVEGKTVLELGCGLGLPGIVAARTGAKQVLLSDYDDPEALSDTQAAVEEALPPSLSQRCIVVGHSWGTATNPLLEIAPHVDLILIADCVWERALHIKLITSLRALLYANPQATVHFASGFHTGRKAVADFLTQAAAAGVVPSPPNDWIELSVEGECRPWDWSRCGRAELAKLGGKDKNDLSSQTGRAFQTEERQEERNRWTLYGTLRLRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBL6</accession>
    <name>A0A2S5BBL6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBL6"/>
    <dbReference type="STRING" id="741276.A0A2S5BBL6"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="10">
        <location>
            <begin position="374"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="577" mass="63364" checksum="F5C3C8D40DD0BB92" modified="2018-07-18" version="1">MDASPHVTFKILPPTAFSFGLPLFALAVLLQPAIPAHYSRPLRFALAYPAVHAAYYAPYTYRHEPVEFSIPANFRWGIFAPYAILLALYWAFMTEKDRRVELAWVGFDGEKREELQRTVEAEEKVEEADEGEAGKRRAKLEATAQVVAPTPVRPDTAAKLAAVLPAATANASPVVVAQPGYLPTPSPTPPFEDINPPSVSSAAPPPADLDMVSASSTSTLGTAQRLHPLHILLSALHLLTSMRGIGYVFGPPMKHLPTPPRSERQFATGAIVTFFSASAISTACVALQVLDRDGQLPDFLATVIPCLPPSAAVFFSALTSRICIGLSLWVQMKIGFSGLAVGYWLLHHLTNYALDTVPFFKHVTWRSKFDTREYPPLFNRPFSGMGDGGCSRFWSAKWHFLFRAVFTGTLYNPSSKLAKKLGIPKRAAALLGAVLVFAGSAWMHWQALVSARHGTEPTAAGLAYLSSHSIPFSAGYSSPWSDLTTIERHGTWIFFLLQPVAIIFEQLFTLLTKKRIGGWAGKVWTVAWIVLAGEAIIGRSWLALGLVHGIPPVDRWGWQRWVMPTYEMAPMPAFMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBM5</accession>
    <name>A0A2S5BBM5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL24-related N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBM5"/>
    <dbReference type="STRING" id="741276.A0A2S5BBM5"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="149" mass="16603" checksum="34BCDDF9A3EA6FFE" modified="2018-07-18" version="1">MKVEFCNFSGYKIYPGQGRLFVRTDSKIFRFASSKEESLFLQRKNPRKIAWTVVYRRVNKKGISEEQAKKRSRKTVKANRGIIGADLAAIQAKRQQKPEVRAAQRAAALAAGKEAKKDRQAKKASSGPKPAQQKLSRTQVGKGAARGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCK0</accession>
    <name>A0A2S5BCK0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCK0"/>
    <dbReference type="STRING" id="741276.A0A2S5BCK0"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="162"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="734"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="321"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="346"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="409"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="892" mass="96096" checksum="47CA3684E5E68F2D" modified="2018-07-18" version="1">MDAIKATSVASVHLVRRHGSLTDAGSPLARPTNGSLHLTTHHAIFEASEPAADKGLDGLPSSVAGSQEKPPTLAREIPLSTLHAVTRSPPSLTGEPAPIVLRTRLYETFELAFSSLADADNVWDTLKGLCAAFSAGGLENQYAFFCKDRNSAQDGKGKGKAGWDIYDPAAEFARMGLGTRSKAWRVTSLNADFQFCPSYPAEIVVPAKISDTTLSYAVKYRSKSRIPGLVYLHWANLGSITRSSQPMVGITQNARSIQDEKLVEAIFASHGQHSHKLSPSPSNDGSPSSSTVGLNSPDFVYGSTATNVIIDARPTKNAYANSVKGAGTENMSFYKNCRKEYLGIDNIHVMRASLNGIFDALAEADVTGHLDRSALRRTHWLSHLTNILEGVLIVVRTIHLSNSHVLVHCSDGWDRTSQLSALPQICLDPYFRTARGLAVLIEKDWISYGHRFADRSGHLCDDRVEFAQKLGTDASTQQAFIASVTRQFASSSHAFKETCPVFQQFLDCVYQLQRQYPERFEWNETLLRHLVRETYEASTGSFLFNSEKDRAAFGARTRTSSVWETVFDADDAGSLTLKAAFRNERYNPSLDDPTSKAIDADLGVLLFDPQDVKWWYELFGRSDDEMNAKPFAQEAVAGLLASPEPAAIPTEHKVVETAADDPVTNGVVAKTASLVVSAGTAPLAAVSSAGSASSLPPARSASPASGTQPDRLASVQKLGWSAWKSVRKFGEDAARQLKEQQQQAAAARATAEAEQAANGSGSQAPLASDDWATRATSFGGGVWSKLSSGNPWLAEGQEPQTTPGRRDEARTSTSSRPSQELAHLPATTERANPIRPPVRHPSSTLSSNPWETVTREEAIPPSHSLPPPVGLVETGAGTAPSRPLDPLGVGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCR1</accession>
    <name>A0A2S5BCR1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_2326</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCR1"/>
    <dbReference type="STRING" id="741276.A0A2S5BCR1"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY74565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="72" mass="8477" checksum="BE01C46F49B02179" modified="2018-07-18" version="1">MNNPYEEEQVVIISRILGRVEKMNESMLELNRSVEQVNNYNVSIAEVVELWSTYMRNVSWNLQAQNELHPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD13</accession>
    <name>A0A2S5BD13_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD13"/>
    <dbReference type="STRING" id="741276.A0A2S5BD13"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="259"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="668"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="706" mass="78848" checksum="81A8212F46B61B49" modified="2018-07-18" version="1">MAGSNFNIEKLTKAMKHHKLEGETVHPLASLQPDELRIAARVVKAANPGKVCLFRRILLIEPPKSGVVPVLEAEIAGEPLPQGPIRRSQALFYFQGETEFMEAIVDITHERMLGQRHLEGEHGPGDDEEVLEIAKASLESALVKKELERLQLPEGSEVIAEPWPYGSDDTETPTRMSQVWFFLNYKDKKDHPSANFYAHPLDFSCAVEIATMEVVRIDRLPTDLEMTNESQTARFVPNPDCEYAPDLLPGGVRQDLKPLHISQPEGVSFRIAPDGETITWQKWSFRCCFDVREGMILRNVCYDGRPLFYRMALSEMTVPYGDPRSPLHRKSAFDLGECGAGQTANNLQLGCDCLGVIAYLDGLSCSHDGEPVVIPNAICIHEQDAGLGWKHTNIRTGRADVTRARELVLQLIVTVGNYEYCLYWIFDTAANLHYEIRATGIMSVTPADPSVDLSTLGYGNVVAEGVFAPHHQHVFNLRIDPAIDSYRSSAVTYEDTHAMPRDPATNPCGVGFVCKSTQVQNESAFNLEHLTNRYVKMINPNKRNKFTKKPIGYKISAPPTQLGLADPTSMHYIRGEFTDHHVHVTKYHDAELWGSGEHLWQSRGGRGGCRTWASRGREMEDDAVLWFTLGFTHITRPEDWPVMPSETFRMHFKPVGFFDENPALDVPPSTQAVNKSVLANGSARPHERRDSDSSNSSAGASKCCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDB7</accession>
    <name>A0A2S5BDB7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDB7"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48512" checksum="7AD43161A8E15DD3" modified="2018-07-18" version="1">MSPAQLSSLPHELKVKIADECYAADQRIDELFEDLERRGGLAFESRESTSAKQRRKAYPSAISALYGASKEWNGIVVGYRFEMAKPLFQLALARRYGHLIHRASVSALASAENLASFVGGLGYCPNLHSLVVKDLQVSMDRLLAFAGKLATDEALASLADACRQLTSLALGNARSADTNRLLASTTRLQRLSLAFTSIADLHGLWTMLKSVPGLTALDLALPAPATAHPACLATLANTAPQTLPPITELKVELRGGATGLAKFLSLFEATLQDLSLKAGNFAGFAVGGGSDLFTSQSALPRLSRLELAGESAGLGRILQRLEPERLPSLRRLCIFPNHASRTVDLFPFIELAVLQHVDLSRVEYYTLMSRPKTHHSSVLFDELGIEYVSSPCGLNLAYLKAHDKVQALSAEPEGSELRAGMLANIDKSLDHIVRARNLAALHNDTASYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDD3</accession>
    <name>A0A2S5BDD3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Xaa-Pro aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDD3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDD3"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="9">
        <location>
            <begin position="50"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="8">
        <location>
            <begin position="397"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="10">
        <location>
            <begin position="626"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="693" mass="77092" checksum="4529FD12A4E1081E" modified="2018-07-18" version="1">MLSRITSRLPSNLPPLRPSSLLSSTRSKAAPFARSSSSPSDAAMFDSSKRLAALRSEMQRHNLQAYIIDSGDAHSNEYTAECDDRRAWISGFTGSAGTAIVLAPGQSDDGKAFLWTDGRYHQQASKQLNEQWSLMKHGVPDVPSWTEWLTTPSHSASFLPAGSRIGLDPALITVADYTKLAPPLETAKVELVPIRENLVDLAWDAAEPGTKPARPRNEVFRLEDKYAGQSAKDKIAKVREELQKKDVFGGDKKAEAVGGEEEKRCWGLVLTQLDEIAWLLNLRGSDIPYNPVFFSWLVLPTASASKPTLFVDLDQVPQKTYEYLANELDVLIEPYEGLIPFLDGIQQLLTPQDLVVLPSATNLSCALALSLPRCVTSTRGPISLLKARKNETEVQGFRNCHVRDGVALVRYFSWLERELNKGEKEWREYEAAEQLEEYRKQLDLFRGLSFNTISSTGANGSVIHYAPAANGESAVIDKNKIYLCDSGAQFLDGTTDVTRTLHFATPTAFEKRAYTRVLQGHIAIDEAVFPSTTTGYMLDPWARKALWKDGLDYRHGTGHGVGSYLNVHEGPMGIGSRVAYNDVKLEPTMVLSNEPGYYQDGEFGIRIESLVVVKNQQTPHEFGGVKYFGMEHLTMCPIATNLVEPSLMSMDELEWLNRYNAEVREKVAPLLRETGDEVAMEWLERSTQPISLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDF4</accession>
    <name>A0A2S5BDF4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDF4"/>
    <dbReference type="STRING" id="741276.A0A2S5BDF4"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="167" mass="18339" checksum="2AC11AEEBEC1417B" modified="2018-07-18" version="1">MADVSNPEIKEAYEKVRNDKDDTAWLLLDYASDKSDVLSLTETGTGASLPIPPPRSALLSLTNSGECTQGLDELKTKFQDGRASFAYIRVKYSNDAESVREKFVLITWIGPDVRVMRKAKLSVHATDVKKVLAAYSIDVAASSQEDLAEEPIVKRLRQAGGASYDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDM5</accession>
    <name>A0A2S5BDM5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDM5"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="424" mass="45550" checksum="16CAFFD3E869D64E" modified="2018-07-18" version="1">MPRSSASPLARPSPSSAAAATPRHQQPASPSRQPRARMTAHSSVPGIINLPQPKAFHQHQSSSRSTSPARTPFRHSSHPPQPEPTQQDKPADVVAGSRTTQVKRRNREKRGDSPLKHVADQAEPSPGYPPVADAILANDLAGTESPSKPARKRRGGRAARQPSPPMPPTADAHLMAPPLPAHSRSLPNLDARTTYTSLPVEDEWDMPASASAAGGAARGNADAPKESLSWQQELLRNGSVGLHSSSQPSRHGNSGSPISRPRSRGHVAKDQQRKQRPALTTSHSESFVASSSTLNWQQELLLRTDEVQLVQQVTVTAGPNATPARQRRNQIKDSITFGLANLDLAETAFDDSIGSPVAPASSRRQQKRTSHTPQVVVDDQLVATPTKSVEPRYAGPTFHNSPAPSALPMPSFMLRRQAETVAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDP1</accession>
    <name>A0A2S5BDP1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDP1"/>
    <dbReference type="STRING" id="741276.A0A2S5BDP1"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="456" mass="50200" checksum="17B24BD2BC774C50" modified="2018-07-18" version="1">MPSSRASARRNAGLGTQRVLTVRETLEKIIPERQALLKEIKTQHGSKTLGNVTVDQVVGGGRGIKFMLWDPSVLDAEEGIRFWGRSIPECQRDLPTAVGGKEILPEAMFWYLLTGKVPSAEETKQFQEELVGRSELPAHVEKVLDALPKTLHPMTHFVIGVAALNHDSKFAAQYKAGMKKSEYWVPALEDSLDCVAKSFTIAARIYNNLYRNGHDASVPAIDKSKDLSFNFANQIGFGESEGFVELIRLYNSLHTDHEGGNVSAHTTHLVGSALSDPFLSYSAALGGLAGPLHGLANQEVLRFILGMQKELGDSASDEQVVDFIWKTLNKGQVIPGYGHAVLRKPDPRFMALQQFGVKHPETANDPVFKYVDQLYRVAPGVLTEHGKTKNPYPNVDSASGSLLYHYGLKQFDFYTVTFGTSRAMGGLAQLVWDRALGLPIERPKSLSMEAILKAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE15</accession>
    <name>A0A2S5BE15_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE15"/>
    <dbReference type="OrthoDB" id="10523672at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="182" mass="18886" checksum="B146663D31B66295" modified="2018-07-18" version="1">MLPIPRNRQDRWLFLSARSQAGSRTMPPTAAARYTFPSRLRLGASVLLLSLCLSVPVLNAQELTTYTDTGAQIVTTTIAPTVYTTEGQVFTWTATTPSTVTPVTFSTGSIMDMNDYIRSKSAATAISLSAPSQTASLRGGHPNALAVDHSSAAAPRGGAGGVGTIGTALALGVVLSTTAIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE33</accession>
    <name>A0A2S5BE33_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division control protein 73 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE33"/>
    <dbReference type="STRING" id="741276.A0A2S5BE33"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000004">
        <property type="entry name" value="Potential RNA Pol II elongation accessory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="259"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="444" mass="48772" checksum="927A8115E8E74E4D" modified="2018-07-18" version="1">MSLQDPLLLLRQALSSGQAVSLRSSAGAEVFNLKDADEIVFGHGDKKQAFPKTTATRYLSDPKASVEDPAAPTYDLATLLLGYNERNAPLGEYLKKANEAGVPFISTTDRRAVCNWLGGEGDVDGPTGRIRPLPAGAKRGADDEGAATAGTSAGGAAPPTKKARYVPDRDDQEKVKRMLGVIDGPAYGFLVGPNEPKVERSGGAYHTRETVLRGERINNFESVRALVAPRLKQMKEDLGKRQPAQPVAPIAAKQQKKKQLNPIIMISPSSTALITMHNVKQLLEEARFVPSDDARREAAGASTAYVAEDVIQINHARATGTVGGAGNETRNARYFVVDSVEALSKFGGAGKLDEAWDRVVCVMTTGQEWQFKPYKWKEPKELFHNVKGVYPQWTTDPPNAKIRSWNVNELRIDRTKRHIDKSTVADFWRQLEGWIQNNKPWLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE65</accession>
    <name>A0A2S5BE65_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE65"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="325" mass="36252" checksum="F8888A969D1EA0EB" modified="2018-07-18" version="1">MIDREKPREAIRFGATCRRLHALVLPIAFKGLTLWPEEKKIWDGGFIGCSLPWLADYLFQRGHLVKTLSLPLLNELNVLERTMRLCIARCTAYRNLVLSVLDSRDGRHTRNTGPLNWLFSAIEHRAPFQLESLVIKASKQLEPHIVGYASLIARSSNLRHLVVSGESKADSAPFEVSTLDLTIASPVASRLRHFLAVFSAHLHTLNVNFIDDLQDDLPAPPVYFPALDKLRLYGADSIRVLQQMTHPDTPVVSLCFDGRDPAGLAIFEAFYRSQSNQTIKSCALICGSSPSDDPQVNASLRRLDEFRRRVMQGKGTSLAASPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEW9</accession>
    <name>A0A2S5BEW9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEW9"/>
    <dbReference type="STRING" id="741276.A0A2S5BEW9"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="43848" checksum="1D2661F3044379E3" modified="2018-07-18" version="1">MAGGAVSTGVAAAGPKLTKRERIYAFALVASLFFAWGLSYSFIDVLNKKAQTFFKITKLMSTMLQVAYFGAYLVMSIPASMFATRFGYRKGVLLGLALYVVGALGFWPSAHYERYAGFVVCAFVIASGLATLETMANSYASVLGSPEGAAFRLNMAQSFNGLATFVGPQIAAHTFFGSKNENSLGAVQYVYLAVACLGIALFALFCFAKLPEITEASIEQEQEASGLVDERPLWKRKHTVFGFATQFCYRIVSTPLLKFFSPALVLVGYGIMTTVFTLVAALTGGKAGLGALFLVFFGESVIYPTVFTLATSNLGRHTKRGAGLLCMGVAGGALFPPLQDIINAVAFSTVIAYGIGMFFYNRRMQKTLGDAAVFNTATLPATEAFDEKDSASIEKVDIVDAQNAHAIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF87</accession>
    <name>A0A2S5BF87_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF87"/>
    <dbReference type="STRING" id="741276.A0A2S5BF87"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="3"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="813"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="860" mass="93509" checksum="D2B9571E8043E6F9" modified="2018-07-18" version="1">MSNLLALGPKLTTPLPRLSDDLYRALSEASLETHPNELKPDLEAWHHLRLACFPAGLAALPGPDAVRHLALQVLPPRRSSQGDEADGNAIPTKTATMLTITFPWSPLAPPSLPSPLAPGTISPATTSADASLASERLAVLYSLAYVHAALGASTRRADEQGIRAALAAFQNAAGTLQVLASEIGKLESRKGAAVPVAADGGGEAQGLRPDLRKEVVACLEVLCLAQAQEVAWQKAVMDRLKNGTVAKVAMHAAQLYQQARDQAESIRSEADVASFAFADDLSRYLAFKHAHFAAVAHYRRSLDDLGANRYGDELGRLRLCDQVLKEVVASKGKRGVPDAVVKDLKSLQGMITENLARANKDNDLIYLATPTASTLLPPIVPFPLAKPLIAAELADPLGYLNQIQRPGWLRALVPRRTRDALELWEDRKMVWYGEVVDRGAKKLETEANSCLAALNLPAALEAVQQPIGVPATLVERSEHIRTQGGLAKLETMMKDVRRVATVNRRLVEESHELLAHEADLDSTHRQTYGTRSWTRDPSAEVSAPLAQRADQLEAVLNAAGESDGLVRAKFGEWEETISVLDQGQAALEDAIPNSSTGSTSTARSPELQKASRQLRASLENLADLCSERDKLIHAARTRLEQASIRTRLERDSQRRERTLHEADEGNDLAALEDLLTDELAKVGAPFEQDLQRSRARQEDLLDQIKQQNGAFVAAREAKNESHEREEAIRLYETAAAKYDEMLNNLHEGLKFYADLSRLLGELLDAVKAHVHAREAQAAQMDAQLRQPPVQTVELAKSTAPELDQDKLAPPVPVTAAAASPRRTSPRSPAKRKTEKATRAPVAEPSPASSGWDPSQGIRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFB8</accession>
    <name>A0A2S5BFB8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bet v I/Major latex protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFB8"/>
    <dbReference type="OrthoDB" id="10255646at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332">
        <property type="entry name" value="BLL4707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332:SF7">
        <property type="entry name" value="SRPBCC FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18723" checksum="ED90DCFFA5B9ED42" modified="2018-07-18" version="1">MSSPATGNFVSVSAVIRAPLTSVWHLIKLQDFAKWWSALEKSAPAEKGVSGEADVYSWTFKASQVECWSARNRETDLHPTHEQDGTSLLVKQEEHSALRHSISYSVVTSEQPLSYSSVISTISLAAVTTGELAGSTFVTWTGQFSSDADAGVVEDAKYKREEALADLAKAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFG8</accession>
    <name>A0A2S5BFG8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFG8"/>
    <dbReference type="STRING" id="741276.A0A2S5BFG8"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="54944" checksum="7C04FF6C26E2C7EC" modified="2018-07-18" version="1">MSSRRRRSSAATADALGLVESTSYARLTALFSHALLTVALLVWINVSSPFVLSSVLAEELPAHAIGSATSRLLLADELTALSLYLPVGLASDSSKWGLKRSAVLGYGIVAGALCAYVRAPTLEWLIAARILFAMGGSTLVTTMSALLLQMSAIPDEVVYGSTSPSLIPPQETFAETATETSQLLSRRGGAQTAAKKLRKSSRSAGILAFASGLGAVVAVCGFLRLPLLFARLDASSDPDSPDALRYGLRATFHLLAVVALVQAVFLAFALPAAEAESFEPDEALPVAVALRQAAAKLVEGFRLGGKDGNIALGFASSFASRAQTTVTNAFLPLLIERYFSKYHLCDASLDQSLPQNGRQSCRKAYLLASALTGVVQLLSLVLSPLVGFIASSESLSRRTRHPQACLLAIACMIGATAFLGLSRLPHDGDPRSPLTWISASGIGVAQAAGVVLSLALVTTGRGIISAEQDGREVAGALSGAYSLSGGLGILIVGGAAGFGFDRWAGAPFALMVLVHVAIAAGSALLYRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFG9</accession>
    <name>A0A2S5BFG9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BFG9"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="1224"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="696"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1840" mass="199252" checksum="48A538B81418BF51" modified="2018-07-18" version="1">MNGGQPAREPGLPSGTFFHPFRIPVPKTNRQPPPSAAPSSIRAALPTASTSAYKPFGEPVKAIRDEARARPVQTAGIRDDRQAFSLPLPLPPPQAPPAAGPSHAPGGDMRRAALVSGSVRVGGLPSEEAARAWRNGPGVDSLSKPVHRPLRSSADEVLPATMTSVPPPPPKPTSSSQSSSHAGQAHVGPSQPGASGSGAAPSASGSDASTPVVYKLPTPYKGRNYAEKRPKAPASSTGSFAPFSAIIRGVPFDPSAIAVGSTTEARPSKRPRVASPAIEVVAPKSVPPSNASESSTSAQSSPSAASGSKALRSTAPVSGNLTVSASSPDAARSLATILAAVDPAHRSTADRPRSSNRSALAPPPASRVSARIEGVPAPAPAIPPATDPMPAVSTDSDERSEAAALGSSLSGALRKTQAATEATTKPVVKETKVAAPVKKQKSFELEVPIYVKPKATEKVGLKQSARTRSAAAKPPPFDVTRTEPAADRPRAMGKGKERMAVEHDGHASDGSSSSSLTPIESSASSSDLTPLNSSDDEAPQSGPRVPQKRVGPPKWARLPARPPKQPRASRGRISYAEPTDEEFLLAVPVAQGAALKRSARDSQAVDDQNSDDAVSRGLMTGDWTSRPAKGPNDRSQAEAKPSAETAKGLNGSAQTDVTRALPGMSSAEGSSSKQGPSYGRSTPSARFLLASPAATPASAALKGRRRRPSNVTNDQTRSARQAASELIALGEQIADDGSAAPLRPKAADVNGNMAVSIDWLAADVVDEARSGKHGFHLQAKSCAAWVSTLPAPSEGPPVSRCHECIAKRSGFICCFQGVRSFPLDAEGRVLPYPVFRDFEGDDEKATLPTVFNGPLTAERGALLRSAIAEHSQASLKAEVDHAERPESVRLPKQLGTTYTCDGCATSILFASWMCTTCAREFCRECRDELETLPIEEIRQRAGSRRLFTPGPRGDIGGTNVYTVDKLTRCVSTDRHGLEQWIPIVRIDRVLLRQTVANMTWWKVNRPLSVPGPLTQELLDYHFVQPDAMEVSLKYLKVPGRYLPPMLGSGPDLALQATRSGMTQSHDVLQTDRTTLPSGFHSLDKAALPVQLHSFAAGLASSAQTGSSRQLRRPGAPPPLSKALSPLDLFSALWQRGCPVVVDLAPEHYPSLPWDPDFFVERFGAERCRIGSARVKQTLRDGTTVDCERNATVGDFFASFGKARDHSDIEKIKDWPSARDFKVEYPDLWEDFMSILPAGCVTRRDGALDFAAHMPAAANPPDLGPKGYFSQISDAMPGGAGSTKLHTVNIMLWSSDAPDGSPGVAAWDLFRAEDAELIRDFLYEQIALQEGLQDAAEARRYHDDPIHAQRFYLDAGLLNALHRSKGVRPYRILQRPGQAVFIPAAVAHQVCNLADCIKVATDFVSIENLERCSRVTSQFRKQTKDKTLWRTDVLQLKSMLLWAWYRRVSEPPRPRAIGDGLYSGNNCIGKAHFGPELDATRCHSQNVCIELQKPVRPQQWDYAKDWKPEQSVNMTYYRPATARDTPHYSDRKHEITKPWVRLHTDNYLIPHVVYEPLPADSVWSPAEHAILQESFWPENFGHSMGDDFFSAFHLAQSFGIWDRSDIQLIMHPACWDRGRVCFRNLYTGMSRLGTNFSSENMLPPFLGELRATAGLERSPRPRHQRITVFLKHGRRTFLNYGSLVEHLRRRFEVEVDLLDPAELSIGEQLAYLKDTTVLITPCGGLSYSGLFLPKGTGLIVADYWHLEANVYNGTSPMELQVFAMNNGVTAYSFPLEARIWNMGADIQMDDSAVPDWEAPGEWIHWKNWANVTIDLERMSSYVYSALLSAEVSQGWQHSFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG80</accession>
    <name>A0A2S5BG80_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG80"/>
    <dbReference type="STRING" id="741276.A0A2S5BG80"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="61"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="304"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42454" checksum="624C1FDB5D98A280" modified="2018-07-18" version="1">MSTIVDKIKEIENERTRRVASLLPVLSATSYHLGQLKAKLAKLKRELLTPTSGGGGGGLGFDVARTGFPSVGKSSLMSGLTGTESVAAAYEFTTLTTVPGTLTVHGAPIQILDLPGIIEGAKDGKGRGRQVIAVARTCNLICIVLDVLKPLGDKAIIENELEGFGIRLNKQPPNISVKKKDKGGIAISTTVPLTKITQEEIKAVMGEYRMANADVHIRCDPTLDEFIDVIEGGRVYIPCLYVLNKIASPAEQKSRATLTYLLSTDAISIEELDLLYRIPDAVPISVKEWLNIDELIDTMWAKLDLVRIYTKPRGVKTPDYTAPVVLKRGKCTIEDFADALHKSIKDQLKYAVVWGTSAKHNRGQKVGLTHELQDEDGESARSALMLIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG98</accession>
    <name>A0A2S5BG98_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG98"/>
    <dbReference type="STRING" id="741276.A0A2S5BG98"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05262">
        <property type="entry name" value="SDR_a7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF9">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="301" mass="31719" checksum="51F176BC763F4CD9" modified="2018-07-18" version="1">MLVFVTGAAGFVGTHVVKDLLANGHQVLGLARSEENAAKLRDLGAEVHYGSLDELESLSAGAAKADGVIHLAFKHDWANFVASCELDQRVITALAEPLLGTGKPLVTTSGTLMVKKKPGDDADTPATEETQLPPVQGHPLRRITETTTIGLAPRGVRASVVRLCPTVHGVGDRGIIPMIAGKARENGFVAYLGNSDGVLPGIHVKDAAALFRLAVESAPAGSILHAAAEERVPFKQVLETVAEKVGVPLKQVGPEEVGQLGILAMFLSANNPTSSKKTREVLGWSPREVGLVEDVHTNYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGF9</accession>
    <name>A0A2S5BGF9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0938</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGF9"/>
    <dbReference type="STRING" id="741276.A0A2S5BGF9"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="342"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="729"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="736"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="801" mass="83517" checksum="ED525CFFB6C45A70" modified="2018-07-18" version="1">MELALAPTLASSAAVPTRPNRATQRSVPAFLNKLYSMVSDTSTDDLIRWSEDGESFFVPSADRFGKELLPRFFKHSNFGSFVRQLNMYGFHKVPHLQQGVLKRDQSEDADVRESGLDPSPPLPSASRADRCCAPARAPAVVEFSNPHFVRGQPDLLCMIKRQKAGKGETAAAAAVAAAAGASSGITGPDGRASPSTTSLNIATLLSDLAAIRKHQTAISADLKDLQARNHALWQEALQSREKHKKQEETINKILRFLAGVFGGQVLDAGQAGSQPQVGADDSESPSASGAAAGSSANGIAGPSSARTGAGKSGRSGTGGGVVLMPKSRLLLEDVKGRQQQRRAALREWDGDDDVKIAEQPDEDYDEDEPGHGAGGGGGDDDDDDEIEEIPLLHAAEDEEDMPIISSALITSGPTSAPGALTRAPSNSSFPATSSSSRFSAIPSPADTTKPKDSPGPSSGLIDPSQYNMPPEAVRALLSAAGSNPQALQDFLRTSGANVTSSGTTPVASTSYGSSASGLPATSSALLPYHHQPLYNPTPSPLDFSFSSSLAPATTALTTAAAAMPSPISFESALAENNDVLSSVLSEKADIDQRTAALENQITKLLDNLPDDAREQVENEAANGESSNWAGIDWDNYTNDDGGVDFDKMLAQLSEICGSGFRVSARTMIASNNDAPIDYSELLSNNALDPSLTSTAASSAPTPSAGLIDPSLYNLGRESIGAQPAYEVTSPAGTDLASPASSVNSPASITSTKRPSASTTSRGRKRKSDVMGSETTPAEPPAVTTPGEESAGTRRSTRRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGN5</accession>
    <name>A0A2S5BGN5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1015</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGN5"/>
    <dbReference type="STRING" id="741276.A0A2S5BGN5"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="737"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="855" mass="92107" checksum="16C60ABA11807A99" modified="2018-07-18" version="1">MSAHYNLKALIKAIRATKTIADERVLITKESAAIRSAFKEEDTHARHNNVAKLLYIHMLGYPAHFGQIECLKLVASPKFTDKRLGYLGIMLLLDENQEVLTLVTNSLKNDMNHASASTVSLALCTFANIASEEMSRDLVTEIERCLGSGNAYIRKKAALAALRSLYKDPDLVEHFENRAMSLLGDRNHGVLLTGITLVTEMVRLVGSDPFRSAVPLLVRHLKSLVTTNYSPEHDVSGITDPFLQVKILRLLRLLGKGDVEASEAMNDILAQVATNTESAKNVGNSILYETVLTILDIEADSGLRVMAINILGKFLGNRDNNIRYVALNTLLKVVSIDTNAVQRHRAIILDCLRDGDISIRRRALELSYALVNEQNVRVLTRELLAFLEVADNEFKLGMTSQVCSAAERFAPNRRWHIDTVLRVLKLAGNYVKEEVLASFIRLVTYTPDLQSYTVYKLYTALKGDVSQEGLTLAGVWMIGEYGDVLLQGGMTAGPGEEAEDDGAATTSEAVSEKAVLDLLEKILVSPYTNTTIRQFVLTALAKLSTRFSQADSLARISKVMHGFDASVELELQQRAIEFGKLLTLDSIRGGVLERMPPPELKPTVMGTVSEKRPVGSLRRDKDALLDLMGDEGTGAGPAGGAAAAAVPAQSAQDLLADIFGSGDAAPAAAPAAPSQKQSDPVNDIMSLFGSASISPQPTGPAPSSASPSNDLFSAMSATPAAPVAAAAAAPTPAPVQTGPQALEAYNRNGLRITLTPVRDSNNRMVVNVLAKFTSTQPVSSVNFQAAVPKTQKLQILAMSKTDVAPGSTETQQLRVMVPAAGSLVRLRLRIAYTAAGQPVQDQTDFAFPAELMAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH26</accession>
    <name>A0A2S5BH26_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH26"/>
    <dbReference type="STRING" id="741276.A0A2S5BH26"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20351" checksum="142EC1171B16AF91" modified="2018-07-18" version="1" fragment="single">AYNASGEGLDGARLVGTFPLLPFRSSLRGPAPQPADPSQPDIIDEALTLFRANALFRNFEIKSPADRALIYLILFIGDCLGRIAQARTWGPQDALKNLSTHALSQFALPGEPGFPLNQVFSGPAAGDRVGSDALRGYLTHARQETVQRLIESYVYSPKDLSTEGGKKPSKWWMSFSRRAFMNKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHC5</accession>
    <name>A0A2S5BHC5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neuroguidin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHC5"/>
    <dbReference type="STRING" id="741276.A0A2S5BHC5"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41960" checksum="A2B48905B7350033" modified="2018-07-18" version="1">MARSVSPEARATRAAASDIPEQDLVSLRTHLNDIKQGISAATESAQAWKQRRTATDDLDYSSGISLLSLKNHLLLSYMQHLVALFSLKLSSESLTGSEQAKGVVAHLVKLRVVLEKIAPLEQKLKYQIEKLVRKADQFDDQGAQNEEEVLNDPLAFRPNPSNLVLDRTVSEDEDEEEAEQRAGIYRPPRLAAMPYVEAPAKGKKKREAAQQNSHLLSDMSHSMLSGTPYAEATSGLSVSYDPSLKSGAKARLDKILEYETSNFRRLGKSKKDERDRRRMEEEVAFGGLGAGKGGKRRLGGFGAEFDDLLGHGADGTTSRKGEKRKAAAYEQMAGFKKPKVARPERDFDGRSSSGISGDGAGGGQKRTKSKFDKAVKRANAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHH6</accession>
    <name>A0A2S5BHH6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polysaccharide lyase 14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHH6"/>
    <dbReference type="OrthoDB" id="2395160at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="1">
        <location>
            <begin position="73"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="353" mass="36476" checksum="292A66C190765B2B" modified="2018-07-18" version="1">MSSLSSQLTLPHTLASGPASLAAAFGLSSFVYAPSPPASASNATAFLTQSWHAGSVSGAANLALSSDPFGTGNTTVAVHYPKGTRDGAQFTIPAFHRAQAPVQTAVLTYEVAFDPTFDWVKGGKLPGLYGAAPNATAICTGGNHEPDCFSARLMWRNRGIGEVYAYVPSYQGFCQQSDVLCGDEYGTSLSRGSFSFARGGWTRITQLVSLNTPGFANGVVVLYANDTLALAQTGIIFRTRQNVTLTSVLFSTFFGGSSDSYNSDGGTSYFRNFGVWYGPSSSNTTGPAVNATFGSIGSAPTASSPSSSTGSTSSPLHSSSSARASAATATTSSNASSLWLALMLVLVASMLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI59</accession>
    <name>A0A2S5BI59_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0669</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI59"/>
    <dbReference type="STRING" id="741276.A0A2S5BI59"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="561" mass="61190" checksum="74C0FCEE757F452D" modified="2018-07-18" version="1">MLRGACRSAAASLSRRPPAPFVVPLPPSPPLQALAATRSQTWHDAARGIATTSHAQAAQRGGKAREDSSVLDLFLGSTAESTAAGETTTSTTPRTDREIPPRGKSDTSSATGGGQAPTVPPARRGLFASLLNRRNPVRSSPHSQTLANPSSSPRRSSLGSVDLEEERLTRERNLETAKALERTLRSSRGTAVSGGAAGSGLDVRCTTLDARGQVSSMVAHVPKDELCRRYGIQPRDLRKLDSAVPTSVPSILSRRNCIILTMLHLRVVITAQEVTIFDSVGSEDSWLKGVFVWSLEHALKATGKAAHGLPYEFRALESCLISIVTALETDLANVRSHVVELLAHMEEHIDRENLRLLLHYSRKLSVFQKRATLVQECLDELLANDEDLANMYLTAKLQDKPRADDDHEEIELLLESFSKQCEEIVSEVETLEANVRHTEDIIELILDSNRNSLLGLDLRVSIATLGLTAGALVAGLFGMLMSRLEETPFAFPLVTLTTFALAAFVTSFGLRRLARLRRVNLGWRDEVRQLHTGDKWGMGGRRSARGSHHGGTGAAARRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIA9</accession>
    <name>A0A2S5BIA9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_0684</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIA9"/>
    <dbReference type="STRING" id="741276.A0A2S5BIA9"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000017">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor 30 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="224"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY76483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="333" mass="36228" checksum="E1B8186A9A02A9C2" modified="2018-07-18" version="1">MASVVETDARHLFLHSDLSIEPFLKNELQLRLDSDAQLCPAYTASQSCPRGANCPLRHVQPSPLNFQPKPPIPASQHARTVCKHWLRGLCKKGTSCEFMHEYHLRKMPECWFFAKYGFCSNGDECMYLHVTEEMRIRECPLYRKGFCPQGPNCKLKHVRRVMCDNYLVGFCPKGKDCPLGHAKFEPEPEPPLSSTRIPDVSGARFLPEATFRLYRKDWLEHAADPSGRSGAGSGGDYRQRHNDHSGGGQSRPPMGAGMGMGGGAGGMGDGGGGYSGGGKRDLATVTCFKWCPNGAGGAGVDLSTITCFKCGQTGHFANHCPQSAAGAGGARRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIE0</accession>
    <name>A0A2S5BIE0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_0371</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIE0"/>
    <dbReference type="STRING" id="741276.A0A2S5BIE0"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="17">
        <location>
            <begin position="6"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="16">
        <location>
            <begin position="438"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="443"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="443"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY76530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="768" mass="85699" checksum="2BABE95241BB421C" modified="2018-07-18" version="1">MAIASAALGFPRIGAKREVKKASEAYWAGKISAEELQKVAKEQRLQRWQTLQQQGVEIIPSGDFTLYDHVLDFNYTFNIIPKRFAEAKLSALDRYFAMGRGHQKDGVDLEAQEMQKWFDSNYHYIKSEVSSSTEFRLNDTKPVDEFLEAKEAGIQTRPVLVGPITALLLGKAGRDEADRASFEPLSLLGKLVPVYGELLKKLQEAGATEVQIDEPSLVMDVTANLAKEYQSTFEALAQAAPGLKITLATYFGRLDKNVEYVAKLPVSALHVDLDRAPDQLDQVLAAVKPTQLKLSLGLVSGRNIWKNDFAASIAIAKKAVEALGEDRVVVASSSSLLHTPVTLANESRLSADVKDWFSFATEKAAEVATIAKALSGADVQAALDANKKSIDARRAFEKDSDASVRDRLNKVEPAMYDRKSAFPTRKAAQDKVYDLPTFPTTTIGSFPQTKEIRLARSKNTKGELSTEEYEKFLENEIKSAVDFQEAIDIDILVHGEPERNDMSQYFGEQLQGFVFTENAWVQSYGSRYVRPPIIVSDVSRPHPMTVRWSSYAQSLTKRPMKGMLTGPVTILNWSFPRADVSKEVQCKQLALALRDEVCDLANAGIFAIQVDEPAIREGLPLRQVDWDAYLTWAVDSFKLATAGVEDKTQIHSHFCYSDFGLIFEHIKRLDADVISVEASKSDLKLLEVFHKHGYENLIGPGLYDIHSPRVPSVQEMKDRLAAFMKALPSQKYIFVNPDCGLKTRGWAETKAALENLVEVAKWARQQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ73</accession>
    <name>A0A2S5BJ73_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ73"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015577445" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="270"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="332" mass="35266" checksum="0D9B3F040617F9BB" modified="2018-07-18" version="1">MIGKTLLFVAASTSFAVATLDVLPFSYGRFPCTKWHSDGSMYADDSMCQHDQLKATGVSLDSLSTYQGYKRDRPIPTGSHCEQDPDSGSYWCGIEGAQCDDDDACDCGTCSESGTCSGGYGTVVPHNSECSGYLWCTPLFSTTTVPGGCGGDNAFCGDWDQHDLSTCATDEERWSRFDRNCHSGKSSYCNSRTSHCGHKCTTAGCDCTSDPEHACGEGLKPVIDPSCDKCTCQPIHNGSQRARARRNVRLVESLCPKSFSACTIGGSKGFECVDTQTSLEQCGGCLESGEGVDCTTIPNVSAVGCVAGVCEIWACDDGFQYAPAENACLPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJA3</accession>
    <name>A0A2S5BJA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJA3"/>
    <dbReference type="STRING" id="741276.A0A2S5BJA3"/>
    <dbReference type="OrthoDB" id="2530330at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015571723" evidence="3">
        <location>
            <begin position="23"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="372"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="473" mass="49080" checksum="AB9AF94362BD8FA8" modified="2018-07-18" version="1">MPAFSQLAALVLLASGSAAVAAQAANATVQSSAGASFGKATSTSQSVTSSGRAEATSSASTAAATAAAETDVAKAPSVSLQQQYIMAYKEYVYTDTEAFCADWDSSCVEYLSTFSDIHQVICDVGVPGPEVHVYCGGNTVVQPASFFDFTNNVQRFVSASLISGLASYGEVTNGGNATTTSAPISTSSASSTSPLTSAITTGSPSTSSVASTSMLNSSRAASQSSSANAQSTSTVFSGGVGNATFTTSSSRTTSQDTEVPRTSTPGAGSHSSSLDGHASVTTTRPPITPVRTESASTSARQTATSTTSCLPSTPTPSESLPAAAVAAIAAANAARDEALAHLRANEALAAKRLRALAKAKMNELARIATLRKKQLLQAIARAAQKAEEEAARAIAKAERHAQQVEQREQAARMAKERKKHAHDLWSVEAKLKSRLGAAGLQWLEDYIEEEVKKDFKAELKKAREQHLIRARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZD7</accession>
    <name>A0A2S5AZD7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Osmotin, thaumatin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_7088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000169">
        <property type="protein sequence ID" value="POY69908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZD7"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013">
        <property type="entry name" value="THAUMATIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013:SF2">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015670526" description="Osmotin, thaumatin-like protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY69908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="43569" checksum="4544EDD9150BBB8F" modified="2018-07-18" version="1">MLLLSSLFAAACALATAQRQFVVVNNCKETLWPALTNQGDPSTRTYSGIRGWEAPPGHVQQLSLPSNWNGRIWPRRHCQFDGTGRGSCLSGNCAGGLNCGDNEGDFLSLGEWNLNSWGGLDFYDLSFVAGFNIPMSIAPDGCQALTCSQDLNTICPDERMRQRDAAGNVIGCKSACMAGINAGIPSMNCCSGIYESIPACVPSGVDYYDIFKPVCPSAYWYRRKAHLSRTIASTARDQRDGNPQVDWACQAGTNPKYTVTLGPTDGAKVGKTNVAVDNESASAAGGKSSSATSTATGAAKTVGSASAISSASSSSASSDAASATSTAEATSGSADGKILGLSKPIFFSIVAVAGAIVVGVIACFACRRSRSRSAVAATATVPVADNELGMSDSEEEQREKRNRRRYSEDGSPLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZE6</accession>
    <name>A0A2S5AZE6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_7055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZE6"/>
    <dbReference type="STRING" id="741276.A0A2S5AZE6"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY69923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="229" mass="25318" checksum="77CEA00B34A94334" modified="2018-07-18" version="1">MSGWMSWITGSSAAKSKDSTREAIVNLREHLLMLDKKEEYLGKKIDDEVRKARANATSNPRVAKQALRQKKLYEQELESISGRKMTLTTQRPTHQVNAIESANMNKETLEAMKKGADVLKGIHGKLNVDKVDATMDEVRNQLELTNEISQAISDPAGMGIDVDDQELADELAELEQEELNKRLEGAEAAPMHSPAAAVPAASAAKTPAQRIEEDEEEAELRELQAQLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZF1</accession>
    <name>A0A2S5AZF1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_7052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZF1"/>
    <dbReference type="STRING" id="741276.A0A2S5AZF1"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF6">
        <property type="entry name" value="GB|AAD46013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY69920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57131" checksum="404CADD35B0D11AC" modified="2018-07-18" version="1">MDEDFNDQRQNGGGASSTRSASPEPLATPTLAESYGSLKKNLSVKNLRELEMRELSEHIYRRGKRTDNLKYRPKNDDETFTHALKGGVRSLILGCSLRAAVNLVIVLLRLTRKRGIRPRLILHALFGSDVFRFGGMLGLFSFLYKWTLHTIRLYNPGPLGPGQSERWHAALAGLVSGLSVIAEKPSRRVTIGQQLFVRGLQGHYNLLKSQGRIRVKNVSVLVFGFACAQIMYSWLMAPEALPSGYRRWITQASRVSEPCLPVNRSTGRSGIFDPEVALKTLTWGRGATPKNRSLIQAYADRGERGDFGPPFAPCATIHPWADTCTACAVDRWHHVFRWIAPVYAGLHFIPPILLRSKAWMKSPQTYLYRSALNTIRSCSFLATFVVIFQGLVCFRQHVYAALAGRVPTWLLGIVQHRIYYWFCGFSTCLALFIEDPKRRRELAMYVLPRGLESMWSTLRQKSYVPFVPGGEVLLTSAGLALVMQTYQSAPEHLSGLVRSFLYQLIGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZK6</accession>
    <name>A0A2S5AZK6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_7011</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZK6"/>
    <dbReference type="STRING" id="741276.A0A2S5AZK6"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY69967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="90" mass="10250" checksum="CF4566BE93D6D111" modified="2018-07-18" version="1">MNAANMNPATAQAFEGMMQQKQMKDFMSLYSNLVERCFLSCCQDFTSKALSSKEESCVMNCADKFLKHSERVGLRFSEQNAEMMARASQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZR8</accession>
    <name>A0A2S5AZR8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_6964</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000153">
        <property type="protein sequence ID" value="POY70027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZR8"/>
    <dbReference type="STRING" id="741276.A0A2S5AZR8"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="255"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="654"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY70027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="960" mass="105164" checksum="1C37E12314116669" modified="2018-07-18" version="1">MQSAPLRLAAQEPPEFPFTDAEAPRPRPSPLASRRSSLLQSPSASSDKLAALFGKAWAGSDEEIARRHEAEQKAFAENRELLVTSLDESTKLVKSLSVFNQSKWTVHYPHQLGVATVDAPVPHRTLSTPQQTSSSTGRSPREDALRRSMSVRPSTSMQDITEEDAKPAGTLRPEIARAHSTSGVDVNPSKSSVPTPPAHPLSILSIDLKMGHPSTSTAQLPALIPSLSMSTLSQLLSRRLSSSVNHLSSLRTRVLDQSSRVLVTGDLNAGKSTLVNALLRREVMPWDQQPCTTVFCEVVDASANGGREELHAIRDLEKYHRADKQTFDAYPLEQVYDVQEMTGEYHFVKAYVHDNRAPVVADDAEEDGASASFLKNGLVDISLIDAPGLNRDTLSTTALFARQSEIDVIVFVVSAENHFTLSAKEFLWNASREKAFVFIVVNKWGGIRDKARCMRVVGEQIKQLSPATWENRAELVHFVDAAEHVDEVDQPAEVQVDSTEPSAFDHLEQSLRSFVLLKRSQSKLAPAKHYLLNLLADLSTLASANVVAANEELAAALRELERIRPIHERLTAQRDEVEDGVDRVEETVVEKVKGAAWSRLDRALSYIYDGKVVPAQETIAEADARPTFEHADSFEGPAQLPPYPGLFGIWEWAADVKKTLVRALESEVRAAEDDARTETAAGVKAVMTDLGDKYLPEVAGEELTAEQQRQKANRVFRPEVMFAKRRRGVGRLAARGISTGLGLGSAGLGVNWSATDFDVSFFDMFDLERMSSHGAALRGRKQPKMIEDDIVEKGTIVGLGLGSVGMIGSRLIGIRGTMSSLTRIIEVLGSKQARKWAGPVIGVLTVGLVVYVIVDLPRAIPRNIGRKLALALSPVPTDSAAQPVTFASAHSDRISREVRKVLRLAGWDLRERFRAALDKSAAERKEVEGVVARAEGALEFLSEFERSVEKSDEAVQAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZZ9</accession>
    <name>A0A2S5AZZ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZZ9"/>
    <dbReference type="STRING" id="741276.A0A2S5AZZ9"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF42">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="72713" checksum="0C6A56BD8A4D862A" modified="2018-07-18" version="1">MTTDRSARKRPVRVAIVGTGLAGLSTAYFLSTLDAIRDQSEEEERLQFEVHLLDRSDSIGMDTASLSIKSEDGQAASYRVDVPMRSINGGESRASIESPWLGSSHGRVRRLYEHLGVPLVQSDFSYSFSRLARSAESQSRLSPAAAAGGEAGEISEDGLRPNNGEVGSAAEDDSLSDEATRTPPPSYTEAAEGTGLPLSTAPRAGPVDLDSKSPSSPLRLDRPESTASLLYQGASGLRWPPVSLPSHLGRASLRSRLVYATQTTLLAISYLYLLVLAFVYVSLGLARPRSAAHRQTCHSPLVRRTWELSGLAELLNVAATPLGEFCLRHRLPQRLVEGVLIPLMAAVATVGVDEAREMPTGEVLAYIVETFAHSHYVTCPSVGVRGIVRRLVAPIPPAQIHLGADIIRIERVSSSVVEASPYRIVYRSDSDGQQEEATLKVDHVVFATQADQAARLVSTLEGEDCKDSSVRETVEALEAFTYVRTLVVTHRDESVLPPALDDRRDLNLAVFEPPLANASLPGGTGAADSWDESLGHLPPSSVQTTHILSARSQNSSSPVLQTTNPVIPIDPDRILASTWFSRAFATAESQAVLGRFLLPADPAPSRESSPASLQGQALGQLKGTESSRAEPHAGGIWFVGSYVATGFPLLEGCVSSAEAVVRELVREQGGHVQRWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B076</accession>
    <name>A0A2S5B076_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B076"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF63">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID PMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="333" mass="36866" checksum="789F1CDE2233F7A7" modified="2018-07-18" version="1">MDATIRKHMPKSAKDLKPNRTHAFHGVIMVLGWVAPPVAVLVRFGVGWDLVLNTILTICGYIPGHAHKCYIQNIRNNKNHKRTPKWAVRAGLVKMKDPRAGRHQWATRYDERVGGGGGDTDSLRSNSWDGRGAEPERRAKPLNTRRKHRHTLSPWDDYVDEDEVEGGEPGDGLYRTESRRFDPPSRTSTSSRPTEPVADPLTNEQFYPQPVAAPLRATPTGGKKKFGSALLKNRSRYEQPFDTTDAASSRTRGSDGFQDDFEREINGGAQQSAAYSSSRAGGSAGRFDTFEAEGPEDAWGSARPANGSSRAPLRPQKTGRAEETDGDLFKHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0A3</accession>
    <name>A0A2S5B0A3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6797</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0A3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0A3"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="696"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="858" mass="96439" checksum="9BE054B3F1DC1B12" modified="2018-07-18" version="1">MDRSEVSQYPSLLRSEHMSLVQLFCPIDIAHSTVESLGHLERIQFKDLNPDVNPFQRTYVSQIRRCDEAERRLRFLTQQIAAQEIHIRPFQETSALIANMSGPQALEELDSRLGESEQRVVAMNSSYDNLEKRALELEEARQVLRETERFFHEAQGRSRDIRSSFEQEEGEALLGSIEAAGLSAGEGGVGGGGFELEFVAGTIDRARMATFERVLWRVLRGNLYMNSAEIDDSVLPVPSAGGTAESSDSEEKKLRKNAFIIFAHGSDLLDKIRKIAESMGANLFAIDSSSDKRSDKLREVTSRIEDLNSVLYNTNQTRRAELVKIADSISAWWALVRKEKVIFATLNLWKWDQGKKTLVAEGWVPTRDIPQVQTALRTASENAGTSVSALLHELRTTKTPPTFHRTNKFTEGFQNIIDAYGIGSYQEVNPGLFTVITFPFLFAVMFGDIGHGALMLLSALALIMLEKKFAKGTGNEIFDTFFYGRYIIFLMGAFAIYTGLIYNDIFSLSLVIGPSQWRWPDDVTGAVEAIQTNTRYWFGLDPGWHGADNSLIFTNSLKMKMSIVLGVLHMSFAICLQVLNHLHFKRPELILAEFLPQILFMESIFGYLVVCILYKWSVDWEAAERQPPNLLNMLIKMFLSPGNVAPEEQLYSGQAFVQVVLLLLALVCVPWMLCTRPYLEYREMQKIKEQGYHGIGSSGHGANGDHTTDEETDGEDGHAVAQPEEGAEESHDFSEVIIHQVIHTIEFCLGCISNTASYLRLWALSLAHAQLSEVLWNMTIERAFEMQGALAIVFLFAMFAMWFTLTIAILCVMEGLSAFLHALRLHWVEFNSKFFAGAGTAFEPLTFEGTDEIPEGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0A5</accession>
    <name>A0A2S5B0A5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0A5"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="56165" checksum="FB6FDB62D7D5B101" modified="2018-07-18" version="1">MAGTETTPLLHADGEGQQSTTVQESRRGVRRTAALVIIPYFLFSVLAGASATVEIEAIGQIACRLVVAVPVPSASDKERLEWEAMCRVAPDVLARTSSVVTEILLIAGVLSAMTAAWWGGISDRKGRRIILGITSAVDIVTNIVMVLVLAYPAKFGYGWLLGSAVVAGLGGGQLASTAIGATYLSDLATPETKTQILSLYEAANWGGLALGPLLGPYLMQVRGLGVTAPYVGLLLSRLAFIAMLPFLRETLPAKRVDLFETSGPDEVPDKPSSFFASFFAAPLALLRPLSVLVPDKVNGRRDYRLPLIAASYGLFMIVPGLGPVKILFARGQFGWGPLETGRFITFTGILKLVVLVGVVPLAARLLRKADTPTNEPEETMEDIEVPVSSSRQPTGSRSSVWDLALAKTSISLALIGYLAMLLPARNRLMPFLVGSGFTAFAAAAPPAILSLALAFSPAEDSGKVLASLSAIATVSVTAIGPSLFGAVYVAVLRWWPQFVFLLAAMWVASSLIPLFAIRLRRPGAAPLPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0E3</accession>
    <name>A0A2S5B0E3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0E3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0E3"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="99" mass="10994" checksum="56A5DAF8443A496A" modified="2018-07-18" version="1">MLYVSHGAAIREFILSLVEVADRKDRDYHLELPAHEANMIRSGSKRIDNCSRTIIEMAWIADESGGGHWQGRLQLYADGAHFVDSSRAPSPTANADVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B136</accession>
    <name>A0A2S5B136_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B136"/>
    <dbReference type="OrthoDB" id="2520637at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="85" mass="9587" checksum="1880645F4BCCED13" modified="2018-07-18" version="1">MSSDPRDDVNSHTQKKPVGAERGAIVNENEQYFRDPPNNLGLKHPEEQDRASDLVGSTSTVPVSDNEQTEEEKKRVRELAEKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B141</accession>
    <name>A0A2S5B141_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B141"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="160" mass="17711" checksum="B9EB646D2FBAF0C9" modified="2018-07-18" version="1">MASQLPKISHVLELILYAQHLPRSVDFYRSTLRLGDPFLSNDRMAGFSLGNGTTLLLFQRGATTKDLPMRAPEQPSPVGTPAIIPWHGLGPEHDGVKLKTHFALAVDKPEDVDVWEKELSDKKVPLLGKVQWPGGGRSVYFADPDDHVGELASHGIWPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1E0</accession>
    <name>A0A2S5B1E0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1E0"/>
    <dbReference type="STRING" id="741276.A0A2S5B1E0"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="333" mass="35601" checksum="7330EA3E82131A64" modified="2018-07-18" version="1">MGLHFKGEKVKKKSKSKSKSSDAGGSGPTTRDDPDAHLEGWVQAPSPALLLGPSYLTLPATAVTPAVCVATNPTTAKVYPFALPTASSSTPALAAAAAGPTASTSQATPSHLAHLDAEELEALVDASDPALAAMQDENPEPTDVHHVWVCARIPDTNDKVTFRSGMGKFLASDELGRVSAEREARGMQEEWTLEAVEGEAPRSGRMVIKSAYGKYLSVDVVAGGKVELRADEDKEGDTERWKIMMQGEFVVKAKKQYNERNGIKTKPDAGYTVVTDLAGAEVDAISKYHHHARGADAVGTADDARALKKARKDGKLAEAMLDRRMKLKSDRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1F0</accession>
    <name>A0A2S5B1F0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1F0"/>
    <dbReference type="STRING" id="741276.A0A2S5B1F0"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="155" mass="16902" checksum="33C5515CD4A0D591" modified="2018-07-18" version="1">MASPAATPQVRVGVGCFLFRSNGDFVTGVRKGSHGAVGALQLPGGHLDFGETPAACAAREVFEETGLTISDGDIHFVTATNDIFKREGKHYVTLFMACRVSDDVQPRVCEPEKCAGWTWHSWTDLQQLASAPDNDLFLPLQNLVKQMPNLDLRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B244</accession>
    <name>A0A2S5B244_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B244"/>
    <dbReference type="OrthoDB" id="2521637at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="36437" checksum="453C6E4E35F3D8DE" modified="2018-07-18" version="1">MSDPQDVPALIAPQAVASAILAPYIAGLLTQVLLIGAFLVMFGRYAVAGEIQKHGFAGRLAIWTVFALVLCCLGVSYEEIIDTGISQKRSSDEIFQGPPQSNVLPVLSGLTAAVCQFFLAGRAASKRLHRVAFFATVSALTTLAFVGSLLFSATGFQLTATGESVFNYKAAQAIWLWASAAVDLLISIALSHTLHSRIAHFNEVTDSLLKRLIVTSLQTAAYTSVISIIGPLPALHAISLYTTLSTRRSISDTLSGSGQHQSITGARSHNDGNLTPGAGPAFRLSTFKRTGDATSSSYALRSKRDSPPPLQVNVQREQTVSFDVRSEYDEEYSVEKAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B260</accession>
    <name>A0A2S5B260_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B260"/>
    <dbReference type="OrthoDB" id="2538274at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="480" mass="51355" checksum="10A39A59BC5217CA" modified="2018-07-18" version="1">MDLLTQPFAHQLSTPSRPAPADLTSTSHEGGRNVDRQPSIDDRTSIATTSTSDAVQQSAANFSQLRTAPASAAGLPNEPRVEAPSVVKGDWRVYGHVKAQCIFWNEGALAQKGLGSNWRKEREKLADVHEWAGEIVFVLDPASPPTLVDRPSKPTVTGESDDAERPMGSARRLSFSSLGRSISRESRSSGPGPVTNQPAPTSEFPEPQGGFRGLVKKIVSAVSPSSSKKELPADAAAAATPGDALHRVTTHERQAHAIEEDVAPAPQTELAQHEPASGTGLTFEEPETGRGKAEDPLPAFKGYAITALSVGSASRIRSMRFFPRRAVPTTSPNDLPLSSTELHDLIDVGGEKVHPPVVELDIAEWIAPEDGKSAFDEENAPIRKREVTIGFAFRDVLLLHEADDFRARVEALVAAVPPTERSASPTFGATLMRTISGRSLGRTTSTEDQATPPPAVLKKGRRGSKSGSWLKAKPQGDVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B298</accession>
    <name>A0A2S5B298_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B298"/>
    <dbReference type="STRING" id="741276.A0A2S5B298"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="408" mass="45371" checksum="C75699898D7B4BD7" modified="2018-07-18" version="1">MLRAIRPRTIAWRTRPASARRGIALLPEASNAPLAGTDGSGPPWLFLLQIALGLPTALWAYKCFMLVLFQRKIIYLPSVPPGTRSEPVPKTTGDLQIDEIRLQSSAPSRWTRRPVTLRGIDVEWRGDLESESLTRQRVVVVYLQGNAGTPLLRLPLFRALLRPDRFRKDDFPRISIYAVAPRSFWLSDRSAPTQQTVLADYEAALAGAVRKYGRSANYVLYGHSLGGAAALLMLGRQRSVGTSTPPDPALSGLILENPLPSIPYMVRALYPQRWLPYHYLGPFAFDRWDALEATRTASGDVAKPPSLWIRSARDEIIPHDATDDGVRRLYESWNATTWPRVGPGERAGRRGQARWLDVPDALHDTAYGSRVWRDEIRSFIAGVVGNSPDDGAGSDHRELRGSPPVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2F3</accession>
    <name>A0A2S5B2F3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_6025</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000093">
        <property type="protein sequence ID" value="POY70963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2F3"/>
    <dbReference type="STRING" id="741276.A0A2S5B2F3"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="191"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="423"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="813"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1109"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="869"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="952"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="995"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1109"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1121"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1144"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY70963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1164" mass="123710" checksum="0F587D1F80F9A168" modified="2018-07-18" version="1">MFCRSLVISFDSDHNHIRLMPPPAHTPAPAALRAPPAPPTLPGDFQDAATAIERRLVDVEQYQVPQLAECRGPLSFHNELATAIRQELARARRDLDELKVEADDLDRAKERVAASQLIASIQQRLDSCTRAYRQAVVASKRQIDASAHLVAREELFASTSGRGSPAPGAGGSARAKSPMPGQGGDDALMQATSDVTEGLRRTLQLMQQEIDRSMVSNELLESQTQTMQLTSNQYSTLSSLMNTSKNLITTLERSNILDRLVLFGAFAFFAAVCAHIFKKRVIDRGVHGVGALGGIVAKGGGAVAGLASKAQTSDAIAEEATQVVKRGVADEWARATAAAAGAAGAVRAGIDMARSKANQVVTDRDVPTQTPSLVDSARHPSPPQRDAFEEAVPFEEEPFTAPVQSETDSDADSVIDEMTDSARESVRIVEDDTSLEEPVATAAVSDEPLKPAVVEPLDDHYDDTVSDEDGYPASDEESYDSEDLQSATGIDNDDDDADNDDDDEVTFPEAHEAETVAPRQPHPPTPSLPDILDLAFETPNAEEPPARMPDLQDDALSMDSGVALGGDDDHATKFDVEEDWSDEGEGLIDPIVEGDPETSADTEGETTVGGFQPDPVEAEAASDPEEFEEELVALDVAGVVGQDSASTSAEPLPSEPLQLLDLDLPTDYSDLDLDAAPEYVWPVDYESTLQAEPLDGIEVQSLPRDVAGVEGTTRPLDIVTEEDAPPPLDVEELGFVPASDATEIGGQAVSADLPIDLDTEQTIWSDSTATKSLGDESAHYLDDVTTDNVPYEEVEQADESLLEAILEQQMGYAAGPGAFGDRPDFQDAERDGTGEALSGPVDTEGATSSLPEEVAPDLPPASEGRALLGDDEDEDDDEEDDHDPAEMASVHEASTYASTIAPTDEPTAPATSEDLARTMPPASPHAASTSTSPDAAASVDADDLPPSPTDPLEPAAPAAPVSAPEGAAVRSSAPPPEENHADEGAQSRSHRATEAAQTPASSPTHDTAQLEEPLLQQPELSDELELASAPEDSLVPTHAEAEIVEHGTGQADAHLDEIIEPSADYWEPENVLAADPIAVSTYDDDLELPESIPQTAYDRDFVEDIDEVLGSDLAPNEEGETSERHAEDVDRTPRGEETSAPAEDAAEDELDDFADDEDGIVRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2G2</accession>
    <name>A0A2S5B2G2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Stress response RCI peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000091">
        <property type="protein sequence ID" value="POY70969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2G2"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF40">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015412135" description="Stress response RCI peptide" evidence="7">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12584" checksum="CBD4B6B5BB4BACF6" modified="2018-07-18" version="1">MARSSDILLVLVAILFPPAAAGILTGCSCDLFINIALTLLGYLPGHLHSFYLIYRKMQAEERYGPDLQYFGNAEWGPAGGAHHAPGYVHAQQQQGYQAVPQQQQQQGYQTTYGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2G7</accession>
    <name>A0A2S5B2G7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B2G7"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="261"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1400" mass="150332" checksum="DCC8FAFC6E6DD8F5" modified="2018-07-18" version="1">MEGSASTGAAPSRGRGRGRGGARGGARGAGAFGVQRHTNLSWRKPDDADSPAPDTDDAAEEPSQQATSAFATGGSALSAFGATSSGFGGSAFPPSGELSGQPAASTSAFGTPPSNPFGNKAFGDAAAAVSNAFGQAPKNPSHTFGGSAFSGSAFGAPLSTGTALFRAPSQQSDGGSGDAAVVSVPERRAPGQASSLEVLGEDSDARKKRFEATLPNNRYLELKPLREEQRLAEIRAGTIPDPSKPMRLDQATDFEGTCEEMCPEWEREEREYQNNVDPLERYPGTTRIDPSRAVKAFHRPAAGNDQPLPSDVRPAPVLHRTLDYLFHDLLPTQPLAATHPFIRDRTRSIRQDFTVQNLRNIDAIRCNERIARYHILAVGVLREETGFSEQQELEQLRKVLKSLNEFYDDIRLSGNADPSENEAEFRAYNILTHLRDPDIVWSVELLPSHVFSHPLLQRALALHRLAQKANVPRGERASQNAFSRFFTLVGDPATPYLFACILSTHFHDIRRNAIDALRSAYLKQHSAFPLRTLAKVLGCDDEDDARSMCEQLGIVVRDDDRGRLVAELHKQAAMKGGALKPKVARRLVEGKRGDCPYPRVIDGTFQASRAVGQIPATPLLATRVSPAAPRPPLATTSALPTVVAPANPPPRRDGSFNISQISTPIPTPPRIATPVPAPARAIASLDAAAPSFVPTSRVPPVPSFKPQDVRSGGFAPTAAPFVPAQATTALEKPPPPVPSFSAPTTAPSAPAFSAPTPSGTSQEKAQPSPPAPPVAIPPTIRKVSLPQISPVRPSLAAQVALVRRNQLVQDLVHHFTAVFVRETIEGPVHRAATTALKERWADIRAIEARAKQATAATLASDAIRELGRLATRETILAGWRDARCLQSVWDDWRRALKQSLTRKARDAELRSEWREVVGALEAHPAEEAGDLAMAADAEDDGLAGLNDLPGLSFDALMIGSMQNARGASATDDLDFVSRLSSAAVERDQIWAPGTFLNIAADLASEAIKKVETQHARPAWDVLVSTSTTGAPYASWLACKFDLDPSDLTMQIDTPEADISVTMIEHGTKLEQKLLVNVGLVVFVHSGDAPTNSRTHLHRLMAKLRAESLFSPALLVLDYTEAGASDPADTLSLGSLDGLVAWRIYRPDLAASETGFARCVEELLRDLRVLPGRFRLSLEASIRPLREAWKASMARVTVDEVTTTPVAFASAGLQILRSIASEVEGLAMDRSGPPLSIPDLPIDPDFFVQSVRVIIQDTAFAQAANFPALETLLASRPPPSAAVLARALVEHVADFVFSTLSTRRSRQDAIANEMPEVYRSLKAALIDLEERFKPNRRPGSTASKKRRASAVQEAEGTVSSPKKQAGPANAVSGAAASMPPSRDRLSALEVLMRDARALIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2I9</accession>
    <name>A0A2S5B2I9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_5927</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2I9"/>
    <dbReference type="STRING" id="741276.A0A2S5B2I9"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="19">
        <location>
            <begin position="639"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="676"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY71002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="715" mass="79907" checksum="047750971662A0FB" modified="2018-07-18" version="1">MGSAYDKWQLDAGGSDDEEELADEYRQTKEAIYWCIEATPTMLAPVLDQPGGAASANRALPTPTPTLTAPAGSARPAATQAIVWQGPPAKSKLEECLRCIYAMMKRKVISSPKDLIGILVWNTADTVRSITDNCHLLFELKQIDAGMIKKLREILQRAEKDPDYLPNLFKPRENDTVIGSVFANAMTAFREASPNANNCIFWVTDNDDPVSGNTQLTDVMRRKRMDVDESGFGVETFFVPSTPGDDFDLDKFYGEVMTVQQDDEADEMVNAPIVSHDLRAALESMVAAMRTKETAKRVAFKIPFVLGKDLSIGITGYNMIGEEVRKPAVKVDLNTSGGDEIVSKVVYKDSETGTELDPKRDIKKYFQVGKDDFESGAKATKIFFTEADVRKVKTLGRPPSLKLLGFKPRKDHLRFQETVKHSYFIYPDEERYSGSTRTFAALLKSMLKKEVVGFASFLPRTNARPQVVLLLPQEEKLSETGVALIPGGIHLCQLPFADDLRELGLSSTLSVVHRPDPETDDEPEQPEIDAAKKIVKNMSKVYHPDIYPNPALNYFYDTLAAVALDEDIPEPEDNTKPAYELMEQRIGKFVRNLRSMIRQDEIDPTQVVTSNKKRVIKKEQTPADAAAAEEFLADFRKRGDKLKLDELKRGLRLLELPLSGRKAELVDRIQAYVARQAEQGASGTAKMEVDEEEDSSSKPQKKKARHVLTIEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2J8</accession>
    <name>A0A2S5B2J8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5933</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2J8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2J8"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="112"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY71008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="440" mass="48642" checksum="20A9C5AC9FD48B2F" modified="2018-07-18" version="1">MSAPPPRKKSKWDKEDEQDRAAAELDRKRAAVAARLAREKDLAGREPASSRGSSAALASPLRNGAADGGSDAGSAGGSRRVTPGQPVPRARRPKRGRAAHPLLDSCRSVYSYERLNEIEEGSYGIVFRARCKSTGDIVALKKLKMDKEKNGFPITSLREIQTLMSVPHENIVRVREVVVGDTLTQVFIVMDFVEHDLKTLLANMPTPFLASEIKTLMLQLLSAMAACHDNWIIHRDLKTSNLLMNNRGQIKVADFGLARTYGDPLGDMTQLVVTLWYRAPELLFGATEYTTAVDIWSIGCIFGELILREPLLPGRGEIDQVNKIFKLLGRPTDEMWPGSRKLPNAKSFNVDAAQPYSSLSRTFRYLTQAGLDLIQKLLTYDPEKRITAEEALRHPYFTESPLPKDASLFNSFPSIANGEKKTTLASPSAPERAAGGYDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2J9</accession>
    <name>A0A2S5B2J9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2J9"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="530" mass="58072" checksum="0043859157334BE5" modified="2018-07-18" version="1">MQLSLLESLPDEVLRQIFRHCDLPTLLQLSATNRALHEVITLFLPSCTRSRYNYDPQTLRHLGFHTRAPVAQRALWAERTTRRWREWDGRGAVIGGAKREWRRCLPTLKIWDIEDGVGAVLVAKGRELECWITRQDGTVEIAQAVVRPPKRAQSRQVPALEGAAQHDVTALAVGPQPGEIIVSRVSGVVQRLRLVEHAAPGYPFVLEEVARYALGSSKSAGESPKTGVHAIHSRADLLVGAVTTRQQPPSHVGADLPVVNDPRGPIASLALTLKQRSAAQSHNVSIQSISSPWQSAKTIPFPTKPWSVHLSPFRSWLAVGHSGTAPLSVFQLDSTGAPFTVPSQIAHTSRSTSVYSLTTPSPHSSPFSNSEQTLIAAFYDATTRVYDLRVPSFGPLSDWDAHESDAKPPNEVVRLVDPWSDDPCYSVGIGGAMGSYVAVGSARNAAVRLFDIRSPARPSGITAFAPGRDRSPIYALEMEGSRVWGCTENRGFVLDFEAFEAPRRRTEPVAYVSHQDGEGGTLRWMGDHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2P1</accession>
    <name>A0A2S5B2P1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2P1"/>
    <dbReference type="STRING" id="741276.A0A2S5B2P1"/>
    <dbReference type="OrthoDB" id="2534116at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="49737" checksum="3C4DF74D30CB22A9" modified="2018-07-18" version="1">MPPKPKGLKASKRAAPFDPSTGSDAASATASTSAAGAGPALNKDKTMPLDEDALTVLDLFELRHRVLEILYPYPTSLRYDFGGDPDRLEDARNLLRGILHGCDMLEPFLSEPRRQEMDQDKLDALGLGDQGPAGRHLRYLQAFSLRILGEFFEPATVAVPVAGTKKRKVDLREPQTAKEWFETADGRLSSDDGVNDDADRIFSAVVAAEQAHLHAVSSASASIEALPDLASRVTTLLDHPESFGAKDEQESNATSLDSDDAFYAAYRAITASLVALEAHRDPSRLCDSETLQVALCTVVLGERPSGPEGLMRWLSEVVRADAELAQFGIAEDWIEDKYRASAEDEEADEDDEVQPLPEESKEDVAKVAEMGEKAIASIRATLAKFAELPADVAHPSARTAQYRKLEEALLLSSALIDPSNDAELDKLEAEVAKIREEGGLAEPEEEEQEEEPEAEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2T3</accession>
    <name>A0A2S5B2T3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2T3"/>
    <dbReference type="OrthoDB" id="2525594at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="560" mass="59155" checksum="0080C60CE92D900A" modified="2018-07-18" version="1">MATQLAVAGLSLLPGGSLLVDTTRRAYTTTSALRAAWNNSVYDHKVPELEAAPSRPLTPVFCASPNLHRPTSPSSPLPPTSPLPTSPPLRPLMLSTLRRRSSYQPGERPAYQHHHRGPSTMELGTTCSGCGSHVAVEVPRWMLSAIEGAHNYSGHLQGAGYGSGTRQIEDEFGARALTGRQTGPRRSGRARIDWRETVVHGAIGTAKAVKASPFPGLVLTFFRALLAFMLLLDARFMLHQRAAIILSRFLEGLVEIEREVGVMRGAGEALSIGWEATVKGVIAFAKAESTADKPDTAPATTTIFTRQPQPHQAHPQAPARVGSYFPPYQPMHFDEGPPFFPPSTQQQVGYQPLAAGPVMTEDEAESPRLGVDYSHETSCPPSPPAPNHEALSSLSRPLRRTPLSSPALQTAYADGQAPSSAISTSRSANAISSSASTSTAFSAFSSVASTAATALGHDYPFLSTDPAETLINDRSVSSSVSSSSLRGKGHHRPPALQDASLPRQRSRSGPGTTEGYASSGGLGLVDESSLPAPPPPSPIGSRAGWAGKAMLGLAGRMKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3L7</accession>
    <name>A0A2S5B3L7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3L7"/>
    <dbReference type="STRING" id="741276.A0A2S5B3L7"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="420" mass="45856" checksum="B637E9C721C7BE48" modified="2018-07-18" version="1">MSHKYDILVMGASGFTGQLVCKYLASQASVQNFTWAAGGRNREKIEQKMKEVHAEPSEIFIADSKDEDALRRAVKQVKVVISLIGPYLLHGEALVKVCAEEGTSYCDLTGETPFIHKMIQKYQRTALDTKAVIMHTSGVDSIPSDIGAFLAVQQLKQVGGEQTLAGNVRSSFKAKGGMSGGTLLSLLEVVEQPKETRDVATKTYGLSPITGKHSGRPVVVSSHTYAGKRTWGGFFLMAPVNIPIVHRSWGILENADPSSRVLRYGPNFVYDEMMALPGPISSFVASSVMLMAFGAIALFSPFRWLLRRFGPQSGDGPSEQERENGWYETTTVAKSDDGKYESRVIQKAQGDPGYAATSILISTCAICLVKDHDRLAPIAKHGGFLTPSVSLGNLLVERLEKTGRFSFTKEGRRITDKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3P4</accession>
    <name>A0A2S5B3P4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative D-lactate dehydrogenase (Cytochrome)</fullName>
            <ecNumber evidence="8">1.1.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3P4"/>
    <dbReference type="STRING" id="741276.A0A2S5B3P4"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000011">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="592" mass="63725" checksum="7E6D1B9A27FB9EB8" modified="2018-07-18" version="1">MQSTVRSLERVAHQRTLSGAAVLPSARRPISAAATARIASTSKLVHKSSATARIIPAAVRTFATTTARRAEPPPPRRPDFKKLDADDVAHLRSLLSTPDSSLVTTIPSPDGSWKEAAPEDLVSYNVDWMDKYHGNSPVLVKPKSTDEVSKVLQYCYQKRIAVVPQGGNTGLVGGGVPIYDELILSTEGMNQIREFDDVSGILTADAGGILESLSNFLHPKGYMMPLDLGAKGSCHIGGNISTNAGGLRLLRYGSLHGTVLGIEAVLPDENGTVLSINMPGGGGAGALRKDNTGYDLKQLFIGAEGTLGVVTGVSIMTPRLPSAYNVAVLSVPDFASVQKVFKETRGQLGEILSAFEFFDHEGLEMVLEHTGAQSPFESAPEEGAEKPFYVLIETSGSNKDHDDEKLGSLLESLLENGTISDGTLAQDETQVQSLWSLRESLPEAAGKLGRVYKYDLSMPVKDMYSLVEEARERFAEKGLDKDGSIKTTVGYGHIGDGNLHINIVAKDWDKKVEQTIEPWIYEATAKRNGSISAEHGLGLMKAPYVGYSKTDPAIAVMQQIRRLFDPRGILSPAKYLPQASELPLQGEGEKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3V6</accession>
    <name>A0A2S5B3V6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3V6"/>
    <dbReference type="STRING" id="741276.A0A2S5B3V6"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="247" mass="27134" checksum="9361D3A3BD898833" modified="2018-07-18" version="1">MSPYSGSIALPTRIGPLRPRSYALPGGKALTVLPLANRSQAPDQLLAFLKDTFNDVVDEGRTYPQMQQLSLDEFAAYFFAADCFLGVLDASAPAGLDNAADGLEREESLTLERVVAGRPYPECVLGMFYVKPNYPGRSSHLCNAGFVVPTVHRGLRIGSTLGRAYLHYGPRLGYRGSVFNLVYVSNEASVRIWDALGFQRAGLIPGAGRLKRKDGTGEDFVDAIVYHKDFVELADRQRQEEKEGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4J8</accession>
    <name>A0A2S5B4J8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4J8"/>
    <dbReference type="STRING" id="741276.A0A2S5B4J8"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21572" checksum="4E88B36F29B8EA54" modified="2018-07-18" version="1">MCLGWRARQERVSPAIEGLWPAKYASSHLITDRKAVGISKGSYLRVHYKNTRETAAACRGLSLAKVVKFLEDVQTHTQCVPFRRHNGAVGRTAQAKIHGVVQGRWPVKSAKFLLALIKNAQANAEVNGLDKDELYVKNIVVQQAPKMRRRTYRAHGRINPYQSSPTHLEVILAPLGAEVPAASEEVVEATEAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4S7</accession>
    <name>A0A2S5B4S7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4S7"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="237" mass="25843" checksum="7B45BAF1B9C1D6DD" modified="2018-07-18" version="1">MASPGVSPRRSARVKVVALPSPPAVTHSASPQQMDARLADQPTLTRSPEAMSARSVRRPNRRKSMAAHAAQQPTRQSAVSPLAAHDLRPLEAYCLASVERCHELEKTVAQLERDIGSKLQLWDDRLAKLAAIDAHAQKLAGSMTASLASLRASATPQVSSARRAVLDSTAKIDDRAVELDSSISSIMRARHALERLEARLDDEESTLKRIDDWQRALAWLLIVVLAGFVALVAWLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4X1</accession>
    <name>A0A2S5B4X1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4X1"/>
    <dbReference type="STRING" id="741276.A0A2S5B4X1"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001211">
        <property type="entry name" value="CBN-PRP-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="5">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="216"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="523" mass="57769" checksum="08AEEE7B5CA51C06" modified="2018-07-18" version="1">MASMDVDFDDLEAREIDVATSATHPETAQLLSELDRKKLARKIALPTNDAEIRARLRELAEPITLFGEGPADRRDRLRDLIARARLDKGEAMEVEEESEKRGSEDEDEEDEEFYTEGSAALKQARREMAEYSIPRARRRLARQRLDAGVPLARLMDVRKAVFANLQSFTNLGSQIGDTRAISALRFSPDSSMLLTGSWTGHAKLWSVPHCREIRVLKGHKERIGGVAWHPQATLSQSASAVNFATSGADNDIKLWNLENDSSLRTLSGHEGRVCRINFHPSGRYLGSASYDGTWRLWDVERGDELLLQEGHSKEVYAIAFQQDGALVASGGLDAIARVWDLRSGRTALVLSGHSRDILSIDFSPNGYQVATGSNDDTIRIWDLRMHQAIATIPAHKSAVSDLKFFQAPPKAQSYPDCDLPRAFQPLSIFEGAGENGTSAEAASNGAADEKPDFPLSGSFLVSSGFDGFVKVWSADDWQQVRALSNDQSGKVMSVDVSSDARFIASAQFDRNFRLFSHPDTDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B574</accession>
    <name>A0A2S5B574_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="14">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_5222</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="14"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B574"/>
    <dbReference type="STRING" id="741276.A0A2S5B574"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 14 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="16">
        <location>
            <begin position="765"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="641"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY71861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1120" mass="121500" checksum="7FBE7BEA1D6DC184" modified="2018-07-18" version="1">MPKVQPGNPDWVEWVQELVDQAEAIGSKAAQTYKKAANSLRSCPITFQHPEDALQLNGVGPKIVSHLTKKLQEQCEAEGVPMPDRVGPASPRKAQKTAAKPKKRSTKARPSSEDEVDPREARRQRLNNAGAEGADAAAAAALTFNAHPDGHIFNQPLDEDAPGAGTGRGASKGKGKATAASKEPKTREYIPRQNSGAYAILLSLYKNASFDERQTWITKGQVIEDGQEYSSTPFESGTANRGGQIQGGAGFTYSAWGGMKTLITKDLAVSDNKRPAKFALTPAGYALAERLAPLAGIQVHVRLPSSSYGSAGGLPLSSSRNVAAGTAAARAARPLRNADEHAYFPDLGAAFGASTSGPSILRNTAIHVAAPRKRQATPDLFAEREAPAAPAAGADDEDADFQRQMRRALELSRQEAIASSSGAEDFGTGSGGLGLNGRKAAMGMYAAAPPKATEVPVLKNVDSAFGYYYLSEGATHRSFAPKDLRANAELLQTDDVRTLNRDHAEVSQTDDGDLLFRIEYRVAQDLHPIVRGLKKIAPLSRAVPQPGGITKSAYIRERVSNDTAPGFPDKRSLPAVPADKPAFNDPISSLLGGYKAPSKSAKDAMYAPPLNVRLLGGDGAPAAAAPLRGVGNVSDILARFQNGGPSLSSSPRLPPAALNPSPPPPPPPRRPAPVSIEPPVSPKRPRLSASSILAEAPRALGPTSSQNPLQATFESTVTSRKSTNGQPVVVNRHPLDPVRDHVSAAPYTHTPFAPIVWPKGTFQVYLVVDAREGTREAGKRVDFCEKMEREGMRVDGKMMPLGDMIWVARRVDPLTKRPTGADDVVLDAIVERKRLDDLCSSIIDGRYIGQKILRWQFRLKDSGITHRIYLIEKYDVAAQCTVAVHEKFGKQIWTSKSQLRVNDGFYVHESANVADTISYLKKRTQVMCEIYEVGHQDARENLNFQRLLTSFPLQSQDLHIIPDGRIDRSTYLPMQQHLRVTQPATQFLTTYTSFCALNRSDAALTLRTQWASMIQRVSGIGAEKAVQFLGRWETPRAFWDDTKQYEAEVDDENRRLDMDEVEAAVPAGKGKGRAKKVKRRKAEDFVFAELDDGGTRGIKGKLGAKIWELFRAEGKYTVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B592</accession>
    <name>A0A2S5B592_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000064">
        <property type="protein sequence ID" value="POY71949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B592"/>
    <dbReference type="STRING" id="741276.A0A2S5B592"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015776483" description="Post-GPI attachment to proteins factor 3" evidence="9">
        <location>
            <begin position="36"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="58343" checksum="A7E7FE057206202D" modified="2018-07-18" version="1">MPDPIRRTPTRRRRTSPTSWLVCASLLLSATGTHASVGDKSPAYARCTSACEQSRCGPTTASKTTTTQSHYLPPTLDAYPKSSLLWSCRDTCRYACQQYLTDLALSHPLAEDHDPEHTAALEGLPLGEQVQFHGKWPFHRLDLSGLPWFPFGPIRIVDFLLVPRVQEPLSVLFSLANLWAHRRGLDALQKLARQGRMVEGRRLARVYAAYAWSGIAAWIASTVFHTRDVDWTERFDYFAAAGTMLVGLWAGVVRVQGWYAPLSKGKSLAPTQRRAASLLTLLLLGVFLVHCAYLGLRDRFDYTYNMQFNVAVALLTIALWSAWSYRQSRLPTPSNFSRRQLSSYPSARARFRAPHYLSPLGPLIALPLLTSLELLDFAPVGFGTGLRLLDAHALWHLSTVPVVIVWYRFLIKDVRWIDGQGEGGDPNSVLPTAPPGSTLSEAGSTASTGSSGATTTSGAAGGGSWVIDRLEREGRKLGFALGGTGGATTTLTSAATGAGGAAASSAVEPHGGVHARKDSASTDSTADTKAPQVDRRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5C6</accession>
    <name>A0A2S5B5C6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5C6"/>
    <dbReference type="STRING" id="741276.A0A2S5B5C6"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7117" checksum="51EB436848978155" modified="2018-07-18" version="1">MAKSKNHTAHNQTKKAHRNGIKKPKTQRYPSMRGVDPKFRRNARYAAQGTQKAIAAAKKEAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5R9</accession>
    <name>A0A2S5B5R9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5R9"/>
    <dbReference type="STRING" id="741276.A0A2S5B5R9"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="476"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="924"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="725"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="924"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1017" mass="108665" checksum="42F20F4FF9A9E453" modified="2018-07-18" version="1">MANDVSIASTSQLPAPSTLSSVQAAIASLTRRDRLDAVQQQTSLSPSESTRGNTMSIDGQSEDEAGNGKGDAKSTKPKNRRTRNGCLVCRKRKKLCDEQKPACGACSRLSLHCEWEDRVQAALERRQRRIDKMRRKEKEKTGIETAADGDERIRPAASADSGMATEWTSIQVDGESAAYNPSAPNIFPAFPASPAPLPPSSLPLQPFSTSQSALESPTAEATSANSWMPFLGSFAPAGYEPAAAPDPLAWSAGWPSGFGYPPFGQTQPYPLLSYPALEPPLRLPEGHAAADEQRDQILDLDAIARLEDVQTDMVLQAQGYLTQDPEGGASAPAVEGVSPTGSSPPFDLFALLRSPSPVHPFASSAAPGSAAGLSFPLDLSTASSWTAPSQAALLDGPDPRCAIKATPGDAQLATTAGESSADPERGRGRQMQVGQKGLPALVGHAASFLASADWAFTQAYLLSHYTSSLARLVSIASSPSSSGGDSSSGSDRSRSRRGRFSLNRTQPHDSPRPGSSHSRPRDSATARSTRASANLFLSLVPLANRHPYLLHAILAWSAANLAAASSNHGQAQAQGVQPGSPPSQSGGNSVMATLSDQLGHLADEEISAALPELETYAARRKKAATTRAAAATDEEPPKNWEVLLAARLMLTQAAICQGAVDLWRVRLGEAAHIINLVGGVQKCRSPLARQLVKNLLYHDVLSSTSRRDGLLLDYSFLRHHGSMGGTPSTATASGTSPAGASHGGDGDASTPGETDEERRRREAEEDEEDVLDTLMGCAESVFLLVGRITSLAKEKRQALLSSDGSVAEDDLATFSRQIDELRSELEREKERMDAFLIERPDLEPHRYFHEVFRLAALVYLEMLLELPPTSYPILLLVRKMLSLTEVIVSEGLPGLCSMHWPLFLMHLNSTPLISPHHHAAAAVAAPSSSSTSSPAASASGDPPRAASATSTNAMIPAYSDRSRSTALFDAHMHEFTFMNTKRSRALIDEAWLRSEGGRKFVDPDAILDEWKWDLNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5S1</accession>
    <name>A0A2S5B5S1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000059">
        <property type="protein sequence ID" value="POY72085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5S1"/>
    <dbReference type="STRING" id="741276.A0A2S5B5S1"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="430" mass="46915" checksum="9B92C38449F327D7" modified="2018-07-18" version="1">MTREIDCLLLGTGTSGALPSVACLTSAERGCHCCRSTLEGSTDPLGRKNVRRNTSAVLRIRDSATQAAEEKTILIDCGKTFYSGAVEWWPKKNLRQIDALILTHAHADAILGLDDLRGWTLRGAIQRSIPIYLTQATFEEVSKAFPYLTNAGKVTGGGDVPALTWHIFDEDKPFEVAGIEVVPLPVHHGKFFTTSPTPFYCLGFLFDRQLAYLSDVSYIPEVIYDRIASYVSIPAAAAVQPAAPNGTTVANGNANGKQELPRLKALIVDCLRVEPFASHFGIGQAVETARKLGAERNYLVGFGHRTSHRLWLALTRSLSLPPASLPALPSHLTIDPAVPTPRPAHDWQYYSGHSDPTREDEDEFVLHARWATESWLAAAAAAAPEVDGAKDANGARRQADEAVWIRPAVDGMTIRFGGDRETGDDEYEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5W3</accession>
    <name>A0A2S5B5W3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5W3"/>
    <dbReference type="STRING" id="741276.A0A2S5B5W3"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="241"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="422" mass="47749" checksum="D2637881CF1EAAD2" modified="2018-07-18" version="1">MTSKSNWPPALKQFVNETFAKCTDANRQAVETELKQAIYHAFQAGQLWSTDWTNYKLESLNPAKKRKGFVPTTPAANGVSPGLSDEQDRRAKRARRFDQAQGGVAASNGPNSSARMMGRLVQGGVHSYGDFSGASTPDMDAVYDPNVIDWDQYTIVGKNTKLEKPYLRLTSLPDPNTIRPLDILKQTLELLKRKWRDENNYNWVCDQFKSMRQDLLVQRIQNDFTVQVYEIHARIALEKGDFGEFNQCQSRLRHLYRLGLNGHPMEFLGYRILYLLFSRNRAELNTTLAELTPDEYRDHSVSHALGVRLAVTQGNYTKLFRLFLAAPKMGAYVMDAFVPRERVAALVTMCKAYMQIPLSLVTSQLAFDSDQDAHDFLASHNAALYKTPNAPLAERHLDCKAAFAPLNEVMSKMSKADLKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B665</accession>
    <name>A0A2S5B665_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiazole biosynthetic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000056">
        <property type="protein sequence ID" value="POY72201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B665"/>
    <dbReference type="STRING" id="741276.A0A2S5B665"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28964" checksum="1597F2E40582A1F5" modified="2018-07-18" version="1">MASTYTGFKSSVAAAADMNKPTVAQTLTKHADLPISPPSSAGSDVDAAELEKRYTEDYNGQYRFAPIKEHIVSRAMTSRYGKDLYDTAISDVVIVGAGSAGLSAAYSLAKERPDLKITILEAAVAPGGGAWVGGQLMSAMVVRKPAHLFLQEVGVPFEDEGDYVVVKHAALFTSTVLSKVLQVRWSQCRYNGRSARPSCSSRVPATTLHAAALLPRTLTFPCRLRPRPRIDHTVHGRSALVLDCTQARSRLQRFCKPVPVSLGLPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6G0</accession>
    <name>A0A2S5B6G0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6G0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6G0"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCN5-related N-acetyltransferase Rv2170-like" evidence="2">
        <location>
            <begin position="244"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="333" mass="36104" checksum="6D501FA37868FFA0" modified="2018-07-18" version="1">MAASASAVRLYDHSSSPAPLRSLLRTALPLSLPLYSTLSTPGLPTPVWATLSPGAVPENVQDSPPYVILADLGNQLRFFCSTEAKRDRTDDEVKDAAVLVSGALRQYLRQHAGQRDRMSIGAIPDIWRQTVRDTFGVEPFSASEIHYRLLAGLPDTLTNGSTKGASVLPGGIVTTKGRKEDVAEILSNSEVPHPPSYLETRLAHTTVLRSPPAQTPTNAATCTSDPRTAPSDPSTPNGFPPDTILAHCTTHRDGSIGTLHVSPLARRRGLGTLVYLARSHTMRDSEGAEYVFSYVHKENESSNALMRSVGMDKSGYEVWWARIKLPLPDEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6H1</accession>
    <name>A0A2S5B6H1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4688</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B6H1"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="113"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="113"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1394"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2063" mass="225646" checksum="A749C83444FAED3E" modified="2018-07-18" version="1">MSRRYQAATYTVPPLQNRREALHLDPSQLPTYFDSLADISQYDLASIGARTNLKLALYNWALGGVAGGDNAFLQDGDGAVIDAVDDKWTLSAAQSSASSSNSNSSAAPTRTGKPCGHVFKPGESVYRCRDCGVDPTCVLCAVCFRSSGHVEKGHDVTMSVHAGVGAGCCDCGDVEAWKEGCQRDCRYHGPPEAGADEAGRQPDAKGKGKAVDQDEHSGDERVARATARVRETLVAALDWALDVLEHAPDSFTLQSRVEEITGAVPGSPPAPEADEDDGGEARPPPAMTTTTTAAAAFDPTAIGPDSVAAATANVGVGGLTAASVARLLREAAVMNPQLAGPVLADEDGEIILDPNEAQLPPALREILRDLDAAAAQHPEEAGGAEGVEGYDAEGVLLPGTFPGHERFLNGEDDLEDSDAEAHAMRQPLPPPTEGPYATVLWNDERHSFDQVIAQVCRATGSSRQEASDIAVRVDKQGRAIVMICPEPAICLMAARTIRQIGLVTTIRTALDTFREQVAVEICTSFVQDLLRVDVAGERGALGDMIAHVWLDREPGEGAGEKSRFQRWIGVEERLWKIARKTGQEVAVGLVNVSTDVRAELSIQYAEMYTYLVESYLFTDREPENSLIFLGVQLFTTPSVAAMLVERYGIASRILDILYSLFTLQVSPAYNKPEHFILPPDPSKKFVSLVWPHTSKQKRFFQLFSDLEHLLSSPAVQRYVASSTILFEQFTRLFGLFNGLGAQMRAAEVHVEFESDQWVPAFNMVTHVARLARSFGAAFRQADALRYARTLGSALTKVPAPGYEFKFHQVRIGELEYPCVEYDLTKQPVSFHHPQSWFWAELAKHAVGDKLSPGALETIGVEGGLTELLVGEVPPSPPRLTHSVANFLAALEAPVHTVALVSQVRAGLWVRNGFSMKAQHLHYRDYSLRETAWEQDLFFLQTAFVAADPSIVVATLVDRFGLRDLLFKHTIPASAPFEPEQGLSLLDELLGVVIALVSDPTWAAPLAPADTLRRELLHYLALAPTTYSDLLSHVSDRFADDPTIDRILGQIAQFKPPSGSNDQGMYSLLPDLMAEVDINFQHYTRNQRADAEALVKEWEKKRTRSARAIEDIVIVPRPLPVDAARSGPFVALPRAFVSHGMQALIVAALVAGRGVSTEVADGEASIGRTVSSDAVVERALQLCLLAQVEQPEALAAACLEPWSFGSEQHFTLAQLLVDIEEDEQSKGPRAKARYLVDALIERRGVEVASLRKAAPSTEEDKSGVTAEQYLEAKRAAAKARHAAIMQKFQQAQSAFLQKMEGEAGLDDLDGDDEDAAMVESGAEPTMSTSTAPQIDFGSCIVCQEALESTAPFGLLGCIQSSRFIRLTPDDEGEARHTAAPFIEEVLNLPASLDRDMSSSRPYGTASVKANAGDQRTAEDGLAQGFPLSTKAGLHASSCGHMMHLPCFEQYCASAIQRHAAQPDRQHPEELERREFVCPLCKSLGNVILPVESDSTAFVPYSGGFDERPLSEWGQRLADPLELGSLTRLGPDFERRVDKLSTVASVNDPPAAFRPWLAQSSLLTLLPEHFEEAEGRMAGGLLQVVGSLAEEGRLNKPTLTDHLLSYTVATLEVASRGTADPVWEVSQANVHLLQSMTQVLRDLAELMTQSNDSMRVAATSLRQRLGGEFSEGSKYDRLTSLQVNPLSQVIEAAVCAPSAFYHVVSVAFYTHLVSSLVAYYRLAYRVQAFPHAEKESSDDADEASTLAQLRHVFAGNVSPEWSNDDELPVFFARLFAEESSAVAAGLGKHLHAQMTVFLRRVAIIARVLLGAPSEEAIDAFLDDERTEYARLLELLRIPHPSHVLDGLLSRPTSLGGDVDTLGRHVLTLRSRLWAFTRPADELLQRQEITISTFFSSHWPELFPEHPAPYELLGLPKHLDSLLAEILERECQQCGQVPSNPALCLFCGELVCAQMFCCMTDYEDEARGECNEHMWGCGWSVGMYYLVKRNVILTLYSDRGAFITPPYLDSHGEAQMNDRRGRSQFPQSLHRQRYDEVRKIWLTQGIPTYVARKLEATTDHGGWETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6W6</accession>
    <name>A0A2S5B6W6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6W6"/>
    <dbReference type="STRING" id="741276.A0A2S5B6W6"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015608504" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="104"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="135"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="371" mass="39774" checksum="B898E47AEEB89BA7" modified="2018-07-18" version="1">MLATSGITALFALALTATVSAPVNAFEIELTKRDLGLKSADGAVNIQALDDETARLTLKYARNRANWRYHVFGEGSLDATARMAREKRANVGTLALAHPGFAIWTGQVSVGTPAQNLDIYFDTGSSDFTVASTNCPSSSCGTKDRYNVAASTSAVQTSKFVRTNFVDGTSSQGPVVQDVVSIAGTVANQQDVVAATSLSTSVAKIASDGMGLAYPALSSAYSLSYMFNLYNQGTYLYPYFSMRLSNSKPSSLLLGSYNRIYLGTQLRWFPVTPQAGTSYRTYWQIGGSAPLVNGQQAITTRVNHILDSGTTFIVAPPTAAAEFWSNVPGSQVYNSQYWTYASQMQLLAPSVYVIHDVGGNRIGLSTPPAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B711</accession>
    <name>A0A2S5B711_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B711"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="59" mass="6897" checksum="C6DC410AC4CC2D98" modified="2018-07-18" version="1">MPSFNMLQPALTDKERKVLKEGWTDWTNFMESHGLKPYEDDDVKEAKQILEQIAANDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7I1</accession>
    <name>A0A2S5B7I1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7I1"/>
    <dbReference type="STRING" id="741276.A0A2S5B7I1"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="100"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="386" mass="41916" checksum="75C5BBBF980CAE9C" modified="2018-07-18" version="1">MSVRAVTNLARSSITLASTRRLGVTSTLSLCNFTRTTTNTLQSLVAVHKKPQHSQQRRTMATTTSATTTTAPVPFRTHSPQPDAAPSTPLTHVFFHVPTSTWTYLVVDPSTRKAAAVDSVLDFDPQSNSVSTETADGLLAFARQQRIEIVKILETHAHADHLTGAAYLQHQLAAAAAPGTTGAVVPIGAYSSIRETQAHFAKLYDVPMTELEGAFDELYDEGSEIEIGDLKGQVWHLPGHTECSAGYVFGDAVYTGDSVLLPSIGSARVDFPAGSASRLFASSQRLLSLPPHVRLFSGHHYAASPTFEGGNRCSATVGEQRELNKHFKEGVASQEFVRMREERDRELNEPRLLHQSLQVNIRAGRLPKGQDGRSYLRLPIKAPAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Q2</accession>
    <name>A0A2S5B7Q2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Q2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="301" mass="31912" checksum="4C7A2A1F5EBF92E4" modified="2018-07-18" version="1">MPEPAQSEPATSVSPSDVAGEELATQESASHSPAQASPTETNAASEPESTGLVMSELSAVEPIKSSHLSAPLASTSGEAAHGHQASSPKSPATLEPLATGSLTELPMFAPFGSDYCFPPKPSPKRAEGSLAQNAPGRRPDAQGSLGKPAATSESESFASSGATMPLNDEYKDSEEAATPDSQSSTRRNSTSTVVPPKSASERQPRCKHGVPYATTCQCDQTCEAIAHVKKGEPVPPPPLPKLYVPRAFAELRRCPSCDRQFESLGQTRTEAERLAWVIEEHWPCLVHLMLTRRIEPAFADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7X8</accession>
    <name>A0A2S5B7X8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7X8"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="678" mass="74541" checksum="8393C76FCF8ECCA2" modified="2018-07-18" version="1">MPFSYGAEDDPGPPRAGPSRDRDAELARALSSRPPRRAEANKATVRMAALREETMKPLVFDDDEDAIAVASTQWPDSEADDDDDAGETEDETNDVDESDADEYVEERPTKRRKPAQRKPARAAKARKPNKGKGSKGSLVNSQMARPRARLNSGSTSAATGRGKAASRPQKELESQDSPDARVEAGEATGADPAAEDEVDQLASESDRELARQARRARKKGKGRGPGEGPEKYRSRARGFGRDKPELFKLAVETINAYQTAKTALPLPLPEGRLLRQAPFTQLYDNYHLPQLSALDRGNWGTSWHGLLDKAEEEEYDVKKTFKLVVVVKKATELGVLPSAEEIANAPGYRNHALRRAQRMGPLKELKSATATMKKAPNSTSLPVFGKILETFEKHSSVFVQIRAGAYAKKGGQTAIEIVPPSSLRSFGVTTSGYRIPDTVGPTEDFQAIRDLFPSDAELAKREKDKGSALPAIDAQLVPPRSWRLSSDKLHDRQSFIGPDEAAHDDTDQAGAAEEGAMTPAEQVLQRAVLNSVDSADNEQLDSHTFALPILPDSWTLTCDVGTLVLSGLDPSIEKRFTDIYERIEQVVYTAKKSKRAWYWVQEEKDKWDLVYAPKRHLLGRRYLRLDVGSDDEDDEPDEPNDDEAAEGPADDFADETSDESGEADDDDDDDDSDAQTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B851</accession>
    <name>A0A2S5B851_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B851"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="403" mass="44200" checksum="AE89421B8C77D271" modified="2018-07-18" version="1">MQRRHQPAELRVHAGLRPSDMTRKVTICGATGGQGAAMALIMHFLRGQHTEHPQFDLTKIVFSGLNALGLIKNASTAAHQNRRNPSDLRESFWTLLTLPSREVPITVIYRGDDEEDGDQIFQTLMHSIAVNTAQWAAANGVTTAGNHATGEVRLPFVVPKATGPQQRESQPRSFYWEGPWRYLYIGQVVFNPTAMAAVQRAVTVYSHSAPTPTGTIPSPPPPAAAPPLITEHVKVQNLALVLFDAVRLSSSWHGSSDDEISQHLLIIFLARDLYLEYEYPTNSAHGLGGFLLGADDLVDGWSDEEDPLDDTGINELAHCGHRLHEALSDPELMEQWARDFANKYTGDGQLHVPGGQTAAVHAQVANECRATLSWTRSVLLGGIAHALRLHRHALAQRIAHASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8E8</accession>
    <name>A0A2S5B8E8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8E8"/>
    <dbReference type="STRING" id="741276.A0A2S5B8E8"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="65"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="377" mass="41061" checksum="916DEFCF7DE6FDD9" modified="2018-07-18" version="1">MAKGQGNRSLSPLYLHTDTLTASQFISNMATSLPQGAPHLVSTKRHDLYDAISPTSALKNAADGLSVLVTGSGRGVGRAEALAFAQAGAKKVVLTSRSRTELDETKELIDKETAGGDCEVIVCEADLCDPDSVEKLFEAAGPVDVLVNNAGYLEPCVPIRDSNPSDWKRTLDVNHYGTYLPTRAFLRAAHARSQGNASELAGKLTVINTSSTGSMGTRPGFSCYQPQVALQNRLDWHARGSDQVLTVACTTRSKSFINRFTEFIHFEEPDVRTFAMHPGGVMTKLARDSMPLDTHSFLTDTPELAAGFAVWLATSKESDFLRGRYVSATWDVTELLGKRDEILEKDLLWTRVVGQEQASLQRAHIRAPTECLCESGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8J1</accession>
    <name>A0A2S5B8J1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8J1"/>
    <dbReference type="STRING" id="741276.A0A2S5B8J1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="106"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="400"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="444"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="545"/>
            <end position="547"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="645" mass="73212" checksum="700C794FC5A18DC6" modified="2018-07-18" version="1">MPPAKRTRSSASAKAPPSPPKKARTNGTSKSKSPEKETKPRIKKEEDEDDDGHDPRFRSVSTAAAEQIANEHFPEQMEETPIAKLYNAMRALSEVKRDTKPNKDGVVVYWSRNKDLRLVDNTALSYASALAQDLGVPLLALHIFSPGDYAAHDRGPRRIDFQLRQLAYLKVEFAKHHIPLFTITQDRKKRKDIPRMLCEKLEEWGAVGLFANVEYEVDELRRDIEILERTKEARQSGKGFGGQVEFFKDFCVVSPGELLTKQGKPYSVYSPWQRNWADHVNSNLQDYVSQQNGPLLANPDSAKSHPILKPMFDHEIPTEIEGFELEGGDEEAKTMRHIWPVGDGITESIMRRFTHNKMREAKFFEPPLEGEDEEEVDDPKKSSKIGKYQEGRNRVDWDGTSHISAYLAAGLISPREPIRIAYKLAGSRELPAGRDSGIGMWIQEIGWRDFYQHVLCAWPRVCMTKPFNLNYDGTIEWATDDDGAKLQAWKDGKTGFPIVDAAMRSLKKQGYMHNRCRMIVASFLSKDLLIDWREGEKYFSQNLVDADLGSNNGGWQWAASTGTDPQPYFRIFNPLSQAEKIDPNGDYVRYWVPELRSLKGKSVHNPAATLSEKKIKELGYVMPIVDHAKARVKAIDSYKEASARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8L0</accession>
    <name>A0A2S5B8L0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UV-endonuclease UvdE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000041">
        <property type="protein sequence ID" value="POY73113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8L0"/>
    <dbReference type="STRING" id="741276.A0A2S5B8L0"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="74866" checksum="B418F9C5D32F5FCF" modified="2018-07-18" version="1">MAPDVEFPGESAAPRNDVANLSDRGRREERPPEPAAYDTRAEQQAREMQTIVANAVRHTTTQVTAAAVVNGTARSTRPSRSAAVAARQLASAAIKNDDAAAHERRSRSPSSSLSPLPATPSPPPPAAAAAARLDSADERMGDTTDGGSVQVTPAKRGASSPVGTTEGETTAGDGDSAEDADVKKPAPKKKRTRKPKEPEVYVIPDVERLETTFKGRLGYACLNTILRKQKPPVFCSRTCRIDTIEKEDKGMPYLKELGRQNVLDLIKMIEWTAAHHIYFLRVSSELFPFASHPDYQYSLEYAQEELTLAGETARRLGVRLTSHPGQFCNLCSPRQVVVENAYRDLEYHNEFFTRMGMGADTVMIIHGGGVHGDKPASLDRFRKHYQELSDGVKARLVLENDEFSYSVDDLLPLCEELNIPLVFDYHHHSIFPTERPIEELMPRILAIWEKKGIRPKFHLSEPRKGAVTPMERRAHADRCQRLPSPLPDDIDLMIEAKDKEQAVFHLYRIYNLAPTIYEDLRPPAEEETLRTAGRKSHKPKSAGKKGKKGQEEGEEDVKDESEVKLEEQAIQDGVAPLPEGKDAEGQAYSPPVDPAKVQELAEQEEKSKPKKRAAARSKKAKNVEADMSPVKAEGEEDDDAVAAPKAKRQRRSPAKKAAVIATDEVADMPAVPTAEAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8W7</accession>
    <name>A0A2S5B8W7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B8W7"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="880"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1315"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="757"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="763"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1849" mass="205248" checksum="5C5D9AE917B25695" modified="2018-07-18" version="1">MASDSNAAQDAAISTHTNGDARVGDSLSPAAALNQLDQTWFATRAQWMDVLIYSGQELFVLDGDALVQFVLDDNLLAFAKDGDPSLQLLHATWLLERTVDDLLKKDTAFEIVFFDSLAHSTYHTGASDYVVAARRLARSILLRRANLPQTRLHRFDSLEDEKWQVWYQHKRPMYVLGHDGGIKTHEGQLEAERIILQRQHLYDTVHQSLPYVLLQAAELTDTKINSYFYDVVRGTVPPLPSNITAAVSDARSALDKALPGLPKVDQAPASTSVEDILSAAGSTFLLTSDASAQDAALLYLYLSHVLLLPTVPLRSRAHRIPTPVKDVMAALEPFLARVYSSLTAALEALPESERMNPLADFDLDGRVFFLLLTEVLNGDVSPASISDFLGPDVASRLSSVWTKVSGAPEPDFAALRSNLPKQTGELAAEPEKITEPSVLPYSSSIFTEHLSSVNVTVAADSTLATLPNKLAEESVFSDERGWSNPKPALPTHLGGAPPPVLDYRAKKKRDRKEQRFMAQMQKSAASLTGALGGALKQQAIPAVGKRSASAIKEKAALAAKASRPASGASTPALASGAVTPTGSEAGRDANTTGGRGSKRDKTKVLSSREKLIAENALKKVQEEGKENYKWWVERLEDLKTLALPGQISQLDAYLRNKRAQDPWLGTEMLVKRMDLELRKWIADDRREAEDVKDAYRVYLARTASPLLQKYLRAQQEGSQAVMINEKQGRAITTMLFCLGLECLIPEEIVKKQVTFGGSAAEEGDSKKDKKSKKDEDDGKKKKGGAKPGSKAAQASKKDATASASSKTSKAEKDERSKLTFHFCSLIDKDEGEVMYEWMEIDENPLEWQLRCMGEYMARELDSQPDPRVNFEPDAWQRDVLDNIDADKSMLIVAPTSSGKTFISFAAMERVLRESDDGVVVYVAPSKALVNQVAAECFARFSKDVAGQALWAVHTGDYRVNNPQNCQILVTVPQVFSEMLLNPALASVWTPRIRRVIVDEIHAVAEEGSGMWEQVLLMNPAPIIGLSATVGAPERFSAWLQSVEERCGREYALVIHKHRFNALRKFAYAPKLQSFPKTPIGPLDEYRARPQLFSPVHPIAALGLGDPELPEDLSLEPRDCLALWQAMSSADESLDPTLKPRKFFAATPTIAIKHTIEYERRLKTILLEWRNEPEYAKPTSRFSKTVEYLEKPLREALGVNEKMIENATEDEFNSLFTPLLADLNAQNQLPAILFNFSRDHCESLAKRISKDLEVAESQWRMNSPTFRERLARAKAAEKAAAKKAKAVESATVNRKQEEEAARMGVVEEIQTFDPEEPSEEFTFVGKGISHLEFKKDVDELLFLDMDPWIINALRRGVGVHHSGMPRRYRVLVENLYRRGVLRVVISTQTLALGINAPARTAVFAGDSLELNPLNFRQCAGRAGRRGFDLVGNVLFVGVRLDRIQRLLLSKLPKLGGTFPLTTTLVLRLNNLIHGSNAAELPKMAVETLLDLPQLAVSHGSVSSNREQTRHFTRFAIEYLRRCGLLEEDGTPKTLYGVTSVLYPEEPSNFALAALLRSGELHNVAAEIDTDPDNALRQVLLVLSWLFARVHRRKQSPDTLRVTRNSNWAIVLPPLPPKIRAVLDSHHRAVTSIFATYAKEYAEQNQDKLGAEDVLPLSERKAAVSESADGAFASKLRQSELAFESRSPFAATSGHGDDFATTMDLAKTARAGVMLYQHAVPELASPPFDSTEHDLDAFVLDFMKHGSLEVLVRESSLARGQVWFALQEFDRALGAIHAAFKTLYDRKNDGYEEDVDVDDARDAKEDRGYEDENVRDRLVRPQGCTDQDWALYRCIDNLYNDFHARFIAIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Y1</accession>
    <name>A0A2S5B8Y1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Y1"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Y1"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="259" mass="29200" checksum="C1D596241A619E2F" modified="2018-07-18" version="1">MPTRAQLEGALARYSEALRLRSTASKSSKDLLELDRWYRGELRTTVAERRTRSTKKGAADWLTKAELVRLMDWKLARGKWRPRLQQMVASNPDSAVREAVSAASAATDRESALKELSKLKAVGPATASAILALWYPEDEPFMSDEGIDFAAALDKGDKGKKAKRDYTVKAWREYRQELQTRLKKEEQWESMEQLEMAIWAWATLRKYSPEGETAADVEATAEMATEKEADGDASEKAKRRGAANSEEVAKNPSKKRKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9H0</accession>
    <name>A0A2S5B9H0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9H0"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="148" mass="16984" checksum="D88E7A3252ED3811" modified="2018-07-18" version="1">MNLDLYLIELDVNNDPVFETMPQDDTLMRSLLQLPQQPAVVRIRLRGFTLPHVIHNRTAAKEAFGIERGINQTDYRHISALSHNVLGDMVSLFVRMEVCEARRRESLDALALPREDDPWLTAAELGQVPQQILWDPVRTRPGRASFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9W5</accession>
    <name>A0A2S5B9W5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9W5"/>
    <dbReference type="STRING" id="741276.A0A2S5B9W5"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="70"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="361" mass="39642" checksum="7A7936EB4FED7338" modified="2018-07-18" version="1">MSNGDVTMAEASTNGKVDKGKGKAGDIGLAELITSDNLPWVEKYRPATLDDVVAHKDIIATIDQFISKNRVPHLLFYGPPGTGKTSTILAVARKLYGTGALLRNNCLELNASDDRGIDVVREQIKNFASTRMQGGGGTAGFKLIILDEADMMTSAAQSALRRVIEQYTKNVRFCIICNYVNKIIPAVQSRCTRFRFAPLPQIEVEKRLNHVIEQEKVSLSEDGRRALLKLSRGDMRRALNVLQACHAAYELTTETEVYQCTGNPEPADIEEIMKSMMNDSFEAAYQRVSAMKAEKGLALQDIIQGIYEFAMDVGFSAPTRVYFLDQLSQVEHRLSTGGSEKLQLTALLGATKNAVELSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAQ0</accession>
    <name>A0A2S5BAQ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000034">
        <property type="protein sequence ID" value="POY73843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAQ0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="407" mass="45534" checksum="E8C18DB6A7E322E0" modified="2018-07-18" version="1">MSGRQEPALSPAYAHVTTPSDLWERTGRVTLCGPTGQLHALAILESFALDFEAAELPPEVRAQFGPACLLFHGLCALAAFKTAAAAHFSDEPPASTLRESLWYLLELRSDEAPIEALYYGVPADFGADFLDAADRRTRSWAARQGQVWSTTDREWAIRLPRLVPQDRRLDPSILDWCAPWINHYVKVLSKPIRPTETPDFHAAVRLHVSLPPMTGSHVLSCVTDELDPAMPHAEAVPVSVCSLAHNFLYAVMHLSTCVGRQGSFRARDLLHIMLVRDLVETYGHHHAAFRLDKLATLAALVYDYRQLVRTQSRLARALDDENTITAWCGVFVDEYCGGPATTELGGAGSQARFRVPAARTPGFRDSLKRECLETLAWLRRRLFLLTADRVVDRFQARERDRTPTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAW4</accession>
    <name>A0A2S5BAW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BAW4"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="836"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="899"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1174"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1443"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1595"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1667"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1751"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="837"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="960"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1223"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1292"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1316"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1362"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1410"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1617"/>
            <end position="1628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1826" mass="195320" checksum="34F678F917EF6819" modified="2018-07-18" version="1">MTSQAHIPTYHYSQMTWTEPPEPLLGPSNLATSPTPFDPLPPPVPPTIGVATTIENPLYLSIDSGVRRVKACVLDKDLKVVWTDQVELDTDLAKYGTRDGVYTCGDSVTCPSIVRLHALDLVLTKISRDCPDPTLLSRVVCVSGAGQPNALHYLAPNFLHTLRAMPLSATLSLPELFTPIPPSEPVFSVYEPTTDGDATTNDCIQALEQRFGQEQYDTSTEPEYTGVGAVPRSRRNSNVLDRSRDELARRTGGTPCLRSAVAQLMQTLRSDELRREESTKRSKKDKPLLDRTERIVLESGLLASVFLGRIAPMDESDACTTGMLNALTVEWDQDILEFVASQGGANGDRLEAVLGKVGSDGGKALGTISMYFVDRFGFSPDCLVSPFIGAEASLSLVYPLSRSNGDVLVSLSGVAETDSLIASVPDGQYVPSQDWAMIRNPARASWQPEADDAVTQQRSEDEDPAFLAVVQNRDAGTGRMLVREIYCNSRWDVFQHLASITPHGGTLGVDEKYYAYFFPHREIKPAQAVVRFVAGARVREFTDRKVNPRLLIESQALLLRVGLGRLLRSMQPPHEKAQDGVRPFDAAGFAPLSPASHPKRVIVVGGAAVNSPFVFILSSVFGAPAYTPAPLGSTESSHDKPSTTFGQAGKPSAVALGAAYKAAWTYERETTKNRIGFQRFLRRALEAVPTQTTAEQKRSKHESKRSITSYAGTLATSSSVSGPPPSLLSLGGPNLSHVSTASLLQAPGPGQGASNGGAKTFKLAYGVRDEYVLADEADQLSRLGPNPPGLELVAIPDADEHKYYASMIPEHVRLKRCALSGGPSEAWDDDFFFQQPSTASSSRASSSKPALSEESPPLRKHASTSASTTTTRTLKPASLAHNRPSTLSLASIASSAWTTGSDHDATIQPSTSQATPRAPTVRARTGTPSTVRASPASNKTPRSRLPVRSAVPPVPPLPRSASQSTVEDHNSMTTPSLTEDSLTTGEDDDELATETDGSGTEVAMAMPDVAAWSRTGKSRWSFGRRASQKHPVEEGRVTSHPVDLASPVRSKHSSFTSTSSGQSTDRGHHRISLHLASLRPRDSPTVPVPPTPTSIASWREYAGTTTEDDETTGSDEPVSRPESRHVSRSESRHVSSTRPTSPVESILGGDKSRWNSSQVSFASTASAFALRDPVEPTAEALNNRKRKLVKKRPGSQSLEPESLSALGLAPGVGTSERPLLAPSIFSTSSGGSSQTARESRMRPMPSTCAPPSRLPTSSTARTPRPRSVTTPARAAPSPSTVQVDQDWLGVVPFPPSPRQSTDQPPPSPKPIRLVRKSSSTRTRPPVSNSRSQTSLGSTIANFLSRSTSAAPLSGKRAPSPAPSAKSTKSSKSMLFRRSSRKLRVDEPDVSPPATGTVSRRRFSVARPSPHEPVPAVPALPPAAQIPRSGSAFSFLSRSRRLSRVVKPVDAPPSPTKAAPQGRAPTAARDPSTQDSVRRRPPVTRPLGAKHRPSASLSSIMPLRPVSPMPAVAVTPDFGDVAGEVGSLRRNSLGDLRIPLRITTAQKKIEEDLERVKQFAQAIEELKSLRSRFEAVSSANPSAGSCWEQAQVLVDLGDGKPPTDTASPSAASRHGSIRSRPSPTASRSSLLYGRTRKQSASSIESDFSIAARQRDMLRGVLANANKGASLPVRSAPTPRPALSVLTGRQSDPVVSRPTPKEIPLSPSRRASRQTVLGIRDLLARLRTKATGELAASITESVVPQRSVSDSAARLSGLAHSGRRPSAGSGESDEDWDRELGASQEAAVGDVALDGKLALTPEAMPQLLAKAAELRLACEQDLARLPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAY5</accession>
    <name>A0A2S5BAY5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAY5"/>
    <dbReference type="STRING" id="741276.A0A2S5BAY5"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="473" mass="50884" checksum="AD87C21981E4B17F" modified="2018-07-18" version="1">MALHLAAHTLSDEPRSPITNVHLNADASLFGSSTTEGWVIYSTHPLQVLARKDLPDASLSICLPLERTNLVFLVGGPPSPLYAPNKVILYDVQADTAVAEVEFSEQVRGLAARRDRLVVALRRRVVLFVLGQGQTGIWREGTYQTADNPKGLVAIASDAGSSILAFPGRQSGHVQLVKLPPLDRSTPPLPPPPSHDPNAGPHPAVSVIIAHSSGLAALSTTPDGRFLATASRQGTLVRIWDTKTSHLIKELRRGTDSAEIFSLALRADGGAVAVSSDKGTVHVWDLKRKKADREHGQGSDSGSSTPRQRQMSILKPYLPKYFSSEWSHSQFRLPAPAPAASRLPFSLSNPTNFPSQAFTSSTSANAAPTIEDDICTCAWINPTEVEGDGLPSQTGELAGSQLVAITRSGGWFRVAFDVEAESSEDRKGKGRAHETVADRSRTAPREGAIGLDKESTSDCRVAEYQRYGQKDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB39</accession>
    <name>A0A2S5BB39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY73977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB39"/>
    <dbReference type="STRING" id="741276.A0A2S5BB39"/>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="723" mass="74978" checksum="5096E85F2FCAC0F8" modified="2018-07-18" version="1">MRGRQQPPPPLTVPLSAGSVPTTTTTTTAASHDYQPYAYPQQARGPAPVYGGGGLGGSRQAPGHELPVPPPQRELVGLPQHAMSIGGAGNRYADANDGRSPRNPSALPYSNGSGGPNGSHASPIVASPRTVPPPQGAGPSMHALPHPHGQIAPPARTIPSAASMRPLSALGGATATAAAAAAAAASSASPASQHQQPQHLQQSVSPFPQYASNYPRPSVSGPPPQARAAARHSLAPQPNTLLAAHVAVNGTGPITATSAPSGPAIARLAAFNEALQLALEHALPLDALRSVVADHFTDTGVVKIGLIDTMAQMTKVFGARPSQSVDRTARRTEPQKLPAEIPSSAFPRFMNINHLLGAVSTSFNPIVVREFRLTTPDPSGPRSPPAHASSPSAAFPVHIGYLLRSEDAMWCSRYGDGARVDVRGSLTVHLMFKDLGNGAAGLRIESLEFNARGFEESVPRSTIADIERALVAAAADAAMQSSPTKSVATLDDSVGKDGDEGAPLRRRTSKTQTRGMNTRRRSAATKSEQDVADDDDRSTLDDAGSRDAKTTPSLQDRQLDLVNLVRARVAPSPVGSFGVTEMGMRCLEIAESVAQLQNLIAFSIDTGGGPFESLARYADLHRSGAFAPAPPFPPGAGAGPGLVQNGYHGEYSGPGPMQQTFAAHPGLGGDIGGGLAEPIGLKRPAPNTPTIPTVLEQMDRDLPSPQKMPRAVSNAPRGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB86</accession>
    <name>A0A2S5BB86_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB86"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28149" checksum="CF07F0DEA2E4F5F7" modified="2018-07-18" version="1">MDGELPRLDLTGRPLRRRVSSYARYGCIGPGGAIYCYHDTWPRRPAALQRCTNDINGNFGRYYWVCSHPTEDCRSFAWDDYIRPGQNRFHGGANFLGGPAHHERDNRNDHYAAHLFGGDGGDGGGGGGRALHEAGGGDRLDGQVVVEQGGSPAREGTRRHWQDHSPVKPKPYDKPKPVARNAPPTPSGSSPAGSPGKGKDWHSTPKKRGGGPPRGEPRDSSSSGIEAVLDYCDSLERAGVRPDNEYELSRLLNELLDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBJ0</accession>
    <name>A0A2S5BBJ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBJ0"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="412"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="661" mass="75141" checksum="C0E458EA870E6FB7" modified="2018-07-18" version="1">MTDSHRRRTSAVRISVGGLDEDELSALSPFSFVGTPKSTQPLFEKYHDDSAYSSKAPSPYLGAPPSPQLAWKAPPRKRATKSLLRLGRRLLALGVAGYLVYVLVGSGNASDSSSFTRLKRFMGRGAPIVRKELRTDHTYAYGTPLPNESGAYDEHPVHGLIREAKQEWAAKQARQSTSYYDAVREYQRRNGRDPPPGFKEWYRWAKEHNVQLIDEFDLINRQIEPFLALRPSTLRQRITENEDLNSWGANYGMIYIGDGELEIAGAKWRPPVPEGFVELMKPLAHLLPNVTVPLHLHDGAASAQSYTALEAYRQAAREGYWIEEEKIKVNGDITLSRNAWHCDPNSPYRRLIAGLGAQTPPPGPAFIRDHRRAMSYCVAPHNLELHGANAVGPNIGTLRPSFTLSSMEHQNELLWPSTIQYDLNPQNESSFREKANRLLWRGSPDGVAVDPNYNWRQSHRFRLLTLLNSGDGEPRTVRETRLDAAGKEYQVDTEHSLALLNARYSNVRATGVPVQCWTDLCEEVRRMLKFVPKLSLEEMADNRYVMDVDGNAYSARFRAHLASNQVPFKSTVFPEWYEGRIQAWVHYVPVRVDYSDLYNLLAFFDGGVDEERTGNHDDLAEEIATAGAEWASQNWRLEDMQAYVYRLLLEWARVMDPKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBM1</accession>
    <name>A0A2S5BBM1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glycine hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2741</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBM1"/>
    <dbReference type="STRING" id="741276.A0A2S5BBM1"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="50"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="503" mass="55141" checksum="51CB3AD0CB943886" modified="2018-07-18" version="1">MLRSASRSLAQAPRLAPRLITRSYRPSASTMSIPRIPIPSDFNKDLYTPLAEADPEVQALVDRETYRQFRGLELIASENLTSLAVMEANGSMFTNKYSEGLPGARYYGGNEVVDELEVLCQKRALEAFHLDEKVWGVNVQPYSGSTANFAAFTALIQPQDRIMGLGLADGGHLTHGAYTPKRKISASSIYFQSLPYQVDPSSGLIDYDALEKNAILFKPRILICGASAYPRDWDFARLRKIADINGSYLMMDMAHISGLVAAQVSNDPFELCDIVCTTTHKTLRGPRAGLIFFRKDKESDVEKRINDAVFPACQGGPHNNTIAGIAVALKQAATPAFKEYAVQIVKNTKTIAAELLKHDYKLQTEGSDNHLVLWDLRPLGLTGSKIEKICDIAHITLNKNSVPGDKSATVPGGVRIGTNALTSRSMYEPEMVKVADFLHRAVQIGLQAQKEAGSKLLKDFVQKLEGEGEAAKALKQLTSDVHQFAEAYPLPGVADSSTIKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBP0</accession>
    <name>A0A2S5BBP0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytoskeleton assembly control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBP0"/>
    <dbReference type="STRING" id="741276.A0A2S5BBP0"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="40"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="853"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="444"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1064"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1097" mass="124680" checksum="0C2CD03804030079" modified="2018-07-18" version="1">MFSRNRSGSSAAADYVDRDTDDYDARPSKNQSHNPTRPVDKEKAEAELQVALKKATNPDETAPKQKHVRTQGIQQATGRTDLEAIVYTWDYRTSSSIWAALRVLPVMSDEIQTFKALITVHKVLQEGHPVTLKEAQHQTSWLETCARTMGNDSTRGYGSLIRAYVKLILAKLRFHRHHTAFNGLFEYEEYIALKGIDDPNEGFETIMDLMNLQDDIDSFQKLIFAHFRGSANNECRISALVPQVKESYGIYRFIISMLRAMYRRTESMDALDPLKERYDHQHFSLRKFYYECSNLRYLTSLINVPKLPQEPPSLIDSDDQPDLPRRPPSQQQQQAPPPRAPSPSAGVDIEAQRKALEEYERKQAALVAQREAEARRAKEEQERQEREFAEQQRLQAQREREAQEALERQLREQQLMGMNQGRIAELEREILGLRGQWERDQMMLERYDARVKALEGELANVSVTIQQQLASKDNMLQQLQDQVNLWRNKYEALAKLYSQLRNEHLEMLGKYKQMQLKANSAQEAIDKMERMERDVKAKNLELADMIRERDRARYDLDRLKGTQKEEVERLKRDLRFAEERFEDATRNKGQEVSTVMSKFNRQIDELENSLRNKQDRIDELLSRLDAQNGEAERIREEKDQEIAIMQEGMDDTIRQLSEMQVAQGVSDEAVNAQIDTLVLDQEKKFNDIIDSILQSCAHKVDDALYELESPMHDGNQNSTPEYTLSMIEKATTSATEFAMVFNLFLSRDKGGEHVEVIKTANAFAQAIAEVLTNAKGLSGIAPDDTAIDNLVRIGKVPGDAAVKFFNAVQSYRLQGAQPEARKEVVIRNNMDVRNALQKLTSTVEGLKPKAGANLAQSNGDLGNLVETEMQAAAKAIEAATQRLQALMSRPKDSRFSATDLQVHDAILASALAITNAIGRLIKAATDSQEEIVAQGKGSSSSTAFYKRNHRWTEGLISAAKAVARATTFLIETADGVITGTKTLEQLIVASNEVASATAQLVQASRVKSELMSRTQEQLELAAKAVTDACKALVRQVKAITEEQMKRQDDFDPDAMNAHEFKLREMEVQVEIVTLEKNLQDARRRLGIYRRSHYHNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBW4</accession>
    <name>A0A2S5BBW4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBW4"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24953" checksum="871DBB6CBAE30DEF" modified="2018-07-18" version="1">MCADKAATCIISTHFCSTAHQQLVWPFHRQFCRENAHPFRLPPFSQEEADLTYAWYTSEPYKGAPVGYKEEVHAAVNFDPENTEDIKRKLASLVGQEASLAPTAEDSAPGVPAGAIRKIRAANARQSKSPQVHASKQLTWLFVLYQLYASLTGTSGLSFPTDTIWFSLFQHRLAAYAFLRVKLMSAPLRSATTGNPVIDYSELTASSEYYRKAQSAVAAFLRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCE3</accession>
    <name>A0A2S5BCE3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar protein sorting-associated protein 54 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2643</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCE3"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="883"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1130"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1398"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1180"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1287"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1300"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1327"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1486"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1522"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1541"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1621"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1692"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1713"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1733"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1783"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1815"/>
            <end position="1825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1825" mass="191906" checksum="0FEDFBB413D5AED4" modified="2018-07-18" version="1">MALPRDLGSASGANSSRLSLASDAPSRASADSSAANTTRHAIQVPPELQQRVQAAQARYQQFAAIHAVLADPKPNSSLLPTLPVLPSASSYLPSPLSSLSTTFTSAGTLPRSAIPSGKSVAQRRSQAPPIQVSELRKVPKTEFDDYLAEIRDEYDRWQKEVRAAAIEAESAEREGRAPDGRTKNRDEVLPPLDDIPRIFFDSTFNLSNPRTFDLVTERIQLTPNASPNLSKLAAAFEPASARNDDSRTSFEHLPGLGPDTLQDLAADEVLQDKLSHYTAVIESHLVREIGLRSSSFFAALSNLQSLHQQGQDALGRISELQKTLGTEQGGVGSTAKHGLQILQAQARRRGLERIEESVCAVDEIWTAVEGVKDLVENGEWDGALEVSEQIEAAYYASASSASAGKSANGDHRPPLHHPASSSGSLAATGRRAQSRQQINLTKLRALASLPSKLALLRAQIAKSLEGELVTVLEHELDTGIDEYVRFAKTGKRWKGEERDTGSSVTAAGHTLAAVPEEEGEDQDATTADSGPAQRAEERIRDRIRPVVRALVRADGMDSAITAWRESVLREIRALVREHLPTAEAPALEDDDSFAQAAIRSVSKQSVDLGSISEKSLSLAKKLRALSHADFLTLARSTYLGLLACIELVDLQARILSAEWQDNRKLEAERRSRRKGVASSAGLASPTPSGDRLDVPPSGASPSSTNGSTAFDAKSSTSEDSATLATEITDVVHAVAELANVRFSKVIGVRTEVHAQLALADFVEIFDTSWEFVVQCERICQRMIVGLRGAMVAQAKTFLQQFHQRNITENARVVEEEQWGAVEVGPNIQACVALVVQIATNDPPALLIGHRSGSANGGASTGGAAGADIDLPAGPAKQIDIEGKQFFAVSAGLTTIVALMEYLKVLVNVPMLTTDVMSKLIEFMKVFNSRTCQVVLGAGAMRSAGLKNITAKHLALASQALSIMVSLIPYIREGVRRHLNPKQAVMLTEFDKLKRDYQEHQHEIHAKLIAIMSDRLHVHSRTLEAIDWEAAPSQEGAPNGYMEALVKEHTTLHKVLSRFLQPETLQHIMDQVFVALDAKLTEVFAKVEFKSQRAQDRMLVDVRYLSDKLGSLKGLEGQGPGKNIETLVASKSVPRPASSVQPPPSPKIEAPARSSSIPGAKASVAPPVISSVDTGTSPPTAAAPPAPPTEAPPAPPTEAPPAPPTEAPPAPPTGAPDAAPSSVAEQGLAPAPTLPESSDAPVDASRPVEAIEPSPAPASSAEAPTSEAPPTPLSSANPPATQTKKRKTLAERLVESMSRKASAQATSGSGESSSPRTSTDLMRAEGEQAQSDPPQESANAVAGQTESVRAPEILQEGLDTPTLEKTLALEVPDTPIPLPTPTAEELDAVERDMLASVAMSSEDAEMKVPAADAEVEEVPGSKEPTLPDMARIRPDGTGAHPGQTGDSPKTADLTIVEEEEPQAPGDGEAAGGPRTAVPSPTDAPDEPVSNAGASASVPASPPAASLSPSASQPAGLDDRLVSADDSPAPVADSAEGVSGPCEGHERIAIDHQREDTAQPQLSEPSLAIEASATADDFEPEQSHVPGNVVTETAAADVPEHGSEAGISGAVASAPPPSIVVEQPRDDAPAIEQLREDGPAVEQLADGIPSDPVASPNYSNELKAHEETIDEETAGSDVGDKDDAAKSNSNSTQTAPGGPAAADGTGVQIEERSTADQSTAALLSTDEPSATTTLNVPSTTASVAAAGASDDNAPFPPPAPSRTAPLPIETTTVPPASDVKSPASLPAPPLSPPPPTNGSRKKTLKERLEEAARRRGSPTSPSAAADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCI9</accession>
    <name>A0A2S5BCI9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCI9"/>
    <dbReference type="STRING" id="741276.A0A2S5BCI9"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX-associated" evidence="3">
        <location>
            <begin position="131"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="773"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1215" mass="134094" checksum="B6A82FE848DE90F2" modified="2018-07-18" version="1">MSKWTSERMAFPQKPTGRLRKMASVARPDVAWQLQGRESFFADVPGVDARSRLEDSETLSVDLDPGSANIASDSEGDEDSHRPVHARAPPIFPVRGPGSPRLSETFERIVPALTVNEELYEAASRRSAELSPEEAQCLLRSLVAQELEAEYAVVHSADPEDATHSDDMPVLTYILRHFLLTLPILRDEVDDQDRSTFWLDGLQPILQTLYESDLSRAVDRLGSEPTRHAPLAGTVERFVSSGLKVRPGAIVDTPVPASLPPMPAFPPTRVEAMSRAKTEATNTEVRQIAVLDVPAKRLGAAAGGTRKKVPFWKRALGFGKSTTADEPARPSARDVPRLTARAPRTGMRDAGGTALVEADALLAALSASPESHEPVPISRAPTLPRIDLVGPLQPYDVGLSELSEPSAPRLRDSVLSTDTYLTAPDLDPSLQTTTPRGPWTSPSEPHPTSPRSEQAANGFESRPAEPPFPITDLAPAGPRDSPVDLHVGPSFSTVRWGGFEVDVVGVRKHLLSHSYMLRIRRPGRLDDYVLRSEAAMQRFARKLAMAYPLSHLPPFPTHHPSGDTFVQPPVFSFESENSSELWRRTSAQSFRSLGNPAGPHLAGRNALRSASSSGPLASGSRFTQSLRAQSTISLGRPTRSRASSFTTRAPSEPSGDLRTLRSYALTAGTSGSGGPNALQTAPSLDGRRRVVRAWIRDVLSTRTIRQDLQMLAFLFDKPTHPRDRDVLDILQREAVDSARRQARLEDAYRSLERFEGARQQSTELQRDVVFGEGLDDLSETLRTTAVLRELPPRFRGPLQILLLHAASWLFDTLVEGPGSRARFDRVKQSHAEIPWSRIQAALRVSKTTKMMRVLEDLLLGTGRSRSSSLLEKLLTICLADDPKPIASSLNDLRARIGSSVMTAKLEQFVYESRQKKAVIRRYSVEYGIELVLCIVRGSDLPRLRQFELDRIASAQQAYRRWTRTHSSPPARDTVRDPDVRLVIDLQDYLALVSKERDAAIIRTLLGQEDFASAIEVALQPFLQLLKRLHASSDLGALVSRLEAFLGRLVIVVGALRERVQDPDKSVRAIARVLEEHEQAIYAFLHDLHLRDDLIDELLQWAWTCAVFVRRGLARPIDLNALLPPAGSADRAALLAELEQLVSYANAKRAAAYEATARQFGGEVDADDPVVVDGDGRGKPQVEPMTRGSKAKKPILKELPRYGRAFREQLKDIFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCN4</accession>
    <name>A0A2S5BCN4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCN4"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="734" mass="80227" checksum="578EF800F664DA89" modified="2018-07-18" version="1" fragment="single">VERDHSQTFRERTCPPPFLLCRSEARLPSRPPGVVAADPASLLDKRHCARRKRRPSTLLGGPLHLFPVCASPAILVKEPPLPTPTLDEPAEAPHTLRPSDMTGGRHRSPASEVTLKGDLILEFPSSITTATRQRESTPAAESSLARTRRPVTNSGVADLDVWIESRDSYAPLLPSSSIAPSPTPSPIDSDFGPFVTDAPPSPPPKDAQQPFPATSSLASKGGFYSKSTSIAQARSHKSLKQLQGVSDLRTGPARPLNWRDKGQEMARARKGSGTPAKLGITLRQVVGAVASMAVLSLGAVVYVNSRGKNAVVKHMQRREQVLAASLAPTSSSVAKFEPSHPHDSFRDELATDAHYLISVPHGDFAEQTMNLYHLTHLSGVMHRIPIAHPFLLPDPKQPDVISEHSLPSIYDLARFAAGTSVSILDWNELRPHEAGEAPKIEPLGCWIGEVTAQERTERAAKMQQTGLTPGFVPVRLKLGAAEAGQGDDLKETHGFLSRFDKDLSAQTGLIEQARHVAAAGLSKRDAVPEDQVFCIDHTLYRPEHPTTKHSTSHLDPRDHTAFFKHGRHLHFAPDIHETAGEIAAHVLGHRNPFLAVHISASARASECKLLDQPDRCHVDLLDYQRAIGRVKHVVAQTAGRKNREHRHAAKNLSVVVSTDVKDLAFLGELANLGWHLLDYNDLELRERFGRWDPQLMDQAIESRASGFVGTRGSPQSTLSALRVRTWRSGPTELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCU5</accession>
    <name>A0A2S5BCU5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DHHA2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCU5"/>
    <dbReference type="STRING" id="741276.A0A2S5BCU5"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="270"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="458" mass="49927" checksum="95F9AB3AADEC8044" modified="2018-07-18" version="1">MATQAARSYAQQLRLTKDSFLSQVENGAELSGWVVSVGNEAGDLDSLASALAYAHFADGQGPESDSKRRHVPLFLSSRNDLRLRPENLLALEMAQVPVEALLTIDDLPRDRLANLGTQFALVDHNVLLDMFRSRPQDPADAEDDARVVAILDHHVDERKHLAANPRTVELIGSCASLVTEHFYPSSAERSGAAQPERIPTPLADLLLSAIVIDTRLKPSADGGKAAEVDLAAVQTLLPASSFASALAVNASSTSESSSSSSALDNLRAFNSRLSDAKEDVAHLSGHDLLRRDYKEYHEASVRYGLSTVPLSLSTWLSNFDQPEEQAVETLVQEVRDWMDERDLALAGVLTSYTHIKKSGAAGSRRREILVVARGAQADGSLAKLEQVFAGLEKDKVLELEEWKAKKTYGIDEGSNTGQQGAHDGWERWKVWQQGNARATRKQVAPALKDLVHGAFSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCW2</accession>
    <name>A0A2S5BCW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIKE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCW2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCW2"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008555">
        <property type="entry name" value="SIKE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05769">
        <property type="entry name" value="SIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="424" mass="45693" checksum="6CF712B8B23FF467" modified="2018-07-18" version="1">MTLMDQTQGSDMERLWALLSELSAQLSHNRQQTEELHRRADELKAQAVHAQTGFTLRRFNLDVSQEEFESELERLNVQLVTENQALQQENRQLSSLLKDYESTLEAVMGKFRAHAHATQQHHLDLTRHYESLLLSMPTSLPPPSDMPTDPSNPEAPPIDPEHLNLSLSHLASLIRKALRALQGEDPEDSTSPLLLPMGIGEATSALSDALRRGGHDALDHEHAGPPSPTSSIGSFSSVASSGAVAPPSHFGSEPDLDRLLASHHPSTSRSRALESEGGYVSKRATTDPLYVPTTSASSLVMTPPRPGQARDVEDEMASRGLGPLDEALQRDVELEALRRENEELKKLLRISEMELDDERSGGATAAVALPPPVAPLQAEGQPPSQANIAVTTVAAPLSGHNATSDVSAKEAPSAGDAESSPTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCY8</accession>
    <name>A0A2S5BCY8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCY8"/>
    <dbReference type="STRING" id="741276.A0A2S5BCY8"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000040">
        <property type="entry name" value="Putative ribosomal RNA methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="21"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="304" mass="33332" checksum="2E6618C7856F1B5A" modified="2018-07-18" version="1">MGKSTAVKRDIWFRSAKEEGYRARSAYKLLQLAEQFQLWDGVERCVDLCAAPGSWSQVLSQKLKADEPAVDGSAKVVAVDLQPMAPIPGVIEIEGDITKTSTAEQIISHFKGRRADLVVCDGAPDVTGLHDLDEFVQAQLLLAALNITLHVLRPGGNFVAKIFRGRDVTLLYDQLRCFFETVTCAKPRSSRNSSMEAFVVCEGFREGFSPDLTKPLLDFSYTTAATPATQSGDVNDMAGAMRFIAPFVACGDLSGFDSETHYPMTDKPIPTAPHQGPTAPAYAEFMQLRAEKRLQNLSLDGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD12</accession>
    <name>A0A2S5BD12_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD12"/>
    <dbReference type="STRING" id="741276.A0A2S5BD12"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22748">
        <property type="entry name" value="OTU_OTUD6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="3">
        <location>
            <begin position="274"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="441" mass="48167" checksum="FF33299ADB94F95B" modified="2018-07-18" version="1">MMRRESRFDAARRLMSCRKTTDTMSMSSEAAAQHHEQNVETIVRAAAQVVPPPPALNPLLARGKLKKSNSSQNANKKNKNKNKSTTAAGRTELIKDVYQAKQDELGVVSAGAGAAAVDPHEESEVLDLADQLLQQLGDQVDDDDGTSTEVGGSTRAVGTHTPSGAMSPAPSTTSSHASHGSSARERLHDLKEDIKGAFLPNRKADHQSSASPLMAGVSDGGEKKMGRQEARKLRKAQAMEQQRQEAAAEVLAENDNSVEAERQAIAAQCRKLQLHVKEIDPDGHCMYSAIADQANFLKLPTDRETYMSTRKHAADYMRTHPDEFLPFLPSEVDPENMMGPDEFKRYCDTVERTAEWGGEPEIRALSLHYKAPIIVIQAGTDMVEHGSDFPRERAMLISYHRKMYGLGEHYNSLRPSTHGAPHVLPPAPAASDPIGQRVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD82</accession>
    <name>A0A2S5BD82_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD82"/>
    <dbReference type="STRING" id="741276.A0A2S5BD82"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="43"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="8">
        <location>
            <begin position="206"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="59535" checksum="1FFF31D06D775191" modified="2018-07-18" version="1">MASHHRATATSSWATSSTPSPPLTRFGQPPTTRETLVAYIERACDPSLHEPNLSLDLEIADLINSKKANTPREAAVEVVRLINHRNTHVAMLALHLLDILVKNCGYPFHLQISTKEFLNELVRRFPERPPTFPPPPMKKILELVHEWKNTICVTSKHKEDLVHIRDMHRLLSYKGYRFPDFDRRSAQVLNPSENLQTPDELEEEDREAQAAKLQELIRRGTPKDLAAAQELMKIMAGAEPEKKPNYEEQVNKELDRVQQRVLLLNEMLNNAAPKERFVEGDAYDQIAKKCRHVQPKLQKWIAESAESNPEGMDRLLLINDLMNNILTRYDAFKAGDRSATAEIDPALNAGGAGSKARAQAQQVSLIDFDDDEAFAAPTPPAASTPAAASAGPSNPLDDLASLSLGGPSAPAQQNSGAGSLFDLNDAFGAAPAPQAIQQRPNTSLPPPLSLNGSAPLAPVANRPMQPLQQPAVSGTFFSNQARYSTPGYQSPSPSPSPSVSTFGGGSSAGLGSISLGGAGTPGGGGGGRSSAPPVPPKQQPQKDAFADLLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD86</accession>
    <name>A0A2S5BD86_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD86"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="681"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="779" mass="86755" checksum="0C26C6E942E80F02" modified="2018-07-18" version="1">MVNVRNPFKRQTSVDATTMPTLEQRLSDEREPEDVKSPLDEKDEALGGVEQHHEIHNPWDHVAAEDLDENGKERAIEGAEDLTTRCISLEDDPEMPIYTFRMFFLGIGLTAFAAVLGQIFYFRPQTVYVSALFLQVISFIIGRAWGAVMPNARRGKIWAFLNPCVFTLKEHVAINIMCSTATASASAISVFAADELYYNIEPNYGVAIFTLMASQLFGYGLAGLTRAFCVFPTWIVYPNLLPQVQLFDALHREKDASAQKKRLKLFWIVFISIFCWEFVPEFIAPTLTGISIFCLAKRDSPWFTRIFGGANGNEGLGLFSICLDWNYVGSGGGALGALFSPITTQISQYSGILLCILIFCAGYAGNLWNAKSFPFLSQQLFFLNGSVYDQTLILNPDFSLNKTALEVYGLPWYSMTNAMYYLGCNLAIGATFTHIGLWYWRPIVNAVKSFKSRSETDPHYQKMLVYREVPMWVYGGIMLSSFAMAMATIYTGHAELPWWALIVAIVLAIFLFPFVCIINAITGFSTEVQQLAQMLGAVVVPGNPQANMYFTLYGVNACGQGIALARDLKLGQYTKLPPIATLIVQVIGTVVGAILQLIIMKDVINAQRPLLLSTQGSNIWSGQQVQSFNSQAVSWGALAKEFYGHGSPYAIIPYCILIGLAVPLPFYVLHRFFPRAGFNTYVTPVTCWCLGNLSVGINSSIFMTVCLGFFSQFYLRKYKATWFRKYNYLCSAALDGGTQLFVFVATFALFGAGGSTVSMPNWALNPATGNYDYWSLRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDE2</accession>
    <name>A0A2S5BDE2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDE2"/>
    <dbReference type="OrthoDB" id="2564812at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015454963" description="DUF7729 domain-containing protein" evidence="3">
        <location>
            <begin position="39"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="4">
        <location>
            <begin position="204"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="455" mass="46985" checksum="514A1F0FDA8A840C" modified="2018-07-18" version="1">MDVPRSLPRTVKRQRTRSPLSLWLVLSSAACAAVAAAAASPPSPVETASINLALEPRLRPRTADMAPLGARTLSADYGTTVAFPTGVLGLEEVGAELGHVARSGAADRTDAEDPNEPQRDDRSLAGLHVQREKRQGTTATSTTSATATQASSTSIAQSGSATPTSSIPSSDASTAAWSSSASASASETASAPSTATSGVPSGYQLPQPFDSTLGTNFSSTACPSFFATFLADPAFQACAPFSLLLTTSTGFFQAEKQPTTLLPYALNASCSASIDTCSAVMDSLAAKIKLPNTCARDLALGNPLVTEALDGFRSYRLMRQAGCLLSNTTGQYCFAEAAAKDDPSDLYFYYLPEGTTLPSGTTPDCDSCTQNLMGIYASYATNTTLPISKTYSSGRAAVALSCGPTFAPVVSAVTSTSSARSMRIRLDGVGMAAAAAAVVWMPFASMAVPFLLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDR4</accession>
    <name>A0A2S5BDR4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDR4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="279" mass="31521" checksum="3D548437571D0CA7" modified="2018-07-18" version="1">MPRSGRLHSTMEHRKFSAIMGRAAWIKRPGAAEAVRAYAACTKETKVELKVYAMEMKRKRDERRRSAKQEGLASATDDPKLISKEAAVGDRKPSGATTADSPRSADGTLGELDGRHADNARDEGFGSHEVKQRLTLPTDESPEVKIAFERFQHELVLMFESNRHRNDTVVDVQLARLEQDIAKKYLSAAREILPGWEEAFEEANKNARKRLKSLLAADMQRVRADVTAKQRSVERAEEKVAEATARAEAAEQRRTTQDHRRLLALDDLRKAYLAFVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDS1</accession>
    <name>A0A2S5BDS1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDS1"/>
    <dbReference type="OrthoDB" id="10039103at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="172" mass="18056" checksum="76061D01F5E5461D" modified="2018-07-18" version="1">MSLVPLPPNGFVSVPPKADPATGVEPDSRSDDVPAFCRSCLRPAPLRSRVLSSPHFARLPSLSLSPLHTTRSQLNLSTLIPLIQPTTTMASSTSQSTGQSIVNTISDAASYVSETVQEYTSGASKEANKEVAKDSNQSIGTRLSAGVDALGDKADESKHSAKAEANKKSAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE18</accession>
    <name>A0A2S5BE18_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE18"/>
    <dbReference type="OrthoDB" id="10669749at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39972" checksum="4A60968F68A15DA6" modified="2018-07-18" version="1">MPAFRLPLELELHILDLATPHRLLPSLKRRVKFLRKIALVHRSFTAWAQARLREQFVFTYRTSDPQLLAFERRRQQAELLTDWKPECFLLDLRNFFYADEYDCNCTKSSRRPSTDSLPRAGLLHMGADNGGLEATGNLAAWPARFARFLVYLTHLLVRVCTFDCPPIVDLDDSSCGITWEDPAWGFGQTSQASALTLRHLACSDFSISAPHLTQLVLVQCEIHTSLTRICKRFPELADLFSFRTDFNSGDDDLAALPQSLRQVVIASTSADALEDYEWTTFAKRMPRTLQTFTFTLLQADVDPDEDSARAAVATQHVARLEQTLHNTGTRFTCRIATNSDEEELATVMLALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE93</accession>
    <name>A0A2S5BE93_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE93"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="339" mass="37936" checksum="C18EA7D621C48276" modified="2018-07-18" version="1">MPRGPVAGGELKNALDQLIAVPNVPGRTFGLGNGGGTVRRNWYDSTGFERASVRGALRAEDREKLCNWLGWKKQTLQRALTEGKALTSDILVLGIHIPAGDLQQREARSSRLAAAREDIIKSEGHVRATIAWRTVAEQCKQIANHLWQSAPLNSAARANLTQWQLAVERDIGEERYVALHPVLRAGLYELVMMLDEHVAKLSTAHAKLMLLTQWSPKQLWLRIIRTRDMLAAVHHAAQLHEASPSEHARSWLETESSDAMNLLECLPLPPDHPDEDYSDAPQGPHRHRHHHFELATTGESSMTHPYSDLHALGAEPRLGRRAALYYGFHSPAQWAARRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE97</accession>
    <name>A0A2S5BE97_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE97"/>
    <dbReference type="STRING" id="741276.A0A2S5BE97"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="2">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="3">
        <location>
            <begin position="201"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42739" checksum="BC19369FA0CD2574" modified="2018-07-18" version="1">MVNLNEASATRERFLRDAQPPRALDLRPTSVYEVVISPRWCIRNAAHGGVLVDILVDAVLRRQANASSPHRDPAHLSAQFLSATIPGKATVDVRVVSESKRWTRLEVELYQWTPNVDTTEYLDPKTQRTLRIRAHFLVTTLPDHPPIQSAWTSSYSSEDSINYLSRPCPLLVHPSQIDMSQGGEHIPEKMRFRDAFRWKDVEVVQSDGALASGNWIQMTGGEDITLSAALVGFFADIAKNGPSMLPADQRPAVAWYPTMSFALDFKSKFPLNSSPASAPPGGFARRTFGIYSTTKSIHEGRHDLTVEVWAIDGELGEGPPRADEMDADGVAKWRREGARCVGISTQMALSLSIAINHSRVKTPTLPGESDADSSGSEAEGGERRKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEU2</accession>
    <name>A0A2S5BEU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEU2"/>
    <dbReference type="STRING" id="741276.A0A2S5BEU2"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="140"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="370" mass="40826" checksum="9F869596A912DEE2" modified="2018-07-18" version="1">MAMQPVKVAVVGMGMSTTVFHVPFILSLPDKFKLEAIVERSATAESSKARDKYGPAIKVVNSLEQALALDIDVVWICSINDTHYDFAKQVLLAGKHVVVEKPVTPTSEQAYELAKIAHEKNLVLAVYQNRRWDADYLTLKKLIAEGKLGELSEFTSHFDRYKNVPNAKVWKESPLPGAGATFDLGSHLIDQILDLFGAPKRVTGFVRNSRLLGHLEVPDSFLIHLHYDADASKDGRKLPLIATARGSILSLTTPQQRFIAKGTQGSFVKCGVDVQESQLVAKGADALKDSAFAKDPEELYGKLYTLEKPNEPVTITSETGNYRAWFENVGEALQANDPSRLIVKPEQAALTIRLIELAEQSSREGRTLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEY6</accession>
    <name>A0A2S5BEY6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEY6"/>
    <dbReference type="STRING" id="741276.A0A2S5BEY6"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="195"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="407" mass="44887" checksum="8968261D1B28AABB" modified="2018-07-18" version="1">MAQANGSSEGLPEVFVQLKYVLFSWPNTPLLKRDGLARNWFKTRSTMATFVETLGGFPVTVYEATLPGLVPELFLAQHQVDRMINDLSNLMGPSRAKASFRETAYHHRAELVKGAKSGAAAAAAVAGLSSPEAPPIQTHEFKTQEELERRFGQLKDGDDWRSTTTHWQELRRAQLAWKHCREGVATGTLPGEPHYVAIDVETWEHDHDLITEVGLACLRFTKNGGSQFTTRHYVVAENADRRNGRFCPDARDHFQFGQSTVLPRAQIAKELSDLLTPAQTTGPAVLLLHDHRGDIASLTALGLNLNVFERNPLLPDPETAPDYAEGGSFLLDTQRLYSGFSRRKRQVRLEDACKSLGVALPGGDSLAYHNSGNDAWATLAVFVKLMDAYIGETVNDAKPPGWTVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF85</accession>
    <name>A0A2S5BF85_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF85"/>
    <dbReference type="STRING" id="741276.A0A2S5BF85"/>
    <dbReference type="OrthoDB" id="162638at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_bL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_bL35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="130" mass="14241" checksum="96F6FC2E0E15EAB5" modified="2018-07-18" version="1">MLSLLRPLATRATATALRTSATRAAAVRPCLASWWPTTANRLARITAPFSTTAAVLALVRKPTQSKLKTHKGAAKRFKALANGMFKRAKAGRVHLNSNRSMSSTRLNRLGKTAYARPAERKTLRKLLPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFJ1</accession>
    <name>A0A2S5BFJ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFJ1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFJ1"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="421"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="536"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="620" mass="68734" checksum="FE441AE633879292" modified="2018-07-18" version="1">MATAQFENIYHGLAPNSGKLRIAPSGLGWKSSDENEAVVTVPGSDIKWIQWHRVARNYQMRIGTNKKKQTFDGFLKDDFERLGNLCKQASPLSRPRGLSERRFLFVLTRLRCPATRMQYYNITLETKDVSVRGWNWGVAEVQADDLAFLVAGKPAFTMPLNLVQNTSINKAEVALEFGSSLPPANADGNEDPVARKKRLRMMPDEVSEMRLYIPGSARGMKKKGDKAKAKAAGDGVKNESDDDEEDDDDDAEDDEEGEGAAQAFHDAVKEKAAIGQISGEAVCTFPEVLCTTPRGRFDIDIYDEFMRLRGKTYDYRVAYNQVQRLFLLPKPDDIHSQLVVNIDPPIRQGQTRYPYLVMQFAKDEIMELDLNLDDDTLRDKYQGNLKKHYDDPAYEVVSILFRVFTEKKVVTPGSFQSHDGQAAVKCNLKANEGQLYFLERQLLFISKQPTLVSFNEISAIVLARVGGALPSARTFDLSIRLKDSSSVAGGGPLVFSALSKEELQTITDFLTMKKIKIKNEMEELAAVEAAVLDASSDEDEAMMSDGSDSDDGSRRKKKPTGAANAMDLDEDEDSEVDEDFQADSDSDGGSASSDDSDSDDGAVSGDDVAPEPKKKKQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFU5</accession>
    <name>A0A2S5BFU5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BFU5"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="3">
        <location>
            <begin position="948"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="4">
        <location>
            <begin position="1520"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1720"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1725"/>
            <end position="1741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1800" mass="194498" checksum="1E3A317D3D9BE916" modified="2018-07-18" version="1">MSPSDTDDLPDWGVSSNVAAVRGRDDHAGFPPEPEPTHPVDYSAQLRDMLGDAGDTLNVTGDENDEEFGEFVYTGRDAGRTSRRPDDDDDEEDDAAEAELPPEGSQATSQEVTNGTVSPVQEDTATNAVPEPTSPRRSNGGASSLGDGRPSPLSPAESRVTSASNDEFPALRNRREGLTRARSSYGSIASIAQSTSGSQFPQRPLAHPAFSRLRSISTQTTPHSRNVSSSTYNTALEYPTAADGPPQRPGLASGAGSVSRSIFGGASRRSSVSNILDLPSASEVPTGTSVSGASSIGAGERVRPAARTVKWSPLRKISGRAFPPATGSAGAAALSQAEQMVKSSMGQPTVMAVHGLIAIGTTRGWTLVFDFTQNLRCVCGTEAIANESGAVTALAVSQDHTFVAVGHENGSIHLYALIKPSQPARSVPPVTLPQVLSGRKEGHLVGSKICRLGFAGERHTAIVSSDDQGLAFYHSLGKVLMLASTDIIRMLGRYPDPASAPSGAAAGTAIPQRPPLSTAQTAPPRASVASPPDSRPESPADFAQRPRIRSTDPDQPAFPRPSRAAGPLAGSGKKPAVVLDMAPLPLGSAPHPASDALSLVAILTPTKLVVVGLKPTPRTWWRFALPRRDPELPDPQEPDGDAERGFAVTGVLAWWPSQRRGGEKVENNDRKALVEEGESPLLAWASGKRVRVARVRSKGDAAAVAPATRRLAQNPLKAPPPPTGVDVETFAEIECDAAVFGLRWYTERVVIVITSANLDVFDIGTKQRLGRDPINIDSLVSSDLLSSAFEPFLPCDGVLATSYSGAFAVYKRKLFELRREDVRAGAILAWADRVLALMQPATILDAIETATAYYSGQVDASTIFLPESPSERRALLEPRLREILAASVDFVFSEDRLRDGSHSDGETIQRLFEGLVATSVHACLALGDADWLFDELYERYEQNGIEGIFLDRLEPFVLGGAVHALPPSVTQRLIAVRADRQQYDAAERIILHVEPSNLDLNQALRLCEGHNLYDGLFHVYSQALNDWTTPVIEVLDLVQRIVEERQGRPRHPEDGADPVASYGADWSDSQSPAWMEHVGSYDERVETLSPTVYKLFSFLSYTWLGLAYPSGCALDEAPAVQGRRDTFALLFSSSAAPPSKVSGRSSLVLPDIPYPNVTLLLRYDAEALLDTLDQAFEDPFLDGEDGMPTSVVSAQMQRQDIVDILLHVASTDGNGLSSVDLTFIRIFVARNLPKYPQYIRLSPATQQQILVNLVTDADQSTLEDRQLATEYLLSTYTPPEIDTLVPLLERAGFLRILRQLYRSEGRWSDLAMTYLRDDTLEGDIFALLESALQLSARAGPDEKRKLADVIVGSTSDLATRGESALSRLARLVSTFLPDRHADVLQHFDATEWRRFVYLRCLFEPEEGDGADVSPDPALLRDYVASLCRSDPRHLVTFLSNRPTKEAQDPDLLAVCEKAGSYDALVWALDKQGEPVKALARASEALEMRTDSLLELLLDANQTESPRSIDSRQRNTSVAVEQIRAVTATAIQVCVARTTGHRRLKGVDPEELWYNLLSSLVATLRAVRSIAPTGPSNHRDAAERRASLSSLIQHGADEQALGGNASELLSTMIPDALSALVSSTTSQDVSFPRLVRRLIEATPSGSSTSSSYAEFKGVITSMLDTYAFEGDLLDQSSVITAQDLFVVVEAFKQERERGWRPGRGTARTSCAECLQPLWASGDRPTSPAMSRSASASLLAESLGSERPRMQKRPSIKGKEVDWPGLAPPARSPNLLSQESASIVAGKDGRLWHLACHLVRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFY6</accession>
    <name>A0A2S5BFY6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFY6"/>
    <dbReference type="STRING" id="741276.A0A2S5BFY6"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="368"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="936" mass="99056" checksum="729FF6C41E1F1B54" modified="2018-07-18" version="1">MAAALFARTSASTLRRLAGPSSPLAATSCPASSFSTTCPPQSQASDSSTGGANFLRSAPPRPRPATSDGGDGEWRPLQPRPPRQQQRSGGQNRPRSPSTASGSTNGSGGGGGVSGQRGAPRPSGPGGGNTNNYRRPGPPRSNAGAQSGRGPLSSSSSSMAPRMTNGPERDYAQKREHDRLRRVDPAKPKPGATSADHQRTQADRFARSAVAIGLDPSLVGSELDHHRERSRRYKGKGGPAGEPSGSDPVMLEPWQIKREQEQAAFAARQRQQAAARPKKIKAKQVLKKVELPSTLRLDNLVNILHERLFIVQRAAERIGLEDVRPDRLLTSEDASLLALELGFDPVIDDEAGFDLFPLPPSPPDLVTPRPPITGIFGHVDHGKTSLLDALRSTSVASGEAGGITQHIGAFEVGVESMVANLRAKADGTAAPAAKPLKDGEATITFLDTPGHAAFTAMRSRGAGVTDVAVLVVAADDGVKPQTEEVISLLKSAPDVGVVVALTKCDKPGIDTTRVKHELLAADIAVEELGGDVPCVEVSSLTGQGLAELVETISALAEVRELTAERDGRVEGRVIESRVEKGRGNVATVLVLRGCLRSTASLVAGNTWARVRTLLPPSGKAITSAYPGQPVEVTGWKDLPTAGDVVLEAATEDVAKRAVSNRLRRLEQEKMWSEVEIINEKQKRDAEVLAVRREEEEKAKAKGLRGNAVLHAGDLAVEQLSAGGEQVKELLLLIKADVSGTVEAVVGALEGIGNKEAKVKILTSAVGPVTQADVDMARTAGATIIGFNVKAPGSVMKDAAKGPIPVPVHTSPIIYRLVETVRNETAALLPKNVETRVHGEANVQMIFEISVKGRKQPIKIAGSKVFNGVFQKARKARVIRKGETLFTGPVSTLKQVKKDVTEIPKGVECGLALDGFDDWQVDDLVQSIEEVEVARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG31</accession>
    <name>A0A2S5BG31_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX14-like KPWE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG31"/>
    <dbReference type="STRING" id="741276.A0A2S5BG31"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="104"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="164" mass="16930" checksum="F541AC047956742F" modified="2018-07-18" version="1">MQSDLNDQRNDKAAPAGYTTLTDPTFLASLPATARGLAVDPATDAQAEPDLQQPQPHEALVPASLAPSHPQQPASESDPSRASFTDATSPQSPSNAPSAADDPPYPPTFAELAQMIATGAPVPGIRDIPDLLAEGKPSESTAQVPKKPWERAGDGVPADAMSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGL0</accession>
    <name>A0A2S5BGL0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGL0"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="348" mass="37467" checksum="998C8402813FD90D" modified="2018-07-18" version="1">MYAPSSSMRPRTSVKSGLPAWDADEVRDAVRDVSAPSVSLFVTIMVRVLPLVATASWLATLTALLILSGDDNGRAYFSAYGAVPYISDAAYGHPKIFLWGSCATAAFFVASLVTERILRAHRVLAEVTDARTLWHVVAIADVWAGALAAIALLGMAGYDLVHYPQAYAALATCAVIFLSLSGLLQTVEVTRLWHEHPDRRDLEAGCFTKWTLITLISACGMVIVCLHVQCDRDLFAAPTASCYRVLTGKAILQWTIAYAVGAFLATMIIDLWPVHRHTLRTAPTMHVGRFGLIHGMWMPHAASTSSASQTYVPVPPRCGVLRFPPKYAGSGGAPDCGVQVVPLARASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGV1</accession>
    <name>A0A2S5BGV1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_0729</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGV1"/>
    <dbReference type="STRING" id="741276.A0A2S5BGV1"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19504">
        <property type="entry name" value="RecA-like_NSF-SEC18_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="349"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="630"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY76006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="839" mass="90668" checksum="2866F821953DBA03" modified="2018-07-18" version="1">MSWFSRGDTNTPPAQPPRAPQAAGYGQLPGSAPAPPPRHAAVPPGYGQPAYEAYAHQQQPPPPPARLSEKRAPSSGAGGNQFHLPTRGGGGGGAQHAGRGAASSSGGSFAVVEAPSPSHALSNRIVLSEQDWAGTPYVVIKGQFLYATMFDPKVAPGSIGASRLVRQFAGLSQSGDVVDVEPFDPYSLGSDIYLASLDLEIAYWFEKNAQPTAYSADELQDVFRRAYDGLIVTVGQPLVFDFHGQNLRATVKGLHNLALEGKGAMSSSHSRSGILTSQTEINFVKDPASAIKIKSSAKKPPPNAILAPNFKFEDMGIGGLDTEFSAIFRRAFASRIFPPGLVEKLGIQHVKGILLYGPPGTGKTLMARQIGKMLNAREPKVVNGPEILNKFVGQSEENIRKLFADAEKEYKEKGDESGLHIIIFDELDAICKQRGSTNNGTGVGDSVVNQLLSKMDGVDQLNNILLIGMTNRLDMIDEALLRPGRLEVHIEISLPDEQGRVQILTIHTSKMRQNGVMGPDVDLMELASMTKNFSGAEIGGLVKSATSFAFNRHVKVGTLAALSDDIDKMQVVREDFLNALEEVQPAFGVNEEELQAVVQNGVIHFDEHIHSILRDGKLFVEQVRTSQRTPLVSVLLHGPPGSGKTALAATIALASEFPFIKLISAENMVGFSEAQKVNHLYKVFSDSYKSPLSVIVVDGIERILDWVPIGPRFSNGVLQALMVLLNKRPPKDRRLLILSTTSNRSMLTEMDAMDGFASTLRVPAITTLRQLEAVLADVGLFRTPQELARAIDLLRQAGLDGEDKLAIGVKRLLTLVEMCRQDQDSAVDKLVTELVGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGW0</accession>
    <name>A0A2S5BGW0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGW0"/>
    <dbReference type="STRING" id="741276.A0A2S5BGW0"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015534630" description="RRM domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="166" mass="18362" checksum="684F788B25797644" modified="2018-07-18" version="1">MGWSSSLHITSWMVMAASSSSQSLARKDPILIVVGADLKDFARAAGHVTFADIDRRDPTLGFIEYGSARDAEDAVRKLDGTDLVGAVVTVTADGPPPPRDGGRGGDRGGDDGYSRRSTRDAYDDRERDRRPRSPSPRRSRSPPRRRSPTPERDTRERSRSRSPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGX3</accession>
    <name>A0A2S5BGX3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGX3"/>
    <dbReference type="STRING" id="741276.A0A2S5BGX3"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="4">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="570" mass="61984" checksum="C76C2CB1E9009DBC" modified="2018-07-18" version="1">MPVPPFHFPLLPQSWYIGHMRRAMREITELVQSHKLDLIIETRDARLPLTSINPAFERLLAEQAGRGIGAGLDGGKGIGTTKRLIVYNKADLAQDCFQIPLQRAFAQHDEDQVLFTDSRSDQEVKQVLEAAISCVAKKPQTSTHGLQLVRRPLDGPDDKITMLVAGMPNVGKSSILNALRRVGVRKGKAASTSSEPGHTRRLSTHIKIASDPPVYIYDTPGIMVPFLGKGVAGQETAIKLALTGGMKESLFERDLVGEYLLWRLRIRAEMRDDGWSNDELLRRLGLPVDTPLDDPHSFFTSLAHRLSAMQRGGIPDTDHASRWLVQSFRDGKLGRWTLDGLGRGGEAVDDQKDFVEVARGHGDRFELWEDQGEEEGGDGGGAGREEEEGKEMKWTRSEPRQGYLSRQETAPPVTGTGDATLGEITPPLVAAPATTPPPSPSLAADDDGDEAVIEPYVAGSVTSYLTYLASLASSVDLRSAHQSRKAKKADQAKIRDFKRKGHQVAKVKTYTKPTSSSSSRGGSGAGSFKKGGRSGAGGWFSRGAARGIGAGARKGPAIKLSSGRRRQYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH53</accession>
    <name>A0A2S5BH53_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH53"/>
    <dbReference type="STRING" id="741276.A0A2S5BH53"/>
    <dbReference type="OrthoDB" id="2530135at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="402" mass="41133" checksum="704340E95187E0E9" modified="2018-07-18" version="1">MTRLWEYARLLFLQLTPTSAEMKFLFFGALVAGLPNALAAAEAGSGPGVDAQQSRSDVSKDLSEVTEWKELCYVDLYAAAATSTLKYTKEVLSKDASGRDIFISDGYKKDSEGKDFYYLETCYRSGSTQGSTRTSKDASSGATELNPFVSIVDALDIGGTSGDLLSGLASGFPLVFGNDGGALFKRQNGSSTGQDDSALADLNRVSQAIGGPDNVLDLNDSGSGTSPSSDPTETRPAGGNSGGALGSTDAGNVWDQSDGFDGALEGLDRFGANPFARPSPTTTTSQGPRILRLSTIDVQTSILHSDSRQTSTMAAQPEQPFFASASSVFVPGTPSLGSEAPTAPPSGSGTPGAVAPSTTPLTVGIVTATQPASSLFISVGGGGQVTGSVTTIATPTPSVRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH92</accession>
    <name>A0A2S5BH92_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH92"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="526" mass="57446" checksum="C166194E1F962548" modified="2018-07-18" version="1">MLKRSHATAAAPKSATPSLPDRSSKRPRTASDKQSIALDSSEDASNTIDLTSDATGRVVSLFSLDRLVGTALTDTRLLTAELFAVFDDDDDSAEEGGGSGGGPGNKDFSEEEENISSKLATLEEYAVRPLSGLDQANWTSLDRAWKAYLQLEIARNPKYWKGLDSTGGLVRTHEWRSRSFDEALLRSIDVPRPAADAAAAGTLDSFAPRFADLASEKEMADTDRPLVYILIKNDEEAYLGYSKSGVTRLVDGHEVAEPSERMAAARADVPFDEWRKKVVATIKFHAPFVLLFGEHMLITLTNATVKGLNTLAFDFAGGSGLSIKKVKAVMIEVFDILAPFDPKLGKRVPNGTRLNKEFLAQHTDKLFAIVPLKIESIYHLLMGYWLPWIARTIFAKEGVDASIFPRGRWPMWLIADREERDAAFSDRAKRRAALRSDGWYDLPDANHTKNRLVATAAAAAGPVESDNLTGNCVSTNDGSDAGTSSRSEQTKTKTKNKTGGKDRRGKPGKRAQSVHAGASANAQWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHC3</accession>
    <name>A0A2S5BHC3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHC3"/>
    <dbReference type="STRING" id="741276.A0A2S5BHC3"/>
    <dbReference type="OrthoDB" id="3149405at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="215" mass="24446" checksum="1BE99F47D417F8F0" modified="2018-07-18" version="1">MALPVQARTETIENGVKTVRLTWTVDTDSGADRPRIALGRTADALVLVAADKQDREERFDEAYLSSLSVLVNQDPYPGFTMSGKQMIWVKDYSENKGIVPQLERAGFLRLVGSKIKQGLVELPLAEVTLDDTEMIQQCAKCGQWETSDTSPRYKRCSKCKRRYYCSAEHQHEDWSTHRADCKDLVKMRFADVENRRREAGWNPTNTSKIADPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHE7</accession>
    <name>A0A2S5BHE7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000007">
        <property type="protein sequence ID" value="POY76191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHE7"/>
    <dbReference type="STRING" id="741276.A0A2S5BHE7"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="49749" checksum="F5AA20B765F6A8B5" modified="2018-07-18" version="1">MPRGSRPVSAAPPLPRDQSATHDSSDDLDSVSHPVDRSATHPAVPVRASGGTSGEPGARRTAHAPAAATGQVKPSRKTRVDATKGTYAPVGDQAGASDSSDFDRSHPPSDGDLEVTPATPRSKRKQGKRALGGSDLEKSPGGEPESEGWSMTKRLVVGGLALFAVIVIAVVAFLMLHGSAASNASSATSSADSLASHANETASVASNSSSAASNSSTGVISGLGAPSADGVVTSPATSLPSEASMATSVQQPVQTGVVSPSVAIASTASIGAFGPIGGASSGSAHAAATATSAAGSPAEHGQPGLPSVASPTEPSLDLAPLQSQTVPSASILPAFDDGPLTAASGEANPAFPSGVATKTAKGVSAQVGTTKISTTATRFGASQHLSACHEVFDDGALVAAVHPALFGSDGSTPSELCDAKLHIWQPDSDQTITVSIQDVCSNCPTPTAIDLTQAAFLKLAPDRDTALDQGVLSVQWWFDDVALQQRLPIGFDQWARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHM8</accession>
    <name>A0A2S5BHM8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHM8"/>
    <dbReference type="STRING" id="741276.A0A2S5BHM8"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="681"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="713" mass="79570" checksum="71F9BCAA596D25B4" modified="2018-07-18" version="1">MTARSPVDTSTRRWRPQWSIVDLTVNVPSTAAAPRPSASASTTASTPARWKTREFYFYYLAFVVIVPQMWYIAHRATNLTSNHYWAFAPRLRQGWLFGLQMDLSDHQYWLFRSKLPLLVLLALAHVALSRTYRALSRRLSPALNPNSPSYSQRSARDSRARFSATFSLILLAALHGTSLFKILVILYCNYRIARLGALAHDHSLADQQRRTGGATTAAAVRGGGGAGAWRWRREWTPYATWAFNVAILFANSLAEGYYFSSIHPRLAFLDEYKGLLPRWHISWNISMLRLVSFNMEWYWASSAAVGATMAAAGEPGGVLPEPPTSPQFKAVNERLRRATPPGQAALDPSPHAGNYCFVLYLAYVLYPPLYLAGPVMAYPSFVRQLAPAAASDAASGSVPSLDALVTNGSVPDKVASSPSSHAAVAASTLASETTPRALALYAVRFLACLLTMEVVLHTMYVVALKDSGKGWWNGMTPAEVSLVGFWNLIVVWLKLLLPWRFFRLWSLADGIVPPENMIRCMANNYSVLGFWRAWHRSYNLWVVRYLYIPLGGSARPLLATLGVFTFVALWHDLRLRLLVWGWGITLFVVPEMVGRALVPATKVDSLLLPALFFFPDNETLLIAEPSRLQYGSRPWYRHLAAIGGVANILLLMTANLVGFVVGVDGGKELWRVMLGDWEGRLFLLTASAILFVGVQVMFEYREEERRKGISRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHR2</accession>
    <name>A0A2S5BHR2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHR2"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="82"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="632" mass="67301" checksum="E1018608130E62B8" modified="2018-07-18" version="1">MDRERAYPPPGPVRQPSKTPLLATYAPVEASQEPDDAFPDSLGANTDDDETAESSPPPGDGTMTPLDNALEKIGMGRYQYQLLVLCGMGWAMDNMALQTISVILPRVQEQFQVGDRFIGLLSTSIFSGMMIGAWGWGSFSDAKGRVPAFNLTLAITAVFALAAAFAPSFGWLCCALFWVGTGVGGSMPTDGTLFLENVPKTRHYLLTALSVFFSLGAIMTSILGLVILPRFSCTVVATETAVACDGEHRNVGWRYMLGALSAVSAILCTARVLMFRLHESPKFLVASNQPSAAVVSLRRISKINGKDSPWALSDVVDGEPASGSLIAKSPPGYEATGHTSPESRPRSSMASPLQVPSTALEDGELSDFTLPASVLSADDVTDTPKWIKRLPRPLRGAANEYADRRGDLLAPKWRKTTICVWMIWTLASAGYTIFNVFLPKFLESKLADSLRLPKRLCKHVGSPERASYCSRADLGALDVLYTLSGLPGSLFGAWLVETPLGRAKTLAISTLGTSAATMVFVFVSSSVGIVLSSMAVSFASTLMYAVIYGFTPEIFPVTMRGTASGIASALSRLAGIVAPLVTGILLSVSTSVLPLSLSALCLFATAAAAWGLLDVEERMGIRGRQRAGGAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHS3</accession>
    <name>A0A2S5BHS3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6 8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6 8">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHS3"/>
    <dbReference type="STRING" id="741276.A0A2S5BHS3"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="10">
        <location>
            <begin position="65"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="353" mass="40984" checksum="B737776240779FAE" modified="2018-07-18" version="1">MKRTTPPESPPAPTDRSNKRRASPPSSPESPAKRTRPDLHKKRSDSLPANPLFFYKEPRGTTQIATWNVAGLATCNAEKWKFGFRLYVEAEDPHILAITEVNEQDADSVFENDPNFEFLRELYPYRYWAYKVAVVSKHKPVAPPIFGFPNGTRYDPEDGRARCLTLEFETCFLVTTYVPNSGAEFKRLDRRQNWAADFETHLRALDAQKPVIWTGDFNVIRTITPESNETNDLQWPQNMGQAAGTHEIERAAHERLLGKQPWLKNPKRPGPLFVDIWRLIHGPDWRQYTHSSRKLGGWRIDGFILSERYLWRVRKCEIRQEVKKKFWPAKGVVKLGALSDHWPVWLSLELEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHU5</accession>
    <name>A0A2S5BHU5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHU5"/>
    <dbReference type="STRING" id="741276.A0A2S5BHU5"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="3">
        <location>
            <begin position="95"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="4">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="48567" checksum="6978AF1FD48B5240" modified="2018-07-18" version="1">MAPCQLCPPVAPNRAILRRPKTLQPVCKDCFFLVFETEIHHTIMGYGQAEQASEVTGRDKGKQRRIDQDDDDDDNDDSGSRAGPMRKHLFRRGEKVAIGASGGKDSTVLAYVMKLLNERYDYGLDLCLLSIDEGISGYRDASLDTVKRNAEQYDMPLKILSYSELYGGWTMDKVVAEVGKKGNCTYCGVFRRQAIDRGANILDVDQIVTGHNADDVAETVLMNVLRGDLPRLQRCTAITTGSEGKPASSSSDPTGACRGKRDRTGADDAEDGLEADEERLDNLLPKTIKRSKPFKYVYEKEIVMYAYFKKLDYHSTECIYAPTAYRGYARALVKDLEAVRPSAIVDLIYSGEAMAASLFLRGRRAGGELDPILQAEDRARRGVKPAKGKAKDGALAGSAAAGGHKGQVQQSCSRCGLLTSQPLCQACMLLEGLNKGVAKVDLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHY1</accession>
    <name>A0A2S5BHY1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHY1"/>
    <dbReference type="STRING" id="741276.A0A2S5BHY1"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="75522" checksum="7DB47996AF3A8314" modified="2018-07-18" version="1">MPALEKRYDQDESSGSADEDFVNAGSRVATPRPSSASGTARPSSRGSRASGGSRSSRRAKVHSSSSSESTDSEEEAELRDELADVDVEAGTVRGAPVEGRVERVMRSITKGTASTGAKRYAAVDPVTRKSSTKSHRSGSQHKRKSSRRAQANSLGDDLTRPKKSKVAVVAVDPALSQPVKRKSRWWIYVLVALVLLIIAGVVIFFVVRNSKADGSDAETQAMTNSSMAAEHQNATLTAASASGGVSSSGNATLGALSLASATTAATAAIATGSASAVSFDNGQYHPAGAATAAAATGTTAFGASPSVSGLQAGLQTASASSTTTSSDVRMSIQTQNAGNNPTQPADYAQSTQPAQTMNQASSPTSAPASDATTGHQTDHAAESTLSHSGNPGSMTMPGGQGGVATGPATGAAQSAQAAPSRPAQPLSQQGQQQPGTSAQQGDARPTNGWSTGPSPSPAWQQPQVGTPTWSQDGLQAQDGKPSWQQPQKGSPTWSQNGYGSGAQQDQPGLRPAPLPVGVGPVEHGEASNPTNPAEHGDSGAWLPSNGAWNADSSQGEPAGLHPFANSTAYQAQKPAPFQNLTGNGTWFESSQHYGPCGFATDNSDFVVALSNQTWTASHDAKAANSPSKLCGAEVLVTNAENGVSVKAWVAEHCSSCEGENALDLSKAVFEALTETSGGLDRGVVPILWGFTGNVSRVEPRRNGSSKADSDDKSRSKDSPAASSSGDSWFTGWFDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI99</accession>
    <name>A0A2S5BI99_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI99"/>
    <dbReference type="STRING" id="741276.A0A2S5BI99"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015403887" description="EamA domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="60629" checksum="98FD68344E2B5FE9" modified="2018-07-18" version="1">MRTRNAACLLAVVLVAYTLQTELASYVQHGLGYKKPYFLFYLTHSSYLLLFPLHLAVLAILPASATSTRIPTLLAELASTLEEKFQPPARSGSSSSTSSKGGSHNAASLRIPSSPKLYQHVEHRSVFGWCQAVKQALLVRVRAPWIDYLAKRVLLLTVLISAPALSWYGAVPLTSMTDITAIYNVFAFWAYLLSLYYLPAPAHLRVSSVLRILNFVAVLLAVSGVFVIAYGDAIAGGHEEEGKGDSGGYDSQYRLLGNGLALFGSVAYAGYEVWYKLHVRSRFFMRRAPLRSNFRAPRTDEPDISLPEPPDETPLQDLGGHTYEPAPSDDPDAGGLSAFPGIETETSSLLRAPSPSTNGLSSDPATPAPIPVESARRASPSFASHGIEARSRAPPPSQIVTPTLLLLYSNAITSLIGLCTLGLLWIPIPLLHWVGWEDFEVPPAGAGLAMVGIVLGGIVFNGGFMVLLSLWGPVTASVANLLTLLLVSLCDALFVPSAPPMTTSTLAGGGMIVCAFAVLIVAEMKGEGTAAAATTGTDAEEVGGGARSRIDGRKGLERISEEEVEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ33</accession>
    <name>A0A2S5BJ33_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ33"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ33"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015373870" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="496" mass="55021" checksum="BC23F0FE17C7B1B4" modified="2018-07-18" version="1">MRFFVSWTVLVVGIGCSLAAVVPQIPFGSPTLSSETLTTAHARPEFPGHRLRVREPKGLCDADVKQVSGYLDTDGGHHFFFWSFESRNDPKNDPVILWMNGGPGCSSFTGLLQELGPCKAQPHGQDPVFNPYSWNSNASIIFLDQPVDVGFSWSDHGDKGIYTTEAAARDFYAFLQILFEAYSDTLGSSEFHIAGESYAGRYIPLFTDYIVKQNARVHETGNRKINLASTLIGNGFTDPLLQYASYAPVACTNETGYGPLISERECTKLKAAIPRCEQLVKACYGDVHNSALCVAAYVFCEARLTSAYAATGLSMYDMTKKGDYVENKWIEEWLNKDSVRRELGVDVDKHGHGVKKFVGCSDKVFRHFEQTGDTAKPSFHQVANGLENGVDTLIYVGTKDFICNFHGNQAWTLALPWSHKDEFSAEPLRPWYAAPSSEGSGDRIEDERPRAGEYRQFGSLAFAGVDGAGHFVPYDKPAEALALVNRWIFKRKVGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ91</accession>
    <name>A0A2S5BJ91_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BJ91"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="10">
        <location>
            <begin position="708"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="9">
        <location>
            <begin position="1526"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2031"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2057"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2074"/>
            <end position="2092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2092" mass="222228" checksum="18513E23FD5591AB" modified="2018-07-18" version="1">MAAVASTSTSDATLDSTASTLSWSTALVLLDAASVTGSVAPSAAAFVSANRAQLERPHDPFSRTSKSTANALVTKPAAAAAAAESPQRKQLVQAVADRFDIDSQLASRAVQGALSATTGKGKGKEQDYLLEDEWDRVTAWVFEERMAVMGVVALFLRTHDDESHPCYALASELIPSILTDSFCPSLLASFASRTSQSLPDAVRASPSHALFWTRQLICEQKALLELVFLAYYSPRPARGTDLVAVLDAIQATEWGQRQHLFGYFDAETQAVTAEIGHLLTVLAIEAMNLESAMEQDYPIGAPGEQGVDKESLFAPENLVKANEAVEAVVRVDNARAAPVLLGWAFILSKVTTSLLERGVPEAYHAFAEASLRVDVPVTGSTARSPRTTTQPLFQLYAAHALAPSSSLFPVLGAILQSSLLGAGSGSTADPNAVGYISVLRGLVTSLPNLVRLTFLSAEQLEALYEVFAALYGSPSAAVLCAQFWEDQAVVASAAAAHSDPDLEASLLLLNRTAQNSGDAEIVDLARSRFPVQFGGLVKLVRALCAGVNGLLPVDHALNGTAADASDDNELLAAKCAQTIFAYLATLPTLTHIAPSGPGVTPLPYEAASYPDPAMGYAFRVVRPIGVSRSVAIPIGTQGRLVSANGSKPVVVAWDVQWSAWRLFADMLEDYAGLGHAGSKRVRADVFGSKEALTDRLPMEWDSEEDHERDVTAVLEIMRVTLQNDHALAPVLVDHLSTAPGHQTTNTPRHDLLEVLFRILERSLAPNSTRPASTALVSSLVGLIAALLPSFPGVVWTFLRGSTLLFPSLRTNGAYGRSAASFTAVASSPLLQAEKLTGRYPVTLSLLSLVHKLVLEEQVASGVTSPEYREVKRGVLVRALKWVRDDVWPVFGSWRYATLAEKYALSRSCVQLFRLVLEQAQVDVAKQSVADPVVQVVTDAFITPKATVAQLAPVLSTLSSGPDGIILLRKAGRYADAQALEDLVDSALGLVLDLLRLRRRTQRLTTSLLEKLCLSPASTASYSAASGPRAFGFSAVLSGQEPSRRPELLESLARYVVAPLDTHLAVQAAQIVTLICLASTASEDGSRGAVRINSLLGGGDGCEAVLKALLSVVEDHLAASELQVAVWDLISAIVDSQPGLAMLVVTGRAYPFSTETDIVMANKDDKGKSKELTSAEKSAQDLAKSLAPKPPQPLPRTAIGVALETIGTWSDAWDKQPAVLAAVLRFFDFVWQHLVDYGTALDDLRSKSATWETLVKIAFASTGAEPATEEDIVAHCCRTTARAHAARILALDVHAAIGKSKGKPEDAASAKALLSALADARQVTSLLSAAIATSCAPALHSGTYELVGAAFPNLDLDGLRNVPSTHALDESRAFGAGYLFALPMVRRRLDGYLAESEAMNGPESLEDAVRQVIKLNLNFSLLEAQVLDTRSWRQLLETVAPIAQSRRAIADAVVEGIKLVGTEIADETRGGEVMETVQAERLSILLVLVQLLESGEVDKVKASSVELLTSISKIFANETLAPLDSFVRRAPTDVHGTLFRTAFFAVRLATTHFSETTTTTPERKAQLCALIESILRYTLTALRDILVLARSSKDSSLEQDLSLATAVLTQLLRSPFLPAAPVWLAQLYSLDFLRAAFEVLVHMDVGADGRPLYAHHVLDLCLAFATSSPRAAEQLALDGVMTALTNNALTAAAEAGAIAVVSPTEPVRTVQHELWTAELRLVVALIAALGDSTRFVEQDVTGFVRLYGLQFIRALEWTSDAPVTLAGLEELAAVVAIMHGVARASTSFTAGSASSNSPVVAIARIFVEQSLHLLQHIVYALLHPNHLASQIEGLSPEERARLDKEANSIAEVEKRPIASLVAGKMAQLARDVVAALVAYGDAWSTLLRDPVEWRTDRACVALTPTVTSSEPASLGTLFDLVSFAIDMLRSPPATVSNPTTNSAKSIDLVSVCSETLESTLVLVTSQLMLHSAALASGSSASSHGYGLDSNDVNASGGSTSGGGTPAEKHRALLELASDAVELLDKAAVLPSAPASTARVPGAAAPGGSPTRTSMTPAESRKRLAEVLKNRLTVWVQGSSPDRSGNGPTAGNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZC9</accession>
    <name>A0A2S5AZC9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_7105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000174">
        <property type="protein sequence ID" value="POY69894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZC9"/>
    <dbReference type="STRING" id="741276.A0A2S5AZC9"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="248"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY69894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="66475" checksum="88699465D38DF49F" modified="2018-07-18" version="1" fragment="single">KVQLVIPDRDGVRPTRKIRSLEAFAADDEEQAFEVEGQRMTIAQYFKQFYNVTLRRPDYPCISVSKIARWPLELCNVEPGQKWTKKLDPAQTAEAIKRTTVEPGRRTSMLTEGLSRIQPTPAALGQWGVSIDQQPMEVQARELPAPSVIYQQPVRPREGVWDVRGQNFHKACAINNMLVIVFDSPQFFSLTDAQTCVTGLVSACRRLGMHIAHPQPDINYWPQGADVPSFIQSCGAALMQKMGTPPDLVICFLPRKPCDMYGEIKRFGDQRVGVATQCMFENKAKKGGEPYFSNLALKVNVKMKGGVNSILQPSDLGPIARAPTMVCGGDVSHASPGSPNPSVAAVVGTLDPTASIYGTAITVQPSRLELIARLEEMMLKLLKQFWERNGCLPEQILFFRDGISEGQFSHVIAGEVKAVREAAAQAGRALNIEYKPKLTFICCGKRHHISLFPKNPRDGDSKTGNAKSGVVVDTGVVSPFHFDWYCMSHKALLGTGRSGHHTVLVDDSGFTADELQPLVFHLCFTYAKATRAVSVPTPAFYASRLCTRAQLLLSQEDDRTTVISSTSDSSQERMRQRALVEAQGRLKDIHPDQKERLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZI5</accession>
    <name>A0A2S5AZI5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_7042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000161">
        <property type="protein sequence ID" value="POY69950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZI5"/>
    <dbReference type="STRING" id="741276.A0A2S5AZI5"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="358"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY69950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="953" mass="103175" checksum="52CEC22AFED51090" modified="2018-07-18" version="1">MSITIRPLSADPLPPTYLLTVDGARILLDCGAYDKSSETTLPGIEAKGSEGAEPTHDQVAEYLSTLRSLAPTLNLVLLSHPLLTSLGLLPYLRARCGLRCPVYATLPTREMGRYAVEEWAEARSAAERNDARYEQLRQSQSAAAAKIEAAAAAASKKRKGKATKIEAADVEMAIADGEPATAANAEHKGPDDETNGPDETDAQSDPWDPAWKLTIQEIRDAFLAINAVRWTQPIHLTGVLKGYTMVAHRSGHTLGGSLYTLRPSLSSSLSPASSASSFLYAPAFNHVKEHHLDPTSLLNAGNVDDSFRRMGVVVVGAQRSQVVNVKRIDRERKMLDLISSTLQAGGSVLMPTDPSARLFELLVLLETHWQFNRLGSQFPLCLISRTGKEAIGFVRSLTEWMGGQIASDGTEKLKFSNLRIFSSLAEIGSVIPPAVPKLVLTVPSTLSYGYSRALFLDFARNPQNLVLLTGLSEPGSLARWLVREIWEPQQDAGARYGQGKVGKEVKMDQTIELEAEEADAAEEAVTLDEQKMSSARRRRVGGFTGGAGAWDEFLDADTLAGSAGGQSFDIYVRGSYGIRSGTGGLTRFRMFPVVERKRRVDAYGEAIDVEGWLKRGQEDDPLAPGAQILGKRPREEEPEPEPEQEKPEPPHKYVVDRIEVPLQASVFVVDMEGLSDGRALKTILPQINPRKLVIVDGKREAIEDLANACRAVTSMTQDIFTPDLGETIKVGEETKNFSLRLGDSIMATLRLSRVDDYDVAYVSGVIHLDPESDMPVLERQSIADTTATPTLASEVETQAGGAAGEEASASADAVTEQAVATLDARDRSDGILTFAALKPSLFIGDLRLALLRERLNALKVPSEFTGEGILVCGPAPPEAFDYDFTSAAQRAGLDLRKGAKYIRDALLDEAMEASGGRVAVRKAGRGRLVIEGSPGETYFVVRKAVYALHAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZN3</accession>
    <name>A0A2S5AZN3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_7033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZN3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY69989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="334" mass="34632" checksum="485E496C85F4F548" modified="2018-07-18" version="1">MNALDAADLLTVRYAGQLPLVLASFPRLSSQLAQTRPAPTSTGGTGAKDPRHCTCCSYCGAETIGGVSGSYWVENGRLVGHCSGCRRSTLRRERVHASHTTTTTANEGKVAFERVKKRRRRAAPTLDYRREIQDEILHPTALLLANRRAAGSLPSSKVSSRAHSHSETPGPSPSSTRAETAPRVGTIRPGSTSATNTSSGSLSKRSNPDGAAAPIDSARASPLLGSSGLFSRASSVRPPTLNAASSRPPSRTESPAVPPGSMSASPSPGPRTGSESSTSSAIAAATTATATKKRKRPKQPSGLAGLLAQKKERELASTSAAKGAGGLMDFLQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B010</accession>
    <name>A0A2S5B010_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B010"/>
    <dbReference type="STRING" id="741276.A0A2S5B010"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="71913" checksum="28160FB82CDFABAD" modified="2018-07-18" version="1">MACSAWLVSSDSVLRTAVARYPQSCQNCTILRLLQRRKHDFEAERCRTARGARCRKLAGTQAAGPSLLQGRRLYSSGLQRRSIRSCGNMAKDGQRVISVVIVGGGISGIAQAVRLQEALGDKVDFKIYERADDVGGVWRDSTWPGAGVDVPIHLYSLYSHPNPDFTQKWASRDEVLAYWKRIAAQHRLHDKFVFDSEFISSRWDAAAQQHDVTFRNTRTKEPFTVSSHVLISASGALNLPKFPAAPGRETFKGQQWHSSQWRNDVDLRGKRVAIVGNGSSGIQIMPNIVDIEGIEVTNFIKSPGFFRPKENFEYSPLVKFLFRYVPFALLLYRWSTFQEYDWGLVLQGTGKYGSSLRQKRTKELVSYMKEQLPEKYWDEMIAEYPLDCKRVGYDAGWLQSFRRQNVELVSSPIKAVTEKGIETADGQFHELDVIVWATGFHVTDTGVGLSHGVFGEDGVELSEKYKGRGGAYGYLGVALPDVPNYFAVLGPNSIAMSWGYTIGNNTEFIARLVRGLYDHDLSAIVAKPAVVGDFNRYVQSRVSNSIWYSPECGDSWYKDPASQKVTVPAPWGATELWAQTRRIQWENWSCRRQGRDGHAREVDIQTPWNWTPIGFVTDWIAEWQRRKFESAMIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0W7</accession>
    <name>A0A2S5B0W7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000117">
        <property type="protein sequence ID" value="POY70423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0W7"/>
    <dbReference type="STRING" id="741276.A0A2S5B0W7"/>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="584" mass="61214" checksum="9E05CD4E4FA6D9BF" modified="2018-07-18" version="1">MIVSSNAPAPTKFSGRAVGCCAGALAGIFAAVFGVTATGSYAGVIGEGIGNAALTAWMSNTAQICQAILGPAVSLSSDMWGRKPFLLAGLTCAAVGAVVTATSHHPQVALLGAVLTGIGFSQQGLLVAIASETFPRNLRPAMQALFNISSSLGGVMGLTAGGLYVKSNVVGAGWRMIYGTLAIVYGLACVVIVFFYRPAQKRPDVSAVFRRHRYKIMAIDPIGLGLLACAVCPFYYGLISALNPYPWSDVHVLAPLCVGLAGFVCFGLWEWKGNSQGLLHHALFSRSRNYALCLGLLFTEGILFFSFNAFWAREVTVLLAIPSWEAGLNFLWFFLPSTIATPLVGWASQRYREVKVSLAAGFALFLVGSIGMATAQPSSRIAVRAFACVAGIGFSSPLTLMSVCAQLASPPELLALASVNLLVSRALGGVVAVACYNAVVKTRLAALVRPRLEAAIAGSGFPSARLPALVAAAQVPGTPGLKKIPGVTPQIAATVQTTMRQVYADSYRWIWVIAAPVALVAIAGVLCLEPIAPMMTRTIDAPADAQQAAPADEEGDMVGRRADSDDLKPEIEHIEAAPQELEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1C4</accession>
    <name>A0A2S5B1C4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1C4"/>
    <dbReference type="STRING" id="741276.A0A2S5B1C4"/>
    <dbReference type="OrthoDB" id="2536965at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="555" mass="61194" checksum="A82A903DE81FFC6D" modified="2018-07-18" version="1">MQSPYSPLDHPHRPERSPPLVPLPLDDAADSTLTYYEQRYTEAYDPRTRSQATAGYGGPYPYDTAAFAPPYLGHSHEPQPSYPRHFAPDAAYSHDDYYARTSPATTPYAVMPPDPYAAGASNAGPSSTYFPQHQHTPLHIQRHVDYYATPQSPYDPAVSTSAYRRSTAARGDGRKTSPASSGGGAPSPNLDYEVARREREREDVEREAGRREIEERERVKREAAWRRQSTRHERARVEPSSPEHALGVGYRTLLGDYADDAGPAGGLDVEEEDDDPAAADNLEDLLREVRGDLVPALVERGDRDRSDGGSGSHKGGPYAPRPWNVDPAPPAPDRRAYATSASNSPRRSVSSSTSSETLQYRLYGNTDDGPDPKRDNPPRASSSGEAKQDDQRPLKRARHGSSTPRTEDDGAESQSALEDACRLPRKFCADYARARELPLDAETRMADREPSLGEENKGQWSLFGETLHALTPATQVLMARAMRDITYSDRLRLYDHPEALAELERAVPWFTTLLTLIQDRYELAGSTSVAPQDPPPIAPTAEETLQDASESLSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1C7</accession>
    <name>A0A2S5B1C7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_6367</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1C7"/>
    <dbReference type="STRING" id="741276.A0A2S5B1C7"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="16"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY70589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="420" mass="45514" checksum="B86AD9E66B94BD4D" modified="2018-07-18" version="1">MADFTKQIEQRAQTINMNAGPSPLPQDALLTAAASLLSFQGSPGMGIAEISHRSKAFADVFNEANADLRSLLEIPDNYKVLWMQGGGLTQFAATVLNLNAWYRTKHQLSAADQVEGWYAVTGSWSKKAADEATRLGVKARKVVDGKKLGGGKFRSIPPGREWDLPQLEENQRKPAFVYYCDNETVDGVEFGGQGSDTEFPFSQIDPEVPIVCDMSSNFLSRPVDVSKYGIIYAGAQKNLGPAGVTIVIVREDLLVNVDEAVQYGSAPIPSMLSYKVMADDNSLFNTPPTFAIYVCSLVLRSLLESPPLPLAASAAPLSPLSDFADKKSALLYTAIDESAGFYAGTADKGVRSRMNVTFRINGGDEDLEKDFIKQASDLGIKGVNGHRSVGGLRASIYNAVSLEGVQRLADLMRTFREKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1J1</accession>
    <name>A0A2S5B1J1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1J1"/>
    <dbReference type="STRING" id="741276.A0A2S5B1J1"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015374505" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="18"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="646" mass="70954" checksum="F4CE75EBCA3B2D17" modified="2018-07-18" version="1">MRRSAILAALLPAAASAFYLPGAAPISYRNGDPVELTVNALGPYGDWGGYGLNSYDAYDERIPFCQPKSLHSQTLSLGSALNGDRLYNSEFNLRMLRNESCQTLCTTEILPDQTGFLETLIGHYAHRWLVDGLPAAEIRGDADGELFYSAGFPVGERRVLPLAPGAVEADADLQFEHRLNNHFTIIVEYHPRPKEGVNRVVGVLVWPQSIDSLAVGGSTSPPDCGAQRPFILAPDEAQSRPVSYTYDVIWRESAVPWATRWDNYLYVSSARIHVLSLVNSLVVCLFLCLVVAAILLRVLNRDITKYNSLSGGYGYDLSIDPDEQVQDDSGWKLLHGEVFRAPKYRMWLCITVGTGAQMAAMCGVTLVFALFGFLSPSNRGALSTVMVVCWTLFGFVAGYVSSRLYVTMRGDAIRKNIIYTALVFPSVLFAFLHLLNFFLVGLGSAGAVPFGTFAAIALMWFGIHVPLTIVGGWIGVKRGALDVPTRVNAIPRQIPRTEWWLRPIPSALLAGLLPFGAGFIEVYFVLQSLFGSKAYYAFGFLALTSCLVAMTTALTCVLFAYLQLCAEDWRWQWRSFVNGAASGGYIAAYGLVYWASRLHLSGIANKVLFLGYLLFISGMSAIVTGTIGFGATWAFVRVIYSRVRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1K9</accession>
    <name>A0A2S5B1K9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000107">
        <property type="protein sequence ID" value="POY70669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1K9"/>
    <dbReference type="STRING" id="741276.A0A2S5B1K9"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="103" mass="11241" checksum="08175FE2AA0B7357" modified="2018-07-18" version="1">MVTVIDSLETFKTVIGGDKLVIIDFWATCKVISPVFEKLEAQYPNIGFYKCDVDEQEAVAAEVGVKAMPTFYIFKSGEKMGSIVGADPNKLKAGLEHHNATNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B225</accession>
    <name>A0A2S5B225_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fermentation associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B225"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="42"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="4">
        <location>
            <begin position="3204"/>
            <end position="3262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2407"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2449"/>
            <end position="2472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2409"/>
            <end position="2420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2452"/>
            <end position="2463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3271" mass="359882" checksum="2CF3D3AA883C2FD5" modified="2018-07-18" version="1">MLDGLVRHLFERDTNVGNLRGSGPPSLNWLFLVECVVVVILVLFYFFYISRLLGVIVSWQLRLALWRSTNSYFEIGAVKVSLLGGSIQFNDFRYISRNQSLRIVRGHIVWKYWLRHVRSEENKLSEARKPCRIQISLTGAEWFLYNRTPSYDAILDQLGVRDLFPTAEDDAVKRHLSRTSTEKSQGSLAGAERSHSALLDGEKGTGGRVSPDDRLKSERTRTDWLLEALPIEVECEKGAVILGNPSTPCILIAGFDTVVGTYSAVKARSALDPYKQVYHFNFRGNKVIWRTNPDYVGSMAECGQARLDELADRLSERTLLDLIRNPADLLSFSAFSELFRHKLFRLERPLKKKEDVANRRPTAERHAESGWTGLPRYQAAADPTAPLLSNASRPSLHPAEYAKVTTLLVTREIDMTYYVDVAGTVPSEHARKNRVAGLETHDVGNGDLSPEWGIDLVIRGGAITYGPWADRQRAKLQQAFIPATFLNGLETPRLRPGDQRLHTALKVFVEFSEGATIRVPTREPSKDWRYDDLDSTQDSVVRPYGWLDISIGPNSTMTYLLPMVATMAGYDTLLELHLDEVGLSSSVNYAPFLQAPACRIHCGLPSPLVWDEKRVWTVTTRISKPDISLLRDHVTLLSDVAKDWTSGPPGDYDHFVPFLYELHVEVVDYVLQLYLNDHNIINNPTTPEDNALLSLSGPVLTSRVSIPSDGYRAECTQMHFDVDMTDVVLSMALPDWNTHRAFMTERTRTFASAPHLGIAGSYRFYAQASADNVEKLDLQITSRDVMFKAIGWFMRYLLNLKENYFGGFTHFVTLEEYRHRHERNLQGDPLELKYRPGKTDAFEVTVAYELDGGLLLLPQEIYDCQAAIVLALPHIQLDLRNHDYFMEMALNIGPFRLFETADCSTLERSGLSRYYRAAEESVHVNGLEITANRLFGPQPRTATYMCIWSFHLGQTVGSVALPFLQALSRAAGSVGLTFADSDNSLPPDFAIRPDPDATFLSVTTGAFDLSIGGARSACQVTLPKGFDLRFDDLASAPFLKHVCLDLPEVHVKMLAPLHAHSGRWLETASLRGDLSAAVGLSIAGWEARAREQLSFIAMQDSLTRRCRFVYGDAQEGAHRVGNLYLPPLEAPLESPHSTRTLQQREDGNDDDCSVPAREDNNSVYDDDDDHDAAENTTDDSVQGGRRFAYASRLPLYARSKERELEDQGTFRRINKRFTRRPDRDTTAALPGPKARIRDFGVAEFISVPDKRTCVDLRSRGGLRATMSPLVCEAIDNLIEDLHVDVRPEHVLDDLYRAYLDKRPRIEEPASNAFEIKLRIPAIGVTAVQDVLQSETPSLSPHGGDRDGQRPGPENSMFGVIRLDIIDIAMSYRDLTVSDISTVSLSSRRTVEHVLAAHAEQSQLRILRSSTPSVTVPHRTIGTPGLGHDALVLYFRRCEARLDYTLDRVLVGLIGGSATLDFDGEAAGLLIGSLWSWRTLSEVVDTLSARAVDSKLLVRRLLADIAVEGESAGALAVPTFLNRISYLAGASSTTRLDDIWKLLHILRQAHRHSRKSIERPSDIRWPPEEDRDRFLRAISAHANWDLDVADIQASAFVRGVFGDDEGADPIATAPSALFWLHPFALDWTTETFQAHFWHNGRRTNRLALGPTDALIGSSGVLPGADDLNIRARLTLHSIASQVDRDLLGLVRHIASVRRTFEDRIKRFQVALRSARGQPAPDSSPSAPSLPWASLPPINLSASTAVLRTAMKADAGEVTAEAAGSAIISSVFVHLQPRLEQDGLFTGHSWKVAGTFAAESASLTAAEGGRSRDTLLSAGVVTSLHCLWLEGERAADGQIAVSSTRLNASVGGVKLRVPRDAVRSYQFIDNLRATTLPTYDSLLSELRFDSAVKAEAPQGGSDRNNGAFDAWAGSPLRAQFVCRDLVVTIQAIATLETSYRLERLSAFANTAIAESEPTELAATHGGVHIGRQSVRFVPLLSETAHGSANDIPAETVFDLPIIRAVGRFIQRPDQLLRILVTVDPVAITLTAAILDSILAVQRHFGHDIDELLSTVRARRIAPGSPTPMAPHSSTTPAPATKVSYDVQLAFRGLKLGVQGPQAIQWVGVDLLEGHVSSTPASPRLLCRAFLQDLALSLEQRVEEDESRSLEPDRRRRHRLAFFRLDLDADIVPIEPKEAHTPLGNASSTLSVNVRVPRLEAVLQPASIEALADLIEHFGVEIRLRRQSREAEIESLRTRVISTLDSESQGVKATSPLATCLFSVQASRLGIAIPLSDEGITGAVATRRKRTRTTQARPAFLLTLPSLSFSAQKGSDCDAQIARFSMQFVPDFDQGRIEHFEGDWHRSHNRVVLPDARCTIRIANTGLTTVQSKVSGLEVDVDADIVSFVYALTDVYRLSHQRFAKYADELPGSSSGEVGTSPSFGPLHQPHSEPRRIHADFSFASGVIRAHSEESTATSTETVLATGRPRHQRRGHSISDFAGLHRHSEHTIAEPSPDVFHLPALSVWAHYEDDSEVLAEPSQKAHVDLVIHQSSNILYPSLLPFVTNVVRQVKKRQRVAETSVPNTPALGEELKGSELSAPPVIPAQDALSNLGLSLSLRIDQSKLEVSCMPAAEVMGQISWVSGGFLLTLVPRSGDVTITATVDGVSATLRHLFSPEDCIRAETRGLAVAASYARPDTTSLRGILSVLVRVPDTSIAVNARHLQDWLCLKAIWIDQPDFGPFGTVRQTSARDSKLATSGPSPPFASAQIETLVRLEAGRCALSCDVGPAIGKWSVTADDFAMRVCLRPSSTRDVAIGLGGIRIVGQGRAGGVVSLAGLKFSTRLRDDQCMGGDKFSAADLLHIEIELGKIDAAIEHDFHRILVFASDPLRVSVGDDWSQARAADPKLQLGFQVKAGSLQLISTTATVPILLGVSRRATALLDEKSSAAAATLIAAGFKPRESSSAKAATAVSNVASIFGGDSDSHTSARTCPVRIVNTLSIEIDSLRLAVFADHWNDGEVYRADAGASIRAELLRGVDANQVIQRELRLHLGYFSIRKVNHRRVSPSQESDFDVTRWYEYLRTGSERNIFKIGTTDVAMDSAQVVGSNRLKHRFSMQFGGHVDVALNYALFRNLVTLSNQYQLQLDRVMGPAPEAVAPPKASVHEGGTPVLAPSAVLGTGHDETKTTILRPELPSPEGEVVRMKPLPAIQAGKAERRALEFEALEMEVHQPQLQVLGDATPPLEWLGLQRDRFPAFVHTGVTSPLEELLIVLSSTYSSQLARTKFSAARPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B237</accession>
    <name>A0A2S5B237_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B237"/>
    <dbReference type="STRING" id="741276.A0A2S5B237"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="274" mass="30539" checksum="3472AD154E92A7FA" modified="2018-07-18" version="1">MTEQLPALHALTISPVLGSAATDARPPAESPLPRSDGAPPEPTARRSPTPRTKATSSFERYDGPITYRAYRGEDDIDAIFDLVDDELSEPYNLYTYRYFLDDWPHLCFFACADDRPIGVIVCKQEPHTKSAKSAPIPDRPGERRPLMRGYLAMLSTKKEFRGRGVATHLLRLSLSVMLRPPPDFVATLPPSHPSRQPVDEIVLETEADNSAALAFYAKMGFVREKRLHRFYLNGKDAYRLRLDLSLSAPVAKDESSSVRPRTDSPTEADPQSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B288</accession>
    <name>A0A2S5B288_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Teichoic acid poly(Glycerol phosphate) polymerase, or putative RNA helicase</fullName>
            <ecNumber evidence="11">2.7.8.12</ecNumber>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZCCHC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.12" evidence="11"/>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B288"/>
    <dbReference type="STRING" id="741276.A0A2S5B288"/>
    <dbReference type="OrthoDB" id="2529423at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052115">
        <property type="entry name" value="NEXT_complex_subunit_ZCCHC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316">
        <property type="entry name" value="ZINC FINGER, CCHC DOMAIN CONTAINING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="283"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="469" mass="50264" checksum="8D1AC6C834A88886" modified="2018-07-18" version="1">MSDSAVRACFPLTTGPSGRKRARTRSPPPGSNVPPAKRTTQSRAVPVTPPPASPDADDPPLFLVTASPSAIVDDSHYSSFGHGFSYEYHGADLSRHGLGEALVPLGEQASKQESPAAVNLNHLIPVAACFNCGSPGHQLSDCPFVCDQATISASRERFRSEKAELSALGSVPSRRLGAITVGSDSPHQRFLDYADRFKPGVVSDELGSALGYGADADRFVTREYPWMYRILEYGYPRGWTMRAGDQDPFSRIRQHVRRIAQEFGRSDALDTLDDVSDLVVYDGRGCPKPTPTAMASSSQSRPTSRAGSPRRQTSPTPPASAQVHTSRSIGASADAQAEPFSRGSSRNESRARTPSSPLHGSAPLPSLTPPPLPVEPPPPLPVEAPPPDDPPPLIRLVDFRTALFDSSSHWLAFSPEEYYSSFNRPPPPEGRETQRTGSCVETKSSGVSGRGESEAGTEDMDMSSSDESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2T2</accession>
    <name>A0A2S5B2T2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Retinal dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.36" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2T2"/>
    <dbReference type="STRING" id="741276.A0A2S5B2T2"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001758">
        <property type="term" value="F:retinal dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="75"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="553" mass="58859" checksum="4E0090D9BDB2C42C" modified="2018-07-18" version="1">MLRTASRTISLSKAARALPRVPTLATLARPPAARLPIPSYRRGFASQSTMPTTASIQLKSSKSDVPTGVFINNEWRESSDSSTFEVLNPATGAVLTQVAHGKAADVDEAVKAARKAFKTTWGKTVGPEERARLLNKLADLMERDIEVLAELESVNGGKGVRIAREMDIADTIGCLRYYAGWAGKVAGETIETTPKTKLAYTLLEPFGVCGQIIPWNYPIGMWGWKVAPALAAGCAIVMKPSELTPLTALYLCNLIAEAGYPAGVFNLVPGLGATAGAAIASHMDIDKVAFTGSVLTGRKIMEAAAKSNLKKVTLELGGKSPVVVFPSADLEQAANWAALGIFFNSGQDCTAGSRLFVHEDVHDKFVELLVQKAQACAIGNPLDEKTSFGPLISAQQRDKVLSYVESGVSEGATLATGGKKWNADGNEGFFIEPTVLSNCKPSFKCVQEEIFGPVASVLKFSSEEEVLELANSSIYGLGAGVFTNDAKQAMRVSGELSAGTVWVNSYNLLSNAVPFGGMRQSGMGRELGLAGIKEYLAVKSVHHNLGEDLEWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Z8</accession>
    <name>A0A2S5B2Z8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="8" type="ORF">BMF94_5472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Z8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Z8"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="534" mass="56980" checksum="84C8BDE52DB6641D" modified="2018-07-18" version="1">MSQHASYLVREFLEATQWNTWDNHYGTLTQPSRQLLDFAVPVGVSVTTASHPTRSLAPSLTLATLVPQHDLGTQPTYPPTPAPTLGGPVNPLLAGQLAYLFTSAPLGHLCSKRAAQGSDRIAFHNVTQSYPIGALPVRPELRDDARPTWHAGRLTTAKDYLLYGRLYAPSPRLDALYIRRISPTLQGLVSLITVPSPAPPPTLTWESGDPTASLSASATTNAAAAAAAAGPTSGPLARLSELELKLQHDTGRWSTEYSYAVGDGMWGVRGLYNFGRHGDPGGMNTPTPVAPQAGGAGPLELADEEAAAMREAAGTGAGAFGGLAQYDETPTGLKGRWSAGGEIYFSAQERSAGVSTALRFVTIPESAGAPSNQPPTYVTATLNPIMGQLSTAYAVQADRDTRFASRFDFNLYSYESDLTVGAEWFQRRTSSREASAKGKAKAPDQDAVDAPFDAFGRGTDDEETRKRRMNHDADDEVLSVLKVRASTTSDLALLWEGRMGDFLVSAGVVADLRLAMRGRMSPIRSVGLGLSYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B339</accession>
    <name>A0A2S5B339_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B339"/>
    <dbReference type="STRING" id="741276.A0A2S5B339"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="282" mass="30043" checksum="00EC9E374054FFCF" modified="2018-07-18" version="1">MHVVRVSGLPTTTTKDTLDHFFSFCGKIHGIEGPSDGKADISFAKESAAKTALLLSGGTLEGQTIEVTSDDVEPPKVAQQAQAPMPSATTTIGEHEPLNQEDKPRSAIVAEILAEGYTLSDSVVQKAIEADKQYGISQRFLSFFNPLRERVGTQAAPTIDKASTKARELDEKHGISLKAHASWIIGEKYYKAALHSSLGQKVNSFYTTVAKEIQDIREEAKRIAENKKANSATTAGSGSVPTTGTATSTSLGKDAPLPSVGTYGEVDKDLEKPLESTAAPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3J7</accession>
    <name>A0A2S5B3J7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3J7"/>
    <dbReference type="OrthoDB" id="10553409at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="168" mass="18218" checksum="6F2550EC42469ED8" modified="2018-07-18" version="1">MSGRPERTASRARSSDGGTSSEDLTEYELPLLPDLTATRSPTERFRRVDTALAFLGTGCLGVGSALLIAFYVTGPPRFNDLASTTTVVLLLTLVAGLASSLPSWYMCTEVARRQSRFADAGWQASSCVDAPWQKTESGRCAATRTGSENCFAARTRMSCRPWRSKLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3S4</accession>
    <name>A0A2S5B3S4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3S4"/>
    <dbReference type="STRING" id="741276.A0A2S5B3S4"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="55"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="246" mass="28007" checksum="6CEA4571EF641BA5" modified="2018-07-18" version="1">MPEHAHLAVKIAREAAAEALADRLRSAYNDTHGRGKDVRQIRGAVTSLITVETFATISEEEKDWVWRLFEGNMRSLYEASSEGYDANEKRSELFHPESRFLTLRQDTRPPLGYCIFRFDTEETASEDEDDDDLCDVAYCYELQIEPGAQRQGIGRILMDALGRLAGAFKMDKTMLTAFKHNSDAVTFYKRLGSVDRQADADVRRLRVQSLRLTSLRTATRFETDEVDPSQYGIDDVDYVILSKSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3S6</accession>
    <name>A0A2S5B3S6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3S6"/>
    <dbReference type="STRING" id="741276.A0A2S5B3S6"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="536" mass="57733" checksum="4FBBA5A3380871B4" modified="2018-07-18" version="1">MTTTSVHPLSGFGKAWPVPDFSLEGRRAKASTTLPVGLFILGDSRSPSTTLKHPDEEKGRSLRSSSRSTSTNGLFASSDAVNRATSFAAGGAFIQPSFDSVRLPDALLQSTDDDADDSFLDSWVNSGGARAAAAADVDSASAARRSPEPAPLAWVPSSWTTAIDKAVMNANGCIQLSGNRLEEIPSLVSDLANLRAFEPRISASPFSRTQSSPAAAFHLRRSSGRTSSGSFGPTTFASASPTAVPVELHLGNNDITVDSISNSLWTLRNLHVLSLRQNRLESLPEGIGRLGSLHTLNVASNRLRYLPAEILQLENLAIVNLHPNPWLAPPAPSAPSSPDPDASPASEASPRRRRLLGPLTTHFKQPALKEVALRRLLAPSQPTATDLAQPLVKEYYTPDSMRQLEVPDHLYAYFLTVFQHTSSTASAPFSRVRQSSTSSTLSNASATVPTIAPFDPLSHVCHSLAHAGEPRVFVEPAVERFEWVSEASLKPASQQSTTKRALEARNIPLRWRGCSATCLDWLEEDEEELESESTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B440</accession>
    <name>A0A2S5B440_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000084">
        <property type="protein sequence ID" value="POY71515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B440"/>
    <dbReference type="STRING" id="741276.A0A2S5B440"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="224"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="443" mass="48056" checksum="97CA0E773F97E27D" modified="2018-07-18" version="1" fragment="single">MPTPISTSPDRVATSRDRRPALGSRVASALTGTTSGSATPSTSYGSFPPKNGKTNAQDGGENEAAVKAVEDLLRDKLQASPGPARNRVRLEPGTAASSSERHGRLGSKRRWTRSRERLLMRDDRGQTHDDVYDSDAGTASDPENGVLARDFHDFTDQGDDVDPTEPWRTVNGKGRPSSPPDEGFLRSRRPSRNGKDERRSSGDEDKQWGVVKMELMAKTWGRKGFLTVYAGVYLISALISLEGNTTPTIEPYFLSLLGEHSMLSSVVIVMSIAYAVGKPPMTKVLDVFGRAEGVCFAAALYSLGYLITAGATDVKVYVFARALSALGGQGIQLAQQIIVADTTTLSNRGLITSTVSLPWLVTTWIGPPLGAFFQRRGPAGYRAAYAVFGILLPLEGTTLSARERREASAAETAAKEMTRRKRWNMSTWSKAVELWKDLDVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4B7</accession>
    <name>A0A2S5B4B7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4B7"/>
    <dbReference type="STRING" id="741276.A0A2S5B4B7"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
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    <dbReference type="Gene3D" id="1.10.10.10">
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
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    </dbReference>
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        <property type="entry name" value="Myb_DNA-binding"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="7">
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            <begin position="129"/>
            <end position="226"/>
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    <feature type="domain" description="SANT" evidence="8">
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            <begin position="381"/>
            <end position="433"/>
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            <begin position="385"/>
            <end position="429"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="275"/>
            <end position="314"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="491"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="48"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="675"/>
            <end position="685"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
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        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71629.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
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    </evidence>
    <sequence length="685" mass="71924" checksum="3ED2A3AEA83FFDFD" modified="2018-07-18" version="1">MQADTSMSGQANESGSATPQKRSVDDDLVPASVDPNNNDASDATAAAPDTKRQRTEESNAPSNGTPAPPASAQASGSGGQGAPPPPAAVDEDANQKTAEAAGMMGDDPASVQKRMTTARRHLAAQTHPVIIPSYATWFSLAAIHQLERRSLPEFFNGKNRSKTPSIYKDYRDFMIHTYRLNPSEYLTVTACRRNLAGDVCAIMRVHAFLEQWGLINYQIDADSRPSALGPPFTGHFRILVDTPRGLAPLHPGSSAAGTSSAAAASGSVLRTDLIKTDPSRPAQPDQRLSSTSAASLAQEAARSQSGGSIPPCHTCGATTPTVRYTALSTAAKQRAAPGETLSICGACYSEGRFPSTLHAGDFVRLDADPFGHDDGDAAGGSSARPWSEQEILLLLEGLEMFPENDWDRIADHVSTRSKEACIAKFLRLPIEDQYLAEAGGVPNGGPYGLAKVPFGKTDNPVLSVVAFLAGAVEKQVAAKAAGEAIEELEKSLKSEAGKSEKSDAMEVDADGQEKGQNGADGADAKPATTDAGSEGALVDSSRTSSRANVRKAALTALGSAAAKAHALALEEDASLHALVTAVVEAQVRKLDLKLKHFDELEALVEAERRSLEVQKQQLADERLRVNRLVGEAASLLQRAKENPAQVQPIEVQQVAAQMGSAPPRAQPVENPGPAPAQTGPAAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4F5</accession>
    <name>A0A2S5B4F5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_5357</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4F5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4F5"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="204"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="455"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY71662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="629" mass="67259" checksum="DD16F51ADF80B603" modified="2018-07-18" version="1">MSKADLTPEQAAAKAARKAEKKARKAATESAATSTAASTANNSDAEMTAPAANNADEDEKARIKREKKEAKKAEKKRKREQDDASAPSGTATPAEQPQADAAENDQEERKSKKAKKGKKSEGEKTDSTAPTPAPVASTSTATGPVASSAEVEAFLKENNISYDPASTSTALPPVLSFAALPLDEGVRKGLSGFAKPTPIQSASFPLMLAGRDVIGIAETGSGKTVAFGVPAIEHILSLGSFGSAPSGNKKGKQAGGAPVSVLIICPTRELAMQTHQNLALISKTTSPAVPSVCLYGGVPKPEQIRILRNERPRIVVGTPGRLLDLANEGNLDLGKVSWLVLDEADRMLDKGFENDIREIIKLCLPSPQSQLGPIKEEKGEPKFRRTAMFSATWPTSVRRLASDFMTAPLRITVGSDSLTANSRVEQVAIVVEDGRQKETLLLAHLRDNGFSLNAAKKKGAGEGKDRDKALVFALYKKEATRLFEFLQRKGYEVGCINGDMSQDKRTQSLNDFKTGKCNILVATDVAARGLDIPKVELVINQTFPLTIEDYVHRIGRTGRAGRTGKSITFFTEADKALAGQFIRLLKDSNAVVPPGLDQWGTTVKKATHSAYGAFYKEGVTGTAKKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B508</accession>
    <name>A0A2S5B508_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B508"/>
    <dbReference type="STRING" id="741276.A0A2S5B508"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="560" mass="57840" checksum="C285DA042AACCCA9" modified="2018-07-18" version="1">MSSTDDFDREVKALVTRGKLSSSAVASLSDLAMANIRADSQLVSTLYRHHRKASPANKLVSLYLIDAIAREAKSRQKKAEREDKGKAPAAGSTTPLDSPPEAGPSAGNGDFATFLRKLEAVLSKIVLDNWENGLPEHREKVRKVLDIWTKASTFSASALARISTKLLATSTAIPTNRQSPGRPSLSPGPADTPPLETANSQPGGAIPASVLALLQAKTAPSQAALEQQKHSDVESEVERALREAREGASSILTPVPTSSNPAVPSQPAYLATQSGSSYGAPPHGFSAQPATSRPPHHQAPYGGSASSSLNAGPPAYSAQQPPPSQAHSPPNGAGQAFGSFPAQGQQQGPTTHRRQDSHNWSGGDRYNSTSDATRGPQGAPSFAAGPSNAPRGQTRPHDAVEQSTPGSGYGQRDEPPNKRPYQPEGTAPVAPTSYQTGLPVPAQVAPIHGAHPAHPAAPPFDPTTFDATSPASWSAFVDALKIAHPYFATIGRPPTMEEVMGMCAPSAMMAFGSAAGSTGGPAGMAMGQGTVMGHGMAMGSGAPVGQGNSYQAGLGQSQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B555</accession>
    <name>A0A2S5B555_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000070">
        <property type="protein sequence ID" value="POY71908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B555"/>
    <dbReference type="OrthoDB" id="5544050at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="159" mass="17339" checksum="D484DBA48BCFAC33" modified="2018-07-18" version="1">MSNSPQPAPVASTSTAARATQSPQPQSKLIAPPKRIEPSAATAAKPKNLFSNDGSFLERFKKAAVPTPDQERKEREEALARKKALEDRFKNRGKRPAAGTASGSKSTSPGVEESDPSKRRRTTGNGDADRPLTEYEKEVRKLEARHLKDEGSSLRSLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B584</accession>
    <name>A0A2S5B584_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000065">
        <property type="protein sequence ID" value="POY71940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B584"/>
    <dbReference type="STRING" id="741276.A0A2S5B584"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36403" checksum="5E78A09F257B6ADF" modified="2018-07-18" version="1">MASTAPATTASRASSQLPPYDIIGRWRHFASITSPLTLLASSDDLKRAQQLLREYQDGQGEGWKAWGHEDQYGVWKAKQLVDSSIHPDTGEPVPLPFRLSAFVPTNLVIVAGMLMPNPSLKSVIFWQWANQSLNVAVNYSNANKSISMSTGEIASAYAAATVASCSIAVGLSQLVPRLRVSPAARSLLGKLVPFAAVASAGCVNIGLMRWKEMRDGISVFPPSDSQTGRPNNEVLGKSSIAGTYAVGQTAASRVLTNIPTLILPPIIITLLEKRGFFNRPNGKRLSTVTNLGLIGLSLLVFLPPAIAAFPSRASIDPKKLEKEFHEVPYDHVEFSKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5D3</accession>
    <name>A0A2S5B5D3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5D3"/>
    <dbReference type="STRING" id="741276.A0A2S5B5D3"/>
    <dbReference type="OrthoDB" id="3224367at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="358" mass="39021" checksum="D721DA6B8AEC2DED" modified="2018-07-18" version="1">MASPVASLDLLDLFPIASTSESQPVTVEGRTLGVVGPFPVSSILHLALNHLRDSIDDDRGISTLSQRARGKQRDSSQDGNDSADGEFDEESFLDRLTREAARATATDRRGYKSVLVLTGDRERLRTSLVDQFDDSLAGEHVGAHDLALLDKIDIRYLPTSAHLSYFLSAAYDETDQNFAASSATRPSRDPSLLERRPSLVILHDPSTHANEPAFIDAGISAYAAIVAQFCATFEKAPLSPLLAIFESTDPRQLAPILPRHLRSGGSKAGQQVADRDALSLCTVLERFCDWVGTVEAISSPESPTDGTSGEHQTSRGFIMSGRPSPRRPMPDQMPTGLEYRVHPADETRNRGSRIEVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5G6</accession>
    <name>A0A2S5B5G6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000062">
        <property type="protein sequence ID" value="POY72017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5G6"/>
    <dbReference type="STRING" id="741276.A0A2S5B5G6"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="260"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="714"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="740"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="757" mass="82809" checksum="212B54916ECBFCFB" modified="2018-07-18" version="1">MANVSSSLPPNDMSTTSSETDRTLTDSVAAAQNHNAAAPSPGSGSAAGHATHGIAAPITTHAHPALHPHITKHVPAAAATDEYYNTDEAQREIRDWGGDAPTDLPAIIPKRKRGLSSAAPGSGGGGGGGALAGVNAPHQAPVYTKPTGEVVDARAGAPIRKRTRSGTVWSEGGYPELTHVDTAFSDAHRAFSRLSRQRSVSARSARRSSDTSQTRRDSEEGEENEDEEQQENRKDPNKVEWEENDPHNPQNWSVRYKWIVTILCAQATLVVTFASSAPSSATQQVAADFNAGREVSQLITALFLAGYVAGPLLWAPLSEIFGRRPIFLLSLGVFAIFQIGCALAQNIWTLAICRFFAAVFASSPLTNAGGVIADIWDPVRRGDAMALFSASVFIGPVIGPIIAGFTVMNQSLRWRWIFGWIAFWGVGSWILLAFFLPETYHPILLKKRAKRMRKENPEEHCDKYAELERADFSLKSIVTRTLARPLIMLAVEPIMMTVTVYLSVVYGLLYGLFSVIPIIFEQTRGFNPGEAGLVFIGVGIGTTLGAIISVWTQRGYPEQLKKWHGHPPPEQRLYGAMLAGPFLVAGIFWLGWTGNYPNIHWAVPAVSTIFIGMSFTLVFISFLTYLVEVYLMYSASALSGNTVIRSAVAAAFPLFIVQMYSNLGIGWGSSVFGFIGVAIAPSPFLFYKYGWRLRQMSRFAPCLDVGLREQVFEEERQENERKERGESTRRDEQDSGETSPTREKANEKPKAANDQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5J6</accession>
    <name>A0A2S5B5J6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4924</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5J6"/>
    <dbReference type="STRING" id="741276.A0A2S5B5J6"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="231"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="482"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="723"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="815"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="597"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="644"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="877"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="891"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="978" mass="104733" checksum="8BE767EF785E4C6D" modified="2018-07-18" version="1">MLGVDAVKRLGQALTTAAEQGKVKDCLKVLDELEKGVEPTEAFLKATKIGVLVNKVGRQPEGDERVSRAAKTLVKEWKLRLHKDPSIDKKAIELAASAGLPSAASDASSAASPSHDSPPVVDQEVPIEFEVMANLQPLGSKRPAPSLVESARSKPLPIPTKTVRHRKRSPPSDGSGGDKATPPPSKRVKTEPARAQQKGAEPAARTHKTDKVDLSAVFMATVNCPQKQFKTRVTACQALYDALAHGSDAAVDRLVELALDIEVAMWRKAEHDKGAGKAQQAYTQHVRSLYQHIRSDKTPWVRQQLLDNELIPEQLVEMTPSQFKTTEQRELDEAIQKQAMKEACFSTRSIEEEMRTTVMWRGGGSYVAKSTPPSTSSGLVSTSVPSATSTSGTTSVLSAGVAPLASPSTSRLAQSFLQEGDGELSSVFGSVLSPRDSWQCAACTEKFRQEEVIYPHPDAKHDTTKSEVFFCRQCFADRFRKGNCKKCKHAVLSDAPFVKHDGNLWHQECYACSYCSDPATEPVIDFAGMPSCEACFDAEAYKTCGIPPSPHLGQSEFFQSAPILPAPSKWGRPSLATSPVSSSSAANKSVWSSRAGAAIDATPKPGTQSTKLSRLQLERDNSPIAPSLNELGDKLQRVGLQGSPWRKPAVDTAQRSHPALNAPTMSTRRPLPTIPSVATDSPTAASTSRSTSPTKPSFVRQQHAPPSTPAAKPAPVRSPESRTTCTVCSAPLGDDEVVELASDGTRMHSACFCCGGCGEQLGSGRFIETEARWWHHACAPAPKRYRSIVTSLKEEPRGEAEEQEVEPVEPDADDAGCASCTRALGYSRCITVPRTGKMYHEACFRCAACTRVFKGGSGEKGFVEGKDGLPYHADCVPVSRVTPSSPQDGAPTSSSLPTSRSIRSLPDSHALPPKYTIPSSPTKAVEPSLFSRRPRPPAGLGGLLICAGCSVRATDKETVAANAGSAKMGSCGARRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5Z9</accession>
    <name>A0A2S5B5Z9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5Z9"/>
    <dbReference type="STRING" id="741276.A0A2S5B5Z9"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60829" checksum="E36CAA5F7BDD8CFC" modified="2018-07-18" version="1">MSAVVLDPMQNATLAGSAPPILPHLSPLTPTSTSVLAAIVAVAVLYALTGKRTKATLPPGPPGLPFIGNIRDIPKSRPWVKFAEWTDQYGPMYTLKLGRTNMIVIGRAGPAIELLDKRSAKYSSRARLIMTSELVSRGLRMTFMPYSDLWRRQRRLLHQLTSPAASSTYEPIQEQESTQIVLDMLNDPENHWPHCQRYAGSTIMQIAFNKRAPTCKDPAITRMRAINEMMTKTAVAGRYLVDSLPFLNWIPEALAPFKQEAHAIFDETLSLFKSHVDDVREAVAGGDDAHCFTKYILQQQESYQLSDNEATFLAGAMFGAGSDTTADGISTFIMTMVTHPEIQKKAQEELDRVVGRDRLPNFADQPDLVYIGAIVREMMRWRTIIAGGLAHCSTEDDTYNGYFIPKGTVVLANHWAIHMDPELYPEPQLYKPERFIKDGKLVGTKFSDLGHHGYGFGRRICPGKHIAERSLFIVFSRLLWALSLRPSVNPQTGKEEPPSVDAFSEGFSSHPLAFTCRIEPRGDWVREVVELEWREVGSDKGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B629</accession>
    <name>A0A2S5B629_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4749</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B629"/>
    <dbReference type="STRING" id="741276.A0A2S5B629"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001585">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="221"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="500" mass="51497" checksum="E9DD314F553C7766" modified="2018-07-18" version="1">MVGTHLLPPNLLKLFAPRPPLPYLKPTGRDPDFPLKSLSQRRAPKPILVSDILENVRAEQATKEAELDAQQQHHQDQGKVATATAVVKEEEEPKVVKQDSTEAQVKDDNNDVDMTTAAEAQAATASDDKEEGEEAPSATKEAPPSSTAAPVPSNGAPADEGKAKRLTEKPKGGAVAGERPDMTAEERVQLRRREKKRWQQECMAKPYAPQDDEEICGDPYKTLFIGRIPHEVTEKDLLREFDIYGPIDRLRLVRDPDSGSSRGYAFVVYERERDMKAAYKDADGLKMKGKRLLIDVERGRTVKGWKPRRLGGGLGGRIKKLKGGIPAPEPSPFPPPFMGGGGPPGGFGGRGGFGGRGGFAPRGGRGGFVGGRGGGFGGRGGFQGGGGGFQGGGGPGFGPPGGGFQGGPPPPGAPGRGGFQGGGIGYGGAAGAPPRGGYGGGPPGGGGGMGGPPPPGMYGAGGAAPAFGGEKRPYGDGPGYGGGPPGGGGGGGYEDKRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6B2</accession>
    <name>A0A2S5B6B2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6B2"/>
    <dbReference type="STRING" id="741276.A0A2S5B6B2"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="614"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114414" checksum="D81159AD0E1354E5" modified="2018-07-18" version="1">MQAMLVRLQFDPRAAALTPRLPTPDEFVEFLEHDATKEQLFMLKLANQLDTRERGARDIVINQLESVFQHTHFDLTRDDDGGNAALEDYRGTGYNTPLASTRRGAAASPVVPSGRPMKTKRLVPGIRNNTLQRLDRWILATPTNKTDREIYIRARQSLVDHIQDSQARGDQGKRLTDAEIRTAWDDIFHTMSDTNFSADVLSALRNSRPACSFLADRFVAVTADCACGECYDAGGHTDPDAGALYSRHDLDDEDVIDARFFERYNEQFDQTPSRPAPSVRATLLKKAAARRTGDGGITSMGNDSLLDLYGMRKPHSSTPLYQLEPIRFRDMQVPKSHKGSYLLCRIISRPTYRKCVHFVVEDQDGRAESLCLYNAVHDVIETGRALDELYKLGQALVIREPTFVRAVKGPTITLRVDSPTDVTFLPLSASLLQEATWTTESPSKHIEETVEWLRIQGNKAFSGGQHELAVRAYSAALALEPTPEELLVLALNRAAAYLRLRRYASGFRDASIVLAYLEQGVAGPPAAQSKALMRRATALHYLRQWHRALEDYSRLLELDPNQPTAVKNKAAVETAIGHSKTGVYFWNDIKIAYDLAAKTKSPPLDLLPIGDFVGPIEVRKMPHRAGGRGVVATRDIKAGEVVLVESPLAHCAPPGPFQRAAYDWKTGCLAEAAKTNLVNELARIIVDDPKMATSIYSLYGGKDHPPSGDLAFDMRENVEPSLFALPADADIERLEAIVRHNAFNLEFVSRTYVNYRESSECALFLGASAFNHECIGNAIWRPLAGNIAVRTRAPIRAGEEILISYIGLDAPLPLHHEVLVQHFGPGGKCSCMICSNEAEPTKVSERDALTDEFNELQDEVAHGGLTFSKRLSLRSRARVLVEKLEATYDEKSPDRFDLVGPMQLLAALMGMSTLSEYRAVVELELKRFAYAGAELSVRPTTCDVLAIPPIWNGSLITDLYRLAKRYVASGLPNPEREVRKWVRAAWTAARVSSGWDWDHFLRHEAMTLAVEGLHRYVASWTPPPWLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6D4</accession>
    <name>A0A2S5B6D4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4631</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B6D4"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="118"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="400"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="530"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="731"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="784"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="989"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1206"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1317"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1254"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="741"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1053"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1226"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1331"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1362" mass="149613" checksum="1CF3125E012745AE" modified="2018-07-18" version="1">MLRMARPPTPQPSERHGRNPFHDVSTTSASPTEDPRDQAEEVVTSTSEPEEACDVGSYGLRPARGEQDWYRFPAPTKDDALNWRPFLDIDTRKQREEEYTQAGIVPATVWKYKLIGEWRLGENLGKGTSGQVKLARSTATGQFAAVKRVFRLPEGMRHAHSIHQEISIMKLVAAHPHFVSLFDVFETPNYYFLVMEYSPLGELFNHVHQNIILPQMTQRFFSQLMSAVAYLARFRIAHRDIKLENIMLFRDEREDLSIKLIDLGMATYQPPGELLTMSCGSPHYAAPEIMEGQPYDGIKTDIWSCGVVLYALIARTLPFDDDDIPTLIGKVRIGTYEMPASIGGYARDLVQRCLTKDPAHRIGLSALLAHPYMVQASIDTAPPMSTNLHLEVMSDKRLARQVWVGGIAANATEEGIRHWFNTTIEECGFLSDGRRSPDLEEAGIEAPQPVVSVQFARGQDCAYVEFRNSEELEGALGLDGCVFLGSTLFVRRPEEAFWTREVENRPRPQAPVAQSHGATTADTPVTESAHKIFVGGLPKDLTEDEIEGVLANYGELRTFKLVRDPVTGQSRGYAFFEYADTKMTDLACTELDGMQICGMTLLISRTPPDTRPPAKEMLSYLREHSSVPSTASSGQASRRKQGLPCETDLEFPFPTYDHGLDDYARFVDPPRAVWDPDEPLDEDLVKDVAMLVTDNDYEGAVAEIREKDSCARLFYLVLLGFKQPGLLEQEKPVQPKSVFESSGPSSGSTYTSDGSTRRSSSAPTATFPLPPAVIEEDLVLVPRRSLPGPKDLVPDDVSTEAMSRKSTSRAVTSTSPRDGPTGRSWQEINQVYVFPAPSVRAEAPAETTAYGTAAPLASAPPQIETFAFEPLPISPEALAFAPSGHRMTRADRAGVMYSVPSSPALLQDFDHQSTGSEAAESPFPQRLRSKVSIQQRLRSIFSGPSLRQDAPAPLTQLGDLVRHTDEEIVTARQHRRKVSVNVRWSIAEPEEATTERKASSPASSRRSSLLKRSDAYNSFERARAGKPPVSPALQSFATLLEQGASAPSARSYKLSNLPPSQQPSFEVYEDSAADSEAPETPRASASKTKPLGSKDLVNTVDGDGTKGWRLLRKASSHVVGRVRGVRQLGLSRPASAAISNSTEATIRPTSEVPTVVIQAGTPARAQPTATIAYPWQSSSTDLAGEGANKPSRWRRASLSIQVPAIPPSETRISPSTSPAFDLSAPLTATHTDGSASAPNLAKAPPSPELLARSLELAQLENDHLRRTLDRQEKELGLLRAREATLADCLETGGKMVRELSEERDELQERLRRISWYSTGGDPAWLSPKPPSTRSNSATSGSSLETKWLGGSRKSRFEDEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6L3</accession>
    <name>A0A2S5B6L3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6L3"/>
    <dbReference type="STRING" id="741276.A0A2S5B6L3"/>
    <dbReference type="OrthoDB" id="2524982at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="82"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="480" mass="51292" checksum="48F72870B2FBD6DE" modified="2018-07-18" version="1">MSGEACDLVLPRSGSRHRAAFDEVVAAVPDVHPAYLLKLLNDLRYDVSLAVADLETSDYPLNSGGRKLNQAGTSQDLQQISPNVECQCCADSCAIANAARCDAGHGFCAECIRNFVENAISSQKPDLHCFALNTECQASFAPVELKRCITGNILDKLEQVRIDKEVSPLEGLVRCPFCPMAALLDDDEVVFACPECNVSSCRRCQKKAHGSNPCDKVPASQEEALDAVAEAMSASVIRKCPSCKVPCLKVDGCNKRTCGPCGAHFCYVCNKQTDKPGHWNSGGANNGRCPANEDSEKRAAEEAQEARKRKIAELEEMGVSVPSIAKTPKFGPSTPRRTAAQQAALFSNGRHVFRGQNTAFDFTPIAQAPQVTVEPPRAGPSRRSPARFSPAASPPRSWTDFDGLGWHAHEPAYGFAAAGSGVFGGGGFGGARTGTGSWHGGKGTRADETGDKDATPPPAEPEEVMRQRRLYAALARQGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Q6</accession>
    <name>A0A2S5B6Q6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Q6"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Q6"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="75"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="181"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="481" mass="51212" checksum="BCC3D1FF653FF8A8" modified="2018-07-18" version="1">MSASNAGQRRQSVSVSPNVAIVPNSPTQLAAALATSPPAISSFSASYELRRTANPPYAGKALAPFPVRQEPAKLLLLENINATAVKMLKDAGYHVEEIKKALGEDELIQKLRDGGFTAVGIRSKTKITARVISEVPSLLVIGCFCIGTNQVDLLAAARAGISVFNSPFSNSRSVAELVISEVIALSRQLCDRAREMREGIWNKVSKGCWEVRGKTLGIVGYGHIGSQLSVLSEAMGMSVIYYDVVPIMPLGSARQVDSLDDLLAQADFLTLHVPELPETKNMIGGAEIAKMKDGAYLINNARGKVVDIPALIDGLKSGKLAGAAVDVFPAEPAANGPNFGDSLNDWSSELRSCPNLILTPHIGGSTEEAQSMIGAEVGGALIRYLNYGSTIGSVNFPEVSLRPILHDGTVRLCHVHLNQPGVLKVVNGILGEHNVEKQFSDSKGDIAYLLADIGGVDEAEIKEIYEAISSSRANIATRMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6R1</accession>
    <name>A0A2S5B6R1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B6R1"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="325"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="637"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="843"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1150"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1236"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1321"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="968"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1152"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1168"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1269"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1404"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1431"/>
            <end position="1441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1441" mass="152362" checksum="06398995781AB325" modified="2018-07-18" version="1">MAAPSRPSLERNAATGLPPLLGLAKPGRRGADDDDVGDDRDEPRTLPSSPSLSRSGRTDSLAAIAANLDSPRATRPPLRATATSPPTSPSTSAAVPSTSTAHRAPAPARLSAASLVTHSSGGRPASSRESTLSSASGSIKSRHSARASPASSSSNTTTLASAQAQGTSRGDVGKDGFLVTSRTRHYVPPGGVTSPASPGPSTALMGANPFYGRSSPAGSRNNSRQNSRESSRERAAAVKREKREVDKLIRHYAGLGRGDRERGRSTESLDSSNGASGVAGEGGLGRRGSSPAILPTESRLADEPKTTRTLSSSIDSKGRRMVNQYVRLKTIGQGSHGKVWLCAEPSATITDEPEEYEEEGATGEGAEAGLDRNSSTRSKRSRRTPSQKWEDDIDAGKVQYCAIKSVARDGPRGQRGQRSLRMAAQERSKRPSTTQGSGGIGADDKVKREVAIMKRLDHPNIVRLKEVIDDAKSKKVFMVLEFMAGGQVVWQDDNKQPTLTVDESRRTFRDVVLGLEYLHYQGIIHRDIKPANLLWTEDHSTVKISDFGVSHVSEALLRASPDNDQTCEPDDEKALRKTAGSPAFFAPELCFPAEGSSTPGRPGSMHRDSMMSTTSASIAPTLSDAYFPLGMDGVQGTSPSAAAAPRTTSNGLPLSDVTISKPIPQLSSSRPRTRPPIGKGIDVWALGVTLYCLLFGDTPFMAHTEYELYNVIVREAIRVPLVMGRERAWTGVGQPWAGAGDGAEGREAVDLLSRLLEKDPTQRISLEEVKKHPWVLRNLTSPESWLRATDPARIHHVTVTDEDVQHATQERGAVDSLPPIRNRPGIRRALNAALAKFPAFSRMKSPRPAVSGAPEDPKSSERDARTRSKSNSSAAYSIDPTAESSASGVSRQPSDAGGAPLRAGKGKFSYDGATAQSGNGSGGGGSFGSELRRIISGGHAHNGEGGQAGTSPGHLSRGGWGSARRKLTPTNTLEPHSPPNASSLFPELARSTSTSSVGNGGNGRSGPMTGWFQRRPSDSDTSGLRSPVSSLPSPGPAHRMSMSPSPYAGSETETSNVNGKGSGTLSRMLSRIAHGPASGTGSSAATSATGSLHSKTSGRSEREPPVAESHVRALTADGIDPAIVEQFEAAGTNRAQYDSLGRLIAGRKGHAASRSSLRISSLAPGSFDDNDDEDGAIDLTDFEYSDSDDDDDDDDDDLDDLNEAPIGGANHLSGWQPATFGDFRIGVRSPSDERNLARGMADISSPLDTPPTDEVGPLDLYEEDGKIGAESTASAAAASRPQAEQQPSRETAAPKPVDTYVPLSDTVSFSLCPLDFDVDAWRMPPAPADPPVAESARAHARSSSVATRRDQAPLSIAPTLLPPACQRHDSSHSSQASQSPRDGSIRNLVLDTPGTTRKVAPQWEDAEDPDGDEDEEEEMLVVPRRRRAATLSGSGQATPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B723</accession>
    <name>A0A2S5B723_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B723"/>
    <dbReference type="OrthoDB" id="2530512at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="515" mass="56142" checksum="360C6CDE67243614" modified="2018-07-18" version="1">MGRNPFRTRPGGLSGPQPTHSSLGKAPGSKWGTKRAKPGQPIRRDGVFPDSDAEGAHRLASDQDSDFDSEQEPLATKSSSTKRRSAKSTAAKAVHAYSAETRTTSLSRSSRRRSVHAQSDSQDEEGDGDAALGADDVSDHDSDTTVGADSDDPDRPSYSRKKRMRAQNPTYKQARDARTAQRTPAAEDDEQERMRRIRAEAVARRLGLAGEGAGPVKSEKKQVALVIDDSSSEEDRGPPVASTSQVRLDSSPGSSRPVLSPVELRRTDQPRFMTLTALRTASKKKGSKAGARKKPKKGDAFYGSGNLLVSEDEIQADDVERDLEEYLSRKKRKVVKGAKADKGKGRAGDDALFRDDSSAGEGSDDDQDAVVARQLGAKKRDASSAGTNSSRSRGLKKNASASILSNEEEDDDDDDGGPPATKSSYSHLKIPKFVDPRADLARRKRLAELSSPPTSDFSSDDGGVDDGDRPGLNADVLEKERLELKRLKKVEREMKRKKQRYREERRPGYSNPRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7C7</accession>
    <name>A0A2S5B7C7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">INO80 complex subunit F domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7C7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7C7"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="4">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="238" mass="24598" checksum="CCA76CCC3B8C38BF" modified="2018-07-18" version="1">MAPAGSKSKAYSSGVATQADDAKYRQKYGELRKKLTQVEEDNTKLSVKILRSKKAIQRLRIERAILYDRLQSTVAPTNPYALSSAAHLSTVAQSSSSSSSANATQSGAPPSILQTPSYPLADPEAPTLFLRQLDAQKLAAVQHGAGADVEFGAKPFEGVAGEGKQAMEHRSLMAAGGDVEDDAKPAAADDGVPANGATDEADHAAVAAPAPAPAAPAAVPQAIEVSHAQAQEMTVDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7G7</accession>
    <name>A0A2S5B7G7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7G7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7G7"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme synthase central" evidence="9">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="8">
        <location>
            <begin position="188"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="335" mass="36174" checksum="129539EFBE6EBD35" modified="2018-07-18" version="1">MSGEYPLVEPTGSLLLAWQVSRESILLVGAGPVASSRLYHLVCAQPRKIYVVAPDDDNVDPEMRYRMTADPDAGAGGNGGVEIEWIKRKYSEHDHADLQLVLQDGQGGGGGGLGMVLVATDDATLSTRICAECRRLRIPVNVADVPPECDFYFGSVLRRGALSVMVSTNGKGPRIAARLRRRIEKSIPDGAGEAIARVGDLRAALRRVEPGKGNDAIAQRMQWMIRVSDQWSIEQLARMDPDMRHRVLQGWATDSAPSYYDVAPARINSLAALGLRAGRAVGLLGPGGSCPVDRDPDGNVRRCPFVLGMTGFVTGLVTASVAVAAWHRYSSMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7P8</accession>
    <name>A0A2S5B7P8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7P8"/>
    <dbReference type="STRING" id="741276.A0A2S5B7P8"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="75"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="275"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="500" mass="55235" checksum="D127D9FB51056379" modified="2018-07-18" version="1">MPRELLTVSAGQAGNQISGEFWAQLCAEHGIRPDGVVEDYPFASSSASTLGGSSALPSPSTASFGRQQAQYHDRKDVFFYQADDERYIPRAVMIDLEPRVLNGIRNSPYKNLYNPENFYSSPDGGGAGNNFAKGHAAGDAVWNDIAEMLEREAEGSDSLEGIMMMHSIAGGTGAGLGSYVLERLSDVFPKKLIQTYSVFPHMENSDVVVQPYNSILTLQRLTEHADSVVVLDNRALASICQDRLHVGEPSFAQTNQLCSTVMAASTQTLRYPGYMNNDLVSIIASLIPTPRCHFLTTSYTPFTSDKVEQARAVRKTTVLDVMRRLLQPKNRLVSTSFGSDAKSNCYISIMNIIQGDEVDPTDVHRSLVRIRERSLASFIPWGPASIQVALTKQSPYVRAKSAAEGTAPPPRVSGCMLANHTGIATIFAQQLQQFDKVRARKAFVTEYQREPMFEKGLEPFDEARAVVRELIDEYRAAEKPEYVDYGAPATNEAQDLRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7S2</accession>
    <name>A0A2S5B7S2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7S2"/>
    <dbReference type="OrthoDB" id="2522828at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="551" mass="59783" checksum="0FE34DBD06BBDECC" modified="2018-07-18" version="1">MPAAQDRFSSICPVSYVCPTVLPGSGDYCSAPWQYTGDTCCGLCPSPAIDAYGTVGGLIIGSFFNMLIVLFQPEESAAFIGGQLTLAHMYLIGASVLDQGETGAGGGAHLPSPRAAVLARNIMGTASEGTNGLQKWHAQYACAVTATVEMTSDDPGIEAGSFISSPLRSRAWCSLPFSRTRTTSMRVSRTDGFSSREALLDSIQANKDAAERRRQNPGLASEVQEQLVTTSELHLPRRRATDLRRALQRSRKGIGRHQAVIIFVAFAASELLWFISYGATIWWGNETKFWQPYCDDTIGTGSYALIKGVSFTFVSLAFLFTLFLIIPVFHPTSRYSSAAHFIVLLFSHHIVHPRETIQSVKRRGGNIRKRLSHAPGSPPHLGAPVESASNRAEQTVRVGLSLAVWTLWFVSVMVILFKALDGFLLVGTTMSAAWPYATIQNFMFGCFPLAKFFLKPVARRHGPGSRASADKEQSRVCGSIVERALSISAISCVVSIRVVIIVRRFDRPPSIPQSSSRKQYAQHSGHAKRGSGATGQSRSRVSRAATVTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7T6</accession>
    <name>A0A2S5B7T6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7T6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7T6"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="191"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="400" mass="45454" checksum="F83A05002027FA70" modified="2018-07-18" version="1">MSYPTASTSSGGGSQGQRDPETYLAQALTSPHLPSELKPFYEAFDRFWRNRLWFQLTRTIESFFAVPASQPFRIDLYEQFVRDFSNKLDPLKHASIAVSVARSYEDPRASIAFLDPLLPTFDKPETREAFVLATMERSHFRLRAGEYDAAKEARDQCEKVLDQLDAVDLAVHASFYRVSGDYYKAKAEFADYYRNSLRYLACVDIEKDLTEAERVERAHDLGIAALLGLSIYNFGELLMHPILDALKGTEHDFIRNLLYAFNAGDISKFQTIIPEMNAREPFLEQNLPSLRQKICMMALLEAVFRRATEDRATLPFSVISKEAQVPIDEVEHVIMKALALNLIRGTIDQPSSVASISWVQPRVLDRDQISGLKDRLSGWSDKVGAMGEFVRSEGRELFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7V3</accession>
    <name>A0A2S5B7V3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">3-deoxy-D-arabino-heptulosonate 7-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">DAHP synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Phospho-2-keto-3-deoxyheptonate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_4090</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 22">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7V3"/>
    <dbReference type="STRING" id="741276.A0A2S5B7V3"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="13" id="KW-0385">Hypusine</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="19">
        <location>
            <begin position="445"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY72835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="516" mass="55576" checksum="800DFB1AE8245862" modified="2018-07-18" version="1">MENQSIISDMSYQTAYEEYGDNLRIAAIEPLMQPALLRSEVPLSDSSKRTIAKSRAQVAEVLRGESDKIVVIVGPCSIHDVGEAKEYAQLLKAEMQSLPNLVVLMRAYFEKPRTTVGWKGLINDPEINGTFQINKGLRIARTLLAELTESGVPVACELLDTISPQFLADVVSWGAIGARTTESQLHRELASGASFPIGFKNGTDGSLGVAVDAMLSAAHPHAFLGVTESGLAAIVRTAGNRDVHVILRGGSRGTNYDSASVQSAVGQVKKISKPELPFLPAVMVDASHANSQKDHRNQPKVIADVCQQLRAGEQGIMGVMVESNLAEGAQKAPNGREGLKRGVSITDACVDWVTTKQLLHDLNEHQQTFEGVSAGASLTYPMQCSALRKNGHVVIKGRPCKIIDMSTSKTGKHGHAKVHLVATDIFTGKKLEDLSPSTHNMDVPNVVRQEYTVMNIDDGFLNLLTADGGEKNDVKVPDSDVGKEIETAFEDGKDITVTVVSAMGEEHCLAWKPTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7V8</accession>
    <name>A0A2S5B7V8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Squalene monooxygenase</fullName>
            <ecNumber evidence="4 10">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="4 10"/>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7V8"/>
    <dbReference type="STRING" id="741276.A0A2S5B7V8"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Squalene epoxidase" evidence="11">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="11">
        <location>
            <begin position="265"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="540" mass="58931" checksum="99D6125C9386CAFE" modified="2018-07-18" version="1">MSPSTTGAPRIPSADPQAAAEKTHDVAIVGAGILGPALAYGLAKSGRSVLLLDRDLSEPDRIVGELLQPGGCLALQRLGIDDALDGIDAVPCEGYQVFWGDQSVPIPYPEESKTMRWSDGSDAKKQEGRSFHHGAFVQSLRRKAQAVEGISLVEATVNELLENEEGTIVGVKATPRKSDDGAEQTPLDYRAKLTIVADGCMSKFRRALLPSHVTPITRSHFVGLVLEDADLPSPRHGHVILGKRDLAAPATDNSVEENPDAPSLGPVLVYQLATHETRMLVDIRGSKLPPQRDLAAFLREHVAPVLPKPIVPSFETALDKALSGDKAYRLRSMPNSYLPPYPQGRDAKGAFLAGDSLNMRHPLTGGGMTVAFNDAVLLTQLLGGGEPVHDVHGDERGPVDLEQWSDVTERLEEWHWKRKNVASCINVLSMALYSLFGADDENLEVLKTGCFKYFELGGDCIQGPVSLLSALKPSPSLLFYHFFRVAFYSIYCLFTSPLASRSPGHKPPVWQYPELTLRSFKVFWTACLVFLPVLWGEVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B867</accession>
    <name>A0A2S5B867_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B867"/>
    <dbReference type="STRING" id="741276.A0A2S5B867"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001135">
        <property type="entry name" value="ABC transporter F family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="191"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="536"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="755" mass="83814" checksum="C7547647F27C9A32" modified="2018-07-18" version="1">MATQLIQRVLPSLDFPILSYINGIFGSDADPNDNPVESFIRPLLESETRPSVPQDEIDRVCTDLQAMWDKATGGTSGAGGQAGGQNGAEPAKLDVALDMRRQEMKSKRQAVTQVVDIASVVKARESQVNMKALEKAEAKLKQKLEKRNARSLYEGSKLMEAQNNKKSYEELFLEVNPLNAIGTNKGKSKDIHIESIDLNFGSNRILSNATLTLPFGRRAGLIGRNGIGKSTLLRAMALREVAIPQHISILYVQQEVIGDDTPAVESVLQADVHRTHLLAEEAQLNETISSLEKEAEEVAAQGAAAGANEEESAKSHAELRKVERKKDDAMSRLGEVQKLLVEIDADSGPSRAAELLAGLGFSRQDQDMPTRAFSGGWRMRLSLARALFCKPDLLLLDEPSNNLDLNALAWLEDYLQTWPSTLLVVSHDRAFLNAVATDIIHQHNERLDYYKGNFAQFYATKSDRQKQQKREYEAQLQYRQHLQAFIDKWRYNAARASQAQMKIKILEKLPELTPPEEDDVVTFKFPETDKISPPLLQLSDVDFGYTKEKMLLKGVNMDVGLDARIGLIGANGAGKSTLIKLLIGELQPIRGQQSRNGRLRIAYFAQHHIDSLDLTVNSVAYLQKLFPGMTEQQYRQHLGAFGITGMTSLQLIGTLSGGQKSRVSFAVLSMQRPHILLLDEPTNHLDLEGLDALMDALNVWNGGVLVISHDSTFINTVCKELWVCADGKAEKFYGDVDKYKEIIVSGNKTMRPTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8C3</accession>
    <name>A0A2S5B8C3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8C3"/>
    <dbReference type="STRING" id="741276.A0A2S5B8C3"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="182" mass="20479" checksum="E5CA30CC791158EC" modified="2018-07-18" version="1">MAIQNLIAFGILTCELVTFGVLIVPLPFTWRRALFKAIAESHIIAQIQYGLKITFIFIALLFVDAVNQMLKIHREKEINAAAGGAGTIPDMRTQSEYRSRKFLSERNFYLHGSCLVFSLILSRTYSLVLDLIRAQEELAIIKAQAGNAEAAKIAPKDEKDSIQNLEKKKVKPSTVRKEDKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8E6</accession>
    <name>A0A2S5B8E6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8E6"/>
    <dbReference type="STRING" id="741276.A0A2S5B8E6"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="211" mass="22351" checksum="77D8B0E65ED31688" modified="2018-07-18" version="1">MASNSAPAPNAAVAPPVTSSRKLVLLGESAVGKSSLVLQFVKGQFDDYRESTIGAAFLTQTIWDTAGQERYKSLAPMYYRSAHAAVVVYDITSAPSLQKARSWIAELQRQADPGITVMLVGNKLDLADQRQVSTEEAQKFADEEGLLFMEVSAKTAQGVKDVFDQIAEKMPIDSPASQRSRTGGALGGGRGHGGVDLKQGGVKSLTDGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8G0</accession>
    <name>A0A2S5B8G0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_3885</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8G0"/>
    <dbReference type="STRING" id="741276.A0A2S5B8G0"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000085">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="402"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY73047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="638" mass="71205" checksum="7B1888AE2ACDEDFA" modified="2018-07-18" version="1">MEMRKLHLGTLSYGVDAMDEVAHQLAVAMGDEKNAPASNLATGIALASRGRRDMSSRVKDVILALGLCHNVTPVVDEADGSVTYQASSPDEVAIVRFTESVGLTLIARDRTSMSVRTTSGVVLSYDVLEIFPFTSESKRMGIVVRDRQTGEITFYQKGADVVMARIVAYNDWLEEECGNMAREGLRTLVMARRRLTEDAWKAFEEAYRDARVSLGDRNAAAARVISEHLEQELELLGVTGVEDKLQEDVKMTIELLRNAGIKIWMLTGDKIETATCIAISTKLVSRGQYIHQIAKLKSPEQARDELEFLQTKLDCCLVIDGESLQLCIEHFRQDFIELSTQLSAVVACRCSPTQKADVARLIRAHTKKRVCCIGDGGNDVSMIQAADVGVGIVGKEGRQASLAADFSINQFSYLTKLLVWHGRNSYKRSAKLAQFVIHRGLIISVIQAVFSSVFYFSPIAIYQGWLMVGYATLYTMAPVFSLVLDRDVNEDVALLYPELYKELTKGRNLSYKTFFTWLMISLYQGGAIMLSSLILFENEFLNIVSISFSALVLNELIMVAVEITTWHMLMVVSEVITLALYVVSILFLPEYFDLAFVLTPQFVWKVSLIVAISAAPLWVIKYLKGKFAPTQYAKLRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8G1</accession>
    <name>A0A2S5B8G1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8G1"/>
    <dbReference type="STRING" id="741276.A0A2S5B8G1"/>
    <dbReference type="OrthoDB" id="360923at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="140" mass="15083" checksum="1F07A172F04C9ADA" modified="2018-07-18" version="1">MLFRSWDAFTQACVALCDSADTQTRTCIRWRHQVGLLVIKVTDDKQTLTFKTRSSVYLNRFDSLNRQLLRRYANKQRATATSLPLISEQQATATATAGGMQADEPEVADAASAAAGDSGAAAGGAASKKKKSKGKKKANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Q1</accession>
    <name>A0A2S5B8Q1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_3784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Q1"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Q1"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="325" mass="36425" checksum="34C8EC658B9DC5ED" modified="2018-07-18" version="1">MADSAGWSLTESDPGVFTGILHELGVRGVQVEELWGLDSDLLKDLEPVYALIFLFKWVGNADPATMDGNLQDPPQDHYFAHQVINNACASIALLNAALNIRDPNVTLGDELTNLQAFSEGLDPETRGWTLSNSEKLREVHNSFARSDPFHLEDHQRPDDPSEDAYHFIAYLPIGDEVYELDGLKPKPVCHGKWDANASAGGWTDLARSVLERRIATYPAGEVMFNLMALTGRKSRLEAQLEALPVESSGERFELEETLRGIEERMKDWETENALRRHNYIGLIHAMLVELAKQDRLGAQIEAAKSKMKERVAERKAKGEVMMEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8U2</accession>
    <name>A0A2S5B8U2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8U2"/>
    <dbReference type="STRING" id="741276.A0A2S5B8U2"/>
    <dbReference type="OrthoDB" id="3235570at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="5"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="158" mass="17080" checksum="541C6B803C09A531" modified="2018-07-18" version="1" fragment="single">MASIVVMEGFMLKKKRKALQGYGRRYFRLSSDGQLSYAFNPHAPVRDSVSVPLAFISASRKHRTLDIDGGNAVFHCKCLSLADFDQWATASKAFINVAHRNKDSAKIVGNRLLSSPTTTAAAAGIPAAGNALDRVYAALAKLSQPICDLELVAHEFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8U7</accession>
    <name>A0A2S5B8U7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8U7"/>
    <dbReference type="STRING" id="741276.A0A2S5B8U7"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF7">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="391"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="67662" checksum="E12534D263CC8D97" modified="2018-07-18" version="1">MPKLAHQTGQRGPAKPYGRRDDATASSRPRPTRPRPDGPGQSGQQQQQQQRHQRAGPRAPPKAAAKPSKPQQLDLSGQQLTAPPSFADFTALSKLNLTNCGLTSISFVKQVAGSLTWLNVSGNDLSGPGAWDGVETLSTLFVLNASHCSLTETPRCIASLKSLKALVLSHNSLTKLEHVAKLPDLNTLVVSNNSLPALPKSLATLPALKKISAAHNQLSSAGLPDLSALPHLHELRLNDNRPLSSLPSHFGSWGKAALPPSETSSHDPTKPRKGGLEILDIGNCGFESWFGLRELVKQDGIANFGLKGNKVAEEAIAANGADGFREKLQILLPSLRILDTHRFDAKHAELKAARSSRTAEQKILDAGPMALALNAKSDAPVEVTELLKARERERENKRRRKKGIAEEVGEGKKRRRDDNEVDDAAMAHSDNAAGSAVEKGKKRVRTDQEGDVDAVTDPEASAAAGAADKPKKPKKRTKAERKALAKARDAEVTTVGPSAAPDADLAVPRKGGALDALKDDGSAAPRPVSAPAAAPPPPPAEARPEEKQKTSVAKIVEVRKPDGGKKKGKKSKAAADSERAAVDVGALLGLAPDPTESASLGDSTATIDGPATAATAKEDPLASLGSGSGNAWGAAGNGLFGGGGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B975</accession>
    <name>A0A2S5B975_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B975"/>
    <dbReference type="STRING" id="741276.A0A2S5B975"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="171"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="815"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="904"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="854"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="950"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="974"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="329"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1060" mass="114204" checksum="D0A301624E32327F" modified="2018-07-18" version="1">MSTRPSRVTRSSAAATSAVPAAPATRSRPGSSLSQTAQSTLAAGPQATRRTTRSSRANTPVPPSDAVDAPKTRGTAARTAAATRPQWGAPVRTPAVSTPPQSAVRRPAGSSLAVPTTVQRTRTPGQSLLSRMTSRDSLRQQATKTPARASAPTPAPAHANGLETYDGRREPIKAYLRIRPAPDGVPLQSYIQILNNTDVLMVPPADHRLNPSSSSATLFSNALLRSSNLALNPASHPSGVPDDVLASPTPHVPDPSTYGTLYKFTSVFPSPASPSATPIVSPTSPTFTPADREKAQRSPSQAEFFRSTTLPLVRDFLQNGENCLLFAYGSTGSGKTFTVQGGKGEDAGLLPRVVEVVWKSLEAKRQRAVTPPGSRRPGGPLMSTPNGKGPQPAEDGSTEDATSEVVAMDAGFDYSVLVSYSEVYNEKIYDLLEAPLLAPPPSTPAPASHAGGGGGGMFKGLFKNFTTVKRSALSLKADKGAPAAGPGQAAAKVVGGLREIKVSSAEEAHGVLARGQSNRRVFSTLANRASSRSHSIFTLKLVRTCRTTGVESTSRFSIVDLAGSERVVNTQTTGDRLKEAGNINKSLMVLGQCMEVLRKNQEKEKGRKPAIVPFRHSKLTEMFQSFFVGDGKAVMVVNVNPYETGFDENSHVMKFSAVAKGVMTVKREPEAYHTALAPGPSLPIDFEIPEIKKAKPEPRLVRISLVDDGEEQEVLYEEEDVDDEDADEDEFVNALLDELSALRTALFESRMQVELAQSSVRAQVVKEYEEKMLEMERRYQARLREEATGRAQADEAEMKLNAKLDILTRLQAAKTPGRGATYRSREQTVTPSTQYDDSDEEGIETEREGAGESFVDEDEAVEGETNDSEEVQRMLMPETDDAESPLAARVKLLSVDRPIQAKTETLPVRSPLSRETVRDHSGEDLEPTQKAADREDAVESDEGSETVSDASREDSFGPRDEARAEVDEYSVPLKMEDDRSTRTTGAADKENESPLGHGDRTLGEIDALGMDKSMVIRSSGGGAKKTKRKLGVKVVDVEDIDTYEGVLSPIRKTPSDSRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9G0</accession>
    <name>A0A2S5B9G0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9G0"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="61120" checksum="671E42B6EADF4813" modified="2018-07-18" version="1">MSVLLHIQEESPTSSAQVPLLGHSGDRSSLPRRKRPAYFVRIALFSSVVIIVALAFLQPDQRSKAYSRLSALQKSTAASSSLAAAAPPYAQSCELCHVDPTNALCQYGEHNIRLSRAFEGSGYRLQRFLRKMVAGEEVQVGVLGASITQGHSVLPGEQTWQEAWFADLQKDYPNVKMHVGAVGATDSQFFSYCFSALLPVKDIDLFLVELDINNDPGLKTLKDDDALMRGLLQLPQEPAVVRISFFATIFPEQGRGTLSTLTTSQFFDIPVISIRNFLLPQVIKYRDSAEVIFGLDQWGNRDYRHVSALSHRAMADMLTLFFKKETCEAKRKELLRSVRKAPMTGPWWKEDDLGSVPEITLYESWMKPLPPRLVSPLCHSTVIPRSPLIPASHSDAFQLSEWNGKSAWISSEPGSQIRLRFTGSKVGVFVYSMAGPVTGHAAGKKVQSDKEKEEAAKEAPGMAYCWVEEPGQYERELKEEKGRSSPKDRVKAKERVEYAVNTHEPSKPASGTAFVELADGLPAGKDHILACEVSNQTTSGGHKWRLQAIASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9T9</accession>
    <name>A0A2S5B9T9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">chitin deacetylase</fullName>
            <ecNumber evidence="9">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_3483</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9T9"/>
    <dbReference type="STRING" id="741276.A0A2S5B9T9"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF135">
        <property type="entry name" value="CHITIN DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015559075" description="chitin deacetylase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="14">
        <location>
            <begin position="78"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY73545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="393" mass="41106" checksum="8594C44719E4ACD8" modified="2018-07-18" version="1">MYQTVLATAFLASTAAAHQLYSRQSAGYPAPLTKGPQPKQEWVDTYNRIKAEGKIPGFAPSTPNGAGGVTYPAGTDQGEDGVCSWTTAHCFGDNDIYDAPDNMYAVAFDDGPVPQSERLYQFLQQNNQSATHFLIGTNIVQYPASFKAMTTLTDMQVLGELGWTAQALFDSSGGIVPKFWRPPYGDADNRVRAIAEEVFGLTLVGWNRDSNDWCLNYGLGNCPSYAPNSQADLEGELNGWINGDKSPGPMGLEHDIGDIPISAFINTYPGLKQQGWDARCVPDLFGLPWYQNAARNGTPVATTLGIGMGNVSVPMSSSAAASSMSASSASSASSSASAPVTTSSSGSSSAPSPSATRSPAEAAADKSGGAVSFSISALASALVGFAAITLLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAI4</accession>
    <name>A0A2S5BAI4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAI4"/>
    <dbReference type="STRING" id="741276.A0A2S5BAI4"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="329"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="713" mass="75928" checksum="9B8D8EA19EAE7E53" modified="2018-07-18" version="1">MATSQQARPGDTLSFPTDHSRLNALFESYKLAAPSLGELAVTSSTLSTPFHLAQLGQHSRLSYQQVADRAKHNQLKAGPDGELLYVDGEGQVVAVQVDPETAALRTHALLQLPLPSSSNPAAEYPDALPVAPLVWLVNDGQGSLYLMRVEKDAERWTARLGAASRLNGENGEPVPLRLLAVEALEGTDDAVVLFSTASKTAAEPDLPKEVAPEPQAAGLAASSRLAHRSKTTFDFHLARITLTNPPGGEPTRLEPLWKAKSDELPAFVHYDAVLKRFAIGSGARVLLERGGAAIGDDTIPIDENSEASSGQQGDTDMTAASSAPVARVPKPPPFSWTQDGDSVTVAFPIPSDTPTSNIRLTLSRQFVTLHIASAAAALAAAGSDVANAALPRLSHKKLWDSIDPHTSVWTFDREAEGRNSTYGILTLHLEKANPGTRWSDVFESKPKQDDSQQSVSRIEEIDPEEEYEHVAETLDPSELAAISESMEQWSQSILQGGGGPSPLSHSAEGLGSGIPTSLTGDEIDVEVDGDSGKAFVVTWIEDALSSTPRSICPHPTVPHSLLSTPFPSAENLARASTIAVQHDVDGLLYRAPSSATDFRWTHESTFPALAFVLATKRDTRFVYHLGDRACFAFDAPALLPGPARSRPTIGAGNAFVYVAPDSPRAKQGTQHVVKVGSPDSGALVGVVSTMLASGEPVIVALCERELVTLRLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAY4</accession>
    <name>A0A2S5BAY4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_2981</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000031">
        <property type="protein sequence ID" value="POY73939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAY4"/>
    <dbReference type="STRING" id="741276.A0A2S5BAY4"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000156">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="65"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="269"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY73939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="526" mass="58318" checksum="DAC3108AD630B137" modified="2018-07-18" version="1">MATTARRTSNATEVRHTSRRSSRIARGSVSEVGRRSEAGRLQFTRREDESGTPSANKKDMADYLVKFEKQFTLTPQRMRMIVDSFIEVLERGLEKKGEEVPMLPTYVFGWPTGQEKGSYLAVDLGGTNLRVCHVELEGDGRFEVTQTKFRLTEEQKHADAQGLFDFCAECLDNFVKDNFGDDDGKVELDEPLPMGFTFSYPCEQDRIDHGVLIRWTKGFGAPGAEGEDCAAMFKKSLQKYNTPVEMVALINDTTGTLIASSYVDQATKAGIIFGTGCNAAYMEKVANIPKIKHLNLPEDAEMAINCEWGAFDSTTHEHLPRTSYDIHIDETSNKPGEQAFEKMIAGLYLGEIFRLIMCELIDEGVLFLGQETYKVEKPFVFDTAFLSLIESDPTDELLTVTGLFAHFFSLDTTIAERQFMRRLAILIGTRAARLSACGIAAIVSKQALLDDITDVKKQTVGIATDGSLYNKYPKFPQRLEEGLVDIFGEKGRAIKTYHAEDGSGVGAAVIAAMTKARKAAGYATHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAZ1</accession>
    <name>A0A2S5BAZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000032">
        <property type="protein sequence ID" value="POY73928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAZ1"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="500" mass="53201" checksum="E6A782BD3924498F" modified="2018-07-18" version="1">MAQHSPPRPLTANQQRAMAIEANPAFWRTVPVQGIVDRLIEAVQIQDVLLVVHGLQQLKKAFRSSADVFRFGLARRHTTQPVTAISAVVDVPESDTRAFVFRLLLIHAGDPAVGTALREALGNQDSWAKTALDQLAGADAKTRQEMLGTPLFLLSIDLRSVAVFVDKNFATSSAPLAVCATGEEAVPKSAPAKRSPLAVNEAAGGQSKRQCLEKAQEIGRKLVQGASGSGNKRDATLADDLFTFVHDGIGSAPAGFCLSADQKQARFTLRLEDDYLRLLKTVHVTRFKSLTLFVDRDPPARCQPSHPRVELEPWPLLLGHAELFNTIKSLHIGAYCPSIEPASALPSPNMAGQISTTSACKKHGKASFRVPSVAAAELAVRELANARIDQVGAITATWSLVSDNKRSIPRFAFNLGASSNKAPAALPPGTSEQSWPAAWRHEPIGATSSGQSSELRTPPTSPLAACSTEHGAEPVGTSSLRVDATDADPAGATARVEKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB32</accession>
    <name>A0A2S5BB32_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY73986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BB32"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="1778"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="416"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="675"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1385"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1462"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1537"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1663"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1703"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1060"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1164"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1469"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1547"/>
            <end position="1569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2113" mass="230499" checksum="30C43316AC0505EC" modified="2018-07-18" version="1">MQDSATAQDRAAKAARAKDKLRKFQAQKRATAAANGTPTSPSSPPLSPVATTAVRPVSPAIEPPPSIARILEASKRAERSTAPSPPSAASTTPALDPAPPVAPAADSARGAAQSLGTAPTPRRPSPPPTLFDESVPAARRAFSPPLPAAAAAVDSTTTPNYSPLIRSIASPPPPRAAPPARSDTVSPTASVTSGTTTTSSSFFSLSKNAAHLFGGLAATARDGAVAAARRGLQQQQQQNPYYSPRGRGYEDESPARTSLDSRTDRHRVGSFDFEDDGAPESRLRSDADFPMSTTTTSESRPSRADDRSAFFSPSPPEVAQLAAERDSLQAHIRDLEAQLSESVDPRQVEGLRELVDRLEEEVSGFKAREEENDARRHDLERGVGLAREALQDANGQLAAKDVDLERLAAELAVARSATETAATEAAADRDRLNERAQRAEEEAARTAQELARLREERGDAVVESQREREAAVEQDRIEFEERLVRFERDARDERERERAARTEVERERDTVRTELEAERERVHALEAAVAAAETSAPEPSHTTKVNELEAELDELRQTLARRGEVLASTRQDRTDAEQVSLERQERIDALGGDLAALGDEPARCRSDLEKASTERESIREELNRYVSSHGAIVERLRDQVDQATREADELRDRAGDLGALQAQLDEAITARADAEKRLSERDGRMSDLEAELASTKDQLSTHTTRADHLQVQLAAAGSAQEELQKQLSTAQQQLSTVQQQLASAEQARDTASADETVSRADLQKSLDEALERGSSLQTKLKASEEQSAIRDENLATARRELALLQEQYATLEKASREARSVDEEMVESLRKELSNVQQEAEGLRQQVRESTDRIAKLEEDAAAVRDEADKLRQNLASLGDEAAAVHSQADELRRKLETAEANAASAETAVEQLRAETAAQQQRLERVQAELTAEQTRAVTADDALKLAQKDLDEARTQLDTLQEAKQSTLDELEKLRAEHNATPPSAPQDVERIAELEARVQRLEQATTSAGTETERLRSVEADLRKRVESGPATGTSIASSIAGLSRSSTPTLTNGNKLTELERDLQVFKDVLAASESRATGLQHSLDAAEKDLDDRESEILRLESLLEDAAAKERELETDMAALAAKVAEHASRNTELQSQVDRSKSFAAAPLEPNGHKAEVEKLEAALATAEGDLAGAQQARQAAEDDLRAQLDQLRTELKSRTVEAEAAAARSTGLATELEAARAEIARLETAHIEAQRQHDDLAITHSSLRSELDAFTSSDTSTAEEIAALKASLATAADSEASAQQQLASLHNELSRLETAKREVDEELAQCRGEVEETSATLSAAMAELDSTKDEVVELEKSVEDLRIKLRRAQEGRLASEQEIKAIEERLADAVRSKEVAESEPVTLRQGAESASPAGLGPPELDERERAELEALRQELEVERARFAEASRALVDVREMHSKARQEVERLHAIATGPANEASPSTNGKSDQSADEASDALRLQISEAQAKIRQLEQDVFTLESTRLKMLKANGDLKSQVESMMDALAQERTRARMQQADAESSTQYDHPSASTANRSQPSPGSARVPQGDFPAPPLTPSRRGHVHRRTASTLAPVSEVSDSSHETATGYQVEAGLDEAGEELAGVDPLTPLGSPPIVTAINTPAASVAPTPMLPRSSTMGDRLPDAAATPASRKDHVRRASLSLLKARMEEEFGVPDLDKAGPLSPVGRGPSPGGASDGPRTHRVPLSRDLVCARFRMALFVDRYRPRSLDDLDYHPELSSRLRALAAGDFPHTLFYGPSGAGKKTRIMATLRELFGPGVEKLRIEQRTFLTPSKRKLDVNIVQSNYHIEITPSDLGNYDRAVVQEVLKDIAQTQQVDLNARKRFKVVIINEADGMSRDAQSALRRTMEKFTSSLRVILCANSTSKIIGPIRSRCLLLRVGAPTEEQINGVVQKVAAAENIAIPDHVSLLLSRISLGNLRRAILSFEALYAQDPAFKSVKPDHSLLTTGKQDARDIDAVPRPDWEKYAAKTAEKIMSDQKPETLLEVRGMFYELLVHCIPAQLILATVTRRLLERVDEDLKADVAYWAAFYDHRLKQGNKHIFHLEAYAAKIMLIQKQHSLGFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB44</accession>
    <name>A0A2S5BB44_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY73996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB44"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29488" checksum="DE4143A468A16EBB" modified="2018-07-18" version="1">MGKQGLQTHPDRRQKKKPFQVGPKLAKGSYTGHIDRAKRTLIHKASVKKAYAKALKEAGYDDAPQSRGGGGGYKGKGRAVDHDEEDDDGEPVIDEAAQEAERERIRRRLYGNDDASDDNDQSDMDGDGSSDDEEDRRGKAAQVRPRRGASESASPSPSPSPEPETAPRPGGRSALPSAASAYATSKTLQQQQQPRRPAQKEKRGRAPKPVPTPKAAPKRPKLSEKELEEVRNRRRQEKRQGGQRTARGQAKLSSRLDSLLGKIKRSMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBL4</accession>
    <name>A0A2S5BBL4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBL4"/>
    <dbReference type="STRING" id="741276.A0A2S5BBL4"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="102" mass="11750" checksum="24C5C5DC3A2CE93B" modified="2018-07-18" version="1">MAAQENPWVTLVSQDGHRFIFPRQAALGSEMIKTTLSSDFSETTSGRIELPEQRAEIVEKVAEYLVYKDRYKETKGEIPDFKDRIKPEIALEMLMASDYMEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBM9</accession>
    <name>A0A2S5BBM9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenazine biosynthesis PhzC/PhzF protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBM9"/>
    <dbReference type="STRING" id="741276.A0A2S5BBM9"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37128" checksum="3374DD287ACEF540" modified="2018-07-18" version="1">MAPRELAYTTVDAFTSSPFGGNPAAVIVWPDATLAADDALAQQIAAEFNLSETAFCQLLDGGTALEPVYELRWRTPMTEVRLLSGRERAICESFQTDEKLICTGSAVALTVSGHATLATAHTLFTSHHPEAKTITFQTRHSGTLTARRVTDDGSNEKSDLIALDFPAAPLITLEDGHRRRPKIMEAVSRAVKAFDTSKVVRVGWWDGQKAPIVEFEAGTELESLEIDPTPFADIGELIILTCPAPAESGFDIFSRVFAPAFGVPEDPVTGAAHTALAPFWLLNDQSLSRLHDSKRAQTTSSLRAKQVSRRGGEMVVKLDEKTRRVDLKGSARRVMRGVIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBP5</accession>
    <name>A0A2S5BBP5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBP5"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="204" mass="21708" checksum="464CD1E8DC5E11AB" modified="2018-07-18" version="1">MSEPAWKRWLGRTFTVPNTGSAARDHLAGERTVLAWLRTSMVLTTIGITLAQLLLLPSSAFGSQAAQVSSISNSRVMSTSQGLDASQLLVSLQAESDPAVRALVQLVAAQQAQLDALSAAHPAILASTDTEPSRYAYLSRPLGGTFLALSFVYLLLGAQRYYSVQLALLREPSQFPPSKRSVAFVGMSIGALVIACFVAVLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC21</accession>
    <name>A0A2S5BC21_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="621"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1340" mass="139891" checksum="C01767ACA25851F4" modified="2018-07-18" version="1">MSDTLGNSGLSSSATRRVGSTDGAPVATTRQDDDRRREGDGDDDDGSDSDSLGALRNPRPMLARGAACDICRARKVKCDASRPYCAPCLKSSRGDTEAAADRCKYEGVTVAAAREMVVAARGGTTTGHAKGRKRKSEMAAAAAAAAAAMNDPGSDGGAVTKLGAKERKPTKKAAKRNSSSTGGEPESKRSRANATPASGSGRSTSLSSTSPPPPPPSHNTSHHTGYTHFGAAPPDFIANRGVRVAPLTSGGGVFAAGPSSSAGPPPSGMSGPTSTFEPSRYGSPFAGQHMAGSMRGDDPRLLPPPPPEASSLFRGTTSTNSTGHSQWALGVAADQVESDSLGRHQPQHQQYRPLPQHPYQQQQQQQQHHHFRSASSNAGQGYVSARDEGGGSGAQSSGAGAGPYHVTHLGAAATSDATRSSNGPVAGGGSMFAGPGTVGEAMAAMTGTSSGDRGDGVVGKEVVVGLEGRIADLERQLKQQETSAPSAGTDAAAAPGARSGYPATAPPPTSYTFPAPPSQAQSTQNGYQPPSYGNSYSTPFFAAQSPSSNAFFGAASPGSNTTAGGAQYGSGALTPGAYPPMQLVPPYGASPRTSSSAGSTFPPHDRRGLSALSAAAAANEYDQGGGAGGTAGYSMFAGSGLSRSNSPGTWAAASPSQLSSLRQSSTYPRRGSEPDAYALSSPRGAAVSAIRGQPSQNPTGAGQGGVGQQQQQTSTVASTPSNGEASASGTTQATTPPMPGSTSSSPNLKTDGRGAGSSGPGVASSQGNVSVVIGTSKTLPEPSAADAAAESASYLLDEFSLTPDLYQILHPQYPLSLPPLSTLHHLLTTFFLRATIPSTMLSRAKILQSLVYGPADARWPEEALVHAMCAYSASFVSPDSLAGASTTDDDAIHLNSSYLGGFDGGIAAAAAASHQGARRLAYWEVEGDKNPRDYHYRHAKRCILEATGGIGMPGYKSSKRTNLLQVLQATILTCYSAYQLAQFMDVWMFAGLCTRLSTPLGLNHLNAWDFTANRSGPLAEDWGSRIRRTQRRDMLGPANDLEEHWERGVTFWMAFGIDRFASAITDLSTSIDEKDITTHLPCLATSPMPELAIDCETGLIPSISISSPQFLEDSAVPVGSLGVYIRSVVVFGRVINFLQRVPRNPCELQTLPCSVLKASVKLQPEFVELDIALSRFKQTHSANFFDEDGNGIDMFSVCAYILPHVATILLHESFTDRFDRTPTSSLNRCLTSAKCIVNAMTILYHSSYDLGGIDPFIPWCWSVTGRCLVRDYATRRYWGAHEEALASQVMAESVLGFHLLCAEKKIPIAQSLADTLKGYLDNPETLLPIDILDYRKPGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC46</accession>
    <name>A0A2S5BC46_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC46"/>
    <dbReference type="STRING" id="741276.A0A2S5BC46"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="127"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="246" mass="25433" checksum="1ECCA48120B4844B" modified="2018-07-18" version="1">MSADGTSSGRRRSIDDPDSLIASTSPAAAAAPQQQSQLGAPAPSSDAAGGDDDDDADEAEIAAMRARVAEMEAEAQKLREMTAASEAAANGGAASGASGAGANGGGDGAGGEDVNMSDEDRAAVDARSIYVGNVDYGSTPEEIQQHFASCGTINRVTILFDKFTGPKGYAYVEFAEPSLVQNAVLLNESMFRGRQLKVTPKRTNVPGFNQRGRGRGRGGYRGGYQSRGGYSPYARGRGRGRGRGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCB8</accession>
    <name>A0A2S5BCB8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_2597</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCB8"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="160"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="1848"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="2095"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="2242"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1562"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1775"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="2149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY74403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2302" mass="251044" checksum="33061AE327E0449C" modified="2018-07-18" version="1">MDGERAPTSSKRPRSVDDGDSAKDREGGAVGSRLIQTQIPTPVATASPPLESAGGLRSYRIDVPAGEPTPKRARQEGPAEGKVVSPRSESGATTASNHRSYFPPFEGFEGASSPGRSGWSSNNSMTSRPLPSSPAKAPDRAEHRRRAEVALQQKYGPHASPALPSPGLSSFAGVFRRPKLASSTSRSGSSDTKVAPGDELRLEGYRDVRVLAVHYDDVVACRAISTARDDQRVLLKFSLLARPSVATHFKAEVLLLNKLRSAGISNISKPLAHEHNRYGSMIVALDEDLRFWSELYLRRRAVSPRWEDPGAVADMIDRAVGLVQLLNSVHALGLVHASIRPTTISTSPAGEVFLHDFSCAYTAEDYTGDGQTAPSRERGLKEESLPYLAPEASGRLGTAADYRSDYYSVGCALYEVFTGQTPFADAFDPLEILHAHIARQPLPMTDVESFVPLGLSHIVARLLEKNLEARYQTGQGLIVDLERMANLVRAASATPSALGQVGADFVPGVVDRKAHFSLPPTTKLFGREEHVRQLRASFDRVKETNRPAVVVVKGSSGVGKTSLIETLRPLAVTYQGHYTTSKFDQIKSPVPFFAVTHALSGLIRQLLAEPEIQLITWRRRLARAIAGEGRILADILPLVEQMFEATWLEQQPVLPTLSPQESEERTRALLRRVLRAFARAGKPLVVVFDDLQWSTPSDLVFIRSLTEAGDGGEGDALLCKMANPTLVLCVYRDNEVGPDHIVNTDLLPKVASIDRVIELPPLDLASIVEFVGTALHQPATASIRRLGELVLSRTAGSPLFVAQLLRAFHLDGSFLFDFTREEWSFDLGELAEKTISTDVVDLLVAQITRYPSATQSALQAAACLGNEEIEAERLATAIGVSVLDIARDLRAAVQDGLLLTSEEPVTGSEPVSRRPSAVPSSYRFYHDRVQQAAYATIPQEARARMHYTIGRRLASALSKDEVREHIFELVQQMNAGLSLLDTTAERDTLARYNYIAAKRATASTAFEPAHQYLLKAVDLLGAGAWLQQHELMSDVIELLVEIEYSLTDYAAAQSWIALFLQHVEDVAAKLRVFVYAIRSAAAVGDSTRAIELGTEGLALAGLRFPDSTEEADEIVSLAAVAPDGDEIAAGCQQILAALVPPVYFVRIDLLGGLSSLSLDLSLRHGLNDAGAFVLTLHAILVRSRFGEHAESLAYGRTAVAFFNNTKGSPLACPTYKVYSSHVAIWALPIEDVLVTFRQSIAYGMEYRDAEYLGFGTAECCAYSMLFGGNLDELSAELERYAVLVRQFRNELSSTYIGVIHQTVLCLVGRSLDPCAVEGDAFGGNDLQVCQERSYSLTILLAATFGLMLALLHNDPERIDAAIALGRPHLGGGEGLIFPTFFRMFQAVAFYQRSAILSRSDNNNNDDDDDDFLRRCHNELDGLAREQPRNFRPFQLWLNAARAASLDSPAHALAHFDIAIESASTCGIAWLRAYLNEQAGSLLANVKLGVGYLFEARQQWQAWGCAPKCTRLDTKYPTYFPSQPKAPPTTLFSTIPSLAADVRVPVWPSPLFSEPLVTAETDADADRRLSTPSHDASSRTHSLDVDLSSQSRSSRSDLANKSQLAVELDLRTIISASGVISSELSVEGVVSKLLRLALRVAGAEQCLLVLQKDGIFCAEAVARSDVDEVEHLRQDSSVDLYPDRYPCGIINLTARSQVGVLNKVDSDIANDPYLRQRKPKSVLSLALASQQRVVGVLYMENAHTSNAFTQDRLEILTLISGQAAAAIEKTRLLSDLKKSNDELLATQGAIESANRNLETKIAQRTAQLRQQNQLLEAEVSQREHAQAEMREAKEVAEAATAQKSQFLANMSHEIRTPFNAVVALSGLLLETSLTPVQADYVETIKNSAQELLVVLNDILDYSKIELDHLELSSEPVQLRPMLESCLDMVAERAATKSIELSLVIEEGDIAVTGDLARLRQITVNLASNAIKFTTAGEVVVSASSRPAEADEAGRPRRWCRVSVKDTGIGIAREHFGRLFRVFSQAEGAETSRNFGGTGLGLAISRKLARLMDGDLIVESEVGKGSTFTFEWLAVAARDESEDAYAPSANRDLAGKRVLVVDANETSRVVLRQLLTSFGLTPTVPAATEDALDLATKARTEGRPFDLVIVDAFLPAFGAQLLLRRLRQAEIELPKIALTRMGSPIHDDLRQQDCHFLIKPIKRSRLHHTIRSALPSVGQPSRPASPAPATPAFPALLATRNPLSILVAEDNPVNVKVITHLLKRMGYSCEVAEDGVVATEKAAKKRYDLILRAALAFSPVDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCH4</accession>
    <name>A0A2S5BCH4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mannosylglycerate hydrolase MGH1-like glycoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCH4"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="2">
        <location>
            <begin position="789"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1306" mass="146756" checksum="6803CA2BA9454DE3" modified="2018-07-18" version="1">MAPPSGPPGNAGGGKPLVKKPSISVRRMAAAQGASSSSAPAANAAPGGAKTSSSSSASTPPPAPLSLDIPAAAAISTADGSVQVPLKQSIEPREAGQPSLNATASPLPVTSAGVTPPLTTSGASRNSSNASSPAATSTGKPGASTKPSKQARNEANEDRGYEGEIETRGTGGDADDSDDTMTGRPTGRRPTLNKRGDSGVVHGVDHAEQGRNGLAQQQPGQSQGRQQQLDEQEHPLSEHLSRKNRNPSQASHAHPTLPVRPGRHAPSAKGRSPSVSSARSVEATSHPFPTPGIKQNNGFQFDKWKSVEEQRLDEDERREKHWKRWGPYLSERQWATVREDYSGNGDAWTHFPHDHARSRAYRWGEDGIAGMSDNHARLCFSLALWNGVDPILKERLFGTTGHQGNHGEDVKELYWYLDSTPTHSYMKMLYKYPQRPYPYEQLVRESTNRSREVPEYEITDTDAFDDNRYWDVFVEYAKDEDNAEGVSIRVTAYNRGPEPATLHIVPQLFFRNTWAWDKERPKGKDMPSMQQIGDGVVQTDHPSLGRYYFYANSSPAPVGPRRRDDKRETVFVEDTVTPDLLFTDNDTNLSRLYNVENKVPFTKDAFHDHIIPSHRPPMPKEKSSADAEEDSEEAGDGAETPRAEDTRHFVNPEKRGTKMGAHYVFNDVPGNGGVAVVRLKLTDRTAEEDQSILDEESFDMVMEERRMDSDEFYSRFNSGALSDDLRNVMRQALSGMLWTKQFYMFIQKEWIEGDPGQPPPPPERKFIRNRDWKHMHVEDILSMPDKWEYPFFAIWDSAFHCIPLAMIDPAYAKKQLDIMTREWYMKPDGALPAYEWNFGDVNPPVHAWATFRVFKIERKMHGREDLAFLERVFQKLMLNFTWWVNRKDSAGENVFEGGFLGLDNISPFNRSERLPAGGTMRQADGTGWMGFYSLTMLNIALELAKHNPVYEDIASKFFEHFLYIADAMTFHNGEVGEVSLWNDEEGFYFDAISWGPETLQQLPIRSLVGLIPLYATLTLEPSTFKKFPGFKKRMEWFIENRPSIWKRNIANMSVGGKGDRRLLALASEDRLRRILQRMLDENEFLSDYGIRSLSLWHKENPWSTNINGEEFSVHYWPGDSLSGMFGGNSNWRGPIWLATTFLLIESLQRFYQYYGNSLKVECPTGSGDYMHLAQVADEIQHRVINLFARDNEGNRACNGGSELLNKDPHFRDYVPFHEFFHADSGKGLGASHQTGWTGLVAYFIWNAGSTARLPRTPRTPRSVAAHYFDEVATPGASEAEMSAWESRSASEYEQDASDNEVGPEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCM8</accession>
    <name>A0A2S5BCM8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCM8"/>
    <dbReference type="STRING" id="741276.A0A2S5BCM8"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="89"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="892"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1072" mass="117458" checksum="357CA43C5734E7D7" modified="2018-07-18" version="1">MLRRFESSARRCVISARPSPASRQAVRAVTPAGARTIHALRSVAANNQTAQANAQTPQTGSRALATGLSQASTPVPASSVFAPLDTFTRRHVGPQEESVQKMLAFLGYESLDAFIDDCVPPEIRLEADALADHGPNGIRALSESELLRRAKEIGKKNQVTRSFIGMGYHQAVLPQVILRNMLENHGWFSQYSPYQAEISQGRLESLINFQTITTSLTGLDIANASLLDEGTAAAEAMIMAFGQLREKRKTIFIDRSVLPQTVAVVKTRAEPFGIKVVVGNVRKLISEDMGDAKQHKDLIGVILQYPDIRGEVADWEAVAKRTHDLGGYVMCATDFLALTLLKPPGEWGADIAFGNAARFGVPLGYGGPHAAFFACSDALKRRMPGRLIGLSKDAEGRPAYRLALQTREQHIRREKATSNICTAQALLANISAMYAVYHGPEGLRKIAEKVHGLARVTAEALSRLGHKVVNETYFDNLTIRLSGTAASVLHENAVQKDINLRRVDENHVAITFDESHSLEDVVDLLNVFVSIQTSRNKLRQVEPYTSESLIQFAESIGVQGPGADTVLPAELPPVESPVIPKHLARTSPYMTQSVFRSHHTETDILRYMHHLQDKDLSLVHAPICTMKLNSTTSMTPFTWDEYARIHPFVPAYQAQGYKELTDELAKDLSTMTGLPGCSLQPNSGAQGEYAGLSVIRAYHRSRGDTHRNVCLIPQSAHGTNPASAFMAGMRVVVVKNQPNGYLDLADLQQKAEQHKDNLAAFMITYPSTYGVFESGVERACDIVHENGGQVYLDGANFNAQVGLTSPGRVGADVCHLNLHKSHSIPHGGGGPGMGPICVAEHLIPFLPGHPVVATGGDNAIGPISAAPYGSASILSISWAYIKMLGASGLKHATKLALLNANYAMDRLKDHYRVKFVNDKNRCAHEFIIDLAEFDEKAGLKVMDVAKRLQDFGIHPPTCSWPISTAMLIEPTESEGLRDIDRFCDAMIKIREEIEEIVSGKQPRDNNVIVNAPHTQQVLLSEKWDRPYSREQAAYPVPSLRSRKFWPTVSRVDDKYGDMNLICECGDVSEYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDB9</accession>
    <name>A0A2S5BDB9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDB9"/>
    <dbReference type="STRING" id="741276.A0A2S5BDB9"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="359"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="546" mass="58565" checksum="6108B43507EC3F71" modified="2018-07-18" version="1">MASGSSATASMTVDELVQRIQRAQPAEFDKHILPTLRKLDKEAAVSSRGQRGAGGRSAGPGPPTQANAAAAAGQAASTRTAQGGATGSNTAGPSQVTPSGHLLEQRLKDGSDPLTALDPTLHAIAYLFFLNARLRAYAPDWNGLRPYVQAWCDRCDIDAVRDCPEQVLAFANLLHRLGDATNQPALPLQPLNSLLARYPLPGYLTALHPLFLRVVMDSQLYPAAIEVLQRDITDVDKHLFPVRYQDHLLYHYLGGTILALMGDYSRAADLLETCVSAPGSHASMMQVDAHKKLLLVQLLAHGKTLPLPRYVSQAVVTATKTLSAPYSEFATAYRSLSKARVSEALDKGRDAFSRDLNWGLATLCAESLRRRQIMSLTETFVTLTLGQVCSHVGMPEASDANLKEVEEEIVEMIARRQIYATLTPPEPATSRAATIVTFSDDPEPYLSHETVSRVTTAIKNAQELEKRWHGEANRLEASKEFVQKAWSTAAAGPAGALGGAGGAGYSGFSNVPGYSDDFDYGSYSPAAGLGGTSWVDAGDDAEMGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDI3</accession>
    <name>A0A2S5BDI3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDI3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDI3"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="332" mass="36380" checksum="04241F4AF9B94BCA" modified="2018-07-18" version="1">MAASIPPRLIARRTDIGCNLADPVFRGSYHGKQAHEDDLDEILKRARNAGVTAQLLTGDCLEGSKEVLALAEQHDGLYTTIGCHPCRASEMDAYAGGPEAYIAALDQLIVENKGKKAVAIGECGLDYDRLFLAPKESQLRNFPPQLELASKHDLPLFLHSRNCHSDFVSLLKAHGKPLQGVVHSHSGTAEEALELISLGFYIGINGCSLKTQENVDGVKRLPLDRVMVESDAPWCQIRPSHASYPILDEFLKRPEYSHLRENFMPLEVKKEKWVRGKAVKGRNEPCATSQVACVLAALHGVSLDEVAAQTRQNTLALFGPAGMKEEEQSPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDL1</accession>
    <name>A0A2S5BDL1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDL1"/>
    <dbReference type="STRING" id="741276.A0A2S5BDL1"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF40">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="194"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="382" mass="41900" checksum="C56DA5838E49D982" modified="2018-07-18" version="1">MDTPPSPSLSATSSSRPSSLRSAHPPPPKRLVPARKPVDHSLPPEKESWGQWWKRKGNSWGTTAAVKGIAISDTVGGRVNGIATGYLGVERFWPTSNDGPEEMAKAARILRAFTEEGVGATVEKKDEKTGAKIHHKIMRKIPKSVIRQAKGLIIFSSMRNGIMPFGGAGGSGVIVARLEDGSWSAPSMISPNNLTVGLLGGVDFFQCVLILNTQEAVDSFASHKITIGTEIAVVAGPYGQGASAEMGKDRQPVYSYTRSKGFYAGVELVGQAFLCRWDENERLYFWPGVTQKDILSGRTRTPREAEVLLEAIEAAESGEAQKAHGAENEFEELMPWEDGSVIDLNEGETLRLPPTPDQLSREEEEEEWKRLKEERDSKRFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDX0</accession>
    <name>A0A2S5BDX0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDX0"/>
    <dbReference type="STRING" id="741276.A0A2S5BDX0"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="459"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="851" mass="93282" checksum="CD23F0D62F285688" modified="2018-07-18" version="1">MGGPQRLERALGDSAYNHFEERSVRSATTVATARFPRTATTRFEPGASSKLASYDWDALSQAAQPPAAEPFPLSTSLDRAHVLAQHALLVEREEQLDRANQLRTGRLVIGPGKRCSQCGLAGVRALERGFLAGDVHLNLPTERRSSISPVSQVVQGSKLLPIRIVTQPLRTTSIHFVVEDSAGNAVPVQLFGVPTRIDAQELAEWFPPGAVFGIKEPLFRRTSNGASYYIRIESPSDFVRLYPRDPLLASVHFPPSSAALRHWLDAFNPVQLKAAGDKAFAAKRFVKAKEAYELALDALEPTFGPDSDPTTLDLRTRLYANLAQAFIKLEMWHGAFCAAQGGSQAFSMRPAALAGTFLIEAQSLLLMKIRYRAALADYHRGRYDSAKTTLLQILRAGFAPSDPDPPLLLARVEARLAEIEGGPSVDTIRSLWSDSLDMQERNQRVPASPPDLADWIDYAALSIVPIPGKGNGLVAKRRIRRGELLMCCKPLACAGGFQIGQLRYNAGVNLWTRSEDPWAVGEVVSEVLWKAAQESGPSGFSAWAAEQVDPLWAGEDIRLEEQLGPITSGIHPSKVEGAVTYNGFHVEEVSASTLDDSAKRDRSDPDDLFHAPTALYPRYPSALNHSCLSNCTYTFLHSVFFLRARIDIAEGDELVDSYVDASDPLEVRNAKLAAHGFQCACELCAEEREVGEPVRERRAQLVKQAETLASPDVDELRRIVEELETTYGQTTTIRPALYTPLRLLSQALSTRAGSSADAIANEVEALRCLGASFASSGGEERLVTPSRLRDIDAVLSALWIAKEWKRAGRNEASRNWIALAREIEVGQAGAELFELRYGAWARKNGVDLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDX4</accession>
    <name>A0A2S5BDX4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDX4"/>
    <dbReference type="OrthoDB" id="2525151at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111259" checksum="249EEA44FC4AFA1B" modified="2018-07-18" version="1">MLAKAKLVACRCVSTSTAGPCRHGIATTVRRVATSSKSAAAAAVQRETCTEQAPVAALDYTAPLWATTAAAQQGRARWFGPARPAWADWNRTDLQPAPARDPPPPKVRTPPDAPLQVSSKVDEARPFALRDAAEAQLSTYLRSRGQRTALESFRDDYRDLLDAAERGDMPLLRAMVLEDQELAQVPHRGLKLLELDRFATNRSQKDGEGHMHRVVSARLPAPGEVVTRGRRKRRAALARTSSPAPAPEQVPPETVSPYDCLSSFLTVPVSDIAAAGEAWHSFDRATRADQSDRDLHLAIRFLFHLVQPGRPGSKVEELQPRLQLALQVLHRLLDVFPDEVVQPEPTRTDLFQEVRLQVVLLRTAIEVARREHMYETVESALGSIDQLREVHPVLATSPESAFDITAVESEVRRGLGALRDERQTSYAPSLRAEAWKMDAEVARVARVVRYRYRWSTSVADPDQPTLAPRLDQFLNTFAAECAHRQRWDLVAEMWRLWSARGWHMDGQALSLARWFAGEMPSSTYGPGPLAKTVLQPRLFVTLAREVHADVQRGSQRVTWTAGEKNDWVDLLCASRVASRSTREMARELVSIWQRKDPVGSALPFVLRGSTLLNLLRTALPPYGTDSTYARSGLSAHVATLVNPSSPYSSPNGRIEHYDLTTLAQAFTLAGDHVSVGQIYRRALEQKQLPDAKDVTVVLADAARRYPRGAFEQVAKAAASGLGVDLELIQAVLKAQLDQLRSRSSQASRPVADVPEEMREAVAQACRLAQELRLSEGQTEHLRRYGEAYISAGLDAASKPGRADGPSKLSVGRIIGDLLKASQTTDWRLAHRVFVRTLVRDEAGATVAHGVRDERVLTLCLGTLLKADRAKGYRAERPEIRDALRQVLDAAVAPISRLQPGETPLPAGNVSLVSTRAGLDLVLEALIRIGLPADVDALMAALDRQAESLCEPGLQPTDAVVEKAVRWAIAHRGRAAVLADDGWLAQRAQAIIRPEPTTETRMWGRKAVAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEC5</accession>
    <name>A0A2S5BEC5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1758</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEC5"/>
    <dbReference type="STRING" id="741276.A0A2S5BEC5"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF14">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="231"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="467" mass="49987" checksum="872A13A59E55A03B" modified="2018-07-18" version="1">MSTGVPRRVAYPHSDELLRVADCLPVNEGRASLVHALVDSYSLLTETAKEGYARVVEPLRATREQLVRFHDERFIGTSDAILGTEGAAGNSSDLDSEEESEDGARPPTPIFGLDRAPSSPHPRKRRKAEHGSSIGLQDDCPVFAELPDYVQLVAGASIQAARELRDGNADVAISWTGGRHHSKRAEAAGFCYVADAVLAIMELRSGPGPLRHSSPDLDTPPLPLPPPPARISRVLYLDLDLHHGDGVESAFFSTPHVLTLSMHLFAPLFFPASGALESTGPVGRGRAKPAAAGHALNVALEPGLGEETFMRVWESCIVKVASAYDADAIVLQLGVDGLAGDPCKEWNLSLSALGFALERVLSWNKRTLLLGGGGYDSPNAARAWTYLTSIAVGRPLALDAAIPADLPTAQYEQFAPSFSLDVPAGHVQDRNTDGSLARVEEAFERYARDLVAKKEAKSAKSTRSALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEF9</accession>
    <name>A0A2S5BEF9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_1790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEF9"/>
    <dbReference type="STRING" id="741276.A0A2S5BEF9"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY75158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="362" mass="39330" checksum="23B265F6073A54E7" modified="2018-07-18" version="1">MSTQREVRVAVAGATGTVGQRFICLLSAHPYFRLVSLNASPRSAGKAYKDVVRWKQSVPIPKNVLDMVVKTCDVDQFGDAEIVFSGLDSDVAGDVEEGLRKAEYAVFSNAGNFRRDPMVPLCVPLVNPSHFAIVPHQKEALGLKKGYIITNANCSTTGLAVPLYALERAFGPLETVMVTTMQAISGAGYPGVPSLDILDNIVPYIGKEEEKIEWELTKILGGLADDQKSFDLHAKHPMKVSASCNRVPVVDGHLECASVRFARRPPPSPQQVKDALRNFYSEAQKLGCPSAPEQAIFVHDEPDRPQPRLDRLFQNGSGVSVGRVRECPVLDLKFVVLVNNVNLGAATSSIINAEYAVAKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEI9</accession>
    <name>A0A2S5BEI9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEI9"/>
    <dbReference type="STRING" id="741276.A0A2S5BEI9"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="206" mass="21725" checksum="B758878B3B9568F4" modified="2018-07-18" version="1">MDEALGWGIAAGVCYFAYKLVFGSSPRRRQISQASVDQVTTMFPNVSQHAARWELERNGGSVERAVERALREGGLPEPPASYFPPSSDSPPAAAAFPTTPVRAAPTPQTPTSGASASGVRGAPPSLIARMGLQAQVAADAKGKGKATEDGSASAGGWSPKAEERERNLRARKEKLVLEARRKLLEKEARRKAEAGSSAEVDQASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEM2</accession>
    <name>A0A2S5BEM2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEM2"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="427" mass="46132" checksum="B4E84A215065527A" modified="2018-07-18" version="1">MADPLIGMSFSFVPAAPSRERDDAPRGGNGSQVLPVAELAEDFDGQPEDGSEYLFLVRREASLRSKITSVANPYETVQDTSTSAKKARTVPTSRPDDAWRESFVRNFTATRQRMLRAPLHALEPIDPASIPPPRDSSSWRILVNGKRAKVSRPREPPSTSARPNAPVSTARDVTDMDVDLSPDAELAAMKAAALASLGLDDSHSTTTPPAVPAILAPPNTATVSDERARMDAGPNDHPAEPEYERLPRLPSPGIIASIPGPSIIHVLAHFDEWLNERLEAHEAVVNYVPSTIFAPPSLRRKAGAKAKPAVAPTSVPAPPATTSRPSVGRAPLPSAHESHWMLSLLTRLEQVLDGDDLSTLRQLAKTLSKLIEASEKVTAGRTRPSSGRTMEARRVDEEEAEGRARCWMIVAAIASVWAQGDLWDPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BER4</accession>
    <name>A0A2S5BER4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BER4"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="8">
        <location>
            <begin position="482"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="557" mass="60376" checksum="3C162E70A45B2D12" modified="2018-07-18" version="1">MSLSDDSIQDAGTLVRLLDRYVAEPELQGDLVELLRPYRLALRSTPSLRSIYGDDDRFWPALGGLWREEAARLGRDENDSTVKAISALAGFTMSLCTQSPSNQEQAVSHIEPQLRRILLEASSFVNLQDPKYTDMTRICCQALANFVTANPRLAESFFAERLRLEESDKLLQRLLVSPDHGTIQAILIFILNSIHSDPERALLLGTSRGGAAVLDRVMTIVGTMFEDERADAMAQQHFTSDIFGLNFFIVQQLITQGAFEQAYASHALMPGYAISPTLVTMLKFLDGHLSLPEHASAPTSLALVPFLVRQLEHLAGSLVEDSSMQARSRDAADAGTFQGVVLVLHCLCSIGLALEREETAVAVEAEAGVQASRKMVDGVEAVVRLLGFSQTLMPPPTARPAPPDPTQAPAAATQSSSVASSSAYPASDSAADPPKEGAPSSTSPDGVAAIAQLQRTSVQYLGIVSFSPPGRYKDKATLERVKVAQDRVRLAGGLGLVLGMCQIDQRNPTMREHALFAIRNLLRGNQDSQDFVDAMKPEFRVGQNGELLDLPPALRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BES9</accession>
    <name>A0A2S5BES9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BES9"/>
    <dbReference type="STRING" id="741276.A0A2S5BES9"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015370714" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="213" mass="22886" checksum="456DAC9E19B55E16" modified="2018-07-18" version="1">MKAVSSSVALIVALVCALFAHSVSAAKGPVITHKVYFDIEHGDQPLGRVVIGLYGKTVPKTVENFRQLATGEAGFGYEGSTFHRIIKNFMIQGGDFTRHDGTGGKSIYGNKFQDENFKLKHTGPGVLSMANAGPDTNGSQFFITTVTTSWLDGRHVVFGKVLEGMDVVTAVENVPKAPGDKPKQKVRIAKSGELPVENGVDSEGKEIPLREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEY9</accession>
    <name>A0A2S5BEY9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1562</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEY9"/>
    <dbReference type="STRING" id="741276.A0A2S5BEY9"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="10">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="902"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="428"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="908"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="931" mass="102611" checksum="26BBD0237DE018E5" modified="2018-07-18" version="1">MSDIAGKLTEAAASSLQAAVELAKDNSQGVVAPAHLFSALLNPTQTATGQTQQTLLHSILNKAGAQPEIVQRGLAKFIVRLPSQDPPPDDVSLSPALSKVLREAEKIMKEKNDSFIAQDHLILACIQDASIAPILKEAGVTPDALKNAAQQVRGGKRVDSRTAEEGFEALKKYAKDLTSEAEEGRLDPVIGRDAEIRRCIRILSRRTKIYSIDNPVLIGEPGTGKTAVVEGLAQRIVNRDVPPNLLGRLWSLDMGAVMAGAKYKGEYEERVKAIIEECERAGESGSPITLFIDEVHLIMSGQGSSGGGMDAANLLKPAMARGKIRIIAATTLNEYRQYIEKDAAFERRFQQVLVNEPSVVETISILRGIKEKYEVHHGVTILDSALVAAATLAHRYLTARKLPDAAIDCVDEACSAVRIARESQPEEIDQLERQKLQFEIELHALQGELKRDKNDEVAKQKIEEAKQAISRIDDQLAPIKARFEAEKAKSDELNHVRKRIDELTAKAADAERRYDLATAADLRHYAIPELHSRLQQLEQQKKDEERQLRAEGGEALAGDTVTAEAIQVVVAQWSGIPVSNMKVHARGPLTEKQKLLKMEKTLRKEVVGQEKAVTAVANAIRLNRSGLSNQDRPIASFLFVGPSGTGKTQLAKALAKFLFDTPDAMLRIDASEYSEKHAISRLIGSPPGYIGSQDGGQLTEYIRRKPYSVVLIDEIEKAAREFHQLFLQVLDDGRLTDSQGRVVNFKNTVIIMTSNIGAAYLNELPDDVEDIPQATRDLVDGALRATLPIEFLNRIDGIIHYNRLRRKDIRGIVDIRLSEVQRRLKANGRDITLSVSDGALDFLASIGYSPSFGARPLSRAIQDNLLNPLSKMIFDESIRDGETARVEFDAPANRIVVIANHEPSMRMDDDDMSDDDELDSDGDVEIEEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF45</accession>
    <name>A0A2S5BF45_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acylaminoacyl-peptidase</fullName>
            <ecNumber evidence="5">3.4.19.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dipeptidyl-peptidase V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.1" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF45"/>
    <dbReference type="STRING" id="741276.A0A2S5BF45"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045550">
        <property type="entry name" value="AARE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19283">
        <property type="entry name" value="APEH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="10">
        <location>
            <begin position="574"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="799" mass="87079" checksum="7DB4D8B840AA235F" modified="2018-07-18" version="1">MPRDLDKTIRLTQEVLEQPSLTAARFLGHGDGQQHSFSVQLGFSQRSLSAQTKRNLAQTLHYTPGTADDQPNVIGSPLVETSSEVKHVAISKDGKLQALFRVTSAKEGKEARKVVEIVETESGRRVEELEVTKEHGDWYFDAPFGAPSWHPSGTALVYTAEAPPPKPASEDSSRPQPDKFNYTPDFGETFTGKREPTLFMLVLSTSPFAKEVDSSATKCALHRLTAPGLYGSAVFGQPAFLDDVQTPIVITTAYSPTDDDRKLGIVYCQNRRARICALELAVTDADEKGGKSDSSEESAKEKKRTWRAVEAHPISAEDRSARSARVVPATAAGTARSSQPRIVYVSNTLGGVHASCAKLQIVTLGSGFSVEEDKTLVPVVQTPQDLQGLVDFPGLYIDQLPVEPFLSPSESAGSTRILVTSTWRSRRVPIVVDLESGEMECLAPWPTTTGDKETPLPYLEYAQEDLSSYAGLATDGRSRVLASRSSPSRLPELVVCDLATKDRRWTVLRKPSLSTELAQALKSISHTILPLPEHEPSELILASPTKIEPKSSSSPPPLVVQPHGGPHSAATNEFSYSRAAAVIQGYRFIDVNYPGSTGFGQKTIDDLPPVLGTAEVEATLAAGRYLKTLGLASGTRAQTSLMGGSHGGWTACHLTARWPEEYGAVVMRNPVTDLVANASMTDIPDWCYEEGAFPYSLSGPPDHVSPEDFKRFYEISPMRHAKDVTTPTLLLIGLDDRRVPPNQGRAWYHALKKRGEKHVEVKMMTFAGNGHPIAETVEAEWVAWESGLRWLVKNTDFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF66</accession>
    <name>A0A2S5BF66_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Small monomeric GTPase</fullName>
            <ecNumber evidence="10">3.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF66"/>
    <dbReference type="STRING" id="741276.A0A2S5BF66"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="242" mass="26347" checksum="D7CB23BCDAF0EA45" modified="2018-07-18" version="1">MVYTPPPPGQGGAFRRKLVIVGDGACGKTSLLSVFAMGEFPRDYEPTIFENYVAEIRLDGKAVQLALWDTAGQEEYERLRPLSYSKSHVILIAFALDTPDSLENVSVKWIEEVRELCGPNIPVLLVGCKRDLRDQAMRHGPQGGARYVTSEQGQAMAQQVGARSYHECSALLNEGVDETFEAATRAAMLVRGEAAHPTSSSHHHHHRDDDVGYGKERRKNHHGDAGSDGEGGGCCSSGCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF95</accession>
    <name>A0A2S5BF95_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BF95"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="1313"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="782"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1457" mass="161431" checksum="99461FD8F4B7688B" modified="2018-07-18" version="1">MSDPAADSRTAPSERTRLLPTAASPASPRLRPSRPRSIRSIASHDPVAASSSRQGSLEPSDGASDRGGDGSPSKPGRTKRTLRSRLLFATIVVLLAVCVYASFVDDFMGDVEATISCGTCIALLAPLQALARIGDDAFVDLFVGFCTKLGIEDGDVCAGAVGTQAPILAHDLRSITLASPAAKNFCTTIFGLCPLPNTIPHTVNVSDRPAEAVAGDLAFSDRRARGHRVRKQWKSRGRKPFQVVHISDVHVDREYTPGASTDCSKVICCRDYGPTSIGPKVKFPAGPFGHKKCDAPPALVESMFRAIDYYVPNKTFTIFTGDVVESAVWSVPQSVVVNDLNLWHQDMQPVSYPVIGNHDVAPVNAFPRSSSPSAHASDWVFDLAARDWRKWIGHHAAEQVRKMSGCYARVHPGTQLKIISLNTNYCNEGSIWLRTTGRYKQNFWLYDSDVPVWDPNGILSWLAEELDLAEQAGQRAWIIGHMPFGKVDAMRDQSNYANQIFQRYQDTIAAHFYGHSHVDEFEIAYPDYKNRTVESANGIAFISGALTPTSGNPVFRVYDVDPDTYEVMDFVPHYANKTDPQYQVDPVWKPYYSARESYNSYLDPPHPADAPLNATFWHRVTEVFERNETVFQLFNDRLSRGGKIEDCSGGLCRKNTICMLRSMQSESNCAVIKPGLSFKDQKRDTDAVTEPQRDEERDPAIWALDHPEERYTQSRQHDYFACEGPGLASMLRMMGSGIGMPVEPGEARLSVLGGRWGAGAAKRLRKRKEDFSALGAFHREAKEAVDRHEREKKRRRKRAAKVASEQKRKPPLNGVVDVGAVDVAAADESDDDDVGPMPLPADAGAAVAAKKRKTLKHEKLYLDHLPAADRYNRSLMHRDTLAHVAVTRTNFILTASVDGILKFWKKRPVGVEFVKLYRTHLSPILAVPVSDDGKSCASLGADMGGRTAEGLEVKGSAKVFDVENFDMINILKLPYVPRAACWVHGRNDGRTLLAVSDFDSPLIRIYDGRGDGKPLHTLSSLHRASVHLMAYNSLYDTVISVDVSGMIEYWEPSEPFEKPERVEWTSKAQTGLYEFKKTKTTPVALTLSPTNDSFAILSLPDLRLTTFTFLTGRLHRAYDESLTAIQEMQQAGTAGVELDSMEFGRRLAVERELEKLALEAVIDGVRGSTASIGQPVWDEGGKFVLYPTLLGIKVVNTVTNRVARILGKDETVRFNNIALYQGEPEKKGVTTIAMATSENPLLQKKEERDPTLFCTAWKRPRFYLFTRAEPEDKDGERDIYNEKPTRDEMTIAAPAASATGPLSRRAVIHTTKGDIRIDLFPDQVPKTVENFVGLSKKSYYDGVIFHRVIPKFMIQTGDPLGDGTGGESLWGSTFEDEFHPSLKHDRPYTLSMANAGPKTNGSQFFITTVPCPWLDNKHSVFGRATGGFDVIHAIENVRADKGDKPLDEIKITSITLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFG0</accession>
    <name>A0A2S5BFG0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear pore complex protein NUP96 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFG0"/>
    <dbReference type="STRING" id="741276.A0A2S5BFG0"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear pore complex protein NUP96 C-terminal" evidence="2">
        <location>
            <begin position="441"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="975" mass="107130" checksum="6FCEEC9B713E711D" modified="2018-07-18" version="1">MARFGLHSDTESDASGRSSNGQQRRRDDADDDDILSTASRSDDDSQSESEQEAPPRQSLYDDDEAMSEEEELGDAADDDNEEDRSFRSQSTRSHSHSMRPGSQSPRPRRRQLLSPGATGTNSSRKPTQTTRWSNEPTSSSFRPGRTAVMQASLFGPSPEDQDYLQDNQDSDSGSDHERTHLRQPQPSRSFFSRPQQSPRQAEKAPAVEADDQAGNDADEQPLSAQPEFRPIRPTMLVPLAASVANNREGSLVDASLALGRSYRVGFGPQGQVVSLRGTYRSAAPLQAGLVHVERLQLASTSNTAKADAIRLLELQLAKTDIYPPAAPDLPSSSAPQAVPSEQLRFHDFANLFSDDDRNKDSRAGAHEDEARLFRLGACLFDEIADLALDEVDMASHGYVEAIRRRRLVSSWFEEAVASAVETDVSNLPAPSPSSPSASAKRIFALMSGHQLESACDAALDSSNLRLATLLAQIGPDALATDDQVRADVSDQLAKWREYRVDTFIDDAYRRVLELVSGNLGVSQGRKDLDPKGDSVNELHVLEGLGWKRAVAMGMWYGAPRSTGLAVSGTDAGLAEVVERYEHAYRADQRVAAPAPAYLQSTDSNASLPWPPAPASTDPLDPAFHLLKLFTSPTHALESALEPRNFGPSPLDYRLPWHLYLLLSRVLRRRDWEDRLEIEEGDEEDEAMRGHDGSKRDASVERTGNSVTADRVTEAYAAQLEAQGEWQWSAFVLLHLELEDCRIKAIRELLARHVDELDQPDEAEADGIQPENEKLRFLIDTLKIPEVWIYSAQADRALSSPATLFRAYMLLLAAQRATEAHAIAVEDLVPEALVRNDTSLVRRLLEPFLLDPPAGADASELQLEGDVSGWNEGGRTYLLFLAQPDRPDLLPRTVQAVQALSKRVRESNKLKGKRLLRLAVAEMESRLTVLAKANSASSALERTQPSLLAASDRAIWIQGANKAFWQNAIGAATAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFP2</accession>
    <name>A0A2S5BFP2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1202</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFP2"/>
    <dbReference type="STRING" id="741276.A0A2S5BFP2"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="57" mass="6653" checksum="14EE2BF82692A76F" modified="2018-07-18" version="1">MYRDPWAKREAWRKSPIFSQRAMFRNLFPGFGLGLAAFVAYVAYDETMNAAKKDSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFR8</accession>
    <name>A0A2S5BFR8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFR8"/>
    <dbReference type="STRING" id="741276.A0A2S5BFR8"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="213"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="562" mass="61593" checksum="3BEFDC1AB3B22468" modified="2018-07-18" version="1">MSMVASGSNGPRASNLFLPPAFTSSSEALEKQPRNASGYEWNERSNSSKPSQDGTASLSLEPDGQGYLGFASGATLLRILQIIAGVSHIEIPPGPPCDSSGWRATDAEMTACIDAYFSYYHVEYPLVHEATFRAQWNEVIPPPTGPGWQILTHVVLALGAFVSFRPMEAVDYFLERALAYVNVDCLEVGNLTLVQAFTLLSNITQKRNKPNAGSIYLGIATRMATSLGLHRELPSWNISLFEREVRRRIWWTVWCFDAGACITFGRPILLPAGEADVQMVHNVTDRAFTPSATSIPPSSPEPTMYTSLIHQASFHRLGNVCYNLVVSTPPAASSDLLSMDASLQQWKGGLPAWMQPTPEAGTAYPRFSFSAHKLFWRYSNLRIILHRRAFLERALKGAPLAPQPGSPEAADHDLDASCATLCLQSAADTISAIHQFLSSHRGGPNRLEWWYGLHFLFHASFVPLIALHADPTSPSRSSWLGLVSLTCTTLSLLSTEPLAQRCLQIIEMLKPREDPNGSLQLDTGILAEMLARSEWAGQDAAQNWLPFADLATLSSFWPAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG17</accession>
    <name>A0A2S5BG17_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG17"/>
    <dbReference type="OrthoDB" id="416729at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="328" mass="33841" checksum="B01A5C46364D664D" modified="2018-07-18" version="1">MAPAASKRALSHSQSSQSPSQGSQTRPSKRPRVRGPSTSLPATATSATATKTDAAPPAAAVRSSQSPPKAGASEEPGKTTTTPAPTRSQLPPPRKRTVHPGSLRRLSTGHPARTLKGASDPPDRTREKATLSGAKVGGKSKDLKDRVQAEELWIRRPNRKGARATTHGKQGLGYAGYLKMGVAAFVQRGCTTLTLHALGAAIPLCLSLALAIRDALPGGEPTTTGSGAPEDEPPLVQMEVRTGSKEVQDEITPDDEDDDIVYQTRTISTVSVMLSLSDPLRSSLGAAPAKDAGRFGRSGASMAASRRGRKRGGLNSRGGGGALGGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGA7</accession>
    <name>A0A2S5BGA7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGA7"/>
    <dbReference type="STRING" id="741276.A0A2S5BGA7"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="376" mass="40890" checksum="538FF0214C96FD7B" modified="2018-07-18" version="1">MADYWISRDKYFCKYCNIYIADDKPSRLHHETGLRHKGNYERYIRDIYKKGMQQKRDRAEEAKEVARVEAAAAAAMGLPPPESAAPVASSSKPKPAAPPKPADPYANYTTAASLGIRDEAAERAAAEAERRQNEGVIGEWQKVVKPRAPAPPSLDAGGDKGKRRAADELGGFRGEAVLRPGVEANGVKREEGDDAADRKPQVGATDDSEDIKPSQTAARPLGEREDDDDSTLETAKKRGFLSEKSALNDDDDDPLSNLAPIKLKKRRLTVKEQQAEEDKRLAKEREVEEVLRARAARDGQRGAWESVDPMGDEEAEYDPFAGTGAEGGQDKADGAAKEEGDPPVEQAAPAPEEVKPQPTALFKKKKRPGGGGLKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGE7</accession>
    <name>A0A2S5BGE7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGE7"/>
    <dbReference type="STRING" id="741276.A0A2S5BGE7"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015764721" evidence="2">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="464" mass="48985" checksum="63280FFE8D1053BA" modified="2018-07-18" version="1">MLRHVLAVLALWTLSAQALTLKRRAMQSGLGSQTALTQQQVDGIRSLLNQTADKSWEIGAHAEALTEFLYPDLSPFASASNSRFASPNPSVNPFPSLVCDIAGNVISQQPWGQWQLIQDASAADPASVGPAVILANWTMGEGQYATVGGRNQSGVGGAAEAQVWALLQQTPRASSGAISHRVESVQLWSDFIYMAPPFFAYYGLMAHNDSLIQLAYDQIRLYRQSLQDPQTKLWRHIYIPGGGNSGDSDPGLWATGNGWVSGGILRVLATIENSSNSTIVQAFSDQAGDLASWTKEVVDAAWTMPRNGGLFHNYMDVSSSFTDGASTAMLVASTYRLALMANLYSALSSSKPASSSLANAEASYQALTGNNNRHLSSSGVLSPVTDPMTFSSQLASGKVSPEGEAFVLLMESARRDWIADGGKIDSSAGNAGGGGTSSSAFPRAPRSTALAIVGLATLAVILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGG3</accession>
    <name>A0A2S5BGG3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_0913</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGG3"/>
    <dbReference type="STRING" id="741276.A0A2S5BGG3"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="13">
        <location>
            <begin position="28"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY75833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="198" mass="21806" checksum="77FFEB339D99502E" modified="2018-07-18" version="1">MPGTRPPAIQHDPSRERLDIAGHDDGPATPYPIYLHGWVTRGFGRGSKDLGCPTANLPDSSIQGVPVKTGVHFGYARVLGCGGHAEVYPMVMSIGWNPFYNNDTRTAEVHVLHDYPSDFYGKELRVVMLGFIRPEYNYASLDALIKDINHDKVVAATSVQRPAYSAYSEDAFFSKPTDLAPLPAGEDPSRPREKPQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGP4</accession>
    <name>A0A2S5BGP4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_1018</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BGP4"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="967"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY75934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1509" mass="164806" checksum="720705D7B0127427" modified="2018-07-18" version="1">MTADKALLQRWLTRLADLPQLALPTDYPRPSGENHLSMVEVRDERQLDHRTGAALLRLALYDEDEGISSDEDDDEDVEQTARGIQAALDSTDAPGTGRREKNRPTAFHILLAAFAVLLHRYTGEADIIIATSSSTSPEPLLLRIKLDPNDSFWSLVKSVQFLEAEAEADKISYDELLEALPGYGKEAQKEGGIAPPPVFRVRFIDQTEATDSSFLDSTSLTTDLTVFVSTTPASEPAQDASGSGSASGTATPTTPSLLRTSFQFTPPRISLTLSYNSLIFSQPRISLTVDQLLHLVHHVSSHPQDQIGSISLLTSKQRKILPDPKAELEWCGYRGAITDIFSRNAQSHPDRTCIVESVAPEQFGEKNVERTFTYRQIDEASNVLAHHLVQSGVQREEVVTVYSTRGGHLVVAVMGVLKAGATFSVIDPAYPPARQTNYLQVAQPRALVILAAAGKLLPPVRQYVSEKLSIRVEVPALQLTSSGLVLGSAPSVDQASSDVFAAVQSRASEPLNIPLGPDSVGTLSFTSGSTGIPKGVRGRHFSLTHFFPWMKERFGLSEESRFTMLSGIAHDPIQRDIFTPLFLGASLYIPTAEDIGTPGRLAEWMADQAVTVTHLTPAMGQLLSAQATSLIPSLRNAFFVGDILTKRDCTRLQQLAQNCRIINMFGTTETQRAVSYFPIPPLSEDATFLKTRKDIMPAGQGMINVQLLVVNRTDKNQICAVGEVGEIYVRAGGLAEGYLQLPDATREKFVENWFGQGVERVDAIAQMSDAEAPWKPWWHGIRDRMYRTGDLGRYNPDGTVECTGRADDQIKIRGFRIELGEIDTHLSRHPAVRENVTLVRRDKYEEKVLVAYFVPLVGSAELEGLVSGTDEDETEEQREGNKVSQTEVAKGLRRYGRLIKNIREYLKTKLPSYSVPSALLPVIVPLARMPLNPNGKVDKPALPFPDTVAAAAASVSGKGASKATTKQKLVPSEQIIHDIWLKLLPSPPAEIPLDDSFFDLGGHSILATRLIFELRKSLAPGLPLGLVFDFPTIRSLAKEIDSLRDADLGFAKSSGPNANGDAAGAADNEYSEDADALAKTLRESYEKPAPKDERKVVFLTGATGFLGAFILRDLLAVDRRGGQVAKVICHVRAGSKEKAMQRLRESGEGRGAWEEEWVSQGRLEVVVGDLEKEKLGMSEDEWTRVAQETDVIVHNGAIVHWVYPYKQLRAANVLATLAVIELAATTRPKALSFVSTTAAIEKSHYVRLADSIVQAGGKGVPESDSLDAGKTGLKGGYGQSKWVSERLVLEAGRRGLAGSIVRPAYIVGDSTSAVTNTDDFLWRLVKGCIQLGHIPDIHNTINMVPVDHVARITACAALQDPSHALRVHHVTARPAPRFNRFLAALKLYGYKVETTEYLPWRSLLEQHVLRVQDNALFPLLHFVLDDLPTSTKAAELDDTNTVALLEGFQQPSAVTIDDDQMGRYLAWLIAAGFLEQPPLTGDKGIRALPHLELQAGGARAIGRSSAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH27</accession>
    <name>A0A2S5BH27_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="4">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH27"/>
    <dbReference type="STRING" id="741276.A0A2S5BH27"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000006">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="6">
        <location>
            <begin position="68"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="358" mass="37639" checksum="7E139952276FD9DE" modified="2018-07-18" version="1">MAIQMSARTVLGQLPRRAFSTSRVTKNLDLYNKTIPNLRLRPDSTVICQGFTVLLYSKLGADHLVYHDLRTGSGKTATFHCKEALEFGTKLVGGVSPKKAGQEHLGLPVFGSVKEANNQVKPEATVIYVPPPFAADAIIEAIEAEIPLIVCITEGIPQSDEVRVAQALRRQTKSRLVGPNCPGIIAPSPDGKGGCKIGIMPGNIFTPGSVGVVSRSGTLTYEAVDATTKIGLGQSLCVGIGGDPFPGSQHVDVLKVFMEDEATKGIVLIGEIGGTMEEEAAEYLEKYNVQKKPVVGFIAGRTAPPGRRMGHAGAVISGGKGKAEDKVAALEKAGVIMVDSPAKLGSSLKKAMQEAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH77</accession>
    <name>A0A2S5BH77_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="6">2.7.10.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH77"/>
    <dbReference type="STRING" id="741276.A0A2S5BH77"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="677"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="736" mass="76868" checksum="17544ECF476CB1F8" modified="2018-07-18" version="1">MPSNPLPVNLPQECRKAQKIFQAFVDPHNGLDNVIPPSVLRRAKGFCLMSVAKAGFGFSARAGSGVVIARLSDGSWSAPSAVGTAGGGFGFQAGVELAEFLIILNSRAAVKTFMTKGSLMVGGNLSVAAGPLGRNVEGTGSLSAKGGVAAMYSYSRTKGLFGGASVEGSVLVERSDANAKAYGSNVTAAQLLSGSVDPPNWANGLITTITTLATGNVALPGGGWGLDSPMNTPTPGEDIDGDEEGYFSRARVEREKQRRTEAERDEHGLTPREYSERGYSFANSYAAGGSMGNKIASPEKEKSQIRSMLSGVGRNRSGSGSSKKSSKSATVASEDPFAGSIDDLPIKAPVSTGYANFETQFSSDFDVDSESRPTRPFSGTGSGTMSRNVSSTGVRSPSPGDSRSRGRDELMSFGDDKARNASASPSGSRNRSRAGSSASTGSSWFKRGSKTKVPTVSSGLRERAEQMKWGSDREGSTVLGSSRDNRDSFDSLDDEDAYGGRARFDDIGSRDQGRFRSSTIGASSGAGTVSAFDRAALSNQTRSRSSSSPLKPRGDDGKSPFDSNTSLSSTDGGAVPSRSDRNAYSAKPWDSEDDLFTSPPQLSHSARGSGASSPATITNGQRARSGTGASSASATNALDLRQVEADFAGVMQLSKHGGSGEVGSHSGSRSRSGTTGGGIGSAIALYDFPGVEPTDLPFKKGEVITILARDDEEWWKGRLRLREGLIPRNYVEAHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHC4</accession>
    <name>A0A2S5BHC4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHC4"/>
    <dbReference type="STRING" id="741276.A0A2S5BHC4"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="115"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA pseudouridylate synthase B C-terminal" evidence="8">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="481" mass="51927" checksum="1CD94145335F4B59" modified="2018-07-18" version="1">MQSIVLKLLFPLVPSYSRLLIGNGQSHPELSFTGTSTVGADTMPKARSQPLAALFAINKPTGVPSMTLLNNLQPLFSSSKLFQDPNKATELDQGANKKGGKWGRRGKGRGRDDKVKMGQGGTLDPLADGVLVVGTNAATKSLSRFLDCTKEYRAIGLLGCSTDSYDSDGKWVRKAGWNGITRDTVESVLGQFRGEIEQTPPVYSALKMDGKPLYEYARTGTPLPRPIPARKVTVHSLRLLRFDEGDQHAYEMPKEGLEEDKKKELARLEKMVKEGRTTVPTEEEVVEAPKQDGGESSEAVPAPADDAASTAEASTPAAAFSSTSEPSAARPPIFEIELTVSSGTYIRSIVHDIGLALGSAAHVVKLTRTRQGEFVLDPPSATTVLQVDTEGEANSEEKVEAEKADKQADNEKMNEEVAGGAAEDKLELETFSGGCVEWSLLEKAIAEHAAAKKEGKEVTEGRDADGWLEWERDLLAKCKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHL1</accession>
    <name>A0A2S5BHL1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHL1"/>
    <dbReference type="STRING" id="741276.A0A2S5BHL1"/>
    <dbReference type="OrthoDB" id="2596908at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015604760" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28109" checksum="27A00FFB8415AA8A" modified="2018-07-18" version="1">MRLISGPTALFCLFSLAWLAQLVSAAAAGPKPDTSLGASEPWERRRDLRIGHKYRLVKAHRLARSGKTVPSASLERSDPGKRDSMAPGQPFFASEQVGPRSSTSVLPTPDTSEPQTEGAKTTGADSSQLRPPKSTSRSVNLAGSAPASMTILPSSPSATTSATPNDPASLTSAPAMATTLSSEPDSSAPSTSASTRVLLTTMPGRTLAVFPIGLVVFGSLNGLLILVTLYMLWERRGYARQFEERKRQEKEQRQASEASSVVALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI28</accession>
    <name>A0A2S5BI28_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI28"/>
    <dbReference type="STRING" id="741276.A0A2S5BI28"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="682" mass="72007" checksum="AAA485EDD918BCB5" modified="2018-07-18" version="1">MASWDISALYRHSASVIVPSAGHRRDRIVSCHRERVVLRDLGSLQVIRTWTLPIALNSDARNKDNNSSAASPAAAAAAITTFTVSPKAPHYILAFVKQSNTAWILDPDQDGEKARIDIGAEGAVAMGWADALEPTVMSWSAHHLRLSLFPLGETTAASPPAFHILSPKVSPSPGSSSSTYAGHSFHPDGTFLVSLERSRPVSSTGSAASAAASSSTSSSLSLYDTISMYSARSGEAEWALVKSFPLPIAPAQAAQVDLAGVKWSPCGRYIAAWTSATDYRVYVMSPLGHLLGSFAPYADIVPDAPAPTAAKKSAASTAGRITRPNGKPLAKASNAGPTPAPTARAAQSDHDRSRSERSTSSYVGLGVRTVEWHPSGEYLTVGGWDGKMRILTRFGWVAIAELGLPAPSPGGAKIAAPVVVWREPAQWVEKTRGRGIVSFERPNLPYPLPTPIAVDFGRPNPRMGIEKLRFSPSGAWCAVLNPGYPTAMALYALPLPTSASAGAHMGTSTTASDEQQKSRKAARPLGRSRLHTILLFTADPANTDSTSSAVGDGRIRDFQWQPRPRTARDHDLDYGEETFAADEADKAEDDSETLVVVTGKKGFATWRSPRIGINGEEDQGVAECVGLPAQTDFASASLSFATPARGSTTMPLVISSSPISAAGNSEATFCVAYPVPATDAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI72</accession>
    <name>A0A2S5BI72_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0656</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI72"/>
    <dbReference type="STRING" id="741276.A0A2S5BI72"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000054">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="11">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="11">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="191" mass="21657" checksum="03A6445CEB0A77C4" modified="2018-07-18" version="1">MSTGLQERDNGLSFFLLISRQGKVRLSKWYTTMSPKNKAKIVKDVTQLVLARRTRMCNFLEYKDSKIVYRRYASLFFICGIGQSDNELITLELIHRRVGRRQDYRPSVSRPRSGSDPLFPPPHVTATSSCSTATLATIFNYEKAYTMLDELIIAGEMQESSKKSVLRAVGQADALEEQELAEDPLARLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIE2</accession>
    <name>A0A2S5BIE2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIE2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8214" checksum="0DC9144066156A4C" modified="2018-07-18" version="1">MSYPQQPQPAYYGPPQGGPPMQQYYGQPQPMYGQQQPMMMAPTQDQDRGGGDSGCGCCKVCCGCCAALCLFEMCCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIE9</accession>
    <name>A0A2S5BIE9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIE9"/>
    <dbReference type="STRING" id="741276.A0A2S5BIE9"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF24">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015745304" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="32238" checksum="6F08D95FA134F87C" modified="2018-07-18" version="1">MLTSLPLILSALVLLGSTSTDALPVDAVQNWRQLSVPAPNRNAVKRSVARGRSIRPRSSKRDVVVSNPKVVMNPKNPFYSSSLAAIMDPTIAAPLPSSSVTSVPTQAPTSDAVLTPATTEAEVQPTSSSATTSPPASSSTTVPATTRTSEVAVLPPVTTQWIPTTTTPSPAPTITTTTTTTTTTTTPPPSSTSSSVAPAPTSPATHVYTGGIATYFWQNGNAGNCGWYESDSTLLVALPTATYANGEFCGRYVEITRTDTGASIKALVADSCPTCDNDDCLDLSWGAFSALGGTEDMGIFDISWYFLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIG3</accession>
    <name>A0A2S5BIG3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIG3"/>
    <dbReference type="STRING" id="741276.A0A2S5BIG3"/>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15332">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15332:SF175">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015766414" description="EGF-like domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="820"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="844"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="889"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="903" mass="91414" checksum="3EEB2019D7D86D87" modified="2018-07-18" version="1">MLRESLFIASLLRLWSTALAATVTNSTGQATNTSDKAAVCTPDLCLVGANSLTAGLHVDLPYNGSTWQIALLPGSYTSSSPAFTGPTASDAPLSSLFTKPSTASSSNGFSTSGSLGGSASSAFNVAVQPGLVTYSSSLYQGTSVVVSPSSDASAANSSVTDLPTEIASLLLSSNTVAIASFANDRSSRLVLWESLHDAGELPSGAGSGGLDIEEVQASGCAKPCSSGGICTANGTCTCLPGFSGQTCDACSKGFFGRSCASCPAGCASCDDGINGTGICLDAPVSSIILPSSCNCVNGICSSNTTSATCECSAGWTAAANGTQCAACASGYYQTQSGECRACDPCCASCSGPNATCQTCQSGLQPDSSDGTKCVTATTASTNGTFITCPSRTFWNAASASCVDCNPLCESCFAAGTAGCLSCRSPNVLMPNGGGCVAYDSGTGVCNGAASVNSTVKVASGWVYDNDKKVCDALPPRCAAGGIDSFSPSSSRTSLQCSACLPGSYLVKGACLDSCPPGSMVSGDGKSCQACDSSCATCAHSPSYCTSCSSSSALVLNGTCTTSSSCPSGFFTSTTSLAAANNASSCLACHPDCATCSGPTSDACLSCPAYRPVLTAARTCVSTCASNEYYDKSKSKCVACDSGCATCSGGSASSCLSCPSGQKLRRGTCAAPTTAASKACSVIAGFGVCLEDLVTVAATSAATVEEDKRWRLRWWVILVIVLVVLALVGVGVWWFRKREQKRRRAHTARFAKELGDKEVDKKLAALPVSIAYPPIPRADTPASSSAASQHHLVPMSASEDPLPLAASHEVPLTPRFVLEDPASPISPSPSHFPPHLLAAPPGINSSSRWSLSSYGSNTTLKRDPPRTKGGSSETSPPGSPSAGARKFTTRAGNTLILQSRNPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJC4</accession>
    <name>A0A2S5BJC4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJC4"/>
    <dbReference type="STRING" id="741276.A0A2S5BJC4"/>
    <dbReference type="OrthoDB" id="288703at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="808"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="946" mass="100114" checksum="65A73FE7C9C895B0" modified="2018-07-18" version="1">MGKVRHRKRTREARVAATAQPLTGSTPAADSKHHDGTDLPPQGMKKGARRDADMQQLLDQLKSQDGRERTMASATLAGLVLSLPPLQLRLLLSKNLIGQLIERVAALPTTDAAAATPPPSHDLATAIESLGALRNLAVSAPAHLLSEMHNKRILTPLTAVHLPLLNRFLPVQLGPAPAQVKPSMPATPAARRAAEDLNEAHDTLRRSFWDWAENTLTLLWCLAESNTKILASLNQHATAIVGLCVAFLHGAIDLELEDGQAASGDKGKGKQANGAAPTKRSRVPLYVAVAAAQTLHAFVSSNPPAHSQLLSPPGSYTFSPALSVLLSILSSPTAPPSSSASSSSASSAAAETAEEWAQLRVLAFGVLLEIAKGRSKRRDVETVREQLRTDEAQEVLLELVKRAELSKAVEEGKAVAGQIDTTALPSRSTDASSPKARLASLERQAQTLQLALEILSEWLASGVPDSALLANAGEIEGAENDGLGDDEGVDREEEEWGGASGMMDVEDDEMLASDDDEREKDGVEAAGVKQEADGIIRRRRGDTPEPVVRGGDSDDDDAMLDDLAATADSDADDDDDEDLTGEPMNGAESGSVLLATSLPLQLLALSRPITALSFLPATAFTDSDTTKSNGLIGTSAVDASTAAFPAALSTLSEAITTIHVRALEALNNLYVTLSRGKKARRDSKELQEVFETALGLVQGALDAASKYVPPATAESATTGAGKKGKSGAVAAAAGGSGTQKQQEEEADEVQERRREVVMAGMGVVWGCTILGIDPERSGKLVVGPDTTPFLIQHVYPSPFAAAQTPAGEAIRVRAIGALGWVGRRQGVSKDENAQIGRFLLSLLPASRVAVVTNSAPSTVAATPDILLEAIDSFIDLYADEERDYDVPVFRQGGMLQELDKSVQGVRAAIKKIDKSKFPELRARADGNLNNLVAFVQYRKDILKVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJD7</accession>
    <name>A0A2S5BJD7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJD7"/>
    <dbReference type="OrthoDB" id="2529811at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="675" mass="71482" checksum="C15F4D38D7312826" modified="2018-07-18" version="1">MTSSRGQDYPAAHEAHVDHGAAAAAAQAAAAQAAYRREQDQIRASVDDLIAHLYHLADPLVQAQFEPSHLTREWLDSLPCPPGCTVRPEPSSNQQWALVEQWRIAAGTIRYYAQMTRDRWYEQQHQWAMAAAAAAAAAQQAAVNYQHRVDQAPPWSNPGSAFEADVRAEQHRLFGTAPLPDRVAAAAAADAAFLEMFGSGGGPVAPTTEAAGASASNLAEQEYDPHRGERHFAAAAEWYRSRDLANRHAHQGGQAFDNFDEEDDDDEDYEDEEEDGGQVVDDEDEGGGREFSFPIDLAALAKSAGMPFPAAVTANNNGKGPAGLTPSTYEDIVNRLAQAQAQQQQQQQGEGSAQVLPHELLQQLPGGAATLAALGAAAAAGNGSGDEPLNGILSDSSDPLALGPASLPSLMAAISELEQCVARLSLEASEARSLQRRMRDELGSGGGQQQQQITQGGGQDERERVALEKKKARNKKKKDKKRAKAALVAAAAGGDLTASGGESDSATGHGHLGAAGSDSVPAGGDLFAPADSSRSIELQQPPVPVATTLAVDSDGKQQQHQKKEDGELIKALQSVSMLDRRADEYRERLRVLKEQIHHHAALADALAASSSGGGNGASAPTLHTSAAAASASVPLFYDGAEGQEAFVGEYSEHGSEDEELYEEEEEEIEEEELVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZC3</accession>
    <name>A0A2S5AZC3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_7098</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000170">
        <property type="protein sequence ID" value="POY69900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZC3"/>
    <dbReference type="STRING" id="741276.A0A2S5AZC3"/>
    <dbReference type="OrthoDB" id="2017946at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023398469" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023398468" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="287"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY69900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="510" mass="52909" checksum="12ED13EF7752483D" modified="2018-07-18" version="1">MSAVSKSATPLKAAFAPALARFFSASAPIRTPSSATASSSQATTGAAGPATASAAKSNAVGGQAAAGSSGQAQQRTKAQRFTLDPATAPTQPKFPHGFLATGLHCGVKKDRSKLDLAVIISDRPCSAAGCFTRNAFVAAPVTVSKDVLARQNGIARGLVVNSGCANAVTGAQGLEDARAMSDQLDSFLSASSSSDGTGTLVMSTGVIGQNLPIKKILQGIETSTATLGSNFSAWSDCARAFMTTDTFPKLRTRTIQLGGKEVRMVGIDKGAGMIHPNMGPPGPPHATMLGVIATDAAIEPASLQSALTHAVDRSFNSISVDGDMSTNDTVVVLANGASGIHEISADKTPAEYEQFRDELTDFAAELAQLIVRDGEGAEKFVRVTVNGAPSYEGAHKVASTISTSSLVKCALHGQDANWGRILCAVGYSQPGFEIDPTKVSVSFVPQDGTPELQLLINGEPENVDEARASEILAEEDLEIRVELGLGDEGATYWTCDLSHEYISINADYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZQ8</accession>
    <name>A0A2S5AZQ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1/phocein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000153">
        <property type="protein sequence ID" value="POY70023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZQ8"/>
    <dbReference type="STRING" id="741276.A0A2S5AZQ8"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34118" checksum="7EC17F5840F8F9BE" modified="2018-07-18" version="1">MSASEATEAPMADRSWLASAQTSHAPPARPLPRSTSLKETVSRGDRLRKGTRYEDAYDNDPFAPIRGLESFSSASAVQEYIAALVRRDPHDVELLTQLPRIRYEDGESEGEPAVEAAVWVYEHIRRVVQDQHLWIATLMSDCTAQTCPEMQAGPDWYFLCAAHEVQPSPPCCAIDYISHTSDGAQALLTSPRYFPSRLSISESSRTLLSTVARRIYRSFAHAYFHHEELFVELESQTSLVRRFVALSRRFDLMPPDALIIPDDALREGGGGGLADDGNESDETERGDLHEERDDNHESELSIRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZY3</accession>
    <name>A0A2S5AZY3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Symplekin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZY3"/>
    <dbReference type="STRING" id="741276.A0A2S5AZY3"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="63"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="876"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1104" mass="120315" checksum="5BA06C30B9898193" modified="2018-07-18" version="1">MSYYAAGAPPVNGSPAPVASTSTDLELVAALSSPTTQPALKANAQAVEPLSRLLLGPADAAAKKVALAGFASAYPYLFRYALSSIYLESLRSGTEEADPGHAVDSFNSCQSGDSAQWTRVNALKSAVLHAWRNGAIGEKVGAVKVLQRIIQTQSAPASSDPRLARSAEPNISLCRPNHPFLKVAVLEDESNKLLEECITTLFTSPEADLVSAIVTSLITLIKSRPQYAQLVITSLTNWTPAALPSRNAVQVKSVEKVVKLSLQHLLKSSSGASFASQITPFLSQQAARMEKAVEEIRRQAEVEASRKRQALADELEAQQSKRRRLNPSREAAAAFTRGNSRGLDSVPSAADLPVQVVVETLVAALQKVPDPALAEAIANVRRHLETAAPAELAPKSREETPAVPGPAVMDPLKLDLGADELDIKAEVPVEAMDAEEEAPVESHDIVFDPITAENAADSTMAVPHDLSTNARDAIIMSALKRVCEAGPDGANSAVWAPLLSRLISRGLTPVEDATERDVESAERLRQVLFTFICGHLESRTELARLWLNEEWYAARRQTANTDRPYDRWLRRFLEHISVASSDKDKQLLQFLMDLPEIPKEEIYRLESMATNADQMQLGFSTLRELVIMRPSVRLAALDVLLGLSTHIDKRFRNAAITTLKKWVPDMPELSNTIRGFAISILERLGAPEASGIKNEEGATEQPGEGDGEADMATDATPPAPEPRGLHAEVRDARVVGRLDAPTTIDGVTQHVELLLALSVKDTSLLRPLFEQYGRMTPFAREALEELYVPLIRSLGLKHEGVLDLLGDFPEGSDKLVLKMLDVLAGKAKLPTDILALIKKVAAKRDLDSQFYLMILPECHKASSLQGEGSTIDTDDCEQDEIVRYLPRVVALLDGTPQRKAAIRSIFLSVIAPPAHFSSINSLRTRSDSLTPVELMMFLHQRDKDIGLKHTIEAISICFSMSDGFRPEVLAAFMQQVVDAPTIPNLFMRTVIQAVTTYKSLQPFVSTTLLSRLIGKRIWEVKPLWEGFVRLVKAIAPNSFAALLQLPHDQLREVVQKQPSLREPLRDYVSKKGGSNNARTAAVMEALSDAPDSGARSVSGTPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0G2</accession>
    <name>A0A2S5B0G2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0G2"/>
    <dbReference type="STRING" id="741276.A0A2S5B0G2"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="367"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="738" mass="82102" checksum="74651A00D3FFD725" modified="2018-07-18" version="1">MVDVSGDLVASATDNFVEVRSISTGRAVRESVLATETVISVCFAHDGRSLWIGTVEGSLQQYDVSPLRENAAKWVKLPVLGYRPDAHEAPVILIQRLRDGEMLTMDESGRLVIWQADANKGLPASLHSHSRTLSIPPRPCWSAILYGQLCAGWSPQSEGGSPATGSVRTFDIAGKVAVEHPAGATEWPLDKLGAISAGCAVPLHPGWVFLGHSSGHVSVWSTEKKAMLDVKRISGNKITAMVGPSRHLWVGDASGLVEVIDVFSPRNWRVLKRFEAHPGAITKMGVDAQTLWLFKEAPLKVPTYRRHHCASGLSVGTYCQDCASGMAFFVMIGSVSRALRAPCRWTNHGTPLAEALDDELPSYSDRSELKLGVFTWNVDGQPPDLLQSNAANREVLSAFVRSLDAPDMLVFNLQEVIDLSDLTLAARTFLFATKSHDVTGRYRHWRRTLLDAIASALPSGVPFRYTECKLVGLYQFVWWRTDTGYAISALDSAAFKAGFGETYGNKGCCATAITVDDTSFAFVDAHLTAGEGRQAARTLELTRYFDANPVFRRKATADGIGFRRGGDGTRLLDMETVFFCGDLNFRVNLPRAEVLRTLATSPHAVSDLLPHDELTALKHDDPSFRLRDFREAKIDFEPTYKYDHFSTRYDTSEKQRIPSWCDRVLWHNDKEDDVRCLFYRRYEADMSDHRPVGAAFVVRAYKINRLKQQEAHRNVLREWTNMEEGLILTARGYYPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0P1</accession>
    <name>A0A2S5B0P1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BMF94_6825</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0P1"/>
    <dbReference type="STRING" id="741276.A0A2S5B0P1"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00943">
        <property type="entry name" value="CUATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="875"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="904"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="119"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="POY70241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1033" mass="109492" checksum="1EBAF1E237DC6EB8" modified="2018-07-18" version="1">MAAPGEESSATSAFPLGDPHDDDLDVLSFAPSPSEKPSNSSSMLETTTLSIQGMTCGACVASIESGLSSQDGIASVKVALLAERAVIEYDAQRWTPEKLVEEIEDMGFEAAPVRLAKADAVQLHIYGMTCGACVASIESALRGTPGIVSAVVSLATERASVTYDPAVLAGVRDVVDIIEDTGFDATLAADENSAMQMKSLARTKEITEWRSAFLRALAFAIPVFLLSMVFPMVPFLRPLVNFRLVRGIYLGDVACFFLTLPVQFGVGVPFYRSAWRAIQHKSATMDVLVVLGTTAAFVYSVVTMLCAPSADDAAYHPKVFYETCTMLFTFISLGRYLENVAKGQTSTALSQLMSLAPSQAIIYTDAPTCTKEKKVATELIQVGDIVKIVPGDKIPADGLVVRGESAVDESMVTGEVVPVAKSLASNVIGGTVNGQGTFDMRVTRAGKDTALSQIVHLVEEAQTSKAPIQAFADTIAGYFVPVVVSLGIATFVTWMVISHLSNSLPHVFMEQGATKFMVCLKLCISVIVVACPCALGLATPTAVMVGTGVGAQNGILIKGAGPLEASHRVDRIVLDKTGTVTLGKLDVVGVKWTDRDDSRRTSLETDAALVGSPTGWRDDALLLSVVAETKSEHPLAKAVAQWGMRSLGLGSIPTTCQVRSFESITGQGIRCEVEGHFPSLSPDAGTGSSTHSIEIGNHSFIGQRLDLKLPQSLLSFQEREERLGRTCIAIAVDGTLACMISLADQVKAEARQAIDALRALGIEVLLATGDQERTARAIADEVGIAYADVQAGMSPNGKKALVQKLQQQGHRIAMVGDGINDSPALAAADVGIALCTGTDIAMEAADIVLMKADLLDVVSALHLSRRIFRQIRLNFLWATIYNLVGVPLAMGVFLPWGIHLHPMMAGAAMAFSSVSVVASSLTLRFWRRPRLARRADDPDLDAGEGALAEVSGALAQLLAASWRLVVPSGPRGGRTMFSISRIRGLLRGRPKRSDYGLLHAETALVDEGGDLEEGIPLVGAASPMIRNPGLMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0U7</accession>
    <name>A0A2S5B0U7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6582</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000118">
        <property type="protein sequence ID" value="POY70407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0U7"/>
    <dbReference type="STRING" id="741276.A0A2S5B0U7"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="75"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="229"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="318" mass="35125" checksum="6D9ADE316AEB53E9" modified="2018-07-18" version="1">MSGNRPEHIAPPEVFYNAGEAAKYTNNTRVQSIQAEMTYRCLELLDLPAADSAMDQDDDDGDDEEHVRARPSYLLDIGAGSGLSGEILTEEGHQWVGMDVSGGMLEVALEREVEGDLMLADIGQGIPFRPGAFDGAISVSVLQWLCNADSTAHSPVGRLLRFFTDLFGCLRKGSRAVFQFYPESDEQVKFIMNQATRAGFGGGLCVDYPNSSKKKKFYLILFAGQPIVGGKPQAIKVPEGLTDEHEGGTVSYEKKRADAEARKKLQRKRKSGGKGSRNKDSEGAKEYIMRKKELYRQLGKDGVPRDSKYTARSRKPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0W3</accession>
    <name>A0A2S5B0W3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6566</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000117">
        <property type="protein sequence ID" value="POY70419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0W3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0W3"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="920"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="979"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1086" mass="118350" checksum="80DA411F902CCE98" modified="2018-07-18" version="1">MPRLAPVTSRINDDYRMGQSRPGQRVSGARRLEQIPSIQLPAPVAPRARLPGEFRTLSLHVTETHTEEATHSRAKRSKDIDDIANLEWHSLSADEVAQRLGVAARAGLDGEMAARRLKDGKNVITPPRTNWFTKIFWYFFGGFGSLLTVAAVLCFISWKPLGEPAPQASNLALGVVLLIVVLLQACFNAAQDFTTNRTMSSIKSVLPTKVFVRRDGKVVEVPAEHLVMGDVVLVKSGDKVAADLRLFEVSSDAKFDRSILTGESLPVGATDAMTETNYMETRNIALAGTLCTEGNVVGIVVGRGNDTIFGRIAKAAGGPRPVRSTLQVEITRFVSIIGGLAATVVVIIVITWAAWLRHDHPGFISTPGLIINCVSVAVAFIPEGLPFCVTMSLSVMARQMKRKGVLCKSLTTVESLGAVDVLCSDKTGTLTMNKMSAVNIAIGDASYSVAEARRGETNAREAIKQLVAVAGICNEAHFAETEENMPFETRKVNGDATDTGLLRFAESITPVSELRSSVTEYDKLSFNSKNKYALKLVEPAISKKAIASVFGEGEDFVLLAKGAPDVLMPRCSAIVMPNGGVAPFTETAKDKLVALQSAFASRGQRVLLFAKRSVSRKEHSERIGTAEEKLVALVADLTIVGLVALVDPPKHDSRETVETCRRAGIRFFMVTGDFALTAAAIAREIGIITTPSHAVGSYADLSKSPASEKGSKSPASEEGSGTEDDAAIGAREPTSLVLSGPDILKLSEDEWTKVLQYDEIVFARTTPQQKLQIVKRFQDNGSTVAVTGDGVNDSPALKRADVGIALSGGSEVAMEAADLILLDDFSAIVTGIESGRRCYENLKAACLYLLPAGSFSELTPVLVNVFFGLPQPLLNIHMIIQCCCIDPLPALSLIYEKPEADLLDQPPRNRKKDRLVDWRLLLQAYGFLGFLESLTAMVGAFYFGFQRNGVPFSALWLKFGNYDVDPALMAELTNKAQSIYFYNLVCMQFFNLLATRTRRLSIFQQDPIFNPRTRNLRLFPAMACALALACFFSYVPFFQRTFLTRGVGVEYYFLPMAYGVGMLSLDELRKWSVRRYPKGITARMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B101</accession>
    <name>A0A2S5B101_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B101"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN / WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232:SF1">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN _ WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="186"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="694"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="1365"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="920"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="974"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1120"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1573" mass="168887" checksum="3567FC804030C4B1" modified="2018-07-18" version="1">MVDTNRGRGRRLPSSPAAARPRLNLNSPGRPTRPRAEDLQPSEARLSNKRPSAPPQIFPLSQVPTGPRQATTPRDLGDGQAGRGNGSTPRGSTRGGARARGRKRYTAGGWAAPTGPQYASPSVNGLPTRPGPADAGWAGRGGTSTSDKGKAPADARPPSGPLSRPSSSTFSNGGATPIPVPANPRCTLFVGALPSYITEADLQATFAPFGTITRLSLRSPKPTHTFAHVAYAAPEEALAALEALDGHQPTLVSSPPDGIEAEAGPSRGMRVTFAETPAERESRRTSTGGVGDGQLPPFGLFRVPQTPDPTQAANEVKHEPSPNPQKRSNDARAAITGPNRADQAHDFPSRLVPPTLSFQNRSIPSIGLGSFLPPDDMIRRPTYAFTYDYIRPLRSIPQKRLIEDLEDQLWRDHGRMRVESWSIEPRSHPTSIDLRVSVPADVVASYRQQHAQRSDGVGTAGGGEQETTITASALPPTIAPALATPTSSSFFDDAGVAHLRAALPETAIGDSADAKRQRKLFLVAQIRRLGEAGDKLVLNSRIEGDEVVIDYMLAEEEEAADVGDSVPPTRGSLLPSAADSNATPRPVAVTPETERMQDVKPIVADPSASDNLPAPAPPAESGMLAATDERNAAMDVDDDEVDQLATPPPGPDAVRFPLPLQPESRADSTETYTAVDAFLKECVSELLCLTRFRRADEALHRYFRRFDESRSSLESFYTANALLSVKIDTCRPARLLTPQVAFSPQWLAVQNKVASTPVAITNTIRLLPAVSHDVDRLVFTARTIPELHVKSKTRAPILLHIVGEFEEFLEKTVRSFSRTFILVPRPSKTAGNASDGFLVHSDQLAVKYAVSGEPSRLFVHDPPFTPGQKPHSENLRQRAPPTVATAVRRGNAADHVLPPHPLLARRRALLQSPVEARPLPAVPVASRAGSSPRDAGRSRDGGRTSSPEIAGIAAPASPPPRPAPQQVERLAPLELSSESESSSRSSHTSMSPEVQRRPLPMSDGLPARSANALGKRPAAAEASQAQARKKRVAQSETTSGSGALAARDAVEVAPARTYTAEELRRLVQQEVAAQLARSAAPGQDQSDATDHDDTSMASVGESRSASRESRRKDKADADRAAAAQEASAAAAAAAAAGERKRRAKEQAKAKEKKAKAQAASAQAGPPLGTGLGTSDARILLTGGAQSLLHGESDELLLSAPHADGVSRSGFNGSSNKLRHMVDTGSSYLAVSHIGDVVEFSPSPSTLSTTIRKLHSSTNDTYRVDDFAWSDAKDTLVVGFLGIRQGKVLEQPPNQIVLYKRDATLNGTRLIEDKVNVKPHQAGGVTALTTLPGSGRLRFVTGGEDKQMYIWSRSRSTQEYTTNEVRSNHSSMITSLTHLPERNWLVSSGKDKRLQAYDLEHLNSTWQALLHDPIMTVEPLSSDPFLVLARMSSSRDQFAAYDIRRPPTSSAVLTFGYELARESAATAFMPSSRADVKTAFCTAHRSVRGALASTNMGRYFRGAQCDTIFAFPDYAQGVKLWDLRNVRSAQTHLDLKRQEVADVGRSKVVQVAFRGRSEMCLMDQSHVTRVTIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1E6</accession>
    <name>A0A2S5B1E6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spo12 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1E6"/>
    <dbReference type="STRING" id="741276.A0A2S5B1E6"/>
    <dbReference type="OrthoDB" id="5578329at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="13443" checksum="5EF9F021A70B6875" modified="2018-07-18" version="1">MSAPTISFTTSSPAPSTSSAESIQPMHVAPQAQAQLPHGNGVPEAGHAAMTLGAKGFLAKKMAASGQSSLQSPTDQMVSPCTKKLAASKQRHFNKGKPLSLFQAQAGAPQQKKLSGLGQSSTLGNENQSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1L2</accession>
    <name>A0A2S5B1L2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1L2"/>
    <dbReference type="STRING" id="741276.A0A2S5B1L2"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015777046" description="Laccase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="216"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="340"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="606"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="86130" checksum="FD221FB6986F02AE" modified="2018-07-18" version="1">MKTGHGKDARTAGLLFALFTLIFFLTPFALARDLNTCPIGYSSCSGIKDYGPVCCPSGCACQRAEAGFAYCLMPSGVGGQQADAEQPCCVEGSYCIKTTNRWPICPEDGRAPARRLAPIIDTPLSGESRPAPHVGTARLPFARQAGSGSDDDIYDMSNDLLPTRVTPATGLRPWAPARPSATSKLSELRLSPDWDIYAAPQRREYFWEFAEHPGAPDGFHRPMLLINGQFPGPLVEVNNGDLLVVHVKNLLDQPTTVHFHGLIQNGTNWMDGPSGVTQCPIGPGASFTYEFPVTGDEQYGTYWHHSHRRATYIDGISGPVIVHSPYDPLRRGRDFDLEQIVFLQDWYHDPSDVIVDALLSPSGYNSTFVAPSPQSGLINGAGIYDCGASTRRGRCDQKTQRDLPVLVFPPNKRIRLRFIYAGAHPEMFVSVDEHILRVIEADDCPVWPVPVYSIPINLAQRYSAVLDTSGDSVGDSFYLRAHINTDCLDAPFPDLITQTRLIIRIGEDGQDLGHAIPTSRDWRDRTEGPCTDLDERILEPRVPIAIPEFAETIRYYNSSRIGPLNVSDEAGLAQGVDELLWTVNNITFENFAYDPLLHQIVRGENPFTGRIAIIDSPGLGAIDIVIQNVVGPPHPFHLHGRPFAIIARGSGTISPDEVASLDMNTRNPLRRDTLSLLRNSWVIIRVIADNPGIWALHCHILFHQAQGLLGALIVRPEVVRGFRIPQANYDLCRAGNPNMIDPGRRKRAVAEAEAMNVPPPPAHPRFKHAAILRRRPLLDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1L6</accession>
    <name>A0A2S5B1L6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BMF94_6351</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1L6"/>
    <dbReference type="STRING" id="741276.A0A2S5B1L6"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015635552" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="POY70645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="290" mass="31741" checksum="3A684FA4DD7EFCBD" modified="2018-07-18" version="1">MRVRTPLWTACAWLSTATLARAAFDCSPLTVGGHQFDLSQLEGVHEWDRESQTPPTVTKTRYSLSLCSPLPDPSGDAPDDDCPAGTRLCMRTFTSRPGLDDRILSVVPIVSNDADALTSKHGSSKTKDEWIFEMGGGKYNDIDQRVKIDFKCDPSAKETRPTVDEYDSEAGILYLSWTTFAACPASNEGGSDNSPPPKQDDESPPAGEDDGKSARDPVATGMGFFGWFITLLFLGFAAYFVLGAYHNRTKYGATGWDMVPHRDVWRDLPYVVSDLFKGRGASRNGYSSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1P8</accession>
    <name>A0A2S5B1P8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000098">
        <property type="protein sequence ID" value="POY70707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1P8"/>
    <dbReference type="STRING" id="741276.A0A2S5B1P8"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="232"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="956" mass="103060" checksum="E2B8473E5EEDEFC3" modified="2018-07-18" version="1">MLTRRLIRPIAFLKPNQRQLHASAPGLATLGLRAEDPLRRWERRAALDPEAVRQLVEDGHQILVERCSKRAIGEAEYTKAGAEIVPELDVTACDVVVGVKEPVLSTLPVAANPARKPAAHLAFFHCHKGQDYNFPLLQTLLDSSARVGTRFIDYELLTDAPSKDATRRPSAGKRTVGFGYLAGYSGMADGLAQLGTKLLASKGVATPFLSLERPIQAGTVDKMRQELERVGAEIKSGALDGLDRPLIIAITGRGKVGSGAHTVLEQLGVQWVEANELESLSKSSDRRTVFACHLDLSDYLVNRTGQSFDREEYREHPERYESVFHSKIAPYTTVFCNGGLWNPSSPRLLTTSQLAELQAHPSTSLLSIIDISCDFGGGLEFVQWATTLDDPIVQYDARNDRLHRDASDAHSIQLSTVEILPSAFPVDATRQFSKSLLPYIQKLLQDPSLAETPSNGLADALRRATLVRDGTLEERHRWVMDLVRKAGRRQKVVVLGAGLVAGPAIRTLSARADVDVMVASNDLAAAQALAAERSNVEAKYLDAGDPAAVTELVKGADVVLSLLPAPLHVKIAKLCIEHKASLVTASYTSPEMAALHEEARTAGVVLLNELGLDPGIDHITAMRLIEEARSTGHSIKSFISFCGGLPSPELSNVPLGYKFSWSPRGVLTAALNAASYRLSGKDVAIPGPNLLKENFPRLPLLRGLALEGVANRDSLSYLPQYGLPADLPTILRGTLRYPGFSRVVDAFKRLGLLDTSPLSQGLESPSTLLEACLRAKGHATTDGPSRQQALLAVLEGDEALATETLAVLQELGLAPSGRASATAEDLVKLPATARAPIDYLSIILAERLKYGPQERDIVVLAHEVTTEAPDGTPHLFTSSLVQYGTEEASAMATTVGVPIALGALLVLDGKIAQRGLVSPTSEEVWRPMLPALEQAGIRFVEGHRAGSRGILEVLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1R9</accession>
    <name>A0A2S5B1R9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_6134</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1R9"/>
    <dbReference type="STRING" id="741276.A0A2S5B1R9"/>
    <dbReference type="OrthoDB" id="1920692at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY70724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="89" mass="10015" checksum="4C24A83D60E0B230" modified="2018-07-18" version="1">MPVPYEALIPFGLLTVMFAVTGTGFSAAKRLTNDGKPTRHTLDQWEESMMERDRRLTGSLRGQSTEPIAPKAFATNSVWQTEKVQRTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B268</accession>
    <name>A0A2S5B268_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6059</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B268"/>
    <dbReference type="STRING" id="741276.A0A2S5B268"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="30570" checksum="6E2034349DEEAC2C" modified="2018-07-18" version="1">MSQPSTSSNLATALKVTGAVVGALAVATIGYAAVFDYRRRNDPAFRRKLMKEHKKVEKKVKQSEAVGKEQVANALKRALALVNAEKVPDSPEGKEQFFMEQVALGEQLAARSPEFYVASAISFYKALKVYPAPQELLMIYQKTQPAAVFDLVMELISLEINEATAAASASAGPSRGAGVGSLPSDPLLEEVEPEKQPQQAGSTAPVSESGSGGEDSSPSSGGSFVHVETDAVVTPQGEVEVEETTAVVADLEGQGADAAEEEEEEEKDEAAPAPVAEASEDKADPPEPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B294</accession>
    <name>A0A2S5B294_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B294"/>
    <dbReference type="STRING" id="741276.A0A2S5B294"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19520">
        <property type="entry name" value="RecA-like_ATAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="122"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="360" mass="39990" checksum="0E74366BFDDD4BEB" modified="2018-07-18" version="1">MAPSAQTKKLILDGSLFVLSQVAFYYAFKVIMNQVDPAKTKRKEAKNKSKEALGKLGIDLSTLDLNEHEEVIASEVVSADEIQVTFKDVGGLDPIISQLREAVIFPLCYPQLFESSAGLFGAPKGVLLYGPPGCGKTMLAKALAKESGATFINMKVSTLTDKWFGESNKLVAALFSLARKLQPSIIFIDEIDSFLRERSRTDHEVTGMMKAEFMSMWDGLTTTNDTRILVLGATNRPNDIDSAILRRMPKRFAIRLPDAQQRRNILQLMLKDIKVDKNFDFEALVRKTDGLSGSDLKEACRNAAMVPVREYMRQNVTGGQIDVEKMNAGKFNIRPLRVTDFFVSDYATPNGGSMEQEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2L6</accession>
    <name>A0A2S5B2L6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Alpha-amylase</fullName>
            <ecNumber evidence="10">3.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY70996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2L6"/>
    <dbReference type="STRING" id="741276.A0A2S5B2L6"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015527736" evidence="8">
        <location>
            <begin position="21"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="93"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="579" mass="65337" checksum="CE08D4EAB02F6B33" modified="2018-07-18" version="1" fragment="single">AARERSALALLAFPVSLSLSLSLLQFLTYTIDDMSTKPEIARKSSINAPTGPPVDAVPFDPPKPADQPKRTQAWRANARGLGKGDEEAGTTNYTACQAFEWYTEGNGKHWNWLKEKAPEFAEMGITAVWIPPPYKCDTKDSTGYSPYDLWDLGEFDQKGAVETKYGTKQELLDMIKAMKENDAVLNHKAGADRPETFKVIEVDQEDRTKEISEPFDIEGWTGFDFEGRGDKYSKLKWNFEHFNGVDYDNKTQKNGIFKILGENKGWNKHVDRSEKGVFDYLMSANIDVSHPIVREDLINWGKWLIKETGADGFRFDAVRHIDEVFLSEFVRAVRDDNDNCVGEFWMPDVDVINGYLDKFPEQFSCFDAPLHDNFYQASMQNENYDLRQIFDNTLVKTRPMDAVTIVANHDTQPGQTCEAPVGAWFAPLAYSLILLRGDGYPSIFLGDLVGCKSDPPVEPVSQLADFARARKWFAYGPTRDYWDHPNCVGWVREGDKEHDGCAVVMCNGTEDGSKRMQIQGNDEHKGEEWIDVLGWSGDKTITIGDDGWADFTCPAKSVSIWVKKGARGLDAFKNAPKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2U7</accession>
    <name>A0A2S5B2U7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2U7"/>
    <dbReference type="OrthoDB" id="2529411at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="459" mass="48143" checksum="8B3E6288F623159B" modified="2018-07-18" version="1">MLARSHGPRLDHNAENPGAFQHHKTPARPIAGKGAAPQAGPDTVGKGALLNTAWSGRVLGAKDRNLGKGEQDSTGLLFPGGKPSTSQAQAGPSSCAPRPVRQQAFKTPLPNKTLRQLAPQDLRTPATALRPKRAPLRELDSPDVSIDADVNEQPKEPEEEEDREVEYAGASARDYDEPYIPDWDEPDYKTAGYGDMLRSLPFGRFIDVEEALRQDQVELDSYRATLDEEIPPPPCLLDSEADQPIFPLPKTRAPLAAQPSTARPVQVPRGTSTGALGRSAPGSSTSRTPLGASGGSVRLQGSNAAPGSRPRPQAAAPSLIRSTLVKQSGQQQASASSMRPPAGAAPIRKPLATSSSSARPGAPVRPRLAPTGSARGLSSPAGSTLRSNVMSPAQLAAKRQADLEAAERELGAFGLADRDEGGLEVLLSGFEGDGLSQRGFGDESTGAGEAGEFRLSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B322</accession>
    <name>A0A2S5B322_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B322"/>
    <dbReference type="OrthoDB" id="10585566at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="360" mass="38641" checksum="2D311193FE3FA9DA" modified="2018-07-18" version="1">MRHRSKRTRNAAPAVKYWLTAATLSYLAGTALAAARVQPGRYDSAALARDPDLNDILETAIWPAVDAAAPVGYEQILERARRQVRLEQRAEEEKRERQRLAAAAAAPASDPPDNNEGTVSSPRIDEAAKGVVRVVRETFYIPLDADSSRADSSVRDVFRPLFTYAIHHPVRFVFAYLLMPILSLAWTIITSLLSLVVLILSPIRFLFSTFVLAPIGLAQSVVAALAPLLYALLGALAVGAGLGALGGLVAARSTRAALEGTVRTGSNALRWLGVLSKDDAGFRQTIRRYSTPATTVIGAEESEATTRSGESNLETPSSSGAATPVAIEEAQLVAPDEASVAAQKRANQLEALRHRVKVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B390</accession>
    <name>A0A2S5B390_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B390"/>
    <dbReference type="OrthoDB" id="10666331at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="376" mass="41002" checksum="FAA253387FFB162B" modified="2018-07-18" version="1">MSTSSLDCALEALPYEIKLVIIAHLAPTSSSPAASLRSHTYLSGLGRASPALYYDLESVVNSSINITERAQVARLVDLAPERIRHQSLPQLTELRIRGGVDGSKRELLESLRGLPLERLELRTLRLKDCSFAAGDFARVLARPLERLELPHCTGIDARTLADAILVSGVELRHLAIEAPASRSPQASPPSSPTLSARSTTSSPADSLVGTLLPYLEKLTSLRVVGDVLDEVDLAKLARQLPALRSLHLDSNPRLSLSDLVPLLSPTSSTRLPHLSYLHFQPADPASVGDLCLEPPLCLESPAEEQQRNSAIVEDLWRTASETNVELVGLPFREIRDRFDWAAKEVAKVRSCEDSSRSNFGSPARRRKRPSLASAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3D9</accession>
    <name>A0A2S5B3D9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3D9"/>
    <dbReference type="STRING" id="741276.A0A2S5B3D9"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000082">
        <property type="entry name" value="protein MTO1 homolog, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="6">
        <location>
            <begin position="610"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="717" mass="78127" checksum="F9A04784840145A5" modified="2018-07-18" version="1">MRLHRSLLRAALYSIPPRAGSTSAASSIATVAAAAPRPFKSKGPSRRSFATEAPGLCSNADIQPYDTLVIGGGHAGCEAAAASARTGARTLLLTQKLDSIGEMSCNPSFGGIGKGTLIREVDALDGVCGKVCDKAGIQFHVLNKSKGPAVYGYRAQMDRKIYKREMQSVLGNYPNLEIRKAAVQDLVLSPPVDGDCRESGRQVVGLRIDNVEIIPCKSVVICTGTFLGGELHIGMTITPFKGRLDEASAHSLSDSLREAGFELGRLKTGTPPRLRKSSINYEGLGEQVGDVPAKPFSFLTDRVANEANQVSCFQTSTNDRSHAIVRDNIHRSVHVRETIKGPRYCPSIESKVLRFGDKTGHTVWLEPEGYDSDLIYPNGISITLPEENQLELLRTIRGLENVEMVQPGYGVEYDHVDPRELKHTLETKRISGLFLAGQINGTTGYEEAAAQGVLAGINAGRAALSREQLVLSRADGFIGVLVDDLVTKGVNEPYRMFTSRSEYRVSLRADNADLRLTEKGRAVNAVGNSRWSAYESTKRDIESGIELMENVSMAPDWWNLRGFEVKRDGNRRSAFDLLHYKGVDVDRLLPLVPGLDALSPTVIERVGIAGKYKQHIIRQAHDIALFLRDENLVIDDSINYDVLPGMSHEVRQRLKDARPATLGQAKRLEGVTPASLACLMRYVRNGAVRRAAEAERVAPLSRGGFGRQSAASALVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3E7</accession>
    <name>A0A2S5B3E7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3E7"/>
    <dbReference type="STRING" id="741276.A0A2S5B3E7"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF11">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="500" mass="54038" checksum="8059BB674BB2F452" modified="2018-07-18" version="1">MGLLVKSLPPYTGPYAVSTVDLELPVDSPRSFGDAKLKSTGKPALQLDTVLVTLYYPADASRPGSGERQPWFERPLGQTAAGYARFAGQRPWLMKVFVYLFAANVRLPVEADRPIASTSAAAATAAGPPRTGSQETVVAEDHAPGAANGTFPVVVFSHGLNGTRTTYSQWAGEIASRGFVVAAIEHRDGSGPISTIRGDDGKQERVVDYIRPEDLTWPAGKEPLTSLEFRSVQLEMRLAEVKETLRALERLNEGEGASVAKSNRRRSKKSIGDQGLADWAGRLDLQEQVVMAGHSFGGATTFQVLRAGATSFPFKRGIALDPWADPIPPAPSLADTLSDSSFSPTDYKPDPTTSPSASKDSPPSLDIVTPLLVINSETFTLWKEHYKLVRGIVDAVKDKAPRWLMSMVGSIHTSFSDLPLLAPFIAKRTGARVDPQLATAEIVEACDEFLRSTYDGRILGQRVKEGDEVGARPGEGEKDETGRKRVMGGVPGEMRMHVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3L2</accession>
    <name>A0A2S5B3L2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3L2"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="60"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="364" mass="39395" checksum="8C1B0952B7D4DA75" modified="2018-07-18" version="1">MSNEKDVKLSVYGADEKDATSSDAASSLLGKVDSLPTANPERIATSLTSAEGVKKIWPGYIIAVWIALSSSVILQNAWILRTLQFNYPIFLTTWHLIYATIGTRLLLRFTHLLDDLQNVQMSWDRWLKNIVPIGALFSGSLIFSNFAYLSLSVSFIQMLKAFTSVAVLVMSVAFGLEQMQPRKFVIVIAISCGVALASYGEIAFDWQGFVCQALGIAFEAARLVCIQKLLTGLKMGPLVSLYYFAPVCAALNLMLIPFFEGAAPFQDALELVGWKVLVGNATTALALNIAVVFLIGCASSLVLTLSGVIKDILLVLGSVVIMGSTVTFTQMIGYAIALGGLVVFKLPKETTDKFLIQARGALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3P8</accession>
    <name>A0A2S5B3P8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3P8"/>
    <dbReference type="STRING" id="741276.A0A2S5B3P8"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="324"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="817" mass="89744" checksum="DF92950F9D513D78" modified="2018-07-18" version="1">MLSPSSSRTYVRIAFLAFVAVLASLLTARYKLEAPHDRPYGKPVTLGHQAFQVAFSRKPPGGPGTAQAGNQDETGMGGQAQDGDRWDEDALLDWANWNKQGSAAAQEWDPLRADSTPFTELQIKTCVLSPGVYDLCSPASSAKEDATRGEWQRIDKDVSKHVGVYYLYIYARRLMPGSDADVITDIRLLNHTAQIADLSEDGLWVEVSTSLREGVWPRMDPLFLHYKLSSQSSVRAARRASSDNDAGSLEPITQLDVLYGADEVSPLPGYAKIDVPITGGLDDPKRIGNGYGKGTRPGASLAYRRKSPKLPATPTLRFDSSGDFKVLQVADLHFSVGPGECRDVDPQQESECKRLGADVYSLRWLETALDEVKPDLVVFSGDQLNGQKTSWDAQSVVMKFAPLVYNRGIAWTVIFGNHDEEETDLNHEKQMNLMQHLPLFIGEAGPTSVSGSGNYVRSIRSPADSQDDRALFTMYFLDTHANVKKVNPWADPEYDYIKADQINWFRGRSSQIHSYTRPYRSDSRAVRSPLRVGSRREQGRLSRRQDGDGSWQEAAVAELQKLEKEFGLDGSLSPAVEPDDGSNIIQEPSQSQDDVEQDGSSDEAISDSDETSSAPATTSDFTDEEEELLEGADDREPTVLPAGPTRAQPMEAKPNAILWQHIPLPEAYSADIDVSPSGKRLLVGARYEGNGAPKYNSGFWEQGILAQKELPGSTDGVPIDSFWDGEGTSPTEGRPEVKVVANGHCHISSDCRRLSGVWSCFGGGATYSGYGSTAFSRRMRVFEIGDFGEKISTYQLTDARKRINRAALYGAGSLEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4B4</accession>
    <name>A0A2S5B4B4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4B4"/>
    <dbReference type="STRING" id="741276.A0A2S5B4B4"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="130" mass="15331" checksum="CAB1BBCE3FBC2461" modified="2018-07-18" version="1">MTTIPARLARLTQSSPSWDVARQRSRSLYRMWYRSAPEICQLYALNLPAHAIRAKVREEFERNAFVDDIKAVDVLLLKGHQEYQETLNCWKMDSHLMRWFAKEELPPRPDGFLESFYLSRDDSKEVQPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4D3</accession>
    <name>A0A2S5B4D3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4D3"/>
    <dbReference type="STRING" id="741276.A0A2S5B4D3"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="103"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="211"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="35654" checksum="FD15B8532CC72733" modified="2018-07-18" version="1">MAPKTAQLEPMNLVIGSAVSLFEVTTLGQPFEVLKTHMAANRQDSLRTAISKTIGRGGFKGFYQGLIPWAWIESSTAGAVLLFTSSYVEDFAVHHSGMSRGAAGLLGGAIGGAAQGYLAMGVCTRMKTAEVTRNKTLAKVAKGAAPGATAVPSTFGLFMEIYKKDGIRGINKGVNAVALRQATNWASRIGIARAAEQTIKELGHKKPGEPLTPMEKVTASAIGGALGCWNHPLEVIRVEMQSLSASSPSASVAAAPAINGVAGGAATLSASAAAAGAAVPGSSAPKVRSPTILSTAKYIYAENGIRGLFRGVTPRVALGVWRTVCLVSLGDHVKAMVKKDVAASGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4G3</accession>
    <name>A0A2S5B4G3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4G3"/>
    <dbReference type="STRING" id="741276.A0A2S5B4G3"/>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="54" mass="6039" checksum="76139DBA50E0B49C" modified="2018-07-18" version="1">MAGAHAAGGFHPHLPGMGYRVGAKFLGASMWFFIFYRARKDGPVLLGMRHPWEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4I4</accession>
    <name>A0A2S5B4I4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="741276.A0A2S5B4I4"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="347"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="349"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="792"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="940" mass="99709" checksum="B0CF68FCAA7A771E" modified="2018-07-18" version="1">MATRGPAEPSVLPINTAGHLASPRPVASTSSAAMPDNRSIAGHARARASISDLADITEQVFGTPNAYPGPPPSHFFPSVSKQDRERLKQARIAREAASSPAPSQRQSLGATAHYGQGGSRDRSPAAAGLPADQQRCTAQAGSPLISDQRAPGRQDQSGLAATGLFDPVRRPVANPTSQAEADAIFALQQAGVGAGGSGGTKRKIRDVERANWDAASELVRLESERASTERERAATSHQERRRPSPPTIAGQSPMSLDREKTPTPGMLLTAAPIPVDAPGGLDKGKRRSDPQSVDFALRRESTLTMSEASDGEDGAAMDDEDDDASVMTGRTGVSAGGNGSDTSGKEPAKKRSRTLTTPAQTAVLNALLAKTRFPSTETREEVGRQIGMSARRVQIWFQNRRQSQKRQREREAQEELAAARAARAIMSAQAQHMVGYPVRMHTAYDPAQGAFVQSAQFYPPLQPKPLQTEYILANGHGPPAGYHLVQSRAGDERLYAVPAAPPPQQVMIPIQTGDPRYPPTYIPAQRPSYDEEQYHRRMSLGGGGQGDIPVHVLPAPRHAQPIPVMQQQQQIFPSKLYFPHVPRQQISSAQRSGQPYAGQPVPASAATQLPQPPPSSASSNGEVKLPPISTMFAREAQSALPDSREAKPSVMSPGEHAPMFSHSPFSPPPPAHATISGLQSRQPLPSPGGAPQQSHHARAVFSPEPASSFERLRISGEPSRSAGGGYFGMADSSRALCFVDRPPSDRMQPPRDVLDMAVDVMADHSSRALPPRHVLPPLRSVFSDTFVKGSAAGASEADQALTRPIRPPGSARTESTTSASGQRLPPLSTLAAPASPQRDPALVSPLSNASRTTLSTAASFDFGRPPAGSYRAERFDFPGPSLVQSTSNSTISPQKNNGSAGESVGAEDEPDFWRDRGDSVGTGETSLASADTHGAPVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4P5</accession>
    <name>A0A2S5B4P5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4P5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4P5"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="85982" checksum="18DA5F43A96181C0" modified="2018-07-18" version="1">MTSLQAAHAEGANGLATIAEQSGPVEADEHGSTLSALAAASSSSHPGATAQAQSAQEDEAAGVTATTEAIHEEPRPSSRSTLRSSRSTSAGEPTAGPAGTTRRTTARPYAAPPGLAAEPEARREIFPSRYAARDAPTNHSSASVGKSSFSSLGAEPRPARISSDPPIPPEIHLLLMTTPPPPPPSSSLRHAASTKSTFNSAATPATRAGKRDPDLAVRRDDTVSSLTARMRSFRFLGGSGNEKSPQTASPQATSTDLTHASRRTGPGRMPESTTGTPEREKRRRTADRKGGRLDSRSPADFVPRTWSDYALAYALGHMDVSDPPFPPVDAQQLGPSPYDLAHFSAPLDLASTSAVRNRLLERLDLLGRNRRTSDAYSSNRSYGTPSLDTRRSSRASTTLSAVHTIPKVGAEGRQHPLSWLPSLLGDPALTALLSRALYAPLGTPALFKPSPKAAMITLFPPSSEPDAPVTIIASLNLPANLSIPLSHAIDAHVLLNGERGLVVPDTERDWRFRGNDLVCTAQSAAPGGPYTPSSSGTGKGLGIRFYAAMPVFAPSLPEIAGFEEEVSGRIAIGTIAILDDWPRLAKFGSSERSKLRSLASEVTREIERFLRDRGDLSRLSSEHSSPPTSTRQLPPPVPDVRSDPVDPAAAEQAAFFSGRIPAEDTRSTAQQNGPMAARCAVLADALDLSLVYVVKLDLSHCPPPPAITGPCQLALLAAHNLPTDSQASFDPSLHLRALRAPEGGLLFRSPADSPGKFASGVLLPIAETPAGSPDGVWGWVVAGYTVERDRKWGAKEMAAFEQARADLLPLLAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B536</accession>
    <name>A0A2S5B536_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B536"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="47" mass="5253" checksum="775AA24D80ABB7D2" modified="2018-07-18" version="1">MFIPIGEYSQSIWQVDKDKDGIVTEQRLFGVSYVPLTDAASQYEGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5B9</accession>
    <name>A0A2S5B5B9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5B9"/>
    <dbReference type="STRING" id="741276.A0A2S5B5B9"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="236" mass="25860" checksum="29DA46727424C1DF" modified="2018-07-18" version="1">MSLTSTASEPATVDVTKQGDVVQLDSVEDAIVAFRNGEFLVVVDDMDRENEGDLIIAAEHISQQQMAWLIRHSSGYICICLPTERLAQLEIPMMVAQNQDPHRTAYAVTSLMLTCGPNPPLTGTTTGISAHDRALTARKLADPETKADDFTRPGHLVPLRAVEGGTLVRRGHTEASVDLCRLAGLQPAGVICELVKPDDPNGDMARRDDCFKFARQHGLKMISIEQIEQYRQEIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5R3</accession>
    <name>A0A2S5B5R3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4854</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5R3"/>
    <dbReference type="STRING" id="741276.A0A2S5B5R3"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="362" mass="42110" checksum="A2E08E75B0B339EA" modified="2018-07-18" version="1">MATTSGRSIARIYPNANDERGKTWWDYDQLMVAWGVQDNYEVVRKVGRGKYSEVFEGVNVVSEEKCVIKVLKPVKKKKIKREIKILQNLAGGQNIVMLYDVVRDPQSKTPSLVFEHVNNTDFKVLYPRLTDYDVRYYIFELLKALDFCHSRGIMHRDVKPHNVMIDHEQRKLRLIDWGLAEFYHPGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGCMFASMIFRKEPFFHGHSNEDQLVKITKVLGTDDLYAYLEKYDIDLAPEFDDILGRYAKKPWMKFVTSENQRYISNEAIDFLDHLLRYDHQERITAREALEGHSYFNPVREAEQRSTNAGAGKIDEVVGSPQQQAASATSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5W2</accession>
    <name>A0A2S5B5W2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_4820</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5W2"/>
    <dbReference type="STRING" id="741276.A0A2S5B5W2"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="74"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="13">
        <location>
            <begin position="275"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY72183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="376" mass="39944" checksum="A7DC1962FABB0B13" modified="2018-07-18" version="1">MFHAAPTAGQRRWTIRVPASSANIGPGFDVLGLALSRHLTLRVSLSPCPEPESKVTLSYTGEGATDAPLDPYKNLITRVALYVLLSHRLTFPAAHVSIEIDNQVPFGRGMGSSAAAVVAGVLLGDALGDLKLSQDRVKDYALMVERHPDNVTAALCGGFTGSFLRMLEPSELSPAAIPLAEVLPAYPANAGPPQPGDDLPPQPPTNVGRHVRYGFSKDIGVVVVVPKFEVETAKARGALPDSYPRQDVVFNLQRLAVLTASLGASPLDPNVIWESMRDKVHQPQREGLIPGLSKIVNTMTPATHPGLLGICLSGAGPTILALVSNEGAAKPAAGEATPQMREVGEAIKALWQQDGIEVEWLPLEMDDKGATLEEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B641</accession>
    <name>A0A2S5B641_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000056">
        <property type="protein sequence ID" value="POY72205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B641"/>
    <dbReference type="STRING" id="741276.A0A2S5B641"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="82"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21284" checksum="07011748BF4B9876" modified="2018-07-18" version="1">MFFYKQLTQDLIMHPSYFNQALRGHLGNELRRQVEGTCSGRLGYIVAVVQEEVDASGSHRGRIMEDGQAVFSIKYRAVVYRPFRNEVVDGVVSSVNKMGIFVDVGPLQCFISTHLVPPDFSFDPNSNPPCFSSSEDTCSSTDNGQLSFRAPTLQLTIQKGTKIRLKIVGTRIDATEIFAIGTIKEDYLGPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B679</accession>
    <name>A0A2S5B679_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B679"/>
    <dbReference type="OrthoDB" id="2536507at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1021" mass="107533" checksum="229B43B5D35F35E6" modified="2018-07-18" version="1">MVAVSPSSVARAQSPGTSSSPSLAAKRICRQLVVEAGAVQSGVHACLVVLPTLTAAHDSVHLLDSAPLTTLAAAQVYPLPLRHDDAPLALEAARKLGLQLPPPLETAPRNGLPRTAINGDGHSSRRRSSAASNKSAALAAVRRGTPLVVEQKGEEIVLRTRACDQAPESASNGSTGADRDSTPGNDSGLGGEYLVVLHLNLAFGRLQLPLFANSVSIPTPLCLRNTLTLTLPSPPADSSFTAWDLSVRPSLSNAASILHTASSAESTQITGNFPSTPTLSLRWGPQLAVDSMAQLVVPHAITSTVWKVDDNAGMSAEVQVQADFEYAGLRDKQWVEVDVAAHSLEVLDCVGTGATNVLDWQLGSSADIPPPSSTPVPASASATPTGKPVSRETSGSSLGLGVPLTSALTLSAARRRRSSARVGEPRPPSFHSLFDTAMPAPPVLDTSFTTDLSSSDLLDQTRRKPSTSGRDPIVSTTAEAGRDKEASLLSQAAPFDPEASAMDMSFEIASLPDSGSEMGAESVMPDCSSEPAVSHEPAAKGASSTRIRIQLDLSSSLRAFAIDEAAERPTFAFQLVLAAHSSTAHPTDGVTIPAISFTTAQSEDGLVTVAGASMSDATSMPSAITLVDGSVRWTTSRRASADQNDFSPPVHLSLGQSSQKSATADGSTITSTVDASLLMEETPLAGEVSFGDSFDPDASFATLVPETPTPIDAEEESEAETSSKEPIRAVPAPDQGAPDHASAEAAEPVETAEQGATTWRAGLPVLRAREDAVSPEIVSTEATAQEPPAVAEKRFVSRDFAVQTISPKIVGSSVQTTPQPTAAPPLRRPLRRSSRRTEDSLVKSLTRLLFLVTLTLIGTQAWHYLRGGHASPFARYRSRHAHKYPLRPASTAYTIVSYKWSTTTMTETVHSTLTHVATVTSVSTTTEHRTVTSLHTLITPAVVPPKPTSSPPRPSPIYSDDFTAATPATPISTVLPPHVTSDRGLAPNEARTVAANFVIWLHSVRLEVRTLLSRWRDWIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B696</accession>
    <name>A0A2S5B696_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000053">
        <property type="protein sequence ID" value="POY72265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B696"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="485" mass="53435" checksum="F193DB25A21D0659" modified="2018-07-18" version="1">MEPSVEETAMPAPCFLIKLPQELLKMILSNLHPPVGSVKDKEYRELINSLLAAMHSCRTLLYAGRPILYREPVFFWAHSTVPLEASSWSYSTFASPYVDAAVSNSTVAAVVHDLPRLEVLIHIDPGDRDPISRGLLQKKALGIQSDILAACTQLTSVSVVLYDLDQAEHVGSLLAAMPNLSSLAISILHAGNKDEDAELYAACLKRLAPSGERALAKLFLVDYQGEDVEEFEDHESQDGPPAVGKGSDSAGEMPAILNRVTAALAIDLRRSHERDAVRSYLPDWAHSIEGVADGLTGVTIKYQWPNVAFTVDQDDMTILTAPCFESNRLTTIELEYEHEDYVASGVPRMESYANSFGRIAYSPSIFGLFHHARKLRLGWSRGLSLQHLEVLAAASPELESLELPSSLWSLTPAELKTDLPEQLSAFEQQLIKTLDRFSHLRRIDLGVWPYQGTSDDGQVVSGRPALQQWASARGLALKLERGFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6E3</accession>
    <name>A0A2S5B6E3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6E3"/>
    <dbReference type="STRING" id="741276.A0A2S5B6E3"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="238"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="384" mass="41621" checksum="8954D9D88E70430A" modified="2018-07-18" version="1">MSKELAGSSYHLFGLPSPVSPTLEDSSDPFLAAFKAEIAPDILNLTLSPPPLIRQLEEQADHLSAGLYPPWSSRAPVGGSRIRPDLHLDVSAAHAGWFSPPHSQDSRPLSSPARAVSPAIATSSLSGFDAGLGVGSPSAGLGLSFGVLPGAPFSHASNTQLEDYLVDRYEDEYGRSAGIVVQRRDSAPPDERSASSSGTTDTCSALHDGAHPRRISHGHARSLDSASPLDASALPPEKVTPFVWKLVKLLDQAQYAPWIMWDASGQYVLVAVGQDRLRAILSLFFRHTSLKSFIRQLHIYGFRRVPQGVLETLLIEQNATRSGEASEELHCAEYAAFQHPAFFRLPGGLDPDRKQLARLRPNAPPTRVSPVQRSTRSRPTSYEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6F3</accession>
    <name>A0A2S5B6F3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6F3"/>
    <dbReference type="STRING" id="741276.A0A2S5B6F3"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000002">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="260" mass="27912" checksum="C763BE12B854D6B6" modified="2018-07-18" version="1">MSNRDSSSVRDSVVSSTSRFSSLLSPSAAAASSSTSTLSQPGFPAAIGATTTATSTTGLAKRTAAIYDRPVTKSRGAEVSLGAWAFLFGEIVHYTQQRVSGISEFEKRLSILGYRVGARLVELVPLRDYLYPLSSIRSPPPPTRTLRLLPILTYVHSTLYRYLFGRPADSLERSTGNDDEYMIGDDDMVITRAIQVPKEMSDLSCGALVAGIVEAVLDGAGFPARVTAHSVPTPQHPRRTVILIKLEPDVLAREAALGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6I1</accession>
    <name>A0A2S5B6I1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6I1"/>
    <dbReference type="STRING" id="741276.A0A2S5B6I1"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="686"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1098" mass="121995" checksum="3C8BAEE0DE9E3AB5" modified="2018-07-18" version="1">MGRTKKSRAKGKVDANDGASSPPTTTATTKVAADEPDDADKNDETIPPEKRFICRHSGYGYCLVSTDHVASLVALIDQIRANRFTADLGPVLPQRHEVMLWLMTEATDKQIAHMKLFLRLHQVDSAVGGDMVPFLLEQIAGLFKESRFNDPSFAPKTVAIRRSATLATDSKGAKASSAESASSAEHTQRSEFANFGSLAPGVTRRIFPGVRNSTLRRIDRWILAAPTDKDERATNFAARHVLLKGTATEEDLDEAWEDIFDTMEDVDLKEDVLNVIRDHDDIREYMLVRFEELRGKCTCSDCFEIEPTSNADAGALYSVTDLDDEDYADVNAMIAYNAHFLEPPVALCPSNRTSLLKLAEARRSGDDSLDGPLDRNSLLTFFGLRKPHSSTPLHQLEPIRFKDMRVPKSHKGSYLLCRIISQPTYRNSVNFIVEDQDGRAEHVCIYNDVHEHRSTGWELDELYPLGQALVIREPTLVKMGLSPYTIVVRVDSPTDFSILPPSSTLMQEARWATVPPVEAKVETVDSLRIKGNDEFGDYQYDLALRAYSAALALDPTPEQRLVLALNRAQAYLRLEWNASCFRDASVVLAYLEQGVKGPPFAENKALLRRASALHQMGQWSRAAQDYERLLQLDPFQPAALKGKAALITATKQMLTGTYDWSAIAAAQEASSETVGEADFPIGDFVGRIAIDDVPDRAGGRGVVATRDIAAGELLLVERPLAVSTPPNEEHAYAYDLETHTLSEAAKADLVAELARMIVDDPRLAGVIYSLYGGTAHPPSGKLTSKLRAHAEPSLFALPADADIERLEAIVRHNAFNLESVQTSYVNYHEASESALYVAASGFNHSCVPNATWQVIESNISVRARTPIKAGEEVFLAYIPIAAPKALRTDVLRTHFKGPCPCASCEADDTANAFMRNDWLDKDFVDVTRTLIAARPSFSKKLVLRNRLRRIVEQIEALYASSSVSRHQLVAPMRTLSLLMDVNNLTDYKAVVDIELKRFECAGAQFSVTPTTVTVTSIPFDWDENVVREFFDLATRYGEAGLPAPDREVRKWVRAAWTATRIASGWTWDHFLQHYILTLDALDFSRYVEFWVPSLDINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6S2</accession>
    <name>A0A2S5B6S2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6S2"/>
    <dbReference type="OrthoDB" id="2533069at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="236" mass="25702" checksum="E6219EF6411A5790" modified="2018-07-18" version="1">MASTVASTSAATLRSTASSAGRRVNRRTARSSAQHAVASLAELYHLAPTFVPATDATRLSQHVTSTLTPLAQEASRPRPSDFRDLVTLNRRLDLERVRLTASRTLTPSLQAVDLATPANYSNDGLYNFDSAIGGRDAAADRFNYRASFYQAYSRAGEPPLAQRMRKVVDALHGTTAGGRAGPDTVREHGEKAVRWNRELEQARSAARDQRTRDEEESRAFQEAFDDEAAATAAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6T9</accession>
    <name>A0A2S5B6T9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6T9"/>
    <dbReference type="STRING" id="741276.A0A2S5B6T9"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="280"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="432" mass="48284" checksum="76B4BEA74E5E9191" modified="2018-07-18" version="1">MATEADETSTLYKSINEEYKIWKKNSPFLYDLVITHALDWPSLTCQWLPDKETPADKDYTVHRLLLATHTSGEDNNYLQIATVHLPKPQSELSIDKYDDERGEIGAHTATEPRVQITQSINHTGEVNRARYMPQNPDLIATKTVMGEVYVFDRTKHPSQPIGTECKPNITLRGHTKEGYGLSWNPLKGKEGHLLSASEDTTVCHWSVRGLSRLIPDVRGYTKGNSSLDPLNVCKGHTSIVEDVAWHNLNEDVFASVGDDRMLLLWDTRGQSGAMKPTSRVQAHDAEVNAVAFAPHNENILLTGSADKTVALWDLRNLKLKLHTFESHQEEVLQLAWSPTNETIFASASGDRRINLWDVSKIGLEQTPEDAEDGPPELMFVHGGHTSRPTDIAWSPNEPWTLCSAAEDNVLQIWTPSSTLANAEPAVEEIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6X6</accession>
    <name>A0A2S5B6X6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6X6"/>
    <dbReference type="STRING" id="741276.A0A2S5B6X6"/>
    <dbReference type="OrthoDB" id="2555515at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="76394" checksum="05D6CD797A003F7D" modified="2018-07-18" version="1">MTSETTAAGATAAPTATPALSEKALGKQRVVDQPIKASPTPATTKPTRAQAVQKRERRVTRSSRGGTDDAGTQGNAADSEGESLNYDETLPGVLPPAYLPARTRIVLTTKPPRNLVPFRPQRTDPLGETSQPPAIRPPPYPEATTSLQTANLGEARPPKSIAGPHNPLAKPPFRQLNEIELLPPRGTRHAAAEIDTSEAFYLRLHRYPEVLEKRASRLERERLIHERSKLMNEIEELRARTWVYAGTSAGGRAEEERQRKIKALSERLARYRSATPAHHSRVYDALLPNQPRKSNFLNLAGAGAVPPASNTAQNGGGDGRTASPSLQAPSSSSRRKATTNGTSSRQGDPLARPSTPVSASVSDSSGNKTTIRIKFGPPAVNASKVPSTDPDLDLERYTSKGELRKGPKRDRRAERARAEERRRLGLKPRSSIDKATARIDQNGEVVVASRLPPMLPRKDGIKRERRPSRSGVLYAETDDENALSDDGDEEEDELDEDEEMADPEKPPLLAQPAKLVRKRLPDSFFHSAALRDAVMASHGPNARRASSRVAYAFGQRLPDQALLQNVDFELRGGVAGTAEDDEPGHTRTTLEDLLQARMEQLGEEAVVLGGRVLPKSAVDAWSKDPLHVSPVVHRQRTLSATSDAPSSAAGSQFAAPLPPLLDGTTSANTPSTPRQVSPELTATPLFCSPLRRMSRPVTPELGTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B714</accession>
    <name>A0A2S5B714_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4384</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B714"/>
    <dbReference type="STRING" id="741276.A0A2S5B714"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="11">
        <location>
            <begin position="88"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="10">
        <location>
            <begin position="385"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="12">
        <location>
            <begin position="549"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="420"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="501"/>
            <end position="502"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="844" mass="91837" checksum="3C683FB63360A695" modified="2018-07-18" version="1">MDRLPIALHLSQDLLPLSGAGASGQGTSARGQQPSKVVGTGAGYGPPLPADGTPLSRLVSSVLYIPPREPTPAEAAQGWQPSRGGKTEYDLVAIPLANGNWQERWERMCTITASATEADLGAVAAGLTQQGEDQRIESEDWRAGGGFLRTEVNITRSEESGNLITFASDWLELDSPVEGIRFDAELALRQEIAYASYLSITTIIIPPPKLENRDFLADYARAINGALASSWHINISIRLPIAEYTAGELAARPGTPAFAALTGDSDRCETWEMWNTLRGLCGYSPRLTLMLDLSNPLPSQRSLGRWHAEPVRHIFLPCSSFIPNAKAYPVLSKSMQAFLKGIFRFRPTVVLSGTHRGLHGAGGHLAYAQYVRFLYRKSHELVPVEEYAQGYMDHLQQPLQPLMDNLEGETYEGFEKDPIKYRQYEEAVYRALMDRKQDSVTTIYVVGAGRGPLVAGCLRAAERAQRRISLTAVEKNPSAFVILQERSALEWGSQVKLVYSDMRSFNPREKADIIVSELLGSFGDNELSPECLDGVMRTLKPDGISIPASYTSYLAPISTSRLHSEVTNPAVASASTVVDAKPAEQPYVVMFSQFHMLSEAGGRIGVDKVQECWTFDHPRPDVVVDGQGLPFTNHHNARSAHLSFHIPRAGVCHGFAGYFEAVLYADVMLSIHPERAAGDMLSWFPIFFPLAEPVYLPANSEFDVQIWRLTDNTKRRVWFEWAAQTYLVAAPPSIGGAGAFDPRRASIAGTSPPGSVTSGTFSNHRFSGGSSALSPSLDAFQSAPSPHLGASVSAAMGVGGSGSGEHARMSAIVEEGADERDAVRIKVSQTRLHNPGGKTSWIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B740</accession>
    <name>A0A2S5B740_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1690 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B740"/>
    <dbReference type="STRING" id="741276.A0A2S5B740"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20954" checksum="6A70D2872C530319" modified="2018-07-18" version="1">MGAQGSKPDHEASPTGDDQTFFANRESPFSESLINHLSSQSTPSSTVPASRQQALDAHIQQRIASELQQLRQQEQQVREEIERALEKENLDRERGSSSSNGGDEASADKPALSHSASLLQDLEQLEKRASGLKKERAETNEWKAVDSGKEALERCFRENQQRPLDCRAEAEKFKAAVAAVEKAFFSTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B748</accession>
    <name>A0A2S5B748_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B748"/>
    <dbReference type="STRING" id="741276.A0A2S5B748"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="274"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="396" mass="41511" checksum="B70793E510D97313" modified="2018-07-18" version="1">MSVYIASAKRTAFGAFGGSLKSLTASQLGGHAAKAALAELPEGVKVDSVIFGQVLYSDPSAAYLARHVGHLAGVPVDVPALTVNRLCGSGFQSIINAAQEIKLGESHVVLTGGTDNMSLSPYTLSGASRFGTKYGVDLKLEDSLAQSLTDRVPNPTPMGITAENLANQYGITREQCDEYAVQSQQRWKKAFDEGAFDAEIAPISLPPKKRGGEPISFKQDEHPRPQATVESLAKLPSVFAKNGAVTAGNASGICDGAAANVVVSEEALKRYGIKPLAKVIAYHVNAVEPTVMGIGPVEGIRGVLKKAGLKMEDIDLFDVNEAFAAQWLAVAKELGLLMERSNVNGGAIALGHPLAASGARITNNLVHTLHRLNKRYAVGSACIGGGQACSIVLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B796</accession>
    <name>A0A2S5B796_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B796"/>
    <dbReference type="OrthoDB" id="3364747at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="186" mass="20733" checksum="5173B1A4AB32210E" modified="2018-07-18" version="1">MAAATTTTTHYSISEPTGVPGQVRLEAGTVERTTSPVAVPVQTQPTVLPTAHTHAPAEEVDSKVLKARKEQQKQLEKELDREEKLDAKEIEERKKEIKSVEKADEKAEKAEDKARKHYEKVKAKYDEALKDLKEAEAELNEKVNERQALAQQHRLAEMRVSEQIQAKQVHDAAREQAIAQGPAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7K3</accession>
    <name>A0A2S5B7K3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7K3"/>
    <dbReference type="STRING" id="741276.A0A2S5B7K3"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="122" mass="14079" checksum="1F88446BF467DB8E" modified="2018-07-18" version="1">MVRAKFKDEHVFEKRKAEAERIRAKYSDRIPVICEKAEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTGALMSSIYEEHKDEDGFLYVVYSGENVFGDEFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7P9</accession>
    <name>A0A2S5B7P9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7P9"/>
    <dbReference type="STRING" id="741276.A0A2S5B7P9"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="6">
        <location>
            <begin position="278"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="342" mass="38203" checksum="B052C2DCD44B1B87" modified="2018-07-18" version="1">MSDDAQAQQQAAELKAKANGLYKERKFDEARAAYEQAWQLYPKDITSLNNLGGESGLRLEQPEGNYDKAIETCEKAVEEGREIRADYKLIAKALGRIGNAYIRKQDYDNGIKYLNKSLTEHRTPDILTKLKDAERQQAEATRLAYIDPAKADQAREEGNVAFKAGDFAKSVTHYEEAIKRNPEDPKGYSNRCAALTKLMALPEALKDADKAIEVDPAFVKGYIRRAGVLFAMKEFDKALAAIELAAAKDTAQANTKEITQHFTKITNAMAESRSGETDEQTYARAMRDPEVQSIMSDPAFQMILQQAQQDPKSLQQHMAKNEGIRKKVEVLVRAGIIKTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7R7</accession>
    <name>A0A2S5B7R7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7R7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7R7"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025255">
        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28732" checksum="96D5FC0A0CBE843C" modified="2018-07-18" version="1">MAYEQTVRALRDIHETDPSYPSSLEYHESLVDYTRLLSKRSPIEPLHTASEALLLAANAQHVARWKRPRADYPLGLTGYKLWRTALNKFHADLLHETMLESGYSADRDAALFARTRDLLLKRTLQRPPLPHDVALLRDPEAHLFEDAICLTFLARDFAAFAAEYHAPPPTDAPPQTDARDTESTRALRAGGTDKLKTIVSRTWAKMTSQGRQVAVEQLVGTLDEDLRNVVIEAVGACEKQEDEQRATATGSSETKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7V1</accession>
    <name>A0A2S5B7V1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7V1"/>
    <dbReference type="STRING" id="741276.A0A2S5B7V1"/>
    <dbReference type="OrthoDB" id="2555434at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646">
        <property type="entry name" value="YALI0F00814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18070" checksum="BE910ED4DDD9A9F0" modified="2018-07-18" version="1">MVGHTNPLHLGHRKETAGPRTYRGHRRASWILEDQDALIELRARSRTFDGAYVRTALGHLYYSLIVLKIFSPEFAKIGLIYVIMSCLLLLIAQVRRRRSDHDFSDKYITEDPLSLPGVKASERLWGIRPFRTSGDTVILIGLVCSALYITTFILIMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B827</accession>
    <name>A0A2S5B827_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B827"/>
    <dbReference type="STRING" id="741276.A0A2S5B827"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="144" mass="15906" checksum="6ABDBD1CB63369D0" modified="2018-07-18" version="1">MSDNGSETPVVDQVEDVQVDVQETEAPKGKMSVEDALQQVLKKSLAHDGLARGLREAAKALDKRQAHLCVLNESCTEGEYVKLIEALCAEHKINLIKARACFSLIFAQSRISDPKLLGEWCVVVRDYGVESEALSVLLEYFASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B884</accession>
    <name>A0A2S5B884_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B884"/>
    <dbReference type="STRING" id="741276.A0A2S5B884"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="157" mass="17541" checksum="7933178B5BF4BB5B" modified="2018-07-18" version="1">MEIVQETSHMDRLTQTQNCIDDLIRIMASSLHYLSRNASFKQLDPNFPVTQSIPNADSPEQYDQNRKELVSDFLHKAKQLEYLIAQLPSSPAPASSARDDADTADFAQLETELQSVNDEYLAALDQAENLQRRLQASLNGVLESKRQQPATTSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B890</accession>
    <name>A0A2S5B890_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3979</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B890"/>
    <dbReference type="STRING" id="741276.A0A2S5B890"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="119" mass="13725" checksum="5B6A6EF687CE1C9A" modified="2018-07-18" version="1">MPPFASRPVKPSSLTLSLRRHPFTLFGLPFLSLVVLSSFALSGFTQTRYDYRDQKVTAVSKEDELGMRKDRRKIDVREEYWRMRSSGDIGESDEYENVRVARLPGQAEWGELPIAKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8N5</accession>
    <name>A0A2S5B8N5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8N5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="345" mass="37606" checksum="DEB52D052B0579F3" modified="2018-07-18" version="1">MPGQGFIRFPASQFDFVAQAPPSTLSPLPPRPRYGLPDRPNTSALKRKVPLRELVACRKRPCERPHVDNPLPKKPLVSIPSQSASRDAFSHEREDGEIVESAHPVASNDPFSYRRYDGFPPLIRFAPPLAQVVSEPVRPTPLSRKSEASPPELPLPSSNDPVATEERPLASDPRGQPPKASKTAPALELYAWAGQPVPSARTGDRAAAARLSLIASSAAYDAGGIAQPTKVNHLSVESAETGSISEVSVEAPAEKPVKKRHKTRSARGVASRKLYLARRSEKQAGCERALEQVQQLVWSEADSRRFDEFIYSPAPWVVDPDATEASIQNTIGILKQRSTESMVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Z0</accession>
    <name>A0A2S5B8Z0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Z0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="505" mass="54694" checksum="4C8563821D744A3D" modified="2018-07-18" version="1">MTSVQLSTGFNPRVVDESKSKPKYDLKCEAPGCDFVVKVRPTKLGGTETAEVNLRHNHEPLDFDEPDELDAEGKQVHDDVTECLQQARKAFKAKAKDEIVHLRDSADYRSTSTSDREAAGYLSYTSEQELVVWDLRDLLDENAARAFERAMRDTRQLADDYPTKSTLDGAAHPFLAPPEVRFPGSARGPAQQDSIKPAKKPREKPKKGKRARTDATSKSRSKKPRLEADATQDIVVTPEGEVSSAPNSPHINGFAAYANAPSPSEALRMLAVSGSRIYLESAQFLHRNEGGASTSAPDMPIKRAPSLLEDQGDVAVGLFASTLAQPQAALSSEAELAPQEADSAWLAFAADVFAGEDEAMSLIRESAPSPTLPGKAETPASATVSENALGKSPQVDLQAGEREDTAVLADAGPAMSKAGPAQHEPEEQVEQDPFAGYYAEVGELFDFAYRYYNKLMKTGEKAPPVQQPKDEQDALASANSLANDARATPLKMFERSLALRHKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9B0</accession>
    <name>A0A2S5B9B0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_3703</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9B0"/>
    <dbReference type="STRING" id="741276.A0A2S5B9B0"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="SWEET-like" evidence="12">
        <location>
            <begin position="544"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="SWEET-like" evidence="12">
        <location>
            <begin position="697"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="925" mass="100760" checksum="5EDAD4D6D77503D4" modified="2018-07-18" version="1">MDLPGPGGPPRTVVVQQQRPSLGYFLFLSFLFYLMNQQQVQTGELIRQAGDGDQRAARLYNRHRHQLLLREARRQGIARWLGIHNETTLEHEHGDWLVSKFYPDVANGTAPSLSTIANSTEDTAAADHQAYKVTPFVPQTEGELAPVHRLVTDLFSSSSHTTSSEPTAPQLYLQNLTGFTKGHWDRLSFSYADLGLNETWTEEVEREPVRKVGLPGPQPLTDDTPADASTSLTDDEADKLERRQGDGPVAATAPADTTEFKVVTYNRTDQRGTFPWASSSASSPRSESHRATFNLRSVQTSATGPVLSLGPDHDDGELLRLKDFSSSGWADWEKLGPVVYVGGKLTLHAPPRSSSTEEELTELDIEAVHFLDSGRVYGYATPDFARARIVETISLPLMSSTAASSSASPNLTATAIGHAMLREFDVRLERDVRRLADADVVEPPAEPALGAGGAGGAGQGTFDPDAEVVPRCIFTMYGALSPLPGSYPPGAYAEWYSDLFHPTGARVREPPPSTFSAVLASPNCGLVLSIPQAKVVPTQQLWNAAAVSGAVLVLVEALILLLQVRQLERVQGRPGTIANVSHYGVVGMLFVDAYTFVTLLTLGVVFDSRASLALLASAFMSLLSSLLFGTRYIAMIREATPDRPAPAPGPGPTDSATSPLLDAAEGCGAMAALPEWARSRLNTWTLRRTRRVVGFGSVIGFGLYLLNWYGWTALILWIIYSNWIPQIVLNVWRGTARQSLADEYVIGMTIARIAPPLYFWAYDGNCLLVPTSPKVWYLAAYYAGQAFILVLQNRIAAPQHQQTRLFLRLSTLGSGGARFFISPRLAKWLELPALSSWDYHPRSLPPSIVADLRGDVAGDIETGKLTGARPATPPEPDCPICLSSIHVFPTKEEQAAGEDDVVRMAFAVTPCAHLVHTECLEQWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAD2</accession>
    <name>A0A2S5BAD2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAD2"/>
    <dbReference type="STRING" id="741276.A0A2S5BAD2"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="43" mass="4449" checksum="290FF205F5747DF1" modified="2018-07-18" version="1">MAGAFGVHALAPSSGNKAATWGMANQYAILNGIGLQATWQYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAE2</accession>
    <name>A0A2S5BAE2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAE2"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29648" checksum="8209984D8F115678" modified="2018-07-18" version="1">MATSVNAPAPENPELIIRKLDSSTTIFSVPFARMGVVPFGGRSTAIKLQDGSVWIAASHPLTPSTLTTLSEIGPIKHIVMLDAEHGMYTKQYHDAYPTAKLYFPARGIDTWRSKGWLPADESQFFAFGSGCKPGEAVADPFEASTGGEIKSADFGKAFINEDIAFLHAPTKTLIEADLLLNLPPKEQYERSTKRSSLPFLSHHMRPGTRLHQRFIYSLASKDKEGMKAAAERVAGWDFDRIIPCHGDVIDTGAKKAWLDTYAWFFDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAQ5</accession>
    <name>A0A2S5BAQ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAQ5"/>
    <dbReference type="OrthoDB" id="2527117at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="410" mass="43249" checksum="2386DA264457EAB4" modified="2018-07-18" version="1">MDCSSSFNSFTGLETAIMSDAIGPRDVVLKGIFIHPAHLSAGFCADDSAYPSSVDSTSTLSYDDDEIVDLRESSELSEAALETLALDSAAVGSATQDATQDYFAPRPALHCSRTPLDGSPMYSGATSSSVWTPSACSTAATTPTAGSPGLVKGSTMMQPSSSRSGTMPATFSFASFTPNTSAEGTRHALPRAPSPSRPHPYHRLGSSHGTAMLRSVSSPVETQRQHEERQRRLVAAEDAMDTRAVKMARSKSGASTPAEYSSWGASASAPMTRRPSGMLVSPLSEVFGRDWGKALPPRPVENTPPLAFPYNVARPPVSPLRNARSRSFAGLSHPYEPASGPSTSVTSDSDSSTSAATMRALRPRSRLSVCLGPLTPIQTQSVESSPVTRVAPDAPFQSTVRGRLQRGMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAR6</accession>
    <name>A0A2S5BAR6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Far11/STRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BAR6"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="3">
        <location>
            <begin position="210"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="4">
        <location>
            <begin position="675"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1419"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="715"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="782"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1212"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1489"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1499" mass="163389" checksum="5F13B4B6FBA888D2" modified="2018-07-18" version="1">MVARPGLAVTVPDLTLRPLTTPADKPSPTSPVERERLRLTALQHAQASLSLSTTTSRLSPTTAAAAHQQRTAQLREPIATRLARLTTAAASLSDRTDQAMTAATEQATDVGAAPTYTESATDDTAAAAANDAQPETDTAPPAPPSTDAADPGDGGPPDAAGQQGPAQEGDAAPQQQQATDAGESPWNASSRLASLLSTPPPPPPPVPARPKQLVYTFPSPPADTADLLSELEEFYSYVEVPQVIEHYESWTGAHDGDEPPFPDLQQERQHEIIDSLLNTLLSHSSSSSDRHTAARHLLHIAHGTFSPEVCTSPEIHLHLILTNCRTLRSAGALPRLWSALKRTAREWEDLSHLPVPPDQDSQHGGDDQQHQHDNQHLHPNTNRNQAGRSPSAYSANRKAIDAQQEEAKAAERQERLDEANAELALLLAVLYFMTECSRGDDTWGDELMSLDPPMPVYLYNQVAGLRERNAKGYPVKKLLLLLWKSLLCTLGGMKDVARVKALVREVEGLPVDDSSDRPTYKPWTKASPPDILSFRNETLAKYPSYTPPSAGALLPLPAPLAPLADNPEMLDRISAAAAPIPVRPTFSYHINANHDPALPSNIPGPPPANWPHQPQPPTPAPSPPPTPPPIINQPTPPNGQGPPAKPKKQQFQTDQTRPFPLPFAPANAKRGRAVPRAIEEAGELYRRNLRISTELWQAWKVREEFRSDEMGWTKAAEVEREKEVYEREKKRREAIEASGVGAAAKAKLREDRRKARALGRRLEELALGDVGSDLRRKGLLESTGGDLSSSASSVKGGRGAPSGIETPEDVALDSDDDDEDVEDPMDPLTVLHNLMRQLKRDIKAEPDEKRRRELEERRLDVQRLERIERLYRMTLPHLQSAVIVLLKLLLATVTANQNLAGPTQNGEEPTSSDPPPDLSLEDIDILRHREITSKAVSAILILTLKWFKASHIMKFHYFSQLLVDSNCLLLILKMFGMQEVSTLVRIRHEKADQNFFRYCQDHLHPDKAERPEDALLAQPPAGDRAPSPAHSSGTNESSTGALVKEGAEIELVSDYSWRNFFSTINFVHILQKLTKRKTHRVLLMVQYKSSAILKRILKVSHPTLQLFVLKVIKSQVPYCGRKWRQSNMKVITAIYLHCRPDLRDEWLAGIDVDADVEESLPHEQALRSLVRFFNTQHYGQHAPGLHRRSSSVPANPNEPSPDFNPGPVASVPLPPLSPHGPPPDHPSAIEDVFPPPRAISAIDVDAKVPLKLAYGAVESAEDLEGYEVDDLLAASGRTAGQEGSATAVTAYKSALEGAGGSGVATPEGNAAVLGAAGGDGQVPQVSVVDHDDLLDFLNDPLGSSDAAWERLGLEGYDGEWDDVSDSESVGGWGFMRFGVDDKPGTTGTLADDGEEVLDEQSERLEWQHISPETITALEEERAAADAASPITPNSPRPPRNRRRSSTGPISPALRPVLIDRDDDGGASDDAPNADGEEGPAPVAPHEGPAIDEVELVFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAV4</accession>
    <name>A0A2S5BAV4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Structural maintenance of chromosomes protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_3031</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BAV4"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="1020"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="489"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="741"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="846"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1265"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY73861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1723" mass="188922" checksum="FDA4F36C26B85EA5" modified="2018-07-18" version="1">MPPRRPRAQAEPFDPVDTNARKPASGRSGRAAAKQGVAVVQPRPAKARTARATRAKVVDSEESEEELEEEEDGTQDGSDEERENVRPTRDQDDDDDDDRSSEEEAPVKQRSTRGSSVAAGRATRRAGSTASSASSGNLEDGRKASAARRAARLSVASSVATLDEDDDEDESPAPTRASRARRTPAAAAPRINGRGKKAAESVLPLSPSPTPSAADSASEDSEASDATAEGPAAADDSDDASEDDEEDVEPIPQRRKRVSLAPSAQRKGQPVLPTPEPDSSAAETEAEEQDDDATPQPPSVRRAAVKGAGKGKARAVVDSSEDDGEAEGPDAAARAKAHVEPPSPAPSNRSRSATPVPAEQPLEAAQVLTASPPSPVKSAPPTALTASALAAIARQAAIDHAAQAVERAEQMKGKPRLVIHQLVLENFKSYKGRAVIGPFHKSATFSTQSFSAVVGPNGSGKSNTIDALLFVFGFRANKMRQGKVSELIHNSGTASSSSSEDVTAENASNDGEDADDGFFDPEEYDSQDDEAYRKGGKGKGKAKGKGKKRAAASAYSAGGCDYATVEIWFREIIESADSVDDWTVVPDSSLVVARTVRRDNTTRYTVNGRNASPGEVKQMLLGRGIDLTHNRFLILQASIESIAQMKPKGATEHEEGLLEYLEDIIGTNRFKSMIEEAAVDVERFGEERQVQMNRVKLVEKEKGALETRKKAANAYLRDQLELVRLQNQLYQRHAHQAGADRMLYEEQAAEAKAELDDELERQKADRERYEAGSAEYEKTKAGLKEIEEAANSLAKELAVYEKAKVQLTVQKKAADTKHVKLKKQLEEDKHAAHQAQSDVRDHSDTLDKLIASKDQFRNELEQEQAALTKVMDSLRDKIEGFSLEIEQHQKSLAPWHEQIEAKSNEIKIATQQLEDLRGKSAQIQEDIERIEQEIDQDRAAASEQAKELKALKANRAELVKRVEQAERQLKSEKTVETKYRTVLSSAREKSIEAKASQQASQSKGQTLASILKLKEQGRLPGFHGRLGDLGRIDDKYDVAISTAAASGLDSFIVDTRETAEAIFDHLRKHNLGRASCLTLDRFGNVDLSPIRTPANTHRLFDLVTPKEKMYAPAFRHILRDTLVAPTWDVAQPVSTGKVDGQRWRVVTLDGNVAEKSGAAQVGGSRSIRGKMSSRIQADEVSPQQLAKLEADEKAAVVKLEEIVEVCKAAETNLRAVQKDIAHIDAAIPKLEMDIAASKQDSLQKAELLTELRSQSAPSAGDEARVAQLEKAIGALETDLDKLRGKAAKYEDQIAALQSKIEEVGGLKLRSQKAKVADLQDQIRHNETRLVKAKTERTKAEKDSAKAAKAIEANTAKAEELETEIADLRKQLAATEQEAEPIRQTVEEAQIRVEEGREQLATLKADLDEQEGAIIEFKKAEAELRSAFNEQEKALRESTRIFEHWTAKIGELELPDFHLLDTEDDGDDENVEKTPRIEDILRPLEADEIEAVDPRRLKGEISLIEERLERNNADLAVLQEYKRRDEEFRKRAEEFEAVTRQWEAAKTAVTELRNERLVQFMQGFGIISNKLKEMYQMITLGGNAELELYDSADPFSEGILFSVMPPKKSWKNISNLSGGEKTLSSLALVFALHTYKPTPIYLLDEVDAALDFRNVSIVANYIKARCAQQAQFIVISLRNNLFELANRLVGVYKVDNCTRSVAIDNTDLAAIADAEESDDAGTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBF7</accession>
    <name>A0A2S5BBF7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBF7"/>
    <dbReference type="OrthoDB" id="2523718at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41357" checksum="26BEF2120B90881C" modified="2018-07-18" version="1">MLRLTVVRLAQAPVFAPVAVRGLAMSAPIYNKASKSGRKVRWQTSSSPPPAVATTTPGQAGTDVGQGGTGLFEGEVAPATSESAEPEIPTPDQIEREMLDAQKDAHATEDKVGRPNLAGSDVAHGGEPEAAPAAKADDGVNRFGPEEVVYTAAPTYNPALMLSLCLVMSVFSFSIADFARVGVEQYDEETGEYTNAPAWKRYLLAGGAATIGTSLIVAGVWAPTRNVVKITLREKAGSMRSTPFPQDSLLTLYNPLTPIAQKVLRQKPRSAPVSKIHLLGQLSETPKSYHPRTPGPAVEPKKGALTSLFDKYFPPSKPSASRRTKGKYGHSPIVIEGDRFSMSLKTLRADEPFSTRGAWCKDWDAFERALLHVDESKWMSRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCS6</accession>
    <name>A0A2S5BCS6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCS6"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="557"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="866" mass="97658" checksum="01FF7D5DE893500A" modified="2018-07-18" version="1">MRPDGGPDRSLSSRRATVTEASAGHPGTTSATLGRNKFIGGNESSPTQPSPVPTVPTPVPSATGPIALPPASPRFDRLQSPVAPRLATPRMSAPSPRHHRKDSTLLTRSPAGFGSVLAGWLPFAGGPRSWSAKDRDGPSPLPTYGKRAGGSIPTRPFYPAEKRTDKRGYLLMARDVSLRPIYVLSRRSPVYLICALIVSVLFILNYSTSPSTQSVKLRVQGAVRPYIPQRAADAVQRYGKGGRRKKKLPKAGDAAAAAAAFREAQEPEMDRIQEDIRAEREQAARAAAKLAEKPRKRPTHADTAKLPPVGIDSRIPLEEGKPHPIPALMAKARRDWEELKGRQSKNFAEAVAEYKRRYGRNPPKGFDRWYAFAKSHNVLLIDEFDLIDKDLLIYRAFKPEVFRKRVTYLPEAMDTTWTIRVQRGRIYREGPLGHHDRAKGVEKLMARFAHFLPDMKIVYNGHDNARIALAAEERMRLEGLAKRGEYDDDENPPFDPKERGPFPNWGYPVFCPPGSPARELAFEGYGYHADLNATGFEMPPHPEGAIGSVIGDFKGYMDVCYAPHYRHTHCTTSWVFSHHPTPVLPFFSPGVQTTFGDIHALIVEQLELEAKHDPTWEERPFTSLQWRGQTSGPLWEKLTPWRTSQRARLHLLSHQEDGSRPVTLVDEDDIMHSTEMSNYRLNPLFLDTGMVGPAVQCVKEDGTCDEMYEVFQGYDKRISFDRASLYKYVLDVDGNSWSGRFRRLMLSNAAVVKSTIFPEFWTDWAIPWLHFIPMQVDYADMWDIMAFFRGGLNGEHAHDDLGKEIAVAGKEWVKQCYRWADLEAYQFRLLLEYGRLYTDETHPGSNDFDGDTSVEPKWNGPIREEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCU6</accession>
    <name>A0A2S5BCU6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCU6"/>
    <dbReference type="STRING" id="741276.A0A2S5BCU6"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="304" mass="33760" checksum="B238FFCD1DCF521C" modified="2018-07-18" version="1">MLGLQQLWPRAARNTYRAACGTCPPPPRPAHDSRPFSSSRPSNAAPALSSDVDHYKVLELPKEATRKQIKERFYDLSRKYHPDAPSTSSDSPEQRTARFQQLSQSYSVLSDPDQRRSYDLSRTGSTVPPHRRRPHHPGYTSATPGMGYDRGGRDDGAWTDNDERRTRANYAWQHPGRGKSAGDQAAGTAQARTDPFANRRSRAQPSTTDHFTMYADRAKVRSSQARANMGTNAQTGYAGPHTGSHYQAGTSVFGAAKAAEESRLINDSSTIRSGQVAFVFLSVFFIAYSLRHDDQDKKNSRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD84</accession>
    <name>A0A2S5BD84_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD84"/>
    <dbReference type="STRING" id="741276.A0A2S5BD84"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="154" mass="16723" checksum="A795E06CEE0E421F" modified="2018-07-18" version="1">MLWQLDQTHASRPPLDDSARSSASRRDSPRWLDDHAIGGTASNLCSVRGYLSLIAALLRCLSAAIGLAGCISTFTYYSAWTLLTPFLPDSSPLLALFPFPREWAIRIPALVILVGLSFVGMLTGSVLVQTAKRNGATLRGGRRRRPGAKADKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDC3</accession>
    <name>A0A2S5BDC3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDC3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDC3"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="286"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="487" mass="53665" checksum="18482538EDC0A859" modified="2018-07-18" version="1">MSAISQQQQQRQTAAQGWNQPTVRNRVPHLAEVLRRNTRPPVDLYCYYLFLQREGSEDTLDFWLDVQQHENLCRAYFKDLQKAGVAVSDDWPHIYGNVTGIRRGEHDASAASASSAYGGGEDESAYGSAPRTPYFDSPTETARDGSAAEKGRFETAGGGGEKPLPSPTPSAGGLLSPATSDYGFAREQLRTPSPQPGQHVSQYPLSPTLRAMYPHDDDAGEFGASSAQAAAAAESQYPGSGNTLTSATRRRLGAARRSNTNGSVGNTQPFIMRSSAISRTDLIASAERIYTRYLMPGADKEVYLPPSLRITDFPLSRSTLPAVTHPDYDHEASLQAKIPDLFHQQKEFVYRAMEQDSFPRFLRSKAYGNLTPLSAYARLAFGLLALWAAFATGFAFILLDVTPKAKRLWVILPFTFAIVNIVAWGYDLDPLMVFMGLSETTPFRTIGIREPYIRKLLFARALWIAFLSAVIVAILTLIFVLVPGHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDC5</accession>
    <name>A0A2S5BDC5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDC5"/>
    <dbReference type="OrthoDB" id="2527251at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015759993" evidence="2">
        <location>
            <begin position="20"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="361" mass="37584" checksum="7FE64AEB6EBE3095" modified="2018-07-18" version="1">MKFTATIAALASVVAVVRAGGSIDNSAVAGQIASAASTLNGAGNYVLTNVATGQTLSFSRSGVTNFFPQAGNDPVSIQFNGNQARISGGNNKCASAQWDANYEGGVDYAAVAYACAVGSGPLTGTATLERTKQWWYLVPTGDSAAPAATPATASSPEPKAETTTEAAQAASATPETQAYQFNNADVQAKAAVAPAASSSDAAPAPSSNSKQATRNPAGYWDSSASTISLDGIDTSKVNRQDRSTWICRHPGWWLANHPNYVYTAGHVECASDLKAYLASQQGQSRMGKRSHLVTPSHQELAKKLAKRGSQSYYIIAVDHIHDMATRAIGSGSLSTFGGYTSTRLDLWNKGNSGQMWTISSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDC9</accession>
    <name>A0A2S5BDC9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDC9"/>
    <dbReference type="STRING" id="741276.A0A2S5BDC9"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="259" mass="28667" checksum="96DFA8DA6CF335A6" modified="2018-07-18" version="1">MAGLDDLPVELLYEIHLQSLSSALPVVSRYFRSVFAATSPFHRSEYLYLRHDRKTLAHAVKYGICDLKVVRVLERQAKTRGKKLKCPQLPRRLFKGVGHAKDKSAVDLPLISYLLAEYDASPNSHDGYPLARAVFARHLPLIKLLLEYGADPGLKDGWAVTTAISNGDHDLVKTLMEREVERDEPTVEADVLVPTPGSGSGKKRRHDSGGGGGKRRKIGDRCLATSIMLETAVRSKQWAIVDYLTAKGARPSLNVLTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDI8</accession>
    <name>A0A2S5BDI8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDI8"/>
    <dbReference type="STRING" id="741276.A0A2S5BDI8"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015765412" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="431"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="692" mass="76313" checksum="3B5AD668169114E0" modified="2018-07-18" version="1">MKFALLSLTAAACAPLLASAAPQFVVQNGERTQSRFSPPRDDGAAAAGHRLADLTVDDFQAVQHAIKDTFEHSVESAKHLVEDTFHIEVDADDEEIAAEGFSFPHPPSHPLPPAVIDLKEYTIFEIVNASLEHHHPHCGHGRRDADEERHPSARDRKIRSGLAAWFTNSRDDKDALSEHGKPNPHMLPLHRLAWLANFSSEAGDLLKQKGPITLLAPDDAALTPPHRDHREPHGGPHRGPRDGPRGGPPRRRRGEHGPPPPPPHHDEIMSLENAFSEAAPHPFHSRAFSPEHLAKLASGDDDDHERKKEMFKKLIAIVARYHVIPEDAADPHELADRATLPTLLTDERVRVSPALRGFPIPHPSLTFNVYAEKRGPTILAKNGVIHLISAPLLPPFTPLNQAFLTPQYFGALTNAIQKADLADALVPQHPSFGDAEVLEDEHVPSLFAEMIEELAAEKGLNEYTIFAPSNYAFGRLGYEILAFLHSPFPISKKVLGYLLSYHVVPGVTFYSDFYKTDKSLTAAALEVSEEIDVQVPLDLLYDGPHPPPHFPGHTPSQRGNITHYKLPTLLTEKNENATLRVDVISYRFAGKGPIRRSIIVLPAHHEHHHDGDNEHKPERLHEGPGGDGPLHPHPVKVAFTDVPARKGAIQVLGRDILLPPPPPHHHEGGDNASAMSQHEAEHIRRALRKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDQ5</accession>
    <name>A0A2S5BDQ5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_1880</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDQ5"/>
    <dbReference type="STRING" id="741276.A0A2S5BDQ5"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001201">
        <property type="entry name" value="ATP-dependent DNA helicase UvrD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="15">
        <location>
            <begin position="52"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="16">
        <location>
            <begin position="356"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="597"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="857"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="898"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1014"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY74904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1064" mass="115459" checksum="0E43B12F82527A9C" modified="2018-07-18" version="1">MEPPDDLSDSEYDKTAQQASAATRQPAKSPPKALKQLKLNHDRLSPEQYLARLNQAQQEAVTASPEGGLAVHAGPGSGKTAVLTTRVAYLVEVRQINPEQLVVVTFTNKAANEMKLRLCKMIGPETVDKLVMGTFHSVCVRYLRKYAKLVNLASNFLISDRDDCLAIIKRLLSTLPAIPEKLKKEMKPNTWLEYISRCKSKMQNPDQYRVERAGDWDQDKVEAVATMYEAYEDALNKANALDFDDLLVKGLELFRDHPRVVAKIKSVLIDEFQDTNSVQYDIVKLIASASNSLTIVGDPDQSIYGWRNAEIENLEKMLKGEASPIDRRVRKLTRTLRADFKPIRQVFLEQNYRSTGAILGAALAVVRQDTKRINKSLTTSHPSGSSVVLHPAPNAPDEATFIASTIRHLMAHLGGLVNYNDFAILLRYGALSRNIEVALQKSGVPCRMVGGHKFFERTEIKDLLSYLQLVSNPSYSPALARVLNVPRRGIGDKTQAQIFDVASQKRESAFEVCVRIAKGQSVVSGLTGVQKKGIKQLVEIVRDARKRADEGSDVASLIDLIVEKIGYRAHLDRTQSHDAAERWENIMELKNPTTADLATAADGDEPGPQQFDEVQIETRSQKTKKEDEDLFFPDDPEDEEDEEEIDMPLASQRATDAKTTPLEVFLATSMLATDTDTQEAKGDAQLQKVTISTCHAAKGLEWPIVFVPACEEGTYPFYRSVEENEIDEERRLLYVAITRAQSFCFISHAAQRMAGADMKTKRLSPFVETAKRDFPSLFVQKLQKISTKTREETAKVIGRPAVDEAIAAQKVADAATLPVEPPIWDASAPPAGSRNYGGYGSGASMYASQGRYGGASQFGSGGGGGRWSGQQPPQAVPAGQGGFRSALSTFKGAGAGAVNNGFSRPSSSAPPRTGFKPPIPSASLPQRTASLGTPAVRPSLAATAGIPLAPIPQSRPAVDGPPGIVETRGSLVNEAVLLNPKLSAPGPSKSNDLLASFQKGAEDDLNTFMRLGAGAVPPAEPDTAPIPAPVGKAPPMSPKAKGGRKRAAAPAATAAKATRKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDU6</accession>
    <name>A0A2S5BDU6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDU6"/>
    <dbReference type="STRING" id="741276.A0A2S5BDU6"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22064" checksum="3D7836E057CB8682" modified="2018-07-18" version="1">MLRAFLDWLRSLFFAKELDIACIGLQNAGKSSLVTVLTDNHFTEEMIPTVGFNLRKIQKGNVIIKVWGQPRFRSIWERYCRGVGAIVWVLDSADASTFPTAQAELHALLDKPELRGIPLLVLANKNDLPDHATVDEVIKALALTTITNREVSCYSISGESTRHAVLGNRALTDMLAATLSSAKSSRNIDITLAWLMKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE24</accession>
    <name>A0A2S5BE24_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1977</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE24"/>
    <dbReference type="STRING" id="741276.A0A2S5BE24"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="283" mass="30127" checksum="71DC4E7F4862489F" modified="2018-07-18" version="1">MAKKAANKAKQVEGATPVESTADAPQSDNAIPKLPREPVLRVNPANLTELKNAVDDHLKVVLSSPQHAFVRSYMHDDVRLALGWTAVGVAAVTGYYSYVVDDFHRTKGWVAVGVAVYFALNTALALYVALVEKNTIYQGKRRTLASRITTERVSLSSVAYSSPTHHTTSSWVPFPLSLLLRAPPPPPATGSTSTASSPSAPLNTDPSHYPLYRLTLSYSHSANANKSLLASSTVVLEKPFGEMFDENGTIAVQVVEDWVMGSQGLGKVVKGGQGAGAIDGVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE57</accession>
    <name>A0A2S5BE57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE57"/>
    <dbReference type="OrthoDB" id="543507at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="417" mass="44466" checksum="55A62163E047F138" modified="2018-07-18" version="1">MAPSLPPRSTTLTRSSTIPYSKLHAAARRKARARRSVSEPPILAPEEEADTASRVASPPPAVVATSPKLEPVQPIVPQDEPRLPKTEPEPEVLPPSSSEAVEPTASTSSAVLSPPRLPPSHWASERFFGFSNYASYASANKVNSATPGFNLRATAAALAPSSSSSSSLACSVSSSPWSTDSSSSSSSVSPPSTSTSSSGFADFAASRASLSDLPPVDTPDAGPRTGPKYSSKVEGKKRAYEPEPGAAEGIPQDSSRPAKTFRDRKSEAFAVASPVIPPSTFAPGAYSRRVAGAELTASLSRKIDEQARQISGLKKQLSKETAEVEALRQELADEQERVKRRDAEVERLKAYIKKAKRFAHKMLYDDAGAFAFEDSGFASESDSDDPDYVDGLVAEYDYDFDDSGDELEDTGRFVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEK1</accession>
    <name>A0A2S5BEK1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEK1"/>
    <dbReference type="STRING" id="741276.A0A2S5BEK1"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000464">
        <property type="entry name" value="Ribosome assembly protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="6">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="240"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="287"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="412"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="496"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="527" mass="57697" checksum="B12A4904C7579F12" modified="2018-07-18" version="1">MSTQIPPAPKRQRTTAPAAIAAKEAAAGPVQTVICQFRNAQDGTLLGPAVSLPADTGREGLELLVNNLRGTEDDPVPFSFHLQLPSSEAPPKSEDGKPVAPEEGLRLPIARSIHADLLTNPRHANKVSTEDVFMIDCEPEAVFRVREITRCSSSLDGHASPILCASFSPTGKYLATGSGDNTCRLWNLDSETPAATLAGHSGWLLCVEWDGLERQVATGSMDNSVRLWDPKTGKQVGEPMRGHSKWITSLAWEPIHLNASSPRVASSSKDGTVRVWNSKLRKLEFNLGGHTASVNAVRWGGEGVIYTASSDRTVKLWDGKEGKLIRTLSEHAHWVNTLALNTDFILRTGPFDQFAKMPKSDEEAKQLALKRYEAFTSRTPEQLISGSDDHTLFLWPPVNPPSANPKKPVARLTGHQKQVNHVAFSPDGRYIASAGFDNAVKLWDGRTGKFVASLRGHVAAVYRISWSADSRMLVSASKDSTLKLWDLKTFKIRVDLPGHADEVYCVDFVADKIASGGRDKKVKIWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BET7</accession>
    <name>A0A2S5BET7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1641</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BET7"/>
    <dbReference type="STRING" id="741276.A0A2S5BET7"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="77"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="515"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="553" mass="59914" checksum="51F834BE274CAB3B" modified="2018-07-18" version="1">MINITHTPEGNLLTYVNGEPVICTRISHMLPRLYSRALTIDFGRQTTSETVHRRTPRHRLRAHSPRRIGRRGRRVITATVIVHIMPIGLGLLYSGLMRRKNALSMLFLAMSAYAVGTLQWWLMGYSLTYSETGSTFIGTLRYGAGVGVDIQPSPGSTAIPALLYFIYQAQFQSITACVLVAGTAERGRMLPFLILAFAWCTVVYNPIARWVWSSKGWLYPHDLDFAGGGPVHIASGTGSVVLAFFVGPRRGYGTAKLDYRPQSPLLIALGTAFLWFGHAFSRFLRFWNCFNGASMSALNLKSMMCVSNTVLAGCAGALSWTTLDFIWTRKYSAIGISSGILAGLIGITPAVGYVGLPAAFAVGAITAVVANLSTSLKHYAKIDDAVDAGALHGMGGICGAIVTGIFADSRVASFDGMTEIEGGWINGNFKQMGWQLAGCLTIVTYTAVVTYILCFVINLIPGCKFRSSEEAEIVGIDEAEIGEFTFDYVLLDQDYQPRQRVPNDPKLAAAARLSTIREEEKSRAGPGTPSSVSEAELDKGDGVGVEITEVQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF72</accession>
    <name>A0A2S5BF72_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF72"/>
    <dbReference type="STRING" id="741276.A0A2S5BF72"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="418" mass="45070" checksum="11000016D7153370" modified="2018-07-18" version="1">MATAAPAYNVKDSPSLLACGRLQGQAVQVDPASIAPRAGGRIYRATLNGPNAFPHLCGGVFGSVAIKVTEDDRTRKPRDPRREALMLADLDHPNILALLNAYMSEPSAISPEPRIMLFTPYYPLTLRNLLDSPAFSPDISQPDFEAVATSIACQLSHAIAHLHERGIAHRDLNPHNVVLSSAGRVVLIDFGISVETGQEKPGEMHFEVGTGAYRAPELIFASRDYDPADLDLWALGCTLADLYRPLALPVPPSPPSSEGSFERYYRECATPEPEPKLSRRPLFDASSSDFVLAASIFRVLGTPTLETWPEATRMPNFAHFTFASFPATPLGSHLPYLQTPSPTATILPQLLQISATKRVKASAVVEAFRGSGEAILAPDDLSESERGLLDSSGGGAKMVDRLPDGRLLRELLAAMVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFA1</accession>
    <name>A0A2S5BFA1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFA1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFA1"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015411336" evidence="1">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="194" mass="18036" checksum="BD48EB3D27E1DF5F" modified="2018-07-18" version="1">MKFSLAAAAVALATAVSAQSLTINTPTTGLYTCEPAQLQWSDVIETLVAGQNVNSYTWNVNVAAGTSVTLGVTDSTGSSNYAQQVTITQGSSTSCIGQAASGSSGSAAATGSSSVGSAAASSAAVASTTMASMASSASASVSSAASRASSAGASAASAASSGAAAASQSAKSSAGKNAALSGLAGVAAVAAFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFE8</accession>
    <name>A0A2S5BFE8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFE8"/>
    <dbReference type="STRING" id="741276.A0A2S5BFE8"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="444"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="870"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="878"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="946"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1115" mass="116903" checksum="207D2C6DFF21229A" modified="2018-07-18" version="1">MSLADYGYQRQQQQQQQQHATSSGHSPSHPRLRTVSAQLRGSLSHDHSSAALGHASPAFDSHGWSDWNLHGISPERATAGHLYSDPYSDLIGGGPAEDHHYGHADTSFPPGQGYDTHMTNLMSIDDSPPRRNFGPTDHFHEHQEQQYPVLHHAATPDMAHAALLDRGALAHSQLAHSYPASLTGSPARSRASSLQSIAPANLDMSSLPSPTHPLGAASGLTSPFRVSDLYSSVSSTIHPSQALRRGSSPSDTSSVSGLNFSRLETASSSTTSSVFGGNDSTGPSTPYRSGSVSRSNSQRDPTQKHARRRSSPIKLTNRHQRKLSNAERKAICVFHLTHPGMKQDDIGAHFGYERSTISKTLKFKEKYLAMDSDDEADLCEEGSQSGSQSQNAQNALYASSPSPFDYGEQDHATPQPSPGLVPSSSSVSSLVSLNSSVSSDHAAPYVGKSHGRFPHIDSALLTWAREQAARGSSLSDSVLQRQARAIARASGDNKFKASATWLDGFKMRAGITAGQFCEGFGSKAAAAAAAQHALSFSSPPSSAMSSSTHLPRALSPPVEEENEDDDAGQTTLRAEEPEEEHANQQQEQQVATRRSKRNLGSKTVRCLANAKSTLGAFADGLIRSSSPAAPSPSGRPHGNDLQSSTSTIAGGSFGDLSMDSEATPTHSAAHSRDTTYGAETSLAQPYSYSPTAPVPPASATPSRGASRPESSYLPSHDGYSPTDASAQYLHAFEFPGSHGRTQAPHERAANFAGGGLSSSSSSASLAGFDNPGLGMSVPHGISPATSVQLHRRSGSTASTTSVYSGLTAFSSQNPGTPLTSSISGSYRDGQSNACSLPGTPANAQASYFASEQAQLQNSLLSTGRIVHSTPTSVYSPASSGSAQQQQTQTYHHQQQNSTSHTRYPQHSYPSMADSQGSSSQSQSLRRSTISGGLPFNASLRASTNSNASSAAMTPSLSLSSSSLRSPGHPVTLEQAFSSLEIALEYLSTRAGQDYVSPKDLVVLADLKGKMERARGSSPPSLDAVASAPATPSGLGPSSSNAMQIQQQLHSPFVALPGSGNVASLDRVAKQQRVRLSRTQSAGSVLTMGGMSAAPAAASAGVSTRRSGPRPAAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFL4</accession>
    <name>A0A2S5BFL4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFL4"/>
    <dbReference type="STRING" id="741276.A0A2S5BFL4"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="129" mass="13632" checksum="0F7B06ABD84F381D" modified="2018-07-18" version="1">MLPNRNKVDISSFSEQEKELFQKYGKVPPQKNLLANKLKERKYFDSGDYAMSKAGVSPPQSVGTAIPSPANIPHASPPSQSIPGAKASSPVGSPDDGSNVGVGMSPPKHSSFIGSPSKEPISQHKPHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFX6</accession>
    <name>A0A2S5BFX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFX6"/>
    <dbReference type="OrthoDB" id="2529262at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="181" mass="19909" checksum="910650738E718766" modified="2018-07-18" version="1">MARDWLDSDGESEDDGLVEKRFSNARLVRYYQIAFAETASATFQAVLLYCKTGYIAFAPLTSSFAAAADAGTMHEQEYRAYAVLHPGMPRPVSPKSVYRLAHLLQIPDLQKLALDHIASGLSIEGVAHELFSPVATAYDEVRRLVRDFIVKRFDEAAVGEIDGGSKTLTEVLQAASPAKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG63</accession>
    <name>A0A2S5BG63_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG63"/>
    <dbReference type="STRING" id="741276.A0A2S5BG63"/>
    <dbReference type="OrthoDB" id="2523671at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42803" checksum="752F848B2ABF853A" modified="2018-07-18" version="1">MAQTYEVTDSAKVNPNYGNWSTSLPKLKEALVRRGMSADATLRMFEDPRRDRLALEWSNATSAARFREGRITATMRGEIILDLDLDGQKYPPTPDGAFVTRGHLGYGDLEVKLSFSTSPTTSMATDSVKTVSAMLAASMREQVPHDVRFVFAGTDLTLWASEAFLSEHVPHFKTLLASEFAEGTLAAPASGFTNKPVPAPHRLFEDSDDETDELLQKSYADRVKERTKPVAPGKTITVAESAYTTYAAVLLWVLTHEIDFAPLKSTGLEARADFLKKALDSDAFLPAPASPKSVFRLAHLLELKDLQDQAVAEFMHQLTYNNAAEELFSDVSCAYPEIRDAALAFVSKTAQEVEKSEGWKQVMQRADQDGLPSGASHVALLLAKRLITGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG93</accession>
    <name>A0A2S5BG93_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_1093</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG93"/>
    <dbReference type="STRING" id="741276.A0A2S5BG93"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="293"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="609"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY75780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="944" mass="105167" checksum="7B9C20637F42D300" modified="2018-07-18" version="1">MASTTAADHADARLGTDVTPIHYDLTIRTDLKALTFTGTAEITVTVHEPIAHLTLHAASPLVLEAAVLGSSQLKTESARPAEHIRVDEKKERVQITFAGGEIQKGEHKVGLRWKATLDDSMLGYYKSSFPKKDGQGKAFYALTQFEPCQARRAFPAFDEPALKATYSISLISRTGTVSLANTDVESTKHLGAGGAFPRTELLGDQFFSTETEKEVVGKTVKTEGKTETVVNKEEQDDAEFKDDWEITRFTPTPKVSTYLVAYMESSFTSPLTGKTIPLRVYATWDHIKQGQLALDTTAKILPIYEEIFDIAYPLPKLDTLVASDFDAGAMENWGLITGRTSLYLWDPKKSGLQAKKGIVSTQSHEVAHQWFGNVVTMEWWDNLWLNESFATLMGEVIIPDRIEPSWRVHSAFITEHLARALSLDSLRSSHPIEMPCPDEETIQQIFDALTYSKGASCLKMLSNFVGEEKFLKGVSIYLKKHLYGNARTQDLMAGISEASGQDVGKMMDNWLSKTGFPLITVEETGKGIKVRQNRFFATADAAPEEDKTLWHVPLQLLVVDSKTGKSKVHSELVLSERETTIDIEDVANTTYKLNAETCGVCMSSPSSVGSHRTLYPTSRLSKLGAEAGKGNASAFSLNDRMGLVQDATVVASSGYAKTSGSLELLAQMKGEEENLVWQEIATGLGSIVSTWWEQPEDVREAISKFRRELFKPVAQRLGYDFKETDDADTTELRTTAISVLAAAGDEETLAEYRRRFSTFIEKNDDSEIPGDLKTSIYSQSVRFGGEKEYEKVLEVYQNPPTPAHKSSAIAALCSPEKPELVDRTITMLMTGDVKNQDMGSFVAYLGRNRAAKRKVWECFQENFDGIMLRFKGNFSIGNIVKYSFMTLTSEKDAQQIEEFFKDKDTSAFNQPLSQGLDAVRAKAKWLERDAKDVEQWLREHKYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGB2</accession>
    <name>A0A2S5BGB2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1118</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGB2"/>
    <dbReference type="STRING" id="741276.A0A2S5BGB2"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="90" mass="10098" checksum="C5640ECAF92A82C8" modified="2018-07-18" version="1">MPTGSKYMGWWGDMGGPAQKGINQYVVSPFRQQPMRGAFAHWAKAGYRRLAQQAVYFAVPFGLGYAVIQWAIKDNHLRNSKHGQAQGLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGG5</accession>
    <name>A0A2S5BGG5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THO complex subunit 1 transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGG5"/>
    <dbReference type="STRING" id="741276.A0A2S5BGG5"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="83708" checksum="31214720C3EE9675" modified="2018-07-18" version="1">MVQTFLNYRQLAVEALRNLAASFSSRRQQDDSFSSDQVKHATEETLVGLGAPKVADAGVTTDGEEQDERWKVDAMQNALTRSFEVLVDEAASDDRANAERLNDILDVVLSSAELGYVDDTLPLTLLTNVLELRPVSECEPVLAYIESRIKRLTKGMEYQRGRGPILLRLLNDLLRRLPRSQSHSVILSGRILTLLSWVYPLNEKSGVNLRGNFNVGKGFSFEEPEKQGESEGDGTTAKEGPGAKMEVEEGEEAEESKQGAEDPAAFYSTFWSLQRLFINPELLSKPATAASTSTSSSSSIPALRDSVRKTLTAFSAATKKAKDLTGSTKEVGAAASARQAAKAKKEGDDEMDTTDLALEEYFFPKFLTSPDLLELELADPSFRRQILVQVLILFHYLLGFTPAERLRVEKLPHTNVSAFSTYVLSSENETWIRELRSRILDELDAMEGGRRFRKAVQLVLQRDQNWIDWKLRGCPSFILDPLDAAAQSETARNKLRAVMRKPKRFPYRLGNANLSRTWEKNLTSLDGFQPDVDDDELDFILREYRLEKNRLKQTEAQLARAAPGSAQRSQLENTLESKRTRLQALHWRAIRSASTQHLRFFSQIGAGDLEKLEQLIDEDARRREEAAEAEEANGTPVQQTTGYDSDSSVLEMTPKSKLPEPEPEKDEAEAAPKQEEENKSGEEAGTPPPPPTAATGEKNTEPVVVEDDDEPGTPPPKAVVASPGTPKRPREEEEEDAAMTEGETAAKRLKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGV4</accession>
    <name>A0A2S5BGV4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGV4"/>
    <dbReference type="STRING" id="741276.A0A2S5BGV4"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="354" mass="38681" checksum="8FE05549A9226AB6" modified="2018-07-18" version="1">MSDAEAAPVSSEASTSAAAPAFKRRKRPQAVRTSLLHRETTGDSSDPSTREQTPLSGFEGDADDSTSETLEELLALRRLKRSTAGLELDRLNSGERKKRPKPTPGADAAEGGVVALSNGMLEGTNGGLRAGAGADRIRDDSEGPEAKARKIIKTDGFTGQTNTVDVDKHMLAYIEAELAKKRGAGSDAEEAAAASKPHDPRDELYRVAEKYKFADIEEAEKGKKERDEEEGNVTLSASMLMGIPEVDLGIDTKLKNIEATEKAKRSLQDSRNARREDGDEFAVDRFYRHRRVLESDSDALSRARAEAAAAADPAKSDPDAELRKQKPRDGRRQLATDEMAMSRFKKRQQQQWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGW3</accession>
    <name>A0A2S5BGW3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGW3"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="34"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="194" mass="21492" checksum="D27D45A5C283DD63" modified="2018-07-18" version="1">MTARIDELTVLICPTCTCNRTRFYVCPLAQNVDSLGTVLGSTVWHSFIGGPIAYTSLPRQQFGHLQSRIFPRFFALQSLSALALLGLYSRRPGGGELVRTFWRHGNKTVWALVVMATTGLANWLVVGPITTDVMKTRHRRERIEGKSYNEKDVSPEMKALNKRFGKLHGISSLVNLVYLAAAAGHAAWIAEYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHE8</accession>
    <name>A0A2S5BHE8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHE8"/>
    <dbReference type="STRING" id="741276.A0A2S5BHE8"/>
    <dbReference type="OrthoDB" id="3199367at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="259" mass="27149" checksum="D30E6E21A5AAF2E5" modified="2018-07-18" version="1">MRVRFARKSLYLRKHALLLPAAEAGPEQKPPLFCFPLYCSSPHSARSLAPSVCLASPPTSMLSHFGTILSCALAFVAGTSVASAATGSDGVFDGGNGAVSKIDYHPPFLFPQGGEIWKAGQSYSASWEQSLPEGIPQQNVSQTADLMLGYSSGVEGDISQHLKWTLAHNVSLYAPAPNSIDFELPADLVSRDSYFLVLLGSSGNTSPTFSIVGHASLPTGSDTASAPAATAKASDGASPVAANVRRIVRKVRTAAEQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHM6</accession>
    <name>A0A2S5BHM6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-arabinokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHM6"/>
    <dbReference type="STRING" id="741276.A0A2S5BHM6"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053205">
        <property type="entry name" value="GHMP_kinase_L-arabinokinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38134:SF2">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38134">
        <property type="entry name" value="SLR1395 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="54465" checksum="268BF60F0264E455" modified="2018-07-18" version="1">MRFAFYVSGHGFGHATRVSAVSLELLQAGHDVTVVTNAPEIPFASILEPDLLPATARDVANPGPALAELPKYAQYRKKMVDAGMVQPKAYDVDRRATCDVLTTFLRQRDQSLKEEVVWLHEERIDAVLSDSTFLGWCAAANPALLPLSGLLTAAASAADIPSIIISNYLSHPALPPILGAEAPEPPIDPTELDPLVQQTIADYSCASLLLRLPGVIPIPAFDNDVPLPAGRWINEERTAFVPEIEALLSRPTKSIPSAAAGRPVIDVPLIVRAPSPEVNSTEFRNAILTGMGVPDFLLDSKVLLVSFGGQAIPRPKTRPPSRLSSPLRRSSSYNGTNGATSLAVPSDELREAGLLPKGWIAIVTGLSGGENAIRDDLPYGFFASEKDVYVPDLTWIADCVLGKLGYGTCSETLSCRTPFIFVPRPLFVEEFGLKRLMQARGTSLELDRADFEAGRWEFHIEEAYELGRAAKEEARRTGFVDEGAGQVIREEIEKFMEARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHS5</accession>
    <name>A0A2S5BHS5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHS5"/>
    <dbReference type="STRING" id="741276.A0A2S5BHS5"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="318"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="714" mass="77784" checksum="D125CC0B91CEE605" modified="2018-07-18" version="1">MDRRKPYAKSVVQAMQLRIDTLEAQLADLTGAVPLRDPTSPRQRPPAAMSASSRSLASTSPDLHEQTKPLLWSHLGGSPYADVGSSTSRPGTANGQFLTLRPSTANADSHDIDMDRFRGGLALNAHGELRYYGPTSSYRAVLVPPADVLVDATPNSPQLAGPAATLQALRSYSLTRAPIPTAAPCEPVFPTRPPELSPDFKARLFRLAFEFGLAHYNVVPERQFYQDLQMFPLERTEFCSPFLMHTVLAVGSRYLERGEDYPPEICGLYGDPDTRGDVFVNWARFLLDQEWYNPNMSTIRGLLVLGMYMAGRGFDGPCQIFVGLALKLSEDFGLNLGPHRLAKVPGSSLPRELFLTRGDCFWSAFASDCISSIYIGRRTAFTPEVLDVEIPPIVAELDYDEPQYRSSAFSWSSRLMVIACRVLAEVYSPSAHKTADQRRALVPALHLELESWNHDLPSFLRANGNAKETSKAPHPHILALNMTYHSVHIALHRPFYHARSDGSNDKDKSEDLSTEKCLLAAANIVRLVRLLKGSAGLARSAPGVQLAAFSAGTVLALAAFPPMTDRASGPPKRDSARRTQAKKDLYFLVSALKEIGPTWTTALTSAGVLEAIIATYESKEEEEEARSASGAPDPPLQPPPHVHTFMPTPPVDSSATLSLVAGPPASYPFPPPAAAFQSLLNPPTAFAAADLSPLSYGLGIQDDTADRLGGMKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHU6</accession>
    <name>A0A2S5BHU6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHU6"/>
    <dbReference type="STRING" id="741276.A0A2S5BHU6"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="295"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="570" mass="63095" checksum="8F766AEE14707940" modified="2018-07-18" version="1">MGKEEQLPISAAPLSSSDAQTPASPKTSYRHRLAALALLLPLAFWLSFPRGGSLAPSAGCPHDRASKVPACPVQPSPRSVGEDWDPVKDEDYRKLAIERFSGAIKVPTESYDDFGTPDDDPRIDKFAAFHQYLESTFPRVFSTLQVEKVQKYGLLLTWKAEQHGLEKRLKPVVLMAHQDVVPVNPGTVDEWTHPPFSGEIDEEGYVWGRGTADCKNTLIGILAALDKLIEEGFKPERDVIFSSGFDEEIGGSRSAKYLAEAIEHRYGRNGVAFVLDEGFGGITPIYGQTFALFATAEKGAVNLKLDVATPGGHASMPAEHTSIGVLAELISTLEKHADHPKLRPSSPKLAELQCYAEYGNVEKEWKKRLRNPKQWPKLARELSRDVTSRSTLMTTQAVDLISGGVKINALPESATASINYRIEFSSSVDETTDRIRSILEPAVHKLNLTFDAYGSHSDAKQNVVRLSVIEGSEIEPAPQTPTKGTVWELIAGTTRHIWHDAIATPTGMMANTDTKYSWNLTEHIYRFVPGRIDQIKGFHTVNERTHIDAHLTGIRFFYKLIRNTEGWEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHZ1</accession>
    <name>A0A2S5BHZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHZ1"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="273" mass="31759" checksum="975A99050EBF208B" modified="2018-07-18" version="1">MREARASERPPRELVSRFMGDRHDRRSVEGILDRFPALCKRNFFLDNELISWAIPRKFFGDGQIRLAAETVPHYFSEGIAEGVQSGRSYDALWDVGTYEVDTTEVRGGLIASETSEDSDPESFVPRDVTEEDKLRIGYHRCRWLNVPASPTSAGIPEYGSTRGMRKFRIILYGQRFHGLRLTFTRHIGDGKIVRSNDLRLPDYKILWMLWVPEAKSEQNKRALLEDTSILTGRTLETIRQDGIKWRERFLESYKRLERAPLRLWARESVQQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI05</accession>
    <name>A0A2S5BI05_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic phosphate (Pi) transporter, also low-affinity manganese transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI05"/>
    <dbReference type="STRING" id="741276.A0A2S5BI05"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="676" mass="76421" checksum="68E544A76E06F56C" modified="2018-07-18" version="1">MQHNDVYADGPHEIDTHQEKEAFAPTPSGSNSSMTQSNATGVDASLLNASLYPDDSYTPDGTYWADLPRGQRTKFVNKQFNEESAREARYIWDMFKRDPAAPFKAYFRKYVLTGMGLFVEGYVLFSIGNLKSIFASTWPQCWGNKPTVCDANWINAINYTQVCGIIIGQALVGVEGDWIGRKFGLCQDALIMLIGSILLTGVWSNNLNIWIIVYAWVLFVYGVGVGGEYPMTGTRAMETTAFGLEGTRDDRLHRGRNVVGSFLMQGWGQIFNQAILLICLLIFSGGQEKGRYSAKATQATYRVQFGFAVIVHFWLLYHRIFKIKDADTLVAGVKRRQNVSGYDAHSFRLLMSHFWGRLFATAGGWFANDVFFYGTKVFSGLFIKILIPGASTIVTWEWNMLNLACSLVGYYMAFIFIDHKGYGRRNMQMVGFTFDFLIYLFAGIFFHQLQKPGAPVKAFTFMYNFSSFWNQFGPNCVSFLVAAEVFPASVRGTAHGFSAAWGKAGAVIATAAFGYIDNRSKYWFAVPFGALGMFCTYFFLPDTTGLDLREQERYWRCVRAGRAEDYHGVAIHPHHLSWYERVILKRQKHYDPVQDRLDRIEELRVLYEASLIEDAYMNPEAAALDEGVVRYFRSEAPRAVAVDKQAAKMRALAENQPETEKRGVPRPSKLEDTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI15</accession>
    <name>A0A2S5BI15_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI15"/>
    <dbReference type="STRING" id="741276.A0A2S5BI15"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="51516" checksum="1F02E1B45683D032" modified="2018-07-18" version="1">MPNSNNPVGVVIIARHGDRTAYYQNPETYDSTDTVLTALGEQQNYQMGQMMRRIYAGADPSRAIAGLSNTTFVDSAISSMADAGGEGSVIYDSALAFWQGFYPPNPSASDIALANGSQIVSPLNGYQYVKVETVLPADDIDFEPWTNCAVWTNQTSGAYASPQFTAKAAEAQGILDTIKNSGIVGDRSVTLKNIYNVWDYMNVNSIHNATFAAKLNETSPTLLAQAHDLANFHEYSLFSASSADGLGNLPGRALFPRLISHLQAFTESGNKLYISHLHMSYKPFISIMNMTNIAASTDPVFEYPYAMVDYASSMTLELRHGGSGSSGYDVRLGFRNSSSADGDLTYYPLFGTNDVDMDLDTFVSKLQPALVQNNTDWCSYCQNNGSVATCSEWALAQKYETLAASYKHQSDSHFTSVGSGFIGACVTLVVGAVVLAALRGLGWVSFGKRAGGRRGESDRYPLTDRESFKGSVASHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI17</accession>
    <name>A0A2S5BI17_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI17"/>
    <dbReference type="STRING" id="741276.A0A2S5BI17"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="754"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="761"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="813" mass="87616" checksum="AA16CEB718A37EEF" modified="2018-07-18" version="1">MPAFSFAQPGPSSSNSGENPFARQPAPADSTATHDAPASKSRTAAPKLRESRAFVIEAYTIWASLQRIVAEYEAKTIAQYGAQGSGAVPPPEQVQYYGRVCSLYRDAIIKQLPLINNNADLTAPQKQKSLAHHAAMHALLALVEILYFPRDGRGEGLVAEELLDWVNTTDRAPSAEEGTELVALASPWDSPAFFPYLHRCLLRGHLASAAALLNLVVAQHPAPYLQTVARLVAELVASFPRSTNYRTESAFATALRAWRNSTLPQTRSEIDRALSEAESDPVLGGPDNEDERASFEQGFTVVLDLLTGSEQALLDSAADWREALSAFGIWSAPGSLRRADLPAIVDRITSDAHPVDTSLPTEVAQLALFKGDVAGVLKTLTGPWAWLGTHIADLLSHLHLPMFDLPPPPPTTTATTGGGAQQDDEVDSLGLREHFLLDWGQRCVGADPGLWRIACEYWTACGRPGKEKARELIKRLEIVAPGEQERDEREKRKRAEPESRTDGMDVEGAEAAAAPRKDADAEAAALLATLGGAGRRVDELLIVCASLDLEAEFIDICSRYADWLVERKRYGEAVAYAVRAGDGTKVATIAELIGEEYVVSGQEAFVKHVDSLPTSLLRPNDPASAEASSGAELPSLSELPSLTSDALRPHLSRLAFLARYRDFLALYAAGARRGAAELLVLLLTSGVAPKKWWAVMLLDAVPLLETAPPLVSLAETFELLRILEELLTPIVVSSSPRDIFGSLKLLGRLAESAGTESTSQGAPPAAAKAKKVGASAVEGEKEKEGERLRRAMSQMEVVRTALARHLATCSCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI60</accession>
    <name>A0A2S5BI60_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI60"/>
    <dbReference type="STRING" id="741276.A0A2S5BI60"/>
    <dbReference type="OrthoDB" id="2529615at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015728058" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="54302" checksum="23A06411A9A893D8" modified="2018-07-18" version="1">MRAVRAAAWLAIASAASSTASSAPPRLFDCTAVDSPDTALQTEWSCVGAGGPRTIVRRRSHEPNGATRNLRKRQTQASDGIAETSAATSAATTAAVAETTTAPAVATTTSPAVTTTSQAPAVTTTSVPEQTSSAAAPITTTSQAAQTTTTAQQATTTSPSAQQPTTTTAEQQQTTTTQGTQPTTSSSTINSATSGTRTADSSAASPSNASRSQSSAVAAASSASSLSAAVSSASAAGSSVSLVTHTYTSTFTNADGSIGTSTGTLTSASVVPVQNNSSGNTAKTWGIVGGVVGGVVVISAIVFLVYRLTQRRFSNLDDGDIDEIKWPDLLPDGQDVSATTTTLMPLSTHRTNGAGVGDDGMTEYGGEGGGSGAGRSMSGVYAPVSDGRRQSTATLLSQQGYHDPYANGTSFADYSRQASYEQLAMADGGAHAFSHGYDPFAGAAGGGAIPQQGTVYPPSPPQHQTAQFGGVWPASAAPRGAPGAAGAMRVASPPPQSRTMSPPPSHPAGGSLGKLPSIRRAESPFAVPGIAIDDEEGGGGRGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI84</accession>
    <name>A0A2S5BI84_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI84"/>
    <dbReference type="STRING" id="741276.A0A2S5BI84"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF52">
        <property type="entry name" value="MITOCHONDRIAL CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="65152" checksum="F79A5146D3EFAC18" modified="2018-07-18" version="1">MSSASVPVAAPKHDDDDRALVLPGTAAPAAPPADASSAGSNGASVSAALSRAFAGMLAFMFKRPIRLFRPVKISTMAGIQAIAEERGRSVTPAFVRGLIRNEGWRFFPRHILPPLTINAVIGLTLFTTYTTSERLLRNHVDSPLSTFVVIPFVSGASAGAAQSIISAPLDNARHLLLRRQRFLRQASELPRVSRRHRIRLAASNAAGLPFTSWWSLLRDSVFRSGAIVPTAPTSLPIPAPKLSGRERLERARRWARRGWSFFSLSVAKDSVAFGVFFVVFEVGREAARRVGLAYDGIDVSALSTFDEKEGANRQSEKQRRSASGLILQSVLILVSGGLAGYIFSVVARPFERVRAAIYEGRARWAEQQQQQQGSKSARPSPLNDKQPEKTRRARSAGGASERRSAAELGKTGRKAFAVRIGHIRSVSRSLLKTRRRKRGDAAIGEKPSANWHSTLNSREPRQIAKPSGAGDSPRPSRPPGPTPPSPAVPDAMPTATALVRRACRVYGPATFLFAPRSTLQAIDAGRHRAPILSSASTKLTPPPKRPISGPTRLSARARQAVSSQSAASSRLLRVGGTILRYVPPYAIGFFAYAMVSGDLKIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BID1</accession>
    <name>A0A2S5BID1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase CBK1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_0356</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BID1"/>
    <dbReference type="STRING" id="741276.A0A2S5BID1"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000828">
        <property type="entry name" value="Serine/threonine-protein kinase CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="168"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="486"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY76515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="559" mass="63762" checksum="5E5F22C33F9FC99D" modified="2018-07-18" version="1">MAYQQPPPPPQQPQPQGQGQGQAYGRGQVPSFIASNQQAYALQQQQHQQRLAYEQEQLAHDKRQRDLALFGSKPVQPPTDYVYFDRKPHFRKDTLEKAQAAKLKLEHYYQKAVQEAIERNTRRTELEKQLTTDHTIPDDRKARQLAQLGRTESSFLRLRRTRLGLDDFRTVKVIGKGAFGEVRLVQKVDTGKIYAMKSLKKAEMFKKDQLAHVRSERDVLAESNSPWVVQLYYSFQDANNLYLLMEFLPGGDLMTMLIKYDTFSEDVTRFYMAECVLAIETVHKLGFIHRDIKPDNILIDKDGHVKLSDFGLSTGFHKQHDSAYYQRLLDGEAASNGNGNATATPRQGPVGARNSVALNSINLTVSSKDAIATWKANRRKLAYSTVGTPDYIAPEIFLQQGYGQECDWWSLGAIMFECLVGYPPFCSENAHDTYRKIIDWKNQLYFPDDVKLSWEAEDMIRRMVTSADQRLGRNSADEIKAHPFFAGVDWTTIRNIESPFIPQLRSLTDTSYFPTEDLNDVPEQPTGADASAAGVDNRQLAFLGFTFRRYEGAPNHNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIL8</accession>
    <name>A0A2S5BIL8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIL8"/>
    <dbReference type="STRING" id="741276.A0A2S5BIL8"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="58789" checksum="E38A3AA54FFE64F0" modified="2018-07-18" version="1">MGQSQGRTTTATASQTNPLPPASESSSTPDARRGPERRKVLIIGAGSSGLVAIQEALAAGLEPVCFELRSGVGGAWRYDPDPGPCEWRFGDDGAAEPFTPGERDDRGKPTPTSMYASLRTNVPTPLMRFQEQAHPGSVNLFCTHNEVRQYLEDFAEPFLPYIRFDTRVVSVRHTLDTDPKDKSLNSVREEAPNRRWTASYRSTLDDDAPLDEQQFDAVFVASGHYYRPHVPATVGLKTFTGELLHSRWYRDAKRFEDKTVLVVGNWASGYDITRELAASVHARRQAGHPAEALPRVYQSARSPSILGTWEPPNAPEYAQEVQTFPAIQRVVGGTVEFVDGRTVSDVDAIIFATGFYFSYPFLSPASSPFSTHPVTYSSPKSPSAAPDHAPQPSAKGLRVHNLDDRMLFYLPDPTLAFLGVPFLIIPFPFAQIQARLAARHFASSPRLPAPLTFRSNPSTAGPAGEEDGAPETRHSLMVAYPKDFDLHDRMLQEAGDLHEDGSARDKQAWRLTSAVNRDLRVGTKDLRRAVLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIU4</accession>
    <name>A0A2S5BIU4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIU4"/>
    <dbReference type="STRING" id="741276.A0A2S5BIU4"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF24">
        <property type="entry name" value="MIP AQUAPORIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="766"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="766"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="88413" checksum="277F706A4731A1A1" modified="2018-07-18" version="1">MSGTSEPASPPATADTSDSPRGRRARAKRQPANEQPPWPAAFAPDTSGHPPQHRRQSSAASNMSRKSAGAPLGDDAAQAAPSKQRPRHGSQRQNSTASATPSASSSATDSTAARRAVDRYQRPRPANLAGPSFHPEQRPSLAQTCPDCHTSYRSQNAGDWSDVEGSTALSGDESVDGSVGSRSIASAMAGKKPLWAIGGVFPKKRRQRRSTATSEEPGPIRRRSTLQPPEARKASISGGSVPGHRLSLRPSRQSSQPPSSSSRPPRTFIEPIAGGETPGSQVIESDLETDRDWTAAERPDPFEEVRQTQSRPRPLDVVVSNDSGRSREGDATQGSSKRDSTAPPDGREKPDDLEKVPSHGSSPTIFGEGPPDAGEKEQGAAEPDADDLQYERDAEDGHKAGNTGQALGGKLDQRADEWEDDTGDDLPIRNRWGTIRYALREPMAEFLGTLVLIVLGVGSTCQTKLSNETMGAYQSENWAWGFGVMSALGGHTNPAVTITLALFRGFPWKMVPRYIIAQILGAFCGALILYGNYSRAMLDYDPNKLYSAGPGSNISATLFVTAPASTIGTPVQGFCQEILASGILTIAVLALGDENNAPPGAGLGAIVLGFVVVAIGMSNGWVSGYAINPARDLGPRLALTCFGYGSILWTGYWWWWLLGPVAGTLVGSIAGALTYDLLIFTGPGSPVNYSSRELWLASGIPTVHNMVWIALSPNKRQSRRFINGAHAAEAGLAAEVAMRIEEQRPGRANSQQLNEAALIERFRKGRRRVAEQEEEQRRRREERERQIRESLEEQRRAPLPSSSQPDLRAHDEETEGQPVEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIY2</accession>
    <name>A0A2S5BIY2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIY2"/>
    <dbReference type="STRING" id="741276.A0A2S5BIY2"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="128"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="453" mass="48842" checksum="E439D1F34BA50DD8" modified="2018-07-18" version="1">MSRVLGSTSPTRRLRQLVQHFAPYSASAASPWFPTTRLDSASRRLLHRALSTSSPNRSAAQGTAAWTFTTSAAFHGKPTNRSRRSGPHHGDSADLLARPKSVQQGLAPDHPLCVWRDQHLAEGKAPKEIGAGHDWWFVEGIPSEDEPRGTRGVVLGVADGVGGWEDSGVDPSHFAQALMWFARERVRTASWSWPTDTGSRSGESLKELLDGAFKDVTNEEAIVAGSSTACLALLDAETGMFHAANLGDSGFFILRPHATDSLPPTPPASPVGDEKDATAPPPGPSTTYSVLHAQEPQVHFFNAPRQLSKIPAAELKRAGGEEGGNWLIDRPKDADTFSMQLEDGDVVMLFTDGYSDNVWPSGETDRLLELVRSRIGTTAAASPDSTMSRADADKELASSIAQTAVTFARMIAVRPDVYTPFAAESKRWQVKGMERGGKVDDVTVVVGVVRKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIY3</accession>
    <name>A0A2S5BIY3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIY3"/>
    <dbReference type="STRING" id="741276.A0A2S5BIY3"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="48"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="338" mass="37408" checksum="5D3DCE44860DB8A3" modified="2018-07-18" version="1">MSPALRLPASSTEEQWLYTREEIANSPSTRLGSMTVQEELYNRARAIKRLWILRTYQSVHQPVVSTAATFIHRFYMRESFKEYDPVIASVAAFFLACKVEEEPRSIKHLVQYLFELSKNSNARADRIGPPQSDAPKFQELRGKVLAYEEAMLRALCYDLTIRNPHWYAVSAAQQVWTAAETETGTRVAQAAWAFLNDALALPLCLIYRPQLLAGASILLACAQLDLALPPSPGSLAEQKALHEIAIQEAEEGEEPPPFVPKAGLLGLLEIRPEELREPSMAMLGGYTMARDPFVVDESNTLSNKVAAVLAELERGHSTLKAAKASNPPSTESAMAVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZF8</accession>
    <name>A0A2S5AZF8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_7058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZF8"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="240"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY69926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="451" mass="49786" checksum="9B4BBEEFFE68C6C0" modified="2018-07-18" version="1">MLSASRVLRTAAQSLKPALATSSPRPQTTPQPRRATAPSTPEQWQRVARHRPPPTAPVLPPTTSLRLPKPPFVRLQDPSVLRPAGARRPDPSVDAQTTASDLLKSGRKRESALATARDLAKNALADLLVDTYPSLSPEASRGAETLLLGDDSLSILSEHYKLARQPATAEVAAQSETGHTRSTADLFRLYVAGLSAQEGEAFARQWMRQCLRSVLNHGYVELREQQKQAARLARGKEILSPMSHLRNFLRHRPELKPVWTIEVKGEREEYRATVELLGLKTVGSAKSVRMAKQNAAEKLMDLIWRAAGPEDLDLSPRDYPKLLTLWAAQNGRVKPAFECQVEKAPVVRCTLIVEDKRFVERGLSKRAARFLAAQSAMAELAISAEDVRVEPLRRPSQVRRRERFQQLLAERKAALRAEPEGDSQPSGAASVEPGTPRPPSAELDRSSTVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZR2</accession>
    <name>A0A2S5AZR2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000154">
        <property type="protein sequence ID" value="POY70020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZR2"/>
    <dbReference type="STRING" id="741276.A0A2S5AZR2"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="184" mass="19851" checksum="86109B24524AEBE2" modified="2018-07-18" version="1" fragment="single">MSANSRERDAIFAALRAQKGNKSCVDCRAKNPTWASVTYGVYICLDCSSNHRNAGVHVTFVRSTNLDIWHWPQLRAMKCGGNQPFLDFLARHPSAGSGQSASVKEKYSSRAAQLYKEELTRKMQEDERLYGKDRVVVEGAAVPSDDATAAATSAGGGGGDFFDTWDSPPSSTASPATSTTPAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B053</accession>
    <name>A0A2S5B053_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B053"/>
    <dbReference type="STRING" id="741276.A0A2S5B053"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="25"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="619"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="706" mass="77429" checksum="F67221B22865F486" modified="2018-07-18" version="1">MDTQLIKTVNLLQDAFAQSGLSTSTIDLPQIAVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLVLQLINRPATAKPNGTDGGDAKEEDGSKPTSDKLSNPDEWAEFLHRPGEKFFDFNKVRDEIVADTELKTGRNAGISPVPIGLRIFSPNVLTLTLVDLPGLTKVPVGDQPRDIEIQIRNMLLKFISKPNSIILAVTAANTDLANSDGLKLAREVDPEGLRTIGVLTKVDLMDQGTDVVDILAGRIIPLRLGYVPVVNRSQRDIDQKRPIHSALESEKQFFENHASYRSKAAYCGTPYLTRRLNTILMHHIKATLPDIKQKISQNLTKYENELASLGGPNGGTDGSSVILGIITEFCGDFRTAIDGSSSDLALNELSGGARISFVFHELFSNGVKSLDPFDYVKDADIRTILYNSSGSSPALFVGTTAFEVIIKQQIKRIEEPALKCASLVYDELMRILAQLLNKNTTFKRYPGLRDKFYSSVQNFFRKSMTPTNKLVQDLVSMESTYINTGHPDFISGHKAMAIVSERMNQNKPPATAPGVDPKTGKLLPGTLNNGKDLDVDLKQKEEGFFGSFWPGGRKNPALAQKKGAAAMDAPPPALRATGTLSERETMETEVIKLLISSYFALSKRTLIDMVPKAIMLNLVFHAKDAMQRELLAELYKPDMIEEMLKESDSVVQRRKECIKMVAALNKAEGIVASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B095</accession>
    <name>A0A2S5B095_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B095"/>
    <dbReference type="STRING" id="741276.A0A2S5B095"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="62"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="412" mass="45516" checksum="02276D7D66DED358" modified="2018-07-18" version="1">MLSNAKELDSVIARLTRDPYRDLPRLVVMAATTDEPLIYSGRGGYAQLPAKPTDASELERLGEPASEDSVFELYSCTKLPAVIAGLQLVEQGKISVDDDASKYIPELKDVKVFKGFDDNDELNLEPISRPVTIHHLLTHTSGSLYTVFDPTMNRVGEKLAGKANVYGAGNSPQNLHEIPFVAQPGEKFCYGYSLDYLTSIVEKVSGLPLEQYFKENIFEPLGIDDLSFMANAKQMPMAFENSATPDGPYTIRANDPMSEKQHFGGAGLKGSPRSYLKIIRALLRGGESDGKRILRQETVDLMFKEQLASDEQRETFQRMAQLNFDPAIRKAGGKVDPATTHGYGGGLHAESPTGKALGTLSWSGMANTYWWVDRTNDLAAVVFTNVLPVGTQRVMEGWHEVEEKLYEGIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0B5</accession>
    <name>A0A2S5B0B5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_6802</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0B5"/>
    <dbReference type="STRING" id="741276.A0A2S5B0B5"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY70219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="464" mass="51256" checksum="7F744640E87641D4" modified="2018-07-18" version="1">MRYSRLSTSEEPPVPLDPTAESTPGVSILRPLRGLDCNLFENLEASFRQDYRKFEIIFSVADEADSAIPIVKELCARYPNVPSKLIIGQEIVGVNPKINNLIRAYRAASYDLIWVLDSNVLTSETCLSRSVPLIEPASSSSSSALNGSSARPIGLVHHLPFAIYPDTLVGSRVEQVYLCSTHAKMYLAINRVAVASCVTGKSCLYRKSDLARASALKRERGKLPLPPPGLAGTDEAGLAAFGQYLGEDNEIGVAIWEELGMRHAMGVEVAGNAVGSMTFTKYFRRRVRWIRVRKYMVTASTLVEPLTECLLAGLLGSFAFRHLFSIPTWVFLPAQTFAWYYLDSALYKALLPASPARSTVTRPPAHDGPGFGYFQAWAVRELLALPIWLFAMMGDTVGWRDEGTVYRVQRDGSVRALREGEEEAWIERAWATVSTRYLGSRKGYVTIIPGDVEDGRAPAHADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0C2</accession>
    <name>A0A2S5B0C2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0C2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="76" mass="7883" checksum="F8C425F1405BF21C" modified="2018-07-18" version="1">MTRLPPMAIAPTVPAATHLNADGGETLLAGLVDPVRLNEQKGADAALDAADMTELARLERLETTDDGTLDAVSALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0H7</accession>
    <name>A0A2S5B0H7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000138">
        <property type="protein sequence ID" value="POY70276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0H7"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="384" mass="41243" checksum="09577F473558E95D" modified="2018-07-18" version="1">MPPSRTDSRSRKAVKHTLTDPEDSDDELRKKSRTMTKEFAGGKGKGKGKAKQGEGAESGLEEENSSGDGEAAAKVSAKGKGKAAAPVNPSTAKGGSKTKTKAATAPKKVTTARRQKKLPKEAGHLAGGGDVAPHGVLTGAAGHGGIFRITKAIKKALEERGVTAYNLYSKKPEYPIQHGDIVYAETYDLRKVESYYEGNSAAPEQWSSVMLMVPLSEADVAGFEKLYALYGSLEKISGYADLRKKDKSKVQEWAKKAASGAPIDFSHYAKVNDKEKSIQQSCTALWEHKHPDPKFNAELALASIRSKSWDRKNLKSKGDDVDHSLDSDTFIKSLLASSYDPETHPDGWYLEGLEAEYAEAEEGEEDAGIAAGSEAMGADDSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0I4</accession>
    <name>A0A2S5B0I4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0I4"/>
    <dbReference type="STRING" id="741276.A0A2S5B0I4"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="361" mass="39841" checksum="99C5AAE421F16E52" modified="2018-07-18" version="1">MGSARPDESVYLSQSNPYRPAILNLADSRAYLERIGLEADWATQQPSIDLLTKLSVAHHLSVPFDTSALHVPLDAWSKRDASRLGMRHGPGMQLGEPNFERIVSRRHGGFCYALNPLFASLLRGFGFRVSEVAARVYLHRGKDPQEAGYLWSCNTHVALIVDWRDSNARYLVDVGFGGGGPPYPIQLQDAATAPSLSTCESFMLREQQMPVDDTAAFPDPPMGWTLYRRVVPVGAAIPDHTAAESVPDSYWTPCIHFSLATMAPEDTLMGNLFNCTSENAAFTNVFVVSRLLPNGGRQTLCRGIPAVDASAPQDGTSYAKLYTKDSLKGEEYDIAWIPFDNRSIGRVLEENFGFSLELRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0T2</accession>
    <name>A0A2S5B0T2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0T2"/>
    <dbReference type="STRING" id="741276.A0A2S5B0T2"/>
    <dbReference type="OrthoDB" id="2535599at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="73"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="315" mass="33627" checksum="DC3A4D4EC912C1F5" modified="2018-07-18" version="1">MLRKSLLPHNRLRTLTRYPLAFTAPCSRHTTAAMPHQTKTTLGVPNRLRERLDRDEVGSSMSIKLCTSVEIVGLAKAAGYEAILIDMEHNAFSLSTTNQLSCAALAHNITSLVRVPANEPQWISRCLDGGATGVIVPHVSSVAEAKAAVRAARFPPLGMRSAVAPHPQLQYEHLPARTANELCNNGTLLIVMVENQAGLDCVDEMAAIDGIDLILIGTNDLTQELGIPGEYDHALISAAYSKVIAAARRNGKHAGVGGINSRMDLVAKFVDEGARFVMAGTDLPFLLGAARKRGDEMAALREKTAAAGVPQAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B177</accession>
    <name>A0A2S5B177_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B177"/>
    <dbReference type="STRING" id="741276.A0A2S5B177"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="503" mass="54157" checksum="A25CEA763A6EDE6E" modified="2018-07-18" version="1">MSTNSIASLSFPAGHCVSKAEFSVGLFINGEYSPSANRETIDVYGPATGKVIARVPAGQASDVDRAVDAAQAAYETVWGERCSGRERGRLLMKLADLFDEHADVLASIESMDNGKPFSMARAIDVPEAAACLRYYGGWADKDHGKVIEVDDSKLAFERHEPIGVVGQIIPWNFPLLMFAWKLGPALACGNTIVIKTAESTPLSACYATQLIAKVFPPGVINVVTGYGDPVGTAIASHMRILKVAFTGSTAIGRSIMAAAARSNLKPVTLELGGKSPNIIFDDADLDQAVSWAAFGIYFNAGQACSAGSRIFVQETIYDEFLERLTRTVKALKVAQPFDSDAFVGPATSKLQFDRISAHIQSGKDEGATVHLGGKRHGTEGYFIEPTVFIDVRPEMRIAREEIFGPVVVIQKFSDDDDIVAKANDTIYGLASAVFSRDISHAFNIAKRLHAGSVWINCYNQLNPQVPFGGYKQSGIGRELGQAAIANYTATKSIHVNLTQANPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1H0</accession>
    <name>A0A2S5B1H0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B1H0"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="475"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="655"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1229"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="95"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1129"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1164"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1185"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1365"/>
            <end position="1421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1421" mass="151790" checksum="611230DD81DDA342" modified="2018-07-18" version="1">MESTGLPLGAGASLEQATRLPADEEQQRPDAIDERDPTLTAPPPGETASVNAHQDEQTMESMLDDMTAGLGPEAADEDRPVASTSEGRDDGERATTTTTRPQGQHTPTRSTRTATAGSANRGRTAGAAGFSPLSSATSVPGGASPAAAAAAADPAAPNGAHSSPSPSSSPISARTASSSTSSSPADSPSSTSSPSRRVKVYRLKDDAWIDLGTGTCTGEFIQSVIAPDPKRRKMAVTSGTPDDEAELERVEEGAWLVVKREKTRKVAVAGDGSPVKKGKKGGDSAAANGDPRLDEPGSAEQDEDEDEDENGDDDEANVILRSRVQPYPHGVTPDDLAEEDEVHSVDDNGNLTIDAGGYQRQQDTLIVWTERSTGADAATGTATLVDAGGDQDEEKEMALSFATGSGCSEIWDFIKAARRYLAEQAALRSPSPVPSDDALSSPPPRPIFPGSSTASLANSLPEPTLGSIPAFDLALRNMSRSAVGRERAASVVVRTGVIEKLCKLQQDAEDLESLEDLHALCRVMQQILLLNDNAIFEHVLQDEIILGVVGILEYDPEFPTMRASYRQHLSSPTAFVPVVPPDLISASLLTKIHQTHRLHYLKDIVLARIIEDSTFSMLNSAIYFNEVDIVGEITQNRELMVEVFRILTGEKEASATSTAAQDKAAPTSPSKGKERSLALGPKRTIGPDLPDDLLAERQAKRARVGSSTPPVESSSLVPAAGPDAVMTATAATSESERKLHAMLFLQQLAQMAKNLGIPARTSFYRTMCERGLLSALEGALRFAVNLPPEEEDMANTIRTAALGVWIAVVDLDPADVRAFCLKQGKEQEARSEAEAEDPVAALEADIAEDGEGADLGPEAAEREAKKRRLKEERRTLLGLLICMFREEEDIGVKAQLTEALRILVDVTGDGSLQPGPRMRQEDPEAERFLQYFYDHCVLSLVQPLMDLPERSDSDPPLSLPASSIAILTHLCDLLCFFVSNHTFRSKYLILSTPVLAKSISRILRPKPRLTRHTHLRLAALRFLRACIARSDEFYNRFMIKHDLVRPVLETAAEERDKDNLIGSACLEFFENLRTTNVKALLNHIMERSGETARKLATKTDGHAPLKTFETLIARWEMNNEPPPPASLLADTSASSMTSPSTGATSSSMQRQPSQPGWTPRRELEEESYFNTSDDEDDATGKEPTATATSTGLLNSPSISMSRRKREPAPTGEQKYAWLDSAWNFPSSIVGYGEESDSDDEAEQAKGRASAADPLAGGFIRDEAATLTEPPETKPRVSLPTAEHNKGSDNVTIDRFRQDVTTPPGVLSPPEDVDAPPPSFLPALGSLKRKKEEDEDDDGELGLLAKKRAPSPAGGKATSPPSKGPTGASAASLGSKSSSLGSAAGTGTTKLGGFKIALGGLKSKLGQGKAAGDSGDAAKSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1H7</accession>
    <name>A0A2S5B1H7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1H7"/>
    <dbReference type="STRING" id="741276.A0A2S5B1H7"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="837"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="904" mass="96672" checksum="C33E81CD3EC9FD15" modified="2018-07-18" version="1">MSDGPPQHPVYPGAYNPWHASPAHVPPYMHPLAHYQLQHFYAAQGLPIPPFIGGPSPSSSASASTPAVPSPTRSNVEPSPNATQPDQMASNPASVDTPSVDAENASPGSFAGAASASPTSPLNASTSSAAGKLQTQLDPNGSAAQAPLPPLSDPRALLQRSLQGMYQLVTAGNFDARPSRQGPGPPPKSGAAAKAKCDQGQPACDRCGKMQLDCKYHVFNKRGRKRTRTPNQIMLENCYEDLDRALMLLSDRTLPVIAEHTLDAASPIDQKPRIPTASTSSAPGLRPPDAYRPQGARASSSSSTSPGEGTDEDDPTSRELKSVIESPLAVLAHISSLKVSESTEEESGKRFLPNRADGGPNGKDPGGAAGTAAEGYFATGDYFSSLRPFFFHLEPSLHTPRFLRDVSPFLTTTIAYIAASYLPGLHDRVERLHEHVLRLSDRVWSEGLKSLEIVQAYLLLIHWTPIESDWGDDRRWSWLGQSVRIATEIKLDKTINSLTYEFYRSVTPLGPGASDALNDSRAWTWKLLFVAEIALCGSTGRLASIHTLSLSTPGPELPAQPAPTDPNYHIAALVTLNRIYTKAIAHANSLAASEDGHEAKHRAGFEDAWRSDLRAWAAQWPDINPFIRLIAQHNTTILTSISLRFKGPVMPVLEECRRSAFETAKMAVNWPDDSLRWTTNLVIVNIAYAATLLLRITGAKSEPIDPETKFLCAIVAELLVRIGDARPPVRTLATLHGTRIRMLLQAEGPKASGSATPAVSGESMPTLSNIIPVHTPLPAFGMHTPYPSGALGPHGAALPHADFSLNQVAPTVFNLPMPDSHALWDLFSESAAAAAGPASAAQSPRPATSHGPLGAMTPSAAIGGGAGSGGEQPPWNGTGPRPDEWMYKSLDQDWLSSEPGAWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1J7</accession>
    <name>A0A2S5B1J7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pex19-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000107">
        <property type="protein sequence ID" value="POY70668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1J7"/>
    <dbReference type="STRING" id="741276.A0A2S5B1J7"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="41214" checksum="6BAF67BB40085CA5" modified="2018-07-18" version="1">MPPPAIHDDADDLDDLDDVLDSLTRPTASTSTAVNADPPSKTPPPPPPQTSTSFPDPDDDALPDPDDVDLDPDMARQLEQGMHALLTNLGGGAPGGGGGSAAPDLAGGLPGLDEQEFTKMMQEMLKGDFGGGGGAPTGAGGGDDELQKLMAALGISEDDLAGLTGASDSNGLSGPIPAATASKARSVDPPTAVPPLAAPANFQDAIAASMSKLRDSSTTADASRAASSSSFSAAQAGGGDSAGMAAMLAQLAGMPGGAGGLEGLDSDEGLQGMLDDMMKQLMSREMLYEPLKELADKYPAYLTAHAASLSTTDRDRYEKQRVIVSQIVAAFEESGADYDPATETKESVSPEEAERRAERTERVVELVAKMNECGAPPSEIMGEMPPGMELGPDGAPKVPECSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1M0</accession>
    <name>A0A2S5B1M0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000107">
        <property type="protein sequence ID" value="POY70673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1M0"/>
    <dbReference type="STRING" id="741276.A0A2S5B1M0"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="166"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="296"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="42448" checksum="D8180BBB3C6353B2" modified="2018-07-18" version="1">MSTATASTSNVTLEQSLAPSRTSPDSAAIRSTPASSPTSAAPLSTQRPRKRAKLDRDSLEYALTSGFAGGIAGCVAKTSVAPLDRVKILFQTRSPDYQKYAGTWTGVFRASKDIYAETGVRGLLQGHSATLIRIFPYAAIKFMAYDKIHGEMRGAKQMLMPTAEAETSGRRFLAGSLAGIITTGITYPLELIRVRLAFESHHSPSDRASLLRTIRQIYAVPPPVPSDLPSTASAGAATATATLQHRPRSSITHFYRGIWPTLVGIIPYAGTSFLIWGLLKQDLFPRFLALETRRNHRAGLDLLAGGIAGAIGQTTAYPIDIVRRRMQVGRTAPGAGFWDTAKGVYRQSGWRGFFIGLSIGYLKVVPMNAVSFATWVGMKRVLGLEETPTGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B210</accession>
    <name>A0A2S5B210_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B210"/>
    <dbReference type="STRING" id="741276.A0A2S5B210"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002709">
        <property type="entry name" value="Probable iron inhibited ABC transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="77"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="389"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="629" mass="69612" checksum="48257048D9D045F4" modified="2018-07-18" version="1">MVVSASKQKRLEAKAAKAGAKGDSVTSSSKKSSKASTPLTVSANGSTDDLNSMAKLRLAMDRSGNGVLTSDPHSRDIHIDSYSLSFHGRLLIENAAFSLNYGQRYGLLGENGSGKTTFLESMANRDVEIPEHIDIYLVRGEAEPSDMTALDYIVQSAKDKAARLEAQIEEMTIADVVDDLALEAKYEELEELDPSMFEAKAGAILTGLGFGPEMMRKATKDMSGGWRMRVSLAKALTIRPHLLLLDEPTNHLDLEAVVWLEAYLATYNHILVITSHSQDFMDSVCTNILDLTLEKKFLTYGGNYSTYVRTRTENETNQMKAYAKQQDEIKHIKDFIASAGTYANLVKQAKSKQKIIDKMEAAGFIKPIMKPKDLKFDFPEVKKLPPPIIAFSDVAFSYDGEIKNALYQDLSMGIDMDSRIAIVGQNGTGKSTLLNLITGQLQPIRGTINRHASVKLAKYSQHSADQLPYDKSPLEYFESKFKPKFPSADMQFWRAAIGRFGISGSHQTSPISQLSDGLRNRVVFAELAIERPDVLLLDEPTNHLDMESIDALAKAINQFTGGVVIVSHDFRLISQVAQQLWEVKDRKIVDLSKSEITIVQYKANLAKNSQAQIEKARLVSKQAGKMANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2H2</accession>
    <name>A0A2S5B2H2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000093">
        <property type="protein sequence ID" value="POY70956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2H2"/>
    <dbReference type="STRING" id="741276.A0A2S5B2H2"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="65"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="600"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="806" mass="86882" checksum="9DCFBC07074EC8B8" modified="2018-07-18" version="1">MLALRQRALAGRATPRRLTRSLATPTSYPPAPSKHYQSITPPYAHLLSQLEQVRSILNRPLSLAEKIVYSHLVNVEEGLAGGDPIRGEKHLKLRPDRVALQDASAQMAILQFSTCGRDRTAVPVSIHCDHLISAYEGAEADLKRSIMSNKEVFDFLESASKKYGIEFWGPGSGIIHQIVLENYSAPGLLMLGCDSHTPNAGGLGSIAIGVGGADAVDAMTATPWELKAPKLIGVELKGELSGWCSAKDVILEVVGRLSVRGGTGSIIEYYGEGVERMGATGLATIANMGAEMGATTSTFPYSDNMRRYLHATNRGPVADEADRAHAAGFLSPDKGCEYDQHITIDLTTLEPKLNGPFTPDLSTPLSQFGKLVQEKGWKDELSAALIGSCTNSSYEDMTRAASIARQAKAKGLSVKSEFMVTPGSELINATIERDGVKADLEAVGGQVLANACGPCIGQWERSEKKGEENAILTSFNRNFKARNDGNRLTMNFLASPDIVTAMAFSGKLSFDPRHDELIGADGKPFKFDPPTGEKLPASGFTAGNTSYLPEPVPEPVPSTPLAISPTSTRLELLQPFEPHFSPEAFADPNAKLEFDDLRCLLRIRGKCTTDEISAAGKWLKYKGHLSNLAENTLIGATNDETERVNSAIDFSTGEEGTIPEVAKAYKARGQPWMIVTDHNYGEGSAREHASLQPRFLNCKVILARSFARIHRTNLTKQGVLPLTFANDADYSLVSAGDVVSTSGLDALLRGDLDADVDVVVRKADGKEVTIKTTHGLSRDQVEWIREGSALNLIKRKAAEEKAAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2H9</accession>
    <name>A0A2S5B2H9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor IF2/IF5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY70992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2H9"/>
    <dbReference type="STRING" id="741276.A0A2S5B2H9"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="267"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="399" mass="43191" checksum="29CB4B04A58CBE90" modified="2018-07-18" version="1">MADIDPPVDDLFAGMKRKSKKGSKKAVNLDELDVDASAPAAPSNDATSISGSGAAAVDLAAAPTPADAGGSDGELDFSSLKRKSKKKSVRIDSDVEDAADLEAAKPKSRKSVDKLGNEVDDEPVDNQVSAEVTAVDASGLDEFADLKKKRKKSSKKAFDLDAFEKELAEAEAQQDGGDEQPKSILKKSTPAGSDDEGDVDEDDEVVEGEDPFGKEDHDDSRASKAEAAATAKAWLNEDRDYHYTELLGRFYSLLYQSHPSLSGGSHKKKYTIPPPQLFREGSKRSVFANIADICKRMHRQPEHVIQFLFAELGTNGSVDGAAQLVIKGRFQQKQIENVLRRYIVEYVTCKTCKSPDTTLTKDNRLFFMTCSSCGSTRSVAGIKTGFQATTRAARRAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2K4</accession>
    <name>A0A2S5B2K4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY70995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2K4"/>
    <dbReference type="STRING" id="741276.A0A2S5B2K4"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="546"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="780" mass="87708" checksum="A7B9CE93261C3C26" modified="2018-07-18" version="1">MGLLALGTPLPWSEAKQHADYVREHGIEQLLHIWHRLKDRTGDRLLWGDEIEYLVISYDDESKNARLSLRQTEILQDLQADADERRRTPSREESPVAAGAESVNGTAAKVLEDGQTPQKNNEACIPVFHPEYGRYMLESTPGAPYGATLDDLLLVEGNMRFRRKLAKSRMKSHEVPLTLTSFPRLGAPGIFTDPYYPPGGGVARSLFLPDEITNEHVRFPTLTANIRRRRGSKVAINMPIYFDENTPKPFVDPTIPRDRNLWPEDANAREGAALDNHIYMDAMGFGMGCCCLQITFQACSVGEARRMYDAFVPVGPIMLALSAAAPIFRGWLSDVDCRWDVIAGSVDDRTAEERGVKPLQHDRFVIPKSRYDSVDCYIADTPSNRPEYNDNDMPIDPKIRDHLVERGMDKLLATHFAHLFIRDPIVIFEETLCQDDEKSSDHFENIQSTNWQTVRFKPPPPGSPIGWRVEFRSMEVQLTDYENAAFSVFIVLLTRAIMSLGLNFYLPISKVDENMHRAHRRDAINTQKFYFRKNLFDPKPGHPCDPSLDALSALPEDVSPRQPRSPVANGFGSHSREPSHCESSCSSHRPSRVPSPVRSDSTPSGPVEDEYDLFTINEIVNGSPERNFPGLIGVVRIYLDGLEKEGKVSAEVRKGIERSLELIRRRADGSLITLATYMRRFVHSHPAYKHDSAVTQEINYDLIKALDEIERGERPAPELLPEGWREGYDNKDGRWSQCCGAEEAKLDQQSASASDPIVKGAAVIEDKGLCCGPMTLPTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B358</accession>
    <name>A0A2S5B358_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Initiator tRNA phosphoribosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B358"/>
    <dbReference type="STRING" id="741276.A0A2S5B358"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="410"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="53541" checksum="222E39FB57667880" modified="2018-07-18" version="1">MTDTAAPKLVFPSAVDNLQADRGQIRQQLRDTYNRLHSIADDADFVRHEVGAAYPDFPLVANQRAGAWYVKPTGESIHAYFKSTDGHAGQHDFNLRRANLILLPVIRERGGLIIVDSTRRGKRFPDALSKTVPIWCAVLTRARMLILPPSEDNSSVPLETWEKHAQLCTSPQAVGRSEHAQIEVRIDEWAQQLASSAYDLSALRALDRPLRPFFVSPSSTLSQNRASDFTDCYPVVCASASKLAAEADGLERAQGFTYVQGSGDDHEAWSKGLTPPVFWAHADEILSAPRDEIDEVISRILSSQASTSGTGAAETASSRRIRSTGVHLCFRASPGDLVSENDGLLVRVVTSAANPTPSETEAAEADGPLALSARPGKAGYNAFFAPRYLEPMLDRLQTPLRNGVSVTVAVLEEEKQGEANDLGVAVALILLSRLYSDEAGLLSPNDPPPSVTKDRIRTRLQWILEEFPTVNPSRSVLNRVNEFLISKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B391</accession>
    <name>A0A2S5B391_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B391"/>
    <dbReference type="STRING" id="741276.A0A2S5B391"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23684" checksum="C1BA2244CA66CB76" modified="2018-07-18" version="1">MALAPQFATHRIAGKATALHTLELYLDIVCPFSRKQLQGVRRDVLPFVEAHPDALQVIIRQVPQAWHSSSTLVHEASLGVTRALLDSGKAKSYTDAAPQWRDYFYKLIDEQEAFHDEPCAIETPNQTRERLADYAEAVGVDRSAFLEAVKVGKGNAGTSVTSDLKLQIKFHRSRGIHVTPTVALDGLVEPSISSSFSSDDWSKFLEAKVLQAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3I1</accession>
    <name>A0A2S5B3I1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3I1"/>
    <dbReference type="STRING" id="741276.A0A2S5B3I1"/>
    <dbReference type="OrthoDB" id="3357304at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="676" mass="73644" checksum="2B8A5BB85007E9B8" modified="2018-07-18" version="1">MALEQIVDVYATQGNSEAAAQISSFVSEMFQADPTPTASSAIASVSRAIESLAITNAQDTAQEMHDPLRAVLPSFTYSMPVQVVILSVTLTLLSVLLVHLLFTMRYHAPLSRLNYALQTTATGISLANTAAQLHVVMNEARDTGRIWPYMFDYIEVRVPRQEWGVPKSAAWLLLQAVNMLATHSTHIQFLTMLFPSNLEAGLILGLLGPLALASSALNFTTLSPHPAVNDLGDAIRDTCTSSLTLLYTMALFIWGLTINRSRAWRTEGGTSSFGILALALGVIGTAVNFVEIREERMRWLSGVVTCILLWQSWLGFWWWVGAGMWTGEAEDVERKREKARRKEERRRRKREAAAALAAAPSGSGSGSARGEGGVGSADGSATRSAVGTLRQRFQRARAATTGSDSGVPGAATAAESIELQQMRPVVDDSTATSPDAREANDQSAPVDPPAESTPRSRARPARSRVTNESRTDSNSSDLSSSGGPASEHFYDPLVDLFSPFFRRLRLAHETAALEQAAKPSALPEDVRRGWGIRALMMRGKMERGERRQAARGRIVDGAEMNVGERRAGFELDGGARLDEEEEEDEDADWQDATTATSDLDTPARTTAPAGRSTSRHAYPPQRGSTSPATSPSDPRAPAPPHPDELDRAERGRDGQTAWWWRGWIGRARLKDVSHWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3I4</accession>
    <name>A0A2S5B3I4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3I4"/>
    <dbReference type="STRING" id="741276.A0A2S5B3I4"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028641">
        <property type="entry name" value="RCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207:SF1">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="156"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="212"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="276"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="363"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="387"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="546"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="597"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="68116" checksum="82C065377CE0B661" modified="2018-07-18" version="1">MATSITQHIEKPWGRLLVAGGTDYATLGRKDKSNKNFVNPSHPDLQSAHIVRAVANVKFTNVFTSHSGCHAVALTLDKEAYLWGRNEHHQLSYPLPPTVTEPHLASNDKPSSTPMAPEPIRLKALPDANVPPALKEQGIVHAACGRGHTILVTDQGEAWSAGWNVLGQCGRPETEHISSFEQIKGTDGGFDKEKVIQATAGVSHSLLLTESGKVYAFGTAEKGVLGNGRTGEHIAGSRVIFQTAEEPLLVGHALEGKKIVQIASGQQHNIALDSEGYCYGWGFGGLGRLGLGVQADQLIPAQIPYFAGSNALTRCKKIAAGSTNTLFIDNQEMVLLCGKFKVSGDGSAGQPWMTPRHVPDLQGYRFTLVSGGGVTIFCHARDAKEGDFTVSWGQTATYGELALGEGAPKSATKPQRIEYLDGIEMLDLAAGQSSTFFIARPPPTQAAKDEAASIAEATAEVPAAKKDDEAPASTETAPAVKPSYDISGFGFSFGGSSTSRPEASTPKAASPKADEGAARRKNAAEISRTTNSAWEELQRWPPLFEDEACKVCGSADADKGVMLECEKCEGAYHGACLSPPIEGVPDGEWFCPTCDVPHAGAVPADDEAEDEEEEEEEAEPVKPANKKRKAAGGGAARGKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3M1</accession>
    <name>A0A2S5B3M1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3M1"/>
    <dbReference type="STRING" id="741276.A0A2S5B3M1"/>
    <dbReference type="OrthoDB" id="2529242at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="787" mass="83661" checksum="93C8C5659EB5A653" modified="2018-07-18" version="1">MARLYAIATIRPTLLLTVAVLSYLNVVRGRALPAGISDHLVWLPTVVLCALGAGLAGRIDEASRTAWICLLSWLTAATTVTVGCFGRLLFAILRVRRLREPEAPDDSQPHPARLLQSFWPNTSSLSTSFVRTIGRTSSSSASPSSRLSFVSRPSLEADPFARSPTPASTRHLLDRSASSSPQSLQLGTWNDRGRHDILTFEEIDAGKVPGQKVRHSTESNASPHPTASSVTRSAPEPAFRHSPQVELSASEAFGALVRVGGHLATATTSYALSITFVAYGSIGSSPSAGASYLLILGLCLPSLFLAWQTAASEGIWPSSSRTGSRSNADNASVDMRERSASRASTVGTYKESSCVDTVCTPQAAALASASRTHDFGVDSDETAHARSPALTPPAEAVPAPFNRDEAGIAGIATDANSQDTLIALSLLRSRKARSLYFDSSPDAGMHLVASELGVLAPAAGSGSSASEVKVHEKGPVEIDALTAHILPQLVPSLRIGSGVQIAPNSSASDRRRSLPIASLLDAPRGRSVLLRPKRNRSLPALSFTPPEPEPELDAGRAAEISRRTSGAPSLLSSPDRDRERTETDSSVSGFVLLDNETDESEASSEEEDPRTGTIHCATLRPVSRGSSVSFYGPTLSRHVTAMSLDSAASLTTTCESSTASLTFPERLSWGVWQDRAIVFDSELARRLSGSSAPSAPFAASPQPTATSNRRKDQPRPASWASSLCEMLESSLASADQDVIDSPSYRLSRIVQRDIVDETDENERTAAAIRRRTRPLSALGASPMRKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3W0</accession>
    <name>A0A2S5B3W0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3W0"/>
    <dbReference type="STRING" id="741276.A0A2S5B3W0"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000313">
        <property type="entry name" value="Importin beta-2 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000402">
        <property type="entry name" value="Related to importin beta-2 subunit (Transportin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="923" mass="101885" checksum="6018FF7C27F7CC9C" modified="2018-07-18" version="1">MAWQPNAGGLDELLACLRSSGSPDTKVQESVNERLEQFNNVPEYNQYLTYILTQLPAEDVTVRSMAGLLLKNNIRLRLQTFSPEVVAYVKANIFSAIGDATSMIRNTVSTVIDTLLVELSPENWTEALSNLMELVDSQDQLSQEGAFSALDKLCQDIPKKLEQLQIGGQRPLDFMVPKFLAHIDSPYPKIRNYALSCAIQFISPDNNALTVHLEQFIVALFKHASDDSIDVRKTVCQALVQLLATRPDVLIPHMGSVVEFMLYSTQDTDNEEVALEACEFWLTFAEDPELVNHLRPFLPKVIPVLLQSMVYSEDDVLLLDTDEDDAAVPDKASDIKPHLLSSKTHTNERLEDGDANGQQPGGAHMSRERADDEEDEEEDEEDYDEDDDDEAYTEWNLRKCAAAALDVMAVAFEAEMLDVLLPYLKEKLFSSDWLDRESGILALGAIAEGCITGIEPHLPILMNFLINSLGDSKPLVRSIACWTIGRYSSWTIKDDATPEHKQQFFVPAMEGLLKMCLDNNKRVQEAGCSAFATLEEEAGPELEPFLGSILGNLVYAFNKYQQKNLLILYDAIGTLADAVGSSLNNQSYIDILMPPLIAKWGALSDSDPDIIPLLECMSSVVIAVGPGFVTYAQPVFARCVAIVKQSLIDFQQYQQDPINFDEPDKTFLIVSLDLLSGLTQGLNTAITELYSASEPPVLTLLSVCLQHPDAPVRQSSYALLGDTAISCFPILKPLVPQFMPVLISHIQSEPRLAEVSVCNNAAWAAGEIALQAGADMEPWVNPLMERLVPILLSSKAARSLTENSAVTIGRLAIVCPQLVAPHLDVFVSAWCQALADIKDNDEKESAFRGICAAIQVNPGGISAAFGYFLNAVARWTRPSDQLNEMFKTILVAFKGMSEGPAWDAQLAHLPPIIVQRLRERYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B400</accession>
    <name>A0A2S5B400_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5734</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B400"/>
    <dbReference type="STRING" id="741276.A0A2S5B400"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="219"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY71421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="321" mass="34687" checksum="933880D04AF72526" modified="2018-07-18" version="1">MGILSRKKATPAPQAQPQHPAAAPPTISAPISIAPAPVAVAAIDQDKQHPTQTSPPGVTATALPAQNVLPSPPRSPVLAGYHGRPGEAYAQPTEQARHAGHMNGTANGTHSYGAAKMAPASARANYEDADMADATRHHYQPQQTQHPAVYQSHPVDASRHAQQPSTTSSYGYPAQAVSQRQVGRAAEATPQVVISPTPSRGSSTTTSRRTSSRYSLADFTFIRTLGTGSFGRVHLVRSQHNSRSYAIKVLSKERVIKMKQVEHTNSEREMLERVRHPFLVNLWGTFKDSKNLYMVMDFVAGGELFSLLRKSQALPTISPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B411</accession>
    <name>A0A2S5B411_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B411"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1508"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1534"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1587"/>
            <end position="1606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1803" mass="197969" checksum="09643AFCAD30D333" modified="2018-07-18" version="1">MASFRQLLAEGQDEQVSVNQRALVEKILARYSGEYTVFRELLQNSDDAAATNVELHFRTASNADSVGERQRTYPADSLPDLTMTKIAHIMVRNDGFVFRSEDWARLTEIASGNPDETKIGAFGVGFYALFSLTDEPVVSSGSKVVGFYWKGGGDQLYVKSAVNEAGLANTSSEGKSWTTFTMDVREPGPMPEPNDFARFLTSCLGFTQNLRTLSLHFDGHRIFTVTKTLAPPRALALRQNLVATSPQKLLRVTEIEEAPFQLKAEVSRWMTRSLPRPKPSVSALTSAAASSTTSFASKMLAAFSGRSSTSSRDLASHTAKPSGPGASQPPAPAPKDPLGYVPVTLFLRTVAASLKVSPSSHFANEMLRATKKALPSITRYSLVWTGKDEYEASRGAIGDSDESDARKVFSGLLPTDLGSVQGRVAIGFATHQTSGFAGSVGARFISTVERESLDFQSKYVAEWNRELLWAGGVLARTVFEHEMDDVARVWKQAAGPTGTSVEVALRTQLEKRVLHLVKFFTFDKSTPQEVVGSLTENSFFASNASTSPTLLSTVGPAPAHKLRLPSPQLAGFVKSIPTVPATIADGAPRFLSTLRDRGLVRDISLDDVFADLAAHALSIDEAAACFQWWTTLAADRSYNPRLLDRLRDATMLSVPEFESSTEVSIKPLDDFQTFVNPKTIPLDVPLPPHTLPFALSRQLSTGDLVRVFQYRELSLVEWLRYVSSSALTSKTAPVPTNLFVDEAFAEKLLAVLARAWQQTPVPQQNEIVDMASRLAFIPTKQGLKLPNQAYFPNVSLFDDVRLLILLKSVVALPSGANLRGNFERLLLALGVRRHVELQLIFTRLLVAGDWSHVQLLRYLVSVKETLSPAERDRLRKTSWLSREGEAKIIQPAGPDGVIPKPKTVRYRASELYEPLEPLRELGLPLLDWTEPPTKWRTSSDEGKLLLELGLNRTPPIDKVLEIAAGSDGHKRDKALRYFLDGYTTLGYASAYSPSKHSFAFVPAIENGRETLRAPSDVFGNSDAALLGFPTLAPRYSAEETRFGVRRDPPTDRLVSAIVAKPPTTVEQASKVFAYLSGQVSHFSNAELEALRWAPIVPTKTPQLRIENLPPMSLYFDTSDSSLPSGLRNLFRTIPDFGPAARPFLVACGVKESPSTSEIATLLVSDPSRFYDLAGSAERYLAVLRLLAVNFGSFPSTLRSKMKLSPCFLGTKRLAAAASGSSVLEIDDEDDEGGESTLVYQLARASELIINDEPAAFHVFQSEVLACPQEDLLEVLAEQLGARRITQLIAEQYFTSGAVNSTSPRVQDLRRTVSERASLFLSERRQQYGKNELKHDPEWIQKHLQVSEVTSIELVRELRSPQGAKRASAAASACAKTLPNGDIGLFVSKSLELDYFEVAIGLCKLLLAKVRANDALLLLTILQTTLKNLKRRGFNVDRILQARRSEKEAADQKVREDRLQAQLRAQSAPTPAQLEVAVSELASMFPDADLDFLRSLLKTQEPPILENAANQLLGAKDYPKKRSEPSAPRGPPQPQQLAAHGQQQAPMPPNGGGLLSNLRRQFGKGERPQAQLPPPPALTTAAEGASRQRVQSHQPAQGHTPGATPTSVDAIRANLTRAIQAARPESGSNVSNTVEQTEVKETEAYCDATAAADLAFVAEIGGLRFFASREVPSPIDFVSQNHDALLRYVSRVIRPVGDVFGLDPRALHVFHDLEGPLIAFNRNGSIYLNFRFYMAWHDQLVQEGRLDEPLISTFSSIAHELSHNLVKPHDSAFSFYFSSFTEEYFLPMAKLLQTASRLPVYSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4A9</accession>
    <name>A0A2S5B4A9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000076">
        <property type="protein sequence ID" value="POY71596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4A9"/>
    <dbReference type="STRING" id="741276.A0A2S5B4A9"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="53728" checksum="A11441CA10ACE80C" modified="2018-07-18" version="1">MSRPATSSVCAAIRTSRRSLASSVPSSSTNSRSTASIRSKRAEAQRHASTSAQPILAQRPAIPEEVIRRRPTSSSSEPIVADAAPTPSDEGVISDETHTFHAGGAAAPLTQQQLSLLYAYTTPPPESALAAFAARVSLPVAAAASSSTSASEPISLANELELVEQALIHESFWDGVRALQDSVALADSANRRFTNFHDAPLETTTQTTGGSVAHAHNGSLAALGNSLLGTFATELVLESFPHLPTRAAKAALTLYVGPKSLANVANLSWGVGPTRLERALVGKEDEGKVSRKDRAYGHLQQGRGGARKVGNEVGAKEGAAGPGLVRWNRKPMSPTKDAVLFEDALASVARALVGVVHETHGFAAARTFCRAHFLSRLLPPSASTFLASPAASSDILPLLKFSNPNRVLSLSLTSHGLPPLRHALLKESGRLTAHPTFVTGAFSGDVKLGEGFGSSLRMSEWRASEDALRRVYLGGGRVEGGAPTDAWAGAGEGAFKGWKNASGWTEVEHESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4H8</accession>
    <name>A0A2S5B4H8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4H8"/>
    <dbReference type="STRING" id="741276.A0A2S5B4H8"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="104"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="305" mass="32454" checksum="A4E866C1AC0BF7ED" modified="2018-07-18" version="1">MPVARTSSAAVSAVRAFARSVRPQPGPAAACCSASVASTSRALSGSARPHAAADLSTSQTRFTGTPLSSSGSPGAPGTSPQSRYPPGSGTHLYAPSAESQRAYLESLLDAAGEMPNRHLVDEQIAEKTLTHKSGVDKTAVYGRKMKRSEVHAVEREQAQERRGGHNEKFAFVGRRLLRLHLTQHLFSRLSSSNPALLSTVLTSPSQLPLSIESILDTKTLGASVGKAWRLEEALRWREVRGQDGEMTGLWKCRGSAVEGVVGMVFTTQGIDATNRVFERLVLPHLALPITLERALAASTPSAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4V3</accession>
    <name>A0A2S5B4V3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5169</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4V3"/>
    <dbReference type="STRING" id="741276.A0A2S5B4V3"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="50"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="249" mass="27925" checksum="A7E8360D1EE45FE9" modified="2018-07-18" version="1">MDRIQSTSDRKRRHDARRRSGGGGTSSSLVTLAWTAVLLSVLACIPTASAVKFSLTAHHNPTPKCLWNYAMADTLVVVSVSAPIAGNNMQRLDMEVVDGSKSRNTYQSKRGLKGETRMAITTHADADLGVCFRNVLDPSVPEHQASKYERLIDLDVDIGADAVDYNAIAKQESLSGLEVEMRKLEGVVKEIVDELNYLKRREARMRDTNESTNERVANFFYLTFTTLLLLGVWQVLHLRSYFKKKYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5A1</accession>
    <name>A0A2S5B5A1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">gluconokinase</fullName>
            <ecNumber evidence="3">2.7.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gluconate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4971</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5A1"/>
    <dbReference type="STRING" id="741276.A0A2S5B5A1"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="261" mass="28574" checksum="5290E7B54A09FFD0" modified="2018-07-18" version="1">MTARPALIICMGTSGCGKSTVGLGIAKALEIPFIDGDDLHPANNVAKMSAGQPLTDEDRIPWLHKVRETAVLLTSSAGLEALDNPTAPETADEAEDRAVEHELHAALQRIHPESLAARLEKRTGSDGQGKRPRQREAIVVACSALTVQYRNLLRGEEARFRLPDGREITSEKKLEPHIETFFVYLQGTRTLLLNRMQHRQGHFMKASMLDSQLSTLQEPHETDEVNISVVKLGTGADEATERGKEAVIGEAIEKMTSRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5F4</accession>
    <name>A0A2S5B5F4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5F4"/>
    <dbReference type="STRING" id="741276.A0A2S5B5F4"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="486"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="780"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="642"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="678"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="780"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="855" mass="87139" checksum="DCBA60D4A4867946" modified="2018-07-18" version="1">MMSIQSMLSPQHALDLAAAQSTGPWEQSNAPIPPASAATASTPQPTAAHSPIPGHASLALPPIANLAAYQPHASGSRPAGNGQAGQESTSAGPLPSPRSRLAGWSTQSHGSPRAGTTSIGLPPPASATADADADADAAAILSSLPRAESRSPPAPRQSQLQRLERADGSATSLSQAQQQTWAHISGSHGPIDRQGGGEAKVFADLGSGSNPATSAQGVKRDKASNVCTSCGTITTPLWRRDPQGKTICNACGLYLKNRRQPKSFEATPTGSPSPGLPVLGTAASQATTSSAWRTSPGPQPYAPSASNTSSHWTQLAAAASQSLQAAGPNGQAPRGQRPPVSPRTAVSLAQEQSTALPALPGHLAPPSAASETGPAAAASRDNHDPPAGSCPGGGVCNGSGGQTCCQGCPAFNNRVMYRTGPGGNAHKKGKKRADSEAAPPGADPTAGGSQGSPRQAASKSLASTGRATEKASSQDGGAEPSNVGVMECHNCGTRTTPLWRRDGEGHVACNACGLYYKLHGQHRPVNLKKPVIKRRKRVPAAAPGQNRAAIMEAHARGSNGTSDTASPPPFGQDGDSSYEADSVSSAPAPKRRKTTNKKATDVAAATASPNGFKDGEQEAGAAAAPQASPRNTLSELAAIAAHTAQQQQTSHLHTTQVGGPSGSSSAAGLGLQAGPHAHAPHSSHAHHHHHHAVPHTHVPHAHTHAPSHGHRHAAPPTLPMLANLDVPLSSSTISLRELTHLRDSLRDELVSARDQMIRLDAFVKRGDGIVHVLEAAIAHSSTEGSAPLPQVSSETPLAPTSRSANEEDDYESYLRSLPAMEAVKLPSRSAASASQPDRTPAGAGIKREGSAPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5H8</accession>
    <name>A0A2S5B5H8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4948</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000061">
        <property type="protein sequence ID" value="POY72033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5H8"/>
    <dbReference type="STRING" id="741276.A0A2S5B5H8"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="141"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="363"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="796" mass="87547" checksum="CF61750ADA05B3AC" modified="2018-07-18" version="1">MPVKMRFGSEEPAAGLAAAPAAAAAKATLAPHAAADDTASTSKASIATPTKRALNGGSMPNGKANGHENGSGKKKRKLVVFDEEAEQEAADKRAGIQTNGVGPRKRAQMDPEQRKKRLAEAQRLKPQREALPVYAGREAILRGIRENDTVVVLAETGSGKTTQIPQFLIRSDIPRASPRVVCTQPRRVAAISLAQRVAAETGCVLGTTVGYTVRFDDRSSPKTRLKYATDGTLLAEMLSDRDLDAYDVVVLDEAHERSLRTDMLMGFLKDIQKRRKAKFAEFKAKGKQVANGNAGDDDDAQTKQPREPSELKIVVMSATIDAKRFSEFFDSAPVLYVSGRQHKVTIKYVDEPQDDYVDASIKTIVQIHQHYPPGSILVFLPGQDEIEGMVASLRAYLPDIEKNLAKKGQITIAPLFAKLPAAEQAKAFVPAGPNERKVIIATNIAETSVTIPGVRFVIDSGMAKEKRYHAGTGIDSLATEPISQSSAKQRAGRAGRESDGWCFRLYTETAYQHMEKRSQPEIQRVSLSFALLHLKAAGQEDVYNFSYMDAPSVTSIQGALHRLHGLGALGEKSRITPLGRQMAQLPLDPIFSRVLLEAFRQGCPREVIDLVSLLGVKDQLIINTSATREQANEARQKFTHRSGDHLFLINILRAYEELDGTDEKKAWCKDNYISYKAMQLALDSRKQLRERAERLDLGDWEDTLNDEPEPIIASLVAGLFANAATKQPDDSYRNMMTKQVVTIHPSSTVFSKKPLGIIYDELALTTKTYARGVSIVDPRLLPRQAPGVFNALRKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5P8</accession>
    <name>A0A2S5B5P8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5P8"/>
    <dbReference type="STRING" id="741276.A0A2S5B5P8"/>
    <dbReference type="OrthoDB" id="25987at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Asteroid" evidence="3">
        <location>
            <begin position="148"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="662" mass="71489" checksum="6C2DD0670B8DDC07" modified="2018-07-18" version="1">MGVQSLTTYVKKQNLGSYVVLPDPLGETGIPLIVDGMAWAYNVGLVDTFQGGSYAAIRANTRRYIVYWRACGLQPEVVWDGPFDSSKLATVISRSEQSLQRSINYMRAPDALRGDYKFWSKIARLPPMAHMAIAAELEALGVPNHNAQGEADSPTAELAQRRNGFVLSNDSDYFIYPAQCRGYVPLNSVTYGPYNSARLEKVSPTDPPSMQFLVYQPAAIAHSFSLPVTFLPVLAALIGNDIANYAAEINTKRASKTQQWAGRVDPRELLRIAGTLSTCAAMPTETLAQVQDVVFAVLPRLLARPSNDPLIVANLATAAWSYRLDSLDAPHPTYPLHPRASDSPAQAAARSSYDAAYRSSRFSSFVLHVLKHGTVLLQGQVEMPEYQSPVVALGGPTRRWIYAVVREALGTGSFESAGMPAIVYEYARRGEALLPAQVDVPHLVGLLLENGADPNPFLAAPVLALPRATRFALVFTAVSFRPADPAVSAAVLQPPLVHHLPLLLALHHIQLVQGAKRPWSSHEILAAVFVSVLLDLAPTSIPVLIRTSRRGKPGLMAPRRTSMQRGVELVVTLVALNILAQVLLLLSPAPSAPTTTMGDSILGPTWTEPHYLYDGAAFHAFLEVDEATIWTVVAGCPVEVQAAVAGVLAALESSLGVPLMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B604</accession>
    <name>A0A2S5B604_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B604"/>
    <dbReference type="STRING" id="741276.A0A2S5B604"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="256"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="467" mass="49884" checksum="79F2C17793C98DB1" modified="2018-07-18" version="1">MDTSPTGQPRSRTTSGASSIYDWLPASWLGRQSYAAVDTRSDGHFDDDDDDDDLATVIRVGSQTGTQSTAEHSRVERLAVYQQVSNNSRSGPARTVAISLCRVPPPDSVSYADLLQYLASRIEDAAQDGAYDTVVFLDPAPYVPSLVQLATAYFSLSHTARKNVSRVCLVGGGWRTALLARIFSFSILSPRTLKRGKLQALSTLSELAAKVGAEAFRSLEIPLQVYIANAQRDGDLGFQEDEGAASLPADRSDGTLELVAVQIPPLVRDCLAVLAEQGPASVGIFRRSPSSANVGHLAGAYARGHPVRLDLAPDAPYLAASLLKRYLADLQEPVFSRSACETAKQCPLGDDDGAVAFIRKNICANLSPFTHALLCSMLPVLHAVSLNSSHNLMTSTNLVLCICPAFVGGIGASLEDVEMCRVPGMDCGTMKGLRKEAAGPQENSIGGVLRVMIDRFDKILAEDMPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6C2</accession>
    <name>A0A2S5B6C2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6C2"/>
    <dbReference type="STRING" id="741276.A0A2S5B6C2"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="277" mass="30629" checksum="F132BB7EC52B052A" modified="2018-07-18" version="1">MSDEQHTPCPACFQGYRMDGTPKGTMEKLGGLEYYYSPGKPDQKDKAIVIGVDMFGFGVPNCKIIADWFAEKTGWPVFVPDLLEGDHIDPASLGSNLDALEEPMAKKPFLTRMAITLGAVWTFGYKIGPRFLARHSMGHVVPLAEKFCHDLEKEKGFKSLGYVGYCFGGTVSVFLAKADSAVDALVCFHPGGPKPAEWANIAKPFLLVLPEEDFAFDRSKSTVLPMLEKVPVETKVIDDNPGTTHGFGCRPNMAKPQIRQAFERGLEHTKDWFEAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Q9</accession>
    <name>A0A2S5B6Q9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Q9"/>
    <dbReference type="OrthoDB" id="2527212at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="492" mass="53239" checksum="976B03E5CB5AE0BA" modified="2018-07-18" version="1">MASTNQQQLGAPGPSERNAVQGGQEPKNHPDVKLDDNGHLYIGGPDRAPSAFRKDPKTRTVSLPVKLLALGATGSDQYHLKQSDTDSRLELTVGINVLKVEQVAVADGKRTTWMTVAPTDISFVKASVNRWEIEREGSDVLIAVVFVVPGEPVPFVLLFEMDLQHHERTAENAHVLFFDRLVFDHMKAFFESWRERGYCSADIDPVRALAIPPPGKSFITRKPLPPGYDPHDSKTWIPPFGPVSAEQERLYFEPALQPSELEVGPSGTATTSFKADEPVAPVFTQSGRTVKRRVPNPIISTTESDGDPEGGPRKARGRKPAKRGRRRSSPSTSPNDVPQASHAIASDVHGAEAMPNAPPADVAVGMDIDQAEDAKPEAHPGGPKSSQDAPTPSQDAAAILLQLMIGMEQAAPVRAPDPTVHMSTSNSGPKPAPHAGQSAVEQPDMRLRGTNGVDADEEDALSSRRSRRTSSRPSHMQDYAIFPGARKGRQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6R4</accession>
    <name>A0A2S5B6R4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6R4"/>
    <dbReference type="STRING" id="741276.A0A2S5B6R4"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35670" checksum="592CD2D8CBF0E055" modified="2018-07-18" version="1">MDRLVQRYSKSAGATSRRYALENAQVEEYGYALPLGRGIEKCPVPAFDMPATVDPTAFLQLHTDDMSDPSCRIKINHGTTTLAFKFQGGIVVAVDSRATAGSYIASGTVKKVIEINPYLLGTMAGGAADCQYWETYLGIQCRLHELRNHERISVAAASKYLSNLVYSYKGMGLSMGTMICGWDKTVRKKKKKKAAVAFRPPQSADKASSSRPWLPQGPALFYVDSDGTRLKGDLFSVGSGSTFAYGYRYDLSDEDAIDLGRRSIYAAGHRDAFSGNTINLYIVKEDGWKFIENVDVNECHYDRGMAAAHTRTQLPATPAQPVAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Z6</accession>
    <name>A0A2S5B6Z6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">37S ribosomal protein S35, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Z6"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35044" checksum="E90DBDA38D4C16AF" modified="2018-07-18" version="1">MANFVQSTMLLRSVPTARTAVASTSRALFSSTARSHADAPAATPAAAEGEQDAEAAPVTEATELPDAPTEATVGATGPRNGYRAWLSGEGSRYRRPLQGKPNWIGDTPFPLNPTFNPLPPLADATKTRIYNAYLHNILQKDATDSQVVRAVSTKFGVAMDRVRAIVRLKELERKFRSEGRPLQTELLKGMESHLGVKQPAHESWRGIESPEPAVPKLASTKTVFEMVDVESGDSPVFLPLLSRVPLRATPLSEIPSTDSTVAPSSSSSASSSSPARRTKVVAASRPGRAPTAFVDLSGTPQGREMMKTYSGGTKRGAGGEAARRRARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B783</accession>
    <name>A0A2S5B783_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">medium-chain acyl-CoA ligase</fullName>
            <ecNumber evidence="5">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:48341"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B783"/>
    <dbReference type="STRING" id="741276.A0A2S5B783"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A synthetase ACSM5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051087">
        <property type="entry name" value="Mitochondrial_ACSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605:SF10">
        <property type="entry name" value="ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605">
        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="465"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="576" mass="63789" checksum="5DC72D6FB8604C33" modified="2018-07-18" version="1">MAQSEFHYDVLREKLKDGIPCPDDFSFPSHVLSHWAQKQPAQPALHWVSHDFKDERILSYKDLDELTHRAAKVFQDVGIKKGDRVLIQLPRIVEWWPALYGLMRIGAIPCPGTSLLVAKDLKFRAETSKAVAFIGDAESCARFEEVSKEVGISLIYQARTPGDGGLGKGRKDFQAAIEKVPRDTKCEASHKKTDLALIFFTSGTTGAPKMVLLEAEHLLGHTITGYWYQAKPGTVVLCMADLGWAKASYGSMGTFNMGATYYVQPPPPGAFTPNQLIDALNRYPIATLCAPPTIYRSLVTTSAKAYLKAHPPKALRHCVGAGEPLNASVIKEWRDMTGVQIKDGWGQSETVIGVGNFEGIAVREGSMGKPAPYFEIGIIDHEGRELGDGEEGELAIRTDKGAGDVWIFKGYVKNGKIDPRRKTHSGKTWYCSGDRAMRDTDGYYWFVGRDDDVITSSGYRIGPFEVESALKLHPAVAESAAVGSPDLSRGEIVKAFVILSEEFRDKIDGNKDAEEKLVADIQSHFKKVTAPYKAPRAIEFVKELPKTVSGKIRRVELRELEHKRKADVLKQQRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B790</accession>
    <name>A0A2S5B790_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B790"/>
    <dbReference type="STRING" id="741276.A0A2S5B790"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="182"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="336" mass="37460" checksum="AF8C05D5FD7D098D" modified="2018-07-18" version="1">MPHSIELPILDISPFLGTATGKESQALHTRAAKQLDHDLRSYGFAYITGFESVVKQEELDEVLEAARAFFARPEDEKARLKIRRGDGARGWQKIGENVTGGYADWHEGWDCYKPVMKEDPSQLLHGPNQWPEEPAEFRRVLEKHFAKMEILGHALMDATALALSITEGSEDHDQLKSWVPDPFWVARCIGYPPLPPDAKGVSCGAHKDYGNWTLLLADPTPGALQVFLRDPDGTNIGPDSQKRGVWINADPKPGCLVVNVGEMVEIYSAGLYKATLHQVVHKSPTYRVSVPFFFEPNYDAAISAESAREGRPQFKPVKYGDFLTAKVAKNFAFEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B792</accession>
    <name>A0A2S5B792_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Small monomeric GTPase</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B792"/>
    <dbReference type="STRING" id="741276.A0A2S5B792"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="160" mass="18079" checksum="96DAE311F4F8B678" modified="2018-07-18" version="1">MIDEEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRNSFDEIGTFHQQILRVKDKDYFPVVVVANKADLEHERQVGTHEGRELAKHFGSRFIETSAKQRLNVDEAFHELVREIRRYNKEQAAGRPGAAAASQPAQFQEEHNDSAGCCTGCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7C5</accession>
    <name>A0A2S5B7C5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7C5"/>
    <dbReference type="STRING" id="741276.A0A2S5B7C5"/>
    <dbReference type="OrthoDB" id="2537025at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="606" mass="64786" checksum="D9419F01BB728C69" modified="2018-07-18" version="1">MQCAACARTEPPRNGAWYCSSCISSRPRVTDLTRSIRSNSLKEYHTRRQQLKNGLTLVTVNATSLLTGSRNRVGVEEERLLKAEKWTLASRAYAAREEVTRAKARNQDGLSLMRACPGSQGSLVGRTCAATGQLMERRLGLASRRANLATARSLLSNLEASFPSASALSLPESIPALQARCAALQVELDTLRADSARARAILTQELVSVYGLRRIVVEQPLPDPFLAAPLTHSVAESASLSPARSIWRAQTAPEPIPPTYTLASLPLPRLSNLLSTLPSHAHLEALLSHLAYLIRLLALYEGVILPFVPLPSCFGAGRAGVRVAVGWGSAPKVSSNTAVKRSGDGDVKNIGLERDDGSSSTPTPSPQSSDRPSMTVSEGDCFPLCFGLSSHKATTRRRHARDDRDGPAGEATATDDGSEDGHSDSPRKLYQEEDGEDERSSRSRKKRVSTSSKRAKGVLLGAVALAFDLAYIAWRRSRRSGVHASTSPAPRSQQIDWWDPAVLDDLGGLLLEAAGVSLDHDRSASRASNAGGHKLPEGSPSPFPLDFAQAAGHFLALAFPKTPKPARAPGETGTSDSLGESGVVVGLDGTEVLDADDDDEWDFVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7D0</accession>
    <name>A0A2S5B7D0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secondary thiamine-phosphate synthase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7D0"/>
    <dbReference type="STRING" id="741276.A0A2S5B7D0"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015641675" description="Secondary thiamine-phosphate synthase enzyme" evidence="2">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23429" checksum="16808EBE085602AD" modified="2018-07-18" version="1">MSSSVHSLLFRTHLLAVSAACTATESAQRHLLAKRCFDLACDARLLRPSQLVLARLSLQHVRAYCRSTMSSEGGRFQTTIRLKSRPKGCHLITQEVTEALGDHLKSCKIGMLHLFIQHTSAAITLNENYDPDVRTDMDRVLDKIVPESFDWKHVDEGPDDSVSHTKSTLVGPSVQIPIGNGKLLLGTWQGITLCEFRHHPHSRRLVATIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7K8</accession>
    <name>A0A2S5B7K8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7K8"/>
    <dbReference type="STRING" id="741276.A0A2S5B7K8"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="165"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="616" mass="66972" checksum="F491BCD4EF44D10A" modified="2018-07-18" version="1">MQAPAWSGVADPQMEGNMNSKEMETWQQPQHSVLSDKISLAEYCEHLPRPPLVFWAQRQRAREKNDTIATSAPLAQLGRTMMGKMTKSEKSSDDDSGREVKASVTESGEIVDEPSGDLVGLSPYETELCNARRALRVAGWSTIFYLITTDILGPFNEPWTDSMHLITAPYAIASMGMGPGVALYIIFGIIAFITGCMLNYQFLHLDSIRFPVRTFGDLGGRLMGTWMRHLCSFLQAVQLILNVGLIQLSNGQGVAQIAAGHGSICFSIAVAIWCWLGIVIGQIRTLRGLGFFANAAVWINFLSMGFIAHSMHHVLKVATSLTHLSHSPPNYAAAKAAYGIDAGPVQVVAVVNQPVFAQVNGYETLSSLLLLFPELMTEMRRPHDFIRGMALAQALIIVCYLMYGIYVYAMQGQFTLALAYQGVSKYAWQTVGNVLALITGAIAAALYGNIGLKVLYINIVEGIFKGPPLMSKKGRLVWGVSVIFFWGAAFAIGSGIPSVGTLSGLVAAICIFQFTYTFPPLFMLALEMHKDAMKADEPFETAGVAPRQADTWRQASRWRRGIFGGTMKSTILKFVYFVFFLASLATAGLGMWASGTDLREALAAGAASSFGCASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7T3</accession>
    <name>A0A2S5B7T3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Single hybrid motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7T3"/>
    <dbReference type="STRING" id="741276.A0A2S5B7T3"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="29677" checksum="B6871C9BEB16E1D9" modified="2018-07-18" version="1">MPAMSPTMTEGSISEWKVKEGEAFAAGDVLLSLETDKATIDVEAQDDGLMGKILVADGTAGIPVGKLIAILAEEGDDVSKIEVPSEESVSSSSAPEASASASSTTPAAPSDAPTPSPATPSATPSAVHSHNHPHHPKPLLPSVLRLLVLNGIEDATSIKGTGHHGILTKGDVLAFLGKIPTARGSVPEDKPHGNHPANYYTATPKDVKKPVEVILDGPTMRRMIATGLGSAATPKPASPIAPAPSFSFDSILDDYLPPSKRSNVSSSSASSAVPPPPSAGSANPFDSLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B818</accession>
    <name>A0A2S5B818_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B818"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="80"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="8">
        <location>
            <begin position="1505"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="947"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1397"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="784"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1473"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2087" mass="228444" checksum="4E7D920340557169" modified="2018-07-18" version="1">MVDADDAEESAKKKGKQKKIERKPEGPTHEMRILDDDERDLGRNSLVDKYGAQLRVLTGEETAWVAITGSHARPTSITPIIYSVLQMISRGRDEGATAVRISKELGIEPKSVFHYLKVPQQLGIIKKFRDTEDGRWTNRALHVRYLATSPYWAVHINTEPDQGKEDEGEQDEDAAVEGGGGSQWGGDELSPISPLYLNTNKQVIRKRIVKALKRRKGHWMPHSELHTAIGLHAATSLNLRRLNTIITQMADDGIVEKILTTKTKSSGGQSRSQGLRLRDPDELHVKGEEDDSAVAQHRDIIEEVEEEEDDNDDDGSYPSAMRSIERQILDLLMNAGSRGVTNYEISATLGNFSLRFIDAILQKLGRTALPPALADYSIHSLHETIGRLKQTRWFSLVGYLSYRRERGFPDEDAEALWTAIEESGRLGQWEDDEGAGPREGQYATAAERQKRLASFNMWASVGDPAAGTSGGKSGGGKQRKKSTAAAKGKAKEVKQDSPADAFEDGVEARKGPAEKKRDGPARSTGRPRKHPLAPGEESTYMRKKREKAEDEERERLGLPPLERPKPPRKNARQPGPRRRRDKAASGSQAQAGEASPSEGMNGAAKDGQSQDVDQLDSAGPGTPSTAETTGGVDNDAGPAVPELPAEKAVPKKRGRPPKKQVSAAAASKGDVGKEPEATSVESVQKTLPPSKRGLLSADANSSSAPASSSPAKRSSRTLEPYIDIDLSLPPNKRAKATPTAVQPSRFQVAGPSTSGALAGSPVAGPSRSTEVAPGSDTDAAAAVPSTSRATSPLAASSAAASSPAPAAPSSPTSVATTVRKRVSSTRPSIVNKVNLTYLARQKELLDFVAASGGIVERTARLNEHVHAWGSAQTPPISKYMMDKYVIAEVLDLAVRGDRLRKTVASGKKGERVELYYLPPVDMSSEIARDFVKTATVSLPRPSRFAGLRAVAQADSDSENEEPPKGSQHAKKREREEAGLADPEPAHGLEGVQQYFRQQQAVLGRAHGVKYGLAARARQLHKWLASYLFSHADETKSGIVHDGDDLVIVQHVLLDAMPLSVFLHVVPLPVESEQLDAFLADDANGSISMRDLPADILAIVRPRLNKRKSAMWRCFELLMDLTLLSPLVVRADERGHASFVKPRAPKHASHWRFHRKVPLYAFADAKSPLIATATLDSDDAVAAYWQTTQGAATAKHREPVQAAHIPGYPPVYSGRGLFRREMLSVARWRETYQLAPTQRAFLCKLLQAEPDILSDERAQTLAAWARSLYAPLDVVAKYLADVQETGLPPEGGRKRRRVKKVVVGADGLETEVFMSDDEEPRESATAVMARKRKEAAEQQEQDWQGILDRFRRDHQQPELDTTIVDWLHKKFLDPRAGNKLDAKQLDFELRRLIAAEPASVSDGEDRQTIVPSSVSRRARQNKDPYAVTHGPKFSKPVSRTSRPKKVVVGHPGRAVAPLQSEDSVHSAAAGPDDGVDHQPKRLDQSAFLSEPLPPYPKLPQGKRLSRSHFSTEQDELLLDAEIVILVRAKAINARVQYAALEWFFPQNPASNLAKRIRTLLKRPEDREMHDRVVAAFSDVYKAYESTVPDPTPTSLVNFDLAAWIRILREKVNRRQLRLMAAPQRNDTPKAEELPGDLADLQDFYRLEIEDKTADVRSRYEKVWARYHITTALREDAAASGPYAHAWQGKAVMKNRSRAKDQAIAALKAVVSTADKDYTEADGAATLAPYVAEVDNAVEHLANQGVISKVEREENRRVPGRNFLYKDKFLDRFGPRLDMSYMQEASHFEQDLLGSTEGIFPLAPAPGEMMAFFDLVSEGMATLSIDTNTLTEKTLDVEDYQTRQANDDDIECTINIIPASEGQKRSAPANSFLPDPIVQPATLITTAEMDGAEAKLSGKTAQTVLHLLRGAGVNGVSLAQLGSRLGKETGATRADVAEAAATLAAAAPPLAFYAGVAELALVSARHWPEWSLAMPADNSSRFMPTFWTGVGAQVNAEHFQRAAGWVKGELKHRAGVTLVELVERAGSQKILAAYEVRLVLLALRQGGKVVCRDGAGVSPLDASGRPAERSEEAHIDWTCDHWFATGTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B898</accession>
    <name>A0A2S5B898_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY73004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B898"/>
    <dbReference type="STRING" id="741276.A0A2S5B898"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="34"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="183" mass="19726" checksum="0A143F86360200FC" modified="2018-07-18" version="1">MSAVNPTSAFPPTDATGSSKGALQGGAPASNAANVAKRLQSELMSLMMSPPAPGISAFPESDSDLTYWVGRLAGAEGTVYEGHTYAISLRFPPDYPYKAPTVRFESTCYHPNVDLHGNICLDILKEKWSPALSVSTILVSLQSLLGEPNNASPLNVEASELWDNVEAYKLELAKHYRPLEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8B4</accession>
    <name>A0A2S5B8B4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY73016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8B4"/>
    <dbReference type="STRING" id="741276.A0A2S5B8B4"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="7">
        <location>
            <begin position="329"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="469" mass="52380" checksum="361282EF7A6CDD2D" modified="2018-07-18" version="1">MSLVANAFLSDRSLKIRSKAIPWDGYQRAGLLNADDVKLVQRIANSQREKADSILDEEGEAYAQLYVRLLGKLSRTDTIQFILVLLGDFIAGESLLLAFKGVSLESSDDFVRLKSAAIISTILPYDSSPPSSVVEQVSRALSSMIRSPNEPEAQDVGVQCFESVLRVSKARQYAWRAEETDSENGENKQEAAPSAGDEQQQTAPKIVEALVHLLRGNPSPQMQYQLAFCFWLLTFEQKIAEQINARYNLIPLLLDLAKQAIKEKILRVVVSTFRNLVVRAPKQNLAPMLVAKVLPWIQTSLQGRMFSDDEIKDDVEFLAGELKSSFDGMTTFDEYKSELASGHLTWSPAHKNDDFWRDNAAKLTDKDREQLKCVSDPLLKTVARPTLMHFAPAMKRVLVQLLSSSNEPLTLAVAANDIAQFVKFHETGKKAVEDLGAKARVMQLMTHADPDVKYQSLLATQRLMSHAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8E7</accession>
    <name>A0A2S5B8E7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3877</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B8E7"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 9" id="KW-0698">rRNA processing</keyword>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="1654"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="domain" description="BP28 C-terminal" evidence="10">
        <location>
            <begin position="1820"/>
            <end position="1970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2101" mass="225764" checksum="85D20744972B2EC6" modified="2018-07-18" version="1">MSTSLAAQLQARKTVDSARLQSAKTLKNPPSFIYTPRHASSVTTADLHALAANSWDQLAAIDPFFGAHYKEVLGEQAKTLDRTGLTKEENDKVGKTVDRVLRALGRHMLLKPAGVVLEWLIRRFRVQDFNVPALIALFLPYHATAHFPSALNVIPETNLATTPFAALIPAKKTLAPLPLLGLIDLFPPFSRATIARPLLDFVLHLPLDYLKNGETPHRALTAFWLQAIAAYLDRAGTRLPDGERAAVLSTILEVLRSARSAPDTLVASYILVARFALHNPFDAETLRVVLKGVVTNRARSYVADEETDAALVTTLVVISQLGEEDLEVGGGKKFLGNSGWKSLIKTPKLDELVVQSANQYDSERFMKPFLQTLAEDALTSADSVALLSSLLVPRPALDSDDMMTLPTSMIPVVLSSCFAAIVSNPTASPAALERPLAQIYQRYPAVWTAQSAVYTARAKSSADQTATSRLMEAMGGVLGGSSKSASALVLSASAPDVALRVQALRDVVENAESIDAQGNSGFVHDTLVARLSEPEADIAEVLFETDALDVLHKFVTADDILAAVTPALQSKREKYLYSVLSYLAGPYVAAFPQQADAVVQGVFWPRLLATKADARQHVVAMSALKASHLEKSHAWLKGLGVAATTQQDLVTADTSGRIAEIVAKNMASCGATQHDELERFLLARIASDDKLAAVIALRLASKMERARRVTFASGVLRSLRVARRGLDAIAAADGDGLRQLVSSENSGTLSSALEQALYSRSADADTSRQLQGALFVGALKSVHPVAGASWSWLSPAVDFEEASAYGTLCREVYDIAHSHHGSSGAVALSNGLLEVLFSSLVTDDAIAFLAATYTASVVPTHLRLAALRDTSAFIEVLAGATAQSKGKVVDWQVIIPSLVVALSDPSDDKRVRVEALKALDTARRSLLAGSAAKVGTVYGRDRFYGPATAAGLKYLDLTDVAAYLDKLLGSRAELTLSPSHLRTLHASLLDVASAKESPKKRKQQPLSAKVATYLASHVASWKTALDARVKLLAALVDVKDKDKSLALVALVSEATAAGPVEGKREPEAEVEYARLLLAPYHGAPRKWLEGDDTQAIEVLVNAIESPDLSGLRAALRVEALNHVSQSVFATVRAGTRLELFRRLVRLAVEADGRVADDVAACLRSVKPDSETLSTFLGALKTSLATPLSKGAKRGRVSVGGSASSSSRTERLPELVSVLECVELASVAPSPALLLNLFDILAALVDLPASAGQTDIAYPGQLVLTALARLVERVTPELGVSGESIRMTPVLDFMRSSANPQTYHQALLLLAQLGPLVPDQLVHNIMPIFTFMGANVLQRDDAYSLRVVDQTLDSIVPALVKALQKTARGRDGLLRELKDLLRNFTDAAAHVPRHRRINLFVRLVDTLGAKDFLSAVVMLLVDKAGKATEDTVALPLALVENFAVDVQLATYRQIIDELGRILSFEPSFLVEAPNAPAGPRDLVSIKDQAMNLLGTLGFMLEAKQLLSKVDSARAAGSEAVDAGVSETVRGLLDLASAVDPAFDDLDRAQLADAAEYDVRAAVALLSTKAFADALLWLLEMADPAIQPRVFALLRARLPFVKATRRSDLTSAINAVTAAVQARLESGANGVVASLETLETIADAAVAEEDPALAKIVPHLVKIAGDAEMDPRIRSNALTVLKKLAHRLGPRLIPLVGKLVPFALELLKAQAQAGPSAVAAIAVGAFEVLEGLFVSVPAFIGGQVDKIFKTALSTAVMGLSTSHGPAVAKARATLLSTAAKKLPAKTLFPAIIRLHASLSQDERSPLLGLLDLLNRTLRYGKTADVVEHYRTIFKLFLTVFDLRRVHSDALDMDDVVAVEDHALGAFVQFILKLNEQLFRPLFLRTYDWAVIDLAEEVNAAEGLVARRTVLYRIVDRLLGQLRSIFVPYVAFMLDQTVEVLEQAAKGVTRDSALWAALASALTKSFDCDENGFWTPARLAKFATPIAQQIEVPPSVAPAGAYNALVTSYVALLGSHESHLKAFNSRLLHLTRSDDLRVKRAAIDTLEVVWEEVGDGMLGLVPETTPFLAETREETEGGVEAATRRLVKRIEEHLGESLDEYLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Q7</accession>
    <name>A0A2S5B8Q7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Q7"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Q7"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="146"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="559" mass="59953" checksum="8CCBC0659A4A90A1" modified="2018-07-18" version="1">MATLPNRPTAAVIVDHGITSSEPSSPTYDGSSRPPSPRASTARTAYSYPQTPDLDSYPPTAKSTPAPSRSGSHSKDPLLKRDRLASKNPLKRLFNLSAPRRQEEEERGRRKLSSSQVETGSRDSVRRIAAEQQAQQRGWISREMAQRIVGFGMIALVGMNDSATGANLDSMQEYYHVDYDKISIVFLANTAGYFISSMSSSFMLHHYGLQASLLVACAGMSLGCIVLSIAPPFAVFIVMLMFMGFGSGMYDACITIVVAHEEDGVLMSLLYSCFGLGAMISPLAIGAFLDRGYAWNRYYKEGPIRKLTLRHPASRSACRFYSPFAADQPPPDEAHDAPMSTAQAPGSTAHDQQGEVFHARTKMSAQQRMKRALQIRAVWVGTVLIICAFASTDILSAWSVSFLLSKRAAPAASSRYVLSGLWAGIATGRVVLAWALANRLGEKTFAILMLALTSGCVGVMYVRNFVVDAVALALVGFFLGPVTPKVLAAIGVRVPPSLKGSVVSLLVGLGLIGSSVGPLLFGVVAGRGGLSLLPAVMIGVSVVSIAAWLAVPKNRRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8W6</accession>
    <name>A0A2S5B8W6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8W6"/>
    <dbReference type="STRING" id="741276.A0A2S5B8W6"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="658" mass="72028" checksum="43067052518EADDA" modified="2018-07-18" version="1">MSEPTATTSALRDRERDRQATPRPRARRSASSATWRSAAYSAFTPPKPQPAGGRRRSHSLHESKYPFSATRAIQYGSGVLQSLDLPASLLSVREYLVGRLAAAERSLDALRITIEESDLDDAGIASATDDEDDGGADHDEGPSDDEDLDEVDSLLGSGILSPAVVSSPRERDELLEEISSLQAFIASATSFLAAMREEMPSLVSSARADDSPSSPRYIHFSLSPDAQATLDRFLEDHPLPSMPDFQLRSRAASSASAMLARASVELAGIRDALAEMTSNNLPTAYLPSMPAMPSSRSIPDLRTYFSEESARLSAALATFKDETSESLSAGLHRMQEGAAYVKDQGLAVMDEAMRMYHSALEIGRERLLRYEELPEEWRNNPHILHGYRYIPIEQYGALFRSMFQWHNETVNIQSHFIGFLSLTALLIYYLFFSHASPHPLVDPHPGDTAIAVLFVLSAMHCLLCSTAWHLFSGCATSGWFRGAACIDYVGISGLIAASVAGATYYGFYDHPQLANAYMTFNFVIGAIGMLVPWQNWFNQREYKMWRIAFFVSLAASAVAPIAHRSLLIGGADTLKFYSPAVPSVAAYLAGLLFYANQFPECCSPGSWHIGASHQLWHVAIVAAVWLHWRAMSDWSTTVALARLAGLDVEAALSGAVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B954</accession>
    <name>A0A2S5B954_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B954"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="415" mass="45829" checksum="2AF5B14341BFA6B9" modified="2018-07-18" version="1">MAPIPRGPRQLPPELVADILDSFVESAPSHAARTPNLAAFARVSRDWHDAATPLLYRDIYLDSKTRQGILGAMEGNEALAPLVRKLTLSGGNLTAPDFARMQAVLERCDAVTSLAYHCFDEEFAEDLTFFISSTWPTLQYLRADQSQNLYNFLSRLPKLETLVARYIEFPEPSAWVASPPPTPPTSGRSSPASSYFSDDSHGSTGPARPTFRLKRFDSGTSPLSANFQLLTSSSQASLRSLDVPISSLISQDLSGFSSLETLTLTLAERYLPVPEPDRPRAHGARDEARCLRRVRRLLRGIKESQVPLRRLEVYEPAYSSTKAFDADVFESERMLEAVPPSVEVLDLATIAVRADYLARAFAHVDVNEDLRVKVYSNCLGVRELILPSTVARSAGSAIGPMLATLYQRNVSITWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B991</accession>
    <name>A0A2S5B991_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
            <ecNumber evidence="5">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BMF94_3681</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B991"/>
    <dbReference type="OrthoDB" id="2100085at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06565">
        <property type="entry name" value="GH20_GcnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041063">
        <property type="entry name" value="Glyco_H_20C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF8">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18088">
        <property type="entry name" value="Glyco_H_20C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="1280"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="595"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1386"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1485"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1576"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1649"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1390"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1542"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1581"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1701"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1733"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1753"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1882"/>
            <end position="1900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="POY73346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1900" mass="209143" checksum="E9AAF0AD3427F0A7" modified="2018-07-18" version="1">MKQAAQQTLRQVASRRASAALVAQPLERPTARRPIRSAAAAAAPSPAGHRAFSAAAYRQQQQQQQKTEQEFKADGNEGDAKGTQEEQQQEQNKKKQQQEENDTTVEGRSPFAAFVEVLRDEVRKNREWQDSVKQLGGEVSKVQDSEAMQRAKAMYERARLTASIKENPRLAAAAEELRKAGIGLNDAVSHALKGMEETAFVRTLSKSAKVVGDAAYTASAPIRETEAYRAVAAEITDLLENAANDTQHGGYIDRDARRRRREARLAKIGKSKEAGMAARRLKVDENPEAGQAVQLHATANAEPKASRLPKPVADALANFSQQYAESDNPFVVMSRSVTGTIGRLFDETETAKVTKWVKEMDPTFTQEGFLRELREYIVPELVDAYVNGDQPILKQWCSEATYNVLVATLQGSIGPSLISESRVLDIRNLDIMSAKILENDVHVYVVSWRTQEVLAYRDLKTNEITVGDENKIQQVGYVAVLTRVAEELDNEETGGWKVIDGEAWQDVHAASGVDSGTKSTWLVHFQRDEQLQSGAMRIDCSHDDFTTVDAGQPFEVTVSYSPFRGLGHILSVTRGLASVPAGDVISNLEAGNVATPRRYTDSPAPDPMQEDTPPVEKGRADAELNGSGGASNSTRELKWSGNVGEQLRRDEQCLFETVGVMIDCSRNGVLRVESVKTLLRHLALMGNNMLQLYCEDTYSIPGEPFFGYFRGPYTEAELREIDDYAHALGIEVIACIQTLGHLGQMLQWPRYGHLRDTPEVLIAEAEETYQFISKMIRAVSGPLRSKRIHIGMDEAHGVSEGRYRQIFGYKDSTAVFTAHLRKVNEICRAAGLNPMIWSDMLFCLPAKNNQLSGYYASDSVVTTELANSIPDGIDTVFWDYYHTISAPYEAKIKQHWQLAGKAPWMASGVWTWSRFWTALPFTFATVRACMKASKAASAGVKHVMTTIWGDEGNEFDFYSALPGMLYQAEHAYTARVVDEVDATLLRRKFDGIVGADLDDYIYASKLDDTQPETQPIDSKTHYCPNLAKFLLWEEPFYSFLSPQYDRTYDLESHYSHLASYLEQAFSTDLSTMSRVSLPHSLADVPNNERLRLPYLLASVLSLKCHLRQRLVAAYKTNDREELEALGGSGSLSRMSRLRALVKRLHAQHRENWFATYKPFGWEVLDLRYGGLQHRLETMHERIAAYLDPDDTTVTKLEELEVELEVIYPNQGCFLMLDYARCSRPHPSDKRSELPLDGTLIAPGPLEEKRVQIARRRLLPAAWRLPGTHEKSRASIYNDLDAEMVQVPPPPSPTSQERLLGTLIVIVLRAKNLPNRVRIGKQNPYCTITYGLHKKRTDTIERGGQQPEWDAEFRFEILKDGFGGEEQLAAEQAAIVTHKGGVLPAPAMAPSTSQGSDVSSTSKVEKRTSKHSLATAVISTCNAGRRVLKVACWADDARDPKLIGEGELDIEETIRKGKYDDWVQLERKARYAGEVYLELTWYSNEPRKSSDQRRGSHRSPSRSGAAYGGAGSRVDDRSSSDTGTEEWEADTPSHAAAQLTAAKVQSGSSSHVSAPTELAADYPDPDVAPLTSSVSAMSLSRPPLPVPPLASPQAPPLSASGASSFATHPFPSQGHVPDQSQFAYGAYAYDGRRLSQPAYAASTYPQTAPYAPPASALPQHPSQPYMGPTASDFGHYAPPLLPQQQQSVPTPDYYATHPVPHPAAASPYPQYSSAPPLPDPYAHAGPHATLPSHSPYPAPPVPPIPPSGSAYWQHPPPQLPPPPPQHAQHATPAGTHSAPSYHALPHSASQPTLFSPPPPPPSLSAQYGQPAYPSPNGVFSPPPPPPSLRHDTPSYAHLSSPAPLPHDPYAYHGQQPLPVAPHGPPASAATSSRPPLPQPPTVPSAQQYQSGAPYSPSYPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9D7</accession>
    <name>A0A2S5B9D7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9D7"/>
    <dbReference type="OrthoDB" id="10605958at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015517745" evidence="2">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="119" mass="12575" checksum="212D70139069E25C" modified="2018-07-18" version="1">MSTLFRTFLVIGMLVSALIGLPVVDPRLDDTTRVAIEPRAIPNVKVAKTSSASITTTAVGNPKFTPIANPKANHGKWPTGIKVVPLWTVNGTTIWGVKPTHPGRPPTWPPAGSPTTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9H7</accession>
    <name>A0A2S5B9H7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B9H7"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1032"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1072"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="150"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="934"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="1098"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1338"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1343"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1359" mass="150828" checksum="70A5EAA48DE06816" modified="2018-07-18" version="1">MAPSRTSSARSADKVRQPRFVVADDSSGDESDRGAHQPSRPPPAIVIDGGASRKDIRSSSNHVGFVEPPLQEKQPDHGAAAANAADMQDGGERQRADPEKSSPSDFSADSSYPPTGRQAFDRPEFDTEPPLEANAHAKKSRLPPLPEFLAWIPPHLNWKGWRPVIRSSLAAWLGLLLMLCGPSGRALGQASFLVLVVAVISPAAQPIASQLETVFFQFFFVGVAWAWSCIALAIAHASRSTKFSKADFQVYAAQRFAQPGMTAAEIQAAASDAIFEGVFIEAAPSAVCAIFLGAGCGFFLWLRGWVGPGPMTFGLIFSMILIIISLTIGVLFPYAYYSIGVSDASCLVFFIPFACEQAIILACTFLIFPETLAHQFSDRLIAALQPLQTVIHDQKDMLRSNPRTDEWLRFKSLKVNANAAVAAVGLLGASEANLSREVSFGRVNGRDLAAILQKMRILVARTSGFVFFYEIVEKHLHREESDAKGGPVADDLVIHLGRSRAGTPSRTPASTRPHSPDREPSSLTPDDADSRPHAEQLGTALRGLQEREAGGGLRRASPSRPTRHFDRSQSSPGLRASGASFSSLNDIDTSASRTTHRDGDSLPSPDVHRAAQYHQGHYFPHAHARHRRHRDEEKRRSRSRTRHGKHSSSHASLPGLLHDVLHPHVDVRPVGVVESTVYADLEDYLSNPRDEEHLEEIIRLLAAASTSLIETVEESIRHLMDVLHRFKSLDNTVRAAFRYNQAEADETIRISQEQLDTLKRAITSYRETKRLEVVRPFAAIFDPFGTETRGDGVEHEDLQAPSHRGLFWCFQYEHVLLGVSEALVDIFETILKFEQKRRRPRIWFPDLRKAKFRSQQVDQYGEDDPEDLRALDTRNFSSARNPDYKPPRNIAQHVGVQLHHLGRIASRRDVLFGVKMAFVVGLCSLPAMFPSSSYFFYSQRGVWVLIMLCLTSNQFLGDVLFGYIVRVVGTIVGAALGLLLWSIAAQRGRGNPFALAAVCAVAFPFVFFYRVHMQPYVLFPQSRAARRLIHDLLRSIMTAILPSVTCVLVIGYSWKGAHDPSLSTVGYGFSVAWRRFVCVLIGISVAFIASFLPPSSRQKISIRRTYAKVVYRMGDVVCQIISFANCKAGPTKPPKIIVNNLAALRLRVNRTIQARAMARYELSLQGAWPGELYAAVQALIMEMLDLLGQLAMVISKLDQSWTKALLHRSQLANPRFLQDVLTTLQLISTALDHGTPLPYIYNPLLERFLKSPEALASGHAHGYGYEVQLGDDDVDGLPQHVDFKTICSLEYLRFSSGVSQVYAIINFTVKSLVGENYLLYGLEERQNRHDAEEKRGLLAQHFPGHDDSRRSSFDGSRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9J8</accession>
    <name>A0A2S5B9J8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_3729</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9J8"/>
    <dbReference type="STRING" id="741276.A0A2S5B9J8"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY73391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="143" mass="17049" checksum="E7E14FFA4E807BB5" modified="2018-07-18" version="1">MLRFVLVQNRQGKTRLSKFYVPYEDDEKARVRGEVHRLIAPRDQKYQSNFVEFRNHKIVYRRYAGLFFSMCVDANDNELAWLESIHLFVEVLDAFFGNVCELDLVFNFYKVYAILDECFLAGEVEETSKQVILDRLDYLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9L4</accession>
    <name>A0A2S5B9L4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9L4"/>
    <dbReference type="STRING" id="741276.A0A2S5B9L4"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF2">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="48743" checksum="0DEEDB2CBA771AD0" modified="2018-07-18" version="1">MMRSRFPPASAVSPATHDAQTGSSTSSPLLEKTERGDRREQSSLGRRERPSLEVERPRWRGYRPVQTAWLLISTVALLVILAVERRYSNRIPFHYPLPRPVGNTTFAPTSERQIPPYVHYVFGLAPPSEVNQFNFIHYLCLTSAVVELKPEVLYFHYLYEPASWYWQRFKDELARSEMTRLEMVQERDVVEVFGNPVEHYAHKADVLRLEALQKYGGVYLDADVLVVRDLAPLYRLEAVMGMESQPNLDPKLPPSGLCNAVILAKPYSSFISRWIDTYRTFDKTLWAKHSVTTPWDLARAYPTEITVLNKFAFFWPIWDDDSLRVIHRDDRYNFRKAPSLAPTWDAPFACHLWESAAYERYLSPYDPDRIHNRGKKHGPEREEDGASDENSFSREARRFVSDEFRQAWREAKAQGLVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9T2</accession>
    <name>A0A2S5B9T2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LIA1</name>
        <name evidence="12" type="ORF">BMF94_3456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9T2"/>
    <dbReference type="STRING" id="741276.A0A2S5B9T2"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="325" mass="35263" checksum="6E3C009F9328287A" modified="2018-07-18" version="1">MATSDEDIYSGLDRQLNSPEVPLAQRFRALFTLKSLGGERAIQVIAKGFDGESALLGHELAYCLGQLKDPRALPILTKVLEDDNEHVMVRHEAAEAMGAIGSDEALPVLRKYLKHDNAAIRETCEIAVDKIVFDNSDAGKTAGPNQYPCIDPAPAAASHSPLVSSAHSAALSPASSDIPIPELEKTLLDTQLSLFERYRAMFALRNIGSRDAVLALAKGFDDESALFRHEIAFVFGQLSSPDSVPSLIEVLRRPHEEDMVRHEAAEALGGIATGDCLPVLKEFAQRDDVPRVVRESCVVALDMYEYENSNEFVPLPTLPSATASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAF0</accession>
    <name>A0A2S5BAF0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAF0"/>
    <dbReference type="OrthoDB" id="2535970at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="551" mass="58593" checksum="D064A8BBCF8A7F34" modified="2018-07-18" version="1">MSATTSARDAEPSFGKRQHQERSRRQSLPSNLPSSSRRRMSGLAISDGTVDFLGSRPVSQAGPHVQFASPPYMPMYGAASSSSSDAHRRSMPPIGSTASISSLNSLATPSRSGRPGHVRTESSRLRRRLARWTSWSKPQDGGLEFGCAGTNDWSEGPVDMSDRYYSPYRGTANRGSFSSSAGSTSAAGWSHSRGESTSSTFSTVSTAPSSAPNSPTMRAAAKQQAVPSSSAGEGTVTPRTAERMRSEAAAVEAVDEYFRRMRLAAPEASSTSSTSGAFSFPQRPLSSAPTSIDVELARSTKSDHKRSLSDELQIQFIETGHTTFTPFSASQLDDDDQSSLVLSNEDLSDDGDHSTYVLSEVTPIPPALFEIPEEYSGSNSTATTARPSLAVPDLVVVDGVEEDLVPALEELSDYFASTLSVEAIERDVVPVPQPAEWIPVPIEPLSPRRRVATKPEVPDLSKFAFPPKAAATLSPSPPPGVSHARGGSASSLPVIASAPAVGLEPPQGHRRGQSASFAAAERGKLVAAGQLKPSLAEQYLLRDRNVLYNWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAJ5</accession>
    <name>A0A2S5BAJ5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAJ5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="399" mass="44301" checksum="3C776275DBF4FFA6" modified="2018-07-18" version="1">MSLFMPAHRRAQPLQSTLKYAKAPEPLEELCPNRCGLDSLPLELLRKVISQVAPGSVSDTQRTLARLAMVNKQLNHVLRDDARGSVWISSPVNIKEPVAAAAGGAFTSARTLIATRKNTPELEVVHIYGTTQQRWSDDLRGPDLAAWCFQLPQLQSIYLHGLHVREMKKKDNLNAERAFPLDSPILARLTSVSIKDSAVTFNSADAPALAACQHLSLCDFVHWQECPQGTGPESLLCAEPNHLPQLKTLRLSPLFVTGKKDSPSHRLPSLPIELVQQLEAMQVDFGSAEFSHAIALPLATPLFQQEAELLGFEYVQIAETFLDTCGELCRILSASTKLRALFFDHTLLRRYPSWPKPLDQLLSDLKMKGIDVIASEPDAEECVLPEFLEYLDAQKRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAT9</accession>
    <name>A0A2S5BAT9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAT9"/>
    <dbReference type="STRING" id="741276.A0A2S5BAT9"/>
    <dbReference type="OrthoDB" id="7318948at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="753" mass="82812" checksum="2D263D269A93579E" modified="2018-07-18" version="1">MPRPTQPARAHGGRSETREVIIVDSDTEESDGSIEIQPVPTKFAPLPPPPPPRPAAPARPRTPLAPAAVKVSASGGGRPHTELQLPSSSAPSDTLANRPPSPDHPLPHRPYPFNILNHAPARDPAPPLAYKAPEQMTTAERAEEHFREEEREERDRAQRKLREPAGGEWEWEWSKVKVKGKDKEERKHQPAQTRHAASFFPHVHLPGLQHMRNVFAVVGGNTIELHRIEDASTSKTTDLPTKILARTKLNRDYVDESDKEQLFTCAWSVNITTAPYTPVLAVAGRGRAIEIFLVAQRSDGEWLLYHDRSITGHGGSIFHLTFHASYPHVLASCSEDKTVRLWDVAVPWGSDRALQTHMAAWRRAGRTSKRIWTERPRVEGELLAVFAEKGHERAVFSCDLHAVQPLLVTCGADGYIRMWHIPRAVFESTPYWPSTPLFTPPEKPRSAPRQPPVLGPPFFSTLAIHPGQWPDQVLFASPTTCAVISKAGVSHERAQHSPRKSVKVWVPTILDVLPDMLAGPAAALQLRPDSGIGAASGPSEILDLSSIQTCLPTDARSDGAFRIAYEAVVEDQNCVGDKIGWYRPPRLRRRDAAALVEDAFFAIPTGSILPLSNSASSSSDRPSLFFFRPFALPPSPSRVRSHTKTSGESSTAMRRTASLGTSQSGSNLVPSHIHTPETLAEALFPPDRDRDAHDFTPRLLPSFVTDELAGAGSRGQELAHARCVAVDPDEAKHVVAVGDGGLLAVWTRRQRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAX8</accession>
    <name>A0A2S5BAX8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000032">
        <property type="protein sequence ID" value="POY73932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAX8"/>
    <dbReference type="STRING" id="741276.A0A2S5BAX8"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="135" mass="15494" checksum="8CBC18D99B1CF9E5" modified="2018-07-18" version="1">MVRMLESDDAAANADVAVTRTDQDRINAFSRLNSRADEINELLEGYRKEKEDLEEVETEMELVDEDEQVMYKIDTTFVHLPASEALEQLSASLEKIRTQVDALESEKQQCEDKMDELKKELYAKFGSSINLERGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB11</accession>
    <name>A0A2S5BB11_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII28-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB11"/>
    <dbReference type="STRING" id="741276.A0A2S5BB11"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="145"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="249" mass="26196" checksum="69911BE4A9DB1545" modified="2018-07-18" version="1">MAPKRPASNAGSPPPSTAPPKPKKPRAPRPKKPKKNAAAAAAAAAAGGSQAGSPPPAGSAVASPMPPASSPPVSPSAARSGARDGSATPHGGKGKERADTAQPEAQEAAPEPEEQDAEDEVFEFSDDEFGDNQAEAARQKEDLRVLIEHFDENQMDRYEAYRRSGLAKASVRRLVNSVLQQSVSPSILTVVRGFAKVFVGEIVEKARQMSDHPGSLTPQDLREAYRVYLQEHQGPGAGGASHAKKLFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB64</accession>
    <name>A0A2S5BB64_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2814</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB64"/>
    <dbReference type="STRING" id="741276.A0A2S5BB64"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF2">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="641" mass="69820" checksum="7FB6C48AD9317AD6" modified="2018-07-18" version="1">MQNSSTHAVPVTPKKIGRGHGAGPVEPVDAKAQAGPSPALSEHAQPTGEWAPTAPAFEELPPSGVPYLPAAAAVAPAVPFPVGKLSTRTSRKHLTSSPFTIPLSPAQASLSYSLSRLLSLPRFAAFLHTPLGYAQFAAYLAGDPDNKTLSELELWKDTHVLGQLVSQAEAGMRGISNVYLTGDNPTGPVMTDETRRLLFDALSHKWPGHAQLDRVSKQLLESLYRKEFEGFIKTRLVRHTQAQLAKYNLKPEDRGGIGSSFILTNPRLRDDPIVLVSPGFCELTGYTPNQIIGRNCRFLQGKATDPKAVNTVRTKLQDGQEVLQLVLNYRADGTPFMNLLHVMPLRDLDGNLSYFLGGQASITTALTTGTDLSLIIPEEENPPADMMAFSPAVQLEARNPGQQWVIPPPELLTPIPSAPASESLPSSRRPSEGREPVHVDDDNAMSVHKLCFLPAKFVVAFRRLIGLDKEHAQAMSEKEKAKEQEGGATPKHEELVAPSQKDMRTMTLEQRLLDIQVTYDRLVVIKRASREILFTSASFLRSLGLPGTTRQDIDRSPLIYLDILELLVSPSVPTPTSAATKDLRANVKQALADAVPCNFECGFQFRSPSRNTSFPLLKGRLHLAPLLNMHGEAVAVTAVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB70</accession>
    <name>A0A2S5BB70_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB70"/>
    <dbReference type="STRING" id="741276.A0A2S5BB70"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26227" checksum="F7532161F79A2BC4" modified="2018-07-18" version="1">MSAPSAPAPQPSAEDLALGLFARASLDLFDVWPALRLAISHGWGGNGTQGKTALAEDVVDLFYTVATSGGAASSATAAATAAASTSTQEGGVPIPAQDEVEQTLLYVIGNEFDVDLEDGSEAAIARDLIKLWRECIQRVQAQLASGAPTSDEGPLAKDFRERAERARAQDGQQRFAAQRQGGQGGDDDDDETTSEEDDDDDELDEDDEMEGVIDEPVPQLVEAQRPEPVVDEDGFELVQPKKKGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB95</accession>
    <name>A0A2S5BB95_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB95"/>
    <dbReference type="STRING" id="741276.A0A2S5BB95"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="526" mass="56993" checksum="68224EBE73B102FF" modified="2018-07-18" version="1">MNTREQSTWASMDARLSSFVGALALGDLVKSTLGPKGMNKILHSTSTGEITVTNDGATILKSIALDNPAAKILVNISKVQDDEVGDGTTSVTVLSSEILREAEKLVTIQHVHPQTVIEGFRIASKAALQALEAAAEDHGRVFVKDEKQFREDLLAIARTTLSSKVLAADKDYFAELAVSAVQRLKGSTDLDHIQIIKKQGGKLTDSYLDEGFILDKKIGVNCPHRMENVKIMIANTPMDTDKIKIFGARVKVDSTGKLAELERAEREKMKAKVAKIKSHGVTCFVNRQLIYNYPESLFAEAGIMSIEHADFEGVERLALVTGGEIASTFDNPQAVKLGHCDAIEEIMIGEDKLIKFSGVAAGEACTVVLRGATGQMIEEADRSLHDALSVLSQTVKETRVVLGGGCAEMTMAVAVDEEAKRTEGKKALAVEAFARALRQIPTILADNAGYDSSDLVAKLRAAHYEGRKDAGLDMEKGIVGSMHECGVTESYKLKRQVILSASEAAEMILRVDDILRAAPRRREGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBH3</accession>
    <name>A0A2S5BBH3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBH3"/>
    <dbReference type="STRING" id="741276.A0A2S5BBH3"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="206"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="366" mass="40224" checksum="F13D9E9554CD6965" modified="2018-07-18" version="1">MVVLKTGLGERLISNDVEGKAFSELPVIDLQRLQGTNEDRKALAAEIQEVGPVFAISVERSPPGSSAIASGFFYISNHGVPQDVLDNAFGQAKQFFSQPMEKKLEIDQSKGNSFKGYVPLKGENVDPESRGDMHEAVDFGPEQGAAMSAEQTSGNMWPSAEDLPDFRPAIERAINEILALGQRLFPLFALALDLPEDFFADKLKNPGSAMRILHYPPQYGPVDTKEIGIGAHTDYECFTILAQHGDVQALQVLNSAGEWVQAPPKEGTFVLNIGDQLQRITNGLFKSTVHRAINRTGQDRMSIPFFFGLDYDAMLETLPSCVSADRPAMYEPITAGEYVEKRMKETYVKAPKAEEVKAPKAEEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBL1</accession>
    <name>A0A2S5BBL1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBL1"/>
    <dbReference type="STRING" id="741276.A0A2S5BBL1"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="672"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="735"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="814" mass="89720" checksum="60D2B76FB24B0B9D" modified="2018-07-18" version="1">MLDLSRKLSDPPPYASATRSLSVEAGLSATVDQRCRPPTPAILEAKAHMDVSPRARRYSRGGYEDERHERFPPLRGKRRRSISPPGRGGPPRGPPDDYYDRPPRDFRDRRHAADGYPDRRPPPPDAYGYPPAHGGYHDPYGAPLPPPPPRRPVLEPPMNLPYLVSHRYFSDWFHASQSDALSGADFDKALDDAWTKYQGDFLRRELKASWDDVRMRALQWADEKYGISAEREQERKETRRLAEKDRRMRKWTSKAKNGDFDDVSFDFDEELARKPRIIPNAAAQAAAAAEAAAKAAANGAETDAAAEPVKETTPIPTVLKASSPEHVILPARPEMIVCPAVPPMVSTRALVDLFKAFEGFLRLSISDPQPHLGFSRVAWASFDSSETASAALSTIQAAHMPSAASEGDVSKANGVPLQTDAAANGKPAEEPKGDAEPVDADMKDGPAAPAAPPVSAYSIGPYDLTRPGLLSVRLEPIEVRARAAPSLTSRPERVRKDLETALQAVEAVEKKVLAETGLGEAADAATAEAMGSAFLREKRKAWEQELDERREKDSLEEVAYQAALASIHKRTLDLALAYLRDAMDVCFYCCAVCDSPEQLSDMCSRHVRRADNSSDPNRLAMESAWIGGFDRRVPLLTDVSTLDLRDFGAESREEEQYRLLAPHVKQEEEGKFRCKECNKLFSARKFVEKHLGLKHPEVLGTRLDEVAVYNNYVLDPSRVPLAMFQCENYLPSILNPPPPPMPAPPPRRHDRPPPLSDRLGPPPDKRRRRDPVEKGPPAPPPKGAALDPRAQRGATAYSDLDGPGGAGGDIVLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBM2</accession>
    <name>A0A2S5BBM2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BMF94_2738</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBM2"/>
    <dbReference type="STRING" id="741276.A0A2S5BBM2"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="POY74164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="377" mass="43970" checksum="3816894564EA72FD" modified="2018-07-18" version="1">MSTAAEKRAAKRNRIYLREDVAKHNKPKDCWVVHNNKIYDVSVFLEDHPGGDDLILNYAGKDVTEVMGDPVEHSHSDSAYQLLDEYQIGRVGSEEKITNPDFEFTDDWHPEDTDNKSDWERNQFLDLDRPLIMQVWNADFSKAFYLQQVHQPRHMPGSARLFGPWYLEMFTKTTWYTVPLIWLPIAGYLLRQSVVQQLARGVSLSTTLSRTGACFLLGNFIWTASLILEYTLHRFLFHIDGYLPDRPFFLMLHFLLHGIHHYIPMDRMRLVMPPLLFFVLQAPFTRLAHTLFPNWMANGIISGSFTFYVLYDVMHYALHHTKLPEYVKQQKSWHMMHHYKEPDLGFGVTSPFWDRVFGTTYVSQPASTSSQSAKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC29</accession>
    <name>A0A2S5BC29_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC29"/>
    <dbReference type="OrthoDB" id="2524554at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="724" mass="77097" checksum="65E944AAADCB4D4B" modified="2018-07-18" version="1">MIRTASVAVRRVRRPALPPVAATWLSPRTAVESRRHYARQPSFTTPPEPAEPPSSSDAETAAQANRVSAQAERVLDSYGSPFQQTASSAYTAFRYAVFGSVFVAVSSLAAFTAAHLYVEYVALAGPRPSDDDDDPDEWATEVEGWTGSHLPNQHGGTDPRLGLWTRMAIRAAWMSQNWGSGTVAAPETLAGAASTVRGGSTAAASPFAVPSAPPRRIGDSPGSAAATVAGGPSEVGGGGVDSQAARQVHDAGWIMAERYLALALRRAQETRGISLVDSSDWEAHIEHGGVDRAAVQLEQRLAGIRARIGGRTRLYKAREGWERIYYALEASPSDPTTRKEEAEWERREKVRATRKLGDLSARIADSWQVGSDERESELERAEGWYLGGVIPLLAAVEGQSLAGRALDELVVSPAQPQPQEEPRKHVSPSSSFFGFWSRSHPPSSSSTPSRAPRPPLGSTAGAAELDHLIALLSAAPNNNNNDKNGSRTLSPATERAVLASLISLETQFARRASTAASSPTYLIDKATTPAVLLQRAQALQSAALAYAQSLAAARPLLPASVPPTTASTVESSSSSSSSSLSSITAADLSKRTSALWLSTRLAALETHLSECRLALALSERKTSTFGGGGRGKTSVPVDLADADALLLATSRAEQTSDASAALLAAIETYKDKNAKELRKVYEEPLKRIRRDADKVVEMGTGLSEVVASLLPRAKEERTTNKWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCB5</accession>
    <name>A0A2S5BCB5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCB5"/>
    <dbReference type="STRING" id="741276.A0A2S5BCB5"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="518" mass="56563" checksum="CA5B9059406D4905" modified="2018-07-18" version="1">MNGTTSTAWSPQSWRRKPVVQDVVYPTPAPLADGAEQPDPVSYKRKQALDDVVSKLEKLPPIVSPTEIERLKAKLADVAQGRAFLLQGGDCAESFDYCTSEKIEHRLSLLLSMSLILIWGMKLPVVRIARMGGQYAKPRSKQTEIVDGREIMSFRGDNVNGIDPSDRLPDPERLLSAYFHSAATVNHVRSLLASGFASLPSGSGQVPWSLPLAHVRSEELLKSYESIVQQLSSALEFMEVIGVERGNSGASGAALESADIFMSHEALMLEYESALTRELAVPAFAAKRACEKGFYCTSAHFVWIGDRTRALDGAHVEFFRGLRNPVGIKVGPTMEADELVRLLGIVDPNKEPGRVTLISRYGADKVDEKLPAHIKAVQASGHQVVFAADPMHGNTKTSSAHPGVKTRHMHDIVYEISANMRIHAQMGSRLGGVHLELTGDVTKDGESVTECLGGSMQLEEEHLGLRFESFCDPRLNFEQSLDIAFMLSQAASKGPGNQRIFDELALPPGSRTASPARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD58</accession>
    <name>A0A2S5BD58_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD58"/>
    <dbReference type="STRING" id="741276.A0A2S5BD58"/>
    <dbReference type="OrthoDB" id="2150628at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051667">
        <property type="entry name" value="Archaeal_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096">
        <property type="entry name" value="YALI0E33429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="72696" checksum="7E7CCC2D7838147C" modified="2018-07-18" version="1">MRRVAGDTSRRLLSASQANPSSWLVAAEVGRQTKRASLRGPPLRALAWRDGSRRTFFGIGEVIGVLTNPTEVLRNLTESKKMLEEARRELKESQERAQIPASHTFSPLPGFFDRPAEIQVLERSLGSVPGFTVLFGASSVGKTALLRQVLSDDKYHVVHFDLRIAGFADLASLYFSLSTQLESYFAAIPDKLGREWGWGEFEKESFAFKHDRLDVQKRLENGGEVKTSDIAHLLELFQSALLSYWNFQPMSNSERKAREAAKKDEKEKGRQKAATSKTSKQRDHPVSPQEAKDADKARSKTGAVPKPEQEDLHDSRSLQAAEAQVGDDELRGGERRTGTTTDQGEGKEEESKPPPKMMPVFFLDEAHKLPALIQSTEAMKTFLDSQLVLTKQDRLCHIVHATSDPFHLHWLRQLNVMQHCNILTVGDCSKAEAQRYFTDFLLPHVPDKLKSRLSFEEVYKVFGGKLAHLSDFVGEFVNSDGDISPRQSTHFLQAHALLNLHLVHAEPSEPGDEDSTGQGFAIYSSLRAASPHASPSPFGETDKAEFSAADFLKVMQHLQPGGEDSLRYFPLCRKLGARAVDGMIRGRLLELRWTEAITEEGEQSAEARARRREAVGPRVLPTTPVVRYAMGEVLAEYHAEGYTLPSASDLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD66</accession>
    <name>A0A2S5BD66_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 5-oxoprolinase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">3.5.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD66"/>
    <dbReference type="STRING" id="741276.A0A2S5BD66"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="595" mass="64214" checksum="D7C1E66CADD061A4" modified="2018-07-18" version="1">MATPISLDKPDPILLTLFANRFMSVAEAMGRSLQLTSISTNIKERLDYSCALFAPNGDLIANAPHLPVHLGSMSFAVRWQVNHLGIGKDAPSGNGIVPGDVLLTNSPTAGGSHLPDITVITPVFDAENKDVIFFTASRGHHADVGGILAGSMPPTSTTIFEEGARISSFKIVRGGKYDRDGLYERLVVEPAQYPGSSGARNFRDVESDLQAQISANHRGTQLLHGLIDEYGLETVQTYMTFIKDNAEFAVRNLLRKAVQRAGKNVLHAIDYMDDGSPIELTITIDEEKGSALFDFEGTSPESRSSLNAPLAVCSSAVIYCLRILVDEEIPLNAGCLAPITLKVPPESLLNPSETAAVVGGNVCTSQRITDVVLRCFEAVAASQGDCNNFTWGVDRIEKDGQVTEGWGYYETICGGAGAGPGWHGESGIQVHMTNTRCTDVEVLERRYPVLLNEFSIREGSGGKGRWNGGDGVIRDMTFHIPIQASILSERRVNQPYGLKGGEGGQRGRNLWIKQRRKEDGDWKENDSTPRTINLGPRNTVKLGKGDRFVIWTPGAGGYGKVGDTDPIEPTKPKPKQTLVGMVGSLAERAAAQLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDC4</accession>
    <name>A0A2S5BDC4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide hydrolase</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDC4"/>
    <dbReference type="STRING" id="741276.A0A2S5BDC4"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="8">
        <location>
            <begin position="362"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="569" mass="61381" checksum="3B6396FABEF8EF54" modified="2018-07-18" version="1">MSRTVRRGARSTGAVSALVTACLSAIVVDAARLPYTASALKSTNLVVIPRDTSSGARIQVASGCATYQGQVGSSTLADLYLVDDANEQCFSESDVTGAYGTQYRVPVATKSKGRGDVGSLFWLRPDTIEIASEEAEYSSTDGSAQVVLSGASVPASPAQTIKHLLASLDPTLAPGHVLDLPNAKEEGALVSLSVHDAAIRLVQLEYLTSHPLLSHYSLIAVTLSLEDANAVNDAFPAVPPKSIERVKAHLDHLRFQPTLSAVLKSLEGEKAGSRIRRDVQVLSGEDQSSLSRQEKWVSRHSMSEGGFRASNWLHSQMSAYGFNCTQLPFLTGFAPMVECVYRDSGLGNDDGDLVEASRFEMQADETVVLGAHFDSRGSFGYPTAPGADDDASGTSLVLAVARHIWQRRLRFSRKLVLALYAGEEQGLLSSSFYAQRQRAANEDVVFMLQVDMVGYRKPGEPMQLARPNLIGLPEAGWFVGNVSSLYAPELVVGRVHAAYTPACCSDHQSYVAQGYPATWIFERNGPIADPCYHNSCDLSKREGYSFEQIAAHTRVAFATVWEIAGGRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDG1</accession>
    <name>A0A2S5BDG1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RmlD-like substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDG1"/>
    <dbReference type="STRING" id="741276.A0A2S5BDG1"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="334" mass="36217" checksum="C3064222ACBFE7D9" modified="2018-07-18" version="1">MTRTLVTGASGLLGRAVLEAFEAKGDEVKGTAYSRAGGSLAKASRSLGTLVIDGSRPMTLQRSCGLQLDLQDDEAVASLFNDFKPDVVIHCAAERRPDAVEANSAAVEKLNVGVPRLLSTLSRSSDYPFFLIYISTDYVFDGHAPPTGYEPNDATGPTNAYGESKLAGEKAILAGLKEGGKGCVLRVPVLYGKVESNGESAINVLVDSVRKAAEGTPVKMDNWAARNPTCTRDIGRVLRDLAVKSQASDAEIPAILHFSAQEMFTKYDMAHIFARVHQPPLEVRDNLVRVDEGPKPGETIRPKDCHLSNRAIEALGIDTRTVKFEQWWQEYLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDP3</accession>
    <name>A0A2S5BDP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDP3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDP3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="73" mass="8062" checksum="7F7D5A80A563BA53" modified="2018-07-18" version="1">MDQLAEQISSACQVALDPSPSVAQEQRHGAYTFLQQVKDASGETWQACWKLFLERDAATSEARMFSLQVVGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEC8</accession>
    <name>A0A2S5BEC8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEC8"/>
    <dbReference type="STRING" id="741276.A0A2S5BEC8"/>
    <dbReference type="OrthoDB" id="2588793at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="528" mass="58912" checksum="13F150B81FFE3A52" modified="2018-07-18" version="1">MSYALDRSHIAPFVSQIQHVRQRSSVSRIGGFEPTVRRSYDGQPSLDHLPPSPPLMAWDPDSPPSRTPLPKRPTLPQKKKLTDGLLSTTLAERAPLVWRAPSAAGNARKGKSSLTVQALAALAMGGFLLVLCAIRSSDESFSLVPPLRSSVRKGPCDPYAAPGQLQVDLSDPDLNRWHPNDVSCQTPRFFQQLRSLNDRYQRGTVPASDFDWVRGKTVLLVGDSVSREHVENFCQLMGEDAEVIRPTHKWSPAPAPLRGATRVHQGGAAHSRRNMPRPTAATFHDAGRPRMCYIPQFDLLLLSVLHYGLDQDNYWALSRHPLYTAPGPFEHRISDVVRPLLANIRADGRPSAPDYIEFAPGAWDLAKFAEEDAVLQRDPQAPLTRDRVAWFRHRVEAASHRIRAAFPSAHAKTLRTMYYPLDQNTEVDYFMDKTAATKSNGTSVAYFAHERVSQLNEALRSLSTDRTTYSANGKQYEAPGLGFSINDFGRILKGHPPHQTDRLHGEPVPGGYVWADTMLYNLWKASQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEH5</accession>
    <name>A0A2S5BEH5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BMF94_1799</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEH5"/>
    <dbReference type="STRING" id="741276.A0A2S5BEH5"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 21" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 21" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
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            <position position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="133"/>
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        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="176"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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            <position position="177"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="POY75167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="193" mass="21691" checksum="7523A140EE97F768" modified="2018-07-18" version="1">MAFFSDIFNYFWDVLASFGLVNKNAKILFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGNVKFTTYDLGGHQQARRLWKDYFPEVDGIVFLVDAQDAERFHESKAELDALLAIEQLSKVPFLILGNKIDAPGAVSEEELRYALGLNATTGKGKVPLTDIRPIEVFMCSVVMRQGYGEGFRWIAQYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEJ3</accession>
    <name>A0A2S5BEJ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEJ3"/>
    <dbReference type="STRING" id="741276.A0A2S5BEJ3"/>
    <dbReference type="OrthoDB" id="15433at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="138" mass="15475" checksum="2B235AD6343E2089" modified="2018-07-18" version="1">MLLGVGVDLLSLARLRSVLSRRNPARLAARILSDVEVKEWHALSTKAERSEQFLALRWAAKEAAYKALYPAVIPRWADLTVSKQGPKPVLSFSNSPRFPRPSEPDFDRIRMHLSVSHDADLLIAYVVAEVRETQVSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEN8</accession>
    <name>A0A2S5BEN8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyroglutamyl-peptidase I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEN8"/>
    <dbReference type="STRING" id="741276.A0A2S5BEN8"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28236" checksum="05061D458C914F6C" modified="2018-07-18" version="1">MAAIELESDGSKPFRVHLTGFGPFRDIAVNPSWLAVKPLDGEVLSEPPPPLRTQSAVASPSTETADRGIKLRYRPVHLSTSLLPVEYSAVSDLAPKLQTDGEEKPDLVIHVGVSAGDSAIRLEQRARKFGYNSPDAAGKLADAGSEPEGAGRSDSRRRGFVGKEWEAAPEELRTRVDGAGVVRWCKSQGVDWVSLSEDAGLYLCEYSFFASMATARRLRPDAPTLVQFVHVPSVGNPYTAEELTAALRLIVWAIAADLPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEW0</accession>
    <name>A0A2S5BEW0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEW0"/>
    <dbReference type="STRING" id="741276.A0A2S5BEW0"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="41"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="516" mass="55205" checksum="67C6025A7EB7ECF6" modified="2018-07-18" version="1">MGTRSTSASPPPHVEDRRPLLDEDSDGPLPDKVQGRDGAATLVSCIANLANTVIGTGSLAMAHAFAGEGLVPGVFMVLLCGSTAAFGLYLLTRCAAMAPHRAASFSSLSNLTYPGLARLFDFAVALKCFGVSISYLIVIGALMPKVRLQRKIPMSADSRSLKRAQVVHSFNPDLSHSVFLDRRLWILASMTLLCPLAFLRRLDSLKLTSYIALCTIGYLVFVVVFYTFVDDEALPPPGDLELFRFGPSFIQSIPVQVFAYTCAQNIFAVFNELKSNTQARLNIAVGTSIGSAAIIYEVLGILGYLTFGSAVGGNLIEMYPRNKIVLIGQVGIVILVLFSYPLQLHPARASLDKFLFPQRTAAADTNGENASLVGGADADHGHGDGDEIPLGRFVVESAALLFTTFLIAMFVSSLETVLGFVGATGSTTISFILPSIFFLSLFKDSESPHDRRMRFLAMLLLTWGVCVMVVSLSLNIYHLVQQPAQGSLHTLGYLGGKVVAEALPLPAAEGGAATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFA8</accession>
    <name>A0A2S5BFA8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFA8"/>
    <dbReference type="STRING" id="741276.A0A2S5BFA8"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="206" mass="21361" checksum="D7809A0E83D20F34" modified="2018-07-18" version="1">MATRPQQQQPASHSSRTQTITADEAQPDPGSSSTPQPDQGAPVGSLRLRGRAMPGQRVQWAQETIDNEGLGRKKSKICCIYHKPKAFDESSDESDSSSGSGADSDGSRDSRQGGRPSSSSSARRRRHHHHHHAHSHGEGEECTGSHASGSSSAGTTRRNGSSSTMLEPAQPQDAPKPELNAYERSGGGGGGGSSGGCGGKGKGRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFH7</accession>
    <name>A0A2S5BFH7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFH7"/>
    <dbReference type="STRING" id="741276.A0A2S5BFH7"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="384" mass="41158" checksum="12646D7AB2ACB1DC" modified="2018-07-18" version="1">MMDRAERRSTLISLSTATRTRAMAESPKDALQLLLPLDDFVPVRVSTHSEMTPLIRFCLEQLVQHGENRRAVVLHTLPVSTSSDSAATSGSSARPNATFNAKQVEAAIAAIPKLVSVLEIIKREYPAAVQAALTSASATSSSRPVRKPRRSTAGLHQYTKLTTYETAFDYHAEVPIAEQETNRDLEAVRQELVQLEWLTGSAGKAKRCGFSQQEATAESFVKLTRERSVPVRPRQRHSPCMLAVLSSEPLAVLTKSSDFAYQPPTPLAKSSKKRLRSQPASSVPATAASQLGPQTSTPLPAQDSGADSTGAVAAGSVPAPHPSAQAGTDALGSRMDAAPAEKRRKPTRRKMRRKKPEQVAVRGMHAAPAPSITGEAASAMDIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFZ2</accession>
    <name>A0A2S5BFZ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 69 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFZ2"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="69290" checksum="728535DFEA88886D" modified="2018-07-18" version="1">MRHSIESLASEGGERSRDDTPLLPQHTRDCDTKDERWRARIVCAADDSDDDDLHGHGRRTDRVRTDSDEAAYSKRIRAHRRQHRLASLAYSSTLICFAVSCILAAGVIGWVAHFLYMRHEAYSTAVFARPLIPEPVSVEERVPPFVRSGANASPGYVSSRNGAEAWRRADVEQELDRRFRDLDLPGGHSMHDLSCVDLSQLSASTLNDRYYPLRSANGTSAARQGRTLLALNLFNSQDLLPSLSQTLLAVADYLGPASVHISIFENGSKDHTTTMLAHLAAALTALGVDHTIVSDPRETDWKAVDRIDQLAVYRNVAIEPMRSQPAAGWGDVVFINDVYVCPADVLELLFQRKAQDADAACAMDWRRTKGLGQRWRDGIKFYDNWVSRTLRGGMLRARADVLAEFRDGVDELWDQPGEEYSRERFQLGLPVPVYSCWNGMLSLTAEPFVSTASSSRYNLFAPSTSSETWRRPPPIQVDRPVQFRSALNHMGECAASECKTLAKDFWSRGFDRWVIVPSVRTTYDLETFSHPQLVELVSRHSPSQSTLRLEPPAKTSSDDATEPSERIRWSDLTPPQEIICWAWVRGFHLDFEIIRASWERPWAYARSLITRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGC6</accession>
    <name>A0A2S5BGC6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubinuclein middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGC6"/>
    <dbReference type="STRING" id="741276.A0A2S5BGC6"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="3">
        <location>
            <begin position="396"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Ubinuclein middle" evidence="4">
        <location>
            <begin position="516"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="87017" checksum="8B4CDCD418CBCC53" modified="2018-07-18" version="1">MPLPDVHPDGDPFAARDAEREANSFLGKLEARAQLEEERQQLPKHHRESMQQQQQQDAPSSELVSSPAPATRKPPAAPSTGSALKTAAATAATSGLGTDSNGKRLIVIESTDDEADNDGGPEPDTEDGLTTAAPSEAPEPNDQDTDAAAAAASGPEDEEEEEEEEAEATGTEADEGSEDDDDEDDGTPQVDDVAAEDESEEESDDDSDDDDTNSMTSERAPRIKDGEIEGEVVGPDGVRLSPKKKAAGEDGDVEMRDGEGATPGKEGADGAAPEKKKRRRRAPRTPTPPPLAPKERRATVRLSIALPPRKDDSAPDFNIQQLAKDAGFVKEDEPEKAEDEEDDEGSESDGQGGRRNKAKDTANGDGERTPGANGENEPPKKRRKRGPNVVLGRFGGYDVNDPFVDDEEVALYEPRYTAKPFREGYFVCAGEVDVAARRGRVKGSKNKPKVDENGNPVAPTAARRRSGKIVLGADGKPVADTPEAGPSGAQSPAVGALPSFGAPNGPPPPKQRKKGEFSPELQEKLDMLKAESDKEPWIVKNKFPPALKDKLVEVAHFALDIGEYDEEFYNVMPKIFPYNLFTMKKLIKREVYPKRIRDLNEEQDEQLQILKQGIDRNYGPQRADFERRLAEYERKLAQGDGTTASGVAVNSMRRTPEPAAGPIFGHSPAIATPLIATVDGLDGSPAPGKEEDEKTKEVEEPKWRFRLDESMRAALYRASEIEDKKSELTVEKQELEKATTRTYDREKPYSSKTARKVLYEKILELWPPGAMNSNLLSREISNYKLKLKKHGDLPSGPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGD4</accession>
    <name>A0A2S5BGD4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGD4"/>
    <dbReference type="STRING" id="741276.A0A2S5BGD4"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37805" checksum="18CDDC90412CDB82" modified="2018-07-18" version="1">MVRKSATTAAPSPQLAVASAPASAMSAPSSVKSIRRDPLLVEHYIPRVPLQLVAISFALLAPLDKGDGSQSRPERFLTALVENPVKTISVSSALVAVVQVWFGYWARSCRLRALREEEDRKYGRSGAGTERAQARPPRRGLFATMRYIWSNQLRPFGSGPQMRRPDDGRPSVKLDTSFLPQTLLVTLVGAAAFHAVAVLLGASFVHNASLTAMLSLFLSLLTITPLSIAIPPRDSDANRYTWLRLSSTLRPANDLELALFAPALGAIIGCWSGAFPIPLDWDRPWQRYPTTSVLGAVAGHAIGSIVSLLTVSYRAAVRTASEALEDVKRKERETSSKAVPAAAKGKGKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGL4</accession>
    <name>A0A2S5BGL4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0985</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGL4"/>
    <dbReference type="STRING" id="741276.A0A2S5BGL4"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="167" mass="18711" checksum="BBA2C241353934CF" modified="2018-07-18" version="1">MPKNKGKGGKNRRRGKNENEGDKRELVFKEEGQEYAQVLKMLGNGRVEAMCFDGEKRLGHIRGKMRKKVWINQGDIILLSLRDFQDGKADVIQKYSSDEARKLKQYGELPETAKINETDVYGGEEGDDMVDFGEVSGDDEPGVAAQPGYETESSEDGGKEDFDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH52</accession>
    <name>A0A2S5BH52_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal RNA-processing protein 7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH52"/>
    <dbReference type="STRING" id="741276.A0A2S5BH52"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="268"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="403" mass="42187" checksum="6AE8FA0CCDB3921C" modified="2018-07-18" version="1">MGRLPTQPDMAQVIPLRSGFYALPLNNSKTHLFARLHHGHTDDLAQDDDATEGATGTTKQLFVTALPAGVSEKGLKAAFGKVFGDDNKVKSVRFLANGTAHSYSTLLEKDLLTSQVQDGDEVPAPLFDPSQASASTSTAAPAPQSAILTFASAPSLPPPSYPASTPLTLPVAPAYLAVSAARHALARPHRSVVIAHVDEWMRAYDARKLAAAPATYSAEAAAAEAAAEAKRAKKQKGRKGKAVDVGPLPGSAAEALAKHAAARARYNDASFNPDEAEEGEWQTVSRGGRHGKSLLPTGVVPTVSGYGGVTVKVAGKKRGRLADAETPKLDAGVRKIVGDSFYAHSRAQARSKELAHLKARFEEDKTRVDRMRTASGGGRGGFRGGRGGGSGGARGGRGRFKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH71</accession>
    <name>A0A2S5BH71_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH71"/>
    <dbReference type="STRING" id="741276.A0A2S5BH71"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="65015" checksum="924DC9EDF7D8E7FD" modified="2018-07-18" version="1">MADSPGYSSEDTAVDSRKGSQPSSPTRRARKQATQQSFLLATRAYDLLECIVYPPLAFVLSCFNSVYQHIVRLLFVSPGGPHINPIPHGRIAIIGAGVSGISTAAHCVDHGFKVTIFEAEEGVGGVWARENSTSQLQLNSILYRFHPSIEWSRAFPKRDEIIEQTKRVWEKYELQKQTRFSYRVTKVQRDPDLSTDPREGGHGRWIVNDGKEGIFDAVVCAIGTCGAPKMIEIEGQDDFAGQVLHSSQLDKADLKGKRVVIIGSGASGVEAAELAVSKGAKKIDVLARSDKWIIPRNSIFDIMLSLQPFGREMPLSFIPEWIIRKFHYRDLEDLSPVKKGLFEGTPIVNDEFLQHIRQGKIAYKRGDTKKITRQGVLFNERERGTKSGEDGEETMLSADVIIIATGYKRPSIDFLPKDLFPKDKDRDYHPPSLYLQNFSTEDWSVLMTNASYQDGLGTVGNWHIGIYARILLVFLLDESTRPQPAAMKTWVDVVNWIKKGAWGENSAGLAFFTYAELIIYLFIFHFFNLRRLPWLPFVLFGWGVRPGRPYSVTVDAFKHGEEKVSAAVHQLRPSSHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHD6</accession>
    <name>A0A2S5BHD6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHD6"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="94" mass="10227" checksum="263C60DE18AA3884" modified="2018-07-18" version="1">MNLWEYAYPYPIALRQFIVKQAFNQFDKDKSGKISAAEATKLVQTVAPNTTEEQVRNAMKSLDKDQDGELSKDEVSQLVSKIMSGGGGSGGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHG8</accession>
    <name>A0A2S5BHG8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHG8"/>
    <dbReference type="STRING" id="741276.A0A2S5BHG8"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050620">
        <property type="entry name" value="Thioredoxin_H-type-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438:SF463">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="109" mass="12264" checksum="A81754E3E15C892B" modified="2018-07-18" version="1">MPVTTIKSEDQFKEVLSKPGFKGIEFVAPWEEACKAITPKWKQLAENDRWKEIEFYRVDICDQQEVAMTAGVKSAPVFQFYSGEAKVKELHTSTASELERTVGAVLAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHG9</accession>
    <name>A0A2S5BHG9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHG9"/>
    <dbReference type="STRING" id="741276.A0A2S5BHG9"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="51"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="271"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="567" mass="62410" checksum="3DB4B10B7F8EE0F7" modified="2018-07-18" version="1">MPMNFVATQSLPGGPEPAHVGTKEVLIQRALARLRSIPGPLERYTFLASLRNRNADVFYGLVGGNMKECCPIIYTPTIGLACQNWSLIHPPPTERDDKVSSLYLSYNDLPNIGSILRDLRTKLPHDEMEISVVTDGSRVLGLGDLGVGGMGISQGKLSLYVAGGGVNPKALERLKAGAPGSPLLLRMPQTLPITLDFGTDNEKLLADPLYLGLRQRRLPDEDCEKFVEVFMKEMHATFPNMIIQFEDFHTTLAFPLLHNNREIYPCFNDDIQGTGAVILAGAIRAFRLNGVPLEDQKILFFGAGSSGVGVAETICKYFELQGMSEEEAKSKFWLVDSRGLVSHNRGDKLPEHKKYLARSEPDAPKLRTLQEVVDHVKPTALMGLSTVGGMFNKDILKSMASYNKRPIVFALSNPVAQAECTFEEAIENTDGRVLFASGSPFDPVEYKGKRYEPGQGNNMYVFPGIGLGAIGARVSKIPEELIHAAAQGLADSLTPDENARNLLYPDIERIREVSMALAVAVVLKAQELGVARNEELKGASRSEIEHWVQRRMYHPLLQAEESQALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHN5</accession>
    <name>A0A2S5BHN5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHN5"/>
    <dbReference type="STRING" id="741276.A0A2S5BHN5"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="62"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="711"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="794"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="871" mass="93472" checksum="124E870BC117B825" modified="2018-07-18" version="1">MTEKAVRQLKTNFEKLGARLGENLAEHSRDLGLVDAFASGSGGGSGKYLESGAAVTPAGIEETKRMLISKREFERTEGLKRVIAMMTKNLPVTSFFPLVTSLLSPTTSLQARSLISLYIVHCASHAPELALLSINAYQKDLSDPNPLVRAGAITTLSSMQLPDIRELVGMAIQKGARDSSWYVRRATADAVRALYRADPTRDNLAVLKPTLKALLDGATPLTIGAAIGAWEELCPDDWDLIHQNYRRVCKMLMDVDEWGQTAVLRLLTRYGRSFFLDPATTGRTDSDADLALKSSEALLQHLNPAVVLGVVKLQYYLGSSARQEKCVKLLLRLLQSSPEVAAVALENCALIAEQRPDLLANHLSTFFVRFSEPVEGRRARVRILVALANEGNIRTVLQELTTYVEDVDDSFASVAIKAIGTCAERVPGVAPECLKTLTRLLQSSHDPTVATAVLVLQSLVRSPSFPSTASRSQVIARLASYLYTGKVTDPNARSIIYWLVGQYAPEGLLDGCGPDVVRLGAKRFTEESVLAKLQLLTLSAKLLVLAHLSTSSPYVRPLALIFDYLTLLARYDLAYEVRDRARFLAGLIQCGAIGKASTGGAGSSQNGDGAKMMLEEDDFRKGIMVEDLAGDSNGIAAEGEKTTLTAQQVRAILFDGKHFAQDTDRSSESDAQLGTFTLSLPGKRPFASASDTLATLPPYSSNVPPSSIRDPPAGSAPSNSTSTSASRASSRSATPMQAFGSDSFRSDTSAPNGSRRNGGKVVLVPSDSGSCARRIEPSAAAAKRGKQSLNDFLAAEEEEAEEESSSEEEDSASDDEDDEDVAEEDDTDGDDDDDDEEDDSSDSEASDEAGAAGTGEGRTERLHNAAGRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI14</accession>
    <name>A0A2S5BI14_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-nitrophenylphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI14"/>
    <dbReference type="STRING" id="741276.A0A2S5BI14"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36639" checksum="76C8568A4F9E5DAA" modified="2018-07-18" version="1">MVQANTTQDIRLDGHADELEIRDKKDVQALLDRYDAFLFDCDGVIWHLDDREKMTPDAAETINFLKDTGKKVNFVTNNGSKSRGEYLEKFRKHGFNVELEEIHTSGSATAGYVRDVVLPDISDKSKRKVYVIGSDSFEKELQANGLEWTGGTDPEDKEELPPFDYSCIKADPAVGVVVFQFHTQITYKQLTKGFNYLASNEGCRLICTNDNETMLIENGGSAPGAGALLKVLLAALPEDKQPVIVSKPWQEYMDQIRRRTDFDRRRTVFVGDRVQTDVLFANRGGLDSLLVFSGRTQPDDLHHLTAEQAPNYTMSHIGVLQEGKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI19</accession>
    <name>A0A2S5BI19_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI19"/>
    <dbReference type="STRING" id="741276.A0A2S5BI19"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="12">
        <location>
            <begin position="251"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="591"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="608"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="681"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY76395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="714" mass="79220" checksum="662BB7EE2AF539C0" modified="2018-07-18" version="1">MAYTLPRSALYAFQLPPELLDALSPRQLVIPASHPLHPANRQPDSPDGTSDTGEAPPPDSVKPAGHGGAYTCALTGASFPTLEGLKQHYRTDWYRYNVKLKLQGKKTPVTEPEFTRMVENLTESISGSEASTAPSDDSEAATSSESEANLTRLLRKQHLASRQAGHAGAAEDEDDDLDVLAAGPRTALQWFEAPKVAPDTQYGMYRAALPSAGARKRPLAGAEEGQAVLRELRELQLKSDEPTTGSIDGDRERKWTLLMFGGGHFAGMVVSLRPKLVRSGKKGSKEKEREVVVLQKKTFHRYTTRRKQGGSQGANDSANGKAKSAGAQIRRYNEAMLNDEVRALLNSWRDEIASSELVFLRCSKNNYKTFFGYADDAPLQKGDSRIRGYGFPTKRPTVNELLRAFTELTRFKTSHLTADALAQLDADYLASIAPPPTRPTPSSTSAPPKAKVDAPPKLSKEEELERDRWARLVEMVKKGRVEALATFLEKYGPELESGHEGEETPPPWGTLPPFLAESKTTPTLLHLAAASGQPSVVRYFLSPPYSLSPVLHASHLPPHTARPFPTPYEVAADRATRNEFRFAAFRDPQRCDWTGSGVGGARVPGGLDEEKEREKERKEEEKRAKLRERQRERDEAEAKQREMEEEKERQAREAEEHRRRMLVPAQASGPQRLGGGPPKPIQDRDRAGLSEEQKMRIQREERARAAEARLKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI25</accession>
    <name>A0A2S5BI25_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI25"/>
    <dbReference type="STRING" id="741276.A0A2S5BI25"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="44744" checksum="7630F48A743E3C0A" modified="2018-07-18" version="1">MAILGHQARWHIRKPQYGSRRLAAKNHLVAALGEYVGTCLFILFALGGTNIANLPTTTVTGSTQAGQDGSAAQTANTSNLLYIAFAFGISLTVTAWCFFRVSGGLFNPSITLGMLLVGALSPVRAAILAVVQILGAITGAAIIDALTPGTLNVRTKLTPGMSIARGLFLEATMTALLMLAILLLAAEKSRGTFMAPLPIGLALFVAELASVYWTGGSLNPARSFGPDVVLHTFEGYSWIYWLGPAIGSTVAAMFYRLIKYLEYETVQNNDDEGGEAVAPKGNDPKTASGAEDVEPKDGVPVEVTGFGGGLLQSQDAQPAAMANSGPLADPRDLSDKMDRLEGMMMAMMSRMNDGAAPPRSPDRISGETLAAMPAEKESHIVRTDMNDSQSAHAIPPNTLADHPAWVRRAVSSRRSASIDAGRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIL7</accession>
    <name>A0A2S5BIL7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIL7"/>
    <dbReference type="STRING" id="741276.A0A2S5BIL7"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="224"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="508"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="695" mass="77173" checksum="C02A8021514CE964" modified="2018-07-18" version="1">MNQVRSRFHARRRAEHEIRLAALAGTHGNYGLQTTAPLEAPGSQPPAGWTVPPSHDQANAANQGNATHVISTPDVPSTVPVVEPLPPRDDHPRKMQPFLQLMTSGASRTNPMLRYDTVVNGVWHGFAMLVSTDAGSDYSISPFLTYQWDGTAGGLAHVPIHELPRPGPDASEPGVETRSAQGIRYHVFNGLLGSHSFWRFKIEIPLGEREEEIFYSVNGGPENSFFVPARDQQFRAMYHSCNGFSSGVDQAAFNGPDPLWRDVLSKHAKQPIHVMVGGGDQLYCDPLTKEPEIAPWINETDVSKKIAAQLTPEMERALHRFFFNWYTHWFRSGAFGVATGKIPMLNMLDDHDMIDGFGSYPDDLQSSAVFSAIGAAGYKWFLIFQMFLSDDVDGNTYELATGVPAESAHVSKALIIGGPGAFMPYPNHSFLSYLGPKMYILMVDWRSERRFDQLASQTTYDRCERAIDALPPGVEHLVVLVGVPIAYPRMVALEQMLEKKLNPMTILAKVKLMPSGVNKFNAEAELKDDLADHPCSADHKKERNALVLRFQNLATRKHLRISFMSGDVHATANSQFKSTKKIAPEQDPKFMLQIISSAIVNTPPPPPVIWLVTKLGKKTHKTLHHADTDEELIPLFTEDTDGSKPKSTTVMGRRNYCMADYDVTTGEVQFTICVEKAQGSGTTKEYALRAPPPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIW2</accession>
    <name>A0A2S5BIW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIW2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="532" mass="57184" checksum="1EE2964C4A021677" modified="2018-07-18" version="1">MVSPRPQTFVPGSYWPPWAVRESFETAAWKHALQSGSDGVVKTGKHSIVLTCQSPLCPFLVKILKGDDTANTSEVELEHSHAMLDFADLNKASSEAKKVHKKCTAALYSAVEAFQTKAIAEIARYRLLADNEAMSTYLLPSKRTAFSPTTGQEGIFWEVADALGEQRARELESALRRDRRLTDFYPSVSTFDGKSSPFDAPPEQRFPPTPLAPAPEPTPSPTAVDPHQGKRKEKQEDRVAAQQKPKKSKLSASSAGKDDKARPSGDGAASSPESHKFAFAAYAASPDPLSAPKPKKKKKTLINFSGPSPFAKPTPTKRAKKKDEDAPLGLKTVPASTHSGIKPTAKLDTFDASRFFAKDGSPTPSRASAPSPTLLVKKEGFVDDAAAGKAAPKQEVAAPSPSLAWPSLASPAGTQSTAEHNNGDTIAAEAQMSPSANEVAADAASPPADEPADDLKAYLKALPNSTQFSFCDRYHEKLVDAQITTGQQLQVISQLVPEDLKQTLSLGKKDLVYAIFERALASQREEEAKLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ60</accession>
    <name>A0A2S5BJ60_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ60"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ60"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="326" mass="36431" checksum="5FC0F524622BD6F7" modified="2018-07-18" version="1">MDVSTILEQSNERHKAIAVNKEIPVEIDLGLLAAFDPNPIDLETYQSDKERALLEHARDGIQLLVNGIWSQRTRVVDEDVVADLPPIQTGLPREKPLPKPAPMTKWQAFATAKGIAPKPKKDRLVYDEEKQEYVPRWGYKGKNKDKEDQWIHEVPNNADPNFDPVAAARKERKARSLKNEGQRLQNLQRAAATAAKQTQETAGKHAQRDQRKREVEQVLKATKKSTASLGKFDDKLKGEGREKNIKRKFDANEVSASDERQKAMSILTSIGATPSNKRTRVSDDAPNARQESKGLVNERKAIKKLTGGKGALSLEQKKGGKKGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJD6</accession>
    <name>A0A2S5BJD6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJD6"/>
    <dbReference type="STRING" id="741276.A0A2S5BJD6"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="326" mass="34486" checksum="2575E4EA9DB2A1A6" modified="2018-07-18" version="1" fragment="single">AFEKRWAQDVVRAVLGTILFHRVVGGLQPTSLEVCGVTFSAPAAPDVEALIAARTDLICRALLEGVSTGANRRVKLFVTLYPTPLPALPPKNARSRKRSYTPGQRVPSPASAAAAQDASSSPSRGSGSRRASAAALAQAAPAAVTSALGWFSASARAAWVGGTQDDAVAAPANVPAGATLMGQDLLAAEQDAEIRMLDSLRDQGRKPFEGWMIEFEVLPEPVGVRGTQRPNGRDEKLRAQLNDFLLRTLDFTLTRSSHVPPITTTDLMPYGILVLVDPPTAPFDVPKPIIEPVKSFPDLHRSLASDSAGSAVPFDGRRAASVGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZP8</accession>
    <name>A0A2S5AZP8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000155">
        <property type="protein sequence ID" value="POY70006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZP8"/>
    <dbReference type="STRING" id="741276.A0A2S5AZP8"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="184" mass="19211" checksum="3EC72B900D67A770" modified="2018-07-18" version="1">MATQVIPGQPLSAPGASASLAAGPGTFTRGGQVYAALVGHVSREGGVLSVQGKDETQAIPEPNATVVGTVTRITRQAATLSLLTVDGRPCRPDFTGIIRSQDVRQTAKDSVKIWSCFRPGDVVRAKVISLGDSRSYFLSTAANSLGVLFAVSTSTGEPLEAVNWEEMRDPSTGEVEARKVAGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZX1</accession>
    <name>A0A2S5AZX1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000148">
        <property type="protein sequence ID" value="POY70076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZX1"/>
    <dbReference type="STRING" id="741276.A0A2S5AZX1"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="680"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="700"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="736"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="800"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="836"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="872"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="908"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="578"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1045" mass="110550" checksum="ABEED76844624660" modified="2018-07-18" version="1">MAKAYQVEGALPPRAKVGKRSLVVALSWGLLYASRNLTAGEVEARDRIMDTSNISPSVGGAIPARLGLPRRSSFDPLSSSTRKGLSLGALPGPSFGALPSGLRSVPALDSTRPFGSGAFRNVSAPVGDGQRTPGGSLVVGAEVFGFGKHAPRDSSEQRRRVATGGLSATGSASGSVDGFDDALSTTGSARLGGTPTGNGPAGGWARATTAPTADFARQTATSTDDLWLRSSADDARFRKGLDRLSADYAAAGGSSSLSGLRTSGSAYELRSASPVAFSDALRTSTRSNLLPPNVQVAHSDGTHHNMTRLESQPNGRDDSTPGAATPVLLDPTPAAAAPTSISPSVYAAAAEAISSPDSGPYTYPYQPPDPSPPPLGNPYFMAAMSPSPGPTYGDRPPPSAGMYASFGQASTASANATEEDLSYAMRGMNLASGAGAGAGGATLPNGGLQRGQQYSPEPYGAGGRREMPARQDSATTFQPYYIAAASPYMAHVGDMYASAGYAPAGPAYYVAAAGDPNGNEAGTNAGAGGPPNNIRRDSITPQWGLPMPPFALPTEFMGQHSRQGSFSCASPAIMHVQAYPQGSAGPPPPPTSTFGGANSALGPAQTQGQQGSNGGGDENGAGTGSSAPYHSQPQHPGGPPIGQQHQIILGRGVRGQEYVAPGPMAHHGYGMGYAPDLRQLKSPLLQEFRNNRNRSWELQDLQGYIVEFSGDQLGSRHIQTKLDSATLEEKAMVFGEILPNMLQLSTDLFANYVIQKFFEQGSQVQKTAMAKLSLQMYGCRVVQKALEYVLVDQQIRLVKELDGHVLKCARDAQSNHVIQRALERVPPDHLVFITDACKGEVRDLATHPYGCRVLQRIFENCPPPQTRPLLDELMRHVQDLVEDQYGNYVIQWVIEKGDAADRSCVVARLYGQVLPLAQQKFASNVVEKCIVHASEDERRRLIEEVLKANPDGSSIIKAMLTHPFANYVMQKCLACAKGPQRDALFDETAKQLTILRRYQPTPSKHLMAIEKVLASERERKGLPPLQFPSAPGQPLSNGHPMVVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B044</accession>
    <name>A0A2S5B044_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000153">
        <property type="protein sequence ID" value="POY70031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B044"/>
    <dbReference type="STRING" id="741276.A0A2S5B044"/>
    <dbReference type="OrthoDB" id="2521467at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015477884" evidence="1">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="193" mass="20869" checksum="1C354E3D5893C493" modified="2018-07-18" version="1">MLFKNILLPLSALAATAFGTPVALEKRNGTSTDMNGPTPPQLKWLYTANVLCPANLLPALLTPAGIRKEIPIIGGNFSGPGINGKFRDLGADWGTTDPRTGIFTADTRYNGVTDDGADLFFQTSGPKSPDGSLHLRIKIETGSEKYYFLNNVVAVGVLRNLGQDSKNVSTLRIDAFNFENDWSNTTFLNSTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0D4</accession>
    <name>A0A2S5B0D4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0D4"/>
    <dbReference type="OrthoDB" id="2537600at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="645" mass="69077" checksum="4419AD15EBB59029" modified="2018-07-18" version="1">MATARVHDATEDGDELLFGDFCFSCGNATQGGPYCSPECRKADLERSEASPDDSPFMSSIPPLISSAKSACSTPPSSAANSPDNVDSALELGEPPSLDLPPPKHGLEFGGQSLPHGLRFPSTWTINYQPDLLHSPVVQPSEVAPTKDLNYRRKPGKPHSVVPSPLYFRQKAAARHGSPSFGATCALNPSMSGMPVSTDISGAHVHEDDIASLDLPGQRHADSVSHLLPKPANCGRAGCIGVPKRPKLEQQRSSSRRISGSMSPAHRALAPLDTSEDLLLSPRIRNLRSHYSPTESREASPSPLLGPSEPSPSPTKATDDEHSAFACYLFSHLSTEAPPEQERGRTTAVNPSSADVLRSRSVDTVLAARNAVQSSAHTASPAPTPTRPRGMMGGRNGAFNARSDPILETVADSRTGARSPGRSVDPDEKTLFSSNGAELDRDATLRASNQRGRDRHRMQLTPGHFISATTETPSGVSPFPSPPPSPPTAGRGRSVTRRMSDAEPVAASVDPRGRSKMRGSGAVQRSQSPSARSDSQSPSRSRSRSRNQTRSPSRGRVNGLRETRSSRESSNASGGGRRGRTRERGDREPSPVAPVVNGLTRRDGWSTASEDDEEDAPVERGRGRGRSRQRDSRSRSASKYRRANHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0F1</accession>
    <name>A0A2S5B0F1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0F1"/>
    <dbReference type="STRING" id="741276.A0A2S5B0F1"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="43289" checksum="3FBE0F70A7F640A4" modified="2018-07-18" version="1">MPRGRTLLYVLVAFFCGWFLVVHPRLPRGYFAYSTRPLWDTNEAPNEVIRQYRAPELALRDHCALHDWSPRQGNTTQVWDATIWSTETDLYLTRLHELDPVVDRFFVLESDRTFTGLEKPLVLGDLLRSDERFAPFRRKIEYRTFKGRMLEKGESPFAQEGQMRTAMTDLLRENLAAFDGPPPVLLFSDVDEIPSRQTAALLQACAFDAPLHLGLKSYLYSFEFEEGGETASWRAKAVQWPERGNGPNEFYNHGKVSERILANSGWHCSWCFRHISEFRTKAEGYSHVDRLGSRPTALLRPKRIQKTICSGLDFFGMLPEAYTYRDLVDRLRIRPKQSAVDIPSYVVKHREELRYLLPGPGNCIREDAPKSFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0H1</accession>
    <name>A0A2S5B0H1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferrochelatase</fullName>
            <ecNumber evidence="7">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000134">
        <property type="protein sequence ID" value="POY70282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0H1"/>
    <dbReference type="STRING" id="741276.A0A2S5B0H1"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000001">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="420" mass="46156" checksum="712692910D155804" modified="2018-07-18" version="1">MCSLPAIIAHSYRHDEHGRPGKGESARSETWARSWPLSSLPALTPDSERIQQSAQTHDFLRRLFADPDLIPLPFQSTLGPLIAKRRYPKIEKQYDAIGGGSPILKWTRIQGKGMAELLDELSPETAPHKAYTMFRYAEPLTETCLDEMRRDGVTRAVAFTQYPQYSCSTTGSNLNELWKQIPGRAGLAKQKGKEVTVGADPVDEIEWSVIDRWGVHPGFIDAVARNIEASLASYPAESRDGVVILFSAHSLPMSVVNRGDPYPAEVAASVSAIMARLGNRNPYRLVWQSQVGPSAWLGPQTSDAIKGYAKKGLNDLLLVPVAFTSDHIETLFELDLEYLEEAKELGMTGVKRAESLNDSPYFIRAIADIAAAHLKSGQAVSPQLGLRCPGCTNEKCGHQKEWLKSFQAEIASKSALASAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0H3</accession>
    <name>A0A2S5B0H3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.35</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0H3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0H3"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="6">
        <location>
            <begin position="141"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="439" mass="47830" checksum="240E86EB1DC7C34D" modified="2018-07-18" version="1">MDSIPSPINAGMRYSPRNPTSRIRDPSQAGSVRSIGSGTVGRDGQVMYGVGGHGDEVPIELLQSVYLSSNAMSPNPDTGAFPMPASPQPESVAPVHHRSHSLSSDRFSPNSVLDWPSAVSFTTRTTYPPVRRLARAQKKRILVTGGAGFVGSHLVDRLMFLGHDVVVLDNFFSGSKCTLSHWVGHPNFELVRGDVVEPLLIEVDQIYHLACPASPKAYQLNAVKTLKTSFIGTQNMLGLAKRTKARFLLSSTCYDEGKRVAEALTYGYARQDGVDVRVARIFNCFGPRMSLDDGRLVSNFAVAALKGEPLQIYGDGQATRSLMFVHDLITGLIALMDSSYSEGPVNIGTVDEGTVLSWAEEILSLVKELRAAGSIAPLPLGQLESTIEFVPAVVDDPPRRKPDISRAKEQLGWEPKWPVRAGLEETILYFARQLEEGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0Y2</accession>
    <name>A0A2S5B0Y2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0Y2"/>
    <dbReference type="STRING" id="741276.A0A2S5B0Y2"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="84" mass="9058" checksum="C1E1AAA5E7DC39D3" modified="2018-07-18" version="1">MQNDQGQVVDLYVPRKCSATNRLITAKDHASVQINIAEVDESGKMTGSNVTYAFSGAVRETGDADESLNRLSTADGLLKGVWQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1F1</accession>
    <name>A0A2S5B1F1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1F1"/>
    <dbReference type="STRING" id="741276.A0A2S5B1F1"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="726"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="989" mass="107135" checksum="8F3A873AA2774AFC" modified="2018-07-18" version="1">MAARNGTASGLAATRPASVASSSGAASDSNSRPLASDGPIASTSKSATAVPAPNVGDKLAVLLTTLSAQDDESILSIAVEEARESRDDHRLGTSVNPSGVGIGSRDGKRQTGRVYGGSQGGDIHVWDLATLSLRSRLTGHDGAVLALQLIPERDWLVSASGDGTVRVWHTPTLSLVYLIHPPHDNIGDILSLAWVPYNLLDKADSDRRPNGAAARVRKPAGRLYAGCQDTSIQWIDLPPPFQLSAEDVAPVSHGGRMSPVSGSPHSPPIFKTPNRFFDSLTEADRARTRIGLSASSSGRHSLNTSNAATPLASSPVGSAPKTSPPIAHAQEAGPIRTQFEPNSVELQFQAECIAPFAHNGYVYCLSLAKCNEQTVLVSGSGDETVNIWRPGVDALSLLSTLESEYDAVLAFAARDNTLFAGHQGGVIKVWDLDSLTCVRILRPHKHDILALSVIASSLFSSSANGSVQRWDLRTFRLAGEWKAHDNIVLASDVRTLRRSRTQGWLLTGGNDATVKIWDVRDEDVTSPLSPLDRGFQGELFHTLAKFVSYRTIADTEHREECRQGALYLKRVFREMGAETHLLPGAAERNPIVLATFKANAPPRPDTPRRRKRVLYYGHYDVVSATASERWTHDPWKMSGQNGWLYGRGVTDNKGPILAVAAAASDLRRRQELEVDLVMTIEGEEETGSAGFQEAIRSHRDIIGDIDVVLVSNSYWIGEDWPCLTFGLRGVIHATLKVQSSRENLHSGIWGGATSEPLTDLVRVIASLTAPDGSVQIPGFLADVRKLTSQEKLLYETIVQRCQGADTLKKLTSGSIISDPVQSLITRWRQPALSVHKVEVVGPAQKSLIPSAASAAVSVRIVPDQSLEAMIDKLTKHLEAAFATLRTENKLTIDITQTADWWLGDLESPYAQAMAKSISAQWHLDPLFIREGGSVPSLPFLEQEFGAVAVHFPIGTSSDNAHLPNERIRVLNLEHGQTIVSKWLTRIAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1X8</accession>
    <name>A0A2S5B1X8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_6200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1X8"/>
    <dbReference type="STRING" id="741276.A0A2S5B1X8"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000287">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="246"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY70788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="510" mass="56450" checksum="B6BAD6020258AFAA" modified="2018-07-18" version="1">MSVLFETSVGDIIVDLETEQCPILSLNFLKLCKAYKYNFCSFHNVIQDFIAQTGDPTDSGKGGASIFHQLPADSPAYQKTPYFVPDANLKLKHTAYGTLSMAVAGEGDQRGCGSQFFLTLAENLDYLDGKHAPFGRVIEGQEALAKINEALTDQEGRPLRDIRIRHVIVLDDPFDDPPGFDAPEQSPVPTAKQLASLRVGDEEDLEEDGDPEELERKRRERDARAQALTLEMVGDLPFADVAPPENVLFVCKLNAVTTSEDLELIFSRFGEILSCEIIKDQKTGDSLQYAFIEFRNREDAERAYLKMDNVLVDDRRIHVDFSQSVSKLHDTWVYNRTGGRAPPNKSNRGPPSSSRNHSPPSARSGGGRGGGGGGGGGGGRDRDYSSSRYSHRVEGAHGEMVFDLAEVDERARERKSSYRERDRDRDRGYGGGRGGGNGSWQPEDDRRRDGGRSGSGGASGTSRYPDEGRDRETRRYEGGGSTSSGRRDAGRRRSRSPDPTRRDPRDSRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B238</accession>
    <name>A0A2S5B238_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B238"/>
    <dbReference type="STRING" id="741276.A0A2S5B238"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="744"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="781"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="837" mass="87760" checksum="908FE7A4B35DEC32" modified="2018-07-18" version="1">MSTALLEHVLANQLAQNELVPANASQVADLLQQQRVIALAEQEEGLHGPVLHRWQLRLSSLVSASNAPDIRAAGFRLFLVTFASSTTLVLAAGKNALSSAQSAMTSPKTPPSLFLAALDLARYILAKSTWHPEWARENVGAQTVQKVVSRVVEVASSPDGSELALPCIATIVSLIPLFPTALRPLAPSFHNLAISLLADGSSPALSDAGAQLFVSLYLLAPKGKDGLREAWKTGVEALVGSVNQLATHVVGGIFAEDITYNHGLSPLAMPALPTPDAHLALSRLETLNRVLLLALRTPTTEKAGPVAVPLGALLELGVRLAAFSTATPVKERTDPTLRTATYALLPRLQIQGCQLLAQLALATTSQLATHATTILSTLAKTLTTYDVRSPMRPAISTAYAIVLQGLGAAVDPEEGKKSLARVWRTVLEDIGAVALEPLVISQSTGESKTGGAGGSGSGGNSRRAKRQRMYDPSESMAQRRVALDDGDLEIARRGLQTLERLVRCPHAHFLPPALQLATSRMLLYLSLSPSFFLTHPLASTSTSFFPSTSANHALDIARQSPAFRRAVVSALQALLEQSFGGSGLEEKAVEVWRRAANDSDDHVRLVALRGLAHFGSVIHPIVPPQQPNSAYTRIRHEQKGGFVGDEEDFAETAEVFRLRVVPEREAIDDEDERMETEERVAAAAAAEEDERKRKLTAAPAAAPSFASSAPTSFSASSFAPPPAAAAVAASGASSFAALATPAFGSSALSTSPAGADKLGGSAPQATGSFAPVDVVAPSSFIESSTTARAASNTAHDSAAGGQSASEATTALRGEAGDDDDSDDDEMPAIDLGGSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2A5</accession>
    <name>A0A2S5B2A5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2A5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="514" mass="56731" checksum="CD333E91D790D29D" modified="2018-07-18" version="1">MFDFFVDWTNRVLVCYYWPLPPPEIEPFSDCFICSVISFFQILGYWSLFIGWVIWFLFGVFVRWIPTLIVFVNLCQLVARSETWFPRFMPEPDLIIYGDDNEDADDTYSNPPERFFAASLQSMPVTPTRSVLSPTSLSTPPSSASSCRSSAPSSPASSSAGSFSSASSASSEKAPTILTSAYLIKIVAMAKFIQAQGKVLDTDEKRAGAFAYGLSIIKAEETRERAYDAGRARGGIDYQESDDVRHARMKARIESHLYTYILSLRPTPQPSPFRLSFRPMQSSPKLAGFERSALPEPITSRTESAAEPFQSLATLRAAAKRPPTGVRFHRSPSQASQSQIAASRVGRDFDRLRHAAILAAARKRVRSDRGAMPVIAAPTLEHHPESLPEQAAASEPSSKRWADYDESDDDAFFAIPPDFGDEPIVAAVIAEQPAGPAAISEELQWSELVDLPDDDYFATPPVFGDEDKVQVVAFEEPASPAAPAPLRWSDLVDLPPDDDDQYFASPPVFLIADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2K9</accession>
    <name>A0A2S5B2K9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2K9"/>
    <dbReference type="STRING" id="741276.A0A2S5B2K9"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="200" mass="21283" checksum="C0B386949EC6F29E" modified="2018-07-18" version="1">MSSSDLIDGLPVFTRTNDSSEAASRSASDCLLSLTSVRPLTRFLLLLIPVLGSALRPAPVGDGPTTGFFRNNYCDASPHDPGSHTVAAVVTPTFLDFSKSRGNDLWPLFPELKKQAAASPSPQDPTGATPCVWCLCASRWYEAVKAAASHPLGDKIVPRVVLEATHERALSDGKFTKDEIGKFAADVRQADPAKGTTTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2L4</accession>
    <name>A0A2S5B2L4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2L4"/>
    <dbReference type="STRING" id="741276.A0A2S5B2L4"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="444" mass="47797" checksum="8D359D4483353611" modified="2018-07-18" version="1">MVTTRSHDHDNEAHASGEAASGPASTSSAKGPAAAAHAGDKRTASEQHEEGDDEASAHEHKEGGGGVIKKHKSSHERKVVVMPDDSNKGGDDQADGGQHKLTTTSEEGKQEEGQDVKEEEATPAAGAATEPAKVEGESSGKEGATTGGGEGNAEEGQVPQHEPNPDPKRKHGILEKGHVYFLYRPKVEVEHPESLDDISKFHILLVPHQTKFHRLIAVGKKALPEASESTRPIWGEVLNVGEDLNALKEGLGSYTYETKTLGTRHQPGARVAGSGAYVLHAAENYPKDSANASAVYHTYLVYELAVPHQLGEVQHALHIHEEGGFTLQVKNPEAPSTNPAVRNKPESKQPKYPEELHKLFKTRFIPADPPALLDYPGAELLLIPSKHTPEQDTSRKAKEALDSEEKELESEINKQSNGGEAKKALKEMGLDGLIDGKALEGHWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2M1</accession>
    <name>A0A2S5B2M1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2M1"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33743" checksum="12EFC1030BDABE8B" modified="2018-07-18" version="1">MPRPRERSNSPDAVDIFADSLESLYDHHVPAHGDPLQLYTYIPPADATCAYGGFTVRLPPQQVNELFAHHVWNSSLRLADGIALDRVRVRDETVLELGSGAGISGLMAARAGGAKRVILSDYDDPKIVSNLRENVAMALKDCPEIRTRVAAFGHTWGEADSMQQLLRANSSQRFTTILLADTLWMSSGHDALLSSLSQSLAHSASAQVVVCAGFHSGRATVRSFLRKAARIGLVCKGAWQELGVDGRRRPWGWDRPDPARQTDGSALVDNLDAPDEWDELEDASERNRWVVEGTLGWSDEAFASDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2N5</accession>
    <name>A0A2S5B2N5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2N5"/>
    <dbReference type="STRING" id="741276.A0A2S5B2N5"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="191"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="342" mass="38333" checksum="CD4340D0000FDB02" modified="2018-07-18" version="1">MPSALNTFDLSAFLAETSSVEEQTQLAKAFVEAASTVGFFYVTGWQSVIPQELVDEVFVQRAILIDTSHLRQNERFFNLPLEKKDALAYTSSKANRGYLAFGREQASLSKHADQIEAEREANKDQKETFEIGNDSDPQYPEHWPAEDDLPGFRETMNRFHRLCDRLHLRLMSLLALSLSLPADFFTSRIDGRNHCLRLLHYPPVPRQGSQNRIGSHTDFGTTTLLWQDETGGLEIEAPDGSYVPVTPKEGTLIVNFGDVLARWSNDKLKSTVHRAVLPPPQEGEDENGMTRTRRSVAYFCNPNPDAVIECIPGLEGPDGKAKYEPVLAGEFYAKMLEAEIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2P0</accession>
    <name>A0A2S5B2P0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A/B superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2P0"/>
    <dbReference type="STRING" id="741276.A0A2S5B2P0"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="292" mass="32768" checksum="D03A92053735D6EA" modified="2018-07-18" version="1">MPFVDLPALNLRQYYAINPTYSADADPSIKGDPPPSDERIDDAKPTLVFCHAGTSSSHSFIEVFNLVGFDTRYYGYTQGPRERADELLVAIDAVLGERRFSFVGESFVGSHIGVYVTAKRPRQVKSLILLSPSWPQDPPEFAATLSAEWMPLCAANKDGKGDGSGAIPEDAMAITEHFPERQKNFLKRYQEGHGPGEDMFKLEQLIHWFQRPLPSDDVFAAVRCPVLLLGGTRDQTVSSSDALQAWYDLLRNVPEDDRRIERIVDGPHLLALLESNRVNRFILAFLKRYELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Q9</accession>
    <name>A0A2S5B2Q9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Q9"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Q9"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="12">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="477" mass="52287" checksum="466EB9C0251D4586" modified="2018-07-18" version="1">MAGFRMLDLVRPFLPLIPEVSAPDRKIPFNTKVGWTAITLLVFLVCSQIPLYGIVSSDSSDPLYWMRVILASNRGTLMELGITPIITSGMIIQLLQGAGFIEVDFTLKEDRALFGAAQKLLALIISFGQATVYVLTGLYGQPSDLGAGVCLLLILQLIVAALIVILLDELLQKGYGLGSGINLFIATNICESIVWKAFSPTTVNTGRGPEFEGALIALFHLLFTWNDKSRALKEAFYRERLPNVMNLVATVAVFALVIYLQGFRIEIPVKSNRFRGQRGTYPVKLFYTSNMPIMLESALTSNVFIVSQMLFNRFPENLLVRLIGVWEPLEDSAQLFARSGLVYYMSPPRTLREVVADPIHTAIYIAFMLSACALFSKTWIEISGSSPRDVAKQLKDQQMVIAGHREGSMYKELKRVIPTAAIFGGAVIGLLSVTADLVGALGSGTGILLCVTIIYGFFEMAVKESTPGMEAFGDLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2V0</accession>
    <name>A0A2S5B2V0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2V0"/>
    <dbReference type="STRING" id="741276.A0A2S5B2V0"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="592" mass="65459" checksum="FFAF92166060614C" modified="2018-07-18" version="1">MPRPRGSRRSAFANSATFAGDQRDAVGPPSALLPTATAFAEQVEASLKAAEAELNLIKEDWAKWTPEQTARLNERCSADAFRAANAELRDNQLVQPDIKNWTESRWYPNKDDTVDDDGPDQTTVPGRKQDREYRMVTPDFGEDVQLIGDDEMQRAAQEAGASKLNLLQSPPVISYLRKLRTADTNALLAMRATEDDDPLPSFPPPDDPQAKVLYTITFQPVPHGPGVHHVPQQKLVCLGTTTLTEIRDNLLVGGDNIPIEETDREGSVAGVDSDGEANGSDTDEGDEDGFGYRGPDRRPSEEYFGGGETKTAEPRAPKWKNERRTTGAAFVVEDWIYADTREGMQDYASILLDTIDKTKWPGDTDGSEQRDGSEDLALTPLDLLPSAVSAAKAGQAGSETNPEPLRPHRGKPRLRRGKAAQFVTLGEMPLRVGQPYLFVHQGDDEHIWSLEEVRALHPSDPSPWPPADAHKRSQAYQQFRHPYPITTYLSRQANMTLSNARCPLCEREPPDLALFDDALTGETPSHVCRACFGTLHPVKRDWEAEARAAAARKAPGRPKKLPTPPPVGYEDVADDEREHMDGVRTVPILFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2V1</accession>
    <name>A0A2S5B2V1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_5864</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2V1"/>
    <dbReference type="STRING" id="741276.A0A2S5B2V1"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="15">
        <location>
            <begin position="38"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY71107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="443" mass="48030" checksum="E411B999FCD822EC" modified="2018-07-18" version="1">MFSLLSRPLRASATSPLLRRSLATVVSPKSTNPFNRDLPATLHLKTGESFTGRSFGAPVSRFGESVFSTSITSYTESMTDPSYRSQFLVFTTPLVGNYGVPDNLNPANHEPNGPPVMLESNGIQCAGVIVADVAEKYSHYQAVESLHEWCDRHGVPGITGVDTRAITTLLRTNGSTLSKLSVGDGHLERPADNEYWNPATENLVDQVSTREVYTLNPDGDVKIALLDFGAKANILRSLVRRGASVTVFPWDFDINTVRDQFDGLFLSNGPGDPKHCMKAVEHVRQCIDEWNKPIFGICMGHQIIGLAAGYDAYRMRFGNRGHNQPVLALASTGNVKAGRVYVTSQNHQYALELCDPSPKDFEPMFINANDASVEGVKSTLQSGKRVWGVQFHPESAGGPLDTVFMFSDFVAACRGTAGGANATAATGDMAKGTFKKTDFEAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Y6</accession>
    <name>A0A2S5B2Y6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Y6"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Y6"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="289" mass="30972" checksum="0C8AFEAD9A22479A" modified="2018-07-18" version="1">MLDLSFPTSLDGFTRSISVILTSEIGDRTFLIAAILSMHHPRVTIFAAALSALGVMSFLSALLGNILPGLLPKQYTTAAAAVLFFVFGAKMLREGLEMEGGEAGREKMEEEMREVQKEVQEAEEEVTGRPGGMGLDDMEEGRSMLRGSPASTEEGLPTPAVSGTSSHVHRGRQAKDALNSVSEGIKNLAQLLFSPIFIQAFVLTFLAEWGDRSQITTIALGAAHNVWIVTLGTTLGHSVCTGGAVLGGRWISQHISIKHVTLGGAVLFLIFGVMYSYEAIYFVDDVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B365</accession>
    <name>A0A2S5B365_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B365"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="902"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1008"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1400"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1118"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1521" mass="166710" checksum="4D334E3AD5577D14" modified="2018-07-18" version="1">MTDSTGSEERPGGDSVSNPPPRPSRPTYAQLAGAKADSVMRDPAAPPVPPKKPPVMQTESVTTSAFFTSSAAAASTSQQRPSGPATSPASGFRPAGSSYSQVVSRRKSSPDSAQIPPDHDSDSDDELRLAGNEGYAGPAGSSPTLTKKVHRYTYGKNKRPPSSRERSTSGTAATAEWDPDNWGTDAPQTRPAVATTSAVRMEPRGWETTSGDARWEQQVESAYGQQHGMQRRTSRSSHRQPGQPSDHEVIVVRDESPVGYAADFGWWTTPRLLAKAGENGSRPGLWPHTAYDVEVADTPEGTTSTCGKPYPAMGTEIPGRETTTPSQTDSVMTDALSDTGVTTSGAGLPDDPIEDPDKLPAEAPPKPSKAKFRTVTREELDKCRPHPALMFCPETFTWGFFDVVKDGGPTPPREPVLWHLASRDVPRGGLAQLFKHHFPHAPLPDPLPPAKADSDTVSSLEQLPRGHVFEIESTAGRVCLVTTQDWYPAVIPASLFADLLRQRRANPAVGQPAAEAGFQTIRFMWRSLDNYLFVGERRGLTLDGKTFREKIVWDALTKRIFFDILGATVLDGGLVYENEAQSAAEREICRVRLLRCWLELAIWLDHTAKIHGGQNKVDTRIRSRSAKVHMEKALGGDELPRVPASDSWTVAGENRVAIPGSDVPLDPLAVEYDALGVTPDLADEVIVSAYDKLVEKMPWRQPVYLEALVKIANVRGTEDVRVKVATERSIGRHTAPEIAAAYKELRLPDPCDPATPYISEDTLVEALQTRLAEVEHPDRRTVLLHSARTISSFAKSEFFDALLESSGAGIAGDDGKPKMDVDAALRILGMESAPDDDLLIQIYDIRVSDATNVAEKVKAKDALRVIAEARQSATLRNYLKTGEKSDDAGWQAALAVNPQIPVGLTNIANTCYLNSLLQYFFSIREMRETILAFEDNGEASTDGHQLPIRVGPREATPAEIKRSKRFVVLLKTLFEQLIHAPVSAVTPETELAYLALVPSEQEILASASTAEPAALTSEPEAMKTDLSDRASPAASSETVKSPSSVLGKRKSDESEDDAMQPEVLLPPGEKPAEPMVERDAPAATVSTEAGSDVDHERPRMKRGRSAEHAARDDTTPKSAPPPLPPRPAAAVDDRKTELERQVSTYMSFGRQNDVTECMDNVIFQVETALLANSTNGRGAATANLLRRIFYGTMRQKIMFDDPNAIDDPLRKRDEPFSAVFVDVPAVKGTPAPGLTRDIYDALDTVFEPSQVELEGHSARRHIQLVSPPPTVLQIQLQRVQYDVVRQAAYKSNAHLAFDDEIDIGRYLEAEAARSEDEMRRVRTFEASEELKSVRARLSALTSDGVDTAALLTSAAKYGRHVKQHARGTNAKATGDEDMAVEGSLAARAAALKVHMIDSLFDETEQEASAVQDEITALNHRVGELKREMRELWAEGGLERQSRYKLTAVFIHRGTATSGHYFIYQRDPRDEKRWFKYNDSVVTEVDADEIFRETTGDTNPYFLSYVRMDCLDAIETIKREIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B374</accession>
    <name>A0A2S5B374_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="11" type="ORF">BMF94_5546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B374"/>
    <dbReference type="STRING" id="741276.A0A2S5B374"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="72"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="10">
        <location>
            <begin position="152"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="570" mass="59600" checksum="71455F83B1E2B33A" modified="2018-07-18" version="1">MHAPSAPAPSGQAPAALSLPVPPSAFSSGSTTRAGTSLRVAARTSTALARPGADVQTAVVLAVLFLRYVVFEDPDISKRINEERRQKRKRARSRSLAGDGLEALRTAEAKRLAGKDRKGKGKGSTNGSEATAAVTNASTLLDSLAYDLASHAPESLDWLNVLLGQLIGSYRHLAAAHSDGGARTLLEEALNRSTLAAEAEGKQPAQGMVGLDFIEVDEVELGDAFPVLTDARVRPSGMDSESVRVELDVDYSDRVVLAVSTRVVLNFPRPRFAILPVSLSVALERFSGTLTVEIPPQALAASSDRATRTSSTHPTIHLSLHPDFDLSLATSSLLGSRAKLQDVPKVEQLLVARIRAAIQDRVVWPGRVEVALPSLERRNHHHSHHHRPSAPDDANPAAPNPDFLASDAETMTSPLSPLSASDEHFSSTPPPDGEGTEETPSGRTGRPRFPLRPSYLSASTSGSTTPETPSISLSEAGGPSIALHPKIHPPTPGGLALTAELLAAASSAAPTPSPTETLPGYFASKLGRSALSPQLPAHVAAAERGKTTGRAGGTGNARHRAKGGGGLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B376</accession>
    <name>A0A2S5B376_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B376"/>
    <dbReference type="STRING" id="741276.A0A2S5B376"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="104"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="440" mass="46909" checksum="8FDC1D95F6DAE33B" modified="2018-07-18" version="1">MEKSDPAKSTALPAMASCCWVRMVYSRGSVDLPCCLQVVRVHSSCVECGDGCAEVIEAGVRKRRSAESETQRRAGTRVASPSPSSQTVSYRAATMKAVVVPSKGQTELKDVPTPEPAAGQVVVKTLAIALNPTDWKHRDFLAPPGSWLGCDFSGTVDKVGDGVDNLKQGDRVAGFVHGGQWEGEGSFAEYVKAEANLVWRVPDSLSDEQAAAAGGVGPWTAIQALYMRLGLATPSSPSKEGEPVLIWGGSTSVGLYALQFLKAGGYTPVSVSSKKSYDLVKKFGAAATFDYNDPEVSAKIAKEFPSLQYGLDCISEGKTTVSIVKAIKGAKGTGRVITLLLNKDSEIKDVAGDNIKVEMTLAYTTLGVEFDWPGMTFPAMPEHKSRMEDWCAKGLPQVFESGAVKPNPIHSMSGGLENITEGLEYVKAGKNRGVKVTYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3A5</accession>
    <name>A0A2S5B3A5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3A5"/>
    <dbReference type="STRING" id="741276.A0A2S5B3A5"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17372" checksum="8EF039F98CA0484F" modified="2018-07-18" version="1">MSLVVPEAHVQFQHILRLLNTNVDGKRKIMYALTEIKGVGRRYANLVCKKADVDLAKRAGELNPDELERIVTIMQNPGQFKIPSWFVNRQRDIVDGKSGHLLSNQLDSKMREDLERPRHVKSWEAETCRKQSRRSATIADCEPTGAFVSVAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B443</accession>
    <name>A0A2S5B443_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000081">
        <property type="protein sequence ID" value="POY71547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B443"/>
    <dbReference type="STRING" id="741276.A0A2S5B443"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38698" checksum="AE72FD21A9587AA3" modified="2018-07-18" version="1" fragment="single">KARPAFDALPLRPEHPYASAWGLYGDEDEAGTLNALGPELVCQGLSEIRTARVFSLALPLTVPRTPMNPARRPPKHDLICKGHANDDTLTLNTQASSHWDGLRHYPYQQSGLFYNGTTQASISRASSTQLGVQNLAERPIVTSAVLIDFARYASAHGISYSAFTARRVTLVELELALRAQNAHVRSGDVLLIRFGWTEQYLGLSPTEQEALGNRTGDERAHVGVDARTDQIARWIWDEGVIAVASDTNAFEAQPFARFGPSPRRPSAVTDSPHRVESLRTDEDGGATAPASGAQSKERVAMHEVLLSGWGMPIGELWDLEGVADECARTGRYRFCLSSAPINLPGGVATPPNAIAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4B6</accession>
    <name>A0A2S5B4B6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4B6"/>
    <dbReference type="STRING" id="741276.A0A2S5B4B6"/>
    <dbReference type="OrthoDB" id="2526683at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015441883" description="C2H2-type domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="698" mass="73524" checksum="41B7ED4FDCD26455" modified="2018-07-18" version="1">MTRLTSLATAAVACLAASTFTGTVSAQSSTSGASASSTVAGGGSSTGGTVTMTSGAVSSAATAASAANGTRGAEPLVTVEGTVPAYANGTQASLTATIEAVWSTHFARGALTQGLTTLLSADNQTVYGVVLEFNETTANLNYSSTLVPWIATISCDSPIQSYTLPESEYSGNGSMMASANGTAGGNETVTMDLLQQAQDLGAKAILMYSSRSQSCTLNSTSLSSNSSGAATTGSNSSTSVTIPVFSTASQNVANIILQQFMNVAGGHRYFNSTLLTASTSNLTQALEAATQSGRLSGALNSVTTDYLLARINPTYNASDSSNGVVATIGRAPSLSASSTSQPAATGTASQIPLPEMRDPRLSLLPEPGHGRHSHFQHDDDQYADMPPLIGGPSMSAASRVLYQGTTDRDAASRFAAAIASSSSTSAMADSRQTRWTAEQEILQRSFERVHVHRNDLLQLPYPTPPVTAPLPPPSAVPIHRVYTLRCATCDTFLSDRGMRAVLLLKPHIILFSTDSAPANSTTFWPDDISQDQVERTCECLTSSINCHGCGKTVGYNIVSPCSKCNASVQKHQRSANHHRFVFHHNEVTARERTYYPGEPGVSNPIVRVQPSLSISREGSRSSTPLARTREADALEKDGPLRSSRVRTVSPAPRARDRGLRLLKAGDTVYWHMLVAGGERCPSVDPKMRVPVWKENEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4H9</accession>
    <name>A0A2S5B4H9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4H9"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="269" mass="29859" checksum="DB7D95E0E7037266" modified="2018-07-18" version="1">MDALGAPQFRKITFRGPPGLYRWTLRVRLDASLTLKLNLVPPIGVVVKQADLAALENKMIYTEWPTAVLRRLVHHILTSKTLRKSLKMMPDDVFGLYEVIKDSITNQGLQAASISRVKDGRTFLLLHDLKDIGLGTTKATLSKNPGQGLYELARQAAVLENRPPPVYISATAPYPVYDSDGRLIRARLREALTGGTAASPGENSGWAVWQRFERITRTGMTEEEKQKLAEEKAKRAKSVKEAQERKKAARKAAPKAIRGDADESEISDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4S1</accession>
    <name>A0A2S5B4S1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5096</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4S1"/>
    <dbReference type="STRING" id="741276.A0A2S5B4S1"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="125" mass="13276" checksum="C40FF102FD711D9F" modified="2018-07-18" version="1">MSGKGKAASGNTSGSTSRSARAGLQFPVGRIDRLIRKGRFAQRVGAGAPVYLAAVLEYLVAEILELAGNAARDNKKQRIIPRHIQLAVRNDEELDRLLGHGGVLPNIHSSLLPKKGPKKGSSGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4V9</accession>
    <name>A0A2S5B4V9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4V9"/>
    <dbReference type="STRING" id="741276.A0A2S5B4V9"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000094">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="82619" checksum="5E7C50977B88E9FB" modified="2018-07-18" version="1">MPSMLRVQAPPPSNVGDLVPALTPHAVSVALPKWQDNVDYEEGAERITKAMTSGYPRFFIHHQIQQLADLATSRFSREPQSDDGDKEACILLPTETTAKSCSAFLSSRSPPVDSRIVSWAIEATTPPPATAADPPVGKRVITIWACFFRAADFSAAKQYWQHTGEGISSRVAERCLVLLGEIEASDATTVASVAPAVAPPTIGEGQTDATHFFVPEAASSANHKGSAAAARYGNKGGRYQVAKGSSSAAAVTANGSGAETSARPAGLASKARYSTVKVPRRGSADASSSSTPEASNSLANSVDQLPLPPVLPTANGNGVHLVEQDEDVLARYVEERYGRNLDLSLAPLAKLAMRRRIAGVLSEQPGEEMTAQEVKQKGKQVEQQESSRGVKELTEDDVWLYPCGMNAIFHAHQLAMDAWQRQGKDVGKSVCFGFPYTDTLKILEKWGPGCHFFGRGLTSDLPALRELLEAASTPILALFCEFPSNPLLRSPPLHELRKLADEFGFLIVVDETIAGFVNVETLPPADIVVSSLTKVFSGDSNVMGGSLVLNPKAPHYAALKAAQEARYEDAYFDEDAIYMERNSRDFQARVAQENSNAEMLCDYFRSRRAPGPPAVGIVPPPAGEQTPADADEFVVTEVYYPKYQTPEQYLAAARPPPVGSSEACGNYGALFSLTFSSILASQTFFDALPCYKGPSLGTNFTLACPYTILAHYTELDWALEWGVEKGLVRISAGLEEPELLKEWFGNALEAAERAVREAKGRGENLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4W9</accession>
    <name>A0A2S5B4W9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4W9"/>
    <dbReference type="STRING" id="741276.A0A2S5B4W9"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051211">
        <property type="entry name" value="PG_lysyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34697">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34697:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="358" mass="40461" checksum="430A654CFB767E18" modified="2018-07-18" version="1">METSTPRTSMSSRRSSTASANSLIEQQDKEWLPNLIAKYGYSPATAWLEPRYAVWRSPEHMQSNPRVQGYLARGKFYFAWGPPVCRDNHDTRASVAKEFIEWATKEKKRRVAYCVVDTAFSEILGQELGWSVLSCVREDRLHPEIKKLDTKEVRHAIRRADRAHIKCDELHLKAPNWTVPPEVKEEIDEGLAAWKSKRTGTQIAAAGLHPWMDVQHRRYFLAKNDKGKIVAICVLAQIAHDSYQIKHAVTFPDAPGGTSEGLMGHVIRELNFEGRAGLTFGASATESLEIEHNLGGWKIKMLGKAYRKIVSRYGLANRGQFRQKFGTEDEPLHIAYAPGSFGWSGLVALMKLMRVDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4X4</accession>
    <name>A0A2S5B4X4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Macrofage activating glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4X4"/>
    <dbReference type="STRING" id="741276.A0A2S5B4X4"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015447108" description="Macrofage activating glycoprotein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="38930" checksum="2F8FB290BDE1A1A0" modified="2018-07-18" version="1">MLGNVLVASALVGTALAQSSAAFTPLAAKKFDYNNLPYQADSDDGVRGRQLGYNRCNSTTENQDSLCQTAIINSIDDFCFWAPPRPNETVGDIEGEMVAWCTKEGHGTRIIPEGALQGVQFIQTPHYVQVVGYIDQVKIDLMADDYGGEMDPHGADQRGNPLGGLLFSTAFGGNSTTTGTVGGQQYQQFCLKACDPSYENGWAMCEHIFDRIGCKYNAPSDWSKINGTFEACKGDDQLYPGQYVEGGVTRTYTQPPESLGVITTIPYEPFTPSSSQCTPYTSSRIYTAGRQLAVSTSSAASSTRTSGASSSQASQTSASGSSRASAAASSASGSAGAQGAAQSGTPQSGALEGFKVAGGLVAVVAGLLGAVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B562</accession>
    <name>A0A2S5B562_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000069">
        <property type="protein sequence ID" value="POY71922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B562"/>
    <dbReference type="STRING" id="741276.A0A2S5B562"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="196"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="284"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="578" mass="59498" checksum="B550FEA846B98194" modified="2018-07-18" version="1">MDSWTQPDFLSAESADDYLAGLTSFLDADPKGAALSAGGYPHVTPLALGGFVTGGAAGVSTVDTSSLLLNDASSPELTSDSASPSSSDGNAVSHGQYRQLDSYGTPSSSKGGAAQSTGTPSATRGGRSSPTRQHHADPKRKNGNGAQGAIKDHRRTSDSGAGHHSHATGNDGVTARSESPDGSMDGKGEKGGKTSERRKAQNRQAQRNFRERKEKHLKDLEERVVTLEEQTKTQDAENAALKQLLDNLRSENARLKVYETAFTFDYDKDVSNSSAMPQSTAFRPPALTAPSAVSSTSSSPIEAVAPSDRSDSFRFSSGPSASTTMSSTSSSQANSPGMFVNASSPDVKPSTSALENALASASSSGADDSLFLTSFVNPSPSPFSSFTGLPVASPEAMSSDIFKSYRDPLASLGMPSSDLSTFADLDALLAGPSSDMNSSSDGPASALSPATQDALSAFLNPSPPALGTPSQSPASASAAAPAGATPSFSTDFGLAVGSGASPAGSASASCPYGIHPDRMAEYEQYKKNPTGKFDFDLDGLCAEMKLKATCQEAARQALQQAMLEDAAASRQTYPSAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5A4</accession>
    <name>A0A2S5B5A4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000069">
        <property type="protein sequence ID" value="POY71915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5A4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47839" checksum="3FBDAFABAF7815D1" modified="2018-07-18" version="1">MTRKCRSPTAKTINDLPDEIVTLIGHHLYSAGLAATSELQPAAPLATCRRFRQLWTPLRWRTVPASGEDDTEHAELLFQPRPVLDAVREASLHLSDDPGLNRLRCAVLSQLPNLEVLSIDSDDEVNAEFEVVRLWQRLRGLRSLWIGRDVILDFDAQQTIPPIKRVSLYSHRYTLALSTLCLQAGVKHFWMDWRGDLDTVLPWGTLTRLDLEFRPFVRPSELSDAARTLSSQITSPNTCRLRSFRLKYAGAAFGTEAPSIFDFLETAPLKELQIELPRSNHPDLPSFDCPSLTRLTLIQPLALFLTPPRNSLLRFIKLSPHLTYLNLTDAAFDTITDSWDLLDTLAVTSDATVLEDFPALFVFLHCLRSTSVLRLDLNEMSTERETHFGLYKATARPSIRWTRSCADQDFERQVWWDVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5A5</accession>
    <name>A0A2S5B5A5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5A5"/>
    <dbReference type="OrthoDB" id="2561733at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="721" mass="77898" checksum="23231E3372D1BAB5" modified="2018-07-18" version="1">MLASGSHQAETYNQTRTAGPSSRKPFDMADLAAAALARPRAVEPWAERDDLAECPPSPSSAGSASPYLRSPMSPWSEATSCAMTPSSSAGSFCLPPPLAAPPAAVPRRRIAPSSSLPALSSQLPPLPTPHRPLPRTVSAPVLPPIAPADPWQGADFSLKLLFTPTNAGRTRNAPAVDDSLDNTLPPAFFPSQRISFSPRLRIASADGLAFSSLGGMHLGVTGMCEVLDERGVVKSQRMIADFCIDLSSGLRVWKRDAEAAAAARKHDDATGSDDVRLPPGTYVLPLSMKVPNSDRLPPSYECAQFRITYTMSIALFSAATNSNGTPRRLKVFSVPFHVLPSTLPVPAPELPTLTHDHKKGVFESLMRSFSFSTPKINETGFHTIIPAMPTSHYSPGASSAVPVSLRIIDRPLEPTDLYVRLAIVRKVYVRESTRVSLERAIEERWGLDEGVPVATLGYPEEMLVEPWCVEEEEVVSRWAWIPYSARPGADPEEENEVELKNIMLPLCGADGRGWTHGYSSSLDLEPSAVPAMTHGDCSWFSPAFRTRAPVAREYEQHVHASSRFYLSMEIGFAPPTLRDTLAHLHRQTPDMPIPQPFEFTAPTAAATSVYSGLSTSNPFFAPSSRATPTQRATPASPLAFPGKLRELLIPLTIGSVAEPGLACLGGQATSHADGEARRRDREAREERGEDARAVHGEGEEGAWLCAPPDYAEALETAPAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5Q6</accession>
    <name>A0A2S5B5Q6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">BMF94_4841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5Q6"/>
    <dbReference type="STRING" id="741276.A0A2S5B5Q6"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="300" mass="31692" checksum="79068D91FA501D88" modified="2018-07-18" version="1">MAVPHPPTATDIEPLTPDEIARIPSAALPISLQISHLLSEFTRLSVQLFAIISTTSPSLVAGARGSAPTDAVYDALAQIDEKLASLLGMYDAHQQRQRRIEALIGELSRLDSNWRSSALRLEACVAELDPILASGKLDRIAIDRAKEAKMTPDGLLAYARLIAPFTSAPPASLFPPEIKLKGVGATDPTGRTLPPGAIPPFPTEATMRKGRLQFGREGLLQGYLGETEQVGAGRRDSATGALLPPDPTTTAGKPADTAARLEHEAKAHAAASALTTGAVLDGAEPEAEDFVFDLDLNPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5W4</accession>
    <name>A0A2S5B5W4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5W4"/>
    <dbReference type="STRING" id="741276.A0A2S5B5W4"/>
    <dbReference type="OrthoDB" id="10672488at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="334" mass="33172" checksum="CE29890B4B4E790E" modified="2018-07-18" version="1">MSSLINKAKEALHSHSNKNDSNSSSSDYNSNPNYNDNSTSTTTTTGNPDSYGNSSSVDQRDNTFGSTDPGNFGSSAQRRDDTFGSSAGSGPGQSSYDGPSDVNNKGFPGGGDGAGAYNDNSNSTSAGTDFQASGGGSSSLNPAYLLDGDGRNDFTGSGNQNNFSGGNDSGSFGGATGGFDDSNRAQYGGGNNDSNRRDDTFGATDSSNYGQSSGRRDDTFGSSAGADQSSYGGRTDDSNSGFPSGGDGAGGYKSRADGGYSSGNPGTDFQASGGGSSYGDGQNDFSGSGNQGGLGGNTSGYSGDSGVLSRGDQQGQFGGGSTGSDSYGSGDRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5X2</accession>
    <name>A0A2S5B5X2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5X2"/>
    <dbReference type="STRING" id="741276.A0A2S5B5X2"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="53"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="234" mass="26236" checksum="CD501114EE7E9CD2" modified="2018-07-18" version="1">MTVQPQYLPTPVPTPPPHHSMAASASLLSKKKQPQPPYLPNRYDYQPTHADLFQIQFGPEGEEFGSCLRAQKPFKRGDTLCPIRNTLPGVKAYSSVQVLPDPPVSSESASTSTSERRHIELNSDLLYVNHSCDPNVVFDVNGREAHVGEEDESGRWEGRWRVRAEKDIAVGEILTFAYFSTEWDMDQPFSCLCGTERCIRTIKGAKDIDQAVLDGYFVNDHIKVMKQAQAKATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5X9</accession>
    <name>A0A2S5B5X9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5X9"/>
    <dbReference type="STRING" id="741276.A0A2S5B5X9"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="61"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="469" mass="52580" checksum="C3FE165246E3B20F" modified="2018-07-18" version="1">MPSPTLSKRATAQMDATAKSPLFSAIFRTFGNQWSEANPDGIVNAGLAENSLMHDWLTTFWERQGTLKINHTDLTYGTSIFGSDRLFQALAGYFRSYFDPLTPVEPKHIATSNGLSPMFEHVAAVISDPADAWLIPAPYYNGFVPDLNATSQVQIASVNIPVDKYGTVAEVHLLDAEMERREREGATQKITAVLVTNPHNPLGFCYSKEVLLEYCRFAERWNLFLVSDEVYATSIYDSPDLPNALPFTSILSLNVKEDAGCDPSRIMLLYGMSKDFGANGFRGGALVCQHNEKLMQAMSSNAMTVRIGSPTDILWSALLDSPELPSYLAQNRRALTRAYTYLTDWLKAHKLPYTPANAGHFVLVDFREHLQEVEREGERAVEEEGENAPRRRKDAEEGGRFKHEIVLLNRLVDGGVYLGPGFSYVCSEPGFFRITFCIRRKELEVALDRIETVCELSRKALEISRRCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B667</accession>
    <name>A0A2S5B667_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4701</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000052">
        <property type="protein sequence ID" value="POY72267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B667"/>
    <dbReference type="STRING" id="741276.A0A2S5B667"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="317" mass="36255" checksum="A05E548251BA1B81" modified="2018-07-18" version="1">MMWPDYWRTQPDNPIWAIIGVPCRDEWEMEAGQILIDKAKHLDALLLAEWMMDRERFSYWFNFSDGDKDMFRFAFLALRKRWAVPGRYVSVGALPRDTMSGFCGLTMLQNDHVGRPMFVHYNLLKQVSSGVGRGFAWGRHRQVRTPPSSLSLQGPAAEAGNSRDRERIDPLRDDDVDCDMLANARNDGYAMDRVGMDEVGWRTRRRAVWEKGIRSGFHGGWFSALCIDYHWDDPRSDEEKSDSRHSVALGMANPEHKSLDELADGVDISYTSAPDGFEVKFDSNEVLEVVQWGDDPRLRDFEAAFFDEGGVVNGQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B688</accession>
    <name>A0A2S5B688_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B688"/>
    <dbReference type="STRING" id="741276.A0A2S5B688"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="377" mass="42893" checksum="0643E65D1995B2EA" modified="2018-07-18" version="1">MKPLRMKATSSADEAVLRAQVRAQKKSRKRHSRTAEPQSHGPGHRAESLTPPRNPPKPEPILEDDDWGPDESALPPEQAYKRTRTEDEFYESLADAQAQDQGVGYYEDELFARQVPAYATHYSSAAAAAAGIDPNPATKSTWLSNMDDDEYAEYVRAGMWRVKNKAEVERMERAEKERKEREERERREQEKSRREERERIRKLEERKKRKTKEEEEGARQRYDEGWRKLQHAVATAPPPPPARSASKSATPSTEASADDGAEESEAIASTAQANAFPLRFSDFPWPLYPPMAFPPLSWPSTEDITSSAVSAFLLPDSLAADKHKNVLRQAVLAYHPDRFERYVLKIPEEKEEVRDRVRELGLRVSQVLNDLSKKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6A7</accession>
    <name>A0A2S5B6A7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_4577</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B6A7"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="15">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="14">
        <location>
            <begin position="438"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="632"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="945"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="1313"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="97"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1188"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1405"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1188"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1237"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1410"/>
            <end position="1430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY72275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1456" mass="163608" checksum="21D7DFD2A6C7DDCA" modified="2018-07-18" version="1">MATSATQGGQDPPPMAPQPVQGQGVTPVPLTSEHLRRVIGKSRPYSTPYRPSAIKLTPGTNTARIQQLKAEGATPESSAELANLTRIVLAVQAQRQRAQGPHTHISLRTESGPQLTRAHRDAAAAGGPVPVSAPQPAVNGSTNLTTPAPSTLTAAPSPDTPQADPTKGAAEPAADPYTPTLSPSTVPFTPEQVAALKCQVVAFRLLARNQPIPPALQAALATPSEALKFAAAHANDDSTGQDSPAAAAAYGASNDSADGSAGPAEARPKIQVEEASVDSVEDPNSLVYPYNAFLSPKEVLRSYHGVAGHEPFLIPTLMPAGLDPQSLIDERNRYIEARIYQRRRELEQMPANLGQNSLPGLGTDGDREQQLASQKLRALIEIKSLNLVERQRALREQIVQSMRPACSLAVPLDRSLFRRSRKPTLRDATAIESIEKRQKQERERRAKQKHLDHLAEITEHGRNLLIAHRAHTSKFQKLGKALLKFHVDAEKEEQKRVERVSKERLKALRADDEEGYLKLIDTAKDTRITHLLRQTDSFLDSLAAAVSAQQQEARADLQATDGAAEEQKPAANDEAVDESRFGANPVFAEETKDKVDYYNVAHRVKETIDKQPSILVGGELKTYQLRGLEWMVSLYNNHVNGILADEMGLGKTIQTLSLITYLIETKKQPGPYLVIVPLSTMPNWISEFDKWAPSVRVVSYKGTPAQRKNAQAEIRSGNFQVLLTTYEYIIKDRPLLSKIKWLHMIIDEGHRMKNTQSRLSVTLTQHYSSRYRLILTGTPLQNNLPELWALLNFVLPKIFGSVKSFDEWFNAPFANTGGQDKIELNEEESLLVIRRLHKVLRPFLLRRLKKDVESDLPDKVERVIKCKMSSLQVKLTKQIKEHGMIYTDGPTDTKKASGIRGLQNQIMQLRKICNHPFCFEAVERSIDPTGANDATLYRVAGKFELLDRILPKLFMTGHRVLMFFQMTTVMTIFEDYLNFRRIEHLRLDGTTKHEDRSTLLKLFNDPNSKYPIFILSTRAGGLGLNLQTADTVIIFDSDWNPHQDLQAQDRAHRIGQKKEVRILRLVTERSVEEHVMAGAARKIEMDKKIIQAGRYDNKSTAEERDAFLRALLEAEEGEPEDADDADEADMLNEAIARTEEERVIFAQMDRDRRAAEEAAWIAGGGKGKMPERLIQEWELPHVYRMDHPKIVPEDENRDGVRRNRTNVQYDDGMSEEQWLQTMEEEEDEPEKKRTKRAAAERPPKYSFEEPLPSDSEDGDSRRKLKRGRQSGGATPSVNGDDDTSRVSTGKRRKVQLSPYQEMMRECFDTILTELEDLDNLFKQLPDRKIYPDYYQFIKKPISLKEIEKKVNNGTYSNTNVFAADVHLMLDNAMTYNQEGSVVYEDARLMREVFNAAYSRLTIDGQPRSAMQPQQGQSIQPMQPGQPMPMHGMYHQQQQQQQYAMQPGLPMPPGMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6F0</accession>
    <name>A0A2S5B6F0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6F0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6F0"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="116"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="553" mass="60455" checksum="E0354FF54891A7F9" modified="2018-07-18" version="1">MLSRTLSQGVVQHHLDPREELVFPQLTERGPHTDAYLEESATGLVSAREAEAQNATFASSTNASPATRIPSQSTLVSPGSDQPIREKGGPDAKLVTWLVDDPHNPRNWSNAKKWVQTIIPTVFCFVAGFASSLITGGLPEQAEYFGVSEVVMNLVVCVFVIGFGIGPLFLSPMSEMYGRRIIYVTSMFLYFIFILPSCVTTSFAVMIVFRFLSGLFVSAVMCNAAGSIGDLWEINERGYKMVAFSGILFASPTTGPLIGGFVTITRGWRAMWWLLFGFSGGVWAIGSAFLVETYAPTLLQWRAKKLRKETGDMTIMTEQERLGRPVREIARETLLRPIVMLTTEPIMQCMAGFLCLVYGVLYAFFFAYPIVFLAHGFNAGEVGLTFLSILVGIVIVILVGCPIQERYYRKQVEKCGGGIPPPEARLPLMMVGAVILPISLFIFAATSPASVHWAGPLVSGIPFGFSLVAIYISANTYIAVAFSEYSASAMAAKTFLRSMAGGSMSQWVPPVYAAIGHFWGGAIFAFIAVAMLPIPFIFFFYGARIRARSKMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B737</accession>
    <name>A0A2S5B737_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B737"/>
    <dbReference type="STRING" id="741276.A0A2S5B737"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000011">
        <property type="entry name" value="50S ribosomal subunit protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="149"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="305" mass="33204" checksum="CF0663AA72693211" modified="2018-07-18" version="1">MSLTRMLGRLSLQPVAAAGSRPLSTAALVSGRRPTVDSIAATSIRAAQTQSAALREATRRTVPARRAYATEASHLGNLSPHPGSAHKRKRIGRGIGSGKGGRATRGQKGQKARAGNGKPKAHFEGGQTPLTMRYPKRGFTNPLKQNLVPLNLERLQHWIDRGLIDPSRPITMHELFQSRCIHGIQDGVKLLGDGAEHFRTPNVNITVSKASQSAISAIEALGGTLVARYENRLTLRALTRPESFFAKGLDLPGKANPISRRELLYYSNEKNRGYLAIERLADRGEREQAHEPAKAEEDKPADAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B739</accession>
    <name>A0A2S5B739_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B739"/>
    <dbReference type="STRING" id="741276.A0A2S5B739"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000003">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="338"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="421" mass="46986" checksum="EEC04B0396831F60" modified="2018-07-18" version="1">MALQGDRYRHVDRVLTRTGPWAEQVSFQGGDETKQFLREQCKVLVIGAGGLGCEILANLALLGFADIHVIDMDTIDISNLNRQFLFRPSDVGKSKALCAAEFVMNRVKGCKVTPFHGKIQDKGDDHYMQFNLVICGLDSIDARRWMSATLVNLVDPEVPESLKPLIDGGTEGFKGQARVILPTITSCYECSLDMLTPPTAFPICTIANTPRLPEHCIEWASILEWPRVFKDKKLDNDDPEHIQWLFDTARQRAEKYNIAGVTWQLTQGVVKRIIPAIASTNAIIAAACCNEAFKIATSTNPYLDNYMMYTGNDSVYTYTFQHQKKPECPVCGGEKITVSRDPASSLQDLIDMLLERQDLQIRRPSLRLASKSLYLQAPPQLEMATRPNLEKSLGELLESGDVVTVTDSSLPFSLDLIVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7I8</accession>
    <name>A0A2S5B7I8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7I8"/>
    <dbReference type="OrthoDB" id="2530479at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="235" mass="25124" checksum="7C99F20A7B4E993B" modified="2018-07-18" version="1">MHSSSDRPFLGLDDGFSEEIGTIMFLPGFHTCGTLSIVSLDPALHLTQADLEALPVYNGSLQERWLEAPTAVREGNSSEGTILAWATGWRNTCGRGAANKEVRVTKLHIDGLGEGATVAERAQAIDSQVLPHLASLPPAPHNSIVLVTSVCESTLQRLFDAATPVRSSPSQPPSSGFPDRRTRRTHGFFRRILGRMVEWTLLGLVLVGGVQAGQSGKQDDGSPCPMGTTRNSASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7L1</accession>
    <name>A0A2S5B7L1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_4167</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B7L1"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="300"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1486"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1837"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1938"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1494"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1940"/>
            <end position="1951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY72760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1961" mass="210898" checksum="75BDC167130889C1" modified="2018-07-18" version="1">MPWPSLDAFIAPLASAASYLPSLPSVPIPAKLQQRLVAFLLRRAIGGFVKGGGHSLGDEGRIEADVRNGRFVIHDVDIDDQVVNSILTSTLTDPSHPRPVSPFRFESGTIGTLTALVVWPLSRFDVQVEDVELVFRLDDQDLRFESDLDFRPDSPPRPTARTASTDDEDDEATYARLAESNVSLALAHEFVSHELSPAEDAELRASLHLSPSESIDLPGAFGGGQRVFEEAPSVGNQAEEVEATMLAGVVEKVLARLGIQVRNLRVRLKWDTEAGEEAAAGQGEHELELRIDNIAFAGTSENTSSASPRGSSKRLSLSPPKLYFHSRMPPAQDAPAPSPTRPVRAPFRRSSSSSSSSSSEDEHDILAMSQSIADLRVSSHTNTGGSRSDLFASATSRYFDPVTEEAEEDERPESPFVDPDASAGAHQDGLHGRAGEHSTTHTELIASVGTREEIIFEVQKPSTATFSESESSGRTSSRRTLKLDGTIRDDVVVALRPESLEVLLSLASRLTELEVDASGGHRIGPPSTIPPTSSSELRLTFGMRAVTVVLASDLGIAIPDQLWTRPAAPLNLPHLRLALDAITVAIQQPTHELGVAVKAFAMTEVIFSGNGVAHSLPILVSDSGLSAPSLDSWPNVAVHSVDWLKGAHQQYGRDWRVQPRTSSVRQHPSKAPDRLPAEDITAVSLGMRPEKGPSARLAPVHAFLDPGILNRHRDLQRVLLLGLAPSDSATDSSLPPSTRSAPKQATSLAFEVRCPLVRLELRCPGPIAMRREADDPDLLRGGRLLLDVGGLDSRFDDTSSRIQLDSLRGHVALPATSDAVAFFTLSKLTPYDEGAPALLPTATFRKPLELREPPRLDMQIPFARVSLRKSTFDALQLCADDLNRFFAKEITSPLSGDRRENREASGNKLIGSRYFGAKSYVRPRRTSRTSGGFAADASDYDSSASTATLTATRMDVPPAGLPPTATLLCTVAVTDAEAVITLHPSDDAETGLSKENVKLMLADLRVDVATFADGPDDLRVTLSTMDVRVLRCPEDARRPPSDPIVTRTLRRNPTIRAPSMIELVYTCRTDRDTGVKESRVQLDLSDGTFSLGPDIRWLNALQDFVKAPEGVFEEVVPNELVRLRVALHGFCVKLVTPAATPVVVIALDKLRLRSDLKPDLLRTSLRADLSGTSVLAIQDDDDLVAATAGSDEPRSLEVVGHWKSLGFTQIAADLRSVLEVRVGNGLVLPELDVAIEHVSGALALCADTLSAVSDFAAGLAKLAGSPSSGSGPQSRKSAAGRAPSADLLASLDFSAFDRTPSVGAIPVDIRDDVPLNAKYLNDAELSARPMRSAKTSRSWQSTSLAGETITMLAPDGLKIVDEWLAEPRLAETRSSTAETRVVVRHCDFTVRLHEGYDWASTRKAIAERSKAVRRRLEKIRQLLASGQAPDASGEDASVVMFGSVQLGLPPGAEDLPPKDLLAAIDQELGDGADLDEPSSVAPTWQAVSEDATQRSRGTFRATTTGRGGRPRRRLTRSSTSSIDIHLRGMNTSLELYDASAEAPAVGSARPANAVQSRLDVKVTELDIIDNVKTSTWHKFLTELRPSDGGVVRPRNDPMARVEVQSVLSEQVAGPAQSEILLKAKVAPLRLYIDQDALDFLKKFGAFEASAGSAGAASAKPTPPAPFYQRVEILPVRLKVDYKPKRIDFSALRSGKLAELMNFFHFEGSEMTLRHLNVAGVSGTSTLSNLVQDIWTPDVKANQLADVVSGIAPLRSVVNVGSGFANLVLLPIEQYRKDGRLVRGLQKGAQAFAKQTTLEAIHTGAKLATGTQVILEQAEHVLGGTFSRPIATETVASAVGDDEGSAGGDGHSTDPRSRYAAQPVNLRQGVEGAYKSFGENLKDAAQTILAVPLEVYERSGDEGAVKAVVRAVPLAVLKPMIGASGAVSKALLGLRNTLDPHTQENELRDKYKPTTARPSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7P3</accession>
    <name>A0A2S5B7P3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7P3"/>
    <dbReference type="STRING" id="741276.A0A2S5B7P3"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="411" mass="43019" checksum="DFFF251C79BA3881" modified="2018-07-18" version="1">MTEANPRRIAVIGGGIIGTCTAFYLQRLAATRGRSVSVSLIEGSQIAAGASGKAGGLLALDWHGPATASLATLSYSLHAQLAQELGGESKWGYRKLDTLSLSADLSSSTASSAAKKSRARKLKQDDLFNWLNKELLTATDVLASQETTAQVHPELFTRAIAEQAQKEGVEIVYGTVDSLRRLDDAYEVTVSPRNADFPSPAADDDATSGEPSARHLVFDQVIVAAGPWTGRLVSTLGLGAAAGRAKAIRGSRAHSVVIRSPEGKTLPAQALFTSIKEQKGKHAEPEIYNRPDGTAYACGPTDDSDLPKHASDVTISQSAIASLLAQTAQLAPDYLDHENGARVEREQACYLPVGSGDPVLGKIEGQGDTGVWVASGHSCWGICNGPGTGKVMAELVLHGKATSADISQLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Q0</accession>
    <name>A0A2S5B7Q0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Q0"/>
    <dbReference type="STRING" id="741276.A0A2S5B7Q0"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="86"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="341" mass="36731" checksum="67744916CD5E6284" modified="2018-07-18" version="1">MLRSVARAVRPRVGPASRPAPRRTLFWGATPGAAASAATAGAAAGSELTATHVPSVAGDLLPLVLGVVLAHAAIDDEGDDDRLTQPPWKVESFGDKGSGAVAARDIARGERLIAERPLCIWPNNLSEDEARRLFEAMTPTEQSLFMDLARTEGTGSVKALDEIRARRATNGFSIPLLDASGKSQGAAGMVFPKIARINHSCTPNCAQAINYSTLRMEVYAVTDIPQATELSIEYLPGMITSSAAERRQALRTHFGFDACLCAVCSAAPDDLARSDSRRREIKVISQSFRYGGGGDRKAKLAGLQRIQDLLDEEGYKGLPDFGDSDLNRAFTIFRTMRNRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Q8</accession>
    <name>A0A2S5B7Q8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_4217</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Q8"/>
    <dbReference type="STRING" id="741276.A0A2S5B7Q8"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="25"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY72808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="557" mass="61441" checksum="E9EA5A7459084F4F" modified="2018-07-18" version="1">MVNLFERVEDRPTPKAVYNWRVYSCAVVAASAAIMIGYDSAFIGTSMALGSFKKEFGLTTKTAKEFAGISANIVSTYQGGCFFGSLLGYPLGQLLGRKMGLLISSIVFLLGAGVMLAADHARGLGPIYGGRIVAGLGIGAASNLTPLYISEIAPPAIRGQLIGMYEIGWQIGGLVGFWINYGVTQHIPSSRKQWLIPFAVQLIPGGIFAAGIPFFIRESPRWLISRNRRAEALKHLCYIRKLSPEDPYIISEMNEIDIQVEHDRTAVGTGFWAPFKQVLGKSFLLRRMLITTMLFMWQNGTGINAINYYSPTIFKSIGVTGTSTSLLTTGVFGVIKTVLALVWCFFVIDRYGRRGILLVGAAGGALSMFAIAAYNNIKDPSNNPTKVLPPGGKAAMFFFYLWTAFYAVSWNGTPWVVNAESFPGAVRQVTQCFAATSNWLWNFVISRATPTMFLNMGHSGYGVYLFFGAMQVLSIPYICLLLPETRNIPLEEMDRLWAQRNTWHANKIVMDELRREHQLAAEHGQNYLKPTEGVRTEQIEDSMAADSKLRGEASDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7R0</accession>
    <name>A0A2S5B7R0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7R0"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55746" checksum="1253A2E3B9D6CE82" modified="2018-07-18" version="1">MAEEIELAAPRPTLARVDSLAKNPFRTPSSASLADFESFSRSPTPAAQLPDLPSTPPPAQTPPASRRRSEVDLQAEEAGQKMRRMSMGDETGTDGMSLPPIDKGKDAWSFCFAAFILETFIWGFSYTFPSVLVYLESHDPWQKESIASLSAIGTVQLAVMFIFPCTIISFFRRYPDWVRTSLWVSVAVNCLAMLAASWATKVWQLIVLQGVLCGLSGAVLYTPVLLWLNGWFHMKRGLATGIIFSGTGVGGLIFPFLISSALLDKYGFATMCRAWAGITLAVYAIAVYLIKPRVPLRKPRGPRSPWFVMSDFRFLKNPVVIVMTLTSFTSSLAYFPCSLYLPTYTSTLASPVSANIVVAVFNLAASCGSAVIGYTADLSTPITVMASGLAGSLLALTAWGFASSLGAVFAFAVLFGFATQICSTWGPAATDAVGANPHLATLVFCTFGIFRGIASIVGPYISTTLFEPVIAQEHAAWGRFGFRRVIIFVGAMSALSATGGAALHWARKYNARVKAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B828</accession>
    <name>A0A2S5B828_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B828"/>
    <dbReference type="STRING" id="741276.A0A2S5B828"/>
    <dbReference type="OrthoDB" id="2529834at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="226" mass="25456" checksum="F62D25DBB1442B16" modified="2018-07-18" version="1">MTPNDIQKAQQANLLDFLLTAPNQLANKPSLVPNADFTYCSLALTCNESISSVRWNGVCYMTGSDVVRIVAVRLASAGIAEPDTKLLKRNVVSRLRTIKEGRGMLLEPANSRLLTLLFQHNLISTRKSQKLFCWYQVPHDQLLEHELAHHRWKAGLPPLPKTLLRAPAFVDGDYPADHRLRRVACGVGDCPRRFTRLEHAQRHRAAHVQEKPLEGTTARIDRTANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B863</accession>
    <name>A0A2S5B863_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B863"/>
    <dbReference type="STRING" id="741276.A0A2S5B863"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="74"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="227" mass="24748" checksum="454F50832A78A9AD" modified="2018-07-18" version="1">MSATSYATAIIETALSSEQPILRFGDFTLKSGRQSPYFFNFGLFNSGVLLLELAAAFADAILAAYPQIGQKDASHETPRVLFGPAYKGIPLVAAIATELARRGRDVGYSYNRKEKKDHGEGGSLVGAPLKGERVLIVDDVITAGTAIREAHKVVQAEGGQTVGIVEALDREERGQGELSTVQEVEQELGAKVTSVVRMRDILFWLESKGRNDEVAAMARYREQWCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8R7</accession>
    <name>A0A2S5B8R7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8R7"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48362" checksum="B92A0B7AA67D0ED8" modified="2018-07-18" version="1">MAVFLDLPDELLELIFAIARVRYWNVDYAAGRMDVRLLLVQKSRLEPIVEKLFSAYIDGPPNGQDPLTYYARLLLRPPEIKKAVRALMLDLPVDPRAALACAALIAQLPSLEHLFISSSEPIPGDQTLVLPLGVLQACATIRDLFRLEFWGRCVLPPGPLPPLPRLQVVRMYASSLDTGMSSYLAAAHIKRLHLYFSTQADATFDAGPLATVEDLVVEFLEPFFPDYFETLVCKLRRRFNECSQDLELQSLTIDAPLCHYDVDLRWLNSLRRAPLRVLKLLFASARTLKYPQVTLPQLQRLVISACADLTEPTTLQDLLAFLKRLPKLKVFDLRAETLYKTKGRRQVSLSKALAPELSEDASELRAVVDCLQEKGTVEFCARTNASPSEQFFGLYTARAEQFLRWTRQGADFKPSVFWDVLFEASSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B936</accession>
    <name>A0A2S5B936_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B936"/>
    <dbReference type="STRING" id="741276.A0A2S5B936"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="760" mass="81765" checksum="7F22F13E04628C54" modified="2018-07-18" version="1">MQPFVDPARKLRAALSDCTSTHPTLDYIIRLAFRLPTDENGHRDYRNTDPQTRQTSLHLAALKGRTDVFEWFLEEGVDEGEVSRDVVGDTVVHIAAAKGYSEIADLYLNRYPFVVEWVNSRGMSPLHFACKEGHLEIAQTCHRVLIDDFQQLLVEVGADLDAPDLEGNTPLHYASAWGKISLLRFLIDQDCQTDWRNNEGFTPAEFAFSFGVLRELESAIKQHFDDLKDARRQARRDRRSKRAQLQEKRLGPASPLSIRPPPAGEHADGPGYAMGLGLSKQQSTESNDPDNHEGFPRLGQAIPPTPRNGSPRYAVNAFRDQRPPLRQTANSPPSSPMSSVFRYPNTTSPQPSPSASMASSAVPITAEDRVASQDGASSALRSVSTHSSLTAGGQSDAARSPSRITPIPAQAHVFRPPHRKHSSSFGAAGVALAPVFDAVRPEGSDAPPLAPPVLAPVPGLSPSTNTDYAHMPENWPPGAEPLLPPAPSPPPPAHHNKLVRKSRPGSAVAGRASSPASPPQPTHAWFEPTVHSRTMAEQSDALTHQAGPPLDLASAYDSDGAQNAPPDSLRDLGQQPSSSQQFAYGQAHQPLPAARAVILPQHPQAMLPPGRNSVDGRRSVSGPAAAAHYDSHYPRASFETDGSARTSATGSSVIISPYRGPRGAGTMHDPRRAVSHAQLRQQQQQLQQDRHSVRLVPPNAQSTTSLPTGPVASSSGRAKLRKHRKGSHDLTRTTSASTGTGSVKSGGGRLARAFGFGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9K1</accession>
    <name>A0A2S5B9K1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9K1"/>
    <dbReference type="STRING" id="741276.A0A2S5B9K1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000067">
        <property type="entry name" value="Endopeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="280"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="311"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="712" mass="74158" checksum="E8CBA771C27DC1E1" modified="2018-07-18" version="1">MNSPRGPRRRRRTTTSASSADSISSTLTALIGLAVACTAVHATPTHPAALPSRLAALPAPTWATRPGPVAVGGLHVPLLRRNGHLRALARTPNPVDQSEIVAGWALREKGRVAVKYGVGAATANDGGVAVVKRADEASERRDSDQEQYSELVDETDGPQLERRPRRKSRRRRTPLSEDDSAARAPGDNDNEARDEAQEEEEEAILSLVRRQLGGPNGGQLGTATSTSTTRTALSTAGYGTATRSGNNSATRTAPTSLPGPTSTMPVGDVQLTNYDADLSYYAPIGIGVPAQYMNCILDTGSADLWIASTNCTSSTGCSSTVPLYNSSLSRTAVDMNTSFSVRYGSGQATGEMMQDYVAFAGYNVSSQAFALVQSVSQDLLGGDISGLMGLGWQPLAASQAVPWWQNLYQGNALPFPGFAVSLSRFVNVPNASSVEPGGSLTFGYLNSSLYASEINYVAMPSGQESYWLIRMDQVAVNGTNVTSWAQGAGQMAAIDTGTTLIGGPRDVIANIYAQVPGARAATGAYTGYYSYPCSANVSVALAFGGVNYNMSTADFNLGPFGIDSRTNQSTCLGAFFDLAFSSSSRISWVIGAAFLKNVYSVYRANPPAVGFATLSNSSHPMPYYPSNSSDPAHDGNLTAIPGGIYGPSGAPGGANGGANAGVRTTLVAANTVTTAVQVGGAVRSLADATTWMRLGVSVVAATVLGFGVGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9M8</accession>
    <name>A0A2S5B9M8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UFSP1/2/DUB catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9M8"/>
    <dbReference type="STRING" id="741276.A0A2S5B9M8"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF4">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MUG105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="234"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="610" mass="65617" checksum="F439FF702C3673B5" modified="2018-07-18" version="1">MQCYVCSEVLDGDPAYVQHHLNSCLDRQGPSNGSPRRDSQQQTAAPVPAVTSSTLTLSVTSSNEEHDRLLAIALSSTESEPTSSEPSNRNPTAGSCPCCHQSWLTLGLTTGDSPSDLAALDGTEQEQRASHVEACLMAREEEEDAGQRGDWPAGGQHGRAEDDDDGDEAAERKGRQVPNGVGAGMKGATTSRAGGGGDAVHETAVLSTPDLIHLLATSLSASHASPHGRTSEAYLATDLVHHVPTRLKDYGWGCGYKNAQMIFSAFRHLPQLAPLQPKCSGPMEDVVPIPPIRWWQETIEAAWRQGFDPEGAAHFKFRLVNSRRWIGTTEIYTALSFLGIRTQIVDFPKTKGGSGTNQNLVNFILDYFRQPNFFGAGPPPPPRDVPPVDTVPRSAFEVLTASRGTPVHRTGQHPLYLQHQGHSRTIVGIEIGKRSRVEGAESNGIGAGGGKLGSKVKGLTKVGKGTKGGKKSGGPRSQEEEEADGGAEEEVWLLLFDPGKPVPQDFKKSAAALAQARFGRHRSTSPAPNSEERDESPPLPKKVRPSPPAPAAMTPKFGEVLKLFRVNMRELKKKDDYQVLFIDPHAPPLTLEEKELRKKVSSIVIGGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9T0</accession>
    <name>A0A2S5B9T0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9T0"/>
    <dbReference type="STRING" id="741276.A0A2S5B9T0"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="449"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="98"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="666" mass="75299" checksum="6A3834620ECEFEC7" modified="2018-07-18" version="1">MRSSPLKRARSEPESPAASALVGAVVPPPSKRSKPASTSTEHDTSISGTVLRNVERLRAFVSQKLAAAAGSSSSLSANASTSTARFSHKSPKEVRAYLESLQRQIADLRHEHKSAKKEHTRVIMAAKQSNRPKPPKPDRLASLDKRLLELERERADHRELLLEAGDAAKGDRNGVMNGGASAGSTGRRDSNASGGSSYTRRKPMGMDQHRYQVQRRDQSDIEHLASQRAMAESAQALRQPYVLLSGQYENGVNDSFELDGDVPEADEDDPEGVEAYREQIDSLLQGKELQWHPRYTSTGRRSKTAQDLVGPSQLDRGAEPRGWGPPFALPELKGTTRYVPTSRVLQESQNFRPARLGDTPAAALARDFERLLSVARKTGKEPTKEHLEKYEALQQRIAEEEAEAERILQESKVKAIKKRQFPPKLSKENAKTVQDIFNNRGYQTSIKGASAAWRDMYRLSADDWLNDELINFYGVMINNRSNDADAREKAGEKNARGVGTERVLKAFCFNTNFFTMYTESGFAKVKRWTRRFDTFEKDIIIIPINHNNTHWCCAAVNIAEKRFEYYDSLGRPRDFVYKALREWLSEEYQSRKGTEIDLSEWENYWDKGVPQQGNINDCGVFTCMFMESLSRDAHGFDFIQKNMPYLRRRIALEIDNGKLMGLEPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9V5</accession>
    <name>A0A2S5B9V5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9V5"/>
    <dbReference type="STRING" id="741276.A0A2S5B9V5"/>
    <dbReference type="OrthoDB" id="10662316at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="639" mass="64798" checksum="5DF80E3F4BB892AC" modified="2018-07-18" version="1">MSNVVEADAGSIAQSPQKPALNQPDKVLFRRGNLDIMPTIDARQPGRASELIKRFQAQLDANVNNDSNPPPPAARMARTSSASSHSQQQRQSQDNTDVDPEPTTTGGARGDSEPELNCPRPDSAQLRADPVSPPSGHKALNRLADSLEMRSVDDQVHLRSAGLPAPPPVPKDQHKNARDAFPDVPAAPAASKSVTEDQDRAETDGSLANGDGRVVVAGPGEGPVHEAGASSGEVVANGAAAASEALDEHGDVETEEKPLPALPELSNSAEPAPVAHDHCASPESPTTSTASGPASPSSSASLPTLLPRSPAPRVSTVKAKPGAGSSGADASTPSRRLSPETARKAVSPTSASPSPRVRYPATGSRPASVSPSNSRSGTTRTARCDPKAAGSQTHAVRPDTARAPPLESSGTDARSLGTRGSKTFPTSSASRLTSPTASSLAKARTPASPSPSPEMSRSRSGGRKSTSPTQTRQAGPGSSATPSRSPLTLRGGTGAGGPPASVSPSSSSTAAPPATAAPLAAGQRKLRLGLAAAGRAQPAPVPTSGVEPSGPAAPVNTPAVSASSDEHKGDEPTAPAGGGEQKVFQGMTPGRPHGKIGIPVTFPEGPEGPMKAFKADEVEEAGKRAQADRETENKGREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA72</accession>
    <name>A0A2S5BA72_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA72"/>
    <dbReference type="STRING" id="741276.A0A2S5BA72"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60427" checksum="BFAA54CC5086F30C" modified="2018-07-18" version="1">MPDIITIVQEAPPLPSPAEEKEKFVGTTATFELAEVAAEPAHAKVHTVDGVSWTEEEDRAIVRRYDWNVVPIVFTLFMLSVLDRSNIGNANTAGMSKHLGISDPQYQWLLTIFYIGYSLGQPSTLMWKLVPPRYYVTFLTLCWGTFALLQAAVTSWAGFMVLRLFLGLAETAFSPGVPLYLSFFYSRREIGFRQGLFLGGAPLASCYAGALAYGISQIKTTSIPVYKVIFLIEGAPAVLMAGAAFFFLPDKPSKAKFLTPRQQEIARLRVSRDGDTGREGGLKMQGVKDALKDPKVWLCAVLNFCCNVSYSSLPVFLPTILKDMGYSSIRAQGLSAPPNLAAFFVLLASTFASDRVGDRTLFMIPLASIGGIGYLLLTLVKTTAIRSVSLGPKRGYFAVFLAASGLFSSIGLLLPLTSSVHEDDSKRTAAFTIFSLIGQLGPFVGTRMYPAAEGPYYRRGMAVCCGFAFSVSLLALAMRLYLQYENRIRDRKYGYVDPKKQEDLQEQARRDRDQVKADIEASGVRRVDKTAEEKKADQERFWRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAG0</accession>
    <name>A0A2S5BAG0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAG0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="290" mass="32383" checksum="82DAF0FA60689085" modified="2018-07-18" version="1">MLDRLPTELLELVVDATSHSIWSRKATLDSLSLVNKSCRRLVVAQSVRIVRVHHASAIEIIKKWPATRRKLVTTLLVGSYRPGDPAVLLPHPIPALGMQRLLAALPNARQIFLRNVHFSPQCHSLSSVYVPTSFRDTVDTCRFSLRLLRLDLTLAIQLDLVPHVAHCVISGRAFIETRTPILWNFHPPPDYTFGGIVAQHIAHLEIPTRRWETLVAAKLPRLESIFCTDDGRRSLLSLAHAGNLLLEARLQLSGHLRGAPVPTVFGGCPVFYEFVQPAFLKHLEIGDVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBG5</accession>
    <name>A0A2S5BBG5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBG5"/>
    <dbReference type="OrthoDB" id="2523646at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="53794" checksum="26F0B8BF3FF8726A" modified="2018-07-18" version="1">MDRFSLLPPEILSSIFSYLHTDPPPPLSRRLLPYSRAARLHTVDIVTIKQLVGFVDMLKAIRGAGALVKCFCVGLRETTETVLAFGEGTGLNDLLSAALALMPAVREMQAVDWMSTSFVLSDNAAESLCRSLRSLRISVLLAQINSSDFITYRLALLSRYPTLRAVEIMVLPYDPGSTAAMQFDLFPAQDLDPQPLEMVQISHVESLTLGGPLCDQRVVNVLRAFRGLREVAMYDSFASQHIAPALAALDAASLRSLRLQRLVTTPPPVTLPFQDTDWSRFLHLRELIIGMPIASDSLFSACPTFTSLEELRFGATSNVTVAQARQVLMHRPASLRLLELSNVSGDVGAPITPATLPLVGSWLEAVRVAQADTSEPPVPHFPLLDWRLPAWTEGFTPSEVETLFPLAREVGVELRGSAISALLTTFLLERQIDVWQEQLDGTRTGEDVDDEAREVMCRREFWDALALRYKARLLGTGSVMQQLNGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBN1</accession>
    <name>A0A2S5BBN1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBN1"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF23">
        <property type="entry name" value="DUF726-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="73188" checksum="D45D762779B7280E" modified="2018-07-18" version="1">MEGTQLESKVDTWPAELALVVAIAAKAATLHALRGRFDLVATRSANTSNDPSPSNSGTSTPTNVPPADVKPTKTAELNAKLVEMRERTAAEAAEWLARVCAHVGVDLGQLPDALDSKTKLSLPVRSDRQGDGAPTEEQLQWDTTWELVLVSLGLVGSAAANGQEDKPEQSKSSGLPGKLSSRVGLLFSSSSAASSTTASPHTASSQNRDPDSPSQPPPLNYTALSRSLISRTLDILSIPHSVLTDVEHTIAQFLYFQLQERNRASDAERETEQAKSQVGWENAAKEYRERAAKKGNALKWAATGAGFVLGGVAIGLTGGLAAPAIAAGLGTFGIATFSGAGGAVLIGTLLGLGGGGLAGYRTHRRLKGLDDVSFVPIQEPDAHEFPQIPSLTATIVASGFLLDEQDSVAPWRTYVRTSRADAYALKADPQTFLEAGRSLDKFIKNRLITMGGVEVIKRTALAAVYAGVALPLTIFQTATTAFDSDFTRCRDKAQKAGVLLAEILEKEVQGKRPVVLVGYGPGASLIFSCLEHLASLSLDSLVYSAILISLPASPSNAQWVRARSVVSHELVNAWSGNDWVLGIAARLFTLSPSIAGIRPVTLSSSNSSSGSSTGHGAEASVVVTNVDISDLLVRGHLDLRNRLDVILERIVDKRDEQPTGSGAADAERAKRALAAQDKEEEDLVQEMKTLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBP6</accession>
    <name>A0A2S5BBP6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBP6"/>
    <dbReference type="OrthoDB" id="5201563at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="142" mass="15367" checksum="B97251904C288564" modified="2018-07-18" version="1">MAAATSSNTSTATVSEGAIPSILLRSDAAAAREHQAHLIHGHEAHTQLSRRPDGLRGDREYHEVYEGGDPEGWPQARGVPPYRPLRSNDAASRPLGATAPERVFVTAMFTGVLTNHVIHEVWANTVGRVTKKTFVYPTGGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBY9</accession>
    <name>A0A2S5BBY9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBY9"/>
    <dbReference type="STRING" id="741276.A0A2S5BBY9"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="375"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="508"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="638"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="96068" checksum="03C344A0D41F0CEE" modified="2018-07-18" version="1">MAAPLPPPPPPGFPIRGPAQFPPIPPPWTQHTAPNGTPYWFNPITNVSTYVRPQPPPPPGFHIAPPPVMTTAALPALHYQPLVAPTAAAAPTKLKQPKEKKEKPRTKTRVGDSPWIRVVTNKGNVFYNHSETKESVWQVPDEIKDAVDELDAQERREREKHDEEEERRRLEQEEQAAAAAAAAAEEQAQNGKKRKADAGRDGGDAEQHEDLEEAAEEEEDDDDEGEERGDLDIEIEGGEARAVPDVTVPLAPDAELPPPTADAPDAETAPPPAKRAKLSPAPTGPGPETKDIPPQQSAAATAPRPTTKKPKKNKVVSSLEDLNDEDWQRQIAEEMAREAEEGPDGTSNATQVEEKVAAVAAAPVQQQQQQLEVDQVEAAALYTVLLSERGINPMAPFETELPKFVNDPRYHAVKTQRDRRDLFDQFCKDKIREQRAAKKRAAESGIKLDPLTAYRHLLATAVTSTRTHFSDFKRSHAKDARFREFGKTEGEREKEFKKWLRELGEKKREAAERADREFREMLSEDREIRSGDKWTEVKKRHASDPRYAAVNSSSLREQLFNKHLASLASGSSSHPTASTSNSASATSASASASTSAAKTKEDKAARAAASLREREEKVRLEQMKSARSAERARGHLGKDEAEREFAQLLVDAVRDHNARFDDVAPSIANDSRFDAPSLTPSDKRRLFDSHQQKLYRSRVGDVEALFSAHSPTLITPFDNVLPAISSDPHVVRLVGTDFDQLESLYSAWQARRTRQARDDFTQMLKENSILEHWGRMKKMDKREKGKLIGEEGVREDSEDEEPDSREMAEQIDLKAIHSVLRNDKRYLEFNHFPEDRERWVEDYVNNLAAPKTTVHQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC79</accession>
    <name>A0A2S5BC79_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2557</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BC79"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="108"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="803"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1289"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1289"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1309" mass="141500" checksum="21ACC90E4490CDE9" modified="2018-07-18" version="1">MFSGASTPQRTTRRSARASRAPSATPLVASQSPAPPAVARTLGSNLHTGSPAPSRRSGAAAAAAARSQVAVSEVGSAIELDEAARSLRTGATKGDELADKVLVRDEHYSITERKNLPQAVGRIIEASDPYTQPVKAVLDPITGFGLLVSNESCCVWNAASRAPSSTTYTFPLPPQAALPPNVKVFSPLPFASLVPSPSQTRQQQGQREPGLVVVTNTGDITFWESISLSLSGVDRYRSARAPLHPGELVRDLVLLSPTAYLVSTSQARLIAIDVVPGAGRADVSVRILERTVGWAGSVWSAVFGSKAVDPRAGILALAVSQPRAVQAGEGERTVYAVMEKDVQVWKVPVRGGTGGERLVAEMDLFAGILEALAGAKVGNEQWAMNEGQVEIVDAAVTADDRLAVLISHVHDATMAESRSHAIVQFEVGTGGGADCLRVAGLSHLNYQSRPDPRPLSTPRLSVGTGETAFVVFADAVVLVSLSNGESSPRFRWNRLDSSLEEAFPLRSNATRFIGRSMPAYLPAPPSPTETLSLLTSSATSLTVTVSPPQGHRLIASGSEGYKTRRLQTRLEQAIFFGTADAENPFAFDLQPETYEGDLATAAMATSAGILASSSSNMPAILDLRVQLADRVKRSKALIEFINANGLLGKLPRSARQQLSWDAEKLEAALALWQHHNARTVSGSNALGDAVLQYMDQVGEGFGEDPLRLFFRTKTAAVGAVLEIVSAQTKAFVDEQGRSSVEEKAARLLGANQALLASLHAVSRHRASTAKHYGLDYQPAEAEPWTARAPLLEAKQWQLQASELCLREASRDLGARSRDVQRLAGASATSQQLQGAQMDLRRQLADLADLTFTTFEERIAFLQSFMGDANAAEPRKLREQYLAVRPQVIQILVAHEQVSAAFAVAERHRDFESLVRLANDPKFGSAARISGYLDSHGRDFAYPLYTFYLEEGKLRALLEPEEAHRDLLTAFLDSTENDRLAWINDIAIDRFEHATEALTSEATREDSIAQKKVMLSLGKLTQLAQMDQSSLRGEDAQRELEGKSSCPHHSPEQRVLMDVPSIAIDDTLDVVRTQESLAALFSERLSGSESRLSVYEQGRAIAERIAPALHDRPMLAERLASACSSLFAGHVLSTEDLIDVLSLKENVNEQAGDFGMALDVLVRAKDLPEARRRSALAGIWRRVYIQDDWAALKGSMGLTDEEMAAALRNTAFYATIKAAESSDLPKSMYLEPGEAFSSVTPDEISARLPELAADAVQLVQQDYEQENSLLNEALQQGLEAYCQECLRLSRETEPDRSEAEALGGEAVMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC80</accession>
    <name>A0A2S5BC80_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC80"/>
    <dbReference type="STRING" id="741276.A0A2S5BC80"/>
    <dbReference type="OrthoDB" id="2585512at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="506" mass="56077" checksum="8C1830E0D7DB384C" modified="2018-07-18" version="1">MPTSIADLPPELLPELLAPLVARRDLYAICLVCRDWRDVGQRRLFNHIRLFGRDLAIAAQLFRTLGSNARLAALVRKLEVRVYPISLKVTEQAETERLAIAMLEKCFNCEELVWTRKGALTDSVWHAIHGMPRLRMLELNAHTNLSPGSWSADNLVSLRPLRSLSLILPDRNVANILPEFFARQNASSDEGGQLEQFSVLCRESPVVNNSVVRAISPFLARSRLASLALAGCSKLGGDPLLELLPGLPLLRHLALEACNLEPRFYVQIAPSLPQLESIKLTHPGPRHPSVASFFPAVESLLAALPRLTAFTLYHSGASSDGRREWPVLPDDFVRNIALSNGAVLRKFEVSGILCTVTAAEVLAKGAPSLRNLVLHLGSDFDLDRLTSAFSPLAHLRTLHLLSQRATVSLDAILELAQQCSPTLRQIGFRNRVWIVKRTYHAEDEVPKVSLGQYDLPWWPEALLVIRFYETAAAFGAFRRNRYGAESDVESEVEEASSASSDSESDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCI0</accession>
    <name>A0A2S5BCI0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCI0"/>
    <dbReference type="STRING" id="741276.A0A2S5BCI0"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015435600" description="DUF1748-domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19943" checksum="38DA32B83A9CA99A" modified="2018-07-18" version="1">MVLGRLVHYTLDVVLISTVLAGVKRHTGFQSVHQSSRFPLFQPLRACSVSGGIQQALLKAAPVLRGYGDGGHEDLSTRVVITRQSDRQRAKSATARSFDLQGIRRASVEASFPARMALRAGKKAKERLPIQDAQVNTGSMPDGPVRHTADTLLFAGDRVFDIVAATSFSSSWFEKETRKPNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD18</accession>
    <name>A0A2S5BD18_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein YTP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD18"/>
    <dbReference type="STRING" id="741276.A0A2S5BD18"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015428686" description="Protein YTP1-like C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="33"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="46"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="168"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="65120" checksum="048D4B9D924682F1" modified="2018-07-18" version="1">MTLTRSGRARPCSALTLLSLVVFSTLLTVVAAHDHHETEDVGPYEHNFTNDEPLDSVIQWHIGIQIFCWGILFPVGMILGMTRSRFHVPVQSIGIVLSLAGNFLGHHHAGRSFHMTAHAHFASYLWWYMISQAAMGVFLKLHVLEGSRVRKGVVVAHGIVGKSFPVVGWVQMIFGGIAALGYCFGDHLGQCLAHFIMGSAFIGYALILLIMLRLGAGFLARHKMSQEYLDSWVIMLWGIVNTFTEHNFLAAHPTGWSHKDMQHVSLGVLWWAGGALGIFLGRKGTRNIVPAIIIGMTGYAMANHGQHLEFSTDVHKLFGYSLMLAALARIVEVCFVLRDQATSESGRPRAWQHLPPYLLILSGLTFLSATEEQMQWVAGSGMDSTTYANILFSGAFAIYLVGNGLVEIYLYQTAGKDEPEESFEANMDVEDGGSGVGIRGRTRYRSTGAADQPTRGPGGLAAAIPAAIAGAISSLSQAIRSPNASRGLFGPAQETAASSRRHEQEMAQYEQVPLTSSTAATAAGAADGRRTVDDVGSGRRRGGESGALPLGSDETVFDVGDFQDDDDDDGGDGYWQDKEDEDSERQPQQQQGGLRRTARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD73</accession>
    <name>A0A2S5BD73_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2166</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD73"/>
    <dbReference type="STRING" id="741276.A0A2S5BD73"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="171"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="520"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="85899" checksum="0E6BE7EB88108651" modified="2018-07-18" version="1">MAPAQSKLASALPLRTRLEGGSGAAAIAATLLALVYLRRKVVQAAQEAAHTRNQAVLTTPQIELAQRELYNPLPGGARELLVPNRGRVSKVTIRPTKATTFAAHRPLFRRIAAPAVAARKAGESAAASANAAAQRVGVNKDFFRQLAAIWRIIVPRATCKEVGLISAHTTFLLLRTYLSLLVARLDGKLVGDLVSANGKGFLRGLVYWFLLAIPSVYTNAMIRFLQSKLAISFRTRLTRYVHDLYLDKNNTFYRVVNLDARIGANGADQFVTTDINRFCETLSALYSNVSKPVLDLVLFNIQLGRSLGGKGSIGLFASYFATAWILRKVTPAFGKLAAVEAKLEGDFRAAHSRLIINSEEVAFYDGGAIEKDILTRAYLRLIKHVNSIFKIRIVYGMTEDFVVKYLWSAVGYCLIAIPTLGKKQDGLSIPQRTENYISNRRLLLSLADAGGRLMLSWKDLSELAGSTSRVYTLLSTLHDLSVSSYASTLRPLDLPADAPFYDLGTLNGRLVDSAPAERGVSFDKVPIVAPAPGVARGGEELVKQLSMKIKPGEHLLITGGNGSGKTAIARVLAGLWPVWEGVVSRPTDAEIMFLPQRPYLSSGSLRDQIIYPDSYPDFVKSGKSDEDLLDILRKVHLAYLPGREGGYDVRKEWKDILSGGEKQRMGMARLFYHLPKYGVLDECTSAVSTDVEGSMYQHAKDVGITLITISHRPSLYQHHMYLLRLTGTGGRWEVSKIGEAEHSVSFQKEIQSLEAKLADVESWKKRLGEIDEQLHFKTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDJ0</accession>
    <name>A0A2S5BDJ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDJ0"/>
    <dbReference type="STRING" id="741276.A0A2S5BDJ0"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF56">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="34"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="345" mass="38800" checksum="E244385F7112D905" modified="2018-07-18" version="1">MPTQLTRESLATIPLCYATCSLGKSTDSLAIRLHAISRAGFSHIEFSFPDLLAHASVSTGRDVADDDYDTLCRIAEEEIRPMIERERLKVFILQPFGKFEGWKEGSQEWDGVEGWIRIMKTVGTDTLQVGSSDAENIDTSRDKLVSDLQKLCDRLEKDGFKLAYENWCWSTHAPTWKQAWQLIKAVDRDNIGYNPDSFQIAGAEWADPTQEDGLVAAESDGERDRRFQESLDEMAATIPGDKIYFYQISDAYRVDPPLEDKTIDDLRPRGRWSGAYRPFPYGEGYLPVEKVTRAVLQTGFRGIFSLEVFDGGKDGQGKDVNLAEFAQDAMLSVQKLLDSVAEDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDL7</accession>
    <name>A0A2S5BDL7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDL7"/>
    <dbReference type="OrthoDB" id="2504279at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="211" mass="22712" checksum="774B826E61F13AAC" modified="2018-07-18" version="1">MAISIDPSTAPLPAPNASVLASLKAYVQLVETRRSLQAEMDQALSSFLTGESAPLANGQDVLSAPGAPAASSSPSPSSLSACAAEAIRPPTEQELQQVLQIAFGGLVEVKEQARLLVVELDERWDRADLARMVRGIEEDESARIKATLERDQLRRLQTLQPELEFSSTIQEKEAARNTLASQIQEQVQDVHAEIADLAAAEADRETEDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDS7</accession>
    <name>A0A2S5BDS7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDS7"/>
    <dbReference type="STRING" id="741276.A0A2S5BDS7"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="130"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="578"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="739"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="826"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="921"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="852"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="891"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="954" mass="103924" checksum="8A02CE116051E461" modified="2018-07-18" version="1">MASYDAVDRVYSSSFGELTLSAVLDDLAARFIVNLPQDELESMDRVCFQIEQAPFQTAKGSKRPRADSLQNDTRHWYYEDFIRPNASNPSALPSYNLKAFSLLMFKSCPLLHDLVPQHARIWTSFMQYKERVPVCGAVLINEWWDKVLLVKGWNKGSAWSFPRGKINKQEPEAMCAVREVLEETGFDLTPYFPRAQLDPAYVEPEGQERTPYYVELVIREQKIRLYFVPGIRESTRFETRTRKEISKIDWFRLSDLPTWDRDSNHHHHHQRKGKGVGGGAARSKGELVNGKQAKFYMVTPFISHLKLWIDRNKPRNIPARTSNPDSPLPQPAYVAPEHQQQQKQKRQQQRQNHLRDFALPGGRQLQPWSATGEDEDDDHPTNHLPSDSEVTESTETEEDDEEDDFGGGPRHCPPGEEAAAAQGWTTTQQGTDALQALFFGGGDAARGGGGADDGETTLVHQSSFAAPPLHAFTVGHAAVTAGVPIRPLPVPYQSTSSAAPSQLSTPNSHRSQSQSTIHATPPQVAYERQQSFVQPKPKQSENHQTRLLELLTGSAATPPPPAGAGATTATTRLAGAMGGLTLESPSPLAQQLPLPSSHAPHGSYQYQHEYDHHSAAGPASSSYGYQAQQQRDSLSHLHHHHHPDLFSPDPIHGSPASDPVPMTMSTAAPVFVSDLEESQKQEKRDALLRALLSVAAKSPPQPPPRESDPHVVAVMAPPLPSGQQEHEARWYAQQVPPPVASTTGPAPNGNGNGGGGGGGSLLSILNGNATGNNGGAPPPHPRAAMPSFGVEAPSGQYTLGNFQPFSPVPVHQQHPHASIAQPYPPLHAQQQYGPASGMDGRPPMQALHFPHQVSTAQQQQPPYASHQPAYSQPSFPPVPIASGPPLHSMLPAPPPQNYPQHGQPPHPVVPQLPLSLPTMAVQQQQQQYRAGPPAAQQQGQGNAGQLLGLLNGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEG6</accession>
    <name>A0A2S5BEG6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEG6"/>
    <dbReference type="STRING" id="741276.A0A2S5BEG6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015676441" evidence="2">
        <location>
            <begin position="19"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="159" mass="15933" checksum="0B22005AA24C66AE" modified="2018-07-18" version="1">MQLAHVSLLVSFASLATAASLNISISLPIKQCGEVDVNPFCGEPPCTISLRPSNDTSAELDGDVIVSDGAVGYSTFPEPEGSNLTFWIVDNSGQSNHSEPFVVQSGDSACLASRNGSDSTPPSSGNGNGKSSTASHATGGTSALFAGAAAAGLGLVFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEI0</accession>
    <name>A0A2S5BEI0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEI0"/>
    <dbReference type="STRING" id="741276.A0A2S5BEI0"/>
    <dbReference type="OrthoDB" id="3239304at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27467" checksum="EC4C2D686C8A4B7E" modified="2018-07-18" version="1">MEPYIPFTAAQVRRHRFCFCVPVRWGVWILSAVEAVVSAMLCTANFLALFSTHDGRPWLIGIRVAGVLGWGSCVVMCGFGWIGTIEQKRKWVEWYYLLCWWHVCVIGIFGFISLLLLNLPGARIVAQGACVTVALAQKQLLHLAQKVSTEEAANVVATCERTVQIGLILSDLAWAIAVVLELWLGLIVGHYLDELADRDAAIHYGVDIESAQAPYSLTGLPGGTEIEKKYRSTGKRSRRSRRHERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BES2</accession>
    <name>A0A2S5BES2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_1635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BES2"/>
    <dbReference type="STRING" id="741276.A0A2S5BES2"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="50"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY75265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="426" mass="48464" checksum="1509007D2C30A5E0" modified="2018-07-18" version="1">MSSYLASFLGRGKQTAAGRDGVENATMPASFYTSEAVWRLEQRAIFSRMWLLCCHERFLDEPGKYQLMNIAGLSFFVIRSKDGQIRAFHNVCRHRGFPLLDPTPEGAAEPAETKGKRSILACMYHGYKFQTDGSLFRAPHFQEVPGFDPKEHSLYPLRVHVDANGFVYANADMSDDALSWSDQFGEFDKQERLQKVEWEDYNYELSWSMENAPYNWKVLVDNYSECLHCPFTHPGFVKTTDLDTYKVEGSKGIMAHSVDAKPGALTPGTDADKFAFNFISPAASHTITPMYWYHMRIVPITTRTCTVLYDVYRHKDCTDEVFKENHDFFVHVESEDKMLCANVQRNLERGTYNSGPLHPDRESGVIYFHANHLKTLRDHFDKEKQAGREIRGGTHLYRGKETEADAFASELESCGGSCAGGAAVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BET8</accession>
    <name>A0A2S5BET8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BET8"/>
    <dbReference type="OrthoDB" id="2529953at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="531" mass="57755" checksum="30755B1B6A33E080" modified="2018-07-18" version="1">MADDELDPAFLDLDLPTLGSSSLQSLGAGFGGISLDSSRDDDDDDDEQEDSFAAQLGAGFGSTLSDELADLSGFGSSRRDYVSDSGGEVDDDDEGPRRVHDSPSRAVSDDSDSSLHRAPRRRRRVPSKQRTQQLASTATLAAELAADDGDRRPERERALLQELGLGDDDAHNDASGKRASGSATATYGASKASSEEEEEDRELSSRGENGWQNRAGRHRSRPSSRNAGIGARSGPHVLDSPRQEEEQDERREWALAEAVNDVAGATEQSTTDIDAFLQRLRAYTTNFETTDERSRTGTLPPLGSATASNPPCTDEPRAAAVLYDRQSIVEDLSAKLLRNLQLSSAKRDDELRDLAVLERDLGRTDPSWRNALAFLDPLDEDGRNEAHDFANLTVPVDPLDDDISGRPAGDLEPSSSDLVTAIASDLSSLRLATQSLLAIFASLTEQTQEQSALASEAGRKLRAFRTQLSSIRDDHDGVQRSEAFVRAHESRWTGQADSGQASNRVRQDVDEIRVRLDQGWRQAQELLVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF01</accession>
    <name>A0A2S5BF01_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF01"/>
    <dbReference type="STRING" id="741276.A0A2S5BF01"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="249"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="428"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="828" mass="87600" checksum="E27628361FF86247" modified="2018-07-18" version="1">MTTTTGSPPATVTASDDLLLAESLVSLSLNTTTKAVARSTPRTPARTAVLFQPACTKHRYIRTRDTSTIVERPERIRAVKTGVAAAYARLETALPAARDDDDDDLDALLSGLSLDANRDLKGKRRARELVDPRGPFDILDSGAVMSVHDPALQYIHSKPNRAPQDVDAAAAQEDQGWESASSSSSAAIPSTSAGPSASAVDSKPPRASTRPVPWPEQLQSLCRASSSLLSSQPSLAPSSSSRASEIPSHLPQGDLYLCPGSEEAIFGALGACCEGVDRIVRGSRESGAGHASAQGSDSSVGLYDRAFVAIRPPGHHCGEANPQGFCFVNNVAVAAAHAHLEHGIDRVVIFDIDLHHGNGTQEIAWRINANAHEILESRERARLDTAAASASRTLPRKSSPRKSGGSTLIKKEEEEGTAVAPSERNPLRVMYASLHDIWSYPCEDGDPSLVSAASLNLNGGHGQFISNVHLEAWTSERNFHDRLYPRYRDGLIDRAADFARSTRGANETTEEAAAQTLVIVSLGCDASEHESTGMSRHGRNVPTSFYRRFALDAVAFARQHAKGKCLTVLEGGYSDRALASASAAFLAGFTEPDSSSFEEEARHERDGWWTEAQLKKLEKACAVAKGRRAVATVGSPATLLAGADPSADPWLARAVEVFAHLEDTAVAPPPAGNSLAATRSGVESDPNTPRQLRDRKPRAVNYAQLADVSPIPSPARGPTAVRRSASASRLRPAKDETPVDGVLPPPPPPPPPVPSVPTAFLSTGRVAATSSESASAAALLAAAFGNVPSTTFIPTSSPSAEDGGDKPLPKPSIRFTWKQGGFGGEPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF79</accession>
    <name>A0A2S5BF79_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF79"/>
    <dbReference type="STRING" id="741276.A0A2S5BF79"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="339"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="764" mass="82421" checksum="7DD10CCBC24C5BCD" modified="2018-07-18" version="1">MPRWKGDDPAPRAGPYTDSRPFEPAVDAQYDRHLDAGAQPFMPAVYPQQPPPVPLDGQYYAQPYAADLYGPAQRGWYGATLSGAEWMPSSYAAPPVAGTMNWGPFQPSHPSFYPAPPHPAYPYPAQAPPGLGDHRDDASAGGPDPYHGYRPPSERHARDYQGGGGGMFRRDRWQAPPQQQHQYQESGWANHRHRNGGSRSPSPAPYGDPAGRGAYYPRQEDQFAAEGAMAGPHSRRGPRHGRYSQRSRRFPSEVDAQPGASASEEDPHGYGFGFGGLQTASAAPAYGPDGTYIPPERRQRRDLRTAIVSPPTPTYLAAADLPSTSSAGQDSGTQPQQSEPVTLIMDLNHTLLCRAKRNRYASKMPVVRPYLSTFLTYICTTEPNSPDGESPPSTRQSSRRRKFDPIVYSSARAPNVLSMLAALNLIPPARLAALPFRATYEPAPEEGDVLRMVFTREMMGLSERDYHGDVETVKDLAKVWERLGWAGDGSKEAVVQGTGAEDAAVAPGEAVPEVEAESGGELTAGGPQAPETAEAIDGTPVEAAAPPKKLNKKAKLRRATKRDTTGASRTLLLDDEAGKAAQQPFSHLPIAPFLLHPSEIPDPNAAAAPPPQSDADVTVDGAQSRAASPPLPSASAPRTPFYDSAAVALQVDSQHPPAHDKHLLATIWQLERLRFETNLAGAVKSGALDRLRDEARQAVIARRKDVAEGQAAAAETADDGDAVADYEIEDEMAQRGVAVCRELGIAVTREWAPDWRDTLLASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFB0</accession>
    <name>A0A2S5BFB0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFB0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="162" mass="17627" checksum="D6424AC7B8A16683" modified="2018-07-18" version="1">MAVGAPAIVGGGATPHWTTTTTFPSKSSSTTSPSTPATSTRVANVLCIVIPLVILGGLLAAGAVWFRRRRRLRRLAAKSRSSVFVQEEETQSNRSPTDPARILFELVVVLPPGRQQIKHDVRTGRHKYSLRTRTSAVTLTTTYLSPSCLSTLSAEELSRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFI3</accession>
    <name>A0A2S5BFI3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFI3"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="8">
        <location>
            <begin position="221"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="478" mass="55197" checksum="C5F3D7D4E609A3DC" modified="2018-07-18" version="1">MRTNPRRAGKRGAIVYGDIRETPRRRDCLLDASLQFPLTFSTARVANLCRPAMASKSEPPRRRAIGDGVYSSNNCIGKAHFGPELDATRCHFQNVCIELQKPVRPQQWDYAKDWKPEQSVNMTYYRPATARDTPHYSDRKHEITKPWVRLHTDNYLIPHVVYEPLPADSVWSPAEHAILQESFWPENFGHSMGDDFFSAFHLAQSFGIWDRSDIQMIMHPACWDRGYKERGCAHHAEFAPYILDRPFETFNSTLFASQAGGRVCFRNLYTGMRRFGTGFPSENILPPFVGELRDTAGLERSPRPRRQRITVFLKHGRRVFLNNEALVEHLRRRFDVEVDLMDPAELSISEQLAYLQDTTVLVSPCGGLSYGGLFLPKGSSMVVADYWHMEDKVYNDTMPMEPFVFANNNDVTTYYYPLEWKDVQMDESVVPSWEGKGDFIHYRNWANVTINLHRMSTYVYSALLTAEVSQGWQHSFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG32</accession>
    <name>A0A2S5BG32_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG32"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="174"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="520" mass="55647" checksum="ABC01F00FE92299B" modified="2018-07-18" version="1">MDATELNGGRGAAPFHSLGTLVASTASHPGQLRTPDNDDDDDVDHSYVYISTAPSSSSTATSRAPSPALQPLPPDWPVPKPRRPQSISQTPDHFAQRLEAQVQHPDARPPPAPRLTHSPNPNLFDSKWARQPEPALPLVSLEQWREGLRHYARTASHPRTYIHFVRSLHPSLVALFLVSVSATLSNKTLLRGFFEGLTYSLTTWQLACATLGTMLAERIGVYRPQRVPTKHIRLVQAVAFVFSCEILCSNLALRLVPVPFHVSLRAASPFLTLVLSVLFFGEMTTLTTTSTLLVVLLGVALTSHHEAWLSTGSLLLSASALLLTAKSLLVAHVLESRLHLAPLDILARLSPLSMSHCAVFAILNSEPRKLWTFVRGSECTGAHVAQVALNGVLSFGVVVLGLVAEKRTRPPALAITAHAAQASTILFSLVLFGLRLSFLNCIGVALTLAGGVLYARFDAQDKKDRGTTGPVDGLGGAEHGRIGFLGGGGMGAGDGDSLPMTLPGSTAAPHRPPREKVAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG45</accession>
    <name>A0A2S5BG45_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_1346</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG45"/>
    <dbReference type="STRING" id="741276.A0A2S5BG45"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="14">
        <location>
            <begin position="623"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="460"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1028"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="309"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="482"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1052"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY75723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1096" mass="114422" checksum="285AF10C4B97E08D" modified="2018-07-18" version="1">MASAAATRPPPAPLSVVAPHPPHASPQQPPPSKIPRSRSANSLALFRTRSSGFEARLDNDEPGPANERGGIRRVGSYESTLSASPPSPEHDSSGGGASERHAHVPAGTATSTPLPRANGKFAKWLSRSIGPGSGGSPGPQADSISNLNDTIQPSKEVPSKNGRPRRSMSIGALDLVSLQPSNTSPASTAPVQSPAAAAAFSAPSISISSSPFAPQPGSSAALPPTAATTTTTVAGRSRRLLPLGVGGGLRADAAGANPDPSQEVPSDSSGGGAIKKKRFGGKRSQSSGMTLNSAQYQGDDVGSSELRISSSRSSSASGSTTRTTTTTTTSGSVGRASVGSATRDPFAFSSSSSSAATGGAAAEGRLARGLRKTRSGLKLFGRARDQEAGAATSAQSSSTVERTQSSSHRPSIGSTESLASASTATGDAESIRELQQRELQPPLASSNRLGGWFTSLIPSANATTDAGSPDKARRAAADQGTPGRTRGGSAPAATGSPTPASPARRAGQLSSSSPLKKGSSSSASIGGGGGRLGPFDRMLDRAVQYFLDSDANTDRCEDDIWLLGVRHDGWREDAVDDEDADRAGGKRSRSPVKARAPAIPARGDENDVFAAPASTTIHGWPATFYRDFYSRVGLTYRSGFPVIECEPPASPANGAGGVVHGMLSNLSMSIGRGAQRFANVAAQADSSEPRGLSSDTGWGCMLRTGQSLLANALVKVHLGRDWRRPLPASLASTSSIPHAATYARILSLFLDDPSPLSPFSVHQFARQGKLLGKEIGEWFGPSTAAGAIKALVNAYEPAGIRVVSCVDGTVYESEVVEASLVDGQAWKRPVLVLVNVRLGLEGVNPIYHEAIKGIFRFPQSVGIAGGRPISSYYFVGSQADSLFYVDPHFPRPAIPLVLPTESDLVDSFASEPISASHPQLDEFLLRAYSDSAWATYHCDKVRKVALGNLDPSMLLGFVIENEADWSDFRARMQDVGLQFLPRVRQFEDLSSKTATMFTIAASPPAWLRRSASSAHAARTNATARTSLDDSFSVVGETDRDHDDNEVNSDGFSEPDDWELQSTDDEAMRSSAVEVRRDSPAADSALSRSPDDLVIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG65</accession>
    <name>A0A2S5BG65_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG65"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="332" mass="36760" checksum="B860E694EA3D61D8" modified="2018-07-18" version="1">MPKVVPLLLARPDLLARVRRIRIYTGVSKSLDDLHATYASFMLSPDFEGLVAILQTVPDLRCLRVPAKPPYAMLLAVAAAGPASRTLRALKLTILPASTGGELDLTRIWNTIRQLRDLKSLEISTTCDARVITATILEGEILRSDSFGLASGFSTPRQSLVNAVSRMIDLAYLKRLTLCFGEGATSSPINLSRRCVSLEQLELWGEEAEHLLPPYLALNDAIGGLSHVASLNIRHFDGSSIESPIPFEAFIKALPASIRQCTISSFYLDYVLPEMGAFKRIMGRFPSYSIFVVKPRLRKPEHQRRLARPTTVNIRCPVRKESRAKGTHPVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGI7</accession>
    <name>A0A2S5BGI7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGI7"/>
    <dbReference type="STRING" id="741276.A0A2S5BGI7"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="170" mass="18393" checksum="D721695B35478D50" modified="2018-07-18" version="1">MTMSLDRSDQYDPYIPGSNPNQPGGGPGPAASTGGASGSKTQDIQREIDATVGIMRDNITKVAERGERLDALQDKTDNLAQSAQGFRRGANRVRKKMVRPQATAFVVPELTPLSPRSGGKLCKTVRPSYPYLTKVLHGRPCRKDMKMRVLIAVAIAVLVIVIVVPIVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGJ4</accession>
    <name>A0A2S5BGJ4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGJ4"/>
    <dbReference type="STRING" id="741276.A0A2S5BGJ4"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015441244" description="Acid phosphatase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="49978" checksum="C8FF27D3B476A6EE" modified="2018-07-18" version="1">MVALALLAGALAAAPAYAAIAQSFVPPAANPSSTSTNYVGKNNGTIHNSPKVTGKAFDRFIQIWLENTDFATAASSPTFQKLAQEGLLLDGYYGLTHPSEPNYAVAGLGDFFGMHGDSFSAFPKNTSSVVDLLDAKNISWASYQIRYSIYPLLAIPYALTAASTDSLSISAPPDYVRKHSPLILTDSVAGVPERALRHRNFNDFAVDLNASALPQWMFVTPNLVDDAHDSTIDFTSSWLEYWLVPLLQNQNFNDNRTLILLTFDEAETYTQPNQVFTLLLGGALPQQLVGQKDPSYYTHCSTLSTVQANWGLGSLGRCDTNKTLANVFEFVANATGYKNNGLTSNSTKLPMTNLTGVFPGYANTEMWTPVLAPNVSAVGAGGGSVFVYPGTNTSLTSWSPQNLTAMGVTNPISIDPGYDYSNGSLVTAAAAPSSSSSKTATGSIAAATGKSAATSFAVPAMGVLVAAAGVAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGR3</accession>
    <name>A0A2S5BGR3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGR3"/>
    <dbReference type="STRING" id="741276.A0A2S5BGR3"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="56"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="406" mass="43815" checksum="82D48741068E82DE" modified="2018-07-18" version="1">MAMFNRNSLPEEFEAEHGSVDLADGDRKPASGRSGAQQSPHDDREDEDLDLGRAGQRVWLCKVPRFLLDKWQQSSREGEILGRVRVYDEKTPDGNAKISVLLNEHASTSGNGAASTSASTSEAKPDLKGKRPAHLAAAQAGDGLPTEYKLTMQNTASKNLYVFGEKIEDDLDTGEEGARKKRRVTSLLGTVAHECSLTPVITNPAAAAAYARIMRERQRKASEPKRTLKRLEVDDATANRMASGVGVGGIKARAATFANTTNKRKGATNAAGQPVRAFRMEKPQLLDALISHFQSAPYWSLKSLNEHVKQPQMYLRECLSEIATLIPKGPYANMWTLKPEFKGTAGPSGASTSTLASASLSTTGAEDVKPDFAAAAIEGGVKKEEGVDDRLGDEEDDDDGDLEMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGT0</accession>
    <name>A0A2S5BGT0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGT0"/>
    <dbReference type="STRING" id="741276.A0A2S5BGT0"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="523"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="573" mass="63555" checksum="89F8171A08F5D258" modified="2018-07-18" version="1">MSLSTHINAEKVLKAAREHSHKHGHKSAHELMGRDKPGHYDVPPSADRYDTEPIPKYSIPSKGVPPSVAYELVTSELALDGKPFTNLASFVHTSMDDYGDRLVYENRAINLIDPATQMIHARLVSMVAKLWHAADQGENATGCATTGSSEAAQLGGLAMKKIWQDRRKAAGKSMYEPGPNIVMGANAQVALEKFARYFDVEARMVPVDASTDYVMDPKRAMEYVDENTIGVFVILGSTYTGTYENVQLMSDLLDEYEQKTGNYVPIHVDAASGGFFAPFATPSLKWDFQIPRVVSINASGHKFGKAYVGVGIIVWRDKKHLPKDLVFTLTYLGSVEHSFSLNFSRPAAPVIGLYYNLLSLGFEGYRRISLHDAKNARLFSNALEKSKYYKVVSLGHRPKEASLTEKAKELVGAVDAIESYIPTLPVVAFKFSDEFVAEYPRVKQVSIQKMLRQREWIVPNYDLPPNAEKEEVLRVVFREKFSEGSSSSQLRPLKEELTDVVADLTERLFSDIIEITEQLMEEHKAEVPHPGQGSGRASEGKHESAGSKSGTIHEKIASSHGEGTRPTGHDSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGY7</accession>
    <name>A0A2S5BGY7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGY7"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015696817" evidence="2">
        <location>
            <begin position="17"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="265" mass="24644" checksum="5DF1D0173E317F39" modified="2018-07-18" version="1">MLRFACIALLAVSTIAAPLPQAGDADVAPQDPASAASAGEPTIAFDPSSFSSGPDFGSGAPDGGSNDGTASTPALGGDLTSSAGNSTSLPDVSADTFGGINDLLSGLTGLQSNAGTKGSDDAGTAAELASLTGSAPSSDPTQAVETDAVAELTAGPNLEGATSAIGLLAAAVTDSSTAASPSAVASESAISTDSTTAEPASATLTPSAAGAGNATTSTTTDAVTATAAADPSSLTFDLNGFLAGASFDPAATAPAAAVAAAASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHB7</accession>
    <name>A0A2S5BHB7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHB7"/>
    <dbReference type="STRING" id="741276.A0A2S5BHB7"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="76"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="276" mass="31412" checksum="7FBD37CCCBF41CE5" modified="2018-07-18" version="1">MSASQNAALAQMQGDLKTLGPAGYYDSDRHDSATLLRFLRARNFDVEAAKTMWINSQKWREAFKVDELYESFVSTEKAAFDAFYPRYFHKTDQGGRPVYFQELGNLTFEKVGKTTTSQRLLQSLVVQLEALEREKLPVCSQIQGHLVETVSVVFRLQGVQWQNLLPMMMDIRKTIMILQDNYPQRVTAVGAPYLFPSFWYMVKPYIAPATHDKIHFIGHSTDFLAVIPAASIPADYYHGECHCPEGCANSDAGPWHGKSKEELREIERKVRSSMCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHF9</accession>
    <name>A0A2S5BHF9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHF9"/>
    <dbReference type="OrthoDB" id="10407258at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="387" mass="41925" checksum="AA92281988B0AF91" modified="2018-07-18" version="1">MAAHTTPRASAHAHKSGGKKRTIKEEIEARLLKERQHANRKEFRHYFRSVIAQPRSGARNVEVRPEFTATISASTFEGTKPGVLVYFGAYDRKGRATGEEWNTTFEGTADLIPKEFRSSLFSTKRLRTHSDDESSASESEEEEVEVDNEDEAPQSSAKGKGKATAREPKKSERRVPSAPRQARRAPTTTTKRVRRAPVSTPAHNDDEDENATQESLLGQIRPDQSREPLVASTSGTRSTGSSADAAASGPIPVEEEEEQRSLGRGKRITRGLYGRPRKAPTASHYGPAFASTTEESSFTFTTPAFQASPRKSPRSIGGESELARLCAQVDDLGVASSAASTTMETDTIRGSPAPEAAARHEPDRDATPVASSSGMTRSASKGESRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHR8</accession>
    <name>A0A2S5BHR8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHR8"/>
    <dbReference type="STRING" id="741276.A0A2S5BHR8"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="392" mass="42609" checksum="0FB5D4818390CAFC" modified="2018-07-18" version="1">MATSASTSYGPHTPAPAGKGAVGIAQSRGERPYQEDAYAVHSLVVPQSALKWNVVDDRLGTGWTPQTLEGFEGEQSPGEENKRQVAYFGVFDGHGGDTVSRYLRDSLAALIEASRVDEIPAIIDEYRSLGGYLKRYRGGPLDRFRKDSPEYSDWKGMALDDLAVLAFLKADCHVCADPKMKEKGGSTATIALLHSLDLPHSHPYYASSLLSLTIAHLGDTSALLASTQSGRARRLTENHHADSRTESERLRTSGTGIITDSFGESRWGGVVANTRAVGDAEFKPVGVIAEPDITKRVFRGDEFSHLILLSDGITDSLSDQEIVDLTRGFRDPAQAAKKIVSFAEDIGADDNLTCLVVPLPGFGRMGGMDTTASRREYRQRQMSSASSRQKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHV6</accession>
    <name>A0A2S5BHV6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHV6"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="361" mass="40532" checksum="A4A17BF98DC1ECDA" modified="2018-07-18" version="1">MTDSIPKDPWHQVTLSRDEATEYLDRIGLPAAQTLQQPPSLDLLARLLQSQLETIPKDTTPMHVAEQLWQPGSDPATPISLTSALDNMPEGILAFDRVIRQRKGAFCFAVNPTFSAFLRAFGFRVSELVGRTFKNLNNDPVTHPDGFKWGTFTHGFEVVDWPGSEKRYLVDAAWGPWACPVPIALENGSTVIGLNPYEAFRLVHEQLPLGADQTQPIDSQPGWTMYRLVRPDPSTAATPLSLPLPSDKVLRAQGSFWTPQFHFHLVSVPLLDYRLYHHFSASHAVGSFYAFFLVTRLLPGTGGARRSLMYTDKEGQPRRAKVFTTGGDEARGSLDSRDVEWVDMQVGPMREYLEKEFGFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BID9</accession>
    <name>A0A2S5BID9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BID9"/>
    <dbReference type="STRING" id="741276.A0A2S5BID9"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="242" mass="26770" checksum="7AE8105E8D6C67BD" modified="2018-07-18" version="1">MAEQTETPTWNGIDLVENRRRMERGELYTAFVPELTKERRVASQACAKYNRVATEVTRREQVELFKKIVTTLPDLPPAKEDPDEDEAQLTAFPWAEPPFKVDYCGRIFIGENSFMNFNFIVLNTCEVRIGSRCLFGPNVSLFAGTHPLDPAIRNGTAGPENGGPITIGDDCWFGGNVTVLPHVTIGRGVTVGAGSVVTKSVPAFAVVVGNPARIVRKIESEWANEHFAAHPEEQWEVPTTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIH8</accession>
    <name>A0A2S5BIH8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIH8"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="199" mass="21583" checksum="BB16B6E6E098B98C" modified="2018-07-18" version="1">MGAGASKQAAKVKPTRAAATAQQPLAQRMPSPAASARPQPQQPPPKASETKSDAIRRESEDPDFARNLAALGQVKVPTPGSAYMPRQDNAMLDILAERQRVDEIAEQTPAHKVRNLLSAGTLAHLFDERKACTSQKELDELSREFGMDPEIVERLAKHVNTPSISKIALPTKDANDTPKQLARWVDPPLTASEQPKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ08</accession>
    <name>A0A2S5BJ08_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ08"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ08"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="275"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="377" mass="41519" checksum="127695FD6DE7A69F" modified="2018-07-18" version="1">MSRDRLREARSQQQGAYGGNQGYGQPQSGYGGGGGYAPQQAQQQPAYGNQGGYGGYNAPPPQQQYSPAPATNQYQNQYAAAPAAYGNGGGDAYAMQTVNGAGSQSLIGSDMGPFFAEVEAVQDQIKQLHQNINHVSELHARRLASTDDMTQSTTGQQLTQLTTQTTGLTNTIRNRITVLNDANRKSPQGDPGFNTRKLQIANLQNSFKRALEEYNLVEKRSREKYRDRMARQIKIVKPDATDDEIRAAWDDSQGGAQIFSQALVSSRTQGARAAFAEVQSRNQDLRKIEETITQLAQMMQDMATLVLEQDESVKMIETQAVQVNTDVENGLQQTKKAVKSARRARRMRWACFIILLCIIIVVVVVVVIEVLKNQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ78</accession>
    <name>A0A2S5BJ78_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ78"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ78"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="44"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="537" mass="58611" checksum="CDA4D351BC723E69" modified="2018-07-18" version="1">MSHQLEPTYSKNDVEKGDEVVITQNTGTDGPPGESLHRGLKGRHVQMISIGGVIGTGLFLGTANALRHGGPAGLLIGYAAIGSLCYAVMVSLGEMVAHLPVAGGHITLARRFVTPALGFAMGWNYWYNWVIVLPAELNAAAVLISYWSSANPAIWITVCLVVAVLINLGGARAYGEAEFWFAIIKVLTIIGLIILGIIIDCGGVPNGEYIGGRYWHNPGAFVQFLGIEGAKGRFLGTWAVLIQASFSYIGTEIVAIAAGETKDPRKTLPRAIKNVYIRVTVTGLLVPSNDKRLALGTGTAVSAPFVIAIQDAGIKALPSIINACLLTSAWSAASSDLYTSSRALYGLALNGQAPAFLKRTNRWGLPYYCIAVGVAFSLLSYMSAGSKNAGTVFNYFANMTSVCGLLTWWGICLTATRFYAGLKAQGIDRRQLPYRAPLQPYLAYYGLFFSSVVLFFNGWQVFVRGQWDTSTFVTSYFPIWFFPILYGFYRFIWRRNERGPSKHEMDFVSGSREEQFFEDREEPEAKGVGRKILAYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ86</accession>
    <name>A0A2S5BJ86_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="10" type="ORF">BMF94_0074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ86"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ86"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="245" mass="27418" checksum="64454608791D281F" modified="2018-07-18" version="1">MVLAPPTDPSHPNDHSLIQHQNNPTHPAYLIPELCRGFYKLGWVTGTGGGISIRDGENVYLAPSGVQKEKIEPEDIFVLTLKTRDFLRWPVHKPLKQSACTPLFYNAYDMRNAGACIHTHSQHAVMTTLLWPGKEFRISHQEMIKGMRVGGTGAALSYLDTLVIPIIENTPDEEDLREGMEEAMRNYPDAPAILVRRHGTYSWGPDYEKAKGQAECLDYLLEVAVKMKLAGMDCEGLDQFAGQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJB9</accession>
    <name>A0A2S5BJB9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJB9"/>
    <dbReference type="STRING" id="741276.A0A2S5BJB9"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="614"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="900" mass="97755" checksum="59C5DE28DBCCCCED" modified="2018-07-18" version="1">MATPAPPPPIATTSSSRTTYPPPPPAAERPASTKSATDRSVTDAEGAQPPPSKSRRALDKGKEKLKKWVDYEPHVTEAAPVSELLKRSLKINYPKAAGEYVARLFPFTRWILHYNVRWLIGDLIAGITVGLVLVPQAMSYARIATLPLQYGLYSSFVGVMVYALFATSKDVTIGPVAVMSLEVARVIQSVQSSPDGAQYSAPEIATALAFLCGIIVLGIGLLRIGWLIEFIPSPSIAGFMTGSALNIAVGQWPSLMGYSNKLNTRESTYKVIINSLKLLPETRLDAAFGLSALAFLYIVRWALQRVERGSRSPTIKKLAFFALTLRTAFTIIILTIASYLLLRNKDPKNYPISVLKTVPSGFEHMGKPKLPTHLLSLIAPQLPVATIILLLEHIAIAKSFGRVNNYKIDPNQELIAIGVSNLVGTLFNAYPATGSFSRSAIKAKAGVRTPLAGWFTGVCVVVALYALTGAFYWISSASLSAVIIHAVLDLIASPRQVYAFWKCSPLECLIFVLAVLVSVFSSMEIGIYASVGASVALLLFRIARPRGAFLGRVRIRPDVASPPSYASAQDGSDGEASPVRAPSPPLPAGIRDVYLPLLPDGVRNPLVQVDPPPPGIIVFRFEESFIYPNASMYADMILEYAYKHTRTGEDFEGAKAGDRPWNNPGPLRWRTKKASKRAEEAEAQELQAEKPILRAIVFDMSSCSNIDSTSVQNLVDLKRSLERYAGDQVQFHFATILSPFIKRALLAGGFGTGVGWSGAERPLEIAPVVQGGMEPVMTEHAKRVQRLHFQRRLIPTSPEPGTPAHLLPKPTGATGEIEEVREDRPSTSSSTDRDLSANDLEKALQDVEQQGVHVGGSVWGHQIPGHESPHLEQPVLSTSFPRFHLDLTSAVAAAVGKDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJE4</accession>
    <name>A0A2S5BJE4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nop52-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJE4"/>
    <dbReference type="STRING" id="741276.A0A2S5BJE4"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43567" checksum="1A280CB5F732FB45" modified="2018-07-18" version="1">MSSTLGRSAPSTSSLPPAKRQKKRSSTLSSSAPPLGKFLASSDKSTRDKAVASLSRFLSAGRLNHLGPLAAAQAGDEDLQDDAEEEELPVGDLNWDDEYEVDSRLAPLEMAKLWKGIYYCYWMSDKPLVQQALAQNLADLTLDVRPRSKTRNGRVERFRSALAFLRGFWEAIVREWSTLDHHRLDKFLLLIRRFTHVGFRLLEREQWDARAIDEYNAMLTGPGGPLDVTNDKVPISLAYHLFDIYLDEIERLVTPSDQDAASESDRSLPLLPLLGPMYTTAARAPLQIMFTRLVDNVFTPLLDALLPPKPEPRAKRRRGAAGRAKDPAYPGIRASAVEGTGVEDPSAAAEVVGKQVLKRLFEEGGQEETGETQRRRIYTFVTARDVDFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZ08</accession>
    <name>A0A2S5AZ08_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_7107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000176">
        <property type="protein sequence ID" value="POY69893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZ08"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY69893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="36" mass="4010" checksum="C23424C68DD377DA" modified="2018-07-18" version="1">MPQWHYSLFRVTCSLCTAPDPAAAHTVSVRSLFCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZF7</accession>
    <name>A0A2S5AZF7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_7065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZF7"/>
    <dbReference type="STRING" id="741276.A0A2S5AZF7"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY69933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="501" mass="52110" checksum="B09EEA612749EB5C" modified="2018-07-18" version="1">MDPSAAPAADAVAAPAVQPSSQAAQSEAVEAAMSTPSTVLDDSSSNHNNHANAAAETAGGLQVASADVGADQAAPEAVTAPLAESAIAAAPVPVQASESAPAAPPASTPVFDVGPRHPNDAAPGRITKGGALLTGGYLAHKIYIGPCQCQLKRGFGFVEYADPAHAAEAVAKYNEGHFLGSQIKVELSLARTDLPKESLQQLKGQRNDRFDRKPHGAGGPRGGRGRNGAGPDRYGGAPPPGYAPPYGGRYDDRAPVERGYGAPPPPPPRDERYSAPPRPDYRSSAPPPAPYGAPLDRPPYDPYYAAYPPAAAVPGYPPPIAAPYDRPPYAAPMPVPVSAGPRDPYASERYPPAPGAARSPVMASPYDARAGMPPPMPGAGYAPMDPYGRPAPLDPMASAPYDPRDDRGAGARYQPYPSRDERYGGRSPPRGAPGMERRRSMSPRRGGPPPDPYARDPYASNGYPAPYDARGPPPPAPYGAGGYGGRSPPRYPPVDEYVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0D7</accession>
    <name>A0A2S5B0D7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="17">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BMF94_6832</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="17"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B0D7"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF153">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1247"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1275"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1326"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1360"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1390"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1433"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1212"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="244"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="731"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1070"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1478"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1628"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1498"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1532"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1630"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="14">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="900"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="934"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1014"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1015"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="1016"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="POY70247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1669" mass="185097" checksum="4955BC8A8C2F0E48" modified="2018-07-18" version="1">MPATPIPRKKGPQNAFTRGLAKMTNFDLTKVFSRPYRNPYPREVLVNVPVPPEAFTTGPKVPLPGFSRTIKDSKGEVIRKEPRGLGTKVVPAPGWTFVSNQVLTSKYNLITFVPRNLLEQFRRIANIFFLSAFRDSYWVWPTRKLTSVRATVLVILQFFPRFTTVSPGLSALPLIVVIFITACKDGYEDLKRHQSDRAINNIKVIALRGTFHNQNVTLPKSRTFGLPVFMRQWFSKRKLVNEAKGEEREAEKGDLPRRKSFWGKRTLRRPGKKALKEDAEKSKARSDEEIAADLALPGGGPNNDKGLADLEAPQIAPGGGTVQSARARSATVGTKGSSKSGGKGGRSRSGTTSGAGYEAPLPDKHARLEGDYYADDAEAAEHFVGPTDTPGKPRVEQQPGSSTRHPPLPHAPHLLGSRYDRPTWVKESWEDLRVGDFVRLHGDESVPADLIVCATSEEENVCYVETKNLDGETNLKSRSAVPELTHLRTSTAIAQDAHFVIRAEPPDVNMFTYNAAVELHDGQVGKDGKPLKCPVNMNTMLLRGTVVRNTEWVIGVVCMTGKDSKIVMNSGNTPSKRSKVERLMNPMVFLNLFLLALMTVMCAIVDHFLEKSQYPQGAYWLYGDNRSGDNPSINGLITWANALIAFQNIVPISLYISIEFTRLVQAAYIWGDDDMKGNHRRTTARSWNLSDDLGQIEYIFSDKTGTLTQNAMIFRQCSIAGKVYLGDEHAQGSESTAEYPADKPVSSSSSAGGDSSTQHSPVDGGAKVKLSDQVLAPFHDARIEADLAARDSPQARGIYNFFMNLALCHTVLTSEEDGMISYKAQSPDEAALVQAAADVGFVFLGRDKDVLRVQTPHDDDVVEFQLLNVLEFNSSRKRMSVVIRKISEGPGQDELILLTKGADNVIFERLKPSNSELKRETDKHLEDFANEGLRTLCLAWKPLDEEVYEDWDRRYHDATTLIEHREEEIERVSDELERGLDLLGATAIEDRLQDGVPEAIADLKRAGIKIWVATGDKLETAIAIAKTCNLLSRDMNLIVVKGGAYGEPKSAYSQLRTALERFFDGDGLADQLEHQPPDAGARPAMPRSSQSGRGSFQALRRTVSGVSGMSDIIGEDNGQRPGGYGLVIDGASLRHAFEEPYTKDLLLELATRCRAVVCCRTSPLQKALIVRLVKDGLGSMCLAIGDGANDVSMIQAADIGVGVAGEEGLQAVNSSDYAMGQFRFLKRLLLVHGSWSYLRNSNMIVNFFYKEIIGVGVLFWFQFYCAYSATTVYEYTYLLFWNVFWTLVPVIFIGIFDRHVGERVLMAIPELYETGRRGKRFGLIRFCIYMLDGVYQSVVIYFFLYYTYNTTTSGQNGYDVGLYEFSTVMAVAAVIAANMYNGFNTYSWNWWVLAGVLIGPVLIILYTAVYSAFKPSLIWTFVWGNNTFLWPSAYWWLGLVFTIILSLAPRYLYRFIKEFYFADDTDILRQIEKSDPHHDWVHDPNMPQPAVEPGHFEPAAAPTPDSASASVPIISRPSGDPGSYQLGRIRTEQSLTHDLSTGRSRLGTGSRYGFDEGVQLDVTRYTSRGSDRSLPARTRSRKGLHLNPFARSPDKKPSRTGTLTSRLVPSRLRLGHSRDIHEHVDEVDALPDTAPVPATTLLPPLAATDGHQPVEGADPQTPGTVGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0J0</accession>
    <name>A0A2S5B0J0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000127">
        <property type="protein sequence ID" value="POY70300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0J0"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="437" mass="51085" checksum="6CD0DA70EFD050BC" modified="2018-07-18" version="1">MPPPSEYRLPPIRAVLVVVAVFAVLSHFSAVHHSESYSASVSSVRDKLGLGSDGMPLGARVRLGQAAAGSMASHGASMWNDDRVAELNSSTRANATFFILARNSDVWDILKSIRGMEDRFNHKHHYPYVFLNDQPFDDDFKRLTSSIASGPCSYGLVPKEHWEEPAWIDETKAAAARQKMAEEKVIYGDSKVYRRMCRYESGFFYRHELLRPYKYYWRLDPNVQYCASREPLRPKPKSRRHGLTLWSGGCFVTRTVCDLDYDPFRYMQDHGKKYGWTISLYEYEATIPTLWQHTKDFIDRHPQYLPEQNLMEWISPDQGKTYNRCHFWSNFEIADLDFFRGEAYSRYFDHLDRAGGFSYERWGDAPIHSIAAALFMKRDQVHWFHDLGYRHEPFQHCPQSAKDRCACDPRSQQNFESHWYSCTPKYKELQPDWKAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0J5</accession>
    <name>A0A2S5B0J5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0J5"/>
    <dbReference type="STRING" id="741276.A0A2S5B0J5"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="6907" checksum="4688215E7F379735" modified="2018-07-18" version="1">MPPHRARCATPAARLLLPRTLSEHPLNSFKGAGANILRGVAGAGVLSMYDKLQELVFGKVYSGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B158</accession>
    <name>A0A2S5B158_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B158"/>
    <dbReference type="STRING" id="741276.A0A2S5B158"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="11"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="286" mass="31637" checksum="52A7F4BF168BD691" modified="2018-07-18" version="1">MEVVDIAQRLIAGSTLVKQGAEGRAYRCDLLPSPLMVQSSSRACEDEASRRDPPASITILLKHRFPKRYRHPSLDSQLTRQRLTSEARALVRCIKAGVSVPALRLVDARQGCLGMEWIDGWTVRELLGGGQEDDQVPSTRDDGQASRVGHDLEAMGIDEDEMLAAVGRQIAKMHLADIIHGDLTTSNLMVRKAGAHPGSPSPDLVLIDFGLSSSSPMPEERAVDLYVLERAFASTHPVLPGTAPHFERVLQGYKEGMQQGRKGEWERVEKRLEEVRMRGRKRSMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1H4</accession>
    <name>A0A2S5B1H4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1H4"/>
    <dbReference type="STRING" id="741276.A0A2S5B1H4"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22950" checksum="BE187523EADE0419" modified="2018-07-18" version="1">MVGKNCVAIACDLRLGNQALTVACNFEKVFNATERTYFGLPGLASDTITVRDKLRQRVNLYAMKEERTIEPETFCHLVSSTLYERRFGPYFVEPVVAGLNSKDEPFIAATDLIGCINFAKDFVVSGTASEKLFGMAESLWEPDLPAEDLFETVSQTLLNAVDRDAYSGWGAVVWLIEKARRLWPGRKNRKDKVTKRWLKARMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1T1</accession>
    <name>A0A2S5B1T1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1T1"/>
    <dbReference type="STRING" id="741276.A0A2S5B1T1"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="104"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="230" mass="24190" checksum="5397798EDFCAD384" modified="2018-07-18" version="1">MVKQNAGGSDQQAHYSETVWGGVRGGLAGLAVGGAGAFAMQRAQVQAFTRLTLPLKAFAVTALGTAGFIISADKAAREYELKKYAIGSGTELERISHEGQRLERQAGIGGPAPGKTVSTREAVIEWAKENRWTAVGLTWIASMVGSGAYIAASPLSFAQKLVQARMVAQGTTVVALIASAGLNLIPNDEGKSDEDIKREEREAGMYAWKKNSPHVQHAQQQAQAAAAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1T9</accession>
    <name>A0A2S5B1T9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1T9"/>
    <dbReference type="OrthoDB" id="2525137at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015658007" evidence="1">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="279" mass="27772" checksum="1B27A2A24B8CB920" modified="2018-07-18" version="1">MPSLKAVLLSVALSALALAPVAQASPLKAGEALARRSSPTFYSNEAAVDKRSESRKELTARVKRAKLAAARKAKRATRMTFAQQVAAQKAAAAAAAAAAAPSSSAGDSSGAYAPGSPFLSTPQALAAASRRCGVSRTCETTTTPPANANAICLSGRCTFRCQSGFAPGGAAGTECVQGSTSCGPNACNAPTNGYATCAGETCVYGCNAGLTLGTNGGAPVCLNLLGDPANCGTEGAVCPGSYNGVGTAACLFGTCGLRCPQGSYQRRTQDGSANYCYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B234</accession>
    <name>A0A2S5B234_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B234"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015485673" description="Proteophosphoglycan ppg4" evidence="2">
        <location>
            <begin position="18"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="79539" checksum="9AAFEFFDA3677EC2" modified="2018-07-18" version="1">MLVSLLKLLLLSLNIRASHKALAPSRVAQSRNGRERQQETGRARGERARRKQVKEEVVNWIVWIAFATAERLADASVGRLLPLYGTAKVVVLLLLLVLRGPGAQQIYDKVLAPLIHPYERPLDLAGFVVNEILDIFIAVLLFLPRKVALRWKGRQTKDDIPAILRGLRQPHQPKLAETLADSIERSQGDSNAVSARFAEPIRVRVQPVPFRPSRPATSTSSLLPRGNGVRVPKSTAPTVSTASRRRDDLPPPPVASTAPFRPVQIIASPYDIHSDSSEEQRPRERRSPGSSSRGGGAHPNAWSSTSIYPSLKEVSTPLPVPRLSSHRSATDDELSDAAGGETAAARPEVGSSRTRSTAPSAAKIPRAGASEGTTPASTPSRRRSSAHVSNSAAADSQRVGPPPTPAPPGAFSFLAPPSATSGSPRSPQVPASVDAAMEDVKTDEADATPPRRRSSRRSAAIPRDSGADRAQKRKRVNEGEGSLAPLELAASVEATLARKRKSVQLAGTSSSMSGDARLPVSEPLVAGTPRQRALGAIAQLSKDMLDDEDEGPGLAPRSKSGNGVLSRSIRGQTTQAVTTRRAARKGALPVRIRDAMGDSQESSPTVSPRKRKAASNTDEPDQPLDDPEPPRPTKRVVTATTRSSATESGKTTASRASGLPVPTASLPPTSRLSDRTVSTSLPKARRVSAQSASTAASEDATVGAGAAAEIAPKAPRRARRILLGRAGPGGAEEEEEIDGVPVVRRRKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B283</accession>
    <name>A0A2S5B283_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rrn7/TAF1B N-terminal cyclin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6071</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B283"/>
    <dbReference type="STRING" id="741276.A0A2S5B283"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="11">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="834" mass="92273" checksum="C62A7D4C96BB5178" modified="2018-07-18" version="1">MARRPRCPVCRSRRWHRDGLSGAIVCEEGHLLAGYVQETTETQEGPSQHTQTTRRIRKNRQRKLKPPANDHFHGDRSQFLVWQAMQLILREQLRVLIDDLGWPVQLEAVARDLWALLVASSAHKSVPSAPRDYHLDEEPATSYSGPRKGARYNRAGRKPYGRRGFKEEDGEATDDDRQDDGDDENEPGGPASEGEAETGSATEATVQSDADSDAESFFSDGNDQDADDERPRPGRSRRASPAIGLGLPSSPGGPSDAPRSSQVNPAQSRFPPQKRRRTVPPPSKSHDVRDRPRLEYTLLVVYLACVTLKLPVMLADIFRLADTYQVLYLDAATHLPAEMQAHLPKEARDLLSPHTTPPLYTHNISLDRIASDDAGTVQGTLARLVSLYREDWKVEFPEANVPLLLARICCGWLALPQDEPLTLWPAAARAYHLTLSLISHLPTSPSFYLPASLHFSHAKSSTAFSTLVGGWPRARAGSQDWRVALPEIKLASLVVMACRLLWNLERESSEVEGASMARSTSLATAIFDDSLPDQSRWLEAVERLAQLEQPGDPSRLWSREVADMAVDDVDAYLAFFERKIVSREKVPTRMETVSRCFPPPLAEDVPAVEQLAPQEYLNRAEALVGALYSSATGGAESTSAVPDELSFILPETCLGQHLPFAPSDLPQPLVRLLTVFASRLTPLPTSLHVGLRGPAPTDATTGIANLLPFVDQVERALLAGANRAASTRDPDATTSKQETVRALKARAESERRERFRRERNRRREVDLLRGVAVVDPEEAEPEHTNEAVGVRLEGPDGREIKLGRPRVRLIKSRDVIDSDEDGNVDMEGGLHIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2M7</accession>
    <name>A0A2S5B2M7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2M7"/>
    <dbReference type="STRING" id="741276.A0A2S5B2M7"/>
    <dbReference type="OrthoDB" id="10650502at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="927" mass="99821" checksum="44E328DCEE67D4F3" modified="2018-07-18" version="1">MQDSLGPAPSPHQDLSLLRNLRDSILAGTHPLFRVPARLYPLPVKTTIASPRPDPDTEQVAANSGPGRGTREQPQGDESGSPTEMMVIDEPRAPRDTSDAPTELEDGEEEEGELIVTETVKVEQPTVQEASSEDLPMNASVTVPTAPVAAAPVEVLILDDDDEEEEREKGDYATQRDQEMGDPEASTSAPSVVPAPAPESSRYTAAPNIDTIDDASLPDYVDSDEDDDDFDPSILVTRTTAASAADQVEELLILDDDDEDEESDAAHVSQTVLSRDQGPEDASQTVVPAARSPSPSGVNPRSTTSPVVGSGADASTKESSLAPAQRHATSLSLRLKLEKERLAAAEARLAAAKEATASRDASPAVVAQEAASSASAPVSVVSVTDAGPQIPSQTRDLEQLPPTPSSDVVIVDTSKAPPAPPRPAKAVSPAPSSGSTVSRQSTATTTSSRPVGNAEKRPSSGSIIAAPAKDDARKRARADPPPPRARQSRGRSRSISPRRDLRGPPPPPRGRPADSNMSRGPPPPSHGGHRRQFSGDDGRDDRRPFGLDRARSPPRHFLDRSGPPPLGRPYSPPPPHMRGGRYSLSPPRRSMSPPPRRPLSPFRRPLSPPRRPMSPPRRPFSPPRFPLSPPRRAMSPPRRPMSPPRRLMSPPPRPLTPPGFRQYGGPPGPGSFDGRSRRSLSPPPSFGPPPGVYRDDLDRGPSRFERYDGLGEFGHPRSPPASFYSDRGPPAMPPIGRDFPPPHPPMPPYTQSRPPPELYSSRPRSPVMPPHPAGFRRPLSPPPPHQQQPAFEVHTNRPLAPYPGSGPVWIDRNERDRQDRDRRFDPNMPPPPLQARGGMMQPSYLPQQSAPMMPRPPPPAPPPGYPPLYGTPPMSAEFERFHRPGDDFARGPPPPPPSRQVGPPHQGSMPPPGRRLPMPPPPPGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B317</accession>
    <name>A0A2S5B317_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Shr3 amino acid permease chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B317"/>
    <dbReference type="STRING" id="741276.A0A2S5B317"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27073" checksum="2B1F8CE09C89F229" modified="2018-07-18" version="1">MGFLTAAATVSAAFLVGTLFTSLLWDATVLYGLTEPINERMIEAVENYYLTWWNGGMAVKMFMHIVMIVLFLSLVAKWARRSETAFYFSGASILALVCAAAMYITITLPSIRIIARDPLSKSAFIIPGDDFFTRMQGWLAARSTGSLGTRARENAAALAQLEPMGWVGRVQHVQVLCAANTINMVLLFLIVVLQVSEWYLDETILKENELEARKQAAAALGTAAAATTAVEPTSPAGKKAVTKEKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B332</accession>
    <name>A0A2S5B332_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B332"/>
    <dbReference type="STRING" id="741276.A0A2S5B332"/>
    <dbReference type="OrthoDB" id="2564267at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1054" mass="112197" checksum="BBEE56B75C60F8E3" modified="2018-07-18" version="1">MSGSTSAELAADANATRARLAAALLGHDLSTDPLQNPFLPIHSSALLQPYQHLLQREADALDDSPGFKQSPALEADSRASQENESPLGDSGIEFRRRPSYNSPASWNLAASRNPTLTDLNLAAGEEERLADEWGLSEAISRAASDTSEPLVGTADLLGRRLSSASDAILLSKRHRGHGAEPDLEEEDMEVIETRSEPGLSRPKSGSFIDEVLGDLETRLKTPRARPAAGARPSSADDEPGYALDGPRVKILERTPTQRRRQRPESRATAHTLSFLEDITGDGSVGDLSDPHDGIASRDSLFRGNVGAVRRASTISSTYSMNGAQPRPSSIADELVSYGSRPASRLSMPLAGGRTTDAEMSDAALSPTEARDSTARPTSSMSVYTSRFDPAVIAAQREELAKDRPKFVDPDAGRPPLVVLLPAPLAGQPAVPVQPVRPDGPEPEVDADSTLLDESDEDLPPGLVEPKRPAGALYGRSLLDVMAERKALLKAQVRAYVPGSDGRRQMFDLHAEPGPSHGLIDQIPSAGLVQLASEYSGDDQPRRQTGPPRVPLAERKAVQSIFGPDTLYQRESAIAKQLDAAERKEREAQAELEALRRDEAEQKKVRKKLRKGAKTARATGVPKSSSRASAMSMATQGGTEVAALDGWMEPLELAAADRHADGYGETDFHPIPRQEPRHSVAPSLSVPGGLNSGMVSSTSEWLLTPEQRDAAARARDNERAEEDADDEEGFRPRPLSALAQLGPRRATPLRRTFSFETDSEHPASGAGTAELAARHLPLPGEPSSIGQGTPSIADTEDDRPIGERYLRAVDGGSTATSEDDQPLGKRYSRLSLPHFAAGPPLVLGDAGDVDASDTSNIREVPSGASEQSHLVAGTSDGRDDDEDEDDAPLGARYSTVLPDTDDVPLALHRLSLAPAPLQHFAPHATIRPLDEDGRTVSGDSDDEPLGLRTAQPAYPSAPFYGGLLSASGPTFPPYSTGAPYLGMPTGPMPYYPPVAVPAPYSHPFPTQAGFAAPAGPQMQLAMAEMQMQAAMGSSQAATMGPAGASIDRWRKSVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3C4</accession>
    <name>A0A2S5B3C4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3C4"/>
    <dbReference type="STRING" id="741276.A0A2S5B3C4"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27210" checksum="C06C3CE1AEC436EC" modified="2018-07-18" version="1">MQASTFASTSSHNASTTPGSRSRPTQADRDSDGNDSDALLEELEAELDDDFDLGGFREKRMMELQAQRVFRPSFDRRRRMQDGDYGRYNEIKVEKDLISRTAKEKRSVVHFFHKDFRRCKIMDGHLEKLAPKHLDTLFLRADVANVPFLVAKLSIKTLPCVIGFVDGITKMKIVGFDELPGGDSFTTSALELGMQECGVLLKEGSNPWATASTREQPDDASQNRKIRRGHLPDEDELDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3D2</accession>
    <name>A0A2S5B3D2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3D2"/>
    <dbReference type="STRING" id="741276.A0A2S5B3D2"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="584"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="624" mass="69296" checksum="CA16447E8CC9BBFC" modified="2018-07-18" version="1">MSFVVTEPITEGVVVLHTSLGDILIELWRRECPKAVRNFVQLCLEGHYDGAPFHRIIPGFIAQTGGSDDCIYDEGSFGIETNQASFAFPSIHRRGRKADSLQRDHPPAPQVQPARTCGDGRGPTDKVQHVANKHTLFGRVTGDSLFNLLKFSEVELEPGTSDKPVYAPVIKSAEVRVDPFEDSADPIRPRITAEERKEQEKAKREMKAERAKERQQGKRKGTKNKSLLSFGEDAEDPEDASLPKTKIKSAHDVLQDSRLSNRVIDDRGLSATLPPDMMLGGRAATAEQERDRDGREDVKGKKRRVEADEPAGQRDEKRSRAEADVESGSHKLEEARKLKGKAPKSEAERRQEEIAKVQAELKSVAFLPMVLRKARKLTLGVASIRKMTGKAGSDDESGKSKKPKRTGPSLLQLEREKYMRGGAMSRGGKGKRKAGAADDDDSVLDALEGFRSKLFEAAKTAPKELEEDEAAAGDRPEKLHGIDLNDDELDEDIGDWMSHSLKFRKDATLDQHQADEYAVVDPLAKNSMTLEEMRGKADNRGQRRYAGEDRGEPRASGSGGRDRDRDRRRDGGRSAGGNGGGYGGDRDRRRDDPYSSRGGREERADRPEVRGDWKRDRMDTSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3H2</accession>
    <name>A0A2S5B3H2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3H2"/>
    <dbReference type="STRING" id="741276.A0A2S5B3H2"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="989" mass="109202" checksum="96D2453DF2A764A8" modified="2018-07-18" version="1">MAQAPTSPHDVLNALNLSLSADPAHLDHARQLLGTWQHAPGFYTYLVDVFTTREGIQHEVRLQAALQFKNGVERYWRRGALHAISPSEKEAIRPRLLQMVTEPNRVLAKTISVSVATVAKYDYGQEWNDLPTALLGAIEAGLAQADTIEGRTLVNRALRFLKASAKALAANRMPKGRANMMRFADILFSPLAEVHAKLLQRAVQDLQSTASTSQDDGVDTFESALLAMRTLRFLIMYGFKDPNLSGEPTNFYRSTLPALSQLLELRLSLLAAGHPCIHSPAFVTFTNHIIACGDLTRSLIGDKLGAFTAMGVAEQVRGIYIQVVEGAASDILANVHDDLRSRYPTRLVVQALLLIKAMLGDWDGSSAVPVSPEFVQQFAEVLITRMLPLRAEDLQKWEEDPEEWMNEEEQDRWEFDLRPCAEYVLKALLSAHREQLGPNMASLLQQVSTPQSMNDLLLKEAVYTAIGRSPSDLEQYIDFTSWLNGTLAPECAGTDSGYRIVRRRIAWLLGNWVGEDLAATSRTQIYALLIHLVGRNPSTDQAIRLTAARSLACCDTWDFDQAAFLPHLPAAIEEVVQLLSEVSEPDSMKRLNQTLGVIIDRVGAHIAPYSQQLALILEQLWHASQENHFQTSILVTLTKLVEALDDQSQALQQQACPIIRASVDPSNPSYVFLQEDGLELWQVLLRRSSNLSEEMLGLLPLLISLLATGTDILPRCLAIFESYLLLNAPVVVPPVVNGLFSSIQDLLEGLKLDAVKVILHALNTVYQTAPPASWAHALDASGCFAFYLTTINRSDVSALIVTKYLSSLARIILASPDTFHQLVAAAASRSGASADAILDTIITQYVDRLDNMSQGRQRKLAALALAYLVPTTSPTMLGRLSDFIALWSSVLAQTEETEQGDAELYHIPDDYQSDVEVDYTETLETQRRQALSSHDPISAQPLKATIGQKLAEAQQLNGGAEVFQQQWLSRVDPLLTEDLFARLDGRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3V3</accession>
    <name>A0A2S5B3V3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3V3"/>
    <dbReference type="STRING" id="741276.A0A2S5B3V3"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="33625" checksum="72636AFBE9A65B0C" modified="2018-07-18" version="1">MPRSNASASGSDDEGFGNVFQEPEDFRPATPPPTVRTYDRRALGGRGPLVGDQQVQVGLVSGHPLWGHVLYPAAIALARFLELHAEVLWHGSEGKGKGKGKAVLELGAGGGLPGLVAALEGAGDVVISDFPDPSLVNNIAKNIELNVASVPSDQVATATAKGFTWGSPPYSLLKALSPTTEDGPSTGPRQFDLILLSDLVFNHSQHLALLNSCLSCLAPPSASSTAAATSASSDSRPDQPEIDLSDPESLQTPAVLCFFSHHRPWLVEADLEILELAQENGWTVRKVWEDKQAGPAFPEDGGDLGIRSTVHGWMFTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3V4</accession>
    <name>A0A2S5B3V4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3V4"/>
    <dbReference type="OrthoDB" id="10673217at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="553" mass="59004" checksum="A3D51371A3410D7A" modified="2018-07-18" version="1">MEYGPADSSGYQQQPRRMIRQPPPPPLASTSSWRSEYQSIGFPLEQLQLDLEAYQVQPIPALTRSPPDPAFPPVSGAIPPAPNRVVNNRRRSSIAVPYLTSSGATLPPADANSLSSLNAGPSVAGVAGPGNRRLSLSAAYTAYREATAKFPPSPTTPGGYGGRTASSTFSSPRSPLHQPQPHAYPNPAAWPTEENPSFDLPWARGERDPAREHGLRTPPPTAPLYSAMAGPPTLSLPAHPQQDASTSIQAGWLDPSFSFGTSRPPPSEKISAPLPFTLDPPAAFVPERTRYSIAGVILDEDDFIDYATSSLDWADANAEKAEPALAGLTSPDVVTTPSTATTMTPNFYGQLLSSPLELSRPASAPPEKRQFRPSLPHNGPTEQDDGVFYQITNRRRSSSVDEGMARAAAASGLPNPVASDSRRGSLVARSSMRGWRHYQQQPGDLEGDGDAFPSFLYQPYDNPHAPGSPTKPRRPTTPRTPSAAPSQHSPLSPRAADKLRNSPTSPRGRRPAHRAGEGLSFVNFSPADAPKILKGVSRSGGSGRSKSPKKKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B418</accession>
    <name>A0A2S5B418_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B418"/>
    <dbReference type="STRING" id="741276.A0A2S5B418"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
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    </feature>
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        <location>
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        <location>
            <begin position="684"/>
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        <location>
            <begin position="705"/>
            <end position="718"/>
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    </feature>
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        <location>
            <begin position="735"/>
            <end position="757"/>
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        <location>
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            <end position="770"/>
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        <location>
            <begin position="837"/>
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        <location>
            <begin position="906"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1230" mass="129387" checksum="473D5DCA578E2307" modified="2018-07-18" version="1">MAGLQDYAENDDEDWDLEQDLQVPEAGLVAGAPFTLDLADTNASPEQFNIDAAARELDAEWSADLDSVDRDDGKTSSLDSTRTDSTTDTLNGMMDSLTLTEGDDATAVLRDSVGSSASTETALSPSERDLAGPETPRAEQRTTTLRASSSLSILLASASRSPSGRGKVHHLGSTKAKQVDDDDWDNDLEGLGSLQLRGAASGTNASDAPIRPGQSRVVCKKSSFASHISLEDEDHGVVEGILGESHKSPAPTELPRRRISIASFSDADEDLSRLEDDFDLPGEVSHLSLAPKLALSSRASISSLSSDLSSSFSPPAASSAAPLTDQRRTAGPPSGPSAPNAHAALSPGRPAEVIDDGLSSSAAEEDDADFFEDLVLPSYFLGSTPEEPSPKTPFTPPTSEGELDSDHASSAKKVSLTDKVDLQAILREKLELRGGRGLLFGAGPGSAAGPGTPEERERLERHREQPDEVETAQMADELGRPGPLGSAQPISPTPAAALAAGGRTEASWTAAEMRERMRTISGARAREAQLAQEARAAQRANSGRRLASALRRTASEGEVPAPPSRRRDPPAAASLAADAVVPGHLGLVGFDRGQATIVPQPSRGATTPNPHRQIERPASAASSRSTESNTQKRRPPPAPSAASRGRQHPRTASLRATASALSLSSASVDRARPLGHLDVGPAPSSTSSRSSLLKSRRSQQQLGSTTLVPSTSQLSSASPAAVAAEGSSPLHPRRSLQGLSALASPPSAPRRPASGSLTTRPSSRQLSMRSPSPARPGLPSYAAPTAASNSRVRERVQSLPSNAPPPSPIPVSTLSGFVRPKPTPVRGPAPRERYLQVAARPASRSSSPVKPSLAPSPRLPTALATNAVRSRAVPTHYSILRPVPVPTRVGRQYGDGTELDAFDDLPVSKEREKERTVLPASRKSSGASSATAKNGSWGRRDGAKASAAVKRVGVATGPELDTDKVAGTLRAGDSERKKSKRRREPHLIRHLGNANAVKVQGDMTYNPKLQRWEGNEAVLRDFDKALATSTRPALISPLSSTLMSPSRSLFSAATSKNLSVTHAGRSDVVIAGAGSTVSRATAKVVGDMVFDPATCSWHSLAGPDAEDALELDWGGGTSGGENADDEAFGGGLSELDGWELGERERMLQTRASFVLEEGSEGDEEGGSGARDATDADGRKKSTKRQIWREGKAAEERCRREMHGWTVVGAVDAIATQHDWLWELRSLLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B425</accession>
    <name>A0A2S5B425_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2527406at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="49935" checksum="E060591511F77869" modified="2018-07-18" version="1">MIMSTAEPLPPTRLCSPSPRRRLSPSLDTLPHELLAQIFTPAVVGPRPANAPRPPADDQNPEAPLHLSPVSIPICRILLPFARHNAYHRIRLSGGLKGLERFGATVRSPDEAEGSGTSAWIGEMVREVQVQPSRHQRRRVVAAEDYDIDMRAVTAAFDALTDVEQLDLTLSGAEWARLVSPSVDNDVLASSASNRPGGVALTVRLDRDDDIPVGLVTLARLEACGGIRELRVLGRLPHKVCIDGFGGAVTPPLANADGPTWRGLESLELTCEPHTTGLTRFMASLAELKRLRWTTPGTTDANVAMFAIPPNVCSTVEELEWSTYGYLSRPLDVAFSTLPRLRSLSIASTAATLCPTFFASLHAHNAALERLELHGPRAEGGDAAATCALVSEWLEALVYEAEYGNGAATKLRELVLDVTLPRLTADTALASEARRLRECCARLGISLGGSVLDAVSKRASPDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B473</accession>
    <name>A0A2S5B473_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIIE beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B473"/>
    <dbReference type="STRING" id="741276.A0A2S5B473"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054600">
        <property type="entry name" value="TFA2_E-tether"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22254">
        <property type="entry name" value="TFA2_E-tether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="8">
        <location>
            <begin position="47"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="291" mass="32241" checksum="73B8175CE34C77EC" modified="2018-07-18" version="1">MSKSRLTLWLSRVRWRRSRRCSAKFSRPLLWPLLPDLSLSLTRTQGAMDSLNSAAVGRHWQTQLALLVAFLKQHNAPIRLEDLAIRSGVDHLLASPELQQGLRQHDRVRFDERTQLVSYKPDFVLNSKSDLIILLRRNSPQGGLPVKKLRESWAGVTNAIEELEREGRVLVTRTGKNPHSGGGGGGGGGAGDGQMKMVFLDDIGRDRDPLDQEFKDLWHSLKTPIGDELAQELQAAGLTASSAAPPPPTTNKKKAKGRKGPGSSNRRFKITNTHLKDQGIDLSKDYVPQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4N3</accession>
    <name>A0A2S5B4N3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4N3"/>
    <dbReference type="STRING" id="741276.A0A2S5B4N3"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="214" mass="24476" checksum="73C2D60BFE6BDBDE" modified="2018-07-18" version="1" fragment="single">RQDSPIQTPQGWGQRHSRVPAKERGPADVLLYALSLGSGNLRQAVVLPEGEDLNEWLAVNTVDFFNQLNMLYGCITEFCTPQECPVMSAGPRFEYHWQDGVRFRKPTKMSAPEYVDHLMNWVQGMLDDEAIFPSQLGAPFPKDFVTTVKSINRRLFRVYAHLYNHHFAQLCALSIEAHLNTSFHHFVLFLDEFKLVDKKELAPLDELVSSVLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4S8</accession>
    <name>A0A2S5B4S8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4S8"/>
    <dbReference type="STRING" id="741276.A0A2S5B4S8"/>
    <dbReference type="OrthoDB" id="76305at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11692" checksum="C902B24748E9A98E" modified="2018-07-18" version="1">MSRTAKVVFGASCLLAGVSIWGVHMIQVRERETMFAGVIRDTERLEAKRLQRERQLEFEDQARKRAYLESLQGVSNPQAPAPPVLGQVPTSADGMDFGCKTCDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4V2</accession>
    <name>A0A2S5B4V2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4V2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4V2"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="611" mass="65526" checksum="BF0E91D485F7CD01" modified="2018-07-18" version="1">MSEVASTSASAATATTDVASRKRKAVDEPDGHASGSNYDTNDSTVSKVNGDGAEGTTDTTTAAETDPPASKRGRGRGRGRGAAGSRGVGTATARGRGRGRGRGRAKARSRRRDSDEDEEEEESEDSSAEEDASDEEFAIQAAPTRTASGRRTRPTTKAVDMHRSSGGSGSSKRPSPAPTTTPTPVAWEDQYEAKMKPAGPDELAGSSTVSKQQVEQDLAFPAFARVGELVWVRVPLGPPPAGALANAQLSRWPGIIRGRTVVENAGATEESYQVELLGMSDLDTLSGVRAENVAAWLSYIPSNTVYLDSTPLEDDGLVVGDAKKRWATIQSEGWIGVANAFRKAQRIAKAYAAIQIRPIPQLRVGSHLEATPDGPTDDLDKLERKDAQSRYLSYSHILCGPEILHAGDFVRLRRGAQIVTNTRTFAETGLEIPTSLVMRVSTFYRGENRSPLMARGLLFELVVSKPDDRTYDRSLYALPPDIRVSLPPPLPGHKWKLVREPGVSGNAGAVRDFETNVIFDAAVAGRLYPISPDWPINRDPMQLGIYLAEALRVKKATPGMGEEGLRALAVMLGGMAGTDRTVSFKASTYLAGDRKAQLVAAEEQALKSRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4W2</accession>
    <name>A0A2S5B4W2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4W2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4W2"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="258" mass="27598" checksum="9410AAD20845DCBD" modified="2018-07-18" version="1">MFSRALASTSRLAASPASTCSACSTATAAAARAARPQPSRRLFSQSATARGNDAGLELPTTLPRHAQPQAYTPKPLPTQGPPSEPSALALLKSQPSHYITALFMGRRYLLSPGDVLTVPYLKNAPVGSRLALTRILEVGSRDYTLRAGSATSSAPTSVSSVSSAALASYSAPIVARPPASRSVAIEGTPKDWQRHPDSLPYLGDDLVRAEVTVLEHTKGAMFEVEKFKRRKGYRRTLRSKLGFTKLRVGEIELGPKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5I9</accession>
    <name>A0A2S5B5I9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5I9"/>
    <dbReference type="OrthoDB" id="2530412at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="259" mass="27812" checksum="F114C2ECF880B9C0" modified="2018-07-18" version="1">MSRLRTPPDSTATSSETSQSSKKHQLRHRSPRGQRGRPRAGPTSTTTTTTAQATHQDGTTTRHRQRDRSSQVAPQPGQWDWAWKHRRELAGAAIAIVVVLVVSAIRISLHSADYSSGAVYSPPSRASRPPSNVRTKPSPSSLTSIIPSPSAGTSHMRGDDARRDKVDSDEADEKVLHEALDSAVRHALEDAWQLPPHAPVSAGAGPAANAQEPANGGGDSAAPRQRTLAELYAELEDLGISPHELNEVLDETMRSSGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5Q9</accession>
    <name>A0A2S5B5Q9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5Q9"/>
    <dbReference type="STRING" id="741276.A0A2S5B5Q9"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="556" mass="59956" checksum="CB30C582B85E3257" modified="2018-07-18" version="1">MSTKVRVGSVDLLNDGQMKEIPFPNEDSENKVLLSKIKGQYYATSSKCTHYGAPLAKGVLTSEGRLVCPWHGACFNVCSNGDIEDAPGIDSLQSFKVETDGTSVYIHADADSVTQTRQPAAPTVDSSSDSSHVDVLIVGGGPGAAFAIEALRDEKFAGSIKVVTREPHYPIDRTKISKALVSDPEKLALRKPEFYKKQKVDFVLGTDATKLKFADATVELSNGSSVMYDNLILATGAFPMKLPLDGIDLGNMFTVRGVKDAEAINAAVGEAEKDEDKKNVVVVGSSFIGMEVALALAAKAKVSVVGMDKVPFEKILGEPIGKGIQKFHESKGTKFYLPAELSHFEPKKDDSKVVGSVHLKDGTTIPADVVILGTGVKPSTELLKEAGLDLEKNGTVKTNEFLEIEQLKGKGKGRVFALGDIATHETPKGVNYVQHWCARSLKNVAANHGRNIAHTIATNKPQPFDKIAVFWSAQGQQLRYCGTTQASSYDDLHIDGNPDELKFVAYYFKGEEVVAASSMQRDPIVARVSELLKLEKMLTKSEIKAGKSPMDVPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5W7</accession>
    <name>A0A2S5B5W7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum-based factor for assembly of V-ATPase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5W7"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31788" checksum="44CFBCEC836921C8" modified="2018-07-18" version="1">MVLLQLSDPLHARLDLLLKHLPVELRQRVASHLDQVDDHDPPSPATSAAAARKAAIPHEVLVEISQWARARAGNEALEDSDNYRLASLLRLTDVHAPPLPERVKRKTEPMPSSAHTLQSPELLAILAEIQLDQDRRSYSSMTSLSPAGRPSLIPLNDPHTPFGGSTTKSVAEEWTEIKRELGAVVNVTASMLAVATAVWWVGGGRSYAARLGLALTGAIAIAAVEGFLYYRFFTALAAKQARDARQGGVAAELQKARLGSRGGFSTRRGLAGSSTIEDKNGSTTAVTGRLEKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5Y5</accession>
    <name>A0A2S5B5Y5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BMF94_4779</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="PJQD01000056">
        <property type="protein sequence ID" value="POY72203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5Y5"/>
    <dbReference type="STRING" id="741276.A0A2S5B5Y5"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="53"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="503"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="58"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="447"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="POY72203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="639" mass="70103" checksum="DEB70908C5962F08" modified="2018-07-18" version="1">MLSLARRSAHTAPLRTFATSAARQRVIATNPVKAKEVPTTISGKYPLIEHEYDALVVGAGGAGLRAAFGLAESGLKTACITKLFPTRSHTVAAQGGINAALGNMTEDDWRWHAYDTVKGSDWLGDQDAIHYMCKEAPNTVLELEHYGLPFSRTKEGKIYQRAFGGQSLKYGKGGQAYRCAAAADRTGHAMLHTLYGQSLRHNTEYFLEFFATDLIMEDGECVGVMAYNQEDGTMHRFRAHKTVLATGGSGRAYFSCTSAHTCSGDGAGMVARAGLPLQDMEFVQFHPTGIYGAGCLITEGSRGEGGYLLNSEGERFMERYAPTAKDLASRDVVSRSMTVEIREGRGVGPDKDHIYLQLSHLPPDVLHERLPGISETAAIFAGVDVTKEPIPVLPTVHYNMGGIPTKFTGEVLTVDENGKDKIVPGLYAAGEAACVSVHGANRLGANSLLDIVVFGRACAKHIAANLEPGKPHKKISDDAGMESIRALDQIRTANGPKHTSEIRLDMQKAMQNDAAVFRTQESLENGVNELSRVRSTWKDLGLKDRSMIWNSDLVEALELRNLLTCADQTIVSAEARKESRGAHAREDFQERDDENWMKHTLSFQRDITDDKTRLAYREVMSNTLDENEMKSIPPFKRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B689</accession>
    <name>A0A2S5B689_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B689"/>
    <dbReference type="STRING" id="741276.A0A2S5B689"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="260" mass="29476" checksum="59F3777AA547DDF4" modified="2018-07-18" version="1">MDSRQTFILAIGGATGSGKTTLAKHLGRIIPSLLVFQDDFAPAEDQVPIDPRYGWQDWDAKDGAIDWAKQRRVFDTIRETGVVPEEHSSHDHLNEQVPVEIQDETEQRWKDKFARLSERCGEAYPKVVVTEGFLILVDPATTRHFDLQFFIRADYDTLKDRRIKRQGYHTAEGGFWKDPEGYWDKCVWPAYLSAHAPLFVDGNVEQGDLTPGSPVELLQTPELSMDDMVNRTCAQLYEAIEQSRTGAAEEDDRPNGHSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6N8</accession>
    <name>A0A2S5B6N8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Breast cancer 2 susceptibility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6N8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6N8"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Breast cancer type 2 susceptibility protein helical" evidence="3">
        <location>
            <begin position="755"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB1" evidence="2">
        <location>
            <begin position="811"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1179" mass="127741" checksum="3A506380DC7EE77C" modified="2018-07-18" version="1">MDDPKGAQPMSSPLSSLSPSPPPPREQGDEPARKRPRLAGTRSPSPADFVPARLSAANGVQTSRSEVGDVRREADQVDMTASLARLAPEEQDSDATPESFGYAGAADAQQVGATTVRPGERDDSGVGWLPSENDKPDLQEEEIAEAGVEDARDEEEEIEFDGDDIWLGFDDADVGFDQPTTFPSSALVPASVVPHMPSTVEEQSMPLTSGPAESLGASEPRLKEFGFANFDPAGGFVFATRKPFAISEQSMQRARALLDAADEPDDGPEEAVASSRPDANEYAETSTRLALPTPARPTSAQDLVRTSTPAIDLAPAPASSPVRPTNALGVSLGDFSSLGGFQNAAGRNLKLPSEGAMKRARDKLEAKSPSPTKGSSAILRPALPRAGSRGSPSKDVFAIRAAATGAPTPRVFDLKPIAMTDRAPPVTLSPIRSKGTSGDTSASPPRRPPHLAAGSPLRRQLPLDALELQKRQQASLENTEAGPADVGYSASPDTGTWPTALPQQSTATAPGRQPARLPQSEERREAAQPASASRVSGFRPPLRPAAGNAALHTSTPARITRAPSSTPFKIPGAASANPLHPQNRRLSFGLTPQAKPFHLSNARLSTPSSTGRTVPKAFVTPFKGGKRPEGLTPVGLKSIGAATALRAAKTVARDPLSASGRKRDLPSRVADLARREKAKVFDLEAPAGSRHDLTFGMCPQTHYYEHLEEIGLPKEILDMDSKLGARFLFPDGRGVDAAVAHLRSVVEERMPEERDLVTLAWVKNHWALILWKLASYVRSRPDLLHEYWSFERVADQLRYRYEREINRAERSAVKRIQEHDSPASLPMVLCVSQIRWEEPADAAEGPSDGHPPLVIAGLELTDGWYRIRANVDGALRSACERGKLVVGTKLAVSGARLDTNGHEGTDVLHALNRSQLVISGNSTSLAPWYARLGFCQEPFIGGLGSLSANGGIVPLIDVTVERVFPCGYIDLRKGRGTETWGEEEELTRAEEWKIGRRRIEDKLAEESQKESTEEDVLVELLQEAAEGLDLPGRATPRASSPAEEPDEILDRLESATNKRAIIRQLDAHQVRAILLLAQENAQASRFHAVEQLQKELADRYPPRDVRGFRVLRVVDAREGRKGTSRSAQLTVWDAQSFEGDFFRQGQRYLVSNLVPKGSWRTSDREISLTTRRDTRWKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B750</accession>
    <name>A0A2S5B750_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B750"/>
    <dbReference type="SMR" id="A0A2S5B750"/>
    <dbReference type="STRING" id="741276.A0A2S5B750"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="515" mass="54903" checksum="A4C1C198BAB7A1C3" modified="2018-07-18" version="1">MRPPVASRGLARPQRLARAAASPANAAATPSSRSPASCATGRRHASSSSRLSAWTSALPAASGSRTAPIPTAAGQSVRVADPLKLLSSELSFLRQNITSLLGSKHPALDTIAKYYFRAEGKHVRPMIVLLMSQATNGLSPRWTEVQQREMDREQQRREGKGMGVDEPLEQEEVLMDENPSMLERAKDLLRNPMAAFSSSPSSSPSTDASTFASSSANLLPTQRRLAEITELIHVASLLHDDVIDLAATRRSAPSAPSLFGNKLSILAGDFLLARASLALSRLGSNEVVELVASVLANLVEGEVMQMKGNVPSAAANGAGSAAGKDSARSTIVSASSLSGRGPTPEIFEHYMRKTYLKTASLIAKSARATTILGGAGSRQGWVEGEAVKDIAYEYGRNLGIAFQLIDDMLDFTASAAELGKPGGGADLKLGLATAPALYAWDEFPELGELIERKFDREGDVERAKHLILRSSGAERTFALAEEHSNAAIEALRRLPESDARDALEKIARDVLTRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B781</accession>
    <name>A0A2S5B781_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide exchange factor Fes1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B781"/>
    <dbReference type="STRING" id="741276.A0A2S5B781"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="4">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="337" mass="36807" checksum="F661DB0D2150455D" modified="2018-07-18" version="1">MPRAQDPTQSLLRWGIENAAPGSLAATAQQIKEGKRPDLNTDILKAMMGQSDAEKMRECLMVISGQWIDRDGNGEVKNNADITTADKYRAWEDLEMLVEDLDNANDLANMDMWRPIVSFLTDADDEVVKHACWVCGTAVQNNPKSQQAFLAQDPLPTVQSIVTSADASHETRAKAMYCLSSTLKHSEPAVQRFSELDGWKTLTQTLQDPSLKLRAKTAFLLSQLATQSSSPSALLSQLRSASTLSTLIDSLSPSTAVPTGPSGSQDAVDPDLRDKGLRFIANVVERTPAGSDLEGLNAEEKDKIRQVISEAEATSDWTPEDVGMAADEWDAFKRQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7B2</accession>
    <name>A0A2S5B7B2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7B2"/>
    <dbReference type="OrthoDB" id="2529219at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="381" mass="40463" checksum="C2C9A6B29A23798B" modified="2018-07-18" version="1">MDSPDTSLYQPVSLSDTLTQASKRSYRSAGAALTASTSTARLAGGPRSSILPTPQAHRIRSDVARREAAAMCESLGFSGAYSGDEVDATPRPSGGRSLNSAGAMSMARTAREDSPIGVVSLKSNLEDKDNEIAALRRELAAALRDKKDLANQVSRHAKQPQAGPGKGLDVKEMEELERAFAEQEKLLGGYQREVEKQAEEIDRLKSRSRRMAECLERIYGPSYEDELGLVDRPKTSATSPAVRQKLVARASLATGFGSLSRATTVPTSLAACAEVPESPKAADPSSPIAGPAASESADALDTKSPSAGQSCAPSIPTAALAQHLDSVQALLRSMEARLISRDVELAAIEQRAKHERTQAREKQAELEALVAESRKGAEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7B8</accession>
    <name>A0A2S5B7B8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_4449</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7B8"/>
    <dbReference type="STRING" id="741276.A0A2S5B7B8"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="83"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY72621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="401" mass="43637" checksum="AFCB0BC101145A3F" modified="2018-07-18" version="1">MSAAPRTLLTTLRSAVRSRAPAQSPRPWTASTSVQTRSLASAVEAQRPNKGLTREAVQQIYDSPLMELIYRAASVHRLNHPPDQVQLCTLLNIKTGGCSEDCKYCAQSSRYADQVGLKAEKLTDVETVLAEARKAKANGSTRFCMGAAWRDMNGRKRGFERILKMVEGVRAMDMEVCTTLGMLSPEQAQQLKQAGLTAYNHNLDTSREFYPSVITTRKYDERLETIEAVRAAGLSVCSGGIVGLGEKDGDRVGLIWEMSQLPEPPESFPVNALVAIKGTPLEGNQQVTIQELLRTIATARIVLPTSIIRFAAGRIEYSETEQAMAFMAGANAIFTGERMLTTPTSGWDEDHAMLGRWGLKGMGSFESTTVRMKENQNALEATEARKNAGEASAAAGADISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7K9</accession>
    <name>A0A2S5B7K9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7K9"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="121"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="724" mass="81361" checksum="FB465EA552379092" modified="2018-07-18" version="1">MGARAEPPLMLHDINLMRDIPLFQELQPAAEQPQDSDDEPDNSDEDSDDADEEMNDLDEESEMRDSPLSEDLQSSAEQSQDSDEELDDSGEELNDSDEEADSDAEQAGDTCRRAAPAGPQQKGLTDLPLELVAEICSYLPVAAIFRMARVSKPYRRLLMSRANQNIWRTARRNAGWQDLQSGEIGELEYALYIARVCTICGTSDVTENRVTRWADLLCALCEECEDEHRMSYVSSKPTRSSWAGVQLEPLENIHELDVALADCEYLESRSDEWDNDEFVDARAASLSHCRLELMKLGYQVEEVLTAQLTAALPASFPLERYQEWWCSCAGQFSSAAFLYEEEEDVALSREPWIDLNVPEDAALATRAFNAMHAGCHYLPKKLWNYWSHDFDMDEDDYHGPKDYYYRQTADDQGASTLVGLSARCTDHLCTLSLRFRLAEWLDLGKVYCAVAERFKERRVPESWHARLREVRARVVELVREDVKWSASGTPNALDRVWKRVADHPTLVYAPPDDLKNALSLIMSDRLLEFIGYKLHHAKLVVFMRIAVTLRADEPTALPTAINSLLDSFDTNDSTPRGSGSLETHFAGHEQEIDEIMDRATALLRCGFCSRKLSFEQIAEHVTDEHGAGPAAPFALVPEKGFRDAVRSLLYSLQMPITTALADIRTIEVDVDELMPSGLTLTSYGVPFEEALAGKSNCELPRARRLVDGSATDRQILALRPVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7X9</accession>
    <name>A0A2S5B7X9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7X9"/>
    <dbReference type="STRING" id="741276.A0A2S5B7X9"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="621" mass="68330" checksum="9F857D36E29CA663" modified="2018-07-18" version="1">MADAETATTPASTERPARQDGQVAERFDRIRYEDLSDEASWDSIGKGSFGSVWRGEYLGLEVAIKEVLPSTEYDVEKYMAREITLMQQARHPNIVQYLGLCLAPPASAAGEDSPTIDESTPRRSRILIVSEYLPRGNLRQYILDRTLPFPWRLRISFATDIARALAYLHARNTMHRDLKGENLLVSDNERLKACDFGLARVAQALGAVKEDGRKPSDMYTYCGTDGYMSPEILLGLPFDLRTDIYSLGVLFIEIATRKLASQSVFARRPPDYSLSQVEVWSSVSPHCPRAFVELALECCDDDPERRPDCKSILRGLRGIEQEVKEMEARGLGDEDAHTRGAGTCNVGSISFAGTLKRGSLAPSKRPGAPRLPSFEGQLDLRKGSVFAPVIPGLEPAASTSILDLERSLGHIRSRSGSETDEEEGEALLALASAEVPIGHTNSSDEAYSTSVVRPSQIRAPYGRLGSTSGSQLPTLPTSWIMDSSRFADADEEADSKTVIVATTADDKDAPVSAFTTRPDTVSLAGAIADGNELDDEQDVFHSAFQEPPPAVEAAPEWPHRFSLIKSVMSRRTRTAALPRIFAAARDSVCTRKPFSVAIGRNERQMWPMREDLWPHEAVPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Q5</accession>
    <name>A0A2S5B8Q5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase complex subunit H-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Q5"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Q5"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="12882" checksum="05A5EFEB097CA28D" modified="2018-07-18" version="1">MFARRALQAARPLARSFSAQQALRKDFIQELYVKELRAYKPKPVAASAGATKSYSTPTAPKAPVVPDANQLAQELEAYDAAVPIDASASPAAAAESVEEADALGADDYLKLCEQPVHSAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B940</accession>
    <name>A0A2S5B940_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L35Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B940"/>
    <dbReference type="STRING" id="741276.A0A2S5B940"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7626" checksum="A3E24F09713864A5" modified="2018-07-18" version="1">MHQGPRQVHEGRIAYVYTAQKEVGGSKVRIIWGKVTRPHGKSGMVRAQFRRNLPPKAFGQSVRISKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9B3</accession>
    <name>A0A2S5B9B3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9B3"/>
    <dbReference type="STRING" id="741276.A0A2S5B9B3"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="861" mass="93360" checksum="477012DFF15108CB" modified="2018-07-18" version="1">MSSDSVPPRPPPRHPSAASQTSRRPSSVRSGAELDSALANSSDTAQEARADNESTVYDDDAKLAEALAQLEAEQAGTARRTESAARLSATQRVVPDTSSSIPPPRHPASAARAHVVTPPRSPPLDEPLEPPPIRTAAAAAGRGSDSPTLDRQLQDLQDIEIARLLERVGHRLTDVRIAEATDARFQVEYPTKDAFRRPPSPGKERGSVDWSAYSVVYLACLATDYIPASLVDSGPLPRQDFSLRELRSELERTYVLCPPPVWQRIVLTEIAALWQWDAPSKTGGCLAGYLFLWYFDLFFLAPCIALTALLVKVRFFPPSKAELVQTAQDRQARSRDAKALSKQLRSSSVFGYAGQGVKGLWTNWRERVKDLGPVGAVASALGPDEDEDDGEGSDSDDLERADPSARSAQIPAATPAPVQPNSAIGQLVASTNAVSASAAAPATVEVLASTSKPPPEIEDPARAPGGKEGDGDVSLYRLMRSLMAAYGPNVVLWLGEINDAAERIKKYVHLPPSLTRILPGRVTHAHLRLASLIDHPEHPAVRIIALRLAVASIALCFTPISLVYKAAWLYLGLDFFVMWKVRAMYPEWRGATMPHRWLLLGAPNDVQYALYALRQRQLEGKPIHGARTLKRRARAANSSASGDLADGNSDLASASTSATAPAGKLDKTKARARAVSNAVSTVLDEAERYRSRKSSDFDATDRASAVGIPLGKPDASYFALYSSKPGSLCLHQDRLCFVPARHLTTVSRITNLFGSGVPRRAKHGYSDDEDEADDADTATIGSTSSKRTIRSTLSDVLAEGGEIAVLYEEIEGVTKQTKMKAFEALVVKTKDGRTFTFRNVSRRDEAFTKLLSFTAAKWKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9C9</accession>
    <name>A0A2S5B9C9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B9C9"/>
    <dbReference type="OrthoDB" id="2537092at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1837"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="875"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1420"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1517"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1660"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="904"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="947"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="978"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1535"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="2163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2196" mass="233317" checksum="102E62B2E01544FB" modified="2018-07-18" version="1">MPRRSARSKTNPSAEPIAAAATPAPLVAHPASAGPSSTRDLTAPASPVRPGGEAAPSFEAQSITTTESSPKKTVSFDEPLPTSSGGAVTAAASQSGSSQATASPRRSRRNSATTTANISSTEGDNRASAKALGKRRAVSPVPSASSSVAVPTPAPATSGPNPAHASKRRKVSAAPGTTLSEPAKSPARASPRKPKTRSSANPSPAKSASAATPSASTASSMPRRGTRAGRAAAAKARAMEDEEDSMRYDDDGILGASHQEDVDMDDAGDFVPVPSRKGRRSSTAAGSSKQKKGKEAPQVIEVADPEPAASGSGPAGPSSSVASETMATEKGSQAGGGQAEEARAGEPAANQEDDDEDEEEDDGDDDDDDDDESASDDYHDDDDEFIEEYETSLGLHGEERDDYGTEGEEVMHAAPQTFSADGDPLSGGAEHDGDMDESEAAFLSALTGAMRGNAGGAGSSEGAEAGAGDDLPSGLGGLSGMSAFRALHGMMSGNSARLKGLLEALRKKDGDGQAKLLALQDLAELLSISTEDTLGGYFQLEAFAKELVAIVRGDSNGMSVSGNGAGGGDSGMTVEEALAFGLDPSEVGAGGGGDTEENDVQMMLLACRCLANLMEALPGSAHSVVYAGAVPVLCDKLKDIQYIDLAEQTLSTLEKISEEVPSSIVREGGLMALLSYIDFFSFHVQRTAITAAANCCRSLSIESFDRVVEVIPIFKNILGYPDQRVVEQACLAIVRIVDSYRYYPDKLEQLLSKDLIIAIKAIINPDSTTVSASTYTQCLKMLTTAVKASPAVAINLVELDIAHTLYHLLTGVAPPEWKAEEGQQVLDSETAAEDNMLVMQNLVQRPNEVAEVLNLVTELLPPLPKDGVFDSRAFSGKARSSSKADSKKLETVTASPVKREEATPDLASSSSTPATTTPATGTTTSSTTSVPGADIKMEGLEDNKPDVSAAAAPTASVANLRAPPLGRVSSSSSKSRGRPRDPNKDAMNAKRLELVAPDAPAARKLVVKRYIALLLPTLIDVYAASVSASVRNKAVTGMLKMVNYCEEGALADILRSVPFAAFISAILSTRENQAPLVTSALQLVELLLVKMRDAYQYTFRREGVMYEIERLAARPLVAPAKSKRSSPSRTPRGDADTNSSAGPSGISRALLGQGAASVKKLSPSDLQAQDAVTLRARHLSETYGAPDSEPSTRAQGVLERIKALVQHVDSVAHAEVGDGGAKAVAKVEHEAREALEEIAHLFADEKNPLSSFEMLESGLIDGVLKFATETGSGPLSTRQRQELLAKAFMPQLEGGNATPAFVTFVKRLQESLSRMEEFEVVVAAQGADVDSRRSGTSMLGRQLRLRLIAEDGDIPRSCTNIVVSIHAIATFESFNQYLRPRILAAQAQAERLSSGLPSGSGGGTLSSLLAAFAAAAGAELEEDDEADETILSSSPPPRRAELSNPDAGASAPGESRRASSIGRSAKGAAPKRRRSSRLSGKGVESADKAGADEAAEDAETATMDAKYAADEEACAGEDTLGGQGSIFPRPLDAPEPPKDDKPVHLEVNEEGTDGAKLVAKTPDGTRVATPQPSAGASDEATRPSPAPTPKPRASYAAAVKAEPTDFHLEFRLAGRDVTLDTTIFGAVHRHESEQPNPSLGSMWYNVYDVKFRKVAGAARSDEDDANALAERSRREGSIADNMPASIPADSQQGKILQLLHVLRGVVADYAEEDADPATTVAFASSAFVNRKLTAKLNRQLEEPMIVASACLPDWSVDLAQTFPFLFPFDTRYTFLQSTSFGYARLLQKWVGQARPDTNRRNEDLGYLGRLPRQKVRISRDRILESAYKVFELYGSSRASLEVEFFNEVGSGLGPTLEFYALVSKEFARKSLGLWRAGDHTDESDFVHTKAGLFPRPVEDFASEDGKKVLRVFRVLGQFVAKAMMDSRIIDINFSRPFMRLVLEQEMPMTMASIRAVDPDLAQSLQHLQKFLDAKAALEPDSIDHLDALANIRIDDGQVEDLGLDFTLPGTDIELKPDGKNVDVSIHNLEEYVEAVLEWTLRRGVSSQIDEFKKGFSSVFSVRDLQTFTPVELVMMTASVDEDWSLETLTNAAKADHGFTMDSRPVRDFLSIMSEFTPDERREFLSFITGSPRLPIGGFAALSPPLTIVRKGGGDKELLSCMTCVNYVKLPDYSSREIVRDRLRLAVREGAGGFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9F8</accession>
    <name>A0A2S5B9F8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylethanolamine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9F8"/>
    <dbReference type="STRING" id="741276.A0A2S5B9F8"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF140">
        <property type="entry name" value="PEBP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015571718" description="Phosphatidylethanolamine-binding protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="34211" checksum="935BBB2CA7B30C19" modified="2018-07-18" version="1">MLFTAASFATVALLSSSAVSAQSIPAAASAVQLATVSAEYANSGLNNTGAQTTRRRVFGLVDASTANIQPCATRSSRIRGSGADVLLLPAHSNRGFGLPLDAKALLNVILPSGELVQDGQAYSVDQVSAMPTISVTPSNATAGWFNSSAAYTLTLADASSLGDPDAEGNYRHYLANGLTGSAGNSNNLTFAPEGGNTVTYFAAPGPISGTGPHRYAWLMFVQPENFQAPQNLSTQGVAPSHWYVESYAQSTGLELVAASFFTVEVGQPTGSVASTMPVSTVSIASTGSASSAKSTGASKSGSSSGAAASPSGSAAPSSGASKSVVASIGTGLLGLFGLVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9G3</accession>
    <name>A0A2S5B9G3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9G3"/>
    <dbReference type="STRING" id="741276.A0A2S5B9G3"/>
    <dbReference type="OrthoDB" id="2532770at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="11">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="125" mass="13821" checksum="7239E92CCA7D3679" modified="2018-07-18" version="1">MRLASHSLSLHNSHPLNSSQLNMSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENIIRDSVTYTEHAKRKTVTSLDVVYALKRAGKTLYGFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9W7</accession>
    <name>A0A2S5B9W7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9W7"/>
    <dbReference type="STRING" id="741276.A0A2S5B9W7"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="307" mass="33761" checksum="8E553A1C1D4F0B1B" modified="2018-07-18" version="1">MRAHKTPYRIIDAFTDEAFAGNPAAVVLFDGDDRIEDVGLMQKLAIEYNLQETAFLRLQEPSDERSPRYRLRWFTPVQEFPLCGHATLASSHYLLDEVHPDADRITFETMSGPLTAARREPDLIELDFPADDSAVAPAEALDEATYSALMAQVNDELPAAIVAVRVAKLAVVVELTSDFNLADAKLDATCLATSSRYFVFTQICSGGAAHIYTRVLDGAEACPEDPVTGSAHCVLAPYFLDSSTAANGRLLRQHPELARKQSDAPSSLRCRQGGPRRGQLEVEWRWRDGRVLLRGNAVTVMEGNIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9X2</accession>
    <name>A0A2S5B9X2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9X2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="387" mass="41423" checksum="E543BC4A030AA344" modified="2018-07-18" version="1">MASGMSLSGTDPEQGMLVDPDVVALAARIEAMGTSGTAGIGSPDDESDAIAECFWEVAFGACEHCGRAAVNRNDMVQHDLQLELANPSCDSFKSSATETPLAGTLGVYQGLATSVPTAGETPTARERLVAAGIPDWMVDEFDVAWDDSNGVVLGLQSLDFDLERWAPDGFAWTTFEDGGRVVQGAPLDDARSPEEWRIALGAEITLVSDNIAAVTDFVEEVLETMLMNTEAHTYEVASRRAAYAKGKLEEPQPITLLFESNESHSYAYSRYLRTGEYVTEIDGLARLQLVNGDTVPVIQPYVFEDDTFSDLESRESGGGSSEEEETAALTDEASADGDSDGGGTDQLAPEVDDDLEMQAQPDEPAGETTADVIYSHAANESYSPMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA56</accession>
    <name>A0A2S5BA56_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_3183</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA56"/>
    <dbReference type="STRING" id="741276.A0A2S5BA56"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="221"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="302"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="60"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY73648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="359" mass="40434" checksum="792A65ABFBAA22F4" modified="2018-07-18" version="1">MPSMNRKSNGRRLADSDDEPMNGSDDDRDQQGDITDRILAKVDPEYLNTAIDLRQGDAALRKLIGALGSLRKEVKDVENTLSNVASEMAEMLSDELVDEEYNEDATLERLQAHSTMKELEKDFLATLDRAKEISIKSGTISDMRQRLTQGHQLTNIYQMYEKKVQEPLEKERTKTARQKYMKDCPSYEGYRQIVWENLTSNQAVPSIKRFLPRQDGDEESDDEEIEFGAQTSNFQCPITLGVLEDPYKSTVCPHAFSGAAIKEIIQQEKGSTRCPVAGCSKTITLATIEPDEQLARRVAAHVKRQKEGRTQASTQARTYTRMELSDEDGDDDDEDDAETQAARKIKKEVKKEKAAAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAC9</accession>
    <name>A0A2S5BAC9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAC9"/>
    <dbReference type="STRING" id="741276.A0A2S5BAC9"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="198" mass="22107" checksum="4883D29F66642A3D" modified="2018-07-18" version="1">MFRSGSSVLFTSARCAVPSTPAAGARSYASKPAQNSGSRLKAAQQASRGRKTVDMTGDGRVQVIKETLYESNPPEEDRIAALEKVIPSAEAHETILRAWQLHRRHKREAHSAEIARKYNAMRSAIDFLEETDRALWEKAVAGKKYQNVDQSGATNARLEGLVPREMRFPTELPAGKMWDYDWKAPQTQQETAPKRPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAH1</accession>
    <name>A0A2S5BAH1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAH1"/>
    <dbReference type="STRING" id="741276.A0A2S5BAH1"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="326" mass="36274" checksum="A3469A180510B3E7" modified="2018-07-18" version="1">MPKAARASTSSRKKRSSLNGNGNKPPRASTSKTTVEDADEVDARFAAFQAEHGASQDEDDAGAVESRDAAASEDATGGRPFEGAGEDDVELDERELLKRTTLPDHLLPRALVSGKKVKQPGLVYLSRLPPGMGPAQVRHLMSAYGEIGRIYLELADKEKGKQRKQKEGRHTSHNFKEGWVEFLDKRVARSVAEMLNAQPIGQNKRWKDDVWTMKYLPRFRWDQLSEQVALERATQASLLRFHLTHSKQENESYLAAVETNRVGKKIQEKAAGRKAAKGGVAATAEKGEADAGKKRKRDYRQREVVDVSQKLKRSEGDLDNVLGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAK5</accession>
    <name>A0A2S5BAK5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAK5"/>
    <dbReference type="OrthoDB" id="10277134at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32466" checksum="60CBAD67A16A4B28" modified="2018-07-18" version="1">MRDRLPTELVSLIITAAFQPTAWRRKALLDKLGLVCKSWRRFALVLAQETLEIDRASAVEVVCKWPAARRELIKTVLVGKEMHSREEHDDGFSTVVLDRLLFALPILEHAYMQNLDYTQAGIAVRVAPGCQAQKLRSLSICDAEIKILPAVDSAPLAVRRLRVQVNTTQNLDNLERLLRATSFPHLELLRLSSDTCLLALIVWQPDHRMFKTTTPTLFSFKHGIGEWPLTADPIVKYVQASLNDAGATSRGRYADGASNVKIVHDCPPLYDFVQPAFLDFLAQASGLSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAL1</accession>
    <name>A0A2S5BAL1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAL1"/>
    <dbReference type="OrthoDB" id="2529867at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="283" mass="30662" checksum="728C3C3C2FDA08D4" modified="2018-07-18" version="1">MPFALAPYLEPYGAYLRPAGYYATWSAFYLSYVISPGLVTLLQALILLLSWVLPTIETGVERARWNLLASRSAREDWAWPGRVPGQKTEWPAWAQTAFAYVDVRWVFVVGWLACVAKLRAFSRRMGWESKVAAPVVAPAPVRGPQPVAIVPSAARLPSQAPSARSNPFSTALPVGASVHASTVGGSTYRRRHSAQQIPRAPQAHSAVSTWRQETASALGSVHSRRSNPFSVAGQGTSSIPIRAPSARSAPHHGSAQPYSPLREPIYEDEHASIWSGSGGWKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAN2</accession>
    <name>A0A2S5BAN2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heparinase II/III-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAN2"/>
    <dbReference type="STRING" id="741276.A0A2S5BAN2"/>
    <dbReference type="OrthoDB" id="3476529at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045:SF1">
        <property type="entry name" value="HEPARINASE II_III-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Heparinase II/III-like C-terminal" evidence="4">
        <location>
            <begin position="551"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="828" mass="90383" checksum="3F57159DF680EB42" modified="2018-07-18" version="1">MYRQSADSAVPLQTFNYQQAPGQESYADLHNKQGQYPTGSSNVKRNGGRRKWPWVLGAILALVIILGAVLGGVFGSRAANNNNKNNSANGGNANAAAAGTSGAVDPASRTKGSGNEAVVPTATDAYGNPLYPTTTGSAVIAQPTVVSNAALQCPKEDTSGYSLTSPKKTHPLLIATETKWNCLPGLIEADSYMSYWNQTAFINATKFYNEPPVLYIADGGLGGSGLLDPARRVQQRIKHWAYAYKLSNDTKWVDRTWQELLVASGNTSTYYGQNNTNGDVWNCQQHFLDCAEYTEAFALAYDWMYDAWNQTQRDGIMWSIINKGLSFGLNVFEAPTGAGANYQWWSSVDGNWNCVCNKGMTMGALAIINEDPTNSAAKMLTYTVPNANAYCSYSPSPDGTWAETPNYWYFGTYSHVEMAASLLSATGSTQNLLDSNPGMKDSAKYHMYVTGLQGMFDYGDAGPNKYTATANGIMFYGDQYARARCCWERGLTRNYLAGIPAYTLFQRDRGDAPEPMSLLYYNPQVKGEFWDGLALDNYFSNATDGWFSARSSWTDQQGTYIAMKAGGLLGHQTHGDLDAGDFVLDAMGQRWAGELGSGDYLSNGYFSSEDQASARWLYYRKRTEGQNTFTINDNNQVVTGIPTHQYGSTGESQDALDYAPANSSTVFFTTDLSEMYNSTTSAKRGIRYLNGRRQVLLRDEINTSGTIQWRMHTNATVTLSDNNMTASLALGGETLVATLRSPSGAAFSTQEPAARLSSDPTTTVNNGQTWNMSPDQPNPGVTVLMIELAAGDQTIEVLFNPQWSGWSQSSYVNPPSIALASWSLTSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAP2</accession>
    <name>A0A2S5BAP2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAP2"/>
    <dbReference type="STRING" id="741276.A0A2S5BAP2"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="6">
        <location>
            <begin position="179"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="836" mass="89406" checksum="1447F4AF3A879527" modified="2018-07-18" version="1" fragment="single">PQLPTHSFPREHRCIRQLLGWPPDPHSFQLCPRLPSALFAEHQLNQLESHKAKLKLGKGKLAATNATNTSIASKGIALPTQSLSTGGSKGGEPTSRRNLTVAELLVQSRHYSTPVKKQALQEMTDLVTAHPDLVQRHLLPLTTALAHLVADASASVRLLVRQLVAHVAATLPHASFVQVCAPPIVLFTLAALSSLEDPIRIDALRLVDTLLAAIPTELVRDFDPAEVQSTESEAHGPRILDALLSLLKVRAPTSAATQVLNGGMTAAKAATLSDLSPEARLAVLSTLETFLRAASARETATDDEPWYLAGAFDSHAAYLDFMAAHPLSSSSSSSSGAHHSIDTEVARSIAVEPFALTSGSLSLQELGLYAPGPVASTSAAQPSLLSLLHPTLLSSFLDSAPTALNPSVSTAATSTSDHLSTVTAVVSLARQLFTIELGGGAGGEQRSAARTNEARKLLVAFLTHASPYFPFGADALAATTASTKRPTAAQQAEEDKFLSLNLSFAELSSLLVLSTPTTTRGYEVDSAGRKLDRQFDRQLDKKGKSRKDVEAVVLERVQEWVVQALRGELSTASSPMGLTLSPTSFLSLTPTLWALLNQSDTVRSIEVFSAAVDYLARQNTNASYEGQTGLAKRRAMEFTARCVLVHSSPSYTAPFDLSPLASRLPESLSPNSKDVKQNALARWLVMLPKYLWELGGNGSSPPREDELRLVLTVLLELVQQGDKGLISPSVSFDQRRRVSTRADESRTKQTLASLSPLLSPFFHLVHPKSRAAVPGPFTRLSESSLASRQALDLVFTLSRDGSAATGGLVQAVDKACELRGGALAQRWTSLRASTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBP4</accession>
    <name>A0A2S5BBP4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBP4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="323" mass="35016" checksum="5274361D62EDCA20" modified="2018-07-18" version="1">MSAVSQSTGKNAAERLMAEIHAGQTSRETSRELARPSIQYEDEERLISSDEDGYGAPVSVDCRAAVDDKDDSEEDIKSGNGSQVPAASTATSEGARPLKRSRLDAEGAPPGSAAFTSCSCQSTSESVMSKPQPVVTADPQESEEIALLREEVNVLEAEIERLDYEGSRSLADVKKLEDRVKHSVTADKVRLQAENARLGEQATKHAAEMQQKELVRASAVASSHQAQIVMNQALNALATHKTRLAELEKARDDVKKQFETYRTGARRAALETLQAVARAEGVWEVSVTRKRAPGVELTVEDLERVFESAVKATDAVKPLLLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC36</accession>
    <name>A0A2S5BC36_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC36"/>
    <dbReference type="OrthoDB" id="2525208at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="173" mass="18856" checksum="65A054637488B21B" modified="2018-07-18" version="1">MPNVYKRGGVAAGDAGNNPTQTTYGNEPPKSTYPTVAGSYGGFVGVFVGTGIFILLVLLCLGFLRWRQLKRQAASREGAASVTGYEQRPGDDEWTAADEAFEMPSYEGRYDASTVNLGSPGPGQEPPLYAHDGVSQDAFFDDKRHQAYQDPYDDDDSIPRRADASREPRARPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC37</accession>
    <name>A0A2S5BC37_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OPA3-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC37"/>
    <dbReference type="STRING" id="741276.A0A2S5BC37"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28769" checksum="50DE92F9556E2E16" modified="2018-07-18" version="1">MASLKIASLFLRTLSKPIATKIKQQAKEHDGFKTRTIKMAQWLHRAEMNLRVKLLGESPRHIRPLSETKAIESGANFLSEGFLFSVAATIIIGETWRARRAENKRRDGVKEALEQHDAQILELEARIARDREREEESIRRERELEKVVEEIVSIGLRGGFGDLSDEWKKHLAMGELASRFRKAGRLLPGEDDTEDDDDDIDNITSAPSPAARSLEPLKQAAKDDVDTFRKAAEAILSEGSQTPAPPPTPTLPSSQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC48</accession>
    <name>A0A2S5BC48_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC48"/>
    <dbReference type="STRING" id="741276.A0A2S5BC48"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="311" mass="33494" checksum="7B845885321DB463" modified="2018-07-18" version="1">MKIGIFGGNGFVGSAVARKAVARGWKVVSFSRSGKAFQTPAGHTPAWAEEVEWRKASAFDPTTYEAELPSCDALVSTLGILFEADYKSQGQARPLAVLKAIAESATGSRGNPLAKQTDRSYERINRDSALSLYHAFHQSRAAASAEPSPFVFISAADIFRPFVPQRYISTKRAAEAAIWQRAQAEKADRPVRPILMRPSLMYHPHLAPSSTFPATLLEASSTVHQYIPPALRFAPAYRSPRQPAEAVPSAFQSFASLLSVPPIHVDAVGEAVCRSIAAPEVDGVVDVARMRQMLGFDPATPPHAAADGQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC82</accession>
    <name>A0A2S5BC82_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_2574</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC82"/>
    <dbReference type="STRING" id="741276.A0A2S5BC82"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="206"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY74380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="539" mass="57707" checksum="3BD0D0BAB483CCED" modified="2018-07-18" version="1">MLRSAQVKVLNRGALRAARKNAAVFQAARTLATKAASPAVVPSALPRAANLRASAPRSYATAAKNQVGKVKQVIGAVVDVQFDGDDLPPILNALEVQGFEHRLVLEVAMHLGENTVRTIAMDGTEGLVRGQDVVDSGAPIQIPVGPGCLGRIINVIGEPIDERGPIKAVKTLPIHADPPAYVDQSTAPEVLETGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIQELINNIAKAHGGYSVFTGVGERTREGNDLYHEMIETGVIQLENDNSKCALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLSTDMGGMQERITTTKKGSITCVQAVYVPADDLTDPAPATTFAHLDATTTLSRGIAELGIYPAVDPLDSKSRMLDPRIVGQEHYDTATQVQKLLQDYKGLQDIIAILGMDELSEADKLTVERARKVQRFMSQPFAVAEAFTGMEGRLVALKETVKSFQRILAGEFDHLPENAFYMVGDIADAEKKAEKLAAEMAEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCI6</accession>
    <name>A0A2S5BCI6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCI6"/>
    <dbReference type="OrthoDB" id="2530423at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="223" mass="24038" checksum="70038110D45D8DB0" modified="2018-07-18" version="1">MSYDAPRPYRPQLASPTSYDSLRAPPSITTWSDASLSSLGEPGKDRYSVNGRQTPPLSPPALASYPHPPQRYAGPQAPTTTSERPHRPAMLHKPSPKWVRGGNGLVMPELPAPSPVQQAPLQQYPSNAPMPYMAAQYAPGGPQPQLLAGGGRQQPPRPPPPPPPPQRVHEKPGKYSVKMGGTGILERKEPGHQKLKRVLFMSIAGLLVLAIIALIVLGCMKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCV1</accession>
    <name>A0A2S5BCV1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCV1"/>
    <dbReference type="STRING" id="741276.A0A2S5BCV1"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14618" checksum="8D7865FAE74253F9" modified="2018-07-18" version="1">MSSPQLKVRASELQNKKRDELVKQLEELKTELVSLRVQKIAGGNASKLARISTVRKSIARVLTVINLKTRANLRELYKGKKLPLDMRAKKTRAIRRRLTKHERTKTTERAHKKAIHFPKRQFIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD23</accession>
    <name>A0A2S5BD23_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD23"/>
    <dbReference type="STRING" id="741276.A0A2S5BD23"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="306"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="430" mass="46902" checksum="12D495C4D31C1C3D" modified="2018-07-18" version="1">MASGPLPPPVPTVPSSQNDDDDPFGNFDNVPLFMKSLPKELGGTADLKPLKEGETNPANTLAALQALAYEGDPSEIAEGFRQQGNDLFKRKKFRDAIGFYSRALDEVGKDLSIEERRGLWGNRAAANLELGNYGACLRDCSSVLGQTNSSYPDPPSDASNRSTMKALRRSARALSALDKLPEAIDALDRLRLLESEIGESDKDFGKGVRDEVERKKATRERKEAERVERERRKREGDAAVVLALSQRGVVFPKPTPKAALFANCPTDITPPHFDPDVVPLTSLDSVPLLPPSAGSSDYSPWQPPPPETPLIFPVFLLLPLETPPTRDLIMAFPEDATFGDALASMGRDTSTTQLYFATKRNRVLKIGPKLTLGKVLAAAGKVKEGEQPDGWELREGWAFEMVGVPKTSAGDEWVQNWKKELQSGAAPAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD27</accession>
    <name>A0A2S5BD27_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component Sec10-like alpha-helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD27"/>
    <dbReference type="STRING" id="741276.A0A2S5BD27"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="2">
        <location>
            <begin position="448"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1210" mass="130041" checksum="B9659EF2CF331B4A" modified="2018-07-18" version="1">MERWSALMPDRASTGGGPSHSHSRSRYHLRTSRGLIPLPAYPSRSQLIGPFPAEAWIVVMQFLPVPDLPQLLLCNKKLAALGKDDRLWRVKLAWLDYKGPGAILGWRDRGSKGHSTASLGLKSEEKGSAAQEPYRDEAPAIARSTIGSIPPPSAAATSAADVEDDFGDFLDVGEDDDETAVGASRRTRSGAAGDEDGFGAFQDPDGAGNDPFGLADGFSDISLEPTRPGPAAGPSSQSGTFAAAAADDLLVLFDDEADGVLAASQGTLSGVAAQDTHHEADSAGTPVDGRSRASTLSLRRPPAVSHLTFATPPVLASPTLVDPADRSAGAASTSSGGTFSFSQGTWTDEGSASTVADGLTPPVARAALGSRTHSSASSMGFPVPVATSTPAASDPEPAQQDAAVIGPLLHVYQKHVSLLLPFYTSLQTQSTSSLVFTVSPPLSPRLRARLLASLLRFTHPLCAPTRSRPQRVTVQRNIQSATDFFESTLLAEFARADDGTGAGLGKAEGGRDEEVMKDKAAILWELNASTTLSQVFVQKRETLFGSGHDPLRNLVKITTPSGTRSDGIDFSAMDEFMTSTLAILTSEGSLIARVFPPEADVLLYFLERVANDVVSDYITSLLAAAQPLQHPLFLLATAATFGQVYRLVDKVLEIEPKNERVTKDRAEDVVFRMFEPLMDDYLQEEGEWIRQVLEGTCEEWDRKTAHDLAVSDPTFLASQNPAQVKRNVLAGFTKVLLLPVTIIPKTAEFGLNAITYGATGVIDTFASLGNQLSNVAAPSSSSAAAKHQRNASVNSMTAPTASAMESTAEASAPASIYPNVPIESSAEAWGGGAPETDLAPGRLSIDANGHIGLVNETASAAASVPSPASAAIPTRTAPGRFDRLQLLLSLDTALQLIQADRDSLKRIQTFTRYPGVYGRKVRDAIEEVFLVLLQVLSEKHVCPAFAQATQQMAAYRPADHEDEAAVAPLVQFFELVHIGDTIQQMVDVYFDKEMATYIDRRDFLNAVVREKKKFEAALDDAVAQGLNAAVNILMASVEHLIATRQGLRDFTPDRDDDFDLAPTRACTAAIETLKQHCDMLRGSTDKQILEVFNQEVGIRLHGILLKHLKRQIVSTQGGLRLIADLNAYHSFVSSLRQPQVTAYFTSLKMVGELFLIDDPKELGALVRDTSRYEGTLSQEDLYELVQRRADWQKIERLVDKAVYGLECVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDD2</accession>
    <name>A0A2S5BDD2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDD2"/>
    <dbReference type="STRING" id="741276.A0A2S5BDD2"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="249"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="710" mass="77737" checksum="8DE304775C89A4CB" modified="2018-07-18" version="1">MDVQALSQRLSTLGVSSSSSAPAALLSTYFFTPKSGSKHPDNAEQDLKLVVVALEDAKNVGPAKILAAQVGLKDMRAVSGADLEKLLGRTRDQASPLSLPPSLAPSTLVITSNSLPSASAVSVPSPSDPSSALVLAAADFRKVVDQLKQEGAAVKEAEFAVKGAEPAAPAAAAAAAPAAAKSADKNAPSAAAARQAELEGQAGVQLGLTVKKEQAVFGDWYQQVLIKGDMLDYYDISGCYILKPWSYGIWQEIQTWFDTRIKALGVNNAYFPMFVSSTVLEREKDHIEGFAPEVAWVTRAGKSELEVPIAIRPTSETVMYPYYAKWIRSHRDLPLKLNQWNSVVRWEFKNPQPFLRTREFLWQEGHTAFQTKPEADKEVLEILDLYRGVYEELLAVPVIPGVKSEKEKFAGGLYTTTVEGFIPTTGRGIQGGTSHCLGQNFSKMFNIVVEDPANPGGDKLHVWQNSWGLSTRTIGVMVMIHGDDKGLVLPPRVAQLQVVIVPTGITAKTSDEMRKSLEDEADRLAKELVKAGVKAKADLREGYTPGFKYNDWELKGVPIRLELGPKDFEKKSAMSVRRDNGVKAPLALSDLTTTIPKLLDTIHNDMLERARKTYNESIVKVEEWKELVPTLNQNKVVVLPWCEVEKCEDEIKKRSAEESVSGAEDERAPSAGAKSLCIPHDQERFGSVEGKTCPNCGEKAKRWTLFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDD6</accession>
    <name>A0A2S5BDD6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDD6"/>
    <dbReference type="OrthoDB" id="10663423at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="910" mass="98731" checksum="89A36282A280CDFB" modified="2018-07-18" version="1">MQRGEPPAASAPAGEAQSSAAPLHRDEPSRRAHEDDDMVRSLAKPLPPTPASAMPSRRPGPRKRERALAASLTGRVAERGHSEASTWASSPFLVTRSSRDQCDVVVPPRGPVAAPAPHGETSSQELDAPLPTEPASRQQSHRRRSLSVPDLRARGRQQRQELPPVPFRSQSRARSIRSLVPPSLRSRKDPGSSSSSPCQHRTNGTPKSRYRVTGGFYASLMTPRPDVFLAGASSASEADSDISSEPDLIIQMPNSSSPAPSRPLRFVETRNRLRPCSSDDEAERSSMQRVLREMDESQAERAAWSDSAIRGVAYSLSARLAERDARRARRRLRQSSGEVRPRTRSRTASRRAAGGATDSETDSAPSWRADKGLFSRRTTPRRTPGRGRRSVTTQPLVLPRGPADSVPQESPPVPTSFQPFHFPGPRSSRSTSARASEDGPRTSLSQSLRRFARRPDSKVRASHSMSTLNEGAPRHVLGRPIRHVRQAASTSTTHSLPFAPPFTNAKGYWNDSLGECSGEAISTPQRFGSPGRKASVVSQNAFLTLPPHLHHLLRTPVDSGVPQSRPTADSFEQPFASPSARQAAELALLLAERLGEDSPASPQQTPQPARCPRSHPFAKAADLDTAPVDPMDAADALEHESTPRSISSDLPVFEDLSNLFWKPGATRSSSPTPRAQRPAPNPVQQQPWPATSFGRVYLGDSYQGDPFTTSRDPDSPQPSKHSHESFLVFGRDEVGGDSDSHGCVSPSSFIDLDYDFDPHLFALKRASVLSAEQQHEPQANAIRSSTGSRIERLSIDSRFFLSPSQPLASPYMSSDASRNSTLNGRLEDFPAPPSSLPHAFSETSHEGGSATRSAAMNIVPDRDEEQRNKRGPGRMDSRLAGGHPADLEGTARRSTGSAESAWFADSPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDH7</accession>
    <name>A0A2S5BDH7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Omega-class glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDH7"/>
    <dbReference type="STRING" id="741276.A0A2S5BDH7"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="228"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="390" mass="44472" checksum="4718E5DF0468057D" modified="2018-07-18" version="1">MLLRALSATTRSSVHTVTRPQSRLVSIQAAARCPTPRSVITPITLARHSTSDRTANMSSQAQKDITSWASKDGQFRRQTSSFRDSISKDGQFTPDEGRYHLYVSLACPWAHRTLIARSLKGLDKYVSVTVVHSFMGALGWSFYPPVRDEDGGFPQTKGQVGEPDGLAQVDGDPLFGAKFLRELYFKVDPDYSGRFTVPVLWDKKTNSIVNNESSEILRMFNTEFNHLLPKEQADIDLYPEHLRKEIDEQNEWVYDTVNNGVYKSGFATKPEAYESNVVPLFKSLDRLEKILDGGKQFVVGDQLTEADVRLYTTIVRFDPVYHGHFKCNLGSIRHDYPNLNRWCKNLYWNYDAFKSTTDFDHIKQHYYMSHGQINPTRIVPKGPLPPIEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDN8</accession>
    <name>A0A2S5BDN8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDN8"/>
    <dbReference type="STRING" id="741276.A0A2S5BDN8"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="7">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="530" mass="56397" checksum="E5F6640CED91779D" modified="2018-07-18" version="1">MLSLRGCTALPYLHRNAFRMASTSAHKDVFVAVADSQLASAAAADAIQADISQLWKTSNAKDKDSRTFYGVDGKTVVAVGVGKAQGKDENVLKEQTRRAAAVATHALKAANSKSFLIDPVHSAHAAAVGATLADFQWNLKTTSDAKAKLDKVEIAPLGDGKQTQVESDKAQGGRIGLDWETGRIYGEAQNFARVLMETPANRMTPTIFCETAQKQFEGVANVKLEAHDLKWAEERKMGSFISVSRGSDEPLRFLELHYNGAANKDEAPLAFVGKGITFDSGGISLKPGAGMKDMRADMGGAATTLAATWAIAKLQIPINLVLCIPLTENMPSGKATKPGDIVVASNGVTIEASQPSRLVDNTDAEGRLALADALYYASSQFKPHTVVDVATLTGAMMISLGNQFSGVFTNSDSLWSELDTAGASERDRVWRMPLDEGYMSQINGTGMDLCNTGGRLGGACTAAIFLKRFVDGLIVDGSDSENQDGLIRWAHIDIAGTMDLAGGDGGYNLKGMTGRPVRTLVEFARRSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDP2</accession>
    <name>A0A2S5BDP2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDP2"/>
    <dbReference type="STRING" id="741276.A0A2S5BDP2"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="362" mass="39298" checksum="1219EFC62687E2FA" modified="2018-07-18" version="1">MQERFLRTACMQLSPCFKDWDASRRRADALLADLDADSIDLLVLPEMAFTGERGADVLPVAADQAAAYMLTSIRIKQAIASSPRRTSTRSRNWSAKGELLTGPLPPVRALPECAPARRIGCYVVIGLPIRDASEAAESTPIPERTYRNSVIIVSPEGSLVHVYHKTFLYGELTNDRADYLWAIAGPGFSAVDLPFPPSSPCRTRGHDGPTPATFRLVPAICMDLNMPTFESPFDAFELGTFASEHDADLVVGAMSWLDSEPPTAHEGVGTDEATDDPGSVTEWEQVRQVLSYWVLRLNPLIGSGAAFVCANRIGREGDVLFTGSSCAIELGDRPTVVEHAGKRTERLVLARVALPDKSGSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDY3</accession>
    <name>A0A2S5BDY3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDY3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDY3"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="164"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="346" mass="37791" checksum="35B6A40A72E32D72" modified="2018-07-18" version="1">MDISSVVGPILVGACLGSCACGIVLALAARYAARFSEDRLWIRFAVVTAVLFALLDAAVTCSWAYQWSVRLYGQPFGLLIRPWQLPSAIYFGAFTILACQHFFIYRLFAVSEQYRWWLAVPSSTCSIAGAAVAFYMASYVAQRPSMISLPSIGNVPWGWFGPTLTADLLITTSLLWFLNWGPRARLGVTPNASIRRIASSAARTNFLSFVLQLATCILYSRYNVTLNWFYLSPILNKIHIASFIATLNARQGNGPDSFDDYEHSSGGRGGPRSSRRSIGQLRSGISVHQDVTVATDAPDYAAATDSTSRFSDGIPLGAYKVHFDGEAGPEKGVAQVLTRVCGLERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE29</accession>
    <name>A0A2S5BE29_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE29"/>
    <dbReference type="STRING" id="741276.A0A2S5BE29"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="502" mass="56570" checksum="A61BD652F8EE0C17" modified="2018-07-18" version="1">MLVSASPPLHSRSTQSAYFAQPVASPSTSFADLSLASPPVSKGAEYKSRPEGPTPVGPNGQEVVEPAVARTLTRKPSRKGKEKEEMVVIVPDRPQTPQGMKKDVGLDDLPDIPLSPDHLPPAFPSGLKKHGMPPDIDETVDAEGRPRFVGNPDIRRDADEPILQENKRRFVLFPIQYHEIWAAYKQAEASFWTAEEMDISKDQFDWERLNEKEQHFIKHVLAFFAASDGIVNENLVERFSSEVQVAEARCFYGFQIMMENVHSEVYSLLIESYVRDPYERATLFNAIETIPCIKRKADWALRWISDPRAVFAERLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLFSHLERRPSPQRINQIITEAVEIEKEFLTDALPVALIGMNAILMRQYIEFVADRLLVALGNDKLYNAENPFDWMELISMEGKTNFFERRVSDYQKANVMSRHAAMSRTASLNPIGEASGSSTPHDDRSGLVLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE58</accession>
    <name>A0A2S5BE58_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE58"/>
    <dbReference type="STRING" id="741276.A0A2S5BE58"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="648"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="75294" checksum="EB6374DB39C326E2" modified="2018-07-18" version="1">MGAGASTQNGATGGAATSTSLDHYQILQIGETATQDEIKKAFRKVALKEHPDKNPHDIEGATKRFARVQAAYECLSDPQERAWYDDHRDDINNGGAAGGGGTTEAEASYFDAVRRGTQKPRARATPARGLQTPHLMKFFSTSAWSAFDDSPTGFFNTFATLFSLLAADETSWSSPHLYPSFGTSTTTDQADLRAFYQAWTNFSTEKDFAWKDLYKVEEEMPRWQRREIEKENQRARQTARREYNDAVRNLVLFVRRRDPRYTNSSSSAARAAAEAELRASLAAAARQRALEREAAASSYRAQDWEQADDKAEAVHAMWDEVSDEEDAAGEGEDGDGELIEEIVWCEACSKGYRSGGAWENHERSRKHGKNVERLIKEMQLEDEELGLGGASNARTPESDEDDLEPVASTSRSPSPDPASPGSRPRATAAEAAALADSLADLDLSQPATGEAALDFDDAPIPKRSKKKQRKKAQIVPGFDDDEDFEGGSGGTATPELPRGDDVDLDDVVGMAPSGGRRRKKGKGRQADFFADLDGSGAGQDDDEAVEVPVPLGLGRSGVGLDSSDEDRPSLRNARGKKKGRKAKQTPLAESRTPTTGDEARVETAPADTARGDLEQVDEPSALGDKELSKKEKRRLKEAAKKAGPGDDFVCNVCSESFPSRSKLFQHIDVTGHALAESAAAAGSGGKGGGRKKGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEK0</accession>
    <name>A0A2S5BEK0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEK0"/>
    <dbReference type="OrthoDB" id="10680889at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="688" mass="73159" checksum="66D25A055264C7AD" modified="2018-07-18" version="1">MAPYPVPDDANSLVLRGDPDLRVFVAVKNKPLPVFNLARAGDSGVQAFIPSAPGVVFEVVLYNGRKKPRKSPQLMELWFGPTFVRDWVLERDDFDYKLSSDAPERFFTFKSILDKERLFEFGPIPTTDAKGAKELDLAYLDTVSAIQVKTYTITYLTWNVDKAPKPKKEKKKAKRVVSHDVGGKKDGSGTRAVTAPADADVPVGANQGSEPAKGSVRAAVVDHAHDRVYRKHEKALLPIDETSDKGQFGLVPGFGPLLSRVDALDEPVPDGPQTDGAAAADVTGRPASPADPHVAAAAAAPAGNSSSATRAGKKPEKEKPEKWFVPKWKGQTLDGTYTFFLRSLPWISNHLDAFFFEPTPALPPPEPTVEIGDVIYVDTSEQDAAADAAASGPPKKRTKLTSGHDAETIGKRAQMSRGDDDNDVDVDVEMQIGDYGGHDEFEWNDRLEDAPQAPAEFAAQPVTAASKATDAFKTTIAMNSTNSIEHGAVLNGSGPPTAAAALIAFSQSGSASAPPVSLFDDAVRAPVSFTNAPSSTSSAYDASAVNIAGMDDADEPLDFMIDTPASDLLAASVYAPSAANSLFRRMVKQDPVLERLAEESMLALPSQIPSQPPAAEIDASCQIGSSRDLQAAALPSSAASGPVRATTKRTKTFQSRQPRKPSSTNGASDGGMPYRAGASNSSKRSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEY3</accession>
    <name>A0A2S5BEY3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase</fullName>
            <ecNumber evidence="9">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1692</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEY3"/>
    <dbReference type="STRING" id="741276.A0A2S5BEY3"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="11">
        <location>
            <begin position="86"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="8">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="448" mass="50521" checksum="3D58E212B7E54984" modified="2018-07-18" version="1" fragment="single">FDRGATRLHRRQDANPPLALAPKAPKELSLSALASLCSSYRMANEPSKADSFGDAASPVDGETDSLPSTRPAVPPLACMRYSRRPCPNQDLVDALKPLREWRFVEYGSSSPEGISYSTAISAIIACPYRLRSGEEARALHKVGEKLALKVDEFLDTGRIREADDLDHNERYQSLKSLMTVHGIGQHTAKELYSQGYRSAEDMRKSGHWQKEFRYHDDIQLPIPRTDVESIAQFVQLQVDRIERGSHMVITGGYRRGKLQSNDVDLLITFPHQDGKERKMLRRLCHRLQVKGFIPPDGILSFSEPATLRTTHENKKASSFDSLDKALVVFRHPANNTTRKRDIYRRVDLIFARWPSFGAAVLGWSGSTQFERDLRKHAERLGYKFDSGGLRVRGSNEVVPTMTEQDVFRALKLKYILPELPRRAGRPLTCGFWTVSAAGVSLRCRCVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEY5</accession>
    <name>A0A2S5BEY5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1566</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEY5"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015367950" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="579" mass="62579" checksum="67CDE5C55BD410B1" modified="2018-07-18" version="1">MRFTIVSLAALSLASSSLAAVVPRWHYALSCSDLWQAAPKMLPNLEVYIAEDVAAGSTLPANSPFSTPAYNQAVPDLPAFCRFGAYIHTSNMSKVQFEVWLPDVWSGRYAMVGNGGDAGGVNFPDMWAPLTKYNMVVASTDTGHNGTAFDPTFAINNPESQIDFGYRAVHLTTEYSKTILAAYYGKKQDYSYWLGCSSGGKQGLKEVQMFPHDYDGVVAGAAAQWYVFPSPKPAVPIPPAAKSRSREASWPHLNGYTYAVNAIVNPIGSAGHLNATDYATIAAEVMKQCDTLDGVQDGILTNAQLCHPDLSPLLCSAPNANATSCLSQAKIDTMKNIWGNWTAQTDAGYPKGTFLFPGFAVGAESNPFFSVTGQAFPPGPGYFQYQILNYTNPAVTYSGNESQTEYLVKLADEIDPGMTNAEDPNIGEFLKHGKLLTYVGGADVLIPTYSTTYYRKLVADALGNDNLDDTYRTFIAPGVSHCSGGRGADGFGGPGQRQDSLGGQSQPLVYDAHHDMTLAMFDWVEKGKAPDYIIAAKYNNNNKTQGVAFTRPLCPYPQFAKYIGGNTTEASSFECAYDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFD4</accession>
    <name>A0A2S5BFD4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ADP-specific phosphofructokinase</fullName>
            <ecNumber evidence="9">2.7.1.146</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.146" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFD4"/>
    <dbReference type="STRING" id="741276.A0A2S5BFD4"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043844">
        <property type="term" value="F:ADP-specific phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="216"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="345" mass="36140" checksum="C6B4383B59B84097" modified="2018-07-18" version="1">MSARLMQFRAGRAFRQGETNTVVPEAGRGLVYLQEEDGLLHFCYKNLETNQVDEDLIIFPGDASFANATPDRVHVLRFNSSSARHFFWHQDPQLDQAEFEQRGRRVNELIGAEPVDVAAPAAPAAGNMDVEPSSGDVAMSDAPASSTASDSTAFETPAVARTVPDSQTAAAAAAAPPGAPRKLGQAEQLAQLQSILAGLGGTSNTNAASLLQSATHSGGVPEFTLPDVLTPSAATSLIASLPDSSLSHLSSFLPTRVPTLPLSTPAEQRASLIRAVGSPEFRRALASLERALRTGATGPLVQGLGMQARAAHGTQEFLEEVQRQADQEREREGGGAGASEPGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFP1</accession>
    <name>A0A2S5BFP1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFP1"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32319" checksum="1432402298935465" modified="2018-07-18" version="1">MSAVSGVLHRASVSSVSSFEISSTVPVGDDNTRPLLLFVAGLGDTLLSVEYVIGVAAAVGEQGWRCAQALLSSNGPGWGTASVRQDAEELADLVRYFKRRGAAKVVLLGHSTGCQDAIAYLHLARDDAAMPQLDAVILQAPVSDREAPGVSEGVNRFLPQLEYQKDSPTFASPELASLLQTDIGITLHRFRSLVLPPTGDTVNLDVCEDFFSSDLSDLYLERVFAPTTCPIMFVLSGDDASYPERIKSRLPDLLQCFRRSTPEPYSSRHSCILPDADHSLSSVSSAEAFKQQVVAFLGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFR7</accession>
    <name>A0A2S5BFR7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFR7"/>
    <dbReference type="STRING" id="741276.A0A2S5BFR7"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="83819" checksum="4451752BF8389F14" modified="2018-07-18" version="1">MEGSETLYNKEDDEEARSADSPRTSDQSSRPLLYAFKARDGRQIMPSSKMLLPAQIGLIVFSTLSHQQTDPIADTEPGPLVLLPTAQYAVLSACAGLWAFRTKRKARAAGLRPPAASSSPTTDPPQGRSANAASQRRRAWIAGAAVAVAETVKAGQLSLKGPSRLDSTLETFTVAALLVYLLLPSSPFLHASQWRSIPSTRLIIFVSGLSFLLAFVLIGLPAVPASYAIGMLRAALLACSTALVKDGLCDQGSAAQFAQNAAVSALGVSLVGLPALRHLARDPIGLPDLQIVAQPLCVASAAQVMFYAVLHASTSAATPLLAVFARNFALLVSPSAMPAETSWSQRWTQLFVIYFIGSVLAFWIDADLRSVFSCGRRTASAGLADEEDEALALVDSAGHSARMPSSPPLHRHRDDDTTDASSTQASVRSRLIISLLPFLPLLLGAAVSPLSSRPFNASCAYLPDSIRSTVCPFFVPTVASNTVDIVMAYYDENLPDAQGLLTLLRQTPYVAARQERVVVYNKGLKSEQEIREGMALMEEDEVVPLPNLGREGGTYLSHILLHYNATVSSLAEGWQPTQAPVGDLAVSSKHLRRRTLADMTYFFQPHLAWGLIVEPRVQQVLEKTGFTNFGPNIRLECSYDTKAPVDISSPSRYLSLTLPSQMIESLYNMFRGKMCRKEEGQLGGWSAQMAVSKRRILDNPYARYAYVSELLSAPAGHWIHDQWGPNESGGPSNPAFGHAVERAWPAIFGCEDARIAKECPNEESAPEKCQCFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFS8</accession>
    <name>A0A2S5BFS8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TFIID subunit TAF5 NTD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFS8"/>
    <dbReference type="STRING" id="741276.A0A2S5BFS8"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="9">
        <location>
            <begin position="120"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="489"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="562"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="610"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="652"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="694"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="745"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="774"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="903"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="786"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="815"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="987" mass="104762" checksum="1C3A84154A81806A" modified="2018-07-18" version="1">MSSTPHPPAPQAGQQQSNPDANYRAILDYLSKRGHHKAALALQGDLDGTNSANAAAGGGKAVGLDDFAERNAPSAPRQGPPGAGPPTAAAGAAQNAQPQPAQGARKRMDQSVAPGQMLADPPSWERGYDGIRTFVDNSLDIHRPELHPLLLPLFVHSYLDLVLVGCRDAADHFLKRFARDHDAQYPQLVRLLASLRNPSHVAENESAKRWRNERYHVRLSERGWGLLLGWLQGGGLAGSTEGTEGRGRDRVLAIINERVKVDAVPGPPLASTLTSHGLGADYYSLQHNGAPPPGPGTTGHAAGAGKLPELKLGAAPVNPALDREVKRRLKDAGEADEDIEAADKRSRKKQQEENGMAVDDATGADEPVTSGGGGKATEPDTSDLVTPFPADLPPYPSTFRTLDVQREVELVREARKRIRLGAEAYAPEGALIPTTNGPGAVNGTGSGKIGAGLGVSMLGGDKDLPGGMAGDREDRRKGIGKPSVCLFTLHDTGDSLSTVTFSEDSTVMATGSTESYIRLWSLNGKGLRALRTDLTGDEVNKTTTAEAISKLYHPEAPQTRKLIAHSGPVYSLSFDPVPGPAGPPRFLLSASADCTVRLWSLETYTNLVVYRGHREPVWAVEWGPRGVYFATASRDRTARLWITDKINAVRIFAGHLSDVNCLSFHPNSLYLATGSSDRTCRLWDVQKGHCVRVFIGHRAAVQVVKVSPDGRYLASAGDDGLILLWSLATGQRVKTFWSHPEGATIQSLSWSCESTVLVSGASDETVRVWDVVTPPSSTGGDDAEGGLAGGQRAGEGVGGVKGRLAVLPRPGAGAKGKDGKDSDANRGDKGLGLVPRAQAGEGPCPDLLATLATKRTPIVEVKFTPRNLCLAAGPMRETSPAEKPPVLCEALQGRRELRDGLRGGQLLVFSSRSPSDNRQEPRSRPRLEKERGAPRGTELLVFSAAECMQVARAGRSTVATTAASLDWTARACPQSTKRVASCPSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG26</accession>
    <name>A0A2S5BG26_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG26"/>
    <dbReference type="STRING" id="741276.A0A2S5BG26"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="257" mass="27470" checksum="FC800AF820F0A279" modified="2018-07-18" version="1">MSTSLFNRASSLVSSFSRLAVSSSSSSSASPRSSIAVGRAGLPRTADSLFQPAHLLQVRNKSLVPRRTKYRKAHKGRVPLALGGSTKGTTLEWGDYGLRVNEPVRLSAKHLEVAEAALKRGLKPIRGSKVYMRVFPDIPVCIKGNETRMGKGKGTFEFWSCRARMGRVIFEIGGPNLRPEMAHAVMRLAAAKLPCTTEVIDKTSVARLGFDDVEPEKLAPRVTTLGEAQRKMQLASAAAAAAQPSAQAEAAAAIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGA6</accession>
    <name>A0A2S5BGA6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGA6"/>
    <dbReference type="OrthoDB" id="2524173at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="107" mass="11387" checksum="266545ADCA175DE9" modified="2018-07-18" version="1">MSVPAHHLDYAQSTYFVLSTSSSAPPPLPSSNSTSALSYIGPVGDGLMANEHIIALQNVPTGAADRSADVDRAKKELKGTAGVEHVEVMQAKQRRQVDRRSGSRVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGJ9</accession>
    <name>A0A2S5BGJ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGJ9"/>
    <dbReference type="STRING" id="741276.A0A2S5BGJ9"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="581"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="951"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1041"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1243" mass="135221" checksum="50B0BA8286B6424E" modified="2018-07-18" version="1">MSIPLVEDESEGSVQQTGRSQYEPEHAESPTPERRGSPTPGPAESANEAQQDDQEDEEQRDSEDTFYQLMSVQIDQPIGSMSISPANRDVALGSRTGLFIVDLQNPYDPPRFLPHASAWEVSDWNPFPSRSEWVCSTSNQQAVVYNLSLSPALSASPIEHALYGHRRAVTDINWSPGSPEVLATSSMDGWVMAWDLRTGYGSTGRGRKPIWRVSTWDSPATQVKFNRHEAHMIASAHGNVVHIWDDRMGATPVETVRGHSARIYGIDWSRKDPKQLITCSLDSSFKIDALSTPIRSVTTSAPIWRARWLPFGDGILTLPQRSDHALSIWSVKSIDESIKANEQPIASARFEGAREGVKERPTVPAHHDVGHVKGSRIEVPMTRRGGPDVSYRSFGEAPAPVTQLLDGTLTAKPTSPTGGSMLSATLASPPAPSLLTSSILNASLSNTAANKEHFVPHPISLAAGAETATMTTTKVRTRRQKEHDRLAWMEGVKILRAPEEANEAEGDGEGYSGEPSERPGSVAAPSQPPTRASSVLRGTDAGTITAREGEDTERAESIMSRESLHTGTAIGKDNEYATFGEEITSVVRRFPRVNFEKVHVAGRSCTVSLYSPLFIRATFNFPRAYPASAPPQIELERSVDLTLKQRANILQGVRRLMTLRAERGLSSFEQALRFLSGDRTVENIEEEEEEDDEAEDGLDLAATTTLGADLLRNNINVPPPRRGGACFGPSGQLVVFFPTDVLAEPEPEEFFDSPDDEADASRRGFPLRLSDAFGSIAETADFAGDYQETDEALQLSTLRGMRRATSRDERKRLRQPSPPISAAFSTTVKIKDVSHLTIVHPERHHCDLTASVIDVARSSALGAMAAGDQLLAKLWTTVLACFESGLHGQQASVAAPLESLTAEHVLQEALKFLVALRDVQTLGVIAYLEEMIRSQQAARASEDYFSQRHRPIDPINVVEGGSGERTPLPTSASLGRRRSDPSRSPRPSWANLTGFFNTGMLSLRSNSPASPPPSASARREPRAPPPSGYNSPAVPSPQTPKSPLRTSLSAGSTASAEYSANQRPAVTFGPTSVAVLSPKPTGGDLAAASSASSRKRVLVAFADAPRFLSCWWLSPRSQVELELIRLTYAELLYRWGMHNERARVLKLCRSATTGAQGRQGVSEALLRDANGLGRDSTIDAPILCRLRHCAQPHRASLLEMFTSTALRPLRPLSPAGARSHAELQCLPASRTPRLSRAVVVGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGR5</accession>
    <name>A0A2S5BGR5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGR5"/>
    <dbReference type="STRING" id="741276.A0A2S5BGR5"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF88">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="349"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1262" mass="137087" checksum="40B3D84CBE9BFF56" modified="2018-07-18" version="1">MLAVAAPTASDDWLARTLGLRTTERARRLPSKAPRRLRKAPSLASPTSAPPQRIFLTRIAADCHPMPEGQASHDRHPPNQEQLRGPEKVAGGSGMAGDAQSSSASSHLDPNAFDPSAIPQPHSGFGSGVTRASQGVPSPGEGNDARGGTASDSANGVLDEPEKEQSDQAQHHQPSLFSTATATTPISFSSHPALRPQGLPFRYDAGGGVNPGAGFLAETWPDPLQQFRYPNAAENVFLPEGVDLTAFSELAHFDDLAMPTPPSGLMGYDANTEPSVSGSSTDPSRNNSIVSNTASAGTMPFSDLHPFPPFPLAAQPSGRAADDSSWANGYLPLPVLASLIASANSTLEPFSSSSPSMLPSGSRTATSSAGPVDAGGPSSGSSAPSNTRADSGTSDDRSRSGSGVEASGSRTGRNGSGGNGTSRLPGTGGNGDGSDSDDEGQEDDSGKRKRDPDSAGGKKLVQRADKSCRKCRERRVRCDRLWPACERCHKRRERCVWAEGTNVDEVEEGGDAERIAGLQNKVAYLERQLKAAQSGRQNSQTGSGSGSGSGSAAPTDVPAARKSDRPPQQIELGRERLPLAASPSEEPTLAASIWTMIRDIWALRMKLNPEETNTLLQYLAAQTCAPYAGQLELGRGNIHWRLAEPLMARVLTIHLLNAAVRACCSRLPGLQPLAQRIEQYKRNLDKLRPAEECAVAVLAALGARASPHSQLLGIDTLCLADGTPSPPLFLYAGERREMACRQLEARARELCWSHGFFENLEIEQLDSAVGLVQLLIYEEIRPKQSRYFARSALGLYFDIRYNDMEKGERTSADPRIGPGAALFLADATIAAACNRPSFISTTELDQYIVTDGVHIPDFPGSELETELQRILQAPLTTQKLVEAMSTVMMWAGGCHRLFAQLSTARRPDAPSTLPLLKSLWKLIDKVHTAVQNLQQFLVSLKPEDIVDGDQDRFALEHFILMGVRYDMLLVDVVNLQHAYLMRSRKEGVWAEREDDQLLLEMREESMLRVRKCLKLSAFYAQLYIQSQDKHLVHHMLMQLEMLPDWSVWAAQRVGTSGGPISPEYELSEMELDWLQQALELSSYYTPKAARRLEAFAKARGKLSDDGPRTLEELLRQNGEALRQPVAELQSQYQTAILEQASTYRPEVLYSRPQDIPPSLHHLPVNEDPQRYYNVNGHPFAPSASEIFVFDDYGVVSSQGLPLAQQPPIASLPFVQHGFQTHTSWMNLPHDFPTATGNDFAREAGTAEEMSDRWLGGQSDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGR8</accession>
    <name>A0A2S5BGR8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGR8"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="532" mass="55106" checksum="003CB619B2421B8C" modified="2018-07-18" version="1">MLSSRSYAMDRLHYSSEDDDHLDDERDRGCYVVWKSTSVLEAYPALVAPPPQPVLHRSGAPEPSLATGTTPRTKRTTTNAALPSPTAVLVDDSESPEGPPGASTSASASSSSRQAKKRRNMSSRRAAVAARQAMATAAAEPLDARTLEMVSQLGKKLQARTAAATTPRQPSTGLRVTPSASGGTSSVSGRRDPSNTGPPTRSGSAVAPARSPLRQSMLSTNASTAQGSTPLRQTPARMARQQQQTLSLSATKANLFATAKTGSSSRSKASVVIPDPKAHSPEVLVPPTPTYRSTTLASAAGNQTRIGTVQPSRPAVAIEDDVDYFEGDESFELALSQLDERLLVPSPPAAPAPAPPPQSKAGPASASRPLAMPDAAGSKGPVVGVAIKGSVPTVTAPRSVRAPSPRVRGPLISTSNPLRPPAQRVGSAGSIAVAAGAAVVGSKPYGARHASTSFAAVTTTTNVRSHPKAAPPPSKTAATLFVRTSGSCRLQTSAARGVDRLAMEELARKEIEALGMMGEEEESMLWGDDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGU3</accession>
    <name>A0A2S5BGU3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGU3"/>
    <dbReference type="STRING" id="741276.A0A2S5BGU3"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="38816" checksum="76BAB14711513E92" modified="2018-07-18" version="1">MHRATQAEAGDHVVERMVRQIVYEHKPLAYVLGTQPFHPLPVDLLVRPPTLIPRPETEHWVNELTKRITAAHGDADRPDAAGKPFRILDVGTGTGCIALGLTYGLAQAWVEHPNRVQTVAVDQSEQALELARENTLRCGLLASSRVDNAAVLKQASEVVLQKADLFSPTFSSSVSAALPPATASPSGTPDAGHDEVTKRFDLVVSNPPYIPLCDYLSLEANVRDWEDRRALVGEAPAGALVDPAPASPGPQSQSDDGLVFYRKIVSVLHEILAMPETVGSPEEAPVVAFEVGKGQARAVAELLAEWRSPGKSHIRPALRLDPEIIADPWGVERAVFARWRPHVGDRDGHPRKEVGQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGV6</accession>
    <name>A0A2S5BGV6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGV6"/>
    <dbReference type="OrthoDB" id="2528353at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="292" mass="30211" checksum="4D4C6D3B984C752E" modified="2018-07-18" version="1">MSVVVEPIRPFTSSSPPSSSFARSHSRSAFYAAPAGIMASDSAAPPQQQQHHHFPTSHAPQPSPSSAAVDEDDLLALLNNDLAIDSKRDRELVVLSSFLKGVLPPAAGAVAHPLPPNLTSNVTIGNAATAQHYGGWNGWRPTGEGIAAPFGSPMSFASTSSAMSGMPPGPSTSFGSAFSPSSIPSSHPFASPKNHFIAGSPAAAAQRSPFGRPGIAQQAMPPGARAPACSRERVPTLASFSDQNRAAAAPPVVSQPEEGGWKGRLRSSKARQPSADRGRPVAPTVEEDVMME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH06</accession>
    <name>A0A2S5BH06_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH06"/>
    <dbReference type="STRING" id="741276.A0A2S5BH06"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="351"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="387" mass="41374" checksum="FDBB73E2C6F9E424" modified="2018-07-18" version="1">MQAQLLNLSFAIRLTRAVSKRPQSESTALLKRQRTGDQDPSLQELIVAAPDATSTKGALIQTVKRTSGLTAPIMCLRGHQAEVLDVQFSPDGDSLATASADKTILLWRVYGDCQNYGALRLGKGTPTSIAYASPTTLVAGSSDHTLFLFDLKTGEVVRRFRGHKGVVNSVDVQAGRGLIASASDDGTVRVWSEDAKEELEVVELGYPITAVKWSEDGQSLFIAGLDNDVHVFSLTTHAISYTLRSHSDTVTSLALSPANSQLLSCGMDSTLHLWSVQPFAPTINTANPALHPRLVRSFYGAPAGFEQLLRRASFSRHTSPEGQKGTMVAAGGADRAVTVWDTTTGEIRYKLPGHTGTVISTAWSPKEPILASGGVEGVVYLGEVDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH36</accession>
    <name>A0A2S5BH36_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH36"/>
    <dbReference type="STRING" id="741276.A0A2S5BH36"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="287" mass="31808" checksum="1B66EED08B89FAF6" modified="2018-07-18" version="1">MVALFTTAFAFSYPWPAQTYAVLNKYPNPLAPHVISIDVVDRSILPDGTVRSERILGIQQDSPRWIRRILRTPDVTYAREVSFIVPASTAHPHAEPSTPPSQILLEPPKLLMASTNLSLSSLLQCRETISYLPHPWPHLPLPTRKQFAPKLRLTVRNGDSDNGDDDEGEDDLPDENENEPYPSPATTDHPLSHPTMPPSTLFSQSALIFSTGVLATESYPPHGISVESPIEPETLPAATTYPQRAAGRKVEEYSRDRFEQNAQGGRAAMEWAAGKLWRDIETPEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH41</accession>
    <name>A0A2S5BH41_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH41"/>
    <dbReference type="STRING" id="741276.A0A2S5BH41"/>
    <dbReference type="OrthoDB" id="2530497at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="611" mass="65752" checksum="D2A9916D0011FC06" modified="2018-07-18" version="1">MARPPPPPPAASLDHSTAQQHQQSGLASTSNPKQHRPSPRKRQLPADAYTAVEHVNASIPTSSPSIRALHRQQLATVVKSLAPGVVLEQHLTVPGAPSSLLDALADSAPLLPLSVLRACVNEACTSALLSSAMALDAPSQQDSATLLNDVDRFQEATLAVLDELEGTYRREEATMNGGKVVAKREEDAEDIPPPSKIRRYMLHRTLVNGDDIFTSAAVLSDADLEAVSKLDDTDVIAVHPPPTASTSYALDPFLSQPESDQDAVPVPTVGEVTPRPFGWQSARHVAPVARVGAAPGLYGAEAALRKDPSFLDPLNPTRRPTVLLSYDSPFISSLAPTHDSTGATESYSRSASRALSQLRNRRWLDAALGKEEQEEEDAIVLSEQESETLRSLGVDIEALLAGPNSRKQRTATPNRPRAPRPRERKPVADSSASSRDAEAAIWTRLEENAELIVRVARAQVARTRDSYDEELRRLRRRAEKAARIADRPVPAAGAPVKEEEKEAVLAGEEAPGEKAGRAELEDAKALLDSLVSLISSMPAKASSDSISTARVSPRIVPPPALLAKLAPLLMASRAKEPSYRGTLDPINDRAVKMRESVLPIMTGEMDIDVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH95</accession>
    <name>A0A2S5BH95_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH95"/>
    <dbReference type="STRING" id="741276.A0A2S5BH95"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="863" mass="91229" checksum="AE8BB67EC2BE4193" modified="2018-07-18" version="1">MDSDTTCSTSPPPIAAAKHAPVWDHSHASDKLGRDSASFSEPTLEVSADFGCVGDAFAADETLKAKVTLAPSPAPGSRAHSPGPLAWSEPGWSPGGFHFAPTATDHAAEGTNAFPDPVDVAGGPGSRKSSLGSADLHDPVEPEGASTDLVRKLCDTPTLDAKPVRSKLAPTAAPFAPKSTFTLAPSLAPAAPVSPEATTTTRSRPFPLELITSASRARRTAAALASGKSSSSMTSPSDPFPPAHTPLEEHSQFDEEGRLISHGAKYTIADEILQLQSTPMSPSFGQATQTGPNEATYGPATHRYRADSEQAAFTYAIENWRNGQDVVPNHSLASERHGLEQIPFPFTVPPFALPSERGRSLSLASALHAQGPLRPALERSNTVAQLQSYFGPPSPAAHTTRAGPERYRSSSQVFDYALSSSQELSRTPSCASLTGSFTLPYPPLAHPEPFNLTPDDALYIGARDLFVESSCSSLVGAPTMQHLETMAAHFDQAMQTLNPLASLYGLSQDAANHLLADPASSGVNEVVLKVAAMRGRQQQMASVQRSAMGMPLPGPSPNNRKLNLYKTELCRSWEEKGSCRYGVKCQFAHGIHELREIARHPKFKSEICRTFWNQGSCPYGKRCCFIHAVPDANSTETAAYKTSAPSTRPVTPSRTQARMTSTAITGAPSRTFGPALSELIGSSGSAWSTQSSPSQQVRAEHDTFSTSALESSALFGLGLRERPGQAPPTYKDAPQSRLQRLAGLSAGPSSTSLSSLGSAFAAQTTTAAAPHARHDSAHSFFSNSSVSSAAAYSPLLARSGSTSSLSSVGGSPVLHRISKDWLSSPTHSTSTAHLDWPAVEELALDEPPYSAGAMLAQRFPRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHU4</accession>
    <name>A0A2S5BHU4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHU4"/>
    <dbReference type="STRING" id="741276.A0A2S5BHU4"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986:SF1">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="492" mass="52646" checksum="38891B2245E9F20A" modified="2018-07-18" version="1">MASSNLLTSDPVPCYVDGKPFTGAGSYKVLDPHSPESTLHSVSSITVDDIPKVMETATAAAKKWKRTSVVERRNIFLRAAKILRDRTPELAGVEFNETTSSQMWSGFEITLAADSIEETAATATLALRGEIATTDSHQRAYIERCPFGVVLGIAPWNAPVTLAQRAVLQPIMAGNAAILKTSEMSPRTHMIVAEIMHEAGLPAGVLSVVHVDPKDAPKVTEALIAHNAVRKVNFTGSTRVGSIVAQTCGKHLKPVVLELGGKAPAIVAEDANLELAAEAIKFGGLFHSGQICMATQTAIVHESVADQFLTLLTNKYPSASAKSPHDGSALRGLFTQASAERVKGAVDDALSKGAKIVAGENRVKGNVIQPVLLTGITEDMRIYREEMFAPVFSVLTYKTDEEAIQYANDHDYGLAASVFTQHVDRGYAIAREIDSGMVHINGATVHDAATMPHGGWKASGYGRFNGIEGIREFTQTKTITVNEPHPYPAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHW4</accession>
    <name>A0A2S5BHW4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger C2H2 LYAR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHW4"/>
    <dbReference type="STRING" id="741276.A0A2S5BHW4"/>
    <dbReference type="OrthoDB" id="2530005at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="254" mass="27272" checksum="CBB6B31455F90CA3" modified="2018-07-18" version="1">MVSFSCESCCDIMKKPKLDAHAQRCRGAQFTCIDCNTTFEGTAYRSHTSCVSEEQRYHKSVYKPPKGKGKNGQQQQQQQQQQQKPAVTAQPEASTSTAAPAPAASTNGTDSSKKRNREEEQAPKQDAEKKKEDAAASVVNGSADKTEAEASAGGEPDKKKKKKDKKKSKKDAESTESATPSSDAASAKPSIPEFLTSVVQPLLKADGDVSLANVRQKVVEAAKEKGLEVQAVEEQLWAGLKVGGKKGKVRAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI77</accession>
    <name>A0A2S5BI77_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0677</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI77"/>
    <dbReference type="STRING" id="741276.A0A2S5BI77"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="331"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="570" mass="59895" checksum="18A9A411A614763F" modified="2018-07-18" version="1">MGNSASKEKKANKKAAKAGGQPTGSATTTSSVSQPPPSNSASTAAGDAPQSAGAPVSGQYPDPAGQPDGAAPGGGTGGNLAPSRSRSSTTASASQLARIPTSSSSQQQSSAGGAGAVAGNGTGTASLTPSGSISDVPATQTILSNPNAATPTNSLTPTLSTTPVASSSGMNGLPPSGPIGLLSTSPTTVPNQGGTGLIGGASGIAGNNAANRQQTFDIDDMISRLLDAGYSGKVTKSVCLKNAEITAICQAAREVFLSQPTLIELSPPVKIVGDVHGQYSDLIRLFEMCGFPPSANYLFLGDYVDRGKQSLETILLLLCYKVKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFVDVFNCLPIAAVVASKIFCVHGGLSPSLSSMDDIRRISRPTDVPDYGLLNDLLWSDPSDTALDWEDNERGVSYCFGKSVIGAFLARYDFDLICRAHMVVEGRSGSMPRHTCCWGHVPPIGCTCKNLRLMESPSTDGYEFWNERTLVTIFSAPNYCGEFDNFGSVMSVSEDLLCAFELLKPLDTAQLKRELAKTRRRLSSSSSNASTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIA2</accession>
    <name>A0A2S5BIA2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="10">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_0686</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIA2"/>
    <dbReference type="STRING" id="741276.A0A2S5BIA2"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="556"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="508"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY76485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="633" mass="68290" checksum="A7E7742FF24C724C" modified="2018-07-18" version="1">MSAQPQVIVVGAGLSGLAAAHTLYEKGANVLVLEKNPFAGGNSTKATSGINGAGTKAQSKLGIKDSVAAFFADTKESARELARDDLIEVLTGRSGDAVNWLVERFDLDLSKVSRLGGHSFERTHRGGAQFPGMTITYALMEKLEDLAEAHPERVKFLKRANVRRLVRDGEEVVGCEYEYQGAQHTAHGPVILATGGYAADFAKDGLLAKYRPELLDLPTTNGEHCQGDGAKMAFEIGANGIDLDKVQVHPTGLVDPNEPDAKVKFLAAEALRGCGGLLLNKNGDRFCDELGHRDYVTGRIWEDNKMPVRLVLNGEASKEIEWHCKHYVGRGLMKRLETVEEVAKEMGISASKLQGTFDDYMEICKDPKKDPFGKKFFHNYNWKNEAGPFHVALMSPVLHYTMGGLEINARSEVLDSKKQPIAGLYASGEIAGGVHGANRLGGSSLLGCVVFGRVAGDSAASHLLKNLSSGSGTVARLGQVNGHLAAAPLSTTIQIDPSTQQVHLTFAWGGSAPGQSQPQNAGDVKPHGRSTPEQPANEKSAAVEHNEKTEKGEKQMKEYTVDEVAKHKSKDDCWVIIDGQVLDVTKFLPDHPGGAKAILLYAGRDATEEFDMLHNRNVIPKYAADTVIGKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIL4</accession>
    <name>A0A2S5BIL4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIL4"/>
    <dbReference type="STRING" id="741276.A0A2S5BIL4"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="737"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="771" mass="82510" checksum="270192E914F4DF00" modified="2018-07-18" version="1">MARRAKKAAATEAATEEPEEAVAATEMEQDRVDQAQADADDNASDQDGDENDQVDDDEDQDSDDDDDDDESSEEEEVYVEPNLATRSRRANAGARMAALIEDEASAKVEQDEMFKEEENDEEFAQKEEKDEFDSDFGSTDEGEGDEEDDEEAGERKLQNEAKEAKKARLRVQRRQRLRNRKLTAWAARGKKKGFQAPVHPFARQSKAARKAAERQPVASTSATTLDGDKQEPPKKRKKVAVDPAFLAPQRESSRRTAVEIRKQVQDRAKESEQRKATAPKQQRKAAVSLSQADLIAEALETEETNRAALLAFYAAEEDRREAERIAGMRYEIIGPKLTFLSRVQDRVDKGKEKEAAQVEKGRKRMIEVLGETGQKGWKGAAGDENASATAGSAAAARDDVPATTSTTPATLASILNPLDPNLSPSAAPEAPEYARNWLVFDNFEGGRAEELEAIFGDHIDWSKPAALPTRVTRKDMCPITGLPARYRDPQTLTPYATLAAYHATRAVVDAQAFVWSETLGAYTAAAHFGIMRDVEASWARRPQPPGALPRYAASTPYPAAKASTFGNIASSGTGVKVPRQRQPVSNENPYRVEYAHAGGSGRGQRGRSSLGATDNAATPPASAMHPVQVKPALPVPSPPAQLQQPPTPTLAPAPNGTTPHGLQPTIAPQHYNTDDVYRQPAAGASKPAVVTPLAEYANGPHSSPSLVGTSSAPQARSIQLGSGRAANSAFGGGGPSSTGAGSPMSPVPPVTGAAPGVALPLPGALPPLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIM3</accession>
    <name>A0A2S5BIM3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIM3"/>
    <dbReference type="STRING" id="741276.A0A2S5BIM3"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000122">
        <property type="entry name" value="Glycoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="68"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="7">
        <location>
            <begin position="639"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="92818" checksum="0F178F708935CFD4" modified="2018-07-18" version="1">MAPVPTKSPVTGHAVPEHYVHASSAHFRATDGRTVLLRGINLTSSAKTPRGQPGQKLEGFWEGAKSGDMSWVGRILELDEADEHLQRLKWWGFTCLRFVTTWEAIEHAGPGKYDTEYFDYVVALLRKCKEYGFRVYIDPHQDLWSRFSGGSGAPYWTILACGLEPQNFTKTRAAVIECEWPDAEHPDPASFPKMIWATNYARLAVQTIFTLFFAGREYAPKCIIDGVNIQDYLQEHFINAYRKLGEAIAKAGDLLDETVIGWDSLNEPNAGYVGVDDLSHHGKESVLRVGPMPTGLQAMRMGMGERMEVENWKSGPLGPKRDGSVVVDPQGTIAWLVPEAEPNGRSPWGWQRDPGWQLGTCLWAQHGVWNVETGEILKAAYFSECHGRPVEFGADFWLPFFLKWVPVVREVHPEAILFAHSPVFQIPPRIESPELKDRVAFSSHFYDGLTLITKHWNWFNADAIGILRGKYASVVLGVKVGEAAIRRCMRDQLGVLRQDGFDAIGQVPFMMGEIGIPYDLDDKRSYKTGNYAQQVRALDASLSACDGKNLMNYTTWCYCPDNCHLTGDRWNGEDLSVWSPDDILHPGSGPNGAASESSSGGSSPTDTKGRNSPASDAPLDPEHPINLNDGARGLPAFVRPYPLKTVGTPTNLEFDIKTSKFKLEVKVEADDVADADLPTEIYVPLSHYASHPQHMSFDVREADRRHRLTGTLRNPKAGDIGDETVVVGEGGDVNPPDDSARDLALKVKISAGRYELDAEKQLLRWYYPRPASGSMTATIEFERVGGAIPLWISQWYRGGFDRVEQKNWNGNFCSLVGVTLVGLIGVTVTATSFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIN1</accession>
    <name>A0A2S5BIN1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIN1"/>
    <dbReference type="STRING" id="741276.A0A2S5BIN1"/>
    <dbReference type="OrthoDB" id="2530288at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1073" mass="115573" checksum="FAA479BF4C0641CE" modified="2018-07-18" version="1">MAQDGRDVAMVDAFRSSEQAGNEQTPHETDVDQSTSSASRTGDEGPGTAAANREERPVTPLPPPPPASAGHKDEERSHSSQESIVAAPHSTGTSPPRPAKGNHLYLGSMPESPDPLLISPVASAASSAGRARAQADLRARSVSAEPGRGYLRSSPSRVVARQRSKTPSAKDVTGENADPASDEVLAAAPTPGQRRLSRPPEPDAGSDDQLAMSPLRAAPPRGKLQGRGDFVGVEIPPARRSRPTRPRNDTASPQGLHSRSPQVPDQSSSNTLPQAGSSARRTASFELIVDTPRAASRSPKTSPRASPVVRDDEAAIVRDFAAQHLSTSSSHPLSQVHSRESLAADSSPLTSIAATSPVRRHTPEPVASPTKRSRRKVKDATYTADSDDDGAETSSTVTNPSPKKKRKPRVSAARKTATAMGNRRTSTGRNRKKEEEAELDERSPSPTQANGDSTDLVLGKSDRPRRDRKGKAKAAEPEGEDIPPAVREAAAAANRSTRRRSAIKASYKEAGSGGSDEEEAEGGSTFESEPQETSPRKRRGRPRKTVESDTTPRAQADRKPKVKGRLARAAAAPESKRRAENPASGSDAPTPLSSPSKRNGLSAPEAFGSQSSSQGRASRQTAEQRKAGWSKYAFSVGQPLWVHVCPSGKHGFWWPGEITSTLLERPLKVKLYIDTAETVGAFSEESLSIGEPDHDTLATFRNPAKLRFDKYIFRDEDDAMSGSAPSDDAFAEVLEMAVEREAEADGEGDDDDDEEMLASPAAPEKASTRAPTARKGVKAKKPVEDASADELEGRPAPAQSDESDFDEILDVDDADSSFEVPFICLAFATHAWWPARCIAQVPGSPSKKGRGANRKFKVEFTDSSIKTLAPKSVLTPKQKKFFTVKLGETELALDSNYVARTKSFVTTDMLPVYQEIIDERYAYARDRNDDFFAGGQRRERLAQRSVFGELPDEVVEMVLEVISSWADGEGSADGRPRGSDRYNALSPVERVQYRADVLLPLAIIENYADDGALPDKADELLRQAGVTEPTEDECKLKGLAMAEADLDRRSVTKAVLAMRNARKNVRGSRKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIR0</accession>
    <name>A0A2S5BIR0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione reductase</fullName>
            <ecNumber evidence="9">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIR0"/>
    <dbReference type="STRING" id="741276.A0A2S5BIR0"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="122"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="10">
        <location>
            <begin position="480"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="586" mass="64539" checksum="740ACB911EC58EC3" modified="2018-07-18" version="1" fragment="single">RQTRPFSLSSSILRCYLHNCAGYSLVTRSKLAFAYAPISRSISTSAFGRQSARSVSAPVAGKLSLFTTGTAARSFHSPARFPSARITAGSTYSTLRNFITSTRTMAPVPFQSTAAEKGENHYDLIVIGGGSGGLGAARRAAQYGAKVAIIEETWRLGGTCVNVGCVPKKVMWHAADLSEKLHQANVYGFKVPEEANKIDWPTIKHKRDKYIERLNGIYERNVEKDKVEYITGHAKFEDKKTITVVPTYPESKAHGGADKERQYTADRFVVAVGGTPTLPKDIPGYEYGFHSDGFFYLEELPKRAVVVGAGYIAVELAGIFHTLGAETHLCIRHEKILKAFDPMLQDTLQNHMIKTGIHVHTNCNVEKVTTEVENPDLHKPFPKTIYTKEGEKIEADVLLWAIGRHSLTETLGADKIGLKLEKNGDIVVDEFQNTNVENVYAIGDVQGKALLTPVAIAAGRRLSNRLYGGVKDDKLSYDNIPTVVFSHPTIGTVGLTEPEAREKYGDDEIKIYKSSFTALYYSMMEQDDKEPTAIKLICAGKDEKVVGLHIIGMGSDEMLQGFAVAIKMGGTCIRYRPRAVRLSSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIX3</accession>
    <name>A0A2S5BIX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIX3"/>
    <dbReference type="OrthoDB" id="2520859at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="307" mass="34712" checksum="8257757B7E756D1E" modified="2018-07-18" version="1">MSTADLRAGGRAKGKSKRVAELGKTRALHARVCDFLAEPHHVGLLPLLAVNRHLRKLATKRLVAAYSKAVCKGWSEDGVTLKIVGGGFVRLTHNWVNPFNGPEKHDDPRYAITKHYPENAEYDELRPLDLIFDSFNADTRMCKFKPYNKFLDLQWNMDVDRTTRMPQPEFYAGVFNMTPTEWFRREQKGEQGVKGLLLAIDPTAYPPYEACFYPGISAKIDGKIDALSKPVYHGWKITYHASRSDRMLTELLGEMLAESEALPAEDSDLAECIPVAIPASCRVEALKIPLVNLFVPPGWSKKRPWWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIZ9</accession>
    <name>A0A2S5BIZ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIZ9"/>
    <dbReference type="STRING" id="741276.A0A2S5BIZ9"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="336" mass="37362" checksum="EAD400892BF7D2A7" modified="2018-07-18" version="1">MTALACSLCERRDGYTFAYKVLGRHQQATPLVLVHGLSAVGLVDWEPLASALAKTRPVLIFDNRGIGSSKIPKERETEKYGVKEMAADVIALVKHVGWREINLLGFSMGGMIAQQVLVTPHLPFQIRHLVLAATSAKPAHSDLLQAIPQPGPGPMSYEDRIKLVTPFIHVGYDPAFIKDPKNKELIDRRIRESVDAKRPSRTVREWPVYWTHSDLLTLPSLCPTENQLGVFILKSAALAQIAGYDVRKLLPAVPSTLPVLILHGTADRSVYYSEAKYIQRGLKHAQLVSFDGIGHTWYDYYTLEYWTTLLTRFLDDAGDVSALPPPPARSAYKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ55</accession>
    <name>A0A2S5BJ55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ55"/>
    <dbReference type="OrthoDB" id="2530209at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="773" mass="83116" checksum="753EEB6B84957FAC" modified="2018-07-18" version="1">MQSPSRLSEQDDLLDAFGTLESFAPSPPPKSPPSFPLQQQEQELFQIAEEPEEDQGPDEPEQDGFADLDAVFLADQPTRSSAAAQGNLVDFFGAEEAFDEGSNRTVGQRPRPSTIGRILFPAPSGGAAIGKSRLLRASLPVQSAANRDGAVPAPRRAKRLSLPVSASSTQSGAPVDNSVTPEPALLTLPLARQLQGQKARARELEEQQIAQAAVQQATAARVKELEEALEKARLEQEGWQAEAQQLAARLEASSNGASGTVPTAPTTPSGTRSTESAASDARLADLERSFALETSKRKRGKELQSKLRCELVNRRWKEKWEVELLEREERQLEIRIVELEARLVLEEYEREMEKLERAEAEDNLATQVRQVSALTASRQVLLSSFRTSEQTIASLRIELSTTRIDLDAAAGVADERVRELEAEVEQLEETKRELASVKKDVQRLEKGEKKGEAERNKDLEKERAKREKLEGEVKALKAQLKTAEAAAKVAKAAAAPLSRSSSTIKATPAHLTDSESEQATAPLPTTATPSEHNAVDESEPDVSAQSELDDDVAVAAEKEAREPAQSKSRNKPVPKPVKGVKVKAAKATKVLPDIEEPADGAVSEEEALPTPKKATSAPAHKKRKADVLGDKSTNARGSARGDDLPANDGPGLKIKKAKKTGTASSKVSALALALGGGDDDSDDDGVPSKSKKAKKSKHRGADAAADDDLPKKATKKRTLLGPRKKFDWTSETADINSMIPMDLSPIKKQPAKKTGSILGASFLSGPAGKASFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ84</accession>
    <name>A0A2S5BJ84_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ84"/>
    <dbReference type="OrthoDB" id="3352285at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="38974" checksum="2F28C861E0898E4D" modified="2018-07-18" version="1">MFPLRQRPPPDAPPPAYSLQRFLPLRTRRTNLRTVVLVIAFFSAIWSIVVGAAYLRARNRDALPSKVQLIYLVLAILYFVCTAIELFGLAAAYRASIKLVRLYFWSSALAAAIVSTAEILRTITHFAYKDDIIKSCVASYASDVNSGVYSSSEISSYCKDSWSNSSYIDIALLIFTFLVSFFFASVAASYLHQLKNPGTLRTQVAQAASSQYAYPLRPFDSHLGGGAGPVPPYPEGQQPLPSYDNPYGVSASEEKFSAPPPSNGQYAPPPGPPPSHAAGAHENPFADQVEHVGSPALVRRPGETADEFEQRQHEHDLQQQERQMRPVYGSPDADRDAFASTETVTLEPRSRGNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZD0</accession>
    <name>A0A2S5AZD0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_7100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000170">
        <property type="protein sequence ID" value="POY69902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZD0"/>
    <dbReference type="STRING" id="741276.A0A2S5AZD0"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY69902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="148" mass="16036" checksum="EDAB9C7D9E5F0855" modified="2018-07-18" version="1">MATEGQQTEASQPQQLAPETIEYARQFFDAARRGDVAFMQAPLEAGLPANLTNSRGDTLIMLAAYHGHPEAVKLLLKHGADPNRLNDRGQSPLSGAVYKNEGEVVEALLAGGANPFIGEPNAWVAAKMFGQKEWEERFSKFEPPANSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZE8</accession>
    <name>A0A2S5AZE8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_7084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000167">
        <property type="protein sequence ID" value="POY69917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZE8"/>
    <dbReference type="STRING" id="741276.A0A2S5AZE8"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY69917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="195" mass="22799" checksum="8673FE7770D251A8" modified="2018-07-18" version="1" fragment="single">MGAYKYLSELHKRKQSDVLRFLLRVRCWEYRQLNVIHRASRPSRPDKARRLGYKASRGFLSGRWRLGGFGSMLAHDLQAKQGFVVYRVRVRRGNRKRPVPKGATYGKPTNQGVNQLKFQRSLRSTAEERVARRCGNLRVLNSYWINQDGVYKYFEVILVDPSHKAIRRDARINWICGVNHKRRESRGLTSAGKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZM5</accession>
    <name>A0A2S5AZM5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_7030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5AZM5"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000099">
        <property type="entry name" value="Sensory box sensor histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="855"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="928"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="1133"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1378"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="625"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="836"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1529"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="646"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1538"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY69986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1548" mass="163903" checksum="1BB83ABD645A93E7" modified="2018-07-18" version="1">MASTAAGAGGIAQVALHALALPHFIFDADARLVSLNRAATKLVPSAQLTKTRAEDLFRRAGPGRLQATYEDEERSPGGRAGTHSGGDGGAGLLQSLARGPAIWGQNSVVDFASSSAAPRPVEVAVSQFVPIGSTKPAGRDHMYSVLLVRPAGDLAAATPVAPKARSRQASVETLVGHADFAVPALRRAESDPVSDSTPTLGSSPFVDPFNKSAIARRRASEASQSPASAGLLKTRRSGHLDSATLIPHDPAHLTIAERRQSSSSTASYATATPDAPHIAASAMAAANSVVDSPTSTKGSSSAGGRTSNGSAYSSASTAATTPPSSRSASSGRSDPPPPVPEVPKEYRGVGVSVSSAGIQLGHSVEAYTGATSPLRSAGPATTDWSTNAGGLKLAPNEGGPRPTYNPRPTAVQRGNSSLQVHAVEDQSASMFAPASPPTTAGAPPSPRPNALPPLPVQKPRATPDTSELLRFAALANLPHTGVIVSDPDLASGYANALARELLMGVPSTDGISKVDDSGTNDARSAFEWWENGCWDSAEEPWSSASTGTQGTNSSSSQPFFTPATETRDPLDAREIIKAGEANTVERGTGTAGSSLKISKPSGQSRHKMNISGILARSLVSEEKRKAALGKVPASDPTAAPPPPSATRPALADLSKSALPSGLTSPASSSSRSSSNYSRQTPQFVSAGGASSRKSYRVFDASFSQRTIDPFGPLLEMVARRGEIPPAAVSSEEESDDDDDFVSSGRVTNGMLVGVEIEVWTSGEAEDADAGAATAHNASALKAASFVTANPFANRKKRVRRRVVEVTAAPLRVPLPDGTMQHLGGILLLRDRTDERKRWELSKPSSNRKRGKQGGGASYHKQILDNLPQMVWTTSPLGSHTYYNQTWYTYTGLEPEESLGVGWQSPFHPDDMESCLKAWSHSLETGDPYSVEYRCRRFDGEWRWFLGRALPFRDSDGAIKGWSGTCTDFEDLYRTREQLRGLLQQNAAVVQGAGCLLIATDCDGRITFFEGAQKEAVLADARFGGVIEGRFLSELDSSPELVKALTEVIGGDAPSAEVAWSRNERSFRCSLTPLTEARNDRSVTVGCIVVAHDITDLVSTQIRLKQSRDKATQLEAAEVAAKEASRLKSEFLALTSHELRTPIAHMLGLSELLLSEELTESQRALVTQLLRSGDVLLELVGQVLDMGKVEAGKLELEIRPFCLNELSTDVGLYAMAAKKKGLAFEEDFDKFGTRVLGDMPRIRQVMVNLLGNAIKFTTHGKITLRIKKADEDDSSVLVRWQVQDTGIGISKEAVPALFQPFHQADVSTSRRFGGTGLGLSISKKLIELMGGTINLESEYGVGTTMTVQVRLNKVAPNATSPSTAAAPHFMDVLKKENLHILVVDDNELNRSICTRLLSKAGFLVDSVANGFEALEALERQKYDLALMDNQMEGLDGLQTTIRIRQSNNPQVSQVKIIALTASALKGDRDAFLASGADGYLSKPVRAAVLESTILRTLSPRGSASAAAAVASLGLAGTALVGTPPTESAIKTGFDFDGTGAREDRSASYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B067</accession>
    <name>A0A2S5B067_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B067"/>
    <dbReference type="STRING" id="741276.A0A2S5B067"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF162">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="265" mass="28571" checksum="555494139B755AA3" modified="2018-07-18" version="1">MQNSPAHATKHISELDYLLPDRSTRVLVHQDDSTANSTGRTVWLGAQVLSVYLHDLLSSKSSPAAQQRPRAIDLGSGTGLVALSLASMGYDALATDVDMIVQGVLHRNVEANAAKLSGRIKAETLDWCTFDRATWSASTSANVDSVDLLTTADTVYDPSLSAPLLQTLHGLSLLFAKPAPPPVYLALEARDPALISAFFALAASEPFGFKCSRVDPDRIRKLVEAKDGTLGWQDESDWEGVEVWKMVLSKKEVARAKAERKAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0D5</accession>
    <name>A0A2S5B0D5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phospholipase A-2-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0D5"/>
    <dbReference type="STRING" id="741276.A0A2S5B0D5"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="242"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="433"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="577"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="88453" checksum="08A2DE42705C31A7" modified="2018-07-18" version="1">MATEGAKPRYKLSSTLAGHGSDVRALVGCPRPLLAASTSAASTASPYSAERPFLFSSSRDGTARGWICRGGGAGQDGGAPGGGWVEGPVLGGSEGAQGGHEGFVNAVEWLQPSSEAEGGYLLTAGQDKLIHAWPLPEPTKLATAEQSAAAIPSPSPSHTLIGHGANVCALNVSSDGKRIVSGSWDKTAKVWKNWQLEYTLEGHEQSVWAVLALDGPKDDLVLTGAADNLIRLFKRDKLVKTFKGHTQAVRALAKLDTSAGGGVGEDWFASGSNDGTIRLWSLLSGECVHTLFGHDSFVYSLATIPDSLGGGLVSGGEDRTVRVWRAADGECEQTITVPAVSVWCVAVMSNGDIAAGASDGLVRLYTRSKERVASAQELSSYEEQVAKTALNSSQIGDLKKSDLPGIEALEQPGKKEGDIKLVKTEGGSVEAYQWSTGSRSWQKVGEVTDAVGSSRKQLYQGQEWDYVFDVDLGGGAPMLKLPYNANENSFAAAQRFLYANELPLSYIDQIADFIEQNAGGVKVGGSGYLDPFTGASSYRSQPMPTQGASSNAGFAGDPFTGGGRTSTPSRPTPRAGSVLPHQSFLTFTQANLPALRNKLQQLSDQLAASPDTAALALSSADFEALDRLITFLLVALANPGSASAPPPESDTAVVDKLLATWPPAQRFPALDLARLLSLSAPTPGSFPVVLATSTDPTESETNSMLALRALANVFIPMIGKATMQGEAVDVLSSLRKRGASRGLNKNGKVAMASVLLNFSVLATQKKLDGKASRDLAELSAELLQDTDGEVVYRAMMALGNVLASFDTAAALTAADTDRFKTVAKSAAQRSTEQRIKLLAGEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0H4</accession>
    <name>A0A2S5B0H4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0H4"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="336" mass="34542" checksum="6BE43D65EEDB19BC" modified="2018-07-18" version="1">MAGMYAIGTAFLPPPLPSTGTLPPASSSTATSQAATANGGAGGGIASLSNAPTGTLGTSLEGLRTLVNKRKTAWTYLKNAADGRVYWFNTILLTGDDLRIAFPNDKMRNRTTRFAVLGMSLSSVLDIAPAHDFLRGLLALTQDFDAMPEERFGGKNQQPRSLFKVGSKSRRGAGGITGPTNGNGVGGGAGDFGFSLGGDGGDGSMLFMPNIPFELDYLQVLITTCEILIEIYTKIGSYLGPPGSSSTSASSNGLFPQPPHPGSGGGAAANHRGLGMSGGGGLGLSPALIDMVHKIDGRLKKLVSLLSKEIDTLARAAIKAELNTLGAVDFGLDPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0V6</accession>
    <name>A0A2S5B0V6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000117">
        <property type="protein sequence ID" value="POY70418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0V6"/>
    <dbReference type="OrthoDB" id="2525846at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="283" mass="30332" checksum="BD45BBBCD7200D37" modified="2018-07-18" version="1">MDNVFANLQGAPAPAKRSRDQVEGDPSPGKRIKTNMLVEEERAREQQAALAAPPPSPTPHWSTALAKQQQRALEMMHSEAMDEEDIDMGGAEDHLPSNPEHPWNSAGGQRMMHQLSTTSLSGTSSSNDSSMPNTPLDLPFNEQWDPSSSSAATPKPIQPGYPSSNNPTSFTNLNGATVVFSTSPPLSVYPPPPVAMSTPAQHNPLYATAGFPMHGWSASTSGVLRMTGPSMGADAMADESLPQQSSSAPEVIRELNMPTYGWDVPRQSNSSTWAPISSESRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B120</accession>
    <name>A0A2S5B120_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B120"/>
    <dbReference type="OrthoDB" id="2520927at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="73" mass="8022" checksum="2056C32438656D42" modified="2018-07-18" version="1">MSTRGTMGGPTEAPRRAASTMRGTLVSFFAVLGLALPTFIYFKRQNDQKAREMYAQTRIKSGAMSQMSSGEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1D8</accession>
    <name>A0A2S5B1D8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1D8"/>
    <dbReference type="STRING" id="741276.A0A2S5B1D8"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="322" mass="35290" checksum="96DA0BED304F3407" modified="2018-07-18" version="1">MPRPDATVTRSNPATASVTRPHRVCEPCFKRKVLCDLVRPTCGACTRYSRNTPRHRCSYGAHTVPSEPRQLTASPFNPDDFTLPRTRSGAKVLQEIQEGTPEPVEPSPSPEVPEMETDEPARLVEQMAQTSLDSETGERRFELPLPPVFRPMHFPSFPRDLPDVHSPSASPRPPQIDAHSPLYIPTAPAFDAPETPPHQYYPRQGQLAWAPPRSPPGFASVAATHEPYLPMDAFPGEPSAPFTPLPPGPWRTFPSPSPEAAVPSLPSSPEAAHASSLWYSSTSVNPHHVSPSPAPLDIPQMARYGPNSGHAMGWQFYPSSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1G9</accession>
    <name>A0A2S5B1G9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1G9"/>
    <dbReference type="STRING" id="741276.A0A2S5B1G9"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="269" mass="28899" checksum="25CB0F2E618737DA" modified="2018-07-18" version="1">MPVELTVKAILFDMDGTLVDSTPAVEKTMGDWCHEQGIEPSEFFQHSHGVRTQDNLKRFQRVPVPGSSLSPEELTDSVNRLEALIAENGRKMHEAGGKGIERLPGARELLDALKKGGARWGICTSATRIYASSALKTGEIGSAPPDLPFLITADDVTHGKPHPEPYLKGMEEARKLSGASFDPSEVLVVEDAPSGLKAGTDAGCKTLGVGTGQPLERFKTFEATVKALDLTRQSVSTFANALFTHSVEVVSASADSVTLRIKTLEEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1N7</accession>
    <name>A0A2S5B1N7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000098">
        <property type="protein sequence ID" value="POY70697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B1N7"/>
    <dbReference type="OrthoDB" id="2529979at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="143"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1389"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1395"/>
            <end position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1478" mass="156897" checksum="E222BFF4B1690972" modified="2018-07-18" version="1">MPSFFSRFSTSKLKEATNSKSKHASSSSRPAASSPSTSLLPLELPSSSLLADTSRATPHFLSTPDRHPSYDGIAPALYSPDHDDADGSDLRSLKSAESARWVAVDADSTPRTIRTAATPDRARRVGFPGIGVEDPERVKREQARLEKARLSVEDATLLIEECGDVIRARGLTTLGLFRPFRASESAAQFRKLALLFLDYIAEFDSQDSALRLDNSASPTRGTEASKSVLLHAYRQELRFANVHDCVAVLKWGLRHLDFGRMTFSSLRVPSLEWYSSFVSRSSSSSPQHPYDAFSTLLLPSLPLASQQLLLAVLRTIQPVVAHAQQNAMPAPRLCYLLGAYVFGLAAGPSTRARGGSSSGSSPSWDDFAHQWSAAGRALEGCLKAYLREQSDLPPRLQELIDDYPAWVADSDRSAAADATRTRRRTIRALKVEIESLGEWETAGTVRSNSQATGLGIEGESKRPARQRPVEVLMAAIGAAAPVGEQGPAESRAWKTLVNHLSSAAVANADSLRLSVLDEETVRVLGLLGLDKPTTRDASTASPGRPVEGSPHRRTRSSVEPADFSPVRPQRNSFLSPSPSMPTISPRVRLRSSPSWQDFSTQGFAQSSLNLSSDLYDPSKNRSPPPPRSIEVQRPTTRMTGLSLVDVDEDLVSVWLDSLAESSTTMSPVAAWPCVLLTPLSPAARSEDVLQKASISTLLIVETLLPRTTSQAAVNSPPRPPLLQATSSRPSEVNRRASFLGVRRGRKSEGATSMQSSPPSSPSKNWRRRASALFAPPLSSSRQQSADDVPTLRGSGLAGRDPPTLTPPLLEHAERPVPARAASGPPVDVFGTAIPLPATPPPPRSEALTAPPMDRVHTAELEGYIVEEPAVPPRTGAIALPAVEDNAIAAGGVAASAAFMVPETQEPVDDDALQISPATVAPVAASAQAGEHDALKANGPIVADHTVVKDPASSDQHEPVEDLATSGRQLEQVETGAKAPSVETEPDAASVLPHDEHQSADLSEPNQRPTDAAEPASTIVGDRVDEVHVAFEADTGGANGVQPVLEETTAPVTPRRDTRPIETALEPSSLEKTSSPKEDQPTVTAAVLEESLSSPVSPSLPPAASPPARSPRHPARGPSSPIRRSVTPTSHSDMHKRSASSMDEEVKQLRKVEEDDKRRNMPEPRTPKTVSNVKARVREIEEEAGGVIASPDGRGPASASPVRTPNRAQRPITPRRSSQRMRSTQSSTSLREMPSLAAAIVSGSPAALGKPVDLASDSPQPETPSTPEAAASESKWLVHNDESSGTIETVAPVHGVFESKASPKAPADQRVASDMISTPAQESEYLSVKVPTVLERLPSPLPTPTPVGVAVNGADDGLTGGPVTLGSGLASESAARPAAHVLLGDEVETAAQSEAVSREQEPKADRAVTTQSLQPLPLPATPTRTRHGGNPEDVASHVADTSAGALAVSTPKPGHADHAESARTTYFTSRHPGSPLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1S7</accession>
    <name>A0A2S5B1S7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1S7"/>
    <dbReference type="STRING" id="741276.A0A2S5B1S7"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13759" checksum="48A8140C748B6389" modified="2018-07-18" version="1">MSSGKSKALTEQEIGVQVRQRQSELQSLVQKLTDLERDAEEHALVLETLQEASKTEPDRKCFRLVGGVLVERTVKDVAPQLESQFEQIKSLLETLTSQYKTKEASFAQWQRDNNVVIRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2H6</accession>
    <name>A0A2S5B2H6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000093">
        <property type="protein sequence ID" value="POY70965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2H6"/>
    <dbReference type="STRING" id="741276.A0A2S5B2H6"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="80" mass="8735" checksum="E94CD9A0C6E77A18" modified="2018-07-18" version="1">MSQTFVRGAKLGQKVRVESELVNMGKTLAYTRVEILSADTGKLLAYGSHTKYIADALKSDKNVKFSEDGESITEGVEPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2S8</accession>
    <name>A0A2S5B2S8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosducin thioredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2S8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2S8"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36295" checksum="7EF11E878F82EE30" modified="2018-07-18" version="1">MSAIDYEADTEFNDALRRHGIIPPKEKKEGSRSPSPPPRPASPTLSELDLEDLDIDRDDNARRDDIERVLEERKRREKEQLGKRKFGRVYNIGKVDYKREVTEASNEELPGEPEGWGTGVVCVLFKDAVPESKKLMPIINELASLYPSTKFVSIVSDHCIENYPDKNVPTMIIYRKGQMMGQVVGLGAMNGMQATLRDVERVLFAFRGIDFHNKVGYDTSAASAQFASRSDAAAPLSKLGSATVGEGRPTRPESDDDQDQDSDASGGDGQTFVGGGKRSGIRRGTKMTKKKGDDSDSDFDLCPVQATLRSLPVQVAIGMTAQLTPLTAAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Y0</accession>
    <name>A0A2S5B2Y0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Y0"/>
    <dbReference type="OrthoDB" id="2520628at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37127" checksum="501645EC03DAE0E9" modified="2018-07-18" version="1">MVSTAAWELTLAPTLTRIGSTHNWLNSTLVYPSFPFTIFAVIHAVRVACVYRGIARAGGYDRQLGDLQAAIVPLVLILGGSTISSVLLGLVPGWIISPVPVATYGRVSAPLIPLLAAKSGLVSFLLSLPALPRETLFCLVDGFSRIMGMATLGVDVVRAHPNPAVRSSAWAMILTAFISGGGGGMIVPMFRMFGPEWGFTSTPAFVKEGLSIDVWSAAFIGYVYATLIDAHPFFRKPVAYLLGRLPMLHPYVHLPKTYFTSVKPSMLLQPAEAKTFCSLLLALMLFTSRIVIPALSRSSAKASNAAAAQKRRVQDQAQKAVKSASTAVEDKVPTEASGIRQRQKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B312</accession>
    <name>A0A2S5B312_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B312"/>
    <dbReference type="STRING" id="741276.A0A2S5B312"/>
    <dbReference type="OrthoDB" id="2804493at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="635"/>
        </location>
    </feature>
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            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
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            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
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            <end position="283"/>
        </location>
    </feature>
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            <begin position="306"/>
            <end position="315"/>
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            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
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        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
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            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
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            <begin position="502"/>
            <end position="515"/>
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            <begin position="550"/>
            <end position="564"/>
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        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="635" mass="65960" checksum="92597BAA5DF1C7D7" modified="2018-07-18" version="1">MSLVEPNPQTGSERRKQRGLRGFFQKYFTSYPHTPASSAPASRTSPASSTRASTRGAPGLGLASGSPSHSPTASRPVTPLRSHHPPSGVTVADRPITQPRPERRRRRRRRTQSPVGLPIYSERPTEDEMSLFKSHDDAFGPTRIVVGIDEEDDEEGVEEISDDEDGDGRSDEDQEDLGGGGAGAQDEENEGEGADSFFAMPPRQSFETTHGMPNYSRRRSSGTAAAGNEDAGARPTIRGRPRAVSEPLGHQLTQQTTRSSLARSAATNNSNSPYLHGSSSPFASRSGLIELPPRPPSPPQAELAVSVSSTTSRFSFRPRHRPSRSSPVIPPSASSPVLPSSSSTSSFLGSGRPRSSTLQKLMSSTAGTSSASLAPPTAFETNSVGAGGGKSPYGSLGSRASSSQVSLGRRSISAPLANSFVHSSFVFPKTGPTPEQVAFISSRQAIGAYGYGAGASPPPPLSNSPPPNGSALPPPPEGFGTTDGHASSDGLIAPVPVRGRARSGSSASQMSAGASPLSREVRADAPPPVLATAVLDSYSTGACRSSGAPGPEPATPLPVLPPLSPLEGFSDLTLAFENRVEAFERVADTEDPTGGESAPRRRPPDITTSAPTPTASAAPSPRLPSRTSFAAEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B362</accession>
    <name>A0A2S5B362_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B362"/>
    <dbReference type="OrthoDB" id="2501121at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="284"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="449" mass="48034" checksum="3CA51AB88078A843" modified="2018-07-18" version="1">MATARGESPIDRRSSSSAACLLQPASFLSIRHARMSSEPSSQPQGVQPHDALPPMPPQAIPPPSAPDLSALLRGALPPQPGLPPHGNRHPVVKSAKPTSEQVDERCWTFTKQTNAKRALGREPQTTMYCYLNLRNVIADLVPVPGAPNAFLARDAPPGSPAAAELELKVKERLASKRDPQIGPGGNATEQKVPEYHWPWLDGRYLYIATGRSNIARHMTEMGGAAAADSEAPGAAAPPAPALVKPTKESPVAAATATTPGLDQSKPSSPRPRRRSLPPTLDQGHLGAWDMLKRIEDRVEKAEADRMKPGKREEAMMRKALGFEPEDSERLVSLSEAYSSGLQRLHAHVVRIYSPGLKNLARLPETFTDGTQAQMLDTVTTRLTDGSAFRLVGRMRDSLGNVYTQLEERRKRRGDSGEGGPFGGTQPPIPGGPPAPPAAPPAGFPPAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B372</accession>
    <name>A0A2S5B372_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rdx family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28625" checksum="A024BD2006CDE231" modified="2018-07-18" version="1">MADQHCLDCTPSEPSNSSPSQATPSTLPDRTSPSTPTDPLLDPASFEPPDLGSAQGEAPRVLIEFCDRCRWLHRATWTQTELFLTFPPASLDQTDDGKPAPSPGLKSISLVPRNRPETGGRFRVWLLLSGDQDHSEGGPYAASAKGKERWRGWQLVWDRKIEGRFPEMKELKQRIRNLIAPQQNLGHSDKPVSRPSADHQGAPSVPTPPSNTSAERHSSVPPRIAADNETSEKPGIDLAGLADQPLQPLTAADFEPKYRCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3F0</accession>
    <name>A0A2S5B3F0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3F0"/>
    <dbReference type="STRING" id="741276.A0A2S5B3F0"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="67"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="465" mass="50602" checksum="40851736B82A1CDD" modified="2018-07-18" version="1">MAMNALANVAEKVRDAVPTTITNHLSNPAQQKEEFADPSGEKMKALVWDGPMKVKVEESLKPKIVDPKDIILKVTGTTVCGSDMHLLAGAIIELQKHDILGHETMGIVESVGPEVKHIKVGDRLVSGFNIACGECFMCQKKLSSACVKANASSTMQSMYGNRTCGMLGYSHFTGGFAGGQAEYVRIPYGEANCIKIPDGVYDEDALYLSDSLVTSFHQVEDTGVEEGDVVGIWGAGVIGLLCGVWSAMRGASHLIAIDNAQWRLDDFETKIKRDYHNIRIDTINFDEVKNVTAKVQELTQGGTNGLPETRPAGLDVALECAAGEYAKGWGHKIELAMGLETDSSEILNEMITSTINFGRVGVTGVYAGFTNHFNIGSLMQRGIRFIGNGQAPTHKYMQRILDDYIVTGKIKPRELFVSHRVPIEDIAKVYYSMREHDPKDKILKPFVTTAASAPPAPGAPPLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3H5</accession>
    <name>A0A2S5B3H5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B3H5"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1326" mass="145079" checksum="656122FB4BDB37C7" modified="2018-07-18" version="1">MALPLHTGEPKPRSRRPSPLRLRSSNTSPQLTVHSDGSAGLSPTSPIFYSPTLQVSPASATASHFSQLPPSPPLAGGEWTKQHPEYAAATTFYPTPPASESGRLGGRSPGSDTRLDMSTSLTTTSTSMQRQSSHSSSILLGEDLNHPRSPSKRRPSLILTSAETEEPQGLAIGIDMGDVSMPVPSPMMRRSFSAGSTSPMNSPVSSYFSTSPANTPPLGAMPSPLLSADSPVFGSSVGMDRSASSSPRLASITGFASGLVRRASSNNLKTDLPTAIKSPLLPPSPTLPGPPLSPSLGGFSGLTSARGASFASAARDKEREKERESRERELKKKNERYHSRMFSWAARPDDPLFAKKAQGAKLARIGKGSAPVTHSRPRWTRRIVFLALLAALVYTLSGLGRFFFGRDGSGHPSTRVTTRSWLNSPAHWWRRSEAEPHGPSASARDEQPATLVVPSAYARAPPQRNEHDQKEPQEHVHASAFAARDARKPHNVHVAAPQVEFVDHSAKPPPITHSDAHERDTLVMYRILGNDLPPRHSPGQTLRNLRFLLEHESDFSVLPPLGPHGVHHASMYGSGSQAKRAHSRLGGLRVDKYYVLNRIADPELTSAIIGLLHLFSVPDANILTIPFDWNEYQKRDFRWDGGVDNAHGWDIGDGHAAHAHGHQWSKADGHVQIPSDLAKLLEEADGDEARGESHETAVEKLRRSDVLGRLRAIDFTYHEKNLYAMNNNGGRNFALHHGRSLPRARWILPLDGNSFFTPAAMYSIVRTLSIAGEGPAASRYLVMPMARLLDNADVLRNNSISLVPLGKEEGASAIADAEILHRPAIAPDTPEEPQIGFRYDSTESFQEAMRYGRRSKLELLWRLGAIPYSRGLDKRTLPWEVIDRAHITVDSWGSIPGIEGGATRDSIIHAPHGEVEDSHVPNPEHGALAYVKGGWVYRLFSGSRSQEVHSPDAATLRNTNRIRGIVAFLENLDELVARGEHGCFGEENPFNCGFQPDRLWNFDLFDLERIRQKYKLKRRDAVLKVEAYERLVQPTLNTFLHILADPIAFEDLHAQKAASGATFLAVAGYLTGNATYSNAGASVIAQRFVRRVPLYYRRSEASAHSQPPNSGTSSDDLSDMHGDVRGYAFPPFPKDSSESHTWSAELASKLAMPGAPPLPFDPATFDPILLLDGIRLLNHASGPQLEAPAQVSRAALVPLLNAHLSYLLFSEEAIEFSRHPASREAGAHYDAKVAALGAYLDDAQLVGRVANRARLRLPHFHRAEGLLDPSREVRDIHYRLLHGLANTRLRPYNMIPDPVDATDAELRQSYVALAYGDNTPLAVLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3J4</accession>
    <name>A0A2S5B3J4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3J4"/>
    <dbReference type="OrthoDB" id="2538259at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="461" mass="47915" checksum="03B3468DCF84CA51" modified="2018-07-18" version="1">MDHSFGSSTSVLDTPTNRHGGLSSSVLNRNQLASSIAPSGPVSVQPLSFKPQSLANTGSQGAGVVKSVRFSPAQPNYSNGSPHGSASPAFSAAPPSRLQSFATPPRSYGSPSLLRTATGNASAGTSTPPRQQQQQQQLSQHSQPQQRQPSQQAASGQSSTPQGSTVHQHPAVEQFLSHLPHLATPQSVQSAISKSSSAVHEGIQHAGAEAKKKLEVMPIGRGEAQNRLKVNAGFLVAWWVSYRSNPYRTATAHLAAAVPQIDTPLHIGETLLLLVLCWNILDALRLLNNLSSLPPSATSAPLLTSSPALKRSPAVPSLGSPARSSPKTRATPSMFGSPAAGHAGSPLRPNGAPSSPFRASVLRGSPHPPTPQTPTSALLRGSPSLSVTRSAATSAVSSRSGSEATMPAPSDEIKGALLAYEARHGEQFGSPVRDEPIGGRSPATARVKVESREDVERLLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3R9</accession>
    <name>A0A2S5B3R9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 49 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5746</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3R9"/>
    <dbReference type="STRING" id="741276.A0A2S5B3R9"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="64940" checksum="67BC1183F5517B9A" modified="2018-07-18" version="1">MNKQGAVAPPAVATTAGTLPTATSQPTRLRRLARFGASLYLLSAIVYTAYHLVVVPAASHIAGAQLQSDPGNAPGSLVNQVVQAGLASANPSRAATAAVVSGEPTKKTTSKNRHAALETAGVRAADIRNEDSSDPVWAAAESADRKKKNKAAAGGIAAYTPPEHLVDGRELVRTRVHGFDGVDWDADQVVWHHPATELAHSGPRAHGETLKLYGNNPRALKTTSEDELLSISFGSSLQPSKVIPYYYRATEPDRDDFNKEDITITTLVTSNRFTVFERLVERYQGPVSATVHLSQGRSQDDMLRALDKLYTESPVMRKFVDVHLVYDAFDRQFNMWRNVAKFFARTEYIMMLDVDFWLCTDFRSRLLNSPEIMQRLRGGLAAFVVPAFEFHKQSDGVDPSTFPSTKEDLVQLVQADKIGMFHKSWAPGHGSTNYTRYYDAAPGEVYRVQGYTHSYEPYVIYKKEGSPWCDERFIGYGGNKAACLFELYLSGVSFYVLPDDFLIHQSHAYAEKARKHERKYNRKLYTDFREELCFRYLNAFLDQIESPRAKNLAIECKKIKGFSTTAARFITAAGGTLGPPTQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3W1</accession>
    <name>A0A2S5B3W1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_5693</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3W1"/>
    <dbReference type="STRING" id="741276.A0A2S5B3W1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="643"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY71381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="699" mass="77304" checksum="9DDC59E1C6913711" modified="2018-07-18" version="1">MVRTVSTEAREISQGPVPAFEQPLRVKRQRTRPLPTAADLWVDHLPGLPSDARLSLFAGNIPATSPTAVPSDSDSDAHLYFLLARNKHIPKRERLVIWLNGGPGCSSFDGALIELGPVRVNDDGTLRVVEGTAWNEYANVLFLDQPAGTGYSYVTKNDNVHELDGAAGHVVNFLANFYKIFPEFATMDVRTSISVASASGTGTDWPHKFQTYIAGESYAGQYIPYIADAIEKTTSIRTPVKGLLIGAGWISPREQYPAYLTYLEMNNLVDRKSAAYRNLKGTVDRCKQKLSSLEQNNGGKGMVLVNECEQILGAMSAATSKDGKCLNSYDTREYIPCGQEWPSDIPRITQYLRRPDVIKALHAEEGTRGKEWVQCSGVVGSHFWTPKSVPAVYLLPQLLAKMPILLFNGDKDLMCAGIGVEKMIESLEWNGDTGFNGTESLDWFVDGESAGRWTTARNLTYVEVFDSSHMVPMDKPAASHDMLLRFLQVDTMHSAGAAASIPSRIGPEVETVLGATHPNGTSLVDLLNLASGGAENENGAESDGFGGGIVIGTVGDDIEHERKYGPRKTAALVGLLVLLGAAVWAVLRFRKRQRRERYRRIKGKGRATRHLDEETDLSEPESRLRSRDPIPSIAVFDVGEYKEQEDRSEYEEERFGHDRRGVRFSEDQADRAGDIGRAADDANPFREDQQRQYERSFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B467</accession>
    <name>A0A2S5B467_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="3">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_5419</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000080">
        <property type="protein sequence ID" value="POY71556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B467"/>
    <dbReference type="STRING" id="741276.A0A2S5B467"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
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    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
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        <property type="entry name" value="SETD2/Set2_SET"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 20" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="19">
        <location>
            <begin position="231"/>
            <end position="286"/>
        </location>
    </feature>
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        <location>
            <begin position="288"/>
            <end position="405"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="655"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="835"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="890" mass="98562" checksum="C4B97A6D4143E19A" modified="2018-07-18" version="1">MSLDPFALPPSSNSQAEATRTAADLPPPPPDRTDSKPEDLATFTAAASTSSHSHFEHASASNGHAHAGENGTTDSNGLTAADVVDEDRKPDLPPPFPFASTSKAVLDAPEPTSADGPLSPRGGASRRSASAAASGSRNGDHGPGSRVGSVKSGSSTPKLEGIGDDDDVKPITTTTTTTPRAKGKKKKVEESVPQFIGDLPLAEEEAARTFEELEFSTYFSKSLGDVKYYEAEEAQCDCSYNPNWPLDEQACGVHSNCMNRLMQMECLAGDCRCGRHCQNQRFQRRQYAPIEIVKTEKKGFGVRAGADIPADAFVYEYVGEVIGPTPFQRKMKEYANEGIKHFYFMALDKDVFIDATKRGGKGRFLNHSCNPNCYVAKWTVGKKMRMGIFTKRDIKKDEELTFNYNVDRYGHVAQECYCGEAICEGYIGGKTQTDLGGMDDLYIDALGIAEEVAALGLKGTKKKKGKKLDEDFTPTLHPIQPDEVPKVSAAIRQALQTRRILEKLLTRVHMTTDEDVQRDLLRLHGLNLMNNILREYEKDIHIITLDLEILGRWKLQTRNKIESSKIEESVQKCLALEDDKVKTLANELLQSWADLQLGYRIPKALLDAEEASDRKRVSDFDLHQLSKRARLDDSDSEVKPQRPELQFAGNTTEAIRLPEGWDAHYDRIRDATLFINIYTGAQQWDQPTRPARKPEPVAPRYAAPIDANEIIAQAERAAQAAAEAEAKRIAEEKAAVEAERKEKEEQRKQEKEEKARAQKEKKVMGLFSGVVVATMSKYRKEFEPEAFKKRAREVSEILVEKEKKRPSYATDAYDSLAPEKEAKVRSFVKDWTKKLLERKKTGRSSSSSTPRKKPSSTSAKTDIDQTLSVNGNGAALVGVDTPDSGPSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B482</accession>
    <name>A0A2S5B482_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000083">
        <property type="protein sequence ID" value="POY71521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
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        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="246" mass="26403" checksum="BA083BD9DFAD72AD" modified="2018-07-18" version="1">MTGEHHGHSHAGAPQQMGLPPPGAVMPSGPPPVPDSELTLLPLALDPTPMGPTPVKFALNETIPQGFSAKDLEPVNELARILLTATNPHVVFPPPPQPMPNDRSKKIANAKEAGNVAFKKGQWGDAIKLYTMSADIAASRPVFESNVYARDELALALANRSAAYLGAGDPVSALIDADAVIQLKRPWIKGHFRKGKALVAMARYEEAREAFLLGLQFDPSAEELQGAVSEVEEQIRQRDSQKSIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4F6</accession>
    <name>A0A2S5B4F6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4F6"/>
    <dbReference type="STRING" id="741276.A0A2S5B4F6"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="365"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="873" mass="95312" checksum="77DFA42777216362" modified="2018-07-18" version="1">MSSSRPSRGDDPVLMHPSSALVRPEPYSVRATTTSSHPQLRDLLVHTPEHGNAVTVVCYDSLCTVDCYASRPPEYTPLKFSPSVLAAGMGLIAAGGQSSELALKSASPGSEWCFQHLPSATNASATGVRTLHSGSINNGIFICPSPTSPSTPRLLVSSNDEVIKVFEVEGAPPDYRKAKRRRERVRRDEGFSVVEATWAAERGETACGPAGTTSWARRRSTAESDDDVEEEPSYDPGQACHLIPRSSENIRLNTAVNHCSVSPDGKWLIAVGDTNEVFLYSAPRHDNEQYELAHTFVASSDASFSTDWNSDNRSFAVASQDGFVHVFDIRSLPSCSRPASPTLRGASSSPRKVAELKTTQTGPAGAARKVKFSPGGRTLDGGLMAFTEHRNRVHIVDSRNFETYQVLDVPIVASQPAYRPGDHLTPPPWSSHYLPNTPPPLRPRPQPPPRTFRSLSRPNLSRLPSASFSSLASFDAAGGGSGTCTPRDEKERDELEREMRERTERRARQEDRRLRAAAHEVRRVRNRRLAPPVGVQDEDEDGEAQAGAGDAARNDVMEIEEAGGLDGEDDDLGFDSAREDEDLDDLRLTGPSDSQLRRYRRGADTDPPRHDRDQVADDTLSGLDIEVLPYDDDDFTESDTEPDNYRMIQQPQRPSHIEPGEEAMSASEGERDDSAASSIDTTRPRRFGPRFGERHGGEALPSSRDRSVANRLAADWVRSRDDTTALDVPVRRNYSGAGYTPLARESIGPIRLPAYVSRSRLGMAPGSSSIPQPSAYYSTYVPSNYPSVSVSFAASSLPATSIPLASLFSAPLIGGGTYHATSAFFPLDSTPGDLLGLDWDEWGERVFVATGERVWEWEVDARARRGSAAWGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B507</accession>
    <name>A0A2S5B507_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B507"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053238">
        <property type="entry name" value="RING-H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF627">
        <property type="entry name" value="OS06G0192800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1385"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="741"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="835"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1305"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="162"/>
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        </location>
    </feature>
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        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
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            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
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            <end position="446"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="642"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
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            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="867"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="889"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="934"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="975"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1013"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1054"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1080"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1100"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1121"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1140"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1221"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1254"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1309"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1453" mass="149359" checksum="1299F4B373737B25" modified="2018-07-18" version="1">MTTPPASPSLNGAAATSAPTHRTSSAPPLHSPPPPPSQGTSPNYLGPAWTRNVVRTTTKTKAPYNGASGASASSLSLVPNTTTQDAPYLTHVHRHHGQLTLVAPDNLGARRQPGTVDPPSTRFDAGGGLGLIDADEAADYVPPPFVTPGGQDEDEEVYYSSKGKKLKSKKGAKKKAKEQKARRERAIMSAVANAGKSPGGASPLPSPAEEISQIHLSAPTPPLTGTTPRASPGLSSVTSSAGSRPPMAPRTGSGTSSSLQQQATAAARRTRRPRPAVPAAGVSGGEAGSSSFTSGSSALGESPHRRPLEGPRPQPISIAAAAGASSETLRTPSPGVPAFISAPQPAAGAAPLQQSRAVARARAARNAHAAVKAAGIQARAIQAIQAQAQAQREELPVPPALPSPSPRASLAGQGTSADAAAMSPSPSASGSSRPAASSSLAGSSASNQFQQRPRMRHRPSEPLLVPEAIPPREGAHSAPARRTAADQSVSRGRAAPPSSGSPGSARGPPTALAPSTSTSGPDSLPPPILPPLDLSDPALIDDHLSLGLIDPAMLLMSPPPAYSGRRSLSSTRTARTARPSQVESGGRTSPGGARTSSAASIAGLGLGMEPIRTDNDTMSHPSPRYSSIPPSGSPPPPHSRRASPTPSTSTAATTIRHANARGSSARLSPPPPLTSSSSSGASDAESERGRLSSSESASDEDEDADSFEVASTDPLVLAWEADRSAGVYTLDERIARDLERRRRAAGEETGDEGTAGEESFDSAPGGDPTRNAAEAGQAHLQATEVRSAVPSRVYSSRTEVAAADLAQLRRRISHAEASNNSRGVVRALSVHATRSLRAQGRTARERRGRASEAVDPSTQAGAAPVSRPQQGPGSAPQTETIAEDEEGVSSHQARSAQSAADSGTSLRLNETHTGMGPGGDAQLARTLSLRGHRMLAEAAERRMRAEKEARLKASSAVRAQGTLHEEDGNAEPYDPTAAAGQASSSATTGQATSPSPPPRARPPPPPPPPRSRPAPAERSPTPAFSTNTPSIAWGAAAGASSQPPLRRPASIRRMPPPPPPPPNAAEILAAKRASLRPVTVSPSGASATLSPRLAPPPTPAQQESSAPAASASSAAPAAASGTYSDSRAAQAISGTSSVMAGPSQSTSQSSADPSASPPRRRPLPAPPRMLSEDRIDAFTALRRSRELSPQTPSPDNERTVVGTSVTNDDRPARAGSVEPAHPGPPLPRRPPGRPTPARPTAEAIAVENREETAEATSVSRPTTGTSIVRDATASTELPQLEIPELSMYTDLDLLLARLESGQDIAAAATSGSPEQSTERPQGGENYDDLLVLSDVLGQAVPAGATAAELADTLAVARVECERRRVTKDGKVKSKLSVVGVRCVDCAICLARFKVDQFAVVLPDCLHIFHEHCIRSWFRLSRVCPVCRHEVFEPRNAAVAPEGATSAAETDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B511</accession>
    <name>A0A2S5B511_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5186</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B511"/>
    <dbReference type="STRING" id="741276.A0A2S5B511"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="192"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="396"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="810"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="742"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="853"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="887" mass="99021" checksum="99FE25D4A7A86B3E" modified="2018-07-18" version="1">MASAQDLNGASTSTLQTQTFITALVTGCAVAGAELGIFILLKNRFRQIYSPRAYRVSSEKRVDPLPHSLLGWIPYVIRTPARTILERNGLDAYVFVRFLFLMLEIFFPFWVVTWIILLPVDAVGSRGTHNGLERFTFGNVGESEQPRYAAHLILAWFLTFWVLYLIKREYARFIVLRQDFLMSKEHTRLAQSRTVLVTGVPKEYLNQDAMHRFCSVLPGGAKRVWFARDLKKMPDLFERRAKAASKLESAETKILKLATKRIAKDRKNNSPPPQDQDPEANKAAVMRYVPQKKRPTHKLGKFGLYGEKVDTIEWAREEITKTTEELESERRLLDGDKYPYDSAVFVQFHTQMAAHMFAQCLNHHAPLRMSSRYLEVGVDDVIFSNLNVNPYQQRLRYFISWAATIGLIITWSFPVAFVGAISNVSSLCATVSWLRWLCTLPVPVNGIIQGALPPAALAVLFMLLPIVLRLLARFEGIPLRTGIELSLTTRYFCFMVINGFLIVTLSSGLIAAIPKITQNPSSAVTLLATQLPAASTFFLTYFVTVSFSGAAGALLQIATLVLYYVKLVLLGTTPRSVWNLKSSFQTVAWGTLYPSMTLLTVIGLTYSIIAPLICGFACVAFALFWFAYKVCLTRAEWCCLASNKYLFLLVIDTPPATETGGLHYPKALTHIFVGLYIEQLCLCGLFFLAQNSNGKQSAIPEGALMVVLIVITAIFQIILRSGYKPLITYLPLSVAQRMTDRAPVPYSDSGRDAPVDSITNSPRSFSSQQQGDQKEKDESTFPPPRRSADEHNIPLRAEDSRGAETDRMTADGDEHLDQNAFDHPATYQGYDTIWLPQDPAGLYRDEVEATQAAGVDVSSEGATMSEKGKVDVSRAPPGEEWDPSQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B517</accession>
    <name>A0A2S5B517_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B517"/>
    <dbReference type="STRING" id="741276.A0A2S5B517"/>
    <dbReference type="OrthoDB" id="3184331at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049:SF16">
        <property type="entry name" value="PROTEIN VDLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="86"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="390"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="550" mass="60604" checksum="037E60CAC3755D51" modified="2018-07-18" version="1">MDAHDRDSPLQTPQVGHSDRCFVPVMACRAAVLFQTSYKPGTPVWTREWLEVVALVAVSAVCEMRFRSAYQERERSCERAAAPPREAPDVAYSYKLSPVECDQHGRVYGGELLKLVDVSAGLVAAKHAGGPCLTISVDRVIFLQEIRVGDVISISSAVNRAWGSSMEIGVRVMRQSRTDPLGPETYCCHAYLTFVARPRPVPPPSFGLLAWTDSVSLTVAPTPKRVQLPEVKPSTLLGKKRYLLAGRRRAHRLQRAKEQDALNASFRQALSQLERSQRDAALAEAKANEPNQERLIASLQLEIVTEAYLRKSPDVRVEGEHIVGEIEGFVEPVRIQKAEVEAALKKRGHGSWHRIVTANDDEVERAGGHGGATVSADRTDGEVASHLDFADTLSMCLWIVRPQHANSKNLLFGGTLMRWVEEVSTIAARKVHPTASWTSAGIDSLTFKVATEPGWVVYVRAAVLKVYDSSVEIAAVVTCEDRNSPEPIVKHVSESFFTMVAVDAESGRPLKGALRPVRLPSGPISDMAASAEQRRDDRLLEKRVLQRVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B532</accession>
    <name>A0A2S5B532_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoserine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B532"/>
    <dbReference type="STRING" id="741276.A0A2S5B532"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28021" checksum="4D104A5795B8CC02" modified="2018-07-18" version="1">MGSEKLAHADARFILMSDFDGTITERDSNDTATDDLGFGVDRRRELNVDILNGDKTFRDAFAEMLNSVSKNGHSFDDVKKYLVKHITLDAGFKTCYKWCEEHDVPVVIVSSGMKPIIEAIFANLVGEEDAANIDVIANDTEFSDDGSWKIKFRHPESGFGHDKSRATAPYRDLANPPTIFFCGDGVSDLSAAKAADLLFVKVIPNHTNDLSVHCDREQIPYIPFETFDKVKDVIARIVEGKSTIDEELKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B557</accession>
    <name>A0A2S5B557_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000069">
        <property type="protein sequence ID" value="POY71919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B557"/>
    <dbReference type="STRING" id="741276.A0A2S5B557"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="179"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="720" mass="76438" checksum="4F4F902522C11503" modified="2018-07-18" version="1">MLGKRTRGNTVCDNAQHAAKRPVTALGASTKPGLSITATPAKRLATAMAAPSMSRSLSQKENQAVQLVHEFEEGNVFTVDDSVETPSPAAYTLSPPPVGPRPIEVKTEEEKPNSTRTIPHIYAHAASLLTTSSDLASSLPISGRQDQRETLLAFLQRRFPSVYAPREGGSSGSTTTPTRPGPAAMYVSGPPGIGKTALLSAVLGDFERQIADRELGAEVVVLMENCAAIAAGGTGADKAWEKLATGLGIDVARLDESSRTLTAKQRFEMGLQDGRKYLLVLDEIDHLISPTSPTRPASSAQPDLLNALFQLASIPASPLTLIGIANDLTLKALSLAPPPLAFSSSPEKGKAKADPLRTPSKPIRLHFKPYSWQELVHIVDQRLSLLADSYPFDLDVQQNSPPAEESAQDGAKAKKTSFPLIDKPALERCAKKIAAGTGDVRTMLDVVRRAVAAAAHQQAALPEVSLPSFTAQTAPKAGMKHVSAALASSSGLTVAPTLAARLAALQGGPHQRLVLVAVVVALSRLEKDGAGLAALSPSGAFESGGVAPRVIVDECYKVYRDFLQAEDVLKPSALDTSTFVETVGMIEDLGGFVTVRGRPGSSPSSSPSKSGGGATRRLTPTKKHERGRVTVELSPSAPMADLVTAITTAPPAGREAEEDEIARIARRLLERERSAQRWEVKRRAMGRDEDRRAEEELEGREWERSLQAAEVEGPSSTSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5E5</accession>
    <name>A0A2S5B5E5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY72002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5E5"/>
    <dbReference type="STRING" id="741276.A0A2S5B5E5"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000078">
        <property type="entry name" value="Mitochondrial DNA replication protein YHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="204"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="301" mass="31973" checksum="19B83EE497E356D4" modified="2018-07-18" version="1">MAIDAGPAIPGQKKRINWSNIALGGIMNMFEPLEVVKTQMASQRGDTIAQALKKVWSRGGVLGFYQGLIPWAWIEASTKGAVLLFAAAEIEGAAMGAGVGPATAGLLGGMGGGVAQAYATVGFCTCMKTAEITRSKMAVNGQEAPSTWKLFGDMYRKDGIRGINKGVNAVALRQMTNWGSRMGFARLAEQSIRKSRGIAEGEKLGTLDRVAASTIGGALGCWNQPIEVVRVEMQSMAKANAGDAARPAKPTIANTLAYIYRENGIKGLYRGVTPRIGLGIWQTICMVSFADVVKDWLNAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5N8</accession>
    <name>A0A2S5B5N8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5N8"/>
    <dbReference type="OrthoDB" id="2530433at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="491" mass="49491" checksum="06EEBCCEDF5F8A5E" modified="2018-07-18" version="1">MSSGSIAGTDGPAPNIGPATQVIPSFGLDGKPTTTASPSEDNGGDVFPLGAIALLAVIAGIALLVLAYRFYRWSYLRAQRTQAIEDYYGPESHALNPSARSPGPGGFASLPSQISLGQGGVDSMGRRSMSGFGGAGFRNRQTSWGGDSWGAGGLREKDGGDFSPPTQGSRAGSPVMYDASRPSLSGIPTQSSSRGSLAGPPRRGIYSSSTSGSQILSPTRTMSSFSSPALGANAGVFPSGNRIAGAPHNPRSRIEVVPPAPLAPPPGLVNATDKSTLDFAPTAGIGHATALFGSNPALAAAAAATAAGPNGSIASAPIVPVGSSSGNASTNEEWDLISGEEAQEHLDVAHDATSPYSAAPSLSPIIPPSLPSSSSSSSSSSRSAPLHADPQPHQPLPRLPAGAVPPTAMAAFGSAPVPFSAPTASGSSGSRHPRLPSIDTGGGIFTSSGRPDVRADEEVGPKSPLEQLQLQIERERKGLSLQHELAGVKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B677</accession>
    <name>A0A2S5B677_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B677"/>
    <dbReference type="STRING" id="741276.A0A2S5B677"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="185" mass="21066" checksum="5B27E7BB7E2A7002" modified="2018-07-18" version="1">MDYRYINHDELAQIIRTGQAGKTYQVVDVRDEDFRGGNIKGAIRAPSEQRTDQSVQDLVTRLDSVPQVIFHCTLSQVRGPKAARIYAEARREKEKQQGVQQRDASATPATGSHEQEEDLETAKEKARTFAPDPYAAAKATVADRAQTRQEVFVLRDGFQNWQGLYRKDADLVENFDPHVWQEYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6B6</accession>
    <name>A0A2S5B6B6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-coumarate--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6B6"/>
    <dbReference type="STRING" id="741276.A0A2S5B6B6"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="447"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="59033" checksum="FA7DAE42B658C317" modified="2018-07-18" version="1">MTIYTSPYPQVEVNLQSVYDFLLAPAKIRDFKDQAALVDATTGQQTTYAELAEESLRFADGLTSVARLRRGDSILIFSPNSILYPVLLLGGQAAGVVVSTANSSYLPDELAHAIDIAGSKVVLASADLLEIAQKAVIESSIPNATIYVLPGTDGKLPAAIPRGMRPYTDLRGLASFEPVRPTPQEAKRNLAYLPFSSGTTGKAKGVALSSANITTCVLQSSQSPELFGTKDTVLSVLPMFHIFGLVVMLHLTFYHGGTCIVLPKFDLPKALDAVQKYKCTSALIVPPIALALAKHPIVDQYNLSSLRYILCGAAPLSADLQQALQARLKGKTYVVQGLGMTETTSVGMIPVLTGAKPGYVGKLLSSMEARLVDVDGKDVKRGESGELWLRGPNIMLGYHKMETKDLTPDGWLMTGDICDRDEEGNYRVVERSKDLIKYKGFQVAPAEVEGVILNSPLVADCAVIGVWSEDQATELPRAYIVPSAEHAKSATIKEDVAKYVEQKLAHHKRLRGGVFILEAIPKSPSGKILRKDLRVMAAQEAQGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6R0</accession>
    <name>A0A2S5B6R0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein RAD51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6R0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6R0"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="7">
        <location>
            <begin position="97"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="8">
        <location>
            <begin position="299"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="366" mass="39321" checksum="D8B6A34000C9A6C6" modified="2018-07-18" version="1">MSQGSQGQQEFGEDAAGRVLPQPVTVLVAHGISLKDCEKLSEAGYATLEAVAYTPKKLLCQVKGISEAKADKIISQVSKMIPMGFTTATEFHARRADLVTITTGATALDNILGGGIETGAITELYGEFRTGKSQICHQLAVTCQLPCDMKGGEGKCLYIDTEGTFRPERLLAIAERYGMNGEDVLDNVAYARAYNADHQSNLLVLAGAMMSESRFASPHALETGVHVTYLVRVCRRFSLIIVDSVTSLYRTDYSGRGELSARQMHLAKFLRSLMRLADEFGVAVVVTNQVVASVDNAPGAPADARKPIGGNIMAHASTTRVSMRKGRGPERIARIVDSPCMPEADAKFQITAQGISDVNDGADDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B787</accession>
    <name>A0A2S5B787_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">BMF94_4472</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B787"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="94"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="283"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="449"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY72644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="479" mass="54182" checksum="E694014942D29FA7" modified="2018-07-18" version="1">MGKRLNRLWVVGTVALISFIGYTSQIFVVFPAVRYRFSDPELLRVLLPFNILLAFVFYNYALTVRTDPGRVPKGWRPDPRLLETGHIEVKKQTGGPRFCRSCQEFKPPRAHHCRQCKRCVLRMDHHCPWVNNCVGHHNYGHFVRFLLAVDVACTYHLWMITTQAMNAMERFVEPTTTQIVMLVLNYTACIPVIIAVGVFSLFHIWSVLTNTTTIESWEKDRAVSLKRRGKIREYRYPYHLGYVRNVQAVLGASPLWWFWPQATPGDGLAYPVAVGTSPAQQLEWPPRDEFVPTRRRRARRSLAAQSPFTYGDGLNPALATNPTTVESRTAESAHRPDAAMRRRRPVERDPAEEDSASSYDSTTTPGSSSDEDDGGALSVDHDEDDDVPLGQLAARRARTAAAHVGMGACVEDVDMDEAVGDDDLAPERSVRIRRGSEGYEIRPRRAWAVAESGNSDVSDDWQQVEPEESERERDTKVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7A6</accession>
    <name>A0A2S5B7A6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4493</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B7A6"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BAH" evidence="10">
        <location>
            <begin position="879"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="295"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="860"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1700"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1755"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1715"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1781"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1816"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1825" mass="200771" checksum="F50E9B9A61563033" modified="2018-07-18" version="1">MSHQTGGAPQNATATATAPPPPPIVLNKLSLDEFRQLQHKYAVLFHKGGRDPKRIAEGQPYQERGFDAIAQEAVNELWDELFEQRERPFPDDHLKKLQEIVYIERTVNYHSSTTRYKGDKFLVHRHPDDILGAPELHIPVGYCAPRCEIDLDDEGEDVEHDRSGARRNLWLRQFEVELSASGLRELEDGGISPLDLWELPRGDHRLQFHPQYDGDDDDSDVEEGPRHASSGIDGPSGEGDEAIGQGGMQEDDDFLEYKTPPPAAQQLAILAAEAGSRNDLSPAPEQLDARQAIGGSDFEGDAEREESYGGGADIDFYFDSDIEVERDLGIGTSTNPPPPPGPASPGSASPSPLHEPEPELQDVAPAQKKRIIRKQKAKAVTSAAEDGSGEMGDKKGKGGEREMGEHMPPVKDLAPLKKTTTRSAPANMAYRPRTQGKRGRTSNKVYAPRTSYAKVQLTRSANCFSEDRLAAAFPAAAKSSKPSEAQIRGKNQQHGWVEPDSDGDEDEFATGAGEYKHFLLSSFRVLRTKEVKQDDVRTAVITNTPVDLMEVVMRARRDLVVVGHASPMASASECDDQGPDPAAADLEVHLFGYEIRGTKVTADGIVIETSSRKYRLTTAASRPFAAGRPNHCEHSSKAVPCPARLAASYGVPFEAQTQISRRVLNLFVFARSRSIRGNHTKPRASEDEVEEAVADVARGIKDELAIARNAGDDSWQRRLSPYWRIPIEQLSFDECQDGHSLFYLLPNIPFILPDIYRKIAPHFSPNSFHTDDAERQDELTRIAEEEKAALLSRCFATIEEDENYEVSDMVELLGKPQKGFKSTQTDRDGDRSVIEVYSQARVNQIIYEIGEVVLVRPTTRPLGPSHHRDGSESIAGSSDDGEDSDSASIVPHRDLTEDVDDRLWIARIQYFWAADRDDDMHVYVHLQWFARGNAVPSVGDYLDSRQLVLLDRCDDSPAGPILAKLELVFPAIGEQPPSDKFYCLTQYSCDDGSYKDVTSARPAGSLCDIERLFPCQSCETNLDYLAGTGEAEVEGAPRPAIALRLDDGFRLSGVDYHPDDFVYLLPSRTAAIAADDPRVLPPFDLAQFVGIHDDMTDERGELTLRLHKVERVSHDALGSERLVDLTGREIYSAATDVAGKFVVCPSPDEDNIEAFVARLEMASEHAFWTRSASFPRCGRCQLEFEQVQALKAKLGQAMEKSARARSGKTSQHVELAHLAVYAGGGLLDHGLEKGCSLVRVRHAVEHHGPALSCLRSNALHSLSSYEDAASNLIQRLYYRLADPDGQEEQDDLPPPGGVFSIAGGSPCQGFSHANRYKQADDPRTFEPFVFLNYVAIYRPLVALFENVAAFTTHALPEAGSKPGSFFKLFVAVLLELGYQLRWSIVDAAGFGVPQHRRRVVVQIAARGVPLPEAPEPSHSLRRAVQPVDHRLLTDRITRPANKTAVNWAPHAPVSVKDAWSDLPAFSVHEMQAGSRKFGFGWNATQPPPYATPAHSTYQRAMRLEIPPDPTGELTYNSGVTFHLCHSLSDVVVARIKALKPRDDQKGEGGHLDMKGLVCYPVPPPWVAAKKSKLARWWRRLRPQSILAPLRTKLNIDGASHGERIHYSQARPPTLREFLRAMGVPDWYELNFPSDVLDENLEESMRIIGNGVPVPLARAFGAAFFDVLAPIADAWTGDDNVWSDLWHKINGQLASRAIDSVDMRDSSTRSPSPAAQGPPAPPLAAPRPLPRHGGSSGYMYATTSTPFAAVEAEAGAVKSNKGPVARPSGAGPARRPTGYDPTETDSDDDIEIIARPSKRPASSEGTPAKQYSPDVIELSDSDTDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7L4</accession>
    <name>A0A2S5B7L4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7L4"/>
    <dbReference type="OrthoDB" id="3359339at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="142" mass="14953" checksum="B0F854D81E4F3896" modified="2018-07-18" version="1">MSNPYEGKSDADIIAEQAASLNRKADRFDSSASFDPKRTSLGDESSVNESGLQDEFPGSTVEVGRTGRTGGGDNLTVPVEEGGDDRTNGSRASEFDNVPAGETQTSYKAKTQPGDINVSGGRQEALRSIDAPADGQPQLEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7M0</accession>
    <name>A0A2S5B7M0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4183</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7M0"/>
    <dbReference type="STRING" id="741276.A0A2S5B7M0"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="172"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="434" mass="48048" checksum="BF882E208DBBC5A7" modified="2018-07-18" version="1">MATSKPRFFLGNARRNAAPTAASQRGTASSSASSANNKVAAPPAADLALVNPDGDRRMGVISDPSDQCPICKNDRYLNPKLRLMVSKCYHKMCESCLDRLFSLGPEPCPVCGQTIRKNQFQPQIFENLEVQKEVAIRRRTAKVFNKQPEDFATMEAYNDYLEEYESITFALIHSIGNDLAETERKIRAYEAENRNSIDENEERLAREKERLEAQERGEREWRELEKRRYLEEEERKDRERAEERKRVLQQLEEGKLSPSTIMAASADRIKAAEAASSAKDAKSAPSAYASDNAPKLKFLANLARPSARSTNGASPSGGALDPLDEADYAPGGLLDPLSDYQHAAFAGLYDSHEPLYTPIASTSYKVGLGPLVAEREREQNDPVVKAGGFRADEVFEKAIREALMGPWEAPKEWDRAAAGSVTEAAAPMQVDTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7P7</accession>
    <name>A0A2S5B7P7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7P7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7P7"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01014">
        <property type="entry name" value="nicotinamidase_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="180" mass="19688" checksum="39761FFD80EBCE37" modified="2018-07-18" version="1">MPTALLVIDVQQGLCVGSDAVEKAGRTIDNINQLYERARQAGAPTIVVQHDEKDDLVYGTPDWQLADGLEHHQSPHDIFVRKQGSDAFHETALEQILRDRGVTRLVVCGMQTEFCVESTVRRALALGFEVTIAEDAHTTAPNGILSVDQIVAHHNKTLSSLGSYGARATLVASRDIRFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7V4</accession>
    <name>A0A2S5B7V4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7V4"/>
    <dbReference type="STRING" id="741276.A0A2S5B7V4"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="728"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="783" mass="82598" checksum="10D9D2FA44D87032" modified="2018-07-18" version="1">MAGSGRFHVAPEQAALRAQANHPDASRGKFGTRRTSAAANSWSTNDRAGGGDDAADRGEGTRTRAAGGGGGGSGGMNDAANGGVKMVKMSGNKRRAAGNGTASELSPSPGPGAAAELDNEDDLGGFVTGRDGDDDDDDDDEDAPTTTTKRKARFPNKRNAQSVGRRKIHIEFIEDRPRRHVTFTKRKSGLMKKAYELSTLTGTDCLVVVVSESGLLYTFSTPALSGVTDHPRGREFLEAALRGDIRGDGTGDVDFGSPGGESGGAATNNTNPRETDAGRGMRRTRSDGDQQQQQQQRQSTTGAVAAASPAHHHFPTDFQLDPALGALDLPVPPLPYPPQHVSTSADSQQQQLYDIFQSFTAATPGPSNDFGSHQNDTSHAFEHDSFTFEPSALYSAATSHAATTSSSAPVLDLTSLQSPSASNLAAFLAGEATSFQAVPSSTAQVSTPVPSVSNSSMSEDVARAHEMATRSYRAALKAAESFFPASAPKAFESRPPTPTLNGSGSSARKRALSAGAGDASELGWDRRVRGKATVAPTPAEEVGLGHDENEDEDESVEERKSRWGKAAREALREAKSSGTIPSFLRAHAFSHYASRSYPPAFDPSKPPYSLNQEHDAMMQASFARMCCRGGVEAKEDLVAAVQEFLVRWLPREMFRNPSFEPVFLPPALGHARAAILSLVDFLEGHDLISYAEMNRVSAVLKGQLKAQAGYEEVEGLGLAREERLYGGGAPKAVEEDEPKSAAEENATASPPMTAGRASVGLPHDAMPLMTDEGGKEADGQSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7W7</accession>
    <name>A0A2S5B7W7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_4032</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7W7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7W7"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="14">
        <location>
            <begin position="55"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="753"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="784"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY72872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="857" mass="93863" checksum="1BBD102DAFAF069C" modified="2018-07-18" version="1">MSRLTVRVIAKSTPLPIGLVACVYSLPPALVKLEFVHSLDSTTDANCSVQLAGQDSQVYGLVDCYKAIADAFADQGKLAGTCNKDSTAIHALLLDQPPFPPAFPTATKFLQLLEHRLTLRAFVAGTHAGPSVADYALASSLKNNVIALGLLNKAPHTHRWYSYMLQLPEVVKAIADVATQSKVKPAAAAGGAGGKGKGKGNDADAPANAPGANATFELGLPNAVKGHVVTRLPPEPSGYLHIGHAKAAVLNQYFARMYDGKFLVRFDDTNPSKEKAEFEQSIIEDLALLGIKADATSYTSDYFDRLQQMAIQLVKDGKAYADDTEQELMRDQRMNGVASKRRDLSPEESLARFAEMATGSAEGKRWCLRAKMSVDDPNKALRDPVIYRVNDLPHHRTGTRYKIYPTYDFACPVVDALEGVTHALRTNEYRDRNPQYQWMLDATKSRQVEVWDFGRLAFVYTLLSKRKLKWFVEEGHVGGWDDPRFPTVRGIRRRGMTVEAITQFMLQQGPSQAFLNLEWDSIWNTNKKVIDPVAPRFVALDKEGLVRVKIVSGEGKPAPGQVESKEVLKHKKNPDVGTKTTFYADEIFVEQADAASFQQDEEVTLMDWGNAIVRKISRSGAADGPVESLEMELHLAGDFKKTKKKVTWIAAPSDVTPVTLLDYDYLITKKKLEEDDKVEELINPKTEFRTAAIADHNIRSLAAGTIIQFERKGFYIVDRAFDSSKPDQAAELILIPDGKASSIALKYQDPNTPAAGAAAPAAKEGKGAKKAAGGKTPAKDKDAAAQAKKAGKAPGVKVGLPEMAPNEPVDSVLKSEGSKGYHIAVRTKMYRVEPPYGTQAVETPVDTKMHEVKPFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8I5</accession>
    <name>A0A2S5B8I5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gaa1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8I5"/>
    <dbReference type="STRING" id="741276.A0A2S5B8I5"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="72630" checksum="002E86F227C22160" modified="2018-07-18" version="1">MMIPRLRGLVARRRAAGSSDETQKLRKTLERRRLISAKLVAFAPYLRTLLVIAGLLYTLALPHQLLGRGHYIDENALQPGQVNTYWNWADVHVADRYADSAANWNELPFDRCAAQGSIRRRNECSHFRAARSRTRSVKDAFQDLGLPTAVQNYHFDVSPTSNVSGSNVYAVLAAPKTDGAEAIVLSASWLSRAREHDGTQRMNIRGVSLLLAIANYFKKYSMWSKDIIFVISDGYSDGMQAWLDAYHGAGQANLHADPLPLTTGPIWAAVNLDYPHHSFSHIGLYFEGANGRLPNLDLVNSASKILHHTGIPPLLHTYDPKSESPAIGRFAASLPEVARKEVEKYWRSAANLFRQVALGADGRVLGPEGSFGRYRIDAITLFGVPAEGPHGFHALGRATESLVRSINNLLERLHASGFLYLMTSVETFISASNYLAAPILIGAGLTIDGLLTWAQAGRDPKGQARDRPVLLAVVLLGAVVGVGASQVAIVSHVDPMRKLPEYLSAGLLSVHLFMPLVVVNLLMSRLVTPASAARLPFSVAALSRTVRAMLLLASGLLISISATLNFGLSLVSAIYLASVLFLLAPLHRRYHLRKTLPRRIQQFALALASPVGLWTMWRIANRTAAERWLSDLLRDWHVGGGWSLPVALGLVGPLVILQAVSVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8X4</accession>
    <name>A0A2S5B8X4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8X4"/>
    <dbReference type="STRING" id="741276.A0A2S5B8X4"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="410"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="798"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="984" mass="107402" checksum="4223572896A83DD4" modified="2018-07-18" version="1">MAGAQSWRSGLATIDLTLSDSDRSPAPVRKQKPPAALVERTDGQSTARRRLPRIPDSSDDSDTGSSDSDGGDDSVEITRPAERQAQGPAQAAPPRMAVPALGPPAIQGAGAQETQPPRTFKAPQSSSGSLFRTGPAHNKLFVPPQRPQPPPPPKPLSAFYQNSQGRPNNRELSTSTAGVTGSSDARQGPPPPAFANRNTNANAPSWLARPAEPRPNAAQGASANAFSKMPSFYRPRDPSLPPPTGPSPTLSVKERAMADLRAAQQKIGVPIAVPQNPPRSKTQHAFAKRPSDPKREAAEPSIDDDGALEDAMNGLSVRDDLRDGGQEAALQDLLSSVADIGEVDTSEPPPDGLTCDLLPHQIVGLAWLKKRESAGPVEPKEPEEELTDLPAPSTIGRDDPKKQSKKKKKASGNGEKFGGILADDMGLGKTIQMIALMLAHPSDRKACKSKTTLIICPVGLMDQWKAEIKRWTDDRLRVLIFHGKTRPTESRVLHKYDVVVTSYPTCQQAWNGPKKKQKGQDSDDGSEADNTSPLYHPDRPFYRIILDEAHNIKNPSTGAHKACVALRARYRWCLTGTPIQNSVMDIHSLFAFLGPTVVRPLHEISEFKAKIEQPIKNKRAKIGLARLSVVLQAIMLRRVKTQLINGRPLIDLPKREIIESKGPFLNEKEAEFYRNIEQKTADALKEQLKEDGGANYVRILTKLLRMRQACSHPSLVTKESVLGQQEALEPKPAEPRSSGKTAGDDLADLLDVMSIETRICSLCSTTIRGGDKSSSECASCLKDLERYKHLSSSTKVDRTLKLLRSIKRESEAPGQRPKKTIIFSQFTSMFDILEPFLQSGGFGYVRYEGSMPPAARTEATRRIREDPGCTVIMVSLKAGAVGLNLTCCSRVILLDLWRVGSASKSWNPAIEEQAFDRAHRMGQTEDVKIYKLTIDDTVEDRILTLQADKAQLAKAALEGSGNVSKLNKLSMKEILYLFKANAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B904</accession>
    <name>A0A2S5B904_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B904"/>
    <dbReference type="STRING" id="741276.A0A2S5B904"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="267" mass="29291" checksum="21CFF66DC5387BE4" modified="2018-07-18" version="1">MSSIGTGYDLSTSTYSPDGRIFQVEYANKAVDNSGTVIGLRCKDGIVLAVEKLVQSKLLVPGANKRIATVDLHAGVATAGLLADGRHLAGRARDECESYRDNYHIRVPTKILAERLALYFQAYTLYSSVRPFGLSAVLAGWDSPISTVGSDTVVERKQEGKPALYMIEPSGTYCGYRGVAIGKGKTEAKTEIEKLALDEMTAEEALVEAARIIHSVHDEAKDKDFELEMTWISPKSDWQHRPVPKDLADEAERKAKEIIDAANQMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9E7</accession>
    <name>A0A2S5B9E7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9E7"/>
    <dbReference type="STRING" id="741276.A0A2S5B9E7"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="47"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="260" mass="27886" checksum="2A14FFDB5A588CA5" modified="2018-07-18" version="1">MSTPAQVVKLRAILATALPGLQLPALPAVSNTIWNKHASFVGAQHHAFQRPVDSQDNDYERLEHVGDALLGSGVTLLIHQQYPRLVVGARTLIRSALVENITLDQLAARYKMPDRILAAAAQRHTIQNNANVRASVFEAYLGALHEEAGPGALEQFIRGIYLPLVPKLVDALRDMQTTSSISLSSAVPLASANCVGLLGEWAVARGSHGRAVTYGPPEREGCDHAPLWFVTCSVKSKPGALYPTELFTGEGSTVAAAKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9G4</accession>
    <name>A0A2S5B9G4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Capsular associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9G4"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="56712" checksum="6F3247347E04B443" modified="2018-07-18" version="1">MGATPKPAHCGFVAPAARPWHRMGRAWSRSSAVLLFLCAGGIAVVHYTLASPRILRPVRSVVASTAPTLLEPTATSSCEVCLLEPTNPLCRYGLVNIRLSRAYEGSGHRLRKVLRKALAGEEVGIGGLGASVTAGHAVPPGEQRWEDRFFEDFQRYFPNARMHVGAAPAMDSQFFVYCAAAMIPVDLDIYLIELDINNDMSINTVQSDDALMRSLLNQPQEPAVIRISVLTLMFDELVQGASSGLITSQFFDVPVISLRGFMLPYLIQHREKAPEGFGIDYLGAIDYRHISAPVHRTLGDMLSLFVQKEICETRRQAALDTSALPLARGLWLEDGDLGRVPNLTLWSSWLRPAEPRQITPLCQSLGSPRSPFAPLSHSKTFEIEEWNGKTAWMASLPGSQIRMNFTGSRLGLFVYISNGRNPQESSDDLAVRRRHAPGSATCWIEDAVTGKDDEAAAREIDMFEIDTYLPSRGASGFDFVELAEDLAAGEHILACEVSSTSQSGGYRWRLQGIASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9I8</accession>
    <name>A0A2S5B9I8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9I8"/>
    <dbReference type="STRING" id="741276.A0A2S5B9I8"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="587" mass="62059" checksum="F9705570906D89B6" modified="2018-07-18" version="1">MDRPPLPESPASTVVTSAPPSEKPSLEDGRASEEAGDVQLQPTAKKPSLRGKGVRFWLVVLALCSSGFLSALDLTAVSTALPSIAADFNSNNYSWVASAYALTSTALIPWTGGLAAIFGRRPMMLIGLFIFALGSALVGAAQSMAMVIGGRSVQGVGGGVILTMSSIVLTDLVPLAERGIFFGILGAVWAGASAVGPPIGGALASAGAWRWLFYLNLPLAGVAIVLVFFCLDMKEPETTWSEKLAQMDYVNVVFVASATAAILGLTWGGTDYPWSSFRVLVPLVLGFLGMAAFVYVESTPFVKHPTVPFDVLRHPTSLIGYVISFMHGIAIMAIIYFFPIYMQACYGASAVQSGIDSFTLSFTIAPFAILGGISVVVTGHYKTQNLVGFGLAAVGFGLMTLLKYNSSTAAWAGYTVLVGLALGILFPATEFPVVAPLTPAQQPQGPKRRVTESLTRVTFTNFVRSFGQVFGISVGTTALGNQLEKNLPVEFARSIGKASNAIAAIPYIDKLEEPLRSQVRAAFADSLKVVWQTCIGVVGFCCVLSLFMKSLPLATTTDEENWGLKDREKAAAHEREAAIAAPIVATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA55</accession>
    <name>A0A2S5BA55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA55"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="157" mass="17021" checksum="95ECCDAF5E195396" modified="2018-07-18" version="1">MSLRPSFIRLAQHARQPLMKFPDRKAQHASHDPEPHPCAPKEVVEAFSRFSEVRANPQLATRKADAAASSSYGGPTADELKRQGQGQGSGASSGSGQGKGGVAPGGTLESESQLPAWLRRDRYAPTEEEIDAVMSGGATSSREFTKQYQKLWYTAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAT1</accession>
    <name>A0A2S5BAT1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_3037</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BAT1"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015428649" description="SSD domain-containing protein" evidence="13">
        <location>
            <begin position="22"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="830"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="905"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="934"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1025"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1104"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1332"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1355"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1380"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1407"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1457"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1492"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="14">
        <location>
            <begin position="892"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="401"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY73867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1557" mass="167591" checksum="57EF76A08CBD60DC" modified="2018-07-18" version="1">MRSFQRLDVALSLSLIGSAAATVDSDPRNAVPAPLHLASTDRSPTSRTAAPEVEFRREQGRCTMRDSCGRKSIFGGEIPCPDNGLATRHDDDDDKEYLALLGKVCGDDFSTTTCCTAGQLEILESSLQQAEPLIALCPACKLNFRHFFCALACSPDQSLFLTVTTTQSLTKDGKPTVAVKSIDYAVSDEFGSGFFESCRNVKFGATNGYAMDLIGGGAQDWLAFLRYMGQERALGSPFQIDFPAPSGQLAPLSSASNTHPTTAFSAASPPRPFDDVPLACNSSDPAVRCACPDCPPTCATLPARLSSRERYERRCRVGKMDCFPFALVIIYAVALAVAGAWGLYRLATGRNRTWGDGDLDDVDGAIRLAEDEDAMLPPAGLSSYDDESTWTRLRRQLSLASLRRSNGNSKKSPRTSVAQATRSRSSTDSTIRGNNGVHEDATGRIGSRAGRPRGDTGGSDTSPSVGAGGSSRSRSTHAGSTSSQSHGISLVNAEETAAQSQPKTYRFNNILSEFFYRLGWYCASNPFLVLAISLAVCGLANAGWARFEIETDPVRLWVAPGSEIALQKERFDRAFGPFYRTEQIFFSVAPARLRQVDEGDENDDASDLAPWNPVDEPVLSFETLQFLLSVEQDIRALRSTPRNLSLASVCFAPTSPSPDGIATSADDCVVESVLGYFQNSLDDVTPDDWAERLDACTSSPVSCLPTFGQPLNPKLVLGGVPDGSPTSQARAAIITYVVSNSLDPEVVQRAEEWEATLKGYLRALAQPSGEAAQRNLRVSWSVGTSLEEELNAATNTDIPIVVLSYLVMFAYVSVSLGGSASGCIRTIGRLCLLTAAGIISGATWIFRSVQRSFRGGQIRLEEDAPDGSGVRGRSNSLSHSLAAGSLSGLGAYFKRQVLVDSKFLLGLWGIVIVLLSISTSAALCSAAGVKVTLVIAEAIPFLVLAIGVDNVFLISHELDRHNAQVRTGPQASLADDEDEDARLAPEERVARTMARMGPSILMSASCQTVAFGLGALVGMPAVRNFAIYAAGAVLVNAALQLTVFVSALTIDLRRVEANRIDCFPCFKVASAAPADTAFSSHESILSRFVRTTYAPNLLRPATRVFVLAFFAGGFVLSWIGARHVSLGLDQRLALPSSSHLVGYFDAVDAYLDVGPPVYFVVDGLNSTARPNERKLCARFSTCEQLSVANVLEAERKRPEVSYLAEPPAVWIDDFIAWTNPALEDCCRVRRASPTTFCSPADSDALFDGLPEDEDFMRYVRHWLESPTDEACPLGGRASYSTALSLSSAREDIEASHFRTYHSPLKTQDDFIEALAAAQRISAELSKRTGARVYPYSLFYVFFASYSTIRSMARAVLTLALTAVWIIGSIFLGSIRTAGLVTMTVFLTLLSVVGVMGVWDVSLNPLSLVNLVISVGIAVEFSAHISRAFMGSTEGGLPVPLSKTRHDRTVRTARALDAVGASTISGIGATKLIGITVLFFTQSRLLRTYYAKVWLATIVSSALHGLVLLPVLLSLYGSSGYALTTQDGDGDWIIGSVERRYAARPYEDDLDSLDSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAT2</accession>
    <name>A0A2S5BAT2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone deacetylation protein Rxt3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAT2"/>
    <dbReference type="STRING" id="741276.A0A2S5BAT2"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="973" mass="98205" checksum="9678FBEEFBBC4002" modified="2018-07-18" version="1">MAESQATPAASTAAPVGLTPAAPAPVAPTGGQPAPVNNPPTTAPSILPGAPLSSAEKSLFPSAMPGGSRPLPGLPNFGSPAPAAPSSTGGATPSSGAGAAGSPAPLSAASPPYSAGLSAPASRIGQTGRSPSATSPYAPHAPSKSPSIPPSAYPGHGATPTPPIIPPPAAGRSPATSPNPPRAATVPTTHPQQSPPPPPSSSQAAGSGTVAASSRGNPMSVSSMLSGPSRDRPVAAYSPTAAADSGAAAPGTSAAPVVSATPTATTPQSGGSAPPAPAAKAVGTPQPPVMPPSQPAVSKPPASAPASANSATTAPAPNTATPGGLERSSYPPLPSAYARESPYAPAPGGASNPSSRPSGQQQQPASGGASYQHSTWSSASAALAHAQAQQQQAKDSLFPAAGGSAGQTPSPGGAAARPPSTNGPGPYGSSAAARTASGLQNGASTTVPTASTSANGTNGGAASFAWQAQAAQQAQQVQRERERESDASKSALAAAMQARPGQVGQASQQQQQQQQPPSSSASYGAVRGHTAGTTPPLSNGASATAAASGHKRRRSELPATTAAPVTAEPAIETPPAPPPAAPAPPLFSYADQRRACIRPPMVEVVNEAIDAWERQHREDGEKSGRRPFCGRVVYDALVPPAKLLDGDVLANGVGGYVEILVPTTWILGPASSRPLADSQYEPVRSTCSVPPRDLPPVAFSVGSPASYAGEALPQTSPSTPLALPTHLADLPGFRKRQVWGTDVYTDDSDILALLVHSGWLRVTRRERKRRAGEKGAGVDAIRRARIEGEERIEIAAASDAEGAAIADAQAIKVTLGVVPPLVRYQGIERQGVRSRSWGNGHDGVSLRVEHVELLQELPTIRPPRLRKSVAAEVAHQLATWDERLLVAEQHEVDQLHTLKRREPLVSMRPPKRYRLDRSSPADGVADTPAEPVVISDTFVLPLGEGAGRFVDAEEAGASADEDGLDTTDAMEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB99</accession>
    <name>A0A2S5BB99_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB99"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="484" mass="54227" checksum="A77137FA3F00CD94" modified="2018-07-18" version="1">MEPRDRRRSSTSTAPARYQFPQGQRIVVTTPAWARNLPPDELSDDEDPGVRGDLVPTRSTAGSSTSPRRNPAATSGPGRANGSVQPRQSPTSYTNGSAARSPHETADSPATSSSPPTSAEQTTPLLPSPPPEAHAEDEVQRNGAGRLPPPVMNAHDRGWWTFTLPGKYLDRVHGYINYNEKGKLRTRESELDTGIAADQGTDDEDVRSMRSTRSVRSWISRASRRSRTGDVEKREYHNKMRNHMSLRLPTAPKVFSMNQTTTPGWSQPWTPFRRERTQNDLLDPFELTQQQTGRQSKRSRFERFILENPFSPLFLRTINLCLIATTLGLASRIRLLEDRHNAIGIIGSSTLFAIIVGPFAIVHIFITLYIEYFGRPIGLWRISKKMFYTLTELIFICLYSAVLALVFGDLFTSSLECTSWTPYRRYNLPPPATVGSAKVDGSVASEICNEQIAQVVVIFVSVIFYIIVLVISLWRIFAKVSRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBC7</accession>
    <name>A0A2S5BBC7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBC7"/>
    <dbReference type="STRING" id="741276.A0A2S5BBC7"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="130"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="240"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="339" mass="35876" checksum="700F87BC694AD57A" modified="2018-07-18" version="1">MHARLLRSSRSAIRTVQTGARLVVPPSAAVVLPARSSALASISTRSFVSTSFLRSDSSSPAPAPVEATQEPAASPAQIDQQAATELPTDEIPAVSSSLDAKASTAESTETPAAVAKSEPTPEEIAEKVSRTVFVAGLSWSVDEEVLREEILKVVEAEEGVNQIRIATDPAGRSKGFAFVELASTDLTQQLLRSPTFVIDDREAVVRPSKSPVGTTTARGSGSKKYPTQRGAPNARFPPGPTIYVGNVAWSADEIALEEVFGRYGNIKRINQPKDGETGRSTGVAFIEFETLDSAQKAFRAGNGRGIKVDGRPVRIDFAKNGTQQQDGERTTSAAGGKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBJ1</accession>
    <name>A0A2S5BBJ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative NAD(P)H oxidase (H(2)O(2)-forming)</fullName>
            <ecNumber evidence="7">1.6.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.3.1" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBJ1"/>
    <dbReference type="STRING" id="741276.A0A2S5BBJ1"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="122"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="162"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="305" mass="33134" checksum="5AFB0FB68BA1A853" modified="2018-07-18" version="1">MPSIRPTMLSRTIASQLRIAAARPVAAPVLRSAFSTGASRWSSPTPVPPPQQPTPGSSKQPVAASHAEPAAGGAKQQNRTQAGPFTLKAGALFVATGVGLWFYFQAEKDKVRERKRMETAAARVGRPKIGGPFLLTDQDGKPFGDKDLLGKWSMVYFGFTNCPDICPEELDKMTVVVDSISDSHKTDILPVFITCDPARDDVAAVKTYVKDFHPALVGLTGTYDDVKKTCKAYRVYFSTPPNTKPGDDYLVDHSIFFYLMDPTGKFVDAFGRSMGAQDVANKVRGYLDEWNEFGGKGSWSDAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBJ3</accession>
    <name>A0A2S5BBJ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_2958</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="4 12"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBJ3"/>
    <dbReference type="STRING" id="741276.A0A2S5BBJ3"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 12" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY74146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="586" mass="64759" checksum="A379AA86B2FB7D45" modified="2018-07-18" version="1">MTSKPAQPVALEADAPRPLPRLARPPSVADWIPTVSIPVDCEPAHFHEGLLQLVLYPEQSSSTILRAEILDDEQDPADHLDLAGGDAQTRCPLTGYTCVRRVRRRVLPNRPQFDWAMEQECLFYDKRGSEAGESEALVVLLPDFAQLDRDRGDQRLPYYHPQVYALAFRYLADHAGTSTSLRIDLVPLPSQPLLAPLPQNDRLFRTAQVLAKYAAKLCNGQAVGYQKRIHHDLLVGRTAVQDTYQRLKDKYQWMLHSWQESTDATKHVFEDVAIAAWLVTYWAEIYPDTEGKPPGGFVDVGCGNGLLVYILAAEGYSGYGFDLRERKSWASYTAPRPDLRVQSLNPVTLLPSALDHTDSEGASGSAESSDWPFPRDSFLIFNHADEMTPWCPLLAALTPGPRVGFLNIPCCLHELAGRFERQTYTIPAAFLADLPPSQIAADHPSADGSEAWRASLPDDLHPLLFPFYAAAPLSYSKPAAKGATSAAAASPTGDVSILGGRYHAYQLYLAHLTLRCDFVPAREALRIPSTKNFGLVGGRAPRSPGGTGRDQEDVRDEVRQLLAEVVRKGEWRARRPEGKAGERSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBJ5</accession>
    <name>A0A2S5BBJ5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2961</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBJ5"/>
    <dbReference type="STRING" id="741276.A0A2S5BBJ5"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="125"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="398" mass="43368" checksum="2CB0C84AF514FF6A" modified="2018-07-18" version="1">MPAFVPRRVASSGIRSLATTASPSPIASTSAAGAAAAPHRPRLDKLRAENAQIDDFLGPDGAPGASRDRVVFTKNKTPRLPSYLKTAIPTSASYNKIKQDLRGLKLHTVCEEARCPNIGQCWGGDKGDATATIMLMGDTCTRGCRFCAIKTSKAPPPLDVHEPENTAEAISRWGVGYIVMTSVDRDDLPDGGAGHIADTIRRTKSKAPHILIEALTPDFAGNVEAIQQVARSGLDVFAHNMETVESRTPFVRDPRAKYRQSLEVLRVAKAAKEGLITKTSIMLGVGETDEEVLQTLKDLRDNNVDVVTFGQYMRPTKRHMKVSSYISPEKFDFWAKQAEELGFLYWASGPLVRSSFKANELLKSAAGKRLLQGLRGRDGGVEAITKEGERRIIEGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBR1</accession>
    <name>A0A2S5BBR1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBR1"/>
    <dbReference type="STRING" id="741276.A0A2S5BBR1"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="136" mass="15322" checksum="A1960E9D0458C736" modified="2018-07-18" version="1">MARTKQTARKSTGGKAPRKQLAAKAARKSAPQTGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQEAAEAYLVSLFEDTNLAAIHAKRVTIQPKDIQLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBZ8</accession>
    <name>A0A2S5BBZ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBZ8"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="281" mass="31287" checksum="FA74963507AB2326" modified="2018-07-18" version="1">MSTSYEMTCCVCGAPADQRCGACGKSGVSVRFCSREHQRLVWPVHKLVCGPDKANPFKMPQLSATELKQLADMSKWPAVGSGRSPNQSAMGSQTLGDAMNAEISLFRRVTLEKWLKRPTALTHDLLLRVRHDMCMTAIGQSQFRRYTADPLAFVALTESIVTASEYHYPQDRVQDILHRALALAAAVRATTQDTLDHDSAVLGKADLVRAYTAYLRDVAARIVWPTHKLAETELSMLSYPFTLTWHYQLALIMDAPERHVLSVSLVPRDCSCRAHYGQAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC31</accession>
    <name>A0A2S5BC31_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP12-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC31"/>
    <dbReference type="STRING" id="741276.A0A2S5BC31"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31727" checksum="BB225210BBAA7D54" modified="2018-07-18" version="1">MLRALVPRRLLARPATSAAACARCCFSSSTRVQEAATSQTDQAEKQMRRFWKTVGLEVKPQGDYAVLLDKRTLKTPGGAPLTVPKGRLPVALCIADEWENQTAVLKPHTLPMTSITSRALDGLQNPDMRKDVVAYLLRYLDTDTVCFHESFPDRLVALQDAHWKPLIDWVEKTYSVKIELYDSILNTRQPDATVLKLGSVVSDFDHFKLAAFERAVLASKSYLIALSLVEGYFSVDEAAKAAHVEVQSQIDRWGEVEDTHDVDHQDVRVRLGAAALLVAEQPQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCG0</accession>
    <name>A0A2S5BCG0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCG0"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="130" mass="13851" checksum="0EEFE80E578B3652" modified="2018-07-18" version="1">MATASSSVMSKATSSDYTRVQAGYKAAAHNKSLQEETRKNAEQMLRDLEAQHDKVAGGEGAAGDGEYKPSGAGASNVSTADQSTTESHEETVHEHRVIGGLKANLHRSDRSDETKESVKAKLHNLGVDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCG8</accession>
    <name>A0A2S5BCG8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCG8"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="490" mass="54139" checksum="3396F5BD407DE2ED" modified="2018-07-18" version="1">MTPTRFLSLPDELLSAIIEVTAESWQSTESHWNRAVLRQSTLTALSLVCRRVGRLAQTCLHVDIHVQSAIGLASLANTLHVRRDLRCSVKRLHIEYRARLNGSDTYGRGYIGGGYGGGYGDARTSSSAEGMYECAQRGLLSAPLGALKELELSSMPRALLMEALAQAGVPGIVPALSKLQLRYYDKSDRASVWKLVAALPRLTEVAFESPSLPLPMMQAYPASLPSVRSLSLRSTSYEATTLEPCMSPLGSLLPNLTTLQLSRYWDRNHLERLLATTSRSLQTLSLPDCTERIDLSSVLTLFPLLEELRMVSATVLHNAIPRLLSSRVRVLALSGQVQVSLDTLADLIVRAGNSSLDRVHLDLLPDNIPLSRGLELRGYLDDRATVENVAVLAQQMRERFEPMWTTDLNPTSLTRLLNAAEVTGVRLTGQTATLLSWEDEYEASFEQALVEQAAGKDDYSVLKAYYGHERAMDAVRRHRPGQAQLWMPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCJ2</accession>
    <name>A0A2S5BCJ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_2477</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCJ2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCJ2"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="170"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="13">
        <location>
            <begin position="862"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1062"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1097"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1070"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1182"/>
            <end position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY74478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1195" mass="127870" checksum="5C6B005D4A0A3B94" modified="2018-07-18" version="1">MTTLAGGTAPTASVDPTAPTATRGGRGGRLSRRGRGRGRGRGGSTLALQSERGANEPVQANDDSATGTASSTRGNRNGRGGGRGRGGGPRSNNPPPQGDQEGTKRPAGRSRRAKFDATLSNGAAPLHAAALPYVPPSASTSGTSTPIPAPVNQTLVERLTAELSSSEAECSICADNISRTARIWSCTECSHPFHLACIGKWATSAVATSSERAHLLASRETRNPPDPSTLVGHWSCPNCNTTFTPAKIPKKYTCFCGRFTDPQPRPPAIPHSCGKTCAKPRPAGCRHACSLSCHPGPCPPCPVVLNEPCHCGKRTLGVRCSAVHDGKPDTPDRLAAKELLRSCGETHDRLLACGLHRCERDCHAGDCGDCETVRPKRCFCGREELEGICGATRLDERVESCTMPGQEAGEQWTGEFACYRTCDALFDCGQHHCQEPCHPHVAGSSPHCPFSPDSVSTCPCGQTPLSQLLPQPRATCADRIRTCAKTCSKPLPCGHACRTPCHDGPCPTCRESVPLICRCGSLKTTRLCGEPYRTDRFDEEAQAVIETDEFLCGRVCKAQRACGRHQCGRVCCPLAYQEALTAKKGKRRALTLQEALEEQELQDPLGLHTCDKVCGRKLNCGIHNCELRDHKGACPPCLRADFDELVCHCGSTVVLPPIPCNFVIDCRHPCIRPSDCGHPRLPHACHENPECPPCPYLTLKKCACGKRAVPNVRCSTDPKKVSCGAVCGKLLRCGWHRCRKSCHPPGECEEKDDQTCLKPRKHCGHPCPLPCHFPSSCPADVPCPKLIPVHCACGHLSQNARCGACDDKPEGNEGRLLKCNDSCAVAKRNAQLAEALGVEQREAKSKEVEYPPELLSYFAANSAWGQLIEQQLIDFVKSDKPSLHLPVMKRPQREFVHNLTDYYDLRSESLDEEPRRSVVCHRTSTTGTPTPTLAEALAASRKTASASLNLGSLRRALPERPTNNSLYLEMVLGYDEASLSDIIRPHARGLDFTLTWVTDEDVLVSFDPSVPDLESKISSICTALRHVIGETGFCVAVEAAVVGDDGRVARGSWTPVASSLASLNNGRGSGTSSAGSSKGAWRMPGIKTANSFASLGGGASGISPPKGAQASTESWGSVIGNGHAKPPRAVVAPQGEQERVVHAPAYPSSAVADPTRVPTPTLPPPPPVAKEQQDIPDAWDAVLEDEEPLPAEPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCM1</accession>
    <name>A0A2S5BCM1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCM1"/>
    <dbReference type="OrthoDB" id="2507336at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="553"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="961"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1464" mass="157564" checksum="C229ECD6C7A893E4" modified="2018-07-18" version="1">MVESPHPRSPTRSIRSDVVRSFTTSSETSASERIAASRAARALRRAPREADDSLAGETLEGEPSHATSTDALEGLATAEGTVTGGETATSSTSAVPRLRVQPTSDRSYSPSVPSSPAKSKKSTSASSHMSPTSLVRDDSSTEFPRAASTGNAASSGPSTPPPRSPSPSPPSSISLAGGLMERLKAQRAARAAQGAIAPDASDFSPTRAFETSSSRSMSVLGEDLMEAPAVLQATVTTFDNARPSSVPYEKLDMPPGSVAERPASLLERPSTLYGRVGEEIEFEFHQLSDVPEQTERSSLSTWQADKHSSWATSTAPVSPDKFPTRIKPFTRTEQSSSIEDDTSSASFRRNSALSSRSDRPDSFAQLASPTGATSTSPSADFLVDGPIRRLDATAHLTGRNASSASIFSAKSISSAASSTSERPASMLDHGSAVEGSQSGRSSPVRRLSPEVARRAALFGSVAAPMAPPAIDLHERRPTYHARCRTPTRGDPFSAPLEPVHPLPAPSHSSDEDLQEARPAPPAESGLSLLSRSSLARPAVPEKSGLRVGGGDSAIRCEGHLLLLGATEASPERRYCVLTDVGLDSRPTDQLPNVQRCTVLRLAECVRIDFEPAVSSDLLAFRPFALILRNGESRLFAADPPTDRLRWISAFRNLLSGRSPPFVARAESARSLTPPGSFFSETRGTVRSWPRAPAQVVPATTSRLPDRALVPSILPEIADGPGSHPSQVSPPPPLPPKPVQPPPVRATYLDRSDQFDRPSSFHDILTDENLASELRGLLAQLEVADLRKRGRHERYKRLRERLAALRGKLDTSPDVSTSARDADLAEKVDYLLAANERLLRNQELLQRSLGDRANALEANERELVRRVEDRLRDLIQSADRSSTLSPPLIRANEPDSWTVTTRRGGFSRSEQADWAADLRAFQHEAAEIGAVHSPLQGLSSVPSPTVVRKHREQASRKLEGIPSSSEPSRVPSASRLFGDEQVLAGPALAPATRDPFAGSGLVEPAARLPTSSTSQRSAHALTVLSFASSDVSRLEQTLSRILHSFEKQDGSLAQQRAHQERVSQVVGELARWVAEDRSIRDMQFQQLIQAVEGIVQHVSQLPTRLASAALDSPSAFSPPPRAPSVLSQTLQDLAATEGPYDDEPRVADGPTKQSKSGLLNPNSSFARAAEQATTRTTTRKDTTNTRGPRMPAFRLWGAPDPTGERAPHWGRPLPQKPTPDVEQTIETAAPGVVEALKSDEQLEQSLLAIARSAEGDMDPAAISMAVLEILSTMRDIARKQDAYEAKETAEKMGNTGLTDREAAELEVKRAEIARIEARTLMSEERTARINEMVAKLAERTEKADQLLKEIAQNVQEGKKTQIDPALSEEVKKLLTGVRAGVDDHVKDFRGQLTSEIQRMFKEVGKLRDEKVALQSDIAELLTFQAKHGGPSLSTSAAAPPFEVSIPPSLRPGMPTSGFFGPRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCN1</accession>
    <name>A0A2S5BCN1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_2251</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCN1"/>
    <dbReference type="STRING" id="741276.A0A2S5BCN1"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="73"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY74491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="496" mass="53392" checksum="4413DF7C3376836C" modified="2018-07-18" version="1">MCPTAASNGSTDPAPVPTTTGPVPAEFTAVDEHAPSQPEIEGHAANGSAANVTPIQRNPYGGAADFLSNVSNFKIIESTLREGEQFANAFFDTETKMKIAQALSDFGVEYIEITSPAASQQSYDDCKRICSMGLKSKILTHIRCHMDDARKAVETGVDGVDIVIGTSSFLRKYSHGKDITYIIKTAVEVIEFVKSKGIEVRFSSEDSFRSDLVDLLSIYRAVDKVGVNRVGIADTVGCANPRQVYELVRTLRGVVSCDIECHFHDDSGCAVANAFCALEAGATHIDTSVLGIGERNGITTLGGLIARMYVVNPEYVKSKYNLPALREVENLVAEAVQISVPFNNPITGFCAFTHKAGIHAKAILANPSTYEILKPEDFGMSRYIDIGSRLTGWNAVKSRAEQLELEMTDDEVKDVTNKIKAMADLRTQSMSDVDTILRVFHRGIKSGKLGLRQPAVFDALLAEHKSEAGSEAGDSDVDGPAKKKAKSTNGTAVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCR9</accession>
    <name>A0A2S5BCR9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCR9"/>
    <dbReference type="OrthoDB" id="10416602at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="77" mass="7996" checksum="DA1EFD32E34F85C8" modified="2018-07-18" version="1">MVYYACPNCGHRSDEYSDSMVHYNACTVVRERPGFKNTPDGRAATDPGPSQAGPGIGQSPPKTADPALAQAGGAKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCV4</accession>
    <name>A0A2S5BCV4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCV4"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1100"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1139"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1173"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1232"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1324"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="682"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1355"/>
            <end position="1388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1388" mass="155402" checksum="759E971A245E8DE8" modified="2018-07-18" version="1">MIYTDCHYLHRPGEMLLVLGRPGSGCSSLLKTLSAYTSSFRSIDGHITYDGIKPETIMKQHRGDACYLPEDDKHLAHLTVGETLTFASAARTPSASSRLGTRQETVERKRDTLMTLFGLRHTYNTKVGDDVVRGVSGGERKRVSIAELLTTGCKIGCHDNSTRGLDASTAVEYCKALRIATDLGRLTTCLSIYQAGEQLYELFDKTAVLMDGKCIYYGPQTEAVKYFRDMGYEPQDRQTSADFLVAVTDPKGRFPREGYEDRVPKTADDFVAYWKKSELCKANEREVDERLREHGEGGDGRVKTFQESAAAEHVKRQSNKSPYLISYPMMVRLAMKRRYRMQMNDLPTLAIVSIAALFQALIIGSVYYQMPKDTSGFFSRGGVIFFAILYNSFTGMAEITSSYSQRPVIVRQRNYAMLRPSADILALTLVDVPFKAITIIVFDIVLYFMSGLATSADQFFIFLLFTYVTNLAMLVFFRMLASMNRAEANATLMAGVGVLIIAIYVGYAIPRPAMRVWFRWLSYAQPVSFGFEALLTNEFRRLNVPCASLVPTGPAYAGINVANQVCTTVGSQPGQAIVNGLAYLEANNGYKWSHTWRNFGFIWAYFAFFLFVNLITYEYQKDEAAAGGVMLFRRGHAPPELVDAIEAPGKKGDAENGHEDARPQVDTAVNEKEKDHAADALERSTDIFTWQHVNYDVQIKSETRRLLNDVSGYVAPGKMTALMGESGAGKTTLLNVLAQRVDSGVVTGDFLVNAKPLPVSFQRQTGYCQQQDVHMATTTVREALQFSALLRQPRTVSKAEKLEFVEEIIKLLEMEPYAEALVGEVGMGLNVEQRKRLTIGVELVAKPALLIFLDEPTSGLDSQSSWSIMLLLRKLADHGQAILATIHQPSSELFQQFDRLLLLQKGGKTVYFGELGKNSQTMLEYFHARSDKHCGERDNPAECESERTITSREPFADRSSRTDILDVIGAGATAKTDKDWNELWKESDEAKKVHDEIEKFHSEKQGEASQADKSPDSKLSYAAPLWQQYVVVQRRAFSNYNRDVTCTQLAPQSVFGECEADILTWRTDVGSKIGLNVIAGLFIGFSFWKSPLDQTGLQNFLFAVFMGVVLAAPLSQQLQPKFLGLRQLFEARENASKMYSWPIFIITAIIVEIPFNIFAWTVGFPYTANRAGYAYFMFIVFEVYFPTFAQAVASFSPTAMAASVLFSSLFSFVIIFNGVVQPYAQLPYFWRSWMYHLTPFTYLIEGLVSNALAGRQLYCKQSQFQIVDPPAGEQCVNWLQSYTQSYGGYAQVLDNGNCGICPYSSGDQYLAQLNMSFSHRWRDLGFMFAYIAFNVAACFIGFYLYSVMDWSKLSRKKTKPTSKNPSQDNKVGDKENTNQIGGGFSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDB6</accession>
    <name>A0A2S5BDB6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDB6"/>
    <dbReference type="STRING" id="741276.A0A2S5BDB6"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129:SF2">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40067" checksum="DA5AAC59377EAB47" modified="2018-07-18" version="1">MLSSCFAAQLSPASLLSSLFSAASLRSMSTVQLSSSHAVDLLVLGAGWTGTFLLPHLRADHPDISFATTTRDGRDGSIRWQFDPELEGPEQFAGLPRAKTVVVVFPIKGEGGSRRLVRGYEEAVGARARWIQLGSTGIFDGGATLAALRVQAARSNDAEKQALPSSPPPFEWTTRHSPYDKTNARAVAEDELLSMHEETVVLNLSGLWGGSRDPINWLSRVAPTEEALEQKGSLHLVHGLDVARAIVAVHLAKTLPTSAALSAGSAARAIGNAEEEKRTGAGQRWVLTDLHIVDWWDLASAHPSTTSDQSEKVGTEPSPDRALWVARLMQKHDVRALPRSAAELGRAIDAREFWNAFGLAPVKARWEKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDF9</accession>
    <name>A0A2S5BDF9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDF9"/>
    <dbReference type="STRING" id="741276.A0A2S5BDF9"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="437"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="867"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="753"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1129"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="682"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1164"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1185"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1250" mass="136937" checksum="1FEC12772CF2313C" modified="2018-07-18" version="1">MTGQFVRALGTVYHLDCFRCMDCNKVVAAKFFPIDAPDGSGRQVPLCETDYFRRLNLLCSKCGQALRGSYITALDMKFHVEHFTCSVCPTVFGPQDSYYEHAGSVYCHFHYSTRFAVKCTGCRTAILKQFVEINRNSIDEHWHPECYMIHKFWNIKLAPTPPSKAIEATSETAADDSVEGDAGREDDATAYLAVEAKETPGSLKSRQKRMEEQVYRIWTILSAFEESSAACISEMLRHVSSGHYMEGVGMAEKFVLHVETLFAAIDDLNEAFRNAGAKEMQHVREARMLCKKIVNFFMLLSHTHETGARKMSITQDLLSLVTGLAHYLKILIRIALTGSLKLEREYDDRQAIGIFLSRLDRLARDPEANKISTTIIALARNGAPHSEVPRRQNSGQSATSGEDGPNASLGAARPAYGYKSLARAVGTLIGQGEATTDLCEGCRLTVEEECARLGTSIRWHLPCLRCATCQKLASRDPSADEISLADFVWASDGTESGRRTTYCRSCAPTPSQASEGIRDGFEYVTRLEQYAFLLCVALNKLFGRLKQKGVVPATQPTEEENSRGLTDIYGDSNDIKRMKSVQLDRKLSSTAAHVPKRSTVVQSPSGRTATSDATDSTFNLFQAKPPIPSRKDQPLIDPVSGMPVPRNQVREVLPSSQQATPTPSAGATPTQTPGLANGASNPFASSSQAPHSPASSPRRPPMDRRTTAVRIVDEPGALESRVEPDGLGGQREPTQDEDGLTLADLPKALEAEQRRAAGPDSFMRSGGNGGPFNGGPVGHTMQPNMAGPSTGPLGPRLLSELSALESFIVKHVAAVLLSSDSSPLREVVTLDELLDIIDARKNTFWGKLFKPGGGEKKKVPKKGVFGIPLEVLVERNGADSMHGAGPGSLRIPSFVDDVISAMKQMDMSIEGIFRKNGNIRRLKELTEALDRDASSVNLSDDNPVQLAALLKKFLRDLPDPLMCFKLFHLWIAAQRIEDATERSRIRHYICCLMPKAHRDTMEALFVFLKWVASFSHVDEETGSKMDLQNLATVISPNILYAKGKDPVRDESFLAARVVHELLERQDEYWEVRCRVRVPCLETRLTAMVIRQVPVECLSILNDQELLSNPAQLTTKEILLRAESHIRSAGAAGQMRVSRGHTGASRRPGLQEAWSAPHLTGSGRPLSTSVTPSRFRSPERDPRAQAPAGLPPLAGLAPSRTASPYQAGGLTIGTHDNGGRRGGSEGASPQTPFGDRSPVVPHPYQQAPREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDI6</accession>
    <name>A0A2S5BDI6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BDI6"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="3">
        <location>
            <begin position="2593"/>
            <end position="2666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="826"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1302"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1476"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1785"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1954"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2186"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2627"/>
            <end position="2664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="909"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="965"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1380"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1393"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1501"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1549"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1607"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1694"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1744"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1861"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1891"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1901"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1916"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1965"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2026"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2198"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2240"/>
            <end position="2251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2269"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2402"/>
            <end position="2412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2727" mass="288217" checksum="178579CFDEA91705" modified="2018-07-18" version="1">MASLDEFLSGIGVGSLSTVIELPATPDADAPTPGPAAKLHERILEEVTKTDDRTLALLKDQWSDFSEQIQTGDTLMKQLQSEEEELKALEDEMDGPDAFLPPLLSHLETQQSLAAAHLLTTTSVVLVSALLAFHSTVAALSEATTAGDLPKAVQELRSVSRAVEVGAEEWIEQTDLWKALIRWAADEEARLEGALQTAVEACFEIEVPTKDNGQTAQLVFRERVPAAPNGPELEVRTLLQGLEDLAAITGRKDQSDTILVRFAKQILRHFIAPFLEANGPRPGDTAFAKSRCEFVLDPTAPDTGISRMTLRPSSSSGDDAIEGLSKFLAFLADKSSLFPLSIDEVPSKQAAMLTAHLTPSLQSHVISSHLMPSLPASVTALDAYTSVLAKATAFEADFLPSHGLFAFLPASLRRDGHEVEEQRVIRSWAARVPHHWARHVGDSALARVRNSVKSWDWGAGEVVDVEVREEEEMLGLLLGLGLVDPEDEAAVAAAAAGDRSQLDALERSSEPSFDGKRRLPRELALQTVPKSAKREMTMEEALRPRVCRPRPPTPPERSLPLAQPEDAESEASKAAAIPGAPAKRNKLGATKISAPTYAESTVAPNELSPVDSDARERTASLGTPAVDGEPSAPEQADTAFPPASRVGSSSPHPATVQAESAAPTIAPHQIDEAAVVVPAASAGDSYAPFETPALTAAGIETTADAAPAEDVVRPHEYRAAVHDDVDAEEETSRQHTPLTEENLGQPRLDTALDATCEASTLESAMTEARTSDTFADAALETGSREAASPALSDPVKEESVEPELPDVEDDALGTTEEHAAFPAATATYAREQSVPISAADARLLEDGAGDSHPSTHEADGPSQLRSLFPEDQVNSPFAAYGSGSPITVEAGWSQGESSAQDATAPSQQSEAATVDSSSTVTASEADAAYFPIDDDPYADDSFAEDLYAYEPYPAPTHDDFFSPPAESPPPVSAFPPPVQPSSASSDPYAPPAVLSNSAEGSSCRTQPEQDAYMPLAATATVSPSAGSAVAPQPLFGSGMASAPPPPPRANASANSDATRTKPPKRRTLGYPALALDQPACPPSSANVVDPDRAAPDRYPSSQQSEAYPTAGLPARSLPQRSSTDSPKPNIAPLRSGFTTSNRSNRSGTPDRHNGLITNHIQQRFVSPPPTMLNPYVPMALPPSVAASPSSSYLPANDPLLAGLLGGGTSRTGSVFPFAGKSTAPSASKYTGAAPVEQVRMYGAQGAQSFVPAFEPETQHYTPPYVHHAQYGAQAHSQPAMRMRGGCSLEQMTMAPALRLRGGADLGDMDDDGSHSADDWGFGDDEIAPAADDMEDAWGFEAAPDETETPAPPIQTSPTSPPRSAPSHGSHAPRELKKPLAHAAHASTSSTNSQPPSMATSRPSSLIFSPSHVLPARSSLEIVDFDEGAVEGGDDAWGFDEEDAIDQIDQAQDTSPHTVAVSSADSTTASVEAAAEQVYPSAPSISRDADPGDAIAKRIVTPATSADAVSTQSHDGGPMTNGSDDAGDEWGFGEDRGNLALSLSGISDGSEPSAPSTTIASTSRTPATEASASEASETLGAVEDVGAVEAKTVPQALSEPEPLIGSPDNDEGDDDAWELEPPRADSPVASVLDEWEPDRPQANEGMGLQPRKAESIEMPLAPSGTHAGGHEAEPPAPADDPATSNSHGTDRMDDLATQAAAAEHAAPLPTEPATALTAPATDLEDATFPDARHQILPSGNAGPPSLTPTPPLPRPLPHSDDFAPGALQSPGHAHLLDYAAAQLEDAQLIDDGPQTAQSPALDADEANGHAELTDVENFAGDRRAAQQDMSVVDALIEDDSQAGAGVPPDTTDGVPVESFSADFDDFADFAEDQAEQQPRTVAWEPFEEPSGEPESTPASAEGYDRRNAFERDGLSAEPSELPESLSSTETPVEHFADLPLEVGSANRATTTVASGVLRPFDDESQSEATPSQLAHSSAATSGRAGQTTTTVRDAKPDPAEATAAGAEILEVHDENTAPGSTDDEESVVQHEDLRPWPRDDSAVQHESLRPVVTEAVAPGILLPAQEAHPQQRTFSPPPLSLPMEVYEAAEWDFDDDAVGSEVLADTEVVLEAADDPIREGQAEQHIPDRPLLVGDSEQTREGTVSAAATVEPQGHTFSPSAPALALAEHVDEKEAVTDSQALAVEDVPAEAASSFADEQQQQQVTSAVVAPAEEPAQAAAELTPEENEHDLAAEPSPGPAKGEHPHDDDSRETTTITAEAPPSPPTDNAADVDDPWDLDPMEPDDATAEVTADDPTALQADAVTEKPAADSESGPIVESTSTEADGFDLSQEVGKPSIPSDADDVKIAPQLLTSRSPDAVRAVSPPSSIPEPLSPRPTAKTPGATLDSWQWDDEEASPPSEPPEPRGSAKPEAEDPAPDAPSILTERQLPTVRREKMMVSRQSREIVAMAEEILSTAFQIASPSFVLPQFGPASAPLLRHFVSILSLYRATASVHNSNLLASVPAIAMQFANDAEWIGREGNRLWDAAVAQHADQVSQDQRRDVELAIQSMRQLGRDTRQRQISIQQAALMESLDEAGGFLRTSDETRFSACERALQQVTHILQRLALVWKPIMTPTALYTALGGLVNEVLLRVLDEIEEQTDISEEESNRLNRLSKMLHELEGLFDGSETNADFMFLFDNRFLLDFTPQELVRLLRALFADSPQRDAAVKRILQGHPDAPADAEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDI9</accession>
    <name>A0A2S5BDI9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Responds to activation by environmental stress by phosphorylating downstream targets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDI9"/>
    <dbReference type="STRING" id="741276.A0A2S5BDI9"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="359" mass="40915" checksum="7857634F5E07AFC7" modified="2018-07-18" version="1">MAAPDRKFEVGNDYKIVDVIGEGAYGVVCSAIHAPTQSKVAIKRITPFDHSMFCLRTLREIKLLRWFNHENIISILDIVKPASLESFSEVYLIQAHLIFVPVQELMETDLHRVIRSQELSDDHCQYFLYQTLRGLKALHSAAVLHRDLKPSNLLLNANCDLKICDFGLARSAMSSETEAVGFMTEYVATRWYRAPEIMLTFKEYTFAIDVWSVGCILAEMLNGKPLFPGRDYHHQLTLILGILGTPSLQDFYAIGSQRSRDYLRALPYQEKKPFQTLYPNANPLAIDLLERCLTFNPAKRISVVDALSHPYLEPYHDPTDEPTAPVLPPSFFAFDQQQLSREQLKVLIHDEITAPPPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDK9</accession>
    <name>A0A2S5BDK9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_2139</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDK9"/>
    <dbReference type="STRING" id="741276.A0A2S5BDK9"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="417"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="295"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY74866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="627" mass="70735" checksum="55E7B5A90499B8C3" modified="2018-07-18" version="1">MLDCQLEKADAAHASAAADPPAPAPKQKRERVRIMGIRQHLEVQRVRQQEKQDPDNWFTRKFIIGIVAGVFGYSYYVYVVRLCIPMIRMRDNRLGGRLSSVLSATKRPLMDKRHRPAVVYLVIYHLLFIMFVWTYLVAVATPPGFARDVSKDALALVQEASADTHVELQYVPETDSPQAEEQYITVAGQAFEDQLQPIQPKLAPADLYHDPNRRRHTSRRSSDSDASIADIVGGDVDAPATEMRQTNTRVVLSSTAQQEEEFAEKLPTAGVFGPAIGAAVSSAVLPSHTATLDATAPIPLGEERSQSTASTAVEPPASTISSPAKAHTRPDTADLRDGTDLARTTSQHSYLHFPDPPPELEPPRRLAVERIPRSAPVLTEQYRYDPRERIVRPYRMRLTGQIVLPSIAKAELGGELAEMDHHCPWVGSCVGARNYKYCASPFDKVYNFLQWATAYLFFVFLTLVIAQTLPLGTFTAARPYPGVDGQQIAVIALSFFFLFFTSSLLSQHTGLILRNMTTIEQIGLARMRQRERAALTSEYGFWGFKAKRDTRREWDKQWGRPSQEGNLWWLGSKRANWEMVFGQEKLGWFLPIPARPSMDDGLHYVPNPRFSPEGYWRERRFWPAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDL8</accession>
    <name>A0A2S5BDL8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDL8"/>
    <dbReference type="OrthoDB" id="2529080at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="798"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117931" checksum="43371C4720CEF3C2" modified="2018-07-18" version="1">MQLTLVPPDAYPIPPAFHAHELKPPSFRPRKSVKSPELWTRTRQQLAEVGIRVPDPLAGDLAAWWSYAVSAVEWNLELEEVIVTLADGTRERWDLQPSDRVRSTSVIEDSEMEDVDGPTEPMMASSSPLESDPTADRPSSSRWHADAVSARLRSFALQLRSAYEDLGTATVSDPVAPDISTETDYRLLMLLAAEPSRQIPFEWSDAQIMYEYAMMGVDGNTEEGPEAETTREGRMPAWRRELRRPSQGRRRDADDPDDFDPAKFTGQFRSKRRPAGRKDSNGRPIEAYTYLAVIDLLTQIRSYLCDLFAATVIPQLRDRLPPSYTLWATDSAIVWVRREAIKRARDAADLIVELLDDDGDRFDSSECSSSCRSSPMQIDADDRSHPFDIIVDMDEAEGMLDGSQGMDEWQAEEHRQQRLADNPLRLLRDDYELRKWCIDMSDRARMLDLVEDDTTAIRSPDWIKRVPSFEVSSLDGAQSSDSDMPGIGRSVRRKTLFSSRSRIVETPSSSPPPGVNRDRSASPDVPGLTHSDTETEPSSEVDELSEEDIAVGSTLLARDFFYPDDPLGEGFLPRRLPLELVDKKSKGGAELQEHRELLHSVLNEVAGLQKRLVALHELVKEETKTWEEERAQSVASPDSKASLVRVKMGRTISHPPPGPVRRRHPPRPGAPLLKQSCDRALGQALDEAYRQSDSPSMPKHVRQGKLTAAAQELPRKRQRHNLETYGRLMAMSNHILRDEPEVPIPAFMQQRKRVSNGPGFRRKRKNGGAAEGSIRPAKRVKRHRQQDNSGTEADEQTPSAASARPRVSPSPDQRHLAAAGLSARRRRVLEALSNDSGLGSMPFDSAFGAGDEGDDDDDESGTDSLDAPPPAYDSALDWGDELDELEEVVVGPVTQQEELPVEEDQTRPRQQRASDSIRRSGEPLDGFDYFEAPTRFGSPIPYSRPHISPLVEPAALPIDSAGSATHSLLAAQPAYPLSAARLESDATPSTIGAESTPAVQLGSLKSTIRNAAQAAEGEAANSPQPFESTPSLFVNLPSDVTAQLEAQCDQRSEADGHPSGLSDEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE89</accession>
    <name>A0A2S5BE89_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE89"/>
    <dbReference type="STRING" id="741276.A0A2S5BE89"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="256"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="340" mass="35693" checksum="992B15F0F16F14DD" modified="2018-07-18" version="1">MAPPRSAVAQKLRDQDPTLLPSEDEDDDSDFALSDSELAPTRDAGSSSSSSSSSSSGESDTEQPGNKAKKPAQKKRKRTAKRNRVADEEPVAAAPAAPVVDVDDLWAQFNAQDDDPYASTSTSALAPAASTTGNVNGNAKGKAKADNQDQDDFVTIQVEYEFAGEKVQQQKKVKRSSAEAQAYFARNPAAARTSAPTPPPPPPPKKDLTSASLDALFGPEDPSSNPPGPSSAAIAAAVPTTSTPAAPAPKRRKVGGGRGGGLAGVAASLGVGPGGKPAKLNTLEKSKLDWTSYVSSETGLEDTLAHARKDGYLDRRDFLDRVDQSKEEQWDKARQAGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEF0</accession>
    <name>A0A2S5BEF0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEF0"/>
    <dbReference type="OrthoDB" id="10563288at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="147" mass="14853" checksum="12C058FCBA8E53A1" modified="2018-07-18" version="1">MTSVPTTPPSSSGAASPTSSYYTPAFGWTGRSVTVSSTASEGPSNIPGSSIAASKAAASAASAAASSAAGAAKSSGPNFGLALGLGLGLGLLLLLGLFAGMYVIRQRRIERLTFAKRASRIKETMRTVEERPGGLESPSLQRTSPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEF1</accession>
    <name>A0A2S5BEF1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1784</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BEF1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20024">
        <property type="entry name" value="FH_FOXJ2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="366"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="955"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1134"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1201"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="851"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="957"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="970"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1152"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1291"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1324"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1344"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1355"/>
            <end position="1366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1366" mass="137966" checksum="734459DB28886D5F" modified="2018-07-18" version="1">MLGSPPSAAAALPSFSFLDDDSAHRVASDTDFLPAWSTTLSPSPKLTPTIPSASTSSSAAAATTGLNAFATSSHSTKRAGVRASESSKGKHRAPDVGTGLSPVLGPTHLGPTALALDVAEADLGEAVFSPIAGRSAFESSFSQYAKPASTDSPATRRSPIMRRKRLSNATADDAPAPLSAANVATLTSLPGASASGSQSRRASTSVQNPSRRQSLTEDALGQRAYAQALPEGLQRRSTAVSSPGEEAPQIQAYAKLEFPSFDIYIQKLSVTIGRRPASAMVNLPSPSVPLSLDDAREAGISLEDYILGLSDNPSIKKEESLTPHELNGLSPKGLDKGKGKAREVDPFADLAHSLAGEQKPIVPADLLAGTSTAAGPALAVPSVTAVLPPLTDVDLGPLRAVSRQHAKLYFDYELGAWVLEVLGRNGVVIEGKWRARGQKAVLTKKTKIQIAERIFHFVLPTIGVTTATAANEVESSTKTKVQKGKGKGKAKAAAAAAAGPPKEDDAASSSSLSEVSDSDVEVTVTRPPPPTKKKSGSRDLSATPAASTVSLPTGPPTTVDPGLLTGTKPTPSAAPNSSATQPRKAPPAAATAASYRPVRASAKRPPPASPASKASPIPAAPTIEPAKGEIEDPKARAEMVAQILSSRVPAGTGQTKLVKAAAEAQRRAGKGKSKAPPRAAGKAPGKGKGLPPRSRRPSDASQWSDQDLAMGGSSDDSSGDSDVDEDLVQAAAEVIGTDGVKNRAGGGKMLSSVQKSASASPAPPPPPHVPAKTPRHAGKMPMKQPRQRPPQARSPAVSAANLPTSNSVHASLPSILPALPALAPSPAPGTPSLLPPSALPPLPPLKPASPSPAVTAAPLPMVGGKAPKSAAAMALAAANQAAGAAPVPAKKPKSHKKKVKADAATPGTAPSAVAKPPPTSAATNGAVPAIAVNGVAGAGDVKSVVPDIVVNADDSATAKPGPAGDAAAPAPAPPPKPRPSPYTPAPLAADAIPPDHAPADDPTAKPPYTYASLIAQAIHTSEKKKLTLHEIYDWVKLKWPYFAVSQSGWQNSVRHNLTPARGFLKIERREDEPGKGAFWEIDPAQMAAFDGHHYRRKPDGPTGGSSSNKAKAAAAAAAAAAAAAAAAAGGSTDAAKPAAPVVKPSPTPAPATPAAGASAAPSPAAVARPPGSSAAPGAKPAAGPNGAILSKPLPLIIGPIPASYVRPPPPPTANGQPPDELTAQLLADPPIVMHEGQLILNPSIFATLPKATLDALQKQPAGKALPVLQAHVVQHLKEQLRKKGMPKSNRPPTSSTPPAVAPAKAPNAGGTKRARESEGGPGDAATSTLKAAPAAKSAKHKKGTSATTASTTAAAPPPLQVTPQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BES4</accession>
    <name>A0A2S5BES4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BES4"/>
    <dbReference type="STRING" id="741276.A0A2S5BES4"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01167">
        <property type="entry name" value="LPXTG_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="55711" checksum="E44C391270A61D7A" modified="2018-07-18" version="1">MDDFGKEDKAIVAAAVQPVLVSEDNEREEERLAALGYKQEFAREFTNLSTISFAFSIMGVASSVATTIDTPLLLGGPVSVVWCWFIGSFMCMCLGLSIAELISAYPTNGGLYSASAYLVPRAWRPVTGWTIGWLNILGQVAGVASTEWGLANMILAAASISTDGAYVATAGQTMAVYVALLVVHGLLNSVGTKVISSITRIFVFVNLGTVIAVVIALGVTCKDKHPASYVFTETVNQSGWPSNGFSVLLGLLSVCWTMTDYDATAHISEEVKKASIRAPVAIIIAVAGTGIFGWVYNIMFVLCSGPLQDLPGAAGYSAATIILRNVGLKGFYVLWTAVCFVAFAVVSTALQANARTVHAFSRDGGLPDRGFFCKVASNRVPINAVWIVCFVSALLGLLRFASEVAVNAVFSLCAIALDSSYAVPIACKLIFRHHPEVNFQPGPFALRGPLGTIIPSVAVVWVTFTVVVLAWPESLPITAETWNYSSTILGGVLLLTSIGYLLGGRRRYSGPRTAFEVLEGSMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEZ7</accession>
    <name>A0A2S5BEZ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEZ7"/>
    <dbReference type="STRING" id="741276.A0A2S5BEZ7"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="365"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="424" mass="45233" checksum="B6D2400AE428537D" modified="2018-07-18" version="1">MPARDRVVLPATAHLPAQTSQQQQQQYHPNPPPTSASAAPHGHTHATHAQQPQSNAQADALSVILVTGSYDGTIRYWEAWSGICSRTIQTQDHQPNRLAISPDKRFLAAAGVGTVKLYDVAQSAAASSTNVAPLVTLTGHTANVTSLAWQNEAKWLVSGSEDGTVKIWDIRTSSPQRNYAHLASVNDLALHSNQGELISCDQNGAIKVWDLGGDRCSHELLPEEDVPMRSVSIASDGSALVGGNHKGVVYVWTIQPGLAFTDLQPKTRFQAHSRYLIRVLVSPDTKQLATCSADTTIKIWTPVLPSSTSATSSASPSPQFPPSTSSPTSFDPSTQATDPNAPGALGGYARGGIADGTGFQLDKVLQGHQRWVWDMAYSADSAYLVSASSDHTARLWELSSGTTVRQYSAHHKACVCVALNDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF46</accession>
    <name>A0A2S5BF46_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF46"/>
    <dbReference type="STRING" id="741276.A0A2S5BF46"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052969">
        <property type="entry name" value="Thr-specific_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763">
        <property type="entry name" value="ALPHA-PROTEIN KINASE VWKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763:SF1">
        <property type="entry name" value="DUF659 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47325" checksum="37F9BC8906911BA9" modified="2018-07-18" version="1" fragment="single">FLAPPPSRASGRIFQHPLAPAHRPSYDPSRYTRAHRREQSATKNIEVICENIVHSGSLPSADCLRIGLVAYRDYPPQDNSYVTKSFPFTSSVPTMKEQLKSLYASGGGDGPEAVTAGIKAALELDWRPHATKMCVLIADAPCHGIGEYGDGFPQGGPDGEDPLILTRQMAAAGIPLFVVACEPALSGYQFGLDIFNAFTVITSALLVPLTTASLLSHVIVGSALEHLEMERLIHEVGQAVAERIHAGLQTVDDVARELHERLLLRGEETKQLKFESIHRETEESRHNVEVFVNAPDLQAAKPQLKKIRGSRFTEKYLQSRYNSSYSRSFGSTPDIIYPSLPPRPGGLAASTAAASKLSTSPRRKVISEFKPFSASGLSVADAPLGIANAPNSAPAEMADDEVEKLAQSVELRFAGISLEQAKRITIASAWRTAPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF94</accession>
    <name>A0A2S5BF94_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF94"/>
    <dbReference type="STRING" id="741276.A0A2S5BF94"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="277"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="414"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="50844" checksum="C554CAB6E29F595F" modified="2018-07-18" version="1">MASEQEQLAQFAALTGASLNQAQFYLDANNKDLNAAVASYFDNPAGGSTAGNDDNDDPSTAAGASAGQSTPSNRPTQSSGAVGGGRGAYTLSGAPVEPMPAGWGAATGSGSNSGRNSGASTPNRNPIRSSGGPRVTGFRDLAAASAGPSSGGGGFGGFGGGGDDSDDEDGRKDPQNFYTGGAKSGLSVENPDDPRRRGGISDMLKNILQQAREGSSRLAGGEEPAAGPSFFTGSAHTLGSDETPSTYIPDPTRGPSASGPAGGAAGEDDEEEEEEEVAVRNLTFWEDGFSIEDGDLMKYDENKELLEAIQSGRAPISVLRVKHDQPVELRIAERRHERWTRQPPPPQGPFAGSGNRLGAGSPFPESRTGAGANASAGSMPGSLPPAVIGSSSAASSGAGGNSAASTNVEFEVDRNEPTTQVQIRLRTGDRMVATFNHTHTVGDIRRYIERSRPGETQQSYVLQTTFPTRELTDLNETIKQAGLLGSVVVQRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFL5</accession>
    <name>A0A2S5BFL5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFL5"/>
    <dbReference type="STRING" id="741276.A0A2S5BFL5"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015658832" description="Protein CPL1-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="3">
        <location>
            <begin position="505"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="606" mass="61883" checksum="88F0B550230D685D" modified="2018-07-18" version="1">MRSFFVSLVALACASLTSAQGATPIGHGTSASTNDQSPVSPVVDTPSLDKRLLCLDVGILCLGLGSDGIPGNVNNCGRCCNRCPTKWANGGGAQCVEGVCLPSQCDKGFTLNPRTQACVNLQNGDTANWSVRTVYKKDSGALDKVCAVPGAKGQSCVSGQCQATACQTGLTLSSTGACIDLNTSIDNCGALNKPCAVSGATGQSCISGQCKATACQTGLTLSSTGACIDLNTSIDNCGALNKPCAVSGATGQSCVSGQCKATACQTGLTLSSTGACIDLNASIDNCGALNKPCAVSGATSQYCSNAKCYAYACSPGLTLSPGGACLDLSQDTSHWCTPRRDLMKTDRRVTFHRSGAIDVACSATYANGGTGSCINGHCFATCDFGYAFDTKYNFCRPILQDLLNCGLIGRQCSIAHASKQACIGGICLAQVCVSGYTPSLDAKVCVLGASGRARAKRAEQTPQKTLCPAGETACPIAGSSSFHSVKARLSSTDLGALELLSAADECLDPKTSLESCGGCASTGEGQDCTTILHAGSVGCDAGKCVVLSCAGGYKPSPGGDRCVRRRRARQIGTATDRNVTSRFNHGRHGSHHHRRHSHQAGLGAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFM4</accession>
    <name>A0A2S5BFM4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFM4"/>
    <dbReference type="STRING" id="741276.A0A2S5BFM4"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="21"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="589" mass="67667" checksum="51244E222DD3B0C6" modified="2018-07-18" version="1">MALEANKRLPSWWKDGVVVYQVYPASFKDDNGDGLGDLRGLINKLPYLKSLGIDAIWLGPHYKSPRVDEGYDISDYKDIHEPFGTLQDCQELIDKAHSHGLKIMFDLVVNHCSTEHAWFQESRKDESNPKRDWFYWRPARYDADGVRHPPNNWRAAFGGSVWGWDEATEEYYLHIFDVTQADLNWENPEVRQAIYKDAIRFWLDRGLDGFRIDTANLYSKRIDFPDAPITAPETPWQPASDLICNGPRLHEFLREMRRETFDHYDCFTIGELPNAPQLSQVLSYISTDAEALDCTILFDHMYLDHQDGQFPLMLTPWKLSDFKRLAAFSQELAEPENKAHALSYLENHDHARSVSRFASDGPEHRVASAKMLATYLLTLSGSLIIYEGEEIGMINAPKDWDIDAEYKDVCTVNTWREIKSEAGKTKDQTLLQRGREGIQHCARDHSRTPMQWDSSPNAGFSTNGYAKPWMRVMESYKEGINVAAQEDDPESPLNFYRRMLALRKEHKDVFVLGKFDLFDEENEQTMVYTKTSRDGSRVALVALNFTSEPQAFDVPSSLEKKSTGKLLLCTQGDGADGQLRPYEARVLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFM9</accession>
    <name>A0A2S5BFM9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
            <topology evidence="1 7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFM9"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="78" mass="8695" checksum="D1B506799DB55EC2" modified="2018-07-18" version="1">MSMQRFTSVSVRAVKGRQPSFVSQRAMHVENRVNNNFPFRYEGESKTRFTVGFVSVATIGFSAPFLACAFQLKKAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFU8</accession>
    <name>A0A2S5BFU8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFU8"/>
    <dbReference type="STRING" id="741276.A0A2S5BFU8"/>
    <dbReference type="OrthoDB" id="2568455at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="605" mass="64179" checksum="37C66469A9655B4B" modified="2018-07-18" version="1">MDDATVRPSNPLERAISSQPPPLPTSEPAAPPSALAPTPTRRAKPTATTTTASRLSFDYHQGRAAAQGRRGPSSPSPSPTMTRLPRSPASPTMAGAAPWRSPPQSPTLPHSPNSFSSPSVRPPASRRNSSSPTLVRGSGGGGGGGGHPHAQSIREQPREEDLEKFEDLCRRLYYDKDPTAARQVDQTLAKLPAGFRTTYARAMATIRTAFHRDEEIRRRREVEQILATCEPAATIKAAIGVSPHSDSVPAMRSAAARQARGHRLKAFVQANCVEAMPGTHPFFRGLFAALWVQANQAEARCVEWEVDVAVFTEAGSGDAWARDAVEILKGALGMSERIKSQAASTYADSTRTSRLSSARSETSSVRHSQPVMSSATTAPVVFERPAKKTSGPPPPVPPHRGSSARHRAPSDPFLDNKAPQSDVGLHAADEAGRVAIGSTPSSTSLLPLPSPISPLAYDGGLSSPTASTPFLLSTHAPASLPTTPLARSPLGSTSHRPIPTPAVAPEFRVFTLPPYLTNPELHELLRLFPSFIGAPVRRAAASAITTHELETKVSAVVHGDVSNGSAGGGGGGGASESAQYMRNAGWKGTLWQRFVLWLMRLFRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFV9</accession>
    <name>A0A2S5BFV9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BFV9"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mmc1 C-terminal" evidence="5">
        <location>
            <begin position="380"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="651"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="7">
        <location>
            <begin position="1354"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="8">
        <location>
            <begin position="1713"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="9">
        <location>
            <begin position="1862"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="859"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1997" mass="214847" checksum="844C6B687B653174" modified="2018-07-18" version="1">MLSRAARDVRSRARRSLATVSSQSATAGSPPLHASADTATLLDELQALLRGYPLLEQAWPDRIRLARAKWSDPTLPASIAVVGERDSGVTQLVSTLLDDPLASDDRVALTLESRRLNSKAPETIVIRYGPEGKVEAGSVAVPSTWLDDIKAELVEIQHGGVVPLESSFSALHLSDLVILVLSDSTLLSSKAAQTTLYNLASKPNVLVALNCQDASPSASSSALRSLEHQLETLLPPSTAQDGIAPRPIVISTRQATDALEALTPTEPAHQPSYETFQKGYLDSQIPQLHQLLTAAVSETGPRSVLTGQVSPLQQQTAAYMLSTALHRAAFAGATVADAVDSAAASLSALKQHTDEARLALMRDLGVDDAETGLVRVPADELRHAMAALDDVLLKRLAWYKLPYRVDDMHAEIALVVEKTYLPRFEDALVFASGRAVATADELSAKTDKVLASPAFAESPSAGALSPATKLASLHSATMLNEIAQASREAAHSLSSAPTALSSAVTRRRNQITAPGGPTDALQRRAQKAVVSSATWSLVSAGGAIASELTHYAELGTNVGVGLLGVTLGAWGLQRGWEKAKKRFRKDVGERITGGLEEDLGVRAHKIAERAAWKSTEAVRLGEEAIRSRTEEWERARRVLADLEQRRRRGLEPAKLQVLVVPVQPIRRRVFDRHVETLNRYSAVPLTDVPPDRRGDRAVFSATPNAAGSLLFDFVTPSAYAASRPLAFLADLQTHRRVQGIIGILDASEYTSHSLDDALASFQASLKALPKTFATKVYGFGANEGQLEQARAVKESEGLVMVPSEGDVGFFLKTILAEFASGILWEFSNTAAQLESRTSIPTPQEHDSLSLQRAVSRASVESGRSYHVPDRGTPPLQHSSVMNRTGVAAPPQSHPHTVPNGVSTAPKRDSLAFGTASLSSSPKPILPSTSAASGVATTAQLVDARARRRVAGREKKLMGDMWLLSGRPQEAIMAYNEAILLTKAWSDQVWQASAYEGVAVALVLQATQPRGSQGTQPPSLGQQRSDSPIPSAPIPHSSTFLSAIPERLTLAVTLYEKMLAPITPSRDSAGSLDPDRAHPLLYIEACLRSAKFLLAVHEAQGSMPKALQRLVLPPQAKDSQMSSAEQARQARLNSLVPSNTVPRSSIAIWLNSAYSSHLQSLDPPVRIRALSEIAALYARVGYRRKEAFVLREIAALCADAAVQQMVGDASLGSPRGKPFSPKIPVINEANGTERAGGQRARVDSTALVSVLGKVCEAVGLGAALEALASAGDVARVFGWPAVQLGILKDAALMAEAVQDHRAAIGFIVQALRSLAATIPPFEQYDLSASIPRITAAASMTGATLELDYWGPNELVMSLEVAPLASSRQPFEVNQSVVGAGAVGELPVKQNPFLYDPRQQSKASTGSQALLLQGEAAEIYVTLRNYFLFELEIKSMSLSTEGAAFASESTSVSIPPNSLQTLAGCTTREFTVVREASGGNDARLSPVDSLRERIKKTGLDAAPTRASGSTPSNVAEPATEPEFIECIVVPEQPLLWMRSTSLTHGALMLYDGEISTIRLALENASSTPVDFLRVTCSDSLTEATRAYLADAELDAAEVYELEADVVERPVFRWSGDPETDIAAGQSHMLEVECRGKIGCMSGSIQVEYGNRGSGIRDGAGKIWTRRLTCDVLLTVHQTLVAHSLSISHLKSSKGAVRSHARSASVVSLGQRGAAVDSRLEDSLRGVEAGEHCLVSLHVTNVCGKPFEVKLERREEENDFYLKRKRAEPGSTHRLLVRLDRLLLSDEELARPIPSLSERQFIAAKVKRSASDERLERELFWYREALLRRIRLSWNEVGSLRTGDIGLQGVRLDSAMLEVLRQDEVRIELSLAGESAEQTGDRPHSAYSAVADDFLEVEATVTSSSATALPLRLRLELLPPNAESAAASLSHLARYVVIEGITPISLDLLPPGQSTHAIIPLCLLAQGRYDFGCIVEERTEGLRKPRSWRSRTTLTIQVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG19</accession>
    <name>A0A2S5BG19_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG19"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="571" mass="61364" checksum="2C0459D161EE3F6F" modified="2018-07-18" version="1">MALLKLPAKKPKGKGKQLHIDYTTLESARATAPSDWSAEEWLEDGTRQEEQGERYQVGLKAARHLANATTCYRLAATLSPSSFDARYNAARVMQTLGAGHLGPPDCLEALEAARTGYREALAVLQPGQAGEATARIDALYNLAQADASLFAQLENGICVVQDELDRKRGLAQEAKELFAEVERLQRVELERYIGSGASSNGAEEDDDLDVDASADSATETSVQVTETTVVTPRLVLDTLLAAIDFDIQLSDSSLADPGTDAQVRQSAVAAFSRASDLRDVIAAQEGGPAADLELDLALQQAEIFATWSPEEARPRLESLVAAPEATPRLIDVLSMHADFLVENLPLSDHASALSSLEAALAAYQRAATLLSSRLSPPKNIPAQQLPTLLSANLASQAHVHLLAHLLDPPADFRSRKHADEAQRLALEAISAAKPAVWLKVAGPFSSTAPETLPAVSAVRGANAQDARSDWATIAAVRHAFFTLVRARYWAVASSGPSTTAELRDQLRARLWSEWKVLGLAGPSREGATGVDALRRRELEWWAGEIEEDLVAKVVGADEAASERQWYAALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGI4</accession>
    <name>A0A2S5BGI4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGI4"/>
    <dbReference type="STRING" id="741276.A0A2S5BGI4"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF145">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015376080" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="50"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="553" mass="61580" checksum="1A1755E4AF2A5335" modified="2018-07-18" version="1">MLSKLLQLVAITAAVSQILADDMAGTSVGNYKDIGNGVHVPGAIPNNKWEPLQHRLAYAGPTGMSVSWNTFAQIDEPTVWYGLHPQKLDMYVKSNTSITYPTSRTWNNHVKVTGLKPDTTYYYRVSGTNGAGAAYLPTYKFKTARPAGDDKPLTIATFGDLGLMGRDGLSTKTGPIGGDNYTDIGEYDSNTIQSLLQSKDTYDFMYHVGDIGYADYFLKESVQGYFGISDNATMPTIDEVANGYESLSEQFFDQMVPITAEKPWMVLAGNHEANCDNGGVKDKQHNKTYTADYCLPAQQNFTWYNHHFAMPSAESGGVSNMWYSYEVGPVHFVSLLTETDLGAGNPGPIENVKGNMNGPFGKPNQQIDWLKADLASVDRKKTPWLVVGLHRPWYTSIQIPEIYTAWQKAFEQIFYDYNVDLYLTGHVHTFESFKPMFNGTIDAAGFNNPRMPWPIVQGAAGHYDGLDQYDGPERLNGSDYSNDQVYGWGKMTFHNKTHVTYDYVASRNSSVVFSQTLYKEHNFGAANCTDGQKILPKMQKKPPKVNARASIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGJ2</accession>
    <name>A0A2S5BGJ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGJ2"/>
    <dbReference type="STRING" id="741276.A0A2S5BGJ2"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="123" mass="14529" checksum="E81D7E9A035330D4" modified="2018-07-18" version="1">MDRLTEYLEETIEAFDDQPYDVEYSGRNVRLTRYKPSMCGKSGVLTVRLGDNGTYVLNKQPPNKQIWLSSPISGPKRYDWDSTHHVWFYHRDGDLLHDLLNRELREVLRDETIQVDLAERDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGL8</accession>
    <name>A0A2S5BGL8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGL8"/>
    <dbReference type="STRING" id="741276.A0A2S5BGL8"/>
    <dbReference type="OrthoDB" id="2530238at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44238" checksum="EF3BF4F1FA1BA170" modified="2018-07-18" version="1">MSSDNLQPDRLTQGLPVELFTKIVELAQAHPQCAYLGLVSRAFLPLARHHRFRKTTIHSYDKLESLCTLSQTHEFVHSIKELTIDFEGVKDPGTPKKADFHALLKRLYHVETFKVKASGRLAKEILDPKSNLRASKPPLGTIPLPAMQALEIDDPFQGWANPFDPRHYSSLKHYRSLDSLSLKIVRAPDSIGRYRSAPVSQLSAARGFAWSVALTGYLADQPAVRDLLHAFDEIAILDLIDLGTAEGDVFGPLLSSIRYLDVLKVLDLQRSHRPPTLLPALGHLPVLKSVLFRVGANPSDADLRCLLEGPDKPPKLEFVGINCAEILMYNEWEGIVTCPWSTTCTYAGTLKNMELAERVGIDLGGSLITYAKDERWFYEAVGRGEILLYDEEDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGP2</accession>
    <name>A0A2S5BGP2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BGP2"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="840"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="888"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="918"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1319" mass="138911" checksum="C33CFF285C0B76A0" modified="2018-07-18" version="1">MPLSRPVSSADLRIDNGSLPPAPSPSGHHAETASGRVALKIGLERQCYVAGQQIRGVLEVHAKSKGLALGDIGIEFGGTEELRTRDHTSTRRLLNTRIDFQGNGLPPSNAVVPNSRPVQAGFYPALPGRTRFPFVFDIPAEAPSSSALGSNATKRFELRAFASSFSDANVDIRTEKVEVKVVERWADWKEGPWQLGAEKRAAEKLAVGGDGLLVMSVSIGRGDDAEKPARLFWRGDADLELDGKGTIEIVANVRNLTKRHVTGFKVSLLRRLRILYPEDARPLVEPPIVTDTVASERFQGIDFDVRAECERSLVLPMHVPKDESWTVRRGSLFELDLVVRVEAECGFLQKPLAVDLPIWIAHPLSLPNSAHRFAANERARLAPIPLASPPESGPAPNFTPASLYVAPSPAPSTISTYLPLPGTPQPVSYAGSYAGSSVSMVSSVSSPAGWPPQSPVPYFPPPPAAPAELYDPLSTAWAAPQSSPVHSHYPLGGGSGFQLPPTQHYAYDTPQSSIDYSASLPQAYSPAPQLSAPSTIPSPRANAWVPSASTVNPPQLTSSLPSPSLHGLSQYSPPLPCPSPMPAQRPLPPTTPSTPPASGGPRSRTPRRTPPPPSPSTAYRPSPSTSPAPVELADPARPASALEVPASLETIGEDGESQAGTAKSAALPSGAADELRKISAEDGEESRQDVRPSVGSRRTSAQNLEDMVDDEERARQAAVSSQSTGAIPAPVADKALSAASRGRLRAQDIFSLAAGDATDPSSIAAPAKPSDPGRHASPSPPKREAGGLAALQARLARSTSSAPGRELPAASAGSRSPSPTKMLLDVVPSPGPEFRRARSISRASRYQQSASTATQEDPRGVVQRIRAQSGLSPINLADLRQLNLFDVPHSGPSANSSPSSDSPCAVNAVSLEETRPTARLPLSSPRRALPSPEQLETVGDRVSVQAGAVGPSAITRRMSQEVQEVSRSGVSATSADPPRRPVFSSQPSTPAAPSPTADAKPAGPSPWSSRAASPWSPRATVRPSSSPVGLTEPRDSTLSKAPSSPIADASIDSTGRKVVNARELKDLKQIAVERVAGWISGTEDAGDAPYVGPVDQSSQPLVRPDTGSPATSAALLTADSPQPAIFRRSLATGSHSMEPPTPTQRLAIETRAALRESQRIRPVSMSAASSVQKGLNSYLAALEQDASFERGEQTHKSVKIAKPGKVTSVASIWAERIQHSDLDTSVRAPSGHKSTKSLSALPQRQSENAPTSSRTIDTASDAPTTRTRPASLYGNTDSVRSTSTSTPPRGAEGSSPASSPRRAGARVNDLLTRYQQQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGY3</accession>
    <name>A0A2S5BGY3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A/B superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGY3"/>
    <dbReference type="STRING" id="741276.A0A2S5BGY3"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="399" mass="41964" checksum="12F798320DA957E8" modified="2018-07-18" version="1">MTDSGKPSATDDLVLAVFLHGFKGGADTFAAFPTRLQNTLTARGIAFEPVVYPPYDTRGELIVAVDNHVTWLTNLVAERTAKYREAGGKGAVRVILFGHSMGGLVISDTLLKTISTASIPILGLVAYDSPLLGLNPAVFKSTFDKALDYASKGQAALAALGAGYGFFRSATTSSSTDSASSSRNGPPGPASASSGSKSASKSSKSSKEVSVPPPAESASATPGSNWLSLPYLAAAGITGAAAAAFGAAYYNRDTLAQHWTWATSHLSFVGELWKQEELEQRLEMVVAAKEKGIGFHNFYTLIPAKGTVPDRTFLILPHSAALRAHFSPAADTLASDEIHAHMDMFDKSDGMYRLSQETAALVQDWVDKARRGEMGYWKGEPVPGAAATGAGEGGEARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH45</accession>
    <name>A0A2S5BH45_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH45"/>
    <dbReference type="STRING" id="741276.A0A2S5BH45"/>
    <dbReference type="OrthoDB" id="2523676at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="583" mass="62167" checksum="0D40BDB6FF4B3323" modified="2018-07-18" version="1">MPVLHQYDYLFAIGTIFALLDAYNIGANDVANSFATSVASKSLTMKQAALAASIMEFTGAVAVGARTADTIKSGIISSSAFQGNVGVQLLGFVCAIVVSGTWLMICTRLSWPVSTTYSIVSAVAGVGVAIGGTDSVQWGWNGGKGLATIFAGFLIAPAMAGGFAAIVYLLVKYGVLARRNPFPYALASGPLVFFTAAAVMTLAIVYKGAPSLGLKDLGSAGTAAAVVGSAAVVALFSILFWVPFVYCKVARKDYTLRFYHFFLGPLLWWRQPPADAADRAANVVDYRIRADRPDELKPTANAGDVEASQRSSEVDEKIYEDPTPADGLNQRSLLAEEVENQKADPHPIEGAWIEPKNLMIILRYKAVPFIKMIFTHGLTMDIHKEQAGTAGTAEHRRMMAIYERAKQYPNETEACYSFVQVLTACVNSFAHGANDLANAIGPWAVIYHTWSTSTLAGKKTDVPIWMLVAGAATLVLGLVTYGYNIMKVLGNKITLHSPSRGFSMELGSAITVVLASQYGIPVSTTMCITGATVGVALCNGDLRSVNWRAVAWIFAGWVLTVPVVGTISGLVCAMVLNAPHFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHH4</accession>
    <name>A0A2S5BHH4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenosylmethionine--8-amino-7-oxononanoate transaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHH4"/>
    <dbReference type="STRING" id="741276.A0A2S5BHH4"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="89415" checksum="595280555A52A1CC" modified="2018-07-18" version="1">MLSRHLRSHLIVAPSTSVGKSIFSTGLVRASLALGEKVGYLKPVGTGSGDGDDELHLKRFAPGVETACLFHFDEPVSPHLAVERAASEFGSAVTKAPTDTEFAAAVGRHARQYASKVAGQRSSLYIESAGGVHSPTLSGTSQLDAFRPLLPPTILVASAALGGISTTISAYESLLLRGYDVDAVLVFKEDYYENYSYFEKWFQERGIRVGVVEHPPERLPSATEDAKALDAYYGRIADRPLQRVVHQLQQTHLDRMSNLATAPRRTLDQVWWPFVQHGLVQKEEDVMVIDSAYGDHFSTFATSAPSVDGLPRAAASSDSDPVTSGSSATSEAPPSLLTPMFDGSASWWTQCLGHAHPELTLAAAHASGRFGHVMFPSATNLPALTLAEKMLASVGAGWANRVFFSDNGSTGMEVALKMALRAFAERQQLAPERRRKLAVLGLKGSYHGDTIGAMDACEGGVYSERVEWYEGRGFWLQAPEAKIERGKVVVRQDGNEIGSLDTLTDLYDVDRRVESDPLAARYRQDIEAQIAERLACGDQIQFGALILEPVVMGAGGMIFVDPLYQRVLVDTVRSNRELFPAAVDAAREEWQGLPVIFDEVFVGLRRLGRVTAASFLGSATRPDVACYAKILTGGLLPMSLTLASDAVFRSFWSDKKVDALLHGHSYTAHAIGCGVANKTLEILDRMDDRGAFNAPKADWAPASSTLPSSGSAEVVWSKWSAEFVDRVSRHDRVEGVMALGCVIAIHLRAADGSGYQSTASESILRRLRYGEPAGSGGGTSDSSAAVEPFHIHARPLGNVIYFMSSLNSPDETLRAVEETIWAALEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI30</accession>
    <name>A0A2S5BI30_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI30"/>
    <dbReference type="STRING" id="741276.A0A2S5BI30"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="49508" checksum="5645F8E014A74EFA" modified="2018-07-18" version="1">MDPQRAFTKLTKRVPIEKTILSYRLAARELGISVKDAKQILAAYLDSDAAKDRGVTGVYLLSGYLKSDAPSPAAKLNGKHDDAMDLDATATTQSSQNGLDDAQDEPEVVKIKTMLLVQQDELEAKSALFSPAPASHIYALAPARLTSLDLLTASSLSLIRPEVREQKWKAAPESTPAYGGIVHPEGERKVAQGKRKAPPMPPAAAAAPKAGPSGLSSKAKKDDSEDVKPSPAAKAKGKGKEKETASGKGTAKAKKEEPKIRPIGQLGGLFARKFDDSTSKKSKGKKKADSDEDDSDEEEDVKPKKVVPAKRKSTSPAVSRKKPAAAAAAAPPPAKAAPAKKDADIIMDDDDDWDMDEEAFLEVERAAEASAKARADKANASKAAASAASTTTAAKSNESKAERQKRELEAMMKSDDMDVDEDKKPSRAQSLSRTSSSSSTAQSKAANDKKKASAAPAQKSLGSFFKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIE3</accession>
    <name>A0A2S5BIE3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIE3"/>
    <dbReference type="STRING" id="741276.A0A2S5BIE3"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="344"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="803" mass="88278" checksum="F798C500E0978A79" modified="2018-07-18" version="1">MIATNLSGRRSRLFRSAVELVSPICPEGERTSWQVTRMSVRTRPCSSFAASMMGVAAASTLKAEKSSRMGSAPRPNRVPAIPPVPLPRLTRLAGIRRDRLDSSQRRLAMASDRLPAVPILMRHAAELPPSANNDEIEVVAPAYDVTLEALAPEDEKKDANVEADLEAGRRKRSASSVSAVGEWVGLMGGRIRGWTRSAPDSGQSTPTLPKGARLGTVGPWDERFNTMLLRVRAKRPRVGAALVWLRGPSPPWIETELAPLGLPFVGAWLHRTERWCTDKLAPMRKWRTFTTPAFLLVWLLGFIFLVRASFFTTEHFSEGTPNWIGATDSWWYEDTGCGVNATGCTTTPGYTYVFRCPSQALNVELLNPYAIGAESILYDPLVVGGFDSEKTYRGDSWICASAIQHGLFSENRGGCGQLELVGDFTGFVGGEANGVKSQSFDTEFPSAYRFLPPTSQTGCRDMRNDILGYNVAMSVVFSFLIRPGPQAWFWVLVCLGAWHNALASDPVSMPPALATAFERFAPVLFVSYAFWHFAWRWVAPAFEKSGFIIERTVWYLAGFWFGILMNISLNWIPIDRLTPHDISQEPGGLVAVILLVIFLLCVVVNQLRVIRRTGWFFYYLKWYLVGGAVIGVLAALPGLELRLHHWIAAVCLMPGTAFVTRPSAIFQGFLLGMFIDGAMRWGLDSILQTAASLVGDGTIGSARPTFITNSTNFAAYLADGMIAWSPLSDEAVSEGYDSFALLIDDVWRYSGTATNYTLDGLNSTLTHYFRLAYQASGTAGDFTKAATAFMSNATWINPAPGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIG1</accession>
    <name>A0A2S5BIG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIG1"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="90" mass="10139" checksum="2795E5C3EE60F843" modified="2018-07-18" version="1">MTTLEATDSPRRARLTFDTLAFDVKLLIIAALEELEWSLYNTAISRGSNIGRLHRTTRSWRAATRERVWKAVAMEHLAGLDYGALHGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIR4</accession>
    <name>A0A2S5BIR4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIR4"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="388" mass="40962" checksum="55A4AAB4DD52B2DF" modified="2018-07-18" version="1">MAKSSTSKGKRVARAPEPISRPADSSSSSSASPSPSPEPEHSSASSDSGRDSSASPEPQVAPARHEHRALDPEALKYAPPEGYKPIKPTAGASGIDWDELKEDGDLELWTIRVPAGVKTKHLEGLTLTLPEGNLADPVQPVGHFAVKKAEYDVYLASVAASEGTGSKTNNGKRRRDAGAEADEEGEGQAAAGELQTLVPLLPRKSQGNKLFQAPRPVSRTLTITRSLPASVIASTSALATHNDGHSTLIQSQPSPVPGAILTADELLDADLAAKRKRQVRGDAQRDQPSDLLKFRMGAVAGLGAQGGQGRYHNPMEAIVPSERDLHLFDLAAPAPDGADGDVEMADNAAAALEDVEPTPKKEKKPKKEKRAKKEDGESPRKKKVKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIZ8</accession>
    <name>A0A2S5BIZ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIZ8"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015391906" description="GDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="47961" checksum="CD7B99A7B8CE98F9" modified="2018-07-18" version="1">MLPASPYVRYGVSAVMALVFLHVVGQLASPAYSHHTSLDQAKVRLGLKKSPASETWVDGRRVQPWESAPVRTPEDPDALAKAASRIPHGRESATFVMLARNSDVWGALDSIRQVEDRFNYAYHYDWLFLNEEPFNDEFKSHVSALCSGKVQFGLVPDEQWGKDMPSWIDRDKAINAINAMGQKPIPYGGSLPYRKMCRYQSGFFFEHPLLDSYEYYWRVEPNVKFLCDIPYDPFKVMKQHNRTYGFVVTLYEYQETIPTLWQTTKDFIDKNPQYLAEPNMMEWISPNKGDSYNGCHYWSNFEIAKVGFWRSEAYRAYFKHLDQAGGFFYERWGDAPVHSLAVSLFLRPDEIHFFNSIGYRHEPFQMCPIPAVGTKCTCSTSPDDPHNNFEFHGYSCTPAWKKITHYKSGTAFSADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ03</accession>
    <name>A0A2S5BJ03_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BMF94_0334</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 16"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BJ03"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="1724"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="POY76742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1774" mass="191282" checksum="C22123BC8745D34C" modified="2018-07-18" version="1">MPPKGKSSASSATRKKQAAKAAKKAARDAGDDDEIDVDQVASQAAAAVNGSAQPKQRGQKKVKKDRFAPKVKKYVPPPPPPKGQPDPVDVFLVGRGKQPDPQLVVILRRFVKKDEATLLKGCEGLEDWVKETLRQEEQQEGEDWEREMRQEGVVDCMDVWASHFPRLALHPSRRLRLQVHALHSLLVGAASSRTRTQAPLIASTRSALLAPMWIEKSEFIGAWCTAAHDSDRSVRRDARASWDAVVTAVDAGENVEGIRLSEHADSIASFAFSVVLGGGGAGYSAAGGADTPSSEAGSTSFNTSTLGEDPAFLRSSAISALAYLVQTLPTPLPLSSETVETLLGEELWDLLTRSTAPGARDQPPMVRKALYDLLGAIVGRKDEELLLSVTPASNDDEADQSADEAENDARLRTIAGKVLGNCWEDEEGWPSIILFLRRYPQAWSLADGVLGEAGDDDEDDAPESANGADETFKPSPTVSLFLQHLTLGCSSHPTTLYPTVLLILATIPIALLPPTESALSLLFESFWAAYSSRAIAMGGARAVQAWAEALLEAILFETCRIEDPALSAAIARHWIGERLFALTVGRSEEAKVPNGARTVATSFEQPLGRLAAREDQSAFEAAWDAIAQEVGAVSSEAASSVATDRLAPLASALTAFVGSQNETVTTRGQALALQSLRSSADGIQLASSRPSEEVLDLIRTVGSLLDTDDSRQILDDMARSHLPGLLAESPAALSLFVSRLAVPTTQRDTLWRSLFSPPPAPAVLLRLVDAVSESGLAGELPSADLDSHVREMATRVLTDAHEQADELDLLRRIVVQPLPLVNPSLPSELISRAGRAMSDLVRPVLRIDESSQAQGQTLDGLVAPSALVAHYTQLRDNAWSAFEVPDLAVTVFDVGHALPVIALAGGTPGEAIAAAQQAFSSIVGARGDEAVKAVMAELRVRLADSSSAISTVALVSMTAELLESYPATVHSLGELLPSKPDLEAAFGSVSLAPPAPSLCILDPLVPLAETTSPATFASTFDRSFLSAYGRVLVAVLEVSARDHAGLRRQASWLLPHLLVLSDVARDGLAKPPSAAYASGVFAPDVPDDILARVAAAADGASSYLLSTLANALTDDWHGKAVAHLRVKELATLSDDSDPLLSVLDSLWRTARSGDPKAIYAQRAVRTVLGAVLRYSEDGGAADAERWLALASSSATSAPGLSCAVLYAAKSLLLETPKYERYQNELAADLAGVRPAQLDVKGVSALRLLLAAAPPVDAPVIFLPQQRTMFLIQAITRWIASDEPIPDEMNAGLVELFCHLAPIVQDLSGGHWDLMFDLIESNLESADWEEPATLPAVHHSCLLLAQIRELSTANAQLRDLAKARIDTSLEAVLRLFVSRPVTRTRDQPRIVVVETMAKLVKTLPPKLLSMESSFDQLLRLLQDPALTVQLSSYHLLQRVVEKHVADLVVEAELDAEDKLDIRLPTALVSALGDKPTEDEPAEATAYLLSWLLTFGFFESASPRLRAAFLEQLRDTGLVVDSFLPTVFSLVRLSDRTRPIDLAPWTVDEFHLDLLDNRDRTSMSVLAAHAYYRALKTVPSVIRAYATSLQNLQLSRTLQTFTTRHFSPLLVSDELAVLRDTTSPIGQQLRDNDDFTVKVASNGSEVKVVFIVDEEAMELGIRVPNEFPLAGVEVRDVRKVGVTDKQWRAWLLAMQQVITSQSAAIADAILLFKRNVTLHFEGVESCAICYSTVSTVDRSLPTKTCKTCNNKFHAGCLYKWFTTSHGSTCPLCRQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJD3</accession>
    <name>A0A2S5BJD3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJD3"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="176" mass="19673" checksum="C31B695CE903B4CE" modified="2018-07-18" version="1">MADLTSDRVCVVCVRPATLRCSGCAQPSYCGRACQKCVWPAHKWFCKQDEVGRRRFSFPPLMADEAKHFKPRGNGATPATRSIVEETGVEDWHLAIYRAGWTKPPVLNESARNTLLAALQRPKEDCPVAEPERSYILAQLNQLLLMHDEQTNVDFDLEALEDPGAAAFQMCGLRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZ53</accession>
    <name>A0A2S5AZ53_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_7108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000177">
        <property type="protein sequence ID" value="POY69889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZ53"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015403758" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY69889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="142" mass="15489" checksum="691F8630D97E0998" modified="2018-07-18" version="1">MKISLALFAAAAFACVAQAAPVEADTQDTAVIEARDRDDYRPGWRCYRYGRRRRCYRCPYGRCGGGGYGGGGGYGGGGYPELIKRDEVTTEAAQVDSDKVDTDVAEPVEMYEEPVEGWGYGPGWGYGHRHGWRGGWGYGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZM7</accession>
    <name>A0A2S5AZM7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_7031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZM7"/>
    <dbReference type="STRING" id="741276.A0A2S5AZM7"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY69987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25331" checksum="85EF9FE9DC0101A2" modified="2018-07-18" version="1">MAPTKSNKKGKGRATNELDANGRPPKIKRVKEVVFDADARKEYLTGFSKRKKAKQTIRRNKAIEREKTALNQMRKQIRDERKERAAQNVKMAKEMYGDAGSGDEDDDDEDMSGGGSDSDDSDAEHCSEIAYETQDALTTVTVEPLSLSRSPTPEPLPALDESDRPIRSSAAAQQQQQGSVHKKRVKNAPQARPKLTRKEKKDRATGPKKVKKKLDNKMKGTKGRANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZT8</accession>
    <name>A0A2S5AZT8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000151">
        <property type="protein sequence ID" value="POY70050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZT8"/>
    <dbReference type="STRING" id="741276.A0A2S5AZT8"/>
    <dbReference type="OrthoDB" id="2537877at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1070" mass="113335" checksum="9FE518E4399EFD86" modified="2018-07-18" version="1">MPARRQSVDTGTADQRSQPPRSFSGSQSASGDGDKGAPDSSARTSRAPPSAASRGSGRGRAKIRGKGRVATSSARRTSAAGSETPRENGAGSDMSSEGSDDVELGGVDPARGAARPPRPISPELGLPALLAAASEERPRSSSLSAISSRASSPDDAPAHLLIPMLPFFSRVENDSLSPLSDDTARGTSRRAEAEPAVEPEQSPSTPVQNNLPELNMHDSLSELESSDDDAPLAVRARQGGSASGSRSLSTNSTPAPPGTENSGSLSPAPKRRGRPPGSKSRQARQSAPARTQRGGHTSRPDSLAEQPQETATSELVQEEAPLPEPEDAVLEPAPKEEERDETPAGESAETQAAVILQALEVEMPQSEVMSREPSHEGSVDSSAIATTPKGKGKGKGKRGKKALPEPVERAKRRKLDGLDKETLEKLAARETARMKFLGELEAELLQVEQHSHPLLDFTYARLQAEKEKKLAQLRKYQEQREQELARSLEAARRASWRQWSDGKDRMRMALYLDNHRSLKSLLDEEKVFPFFRDHPLFVNNHDLPPTGYYRGPQRDPTFTPRALVHAGHYVEPPPVNTALVHNVWSLGADEIEADLALFYDIEDVAPPVPTAPPPPANNSHAYQRPYPPHHLEQPPNGATFSPSGPAPHPAFPRPAFQPYTTNIPPPLLATAAPYAMPASEVQPFAPHLQMQTRPPPAATQFIPAPHSAPSRPPPSFSQAAQGPASSVPGPQQRARPASPPRAVKLDSKQSATPSSAVASGPARSQFAPGINAIPKARTPRSPPRTQQPKPSLPSMSPRQHQPAGHPVGADAPVVGQYRVGAQTSNFAPSVSNRSGAPQPASTTVLSTQASRSLPSLAAPVWPAYNTEPSPFRPSVQAPPPPQQSFKPATAAPATNPPKSGVWAPAPPVMPAPPQNNGVLKSWLPPARPPSHSSAPLPPIRQTLFPTSFPTGGLPPVAKHLSPPPPPTPMSLVGTADRIAAPARSPQQARPAFPSMQKHDPLPLPSWLRPNGTQDARSAAIAPGSLPGPRLPHELRMAAEAIPTLKDGPRFPTGGAGFTGGAGAGAGVRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B030</accession>
    <name>A0A2S5B030_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000141">
        <property type="protein sequence ID" value="POY70140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B030"/>
    <dbReference type="STRING" id="741276.A0A2S5B030"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="235"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="411"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="58832" checksum="FF280D7E88E19BCD" modified="2018-07-18" version="1">MRVSFDPEATKRWLIQALDPISDAEPALLADFILALLANDVADINELRKNCVDQLVDFLEDNTAPFVDALLHYLDSPRDAGAPLPYGNGRADAAGPHGGDDAAMRDRKRPRSPQPPSMMPHQQGQPFKQPRITPNPFLFPPPMGMAYPGAPPFPGGPGGPMQGAPLQPCRDYHFRGYCPRGATCPYQHDAAPANGLPPAAPMAAAIGVPGRPAPRRMPPPRQGHAINRPPRGATRSIRVEHIPPACANEAALRQFFNPFGKIAAVNVDLNTCTALVAFSEPSEAERALASPQPIFGNRFVRTYRTQEEPQMPPAPAPAEDAQMSESAPTGGEAPSPAPISDAAAEAASRRAASAAEAKAKASERAEQLEANSARQKEVLSQLDGADKEQKRALLREMRILTAEAEKLLREAKEAAAAPSGPEDARARLERLRKEASALGLPSAGGSPYRTSRPYARPERDPKRFRLDLRSKRVVAEPVTDASLGELQTHFETYGTVRSLGAKDGSSAYAFEFDSREAAEQALAAGAPTVGGEPVQLRWDNEPASNGSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B075</accession>
    <name>A0A2S5B075_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B075"/>
    <dbReference type="STRING" id="741276.A0A2S5B075"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="49596" checksum="37AF12F1055BB832" modified="2018-07-18" version="1">MTPPPPAAQGPSRRLLALLVTGMLVSGCSNSLWSKWQDMQCVGNCDAHNPAKRRLFEQPVYQTITMFAGETLCLIAFTILNSRFSPAARRRHRREAAYEPLQNVSSDPTTGRDASSLKAKEMSRKDAIMFWLPAMCDNCATTCMNVGLFFVPVSVYQMLRGALVLWVGIFSVLFLHRRLTRAQWTALVVCVIGVAVVGSSSLISHKRSEPETQAEDGTVSPLVGIALILVAQLFTASQFVIEERIMEHHSVEPLLAAGYEGICGFITTVVILLIAYWLYGSTPAGRGGYFDALQGFHEIIDNRTVWTSSLVIACSIALFNFCGLAVTRSVSATARSTIDSCRTLLIWAVSLLLGWETFNPLQIIGFALLVYGTMIYNGVTSFPHWTGLHRDELPGVPHLSAPSIDLPDEDDEVALANPVEVVVARAKDGASRSRSGARTSVEGERAPLLPHEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0C9</accession>
    <name>A0A2S5B0C9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0C9"/>
    <dbReference type="STRING" id="741276.A0A2S5B0C9"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="322"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="584" mass="65556" checksum="A7064D6D28690CB5" modified="2018-07-18" version="1">MQPYDLVDEGDFEGADLAIPAVAYDDAGNEQIAQQQRIAEAAASQAHALEQLASVPEPVKRYLISLWSLLNQPNPNLAEIHSAYEQGWNRLSDKFFPKQEWPDAEVIAPLVNHDEVFLTLYRELYYRHIIARLQPDLRDRIASYEAYCNLFNLILNSSGPVPLTLPIDWIYNIIDEFVYQYTSFALWRNKTQGKSDDEKAILAESGQVWSCYSVLNVLYSLIQKSKILDQLAAAQKGEDVEAAAGEYGSIPLYHHLGYFSVLALVRVHVLLGDYTLALSMLDHIELDKKALFTRVTAAHVATYYYVGFAYLMLGRYPDAIRSFSHILFFVLRLKHFQRGSQFDQINKTADRMYALLAICQALCPTKVDEGIATAMKDKFGEPYGKMVRGGPDAVASFQELFIHGAPRFISPNPPPYETESDEILSAFAQQPDPSQHQLSIFLAAVEPQLSTSTLRSFLRLYTTLGTDKLAKFLDLEDEETVLEMLMTAKSAARRVTWTSGGLLEGEETGVSDINFGISEGHLSVAQSTTSRRYGDFFSRHSLKFADVYDQLRNKPLPVPKPRDRKVVPAVATNGGDAGRREVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0N4</accession>
    <name>A0A2S5B0N4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_6624</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0N4"/>
    <dbReference type="STRING" id="741276.A0A2S5B0N4"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="41"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY70344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="271" mass="31118" checksum="A4827BAC0FBC1930" modified="2018-07-18" version="1">MGSVPFAVGAFSKLFLRYGCRDVRVEGLPTFLQALQSDRGVLTLANHVSVVDEPFMWGSIPLRNFLNSRQLRWTLGASDMMFNGKVDSWFFTKGQVIETFRGKGIYQKALDVATKKLDEGNWVHIFPEGRIKQEDLHNLRRFKWGISRILMECERLPLIIPVWIKGFEQVMDEPRVSPNFAPRLGKDVTIMFGESINSAIEPHLATYHELFPQGWRPATYDRPVGADLEAEPKELALMRSEMAEALRRELMRLGDRVEEVERQPPSKLVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0Q0</accession>
    <name>A0A2S5B0Q0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0Q0"/>
    <dbReference type="STRING" id="741276.A0A2S5B0Q0"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="185"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="459" mass="46582" checksum="1F4445678957B11F" modified="2018-07-18" version="1">MQTGLERNGGGGGGARRGGARPSRGGGALRNSTGHAATRATPYERPAATASTADKWSHDLFAPSSNLYTPAVNFSSSARHVPAWGQPSASLRPFGQATPAAQPLIVTATGAVTTLATPSSNGAAVPTGPAMGVKGANAAATAKRQADLLRKQQQRERAEEVKRRKELEAERQKQVKIAKEEDLGFVVEVAGLVNGTSAEDVQTAFGAYGEIRFCFILDPNAADLIARMTFTRHDDAAAACAKLDGAIADGRPLRVKLTTRTPMPAPLPPLPKAAAASASSTPTLDLTGAAEPPQRSAPPPSKMYADQIEAAQAQVLVAAPARASTAAMDVDMASVPVGPAAQRGRGAPVAYLPGAPPVNPLAKRLGPSLVKESVQGGAARSQQQAVPPRQPSAMRTNGRAAADGGFGNGVAGSLMARLGVAGAPAKGQNAGGAGRQPAGQQQQRRSGGGGGASLLARLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0T7</accession>
    <name>A0A2S5B0T7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0T7"/>
    <dbReference type="STRING" id="741276.A0A2S5B0T7"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="372" mass="40162" checksum="979CA4E53DFB4B2D" modified="2018-07-18" version="1">MPSDRYYGFQDLALLCEHVIASLFSVAPQATAPVDAAGVAAKPDAGSAAIPNLGEFIAYALYRTRLPVSITHQALLLLTRLKQRYPSARGTSTSPHRLFLSSLMLSSKISMDDTYSNKSWQIVGQGLFELREVNQMERELFAFLGWNVVVRDEELELWVQEVVGPYEAERELARSLALAAQEQQRRSMEDRKRRRDVQLPTPSPSTSRSPSPSTLRHRNASDAAIALLRGHPSHSSIASSSSSSAYDSSASPSGSSTRSRRRSRTEYRTSSPYSRSSSRAPSTVCSSYATSPVSGHGHGIHTPMSPCTPAGPLTPEAANDKAWPTAQDGCTDVGAEAAAKLAAYATLHRPHLGVEPVIAGVDDVDGYSAAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0Z2</accession>
    <name>A0A2S5B0Z2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0Z2"/>
    <dbReference type="STRING" id="741276.A0A2S5B0Z2"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="217"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="424" mass="47259" checksum="2AE46C7AEABB0F24" modified="2018-07-18" version="1">MDRWLAQVKTRYQAGDGPQFAALVDPDPTSTAFTSVRQLVATAPDLRATTYTSLTRSAFSDNRPLADFVAVFLLYVRDANLPTQDAAALAKAYPLLEDCFKAADRCFATSEGGWFVPTLRKMSRALVTLALAIGRAQRDPRLVKAGEAARMLARPIAIAANDRTSDSPCKRDALFFLANSTFRVYFALSNLRLCDTVLNNVQNANAPMQEFPLADRCTFLYYRGRIALYQRRLPQARNDLRRAFSLCRADSWRNGRLILTYLTVASLPLGYFPSADLLQPFNLSEAYTTLIPALKVGDFRTVLSELDRCQTWHLKCGNYLLLREKLETVCWRNLARRTLFVLTNGSPLPPTGPPTLSLQMLLVAARISFQDPTLDIDDVESMCVSLMEQGYIKAYILHSKRILVLQKGPRAGFPPIATVNAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1K2</accession>
    <name>A0A2S5B1K2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1K2"/>
    <dbReference type="STRING" id="741276.A0A2S5B1K2"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF14">
        <property type="entry name" value="AQUAPORIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="37991" checksum="789C1A5A01143B48" modified="2018-07-18" version="1">MQAQREHLNRDQGDVEVGAANLLQNLGGEAKHAAHLPEPPRWLVNWERRRPTLLIECIAEAVGVFFYVYAGLGASASFFVSSAEKVAGFGSLLTIGLCYAFGISFAIIVAAPVSGGHLSPSFTLAFTVFKGFPIRKVPYYILSQLIGGFLAALCVYGVYKQQLVAITAAMRESPTTAAAIFSPSGPAGIFALFPGPTQGAGYLFLNEFIANIFLSILVFSVLDACNFFVALPSAPFVIGLGYFVIINGYALNSVSLNAARDVPGRMVCAAFFGKECYSGYKAYTAIAALTTFPASLIGAGFHTLFMSDSAKMIVNHPPSMADQISVLNESRGFPAMNRAITRETVYHDNGLGSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1V2</accession>
    <name>A0A2S5B1V2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1V2"/>
    <dbReference type="STRING" id="741276.A0A2S5B1V2"/>
    <dbReference type="OrthoDB" id="2530339at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015511472" description="CFEM domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="8">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="354" mass="32543" checksum="A71BEE3FFF58F67D" modified="2018-07-18" version="1">MLPPLVLALFAATLPLSAAQVFLPSSAPQCARNCFQIKVVQAPYLAPNVNPSNLAGLCATPSWFEAYANCMRDNCPNVNDVTTGLTIGEQVCAQALLSVGSTFTNPGSASASGSGAGGAAGATTTSNAASSSSASSAVAGGVAGGISSATSAVSSASSVLSSASASAASAMSSATSAASSGVSGAVGGLSSGASSVSSALSSGASSGSSALSSGASGVSSAASSGSSVNAASLSSVGSSVASELLSSGASSTMSEGAASTGSAMSSGQNSQSSNGMSNGGQTTTSMDAAASSAYAASLSSVASRNVASVLSASSAGPLASGGASSGAAHLGAPIGAIALTTLGGLFIAILAVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B265</accession>
    <name>A0A2S5B265_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B265"/>
    <dbReference type="STRING" id="741276.A0A2S5B265"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="11">
        <location>
            <begin position="142"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="10">
        <location>
            <begin position="353"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="630" mass="70017" checksum="04ED671CF0F96D81" modified="2018-07-18" version="1">MHRSLASGTLRATRPRARQPAALQAAFQSDAKQRNKLKFDSSEAVDENGVPLANTLHENQEFLAHKKNERPIWTALRGKALLNEPSLNKGAGFTMEERETFGLTGLLPHEVHSLDQQCKRAYSQMQERPSPLAKYTFLSSLRDQNIVLFYSLCLRYLDSVLSIIYTPTERTLRVMYRFPARPDLPDVQVGEAIQKYSTIWRRPDGLFLSIAHQNKLREMMMQAKRPKDIDLIVVTDSEGILGIGDQGVGGQLIAQGKANLYTLGGGIDPSRILSVVLDVGTDNPALLNDPLYLGLRRKRVRGKQYDEFVEKFCDIVREDYPQAMLHFEDFGVSNAARLLAKYRPIQSCFNDDMQGTAAVVLAALVSAVKVTKSDLKDQRIVVFGFGTAGYGIADGIRTALMLEAGLTSEEARKVFWCIDRPGLLTSSHTDSLRPGQENFIRDASEVETWERDEEGRIGLLEVVKQAKPTILIGCSTMSGAFNEEVCREMAKHVERPIIFPLSNPTKLAEADPADVNEWTNGMALMATGSPFPPVRNPNGKLHKVAELSDRMITAGVAALARLAPCLQDPDESLLPAMGDVRHISVKVAVAVANAALDEGLSRLGRTDRFTEEEIRSFQWDPVYRPLELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2E6</accession>
    <name>A0A2S5B2E6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2E6"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="483" mass="53025" checksum="82E61D5FC734213C" modified="2018-07-18" version="1">MQDKLNAINDPLDLLPGSALGPFRLCSLLFNVLNHVREYSDNYPQVQLAWDEKNPLTGPVHLTLTTPPLHLTFVGPSQRLARIQVTGSRPGSHVAYRSQRVQEPGRGTTREEEEEVEEEDEDEGIVKRIRRILGPTYGSSKAPVAPGTIRADPEEILSYPGVAFGISTRSSGAQQLQRIVVTPLPAPESQPIDQAWLHPKLDESRIAVAHGDLARATIEVRPPLKRISSALLNDEQYCDQLPRGGESSRPKVTLAFHSLSDPPPSRTNRRGDGFRPVEPVVLEIGETTSEDVLCDLGSAIRTFWKEDDRLSIHTAAVGASRESALEPNPYFLSYPHLGLTLMMSVPNSSLLPHLVEKVILHSNVPGQVQFGRTTRALWSLRCDNISATEQVKQGEEVQEVKVEDGWTKVREALRRSGAREDDKPMILDRTAYSSETGPTPGASGGSLSQDAAIKGQTTEIYGFSSGVACEVTQSGDIETLWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2F5</accession>
    <name>A0A2S5B2F5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_6123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B2F5"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="230"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="482"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY70945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="555" mass="61831" checksum="97A4A53E228E1637" modified="2018-07-18" version="1">MSSWKFGKKLKEVASGRSASANPNPATDSPSAPSTPNPNSSGQATPTAGSHEEGTNGGAAPVARSGVLTIRVVEARNLHPPAGAQLPPGIRDAVEQAQAGMARGARESLQRKQMWWLPYVVLEFEKNEILIDALGGELDSPTWMFRAHFDVSRISDVTISAYLRTSPIVPGQNRNDMGNDLFLGGLQFLPSFDTNKPLDQWFRSTSGSGEFHVQVSYKPATTQHLTINDFDLLKVIGKGSFGKVMQVRKKDTGRIYALKTIRKAHIVSRSEVTHTLAERTVLAQVNNPFIVPLKFSFQNAEKLYLVLAFVNGGELFYHLQREGRFNEHRSRFYAAELLXXQFNVIYRDLKPENILIDYVGHIALCDFGLCKLNMAEGETTNTFCGTPEYLAPELLLGHGYQKTVDWWTLGVLLYEMLSGLPPFYSENTNEMYQKILSDPLRFGDEISPDARSLLTGLLTRDPQQRLGVNGAETIKSHPFFAKHIDFKKLMQKKIQPPFKPNVESAADTSNFDPDFLREQPMDSVVEDSHLSQTVQAQFANFSYYQPAGAFGESVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2H7</accession>
    <name>A0A2S5B2H7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000091">
        <property type="protein sequence ID" value="POY70988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2H7"/>
    <dbReference type="STRING" id="741276.A0A2S5B2H7"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="426" mass="45087" checksum="D2843CDD397E9CB2" modified="2018-07-18" version="1">MDSADAALVRRLSHIQHVLLVLSGKGGVGKSSISVQLALALLAHDPTLRVGLLDVDLTGPSLPRMLGMEGRDVLASDDGWVPVYLDASKAVQAARDNGIVVQAEDGDHEMQEAGDGQLSKEPTSTDSDPAASGKTSRSGGVLACMSIGFLLSSSRESVVWRGPKKNAMVKQFLAEVRWGELDWLIVDTPPGTSDEHISLLESLRPLLLPNPSPLAPPLPTLSSLLVSTPQAVALLDVSKELSFIRRTRLPLLGLIENMSGYVCPHCRDVVGVFGKGGGEDFCNKDCDKRAGGKVPEGEEEGVGCRFLGRVPIDPELVRLLDAVAAEGGANALEVDTEMMGTTATTSTPAPSDESRTSGGLPTESGAPAARPRSLVERYEAIASFPVVAEIADRVRGLVAEQVEREANEGGRRLVAVERRGGVEPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2N7</accession>
    <name>A0A2S5B2N7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2N7"/>
    <dbReference type="STRING" id="741276.A0A2S5B2N7"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="251"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="470"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="733" mass="82275" checksum="7180E24298348C31" modified="2018-07-18" version="1">MPHDGVQTEQTLKLPMHDLIERAPTPHSVTNRRLDITKKKHRKPSATLSIVFVGVAVRERPDLDDKGAEYAIAVSDGCGIVQSEHGFRPKGENSANALDHILELARKYTSQRGHKIQIVALARTCDGLHPNLTFDADKECEGTNLDYLTRVWLELDAIPFLSSREATEGKFSLDGQATAAIDEALTTLVPMSSSTIRVCMSPLRRVLVDADFRVRLYSLTELKNVTSPALWSAFTNLGEALAAQKTSIRFFSATPRGGGVALMRHSLMRIWHMTGLDVQWMVPDGDPATFNITKRKFHNVLQGVAEPDVMLCDQDKELFEAWTIHNYKRYWQGEDSPFRRLDIAVIDDPQLTALIPIIRRESPRTKIVYRSHIQIRADLIDKGEKQQCATWDYLWSFIKLADVFVAHPVEEFVPQVVKDSMPVVYMPPSTDPLDGLNKPIQREHLNMYRHTFDAAVQSSDGRHVDWSRGYIIQVARFDPSKGIPDLTEGYRLFREQLERSGVEGNVPQLIMTGHSSVDDPDGTLVLHQLQEQVSDRKFEHIRDDIFAIRAPPSDRLLNAMLRGADVVCQVSTREGYEIKVTEAIHKGKWVIASNAGGIPLQVRGGTDGDIVEPSDSQGIADALLKFYSSESLQASRSEMIANDIHRLRGGRHGAHGSGPSERDLSIGNATMWHVNFAKLIGISGHVELRDEQKGLLDRLEVPRHGRRACDLASIKDRKVWDVLVEAFEQTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Z7</accession>
    <name>A0A2S5B2Z7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Z7"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Z7"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="502" mass="55719" checksum="CAFE39C0261FB681" modified="2018-07-18" version="1">MEKPLSTPEMEKGSLDLVENSTEPVVIAGRTLRTLADIDPDAEKRLRRKLDRRILPIIILIYLLTFVDRANIGNARIAGLERDLHLKGLDYNILLTSFYVAYVVAELPCQMLTKWIGPGKTLPIFSFMFALFTLVMAFVHTKGAAIAVRFMLGVAEGAVFPGIAFYLSRFYRKDELGFRLACYIVCAPGAGAVGGLLASGILKIDHIGWLRSWRLIFLIEGIISMVVAIVSWFLISDRPSVCKWLTPEERELAEFRLVAENVGQHEAVDRMHSKAVWSGIFNVNTMVVSLIFLFDNCVVQGVGFFLPTIIKSIYPGETVIQQQLRTVPTYVVGCASTLASGYFAWKTKRRGLYMLLSAPFMIIGFVLYIISLRPQIRYAAAFMVAIGAFNFGALATAWSAANVSSDTARSSAIGTTVFFGNCGGLISTWTTLPKDAPRYLPGNTFNLIASCLMFILAGGLIVWQKRENKAKAAGRDDHYLEGRTEAEIADLEQKHPLFRYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3E4</accession>
    <name>A0A2S5B3E4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B3E4"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1386"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1560"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1679"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2546"/>
            <end position="2581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2557"/>
            <end position="2581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2581" mass="277712" checksum="73FA2F9F7606A8E7" modified="2018-07-18" version="1">MAEQKGGGDWDAVVQSARTTLAGTRPGPRKEVLEQLRLQATKPSLEASQVQDIVRLLLPTVSKYQDAASRQAVVGVVAVLVARDYAATAQRGDNDAASSSAAAQQANGKPASNLTQGLIKWLEGETAKVEKSGATSTRLALLGWAATIYGAVPADSPLDEAPWLSLVTSMSTLLNAILDDSNGAKETLKKSALVVTRRAVRTRHEAIPRLVRSLTAAKAEPTFRHAALVGVAIDVALRLRDPKGRHDVGKTYVSELTDVVRGFYLAAVVPNKTVPPQHVLAAFTDFLNATVTPESATSTYLPAFEKALNRFAEPALVILEAFIASVPSIAQSDATLRQRIAAAVLASAKSTSAPARVGAVRVYSTLYSAGPEEELLPIAEQVYTPIRQGKTNSADHRTALFTILAAFPASAKLSPEIASSVLGALGKETTEHTVAAMSRALSIHLPFALAANASVPAPQSAALVKMMADTKPPLRRLAQVTVGNVFWTLRQLDADATEAEKAFATALWPGFEASLKTVTTSMLNSPSGPLEGYVAVAVLKSRANKWQVKKIDDAVAANPTMQTLGQTGAKPNFFLYDKVWRKATTAEDGIWLVHALEAYFAAEEETIAKDETIRAGFAAALVQLVTEGATHDVRTQVANFVQAANVHSPKLLHLALRDGMRAWLVQQEKAKATAKPVAVSEDALAPVDFAPRLRQLLYALASFDHALEADVREDLLVALAVISHHPRLATSEGSLWVELLMKAKLAPDAMIKQHLGKLIDLVLEDAAFVPSSKAFSDAAFATATTMALVLPEQAIPAVFAQFEDDLEPAHLDFIGATEFGVWGTPEGQAFVDVLADAKKKSATPVGKANSKEHQIALWEAELRESLARKKPVATQLSKQDRQAIDKQLAVEAEIRSQVATALGRLRRGFRLALCLVDSHAELVREYLASMIEKTLAVIKLQPVTLVAEEAFTTYKALANICSERLGVFRVALGVAVLRSVEAQVVPENFRAEPLPDLVSRVLFQLRYLAEQQPFDAGTFAYAAPLTSKILRTGGVGVDKSQAEAALEQLVLALDVVGFHVRQCGDTAYPRATLIGDLFAALLGYPSLSRPAATALADLGNAIADNASEDEIAAVLDGSLAEEAFVRLAALQALQPLDLTELEFPTSLWILCHDVDARNRELALTIWQENGLSVPDSFLTHLVPVLSHASNAVREAAAAAIADGIVLHPDHVADALVQIIAEYEDKAKELVPEYDRFGMLIEESLSREDPWKARKALATALRLMAASFSAAEVKTFFDMLIDGKALGDRSQAVRSELLEAAQVAIDLHGKANLQDLIATFEEYLARPRSGDEVEDLVVESLVILFGRLARHLDPSDPRVKTVIGRLVEALKTPSEVVQAAVCDCLPPLIKVTSDDTPDLVDQLLNDLFNAPKYAERRGAAYGLAGVVCGRGLSAIQEFGLMGRLQDNAEDKKAVQARQGAVFGYEVLATVLGRLFEPYISDIIPTLLACFGDTSIDVREATQDASKAIMSRLSGHAVKTILPTLLEGLDDKQWRTKKGAIELMGAMAFLAPRQLSASLPTILPRLTEVITDTHKQVREAANSSLKRFGEVVTNPEIKEMTPVLLDALIDPARKTPGALDALLTTTFAHFIDASSLALLIPILDRGLRERSADVKRKSAAIVGNMATLTEPRDLIPYLVQLVPLLRDVLVDPVPEARSTAAKSLGGLVERLGENNFPDLLDQLMSVLKSPAAQVDQQGAAQGIAEILAGLGIDRLEDLLPVILQNTSSPRVFVREGHISLLVFLPVTFGDRFSPYLGKIIQPVLSGLADDSDFVREASMRAGRMIVANHSTKAIDLLLPELELGLFDEAWRIRQSSVQLVGDLLFRISGISGKIGEVDEDAAEDDNDEAMPGMEAAKKALIEGLGKERRDRVLAAIYIVRQDAVGAVRQAAIGVWKALVSNTPRTVREILPTLMSIVVRILASPAIEQRETAARCLADTCRRLGEAVLGEVIGILQKAMSSEDRRQREGVCLALTELMANSSKSSLEAHEDVVIAAVRSALVDADAAVRSAAAQAFDVAQQVIGTRSIDETIPTLLDALHKPGPTADAALEALREVMQVRSDKIFPVLVPRLIAKPISAFNARALAALVRVAGSALGRRLTHIVDALQSALESEQDEETKEALDGALTAVLVSVEDHESGLGSLQMHMLGLIKHENPKKRVTGCELFARFCQSTEADFSDYVVDFIRQLVSLFDDRTPEVVGAAWSALDALVKTISKEQMEPLVVPLRRTIEGVGVPGHPVDGFSRPNGLKPILPILLQGLLAGTAEQREQAAYGLGDLVERTSPEAFKAYCIQTVGPLIRVIGDRFPPPVKSAILSTLTTLLTRVPQFVKPFFPQLQRTFVKSLVEPASISVRKRAVDALGALMQHQPRVDPLVTELVNLTASEEGEVRDSVVNGLAATITAGGKNMTENAMSSAVDIISEAFAESPKDSYAQAVARLTAAVAQHAPDTLDFLIESFILATSTDLPPTPLSALALREMIDSAPAVLYEMNKDATVDRVLKMASGAATGGTANPAIARPARDAKDLMKERDPWRDDDEVLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3G7</accession>
    <name>A0A2S5B3G7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3G7"/>
    <dbReference type="STRING" id="741276.A0A2S5B3G7"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25049" checksum="E0C5F35AFD5C545D" modified="2018-07-18" version="1">MSQPSSQRAPGYLWVYTEPGQTATVQEFHDWYDNEHVPLRMQHIPEFETGARYQASDDQKPGWSAAYDIRSVALFSDPKYTRLRANRSKREGDLVARLETLDRRTCEKLGETSAPPKADQAPEFVLTLGTDDKPDASELDSFKDVKGWRRSHYHHVYDALLTGHGREPETNVAPKYAVIHEFDDESYVDSAAYKEATAGKKEVRRWKLYKATPNTAPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3I5</accession>
    <name>A0A2S5B3I5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_5628</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B3I5"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000580">
        <property type="entry name" value="AGC protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="1564"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="2051"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="2411"/>
            <end position="2527"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="2721"/>
            <end position="2836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="65"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="648"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="700"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="874"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="945"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1218"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1496"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1804"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1953"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2212"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2258"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2288"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2425"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2550"/>
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            <begin position="14"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="68"/>
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    </feature>
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            <begin position="95"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="131"/>
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        <location>
            <begin position="169"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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            <begin position="236"/>
            <end position="248"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="293"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="373"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="397"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="11">
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            <begin position="446"/>
            <end position="455"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="515"/>
            <end position="535"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="549"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="728"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="774"/>
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        <location>
            <begin position="811"/>
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            <begin position="835"/>
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            <begin position="902"/>
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        <location>
            <begin position="947"/>
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        <location>
            <begin position="1148"/>
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            <begin position="1342"/>
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            <begin position="1825"/>
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            <begin position="1980"/>
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        <location>
            <begin position="2226"/>
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            <begin position="2263"/>
            <end position="2277"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2458"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="2495"/>
            <end position="2512"/>
        </location>
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        <location>
            <begin position="2557"/>
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            <begin position="2580"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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        <location>
            <begin position="2653"/>
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    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="2770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY71316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2863" mass="304372" checksum="29CDCCC7254595C7" modified="2018-07-18" version="1">MSHRESSESPPPAAVSAPSRSPSLSSTSSSQTSPTQGARKVSPSSGASLPAYSAQRGSLAAGRLFPNVSAGSGVPLSSSPLSYGSSAEGRRRQDSISSSVSGTTDPTSVEESGSECMGPEPGSESAKERATASSSSQPTPIGSPSASSGLSLNRRYGAPTAISTQDLLSTSGLASGSTGSPLGPVASGSSAPSTSFPIPISTSIPSSSVRLSTTPLFPSPLAQASGPVEERHGGDDGESDIEEEDEDATGTWLDKSQGAQTGAQAQEPFGELEFSPPPANLELPDTSATNLSANVTPRPAARTRARASPNSNRDFSPEHDPSRTARAGRVRAPSARASGLSMVLNASDSEATPNRRRSRDFAGWSGLVPEPRSAGSSPSRSSSNSYDPMAISPPSPSSSSMSISPTSVSRRSSISFPRSFQPGSPTNARSLRASVGPLQSGMAIPQPFPAAPPPHESIKLQKVPESVRTALEFRQQSAAYNGEPMSMPETSSFGGRALASPFDVRVPKTPVATRAPSPASPLSGQSSPSPAGSRSASRHLSRQSSRDSLAPPGAVPIAGPSSSAASSAFAPLFPAAALNTPPITSSPRTRDRSRSVAMPSVASYGSPKSLSPPPKHLIVSNAVSPSGLSVSVLASSPLAQRMSLFDQEGAAPAGSRLSAHRMSLAPTSGLGGSGDGTDEYAQIILSTRNAKMRKWKASGLTVSTFEPGTIGSGKTLIQGRGGEDGSEEKEKDSGPPETREIEWVDWLDEYRRLKEAKLRADREGDLPEGTGKPASDEEGHSTEGEDKEAKKKAKPPRASTPSPPKRNESFQPAEPALAAAQKGKAKATTADFNPFESTSAPPTSRISQGFLTPNLPMRLDYFPLAALSEGVGKTSASDTFQPFPTPTPISSADSYDFAPLRSVTSTGGSSMSNYGSPGAKRKRNITKLGNKIDAWWSAVRTSFSGAVDEREARPRRTSTDQPRLARMPTLEAMPSRTSSHYLRPITPSTPSLRNAASASDLPSSNAPPSAGRTAYQSGYVPTGPLAPSARVDTHRRKPSPSGASSLGLDDSEVGAAGRARRNPHLSLNLGPEINSLAPRHRSPSPAPKAKDADSAASTNPPLADVGPQGQTSLPIRVPTSVMSPPEDPRLTPGHSPMWVATPALVPSEPTSSIHPRKSQTLPAPNRPKISREGQKSSFSMHTVRQQIRQRLASAKDNCDKELRRIISDISTYVETEMHRDVHTPLPPGLRQFGQVGELPTVERSRRRSRAGPVEYDDSGSELATGTSEGGMDEGSRNDSDGAETSIAPSRTKTPRGPPISPQGDRRRSSARAASPRRPSIVPRQRHLTSAPREGFLGERQARSPPGSTPSSRSASHSRPHSPMPPGSGHRRSGSQSPAFPASSPDLVDSIEVSDSAFIVLLQEIITIATEVLDTPITKLTKEPGACAEYISRVQRVGDAWSDNPELPCRGWYVQLLLAVAGLSRVVEWWEAEKGFWSFEEGVDDSGEPILFVAKPTAEDSPDSRTRGISIGSQPSPPIIAQKGVQPAWSPLGIDLGESAMATSPGAVHAREPSATAAEVDARSRVGDLHQAVDTIRAQTLLMELSLNGQLFQYLSSAWQDLVGMEPDDCLDMPISDFLYPDDAAVFAEATRQLEADDSHTVEVNFRLRVATASESSQDENPPEDLYEAMEGKGMLMLDGLTGGASHTMWVVRPAPIDEAVDEASQSLARYGLDGLHWRSATDPSLLIAPGRLMLDPILCRICERPTPAWFFEKHNETCNAVHRLEGDISDCNDRLREMLDTVEGLATSLLGNGHHDEVEYAGIPFEHSPSATPPNHPHSRRPSLTAHTAQDGSTSPSLRTRMVQQRVVDHVRDILQIAISVSTPSVTDDTGAVPIHEQRLLSPNSENNLSAVMRWQRPAADERALAQLIADTEDQIRFKLNSVNRLRNTILYAEKVRQEWEMKAHDAMAAMQQARELSRERGPSPLPFDSPQLQPLPAEESPRRIEALDLPRPNSQLRRRLSQPLNHLSPTLGPEDGSVASSSPGALVPMSPRIPAVVPSSRTRSSSIKDFKVIKPISKGAFGSVYLAKKITTGDYYAIKVLKKSDMVAKNQVTNVKAERMILMTQTDSEFVVKLFYTFQSKDYLYLVMEYLPGGDCAALVKNLGGLPEDWAKRYIAEVIVGLNHLHQAGIIHRDLKPDNLLIDSKGHLKLTDFGLSRIGLLGRQTQLPSLRDARRPSGFARHGSELSTASSPLQTPALPNQSQTGYFGNVPITDSFSLDTPSEGSGSSAPGSSHAARLTSPASASGSAQRLIGVAGPPGAAAETPQQHFVGTPDYLAPESILGVGMDAGVDWWALGVIAYEFLYGIPPFHDETPEKVFENILSRKLEWHEDVIEISSEAHDFIDRLLVSDPARRLGKKGAEEVKAHPFLEGVDWDNLLSQPVDFVPQVNDPESTDYFDPRGATGQEEDYKEKDGEAAADPAASGDTALADDPAIQQMQPLPTPFAADPAASARAPRDRSETEPTSHQHDDFGTFNFRNLTVLKQANDDVIRKLKDEQAMLRSSDALSPLKTSVRFPGGPSSPSSASISSIGGFDHGHSRQASSSQLSPNVQRIRARQPSISSGGSSLHQRRNSLPSRLRRGSLPNSVFAAERPRIPTDWQPSGGERRGSEQTVSSDSSSPPSTTTSLPPLQIPGARAPELPIVSSAPDAPAPISSSFGIASSPSPMSAAPAMSNHLATIDCLVAGRNPIVTKVLETMLKRLGCRVVVVPNGAEAILAAGGIPFDVLFLDLAMPVVDGEKAARMIKSTVNPSSSSPIVAVCSQPAAVDDAAGTLFAGILCKPIMKADLLAVLSHLGFKLEVKHDQDASVNSSPTIKEDRRSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3J8</accession>
    <name>A0A2S5B3J8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3J8"/>
    <dbReference type="STRING" id="741276.A0A2S5B3J8"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="137"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="431" mass="46502" checksum="107C44842A5B136E" modified="2018-07-18" version="1">MSEVDQTERVASTPDSTTLVHVDSSGSSGGAAETADDAGLRRRRRRSASSDASDAYIEDLLRPWRAQGAAPGGTKDGADAEAASSYSGTDQPAPGAKQGGDPPSLAGDSQEEPHEPHERDDAEDDAAAAGGRDPLAASAGEERMCRICFDGPDEELGKLFSPCLCRGTSRYVHTGCLESWRKASPNARAFWECQQCRYQYRLHRTSLARIVTSPLTVTLLTITSFLLLVYLAGFFANSLLAVVEHRRAASSGLFDDWFVSDHILVGEGIREAVAFVSHQLEESPLAAGHHFALNRALEGESDSSTAYRFIKPFVQRGGRATVQNVPPPFWAKAILHFTKGSALVGIVSVFYSFVATTFVTPIGRTLFRALRPAGGRRRGPTNGASISQLVIVSLIVVGIIKSIRQVYRGVKWFTKLVLSRVEDLVIEVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3K7</accession>
    <name>A0A2S5B3K7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3K7"/>
    <dbReference type="STRING" id="741276.A0A2S5B3K7"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="34"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="327" mass="35207" checksum="45AE8BF7F37DF1D1" modified="2018-07-18" version="1">MSGPGPLAARAAATSADSPAPETKLHDIENRWSAQIKVGGVPACVYQVEHEVNKTTCYIVAEEGKEFEVTWKHEKPAQTDECGRLRVDGTPIGGGITKRRLGDRDHYTWLGNYISATQIRPFVFAPIALTDDPSTAVTDKAVLIGLGSIQLDLHRIVVQEYTGYDQTYKDLTKGPLVDEKTKKARMSHTTGQVCSRYDKTLLELDGILEGEDAPEEEPVPAAGNGGASASASPSVEPGARGSSATGGKKNKKRKKIELTLADSSDEEDGSDLRAKVAKLEAENAKLRNAVKADPDGVRVEPEPGVKEEYNVKVTTENGKVVLDLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3M3</accession>
    <name>A0A2S5B3M3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Type 2A phosphatase activator TIP41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3M3"/>
    <dbReference type="STRING" id="741276.A0A2S5B3M3"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39475" checksum="0C234CBD768C857A" modified="2018-07-18" version="1">MPRHRLHDDPSRGQRQIALEGWTISSTKRPILSIPEADAASTDLDLALPEICFGNNALRIEHDQARFALEWNTLDMLRAVQKGQGWDAAAGSGAVRVAYADEWTRAQAASGSLGNMTVQKPFDWTYTTLHPGSTHTPPSAQPAEWRAAPPTHPGIPLASLARTDIPILFFDEIPLFEDELGDNGIANVTVRVRVNRESFFVLSRFALRIDNLLFRYYDVRTYHAFGSGEIIREIKGREAPYELLRNRLRGPGAAGRSPLPQSTACASPVPSRAGYSAAPSSTGLSSLRSGGALNGALPSEPSEDLTPLTDSNWVAGVLEELALADEMQHGLNLERTGQQSHASQGWEGKGRKLEILSLPQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B477</accession>
    <name>A0A2S5B477_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B477"/>
    <dbReference type="STRING" id="741276.A0A2S5B477"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="96"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="482" mass="53331" checksum="25900ABDF10B88A2" modified="2018-07-18" version="1">MGGGSGGGGLAVNATSILCWTILPNLFTNALVSLFYRLSPSSRPTIPPNASPQHLANAQRLAQSHHHRARIALVLGYLAYSVFSIYFAQSTGLEKNYYSLLGLPREAIEHDPSGVVKGHWRRLARRFHPDKVGKQGEAFFVRLRTGVETLESDHKRWAYERFGPEIHEWGAKLVTPREFLMTGALRSLAWWAFAFVSVFAFTFFRKSERQYSFWRYLSLFLCLSLELHLIVWSGESPTFSRLFPNRLTYEHVSLLRQIFISTSMAMSQLAPVLFPPAPDVSGPASEEDQVAAALRDADQLKPLLTRLTRLAATAEAELLALQQLELEPLVAAPGSDARSVRSELRRHMVRTFEDLQLKGSAETKALWSEAVRAGLGREEVQVQEKRRVGSASARGGDTKQERLDGRPGPVHEEASISAEAPQQGEARSSLVSPPPSPKITASVLKPTHGSDRLPDAPSKADLHLAPPADRFASRLPTPPPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4B8</accession>
    <name>A0A2S5B4B8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4B8"/>
    <dbReference type="OrthoDB" id="10575492at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="447" mass="49908" checksum="5E669D326A5A8924" modified="2018-07-18" version="1">MPHPEQRSGDHSAHFDPRTDRSLSVAECSTFCAIAGPASQMTVAAVIAQTYETLIRDRLPEAARAQLPRDDLRFGGLVGINVLRRHAELWPATRDERSFIPADLFDLGLPKRLVPLQVERHYLHAENGGDAQRKARVIGDGLQTWPSLLQAVQRRVDQAFAPGDRNLHSPSVDPVYRSFANLAAEPSVRHALGEGTHLLLPRCKLDETGWMNWSTPVQLYGVRDSLPDFHDKVPPEDVVSTQVFVPVLSPHGRSFVEVHTYAGKWLAIIALSTLVNAELRMGQLAADQATERTATLDKWAVALLELVILFRLHSEADDTIGYLNRVPPPLVSATWTSLGRTVHSVDETLYATIRDSLERRQLEGQAASDDYDTVSWGSFAECSSSLEGWIRATCKVDVPGLLGQRERYLRSICGEARIFFEYLNHEFRHETPGPYHPQARQATHASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4S5</accession>
    <name>A0A2S5B4S5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide VIIA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4S5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4S5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6529" checksum="D37989BC4C430D48" modified="2018-07-18" version="1">MAIAPITGMMKKHLLTNLSIGIGGGVVAGYAFWVGIHQRNVARRDQWYLELQKSRAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4V5</accession>
    <name>A0A2S5B4V5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5102</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4V5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4V5"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="355" mass="40418" checksum="6967386B714B7BF5" modified="2018-07-18" version="1">MSPIGSEPYVLWSKRPGWEDLEPVPQNDAPDSLVPIAYDEFYRDAMDTFRAIVAKQERSERTLEITKLIIQMNPGHYTVWKYRADTLLQMQTNLSAELDLLDQLVKHHLKSYQVWQHRRTIVLALDDPSRELDFTAKALALDAKNYHTWAYRQWVLLHFWSSAAGARSASEEQRTVWDGELAYADKLLEEDLRNNSAWNHRFFVAFESGMGGDCGDREIRYAKEKLAISPNNPSAWNYLRGTLKRLQRPLSTCSAFAKPLALNTPADLPAGEPPISDKAELPAWLAIEYLADAAAEDAAAVKASEADAEQRRSDKAKEAADLFRSLEEFDPIRRFYYEFCAKRAESLLTPVTVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Y8</accession>
    <name>A0A2S5B4Y8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Y8"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Y8"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="17"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="869" mass="93335" checksum="4E11D3F8ADE4CE82" modified="2018-07-18" version="1">MADDARARQALLYPQVEYVLLAEFDIDEGSTVKHQYPAPTGTDEHLLAEHMLPDGAHDRPEDWTVFFLGQVPALETDSSLSAQARARVDIKGKGRADEGIKPTEDAGLLYVLSLVRTKKDASGRPGQVARDRHAQPVHPTLQGESAQSQAQKKPRELILSNQQPLLLLALEDYFNNPSVSVLAALYDSLNAIDTTGLPWLSLHERQILRTSDRKDLFEERFPVPSGSGSGSGSASTTNLHGRSPSTQSVATHSGISSTGEHSDLPFRTRSTTSFSSTSHAQEFLRGAQSVESLASHLRDPTHSPSIGTSASASRDDLSLSTSPNLSRAATMNSLEDDAGARPTAHLYRPSGSGADPLPRSPSLTFSQTSPTLASRELGPGGRPKDTHFFETKVVYNGLSLPVKVPLSTFPAEIGDYSLVKLVQTFSSPTALVPGPHHPHLHTAGAQTPAVIVLLNAILTGQRVVFLGHGQPAGRVAELVLAASALASGCGTVLQGIENRVFPYTNLSNLDNLQNVPGFIAGVCNPAFADRPSWWDVLCNIETGRVTVSRDLKPSPAPAAVHSILHRSSKRAASGSHIVGDGVDEHGMLNGSGAGADKLDPKADATDVAFMQEIMGAIQSHYGESIIRARFTDYIQRFVRIASRYEEETASATTIGFPCAAYNPAAPAAGYGAQASLGTGVVFADEATGVRELVANAARIERWMQTASYRLYQRDSPLPGIDLTHQLSRLRLTRHMSTSEATLLFATLADSTQTDEQIHALLAQLPSHQGGLLPLAFGFFHASAEVRHYTLELFDNLASHPTGAKFISSLNAFQRLAYARLASEREAQAERQTEEERLRGPRQRDTTITLESFARSGDGAGSPPPVPFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Y9</accession>
    <name>A0A2S5B4Y9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Y9"/>
    <dbReference type="OrthoDB" id="2533752at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="736" mass="80093" checksum="E8EBF4FC52982459" modified="2018-07-18" version="1">MSAASSRISQQRVVTGGERYVELVKRLQRDEQRLEEKRARDEKRGKQSTKSYTLSGIAGIAYRDVTLGRSAPTRSRVALDAADYLVRRERAREIEPATLDTVPPLADVCLRVLAASYGEPGVLDALDPIRHRDYVPRLLDSIEAAARRDGDAEAAEPGNATLPFQTWLDVTSRCAADTPTSRKTYRGLVVSDSAELRVLKELNQDSEPRYLQALSSASLAESKPPPPAFFLAYLDLSSVTSFGDGDIYKLRDPLSHFLATLRLDGTAVTGGGLEWIARAARDKPQYQQLAILRLRGLRQVTDAAVVPVAANLANLRVLDVRGSGCTAAVGTQINRAMAQDRLGTTKPRLNFFRRPNEVRKGVEKLPSTGATISVHIELEVFDPSNFSPAHAIAILHYLGAEERSESKPLSTFKPLGVDLNALTRAPATGTSAANTPKTAEQVYEAQIALQAKLSHAAHHATYGGLTSTVALSRDAIAESGSKEPGERGAAFRVRNDAVMGGKSGGDVAPAGSLYAAGLKRVHPDGKGKWTPHDRDAYSDDETEANEEAAYVAAETAAIEAKQREDEESALFYRYRLIGQDQREIKRRGERTFAIPPREDGMLIRFMPYVSPWEHKELESAAAPAGTQELARELQKRRQGDARTGGPSTPALVKKRRRDENAPELLPMASDTQPQRTAHSSSPASLPFFGPSSSASPRGKPASQADRSLFTPRSDPKNLVKTGKALPKRSSLAAFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Z7</accession>
    <name>A0A2S5B4Z7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Z7"/>
    <dbReference type="OrthoDB" id="4160064at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="138" mass="14297" checksum="62507A37FC82958D" modified="2018-07-18" version="1">MDIPVATLSILHITVGASALVAPSFTAAFFGLVPEPGSILVTRLFGSRDLALGLALYRAFRSTSSRPRPPVASPGVRVPRILSEAQKGALWIANLVNGIDVLSSLVCYFEGNIGVAGLLWGGPGAAFLLGLGLLGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5E3</accession>
    <name>A0A2S5B5E3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY72000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B5E3"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="937"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="973"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1368"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1368"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1507" mass="163385" checksum="ED3BE82EF7F0A300" modified="2018-07-18" version="1">MPRPVASALRRATSGQSPAQPLAPLPTCTCTHPPASRNASTHAAVSACAPPPPPPDAIEPLVTGTGGFGFFSRSLPKRRSPRPLYSASDYAARGTPVSPTQSPSAWILHAPPQFPTTDLPVPSPSSSSSSRRLPSLSAPPPPPPVPQSEPFDVRNWTPANQSTSSSRATASSFSAAPTAAPAAATLVSSSRRARLVVPATAQCVCGRVQMSCLRCRASSSSSAAAAAALSRARPKAYVEDRDGLDTIKSTAEALDPIPKIAERDSETRTSGERKRPSGRRRRPSDPAELPEEASARLAALLHRHAPKSLPNLRGTTVVSSHPQRGSRYLSLAEASASLAALKQEAQDEAFFARLSVHEKLDLVRAVSTIARAVLAFPPTQLLPSTDDVAASPSAEGDERSRFELRHAAAAEMRALLARSGLDKLEAVGESASSKTRSSAALLIVDAATLADDVVQLAESLASKSPAGRSRLATALRTLFAPPPVRANDTISVLEASTRETNRRQNAHVALALVLDTLERNPHSEASDSYSSASTALRLLYDTGAHELLDFVLPSSLAAAQQKQRAHNDVLRRRYGMILGRLEPTPSQWFQKEAFGTEGKSGDRRAGASLGLHLIRYLARAGSAGEAFAVWQALDRGVDVESSSVASELNDLERLEALSHLVDGLAMERLFADANTLAGELEDLARAVQIGGIGEESQGDAAIEPKSTTPSPLVPAAYRALARLASGQGRTPILERLLSRLATVSDGPAASGGQSLEAAARRMRARSRRYEVDEVRAIFDSADLDSALPEERARLWGQLIAAYVRVNDVEGGLRELQNMLSTGLYVPLSTIDVVLHGFARRGDVKRTSELFSRLAEGEFPRLQPSASSWNALLLAHSVAKDPTVVEGLVTEMRLAGCRPNRQTWTTLLSTYVENGQWVPAFRVYRLLQSQSDPAQRPDTAVYNIMLKACILTGTPAKTVVDLFRELIARGIRPNMRTYTLVLQSVCIAGMMDIAEELFLLMDRRQDSPDRPPGMSVIEPDQFVFSTLVAGYLRRGEPAKARAMLHEMTARGIKTSSIAVGVIIAARIDALQQREGRITGSSMQHVIQQARDFLETGTSGEKGGLEGRRRRQPVRFDRPLALGKEAAVVYAPILRSLAKQGNVAASLELFEEILDRQDARGVPPIELYTTVMDAFRQQELEVASPRETDRLARHVHTIWGQLYDSVCDRFVRLRPVEDSRASVGPPLPKFSRRVDPAQIGILRLPFTILLDVASRAGNGALIEETWRRLVQQGFAFDASNWNALALWFTRDLQLEKAMWITEHVLCKPTDDADRDADRLGETFAAELGAAESLTTNGRTPSRVWSQTQAIAAPARTGSLDLSFLSSRAGDGRSEQVEQDRVEVAEAAEPVDRERDQQQKDVSTAFSTGIARQATLAYMPYRRTLETLETALDVFTTSGTLRSEAALTAAASAVADVPGNGLSTLSFEEAQAEYRRLVQAHPHTMRSIEALRARRHRVELDRHERSKGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5J0</accession>
    <name>A0A2S5B5J0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY72005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5J0"/>
    <dbReference type="STRING" id="741276.A0A2S5B5J0"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44368" checksum="C46B03E2DB00715A" modified="2018-07-18" version="1">MAPPSANNSSRGFATRSIHSDATLSGPEVAPNISLSTTFRQPSPQEIASKPPGYYDDSKFDLSDPTRDIYSRYTQPTLTRVERVLSSVIGQPTLVYPSGIAAFFACLLHVQPDVVAISDGYHGCHTSLEVYRKIKSTITVIGLDDEYPKHKKTLVWLETPLNPTGESRSIAHYSQRAKAANATLGIDSTFGPPPLQDPFQWGADIVMHSGTKYFAGHSDALVGTVSVKSKQAWNDLWHNRTYVGSNIGSLDAWLLLRSLRTLEVRVRKQSDTATRLAQWLATLTRAERGTTLDGPGGVVKQVWHTSLQDNRAELLGEGKQMKSGPATFAFLLENETYATHLPHNVELFVPATSLGSVESLMEHRLSSDKRADPRLVRVSIGLEDFEDLKADLIRGFNKVIKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B601</accession>
    <name>A0A2S5B601_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate-binding module family 13 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000056">
        <property type="protein sequence ID" value="POY72197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B601"/>
    <dbReference type="STRING" id="741276.A0A2S5B601"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015641673" description="Carbohydrate-binding module family 13 protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30892" checksum="609D1172943EC0CA" modified="2018-07-18" version="1">MKSLLSSLVLALVAVHSTSTSLAANVDPNNLPHKSEAGQYGYNDCGKYGDSPKAKCQTLWINSLSDFCLYAPPKTATIGDSERYEVAWCTKAGHGARLIPAGALKSAHFVKTPKYIQITGTGDFTKMKIAKGDDGGELDPHGADGNGNPIGAVVLTTAFSGRLEQVHEWHQFIGANEFCIRICRNDNPDNWKWCNHIYDTEGCYWNDPGRYGSGFDTCAADTVVMPPGEYKLSNGHTSTFYHGQQPTPTAHAPAKSSQCVKQQTIKAAKYPAATRKVKVKARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B642</accession>
    <name>A0A2S5B642_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dephospho-CoA kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B642"/>
    <dbReference type="STRING" id="741276.A0A2S5B642"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000991">
        <property type="entry name" value="Dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28501" checksum="B48C1BE2CC68F0A7" modified="2018-07-18" version="1">MLVVGLTGGIASGKSTVSKQLQAHGVPVIDLDVLARVAVEPDSYALSALVAHFGQQILKPDGTLNREKLGSIVFGNERERKVLNSIVHPAVRRLLAWELVKAWIRGEKVCVVDAPLLIEAGLWRMCGAIVVVYCSEILQLQRLRSRNDLSLADAQARLSSQAPLSSKLKYADYVIDNSGPIADLSAQVDRVVDRLHRRAGWSWIVSWLVPPVGIIRAALRVGWRLYFQRVGKDKGRSTRGEKKPEEIELRDRKSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6C1</accession>
    <name>A0A2S5B6C1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6C1"/>
    <dbReference type="STRING" id="741276.A0A2S5B6C1"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="133"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="477" mass="51247" checksum="54ACBC7EAA837711" modified="2018-07-18" version="1">MEVYLASTKPGHDPAHASGRGASLKPADPSTSRPRAASVNPAQGKQRPYESLTEAPKASATLTGNNLVQGGLRERNHAIIKTLGKEDNPITNSTAYSRTMHIQSCATGHQSGGGGQRWTLHRNAKLRMQAAEAESQALKGVIAYINGYTGRDMTNTQLKELVERQGGSFVTMCSARVTHIFVTENLSAKKAQHYLEARRKNGTKLVTPEWAIACAEKGKRVSEAKFAAPVFNEMQQSTYKLFAKDQGGSVAPSSETTIAVAGPSTASSTRRTPTRSTSSTSNESGTTPEPTAGLLPSAQISPRRSPRNHASSVSNPVQASTPAPTSATALLLEQIKAAKAQRSPSRSPNSKDAERKRGWCATWECVVESPGRKRQRAAASVAATVSETKDEKENKTASIAKTRGRRPTSSTSPKKEEVLVLGSSDTEEEARPKATSKTRPLQPSLSWASLSEDDPRRPDLTADEDEEWSLPPSAQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6G7</accession>
    <name>A0A2S5B6G7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">chitin deacetylase</fullName>
            <ecNumber evidence="9">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6G7"/>
    <dbReference type="STRING" id="741276.A0A2S5B6G7"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015472705" description="chitin deacetylase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="12">
        <location>
            <begin position="144"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="452" mass="48068" checksum="CCC74E6AA482ABA1" modified="2018-07-18" version="1">MKSTVANALAVLSTAAVVAVSACGTEREFAVIRRDAIARRQAAAARPTDVASEQQITDPAQECAIYNYPPVASLLAQKVFPPIWQIANLSTANSEAVSLFQSLNGSIPNIAPRGTPTGNFTGVNYNGVEDPDCWWTWKQCHTPKVAGIPPDIYNIPEPNTWGHNAFYDYLYQQKQKATLFYIGSNVMDWPLQAQRGISDGHEICAHTWSHHMTSLTNEQVFAELYYSKKAIKDVMGMTVQCWRPPYGDVDDRVRYIAQALGMRTIIWSDNTFDYQVSTLGAAAVEANYQTVINGGKNGTYNSNGTIVLTHELNNDTMSIMVQNYASIKAAFSHVAPIHVALNSTMPYVETGYTYPNFAQWTAGTTSISLASPTAASSDITLAIPLSSGASGSISASVAHSTAGSAQAAAASASETAKAHSGAGSNRLTEGPIGAVVAAVVGALGAGAMVVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6J0</accession>
    <name>A0A2S5B6J0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6J0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6J0"/>
    <dbReference type="OrthoDB" id="2548929at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1202" mass="126639" checksum="AF98C488B2625FF4" modified="2018-07-18" version="1">MPRLALTYAHAIVREYWTAAAALVGICILGESICTSRRPWLEATEAARELPSRSGKTGGTRADADPAIHGATARAGGPARRSRGTFGVIARQRQPAGHLQHLAHLSAETDVFWIHPTDSLCLIGLAVLARHVATLTAYLTNPDPASFRTHLTSLSFHTHMRRLSSPSRSRSSDVDAATGDSAASSAVNGNARSDAAGASGAAKRKGAANSGGNSADPRPFPQSPKPLANRHILSFSNRISLSIRTPSYKFTSYHLFSTVYVPSSRPHRAIPGVKKQQQLAAQRNHPEMSALLGLGGELWFGAFGRWFALRWWDSEDAEEEERRGRLDKGIREMVVEDDEPADGSTYASANSASASGASTPSHPLPHALSSLSDSRSATSTANDLSASAKNVPPNSRLSKRVFRAGQRRPSPTSLTRLKTKAEHAAREALEAEQRSVREPARSASKDRSAGAIAVGSGGGDDKSRSAGGGGANGGHVLLGGSAATDPVLLELQAQLDELRATAAESERRLQDELEVLRGKKRDEDAFRAELKVKTKGLEEAKRAADVRRAEAEKELNERKAVVKEAQSRVDKLRDEIRAIERKGLEAVERKEKKQRERKEREKKLRDDVGKKRTELKEKEQGLEEVMQKVSDMERKLEVRRALLAGRRNELAHYAQQGMRAANHVLPQQAMPPNAAATSMYGPVPTGQAAAPSLPATATLGGVGAFASAFAAPFGQGAYGRRNYPYVHPLSANNSRPTSIRSGHFDPLTGAFQSAPSSPTLAPSTVPFDDHSPYSAGAAVDPASGWPTSFASGPNGAPHSLPHAGFLEHRLQHRAAHDDDGHPQYLAFEGRTLGDLAEVSPSLSDFPNGDPIGIDGAAEDGDLTRLRNLALPMQYLESGLLAGGAETPGPDGPLSPMTPHQTSLIPSQLFHLLDDDEDEDGLFNMPDSPTLRGALGPDNAADWQGLGLDVNRPIKPMQPRTNSHDSVTADSPQEPHAPALAALRQESDSKGTASATTSPVGPPPTSPFTAWAADPSPPATSKQESPSLAHPSAPMNGFASLSSAPGAHLTHRMSPSLDLDDDLPRAGLSLNPDAKAFAFSSMAPGGLIRTSSPGPGGARPNRLSFPGSNQASPTAPASPSPLANTVGTIGNGAALASGGPFSSRLSPANDWPSSSTSAMLPSTAAVVAPIGSGLGPAAAVSKPMATGGFNPFGAEDDLLGPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6R7</accession>
    <name>A0A2S5B6R7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6R7"/>
    <dbReference type="STRING" id="741276.A0A2S5B6R7"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015521533" evidence="7">
        <location>
            <begin position="21"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="357" mass="39765" checksum="141717A1A18F4298" modified="2018-07-18" version="1">MNALVLGVLTAAALAVPAHAQPQNTAFAPDGSLILAGFIPSLALGVVALVLFLLSSIALWVHWARTLRRRYMLTLTISMVCMFLGFVFRLAYRSNYTSLGLYIIQYMFVLLSPCAFLAMDYMLLARLAQAMGDEAVHCLILPATRIAKIFIWSDVCTFALQACGGGMSTSHSPDSQRIGPKITLAGLAIQLASFIFFTVTLLIFGFRLLRRPAYSHPPQPFTFKNYKFWSSSRIHDWRPIFFVIALTCIGILVRSVFRLIEFSQGYYGYLAVHEGYFYGLDALPLWLAMTLYCFFWPVRFIDGARDVYCPAVADATNGVMVRDEESLEKIGQNSHELDSLGPSADGTLPMSTRDRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6S6</accession>
    <name>A0A2S5B6S6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_4292</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6S6"/>
    <dbReference type="STRING" id="741276.A0A2S5B6S6"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="98"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="295"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="449"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY72466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="719" mass="75596" checksum="D5051E9CCF36F1B5" modified="2018-07-18" version="1">MPPLRDPNRLWYDPSKPRMLTSEEMARMSPAELQAAIDQIDQLQIRSLRGIDEEFDRGNRIILDEIIPLVEQYGENSAKIYESIKWIKPLMESAASTRLDARPGVDSTTASDAPGDLSHDGSLASPDRTVNSAGDISHATEGSVDGTPRAFKQAQRTGDDGQSSAGPQWSNDMSPFQSVQADLDGGKGITGDYSAMRKNLPDAQRIRLRDLPPDSPDTPQFETMTLRHTGPGTKAASAAHDLHDNSLSTAEPSFSTAVPDTPGSAVPRPRTAAPPGTDRAAHSALLNKVLRKGIDSPSLAKASPARAGPSRGGPAAQQSRQQLPADIPKNWDGIADLSTRGLTAFASPMKQPSSSAAVGRAGPGPSSSRHLMSSPGVALLNASTSTLRRFPASPAPSAALSRTPAKEAARRIAQSVYDATGNFDSPDLPSALKNANSTRLFDFAAHDRAHERPGADSPSQNRSMAAGGSRARVPGSAVQGNESFASLPSQPSFIQRSPTQLFHLQEHESPLSSPAAQPGRTALADFGGGTTANIDELLASASVRYDPADVSLRQSDAAPNFAGIVDDDDGRQPYNKSHDRLDDSFTGEAEAGYVPQRGDEPTFTDFDAAYAQATGRGALRLPGQDGPEDTLFGMPAGRSAATGGAPGPNANATGKRVAYAVEEESDDTFTDDQARAGAAAGGRSGFRLHGVDDMATLHGGELLSSEPFQASPLAQKSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B707</accession>
    <name>A0A2S5B707_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_4373</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B707"/>
    <dbReference type="STRING" id="741276.A0A2S5B707"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY72547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="325" mass="34400" checksum="C2006C019D213616" modified="2018-07-18" version="1">MPGESHLSVSRPGSATPASQVPSDPIHAHLLAGAGTAADLTTPPVTGAPAQATPKATAPVDGQQSSKTANALAARRESVTVEDYAKAKDDGKDKGAAAASEEVKLREFVQDDGHFSLVRNFRLADVVTLGNGFCGALSLFSAAHYMITRDEKYLWHALSYPVAGFIFDALDGKVARWRQESSMLGQELDSLADSISFGVAPAFAAFTLGLRTPLDTLALLVFICSGIARLARFNATVALVPKDKTGKSKYFEGLPIPSSLLMVAGMAVCVSRNRFEGPHGQGQGLPWGIIEPVKDVLGLELHWVALLPLGWAAAMISKTLRIPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7P1</accession>
    <name>A0A2S5B7P1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7P1"/>
    <dbReference type="STRING" id="741276.A0A2S5B7P1"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="160" mass="17741" checksum="0D0F887D1CAA545B" modified="2018-07-18" version="1">MDGLWNKLSGSETAAVVDNMTTGDDSAFKFLDLTRTQRLYGFGCCLIAGFAMSLIGAIFFTLGQITLFALLYVIGVICSLVGTGFLLGFKKQFKMMLDPVRIYAAGIFLLCIALTFVFAFAIEIDVLVIVFAVATYVSYAWYSLSYIPYARALARKLWPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8L4</accession>
    <name>A0A2S5B8L4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000041">
        <property type="protein sequence ID" value="POY73105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8L4"/>
    <dbReference type="STRING" id="741276.A0A2S5B8L4"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019488">
        <property type="entry name" value="Nucl_pore_RNA_shuttling_Mtr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10429">
        <property type="entry name" value="Mtr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="160" mass="17015" checksum="251A7748528721EC" modified="2018-07-18" version="1">MTVTQAPSSIEAIVANSTRVAEAFVNRYYAAQDLEPMERPAPVQQLYAPTARVTWNGNPIAYGDLPAFVQQMPKSAHEVQAFDCHPISGSANGASPPSLVVTVSGQVAHGPNPTPSAGSINSKNFDQLPRVFSQSFILVYVGPGQGEDGYAIASDSFRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8M6</accession>
    <name>A0A2S5B8M6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_3825</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8M6"/>
    <dbReference type="STRING" id="741276.A0A2S5B8M6"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="162"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY73132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="703" mass="76749" checksum="F48A00D25557E9F6" modified="2018-07-18" version="1">MHRVPRLLYRRVASPRFYSALDSPRPTFARVARLDFSHNMATDAARPLAADSGATSSSQVMQVDSPAAPAQPADERAQQQQEQQEEREVPEGFVVHTESTTSILFAAPAAASSASGTAPVFLNPVQEYNRDLSVVAIRTWSELRQDEKRKYWEEGLRRKWARKRARDTNGTDGGDKYGKGKGKEVESTAAEGEEQRPKRRKDEGGQAAAVVPEGEGAAAGESSEPVKQEEGQLPKPPTYKFSLLEALSATGLRAIRYAKELPLLRYVIANDLSASAVEDIRRNIAYNGLAPKGLQSLEGTAGLSEDEIKPGQQWSKADIEEAKLGKVRANEGDACVFMYQHRSEDARFDCVDLDPYGSAVPFLDAAMNAIADGGLMCVTCTDMGVLAGHNYPEKAFTHYGGVCVNAEYSHEVGLRLVLHALAATAAKYGRYIEPQLSLSIDFYVRLFIRVRTAPKEVKALASKTSLVYYCHTCQSPHWQSFGRVQERAGKNGNVNLTYHVPAGPPEEVKGDRCSECGGKFHVGGPMWAAPLHNKAFVQSMLSHVSDNAKDFKTSDRIKGMLTVALAECEAPLYFSPSKMASLFNATCPPISTFGSALLNGGYEISRSHAVAGSIKTNAPRTFVHDVIREWIKSNPVMMKNVKDGSPAKVLLAKEQTHEVSLAHNPKVAEALLDNIKLVRYQINPQANWGPARAAIRGAPPPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9A5</accession>
    <name>A0A2S5B9A5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9A5"/>
    <dbReference type="STRING" id="741276.A0A2S5B9A5"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="834" mass="91028" checksum="9CB408B474E463F3" modified="2018-07-18" version="1">MARRGDPDPVDRFGAAADLASGLGIRAGPSATSAVPRPRTEPPPSRPVSYYATPPEMSRSAANGYATAGPSSGARNAPAPYSHQAYTLGGPTPSTSAWSSVSSLLPRSPSSSSFASMSPSMERSRSTGSDSHSRQQSLTSACAPVTSTHLGAPPPQGDAYSPRSSAESRNGHRRSHDWGMEAEKAYVSDDDVREGAKRRIPERAGPVDWILDAPGALLSYLTRPLRATIPPNRLLTTSPALHATVPPMTGKKKSPLPIRLAIIAYLAFSFLYLTFSLPSYLFSSASRTDKDGNVSTRLGAEPGAAGWQVVRDYADGLGAKAGIDLPWLKPSDGASTSAAKPATDADVELSVEGWGKVQRIGNPDDADKADLSPQSNPLTPFTHTYRFSKMHDKVHWDLHDEIIPFAFSATAKVSSNDATALMYSNDAWLDTLPPFVKAWRGPVSLVYETAHSRHDTARRTALLSAIKALRDANPLVKQFVDFHILGVPTSMSERSIDKARERMIRQPFARNFHLNLARFFASTDVIFLAGDARITPSGGLRRRLTEAKAREIMLERGDALVVPMFGFLRDAVGEPSRIATTGQLREQLGLSTTGDAYAGVRDDEFEAIAAQHLGQLYESLPIAPEDWPNRKQTLVQLANTRSPTVSTQTVPQLALFDRRWEPNRGPSNWYLWRKSSADPRLNDEPAAGGGVGLGLDGKLGGGREPYKVVDYDLHYAPLVAMSRKGHPWCTERFDELRAACTYQMFLSGAEMYVLPEDWAFTLEVLEKNPTGYREDPAEKLKNSISSRLYGKFHQEACMHYGREFLSVGMWDSDKAQHLRETCTRTLGTWGMGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9M2</accession>
    <name>A0A2S5B9M2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative Acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="15">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_3412</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="15"/>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9M2"/>
    <dbReference type="STRING" id="741276.A0A2S5B9M2"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="38"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="302"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY73475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="425" mass="44047" checksum="AFB7EB6E5DD8F24D" modified="2018-07-18" version="1">MSFASSAKDRLTGLVSQLASPNVGGGKAALLAQNPNDVVIVAACRTPITRARKGGLKDTCPEELLKIVFEDVVKRAGVDKNLVEEIQVGNVLPPGGGATMARMAQLAAGFPTTSSVATVNRQCSSGLVAVNHIALMIADGQIDMGIGAGVESMTQNYGAGVMPEKMSENVLANPQAADCLLPMGLTSENVAAAYNVTREKQDAFAAESQQRAFRAQAAGKFKEEITPVHTKVIDPATQEEKSVVIDADDGIRDGVTKETLSKLKPAFSKTGSTHAGNASQVSDGAAAVLLTRRSKAQELGLPILGKFVMTSVTGVEPKLMGIGPAFAIPKVLARAGISKDDVDLYELNEAFASQAVMSIEHIGLDTRKVNPNGGAIALGHPLGCTGARQIATALAEAKRSRARIICTSMCIGSGMGAASLIVAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9P8</accession>
    <name>A0A2S5B9P8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9P8"/>
    <dbReference type="STRING" id="741276.A0A2S5B9P8"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="767" mass="83776" checksum="45B4617137F745E7" modified="2018-07-18" version="1">MVDCTKVSSESCCRDEKSERGREKCFSSLARPSEPEQLAPCRTGSESLRYRRVLGKGRLGDARRMRARLPRLASVAVPSPSHHQPPAARDHSWPAPSSRDRPTGSEHALGLYASSERAKDWPRSARRAGQVDQLVTSSSGSASTSAQDGSLQLREAPESSGSRQRHPQSFPFAGKPSPVRRPTFVQTGATLEAGTGSSREPSTSKRDSRSEPAASKSSGVAPRRTITSHLESLSLPVTEPELYQFLRQTKAAYTSLPVEWLTSFHSHGNLAHLVSSRTYRFLLRAAFGISDLRLVRALLAEIKDRGIRIDDATSRTVLRGYAALGPRLRREDEAVRTALMEELGEAGSAVARPTRRRNFGESGKGLNDLDELWKGWTVRGRDSRLRDQLEGLLSSPRSGPEAGPASPATKRSKVGSSSPRAKANLRNAEPASSPMRRIALSRPPTLIPPLAHTLPGPAVAALTQALVSDRRKDDALGIAESWLAANRLVLEPPSSKKPPDPPPALEPAPLLTDRAAGGFRPAALSSYLRQAAAYHSTAVVLLNILLKPLFLERAPLPVIRTFVASFVRTHSAARPAPPLVPDIVTLRTLVAGVLGTPTAWDRATSLVDWFGYQWGIPLADPCSNARHRFLPPPDVEAERLEVAPRSAGAGSVLNSLVVDERQPRSHVDVNLLLVKPHAVVSPDVALLLLRHAADQYSRGLHAQSASRRRVWRQSIRAWWRSFYKDDATTDVWTGQKARSVVRRAVKAGMFKPKELIRGSTRDVEQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9W6</accession>
    <name>A0A2S5B9W6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9W6"/>
    <dbReference type="STRING" id="741276.A0A2S5B9W6"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005732">
        <property type="entry name" value="PRK07550.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="38"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="399" mass="44075" checksum="94845AB67E48FDB2" modified="2018-07-18" version="1">MQEARYQLSGRVRASAAPPIPLAAQWAAEYSPTAADPLINLSQGVPGAPPPQAMLDKLADATRDPTTTGYGALAGDASLRLAVADNVERVYGPPAQEDFRVTADNAFYATMLALAEPGDEIILPTPWYFNHQMSLEQLGLSLVPLPCHAPDFLPSPKDCIDLISDRTRAIVLVSPNNPTGAIYPRELISRFAVLAQARNIALILDETYRDFVDGPPHHLFAKTDWPAYLIHLFSFSKSYAIPGHRLGGLIASRTFLAQVSKLLDCIQICPARPAQRVVEWAIGAMSDWRDGVKHELQSRQNVFRELLEGVDGWEVATGGAYFAYVKHPFEGVPSQKVSQYLAARVGIITLPGTFFSPPFDRIDEDRYIRFSIANVDEATLRRVPARLKRLNELWPTLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9Y9</accession>
    <name>A0A2S5B9Y9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9Y9"/>
    <dbReference type="STRING" id="741276.A0A2S5B9Y9"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="347" mass="38142" checksum="CB03ADA0587A6D06" modified="2018-07-18" version="1">MSAPPDIQEKIAAARREAELLKEKIRAKREQLADTSLRAMANDVEPLPRIAMRVRRTLKGHLAKIYAMHWAQDKRHLVSASQDGKLIVWDAYTSNKVHAIPLRSSWVMTCAYSPSGNFVACGGLDNICSIYNLRSREGTVKVARELSAHTGYLSCCRFLNDRQILTSSGDMSCMLWDIDAGVRVIEFNDHTGDVMSLSVGPNQNVFVSGACDTTAKVWDIRTGKAVQTFTGHESDINAVSFFPSGNAFATGSDDASCRLFDLRADRELNQYTHDNVLCGITSVGFSASGRLLFAGYDDFNVNVWDTLRGERVGVLAGHENRVSCLGVSADGMALCTGSWDSMLKIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA45</accession>
    <name>A0A2S5BA45_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA45"/>
    <dbReference type="STRING" id="741276.A0A2S5BA45"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="182" mass="19218" checksum="74DEE8AC003402C8" modified="2018-07-18" version="1">MSGYEQPRDDLDVTLPPRPFLAPLGQPMPKAYHPTSPFAPAFNAGLTGAGVGLFVSAIQNSLQQHNKGAMGVFTRTGWMIGYFASAGFVFSYVDNTVANMIENKQNGIAGAAGGCAAGFVAGLRSGSLPKAMGMCAFTGSLVGTYDLTGGQLGWESGKKPRNEREKERVAFFKQRGEATEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAA5</accession>
    <name>A0A2S5BAA5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAA5"/>
    <dbReference type="STRING" id="741276.A0A2S5BAA5"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="153"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="613"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="206"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="704"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="764"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="922" mass="99413" checksum="ED009521C7BF7261" modified="2018-07-18" version="1">MELPATHLRLPASLPYPLTVQRIHAQVDSQIRKTQRLFTYSFLPTKPDEQGRRERQVREWDSPIQGQVVHWDVREGDIIREPRAVVKIQEPCTHDVQLNGLCAICGKDLTATDYTGFSDTSRATISMVHDVGGLTVSREEAHRLESATATRLLKAKKLSLIVDLDQTIVHATVDPTVGEWLQDPKNPNYKALEGVQRFKLLDEMPMRRPKRSRTTTGTTTPGLVTPLPTPGLSESGTTEDGESVDDEDDLPGCWYYIKMRPGLPDFLKRVAEMYEMHVYTMGTRAYAIEVCKVIDPDGGLFGGRILSRDESGSMTRKSLQRLFPCDTNMVVIIDDRADVWDGSPNLVKVIPYEFFVGIGDINAAFLPKKKELVPPPVVPLASPTLAETTAESESEGSASPLETALSSSGATPDTRSTTPPTSPPPGPPLSPIQTATSNAAAEAAVHHLHLPDEILSEPTRISDLVVSSSPDQVVSPSMAEAAVHAKETIHDLIEARPLEKARREADALHHLQHPPSPKSPSRPPLSPSPVLGAGVPGDVLVDDAGATSATVEEAILVGAEQDDDSEYEEEPVLKDDDRELDRLFEILSSVREKFYEEEERRGVSDVADIIPGMKAQALRDTHLVFSGLVALGSRPEDSEYWKLATTFGARCSADLTSSVTHLVANQAGTAKVHSARRNPRVKVVYPQWLLDSVARWVRLDEQPYLLPPPEDRLSTPGSPIRPELSDGESDAKTTGTADVVEADLDLGDLDWGDAMKEVDDLLLETDDDDDGASSVNGGGDTTDGESDNGGAARSAAVGGRKRPRISSTPSDTSNGSTTAAAESPLQKRVKTARSRRSGLKTSMSAAEGDALVQQSDKSSTSSTAPAPRSRPPSPLRPSNGSVASNPAADADENGVDASQASSSISSDDEDLLAMAADLESGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAL6</accession>
    <name>A0A2S5BAL6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAL6"/>
    <dbReference type="STRING" id="741276.A0A2S5BAL6"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="8">
        <location>
            <begin position="136"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="670"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="459"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="700" mass="73010" checksum="5922CB78D00D5449" modified="2018-07-18" version="1">MAEDIAEPTFTSDAAAIAHYRQLCASLQSQLAAAEQDILEFTESSKDLQAELESELERMDKAEKGMRKELDDTKNEKDEWKGKYTTALRDHTSTITHMQRELETLRATEKQLRTRLRDMELDNDDLEKSEREKDSSLQDLETRYNKSLERIALLEEELVAKAQLEEEVQRLKDDLRDVNEELVVTRSQAQAVSEALAARKTATVVQPAPPSPPRSEPPETEQTVSTPRRAPSPASSPPPSIELVKPTPATKARPRPTSMIASPPTSISPSKIARPPSSALPFPSPSPTGQTPFRAPLGRSTRTAHLQSYGLPASPSSPALASPSRSRVPSRTGSGLGASTSSASATSGIPRTDTATMIRDMQQMTSRVRQLTQRLDHRRSSVMRGSAIPRIGSPSTANIAGLARGDGADSPTAMASSTMGRSRSGLSSVGGTSTRPASSVGAPRPPSRLGERDSTRPPSRSAALRASIASSMAASAAARNAAAVGAADSTRPSRPSSRMSTASGTSVASYGASNGRPMTPGAGPARSVTPSAGRHHYDGSRPASSLSSSSAAAGGSSYPARPGSSLGRSTLSRSVAGTANGHGRTGSASLVGGAVSRSGRATPSSYGGEQEDDDLRATVRRAPAAAVGTPSVAGNRRASGIGLPGQSALGRGVGLGRRASLAGTRAVSGRYEHGGAGVGERDEVPPVPPLPLQSRTGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAM2</accession>
    <name>A0A2S5BAM2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAM2"/>
    <dbReference type="STRING" id="741276.A0A2S5BAM2"/>
    <dbReference type="OrthoDB" id="2528138at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="67850" checksum="1A23A86F9FD043DB" modified="2018-07-18" version="1">MPNVMAFEQALVDSSPPASAFAAAAKGGDAAAAPTRSSARLEEKDRTPPLTAVAVRAAKAANGVDAEVNGNGHGADAAGANGRKRDGSPASSLSSLTASESGGDAHATPHDEAAFAAAVKAVQSASVEPIDPIPPLLPADTPCPPASDLLKDIVEVFIDNLKPIKELSEYHGKKTWFHFLINFVTYRFNADPVRRGGFRWETNLLRTRGLKPGQEKEAKWWMLRWEDKIHLLRQMVDFQLTSSLAVRDLIKEQYDIGNQRNARRDPELNGLVLIPAGQTSSQVTLYHLDASPRLYACGNLYKDDSPWIAVSSTYKGYKAFLKTLAEPTKAERKALGLVESSTAPNGPAGGAAAAAGGAKGPFAKAAAAVKGKGKAKVEAGEDYKKDERMARARLEADFREMATYEKHMAAYEGRQMRAAERAARTYERTINVAPTTTRSSRLRARLNYDEDRLDSASVVSGSGAGADEYDDGGSRRKRRRVDDGAGSVNGDGTSAAPSEAGSDVGGSTRAGSRRTSGRQAPLPSIPGERRSSRLQQPIYEPEPELEPEAQAEADPASGDAVAVDAQADEKPEPKEEEPAGEAGSAAAPIPVPPEGLTIPGTPKEPVLFKEATGDDEKKQQEVVQVKPMEDVQPTPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAP0</accession>
    <name>A0A2S5BAP0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAP0"/>
    <dbReference type="STRING" id="741276.A0A2S5BAP0"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="363"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="562" mass="61706" checksum="58AA7AB7043550CF" modified="2018-07-18" version="1">MDELHDRVDEFDGLPPGRILPLPPGVYTLLPLAEQCDNLVLPVEQEWTGQACKRRWDDHVAQQQKPSTPAAAGTADDSALADDDDDEQDEVRDPTDGSEFLTPLFLALPTPPPAQPQTAPQHRRSSASSQRPAFTAMTPMTPSLRPSSPTPSGPSPYAAPAPTDDEQHKTLSSQPIGFLRPSIVRALIEDNRRLVSMNCKPVWAFQPPIAFPPPPPKTPERRRSSIARSRSASIKMTRTQSFYEDDAATGSSGVRLEDVLQGLKAMAVSGGSSTTTTTASGPWAVGFEDWINAEGPEARREHIDRIVRGWKAKGLFPECLGGWRDEEYLIYAPAPSRGVRATFRGPREGETNPLPGSNEAFRMERSACSLFGIATFGVHCTGYVEETDDKPLRIWVPRRSPNKQTWPSMLDNTVAGGITAGDLPRMSIIRECAEEASLDPTFVAKRVRQTNVITYNYRTSDGWLSPEVQYCFDLPLPDPDSAAADAHVIPTTNPADGEVESFSLMPVEEVVQRMIDGEFKPNCALVLLDFFIRHGYLTAESDTRFLDIVSHLHSPMSLPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAP9</accession>
    <name>A0A2S5BAP9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_3342</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAP9"/>
    <dbReference type="STRING" id="741276.A0A2S5BAP9"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="242"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="620"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="518"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="905"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="986" mass="102718" checksum="908D201C7918A0F4" modified="2018-07-18" version="1">MADELVFNFDAPSSAAPAAATRANRAKGGRWTDRAKERKRSQIEQRRAGKPPGAAAAAANPATTGQGGRRRDDANGDSPNKGKARAHQNGGHASGPSGGGGGGSGRGRLEQAVGPAGKKQYISSLFTAEGLPVPSTSSGAGSSGPVIPARPSNAPLTSTPAVAADAQDDDNADEAKEDEGPDPAPELTKLGLSREIVSALAGKLGISGPTACQAGAIPRLLVPAASSHPAKGKGKGKHRPETTAADFAHDAILRAQTGSGKTLTFLLPMLEDLLHLPPSVLASAAAPKPGPSSSVATGAVDRGIGTLALILAPTRELATQIHTVLSSLLSALPYSSRFTVSPRTLTAGLLVGGANRTHEKRRLRKGCPIVVATPGRLLDHLKTTEAFRMAGEPIRAAGPSGRPGGSAGKGANAAPLGQRGPPMGRNGGASSSTTANQLGLRWLIVDECDRLMDLGFEEQMRGILEEVERRSASSPSTMTFAGPSSAAAAAQRQRRRTILCSATASEGVDRLAGMAIGATDEDGNATGESMPVVGARDDIKVKEPVRKDLTAPVSTKRSAEDDDDADEAEEGAADVEEGETAPEPSSTALAVPSGFTPPSQLLHNYIIVPPKLRFVALVALLRKILVKQQKSAGKVLVFMSCTDAVDFWWKALGKIKMGSRDAQPGDDDDEEEEAEKDADRLVSLHPLLSGIPIYRLHGSLPLKTRLASLNAFSGSYTIEDGKKAGQETDAGVLLCTSVAARGLDVKNVGCVVQVDAPTEGGVTEYVHRVGRTARAGAQGTAYSFVLPNESEYPSYLESGINAKEDPSAGGKKQVKLREVGVEQVLREGYGGEGREYETRATDVQMGFERWVNGSEESASLARKAFQAHIRAYATHPSAEKHLFNLKALHLGHLAKSFGMREAPGHHLAGPPAKKKARTAGGGAAPSYDANDQHGGGGFEVGRRRKTLDAEARMRKLMRGPQANGGGEFQIAGTSELEGMVKKGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAS4</accession>
    <name>A0A2S5BAS4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAS4"/>
    <dbReference type="STRING" id="741276.A0A2S5BAS4"/>
    <dbReference type="OrthoDB" id="2529739at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="392" mass="42945" checksum="97855586DBF70C6D" modified="2018-07-18" version="1">MSCPEPQRARFVEQLHDLLERPADAANFRWTADGVSFEISEQQSLALYALSPKWSFRSLASFIHQLSYYGFVRLSDRRKTQHRRGASGDNIVFFHPSGFFSRGDDSRLEMIQRKPRDRSKSAKSQNSPADPRSESRATLQLPQTYPSFADFSPSESSLSGYATPVMQPACSPQRPTFGRASTWCGSSGQLPYNQPAYSATPPAPTYSQEDALLWTTWAGDLHLPGAPPFLDSHLSPSPERAHRTAAAAGPHWSAWARTCGTSEPALAHVVAPPASEAVPNGLTMRGFDEYQPMLTPPLLVDDARRCEYFDVAGGIYPTGSRSGPPSVQGRPADLEYAPHPPISTTSDPRSLQRPHRLRTVPLPSSPLCGLGLNFDGLSNGGGRSRMSPLHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB26</accession>
    <name>A0A2S5BB26_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000030">
        <property type="protein sequence ID" value="POY73963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB26"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="654"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="93557" checksum="2202ADD4BA59040B" modified="2018-07-18" version="1">MLSLRQRVVRLPRSAPPAAVGWLTLSRRSASTAPSPPPETGVQVADPLLLYFSLVAQGKIKKDEEQLRALVQIRKLHADLLDYQPPVQLVTLLDSIRALPSKHNSQAVVKSGLPAWPFRRSALSTLGEGLSDAEEQERQHLLALSDKEKTTQLVKALKAHEGLEDLDTPRGFLLTGPPGTGKSLLMDLFFQSLPVASKTRHHYHAFLLWIYQGVHRALEKQRLENEAEEKAMNELYQSNGKKGYPWSRREEMKARAISQGCRSLQASPTPEQLCDRSRRNLTSRHYTGGRSAHDPALNTREFVLAQVALDLIKTQGWLLAFDEIQLVDIAGAGLVSRVMSWYWRLGGVVVGTSNRVPEDLYKQGIQRATLSPFLTALAHRSPVIDLTSPTDYRLVARSEHGLTTETDAAEPGDFGSVDAWKRWGTRARGWFVKGEQDEAWQEAMRWVVGDVKGEPTTLNVYGRKVKVPWAAGGVARFSFKDLCEQPLGPADYISIGSAFHTIILQDVPILPLSAKNEARRLITLLDALYESKTRLLARAEAPIDSLFFPDAVAAATPPAPDAILDDLPTSFSEGSGSQAPGSSGPVHTLDADTYSSPLNTVFSRGGRNNTRYEAQDTAGEVTDSLVEEMLGDVQQDLEAPYRPNISSYDQSAGVQAYERDQARAVERKEQEEQLVRQLRARREQAARAPVHPSAATPSFQSLAIFTGEEERFAFKRAVSRVHEMSSTEYLVTAHHSPLPSSIRTWEQTLADSLASNSAEAAASTPTTHQMGDKTPLSSSDLLSGVLDPADLRAKWPEGMPAGEREVDVRPPSQKPVLKEEHVWGVRDDWGKKAGRWGQGAKAFEGTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB53</accession>
    <name>A0A2S5BB53_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000031">
        <property type="protein sequence ID" value="POY73961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB53"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="134"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="343" mass="36067" checksum="F5CC58D960752E32" modified="2018-07-18" version="1">MLQAIALRSAVNRTAIPCPPTGSLVRSFGSSSSPPRRTATAAATARRPPPVAGLFSQPASWAASSAQRRAAAQSWTPAAAGPTGPRSFFWSSSSSSRADSSSSSTSSSSSHEHEQSKDNSNAEPDDPQKIPLTQKVKYLFRKYGWTTLVVYLGLSAVDFGLCFLVIYSVGADRVRHAEDWVLEKLHWRRRSEDRLDAGSAGSPREIRDGNYLQRTVEGLSHRAEARHAKHLKGAEAHPSPAAAEAIARGESTAEVARIERESAQGGGKSKYGTIATTAVLAYAIHKTLFLPVRVGITVAITPKVVRMLQGWGWKVGMAAGAPPTAAAAAAAAAAGSSSTGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBN7</accession>
    <name>A0A2S5BBN7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBN7"/>
    <dbReference type="STRING" id="741276.A0A2S5BBN7"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="330"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="602" mass="68252" checksum="97B822C6503536A1" modified="2018-07-18" version="1">MTIVLPNFEIATKEIGKPEVGVNGYDGRHLGETTLLKKGSTREGWDGERTRALDSDILLEHDIELTMRDGAKLYCDVYRPADSDEKVPALLMWSPYGKRYSSINMLPVTTWRCGLKSGDLSGWEKFEGLDPATWCPRGYAIVSIDSRGSGHSDGENQIMGAKMGEDGYDSIEQLAKMDWCNGNVGMGGNSFLAISQWHIAAQQPPSLKAIAPWEACGDLWREQFARGGVFEISNMDLINKLIIKGQKGTEDFCEMYKRHPLAHPYWDDKRPDLTKINIPAYISGSDFSSIHTMGSIRGWWECQGPKWMRWSGVQEWHDLYAIPESTRELLDFFDYYLKDKKNDFVEKTPKCRWTLLQGGDREPIQNIEIPEFPLPNTDYRDLYLSTDGKLSNETPKEAASVSYVSRGDDKSVANFDIKFEEKTQLVGIPKAIVYMSTPDYNDMNVYIALKKLDKDGNVLMHMTIPRERAWAPSHAEIAEKDRTSLLLVSGSLGVLRASHREIDSSKNIHPNWPWHPHTSEQKLERDEIVKLEIGIWAMGWQYDAGESLRVEISGGHAMNHEIRHFSDPTKLPGDETLNHGRHVVHFGGEYPSKVILPFVKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBR8</accession>
    <name>A0A2S5BBR8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBR8"/>
    <dbReference type="STRING" id="741276.A0A2S5BBR8"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="9"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="290" mass="32213" checksum="756D7EB33ABCF836" modified="2018-07-18" version="1">MAKHPTPVILCSHGSTMMLGEDSTAGRYWEEVGKEAMKRGIKGVVFMGAHWEVGGAGVEIASNPGKDAVVKQPVAWVTPDKYVDYEINASPELAERVQHLLEDAGIEAKLKPDLEWIHDTFLVMNWMFPKSSPPVTVISTNAYYDPHLHVAIGAAVRPLRFEDVLIIGTGGAVHNLYRNAWTNIILYRDNFAQTKPPQQWALDFRNEALDAFTKNSGPALRRAAMRLMRHPLFRDAHGTDDHYAPCLFAAGAAGDEDDVGTKNTSPAEVWELEQMCNTQFQFGEWAPIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBV3</accession>
    <name>A0A2S5BBV3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBV3"/>
    <dbReference type="STRING" id="741276.A0A2S5BBV3"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="900"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="843"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="928"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1244" mass="131649" checksum="A6EDCB37CB2C0595" modified="2018-07-18" version="1">MSNGPSTPSSTGRSSNALGRFLNKLRTPTATDSPSNQHDEQPSRPPSRASSPFGSLIGRRSTSRASVRTFDSQASAMPAPPPFPASLNNSSLSLASSSRYPSLDTHDDADLSFPEFETNPFGLSPSTTSLASSHAGGQQHYGAADSAGDATLQARPPPIVARPGTSMSTRSRAESAVDEAVSSRGYSTSSGAAQKESLGLSSRSFGKSLLGKRKEATDMSDAAAISGEAKSAPRAPLARSTSDEPARPLATTTPAFPREPLSSTSTASNDPRRMFGTARPAGTTGMRRARRVVQTAQPVPSAAASAFSDADGLSTPESQGVLADGERSTSASAGAGSASDNSPLEVQQPLAASRSTRNPSPASTTQAPAPAPAPRARPPISPNAHGRSRSELPPSSPRMSLPNDRNANTVTISSSSTSNGLSTSQSYQTSPSEFGAPVAPLFSSRGAQQAGASGTSQQPLGSTAFRNRFLNSSSASSLSSANNSPDMGGNLSSSTSATSNPTPPNASSTLGQGGNVGAGGFKLAPLGAAGSGLSRKPSISMLSAVAEDRSMAPPASRHAPIDTRHHAPARVDRAAKPAVDLGRASLDERRAYSPPRESDGMVPYAHRRTASRTVGPGDSSVLSESTTTGSGTHGGTTLVNTAHGGGLKRSNSETVTQGLMGPPAASATTITRPPSSMSLYRDEQPQQAAPLRPTVARVPSGRQALAERPMAAEVHAEPQDGYRHMQPDPQPQQQQQPAFQPYQDENAYSSRAPYGRPDGPLPPPPAPSTSLPPHQQQGARPVLAEVNRAYPQPQAPSTQQRSTAPLYGVQTAQKAGGEYQVPLRDRSPGLADATPSVTVQQAHYQSQQAYQQRHQQQQYQQPHAQHLPPQQGVSFAPEQQATEKKIAKPIIARAVNGRPYTRCGLLGRGGSSKVYRVISERNDILALKKVDTRNDSESRSSFINEITLLRKLAGKPEIIQLVDSEIQGRHVIMVMEAGETDLHTLLGNYSGKPISLNFIRYIWEQASLLQVIHDEAVVHSDLKPANFVLVKGRVKLIDFGISKAIAGDTTNIGREQQIGSANYMPPEALNDTGLGLGGKRLMKLGRAADVWSLGCILYQMVYGRGPFGHLRDIAIKIAAISSPSTRISFPEVAYPLGKHGESIEEYKFFVGPDLLATLKSCLIFDPKKRASIPELLDQPFLRRTSGDSARPDLPYISRDIMDAIVQRVSDKIRGPRNPLSELDLMDIAQELMGEVWNVQDTLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC51</accession>
    <name>A0A2S5BC51_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC51"/>
    <dbReference type="STRING" id="741276.A0A2S5BC51"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52666" checksum="CC1B7F194EAAFBE7" modified="2018-07-18" version="1">MLQATKRRRSSGTTTGVRDSEATFVLLPESFESSNGRTTVHDKLRRRTVLDGVAAGRVVLLDSAEGGSLRSIDSGSTPRHRGDEDIVSYGKDDSRGSVARTMTAIFYPSLDPAFIIAAEPVSLDKLAIKPDSVEVSAKRARTAKDDLLEQAVVLLNAHTAEMRVSGNANSRRTGPGRNATALLLRAATAVLAFELPCVGSLSDCTCVGHQLRTRADLVLAALDHPAIDREGLAASLAHIEQLNLLWLCLNDIIVGLALGALVRDHDKVIASGVEHLVRTYVLGYLRDLLQWLSSWPMGIKLNDEIAGLICRAFTGLSNLWEQACLGPVLAHLPIRLIGWTGAFGASTMFALTADLLAFLTLPYFVCYVAATVTFRQSFSFLRALFDVFRGRKYNPLRHRTEPATYEVDALLLGTILFVMLSSIVPTVAAFYLAFASSLLSAAIAILNSFPLFMLLVRFKSPYRLPGRVIWTNPSGSASRSDGHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCD9</accession>
    <name>A0A2S5BCD9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCD9"/>
    <dbReference type="STRING" id="741276.A0A2S5BCD9"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="SAP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="442" mass="48855" checksum="8969C7D4C7C70564" modified="2018-07-18" version="1">MPLSVSELRAALAALSLDSRGNKDTLKKRWLRANKLPRETAGSSDGPGQEEAQARRGGQPNPAPRSRPPDQEYDSFLVFDVEATCERIEEPWGKLAFAYPNEIIEWPVVLLQWQRRTPSDGQQSDTSAEAWDLVQVDEYHSYVKPTWATRISAFCTELTGITQDDLESAPTFPTLCSKFQRDFLQRHGLFTPENRTIWVTDGPWDLRDFVSKTCYLSNTPRPDWLAGEIIDLRLLTCTFFALLKKEKKEHARASRSPSPLLNREQESPPTAAGVAGELTAAVSAEAELQASLPSPVPSAEDAGLPVALGSAATPTPSTAEKGAPTTASSPTDYLPSHLLTAPAVLNLPSVLLALSLPAFEGRLHSGLSDARNASRILIDLARRGMVLEANRRVPEGGKGRERRWGWMEPGRGSQVILANVQRRWEEHIKKEKVREAQIAMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCJ8</accession>
    <name>A0A2S5BCJ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCJ8"/>
    <dbReference type="OrthoDB" id="2446291at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="257" mass="27153" checksum="D003F51E8BF7F368" modified="2018-07-18" version="1">MQYGGLPASSYGAATLKRRERSPSPQSNKRRVPPTCSPALYAEAAPDLSRGWSFDATETTAGTSSQRSSPGLDWLRRTQDLHLETPPLNGSHPLAGELDQTALAAGGADSNGDVGMDNEQSMHVETAAQSAATAQPPGVLYQPTPVAPHHAPPLHRHLAGSPQQDRQTSRPPTPASGVQSGMAPPSQLGNASFGLAGPVDWGQQPRTLIRGEDADMMDDAPTSPKRSGGWKVTMGYRADCIKCLQRVPGHYSHVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCS0</accession>
    <name>A0A2S5BCS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCS0"/>
    <dbReference type="OrthoDB" id="2536971at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1597"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1700"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1626"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1701"/>
            <end position="1712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1851" mass="198079" checksum="6F08EBCAB6F83656" modified="2018-07-18" version="1">MLDDPFSLPPPSARSYAGQRSSLGTSTTASSRLAVPDLTRHEAPYSLLLSGNASKYKSSAMTAPAMVAFPSAFPAGKENGLLPSPRFGSSTTNASSSSSAGPSSSPAREDTDLLRKSFKPSLKRRVTFSPTPLASLQSSPSHANRTRPDHHLSGALLFSKDHGPAAKRPRTRENVYSDNPLLEAARGAGGIGGGDDRGLFARPPLAASSDPVSGSDVRGGGSSSPPAPSSTSPKRPALPRSPPRSRRTVPANYGDETMNAWILAGLGPRPFPSAIAQEQSAPTDEVAGTAAEGDDMTDSEEESEQVESLLLPSPEKRAFAFASPPSASASVGPLTASTLSGAGTASAEPIASSSSSPLKSPSLALVKTPRPSTSLLVPAELPLRSILKQRLSAPNCLVKDEREGLRKNGRGRRHVVGWDTENKTKLARERKRDEQVATKQATEEAREAEASAGSGKGKGKAKESEGGAASKASASRETRASSRGAKGSASRPFTSTSRGADQDDDDEPPRRRRNGDDARTGPVASSSASANGGNGPNGRRRPKEPKGQAALDDPTWFRSPLLVLRASLRDGRDGAAMRPAREGTTLSILPRPRAASAPSNAVAIADDQPMLFLGNVTTLSDVEDAYVSLKNAAYCMPDELVDAERTLQPLRAHAEDLISSLIRDIGNVRTFPTWVAEQPVLRQNIGIVDDRMQVDEQGGEVVNVDGPSSSPTRKQPASHTTTSPTKLSLTETQMSRMRDELSAALAAIKCASIMFGNERTLALFDPADVARVMEEIASIASAPGLSVSVRREISPFLPFFFASVSKSAATILAPLLASSVLPALSETLSLEPRIDRYRTALSESLDGLVVLLRDHGRAMLGQDVWQLWLSAATMGLWDGSKKMVSTCDRALKVLGRVAKLLTEPVPSADPWRTDRRAVHKGISTALKDLFTSSPPDAPLDKVDKGGQLRMTYIRLLMVQLAKEGETTQCGEEEAEHRTLSSLSGLTVVPVLLGRHFRKIGHNGIGPWLRPFNSISTSASDTILAISALAWPHLAYAFLSVEPIGPVKMPWLFNKPTTLAHYLKIFESRSERWARAPASKADATKQEQVRLHAEALALAFVAVVYGATVCAHRDTAFGPSRTEDVDLLDRIFDAAILKHLPTMARSPVSRAVNALGWAILSSICRSEPADIESAGLDALVNTALLDGNMATLLPASGALDALLTRAMQQAIRPEAIPGWGEAWLSRHDGRVLSLFRDCLPPAGVDSPELQVDVVRAWMNLLDTVSQHPTAVSEIVAEIAKLSTGRPDVGRVLWTALFDKHDAILEESAETALRGDARAWALAARCWLDMPHPNADWADPLARITKSRLAQNLSEDDFDDTLELAVALLQNRIQDVGLDELGEGQNGLAHAIGHAAWHKDVTTNRLIRALTSRSDAAETSLHLCIELVAGMRSLVRDAQLRGVRACEPALDQALIDGQVARRCLGAINKLLQSASDVAYPALYEALLSRLSRVMAVTTADLDFYADTLAGPLRRSLEQLSRAVDEGESQLAESMLARVPSYTSPLQSFQKFWAETFGASPETYEIPASLVELFKILGSISDGFSVPGCEETLPVANESLPAPGQDGVAHTRSTSERAISARGYDADTSRQPLTRLTDATTNRSSKLATRSTARTHVVSPSLRVPTESVTHARVSVDKALEPVISETPEDVLTEEAQRSYATISRQLRSRSASRSIESVDRTPPRKRARTTTASSDGRSSADDSGAEVVSTGRRRVGKRRRDEAKLARGASGTAAVDRADTPAVAAQAETRSVELTSSTPIDRDEELVRGFLNLPFDTVVQVGRRIGGSPPLRRLIDLGDKAREYLERLGSGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCV6</accession>
    <name>A0A2S5BCV6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCV6"/>
    <dbReference type="STRING" id="741276.A0A2S5BCV6"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="716"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="716"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1104" mass="118738" checksum="B23BDCBAE9CA84A0" modified="2018-07-18" version="1">MPRQGRQPAQLSQQPKRAKSSTTKKSTRKRTSTTVATPAASKATAGKKGRGKAPRSAQDDDEADSDAELDVYNYAARMKRPRGDVDPLARAPAARSHKNGKQKAQNQDGGAGGSDDDEELDSEVDDDSEGGEGAGGFQVRGNEVVEFTGRKPAGFRLGLDSGDEGPFVDSDDDEEIDSDFVDDESDEEDLPRLKGKGASTSGSSKGGKGKARGVEVDLDEDEIDYDDEEGEGWMDLADVLDAGGYGPADDDDESGSDESAPEEEDEDMSSAASDAEDLDALNRLDSFVEGLDSKKRKSRGDGDSGDETATKKKRAVLKERTEAYPEGEFTAVKPLDGSTDGKVDLDDLLSSFTDSKNPRLASLRKSLKPLAPVSESGSGGSSSKTKVTTTNSHLKAAGPMAAPLPGRLQDKVDREAAYEQTKAETDKWNEMVRRMKGESGIGAEGARHERLVLPLINGAGDVHREANAAELSAKFQPTNELEASIQSLLSTAQMSQADLQKQEQAALATLDPADLAARQAELRRQRDLMYRAERKAKRVAKIKSKAYRRIHRKAKEREAAGGPQMTLEDLAELDAIDGGNRAEEERARLEIQRAKERATLKHSGKGGRWAKKIDGLEGLEEERNASIRDMVARREELRKKIAGIEDGDEVDEFASDSDEGGAFDSDDEGQDVDAIRRRAFDELAALDAKEAAAKANDPKLKGVLNMKFMRDAMARADKQVASEAEELRARLAQMDEMGQVADDDEEESSAPGAMSEQVQGNLGRMVFGPSGASAKASTGDSAPQADVPTLSNASTTTKMSAPVLISTNGGPRSRQRPSLSKPLESAADESNPWLTLAEDESAAGKLSRKANKGDVSSAAAKTAAKADRVRGKQAESRAAERDDATVEIDVDAAAGLASERRKKAKGRKGEDAPLVGKALAAVPDGAMEDGASGDSEADLDEEEIDAQRGKGPAAFRQRELVKEAFANDDVVADFADEKRKEIERDAPREEDITLPGWGAWAGKGAKKAKNARKFTKKIDGVDAAQRKDAKLNHVIISERKDKKAAKYMLKDLPFPYTSAAQHEHKLRTPMGPEWSTSTILRDQTIPAVLVKPGVTIRPVDRKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCZ0</accession>
    <name>A0A2S5BCZ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCZ0"/>
    <dbReference type="STRING" id="741276.A0A2S5BCZ0"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="61059" checksum="9A2CD00726B456E0" modified="2018-07-18" version="1">MALFRSDSRDVDFVPGTVRLFEFDQHDGTLAVPELVLVPTPSAHPDDPLNWTAARKHLSLACVCLYTLALGLETSALYSIYVPYSEATGISIATLNSAVGVMYLMVGFAPILTNPLSAVISREIDFDSQFQGKRPVYLGSMLLAIGVAVWSPFIKSTPEWYGRCVLLGVAGGPIFGSTEPSVADVYFQHERATPFSVYVVVLYLGALLCPLLGAYIAEGIDYQAVFYFNAIVIAVVFVFCFVFMEETNYHRDTDSIVTEARNEADPTHDDDDLPKPGAIQLQKVPASSHVVQADVRRKSFVQRLALWTRPRGSVLHNFRDGVLQPLQFLRLPIVWFCAIQYAFGQVYFNMINAITAQILYAPPYLFTTTQIGLTYLAPIVMTIPSVLLFGWYSDRFAVKMARRNGGISEPEHKLWLMLPLFVALPLSILFLGFAPYYGLLWAAYVIGGMGLSCAAGGVVTTAALNYLFDSYHDFKSDKATSASDDSPQMLAVLPPAMAIPFGFGYAITPWISNLKTFAISAACVAFAINALALPMIRWGKSLRRRDAGVLYGKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD81</accession>
    <name>A0A2S5BD81_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD81"/>
    <dbReference type="STRING" id="741276.A0A2S5BD81"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="4">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="270" mass="28907" checksum="DA17CDFAF66039E1" modified="2018-07-18" version="1">MLATRTCFRLAMTHANSSAPRQRLALVSSHFDAPAPPASSATAPHQQTRSHSPARASAPVKGAAHNDSSSNGNRALRPTRPLAPRADEFRFFLPFQTRWADNDQYSHANNVVYSLYFDSITNYYLINHVPRPSPSSPAPLGLIVSSSTAYASSVAYPSPVIAALAVSSLGKSSVTWRVALFEGEYAELATGGKDASAGELAGFGLESVLGGQGVGRPVRVKRDFQTGEQARAAAYGEMVHVFVDPESRRPLPEGMGDDLRQALDKLRAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDH5</accession>
    <name>A0A2S5BDH5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_2076</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDH5"/>
    <dbReference type="STRING" id="741276.A0A2S5BDH5"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="13">
        <location>
            <begin position="72"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY74803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="359" mass="39071" checksum="6599FEB8AEEDDC3C" modified="2018-07-18" version="1">MSGLAAAVAALLGILIVLYTLLVHFSPRDPIEHDSEATYCTAADPENPLPLARLFHPDADTASKDRPSVKLSVVVPAYNESKRIEVMLRPAVEFLETRPVDTEADGSYELLIVDDGSTDGTSEKALKIAKQLEGEFGAKRGQIKVCRLIRNRGKGGATKHGVLHSSGERILFVDADGATRFEDLALLEEELAAVISAQSDQRAAHGLVVGSRAHLVSTEAVVKRSALRNLLMRGFHLYLSLLGLSSIRDTQCGFKLQTRSTAQLLYPSLHSPGWIFDCELLLLAERSGVPLREVGVRWKEVPGSKLDVIKDSIRMARDLLVIRANYLVGRWAVPSRVETGIPVGGDGIKVNGAEAKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDQ9</accession>
    <name>A0A2S5BDQ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDQ9"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="237"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="548" mass="58234" checksum="0E8B9320A223D242" modified="2018-07-18" version="1">MATGAGSSTQASTLITSSQGDSSTQSLEGHGTNGDAGALSESPKQLPTASFEQRNEALAANRAPRPPSLYVPLDESKAESSTSAPSSKTSAYDDPNLAQGVSTPSSLSSWPFDHISQGNNSLGVHSPFVGPLSPSEIHPSYADSPSAPLLHASPPTPTDPPHNLYSAIPMSAVSDSDASFASSAARLDGRGSSSLYGSKKPYHIPHPVGMNGALSAEGDGSFLSRLARDFDSPKAWLVLYFMFNLGLTLFNKLVLQGFPFAWTLTAIQMLSGTIGTQIALHRGAFTQAHLTTKENGVMLMFSGLYTINIAVSNLSLGLVSVPFHQVVRAMTPLFTIIISIIMFNKRHSRQTYLSLVPVIAGVAFATYGDYSYTAWGFVLTLTGAILASLKTIITNRVQVGRLKLHPLDLLVRMSPLAFMQCVFFGWYSGELERVRLYGATEMTKRKAFALAVNGAIAFGLNVVSFTANKKTSALTMTVAANVKQVLTIVLAVVIFNFQLNPTNLLGITLTLAGGAWYARVELQEKSARAAAAAKAPLQPAMPSDIKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE47</accession>
    <name>A0A2S5BE47_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE47"/>
    <dbReference type="STRING" id="741276.A0A2S5BE47"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="846" mass="94019" checksum="CC6F1E3B99CBD19F" modified="2018-07-18" version="1">MSLPPYLLLATLLNSPATVQNAFTTLQTWGPERGFDALRALLPYLSLPTIIRLWRGFDQLKDVISSTLSDLIDVQGDWVVSAQCPPALRDSYLVHYFHSTCNANNSGILQDMRELSERQRRLVEASGMIIDAELENSYNDDSGSESEERDEAPEDEKPCTALADFEKRLAKKTDGLLQHVDWSNVVMAGGGVLGIVTGKNQSEAYDKSDIDLLLYGLQPDELVPEVASLIEQIKAGVRIRTYPESFFTSFNAITIVPPLYATSRQKVQIILQHHASIFEALAWFDLDACAMAYTGNAVVALPRAIRSLSFSSDASGGINFVDPWTARKGDPTGNMLAGRAIKYMSRGFSLALSPAAATAIAAHGLDFDTALTVAQRAIRASTPSMPVLGLGGLKRRQDFVTTAIAHKLEAKREARREECYDREAFYRKRFPHDCWDYGRGAYYGRFGGRARHFQRLDEDVLHSTENEQIHEDFWQYNLVDSSLLAAEDRALVGLVTQVGRMAKMFDQETFEEKHISDASAKPFRDLAVPYISTFETRAVLGYGGEQPPQAVPVEDGASNASVLAGARDYEAYTSVTFRLPRSLLPVIHKAEEKMRTLVHEVRTGAYPAAIQAPLLSPMFPPSADQIITMAAAPLQNHPRGPSISAHIKVAPAKQLERFLPDSFPGPARRETNNRLLEQKDAYAVHHLLTPLVGDESSAFDMSRKYVYRVATIAGLWQFRGLDDDIDEALNIVWQAWTIFSHAAATMPEVSSEVQKRLALAEKLKERDIRDEPVTQLHGSATTDPKFFQQPDMITTVATLHNFLTTLAQAASRGRDTRVPVTAGPGQHWSGDRLRWLLQWISNKEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE95</accession>
    <name>A0A2S5BE95_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1718</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE95"/>
    <dbReference type="STRING" id="741276.A0A2S5BE95"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="447" mass="50667" checksum="DE35F1BB0035554F" modified="2018-07-18" version="1">MAAPYGQIDPIHNIARHQFPVLAEPFLVDQNYDFVKELGQGAYGVVCSAKHRVTGDSVAIKKVTKLFQKKILTKRALREIKLLHHFRGHKNITCLYDLDLVDPVNFDSVYLYEECMEADLHAIIRSGQPLSDAHFQSFIYQTLCGLKYIHSAHVLHRDLKPGNLLVNADCELKICDFGLARGFDQDANATNQGQQQGFMTEYVATRWYRAPEIMLSFANYTTAIDIWSVGCVLAELLGGRPIFKGKDYIDQLNIVLHFLGTPSDQTLRRVGSPRAQDYIRSLPYKPGVPFQSLFPNANPLALDLLVRLLAFDPYERISCEDALVHPYLSVWHEPADEPTCPALFDFGFEQEETMEGMRREIVQEVEEFRRLVRPQLRQANVPRRQDSIPFPLPNRDSMLATPTGAPGQRSYEEEYGRVGQDGGPVEEVPGMELERELARSAGAKMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEA8</accession>
    <name>A0A2S5BEA8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1736</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEA8"/>
    <dbReference type="STRING" id="741276.A0A2S5BEA8"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="144"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="663"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="791"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="791"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="831"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="889" mass="95496" checksum="98D20D4C99644146" modified="2018-07-18" version="1">MGSPPIPDRSPTKSASREVAASSVSSRPVGFGDAPPRPHPGIRPAVAPASVPFSPPKRRTGGSIKGKERAASFDPFRVADDDDGQDKDDDEDRGGDQGGMRESGGTAAIANNRADPPFPAQTRPTYRHILGSGNGGAANPLRTIAHIDIDAAYAAMEMARLKIPQDQPMAVQQWNGLIAVNYPARAYGITRHETPAEALKKCPDLMLVHVQTYKNGETEPGYWDGAKPETHKVSLDMYRKESKKILNVFGDFCPIVEKASIDESFLDLTLPVRERLLKAYPALASAPNDDLDAPLPPPSELGITADSIKWDELSNLVPVEGQKREKVRRLDPTGAPMPSSSSPAKASQVPVDGAETDAAADEAADAMPPPAQRASPSESPGPTDPPLTWSDICLSLGAAIVRDTRAAVTERLGYTCSAGIAPNKMLAKLTSAWKKPNAQTILRYSAIPAFLRPMPFQKIRNLGGKLGTAVKETYEANTVGDLLDYSLPELKAKLGDASGMWLWEIVRGLDYTEVDPKTAVKSMLSSKNFRPYINKYGDVMHWLNILATELHLRLTDARDETPGLWPKTITFTHRSPTFVIRSHQAPFPFTSNLTIAYILKAGEKLFRTAIGAGQSTERITNETTIGPYSNLQLSFSGLEKLEGGQRGIEGFFSAAATAGLTSGATRASKAASVPPKEENGGDDGAASKSPAKRGVGSLFPATSAPAKNKAKATSKKRKPESSRDLPALVSLGNNADGTEEMILASSSDEEVQIEQQQQQQPKKKRKKLPFPTSRCEICQKLVGVADDVRRAAEKEGKVDSDKAARALERAQSEHADWHVARELLEQERKAGGWSTTSSTNGKSSSKKRKVAGDMSSSSSSSHKAGKKEGEGRSKANKSKGTLNGFVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BED2</accession>
    <name>A0A2S5BED2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BED2"/>
    <dbReference type="STRING" id="741276.A0A2S5BED2"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="444" mass="48428" checksum="0FE91495732CE3A5" modified="2018-07-18" version="1">MHILELSDYASTSAVTLEALAAVAMHVASEPTRVVFGVGAGISTAAGIPDFRGGATSLYGAESVRHPTRSHSTLDTRLATTRTAARTKDLFHHDVLLRLESRAEHLGMMATLRKAAKRVTRKGKERTISDGAANAARGAPTAFHGLMKRVAENGRLMRVYSQNIDGLEAAAGLVSPPPRFAETEAGGDRKTRSRIEADDSSSDFDRPRRKTPRRRAPTLAPSPQDLPVVALHGSLDHVHCSVCHHREKWKKRHTRAYKRGRRLPCPNCHDRGRTIDPAPLAFLRPAVVLYDDPSFASSPAAHLISSTIEADMRSEPACLVVAGTSLRIPGFRSLVKDLSRVVKRNGGWSILVNRENVGKEWDRFFDFHCTLSMLPELLTLLVLILRRLVPVLGDTEVFANHLTAFLDSLLPAASPTLADLPPDVTLAPPLASQTPVLESSSGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEM1</accession>
    <name>A0A2S5BEM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEM1"/>
    <dbReference type="OrthoDB" id="2529124at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="138" mass="15613" checksum="3D2F65D5DE78BABA" modified="2018-07-18" version="1">MFRNKHTQEMGLPGGLLHVLPWRTAICGVLLAISTFWGWAVSQNLLPGYMKVPALVGGAFCSVSAISCLVAHFFLAKGETHWDKDKHLNATNRDSHRHPLTKWPHALVFWTTIIALLTEGSYIYMVACVLFDDKEQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BES6</accession>
    <name>A0A2S5BES6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BES6"/>
    <dbReference type="STRING" id="741276.A0A2S5BES6"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057600">
        <property type="entry name" value="TORTIFOLIA1/SINE1-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24714">
        <property type="entry name" value="TOR1L1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="398"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1099" mass="119329" checksum="6A765ECC0AB76F85" modified="2018-07-18" version="1">MADQQFTQSLFATLEQTIAPDTQVIKAATVQLNQTYYTDARCVPALFEIATSGANPAIRQLALVELRKRVSAKKHKQWLAQPQEVRAALKARLLEFLLTETNSQARTASARLVSTIARFELDKGVWPELLPWMWSMTSSTTVSHREVSLQTTFMLLDSIAIAPTSAGNKPENHIPALLTLLAKTVADPESLTVRTWSVRALGKLAEYVEPGEQYEISALQGMIPSVVQVLQQALEANDEPAAKSIFEFFDTVSLSECPIITPHITSLIEFLLRSAGNQAYDNDLRIMCLNALLFLVRFKKGKIQQLNLAGSIITALLPIGAEPEPVDIEDDAPSRTAFRVIDSLATSLPPTQVFPPLFEQVRALSASPDPNLRKSAIMAFGVVIEGCSLFIQPHLESMWPLIQNGLQDPEVVVRKAACTALGCLCEVLEEECAKQHAMLLPLISKLMGDAATQRQACVALDCLLEVLGSDIEPYIPSLMEALVQLLDSAPLSLKPTVVGAIGSAAHASKTKFAPYFDAVMQRLVQFLQLTEEGEELDLRGVSQDTVGTLAEAVGGEQFRPYYAPLMQQAIAAIGIENAPNLKECSYIFFAVVSRVYREEFAQYLPVIMPILLAAIAQEEADASEFLGGDAAADFTTGVDGDEDDGDYEDIDEDINSDDEDAFFKASTQIAIEKECAADALTEVFDHTGKHFLPYVEAAVKALLPGLDHTWHDGIRKSSVASLLGFIATLNRVSEAPKWTKGSQGNSLGPDVSQLVQAVVPQVLEMWKSEDERDVANELCNSFSAALMSVGPALIVPNYVQPICEEVSKILQRKAACQLDDDEDEEDEREQNGADQSEYDAALIGAAADLVGSLATTLGADFAPLFSGFLPDMVKYYDPARSTADRSTAIGSLAEIVNGMEGAITPFTERLFPLFVQALADPEPEVQSNAAFATGSLMYHSQTDLSSQYLPVLSALHPLFGLPRDGQAKHENAIDNACGAVSRMIVKNQQAVPLDQVLPVLLQALPLRRDMAETEWVFQALLVLLQQQNPLVLSSLDHVLAVFAKALASTRAADGSDVFYPNEGAELNAENKAKVIEIVKALAASQPEKVQQAGLATFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEY0</accession>
    <name>A0A2S5BEY0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEY0"/>
    <dbReference type="STRING" id="741276.A0A2S5BEY0"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="67" mass="7384" checksum="098760A03A189FA5" modified="2018-07-18" version="1">MPRSRVKVVPKLGTIFALALPLDPPPDTNDPHELSFDLYRDSFAYRPADRVGKKWKAGTSAGGVDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF54</accession>
    <name>A0A2S5BF54_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair protein RAD57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
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    </evidence>
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    <sequence length="635" mass="67519" checksum="C6732A5AB1464E18" modified="2018-07-18" version="1">MHQVELARLGPASLTSKQRSYLVKAQLVYASQVLLSSPSQLARRIKLPIAECHQLINQLARAVLTLDADAARWSSLDSTTLDDAASFTTGDPELDSFFDAHPRGGIRIGAITEVAGQSSSGKTNLALQLACTVQLPLERGGQRGGALFLSSEGTFPSRRLAQLARHYSEEDNGGDLAWTETDFLDNVHVEAAPDAESLLALLAYHVPAAIERIAAAAAHAHAHEPSERAPPLPIRLLILDSIAAPFRSAHETGSTGFAQRAKEFAELGDELKSIAARYRVAVVVVNQVSDVWDARGRDLPPSFLQPVMTTLDDHAGEQGAVSAVPPPHLRTFSTSTFPPPTTLANAPPNSTSANGNAHTNGNGGTSSGNGNGNGNGAFFPPAPHQQYNFPPLLYSRFQSPHVTGAFSSVSHPTLLPLPPAFRGGGGGGGPGAGSASSTQPVAAALGHTWSHIPTTRILCLVRRRESSALLYPGGGGTNSGSARTRRCMTLVWSPFAPRGCVEYEIDELSGVRAVGQVRVRAVPGFESYDDDAQDEDEDEDEGLPDPRSEDRGARPSEDERRRWRQGATRRDPSATRDGQDDERQYWGSTEDLLLVDDELEVVADLETATAGAVAVTAAGGRVELPPPSRDPPTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF73</accession>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
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        </source>
    </evidence>
    <sequence length="1551" mass="162262" checksum="E59E743E8C63DD3A" modified="2018-07-18" version="1">MAGQYRPRRPHHSRYLKQHELSNAYSALAAELTKTEIRSIGGYSLGRIIGEGTFGKVRLGVHRLTGTRVAIKQVPKSLPSYSPSDPSSPLSLLTREIHHHRRLRHPHVLSLFELVATESSIYLVTELCAGGELFDYLVEQTRLSLAETRRIFGQLVLGVAYLHGEGVVHRDLKLENVLLDENVNVKIADMGFGREFEKGRFMETRVGTLGYMAPEVVAGQRYLGEEVDIWSLGVILYALLTGSLPFDDDDEGIMRQLILDCKYEVPEWLEEDAASLVRSILVRDPLQRLSIKDILSHPFFTRPVASGSAAPSAPTSPSLPNYPSSIHSPGLGLSDAQTPDLALRTSGSGFFGPTPFAASPPAAHSLSEVQRGKQRASDPPLSHVTPPPPPLSLPLSARGARPSALPPHLTTSPTPRIRRHPSTASIDFGPSAPAPSGQLFPPAMQRTSSAGAASINSLRIGMGATAGPGGGGAAAAAVGQKRRRSIGSLKSVRMQDVTEGEETVTLTSGDSAAHEVEVEGSRFASPRFAAASSAGSIDDEREESADLEGDEPPIDYVSLLLTTSAAPALLSTPDEQALLQQLTLLGFDAGQVAHSVRTSACDSCSAIWWMLRRKRELAEAEREVENGFAAGYETGGGEVGGEGKLSRTNSLRSVRRTADRVRDPAAVLYDSPDDAVSPPSRISMPLQRDDYLEILTEEQGPLSPLPTAQAPLSPDTYLEIPPTAGRARERTASTPEPPDREPSPPHTPPKRPSLAPATPAATLTSPTTVAAPATPSAKSPSHSDDAEARLSFFLNSSDMPATASSVGMLSYFPTVESAPGSSPTSKRTMGLSQSISRDSLAFDAVGTPPGDDSTPDAARRERARSGSASLLARATSAIGHSLATLAQGGAPDDAETGESTPRQVPVKLPTTPKRATTAAPGGLNRANDQPVPSQFLRPPAVHASASAPPPTPNYSPSVSASPLPRATHVGVTALPVSPGRVPNRAALTLQSGSAGGTDKASSDLARSASSATSKKNKGGNLLTTFKHWFGQDPHKRKRASMSPRLGGPNSDLSSIGGVSVARSQSMYAGSSAARSAPLAIVGRPQMSSRKSSYNSAYTGAPASAGSATMSRRSSVSSAHRAAYLAENGTPLRAVRSRHRRLSDASRTSRTSLSERGDHSRPSSVRSLGGPGGSATRRHRHSTSATNSPSGSYVNTKEVYRRPPTTTTVRRRHGSRGRHSSDLTGTAARHHRRTASSTSSMHRSSSGSNIAGAGSDGEGYVDEDDVGEDPIMEEDEDEGDRAATVEASDSARDFARSRTLRTLTGGDNSPAASSVGKTLSVGLTLPRTSGSSPALSSTSASLRSSNTSQHHHHIASTFMAHKSTHLFGSPLQPHAPPASALAASQPSSLSRRATVPAHIPRRNVFAAKETNGEWIDEDDELAGYGGGLGQGNTASAGSDTPIDPAALAAPVSGPQYSPGLPGYADSPVASKIWGSVVTPVAASGFAPSSAASSSAARFENRYAGVTGAAASSPGLGADASVFSSASGVGSAGSQAPPRWTQAAPVIEEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFA5</accession>
    <name>A0A2S5BFA5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFA5"/>
    <dbReference type="STRING" id="741276.A0A2S5BFA5"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="242"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="276"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="335" mass="35076" checksum="1ABE8FC8F13F4F2E" modified="2018-07-18" version="1">MSTASTSTPRVLVYGSVNCDEFFVVDHVNSRAQLRQRECSIVRPGETISSSSYSRRAGGKGANQAVSASKAGASVDFAGAIGADGGWLAKELEGYGVGTKQLLVDDKVATGRAIIQLSAKDADNSIVLFPGSNFSGNQGRTFDWGSYSHLLVQNEIPWAETVAALAQARTAGLATFFNPSPMPTQDQLRAFDWTHLDYLLINEGEGQDLLVAYGAEPAPGQPEETLLRLRTVLASSTTIVMTLGANGVMAGLENGDVISAPAGRVQGKVVDTTGAGDCFTGYLATLLVTPATTGEELRPLLATACQAAAMCVEKAGAMESVPLRAAVLERMQATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFB9</accession>
    <name>A0A2S5BFB9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate carboxylase</fullName>
            <ecNumber evidence="4 13">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BMF94_1366</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="4 13"/>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFB9"/>
    <dbReference type="STRING" id="741276.A0A2S5BFB9"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 13 23" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="21">
        <location>
            <begin position="36"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="20">
        <location>
            <begin position="152"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="22">
        <location>
            <begin position="569"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="19">
        <location>
            <begin position="1105"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="650"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="16">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="778"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="780"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="913"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="17">
        <location>
            <position position="748"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="17">
        <location>
            <position position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="POY75464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1185" mass="129547" checksum="11449312DE0D556A" modified="2018-07-18" version="1">MDPSSLATPQPSRPQSPGAATPSINSLRRLGRPNQPLRKILVANRGEIAIRVFRTAHELGMTTVAIYSHEDRFSAHRNKADEAYMVGKGKTPVAAYLAQDDIIRHGVTMIHPGYGFLSENAEFARKVEEAGIIFVGPQPSVIDGLGNKIAARTLALKINVPVVPGTPGAISSYEEGDAFVKEHGFPVIIKAAMGGGGRGMRVVRDAASFESAFKTAVSEAEAAFGDGTVFVERYLDKPRHIEVQMLGDSHGNVIHLFERDCSVQRRHQKVVELGPSANLTDEVRDQLLAGAVKIAREVGYRNAGTCEFLVDSRGVYFIEINPRIQVEHTVTEEITGIDIIAAQIQIAAGASLPELGLTQDTITKRGYAIQCRITTEDPAHGFQPDTGKIEVYRSAGGNGVRLDASSGFAGAQITPHYDSLLVKCTVRGATFEIARRKMLRALVEFRIRGVKTNIPFLFRVLSHPAFVEGKTWTTFIDDTPELFQLVTSQNRAQKLLSYLGDLAVNGSSIKGQQGEPGLNEEIPIPTVYDNKDESKPIDTSEPCQNGWRNIIKEKGPEGFAKAVREYPGVLIMDTTWRDAHQSLLATRLRTIDMANIAKETSHALQNAYALECWGGATFDVAMRFLYEDPWERLRTLRKLVPNIPFQALVRGANAVGYTSYPDNVIYEFSQKAVENGLDIFRVFDSLNYIENMRLGIDAAKKAGGVVEAAICYTGDVANPKGHGKYTLEYYLNFAQELVDCGIHVLAIKDMAGLLKPEAATMLVGALRKKFPDMPIHVHSHDTAGISVSSMLACAAAGADVVDVAIDSMSGMTSQPSMGAVCSALEQSKLGTGISYANIQALNLYWSNVRQLYQCFEANVRSSDSGVFEHEMPGGQYTNLMFQSQQLGLSGQWKAVVKAYIEANDLCGDIVKVTPSSKVVGDFAQFLVANKLTKQDVLEQADKLDFPSSVVEFFQGHLGQPVGGFPEPLRTKIIRDKQRIDDRPGKNMPPYPFAEVRQQLIEKYGSSITSCDVLSYSLYPKVFEEFKEFTLKYGDLSILPTRYFLAKPPVNEEISVEIDQGKTLLIKMIAVSPVNAVTGMREVLMELNGEARLMQIEDKNAAIDTVRRERASKEPGSVGSPMTAVVVNVMVQEGHEVKAGDPLATLSAMKLESNVTAPVSGRVKRIVVGAGDSINQGDLILELTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFD2</accession>
    <name>A0A2S5BFD2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFD2"/>
    <dbReference type="OrthoDB" id="10689022at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="599" mass="64897" checksum="52D0A90BBA64F60F" modified="2018-07-18" version="1">MVSGLLNMRKRAMTLAESPTSPPSPVASLEPESRRVRALSRFSRLGLSLRRDSLVATDVPPQTPVSPTSSRSPTTTFRPLKQIRRQSRSFSAAFSSMFPPSPPTSPPSPTVSISFSNLNRPRPRFASERKRDGLKRQISYPLLRESFDKLAGRDSWGARDESQRPPTPALALSGSTASSIREGSQALVQAGEFGTIAFPTTTTASSSVSSANDRSLQTDWIRQPCSSNAPFPPSRFSTSTDESTYSQSSMSSCVWVEMPTATSSSSFEPFAPVREEESPVCGYSALGLDIRMEDSADVEYSRPTLPLATTMNEDLLTTPTKSSRVYRRSGSTLAWTSKDSPAQQQAVGADKYTDLALPETPKLYPYSPRLVLTPPPTPYLEPVQISPLTMDLAFTPPSPLPVCHEESGQVDDLDETQDLTSVSLLSLTLAEMSENLAQITRGKPDAEDSAPTSSHLPSLRNVPFPSTLKSSPPSFLDMDCSSDSASSCDTSPSHTTIETDSPTPLPRQTGPPRSQRLLRRISQRLRPARLSVSSSTSAASERPLRSPLSPPTNRTELVNKAAAACEVPTRTPPPRRIIKSSLSSFFSPVSASQDRKGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFF9</accession>
    <name>A0A2S5BFF9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Las1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFF9"/>
    <dbReference type="STRING" id="741276.A0A2S5BFF9"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="63298" checksum="AE6C1992C78D6266" modified="2018-07-18" version="1">MPRVVPKRTAWSTAQEFRLVFDRLFASEGDVVLQQDAIGRIKVWLHRGQCPHAVESTAALMQLILRDAEPSTSHAAGAVSEHELRLSYSMAIIRFVNSLVDPLQTTYFARSIASLAAQIGLPPWFVELRHQATHEHLPSIAVLRDAARQAVDWLYANYWLPALNSAFATSTLAAALPPLPLSTLRPLLLTTYKSLSKQITRDASLAGKLKADVQKAYKDIERWIVENSLGGGMRGGKKEEEARERALEAVAEVLWEEGGLVPVAKKKRPTTRSPGLPTELRSLWTPLIAHFDHLYDGALSETITRKGLDMLCSGVTAPAAATTTTTSESTEQMPGAAAAASVPLDRTYAACVVAWVVELLRDAPLSAEPTATVGDDNPLDSFENDEDQDDSDGKDLTIKGVVRTCLLSKSIHAIPLIEALLASASESAGDTDTESAAALLSDRIEPLLPLLRAQAIAASAPNEEGSGGGALDFVRRIEGGEEAEAVLNEMEVRARQVEERLAIGGGGGRDGGRKGQASASQEDAEMQLDDEEEGRPDRDEASSPIGASGGGVSGAWERKQLWRKRPIGMLPKGGVLALDLAPLPTVMAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFS5</accession>
    <name>A0A2S5BFS5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1241</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFS5"/>
    <dbReference type="STRING" id="741276.A0A2S5BFS5"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="592" mass="63680" checksum="F45990A88B6CBD6D" modified="2018-07-18" version="1">MSQQAPPSVAPSGEDAILQTIDVEPEALASDSSALEHAYEVDLTLAEIERGGYQRIGLQFADEQLHDAVQVYRALRDRLPKEKELYVLADTTYGSCCVDEVAAQHVDADFVVHYGHTCLSPTARLPVLYVLTKRDIDPDHAASSIASTSRASLNEEPPKAIIVLYDVAYAHKSHLVADALRSQMPASIPLVLSHLDKRANLRSHARPSTDEAQDAALPRRSSSTENGKGKAPATEGVAEGELASDAAAPAGEASDAADVDGDTEPLAFDLEPEVPAPPTTIPRSTARYELPDGVDSVDDCALIWIGGESLALNNLLLTHGRCRVWSYDPASKTSRLESARTNKMLMRRYATVEKAKDADVIGILVGTLGVAAYLPLITHLRELIASHHKKSYTVAVGKLNPAKLANFIEVECFVLVACPENSMVDSKEFLRPIVTPFELELALTTKAWTGDYILDFSQLLESSTFGQDAGKLADGADAAGTNDEDDEAPVFSSATGQYRHPKKYVQRGFKDADELASQASALALRDQSSAVARVLGSAAGEYMAGRTYKGLEPRFGMDAPAQLEMGREGGIARGYGYERGPDGVTGRDESQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFV1</accession>
    <name>A0A2S5BFV1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFV1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFV1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44294" checksum="A54A18E092322B50" modified="2018-07-18" version="1">MSLVAVEARKADQHCTETTYIDFTLDLANLHDNNVTVHSLHTDRVLGRRWTLVFVRRASRLDFVIAAHPTPGVAFEASFRLSRRDQYGATHHLSKSAKTAGHSRMWPRFGEEIARLSTSAAHLAETDGDTGRPFKLRIAASLTAGQRVTSSAIRTLDDTTLARRAAGPSLTPTPHDFRLWFPHFSDVGADLWANAAMLSSISPYLKTMLASEYAEGSSRRKRPRSVADVVEGGGANNDGGDDSDDEADAHLLSTRPPSLSSEGLGDLTFRQMTIKAARYSTWRAVLLYLTTGYIDFAPLLSSGARSDQLYHDHAKEEPDLPLPVSPKSVYRLAHLLELPDLEQLAFTAFVSSLTRLRAATLDFIVKNWTEVKASEAWKDLKGKAGRGEIEGGSQVIADVLDAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG25</accession>
    <name>A0A2S5BG25_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG25"/>
    <dbReference type="STRING" id="741276.A0A2S5BG25"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF445">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="186"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="244"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="312" mass="32539" checksum="C320E8B80C055E07" modified="2018-07-18" version="1">MAVYACGSNAFGQLADVDDLVFENFIEIRSSSDRVAATSLLDVSWSQTILSGAGDGLAVLGPQPPTQVSRAKCWLGQEAFVAALLEDGHLLRCSDGAKSSERYAHADMNGRGELVLVPEGSLDVALLVATLDQVFEAPMKCIALRLPAPDSAMPAATTSSATMRRDEQITAVASGAAHFILLTSTGRVLSYGDNRYGQAGPFPSSPFPASAAAAVLDHLAFFDGLFPVALACGAFHSVVVTKDGSAYSFGSDKDGQRGGGAAPGSGDEPELLELVLEDAQSTDEVEDREEEIEQVACGAAHTVLLTRSGRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG96</accession>
    <name>A0A2S5BG96_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BG96"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="1096"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="924"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1388" mass="147026" checksum="EE229F8163EF3273" modified="2018-07-18" version="1">MPPPIAPVHPLSPPDPSSTPNAATAAHADLYERRHSATDPLFPQSPPLDARSEDMQRSMSQTTRFEPTNEQPAQARTHNGLPPLSTETDSRSPSMRSRAASPLASPSTRSAYASFPEPFEQTTELPSRLAFPKAPHLLPADQLDAVPLSHLVALLQALSRDLDETQASLRAGTAELAALEKLVRDKGASEGEVERVKVRAKTELAEHRAVEEAERGKKGRGGKDEWSIELPTSAEDAVPAKVEADLDIDNLTEAISSNAFDLGFSPKQLSTDAAPGDDPDDGASVRSRPRSLPDRSGATSRNETEAAEATDEVASISSAPLLSGKSASSNKTGRPRHASLSARFVGYIAAGVTPSSSATQAGITSPKKAAIAEPAAPSPDQKRRPRSGSIRSVNSVASSTTSAEKKGYGEWLGGWRWGKSSGAASSLKETQPAEDEDEDDQTRAEALEEQRQAASGEQEDASTPTGSSIHPDSIRPSAATRPDADETSRGRSRSRTGSASSSSHSSTESGGERSRPSSRRTSQTARSTLDTTLPGSPPSTDALPTEGSGSQDSTDDGPAPLEKRLLSPPESPTSTRKRSPGPPPSFRSSSHQATAAAVLSTPLTASTMSLPTSSPSRLGGYGSSGPASPARSPSTDPIGLSEDPEQTGDLPFVVGRGQANVDAAGEDGDGIEVRHRFVPGVPLYSASEDGPTRSTNGKKAADAATGSKEAINRALGISRTSSHSSHSNASGDALNGFLSLPSKLPPLSLARYSPFSQPSLSMPATHVSLSASTASLTASVSASGSPLVAHTAVLAPASSASGAQTMELDTISAEAAPPSLALLKPSYQSAAAAAGVDALEDEDGPMIDRFGFIYDVHTGMALLKESRRRKAGEASAVDKDTSDPIVSALPEGVPAVMTTPQTELEVHPQLDILREAIGLTPTIEAEKTLSPRASPNELPETGISAAALPNDSRPTRLVRAPSSSHASRQPSPAPTGTGPQSMRTLLVQLRTMTDALEQSQQAAWDAFIRRRQAKLAKLKQAQLKDDDGMTGGATLRERDRERRKSLFLAAADESPSDSISQEVWSSENLVGVAQMGTEKKGKKEDWNEFKELVRKGIPIAYRPKIWGECSSANEAREPGVYQELLAQAETDAEAACLKQIDMDCEFSSDALVSCGGSTDNIWKTGHRTFPTNVFFAGNGPGVAKLRNVLVAYSRRDTKVGYCQGMNNLVATLLLTHPAEEDAFWVLNILPSDYYTSHLLVSRADQEVLKDLVDRTLPKLAAHLEDQGVELSAITFGWFLSLFTDCLPIQTLLRVWDLFFIHGTIFLFRIALAILKLHETDLLDCDSAAGLYAMLGQLPAGLWNADRLLKVACDDLASAVKDKVVASLRNKHVKALEAEMGLHEADADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGC0</accession>
    <name>A0A2S5BGC0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGC0"/>
    <dbReference type="OrthoDB" id="2526823at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="421" mass="46020" checksum="37D5DF062814F7FB" modified="2018-07-18" version="1">MDDELSRARPPDLPLFHVLSPLHQSLRLLRRVVTAFLPFLAPLLPYLLFFFILWLSTVALRSYITSYISSLPSVLHAPLGRVLAAIPAPRILLPSSRQVYSLVALPSTLFGALRGRGSRSPSFELLSASAAQSANERAHHALDVFDNLLRLSSPEGPNSLALEPVAIWELSAAVKYSSALDDRDFLANQLAELGDLSRNVKDHVIELNAQGLNAFSFILNDFTRLETLLTSLAASNKRVSAKERADFERLLEVLFDRISDSLGSLLISLDRAIPTATLASDSAHKIFTSFEREKSAKTNEWEDLPWPSRLLDAAGTGSKKARLLRKDLELTEASAFAVRNVWKGLDKTRDALKSYQHNVGFYKAGIVGSHLAAHGLSLEDEVEGLKGVMAQMRNALNEAKHVGGSGSRSRQPAGLPASSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGI9</accession>
    <name>A0A2S5BGI9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGI9"/>
    <dbReference type="STRING" id="741276.A0A2S5BGI9"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="586"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="646"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="716" mass="75658" checksum="78E770FC039A3B94" modified="2018-07-18" version="1">MLSLDTRMVVDGSAVSMSVPPTSYSPVTPTDLTRAFEYDVGLSPVVAMHESGIKHEARSSSCEEDASLGEFDFGHDLPALSVGDSCSPATSPASSWIDDAHSAATPDPPAFDLVATTGSWDDQLSAGFAAPLDKDRRRWWATETVTDSEKAWASQHMSNMERSTSSIFGAMPEMPHSVIGAGVLSANSVGVGANPSAPTGPLVFDFDRQGALLCADGVEIRADLTANFDHGETGVSAVLPEPTTMLAPVIAAPAMLGADRADRLPGVPLPFDSNFGPLSDLSLDAYMANYGQFGRRDGTSPVLESRRQPVPGFRHPNGAAQQHRAEQQQQQQLFYQQQLFAPAGSFHAPPPPPAFGTPVPTVGVASAPNPGYVPVQFTTATGATYAVAIPIAASNQAAAIETPHGTYYFVPSPPAPSPSLPTPTQAPLGVMQTPPAAEAPLPPYSEAVMALPPLSLQPTESDFDATSPPAANTGANAAKKARPAPRRPRKATAKTAKQRSVSRDLDEPVEAAGVEPAKSDSFQLPQGPSAAQIAAENAAKAAARVAALGPTHKIRLPVGQGKRGSTKRKADSDNSGSNKKDQSRRFNCPHPGCGRGFARNFNMQSHYKSHLGVREYDCPWCTKKFSRRHDRARHCTGVHDAVVDREGNITGPHPVVNKNATNDDVASLGHADDDEDDIDAEGDYDYEHYNTNAFASPEERDSYGRGSIASVSAHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGN3</accession>
    <name>A0A2S5BGN3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGN3"/>
    <dbReference type="STRING" id="741276.A0A2S5BGN3"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="291" mass="32289" checksum="332470D940D99030" modified="2018-07-18" version="1">MTVAPHPADRTTVLDLPSTATRDLLLLVLLADTPIDAVRDEFGTYHDIFASTFQHSIELAAVEKGITQEEDAEYKLTIESYDTKNGDFPKEERVKQADGLLITGSASSAHDDEPWIVTLVDYIQRLPSLNPDLRTIGICFGQQTISRAYGTMPGPNEKGWEIGVHNIELTEHGRKVFAGRTQLNIHQMHRDNVPSVPEGFELLGSTDKCPVHGIVKYRDGVSPADATLEDVRIVALQGHPEFNSKIVNEVIAMRESKGVISKEVADESRENADQHDDGQYIGRVFLRMFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGR2</accession>
    <name>A0A2S5BGR2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGR2"/>
    <dbReference type="OrthoDB" id="2530165at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="53790" checksum="08EBD7593FCFB857" modified="2018-07-18" version="1">MPTSGSSRSRRPRSDRDDASQRAAKRVAAIDRAFDAAGSGDASTIEKSRRSGRRAIVPDDENEDDEDEMMLEAVDIAPTGQQDPGLGGGFLPDESTYDPAGGGEGGGFLPEPGSGAPFSADTTSGGGGFLLPEDTNMDGGFLPEPSDAVTSEGTFQGGGGGFLVDEAGGGEVEHLAGGFLPEGNAEPDYTNDGGFLALPDVPQQFLGAEPSASDLLPLPDPNAPPPRDRIALTAIPAALRSLGLHQIGLQGAEVMALFEEVASDDDEAEGGKSVHRERFKEACQVLLGSDDDDEDDDSDLGDRAEYREAEDGQEDDFIGPGRRRLRRGGAEAATAARGALKDEEPTRVQPTRKSTRGKAAGAGEQPAAAADEAPTLDALPPNFEEDDESSFGSNSDAEEQSVGKGKKGGTKAQTKKGKRGRRVAVDPSQPLSPEDLAAASDTFDLFFEESPQLPFTQKDRHISLLELQRACRVLKEKMTDGDLNEMLDYAARARGSVNLDSFARILLETGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGY4</accession>
    <name>A0A2S5BGY4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGY4"/>
    <dbReference type="STRING" id="741276.A0A2S5BGY4"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="499" mass="55397" checksum="1AB0CCAA87782A3C" modified="2018-07-18" version="1">MSDNMLSKAPSKEQEAIEERDEHLALANGMSPEERSKLERKLLWKLDARFVLLVLLYIINYIDRSNMSSARTKGMEKDLGVSDTQFDVLLSILYVGYITMQIPSNMFVQYSGRPSLFLPACVFIWGGISAATGAVKSFGPAIVVRLLLGVAECSFFPGSILLLASWYTKRELGKRITLLYCGSLISNAFGPLIAAGILGTMEGKGGVRAWQWLFYIEGGLTMAMAIVAVLILPDFPHNSRHFSKAELELAQLRMTEDVGTKDDTKVSTWTAFKFAVTDYKLWHMALALTSMVIGLSFNQFFPQLTKTLGYNNTQSLLLCAPPFAFAAIVAFLVSRDSDKRQERFWHIAVPQMFGIVGFVIAMTTHTFAPRYISLFLMAGSYSGFVVFYAWVTSTFARPAMSRGVAIAGVNAFSQLGNITGAYIFPARWGKSYRNSYAICIACFAFSMALCAAHRWNLARLNRKLAKRDEAEQLSGPEAHGDVQAMDHLAAFPVGFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH13</accession>
    <name>A0A2S5BH13_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcineurin family phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH13"/>
    <dbReference type="STRING" id="741276.A0A2S5BH13"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="126"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="784" mass="85284" checksum="ACE51BB744B02321" modified="2018-07-18" version="1">MNRIVSSPVIRSPSLLPRPQPRRRKTLTQPFPPRLVLLLRALLVLLVLWAEVLSFRVAASWRCGFDDAPSVKGRVWDGSIPDRGGGGGGGGSRDTSRGHAAARGWTTDDRWKVTAEANHPAGTPFHVLVVADPQLLDMRSYPGRNRFLKWIGIKMTDLYARKSWKAVSRLSRGKSGGKVDAVVWLGDLLDSGTEMVDRKEHLKYVHRFHRNFPLPRASTSFFSTLSRNAHAASSHHLIPPIPSILVPGNHDLGLHSASSSLASYARERFNEAFGPTWGEREWNGWSIVWVDAMALLEPEFVDGGIGSEYSEMKQWIEDLGDGPISQPRILLTHIPLYRPEGTSCGRMREASRPIRQGTGRNYQNELDERTTKWLMDRIRPSLVYSGDDHDSCVYATGFTSPLDGRTPVTETTVKAFSMAMGVQYPGYHLLSLYAPLPPSDYPADLASSDTPVSYTYTQTNCTLPDQIGTYLHLYLPLAACFFVFLFVPKLAAAIRAYFQRKKHRRAASARTNGLPSTGAGTNEGGSRGGGKGGRAGHFRTLSQKLANLAGGGTAARRATTAEEDADVDDAESQFPALLGGVSHLDASPYSNTGVSESDSDLDDYDGRGGTSNGGGGGGGGGSILPTSMRNSPIGTPARGMSEKGANGRGGQHVRRVSRVWLWEGSSSRPGSPRDSMSLGSHSVRSGGPFAGASLFGRVSHLLSRLVDRLISNSLLSPMYRRFVRPIWRSTRSTWRKVAAPLASVAGGHVGGPVGQALAEAIRDLSEIAWPAVTLWCVHVLWYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHE6</accession>
    <name>A0A2S5BHE6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHE6"/>
    <dbReference type="STRING" id="741276.A0A2S5BHE6"/>
    <dbReference type="OrthoDB" id="2522796at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015647950" evidence="2">
        <location>
            <begin position="20"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="715" mass="76045" checksum="666AFFF6AAA14A86" modified="2018-07-18" version="1">MRLPLAIVAFCATVGIATASHDSAPHSSVALKEGSSHASAVARLDERGLLDLDIGPLHFGIGDHSQAHKRPSAFWRCDKSGKDGFEVDVLGFGRPFWVPEGWLYFGLGIGWAPAHGWECDASFKLPQLFIGVVHQVTWWAPPSVWLDAHVGVDLGFTIPAFWNIDAHAGVKLPTLGWTCNGSGKDGFSVDIHGNGRPSWCPKEWLFFGGKIGWAPPAGWVCARDFKLPSAFIDVAASVTWWKPAPVWLQAHAGADLGFTVPGFWGLSGGANAGVGLGVGLGGHAGAGAGAGAGIGAGVGVGVGVGGRPSTGWKCNGSGKDGFSVDIHGKGRPASIPSGWLYFGAGIGWAPPAGWVSPVDFKLPSAFIGVTGSVTWWSTYLHVVALSVPHSVTDAQGARTEPSSAWLNAHAGVDLGFKVPGWWGLGLGVGVGGGVGVGSGHGPSWTTVIKPTSTTSVKHSSTSHRAASSSTRRATSSHKVTTTHKATTSHKATTTHKATTTHKATTTRKVTTSHKPAKPAPSAPAKGWIGNGSGKDGKEIDWQGKACPSHYPAGWLWFGSEVGWAPAVGWKGASGWIATQAEIDILIKAKWWLPAVGWQLGAGIECPASWSLNGWIDVRIPSHKWMCDKTGLDGFDFDYRGRARPSDVPLGWKWFGTKHGWQPCAWFQLPSVDFVPPKSWNAGLAVWWRPVGEWQYVFKGGFRLPSWWRGTWRYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHF1</accession>
    <name>A0A2S5BHF1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome control protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHF1"/>
    <dbReference type="STRING" id="741276.A0A2S5BHF1"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1085" mass="118988" checksum="4FD9BF130CDDAA33" modified="2018-07-18" version="1">MYFPSPLPTTRLSVSTAAVPVGPSPALKTTVYKTPGRPAKGKFKDSLGGVQEEEGEEILSIARGPLPGEGGGPYGRRPTLWVALGREELSVWSVRPKVVLAKVRRTPISLRTHGSNAAVQFHGPDRVVVTTSNGTNLLYSILPAPASRTKGATNEVYALPGGDKAEEAWPKGPGEGGELEGIILQAEGVRSMSIGEGIGSQPPPPPRRGSGWDSLPNGLHGETASETIILTDWDWLVGRDRTNVTITHMIPLRQEPHDVVHTPPPFPPTLSRQQSYSSLRTAHTGPAQTRSGPTTFVLTTSDGRAYLVRWAPPIDTASAYEYHETSRLASASAASLWTPRASTDSRRFDQDTASSNWSWTGTCFHPPCEREDGTIDVQAQEAVLDRGKGASTADVNTAMDLVAIGCEDGTVAVYSLPAPATLQQASTSKLPVDGLQRPLVSHECSLRDSLNSTASALVTGRVECLEWTSDGYALACGWAQGWSVWSVYGRLGSWSVAGGLDAGFGVEGERSDSFEDGFMLGVRKLFWGPGNHELFVLCPPPVHPKRKPHDEQLFVVPFAKSAVTAAHTPDNTKNGFLQLDDRVLVYRGADQPDMSVINPESDVWQHIKVKDSPLCDRICGRTDTDRLQIPNAYLTSQYPIRYAVISSDARLIAVAGRRGFTHYNALSGRWKLFDLEREEQAIRIVGGMAWWSTNLIVGCEENGFYSLRVFPRDRPLALDEAVELVTLDSEPLVLSVFEGSLLVYTADNTFHHFLIRQIKGGTPRLRGCGSIGFEGVVADPRKVRGLSWLVPRSQRRFGDPADDLNVATIIFLISGRLVLLRPRRAASEEVKYDLQILASRVEFYWTHLSGIGSLENSLWAWDGHHVRIWLDALTIEKVRVDAKRDAYETVKGSVEIPLDFYPLAVLMEKGIIVGVDQEISLRRNLDFAIFRLVTTVVVNCARKTEVTRWEFLFDVVGKPRDLFEKCIAAGFLKVAASYLLVLHNLEPLSQSSKASTDTVRLLQAAMHAEDWTEQFRLALTSPEQDRHSRVSESLGSPPLMRLPMRKSFDEHGNERFAPPTGRLGGGLGLAGVGDGVEGGRRERMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHX7</accession>
    <name>A0A2S5BHX7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHX7"/>
    <dbReference type="STRING" id="741276.A0A2S5BHX7"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015547222" description="Mannosyltransferase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="618" mass="68687" checksum="570143DAD023FD52" modified="2018-07-18" version="1">MPRRPWLWPLVLAVSFRLFNAVCSRAFFQPDEYWQNLEVAHRWVYGYGYQTWEWRSAVAGAVTTSNPKSDKWGNSVQLVSMLKTGGDGGIRSLLSVIVTAGVYAVLRAAGLDRGSFLILAPRLLQACIAAATDLAVRQLAMRILGTPYASAALFVSLTSFFNFHASTRTFSNSTETALTAWALAVWPWSLHAQAPSRASNRSNRDRLLGALALAALASLIRPSNTVIWFALGAQLFLRASWTGRRMILSVTVSIALAASVLSFVLDTAFYATPTFTPLRFLRTNVFQSISLFYGANAWHFYLSQGVPILLATQLPFFLDARQRSARARTGGGTANRDALRALGTTGAVTLAAYSLLSHKEWRFLQPLLPIMHIFVALSLVDRFLSDGRSARRTTSSAFPSGLCRRLRIRPLHAGLVLFSLVPAFYLTAFHGLAQNTVMTHLRTALERDRLEGRGPGEVAHLMPCHSTGWQAFLHRPEMDEWIDVMQSEAGHRRSPRRRMWMVTCEPPVLGQDPSTYQDEGELFYSDPCGYISKQLAAPTPRSSSSSSLARSVSRVVLFSSLLAEPCRDAESHRAETVGELLRGQLGYTEIEWDGWNTLGGWHEDDRRRGTVMVLRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI85</accession>
    <name>A0A2S5BI85_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI85"/>
    <dbReference type="STRING" id="741276.A0A2S5BI85"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="617"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="964" mass="104941" checksum="6882DF0CF1F93742" modified="2018-07-18" version="1">MPGPAPAYSPVDEHARLPPGAATPLAAPSAAAIRGGGAPATGAQHQIPPPIASGTYPPVHHSSGFQVESRPYGGHSAQQQPAHSETDPLATSTSPYLGAHDFADARNDDDSYRGGELHPGQRQQAHSDPDEAYTAIALGSPQGHGPGPLEYPPAAGAIDSDPAPRTSLSTYNSLTQLRAVEAGGAYLPTARRHGGDNGEYEMQVDSRPVNPTVTIDPSAIQQTGSTNSARAERMYGSSAEKRNGHHSSPSSGNNSPRSQSRDRSRGGGLGQWSGPAGGNSPYGRLGDENAGGASGFNSAASSNPNLQFADGDFIVSGRGNWFSRMVLAIYNSHYVVRWMIYIIPVLIILWIPGIVNFTAKPNGTIWSVPLKYWSIWLTVVWCGWWGAALAARFVPALLTRTLGVIAPELRHYISYVKAIRFWAGTAGWALTNWITFLPLVRSRATSDHSKNTLYLLTQGLFGIFLSFLVLLVEKLIVQVIAHNFHKRSYEDRIVEQKFQIATLVNLYLHSRDIGRSDTLDGAMRPKNRRQMSDPTLLVKKALKGAQKAAQTATTVIGTVASEIAGERVLQPNSPASMVTSALQSANKTKQLARRIYYSYTPRYREGMVLADISRCFRNRDEADKAFAIFDRDGNGDATLEEIEMSCLDIHRERVALSRSMHDIDSAVGRLDSILVSIWWIVAVLIMLGLLNASFQTMITGAGTFILGLSWLIGTTAQEVLASIIFLFIKHPYDVGDRVCIDAVDYTVLEMHLLSTVFKRVDGTVSQAPHSQLNLKFVYNYRRSMFIIETFAFDVDFGTTFEKLEALRARMLEFVQTERRDFRPYVDIAVIDFAKQGAMSLTATINYRGNWQNVSLKTQRRNKWMCALRIALAELEIFGPAGAGNPSPAPADPVKYTQIPYDEVKAAEAAAATKKAEAPPSPLLAEGETPLRQAARLGEHLVSNDGILAEEGGAGQGALRAKQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIT0</accession>
    <name>A0A2S5BIT0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIT0"/>
    <dbReference type="STRING" id="741276.A0A2S5BIT0"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="332" mass="37267" checksum="60D6DF50C6413695" modified="2018-07-18" version="1">MPPRKSTRSAKGKQVEPEPAAAAAPPPPAPEEVEAELTTEQPAATTDMEEQEALQEGSGDAGLDLRERDDAPEAGSSSSSGAAAGVDLSERMNKLKELRKRMGESARANRQDVIAEVNAQRASARTLAKLERKRQQAEAMGEKARAAETGEDLERKKNWEYSIEDNERWDKKLARKERRADYSFTGLTSSTGLSDYDDVTRRKYKKDLDDFKPDLATYNKQREAALQSDALVASATGGEVGPVLDGNGLYRDANSFVYADHKPSEDQVDRMISKLNSDIDKRQKRSRKRDDDDQGDITWINEQNRQFNRKLSRYYDDVTRETRENFERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIU0</accession>
    <name>A0A2S5BIU0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chord-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIU0"/>
    <dbReference type="STRING" id="741276.A0A2S5BIU0"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="161"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="237"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39441" checksum="7F3BC5EFCA73BD27" modified="2018-07-18" version="1">MAATVTCTRKGCGKQFNPAENGDAACSFHPGGPVFHEGLKSYSCCADVNKPVTDFDDFMKIPPCATGSHSAEPAAETNGQAAGVKVDSVAAPTSAASSKETLGTAKAVTSDLQFKSANALPMPKPATTKEASQDQPQKAQSTEYVEVQDDPDATVEKGTRCKRKACGLEYEGGDRSDGECNYHPGVPIFHEGSKGYSCCKRRVLEFDEFLRIEGCRTGRHLFVGPKKSAEEEEKEELVECRVDHYQTPTQVIVSVFGKQANKETSGVKFEAEAMHVDLILPARKRFTKSFPLFGTIDPAASAFKILGTKCEITLVKADARSWPSITTLDPELAKRFQIQLAFSAGGGRGTVGAKDMVLDQTNAAAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJE9</accession>
    <name>A0A2S5BJE9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_0145</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJE9"/>
    <dbReference type="STRING" id="741276.A0A2S5BJE9"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="59"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="408"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY76892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="611" mass="66038" checksum="6639274B3FD6FDF6" modified="2018-07-18" version="1">MLLSAKLRGATRLAQFHTTSRVGITASAASPATTALGSRQQARLKIQAQDAVSPHLIDSFGRRHDYLRISLTEKCNLRCTYCMPEQGVPLLPNDSRLTAAEIERVASVFVRNGVRKIRLTGGEPTVRSDLVDIVERLGRLRQLDSLGITSNGIALKRKLPALVDAGLTHLNLSLDTLDPFKYELMTRRRGFDRVVEVLDLAQRLGGRGSPLRVKLNVVVIRGVNDDEVADFVALTRDQNITVRFIEYMPFEDNRWSTRKLVPSADLLATLESKHPDLVKLRDSANDTTRAYAVPGWRGSFGFISSMTDHFCGTCSRLRIGPDGGVKVCLFGPPVLSLRPLLRGSSSADPSALTSPATDDQLMEAVGRAVYGKKFAHNGLGATASRRPALASKPARSIPVHLLPLRAGPRLRTFSTSRHTSSNRTFSSSPRRRSDDDRLTHLDPLTGKASMVSVSAKDATKRSATATGEIHLGARAFSLIDLPASDQDTAALRTKKGDVLSIAQIAGIMGSKHTALLIPLCHPLSLSHVAVSFRPVPDSHSLRIEATAECVGPTGVEMEALTAVSVAALTVWDMCKAVAGKEMRIGEIKVVRKTGGKSGDWARPPDGEPGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZC7</accession>
    <name>A0A2S5AZC7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 69 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_7097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000170">
        <property type="protein sequence ID" value="POY69899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZC7"/>
    <dbReference type="STRING" id="741276.A0A2S5AZC7"/>
    <dbReference type="OrthoDB" id="3235770at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF2">
        <property type="entry name" value="CAPSULAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY69899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="87976" checksum="36CCF24C95808C93" modified="2018-07-18" version="1">MVSIIVSPQQRFAARIAAAVVGLLVFKWFFFDSRPASAAGEIAHPAIFERITLGSPLSGQSLDTRKYSFLQSRIDRDETHDVFDNDIQAGMDDFWTRFQKPFMTGPETFHLDEQVVRGAIDELLGFNGWAAAACSSLTRPFGASKKEDDWSDLARPGALYYFALVVHGADHFLIDQLAVIVQLAKRLGPQSVFVSLVDYASTDSTPFICDLAEAVMTLLGISFRIRHVPAMTVDPTASYYPLEEAYTRNLALEPLHELWERRKVQFERVIWLKGFTCPNDILETIRVSYVNQASMVCSMDWKEHNGFFIYNDRWRTRDMDGSLFRGSKSTSPIDEAPPHDAASGARYALHLPFQVFCCESGTHIVDPHKSYYWGITYHSAPIESVFNTSAASDRQAPRWSEGPCMDSAQLHFCRDMWMGSFREGIKEEAKRVAADERMGKSRQVHPLMDELIQSMLASFAPITAPKPGGYPNSGDYIADETGAGLTGNDVAGSLKGGRKAAAAAAGKGKGAAPAAAAPPAAAQQAAADEEGEGEEEFDEEDEEDEGPLPGEPVGYESNDELDSDGKGRPIDLALKLVDDDDVQDAAQAGAKGKAAAAAAPKDAAANKPKVAADGPDAAEWDAVKDNNGRPLAGKPDSGPAAWKQADGDLPADAAAKKAERGEQDAAEPAEKAKAVKKRSLFAKSEKDASVSATDKHRREKRRPRSLPNHDFPYAIAKILVNPRCVTTYAGVSHTQLALDLFGSGEDREPTQHEGGKYELDEWRTAPESFVCQEMRTTGGRIAPKQQRRTGFQQARLLQNGWRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZF9</accession>
    <name>A0A2S5AZF9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_7064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZF9"/>
    <dbReference type="STRING" id="741276.A0A2S5AZF9"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY69932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="187" mass="19668" checksum="A88CA24171D8B752" modified="2018-07-18" version="1">MSSTPNLWGTAAAVGLASGLIGYFVGVGATLPITRGLEKGPQANDEESDYETDSEAGDTDALQNVKAEGDEPCKLVLVVRSDLNMTKGKIAAQCGHATLACYKTLIRSNPALIKHWERTGQAKIALKCESEEDLQLLQASAQSLGVCARSIQDAGRTQVDPGTTTVLGIGPAPVRVINQVTGHLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZJ1</accession>
    <name>A0A2S5AZJ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)</fullName>
            <ecNumber evidence="2">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_7048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000161">
        <property type="protein sequence ID" value="POY69956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZJ1"/>
    <dbReference type="STRING" id="741276.A0A2S5AZJ1"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY69956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="212" mass="23372" checksum="8F14BB6360F0DAE3" modified="2018-07-18" version="1">MASNASGNLLADPSEAFARQLNLFTGWKDPALTEKGRGEALEGGKNLKAAGLTDFDVAFTSVLQRANTTLDIILEEIGQKGLPIHKDQALNERDYGELTGLNKDDARKKFGEDQVHIWRRSYDVPPPGGESLELTAKRTLPYYNEKIAPLVAEGKKVLIAAHGNSLRSIIKQLENLSPEEIVNTELETGVPIVYRLDKEGKVLSKDILKHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZT2</accession>
    <name>A0A2S5AZT2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000154">
        <property type="protein sequence ID" value="POY70015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZT2"/>
    <dbReference type="OrthoDB" id="2538180at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="257" mass="26237" checksum="38C12D9582B630D0" modified="2018-07-18" version="1" fragment="single">MSGYDSAGGASSTFGGPSTATAAGASNAGGGTKRRRVNADPDFYPGAAPTTKRAQANWKAAQEQAQIRNAQAMQQQQQDVQMVNAAGGAGLSQQGGRIHMQAETQQPRQPILSLATLPPEALQRYLSRYGLIDPAGLLSFHHAVFPVPPLPETLHPPLEGRQLNVRKAKMTYVPAARNAKILAARAAAGLPAPGTADEPASTGEAPGTNVRGELEANSNAGPGAVDATAADPTATEAPIHVAKPAEETAAASSTGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B025</accession>
    <name>A0A2S5B025_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000143">
        <property type="protein sequence ID" value="POY70133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B025"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="312" mass="34694" checksum="8B3BB9D57932EB0E" modified="2018-07-18" version="1">MSDNARYQPGARGPPVHAPDPERDFVACQALYLHVQASAQRTQDLYMLTLLRKYFAPVTNGEAQFTHCCTTATGCQLIGALVNDLRGAERYYARREAALVVDLAHLLDLTFSVDLARTGPPFATYNRVYAAAHAFLTRLDAHDDIEMLNHLYQHYITMYTSLPAHKQADIYKALREWLTVRVENAVVEAQEQRTIVHVTHALVLAAQEIAGTLLPAALRNMTRSATEWLASWRPEDDPTEIQLQMMCLRWRNQFLLGLLHSPWIAAVTSHRPDDGYGGHGFHGGGPGQYGGYSQPVGPEQHFSGGHGGMGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0A0</accession>
    <name>A0A2S5B0A0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6793</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0A0"/>
    <dbReference type="STRING" id="741276.A0A2S5B0A0"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="254" mass="27006" checksum="663F45880E2BDE11" modified="2018-07-18" version="1">MSAYTAAFERGGGSHPTVAVNVTGPAPACDLYAALTVPPTFIVDPCQLQRLHETGRLGDVAAADEPPSLSVSGDTDLEAPAWKTGPAKVLVRLEASGSTRRTARRDEPWRVHRVPLHLRYQPPTATQPGKAQATETSAQLELPEPVLFWACSAPGTSLVEEAGPACDLATRERFPQFANSTLYCLPSDSGTQQSRDRLMVRAPVGNLAHLALVETVTSISVWLSFAYLAYVAVRTRAGGNVSPGKASGTRFKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0V5</accession>
    <name>A0A2S5B0V5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0V5"/>
    <dbReference type="STRING" id="741276.A0A2S5B0V5"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="344" mass="37079" checksum="EBC3A36DB5282637" modified="2018-07-18" version="1">MSQSTPIRRPSYTPSLSGTPGSPALEQPSPSFSRRVSTASSSTAATQYAHANPSPADRKKRSRLRDYYGLAKGAAPKSGQSLDIDSPAAFDADAYFNSLVSTASLPDLLRRENDLLNEIRELDGERQSLVYNHHHELIDASDTIRKMKSRAESLDQSLESLKSSFESIAQLSGSLATLSTRPPGAPVPSRPARSPLTTPDLDEARSPASGEPQSPKTPRPNRRRSSRSETITSPTAGRTRSASTATLSSHPVAVPSVPFSPLLHTSALLALPIVLDSLVSCAPTDHQHHQQQRAKADSLWGAWEPALRSWEDAGVEGAREIGMECREVLRHAAARRSESVSSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B174</accession>
    <name>A0A2S5B174_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B174"/>
    <dbReference type="STRING" id="741276.A0A2S5B174"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24850" checksum="EDDE5D3EB9237F81" modified="2018-07-18" version="1">MPNNRVKTLKALQSKKTKIASGQVHPNSRRAKQLQRVVLRATKLERETKVRRANEVDRIDRHLYFVHGLPSDATSLSLPELHALLGSYIDRNQSELANLAAERESRGSWRKTEGKGKREVEIEKQREAEMQEYRTGFVLPDLTVAENVAICRQWINPAPAKETKNTKGGDPSYLGRIRMVRIFEGDKNAVVVAQNGARTEWEQGEGEVEMGSDDDGDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1A7</accession>
    <name>A0A2S5B1A7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1A7"/>
    <dbReference type="STRING" id="741276.A0A2S5B1A7"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018074">
        <property type="entry name" value="UBQ-activ_enz_E1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00536">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="10">
        <location>
            <begin position="880"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1019" mass="112871" checksum="D71409E856C42F1B" modified="2018-07-18" version="1">MNVDASLDESLYSRQLYVLGHEAMKRMAASDVLIVGLSGLGVEIAKNICLAGVKSVTLSDPTPVTVPDLGTQFFLRPEDVGQRRDEATRPRLAELNAYTPVSVLGDFSLEAVKRFTVVVLTQGSTEEQLKLNDFTHANGIKFIAAETAGLFGSAFCDFGEQFPVVDQTGENPLSGMVVEIEEAEDALVTCLDETRHGLEDGDYVRFSEVEGMDINSDGVDGARKITVVGPYTFKVGDTRGLGQYKRGGWFHQVKMPKLLDFKPLRESMTAPEFLLTDFGKFDRPPTLHIGFQALSAFRSQHSRAPKPRSSADAATLVQLAKDIASQAKFEGDLDEKVLQELAFQATGDLSPVNGVIGGFVAQEVLKACSGKFSPLFQHLYYDALEALPTELPTEEECAPSNPPARHDGQIAVFGRKFQSKIENNRQFLVGSGAIGCEMLKNWSMMGLATGEKGQVYVTDLDTIEKSNLNRQFLFRPKDVGSFKSEAARRAVTEMNPGLEGKIEIFKLAVGGDTENTFGDAFFDSIDCVTNALDNVAARQYMDQRCVYYEKPLLESGTLGTKGNVQVVLPHVTESYSSSQDPPEKSHPSCTIKNFPNQIEHTIAWAKERFEEYFEKPAEVVNSYLSQPNFIEAAKQSGETSQLLKIKSYLVDNKPLGFDECIVWARQQFEIEFSNEIKQLLYSLPKDLLTKEGTPFWSGPKRAPDALQFDFNNPTHMEFVVAAANLHAYNYGLKGETSPEVFKKVLAQVNLPEFVPKSGVQVQVKDDEPVANDKDAAPAADADDLASIAAALPQPSSLAGYRMVPAQFEKDDDTNHHIDFITAASNCRALNYGIKTADRHTTKGVAGKIIPALATTTACVAALVNIELYKLIDGKTDIEKYHNAFINLALPLFAFSNPIAAQKQKVGLVEISQYRDTEFTLWDRFFIEGDLTLEELIKYFEEKHRLEISMLSSGVSMLYSGFMPKKKLEERMKMPLSTLVETVSKKQIPSHVRDVVFEIMVNDMDTDEDVEVPYLKVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1C6</accession>
    <name>A0A2S5B1C6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5 6">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5 6"/>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1C6"/>
    <dbReference type="STRING" id="741276.A0A2S5B1C6"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="237" mass="27122" checksum="A7833D7702372FD8" modified="2018-07-18" version="1">MASWTGASTVTVQQAKKQLRTRIASRLKRIPSDSVHAQCWNSANSLGHPHAAEAVLARLFASPYWTSARSISCFLSLPHSEIQTDSLIRHALRDGKRIYVPFCPVDDKTVMRMVRLTDLDHFERLEANRWGIREVDPKEVESLEDDSDPEGGLDLLIVPGLAFDPYRRRLGHGRGYYDRYINQYCLDYPRRFEGKKAPPRTVALALREQMVQADEEIPTNEWDRLPDSLITPDGIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1N1</accession>
    <name>A0A2S5B1N1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000098">
        <property type="protein sequence ID" value="POY70698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1N1"/>
    <dbReference type="OrthoDB" id="2530476at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="576" mass="63127" checksum="BC796EE7D02302D1" modified="2018-07-18" version="1">MPETGSHKVPRPITGLLAASRTDQTPAQPVAGPSNAHLRHRYTSNNNTPAPNTGPHVRPTGTRSRDEQDGDAARASKPMQPMSAFLSSSRAPAHARDRASAKKEATRPAREGLPREATPSQRTKRVLADSDELQEWQKEAARVLQRKQRRFEPAPADESPREEETEAVSKGEQPVAEGREEPRKKAMQTLSTLRGLKLPPPPKRLKPPDAPLTKNDRSSVKRPPAAIFDLSSLAPVSLPTTRKASRPPVSPRNPVRQAEPLSRLSALIPPVQIRREGAQQPERKPAQALTSLKPPPVSEIALGNRANEEVETEEWSPKKRKAGYLASGMAARASSLFASGKTEQTLWLHDFSRRLTGLGPTVLPSLQAAVEPDVRVVVLEVLSFGSDEVDSFMMPDRRRERRSTLATCRLIQEPTRAAANTDEGDDWFAAPTRETQGVVLFSLHDQLGQAGSGSARSVPRPSPTKHARTNNLAATPSPQKNRERSLAVPAIPPDLRLIRPGAEVWIWEPFHEVQLVRNDDVGFDLPREPVEAPEPTQEVPSSQDDGPAIVWVPQTPPGGHLPLKKQEPEQVARKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1R2</accession>
    <name>A0A2S5B1R2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1R2"/>
    <dbReference type="OrthoDB" id="2527297at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="541" mass="59699" checksum="3547878C1C79FDDA" modified="2018-07-18" version="1">MGGAVIPLDRAVYCASPDAVAECIKLCPAAEVVSIGVRIGTYAQCLAYYILVLVAPDEGGLYLVSPSGSMIARIRWTEQLHTWQGTITLHHTVIVALLSHLPYISTLAGMNSLTSYEVLGPAGVLFLQAGMVVKSLFTLLLWAFCLFAFFVGQLPHWTGLQFRQANCFRSTGLVVWLVPIRPRADGADSSTFDLFLIWSYTFAWFLVLAIGSYWTLIAPCVLVKRGGHLRDPHAKKVKGFPLGVGKEPENLLHRIEGEDRAFAHHGDGRLQESDGDSDSDPANERGGRDWPGHAGGYKRDDDIGSLGLMTVRSLPKGASTASLPSYRSQMPPTPRDAGSSDDASSALTRSASSSGPEDARSGSTDDQKGSTRAGRASLSDSGRRAASPPPATRGMTALSPWSKGLRGSKQDAAARWTRRQIQSRHHFVIWPLVAVLLVFTIVTIEVQMVANDVYSGEMDLDFPGALTLFLALPTVWAVLKAVKRIQEGRRPTPNERADQTFWELAREKEQKQLAQRRRRRDERERHRRDRRRRERGSDWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B212</accession>
    <name>A0A2S5B212_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6226</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B212"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="524"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1 first WD40" evidence="10">
        <location>
            <begin position="527"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="652"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="8">
        <location>
            <begin position="970"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="9">
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            <begin position="1280"/>
            <end position="1378"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="1766"/>
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            <begin position="405"/>
            <end position="432"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
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        <location>
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            <end position="29"/>
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            <begin position="84"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="157"/>
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        </location>
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        <location>
            <begin position="183"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="261"/>
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        </location>
    </feature>
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        <location>
            <begin position="272"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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        <location>
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        <location>
            <begin position="1456"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1468"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1518"/>
            <end position="1529"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1542"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1565"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1673"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1698"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1721"/>
            <end position="1732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1766" mass="188055" checksum="87B0CCCA60540E3A" modified="2018-07-18" version="1">MSLPPKPSPAIPHASLPAPTSPAALPSKLKPTGLPSRPTAPLGATTTAVAAEDREEGEETDEHSNAGRSARAESSTAAAPLGPRDGRRPPAPDRGRRGSTPPGLRGGAYRERDRDDRERDRFAARPGPPPSMIGRGARDRDPYWDDRRGPPGGGRGRPPSRSISPARSFTSRGSWGRSRSRSPGPPRRGGPPPLPYGRGGGDYRRGPYPDSPPGGRRRFSRSPPPYARRGGRSRSRSPPRCIGGTGVAPPTGPKGGFRPISSQVAASSSESTPVAGSFPTSASNSTLGGIPTGPRGSNNRFAAPPTGPRALSGAASGGSAAAIPTGPKAWRSGQTAPSGPLSSLSSHAPVPTGPAAMRSREHSPSPPPSASASRPPSAPRAVQTAAAKTRSPTPPPPPPPTEEELARIAAERERAEAQAARDRELRESVRRRQILARYLPRSANGLLVTVPGLSQAMLASPGQDYEAEIQRQREARRALLEPYHAELVSQLATDASLQLAQLDVEAAREHEAGKMAANNAKLVVTPHADGVARLAFSPDGRFLYTAGYEGLMRIFDARLDGEPGSEPSIIDYHQEAVTSLAVSNEYLASAGETGEVVLHKAGQTELDGFLTRFSLPARSVRFDPRGKRAVVTSDEVIAKVIDVKEPTKIQLLTGHSRSVREASWSPDGHFVTTSSVDGQIRVWQLDSGTEPTCVQVLEGLIKAEDAESEYSVEVVWHPSGKFFVVPGKDTDIAIVSRETWQKTGSFADPKGHTGRVSSVALSANGLYLASAADDESDILIWSVKDRSIVARTPHAHGLITSLAFHPAPGANSLAYIDNKGQLTRWQGPVPSSLPAPTHAKQAAKAPTTSEAESSKAANKAVKQGGRQRSLSASTTTSSRADGNLFRKDASEDEFDDAELDDALAGWIDDDLAEDGPHEPDVADDADPFADIVPVRAEAKSGGFGRARSAGLAARTFARSVGAARETGQPPFQVGATPWREQRRYLAFNMIGYIYAVEREEGQAVTIEFHDRSSHIATKFDDRMKYNLGALGELGAVFSCPALGDHASQVFYKPYESWTSLQTWSAPLPVGENATGLAIGGLGQAPDAAAFDDPTVGLTGSGTILVATSRHFVRFFSGAGLQKYLWNVGEEIVTMAAAQDWAIIVHRAGGGGAALDYTLLDTDTFEIVQQGKLPLQQSSSLSWIGFTNDSIPVMYDSKGLLSILDRSRRPRQGRWLPLLDTQTLSRREGKQESYWPVGVSDGNAQVVILKGGERFPHFPTPLLQDLELQMPFANLEVPQAQLAERYLRESVFVQHRKDGAPADDFRLKTELARVELQTEKHLLQIIQTFCKADRLEAALDAVLLLNQPASLVAASKIAGFFTLPALQERVELLQQMREEAGDPDAAAAKRQSKWSHLADDRYITSGSAFAGASTSAAADLFGPASSEAFGARKAFGTPSASMMSAAGTSTSRKRASGAKGAPVAHAAADSDDIGPEVFDDDDDLEYDGDGPVSSPKRMRMDSEEHEEELDAPAPPPPKKAANPFAKRPASAKPPPAKAANPFSDKKAGKAKDLGRTDSFFNRVEGKAPSKGKSKAAPAAGSSTSAPKATKSKTLPDGKQTTLFGFAPPRADEAAKKSGKKRKATPEDGEAETTAKIASTSKAKLEAFRSTQKPGSAATGGLGAEVARELPREGEEMEETQLVDEEESQQMVRKDSELQPVDEADEDDTQMEETQLESQPAHSDSREKENERPATEVMDGSRLAQFAFKKTETRGEGASGEEAADEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2A3</accession>
    <name>A0A2S5B2A3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2A3"/>
    <dbReference type="STRING" id="741276.A0A2S5B2A3"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015777796" evidence="2">
        <location>
            <begin position="22"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="518" mass="53118" checksum="E2247AFF389AC1EA" modified="2018-07-18" version="1">MRLYKLSLSVVLSLVASTAIGAVDSSRKGFARERRLHGHAHLAARSQHLSGAYSGAGATQKMSASSYTVPAATSSSSMSASPVATNSISGAASYTSPASDGSAYATPSLHMASATTTSGLAPVPSVSSTPPSTDLVVLQLAVVLEAFEGAFYRQGLAKFGLADMMAAGLSRVQAFIVIEQIQILAIDEDAHLQALSSAVVALGAQPFTGCGYDFSKALADPLTFLSAARIIEAVGVSAYLGAAHLLKSADLLEAAASILTLEARHQSLLNVLNGGSFNPQSFDIQLTPQAVLSLVGGFLTGCQATNSPLSVRSGNPDGTFQAGTQLVVEVMDVTVQIEILFCQIIVGGSSIALVMPANSCYIPTGIDGPVAVYLTKDNTPLATNVVIQNQLTIVAGPGLIFVDEKITILAALLGPSSQARAENGGENVSRTLPCANLGGWAISTMRGADQSTTNGTTSAMPSSMVASYSAAEGAAASVASKPDMAGAPASSWSPTSPRLSGTPYRFGRRRRTALHRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2M0</accession>
    <name>A0A2S5B2M0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2M0"/>
    <dbReference type="STRING" id="741276.A0A2S5B2M0"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF8">
        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="142"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="445" mass="49208" checksum="F3A54470EEE8A4E3" modified="2018-07-18" version="1">MIRRLRLGAAASAFVAVLIHCRWVLLNGTSVPYRLWTVLFGAFPPFLWTFLFKQAKHIPTEIRPPIHINLLPAANRFLLSPIGVILLTFALLPLARLVYYWSEGDKVKAERGRGRWYAASILLFPFALWATSELGKLEISNALDLFAFGSYGALHFASPIIAGWWIWGFGTQGAACTFGWTLGAQNLAGLATHLVFPNASPWFYDVYGIDAAQPDYTYPGNPAGLVRVDSILGTHIYTKAFGKGPVVFGAIPSLHAATAICCSLFVIRYSKNYRGLIFAWLYCFWMFWATQYLHHHFAIDLLAGTFYSLVSFTLFERVRLRKLDRRHYSEGLTNGWERLWYARRDGENYTPYGERMLARLAGDSASGNGIALSPSISGDSTPVRGTSPPAYRAGGYAAVPSSAAADKEAKGRGSDSFDGTLDDRPGRASVEEAVEDPPRRVASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2R3</accession>
    <name>A0A2S5B2R3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000091">
        <property type="protein sequence ID" value="POY70981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2R3"/>
    <dbReference type="STRING" id="741276.A0A2S5B2R3"/>
    <dbReference type="OrthoDB" id="2530332at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="508"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="845"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="962" mass="96671" checksum="B0FE604AC244ACBA" modified="2018-07-18" version="1">MPGSGARSHSHSRRPHSLTQLTTTTSDCTVTPSSSTHSSPLDASAAAMQDSASNNKLLRLQVLDVSSSAVALSVWTKPTTTLQTAASAAALKPPCISVQLDRRPWPHVAHAGSGTGSTSTPLGSTTGSDSSSSAAVTSTATGTAAAADEGETTVIVYGLDPEREYEISLQVLDGSEDDPQQQQQGGGGSVTEGGPGGLLASVDVETTTGGPATPGSRRGSVDLTATTTTAGGGGVAPSAAAAAAANHHRQASSSISERGDLQSDAMSTTAAPGGPGTGTGSGGAGGGDDDAPPPYSPPTDSSSPYNNHHHHHHSSSLDHNTASSSSFTLAAASSDHSASQASPGSVLIDEPSLRAALKSLRTTSKRNESALQTSLASLRRAVDKASKEDQRARTRIQSLEEAIRKAREAEDQMRDQGTREVEQRLDEVRRLEEEVRDELEEWKEGKREVQRKPSAAAEEGASNAAATVEQSTANDVPTAAVVDDHLDSPGGAGATTSTTTTGLEGLGLADLAKELDALNKAIDAAEKERHEKATEVLKAIEREMHLVEGELIQLDRDEAHRYQMAARYHHQQQQHTAQLAQLDPAAAAAAGLVPTGMPVLPVQIPIVAPAEAPSNSGSGSGGLAGFWKGRRGQSAGNAAAVAAQGGQQQQQDPRSFGRFFRRNASGASSNAAAAAANGTQQAAASGSSINVNVTTLPPSASETDLSSSLASASAALIPSQVILPPTPPSASANASASDRQIAAQQFAQAHQAQAMWAHAQAQAQSHTGAAGMSMRGPYGAAATTRGTTGSPSISPAGLRSRAGSLTNPIGGSAGARPNNSSPALASPAAAAVTADALPPPVPETGNGAASAGGLAGSNPATPASEVAPSSAAAAAATASSPTAESRNPSKKQSSSRDPTGDGASIASSKSGGSTSTSASGWARLGTWSQVVGRGGAKALSRSKSKDGNSATVDDGEDDGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B381</accession>
    <name>A0A2S5B381_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B381"/>
    <dbReference type="STRING" id="741276.A0A2S5B381"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="92"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="92"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="277" mass="30106" checksum="E2EE38CB9971B90D" modified="2018-07-18" version="1">MADKKAAVVKALQQLGATFKQLSRAQADANEAVLDYANAIDKADDPSELLASFPNMFGDIATNPSAARGTNGDVIPKKRGRKEKKEKDPNAPKRPPSAYIEYQNSVREDFRKQYSDLPYSEVLKKIGLVWQGMTEAEKKAWHDITEKKKHQYLADKTAYEGEHGIAPVLPAPPKEPKKRGRKSNAEKAAMAAAAAAAADIPVVDAKKKKSILPGAPGLEADFDYDSQQPESESDSDDSDDGEDDDEDTSSESESEASPAPVVAPVKKDKHKSKKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B490</accession>
    <name>A0A2S5B490_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B490"/>
    <dbReference type="STRING" id="741276.A0A2S5B490"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="73"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="316" mass="35570" checksum="F540FB55136C41CA" modified="2018-07-18" version="1">MESSDPTSTMDKPLGELTDLERADLAARLRDEQSQRVPLVGRLEPLENLREEYKRGSTVFVNKIDGLIRDGWTGIRRTRGDGDCFWRAFVFSLLETYLALHPSHSVYLFEKFSTLLPLLTACGFEPIVWEDFWEPLRDLLWKMGPEAKDGGKREDGEPRLTREGLFTAFNDQETNSCIIVILRLITSAYLRTHEDEFSPFLFALEDDPRFLQDGPEGGVTMRDFCERRVEAVSQEADHLAIVALTRALHVPIRIAYLDQSVLPYTGDSVGEGGAEAAEVNFVEFEEDAAKSGEKGIEGALLYRFTGSGGIDQLRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4E0</accession>
    <name>A0A2S5B4E0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Allantoicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4E0"/>
    <dbReference type="STRING" id="741276.A0A2S5B4E0"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="7">
        <location>
            <begin position="46"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="7">
        <location>
            <begin position="238"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="634" mass="68328" checksum="3641F25904B1A9E1" modified="2018-07-18" version="1">MTATATTNGFSSAASASAGKAAQRVALDQFDSVFGSLIELSSDALGGQVIDVSDEFFCSASNLLKVPPSVSMKGQFGPNGALFDGWESRRHNPTYDCRRTIIKLGALGSISGFDIDSGHFSGNESPASGVWGACVPEGQTLKEDSQLVSLASINRIQARQKPYITIQWKPLLPITPLGPAQRHLFLLPSASEPVTHLKLTMHPDGGLGRFRAYGRVIPPPAPAHPDGKAVDLAYVLNGGTVTGESDQHFGRGGNLILPGRGKDMGDGWETRRSRGRLGTGKGDWVVIKLAEPGYLEWVDIDTLHFVGNFPNAAELYGISSNEECPNVEDPSWTRILEMTKLGPHRQHFYQLAHPEKPWTHVRLDIHPDGGVKRLRLYGRPQSQYPDFSALVPLPAPTPAGVPNGTSATNGAKVNGISKSSRASVPKIPSVPLNPSAFAPYGSVIQSYPDERAAPKEIKIKTVNFGTARKFNHLSPVEYITPPAGRFTTADGSPVPAGQVNFCVFRCEPQNSQQLSADGTGKRQWNVEVLERHEFSSQAFIPMGGTPVEDGEGKYLVLVALPGSDGQPDLSTLRAFTATHTQGISYRPNVWHAPLISLGADKHDFACVVHETGVPEVDCEIKWFDEGVVAVVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4L4</accession>
    <name>A0A2S5B4L4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5346</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4L4"/>
    <dbReference type="STRING" id="741276.A0A2S5B4L4"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="499"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="679" mass="74272" checksum="8C38B7F1C40CC95B" modified="2018-07-18" version="1">MATTKRATEGKQKQRKSKKPRTNRKQAQAAAELDSAPAPLGATSLLAQHAQDYAKDETELQLEEAVFGRRAGTRDADVYDLAEEDFKGKRRAVDGNAGSDDEIDYEAEQEDDDDEETGLERLRDDNILLLILTLSLIVETQLFFVDVPPTASTSNGGPGGHEEDVGSDDEAGSEAEESDFEEGASTAAVQKKPTLRSRNLRQAAWFDPADEQLQISLLGQKRTRKLRDGEDEDVVNGLEYENRLRRQFEKMHPPPQWAVDARRKILRRRAAEAKHGGNAALLIDSDASDASSNEDDGSADEKDEVDDLFRKATFGGKGGKKVKGGKIEPGEIDVDRVRDANQHEAKSGAIVEVGFHPRAQVLFSATSDRRLRLFQIDGTDNPLLQTLHLPELPITSAAFHPSGSSILLTGSRPFFLSYDLQTGQTLRSPRGLLNAGLGGSDKQSTGGAGGLERFRFSPGAGDVLALAGRRGYVHLVDWSSSGVSRGGQVIGEVKMNVAVKGIAWQREGRELLTLGEDSEVYVWDIGTRKCIDRWRDEGGFGSCALETSRDGNWTAVGSTTGIVNMYDASTKGTYAQGAERKARKAIENLVTPVTTMRFSHDSQLVALASKSSKDQLKLVHLPTCSVYQNWPTQQTPLHNVTCVDFSKGSEYLAVGNQRGKVLLYEVKQFARGSKGRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B534</accession>
    <name>A0A2S5B534_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Polo kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5206</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B534"/>
    <dbReference type="STRING" id="741276.A0A2S5B534"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="152"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="9">
        <location>
            <begin position="748"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="105713" checksum="DBECB27CAC9420DD" modified="2018-07-18" version="1">MLQNPRPFAQPGYSRPSAAATSSSTLTSRPPVPLIRSSTSASLAQMSNAPAPIQRQPLAAIQPSRVTDSLAPRPQKPVQAATTRRSTSPPERPAPPPAAATAVPNRVPAGQLLQAGQAPAKEKEKEKEKARSKLSEQWAEPPKRVRREDVWLDRGQLLGEGGFARVYLCTEPDGVTYKALKVIDKQQLKSTKTKSKLFAEIKIHQAMAHANIISFEHCFEDDGNVYMQLELCANGSMLDVLRIRKRYSEPEARFYLTQLVGACDYMHSNSVIHRDLKLGNLMLDQNMDLRVGDFGLAALVKFPGERKKTICGTPNYIAPEILFDQQGGHSFEVDIWSIGVILYTLLIGRPPFQTKDVKAIYKKIRDNSYTFPADHGLSDEAVDLVTWILSPTPAERPTLVEILAHPWFTCGPFPSRISSRALDPERSVGLLEEWRYVSKKQAWENFRRCKRRAGIVELEGGDASQGTGADSATPAPAVVSQALPAVAEAAEEDAEQDAAMAGPTSSGAGTQTEAIKRSKSSMRIVRAEEEKDAKGRMEKEVRSATAPESPISELLRSARKPLLVSPASRGIVRAQPPPERRQIISTAGTLQQRLHAAAPVMIQPAASSSSGTSIVPASSNAGAPSASGSSTRHPPRQPDFERPRTTSGSSGSTRSGSQKESTGDDAPNTPRPRHRRAGATAQATVPVPAPTAGGPRTTVHPSRSLYDATWRSFDAFLGCKATADVAAVSASVIDSLPSDEAQQAPRVFITSWVDYTHKYGTAYSLTDGTAGLYFNDSTTMVLSPDKEHFDYISNRKDNVYTRRHYSISSKPEELDRKAYLLQYFEDYMAKTLRRDVAWLFEDVERKKNMDFLVKYYRMKQAIVFKMSNDVLQFNFYDHYKLIITCSGLLLTFIDPNFTQTTFTLPALFRLAAAHGHYAPRHAPSEELKRIRVFLEKVGYCRDVLRTLVNRKSSSSAAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B537</accession>
    <name>A0A2S5B537_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B537"/>
    <dbReference type="STRING" id="741276.A0A2S5B537"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="62"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="137"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="459" mass="49829" checksum="D6936E1964714A01" modified="2018-07-18" version="1">MLAARTGALQATKRVLPQATRSLSVRTLAAASTRVSFAPVLPALTRSTPLRQFSASCRRADEELVKVPSMAESITEGTLKQWLKQKGDFVEADEEVATIETDKIDVAVNAPKAGVLTDLLAAEEDTVTVGQDLFKLDTSASKPEGGAAAPKEESQPKEEKKDEQPKKEESQPQKSQEANPEPKSEYRKPDSSQPAPKPVEQSKRDSSASQEQQQPAPGKFSRNETKVKISRMRARIAERLKEAQNTAASLTTFNEIDMSALMAFRAKYKDQVMKEHGIKLGFMSAFVKASTVAMKELPAVNASIVGEGNSAEIVYRDYVDVSVAVSTPKGLVTPVLRNAESYDFVGIEREIAALGKKARDGKLTLEDMTGGSFTISNGGVFGSLFGTPILNTPQTAVLGMHATKDKPWVDSNGNIVVRPIMVVALTYDHRLLDGREAVTFLVRVKQLIEDPALFALHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B587</accession>
    <name>A0A2S5B587_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000065">
        <property type="protein sequence ID" value="POY71926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B587"/>
    <dbReference type="OrthoDB" id="2530009at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="218" mass="23331" checksum="D954CEF1E1F27876" modified="2018-07-18" version="1">MAQPHYDYSSDANMSQMRDDDASGYLDASQAEVTADISRQAGAHGSGATARAASPADSSSASSVADSLAHAPAADVEARAQELLSQPNTSAVPARPDPGFGWDAVPREVPTRPDERDQGRQRARDFIAKMLDEADRDDWMYEMPAVFGPPRPVQVRDRKGSGVGTTEATLEAIEAAPAKAPWQDSAFNLESYQVDDAEPNWDGFDAAAYERDDLVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B597</accession>
    <name>A0A2S5B597_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000065">
        <property type="protein sequence ID" value="POY71936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B597"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="530" mass="59298" checksum="5E0E5A86E6D95DE0" modified="2018-07-18" version="1">MSKDAAAAAGIGSASIYSLPDERIEDILRTVVDDSLSRQTGINTLLACMRASRRIYLIGRGILYGEPKPTHCLAPAGPGNECNSSVQPRMLLSGAEGAPNGMFVGLVLKHLWLLCTVESNTVLAGSVRRLDIQAAFQHLEDYAAGVPSEMAARSTSEPLSVFDWQLRMLRTCRHLTHIGVVLRDAEQSRETGEALAEMRDLQSLTLYSRGPRQPDDNPILTFMGRQPRPSASDCERELAIFEAFFTGLGGIHPRRIAQISLRHFQIFDSPNGPTDSDLGRVVSSVTDSVMISVTHLYNFSCLRTLLGPSSQLHQLEIMVIWRTRLLENDESAFAELKGNHLTSIRIFKSFDASGATLANYLYPNVAWRPTYPNRLFRCFLHLRQLSLRMSYGMSLEKLCLLAATSPDVERIDLESCIWIIPFQEQVNYREEDDDDDDDEEDGDERVYDFAQFEEDLIGVFDRWTALEYAHLGLMPHARTEDESAASSDAPFPTLAQWTRSRRIKVEWQTLDPPIEGEGEPSESAPELVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5C2</accession>
    <name>A0A2S5B5C2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isopropylmalate dehydrogenase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000065">
        <property type="protein sequence ID" value="POY71935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5C2"/>
    <dbReference type="STRING" id="741276.A0A2S5B5C2"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="505"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="416"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="314"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="854" mass="90998" checksum="48683A3C4AA1657D" modified="2018-07-18" version="1">MSLRASLPRLASPATITRRVVRRRHRHRHLAVVDSNPFSTTTTTGASSTGKIGASGAGGGDSSHGSKRATAPPPPPAAAAPVASTSTAPAPTPATAPAPASGQQQAQQRLKPRDRLQWIEDKNGSVLSPTSLSSSTASTSSGGKGKGKERQLDPTDTQQQHLGGEVPDSETYADYATSSSRHPFDDSTSPSVFAAASSSSSSAQAQDLGGGELIIPPPVPGLPPLHTHRLPVRPVPFSTRKFVKDLELNGGVEREMAQVIMQATRGLLTSREAKAKEAVLNRQDLENEAYLFQAALAELKTGSQVKLRNDSITLRSLTANLQRETDGLEQKMKEDMQRLASDIQLEMNTRKEETATELQSLDKRVMDLNSKFTILLSEVRTEIEATKWVSTRRVMTAITITVVVLVAYFSVNKSRGGGGGKNGSSSGSGGDKKRNRSRGGQAPSDAADDSSSSSSSRDGGVPSIEELGVTPTENEAEVVYGLTTHPLAGKKMAMQALRESAKVLKIGMIAGDGIGRQVLPAAQRVLEAVPGIPKPTFVQLDAGFEHFQKTGTALPRETVAALKSDCTAAMFGAVSSPSHKVEGYSSPIVALRKEMDLYANVRPVKSVENHDARMVDMTIVRENTECLYVKQEQIEETPQGRVARATRQISERASTRIGRMAFEIALAAAEVKKQRGGSYGWTGAPTVTVVHKSNVLSITDGLFRESVRAVAKEYPNVEVNEQIVDSLVYRLFREPEKLSTLVCPNLYGDIVSDGAAALVGSLGLVPSVNVGDSFIMGEPVHGSAPDIADRVPSIANPIASIRSAALMLEFMGYVEPAAKIYDAVDDAIRAGKVTPDLGGQMSTDEVTEEVLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5F2</accession>
    <name>A0A2S5B5F2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY72009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5F2"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="341" mass="37319" checksum="0BF630B7969898F5" modified="2018-07-18" version="1">MVSNASLIYAKPPHGAPVPGETIKRVVDDNFDPETVALNGGILVQAKALSMDPYMRGRMRDPKVKSYNQPFPLDKPLLTLAVGVVVRSEYDGIKPGQIFKGMFDMSEYAVVPAQLVKMGRTIENKEELPWSTLLGACGMPGATAWCGLYDIGKPKKGETIFVSAASGAVGQIVGQLAKREGLFTIGSAGSDDKVAFLKEIGYDVAFNYKTTSTEEVLEQHQLDIYWDNVGGATLDAALKNFRHHGRIIACGAISEYNVPEAERRGIKNCKSDMNVVTHSLRYQGFIVSNHNQDQFNAEMPQLVKSGEVKIKEHVTKGIDNGESFLDMLEGRNFGKAVIVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6J8</accession>
    <name>A0A2S5B6J8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6J8"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="628" mass="70114" checksum="A3CF1264B5CD4F69" modified="2018-07-18" version="1">MSHMPPGSWPTKSRPASLEATPTVASLISQMIRFLWLASTGSWRGAVVALVRFIPRLALRVVDIARACIIEAWSPRWHFDASRRQTAMRAQQQLREGLGFEPERWICRTRDNVLAWLARQLEALDARLQQDLARVETAKQDAQPKLADDIAQSQPVPKSNGEARRNLENTAALDDVKLLARTLAHRRGQSLPNLTIAEPAEDPWQGTASACEAASPASPRARERYRLLMASRRKPAPTAAGTVLPLTLVILCLEEMYYTFDEKERLETFRSVALVSRLFYGLARCCLYATLKLSLRDCEDQSLRTTRVMRTLLGKRSLAKHVTGLDLDTLASRPIGRSVMVSLLFDMKHLQKLELTYDRGAKDILAAIATGPPRTELVTLRLTGPIDFVVCVALLTLRDLTRLDIDAKLPDHLSPPVMALKTLSIRRECADSSFYGLTLFSTCSLTTLTITSSDKYAPPHLSYLHHLRQLQIMQPYRDNDSADRRLDNAAHAPYIEDLLLSIKVLFDLCIVAFINHEEMPEAPWPDLRQSCGRILKLLPFALVSLSLTAVTSSVDLNALIAFAKTTKRWAPYLTSIALHEEGKALLPAGVRVEEFEALLEKNGVKVRMEGMSSTPSLCLNDILSRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6P7</accession>
    <name>A0A2S5B6P7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6P7"/>
    <dbReference type="STRING" id="741276.A0A2S5B6P7"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF11">
        <property type="entry name" value="THIOL METHYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="234" mass="25305" checksum="D8EFC96702B21AC2" modified="2018-07-18" version="1">MAAAPTPEMVRIRELIANDPAGGQSPTGGWDQAWKEKVTPWDAGDVQPAFRELLDERWEDVGVSLDSLKDGKALVAGCGRGCDAAFIAQHGIETVGLDLSPTAVEVARAHLAKTPDAPTNINFETGDFFKFTPPTGGFSLAFDYTFFCAINPSMRASWGKRYGEVIRPNGVLICLAFPIDGNREGGPPFSVSEEAYDAALGGDFDKIYSKQPTKLAEGRAAGRDRMLVYKRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6X3</accession>
    <name>A0A2S5B6X3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6X3"/>
    <dbReference type="STRING" id="741276.A0A2S5B6X3"/>
    <dbReference type="OrthoDB" id="164921at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="643" mass="70207" checksum="CD4FDA121204385F" modified="2018-07-18" version="1">MSQRTAAQRPSDSTAYDEIERSRPHSAAADDANPRADRLADARGTNERTALLGSSTSRDYRTEAARDRRALAEAGHPENRKRPWSLRFDLAVAFILLLANGYFLVTSLISFNTPFVANTGLPPHRGSLGLPVWSSFLGCALNTAALFSFVFPHESPLLAFYTAVATAIFAIVTLVLSVAVTQLRVVEGPLTFVTVSLLIVSALHAALSAALTDRYAPILDPPAELDPDYEPDRGCWASCRRGMRALLGFLGISLPLAAAHVGVMAAAVLLMINVIIRSVDASVEQPGQRWKLWSRQFFPELNRGLLQSKGREYRVHLACRGVGLEDPPSFRATAQPVNTTFSALERGSVRRTILVEGERGVPAANDAEWVLRMLKDGDLNSGDVEIRVCFWDRPGYGFSDASSTSAGPHVVSALTQALTVSGEMARLQPPPGLETLDDETADSVRPPSPLARSGFILISRGHATGITSLFAAIHPRLVHSFLYLSPVSPATHDLSPPRSRFLAVPHFFTRKLPAIYTELGIGRLWYALKGVPRRRRVFAYEGERVSGLIERAAVQERHEDERGRESDAARAWERRRGRYPTRPTVVLGKGAEGDGGKKFVDDVVGDGLQEWDAKWNGGKVGCGKGGDAERKCREAIKSLLHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7A9</accession>
    <name>A0A2S5B7A9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BMF94_4439</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B7A9"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 21" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 15" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="977"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1244"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1632"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1665"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1693"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="19">
        <location>
            <begin position="24"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="1000"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="20">
        <location>
            <begin position="1903"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="608"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="15">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="896"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="905"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="126"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="POY72611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1962" mass="217321" checksum="FF7FA80C6E078547" modified="2018-07-18" version="1">MAQNPFSTPALGSEVELDPVACPDLADLPEGIPPLSIEELVPYFRARLLEGIPYSQISSRVTVAVNPYQQIHATSDRALVDWRTEYADLGTEGVRGTMGPHVWAAAQRAYYHMSRTGQDQAIVLTGETGAGKTESARLITKALVDLAAPPAGKKGSKVVSAIPAAFFILDTFGSATTLANASASRFGRYIELQFNDKGRLTGLKGLEYSLERSRVANTASGERNFHAFHYLVTGATAEERQHLQLHGSSAATFRFLSKTRTASQSAQADAVRFLQLKEAFKAVGFAKKAVASIFQVLAAILHLGNVEFVVDRNRNADSAVVKNSHVLETAADLLGVDSAELEYALTNKSTLVGGEVCAVFLDAEAASSNRDDLACALYGLVFSWVGEYLNEKLCREDFATFISLVDFPGPHHGGPASREGLGVEAFCANLASERLQSYVLEQLHEANKAEYRSEEVPLPGLDAKYVSNSETVRLLTNMPGGLVHIVDDQSHRRGKTDTTMLQAMTKRWGNHPSFASRNGDEAQGRPGAFIVSHWDGQATYSAENFLAQNAAAISPDFVTLLGGSEASAGQGRRDGGSSGSGSSFSFVRQLFANGSINVESHARSENTLVAASQKVGPRRVPSTRRPKGRNPFGEQEGENMDDSPTAGDAKVPKHSVVKDVNDSINLLLNTLSTSKSWFVLCLRPNDAQLPHQVDAKLLKHQLRVLGVPELGRRLRNEYSVNLEAKEWWERYSRIPVLRDELPSLGSLTYGDKAARVRDLLGFSEREMGLGKSKVYLSDAAFRYLEDFLRAEDSDEQMHLHELVTRVTAAMAPMDPYSSHLHLEAPGLDAYNDAYAKTTSTAALPLVGYRPDQDYEDEAEYDSDRKAYLAGEDDYLGQTARHLPDEEQSLAPSAYTSSRPMFDARGMPEKSEMSSKGDDGLNRETVEVIRMSKARKRWVTLTWIFTWWIPSPFLSWCGGMKRKDVRMAWREKLLINMLIWLLCGAAVFVIAVMGRIICPTQHVFNTEELSERSYSNDQSHMLVAIRGEVFDFSAFAPHHIPGPSVVPTTTIEKLGGQDISDYFPVQVSALCNGVDGSVSPWVTLEAQNVSTAVKQFAQYHDFRAFTGDSRPDWYYETMIYLRYNYRKGFMGYSPGNVKSEVKKHGTNLAIMDGNVYDFTTYIQNNGGGLEVPAGATAPSGTSRLFMSEAIVDLFRQKAGSDITNDFNQLNLAPDVIQRQKICMRNLFFIGKVDTRNSAKCQFSQYLLIALSSFMVVIVAAKFLAALQFGRKRKPEDYDKFVICQVPCYTEGEESLRACLDSLTKLKYDDKRKLIFVICDGMIVGSGNDRPTPQIVLDILGADTSVEPEPLSFHSIGNGDKQHNMAKVYSGLHEAGGHIVPYIVVVKVGKPTERHRPGNRGKRDSQMLLMRFLNRVHFDSPMAPVELEMYHQIKNVIGVNPAFYEYLLMVDADTTVDPYGLNYLVGGFVEDRKIIGLCGETSLVNARASWTTMMQVYEYFISHHLTKAFESLFGTVTCLPGCFSMYRIRTLEHRPVIISDAILAEYGENKVETLHVKNLLSLGEDRYLTTVILKHFPQYKTKFTRFAKAKTIAPDEWKVLMSQRRRWINSTIHNLVELLQIDRMCGFCCFSMRFVILVDLASTLISPVTVAYIIYLVYMVVGEHKPIPTFALIMIAAIYGCQVVIYVLHRKFEHIGWMLLYILAIPFFSFVLPLVSFWQMDDFSWGSTREIVGEQGKRLLVHDEGKFDPASIPLQKWTDYEEALWQEGDNESIGEIIEASKQQQQQEAASAYGLPYGAASVRGGYEATPYRSGDFGPGLGGGHAPSVAAMSQHELMSMHGYQPAIAPGTLSMADRRQSTTSFFAANAIRQAQMMPQQQPRHSYSQSGDQLLGGYGVAPAAGVRGLPSDDVIAHDVQELLSQADLTQVTKKRVREALEDRYGVALPGDKKALVNQVIAEVLGLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7C4</accession>
    <name>A0A2S5B7C4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4483</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7C4"/>
    <dbReference type="STRING" id="741276.A0A2S5B7C4"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF15">
        <property type="entry name" value="MIR1-PHOSPHATE TRANSPORTER OF THE MITOCHONDRIAL CARRIER (MCF) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="80"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30716" checksum="1E38587B37F5F16B" modified="2018-07-18" version="1">MVPIDVVKTRIQLDPSLKKLGMVGTGRHIIAEEGLRGLATGFGSTAVGYFLQGGAKFAGYEFFKKKLAESSGSYENAVKNRTAIYLGGAAIAEFFADILLTPAEAVRIRLVSDRTYATNMLTGFKRMAAEGGLQELYAGFVPILAKQIPYAVGQFLVNELAHEEVYKRMSPERKAQLTATEQSMITLGCGITAGFAAAILSQPADTLLSQINKGHGGKGSAAKKLIVLAKQAGPIGLFAGLGPRMGVPLNNDLLVRQIMTAGLVSSQFYLYGLIKNALGANAGVEIRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7E2</accession>
    <name>A0A2S5B7E2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Programmed cell death protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7E2"/>
    <dbReference type="STRING" id="741276.A0A2S5B7E2"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="16246" checksum="78B7BC5A3ACD5F4B" modified="2018-07-18" version="1">MSDLDAIRAKRMAELQAAGPSSSASGLPSSLSAGAGPTAGSAGPGGAAGGSGEDAAAKQAAEDERRRTMMSQILSPEARERLSRIALVKPDRARAIEQLLARMAGSGQLRGRVSEDQLIDVLDQVEAMEKGQGGGGAAKSASKITFTRKTAYDSDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7G6</accession>
    <name>A0A2S5B7G6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside diphosphate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7G6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7G6"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="144" mass="16484" checksum="253F1735C6816081" modified="2018-07-18" version="1">MADKLRLQLTLGIIKPSVAAHQPHVQDIMKEIKRSGLEFYGEHRGRFYYPRLVQHAVSGPLVALALCAPDVIQKWRNLIGPTRVFEGQWERPESLRARYGLSDTRNGFHGADSPESADKELNLIFENWDTSWWLEQRSQGADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7H0</accession>
    <name>A0A2S5B7H0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7H0"/>
    <dbReference type="STRING" id="741276.A0A2S5B7H0"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF236">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="168"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="629" mass="68481" checksum="E3355B1E25CB4A55" modified="2018-07-18" version="1">MFSQASTLTSSSYFITPQTDELESLSAFALGTCGRSKASRAMAPPLFRAIHAAARRHRQRKLARSLAAREAEYGVDGEGEALAAGAVIDEDAGSREANGNEATERCSTDRLVPGVDKPQPSQELDVGAEGRWIKLPKDRLYEPPEEWSLPEEHGDLAFGGLNEPAALRVIVVGTGFAGLAAAIACARQGYSVTACERSAGISPHGDSILFGANASRILYRWGVGSDMYRRGGNRGGQWVFKQQDGRPVFTQQLSDVVNRYGAPILQGRRSTFLGCLGTEARLLGVDIRLASEVVRYWDSREEPAVVLRGGEVLRADVIIVADGVHSAARRLLTPHVRNGSPRQPSGYSIYRSAIPSGKLRNDSRCSHLLDGTIRTWLGKDRHVCMYPMENGTSIAFTYTHRDVPDQCPASLDWRDRKPIAGMLKELEGWDPVLLAALSHFATSLHWTILDEEPEQEWVRAGGKICFIGDSVHAMMPTAFQGGSQAIEDGAAAAVCLAMAGGRPEDVPLALKVFEAMRRPRVCVAQALGQAQQDIWHEYFDDPSQRDDGARSGTAASLHPISFDLYGYDIEDDVLRHFSEVATAIDVNVHLNKQRTAEAAQKANIAVGVQRLSLADCMDCDVLWEESGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B801</accession>
    <name>A0A2S5B801_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B801"/>
    <dbReference type="STRING" id="741276.A0A2S5B801"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="351" mass="39059" checksum="2FC7E30DC61EEDA4" modified="2018-07-18" version="1">MPVIEKGSLVLISGPSGYLGAHCAEELLKHGFRVRGTVRSQDKGEYLVDLFEKYGRDKFEYVIVEDVEAPGAFDKAIKGVDAFLHTASPFHFNAPDPYKDLINPAVNGTLNALKSAKSEPSVKRVVITASFACIVEPKDPGTYVFTEKDWNEYSPKQVEEHGKDAEASQSYRASKTLAERAAWKFVEEEKPQFDITTIQPPLIFGPVIHQVPSPDKLNTSVNNFYQFLVGNKSAEDAQNGFGSYVDVRDVAKIHVESLLNDHAGNQRFLVATTDSSYQPLLDTYFNNASDDLKSAFPKAQQGKPGNSKPKANTIDTSKAQKTFNWKPIAEKDTVIDMVESLAKYQKERWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B802</accession>
    <name>A0A2S5B802_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B802"/>
    <dbReference type="OrthoDB" id="2521892at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="164" mass="17895" checksum="7A803DF061E3F9C6" modified="2018-07-18" version="1">MPVLDAYNYSLLSVPAVWLLGISTHWTAIFLSAKSKEIPMFDNVAPRQCLAEIQKLAKTSKDARQYLRTEAAQQNIFENLGLYAAAIVAGNVAGLPVRHMNKIALGYLVSRLVYVVLYIKTDGPKLTPLRSIAFLTSPSSHPCTILSLGTFVRAGTAANKLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B825</accession>
    <name>A0A2S5B825_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B825"/>
    <dbReference type="STRING" id="741276.A0A2S5B825"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="228"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="708" mass="75911" checksum="6613083FFCC9FF82" modified="2018-07-18" version="1">MLSPMILTPSGLGGQVVGADYFSNAPRTCRRRPITPDVLRQFRSRSESRKSESASRRLSSSSSSSSSLSSSSSTSPVSAARFTRCATAAMNHYYQPQEQGFGSPSRPDSHLSSVAPRAPLPGYDRDYRPPGSATDTAGEERDAWGPTSPPRGAGSASWGSSTAGAHFPTTSTTSHQQPHLIPRGPQTIDPHTTRRVSNAASDYGAPEPPLGHGQPGPSSPSTAGPKEGFVRIRILGIDRQKRDMYIKFNAETNLPNFHHSSYRGLSRSYTEFTYLVAALGVTCPQSIVPALPLSQTSAATDEEDDRLIKAAFQKWAVRLTSDPAAIRDDELRSFIESDFGYTARTKKKSSTGFSFSRSSRLPGEIEDPLTAAKVSMARLETVFADTAKTLDRVSKSRRTAAGAVHDAGEQTNTFALAEPYAPLANGFKRLAHTLKADADLLASQSVSEQITLGDVFLYQSGNAKSAKETLSGRDAVADDHRHAVKASIQKRRNIEKLKSASSLRSDKVNEALEDLDEAQHYEETLARRLQGISTNLQPSLTRHSVDTHADLLSSLLEHARTTLIYEKQRLKEYETMRPEMRAIRRPEAGVIYHTTPAIAAPVGASTGRTGSIGSIASSGAGTLAASTYGNAVAPPQSPTPSRVGAGSVSSPLASADPLRGGGLHAPGSMAQKIEKRSIRNMASSVHVEGDKRQRVDARMAASMLANGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B857</accession>
    <name>A0A2S5B857_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B857"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="862"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1141"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1095"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1357" mass="142538" checksum="7B88CD09D5BBCE4D" modified="2018-07-18" version="1">MADLLSILRGTAPAPAAPSTTRTSSSTSIPTSADPPQLARHDSSASVMSTAPPEMSSGRGQGAPNPLEQLLRTFSQPRPASSDPSNAATSAALHSDGVQQSRAQGQGPLSPTSGTRPSASDSAALLSLLKGNSSSGITSPAPARPAASPLLSPRGGNAKDLLGLLMGGSGPVTPASEAAPIAAVQQPAQESPKAQAAPQVKDVVDMLGLLGMQDAPSEPAPTDSQPAPATSGGPPLPVFTFVSPFDFLESTRSPPPAAQAPQQAEKQTGTSAGEPFLPAAASPQPQQAARTVSSAAARRPLDSAQGAASPVSVASTSDISKAPDSASGHDGNSAAFPQDFLASEYLRSVPVPAPSWAPLGVRLPRRASLPYNAPQHLTISTADPHLEALVPTAPHVTPIALFPVPVAERRSLARRRTAGIWDQGIAYGSAGTGKNRVRVIDRESGAKVLLKGKKEEKEVVELQVEGQSFGDMRRIACVGKEGRLSVWQIPNRFDDESAASQQSIRLLNLANAASPFVLTRFVPGQQTLYAVRSDRVISVYNLTNTAAKPKEIRLIGGGEIVDIAFSPDAAYAAVLTSKSIVTFQLDNSSAQKKTDLVDLLGDDAAGEADQIVFVSPANDADIDSDAQAWPIGLAVSSAFGTKISVLPIQSQSGRLSMAPTPTVQIEVTPPPPSDVEQFLFGQLEYHEKTQSLVVSHSLRGSLFTFRLAFVDGPDGEPVIRINHVLEHPTPAPILSFTLDSLPTADPNSETTDENDLPEGVRAASKIRYGALAVHPGGVHHVALIADQPRHYAETAPKHRSHDSDTSSDGEGMARRMSLEGSIHVSSEVEVTVEEIDIVEVDLGANGVVIEENGVQTVLITASSVDEPDETPTTAEGTPRYPLTAIPSVQSSPRGTAEPALGDLSNGIAAVATPIAELLREDVLPVRTPASDATRDTSDLAAADFAERSSALPRATTGASNNDLATMIAAVVQQELQKQGGSSKSFDRKLEAMEQRLASSFEVAIQLQTTAAVAAAATTVQQVLPIELGRHLAHPDLVFTLSEGVANTVAPVLERTIASRLISTVSPAIERQLSVAVDSVMDSIRQEMLDVRKEIVQEQSGSVSILEDEVANLRAEVSTMKSMLEKMERLLMASAAAAATNNAASPRLGHTPLHAAPGRQPSRQVSQPAPIAFSPPQHSTAPTAIMQTLPPIPRAVTPPARYEELFTDVMLPSHEPEFAGLAHLIMASPLARLEAIFPAAPAAPLLTMPVVLSLAYRLSQLLANKDGPVDDADKRHLLWLRKAVAACDGKQSPEIVALIPRILTNVVENLVTRGRRLMAMNDQAGAGEVRLVTQYAHVRLTLYQQAGAEGPGVETFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8I6</accession>
    <name>A0A2S5B8I6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8I6"/>
    <dbReference type="STRING" id="741276.A0A2S5B8I6"/>
    <dbReference type="OrthoDB" id="2529149at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="746" mass="77694" checksum="D350AE85F88E7DC4" modified="2018-07-18" version="1">MAQRPHAYDMSFLEDAEDEGVPQYEGTSPPSTVTSGTPSSAGTRPPSLLARSPSEKSTSKLVGLRGPPLAYTPKSAEVEAWRREQAAGDGTEEPIPTEQLSQHLSRMLHVGGGDENTKSVRLEDMTDAEIAQHHFRLAQQHLQAAQRLALAAATAPPPQSNAPSSAPSISSASSTSRARPPAPSVDTHARYAGANTPLPAHSVPDASSPLSSYAPSSVASRRRGPHFSGDSYRTANDALSLSPSAIGVLSRLTGYHTASQARTDGSDTISSAPGPSTSAPPSQGPPSLVHTDSSALSTRSAPTSASHLTQRPVPPPRRSTMSSSVSTGAMEHASSLVPSLYGGGLPANVLDRMAAVRSDGPNAEGTLGHPAAAGGFASEADFVAYAASTAGSNDHREILRDDDSYSLAPTTADDTWDDGRSDFYGSESVFSHVTRATLPGYDDALQPVPPVPTIPTRYMATHEHAGSDPREHASAVVGTAISTPPLAAPDEFHGFRPRQTQTSYMHGLSPVPTTTRSSTLPPAVAHMPSAPQSLANVQPQAYVIGPAGQPIPVYSSAAFGPGHSASARPVAPILPVHARPLQFQHALSYTGQPAVVGQVTYSNPNVSAAGPAPTLTSHSSSATLPRPGLAEPVTRPTSAWSDNSDQSNADARSIAAGSTFSRTKSRMASLRAKVPHVRFMSPDPTVLRAPRGTGPARQAPRTGARRSTASGGVATNDVIAEQQEGESEEEREKRQRAIQMSLGMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8V2</accession>
    <name>A0A2S5B8V2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8V2"/>
    <dbReference type="STRING" id="741276.A0A2S5B8V2"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="189"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="450" mass="48666" checksum="67E7E95A744F946C" modified="2018-07-18" version="1">MLRSTSVRQWARLAASTSGPGSPARLFAPALARPSSSSLPSHQQSPFAHSNITAPHSVPGLPDRSTSVSQRPQKHKAKKAKGSKYASPLPTSDAASASAGLLPVGLRNPTPRRRPADGKVIALTTAESYDTAQLLQRLQAMGLLEDAVNLVGEAVLLPRWSPAAATFFDADTAAAGNPNAATLQEQGEVYVFESGTVVLWGLSMDAAEVFLRKVIRGGLGTSNGFVEQGRYAEPETEVLEYWIGQDGPTHMSGDSIHLSSPISEALPALSETTPTAPSKSLLERLAFSAGMARVTKLGVYEEQFDAFAEGVAGIPKLLESGSESPVKKTDIIKRVGTLHSFRQKLNLEDENLLDEPEFLWEDADLHGHYTAVCKALEFENRLTTLNDRVDYAFSLQTTLMELLNAKTSHRLEWIIIILIAFEISLVLIREGLPFLNSHEKPEPKEAAVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8W5</accession>
    <name>A0A2S5B8W5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_3538</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8W5"/>
    <dbReference type="STRING" id="741276.A0A2S5B8W5"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="34"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="296"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY73205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="417" mass="43237" checksum="1AA868B0D2E3DB6F" modified="2018-07-18" version="1">MALSPSPFPHSLRSSRVLGSMQSSSSTATGLREVFIVGAARTPVGAFQGALKGVSAVELGVAAVKGVLAQSKVEPSQVEDLYFGQVLQGGAGQSPARQVVLGSGMPDTTEATTVNKVCASGMKAVMLASQNIQTGQRDLMVAGGMESMSNAPFYTPRTPATFGHHQALDAIVKDGLTDVYGDYPMGNCAEETAEKHQITREDQDAYCLESYRKAADAWKAGAFKNEIAPVTLKTRAGETVIAEDEEYKNVKPEKVPSLRPVFKKNGTVTAANASTLNDGASALVLASEDKVSELGLTPLAKVISFADAACAPVDFPIAPAKAVPIALQRAGLSMDQIAKFEVNEAFSAVAIANQKILNIPTEKLNVNGGAVALGHALGSSGSRIIVTLVHLLKPGEYGVAGVCNGGGGASAIVIQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8X7</accession>
    <name>A0A2S5B8X7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8X7"/>
    <dbReference type="STRING" id="741276.A0A2S5B8X7"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS4 central region" evidence="8">
        <location>
            <begin position="76"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 C-terminal" evidence="9">
        <location>
            <begin position="192"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="244" mass="27522" checksum="6F7A00552D1F25E0" modified="2018-07-18" version="1">MECCASWGSHRGEVGWLTPAYVPSQIFIRNRLKYALTGREVSLVVKQRLIKIDNKVRTDETYPAGFMDVISIEKSGEHFRLLYDVKGRFAIHRISEEEATYKLLKVKKVQLGAKGVPFIVTHDGRTIRYPDPAIKVNDTVKFDLVENKIVDHIKFEQGNLVMLTGGRNQGRVGTLVHKERHVGGYDIVHVRDVLDREFATRLSNVFIIGDGAKAAISLPKGGGVKLSISEERDARRKAQEKQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Z6</accession>
    <name>A0A2S5B8Z6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Z6"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Z6"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="439"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="523" mass="56449" checksum="713723E16A4FE95C" modified="2018-07-18" version="1">MPASPSRKEALDEGPSTIPALQKNLRHAYFWRYSPPSRAIPGLSSRGRTRSLPQLLTGEPADAMTDSLPPIDHLIRRSAKRAHALFSGDLLADDSTQDLRSTKVRLASKIDAEYRNAKVLPAALIAQQKGGVGPARPAGPAAPGVGTGEPQRRMIEGPMAKTVEQLSSQALTTTSQNGGSVPVSHAQPTLLSQSLIRRREARQVKPDYHAPWKLTRVISGHLGWVRACAVEPGNQWFATGAGDRVIKIWDLASGELKVSLTGHISTVRGLAVSSRSPYLFSCAEDKGKTDAMIPYQMVKCWDLETNKVIRHYHGHLSGVYSLALHPTLDVLVTAGRDASARVWDIRTKSQVHVLTGHTGTISTVQCQESDPQVITGSMDSTVRLWDLAAGKTMTTLTHHHKSVRSIAVHPTEYSFATGSAGGNNIKKWACPNGTFVHNFSGHDAIINSLSVNADGVLFSGGDNGSMTWWDYKTGLPFQTSNDIAQPGSLDAESGIFASTFDQTGSRLILGCADKTIKIFSEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B931</accession>
    <name>A0A2S5B931_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B931"/>
    <dbReference type="STRING" id="741276.A0A2S5B931"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="81"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="297"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="527" mass="54741" checksum="A4F6F832F0D76412" modified="2018-07-18" version="1">MTPTFRQLEFSCPPTPSHSFDSTMDQDAFRSLLATPARPSGSGPTPSRFGLAPPKRQPAQHKGASTDLKPRKVTSNASATAKPKRNPDGSLYRDRAAERRAGRDSDFADAERLLEDFKARSETAGVSKDVLEDQMKYLGGDEHHSILVKGLDIALLEREKAKLAGKAESELENVEDELDAAFETAATAVGPASPPLPPAAGPSRQQKASNAGPSTKKRAKTRDELIAEMKAMRAGAAGGGGPAVTESRFKPIGGSSVDKKGKGKEGPTSASGGWKAVGADATGGEGEKKKRKKRKVVPAAAAAEEPAAEPATAPAAGSVAEAAAEQTEAAPAQAPLLPSGPPPVVDIDDDFDIFGDAGDYKGLDTDEDEDAGSAAASNKPPPPLPPVSAAGKRKYFDDDDDEEDAIQTSTAPGGMGDSAAKQAAADAAAQSGRAAGGDGADGQADEEAEAPPMRLEGLSGAGPSVKELLEMDKAAEAEEKRQARKLKAKEKAEARRANMTDADKANQDYQKMMSHLEKKDGNKKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B950</accession>
    <name>A0A2S5B950_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B950"/>
    <dbReference type="STRING" id="741276.A0A2S5B950"/>
    <dbReference type="OrthoDB" id="1718410at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF7">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="638"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="80920" checksum="E35B9FCCE2B99D93" modified="2018-07-18" version="1">MDSQAIASGSGSDSQANVRQRRVGRRPDAPSYAESEWVEIIRRQRARDGTGALKLPPNYTAGSVSPLLDASLPGQTYPPLAPKDPPRLANEWEFSGWGDVSHVELSAEEVEAARVESEEEKKRDGHETLGSWLASGVAGVAVAGSPLYAFPALVTVAGVYSPISLFIATLLLAFWRPIMSDLAAALPISGANYAYLLNASTSVPLALFGAALTLLDDISTSVVAAATASVYITDQAHGVVGAGWMTIVLLSVVTAIGLIGIRGSAGVTLVTLAFHLTTLAVLMLCSVVHWAHHGNDVLKANWQSGQLSSGAEIAKAIYLGICIAFLGVTGFETAPDYASALRPSPRIYPVVLRSLQAIAIVINAPLLLCTFAVLPLDRIMSVSSVLSDLGRSSGGTWLATWVTVDAVVILLATILSGLVAALELVQRVSRDGFLPRWLSRPMPITGVPAFTILLFAILSLLVYVTSSLSLSVVSSLFAIVFLSIMSLYPISLLVLLFNRPTLLGANRRSPFLLIVGTLILSFVLIAGVVVTDPMSIAYFAAYGAALSILAWTAASWGSGVRWAWWIAEHGLKWPVAAKWCVRMIKYARTGRDIVIFVKGDEINQLFRRILYVEKNEDTSHITLVHFYGGGGSAAGPATIDEKASRTSAQADTASMHALDRNARRRHSDAGARSGGPSASAAIPSELEANLTPANWAVLDEAFPSITVDLMLVHAAFSPAAVRALGRRLGVANGRMMMGAPACRDEDGLFGVREFGGVRVISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9J0</accession>
    <name>A0A2S5B9J0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9J0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="240" mass="26911" checksum="D80DC8469CF96E9E" modified="2018-07-18" version="1">MALFDDLLRQVNDFGHEPLRKLLYASVRQLIAEIYAPAYVARHEGLCHYELAAARHQSGSVVEHLFRDPDGNARRQGMIHMPPIPIPALSIAQPSMADSRWTGLTMTNVDLLDPKPLRDTAAGPSIMPLFETQAIGLSNPFTPLHRVIHSPCSLSWPTEAVRDNIEHAGLMGIEVPPFELKVTVPDLNGRMVLYRGTMQQVEDPRVTMRLWPPPAVVHWHFTAEAIHGEKPPLDFIIEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9K6</accession>
    <name>A0A2S5B9K6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9K6"/>
    <dbReference type="STRING" id="741276.A0A2S5B9K6"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Hook C-terminal" evidence="6">
        <location>
            <begin position="230"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="763"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="834"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="279"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="495"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="645"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="97588" checksum="F5CF245B5E688518" modified="2018-07-18" version="1">MSAAPRKSLFSSLASTADHERLPDALVEWVKAQPRTEKGDAAEQGLDGLKDGLRLTEVVAQIDPDFFASLVDSAAAPNTKALADNWILRFNHLKKLYRLTVRYFEDVLRSSTADLLTPNLRLVAKNDLRESNDEVCKLIGLVLALAVQSPKKQEHIARIQKLDEWVQRELMYSIEQVMSKVRPMEIPEEVEAEEQGTNVETDDADDFYTIRHEKSRIMHDKDTLQILYDELAEQFKSLKEEHEETLGSLAVSEAKTVELTEQVEKSKRDRPDVALKVEIERLRAELQKTSTDLGEAEQVVDSQSKLIDDLTRRVDDLEPRAEEAVRLKDQVDELRHASDKAKKQENVIEKYKKKLEEAAETKRMLKTLEEQNADLLDKNASLEDEYAKAAAFKPLLDSYKSKVDTLETKSAALQRDMEGLKLELHRAKEAARKAEEERQRGAETLLAFEERVQELEATGPASTKMRRSDTGTSVDEAEAGGLGLELDDAMGGATMTDLKLRIRRLERELKRTGTNDEAGSTAVMQDLLDEANRLKDKYQQDYLAEHREKLVLGARLDEIASGKSRLGDGPEAVIAVRHRLEQTSTDLDTLRKEHHALQARCTKLDRLLKAAQVDRASHASPPPACATAQADLELLSVSLVDADQLEALRTIRESVSAEKAALEAQVDDLQASLHAAEDKARLQMEEVNKLLSGKVREQDGEISLRDDALKREEELRSARQSHEAQAVEHAARVEALERERDDLAAKVQKMKEFIKQQDKLFRAEQAASTDRQTKPTGDTDLSKLQEENEKQAAEVKRLKAKLAEVEATYRKEQQTMLAAWHDLGLKTMRERVLATATTPTAEQKPYQPQSWLSQQRARAAAGKRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAD0</accession>
    <name>A0A2S5BAD0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.135</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAD0"/>
    <dbReference type="STRING" id="741276.A0A2S5BAD0"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="640"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1032" mass="113299" checksum="F3EB5C877A7B86E2" modified="2018-07-18" version="1">MSYYGGGGGGYSNQGGRSSQGSPQGQGYPGYGGQGQQSFGQGGRFVSPPGRGGGPPNRGGGRGGGGPGMGGGRGRARGRPQYRPAPPRPALPSFAEIEPGSGEFVEPKRRLDFGTVHSHRNGENRIGLTSNAFEISVVDARVEWHKYEINIQQSTRPGVPARSRPSTGALPRRYLREIWIEIERLERAGANNFGGNDPVYDGGLACYTEKPFPQDITIPNIQIASKPRDEFTVRIFNGITVPLESLRNYLTGQGTFHIGQMTEALQVLNVAFRHGPALAFLSTRTSFFPPPGQNNGDEIEISPNFLKLIRGFFAAVRPCIGATQLIINTTSASYLKEGTLWLFMAGFLEAKGVRNPSLSVANIPDVSYIQLNRVLKNVQIEVDRGQSKLRTKIRGRGLVKQRPRDHYFDVDGHGRMNVEEYLLATFQIRLKHSEYPLVEVRAGVYYPVELITIDPHNKYLSRLDPAQQSAAAGLQIMPPAEKLGRIQAVRASHILRQCDPILARFGISIGISPKSVIGRIVHPPQIEYRSPQGGGQNPRLSPEDGSWMMNWAGRGFDQWFIRGAQIRSYAIITPNARDVRRIEEFFEALMQKAALIGMNVVALGNLRPRAIYVRQRGDSVVQAINAADRLAQQAYNAPAQLVVYMFGEANSPDYSVFKFESTRRGIASQALQAQKLAKTRDIQLAVNLCLKINSKLAGQSVRLEANSTSGLKPQQGVLGTPGWLALVKPMVFGADLSHEADKPSVAVITATMHDQAIICAEESSVQPLLEPPSNAAPHARPRKSEIIINAHDMVLSLLKTRASNGSLPPQNLLFLRDGISEGEYGAFIRTEVQEYRRAIESFKQDPDMLKAIKGLEGYSPRLTVVACIKGHHVRFFNEAGTDEQPNRTINIEAGTIVDSDVTSTRSADMYMAAHAAILGTTRPTRYEVLVDENNLSADEFQTTMHSLCYTYQRCHKSVSLPAPVYYAHLVAGQIRQWVLSGMAARAPSTGSSGVSTAASRLQDFNGAQQILNDTHRGRQGFRMSRPPAMWWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAF6</accession>
    <name>A0A2S5BAF6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAF6"/>
    <dbReference type="OrthoDB" id="10371889at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="153" mass="17381" checksum="1F4920048536CA57" modified="2018-07-18" version="1">MLDRLPTELIELVIDAAAASIWTRKATIDRLGLVNKSYRAVTRPLRIRIVQVTGAEGIVELRSWPAWARKSVETVLIGTNEPGRDRTRLFEADINRLMALLPQVKAVFMEGLEGCYRSKLANTDKSTKLWFELEHGNPFRTHTPSSRPRRDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAH3</accession>
    <name>A0A2S5BAH3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3313</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAH3"/>
    <dbReference type="STRING" id="741276.A0A2S5BAH3"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="379"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="496"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="875"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="932"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="935"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="950"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="983" mass="103534" checksum="0F706B6EF2906797" modified="2018-07-18" version="1">MATVLPAQAAFNAKLNRSRPTQKERKLIRQQQQQTSLADADTVAEQDIVEAAVERSDAVPQKGGLDWLPLTDQSPHTCPAVFTPDAAYCFIASGAAVRIYSVRTTELLSTLSIPPSSSPDTDNGVLSRSTITAVLLSPSIPRQLVVTSTDGRVRVWDYVEGKLLRTLEMGAPVLHAAANDKLPDQLFVALAAPEEAGEGAPTANSVVGKGKARAALSASTGRSQVQLAGVYVVSLRAARSATAGTATTSSAAASAPSSPSTPVPPARRVRLAVPRQVRALALSPSGAVLASLTPTHVHLCQTAQLNKGFVKSVDAPIDGERFTTVAFHPTENIFATGNEKGQIRVWYNVLPRPAPTEGGDAQMDWAEADVGAEPSSSVLHWHARAVSSLAFTPNGAYLLSGGREAVLVLWQLHSGHQEYVPRLGAEIETLTVLEANASEGGEQQVAVRLRDGSTVFVGSQRLKIVKTIAGLKSDLSIARSSSAPIAASRTDLPVPLAIDPATSALVLPSGHPSSLQFYSPSSDAQLLELEISPSNRVASANGTVEPTRVERVAFSKPGSAGGKDEYWMATVDSWSREAYASVRQLKFWRKREGQPGFVLSTRIDRPHEAPITSIAFSPSSASPLLLTTSTDGRIKVWGPSSASEGAWQCRASLSYRSSAPVASAWSHDGSLFAVAHTKRTVTLWSVANAGQLVHAFPATAIGRPKSICFADKEGTQILCAGSSGAVCWDLLTLEETFSTSIEFAALVPKPQSSVLIGIEDVAPSSSGAEQPSALLYVSHPSSPLSTSPRKSKTRPLPHPVRQALWLPSLVAGDDDVSLAVTSADTTNSVALVGNAARSSSAAGAGVASRLPIATEGTTRLFDEIFGETDLSASKREARAAASEARPTPAGDKKQVRGGILGTADGEGTPAHTLPPIRMLWREVFHDAFAVRRSASDASPPSQAATAAPDRPAKQAEHDEALQPEWHVGDTETVRRIFAARLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBS6</accession>
    <name>A0A2S5BBS6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2658</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBS6"/>
    <dbReference type="STRING" id="741276.A0A2S5BBS6"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF44">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="945"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1036" mass="113310" checksum="0EBD946E1E659BFA" modified="2018-07-18" version="1">MTSSRPPLWKRLFPTAGRLNFAIQAFSLTAILLEGLDQGNMGGVNASPDYVKTVGIGEYPSGHVTNTVHQGGIVSIYYLGCIVGCFVCGWIADRFGRINGIMGAAVLATTGGALQAATQSSNWILGSRVLTGLGVGALTGIVPVYCSEVSGAAHRGRFLGLVFIANYLGISLAYWISFGLAFIDDGLSAIRWRFLLAFQCVPAVLLVAGIRLLPDSPRYLASVGRQDEAREVLAHIRGGISPETNAELLAMADEAQHNTKASVIEFVKILVGKGSTKLHHNLARRAWLCIWLQIMASWSGITAVTAYSPVLLSQAGYSSIKQNGLAGGLNTIGIVGTIISAFVVDRYGRRPCLMAGSLGLAIVNLIAASLYEASLHKPSIAPHIAPAAVTMLFLFNLVYAATWGTIAFLIPAEIFPSEMRSQGNGYGITGWAIGVGWTVLINPIMFGSIGSRSYFLFAGLNFLWIPIVWLFYPETGFGRNLESLTHLFDSGPFNWQMEAAFRRALEDPERPVNVAKHSNLDAHSFVEDERLDDSFGAWQPLVVVPLEPLLKVLTIYHETAYPIFPFFVWPTFIDKVAREEHLGNRPFYGVVMAAAALALARTRDSATPSRTISHEEAELLPAPEVLFAAAEDAMPKDLTTAEDFDYVRASALLALVGIQFARPRKLQQHLGTYNTLCSVNRSHDERRWGANLTAIEKEERRRVIWSIYTLELFAALSFGGTLRSRQTSIKVQYPLVTDESLISCSGDPSASPASANTTWLTGWNFVTELYKTLEYALDSTQDPSLSSSSSATSILDFLDATYATLPPIFKEMRSFIGDTQYDRFGYQTANIRVTLQTVKMVAVCRDLSEPCRREQAVQIAEILLQDVNAVPLPYLQAISSPLLHHLVGIYKLILPITEHSLTPDLFLRIRQILIDITTLLQRLQSRLTYTTNAIQRFQSQIARMDAAQTAGQSRPPSPSADLDPPPTAAPGSARAGTDDSANLLPWEAAFELHDVFSEWPFDFDGNRVVTEDPLGLFSSEGPRLDLGSAYTGEDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBU0</accession>
    <name>A0A2S5BBU0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_2651</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBU0"/>
    <dbReference type="STRING" id="741276.A0A2S5BBU0"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY74213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="89" mass="10028" checksum="7646F75F8396F772" modified="2018-07-18" version="1">MTTVASEPSAARLAARLESQVLDEYKRTARDLNDIATIVQRLSGIQPQLLAELRPLERKLGLVLTLFKASVWALLRERELVPDEEDEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBW1</accession>
    <name>A0A2S5BBW1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBW1"/>
    <dbReference type="STRING" id="741276.A0A2S5BBW1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="178"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36610" checksum="F714699A70B28188" modified="2018-07-18" version="1">MSLASRFRIRLLTPTQLPAMSTESVPKAVLYWFSGSVWASVPRLTAVEKGFTENELETRFVDLVKGENFSPAYLKINDNGTVPSLVVPYAHTVDEGISTKFKALTDSQEICTFLDQSTRSASFSAPALSPATIQNSQLSQDIIARVHEQGVDPNALLLMWRNEDERKAKAGGLPATFLRGRQAALERYAKEADGQQNNAWLRDFYAKKIRENGGTLALLEGHGDSAQIAGIEQKAKALWQGVDDTLEYLEDQLDSKSPFLLGDQVSLADLHAGAWLARVLACAGAESISEPDAALSALESNLASRKPIGPKTKRWAKALFERKSFQEVYGDGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBX3</accession>
    <name>A0A2S5BBX3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Component of the lid subcomplex of the 19S RC.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBX3"/>
    <dbReference type="STRING" id="741276.A0A2S5BBX3"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="216"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="412" mass="44681" checksum="608B3407567F55DC" modified="2018-07-18" version="1">MASSATPAAATASSVDDGAPVAIPNLALPQLAFVLTEPKAEHKRQGALEKLVQGIQHDEMAPYLETLTASGVIPSHLPSSSTSSSPSSASDLVASLREKNSAELERLSTKLADARTNLGETEVSDALRERAAYLARIGEKDKAVEAHDEAVEKTAGKGAKIDLVLSIARIAMFHNDHELLAASLDRAQKLVDEGGDWDRRNRLKVYRGVHLLSIRNFKKGADLLLDALPTFTASELIDYDDFVVLCVLAGVFALERKDLKKKVIDAPEVIAVVPTVPTIKGFAESLHKSDYAAFFKALATVEEHHLLPSRLLSIHAKYYTRELRIKAYAQLLESYRSVTLDNLAAAFGVSSEWLDADLARFIAAGRLTCSIDRVNGVVETHRPDAKNARYAAVIKQGDAVLTSVQRLSRVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBZ5</accession>
    <name>A0A2S5BBZ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBZ5"/>
    <dbReference type="STRING" id="741276.A0A2S5BBZ5"/>
    <dbReference type="OrthoDB" id="2536813at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="637" mass="66216" checksum="CE997651C57A576A" modified="2018-07-18" version="1">MHRHVKRQDWNSGGSNASGGGSGAGGTTTTAAGNGGGSAAATTTQADWQKTTTTSQWQAPSSTTQAQWSATTTTTQEWVAPSSSSTWSSPAWSQATTTTTQNWWTSSSTQQWTPSSSSTQQWTPSSSSTQAWSSSTQAWTSSSSTANWWDSTSATTTTAAWQQQTSSSSVAASSTSLPAGQATFTSHSTAVVVVDASASASNAAAANSLAANAARPGSGGSNKIATGAVAGIVVGALIGVAALAGGIFWFLKKKMRDNEPDMVSPFDRDAFRRASVMLDNDDDEFGTDSYRNAAGAGYTSHSPHMSEYSMQSLTAAAAGGAMVSRGDTLMRQHQSPQVYQQQPAFDPSQVVPVMAPPAAYAGAAGYPAAAAVNYSHAGPAASLPAPIPHGGEPAGLGAYPTLSRGPSQVSRPAEMLSPGGADLTRRDSQMSEYSQYSDGPDGNPALAIPPVAASRGGAYGYTDERGLPLVHEVEEPYTPPSATNGRFADFQQQQLDLQQRERERAHADAMLLAAAHPEGQSRSGTPENANVQQTFFSSSHESQYGDADSQHRLSGPPAGALPADYPPFDGQVAHIGRSWSAEAGDDMNGDYAAASSAADHHLAGGAGQQHRRRLSVRNGGLDDFDEEDDEQIRAHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBZ9</accession>
    <name>A0A2S5BBZ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBZ9"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="231" mass="26738" checksum="C9B88F5A349D9319" modified="2018-07-18" version="1">MDIVWSTHKLVCGDRAHPFKLPPFSQEEADYIAQQCVVATETPQAEWLQAELRRLVSPTTSEDRAHYQTCCAEYVGLGDTSITRDEPPKLSPNDANRRHKMRTFVTHELRQRSMALYLNTLKMHKSLDPPLLTSMPYNYDTYTQGAPVDKTSKWHSEFCHRLIAVQCYHLKMRVVTKTRPVIVSELLRTTRDVERSYRLLRTFVQTAPNPALTQAATRMINQTLKSFEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC94</accession>
    <name>A0A2S5BC94_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC94"/>
    <dbReference type="STRING" id="741276.A0A2S5BC94"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="59"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="392" mass="42421" checksum="076A8BB19E45660B" modified="2018-07-18" version="1">MASSQRTPPVTQLDPPRHAVVVGAGVIGLSTAIRLLEAGYRVDLVARDLPGDPLSIEFTSPWAGAHHVSVANGADMRLHQFDARTFKVMSDLIRSDPDVPLFFAKQTEYREEPEPTEGPGQHAGQLALMSRYHPNFRWLAPGELPTGIACGAEFTCILIHTPDYLAYLVGRVKHLGGRIHRCGALASLAAALEVDPSLSSADLVINCTGLGARTLVPDAKVFPTRGQLVIVEAPWISQGITRLGPAREGQPRVYDYTIPRPKTGHVVLGGCAEQNNWDPNPRADMTRRIKERCLALQPELLPPDKRTGGTIDDLRVVREAVGLRPTREGGIRLEVELLRTAAGREIPLVHNYGHGGYGFQSSWASAEAAVELAGRSFDGSGMALDRAGKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCB2</accession>
    <name>A0A2S5BCB2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCB2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCB2"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="533" mass="57213" checksum="68E64DDF40336747" modified="2018-07-18" version="1">MATAEAGNSLPRPLEYDVAAALSPRAVDPLLSREAFSSPPTHTSRGPLHSGSTWVGVQRSGRNSYEVTVKFDEVDIDASKVCGTLEIKGLTPELDSLVTFFEGEIVGEVGSPGFRTGRFGATEFDDLKHWRRFPAFTRNRLERGLIKPELNLRTSKNKPYVFLRLKEKHVVNHRVEAIHGASYAGFYYCCLDCEPSIVPLDSQAAPLHRGISPPSRTLMPTRARRTSSAGARGRPEPSLLAQTRPIAPRTPSTSRLSPPPVVVNLPAVPNGQTALPLVAPAPSRPAQPRRTSSGSISYAAAVRGEAMSTSPSLPELSSSPTASTSSGSPVTPPSIPPVIQVSEPSRPASTDLPTPKAEFPEPAFSIFAPLDSTAPSLPPIWQAVAAGPFSPSYNAAHFGQPAGPSTSPTDEEWPVPVQTTSQVTPPPRPPAALRRMSSDVATVLAKAQGVFGERGRSGRIGGRKSAFPYSAADEDFYGDETDEQGGFDDRGLRSWTEATISGFYFHHSASPYQELSLRYVPSYRGGTAEYSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCD4</accession>
    <name>A0A2S5BCD4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCD4"/>
    <dbReference type="STRING" id="741276.A0A2S5BCD4"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="403" mass="41721" checksum="7C257CDDA94E16F1" modified="2018-07-18" version="1">MADSKAAVPLRASPEVMSLFSPATSLSPIRIFVSLSVLLVFLLVAFFSPVKYNKGRSPVAVRAAGAKGKTRTVLLVGPLAAGKTALFSKLVYGHVQPSYTSMKENEAIVSTKWTEITEEAEDDKHELVDEKARLETPIHLVDIPGHPRLRTRSLAQNLPAADGIVFTIDGAAGLTGKNVRDAAEHLHVLLSLLALNSTRQLTLPPLLILLTKSDLSGSSSGTASSTSSPSVASKARSPILTLERAKQSLLRELERRRLAATGGGSSFPGGGANAHSAPLSAGAKLEGLDAIPLSSSGGNGGRTGVLGAILSLFGLGGGSGSGSSGLAPMPSLTDSSTLSSSVALPSDENELLSGAADDVFAFEGAADWDKLANAVGGIEVRWQVASVVDQRGVDGVYEWVQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCF1</accession>
    <name>A0A2S5BCF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCF1"/>
    <dbReference type="OrthoDB" id="2530449at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="319" mass="33359" checksum="637BFFD4512A8436" modified="2018-07-18" version="1">MAPTQTAASTSTSASGRGAPQRPAPYPLGETDRSQTRRRRRVSSLAADPALDTLGALYVGWAQGERDPAPLCCPQRAKQSLVRKYGNAAVGSYSDSVQSFVNSATSVHARAKQPHLDHPPSSAGLQESGSSGDARAHANYGQTAVPSSLPLGSLPPLPLAPVHYVGGAFDFLPSARIEPALALPPLAPQPSFDAAFSMPSTPPECTAGAPSMLATPSLPTFDACEFLDASLALFQSASQPPSPILLLPSLPNLDAHSQQQAPPPPPPQFSFDLKDFTSVQRKLETVPEDDYDESLFSSGESAIGSSSATDVMSEAGWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCN7</accession>
    <name>A0A2S5BCN7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCN7"/>
    <dbReference type="STRING" id="741276.A0A2S5BCN7"/>
    <dbReference type="OrthoDB" id="2526373at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="756" mass="81534" checksum="BE98278338322E8C" modified="2018-07-18" version="1">MQGLLAAAAPTAAAAPLPFATLSSSNLARHTSSNPPAPRKTVQHYLATVEPIHASNAYELGPPPQGEFDHVKTPPRAVEAKRKRRLQDWDDDRGESWIRRPEIRARLTGSDRAADGEALVLIRADSPQSHRDRDRTHAPRPSGELSQRPRKPLVVTAMKGRSSTPASRGAKNKQATGAISAPLSRSPSRDDADAGSDKSSFILPRAIQPVDTSKGPRDRKGKRTEKDNKAMKRKEGKPGRREAERPTEAAEQAELDDLEERLRGRRERRRQNALIRKDRSLPAAAVGVAAAARVKKAAKQTKRARAESDADSDASSSASDEQAGRKPAKRASKEDRSRERVGKLDRPSNVGAHRLTVKPVQLGIFSKGKASARAKVGAARSGAFDEAAFLAGSMEEQAEELPSWLTFPAVNKPSRGKTYGNRPAKRRAEPVSRVFEDSSSDSSSSEEERVPVRPAEVPVKGIAAAKRRREKSDQVPAFWLDIPTPRSRPNSLIATPPAVKGAEVDRREEAEQQSTQASALSAASLARRKAAQALTTARRAGAVTVKDTAVVEERDRQLDNVHGEGFANLATGGDASAAFEPGVDLELHSPSSAHTSSIGRLIAEIASPESDKQESRHDMAQPEEALAMSSFDEVLDFAPSVASVPLEPAHPGEDEALLTAPAPAFRGGVSPVYQAAFATDDLVLDDLAGELAEPRDFRDASPTHEAPCGLELFDVPSSLPSVTDPVAFVDHPDLRRGSDEVAFREAMLRQWPKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCQ6</accession>
    <name>A0A2S5BCQ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCQ6"/>
    <dbReference type="STRING" id="741276.A0A2S5BCQ6"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="540" mass="59509" checksum="5F53CF5E71BBF3C1" modified="2018-07-18" version="1">MASNVPWRPLGRLVAQQSRTLASIPRASRPLAAEIARPYSTRSPPCTCTDSLAPSLLQSRPAPSRTTAAFVRGMATRRAAFLPTPSHSRSAPPSAIRLLRDAVVRSQCRLQSTAAVDPNAALLDSAASTTFPDPPEVPLTTPLVSKYLFLIAGLVFAIVVVGGMTRLTESGLSITEWNVVKGVKLPMTNEEWQVEFDKYKDTPEWKINNQHITMDEFKTIYKWEWAHRILGRVIGLTFLAPIPYFAYTRQLSRGAFFALFGIASLIGGQGALGWYMVKSGLDEQSVKDLGGVPRVSQYRLAAHLGMAFLVYASCLRFGLGVGRDWKLARKAKGLAGWKTVEETIRGLQGKTVGRTRAIATVVTGLVFTTALSGAFVAGLDAGLIYNEWPLMGGKLHPPSYELNKDFYCRKEDKSDRWRNIFENPTTVQFDHRMLAYTTFASIVTLFLYARRPHVRAKLPPTTYRLIKGTMHMSLLQVALGISTLLYLVPIHLAATHQAGSLVLLSLALATGASLRRPSSRVVKEAMRMAQLRQKAAQIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCU0</accession>
    <name>A0A2S5BCU0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2348</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCU0"/>
    <dbReference type="STRING" id="741276.A0A2S5BCU0"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="168" mass="18383" checksum="AE0436902CD80AA3" modified="2018-07-18" version="1">MAASVEWTRISSKLGLGKQALNELSAFRTRAATARAANAAVKEQKTSVDFEHYRQVLKNKDVVAEGEKLFKSFKAVDYDVQAQLKAIAAFEAKAVSSAKEAASKVESELGNLNSTLKNIEEARPFEQLTLDDVAKARPEITKTVENMVSKGKWTVPGYTEKFGNLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD04</accession>
    <name>A0A2S5BD04_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD04"/>
    <dbReference type="STRING" id="741276.A0A2S5BD04"/>
    <dbReference type="OrthoDB" id="9997422at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="800"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="894" mass="97342" checksum="9F3D273314F59305" modified="2018-07-18" version="1">MASQQGPPPVTNPDALSETRPPPPKPPLRRPSGSVTASVAAAVGKPSPFPSLDLMLDHRSTVSHALAQSVRVARQKERTHEGGKAEDATAQTVEWAPGERRVKAGLSPGQAARKVLSPPSTMKRAYRRFFIKHDLKHRLEWEPQELEEAAARGNFPYRPSDLFLKMYSDVLTCLTRDPLAGNVSPALIGASGTIPLSIISTIPDIMQHYKDCIVLAEKEVFLVTNYWQPSDSVNTVASGLRELNKRVAERKGPKIVVKIMWDRGAIPQLWHNHVPVSPKTYAPLGVPEPSEVPNLSIQVVNFHRPLLGTFHQKALVVDRKVALLNSNNIQDRPNLEMMVHLEGAIVDSLYDNMLISFDEPLKPSLPCLVEPSPSTHPHLFPFTFADANPYLADIDVAKAAKAARILLKRQDSQAEKGEQTQSLSPPEWWRRDSASPSPWPFGALSHHHPNHLHTTPRIARTETDEHEGGRFAALVMQLVEKAREEKARLALGLGSARQSTDGPNAGSTYPPVAANGLASHSPSGPSEGPRSSVADSGVELTSKYSTDDCRGTTNGQPVSPVAEEASPGGGSPGKPDEPSPPGFDEPDAPDPTGATIPTAPPAGVDGQSDPSPSRARAETNGKGTSSSARLAALSKALNAGAISKVDAAIEDEELIRDFKPHMLHKAHEPFPIALVNRRPHGSPGHMDIRCPQAAAWLSALRYAQKNVFIQTPTLNAAPIVRGIIAACSKGGPQRTGIEVTLFLGLGFNDKGESIPFQGGTNEQVVFRLYDKLRKLRKEKNLHVYWYTGKDQIRPLNAVHKSRNCHIKFMSVDGQCAIVGNGNLDSQSFWHSQEANVLIDNPQIVADWMDQLRTNQSTHKYGRVDTDGIWRDPTTGEELEKPKSISCFSAMRAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD57</accession>
    <name>A0A2S5BD57_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="741276.A0A2S5BD57"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPX_dom"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="651"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
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            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="82133" checksum="EE85A3A0BBE47F52" modified="2018-07-18" version="1">MKYGKQYLESLESVPEEWRQQAIEYRKLKKVINRVANELKELGLTSEVLRDLLQTHKVASPPAPAPAQLHGASHLHWSSGAEPSSDAGNGDDKTGSVQAGVQEALDDAANSMAEASEADVDEIQGLSAKARGKQKAVRKRRVHATYELRGTATQPEPCIHLVFSSCSSTSASESDVRSPSREDSEDPAGSPANFLFKRHARRRSTASAETTRERIVEIASSDGEGDSDAARTGTGATASVSTSPPLRPARKDTPDTTPEGSSSGQADNLDATESTGSIAEDVDDDIEFEGAGPQANQLLRRMYGVGRRWSEDEDGAAIVELDEGGEEAERPDLEGHPDAGGAGDAAAHPASRQIRRTLSEETLKSKDAFDMSAIGKATAAAQAYRTAASHEKARLAEEQGDEADDEEDGRQKARRPERKRRARQHRREVYIPLTSDTEFLTLLASALNSLATLQLAQKRQFSEAVATLAKEVSAVSSPSRPKSDLYIWREIFSLWIEADIFESSRERDRGERSIEDVEKHLEWFVDQVAKRKLAKRMKHKESRVALEKFIALNVELLDLKKFQVANEEAARKILKKHDKRTALTASLGFPQLIGNDTTNGISTELMSRAADGGKSKPVLTLPGFPSLPHILLSTFTSTLLPVIPTIEDYECLICGDIAFKPIRLNCGHRFCVRCLVKMQKRGQDNCPQCRSAVVLRADASNLDLEMSKYLNEWFPREVKAKEKSNQKESAREELAEMGLKDHKCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDH6</accession>
    <name>A0A2S5BDH6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDH6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="207" mass="23153" checksum="12D4D702161F9D9A" modified="2018-07-18" version="1">MPPHLPLGHGKRPVSPGGQLANPEADEDDIDAEGESDPEYHQHVSANLSDAEGSDVDGVYESDPEYPGPPLGHHADTEHPSRRGGRAEPYTPRPRKQRMSETTYREEVEAIAKAARDKTTSLRDHVHEDVNILYPNESQKHLDHRLQQIAAWVTAMLGPDALGRLASASREILEKNFQFLAEEIEAMSTAMFRLPTVRMFFTLDVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDI7</accession>
    <name>A0A2S5BDI7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDI7"/>
    <dbReference type="STRING" id="741276.A0A2S5BDI7"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF40">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="183"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="434" mass="45376" checksum="C6E1AB7B75B279A3" modified="2018-07-18" version="1">MSSGAPPPPPRRSAALNASSSGTTTPKNGTSSGGWKGKASAWGNKAFDKAIKLSDKVAPYANNLTEKVGGERWWPSSDDFPLEVAKCTRILRAFTVDGVAQTVEEKDETGVKRKRKAFRKIPAEVLRAAKGIVVYTSMRSGIAPLGGSGGTGLICARLSDGSWSAPSCVAPAHDTGHPSGNFAGGLLLGLDIFDAILLIMTDESLQAFMTHKVSLGGELAVAAGTYGAGALGEIGIEKTPIISYQRSRGFYAGVEAVAQAYLTRFDENERVYSLMGVTQRDILTGHVKPTSDAHPFLAALREAETGFAQRALGAENQYEQAFESNTVETGADPLTHEAEEHAALVAQVTEPDEKRANTAVPSAGATSSALAPLPPPPRRNVVPPPPPSYDAALIPDTPAPAPLNTVPVTVHAVEPESVTATGSTPAVTMTEDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDM4</accession>
    <name>A0A2S5BDM4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDM4"/>
    <dbReference type="STRING" id="741276.A0A2S5BDM4"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="354" mass="38539" checksum="29C329DD0D9BD591" modified="2018-07-18" version="1">MSNKMRAVLIKGGKSDSAQDLYLGEADRPTLKEGDGRIIVKIKAFGLNRMDIMQRRGVYPLPPGASEILGVEFSGTVEEAGSSDFKKGDPVFGLATGGAYAEYISVPAGMCTRKPDHVSWEQAAAVPENWLTAWQALFLIAEMKAGSKVLIHAGASGVGLAAIQLAKAFDAQVFLFAGNLCFALTTGFLQRSAGTDEKIKFVEQHGAKGINYKTQNFAEEVAKLTDKTGVDIVIDFIGADYMEKNLASLGRDGRMVMLGLMGGAKTEGPFDISQILYKRLRIEGTTLRSRSLDYQSNLLQDFSKKALDKVFARCKGDEGLDLVIHKTFDWNEIAQAHEEMEQAKNIGKIIITIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDP4</accession>
    <name>A0A2S5BDP4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDP4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="176" mass="18962" checksum="DD8E815D46177D87" modified="2018-07-18" version="1">MELKRKRDQRRRLGKGKGRARTETLKQPEAQEAMARAYGGAVASGSGIEHGRKHSDGPRNANEPPGRVDAQGAGFGEDQPAYNPHWFDGESHDQQDLGGCEQGFFGMDWEDAPQRPIDAPRSSFSAEPVSDQFHQLEQINGGPVPKHSQKLGDGRGSGPEAAPVTAGPPDMPSANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDQ3</accession>
    <name>A0A2S5BDQ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDQ3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53224" checksum="D6BC5331172F9222" modified="2018-07-18" version="1">MPRPTRPSAPPLTSAQSSLIGNGTATSLLRLPDELLVSIAQQVHAAYMVDERRVPPPRYFLICRRLYPIFRTAWLHTIDLTGPHDLNWLEPRRKDQLARLALAKDQSITLRNHVVQLAVDFEPFEDILHLISVSCFSNLRSLSLARHDPADHSDNEDEAWKEYDLNSDTSKLLGHVALLLPNLHGLVSLDLRGLCLSDESGFTGPIELPPNLRHLAADENVFNARLCHATAALKLPEFTFECSRRNDQALPWESLKTLVFVHEDERMQILLVALGHSYNSALPRSAAALPLRSLTIRGNTRLNDLAALASESHLLNYIETLTITSFCYGYDKAPSLRRLQYLTLCDRETHQAISAHSFESLLDFLYYSKLRTLKYCGSLEAVFELCEKLPAPDGGTGMSNSTESEALPDSCEMCGLCRESSPFSRLLDFLTDATNVTTFCYRSSDKSPYESRYTRQHWVDEFECERWKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDR3</accession>
    <name>A0A2S5BDR3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-repressible protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDR3"/>
    <dbReference type="OrthoDB" id="10039103at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10035" checksum="F52A1977D2C0F700" modified="2018-07-18" version="1">MASSTATSTTESIANTVSDAVNFEFLSFHSAPSRHVSETVQQYTAGASKEANKDAAKDSNNSLGERASAGIDALGDKAKESKHDAKASGYRESAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDZ1</accession>
    <name>A0A2S5BDZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDZ1"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="252" mass="27439" checksum="606228FEC734ED37" modified="2018-07-18" version="1">MSTFTYLITGASRSLGLGYARQLLESGEHVRVVAGARNPDSAEDLRKLQKKVGEDRLYILKLDVTDAAQVTESVKELESSGFLRDGALDCLINNAGVAQSTGKLPSDIVPDEVLDHLQTNLFGVMNVTSSYLPLLKKGKGKQIFGVSSTCGSIGGPFGENSMATAYCISKVALNMYSRKLSRELEKDGFTVVVFHPGYVKTDMNDGKGDLTTEEAVRLAQVSSAPPTDNIFLKLGKDENGSFWRYDGERMPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE16</accession>
    <name>A0A2S5BE16_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE16"/>
    <dbReference type="STRING" id="741276.A0A2S5BE16"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="93"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="245"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="565" mass="61569" checksum="345B320959BF69FD" modified="2018-07-18" version="1">MPNANLDESSWQVRAADAYAETQAKIPAAWRIDERLLAPAWIDATEDFEKVEKRVDHVLEQSGILSQAELDLVHTDVTTLVAKLQSGQLTAVETVTAFCKSAAIAQQLYRCCTELFFDRALARARKLDEDRLETGKTSGPLHGLPVSLKDQYELKGVRTTIGLTSMLDHVGKHDAAVVQALESEGAVIFVKSNVPMSLMSADSVNNVWGRCQNPNDRTRTAGGSSGGEAVLSAAFASPVGIGSDIAGSCRIPSAMCGTYGFKPSFGRIPMLGGVGCGTGAEFVLPVLGPMARSVAGLELLMQSIAATEPWNVDPTCVPMPWTPVHFDRPLRIGIMYDNGMVAPHPPISRMLKETAAKLQDAGHEVIEWNVGDMHDRAHMLAHAFFRQDGGATLSSALKGEPILPNVDTGCPGSELNADEMRGKHWEAFGLRVEYRQRWNALKLDAVICPITSHAAVRHNEFNDVTYSLPWNLLQYCAAAMPVGQVEERDLALDASYASEPARVYLEGKKGLKPSRGEAENRAIWLDEEERRSMVGLPLSLQVVTPNYTDERCLAVVRLIDELVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE40</accession>
    <name>A0A2S5BE40_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE40"/>
    <dbReference type="STRING" id="741276.A0A2S5BE40"/>
    <dbReference type="OrthoDB" id="2537677at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="260" mass="30694" checksum="1505EB9CF8E46DF8" modified="2018-07-18" version="1">MKRLPRALHSPLHRVPVLWSLYRPLLRSTNDYSRLQLPVEHAQALTSYIRLRFKQGRHLRGLDKVRKQLIEAEQLLCQFDAATESDLQADRIRKLAAHLFTRESLRPLRPAPPVADRTIRKPRVSPSIMHATHFYHPIPRLRPQPIEISMTIFNRRRTSQRRFDKLEQANEYIRLAQSEEAFEVDVARQVRGGKKPPPTAQKMGDEWRAWRRDARAREMREVARSKLRIPNDLRDKSREANRRREQLRAEAAAGRRQPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEK8</accession>
    <name>A0A2S5BEK8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEK8"/>
    <dbReference type="STRING" id="741276.A0A2S5BEK8"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="254" mass="28540" checksum="8C4D69947A9EF843" modified="2018-07-18" version="1">MTDDALPEHAYYCFEVIRATLRRTRAPPAPFDGDQAYPLFVTWNIRSRSGGEPRLRGCIGNFGALRLADGLAEYAKTSAFEDSRFDPITAKEIQRLECGVSLLTEFELCADWRDWELGVHGIYVEFVNPALNLPPQDEGSNGTSDRAGADSPPNGSTSYRSLNELPKLRVRVSRSQNPRGLATTLHATFLPEVAPAQGWSKQDAVDAAMRKAGYRGTVTDEMRRNARVSRYQSRKVKRSYDEWQAWRTDQGYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEP6</accession>
    <name>A0A2S5BEP6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Tricalbin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_1626</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BEP6"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="274"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="470"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="613"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="735"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1110"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="926"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1511"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1511"/>
            <end position="1534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY75256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1558" mass="167956" checksum="4C56BE4AE182F31B" modified="2018-07-18" version="1">MASAPLEPQVGVQPTGATAPISELQEKVELAAAQVKGAEVHSFDPDATPAEKAAATLKAAQEKLAPVDLSNAPSLRGRELRTFKEDGGRAVATDIGTTPAEVPVTTGARDAEKATLQEEKKADAGVPPNEEERAKQIARDEGRLNADGSENPPGALPVKEAEKNKPREIPSWFAIGWTSRDRTLFLSPAEAEEHSILADFVQDTYYGQWYHNAGIIVFAVLASHFVTLFGGGYGWLIVVLAVCATYYETSIKRVRRNARDDLAREVAKKGLKTDVESAAWINSFMQRFWLIYEPVLSATIVASVDQVLQVSTPAFLDSLRMTTFTLGTKPPHIDHVKTSPDTEDDVVIMEWKVSFTPNDLSDMTHHQAARKVNPKIVLEVRLGKGFASVGKDIVVEDISFAGTMRIKLKLINNFPHVQTVDLSFMQPPTFDFVLKPVGFDLSLIPGLQPFIQNQVHANLGPMMYDPNTFTLDLAQMLSGAPADTAVGVLAITIHNGRGLKGTKLGGGSPDPYISFNISGRAELARTATKHSTTTPRWEETKYILLNSLTETLNMAIMDFNDRRNDSAMGTVTFDLKTLAEDGEQTGLQSDVIHNGQPRGRINFDVNYYPVLKAKKASDGTLEPLPETTSGVVRIVVHQAKELDPRGMQINPFFRLLLNGKAVHRSQTLKRSPNPIWERPHEMLVTAKSSAVIGLQVLDDNTLRPDAALGSLSVRLTDILEANANGNDWFPLSNARSGKVRITAEWKPVLMAGAVNGAAAYTPPIGVIRLDLRRSRDLKNVEALTGGKSDPYVRVLRRGIVIARSIVHDNDLDPIYDEIVYLPVHSPKDTFVLEVMDYQHNGRDRSLGVADFSVAGLIAEGPDKHTKPWTGTGKISKTERLKSDQHKTVKGDIEYEAEFFPTLPLRDVSFAPADQVKTAAKSIAESTEASTLSSDSVHEGSAGDVTPRTASFVSVPNTPQTVGETALLAAAAASVNNGSVLPGIAMSREELVKQQTGLLVFQVISGQLAKKGARLELLFDDGYWPAFTTEHSRSTHNTWDEIGEALIRELDYSTVTLQLNTAEKDTREDVIAKVQVDMNQFLESSLDKPYTFTLMPTDGFGARSTVTIMSKYIPVSMQLLKRESITDTGMLRIDLLDGKGLPSADRNGKSDPYCVFSVDGERVHKSEVCKKTLAPVWNEKFETHIYSRERSELLLEVFDWDRVGTSDKLGRAIVDIDNGIEPFEAVEKTVSLARFDDTTKSAGEIRIRLVFTPQFMHRTRKATSTFSAGRIGTSLGGGVANVGGGVVHAGEFVGKTGVGAVSTVGKAGFHGVSSVGKGVFGVGRRLTGQQSRRTSYAPNDAVDFAAVPTGSGVSGTTPPGDENGYEVLAAAAGSHHGAAGFGATDTGTAGNLTVTLGELKSVGDQGEKKAILVKLNGGKTLFESHSHKDEPAVLGETFSVNTPAEGPADLTLQAVHKKAIGSDKVLASATFSVWQYVSPSAPSASVTIPLAGGYAGQLEVSLAWTPAPASLSQSGSFSTLDPDQRSIAGSTTGGSPSIKRSRFSSARFSRHKESSPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEY7</accession>
    <name>A0A2S5BEY7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEY7"/>
    <dbReference type="STRING" id="741276.A0A2S5BEY7"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015521878" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="184"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="568" mass="63336" checksum="CA33FF12999ED720" modified="2018-07-18" version="1">MRWAVHLISTSLLTARAAALWPKPQRWERGSGFVRLAEGFRITSSLNQEPPDDLVNAIERTLKRIEHDWHQPLQVGRAEPDRLSVEAAPVLGTLQISLVDEAEVHSIAFETTRPYAQQNEAYKLTVSQDGVAELRANTTLGLLRGLETFSQLVFTLPESAEGRRDHIFYLRKVPMSIEDWPALPHRGFMLDTARNFYPVDAIDRNLQAMSYAKLNVFHWHVVDSQAWPLESATFPDLARYGAYSQDETYSASDVRHVVRYAASLGISVMLELDMPGHTASIASSFSDYIACHNQRPWSAYAAEPPAGQIKLGHSDAREFAKRLMHEAALMSSSPLLSSGGDEVNQRCYLEDPDTSAALEARNVSLDDLLGEFVEGVHSAIRKQGKTPVVWEEMVLNHELGLDADVVVMVWISSANVRAVADKGHTIVHAASDYFYLDCGAGAWLGNTPNGRSWCDPFKSWQKAYSFDPYHNLTKAQHRLVLGGETLLWSEQAGPENLDSIAWPRAAAAAEVFWTGGSLAEGRRRLQEALPRLHDWRYRAVARGIQAIPLQPHWCALRPGACDADEDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF18</accession>
    <name>A0A2S5BF18_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BF18"/>
    <dbReference type="OrthoDB" id="2529847at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1528"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1614"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1549"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1813" mass="187436" checksum="E673603EC41D3684" modified="2018-07-18" version="1">MPSAPPAALDPVPRTDSLELQRHYVQQSAAATLNGQQPRSAEPQYLGGDGGNSGAGGRRRSSENAQQQQEPHSTQLRRLSSGDPDPIRHPFVAYDPTRLKQPRGQRKASTPDSSGRLKVGSNSSAGMPANSAAPPLASAVPLAQASSDQYGSRPGSRPSSSSGGGQPSPQLLHSSTSSSGMVQPASTSEGTYQIARIHPVSSNAPTSSNGTGQSAYHMAVSGTAVPNSQSTLRQSTWSTAVPPSTNATVATTTTTVPNTPAAVQDPKDFTLEQMCESRTYIVAKAQALGQQGGFLLVTALFDSLLRRFETDKLPTSDEALLRFAPDMMPVAGTRPKDFLMIWRMWVDWTEHELGIPTIPLVAPLIALFLLDKIVSMDDRTRLVQILDLYRQAAFDVMVTLGGKPPNGLLPQWKSDQWHEWYAMLQTGQTSLFDWRSIREACGMGLTARATPAAPPQSSLMSVPAPPTVPMIAGPGFAPTIAAPPLSAPPSGAPYVPHYSPPPPMAAPPLAPPPPGAQYVPPPIQASFSVPAPPPPSPADAWPYHVPPQPPTYTPYHPGIAPTLASFHHPMHEVRPPSAHVPQRSASFSQGQQTMFPTTYGEATAFWQSGPVSATASGPAIPLRQPGHPVGVKSLPVSPQVSPQAQFARPLSSGSGLGRGSSSPTNEQQPPQRPPSPPATSTMLSGFQAKPSSSATQQRVGSVSPAQMALGTERPRVPFATGFRGSVSAAAAAPRSAPPSTGSFAEALHAEALAAAGGAPAGSLSSSTTEHTSVSASRQPAAAQSSAAPLPAPRFAPITHDPPASGSTAAMDPPQTLGKRKRTVQETVQAWKRLAHEIPLNNVATPAATTTTPAVRSPGSLATQSGQESRAPVQQTVAATHRRDSAPPVSSSGLVASQTKPTVLDVRERRVSGSQPPASETSQPRRRKTSSLKPPAPELKGISLPGDENMTDEGYDKVLDETLEAIRGFEQARAQFSVAWEATPARAGEPMPGIAQIRHRAPRDVVSASPWRDGKKQVCPSKSASLDLEATFGDFLPLPACSSTSPAPNVVQPIVRFGDPIYAWRPFPTVGANNQPPAIDLTYTAKPCPATGPLQDIIFLTPRLFLPWPEPLAPITPAVATSSHSHLKSLEAISRKRIDAEILEGRLPADDGEAYAEAVRRHLFHLVYGAIKDGKMNGLGNLKAPRLAKATRKKVAQVMAEGGVSAPTPAERIDAEAKAASAAAQTPGASTLAQSTSEEKSEGDAKFHPTRGSPKTLSAKLPLESSAASNDKEKTAQMTAIASLPNSPAVDKLANFKADLNSVSGTPIRAVSHTATSSAPPTTAPSSAAATPDGSPAPSKARRPSLAGVGSSASSPAVPGVASGSRPRAKSIGGRRVSTGPGVHPLAQIYAVAPNGLRQQLRELSADVRGVPSDSAAAVLAAAAKKIQPAARRALSMTASPRLASSKELAHPSPPLVPIPLAGEAGSGEVVPGQVDKGKGKQKQGSVEPPVPKKGSALGVLLDEEVVPDSAACGSPVGGVSQVSDATGKLVPAAPSRPGNARDAIVVPDSAAPGSPVGSAAKSALSTAAPSRLAGKDGMVTTEVDSPDIPLASLAKGKRFAPVPHRSLLATGAQSAVADEVDSPDVPLASLAKEKQRVVESAKDTEMADAAPVPAPSPAPSASSSFASAFSSVARAAGGALASAARAFLPGSTAPAAIELEAEDEEEPSSPVRTKATIPPTVPISIGSPEAAQPPPTAEETQVAVPNVVKALTSPIAGTSKTAVPAHPLDTSALPPLYLPVEPLRPCAVREIARSKAHWLKASEPYRPFGPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF31</accession>
    <name>A0A2S5BF31_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF31"/>
    <dbReference type="OrthoDB" id="2527924at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="416" mass="43827" checksum="C60C32AFA24EB8D1" modified="2018-07-18" version="1">MKDAWSYGTTVKPPDASTASLALRATAPVPATADTVLASDQVDLRTQIYADGAELGARSLLGSVVVEEIKSWLIKHQTALAIDRVGLPTARDGVLTIPLHAYTHSSRADALAQPSFTAVAAGGIRPKPASLAAMSLTLRFLSPSREHAERQDTPIDDEEYAARGADAPAAGDGGPAALAALLAATASDSTDLHFSLTPLLETALTKLGKKLVVAFPLCFSSRWMTRLANDHATRRSLASSLCSILFAVDSGDAAEDSGHGHHLQDDKVAREASLLKLTLQMRFGAGAGKDSGDALQGSSDPNANADDGRLDAILARALLHIGQAYSTPDSWQGPAQAHGLADTRASTSFQAPAANGNRQDRQTGESLRSSGSSKSRREQRLAQDAEDDTLTCAQLPPVFRSARFDVDDDMELDLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF91</accession>
    <name>A0A2S5BF91_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1508</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75437.1"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="9">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="372" mass="38125" checksum="8C475B6B083D3BBC" modified="2018-07-18" version="1">MDSSAMRLVKRTLSVTNSSNQHAVAYKVKTTAPKQYCVRPNSGRIEPGETVEVHVLLQPMKEDPAPGQKCRDKFLVQSVAITPERESVPLADLWKQLEDDDKARSEDGPAKIHEQKIRCAYLPAAESDVAHSAIPEEQQTAHDGDASRMTSADASFVSTSGTSRSADSPIAASLSTSTPPPAATLASTSSRDGAEKPTTGAAAPISPVYATHNLALGAAVGAPVAASSKAPGSDAAASSSSSASPNVVPAIATSYHSTPTSAVAAAPATSSSTERSTGSSGPSDAELSRLRSELDAARAEISRLKMQLEGAETTNATLRSRGAGAGGSVISSDKGAGVTSQAVVDLKGQEGVPVQVVAGIAFGVFVVTWLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFC8</accession>
    <name>A0A2S5BFC8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFC8"/>
    <dbReference type="OrthoDB" id="2529235at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="69013" checksum="2591B46A479851B0" modified="2018-07-18" version="1">MQSPLAAAFDYPVRQDSLSSRTPRRNNAPAVKQHAPSTSTSSSASSSSSSAGPIHAYLYSDDEGHHTRSSSLATDFTTASEHSRNGSTSFSPRKDAFAFSPNAQTTQALRYEARPDSSLVRLRERTRYRSSASFHPTNAYALQGAFGSLSLAEHHDQLDALLTQADGAHSASLSSPTSESETAHLELLAALAATSTTLDTCFCGQEPEEDSIYCSRACAQADALNALCGGGSGGASNSSGAEDAFEPFSTATGGGSSAMRRSSSNYSHQSGSSAFSGSESHYRRIEREETRKATERERAQRRLKSSTRSRRKPAPVSPEDERAEAVAKAARHLFGDGGEDDSSAPSSRRSSRPSLRQLALAQDRGSVLAPRISRSSSSSSPRVTSYSSSVSSHTPASIYSPVSPRESTSSSLASPSDPDQYASASPCIVEPPYSPSPERAPVNELPRGLGFEHPIRPCTPSPRIARPASADESQGGMLVSDIYASYLAATPRGDEPQQRQPHGLLCTPTGLGLGLGPTGGDSLSATPRAAIRGEVPEDEEEDSPTQRGAGGLSDVGLRMLELCASDDEGDEDDVRGRGWAHDESRDSFDARDNGGACWTGGQALQRRMADRSASSSSRRSSTSRSTMDEDRRGYGHTRGKLSFDDVVGILGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFM7</accession>
    <name>A0A2S5BFM7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_1196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BFM7"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="224"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1625"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1740"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1625"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1794"/>
            <end position="1820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY75574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1826" mass="194430" checksum="656327CADD979AF9" modified="2018-07-18" version="1">MSRAAPPPPPPSSSSHSRRSTAAKSAGLANQHQPAGITAQETSHAYRSSPIDHILAEQGLERYHLEPPTWRAPWIVKSSDGGIPTSSKANETVASVGLGPNKSLIRLAGAPAPVAGPGGAAPAYGTVPLHAAASADAATGNEATCSAWPVFYPPHDGMDEDRLTEQVVKQGFAAKSLVSAETFSAHQHIYDKLKTGDILGNLSRLVSAVREKAESQLPTYGPSTFRLPSRITLTDSKREAWFSDLASPSVPLSKLSRSVPHGYKGEKGLDMLAHRRVEIDRAVWFVRAFGGVEIQSLAKSRPLATAIYLYTTEFTGVVCEFLRKQLGEVVLPGAVSNNPTSTPTSTHASPLGPPVSTTMANASRARSGSLSMQAKAAAASAAAAAAAAQSDSSKLGTPGLLDETKRKAWEEKYHYTIRLVSSLYRESLLDRLQFLHFIVSLLESRPALAPGDQLGQLSFAVSLIDGYLDDILESEPETARLVGGCMSRIQELEHTPTSSLRDVIRTNLASIVKTAFGKSPDAFASLLPSPVYSSLAFPLVDTEGLERVLTKPISGKHGEGAPDADTRLRSQFYAEIADLRARRQLLSATLQAQSDPSTAIEDLAADDRARLAAIEHLDAFEFPQRIQETHRNIFVTARPDLVLHWDIALPLLFTYATTTSRPCGPHRRYAAARLISLERERLQDGVKRVTRSSSQSRLTHVEDAFVRWVDGLDASIPRSSIRSLAEELFRIGVMNYGAYLQRMIARGETERDSNGEGGESIHLWILRTVPLESSLAGVKSRIAGGGKVVADRARRIEHALTCVKQAIDDLFSPEAPGKMASVQSSCAVLFEQLDEAIKDGAHWNITREMIPNALSSWLPSTEAALALPADLVAVAVAVFKKGEDWAALLQLLAALVQLQLSEDTVGLIVDVIESRLDIWAALDLLPDLSQALMARFVSIKKAEQPIPRRLLSLLVTFAGHDLLDAEAQMTLKQELQSMVVAASPTSARQSLPQLPIPLPEMQALLADSSPAATSQLASSLWHRYRGHPHWITALLDSSVLYIPQLGAAEPLIELITNLESRTPLGVFSAALAPWTSNMSVSQAETIFGGAYGEATAFLFAELGIAGVFDTPALLKDLVAPVRRTTLKSLLRATGTSCSTDTSLAILHNVQLVFAPVIAPASSPGDSVLPGAHRLPRRHRISARRAALTRCVNLPAIAEALAGLIVEQEVARRLGYDDVAEHTGAYFVRLASLPRLRALFARVPRALRDGMLDNEALNALPTVQQLRPNLLAGLLVVLKDGGAASPASLGSTEELDIFLSGLSIWRLNVSKVELVACLERLELDPTISAVERHAALHTLSGHFLERVCGGDGKSYLGEQVLVSVAFERLADAVSILTDDSAHDDSRERASTVVRTTSTLLDKFLQVGTAISRIASSVRFLESIRAALLASCRASASGARVPGANMHDPVQIARLAVLALRCLARSKEGEPTELLKDCLILLAFQAATLSKGSLQYSQQATLLLDACSAILYALPDIGPSVRAPTLSGLVNAAPPFAISLENLPDAVLDRLCRLFGPRHPTSSVRNPWELLDHADPAMTQAALARKAAISANSYYAPPSQLVNLGPIDLASFRARVSATIPAVTAADASSSVSTSSAHSGASTAGTQQHQQQQQRRFEKGRQTNFDFETPCTTLGVAARDHRRTLNVTRLVSSRLEAAAAASAQAALTAAAAAASKKSAAPSSAAKHASATPAVPVSATAPLAATSGRGAKRRNSQQQGSSGASEIVVIDSDEEATGAGNKAATSLAPPKAKKAKTASNGSSASGTSGKTASKTTAGKAPSKTTRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFY5</accession>
    <name>A0A2S5BFY5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFY5"/>
    <dbReference type="STRING" id="741276.A0A2S5BFY5"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="297" mass="30749" checksum="54B88B6392FDC666" modified="2018-07-18" version="1">MAVDGDEARGTVHSIAPFTCTFPVNADVFSASAFGDPDGSDTVQLSESAASVPFIAVSTTTSANNTTPIKSIRPIIVKRDASVKPPSYDSIFPPSPPLSASSASSSPAESFFSQCHSPTSISSSVYKYRTRLATPTKSHAAPALLSSPISSPASLSSVSPFDVAFNEAAFTAASSVVAPAPVLDQVFPAEAPVHAQPSEDVTVEGLAGSVVENATAATRTMYLVGATAALERELAVNLMDAAADEYACDSLVLALRKDTEGLGDLLHQLLYIGATVVSSFEETGVPKEDYILLGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG49</accession>
    <name>A0A2S5BG49_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_1155</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BG49"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="14">
        <location>
            <begin position="73"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="1078"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="489"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="886"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="969"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1312"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="491"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="969"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1312"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1337"/>
            <end position="1346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY75745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1366" mass="151117" checksum="CF9A329013B55D19" modified="2018-07-18" version="1">MEWSLDGQLAHWDEHQQLDGDFSFDRDDSLDPLELNQHLNGDEDPTAITQPTQFNPAASFLQCAEALNGSTWSKFLDTLTSSFSALIDLVRASDSNPSDHTAYRAYKDPLEIYAVLLRCAIQTGEKIAANQAQGGAAANDGAKKKPAAGKKKTAGAKRNAFVWVDQIPDLLAGMVKALRTLRTERIWQTTAERDSLISNCFLRPCNQLAESEAYLKVPEIKQGIFRVLCLAAKGHGQAFTDSLAALDVQMTIMQNLQYTEHLAEPMAELVTVFAKEFDNDLLGAKVLGEIADRQFNAQDTKGPRSFSRFLIRLAETSPRLVLKQIVLLQKHLDSESYPMRNAVLEVLGLLIRELSLTEPGALDMDDTKHVRLLESFFQLVFERLLDLNSYVRAKAAAVLLKTCDLPPKLPKLRLELTHLAVRSLYDKAATVRKNCLALLTRLVLTHPYGRLHGGELALEEWKDRLAKLEEELKVLDLPDEAEREARRLMEDLPEEEEEADDDTPDVDDDHDADEGEAEREGTDSSDEDEGEAARRKERAANKQKKEQKRAPRRSMLDLAAADQSVALAQVDSDTLQRLRLTKAYYVDAIAFIEALEAAMDTVTELLASSVKSEVLEAIEFCKVAKEYKLEASEQGIRRMLHLIWTKDEAPNTATGAAAAAHGDDGDDAKETKGVRSRLIECYSQLYFEPPETLSEKDQIAFVARNVIELTRDATLAELTSLEQLLAVMMAKGVVSDEVIAKLWQVYSTSKDIPRFQRRGAIIVLGMFAQPKPEVVADHVETLLKIGLGHFGRADLVLAKYTCIALGRVGGSVKKVKGSLSDIQVRLPMDSPVFARLAETIQAPSTSKEWFSMAEQAVNTVYTLGDQPDALCSDVLRQMTVRVFGPKATARKGGDEPGEADADASMADRSGAGAADHSEEEGAEAEAAAQTTTGTLGDAYELSQLIFVAGHCAIKQLVHLELVERDLKRRKAEDEKAKGGKKSGDDELDQVAGSVEDDIGDVIAATKEKELMFGPQSLLAVFGPMAATIVAQPKVYKNSMLQTAATLALSKFMCVSSEFCAEHLMLLFKVLETSKEPAVRSNIVIALGDIAVCFSTIMDENSDRLYAGLHDKDPTVKKNTLMVLTHLILNGMIKVKGQLGEMAKCLSDGDKRIKDLAHLFFEELATKEKAIYNNLPDIISHLSSGSNPVDEDTFQVSMKFIFKFVDKKKEAESIVEKLCQRFSGTDQPRQWRDIAFCMSLLPFNSDNAVKKLLEGLPFYQDKLHEETVYKRFGEILTKAGYGSTQTFSGPIRAPTNKLSRTESDLKEFEDALEAHRAKGAEDQEVERKVQKTRRRAPAAKAAAPPARRNARRARVQQSETPPSSPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG51</accession>
    <name>A0A2S5BG51_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Glycerol 2-dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="6">1.1.1.156</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.156" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG51"/>
    <dbReference type="STRING" id="741276.A0A2S5BG51"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047953">
        <property type="term" value="F:glycerol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="305" mass="34501" checksum="A468910D9948D43E" modified="2018-07-18" version="1">MPEYMDVPEIKLNYGGRAIPAVGLGTWQSKPGEVANAVTVALQNGYRHLDLAWIYGNETEVGQGIKDSGIPRHEIFITSKLWCTKHRHVEAAVRESLERIGTDYLDLYLVHWPVPLNPNGNDPKFPKKEDGSRDLDTEWTINHTWEQMEAVLEKGLVKAIGVSNFSEPVLDELLKTAKVVPAANQVELHPYLPQHELLEYLEKKGIVAEAYSPFGSTNSPLLTDQDIQKIADKHDVSVGTILISYQVNRNVVVLPKSVTEKRIIDNSKVVKLDSEDMETLNSLYKTKGKRFIKPDWGVDLKFEYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGP3</accession>
    <name>A0A2S5BGP3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGP3"/>
    <dbReference type="STRING" id="741276.A0A2S5BGP3"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="108"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="601" mass="64701" checksum="0ADE7AC1DA92642B" modified="2018-07-18" version="1">MTHGMHDPPASQTRSSAHAVAGTSDVELQAQVRSAPTASPIDAQALQEVTETGTTSTLDGNESIAGGPEREKEPPDLDLKPEAPPLDIEHVVVIDDPREWPRRRKATVLATIAFTAIGATLTGSIFFPALESLQHDLHANDNLVAATVSVFIAGQGIFPSIWASLSEVTGRKYCYLASLLIYIVGTIVCSQAHSMGVFIAMRVLQSLGSSAVLALGAGTLSDMYDTHERGEKLGIYYACPLLGPSIGPLLGGAVTASSSWRATFYFLLAYGVACWLLVLFLPDTFRRERSLAWRKARDRARQLAAEDRLKARCALPPPVAPKATSNFSPMDRVKTAVSMRTGRDFKVKIKFSDINPLSAVGGVVKQPTNLLVLIYSGFLFASQYCITYTASRTFAAAPYNYTPIKVGLVLLSFGTGNVVGSVGGGRYSDYILRKMKERNNGKGEPEMRIKSTYGAMLFLPPLFVAYAWTVQEQVSVAGPVVVLFFLGAAIMVIYSSTLAFIVDANPGRSSSAVACNSLFRGVLACAASQAAEPILNRVGGNGPFYSGWAMILLVGQLALVIVAIKGKKWRAAFGQQEERAEALRQERRQARLAKIGEGVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGP7</accession>
    <name>A0A2S5BGP7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGP7"/>
    <dbReference type="STRING" id="741276.A0A2S5BGP7"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="485" mass="52767" checksum="5FF9A333FF35FC62" modified="2018-07-18" version="1">MSNVQVQHLPASDRSTKPRKTMGKLAMVFCCGSALISDGYVNSAAGTVNLFLGKLYPKQYKANHHGTIFTGIAYLGVIAGQLGFGCIVDRFGRKSSMLAASCIMIIGSALCAGAYGAHGSIDGMLAALIVYRFITGVGNPSGSVACSENSETTGINTRWSHMWFTLATDLSIDLGFVLASFVPLVLVWIFGDKNLEPVWRLTFGLGAIPAALVLLWRLKMPHESERFRQSAIKRNVPYRLIVKRYWRPLLGCSLCWFIYDFITYPFGLFSSVIVDSITNSSTKLTTVLAWNLVINALYVPGSFIGAFTVDWLKPKRQLLIGLVLQGIIGFLMSGLYGSLTQHIAAFAVIYGIFLSLGEFGPGDCLGLLAAKCFPTAARGQMYATCAAVGKVGAYVGIWAFPALINDFPAGAKQTSGPFWVGSGLAFLSALVAWYFIPELKEDGMRDEDEAFRVYLAANGYDVSQMGHHEDIDDESVDEDKKEAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGR7</accession>
    <name>A0A2S5BGR7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BMF94_1041</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BGR7"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001170">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="22">
        <location>
            <begin position="282"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="23">
        <location>
            <begin position="899"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="23">
        <location>
            <begin position="1005"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="24">
        <location>
            <begin position="1077"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="580"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="POY75957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1351" mass="147335" checksum="5F44DF84765EBEF0" modified="2018-07-18" version="1">MPDVAGADAFLADLLDGLDDSAFSSPTASGSFRPKQPATTTPAQTHSQPRKRLKVAQSVTAKLASSPSFRVHPSPSPLGPGTSPAPSTLLAIPPTPQPFWNDPFARRKLSPAAVVRRDGQPADENKAAELDATPTRAKRSRRHDPLSPVKKGALPAQNHATGRGLDVPAPKRVEIEIDEPQEPKRKALAEKGRNVGAPLPVVTLQAPLSDTSYFDDDFPLDEALWDDAPNTAAAKTSDTAQAKPVTTPRCRQFTRCTVEAIKEESDEQKLRKILSVSSDAFDDTRIVVLEDDWFDMLVRVGDTVNVLGEDGSYDLTCLEPVVISRSSRKLLVLHPDILVSSTKAADSSHCTRKAVLQELIRTVGETTPSLIYGNMLHSLMQACMLENRWDDSFRFEKIQQIVKDSGGQLWSVNVSFAKAQEELAERSKEFEAFADRFMGVQPKPGAFLSDSYANEADRSRLAIAAAVAEEEDIWSPRTGLKGKIDVTVLATLASAASIDHPAPIPFEIKTGRTNAGMEHRAQTMLYTLLLEDRYDQVVQTGLLMYTQSNDVFAVKRRENELRGLMQARNRFASHLHDRMTLSSTSAHTASKEPESAFGGSRARTTVSPAMSEGEPALQEMILSSSAPPVSVPATQDQSLLPPPIDEIRACRRCYAGHACWVFRRAAGGVDDTPADEELAQIHENAVGHLDDSEAAFFARWERLISFEEQEVARYKKEIWTLHAEERESLGRCLANMVVAEESIAATVQADEVPASTTAKSIHRFTYRMTRHPTQVSEGPASLLGGSISVNDPVVISLEDPPVLAIARGFVLSSSLYEVVLGLDRTITHLPQLASHSDGSPVYRIDRDELAVGMGRLRDNLLQLFYADAHTRRRKLVVGLAEPRFDPRAAADAHQVMPSHLNPDQKAAVEKVLSAQDYALILGMPGTGKTTTTAEIIKALTRAGKSVLLTSYTHSAVDNILLKLVDGDGPSILRLGNHDKILPSLRSYALSPADYATSLDAIEDKLMTPQVVATTCLGINEPIFAKRRFDVCIVDEASQVTLPTCLGPLRFAERFVLVGDHYQLPPLVRNKAALEGGLDVSLFKRLSEAHPAAVVNLTRQYRMNADIMSLSNTLVYGDLLRSGDETIGRRLLTLPCAPTASVPADWIRDVMDPKRSVLFVDTDSLPARERRDGSLIDNPIEAELVQKIVAQLSKCGVPEEAIAVLTPYRQQVNLLTSQLAGHPAVEVLTADRSQGRDKDCIIISLVRSNTTKNAGDLLRDRRRINVCLTRAKCKLIIVGSRSTVSHAPVMAELLDLVIARGWLYSMPSGSFDVAASHTRPIVAGAAVAKTPRRGGGSLAMKRPLPSDILNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH35</accession>
    <name>A0A2S5BH35_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH35"/>
    <dbReference type="STRING" id="741276.A0A2S5BH35"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="36"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="224" mass="24586" checksum="C69F2A94481A16B9" modified="2018-07-18" version="1">MSAETASQIARLLPNGLGAKGDEDRSPVEYPNRTLHVLVAASGSVASIKLPLIVTELLSYTNVDVQVVASKSATHFFSAEAIEQQCKGRVRVWTDADEWASWRRIGDPVLHIELRRWADIVLVAPCSANTLAKISNGICDNIVTSFMRALPTFVPVYLFPAMNTHMYSHPLTAKQLKVVQDELGYHVRGPIGKTLACGDVGLGAMTEWSDIVQLVVDKYRLQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH39</accession>
    <name>A0A2S5BH39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH39"/>
    <dbReference type="OrthoDB" id="2224399at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="244" mass="25675" checksum="9C2B8CD4BC758864" modified="2018-07-18" version="1">MSSTTARASTTPEGISLNSFLGKPPFSPAHSTLLEKIRLASSSGTSSDDPVVKAYSDIVYLNYISLGFSLSFEPSGGYKPGRTTDLEEVRTEAENERLACVGVDVYNQEEGGGDDGDKTSNDAKARKRKGPGAEYSPFPLFPILLPAAAVGGSGTDAKPFPLVPSTIGKEVVSRYGEPARKGGGESGTSMGVWTEWTAEGIMLEWRSTGLGAWEKGGEAKWSVLSLFQGGKEAGEDPEDGKVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH82</accession>
    <name>A0A2S5BH82_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH82"/>
    <dbReference type="STRING" id="741276.A0A2S5BH82"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF2">
        <property type="entry name" value="SH3 DOMAIN SIGNALLING PROTEIN (AFU_ORTHOLOGUE AFUA_5G07670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="173"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="230" mass="23572" checksum="D7E81CFCB3DBC2EB" modified="2018-07-18" version="1">MDKFGSAKSAFSTAKGYAEKGRASITPMFDKMDKAVPIGSGGNRPRTGSSATSPGLAPPVGAPYSSSSSSPSSRPPPPPMRTGSAHGPPATPARNSTPSAAATGGVFTAMLTDEQEKLAFFQLLDEYFNSRPQFAGLFEGSPHAAAPAPAPAAARNHAPVAPAASRPVPAAPAGLGTATALYDFEGTQAEDLPFRTGDVISITEIVSDDWLKGSLHGRTGIFPTAYVQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHJ0</accession>
    <name>A0A2S5BHJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair and recombination protein RAD54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BHJ0"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000020">
        <property type="entry name" value="DNA repair and recombination protein RAD54B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="650"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="979"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="513"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1169"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1286" mass="140189" checksum="71ABE6D9C2C1EB8F" modified="2018-07-18" version="1">MAAAGPSKRAWDVQWRNFQARKNKTWEKDGVMLVEGLGVTVYAADGKLIGARNLTMPVSAEMEFSLSGKDVMVTDQTTLEAYYLVARSKGGLHAAHSASTATPSKPVPGYLSRGAAPALTDARSTTPSHGRQTASGPARTETPVDPASSNETPSMATTSWVQPHQKFQKPFKSPAMRPVAHDGGSPAARLGTASRAAVAGPSKLRERLVPEPQAESPKRAAIGSKGKGRAIESEDDEEMENSPPLAQPDGPPSHKKLRVELPKAAESPGPARLARRSAADAAFERAISRNNSVNSTGSKDSVRAPPLRTRSTPDRPGSTREANQPLFRRSESLSKRSPSSGALRVGQTSAGDEVLEGSGLCDDMELDAKIFDDDWGEESEEEKPQVSKQAAAFEEAAEIAASTLSESADRSSQPEKRKYSCNWRKKTTAKTANWAGDATLMLTGRQARLIDDESGKVLAQGGLPANVEVEADAQFTYCGITLQVLAEETGFKSSATVTLLAPEPNCPPVRPVQATSGTAFRPPAPAKATNPLARRVAARSASPAVEPAPPRREAARQSLPPAPTTNDSFKLPRLFDGSADSPAAARRRTGPLFDPTTEGALVMPRPTTAHQQEYNKHNAPIVDVVVDPKIADKLRAHQREGVTFLYECVMGMRSSGQGCILADDMGLGKTIQAITLVWTLLKQSPYQAGQNGEIKRAMIVCPATLVKNWKAEFRKWIGKDRIKVLAAEDKQHIHTFVYSKNYDVLIVGYEKVRDCVDELKAAQPPIGLVICDEGHRLKSEKTKTSQALQSLSCMRRVILSGTPIQNNLGEFFAMMDYVNPGILQDAAYFKKNFEVPIMAARQPDSSSKARKEGEEALETLMSIQNHFLLRRTNEVILEHLPPKHEYTVFVRPTVLQIDVYRTALSTSAIRTVLEGRDMKHGLALLQNLLKLATSPGLLWQQIKEKGVGDLDESVTNAFPADIDAADFALSSKLHVLGLMLKTLFTDGEEKIIVVSNFTTTLDLIEKHCKRHKYPYCRLDGKTPQQDRIAIVDKFNKGPRNHNFVFLLSSKSGGTGLNIIGASRLVQVDSDWNPSNDLQAMARIHREGQPRPCFIYRLLTSGTVDEVVYQRQLTKLALSGSIMSGDGGSSSKNKNAFTADELRNLFTLHDEVACQTHDLLGCRCHIGEPMPEDDDNDAGDASNSESSSEDEFASGFVQASQYQDQDAKRSLARSRRHLSVLKTWTHASARNVEHIEKLQDGLLKALIYEKLGEADETSISLPSETPDDLDLCHGQIAFVFEKKTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHR1</accession>
    <name>A0A2S5BHR1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHR1"/>
    <dbReference type="OrthoDB" id="10369793at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="136" mass="14131" checksum="C67529190277EE5E" modified="2018-07-18" version="1">MFSARSLARYAPRPAVRPQAVQQPHLISTSFAPIRSSTSAFSTSACAKSSGEGVGESKPIGGENPISARADGVKKAVKSVAEGAEGVAQQATGDEQSTFGREAKHPGPDPRNVHQQEQDKGRKAGLAHKGEQQGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHV9</accession>
    <name>A0A2S5BHV9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHV9"/>
    <dbReference type="STRING" id="741276.A0A2S5BHV9"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="474"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="76962" checksum="E6445922D5904B08" modified="2018-07-18" version="1">MTSTAPPAPTSTAADAADSKVSYVDVAIIGAGPAGCMALDVLSRYADQGLTVRCFDKRSAKLDNGQADGLNSRTLEIFENLGFIEKVQKEGSPMSEINFWNPDPATGRLTRTAKIPDTIPGLSRFQQTILHQTRVETHLLDDAKLHTKGRFSPERSMLPETLDLDEASANDPDAYPITLTVRHLSEEQSNPSAFKGETNGTRSGLFRSSLLSAAEEEKLYDTEGSAVVETVKAKYLVGCDGAHSWTRRQLGIRMIGDQTNRVWGVLDMVPLTNFPDIRMRCAVHSANSGSVMVIPQPEGLVRLYIQLPIQVKQGEYLDRSQITPESIMSTARKILHPYTLETDHIEWYTGYHIGQRMTESFGRANRIFLAGDACHTHSPKAGQGMNTSMQDTWNLCWKLASVLTGSAKPDLLRTYATEREVVAKTLIDFDTKFSKLFSGKPAAEADVEKDGVDLKEFKDVFATSHYFSAGMSISYGESSVASAQSKQQLAPKLVVGQRFFSAQVVSQASATADQLTTRTPFTGAWRVFVFPGDVSRTAEMERLRKLSAYLDSPESVVSKYTPSSRKRWDIIDVVTIHCAERTAVELYDFPQPSIFHPHKYDSVFVDGPSHYHGDGKAYEAYGISKEEGAIVVVRPDQYVALIAGLGDTDVLDAFFGEFMLPAPDGGYPASKVRTVAPPDWSQVAHQEIAKTLAVPEFDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIF1</accession>
    <name>A0A2S5BIF1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIF1"/>
    <dbReference type="STRING" id="741276.A0A2S5BIF1"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="84660" checksum="EC7B0724E55AFDB7" modified="2018-07-18" version="1">MKIFSQFAQLVYTLPAVDSSRVTESKSASLVSAQHTASSPASVAPLKGRFLHLTDLHPDPYYRWGTTEANACHYNKRKKYDHESDDGDGPRAAVKGEFAEEEEEDDGDGSDDELAEAVTASLSGPKATTKRGGSAQHKKKKKRRRHRERKAGYFGLPVSDCDSPLALINATFDWLGEHFRDQVDFVVWTGDNARHDIDSRLPRSLAEIQDLNRFLAERVRSVLGSKVPVVVSIANNDAWPHNQMAPGPNRITNFFADLWENEHFVPESSRKTVARGAYYSVEAIKGELLLVSLNTLYFFEKNAIVDGCPPVDDEFLSTSPTASRPHLDPSLHPTSPRAAELFNAYIASLRDSRSTVGAQAQSAAVDPGTEHLLWLEQQLVLSRAQGMQVWLTGHVPATRENWYPGCFASYAKLVLAYQDTIVGQLFGHMNVDFVSFISDADASPSSSRLHAGTHAHSPRLHGHTVHSSSGDVSTLDLLARMYSSLPARHKLHERDFAPVHVSPSVIPTYLPSVRVWEYNTTRSAKDESLRLTRAEQDRDDDLLARGRHVGWWRWLSRFFSGTSARDLRAEFEASQQRDPNRHSSRHSPWRTNTYLTPLAYTQYYIPEEELERANKAARRVLKSSNGTDPGSIEPPRWSVEYTTLSTSEAAYRLLEQQSPFAGADNQNRSPSSHDPLLIPGLLPPPLQNLLATPPSAAKFHRVRRMLNKLDLTPYNGVLSAREGLTVGAWIDMAKWVSKKGAKRWEGFRQRMGVGSGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIJ0</accession>
    <name>A0A2S5BIJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIJ0"/>
    <dbReference type="STRING" id="741276.A0A2S5BIJ0"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="8">
        <location>
            <begin position="595"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="725" mass="79121" checksum="A441727ED5BE21F8" modified="2018-07-18" version="1">MDPPDVPWTEPIASTSRAVFTLPYKADEQQDADQLGYAAGVEAYRAAWRATHDRIQDTLSTLHDASLDQIVAFVRAPESTDASLYTALSGRALLRTGLIIGASPGSSSLLYSSLVRQLSSVDSDTVDESAPTAVRPCLISRLASRDCSNIKNALRSLIGGFIGSSLDVDLEDEDDEEEDAFLAAPVSRKSEMIVPEDMHNLRAWYEHRYAKQDAQLAPKLVVLIEDLEAMDGKVLTQIIDTLSTNADSLPLTLLVGIATTADALWNLLARKTANQLDAASFFVDPGVGAFNALMRGLFIDWKAPLALSPRVYETLWRTFEDLHHSIDATISFLQQTYMTHYIASPAHALTPRAGLDDEDAAAAVKALQELQCYSAASQGSSAEPAVVLEEARAAYRAWHTARREAFAALTGMMEFWDKRKPLEGVLAAVLGEGEGGRNIHKTVDELCNLVLQASSAKLPTFVRAVIANLSALHADLDSELDLAPGDTLLRFAEAQLASLEPILAAPRPAGRSTLFNTNLVGAFSIPGMGTASKVDQGFSALAKETAEGLRTRLRHSFRPHTELALHELWFSDDRSAVKRVLPAPLPTTLRLLQKDDALTERNGDAENGAESAEPSDLSVAYRTFTETHPQGRLANLGEWWGAFELSAANEVEVNGAEGQGEGARKRRRRSDEDGDSEDEDENEDEDEGPERRKQARFLRVVGDLAHLGFIHPTTYKPEHVLKSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIL5</accession>
    <name>A0A2S5BIL5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIL5"/>
    <dbReference type="STRING" id="741276.A0A2S5BIL5"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="53"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="177" mass="19651" checksum="003CDF3C84591599" modified="2018-07-18" version="1">MLPRAIPFASPFTSTSRLTLDDDLGVPEPVPKPKPKGKAKTPPKYRPPKELPQLDEDDLEEQFVRGSGPGGQATNKTSNAVSLIHKPTGTRVFCHETRSRETNRKLARRTMREKLDELFSPPGESARDLKAQRERQKAAAKKRKARRKADAKSGATPSEDRGVEGEPGEGELMQDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIM7</accession>
    <name>A0A2S5BIM7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIM7"/>
    <dbReference type="OrthoDB" id="2527630at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="605" mass="63575" checksum="0500F5E6A5E5B68F" modified="2018-07-18" version="1">MHNMGGTSHQRIELRRRAAAGTTTSTTAATLTTTTTTTTSRAHARTTTTTTSERVRAATRTSSTTTTPAGTGFQPGVAASGSATSSAPNTPPAAASFTTSGTPSGTFAQQATWTPPSVLSHGAAIGAGTTASSGSTGGLSKPALYAVIGGASAGGILLFAVIGFCCWKRRKTRAEEDNLGWRDLDSGPAARPIRESQLVYNAPAEKPWAQQSFSSFASFDGKSPGIAPPPQTFVRSASDNFSSAPSHAGDSYLHDRQELFSSPRAMPRNYTNDSLHSFAPPPSVFAHQQDPRGSTAQSVNSVIDFASASPHRIMSSQQSHPPRQPHAYPPSHASMSSTAPPARNVSSIGREPITAQNYSSRPYSRTHRGYPSIDSAQHRTEDDEVEQRVFAVMMSGQPDADAPPATSGNKKDTIIGLTDAYGGVDGDEQPRADPPQRTSSRKDAAATSAPIHSAGPPIPTSRNDPFGPAEDADVGSSRVDSKPLRDLEALFERLPAAGLAPVHEEDGSSAAIMSRASGASTYAQRYTHDEGAFSLQAPPTRKGSLAPSVLPVVHAPSKQSYLDVSETPSRAGFDHDGFESLDAMNARKNADPSYRSATLSMYDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJA5</accession>
    <name>A0A2S5BJA5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJA5"/>
    <dbReference type="STRING" id="741276.A0A2S5BJA5"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="97"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="681" mass="74287" checksum="B4BF5FCD33EE2575" modified="2018-07-18" version="1">MPQIKQGSVEVGPPAKEGEGRIRRSFVSPDQLITSPAPGKVTVLAHILDHAKQEFADVQGLGWRDIIDIVKEDKQITKTVGGKEVTETKQWSYFHLSDYKWWTYQQFAEYVEHSASALRQAGMNPGTVFNIYASTGRHWQVMANACAQQTITFATAYDSLGEEGLRHSINEPSAGGIFTQASLLGTLASVLSETPSIKLIVYDGRAEDVPAGALDQLESRGAEGLQIYTFDEFVELGKQHPHERNLPQSDDVACIMYTSGSTGAPKGVQITNGNIVACIGAVQKLIGHIVCRGETYIAYLPLAHVMEFAVELCFMWVGARMGFGNVKTLTDASVRNCLGDIRALQPTIMVGVPAVWETIRKGIVSKVKAAGGVKSRLFDLGLAAKRFGGRGSFLGNVADSVVFKAVKENTGGKLKYAMSGGAPISRETQEFLTLALVMIIQGYGMTESTAMLCLLPPEMHQYGTVGVPVPSCEVKLVDVEEAGYRSTNNPPQGEIWIRGPSVTKGYYKRDDLTKEAWTEDGWFMTGDIAQWNKDGTLSVIDRKKNLVKLAGGEYIALERLESLYGSCEYVARIMVHADSSANKPMAVIFPHEANLKQLASSLGVSGGLSDLVHNKQVQEAVLKALNGVGKKSNLKPLETLQTVVMTDEEWTPQNGMLTAAQKLNRKEILKQHKKEVDAVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJA7</accession>
    <name>A0A2S5BJA7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJA7"/>
    <dbReference type="STRING" id="741276.A0A2S5BJA7"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="135" mass="14643" checksum="8BB9B4934F4C17C5" modified="2018-07-18" version="1">MAAPAAASSSLSGKMTQLWNSPAGPKTVFFWAPMFKWCLVAAGIKDLSRPAEVISVPQNLALTATGLIWVRYSFVITPVNYSLAAVNLFVAGTGITSLYRAWDWQRKSPAEQASIRLQNEEEAQKAKDAVQKIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZJ4</accession>
    <name>A0A2S5AZJ4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cation-transporting ATPase</fullName>
            <ecNumber evidence="1">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_7039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000157">
        <property type="protein sequence ID" value="POY69960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZJ4"/>
    <dbReference type="STRING" id="741276.A0A2S5AZJ4"/>
    <dbReference type="OrthoDB" id="3270005at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="3">
        <location>
            <begin position="272"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY69960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="448" mass="49983" checksum="5C31FBB3BCA2D02A" modified="2018-07-18" version="1" fragment="single">MTEPQGILKAREPTETDVSEFFTQEDLRDATAFQRPAEEEDPEAAGQEDDYDDPDGALWSGPAARSVPTSVSGFRMRARSRGELDRHSREYERQDDGDDARSQSRRRRRSSRRGPGGGGADTDTETLRSRKSRRARSRRSSRRDSDASSDTSEVGFFEGLSNVFRGRRPASVYSRVVDDDAVSLTSERTEDDDPYGPYGSTSEESASDESTSSNERGGGFPGISSGGDFFGSGGAHESRISMDEDEMSSLSESSDEGGEERMCHQLVYIVDEDLPLRFVGLHLCRSWLFLWYFGCVVTAGGLWLVGRWLPNLWRKATGEMEIFAESDYVVVETHHHATQILRLETLKLPQPVPLATLFPPSVQIPPAHREDAATAANNTPENGSVDGVEPPATVKKHKKNGGPTVDELKFVDYRYYRFLLHPDGMFRMIRDWKDPTWTSIAALRHGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZJ8</accession>
    <name>A0A2S5AZJ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">BMF94_7067</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZJ8"/>
    <dbReference type="STRING" id="741276.A0A2S5AZJ8"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY69935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="92" mass="10336" checksum="36E2F90C255BD8E0" modified="2018-07-18" version="1">MASNQIAEPFDLIRVSLSERVFVKLRGDRELKGVLHAYDGHMNMVLSDVEETIYVVDTDDTTQESVVRTVKRNCDMLFVRGDGVVLVAPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZY2</accession>
    <name>A0A2S5AZY2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6927</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000150">
        <property type="protein sequence ID" value="POY70065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZY2"/>
    <dbReference type="STRING" id="741276.A0A2S5AZY2"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="68"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="624" mass="67779" checksum="9EC16A0C353BBAAF" modified="2018-07-18" version="1">MATTTNAHFKLPVIRNEPNLHYAPNSPERQQLQDVLAEMQAAAPFQVPAFVGGKEVNPSGPRSEQPMPHNHKQALCTFPTSTPELAAEAIEHALGAQAAWESMPFNDRAAIFLRAADLIAGKYRAKICAATMLGQGKNVWQAEIDAAAELVDFFRFGASQVEQLYAQQPSENSAGTWNRVEYRPLEGFVFAVTPFNFTAIGANLVGAPALTGNVLVWKPSPGATYASWLVFNILLEAGLPKNVIQFLPCPNGDATISLVDKVLSHRMFAGLHFTGSTHVFRSLWKQIGNNIDRYLSYPRVVGETGGKNFQLVHPSADLRASVIGAIRGAFEYQGQKCSALSRLYVPKSLWEGEGKFKEMLVAEVGKISVGPVTEFGHFMGPVISQGSYDKCLSYVEKAKQAGGEVLAGGVGDNSEGFFVQPTVILTKDPRSPTMTDEIFGPVLTVYVYEDAEFEQTCKLIDETTTYALTGCIFSNDRAATVKASSLLRFAAGNYYINDKCTGAVVGQQPFGGARGSGTNDKAGSISIFYRFVNARSIKESFTPPTDFAYPSNLHILWSQLAFVGISEASQPLQQAERSSAARSGDSSTNDKAGSISIFYRFVNARSIKESFTPPTDFAYPSNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B006</accession>
    <name>A0A2S5B006_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipid droplet-associated perilipin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B006"/>
    <dbReference type="STRING" id="741276.A0A2S5B006"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1230">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33274" checksum="8F13583C322172F3" modified="2018-07-18" version="1">MSIQAVNGDSHAASEKQSVAQHDTALHRVTDYPLVKDTLSTAHDFVERRPYLNSLYSRTLSLSLAILHRLEPLQKRLPLETADGYANSALDVVEKYVPQVKMQTGELLGLARQPADKAYGRANDLKEGLQQHVPRPSLSARRRGFPPGKDRISPVTEQVHQRIQQSQSQLSALQERLKKQIPHDQESLKHTLDSILAEVDSLVKSVQTIPSHAQQTAKPYLDGMYEASEHIKKEITRTDVPLGTKASNVLAYSQEKLGPVIEQIQHYLLKKKDESAQTAEDVKDKAEDKVDAATSDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B032</accession>
    <name>A0A2S5B032_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000141">
        <property type="protein sequence ID" value="POY70137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B032"/>
    <dbReference type="STRING" id="741276.A0A2S5B032"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="175"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="251" mass="26334" checksum="4307D031CF36DFCF" modified="2018-07-18" version="1">MPRLPASLGSWTARAALPRAHSATAAAAFHSSPLVQSHVGSAPVPVPSTVQIDLPTLPAAGTAAAPAHAVVRGPKGQLAVQLASFVRLQKQEQQPDQASAAGRPHYVVGIEDATVKHQRAVWGLTRALLANAVVGVSEGYTLPIRLVGVGYRAAVEDIPPSAAVASADPARQPKQRLNLKLGFAHPVLIDLPPDVTATTPAPNAIALSGIDKQRLGQVAAQIRAWRVPEPYNGKGIFVGDEQVRRKEVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B051</accession>
    <name>A0A2S5B051_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B051"/>
    <dbReference type="STRING" id="741276.A0A2S5B051"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="7">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="108" mass="11796" checksum="67E447C10C9B3336" modified="2018-07-18" version="1">MSFGRPSNTSLSLGGAPPQKGSFPLDHEGECKDYMVRYLKCMKQNKQTSTDCRHLSKEYLACRMDKGLMERTEWDALGFQEQEKGAGAAGTQPTAQAKHTQPPSGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0H9</accession>
    <name>A0A2S5B0H9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000132">
        <property type="protein sequence ID" value="POY70287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0H9"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="388" mass="41769" checksum="FA3CF005F57F4E50" modified="2018-07-18" version="1" fragment="single">TFSIPAVSASLRSSFDARLVPSFRFTVNLRAARQRLFIRLSNRVSTAGPLPATRLDSLFTKAAGSTLFSRSVCPISHYATATSLNRKMVSFLSKPTILFLSFNLLRVLSVVGLCLVFASEIVTINSDVKGMRAEQNRNATSSISTATPSTTASINILRRDFVGHSLETPAAVRAASAAFSPASSAIPPAVPTRLIRVHRMAPHAGVFAHLERREPQLSDSSEQRHPSKSMSTASSASTPGPTATNAPLSRTSDESVPETQTCAYIGQTSIPKGTAGALFSTLDRIFASFLLLLMLFSELAPPFPPLSRPATWVHRFWSSFFPPFSDEYGVGVLGAVEVFVSCQVLSHATSGWIQVSSWFLFIVGILNMLAGLAFGARLKVVRSLSKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0I3</accession>
    <name>A0A2S5B0I3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000133">
        <property type="protein sequence ID" value="POY70283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0I3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0I3"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="85"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37314" checksum="1E779CE0CF965713" modified="2018-07-18" version="1" fragment="single">MTARPSMEGAAHRGHRAGIQAGQSRRRGYLCKPKKCRQECKKSCPVVRMGKLCIEVSPSSKIAFISEELCIGCGICPKKCPFEAINIINLPTNLESQVTHRYSANSFKLHRLPTPRPGQVLGLVGTNGIGKSTALKILSGKLKPNLGRFDAPPDWQEILRYFRGSELQNYFTKVLEDNLKPLIKPQYVDHIPRAIKGKQSVRQMLESKLELDNLADVSRDLDLDVIMEREVSQLSGGELQRFAIGMSCVQAADVYMFDEPSSYLDVKQRLNAARIIRSLLKADNYVVAVEHDLSVADYLSDFICCLYGMPSMYGVVTMPFSVREGINIFLDGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0R5</accession>
    <name>A0A2S5B0R5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0R5"/>
    <dbReference type="OrthoDB" id="2528204at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="285" mass="30656" checksum="B110798628B55E82" modified="2018-07-18" version="1">MAPSKVSQHIFHTFVPVVLLVAYLVALLAFLAPTPILADRVYLMHVSAPVSAMAVKPGRRYVLSNSTEIAKSQPRHKRDEAALDKRQGTIMVPVAIELQIGPLGACYTNVTAGDKACQAPSFTPIFSDLYDDISLPTDVASTLTTQFPFSPTFLFISLCLMFIQLAVLAALALGCHKPQGNLGFIARKQHRLVRVALIIGVVSLALGLAATGALRVICGSDVKAARDIQGVEADIGSGFAQLWAGYTLQAVVMILLVFEFFMTRPRKGKNIVPIEIKTADSPLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B126</accession>
    <name>A0A2S5B126_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B126"/>
    <dbReference type="STRING" id="741276.A0A2S5B126"/>
    <dbReference type="OrthoDB" id="2522913at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="472" mass="52038" checksum="FC701E94C722887E" modified="2018-07-18" version="1">MADIFTDLLDRTLRDLPHDANPWVAIRTALTGRVRPEAPQSFIAQLYTLSATTAVVTVILSACMFVKYRQGTLWLMRTHRATGGNYLVVHYSNGWTTAFLLFLGVLQGYIWQTIFYNQGKWVAHSDIWRMVVWIPGWTAFWLASWSLCVSHILHLDSSGRPARSFYAQAWFVNVGAIVVPSVAAVIIAVLAWQAHRRYWNSLEAYKAIDAALASYTGVFDLSIITTGRGGELVKQFTRSLSGFGDYFRWVFVTYLIATVLLQAVLCLTAYLHLRELRRTMQDLRARANVSAEAKAQEALIKHGYRSLLYVTCSIIAACTAINALFLFVAAAGPKVVYDRNYSEVASLLPLWLFAVLGLPLSILFLRRLLHASPAPVLRKGDDGIASPVVIDSQLPTSAKDVEGGDAYALEKLSALKYGDMKHAAASLDSDAADSLDTSAAGHSVVPLVTHTPPPSREPQAYYSSYSSRAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B152</accession>
    <name>A0A2S5B152_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_6423</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B152"/>
    <dbReference type="STRING" id="741276.A0A2S5B152"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16534">
        <property type="entry name" value="RING-HC_RNF5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY70509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="289" mass="30749" checksum="F4C3B1B34400F5B0" modified="2018-07-18" version="1">MQRVDSPERAQADADSPPAPGPAEHSSPEAGSWGMPSSDGGRPSGAAALEPDGAVIETGNATPVQEEEVAAETELDKGVTREDKLDRFSCHICLEVPDEPVVTPCGHLHCWPCMHEWLVTSRGRACPVCKAVLTVEQLVPIYTSAEAIDPRSRPIPPRPRPAAPPPSAPYFRTPAFRNPFASLDPGSEIEAITSGRGSTSSFSFQAGVFPLPGLSFGWSWPPTPAAVAVPAAAPEELDGRAQGGRVGVMMRDPHGAARTPSRDEWFRAVVQQVFMAIFFAMFIAITFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B155</accession>
    <name>A0A2S5B155_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B155"/>
    <dbReference type="STRING" id="741276.A0A2S5B155"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="140"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="521" mass="57142" checksum="3BEE49E6063A5752" modified="2018-07-18" version="1">MPAAVLSLPAEIRFDPQVAPSFSRWVPPRWMLQHASNPPTPRQPNRNGLGEPWDPKKPTFRGIDLTKPDPRLRVPKLEIECDNPDSKVAFLDVNILDSTGKDPYRGDVLIRGKRIVSVGDKLSDEQLAGARVYHGEGRTLMSGMCDAHTHFSWTNSGSLDGLATMPAEEHTLFAARSARTFLDCGYTMCHGAASAKQRLDAVVRDAINSGEIPGPRSTANGQEIAPRDGALIAGITRFADTPEEIIAAINDIADQGVDQIKLSMSGEEITEVLRAEDTTFSDELVAAAVEAAHARGVRVCSHARSDESILQCLQFGVDVIYHASFISDSTMVALEAQKNRVWVAPALAWLYGTLEDAESFGYPPTKAESVGYARELAIAVPGLKEMHRRGIRVLPGGDYGFAWTPHGTYRDPELFVTKLDYTPMESIIAATAMGGELMMHPEELGKVLPGYFADVILVNGNPLDDITLLSHHENLDVIMINGRIHKEQDKDHPASYEAKGSMIDKQQYHDADHYKREVGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B193</accession>
    <name>A0A2S5B193_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B193"/>
    <dbReference type="STRING" id="741276.A0A2S5B193"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="642"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="947"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="829"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="572"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="843"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1105" mass="114131" checksum="30C2819571986470" modified="2018-07-18" version="1">MAGSPFYARTTGQLSPAGGVQTGYFGQLERSNSTGSAWSLSPADAAPGTGPTNAFDEQRLMSRSPGVGAGAGLSPASSSFQNSLDPSRHYTALERRPSRDAHGDSTVGTIGEGRKASSSTSVGTVGAIGEGRRMASSTTPTTERREEEAFLGLPTGYFNPDGSLAAPLVGSAGSRANGSDSSPSPTKSRPSSFILDVLPQTRERGGPPTPSLSLDSVSQPPASATDLFPLPSPHSLAPSSYLINSTQTSYASSPQSQAGHLFGGSSRTSSPGPIDGPASGPSGSPAVDALASKVRVLESNVSTLSNVLATEFRSLREELGLLRSLVQQQQQYASQNGGDRSDRDGSPVLTLRSPSPNTHASQSSRTPTFPHAIPLARPTLSSSLNGSMSSLHVQPATSPGAVSPSSSVASGFFASQQQQQQPPLHADSGPTDSASLKDEQIKLLTAQVNSLTSTVSTLLGSPAMPSNGFAPTGNASPMLNSSTSGSMPPMPPRGMTMPLGGSQALGLAVPGAGNGLGPSRVPPPMMRTASGTGLGRNASMRSANGGLGAGSFDAAPMMSPSPSLQGWPEQPSGPASSAMMTSASAGGASAVGSPMIGSSGPGANPPGSLGSKWEMLGVGNELFRAVAKFGLGPPTKIQGKSIPSVIRGQDVVAQAPAIQERIQCYVIPALQIIYAHATLAAQIAAAEGTQAPVPGIQVIMITATVDQAAQAQRLSVGLGNALGIRTALCTGSSHDLQNEAQNLLKSPPHVLVGTPQKLVDLFSLRIVPTSSVRLLAIDECDQLIARNLSEHVIALSRLLPATISVPVSGVPAASSPVLNRSGLPNGFDSPYSAPMSRFGSTGGPTSSQGMPQQAKPTGPPSMTTIDRQMAVFSCTVPQDVLAFATSLQLKEPVKVLVRRENTDGGASPSMRGLKQYYMYLAVASNPASKSKAPGAGRREATSSREWKLEALADLCEDHTFEHAVVFASSVESVEAVTYKLGSRAIEAFALHQDMGQNARQQIIAKFRASNGARAGQPPKRVLVVYDALSRGLSDVGQVPLVINFDMPRAVEDYVHRIACATGHNKNSMVLNVVTPSEVEMLRNIESFFRCTIRELPPNFATAPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Y5</accession>
    <name>A0A2S5B1Y5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Y5"/>
    <dbReference type="OrthoDB" id="2529919at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="949"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1106" mass="117629" checksum="426F2CB80D5EB996" modified="2018-07-18" version="1">MGSMPIRQTQDDDASDDEILLVAPLLATTSAASLRTPAAAAHSNNRQEAPPSERATRAKGPRRSEPYLCLPSNNNSSTKQTRDAANRSAKRRKTLADLPTAAGLVLSRDGPGAVVLTPPVSKSNGPTSRISSPVPVRQHTRWTDDASGSSSKRISYYSPPQSKRAAPPPTSSSSLLELSSKQDGLVADRPSSSSAPPSKRKRTRSPTFDLTITRSPPSKSGSNSPPGRGAKRKEVEAHLPSPVSLPSPPLPTVATAAIGSENFRAAAATAPDPGSQPPSKRKSSSRSPPQSTTFELVVPARARPPRRSVTPQAQARLSEVEAQGPLRGSATTSVVPPLPPFPNKPAQHPLNSLRLRPPPALPALSRFWRNDDFPPARDLGGWIAPCAVAAKGKGRMTMTSSRSREETPISAAVTAVFSAAVQSDGAGTSIAAVARLAVSTDAGAIASTSRLPTPAVPLTKPTVAKPPSFKSWMKRRYEFLEPYETSRYKIDGSTLGLDPDPLSYEWDEDELWSDYEERYGWEERERVARGEEEEVEEEDDDEGSQQDLDGEDAELPPPRPRMACTVGEGPDVMFGSEYISKLCSTAITTGTEAPSAEALAAADHLNELTQSRGLVRQFPWRWRSLEEGKGRAGNAATKWATRNPYMRGEPDPYEQSHGRRTTHRARKALEDKARLGPAQRTMGVLRVSPSLSIASDSTTSAGSSAGLGRASVGLSTSRTVSPELYATNAPTEVVSAVESNESLRSGRPTSGGPLYDPFRLPTTLSLPFGSFSGAVAVSATPALFPVNVVQPGAQPLLSGAFTNEGPPLVRKDVAGGKSPKLLEKAVRSAPIPTLVLSDDSSPEPAEADRLPFGARAGSADSDDPIALLADDAPKIRLVRQRPSQDDATPRRSRKAARPPTHPSDESDGAARSLDETEDASSEASEESGYPTVVGGSSRASSPALAGTASSDGSSPAPSMSSSPRIFQRLAAPPTVQRAKPRASASLVRKNVPSPKQRTTQKSAATPPRRGRVPKRNTPPGNTRCTLPTCPSPFYKAKAASSLKTHERNYHYPTSTLHYKSRGATIIVTRDASEHAFVCPFCPHWSLNSSSFAQHVDRLRCSGGAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Z6</accession>
    <name>A0A2S5B1Z6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Z6"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="313" mass="34043" checksum="0FBA9E017A19BAA7" modified="2018-07-18" version="1">MSAQYSYSSGSDSDDDAPEVVSQATARQGRKEQERQARLAKEQAAKARKQAKSKAAASKDVKGKGKAVEPEDEDVDELEGDEAAYDEDEQNYEEDEELAEEDDDEASETIAQAPPQVGKKTTYLDDSLFAEAAAHYDTGDRVPPGQGKKSQRKLAKAEKRRKREEIARRKAQVGEGGQQQVGDITLQHLSTSSIGPASLSSTTLPSHSSAAKFVAKRLYSKKRQVAVLDQGRPQNQERNPKKQKGMSLESKILLGLADPEDANKAKDKERSRKKSLLLQAEGQRKSATVARPLASARRGSKPAANFAVSSFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B201</accession>
    <name>A0A2S5B201_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B201"/>
    <dbReference type="STRING" id="741276.A0A2S5B201"/>
    <dbReference type="OrthoDB" id="2528206at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015695571" evidence="3">
        <location>
            <begin position="22"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="404" mass="40829" checksum="EADF2652FB28F972" modified="2018-07-18" version="1">MKPRGSLWLSALLLGSAIAQGQAPAASNSASARNSTVSGQPSGAATLRTTIQLPPLYSCDFSTWTYTAPAGPKYLGFYVSGTTSWIETYSLPTVYDDRTNGTFTWKCDLPAGLSVAAMFYVVQNGASGTNGAQASTPDALINAGSGGLSCLGTNDAGSQAKILSLASSLDPSFFATSSGPQASSGSDAGSGHSDTNIGAIVGGVVGGALGIALLGALLIYLKRKHDNAAWNGGDGLSVYSGRSEKVGSTYPSHFGGAPMSLGPAGHAPPSESLAAPPPGTYYAADANGNVHLMMGYPSSADPETPIAPPSERTLASPISKPTAPPGTLPEPMDDSEEVLSQVSPASRGADQLSVAPSTLMRAASPAVAPQFQPAAERTGVLGLGAQGLDDPSSFSPQRQTHRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B256</accession>
    <name>A0A2S5B256_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B256"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="2">
        <location>
            <begin position="281"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="516" mass="57145" checksum="8A756113B14B3892" modified="2018-07-18" version="1">MASARTPRLAYRVTATYTSLTLARRSLHAALTAVDTARRSPREPDRANDAPQTTPPSAAAYIAAQAAAEEAAEAEALSAGEVKKPKVVPDPDAWQGDESRERMLRRILEDQYKPLRVKGYQKPIPQPAPLPAQAFESTEPMPSRPAPSDSSRPQNPWDVVFKPPDHYQPLPGYRADDAGRGVVPGSGISARKAAIAAARKDASLSSRPSVYKKQRLASAYERSLDYRGGIRKPSGSVRSGLGSGGGFDLMSGRGISVPVHETQAGQNAGGQAQDFQIWEGWLEEKIKQARRDGVFDNVKGRGKPIEREHAESNPFIDRTEFLMNRILKTQEAVPPWIELQRELDAAIAAFRTELRANWTRRAIRIRSTEGLTGAVVREVRDGWTDSEWLARERSYHEVSLKTLNEMTRKYNIIAPYNVRRPLLTLANELKDAIKSCAPSIATELQRRLDHGMGTVTSRGLVIKDSGEIRSMTADDLGGEQEADKKDTMWRAFRRVLVEVFAKGPDEAPPLKRVSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B279</accession>
    <name>A0A2S5B279_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B279"/>
    <dbReference type="STRING" id="741276.A0A2S5B279"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="214"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="298"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="502" mass="53954" checksum="BC6F9F8F2CEE11AD" modified="2018-07-18" version="1">MSDPSTAAANALGAAVAPPPPPKPDGTPQPAATGRMCSNGCGKQAGTLECPKCQGQQCFASNYPKHHKKMHVAAPRPGYDFPEGTKDGFDGRYKYTGKLRSVMPVEPVPKRQVPDHIPKPDYATESEALESIPARWSGVWGGRVFGQAEEVGRTIAYGLGDNGGTDALVALFCLLRSSLPLWNGAMTENGVSFKEQVANRVERSGRVLNAAQIEGMRKVCKLAREVLDIAASHIRPGITTIELDQIVHEECVKRDSYPSPLGYHKFPRSVCTSVNEVICHGIPDSRPLEDGDIINLDEHLDLIACSRECLDEAIRMCKPGTQYQDVGKLIEEIATKRGFTTNKTYVGHGIHESVDCPRSLAETAAWHRLFHAAPNVPHYAGNRASGTMRPGQTFTIEPMICVGHQKEVHWPDDWTAATPDGKFSAQFEETLLITPTGVEVLTAAPGWQLPTKPAAANGSSSTSASKKKKKKKTAAQKAAASAAGGAASTQDGEAIDEDETAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2C4</accession>
    <name>A0A2S5B2C4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2C4"/>
    <dbReference type="STRING" id="741276.A0A2S5B2C4"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PSMD12/CSN4-like N-terminal" evidence="9">
        <location>
            <begin position="55"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="324"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="468" mass="51321" checksum="AF4E78931E84B347" modified="2018-07-18" version="1">MDDELQRIAALPQKDKSQAYLALLKQTLVSSSDLPRDLARWLSVVVGADFPQIVARQVLEGYVSKLPSIEDREARKAVLKRSIELLQPRVTSFEEEICTLRERYADLLEADEEFPEAARVLIGIPLESGSRHVRLGPARCTPTDRGPDEYKLRVYVRIIRLFLEEEDSTSADTYFNRASLIAHVATDLETKISFKLCQARMFDYSRRFAEAGSKYHELSYVTDLAEEERMHALGAAIVCAVLAPAGPVRSRLLASLFRDERSVQSEHYSILSKMFLDQMIRPAEVSAFASKLATHQLAQLPPTQAIVIADDAEAEVGKKGPETVLDRAMMEHNVLAASRVYNNIAFKGLGLLLGLKPSAAEAMARTMIQQKRLKATIDQIDGLIIFDVDTREGGDAAVSNVAAQAAAREDDGADAGDDGGAAPATKRWDLQIRQTLQLAEQIAARCEVLLAEGQSAPTSAAVAVSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2F9</accession>
    <name>A0A2S5B2F9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like protein ARP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin-like protein arp6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000091">
        <property type="protein sequence ID" value="POY70972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2F9"/>
    <dbReference type="STRING" id="741276.A0A2S5B2F9"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="496" mass="54434" checksum="55F948A23B5859D5" modified="2018-07-18" version="1">MQTPLSPRVLVLDNGAHSIKAAWADPAAPSLDPPVTTFRNAIARSKTAKRNFIADELDLDCQDFGGLTFRVPFDRGILNNWDVQKTVWDRVYAGKGKGLAINPQETNLLVTEPVHNLPNVQEHYDQIVFEEYEFASYLRCPAPALVPYGLDARGAPNAPPPECALVIDSGFSFTHIVPILRGRVVSHAVRRIDVGGKLLTNYLKELVSFRHWYMMDQTSVMEHAKEKVCYVSTQWDHDWETANRDTHNPIVRTYVLPDFVPTSTNKLGYVRTGLTPPPPSPPPPSDPDVATFVPPPKEEEEEQLLHLCNERFSVPEVLFTPSTIDMNQAGIAETVATCISLLPDSLQGLFWSNIVCVGGSTAFEGFADRLRADLRSLAPQDFDVRVTVSASPTTVAASSAASYLSLPPASPLRTTFSTPLDLSSFVTRQEYQEQGGSNACRRKFGRFYLRSEGKEDVERWVFGGGAGADAAKLGGAVLPPLGMMPPLPPLQGVAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2W3</accession>
    <name>A0A2S5B2W3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2W3"/>
    <dbReference type="STRING" id="741276.A0A2S5B2W3"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="179"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="923" mass="96710" checksum="B7B07D4505C3FEA6" modified="2018-07-18" version="1">MPHGPEPLEIHLESPDIVLRGFTGDEFEPAVLNGQLVLNLAHPTDLKEVALVFTGTARISWRDSSTHHHDHPLFFHDFNFLNPSAHTNREDSRREHHQVHTLKAGRHVFPFSLTIPGSLPASLRTYTGTGVIEYKLKAIAQRPGFTAADWKTRKIVRVSRSFGADAVEFNQTLEIENTWPGKVMYSFTLPHKAFAAGDTIPVAVKFSPLAKGVRIVSLITTIREHTTVYSKSSSHSEARDATTVKYSFVEGGSNPPSATPSGMNTPGLRFGSTASLSSMGGPATPTTPGFNSPIHGSRTPAIERGGNDGYPFHMTRPGRRARFQLGADEEDDDAHAHNPTQASTEAGPAEEDDGQDTEVDVVVDVQVPVWTAPSHSVHPVFVNHKIKWSAFIKNPDGHVSELRCALPIHILASNLQEEARLASAGSRNLLFGPSGALAHSDVPQVDLPSYQDHIMDRVANADTAAQYSASSGFAPTPWSSRTTPTGTPGVSPPASRPPSRPASPERRSSHSERRTSHHSSFGGFGGFSALSSINRSGTSTPATSSPPPELADDAQDAHPEDHRNWVDSELLSTLNLNEHVSPPSSAPASRPGSRPSSRPSSRAGSRASSPDRTSIATSIPVPSTPPTLDERPALSRSHNSGSFFNLHIPKPLRPLTSFSRNSSASNLRDALHMSSHSHGHPSTGGSDSRRPSTNGSDSGAPSPSALSSALAAHAARAGPSGHVARPPLAVDTPSATVIHAMMSNSPHGRSTGSAGGASPISASPAQPSPLLSPGISGNANFHLHYGSITSPASTPGLGPGTPLRVGQDGSTSPSLLSSSAPSPGPPPHGQPVDVLSQVPSYDVAARGFLGGGVVPLSFNPPNYDEVCPSTDGSRAASPQGARPSGEAVRDAAPGAPPTATQEQPAAGLQATDFGGLSLGVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B331</accession>
    <name>A0A2S5B331_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="12">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_5503</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="12"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B331"/>
    <dbReference type="STRING" id="741276.A0A2S5B331"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="67"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY71192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="335" mass="36717" checksum="C2C60DB89ED5EF30" modified="2018-07-18" version="1">MRRTQGLRRPTGNTVSRSTSSVSEGSAKWPTPRSRRSWRPLLAGAGLLAAGLGLFLSWEEAPTLGGDRWTTVKIKSVTPMTPETSLFRLEVPRSVLPPAFDSDPSARPILSLFVKEPSLQIQRAYTPLSASSFNSRGPAELDLVVKRYPDGELSRYMHRLGPDSELNVRGPSVTWWYRPQDWDEVVFIVGGTGVTPAYQFVNDMLRDSPAPTTTDRPAVSIVYASPSPSRILLKTELDQLAQADPGHVSTRYFVDRLDVAREPAPSDVTVGFLDRGNVEKAIGRRVAGKRRAVVVCGPESMIEAVAGPRGRNFSQGRVGGILQQLGYSDGEVFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B334</accession>
    <name>A0A2S5B334_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B334"/>
    <dbReference type="STRING" id="741276.A0A2S5B334"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000312">
        <property type="entry name" value="Ran binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="265" mass="28623" checksum="A713BECF32C39D03" modified="2018-07-18" version="1">MTTAVSAEEPTTAPAAAAEDESTATFEPVVRLSETVQVKTHEEDEEALFKMRAKLFRFIAESSEWKERGTGDVRLLQHKQSKKVRLVMRRDKTLKVCANHYITPEMALSPNIGSDRSWVYNVAADVSDGEPTAETLAIRFANSENANLFKKAFNEAQETNKSLLSGSSAEAPTPVESDAPVAADATSVTQTGAPVEKGKEVTKEVEAEGDKLPEYKDEGVAPPPEKTEVVQGEEVKQPTEERPVEEDAHAATKESGPASAPAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3C2</accession>
    <name>A0A2S5B3C2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_5512</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="14"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3C2"/>
    <dbReference type="STRING" id="741276.A0A2S5B3C2"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="960"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY71201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1031" mass="109684" checksum="79BEF9A45C3E4966" modified="2018-07-18" version="1">MPSDLKTPYSHLLPTSSSSSAGPATASGSAGSTHASGDSTPTHAASRSSSPAQLPADDQHYAYSTQLRRHEPESIVDFAAHHNPLGDLKNPFASAAQSTGNAAQQHGGAAINGVYPPAASSSANRRNSGHHHPFAHTATPLTPSARFATQSIAQTLASLGTSASKGMDAGKVPAIRELSGANEFEVEAKDPVWKKFITKFYEDPLILLLLASAAVSVVVGNYDDAASILAAIFIVVTVGFIQEQRSEKSLEALNKLVPHYCHLIRNGQKTTVLANVLVPGDLVTFHTGDRIPADIRLTQAHGLEIDESALTGETRPARKQTEAIQDASIGLGGIPISERHNIAFMGTLVRSGRGEGIVVGTGVQSEFGVVFSMMQEVEEKKTPLQVSMDELAKRLSLISFGVIGIICLIGVIQHRSWLEMFTIGVSLAVAAIPEGLPIVVTVTLALGVLRMSKRHAIVKKLPSVETLGSVSVICSDKTGTLTTNVMTVTKAYTVDHGIFDLDRGAITLSTSDSRAPMFLVGNLCNHAHADKGKFHGQATEVALVNVLQQVGLSDQRPSFTRKSEVAFSSDTKSQSVTGSFTHAQANAPDTTYLSGALEPVLARCQTYLREDNSTAPLDAGVSKLISSKAVELASMGLRVVAMAYGSEPDALVFAGFQGMMDPPRPGVADAISRLSAGGIQVVMITGDSEETAVAISRQLGIRTTPGNSRMGVLTGKEIDALSQRQLTDRIGGVTVFARTTPRHKMAIIEAYQSRGAVVAMTGDGVNDAPALRMADIGVSMGRGGTDVAKEAADVILVDDNFATLLPAVEEGKGIFVNIQNFLCFQLSTAVAALSLITLSTALGLPNPLNAMQILFINVIMDGPPSQSLGVDPVDREAMKRPPRPKSAPILTRRLLYRVAFSASIIICGVLFILAREEGDGSDLARDQTMTFTSFVFLDLASALQNRGLNVPLFTGNPNKMLLLAVSVSFLVQLSFIYIPFLQSIFQTQALSLRDLSVLLLLGGCSMTLHEWRRRFERKQLVEEAWSSSQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3D8</accession>
    <name>A0A2S5B3D8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3D8"/>
    <dbReference type="STRING" id="741276.A0A2S5B3D8"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14096">
        <property type="entry name" value="STKc_RCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="143"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="533"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="282"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="653" mass="71252" checksum="620521153F5FF010" modified="2018-07-18" version="1">MPIVSVLKGLLHKNNERQPAASAPVSTAAGATSSAPHSSSTSRQPAASSDVNPSIAHPPAAHLAPVNAKSLPVTGSTPANASAPTGQAMAASNAGYQGGAAAAAAQNATSQGTHAQAEEIVRKENEAKAKREQSVFDGLPDGLTLGRKMGDGAFSNVFEATYRPSPAQLAVDPKLAKEVKVAVKCVRKFELNSSQRANILKEVQIMRGLNHPGIVRLLNFTESSNHYYLTLELMPGGELFHQIVKLTYFSEELSRHVILQVAHAIRYLHEEKGVVHRDIKPENILFEGIPIIPSKVPRARPYDEEKEDEGEFIPGIGGGGIGRVKIADFGLSKIVWNEETMTPCGTVGYTAPEIVKDERYSKSVDMWALGCVLYTLLCGFPPFYDESIHVLTEKVAKGYYTFLSPWWDDISASSKDLITHLLDVDPEKRYTIDEFLAHPWCKAKPAPTAVTPGTLDALKLKPVPKYTPLDSPMLATGGRRAMPSPGIATLKEAFDVTYAVHRMEEEGKQRQRAYNGPGGAGRAGFLQGLNEADEEEEADIEETKRRYGAEVSKAIEEQRRQAQDPSRRRAPQTAEEQARAAREYAGWGGADRKQAEAALYRDHGRAGQRDRGRKQRGIDLSLDAASILSRRKKPMMDGQQPQQQPSPMRMQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4J6</accession>
    <name>A0A2S5B4J6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonyl/alanyl tRNA synthetase SAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4J6"/>
    <dbReference type="STRING" id="741276.A0A2S5B4J6"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="61391" checksum="BC725DF8C6DDDA6A" modified="2018-07-18" version="1">MLLRRARLPSLRFFSRPISIATMATAAVAPSSTPFSSSPAPFESTSYAHVTFPLPEKRYVGMLHCQRDPLASTLVTRVVRCDKVKVASLPAAVASKAAGKGKKGATAAAPPPSSSSEASPAPAEEWEVELEDTVLFPEGGGQPSDTGRIIPLVEGQGSSAAAGEPAQVRQVIRRNLDAVHFVSKPLEVGSQVRLEVDMERRRDLMDQHTGQHLLSAVLEHEYKIDTLSWSLQKFPELCYIELPRAPSAEELASVQQRCNELIGEARPIRVKFELATDETGVQLGEHVPSDYKAGDKEDERPPVQRTVIIDELDENPCCGTHYPSLAYLRTLYISPNTTSIRGSNSRIYFCVGSSRVLAYLASIQAPARQAALEAGCGLNDLPGKVEGLVSATAESKRREKRLHAELAQYVAKDLWLRAATLSGNDASSHDGTGGPIRAALLREEDATNSLDFLGTVSLELKTLADSAAAAARQQGDSQGQQQQQKKHVFILACGATAGTPHAVAAGGAVLITGTDEVAVANAGKRVVETFGKERVKGGGKGRWQGKVTGKWEKGDDLLLDRILEEVVGQAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4S3</accession>
    <name>A0A2S5B4S3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4S3"/>
    <dbReference type="STRING" id="741276.A0A2S5B4S3"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="428" mass="47993" checksum="0386F7618E72589E" modified="2018-07-18" version="1">MSGNQFRGTSLDQDPRFRDKQAALMRKTAFPPSFDTKVDMRKVEMAVMKPWITKKVIEMLGFEDDVLIEYIYSLLEDPENPVVDGKNMQILLAGFLEKKTPAFMSALWDLLLSAQSNPLRVPTALLEEKKREMREREQQEAIKRRQQEELDAVRARERGGRAGRGGFGGGGGGGGPPPHQQGHGGGYGGPPRRDGPRYGDGPRRGGYGPGRDRDAGYGGGRGGPADYRDDRPNPRTVHLPLAATSGRQALAFSLPLPLPLPLASARSWRSYSPDPRGDDRRRPRRYSPSPEPVRGSSKRYRSRTRSRSPPRARQRSGSPPPAPSRGAGKQRERSRSRSYSPEAPRRRRQSPSPARDAPRRPRSRWDRDEEDERSPPPPRRRAERGHDREVSPEDGQGRETSLADREGALKEDLLRKKVEASRRSRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4U0</accession>
    <name>A0A2S5B4U0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BMF94_5164</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4U0"/>
    <dbReference type="STRING" id="741276.A0A2S5B4U0"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0521">NADP</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="18">
        <location>
            <begin position="29"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="17">
        <location>
            <begin position="194"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="POY71803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="421" mass="43687" checksum="8A61E78CF95BA3DE" modified="2018-07-18" version="1" fragment="single">EHDESSRKERSSLIYAPPAVSACAVAIVGVGLVGKQVVHQLTSPALSSLFKVVSLSNSKHTLHLSAAAPALDAETLLSLLPPSSAPLPSSSAHPAASYVAADPAELVKRLAADARATKSASNAAGQHTILIDCTSDLSVTELYPTAIASGLSVVTPNKKGFSSSGELFKQIVEAQSAPGSGLVYLEATVGAGLPIISTLRDLLKTGDEVTKIEGVFSGTMSYIFNEFSKPGGGAGPKFSEIVKVAKENGYTEPHPADDLSGSDVARKLTILSRLVSVNPSTLPALPDLPEGYASLSTQTLIPSALSNIASGEEFVAKLPEHDAEFDQLRSDAAKEGKVLRYVGLIDRETGTVKCGLESYPASHPFASALSGSDNIVAFHTKRYSQRPLIVQGAGAGADVTAMGVVADAIKVAERQGLRVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Z1</accession>
    <name>A0A2S5B4Z1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Z1"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Z1"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015592066" description="Prokaryotic-type class I peptide chain release factors domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="68"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="202" mass="22635" checksum="03490F1F1331B5BC" modified="2018-07-18" version="1">MLSAGMRPVLVPSIVASPLLLRCLSVSAPARQLPQPPQLHKLETQEDMQQARSWIERFEKVRTDAWPKNLVETSFARSSGAGGQHVNRTMSKAIIRFPLPSAFFIPPYLVRHLRNTPHYAASPPSLLISASTHRTQHTNLSECFEKLKAVLLEAARRDLVGETSAEQKNRVKGLVAKEKAKIERVKKMRKDVKGGRGKVSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B521</accession>
    <name>A0A2S5B521_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B521"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="491" mass="52152" checksum="4A07340DCF9F5AE9" modified="2018-07-18" version="1">MDYVIDYLQDLTGTPLRPALGFPLPLTGLFFNPITPPPPPPVSSSSSTTSFFARRASPPPSPVALSPIASQSSSSSESPSTAATSPATSPAPPPNPKPPTGPVTRARAREMQGGAGAKGEPCSGSPAARSSPRNVKKARPRSVAGSLSAPSSRGVEATAAPRRPGKRTSAVVEEEAAALEEEPEAGSSSLPSPASAKKFKASKRESVPAPRGFRKRKERALRKKGFSGWRSPIREKPEIVTIPLDKPDASGATSFTFTFGIAECQILDSEEKGYALQKYFQERLAKKRAELKAEWAEAEAQRAAAEAPRAEKRKRASMRAAGSAPYTVKTLKARQRASTAASNSAAARHVDGSDSEGDEEVGRFAPSEAARRAGRDKVAELDSDDQATPEPRPKPKALVKARKDKERGSASRTGPRRRYQTSPSPTDSARAVPGTNDSAGAMAPAGDADDFRPREIASRIYVSGSTFCDTSFTVTTYVDGRRSVKVRKGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B590</accession>
    <name>A0A2S5B590_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B590"/>
    <dbReference type="STRING" id="741276.A0A2S5B590"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="119" mass="13884" checksum="9D41538671B67714" modified="2018-07-18" version="1" fragment="single">LSRDARADRQRDQEHDGTSPRKPAWSNWENLARLTRGIDWQEHSGPFLQKVRKADVPDYFDVIKHPMDLATLLKKVKQQSYRTKKAFADDLDLIWSNCLLYNSHPVRLRPTMRLAAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5C3</accession>
    <name>A0A2S5B5C3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor IIIC subunit 5 HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5C3"/>
    <dbReference type="STRING" id="741276.A0A2S5B5C3"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="42"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="212"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="490"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="595"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="80500" checksum="820E1C09F881615B" modified="2018-07-18" version="1">MDEVLKLPTPPPILHAPKYRLARPDQPQAAEPFQSVLPLIATVEYPGPVHSLDAALYHLGGLDTVAKALAPRAQLEQDPQHPPKQDPVAVDSHQVPLEFDFDPKNRFSHPVQAHIQSTNNIVCRVIKRKRKRPVRDADGQVVELGVYEIRPVGIEHRLARFRAMADFQYTPQRHAEADPVLDLAEAITNLNVAGIRKFNMPPPNEEFPESAFMPPPVFSRHALPQIFDMHPAPGSVPITTDSGLTRLINQGRYKIRTVQSILFVQPEVPTGPERVLLQEIGRETLSPVEEKLKKLLDERPCWTRTAILNRLSLDDHKQINANKTCWPMVSYTFAEGPFRDLVIRFGYDPRKDPEARFYQHIVLRNLSNVRTRAQPGTRAHAQAVSASSRRGDKAPTTSNLSHEFDGEHVYSKIGNFQLCDVSDPLVKSLIDSPAGVLAACSPDPNEGWFAYDYFDQIRQVLRRKWLALLQGLQVDDDDFDEMLRWDVSNESRAGQAKKGRAPAGMSGPNGPRASKSRGRSGSGSSASEEGGGGGGGFSSDDGSDDVASSGAEGGTGNGPDSGRKTDEWVSDQTEDDDDSLDSDDQAERIARAGGAESTRASRAANRAALAAAEAAAEAAAAEEAAASGSSSPAPPGPSKTTTAGAMPASAPATRSSKRLTDAGATATPTPGPSGAGRKANRASLAPWEKPKRKRAQAKQPETEAELFARINRAARRNQRISAAASSLPRIDPETGEDLDAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B615</accession>
    <name>A0A2S5B615_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B615"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="281" mass="31715" checksum="E5A921C4B60BD54F" modified="2018-07-18" version="1">MRTKLEQSAAEPAHANASPARVVRRPRPPPPRPPPPRISSIFESDELMLRIATEVAADKGSVGTGSCTVKEIRHSIHLYGTRVTRLSVVNQRWYKVCMPLLWKSIALSPWHDADRAGTRKMLAKFRTSIKTISVKFDNPTRDEAEWTRDTLSSQAVKLVHNVEFSIAVQRYGSGVFETAAVIVRTVGQRLKSLAFKLDCDSDPAEGYPVIAEMLDYTPQLEQLTVRVRFHPGRDDAFLRRDYHGYHHERLVRRARACKIKRVAIGGLGAWMEPEYDSDGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B632</accession>
    <name>A0A2S5B632_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B632"/>
    <dbReference type="STRING" id="741276.A0A2S5B632"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="103"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="324"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="515" mass="53107" checksum="AF1CF8D1C4F6E701" modified="2018-07-18" version="1">MAPKKKGQKMDLSAFLADENTGGSWADEMDTLPTGPSAGPMFGDEGALGGSHLSRNFGGGAGRDGESFSFLAHAGPGGFGGPPGRFDDRPQRAEVPIPSVPPFTAFVGNLSFETTEGDLEDFFGGLGVKSVRMAAPSMEGKPRGFGYVEFETVDGLKNALTATGSDLQGRTVRISVAEAKESRFGRADEASTWERSGPLPSLPGRSGGFGASRSGGFGDRAPLGGGGSGGYEEVERDAPLRGGKFVPSAAPERRGFSGYGGPRGGEGDRAPREPYVEVERDAPVRGGKFVPSEPASSGRRMFSDREPSRADEGSWERRGPSALPPRGAAGFGGAAPSDAAPAARRPLQLSARSAADASTDSSSTGSAAPSSRASPFGAARPIDTAAKEREVDEKLAKQRAEAASAQEARNKERDEKKKAAAATESPAAAAAESKSDGAWVRKGPLPPSSQRSNSHGSHNKAKSPSSELPPAVPVVNSVPSAAQRKDGFSYSKAAGKTEGGDVEQVTEGVEQTKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B640</accession>
    <name>A0A2S5B640_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B640"/>
    <dbReference type="STRING" id="741276.A0A2S5B640"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="557" mass="59848" checksum="23EB304B470D6B05" modified="2018-07-18" version="1">MLSRLRAPSNPCARCWASLAHRPSRLASSHARYTTDAAHKERTAPSNRTTFEPAQQAGRSNPRPTALSTLPSDHPATRPSSIAGILAQKRSYATKSDQQDRPVYAHEDLLLPSSTRGTLDRRRPRPPTSDSDATGKGKRASYFSPSYLLAEEPPLPPPSTSPLVPLSTPIPTSLPPTVLSNGLPNPDIRWRARPQSSIHDDVQLYKALGKFKLSSLVVLTTMAGYAMCPVDPGSTHAAMDAFAQTLAQTPGALPTDVTSLVPPAGGAVGSSPANNLTLSVLLPTTVGTTLCAFSAASFNQLIEAPYDAQMARTRNRPLPKRTVTPLHAATYGALTGSVGLATLYAINPLSAFLGLFTIVLYCPLYTISKRHSVYNTWVGSVVGAIPPLIGWAACTASVDPISQPGAWALFGLMFAWQFPHFMSLAHTLRSSYASSGYRMLAVLDPPKNALVSLRYSLALLPLCSIGFPYLGLTTTAFAALSLIPNGVLAVAAWRFWKRREERRAKELFWASLVHLPVLVSLALVTKKSLWTSDAAAAEEEEKASQAAQDLQSPQRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6A6</accession>
    <name>A0A2S5B6A6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_4620</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6A6"/>
    <dbReference type="STRING" id="741276.A0A2S5B6A6"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY72318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="611" mass="65715" checksum="7CC25D9236932EE7" modified="2018-07-18" version="1">MSNSAPMELPRDVLKFQEGRWLTLSVSWPEAIDALNGLQSNAAVIDAIRKSGGKGGDVQLNEQLEYMKRIGYAPADLNRMNVLHITGTKGKGSTSAFVSSLLTTLAPNAKVGLYTSPHMVAVRERIRINGEPIPEDMFARYFWEVWDKLETDQQRADPVTPEKPAYFRYLTIMAMHVFLQEKVLWIGSARARENWFSRTRTSQVDATVLEVGVGGTYDSTNIVPQPITTGVTALGIDHIWVLGKTIPEIAHQKGGIYKPGVPALAIKQNEGLDVLESRAKELGASSFTVIPEHPQFKDIKLGLAGVHQRSNASLAVGLVQTFLASERCPPAFTLAKEAVSAPKPAPKPSADSALPTVPAELVAPNPLPAAYVSALEQTRWPGRCQLSTDPADSRVKWYLDGAHTVESLHCCGQWFADEALASGGPATRALIFNCTSGRSGLSLLGALTSSLSAGQSRVSAQPFEHVIFCTNTTYASGSSKGGELRRELLVRRSSSKLILIPPPLVVPRRRLPPPPPPFIPSEDLTSNAVDAKDLETLATQRELASAWDELVASMPSGSEGKTAKVHVLGSIEEAIDVVRQAAGEKDGEVQALVTGSLHLVGGVMAVADLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6D5</accession>
    <name>A0A2S5B6D5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000051">
        <property type="protein sequence ID" value="POY72271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6D5"/>
    <dbReference type="STRING" id="741276.A0A2S5B6D5"/>
    <dbReference type="OrthoDB" id="10261361at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="714"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1171" mass="130363" checksum="DDFB78F874E2C771" modified="2018-07-18" version="1" fragment="single">METRELAGNAPPRSTRKTRGSTRISALISRFEEAGDGQVDREGGSAGRAGRTNARENRSAGSARVQPDGDTALPKSTSSVSTSGATSVSTSTVDPQARSEASRVPLFSDPMRRPGRASGSYRDRWNSSDPFDDRFAALSPTLASQDSLLAELLAADARELAVDGPSADPAISTAPSPVTIPLHRVFARDAEPLVLPGLDDAIRALGGPASFSPMPTRSGLPSERFRGSIGRASLESTTASCVKGVGAAPEDEAEAEQRGWEAWVRDGPPRSRWSSFTAAVRRRVPGLAARATTSDRATGTDLSPEQHHRSLIFPPFHQLPPGVTVTDLKQNRRRSQPLLTLQSALGIVGNAILGAAGSNKGISLTTIEGIRDLMQLASLFSTSQETGSATPSALRTVFITVPAFLSLDFGTAFGRPLIFLLVLTLITLVGLYELMRFTGGRKGPAVGLRRDDGEGYDCEGGVPRHASWRNSRAYRLVITFWCTSVYLPLSKLAIGALVFTDDYWPVPNPYLDSDSPTLPSLGPSHYAPLNFCYRTDMRKDAPNFVWLILPVAGVVVLTLSIWLPWRLRSVIEHEKPHVDAFTELGEKRRNDRAEYQRLLEADPSLFSFLYRGASPSVALHFGSYRTLTHRSHVDFRRPWATFRSVYLVFKLCNVLLILLVQKNNCLFRRYPTVYLLVVRQGCLLAFLSLYSLFAMKTLPYLDIPSNSSDVCSRVGYSLLAMLGLFGALGLPGTDPATVFVNVVLYSLSASKLTLSYHYSAYFVIIGMSWAQRLVKRVQRRIDFSVDIFSPFLDVEKHVKRRVWQETLAAIFLCSPEFAMSPERKLSFKLEPTPYLLDFGGSTAERIVEDFKILRSVGLAEYRAALADYRALQKLRRVILHELTGPDRYYRPAELELVSTASFFGRLDVVPFPFLVLFRYDRGDTVRLRSREELESLIEQNQSAAVAEARRVRLSLRALEGHVVFAPHEISTRGTRTSYRLAVLRIDRNSARQWNGYNCSSGFEVQLDYADGERQGVGRLRSRLRYSRAGSSFGVDTSYQLTAPLAVLFRQNRHLIERELPRISAALSAHTAAFAEEVAAKEQSLRYSVLPDVFFDGRLEVLEKEPDIRVRLLRAEHVASLQRLQERTDWLANAAGRRWWYLLWDDLWRRNHSSLPALTDVDFSPHYSRSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6H3</accession>
    <name>A0A2S5B6H3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6H3"/>
    <dbReference type="STRING" id="741276.A0A2S5B6H3"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="378" mass="42696" checksum="9F69354C6746D453" modified="2018-07-18" version="1">MPRVALVQFASLSPSAPLPAAALDATQQHHDDRHQQQHAPSQFNLQRAHDYVKQAAKQGAELVVFPEYFLSGVVSEPEHWHLAQFPHTHAHLHRPSDSETATAQHWLSTFQHLAKDLRVDIVVGTIVERAVDAESGQPLSRQVEIESDQTGERRTETRPVLENVSTYIDWNGEIIGRYKKRNLWWPEKDYLCAGDEEHQVFDTRFGKVGILVCWDLAWPRAFEPLLLRGADMIIAPTYWTGTDGGPEGMKHNPTSETDFLQVLVKTRAWDNECAILFCNVGAPTSWSPGDPFGNEEGRIGCSQVCVPFKGAIASALLSLQRITDHEHRKPEQKGPQEELVLADLDLSILEDARKVYGMRRDLITKLREEGKLPDWVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6H8</accession>
    <name>A0A2S5B6H8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6H8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6H8"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="722" mass="78102" checksum="A285D87DC1EFEF15" modified="2018-07-18" version="1">MPFLRRLLSRNNGGTATNDDGGRPHDEPPTYEPSNGAHVAPDYVADEDDAPPPAFDFPTSYSVGHHPNRESSGTLFIIRSDVQAHVRLLAAFERLRQKVEAGCAGIAADLDPKSRWSLFVNVAVHRLEMFLRIMSMMSNEGHMEQVLPPLDVAMALHAYMLQPLHALTERDHQPDTRGSGQTVCGRQAAGRTASVWDQADSAVRRREFLPLRANPASSSLTDTETQAFAINGSTFELPASPAMQSVWSDLTNTPYDPLEYFATAETRTTPEIHGFPSIEVPWITPEKTGYAQEGFKAKSPDGLIYTHATLGIAKLASDVYRCKDDPLATLACVIAGPEAVLSRNGQLLTSPDHSGTVVSPWLLPEQPAGAPGARWVATRMARTLEIRHSDNPQDLATAYKWDRDTVEKTFLATLGMYKQGGINGILNCYIRGEPFSVDLVPLILREADFTRDLSKLGWFTPGKLDEDTATLDRIIARYHGFMDVVAANPPLTCIPTVDIELAWQTHLLKPTYLSDVHSEVGRLVDHDPAIEESALARLFDETSDAWTAKLAISALRSHIRGSASTADAPTRAEYSARGYPDNSATHPSELVCVTLANKSDALRERQKRHKVAQARKKEAESGAVPPCALAGVTGGAYLKPNLQSVCYGTSGYALSEEDGFVICARLADPATVLGGEGYGPHAVPGRAMSVAAFRAQAGAPSSLVWEGLAINAMGVGAGGFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6T8</accession>
    <name>A0A2S5B6T8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6T8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6T8"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015677269" evidence="10">
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            <begin position="21"/>
            <end position="461"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="461" mass="48154" checksum="8F3FC6516AECD89A" modified="2018-07-18" version="1">MLGTIKLLTVLVASVASVHAQSRVDGSLSLGPSGQGSCTVSATRPDQFACANGATCRWQADDLAFSCSFGTGADGSTVAGADASSGPPGRQCVAHVGHWDCDDGSLCEIQDGVWLCESFSSSEHGDGESGASGSCNGLDLGAYDVNLHIVALFVVLIGSTLGVLLPIVCSSVLNGRVFRGVFFATKHFGTGILICTAFVHLLYHAFIMFSNACLGELAFEPAAAAISLAGVYVVFSVDFFVMRWLRSRGEHRSAALAVLHADDPSRSPSPTGEKSRGDSTCDLGHSHGPARELPTDYSSTQAHFDVLILEAGIIFHSIMIGVSLGASGGDQWIPLFIAIVFHQLFEGLALGSRIGQLVWRTGQAWKKWAMAVAFALITPLGIAIGMGVHASYNPNSGASLLSIGILDSISAGILIYGGIVECLYHDFMHGSLARAGLGRVLLALFFVLAGSLCMAVLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B741</accession>
    <name>A0A2S5B741_9BASI</name>
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        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">BMF94_4416</name>
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        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
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        </reaction>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="232"/>
            <end position="406"/>
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    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="423" mass="45116" checksum="C30C3257367128DE" modified="2018-07-18" version="1">MSTPQKQQSDGPFRRLVRSLSRSSPRSERPALPSPPALPNNGSKRYDASGTTPKRESPPSSAALSTSPPPDSYFPPPPSAVLRDNEASGRERHPDTIGARALDAGERGKEAAPGVFFAPAGPDAEQRKRADSSETDGWRPPMPRRTTSQRVRRNPSSAEAPMPNGAGTGSAPTNGTVTIGDRTIAAGERQGVSLEDKPLTRQTSTGLKRTASQWKRAAQKAFEPMPKQTGDKRVLLMVADGSEEIETLAAYDIFVRASLAPVLCSVSPQFSPSHSLPHITLSRGARVLADAQFENMKQEYKDAYFDAVVVPGGAKGAERLSKDPGVQALLRQYYESQRLVGCICAGSLAAKSAGIGLGGPITSHPSVKGDLEKHYQYSEDRVVVAGNLVTSRGPGTAIEFALQIVEILAGKEKRDEVAGPMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B770</accession>
    <name>A0A2S5B770_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B770"/>
    <dbReference type="STRING" id="741276.A0A2S5B770"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="101"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="204" mass="22474" checksum="4C16E340EFCF61D3" modified="2018-07-18" version="1">MSAFNKLPAVLPQLAYPYNALEPAISGAIMELHHSKHHQAYVTNLNKAQEDFAAATQAQDIKKQIALQAALKFNGGGHINHTLFWENLAPTSAEGGKFPSSGKLYDQVQQDFGGLDGLKKAVNTAALGIQGSGWAWLGYNPQTKKLETVTTANQDPLLGYVPIVGIDMWEHAYYLDYKNVKATYLDNIWSVVNWKKAEERLTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B777</accession>
    <name>A0A2S5B777_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B777"/>
    <dbReference type="STRING" id="741276.A0A2S5B777"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="684"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="929"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="716"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="955" mass="104045" checksum="D4C3759CD9DD58CF" modified="2018-07-18" version="1">MDLAVRSGSEGSPRSEQQSRDAAHDSTSSKAKNQAMNRMGRACDNCRRRKIRCDAVGGPNGTESALAEQPCSLCTTQNVPCHFEFRAPKRAPNKNYVESLEKRLEAMEGLLSSLSEPGAPAPNRPPSGIPPVPRAPPTTTTPGWQTPAQKRSSASGPPPLSSGHSPQSISTSPEPVATDLDAIQRLSDRLDDLVVEHDRYVGRETGLHLLQSVNQHFAIEVPPVTETDLPLVDSLIDNLHQTLQFTTSEVAPDLAPRLIDAYYTFGTWGFTILPRPYFEECLEKGLLSTDRSFRSLYYAMCAVGARFVDDHRLVPKHPVANARPNQLQMAKGFDLYWTSLVYSKMPVSAPTLFDLMQSVIALTWLIGSTGFITAWTMVGIASKAVDVGIHREVRSRWAHSPVEDQSRRRLFHVLLTLDQWISSGIGRPTALNKEDTDVALPLEISDEDLWKWELETRRTRQQALPPPPPPQIDPSTVIYGLQAITSLFGILESARKLFYPVKREPVTDQAISANLRQIDTALNNWLAYLPLCLQWNPTHQDDMALCGSAFVACHYFFAQIYIHRDFLSPSRSHAIGYPSLEIATNAARACSRILDVLRHRDCLKQSYTWVPLIAVQSGMMLLLSVFANPPGPAGSARMTLTPSAAADVKRCLIALEYFSDKTYMAKKCHEGLLKLAAMVAAPPTSSRSAAPSYPDPMRSSLKRCGQDDWTDGRSPADSTRGSGSDKQSPVDSNSYAAFAEQSHKARRTDTSSNHLPFTTEDLSSQTFNGRPTFLFDQTTAPSVSTVQQTVPISIAQTLSGPGGSHTVMPNGTLSLPEMSVAAPKTPLPTSTPLPPDYNLPHVTPTLANPTANGFDFQVPPGSPDLLSALYSTGGAYDSSSFWQLAMDDPLAVPQTVEQVASDMMFQLGDGAGGFYPAAGAQDSWTMPFDTSPTSEGGRGSFDASLFNGLPPFSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7K1</accession>
    <name>A0A2S5B7K1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7K1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="938"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110689" checksum="21411D8D236CDE3B" modified="2018-07-18" version="1">MALSCERAAAPVDFHPPSAAPLSPSRQSPILDDCGADDTLSDSDDARAYADAVRSDHSGSKVPRLRRTRSDSDLGKVVLSPAAAYAGHVQLRRRRDTLTQPIRSTGYEENDGAAETRPTALHSVDGAESDLPILPFRSSTTQLGPGATNKRAIEDVISETAAWRDVELARGSEIAGEAATEARRRRRSASVESKASSVPSNEKAADTSPYPEVRASVPGDDDPDALVLTLRVWLIGLAFCAVVSAVNAYWGAQFPAPVVTPLVTQILAYPIGLAFAKYLPGWTYSPPTWARYCGIPRKLSLNPGPFSRKELTLLTMMANISTAAPWAYGFTFTAEQGYDRHVSFGFEILFVLSSQTLGYGIAGLTRRFLVWPASMIWPQTLVYCAVLGSMTDSARKGWHQATQLRFFAVALMGAFCWYWFPGFLFSALSAFSWICWIAPDNVVINQLFGVSSGLGMGIFTFDWVQIAAVYEPLVSPWWSQVNFAGGFVLLFWIVTPILYYTNTWDTAYLSINSKSVYDRFGEPYNTTRILYDEHMRLNATAYAEYSPVFLPITFLVTYTGQFALAAALLVHTALYHGPELVRRFRRPFAPRIDDDVHINLMRTYPDVPDWWYGALLAITLGLAMTTVALPAPFKAFPVIMPPWALLAAFAVACLYFVPSGIISATSAFTASPPRTAEQPRRLLSQRFDGANRRLSSSRQPGSEYGTNARSIPVPPDVASDWRAFLQLFKVYTLQLGNQGIYYSQGLKLAHYQKVPPRATFSGSLLRGAPRGLRLTRRPATVQVVATAMTSFVQVGVRRWLMARNASPCARDQNGGLDCPMIQTWFSTSTFWCVRVPGERFHSMLLYALFAGALAPVPLWIIARRWPGRWTSWVNLPLFLTSTVSVPPATGINFLAPLIVGFIFRAFAPLSTSSISLRDVSAEYYLRAKKTRWWARHNYLLSAGLDTGTAICGIVMYLTLQLPKSGSLSLDWWGNTVYTKTADWLGTPYKTPPPEGFGPRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Y6</accession>
    <name>A0A2S5B7Y6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4054</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Y6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7Y6"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="116"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="213"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="305" mass="32888" checksum="CFAB5E9F41C75831" modified="2018-07-18" version="1">MTKEGKKNEKPQLALVAGAFAGAVEGFTTYPFEYLKTQTQFAHRTTGKASRPRFVKLPPGLWSITKTTYARHGIPGFYSGVGALVAGNSLKAGVRFLSYDSFKQMLVDKDGKLSGPRSLLAGLGAGMMEALFAVTPSETIKTKLIDDQKRPVPRYNGLVHGTVQIVKEEGLSGIYRGLGPVAARQGANSAVRFTTYGTLKSFVSGNSRPGETLPAGITFAIGAVAGIVTVYATMPLDVIKTRMQSLEARTQYRNSFHCAARIFSEEGITRFWRGATPRLARLVLSGGIVFTVYEKVIILLGGRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B879</accession>
    <name>A0A2S5B879_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B879"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="229" mass="26079" checksum="072196D17173A17D" modified="2018-07-18" version="1">MEDYPDPRSRAYAADPRGNAHLATDGTVQKVLNDIAKAVQALLARSNENLETQRAIMTAYEEWRGGLLQLFARKPGARVENGWGVWAGYCVKVELQKLLEALELRVVLENPRIAVNRLDPLNHLNRTIHETITSADRSLKNARLNHSPDIPEYLSIPEVHLVTREGRANEGPHIKEEPPAEEDPHPRIKRESPVVNLHLIPLHPSQLHSMGRHALLNRFSLRQQRLYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B887</accession>
    <name>A0A2S5B887_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3972</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B887"/>
    <dbReference type="STRING" id="741276.A0A2S5B887"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="54"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="412" mass="46463" checksum="344D15BC3F131B1D" modified="2018-07-18" version="1">MGCGQSIDAEASKNQQQSKAIDEELKKAKAEEAAEYVASVYRRTVKALMLGAGESGKSTIVKQMRLMYAEPYTSEERHLYKDIVYSNALQSMQVRDSVFRRPEARADTGRKPRQAVVSGFEHINLELPLDLRPAAEYLPSISTEHVADRRTGDMLPEIRDAIIALWADGSTRRVVGMSSRFQLNDSAEYPPERVGRSSEGRRQTGWTFSTFFDAMPRVGAPGYLPTDQDILRTRVRSTGIVEHAFDVRGQKLRVLDVGGQRSERKKWIHCFENVNMLIFVAAISEYDQVLFEDSTVNRLAEATMLWESVANSRWFERSSFVLMLNKIDIFAAKVRSGESPLVEYFPDFTGPPGDLDAAKQYMKHNFVSLSRKKDRGLYVHLTCATDTDQTRVVVGAVMDQVLTRLLSEVGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8N2</accession>
    <name>A0A2S5B8N2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8N2"/>
    <dbReference type="STRING" id="741276.A0A2S5B8N2"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
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        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="148"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="259"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="339"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="339" mass="37596" checksum="EE8C3F6F991B04B4" modified="2018-07-18" version="1">MAEPITFSSRLPGDAHASPSPSSSPSPAPPEPEPEPEASSSTAAPALQQPNKTARTIVLTSISPNDPAKRRDFEARYYSPPSSSSAASTASTRSFLDLPESYFTPTASELQRAHAQAISHREHLVDRPLLTSKLRQRQEAERNRTKAAKWPQTRIRVRFADRSLLEGVLPSTDKLVHLYEFVRLALDPKVRHVPFVLYQSPPRTEYRKSDPAFRGKTLMDLQFTPSTSLYIKFEAPVTPPTRTSSSSSTSPPAEASVPPVDLDALNFATRDDNQQWRPPLIHDLLDAVAELPLPPSFDPREPEQSTPGDDKGKGKAVDEAQKKKDKEDRLRRLLGGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8V5</accession>
    <name>A0A2S5B8V5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8V5"/>
    <dbReference type="OrthoDB" id="5588482at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015521535" description="DUF7729 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="71"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="444" mass="43921" checksum="956DBD5D45A63744" modified="2018-07-18" version="1">MPSLSTAWTVAVAALAVTAPRALAQDASAVSPSQASAAPSASQSASSTTSQAATPAATGTASNPLIPASVSSQCQAFLTDLNSNDAIAACTAPLLTTVNSFHASSASASATTFSSSSSQIQSALNDLCSAPACDDGLVRALLGQFNGNCSAELQSSNQVVLGSYDALYVLSPLRNAVCSRDDSGGFCVDDIASRSMPTTSTGTNATSVVASVAASNSAAAASSASAVPSAAVVGDATNSTVPALKSNFAILAATSDAGADYSIPVPAPPSLYVQITKVARRLLRRQWASGSGGVAPASATSTGVPAAAASPVGISDAGVHAFDVPSILPDAQTWSASNLPFLFLSPNMSSSVLCSSCTKTILSSYVAWESRMPYALGLANSPLLSGQGNLWTGLGQVCGSGFLQAVTQQAGETNLAGGALSSVSRVGAATIVGLASVVAFTLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8X0</accession>
    <name>A0A2S5B8X0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8X0"/>
    <dbReference type="STRING" id="741276.A0A2S5B8X0"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="513" mass="54378" checksum="ADCDD24FE82E4D74" modified="2018-07-18" version="1">MSSTMTTTLPNSIAPGRPPTSTAAARQLYQQATRAFLVRDYPTAATCLHDGSKHVEAVRPDAWFAALQSNSHAVPANVEVRRRLDILKVTLIATVRSSPASLSPAPQWTSLLELDPDQLVGALWSDLIGAGATTSSAGKPGDIVPTPAAAHLHPSLAVSLALAALKLEAPKAARAVAEAWFGSVSEEVEILAADYATSGQVDWQSGDEFPLDQVAGGSSSGARTAPGLSASSTLGTASPAGRSDSPVVRALVASWLKLLDLLVFHILPKLGEWDAAGDFVRLQSQENGGWVPDVRVEASLRYLKDLQQEEVHLAAARIQRQKDLEIARAEKKKQASAPSSRRGSDKGKQRADQTERGQSPASCASPRRNGARGSKSPSPSENKTRSPRADGSPPPPAGFAGLRDSLSTYLQRPDASAFGTSAATTRDAAARQGRQKTSPVGALVSYVRYHYATDPIRLVSFVCFVLALITWTRRRLTLRRSRGERGLGVGDALRIAASRVAQTVGMATKITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B955</accession>
    <name>A0A2S5B955_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_3645</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B955"/>
    <dbReference type="STRING" id="741276.A0A2S5B955"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="179"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="295" mass="32130" checksum="949E65091A3111E9" modified="2018-07-18" version="1">MEAIARPPPPPRSYTETVQDDIEAATSSSFLLEPTRPRQTTGSTSAASAEYGLPAQRQTAVVVRLRETHDDHVGRPTTSLPFARSSSTATLRLPSATDETTGREAGGGGHAGLVRASSSATLLVRDDEDSDQDSDDSLGSDNESFRFRPPSVASTSPSQRSSRIGVRLEDWSDRPNAAFVRDVKIAGYHTVGADSSGFVVFDIELQTLPTAAQPQGTVMKIHKRYSAFVQLRRDLLAAHPQFRGLLPRLPPKSSLAKYRPSFLEKRRQRLGYWLATVLLHPIVGGTAVVRGWVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9A0</accession>
    <name>A0A2S5B9A0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_3687</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9A0"/>
    <dbReference type="STRING" id="741276.A0A2S5B9A0"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="17">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="16">
        <location>
            <begin position="155"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY73352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="458" mass="51551" checksum="5ED89EAE3E8AE890" modified="2018-07-18" version="1">MLRPLGRSATTTPRVVEHGPRRVTVELPGGDRTSFSYVWLRDHCREERSYHPQTRQRLVDTTKIPADYRATQVEARGDGPASDFESAYESFFPWAFLIEHAYNPTLVRRDQLPASNDELSTSSFLVSPELFFDNAKGAECSKMYWTKEIANDPPTVAYDQVMTSEEGVWEWLKRIDTYGFSLVSAIPGTPEATEALTRRIAFIRETHYGGFWDFTANLEHGDLAYSDVRLEAHTDTTYFTDPCGLQLFHLLSPSTTHTGGHNLLVDGFRAAKVLEESHPDHHELLSTLPIPAHASGSGSASLPSGVHMRPVRNLPVLNHDENGELVMVRWNGDDRGVVGGAAYEGEKMDRWYDALRVWEDILRSDEAQLWTKMEVGTAVIFDNLRVLHGRSAYSGSRRLCGAYVNGDDYRSRLRGLRRQFGGGDPKLSALRRLVNERYSLQAALDSAPQRTGAWADYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9A7</accession>
    <name>A0A2S5B9A7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9A7"/>
    <dbReference type="STRING" id="741276.A0A2S5B9A7"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF15">
        <property type="entry name" value="VELVET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="174"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="391" mass="41829" checksum="877A98BACE36A5F6" modified="2018-07-18" version="1">MSQTPPEESGAGAPSRDRQDLIAQPLPAVADVPQVAAYLGERESESAMAPRSSRSRDQHTGDEPGSGTGLAPSSAASLGVAGGRQPTVSQTRRVSRRASTNPYASESRGAGRREDHEADSGLPVAGPSRPATEAARTNPSNTLPSNLSLSIPDGEGAIGGSVPLERQRSSASTGNSARHFELSMLQQPRVGAELGLVRNTLGRLPLVPAPIVEVSVRNETGERTDTELPFLFCSALLREADGTSPVEVVRPPESAGAVHRSSTAQGEEEWSALVGQLVRNPRRVEDTDGQQRSVFVFEDVSVRERGTYRLEFMLGEARRPSSPRLAAVVSDPFEVVAWEDYPGIPREEIVPELSMHLHEQGIPIWMPPLHTTRADDGRPRTADEAPQSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9E9</accession>
    <name>A0A2S5B9E9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9E9"/>
    <dbReference type="STRING" id="741276.A0A2S5B9E9"/>
    <dbReference type="OrthoDB" id="2535935at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="821" mass="89446" checksum="AC07C5B660CABA68" modified="2018-07-18" version="1">MRLSRCFPPATRPPDPLAGVLSTPAHHHWRQPTPTRARPEPRYGPVERQEVPLAVSRARQTVQWQWQPQPVASTSKSTLDSPAIPRVHDDAVEDAEREFRDVLDALPATDQSVRVKHRNTADVRTDVALSRRACFAAYSALAKLRQVKAHAVSPNRNNPTNDSGKGKGPLRNEKWIPLDLERKVARLVGETMRLLLRLGHVHAATDLDRAFFTSRNQSRSERRRRAAAPRGGDAGGEKRGRDQATKDCRDDRDGGRLGDGLGLRRSAHQLAWMQAVSAGLELQELDGHGRASASPGQVTGAGRRFLENLEGLLVEGRDAVPSSGSTSAPLVRADKLAFAARQMGRVQRSIRSATPPSSRPGPLPAFQAELATWVAAIRRAECEDADELVSIALLESGLERLEQAAARRRSHSGRDCTEVALLHKVEEDINRLVRSLEQDGAGGASLARRREASRHAHILALAIRFLLFRQQHSSSTTLRAASSPSTDTLLPAAQLYAVLLKLPLPPVSTPALVADIRARQTSSLFRLLDAYLDAQAHSHPKGPRAFRSVERILDLLDLTLGRFEAYGRSHGAKSQREGIALGVSTKTYQRILRVLSEPSRLRRTSPTLSRSNPATDLSPPFAFLSRALDTIARARAHDGISRTGVAVSTSSGQAVFAHPKTTIHFVRAWFAAPLSASTPSPLALDISTGSSLDCRPREDGSEIQYRLRSLLAFVDAIDAVHTPGPASLAEDKDGPGAAAARRPSCATLRSRKVVVRAVREIVEQRWGTVGPHRRSRDAGERGEDVAECANDQIGGQPASWTEAVVEGTLERWLAPVEADSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9R6</accession>
    <name>A0A2S5B9R6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9R6"/>
    <dbReference type="STRING" id="741276.A0A2S5B9R6"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase-like" evidence="2">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="254" mass="27581" checksum="5F76F584355B9C6C" modified="2018-07-18" version="1">MTSPHVTVRHGTHTIEPGGPTLSYSLHQPNSARTDDARAAIIAHPYGRLGGCKEDHVVVAIVDALAGRGYTVLRYDARGSGSSTGSVSWTGAAEADDYRKMLDEVLLPAVLPNPDGSTPPQFTVVLAGYSYGSLAASACPPPEAPRDMPQLRVETSYLLVSYPLSVLWALCAFQAGKFSSALRTRVGGDQGEKVMAIFGDGDQFTGVDRYRTWVADLSNERFHAVEVKGADHFWRDRRVKGELLEQVLQWLHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9U6</accession>
    <name>A0A2S5B9U6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">chitin deacetylase</fullName>
            <ecNumber evidence="9">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_3480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9U6"/>
    <dbReference type="STRING" id="741276.A0A2S5B9U6"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF135">
        <property type="entry name" value="CHITIN DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015646299" description="chitin deacetylase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="12">
        <location>
            <begin position="97"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="292" mass="31426" checksum="BF0B160F973278F5" modified="2018-07-18" version="1">MLSLLLALLTGSAASVPLFERQATAYPDGSKAGPAPKPEWLRSLNASKLAGQIPAIPPSTVSNGNIVYPSGVDLQSICSWTLTGCFGPHDIQEAPDGMYGVSFDDGPLADSPLLYDFLKNNNQTATHFFVGNAVRDNPQIASQAFANGQHIGVHTYTHPYMTTLSDAQVLGELGWTMQIIHDLSGGYVPRFWRPPYGDADNRVRAIAENVFGLTLVGWNQDSDDWCLNDSGGSSCGSEGPSNLAALESEISRWINSSSSPGIIGLEHELSAQAINAFINTYPKLDSQRWDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9X9</accession>
    <name>A0A2S5B9X9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9X9"/>
    <dbReference type="STRING" id="741276.A0A2S5B9X9"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01119">
        <property type="entry name" value="COPPER_FIST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="594" mass="61091" checksum="D18C837A3416661F" modified="2018-07-18" version="1">MVLVDGVKYACQQCIKGHRSSKCTHSTRPLVEIRKKGRPSTQCSHCKDLRKTKAVHARCDCAARDDKRKHLFSAYTRARDHVARVLPNGIADVVKSPDPEGADLTRTEPSGVTLLLNPCNCLRGGKCTCCESNKKPTAKFFPAEKSVATVVAADSSRQAPAPSCCTSQELQSSQSRGIQYDPTGDIVVSPDPTAASPVASTSSSSPSAPINASLCVIPMRSTPSTEAGTYAGLPSHFAALSTTQSWSTPSSAGPASPAFLPTPPLFLPPTAGTLACFCGPTCQCVGCATHDPYSRKRPAPGACSGGGCHCGTGKGCEEGKIASKKSKVEVGPAPSTKGGCCGSKKPAAVEHPAASSCCGSRRTSPSESVSSLLDGPPPGSAGISLPSLRSPGALPADPLNPLSLASSSTPPVGPPTSAPLPSLRTLWPALLDVDASFATPGGAGEAHISTSATPELLHGDDADNDALSGLPAGLFDPSREPAILRNPLDAAESATGGNWTPGGASAPPLARNDKLVLTACSACFLEEPLDDVCGPDEDSDDEEDEEDEDADEGGARDGDRKEADDQAGCECTSACACRQIAKERRRSRELEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9Y0</accession>
    <name>A0A2S5B9Y0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9Y0"/>
    <dbReference type="STRING" id="741276.A0A2S5B9Y0"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="311" mass="35223" checksum="1398118833C6D640" modified="2018-07-18" version="1">MLRSAASTILRSSPRVRATTPSSSWCTASPLRSQLSRQPRFAVVRHAATSSTGGGSQTTRDKLRARPYLLLVGIMPVFTFFLGVWQIKRLQWKVDLIDQLDQKLHQPPVRLPAKIDTSAIPEYAWRKVYVTGELDHEHSVELGPKTRDGQLGYHVFTPLKRGEGQDTILVNRGFVKREHRDPKDRPASLTTGPVSLVGMLRSQEARNSFTPVNQPDKGEWVFSDIEELARYTGSEPVLVDQIYEDNPGKVELFLREGVPVGRNAAIELRNMHATYAATWFTLSAFTGFMFFRLMRRPTVVTTSQYRKLKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9Z9</accession>
    <name>A0A2S5B9Z9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9Z9"/>
    <dbReference type="STRING" id="741276.A0A2S5B9Z9"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="21"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="359" mass="38685" checksum="590A6DD505D4819F" modified="2018-07-18" version="1">MSSSIPEQFTGYAALDEARGKKFEVERWSYTPKKWSENDVDIKIECCGICGSDCHTITNGWPSPTSYPAIVGHEIIGTVVRAGSNTTHKVGDRVGVGAQGACCQECDFCQKGLESQCAKGMIGTYQGRFPDDGSIAQGGYAEYTRQQGKLAVKLPEHLDSAEAAPLMCAGVTVFAPLKRHGCGPGKKVGVIGIGGLGHLALQIASAMGAEVYALSHSDSKKADAEKLGCPPENFIIAKDVKETAKKYNKHFDILINTSSGADMPLETLYFPLLNNLGALILCGLPEDKLPAFYCQQLVGKSLTLAGSLIGGTSEIKELFELADKHNIRAWIEKRPMAEAQKALEDMEAGKSRYRYVLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA07</accession>
    <name>A0A2S5BA07_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Uracil catabolism protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA07"/>
    <dbReference type="STRING" id="741276.A0A2S5BA07"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49602" checksum="D5CB641397052508" modified="2018-07-18" version="1">MSASSSSGSSNADKIAYLRSLPSIRERCQRVFDLAQQDKLDYWTLDLSQQDKIVDFVCKLIERDYGTDYDSIPPHGRWRHFVGNRVDPILAAWEEEKVAPLEKARRLVDLMVVSVLMDAGAGNEWKYAPKEGGEKIARSEGLAVGSLEMFEKGLFSGVEGQPYRVDAVGLSKITPEDISTAMQVSEANPMAGIDGRAQLLVRLASVLTDADNAKYFTQAGASRPGNLVDYLFSHPSSQSVPSPVLGTKIAVKMETMWDIVISGLSGVWPAARTKIDGVSLGDVWPVECLEKQGSKDGDELVSFHKLSQWLTYSLIEVMEKLLNWSFIGKEQMTGLPEYRNGGLLIDHGLLVPNIPAMLTSFSQPVPSAASEYPILLELPPFPASHSAMVEMRAVTICMLDRLRDGINAKLGVELSLPQVLEGATWKGGREIAKQLRPATGGPPFQYVATGDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA61</accession>
    <name>A0A2S5BA61_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA61"/>
    <dbReference type="STRING" id="741276.A0A2S5BA61"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="99"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="598"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="664" mass="73001" checksum="DBD3CE22F247BFB2" modified="2018-07-18" version="1">MAGYTYDTSGQVYFFVLTGLLVFLLPFTYATLLGGAERAAARVRAPCTGWNRKSNEVKRAGGQKRLFSVKSVVLALGWLAFAVVVQRARGIQGEGPQFDPFAILGVSSSSTEKQIKKHYRKLSLKFHPDKVSYADDAAKEEADSHFVELTKAYKALTDEVSRRNYELYGHPDGKQEFSAGIALPAWIVEGKNSPLVIGAYALLLGVVLPVLVGRWWYGTRKLTKDGVLNSTAAKYFHALKEETTFPQLLDILASSDEFAVDPTLVKLRKSHSKTATDEYARLVSTVREGVDGQKGWEGYGTWSPAKKRARVFIAAYLLRLPISDVGLLKEKYQTAAIALPLCSGLASIALAHNWLSTYIAIVRLQQFLLQAVHPTSSQLLQLPHINPELVARAEQQKGAKTVKEFGALPANEVEKILEGMRESEKRDVYEVAKHWPIVQFVDAKFEVTGERIVTPGAVVSFTLKLRLAPPGQTNEAPAAVDALHEVENAEGAEKSVEELIGRSRADEGVVPTPLAHAPHFPKNRKPAWYIFVGDHKLNRVFVAPHRFTDIGEGTTRTVRMTFQAPPGPGLYTFQVYVMCDSFVGADAQKDMRMLVEAPKEGDDVSDLEDDISEPDEDSLAGQMALMKGQPVRRQDGPDDEGSEDESGTDSETESSSSDSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA63</accession>
    <name>A0A2S5BA63_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA63"/>
    <dbReference type="STRING" id="741276.A0A2S5BA63"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="453" mass="48868" checksum="B91F0011B04D37DC" modified="2018-07-18" version="1">MATRGNRHTRSGPAGEVGKITVLANMERADEAQALLRKIHAMAKPVMKLHGWFLPTLAEFFPDQTNLLGVNYNAGQRICIRLRPHYDSNSFLSLEDSLIPTMLHELTHNHRGPHDRIFDTFLKKLTDDLTGYRMKGFFGFSGQGFRLGAGAVPPRLGLDMRKARIRRIEYLQKQKAVLGRGGRLGGSGPEKFSRAAAAERRRIANKAAERRRNATLGCGGDKKHPGGSDRQHQKPDIVAEVDRAARESIVIDLTGESDNVSGSAGGPVQKSSTKRRRRQASASSSAVAPAPSERKGTRKPAQASFPVPSRAPKVIVIDDDDGSDDDIQIVSMKAAKASNKPKVIPPSRRSTAATPGANGSRSRSSTIGKTAAQPPIIPTTWACPKCTLLNSAEVSSCQACDVKLAPVHANKASMYLFAAEGWVCESAGCLTLNEQTRWSCATCLTVKTSSAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAH0</accession>
    <name>A0A2S5BAH0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BAH0"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1384"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1208"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="888"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="816"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1217"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1543" mass="166820" checksum="8F7654D2C62D0150" modified="2018-07-18" version="1">MAAFANGFQEDDDPLPVVVVPEPARVDEAASSSSPRRRRSTPPAKVDSNGNGSAESGAPVDTLDLTEDSPEPENGCGGGESMPGDDRRGGNRRPPHDLGRVGSAAGSPFRQNTLGFANAAAGQPGGVGGSSHSPSRTPSGTTASGPSGGFGQYASLSAGRSSSREARNDGAAGLSRRGSSSHDPGAGPSVNSFRQIPVISSAAAARIPSAQLPVASTSSHAAGPPSGGFMQPVSSPAAAAALLAGGTGFSTAKILQATQSAFDANKPLAQRIPGPPASPAGAAAAAAAIKRESNKGKGRADFVDLTADDGVSDDDEIVIDETPVCIGEVHTFGLVLDVVDEVLPPPSVPPTRPDGSPWPFDELEQMHRTHKQQVKAYSHPLPVYIFRDEQALFSGSTREMLRLITPNTHRKFAFIDYKVANVIGPLLSNGYHGDGPHFKEGGKLACVAEIDRRGEPNPALMKLRLLLFARPFDVPGIARTLETAHPPIWLEHPVSYNSAEWGGARYQNPHNPAPGVGSRGADAERRRQALVSGVYGGSSIGAQKVAKAVDVQKQQVEEVFMNLKSGIDLEEVTPPPIVSTTLYPHQKQALSFLLDREAVVEIPEKDEKGKPPAMVSLWQRKSDAYGQVRGWTNTVTDLEIAGPTPPPQARGAILADDMGLGKTIVVISLVCTTLDEARKWAKEAPSKDRLDSRLEDNVKEGRPVQASDFTTRMGTLEGDYGASSSKPLSKKKQAKQRREKAKEEAVQLRFEKLVCRSRATLIVCPLSTVQNWESQFEEHTTAVDVDPQGGKSIAVDARSAVGKALKRKMRIADSDEEGDYVVADQADEDSDDISDSSMKSEPSSKKSALKIYIYHGASRCEDPKRLADHDVVITTFSTLGTEFSKQCRADEEREDEEALAAQRAAEEEDGIVEVFGFGPNGEILTSPPGQADAEKAAKAKAEKEKKAKRKRKRVEGSGVSPLQAIQWFRVVLDEAHIIKEHRTIQARAACDLSTSRRICLTGTPLQNSLNDIFSLLCFIRLEPFLDRHVWTQYVGALAQKGEPLGAERLKVIMRHLALRRTKDTKDANGKPILALPPIDNKLLHLDFSESERAFYRNHHTRYKHDFAKLEETDSVMKNFCSILQELLKLRQICVHPALLQDSQDRAAAAGEGGGDLVATIEKHGISKSRAIQLLQLILEAGGGGCLECGHQMAAFARAEGADDQIDEDAAGANAGKPGRKPAKKARKATKLQSVPTSAATSDDDTAAATSEDDVPYIVTRCQHTFCPQCFRQHMCATWPLVKSDDKSQCRVCQAEFQPAVDAVEVHAREYAKALAQSSEQQANKGKGKGKKAATRLFEHSTKTRHLMGDLLPFSMVNPYSANYDPAFDPAANLEKTGGTVGFQPVPGEIVKSVVFSQWTTLLDRLGDALDEQHIVYHRLDGSMNRDQRSAAMEAFKSDPRCEVLLVSLRAGGVGLNLTAGRRVYLMEPFWNPAVENQAVDRIYRLGQTKSVQTIRYVMDKTIETNMLKVQQRKKELAQMSVGRTLSKLELAKQRQQEIAILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAR2</accession>
    <name>A0A2S5BAR2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAR2"/>
    <dbReference type="STRING" id="741276.A0A2S5BAR2"/>
    <dbReference type="OrthoDB" id="2523316at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="262" mass="29377" checksum="FA71E96DF53BD798" modified="2018-07-18" version="1">MLPQPDTQASAEASTSRAPRTGPPPRSHRRKDGQPPRPPNAWICYRAERSHALRLQPEYAPKIVARLWREETPEVRRRYELEAQELKRQHREKYPNYTYSRRTREPSAKVAKKEARDTTSESSGGPSTSPPTRESSNQATLPVPPPDGTLPRPPPAAAGPHPAPAFLLTPRNSVFPQAAYADFQAWDPASRMPVPRHRAVGLNEPSPAYPYHLPQAPYEQLPIPPRAPPPAPPPYHLGPAPLWHHGVAQEPHTELPWGYVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAX4</accession>
    <name>A0A2S5BAX4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000032">
        <property type="protein sequence ID" value="POY73926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAX4"/>
    <dbReference type="STRING" id="741276.A0A2S5BAX4"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="91"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="482"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="818" mass="91552" checksum="B09F95BE3CE780F7" modified="2018-07-18" version="1">MPTSTMPAPASRMPDSSSLSKSKQRAVPNFFKPSEEGLVRTVPPSGLASSESARKSSGLPMAQVLARHRTQPLGSDCDSALLPPLDEATLLRDVLFILQGLDGQYIRFRPDRPPNPGFRRTFVRGDIVLDGGAVTEEVDEAGSAVPAAYVGGIDFLLGDSGHSISGPTRALVHTLSELGWLYRTIDRRLRNESEQDEDEAREATQAGRSGAGRKRQGGPRRGMVEQSLHAELLQETTEYFKLVSSLETRLEGVDEDGTSAAVTANDETLSSQLTLRKLEVWTRDVRLRLRLMGALAADIGPGNCGGAFLSTLHAFTSNGDPFLSAFSSRLLQTLSVPFFGILSRWIYTGELHDPYGEFFVALNPALDEATRQPKNAADTYGDRSVEAGIPSHELWAQKYVFRQEMLPTFLDESFGRKIFSTGKSLNFMKYSCDDDSWVTLRGGKETPALHYTDMRELERSIALAYAEASARLFELFFDRFRLLDHLRALKDFVMLGKGDFVEILMEQLGPSLNRPANTLYRHNLTSTLETAIRGSTQATDALDNILGRLDARMLDFEQGQVGWDVFLLEYKVDAPISTVIDPSSLDGYRSMFKHLWEIKRVEYALNECWRTLLTKTRLLKGGSALAFALHQTRIALGDMIFFVRQVEYYCHLEVVACQWKELEDFVAKKDGDLDKLIAAHRRYITTLVDKALLRASGRRKKEVKPLIDQLRDIFKVMLQHKNVADDLFAYAMQYESHARSAAAPARGLPPLLARAPTAEQLESLEDRLAQYGGLFREQAKEFVTSLERSTDLDMRFLAVRLNFNYQFRPDPTSAKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB75</accession>
    <name>A0A2S5BB75_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY73981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB75"/>
    <dbReference type="STRING" id="741276.A0A2S5BB75"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1085"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1131"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1153"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1225" mass="133780" checksum="B4249AD9A107BC80" modified="2018-07-18" version="1">MASTLEVLSATTNEIIPVDLDEVFASDHDSATAAAPLGAESEQLADVVHLLRNEAAHVSLWAKLVEACTHRARWTVALQMCDEGLGAIGGGRGGGDPRDQAVLLCMKANIHLVLARKAPKTLPENPRAGPVAPPKDPHHPEFNSSNPVYTKAEYWMRAGKDLENALAQDPNSRVARDLQAALAMAQGQLDLAAKKWDAILADEPHHLVALMGKARINFSQRAFRPALKLYQQVLTLRPDFLPDPRIGIGLCFWMLGDREKARKAWERSMVVHPNNSSPAAPLLLGLLHVNASKDPLLPGGDAARAAAYERGLVLIQQAFKRDNTSSAAAAMGPLSAQYLSQAGPGASAAALKLAERMLAFSDARLLVAEAWLARARALDADPETASFNVHEILASYQHAVEANPDLTVAHLGIASCQIRLEQYPNAIFALETLIRKQPKCVEALAALAAIQANLAFTFHAVSDSNGARKSAKESYEAVLRIFKQGKEATGGDAANGGGGDRLIAKSERVRTLAEDRDLYLEIARLWGDEQNVERSLNAYVRAAEIEADKGASLDDDAAAEDETDDLYEPAKPARDHVDPRIRNNLGVLYFNRRPHNAHAATQSSSVQADLYRAQEEFERALQKLGAGLDGAERTSCGFDPLETDAAMTAISFNLAACYEALGDVDKAKTSYEVLLSQHKEFVDAKARLALLGIKSRRRDQWDESHDLIKQALTSQPQNAELRALYTYFLVETGQLKLAREFARSTLKELSRHDVYALCASGALNYVDARENKNPAKEAQKDRTAKFTRSAEFFDKALQISPQCAFAAQGLAIGLAEGTLGNGPLDAANSTAAAAGTNGAGAAAPLTEQQARLRNARDALSILTRVKESLNEASVYVNIAHCHFARDEYDRAIENYAMASKRYLHDKSSTVLWYLSRAYYHKAVREQSFADLRRAIDIGQTATDLNPKDLANVFNMAVLKQKGVEILYALAPEKRTSAELNVALEHLQASTTLFEQLANDPTKPTPYPAEVPRQRRSYGASLEKRFEATLATQTEYEQTEQGKVEQARRLREAEQKRRDELEAERLAQIQRQAEALAEQRRRMREEAEQWTAMSKAWADSDDEDGDGKKKRGGGGGGGGKKRKSTKMKGGEDDGGEETAESTDDDAAGGGERPAKKKRTKKEPRAKKPRKSKAAAAASDGADDARKMDLDDEDDEDGQPRLKVPKKRGKASGQVKSAEFIDSEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBN0</accession>
    <name>A0A2S5BBN0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBN0"/>
    <dbReference type="STRING" id="741276.A0A2S5BBN0"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="87"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="175" mass="19204" checksum="BFC7EF15C1AD6D75" modified="2018-07-18" version="1">MSTSTSTPQNPLKAIRRVVTTHDEQGQAKVWMDEEVDNKSPPGFSDGVSFGLAWVTDSSPADCQTTVDGKDLPIGELSSEKGSVVRYVDMPPKHVSPMHRTISLDYGFVIFGELELVLPDGSRTLCKQGDVVVQRGTDHQWVNASETEWARMVYVLLPAKPVVIDGKELPAKSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBX6</accession>
    <name>A0A2S5BBX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBX6"/>
    <dbReference type="STRING" id="741276.A0A2S5BBX6"/>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="273" mass="29407" checksum="DDFFFA1F9B801A6D" modified="2018-07-18" version="1">MLSLRTSSLAVSPFRSGPSFATPRRLLSASSSSLSSSTGGQPRSFPSKLHPGLYYHQNHPHLDPAHQGTTTLVSYLPTPPPSLKFSPTTIGTLRPLKNPSPGPSRVFSVELGRGGDVALTSESALDGPEADEGVPPISPRTLTENPDFLRLVHEVISMNLADDAWLQTQAKSVHADTHIHISDQRQPADANRIADPQDILGSVLVQNSHLVPDSYEPNHVAYRLVTEAGLMRLPGGLGERLREACERVWELEREAAAEEAAAEEAAAAEQSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC01</accession>
    <name>A0A2S5BC01_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_2500</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC01"/>
    <dbReference type="STRING" id="741276.A0A2S5BC01"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="459"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="711"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1029"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1047"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY74306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119470" checksum="1CF505DEDEA22CB3" modified="2018-07-18" version="1">MSAPSAPQISAEDIKLDHGKVPSSSDVKLDIATVLSGTADRASRIDAVKELVDDVKLNGPHAFVQHKIADAILKGLADKKNAGVREASCDLLRILVEQGVGNAVEPFFYEKVMKTIVAETFADKEKNVREAAVEAVRSVVQVSTSWAVPIFLPILLEQIKTAGKWQVKTGSLTIMDQLVISAPEQCARLMPDIIPVMVEAIWDTKSDVKKAARASLTSLCALVTNKDIEKFVPALINCLINPVEETTKTIQLLAATTFVQEVDSPTLALMAPLLSRGLNEKLTATVRKVAVIIDNMTKLVDNEHTIRPFVPKLLPGLLKVENTVGDPEARGVVVKAIKTLRDTANCQGDGSDLPPPKVVDAKHTAPIVVKGIKKVDAASKLDESSPLVDYIAQLVGNLCTARNWETTEWESSLVPYISLALPASIRANSAIEVARDLLQELAKEEGETVESFPDEEEGEDLCNCTFSLAYGAKILLNTATLRLKRGHRYGLCGRNGSGKSTLMRAIDNGQVEGFPSPDEVRTFYVEHDVDGDETENSIVSFVLKDKRILKSEEEIRNVLESVGFTRERQEAAIGSLSGGWKMKLALARAILFEADILLLDEPTNHLDVLNVAWLENYLCSLKTCTSIIVSHDSGFLNNVCTDILHLNKFKVKRYPGNLDAFVKFVPEAKAYYELNPLEERDLARTDGIDENFSSPQPPLLDGVKTKEKSLIKMRHVGFQYPTSPVQQLYDISLQVSLSSRVAVLGPNGSGKSTLVKLLVNETEPNKGGEVWKHPNLVIGYVAQHAFHHIDHHLDKTPLEYMLQRYQTGEDIEELSKANRKLTEEEEKKMKEGANVVVEGVKRVIEDITNRKKLKQSFEYECTFKGLSSSENIWLPRDELIRRGFEKKIIEVDSREAQKAGLLRPLVRKEVEKHFEDFGLEPEFTTHNTMRGLSGGQKVKVVLAAATWRRPHIVILDEPTNYLDRESLAALISALKDYEGGVLVITHNREFSESICTEVWAMKDGYLTASGHNWVEGQGSGPRIDQAKEGEEEDVFDAMGNKIDAPKKAKKVTSKDARKAKKERMARKKAGLPSDDEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC60</accession>
    <name>A0A2S5BC60_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein Crb2 Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BC60"/>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein Crb2 Tudor" evidence="5">
        <location>
            <begin position="1030"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="926"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1469" mass="155059" checksum="DD0941DAA96E4A0F" modified="2018-07-18" version="1">MAARELVPNTPTSTAQPTVASQQLESHSQSYLFGALDINPDSTIQSTDQHVREEDGSAVNEPVDGPAGGDEREDDRMSTVADSQLSPNKARPDAQEDDDQHEQGTGSHSQPVQGPDASRRADVTSLAAAESLDRTAHEADTFKRYPAHASTSVDRHETSASEHDDTASVSMDLTKAEGKVLHAQPEEEDQLLDVSQGDSTGRLDDDTQFPTQAVRDEVGQSESQKENASAGPVPPSAVRSPSRPTSTGISVALGPRNSRLNVGDEATGPSSSPTVERELLGHARAKRPLPFQTGPPAPASSADSDIPASALLGPTKLKDDAGPTQSSGIAVMPASTGESDFLATGLAGSNGPVNSTPAILNAAPPNPSLGPSRTAPDLAPPAGQSDAVKLSRNATEPADAVDVPAHALPFATSSAMKVAAPPKPKKKRGIFDDMSQSSGGSHAGQSQNGNGTPSNGQQSADEKPGASAEGPAATAEPHSPAADAASASASHGAEETVPPTQDEQAMEVDEPLPATMLHESEQDPPTCDDTSAAPLESTGAADLAATQDSSLDAVPNRLNGQTPLFALASPCSSPSRASQSQRDGLPPMSAPDSKARTRLSDISQLRSSSEAPPTQYEVQPTQKDYDIFRSSKSQERTIDNSERWHASFQVADSTEDQREKTPPVAPPAGRALKRKAPPPSPIRDGTAQIEEVTDTQRFGDADKSTSRQPLVNVDVSTVAQATQHAPTAPDSSPDVPLVKKMRRSASARPSSTLSAQIVPDSEGASPPVAGPSRLGVKAATDMADELEDDLSPLGSPRHVLATAKGKGKGKGKARSVAATESVDAVDFLAGPSAGTAAEPEETNYDVLPTAENGKTRRRRSASERRSPPPAPPVTKKSVSPDKGKRRAVDATSSDLEPEYALPAPKKKRKARSTTTFELDIPPPSPARSRGAASSPKKASPARRGSTRGSVPTKEIAAPAKKGKAKAEPKRRSTTGSAKARRPASPDAEEAPHAGSSRRRSVPARDESAGRDASVDVKPNIRRLPDTAPFKRVFGLWRDDQCFYSGTIHAASAGSFSVKFDDGNTGKLGAAELRYCQLAQGDRVRYYGKERDGLTDLDRNLIVVEVERTRGQTDDNEGQDRDGAEERPLEPADIITVEDHDGERHRLPLKSLFVAGYCGAQFDARRPTAAEFNAFDSSSAKRGESPKLCKAPQPVLARGLEIQDSSTLIFSRTAFIVTKAERLKEGQGQPKVEEYGATQIEWEGLFEVRAAKDANAPPVVRFATDAFADIDEIFLLSDRYCSTPKYLAALALGIPCLSTEFFFQSVKDKIRLPWQQFLLPAGHLRSLDAEAVGAMFRAATKQAFDLNSLEDSYRDGGVFGGCSFLVESESQRGYQVFSLLASSSAKLVHFTASAQDAKSASTYDHVLLLDESLGALPAPLRSHKGLVTVPWIKQCLVAGKLLPPARLTEKDAKCGPSATTVAGGAGGEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCC6</accession>
    <name>A0A2S5BCC6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCC6"/>
    <dbReference type="STRING" id="741276.A0A2S5BCC6"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="459" mass="50482" checksum="3AAD2E3BAE5FC9D3" modified="2018-07-18" version="1">MIPGLSGVHGRRRERPDSIPLRLHSDPPTMRDYRIACATYNGKLVSGQVQDVLSDSSEHLSAWLAPSLAHPAPPRTENDVRSNDPTEANEGAPDLVAVGFQEMIPLHLALAGLTRHALDVHDDKLRTAIESLYANSGDDGKVRYSLVGRRAIGGIALLVYARDDTVATRIKDVQVNTVGCGVFGLLGNKGAVAIRVTLEEDGADVKADSSWTFVTAHLAAHQGKNEARSSDWRNIVQRLVLDDRSREAQIYETGHLFVFGDLNYRISLDSPAKLDRESLMGELAELAVNSDEAQPPSKLLAQDQLRQEQQRGVTLHHLREGDIGFPPTYKYRPGSRDEFSPKRVPGWCDRVLYASAAEDDVKVLSYKSVMELTRSDHKPVAAQFLVPAAAVPGRLAASAPFAIDSSWRSKQLIGLILDRSIGAIWCLVMLAGFNRDLRLGIINISILVLTILYGRHRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCD2</accession>
    <name>A0A2S5BCD2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L22e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCD2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCD2"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14565" checksum="ADE2E80AE6490EBA" modified="2018-07-18" version="1">MAPSLVAAKKQKSATKAAPKKFYIDYSGPVNDKIFDAADFEKYMVEHYKVDGKRANLDGKVEFKREPTRLVVIAHDDNSKRSLKYYSKKYLKKNMMREWLRVVATSKDTYTFKFFNLSFEDGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCP1</accession>
    <name>A0A2S5BCP1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCP1"/>
    <dbReference type="STRING" id="741276.A0A2S5BCP1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="45042" checksum="5BD60302F0405813" modified="2018-07-18" version="1">MSSDLPTVAPGQTNVHIPHHHRGGTWLRRQVGVGAHKGDRHAARLLKSHAIAFVGEFVGTMLFTFFAFAGTTVASLPATSVTNSGATADAGAVQPSPNTSSLLYVALSFGFSLAVNAQIFAGVTGSVFNPAIALGLALIGAHTPIRALILTVAEMFGSIAGAAITSALLPGPLNVRTTLVAGTSISRGLFIEMFLTIILMLTVLVCTVEKSSIGAETGSISPISIGLALFLAELVGVFYTGGAVNPARAFGPDVVLGKFDGYHWIYWLGPALGATVAVVFWRAIQWIHFELGPRASGTPEASKMLLDGPNSDQIGDKSVLKDEEGKGNGHTNHPAQGDLSRVISGRSQADSVMSVVRAEPEPEADRIAMLEHSNQRIEAMLRALTTAREAPGSPSTTAAGSINRRKVSHEDNSLHATDQYYVPPMHSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCP9</accession>
    <name>A0A2S5BCP9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCP9"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="407" mass="43714" checksum="45A2026E8200908C" modified="2018-07-18" version="1">MMQGDMARAGHSYFGIVNNAQEAHAILEASKLGTAFAWPFSDPRHSSQLLPRVTRRLTDEELVLLFVWEEEEAGIRRWTDHIKWSPSRVSGAFLTYTEVPTGGDPSSRGDDTLIKQSFSATDANGSKMHLIAYTSKSAFTSGVLPLASRDPLVQHMLAQRTRTGHDPRDHPDPSFELFARSSEQRSQSSHSPTASSSAQLFTDSGRSHSNLSSSHSSSILSLATPSFARLISASSDSSMQEVLATAAPSAGLPPVDQDAYPAKRGKGPAPPAMQTSIAPIGGRSYRYDPVRDGPASAPPDVTEFPPSTPWHRSISSESSTHSAPTASPLSESPPSTRASPYDSHPRLLPPLEPPPTASGLVVPRSISPARSPEGSFASLVVENGSQHTMRGAEDRRQLRLLEGGFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCV5</accession>
    <name>A0A2S5BCV5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCV5"/>
    <dbReference type="STRING" id="741276.A0A2S5BCV5"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="786" mass="87128" checksum="6212EC451CCDBF18" modified="2018-07-18" version="1">MADAKLFQRNKLQEYVPPSSAVEVGVGLTRELRDELQADKKDKNFNRRKTVLKRVVASMTMGQDMSPLYPDVLACLSIEVIEIKKMVYLFLINYSRSKPEMVKHALPGLLSDASDHNALIRALALRTMSAIPVPEVIRHLVDPLRHALKDRDPYVRKTAAIAVAKVYMHDRRVVERADFITGLRDLLMDSNPTVIANAVAALTEISERSENIHLRFNSEVARRLVRAMSEASEWGQTYILESLIYYVPDEHEDAELMAEQISVRLQHSNSAVVLATVKAILYLMNYMSSERVVDDMCRRLSPPLVTLLSSGYEVQYIALRNIDLIIQRRPMVLKNEVKVFFCKYNDPIYVKLAKLEVIHRLASARNVEQVLAELQEYASEVDVDFVRKAVRTIGRLAIKVPSAADLCISVLLRLVKTKVSYVVQEAIVVIKDIFRRYPNQYEGIIGTLCENLDALDTPDAKAAMIWIVGQYADRIENSDELLEDFLETFLEEPVQVQLALLTATVKLFIKRPTAGQTLVPKVLKWATEEVDNPDLRDRGFIYWRMLSTDPAAATNIVLADKPAISTESELLDRGLLDRLLLHTGTLASIYQKEAHTFVRGARPKYLQDSPALSQEARDSYLEAMRLPILQPAKQTAPSNDEAPSLPARPAVSRQESSELMGASGGYRAAGAAATAGLLDDVDEGDDEEEGAALNPNADSRLVAGVQDDEDDDDDDDSDAGRRTPTGGQAAGGDGRDEPLDPYASLARMSMDDDWAGLGSRGTGSGGYGYSGPQPVNGGKGMDDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD38</accession>
    <name>A0A2S5BD38_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD38"/>
    <dbReference type="STRING" id="741276.A0A2S5BD38"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="313" mass="32982" checksum="E163F73530D67C0D" modified="2018-07-18" version="1">MNPSSRAPPHTQDTQDSSMLVHDVGSDTALPNGHLPERDSAPAARSSAASLFSLAGTTTIVTGGGRGIGQALAKGIAETGGSVACLDILAEPSNGEGEWDAIKKAAAKHGVTASYHVCDITNEERMLETFAEIERTSKGVVRGVVAGAGVQQMVPAIDYPMDGFRRIMEINVAGAFVTAKTSAKFWRDRGIKGSLVMIASMSGEIANRGLTCTAYNSSKAAVHQMCRSLAQEWGPDYGVRINTLSPGYIRTAMTDALLKEKPDLEETWMRGAMLQRLGAPEDLVGPTVFLLSDASAWMTGSDVRVDGGHTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD59</accession>
    <name>A0A2S5BD59_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1445 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD59"/>
    <dbReference type="STRING" id="741276.A0A2S5BD59"/>
    <dbReference type="OrthoDB" id="10262538at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047820">
        <property type="term" value="F:D-glutamate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2040.10:FF:000001">
        <property type="entry name" value="D-glutamate cyclase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1640.10">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2040.10">
        <property type="entry name" value="PSTPO5379-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016938">
        <property type="entry name" value="UPF0317"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022:SF10">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="D-Glu_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029755">
        <property type="entry name" value="UCP029755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29275" checksum="B212B7152A6F01F1" modified="2018-07-18" version="1">MTVTPASLTPHQVRQACREDSWTFPSTAGICDGYVQANLVILPSKYAQDFRNLCARNPVPCPLLGETKVGDPTIPARLARDCDIRTDAPLYRVYRGGKLVEEKKDIMSEWTDDSVGFLIGCSFSFEAALIGGGLVPRQIEIGRNVPMYATKVPLAPAGRFGGHMVVSMRPYPPDAIEQVRDLTRPFIATHGEPIAWGAEGAAALGINDPTGQNPDFGDPSEIREGEVPVYWGCGVTPQLSVMDSKLPEIICGHSPGHMLVLDIRDEDVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDE6</accession>
    <name>A0A2S5BDE6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDE6"/>
    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37306" checksum="8442E25A8C86880E" modified="2018-07-18" version="1">MDKIKQVFSHDSTKKEEHHHNAAAGTTTAPPTRSSAGDREQVVAPTESRAATAETTAPVSNTAPTSDTGLTGARRDETASGVSGLKTHEHEHGAHGAHLKEVAKPPAHQHQHPREDGILDVEQAKHAQHDHQHLAPVTHERHHVHEVEEVERQREVDRNIHHVQHHVQPVLDEQHGAETVQQKVVPQTEVRENHVATDEDKAQFASLATARDEFAEGPREKTIIDKGEKVVEHDHHHVHHVVQPVIERDVHEHNRIKTTIPVHQTIDDAPIVHQSVQHEPLKLDQFVAGGGDINSTLKHDGSLLERGQCERTVDGPAESMTEALGLSQSGTTGSTPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDT3</accession>
    <name>A0A2S5BDT3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDT3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34793" checksum="E84552FC78EF7DFE" modified="2018-07-18" version="1">MPPTGNSRRRSPRAASNPAGPPKLPDEVIQRIFEDVFEPRKSAAPAGPEYLPATEYLVLSKHYYRLLRPIRYRSMSTRSDPRRAATLLGRLAADSETRTWLKKLVLHVLPDFTAVHAFALSQFTNLTELKAHHGRASIWSSVPEDVSRSIWHDLWTTIARLPRLEHFICHAPTCRDPILHLPPSPSLKMITLAFNGVSPALSSLFNSSGVTDLCLFTGDAAAALREDRRFGKLPWQSLRRLKIYPGNITHSGDIDAVLIHMILEVINLRTPPPVFKELVFGVPSMPPGTWRKTFKLSLNLAARLSTEHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDX3</accession>
    <name>A0A2S5BDX3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_1950</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDX3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDX3"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY74974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="87" mass="9702" checksum="A739B23340223AC8" modified="2018-07-18" version="1">MAVHFQKCYAGADVPEQCALQKEDYLECLHHTKEVSRAMKVKHEYLTKTQHELGAKREQAETHAEGGILGLGLLKAVQDGQKEAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDX8</accession>
    <name>A0A2S5BDX8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Urease</fullName>
            <ecNumber evidence="2 6">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="8">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 6"/>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDX8"/>
    <dbReference type="STRING" id="741276.A0A2S5BDX8"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050069">
        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009682">
        <property type="entry name" value="PRK13203.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0533">Nickel</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="11">
        <location>
            <begin position="415"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="8">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="8">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="854" mass="91690" checksum="989DA0F2FC6535E4" modified="2018-07-18" version="1">MGFDLLPRELDKLQTIYLAGSLAQKRLARGLRLNTAEATSLIALVLHELIRDGNHSVAELMAIGKKILGRVHVQPAVPYLLHEIQVEGAFPDGVFLVTVHDPISSPSVNDDLSLALYSSFLPLPKEGVFPKGEEEPHGIADEEIPGAVVLAKGNIRINEGRERVRLKVTNTGDRPIQVGSHFHFSEANKFLSFDREKAFFKRLDIAAGTAVRFEPGDSKTVTLVQIGGNQVVTGGNALLNSSLAAPLADPSLTQTALSNLISLGYLHSSDPQAHATSDPTVIKPFELSRESYLSMYGPTKGDRIRLADTELWIEIEEDKTLYGDECKFGGGKVIREGMGQMTNMPDDETLDLIIMNAIIVDWSGIYKADIGIKNHKIVGIGKGGNPDVMDGIMPGMVVGVNTEVIAGEHHIVTAGAMDAHVHYICPQLCEEALASGITTLFGGGTGPTAGSSATTCTPSGHYIHMMMAATDGIPLNFGFTGKGCDSGPRGLEDQIRNGAIGLKVHEDWGATPAALDSALKIAAKYDVQVNVHTDSCNEAGYMQNTMEAIKGRTISFFHVEGAGGGHAPDQLVCLSEPNVLPSSTNPTRPYATNTLDEHLDMLMVCHHLSRNVPEDIAFAESRIRAETIAAEDILQDTGAISIISSDSQAMGRIGEVVSRTWRTASKMKEVRGKLPEDEGTGADNYRVKRYVAKYTINPAMLHGVSHVAGDVAVGKLADLILWSPENFGVRPAMVLKGGMIAWANVGDANASIPTVQPVIGRPMWASKPAAAALNSMLFVSQLSVDAGTIAKRNIKKNVVAVRGCNTLQKKDFKHNTAQPVISVDPETYEVRADGEHCTVPPATKLPLAQGYMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDZ4</accession>
    <name>A0A2S5BDZ4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDZ4"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="571"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="685"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="725"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="610"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1044"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1083" mass="115973" checksum="AAE7554F8F5E7A8A" modified="2018-07-18" version="1">MPDDRHQWAHAPPPDIYVSPASPRYTITPPTATPIRAPAERAPIAPSDEKKDHADAGSASLEPSREGRATAGKAPPTLQERTSYASTTSAAGSRTSDQSGGPRVSFLGSLAAALPSFSLSGFRLPGAPTFETIEHQDDDGVEDERNGRDYVARDEEEDEDETGSEVSSDERDEEDDGAEGGEFVLTRSDGPGPELPRGGDGANEQVDLQNTVDGPSLVSDTPASGTPVPTSTNASTSAKPGFPNLARTPSSAFVNASKEGNINPLTLHAIARRDSEQEAIRMVQARNETERRREDSAHSTVRGGGTGPAPHTPTQSRYRSSTIGFGNGDARSKSPAPISDDDRARLRKKRSTGLGRVQQDDTRSVRTASTGGFFPRTATMSSTASGVRSQPHASTSQAGIPDRHRAVSDAHSLAPSQTAEPKRKKGFFSRFGKKKKDRSEPESVPSVPRLPANLPRQDLETGSLLPSGSPVIEQTPPRPIALDAPLQAEKARTVKVKTKGKSHKDFGRLFLAQELVISPLAAPGHRPSVGSGQSGGDDDSVHSSFTGDNASIHSKTSRAKTDDGQPGSGSASKKRNAVWATKFSEDGRYFAVGGKDGVVRVWEVLSNPETRAATMSSSSTPPDSALPHDSPNFARSGFAPSTPSSAAPPLPQSATTGSGRKKGTPRSRGPACVLPVFASRPVREFVGHEADVLDLSWSKNNFLLSSSMDKTVRLWHVSRAECLCAFQHLDFVTSIAFHPKDDRFFLSGSLDCKLRLWNIPEKRVHIWTELPELITSVAFSRDGKFAIAGSFVGVCIFLEVETFRFHSMFSAKSTRGKNVKGKKVTSLCPFPLPSCTGDRLLVTTNDSRMRLYHVSDKIVEAKYAGHENTSSQIRASFSDDGRWIISGSEDRHVYIWDSGLGPTSGGGFHLKKKLKDGGGYETFAMPAHIVTSAVFAPTLVRMHLKHAEDPIFADGHTHLALLERTLSGNSLDLVGTHSRVSTANSAGPSTLDGFDRSDRNVLVPATTRDGNVIAGVESAEHAIIVVADDETGIISVFRNSPIPTDIPVDGKRSRHDRGASAGLGRERSKRWSRASAPHSDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE96</accession>
    <name>A0A2S5BE96_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_1702</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE96"/>
    <dbReference type="STRING" id="741276.A0A2S5BE96"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="14">
        <location>
            <begin position="24"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="13">
        <location>
            <begin position="671"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="819"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY75073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="984" mass="106098" checksum="22FB4F03D588E9E2" modified="2018-07-18" version="1">MHVIKPSWVAHPDETRATKPDLTIFSLDVHPDNSRLATGGLDSLVKVWSTVPILHEQAELDGDEKCPKLLSTLNAHTGVVMSVRWNHAGSYLASGSDDRVVVIWAHDGGRGGKVWGSETVNVENWKATRRLVGHQSDVAGVAWSPDDSYIASVGLDNVVLVWSGQSFELVRKLDAHVGFVKGVVFDPVGQYLATQADDNSLKIWRTDDWQLERNITEPFEDAPKATILRPAWSPDGAFVVTPNSMNGPVFCAAVISRADWSSPASLIGHSDMVQVAAYNPLIFVRDASQPPSMTNVCSLLAICSQGTVSLWFTDLSQPFAVLTDLFDRDVLDLSWSKDGKQLWASSSDGQIAVATFEYAEFAPVAPEGTRELLYRQYGYTPRNRPLLPRPVAAAVTTMTNGTSGGGGTVHQPNALVARKGPGAKRPRTIVPQSAPVVASAAFMNAPVAAGPAPSMNAYASTSAAAAAAPGYYDAPLNARKRRAPPPDEYPYYDDEPPLQEAGYGSAQRFSTASHRLQGHTLGRGDPAPDPLRELVPAYAKYNREVTFRVTNKGKEREGDRPRSLAVPAVMSVGKLGVEDSDAKDTLEWRNFADGPRASLFLRVASRVFTSQADLLDCWHAGKGEAEVTVVTTKKPLWTDYVPRYVVAAAGSPVFTAVSLEDGSLVVWSPTGRRLLPTLVLDAPCSFLTAEGPYLMAITALGTLTVWNLSPSIPKPRSIYPPLNISSLLASSSSQLHPEPVITTSALLPNGTPLLSLDSGATYSYDADLAAWTRVSETWWTKADTWEGRRGRNAAAVVAVAAGRGIVRTIEAAINEVAATNGDVEPTTEEATTTDATTPEGPPAEPTASDSTYRIAIALSHLESRLKAAEALDSPSEYRMFLLAYAKKLGEADLRSKAEELVKDLLGPVYYKPGRKEEDEWCPTVAGLQKRELLKTVLSELGTGFLHLERHSGGELTVFAPAAKHKITGSLAADYQEMVKKITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BED4</accession>
    <name>A0A2S5BED4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BMF94_1733</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BED4"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="36"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="199"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="471"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="698"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="890"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="POY75103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1369" mass="146955" checksum="F15E843EE8E22C8F" modified="2018-07-18" version="1">MLVLAGASVFHPPQRAALLARVHAAAPQVTSIDAVYVHYVEAVDAAAEKVLADPESKERKVLDALLKYGDDYALSETRPTVDVALEVGNAPGAIWVVPRAGTISPWSSKATDIARMCTLDKSVRRIERGLIFVVKAEDDKAQRVVDLVKAAPHMHDRMTQNLLDQKPAAKSLFERGSPAPLKTIDLKDKTVGAARETLVRANVELGLALAGEELDYLVDSFLASAATGRNPTDVELFMFAQVNSEHCRHKIFNAAWVVNGETKDNSLFGMIRNTHKLVPDHTISAYSDNAAVIDGSVVPRFAAGPSDASSAPVYQAKEEHMPILIKVETHNHPTAVSPFPGAATGSGGEIRDEGAVGRGSRPKAGLAGFTVSNLLIPEFEQPWETDFGRPAHIASALDIMIEGPLGSSAFNNEFGRPGLTGYFRTFAEEVPSLDQDGNRSTEIRGYHKPIMIAGGYGNVRPEFALKDKITPGARLIVLGGPGMLIGLGGGAASSMASGSSSADLDFASVQRENPEMQRRAQQVLDTCVSLGKENPIQSVHDVGAGGLSNALPELVHDADLGGVFEIRDVLVDDPGMSPMEIWCNESQERYVLAVGPEDLARFEAIAQRERCPYAVVGTATEEQKLVVTDRLLGQDAINLPMSVLFGKPPRMHRKADTIAAPRDTFDSSLKTYLPNAASQRDLIELAVERVLHLPTVGSKSFLITIGDRSITGLVMRDQMVGPWQVPVADVAVTKATYGFDVVAGEAMAMGERTPLALLSPAASARMAVAESLLNLAAADTPSLAHVKLSANWMCAANYPGEGAGLYEAVQAIGMDLCPALGVSIPVGKDSMSMSMGWNGESGERKTVTAPLSLVITAFSPVSDVHATWTPELQVLSEPTVLVFIDLANGKQRLGGSALAQVFQQLGSEAPDVEDPKVLKAFLEGCRKIRSEHPDVVLAYHDRSDGGIFTTVTEMCFAGRVGAEIMVDAFKKDDDAIAALFNEELGAVFQVRQADVAAFSQVFIRAGFPSTAIHPIGRVAATREDQAVSIASAGALLWSSTRAALQQQWAETSYRMQALRDSPAGAIQEFENIAREDNTGISYRLTFDPAQYVADPYLDKLTALNDRPKVAILREQGVNGHVEMAWSFAQAGFASVDVHMSDLISGKISLGDFKGVAACGGFSYGDVLGAGNGWAKSILLHERARQEFTAFFNERTDTFALAVCNGCQLFSQLRDVIPGAENWPFFKQNLSGRFEGRVCVVEVVDSPAATESVFLRGMVGSSLPIAIAHGEGRATWIAPASAEQGKHAVAVRYVDPSGQPTERYPYNPNGSPDGVTGVSALNGRVLALMPHPERVTMLGANSWYPRADSKSWKGRGPWARMFEEARRWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF03</accession>
    <name>A0A2S5BF03_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF03"/>
    <dbReference type="STRING" id="741276.A0A2S5BF03"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="338" mass="37459" checksum="BB309BED140653BD" modified="2018-07-18" version="1">MQRAVRSLLLAIPNACRTGATRSAAPRVTAAVASSSRSLATQVVDTPFDPPTTVTGAQGGRTAVDLAFPLADSKTVHLPRSTPSAPSSSGTGAKAPRYSRHSSRVKGRTPAKPPKAVAPGIEGATHGDVKVYLPSVFMRLVRNTAEYKDDPYTATFRTALQLTKPDIANYLKNVYGLEITSIRTMNYLSALKRNPIGGGKSRSGGTKNYKKVLVTMKEPFWFPEEKSRAWLNEHFERDRTEEMRDRKMLKIGDGNKYKVGSFRYRGARFASRRAELKLAATSSEKVDFDARAPGDEAAQKRATGLKRKRNVMRSREEQVVEQRSLLQREMDRLREAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF27</accession>
    <name>A0A2S5BF27_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF27"/>
    <dbReference type="STRING" id="741276.A0A2S5BF27"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="341" mass="35742" checksum="E5ADB630111CC99C" modified="2018-07-18" version="1">MHSQEFLDIGRHCKEPSCNQLDFLPFKCPSCRLDFCSDHWRPPAGHKCSEYDETKADNRVPTCPLCSQPVSFPLTSDPNIAMDRHLSTACPVLLPELASSLSSISSSGRGPAPKRSPNECSARGCKTKMIVPIECDSCHRKFCPSHRWKTDHACESTGSGSSNGATGGSGGSGKKAFGGLFARSNGPAKQPGLAGLAALRRAQHERSGPKKSGTSAAAAKSTSNPLVANGRTAPGLVPTTANDGDSDIEIVSYKPAPGAKAGGTDQPGKSAQAGKKALASVGVASKTDKRARAEQESKRKALEVRAKKGLLTETEKVQYATLQALAQREGKNGEGDSCVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF59</accession>
    <name>A0A2S5BF59_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_1486</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF59"/>
    <dbReference type="STRING" id="741276.A0A2S5BF59"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="105"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="265"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY75416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="751" mass="82605" checksum="BD8162DB813D0337" modified="2018-07-18" version="1">MASTAGSTPAPLQRPGLSGSAQSRVGSSSSTSTPTTAPTATTTTRNPLQAKVTRLLSANLEDGATRAALDTLGQVELAASRNSTTGSTTTTTNGALSQQQTHGGMNTTTLRKGGLRKEVDTQMAESSRHFLRAFSDVNDKLSILQSHLDAMNVCCDEVQTELEHANSGTRYLLEHAQGLREQRTTAAIQQSLVHVFLARFTLTDAELRALSSRDVPVGPELFAAMDKTERIRADCRALLSGEAGEGTKAGCVRAVCREQASLGRLDIMEYTAQHLEAGYSKIHKWLAFEARGFAKDVLEVSHTVREAITRLKNRPELLNEVLTVLGTTRSTSILNLFLDALTRGGPNGLPRPIELHAHDPIRYAGDMLAWLHQAMAGEREFLESLFGTRGEDERDLRRVGQVHALSRHKRMKSTVDGGTAMQRTDKDWVKKLLDRDFEGCGRPLKIRVQQTIKSQESPIMAYRIATLIHFYKVTMERTVGEDTLMSGVLSEIKDHAYEAFFETLRAQGRSLLRFIQPPAAALSAPAQLRDVLSTLREILTVYATSLLEQEGLPQAPRTLDGEFREILDAALDPALEMCERMAEMRPAEWDRAVFRINCDEAVLAALEGFDFVHDRRDAVQGEEEKHVETVTAAHYEYLLRESGLEPAVKALQSRADDAPLSSLENASAAALQAAQTRFSAFLSAVDPVSSPRLSLLPPQVAGHAHSDALRRISDTYSTVYEAVSNPKNGYERPESVLRRSKEEVRTLLVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF98</accession>
    <name>A0A2S5BF98_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF98"/>
    <dbReference type="OrthoDB" id="2526979at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="839"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="984" mass="104762" checksum="19FEAE53A1652834" modified="2018-07-18" version="1">MSRGPRNSGSSYLTHDAPQFPDLCTYSSLHQCHKSMRAAPGRAAPATNRSPNLIAGAVPSDLKRSSSSIDSQLSTPSTEQSSWLTGDTDGGLQASTNSLGVHTLLYEAQLDLIAHKTQDAIVRLERAVALGSSAACATVANLLARGWRADFIVPATSPPAEALPRASRSGKSGANGRSRPNPPARLPSNTTGQSESPSRHPDALRAVAFFVKGLELELGKPSHAALKPSGVVCLCEENGLDDEESDDEEVEGRAFDLGRTFDLLTGVRSLPPAPASLSALRSVRTELFAVPQVTDAHRYNVLHAPELTDATAPSTSKSESFNDSLWYRSSTLCTQILCHPDVSSAVFPSDEASDLVGTWLRDPTKSPPSPDPQRLAEAVCGLSRQRAAVAISSLYVLALQAWSAPGTACSSTSPPWSPPWSPPSETALAAQRYWSAIESIAAHFARDGGLGIKPADELVERARHRLQSLNHRDLGADEPWRQAKKRRSKACALSDKTESPTGSPPGLMLSDQGLALPPAAWSASTASKTSSRDEKRSAAFNCHGADDSTRSSDRRHAAATPAAASTSQTASQAAAVYSSPPQSPVERSKDGGLHASQSELATSPRALQPPSPSACTRPPDAADAGLGSLPRATSMRSIRSTFSTASALSAFRHNPLKRYASGHLRRVSSSVSVCTAPPDFSDPAARYVRGKGKGRLVEPGEALDRAATSTSLPAETRRLNEPAPKSWLSRFWSSSNTAAHERTASERLRKALRRHEEAYATAIDYWGETEFLEEEEEGGEADDPSAAPVPPSEPPAQTTQADNLRASLAASGISNGTPHRAARHRNRSGHRSFALTDPTAFTSTASSSRGSSLQREARLSDSDGANRSSDFSKPSQPDSPRKAARPPRSPRKKSDRLMPHAVPMDPLLLELEQRSRVGVKTVCAACGKKGLNFPACRTCQQTYCSRLCRTNPRHASADAVVRSRQAKLAKEAGEEPREGVVSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFL0</accession>
    <name>A0A2S5BFL0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_1461</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFL0"/>
    <dbReference type="STRING" id="741276.A0A2S5BFL0"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="354"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="119"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="578"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="686"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY75558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="772" mass="82650" checksum="25B1012A69DBC809" modified="2018-07-18" version="1">MDDAAMEAAPANASLNAAAPAVAASTSVALPHLNGSEPAVVLGKKRAREVDSLASPAPPLPSDPLASTNHSTSTASAAAAVAAATPNADALAHIDLVVYAGYEIRAEYPSPYPLDELPGIAPSSSSSAQVAHSGNTTNCSSGTTTARRASNAARAGGRKSAEPSPAPLPTSLQNGLPPSATSDRSTRPQEPATFPSIFADSRPISPELGAVMPEQEAAASGRPELPEPSEGGEQNALTGDDSLSARETIDDGGSNLSQPVVSEVNLTAEGDGAEPSAVAEPVQPVASTSTLPLEPISSVSQPSPAPASPSNIPTSRGNRGRFLPKPAGETVKAKRAAERAARLAAEAAGGPAVPHMTQRQQRELARKAREERDRENKGKQAPQSEVRLLVCDRCFKYMALPAAYLAHQKECQVTKPPGRRVYQRGATSIWEIDGSHAKLYCQNLCLFAKLFIEHKYMFFDVDSFTFYLLTEAMGKQEWVLGYFSKEKISYDDYNLACIVVFPPFRQRGWATLLIEFSYELSRRFSATPGTPERPLSELGQRGYLAFWISVLVRYFRAVFALRDRPPLIDTVISDQSRMSLSPSKNSQADDEDMERERKKRLRRSKGWEGELPSGAKSLALSPAKAFTLRPLPPVSADTPSSLVKIGGVDGDEVFSYATSLDELAQAVNMRPDDVAYALVESGLARWRQGDEEDQQQSPEGDVKMEDVDDATELAGPRAPQAAGEAEESSKTASMPVAQELELLITPELVEEVARAKTVKPMPMLDVAYVCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFW6</accession>
    <name>A0A2S5BFW6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFW6"/>
    <dbReference type="OrthoDB" id="2786563at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55188" checksum="ACF03A9D9D5B4FCD" modified="2018-07-18" version="1">MTDRDRPLSLLSLPDELIENIVDKAIGCHPTPINTLLICRRILPLAHRILYHTVVLRSSFQQRALRATLERNPRLRPWIKILVLHGITPATPEVCERQRALLSMATSVEHLYLSEYSNVLLTALAHDATWSKGWTKLRTFRLRGLEPLYHTSPDEAGDPVKAVEDLWRLLGRFPTLQQVAIRSAADGTSFFPTIASTAASFPSIHSFHASGPLTMMPNLKVLSLSPAPRRRRLPIPPASVLTKASATLSHLTIGHQHIGANLQRFPALTFLRLEPDSFDPDTVLPCLLSSATLEEIVFGYGAPVSAALLRGLVIHCATLRRLTLDYDRSPARGKALQDLFVRLSVNNVDRFIDGLAELRQRSRPRRTVGSEADLRDILSLAADRKIDVTGSALTCLDWEAYFDDKAAAYLVNLARSTRDADRIDAVGATLVRNALVNDQLGPIQQYLGREGALQAFQRHRPSLSAFFESSFGPETATGGLVDLSGPSERSVPSVPLEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGG8</accession>
    <name>A0A2S5BGG8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enzyme activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGG8"/>
    <dbReference type="STRING" id="741276.A0A2S5BGG8"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1023" mass="106330" checksum="53C938EAF0A9FE4E" modified="2018-07-18" version="1">MAFHLDLSGTGGASSTATRGASGSSRSLTPVPLLDSPASDPTLAPYSYSQSSAHSHPIKYHRTSAGEAVSAVGPYDLAPTRGLPPPPAPPVRHQTANPYDFASPAASAADSGPTRSASGRAKGPPMRSTTMDDAYYVGPGEPSAVTRGKAPVNAGIYGAIGTAPPRAPGLYGQGNHSSPSLVESGSPELLPTHLVPGLDSAQSPPQPSGSSFTPFDIPELPYMSSSNAVDDLHVGIENMRFEQQQQQQPAMMQQQQRPPSRSTAPSGRTSIDLIQQQQRDGRRYSPSSIGSLGQVGPDGAMEIRGYGGGDGTASVYSIESNQAMAYPGGAGGSGSTWGGSAAHGRHDSSSSSRLTAAFDAGAQHDYRHDPYGASASTVDGYSEVDPVAARRQSEGSYLGYEDGYAQGMAAAAATAQARLSQPRMPSSMQQPQPGYSGSPALAGTDYFSNAGPSSSVLAAYYPPGGEQAFYGSHSAPPHERYAHAAGQPPGSVTFPQNGTFASPAGGQWGYDHPAAAAAQNPYYAAATGQLGLDLGGGAGAGPSAAGPYGGMQRGVSSVSSLAPPSTPGSSLSRSVSSLNMPGGGTMRRKATAASSATAASSSASSGPTITKASIDEYRQRVKADPDPEAQFNFAKYLIEAAKRLNSGTNSDDRVAKKYRDALLAESLKLIKRLATQGSGLGKAAYADAQFFLANCLGTGSLGLQIDHEKAYNLYVQASKQNHSAATYRTAVCNELGAGTRKDYARAVLFYRKASALGDTAGMYKLGMILLHGHLGQQRNPKEGLAWLRRAASQADDENPHALHELGLLYEKPPLLNPAGGAGSLGAKVAAQQAAQAGQPPPSSAAAAGGASATLVPFDPAQAREFFTQAAQLGYPPSQYKLGLCYEFGALTCPVDPRRSIAWYTRAAERNEPNAELALSGWYLTGSDGVLKQSDSEAYLWARRAANKGLPKAEYAVGYYAEVGIGVKADLEEAKRWYMRAAAQGNKRAMQRLTELKKLGADKRGAGGKKRPTRKDAETECTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGQ9</accession>
    <name>A0A2S5BGQ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGQ9"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="151" mass="16515" checksum="F39067B8D83BCAD9" modified="2018-07-18" version="1">MATLLQKIKSAVNPPSSLNPEYADQPRSQSRGRDTGVTPTGRGGRGNMSRSRVRDGSELAESPEDIAAARSRSRSRARKLHHGVDLPVAHGRGGAGNVASEQRDAASRERERRIEEEDAQAEVRFAEQHRTDEHLVGRGGLGNKDKEHLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGS1</accession>
    <name>A0A2S5BGS1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGS1"/>
    <dbReference type="STRING" id="741276.A0A2S5BGS1"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="396" mass="44146" checksum="6FC857CA1CDC7961" modified="2018-07-18" version="1">MTASTSRPTLNGSHDHRPGHPAPNQPPRSNRFIAAVTSRPVIAVVSVLLTLLFVSVRSPDSPARPRQSSAAVRRGHTSGGGAVARDLTPIQATAAGAAAGEKLLILTPLKDASPWLDEYFENLARLTYPPNLISLAFLVSDTTDDTIAKLQRRANRLQKLPRAQRYDSITILQKDFHFNLGSEVRHGFEGQPVRRSFIAKARNWLLTAALRWDHAWVLWLDVDVVRYDPNILSDLMSIDKDVVVPNTLWHLEQSWDFWGFDRNNFAETEESLALLKRLGPDVMLVEGKSPLPGIVFFLSDLTHREIVRSSGYRELMTSRLHLVDMPTHLGLAYVPLDGIGCTFALVKAHVHREGVTFPTWVFDNEVETEGFAKMAKRAGREVVGVPGILVFHAQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH25</accession>
    <name>A0A2S5BH25_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BH25"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1143"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1254"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1263"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1371" mass="147657" checksum="155E141A3FB10B69" modified="2018-07-18" version="1">MSTQEPLLGSAWLLSQSPGAPNAGPSEAAAAGPSSATHTRITPTVCDNYSHFKRLLDQSRRQSDDAISTRLNRAAALAGTVVSGRGTAREMGQQECDNVWRDITARWTERGDALRYCDRALGHTARTGEIASTDSTRVASSSLSSSSTRGTGRDRTRDEEIAPVRGLSADWKEQGRGVATEAELKSLPTVTARMGFSPPLGTTTFLTASDATRPAATRLYFTYIASKSDKDSPGDRVPEIWTNLSTDRAETTSDVEPEWHAVPLSPSPEQDELYVTSLPVPSIASERAYEFTYRFRNAKTDETEWVGSSDANGKFRIVDGSRLDTRWEGPDLASVKSDDWQRFEGDAGQGDAAVGRFKLDWNEDGTTRTRDVDLGSLIPEEWRAAGAIEGLVWERSSLYWLAPRHLRGGHPLESLSPVHPGQLLVLRAKPTPKHLAHRYLVLFPFSTSNVCSYLLGPSTEGGAVNSTSLRLHCEREFFGTSTPGRQSVKAVETTGHLAVAWGAEGHLRDLVQLAISSARAAQTGEPIKDLLKAARAAAFELEDPKPLGVCTWNALSGAEWNSKDYTASAVLDWLDRLLGTETDTDEGERRSLAAGAIKSVLLDDGWQDATTYIDYDEPDGDSHATRKALKSFACRREWYDLDEEDDDDDDEQGDQEVAAARAAAQKNKKHSLDSGYDGSPVAAQLRQLDDEAREGTCVELRDVVSRIKEKGIEQVGVWMTLAGYWDGLHPEGALADTYSLRRVTLRSPVDGSDQGHMYLPVLADLRAYYTDYFTSLHAAGVDFVKVDDQSKIDWFFEQEVAEEDEEDAAPEDVGELRHAMLHEMRAAAARIFGTAAGTVIHCMAGSPRVFGGDLAVLGGPAGAGRAVIRNSDDYWPDRDDSHRWHVAINSVMTILSSALQFEPDLDMAQADHPYAGAHLPLRTFSSAKIYATDTDSVEGWSSLVATTRNGPRALQARAAAASGAVLEGRLWDDVLSEQATRGGTPALIAGLPVPNARGAHLGIWNCSKNGSATAVLDSKDVGEALQSLRKSDAATEEPSQLVLTDTDGSFATIVESADVAGPVTGLRNFAKPIHAIHVSQTQAHMLVLAPLMPLGRISSSAGDQAMIGCLGLLGKTAGLAAIRSIRVGKQGIAASGSALDEFTRKVDSGPSQRPEGLVRSVRSDATPTARAFPSPQGRLPFLLAYVAGFFRHSSTTEPGASSNTSGRRSPRAELSAMTREFLRSPFRTFFGELRALVTFSYAAIVWAASGSSRSGERVQGRVGSPAGSAASPLPATSAQTSGASTATIEIELDYVSDRLGFYLSTGLTKDSLHFTLDGHDIDSSSVRTNKHTHEIVEVDVEKAWRASTSADTGLEGTAISKPWVVGVSLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH29</accession>
    <name>A0A2S5BH29_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH29"/>
    <dbReference type="STRING" id="741276.A0A2S5BH29"/>
    <dbReference type="OrthoDB" id="336321at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="3">
        <location>
            <begin position="86"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="371" mass="39662" checksum="4E27B57BE5489359" modified="2018-07-18" version="1">MTSLATLLPRLAPHRELEWQVQLDTLAQAGITTDVDLVFSTHVAPRPGLSYEQLREITDLITGNLAAVSSTGVELALQSRDRKGKQPARFSTSLEPLDDWLDGGLEQGEIVELTGPKHAGRTALALYTLLLHLLLHPDARGAWFDSMGTFDPHRCLAILRDVLVPRLLSLGGTFADEGEAEPSPEQLAIAVLDRLAVSRVQKASEVLDVLAGEVSSGSTGPQLKMVVIDSLDNLLGGEALAAGKAQAHATLIAFMRRLTSMARSPEAALAILVVTTVPPSDASTRQDKNAGRRGVSIPSTLPYQPPLRYALDHTLAHLVDLSLLVTPAASLFGPEDGRNRGLVEVLKNSRGQEGGLVPFELLHGHDLSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH51</accession>
    <name>A0A2S5BH51_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH51"/>
    <dbReference type="STRING" id="741276.A0A2S5BH51"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="338" mass="37027" checksum="AEC44F5F55F31A5E" modified="2018-07-18" version="1">MSDLISHLVARAEQRHEPSSPDALYGYVPSISLAAVFITIFGLTTLIHLAQLVIARRYWWMTCMVIAGLLEILGWAARLWAHYASRNFDAYVMQICCLIIAPTFISAALYWCAGLMMAHIAPQKSFLSATLFKVVFIVADVVSLVVQAVGGGMAGSAVGTIHHQQVVDGSHIMLAGIVIQLAVMVFYVIYVAVWVLRAKDEVRRAGRKIHLMLVAMLLSSIGVIVRGCYRTPELNEGFSGWIATQQIWQLFDAIPIAFASFVLNVIHPHWFLRYPAEVDVQLPYSEKPGYSAEPAGVAPGRPASESTVADHEAHGAGSPYGNKEGNRDHSEIPVSTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BID5</accession>
    <name>A0A2S5BID5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BID5"/>
    <dbReference type="STRING" id="741276.A0A2S5BID5"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="190"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34821" checksum="E61C14836E2584C4" modified="2018-07-18" version="1">MSVAQVSRSVVKAILAIETPEGAGAMVRRSIGTSQLRNFTPFLMLDNFLVKEGAGFPDHPHRGMTTLTYMLEGEFEHEDVKGHKGRIGPGDLQFMIAGKGIMHSEMPVHGPGKKDPFGLQLWIDLPKEHKLVEASYQERRAAEVASAHPTENVEIKVVCGEAQGSEKEGLVKGNVRPLGGCWFMDFIMSAKGERVFQPIPKGWNAFLYTLEGETVVGDASSASGTGAPARPIKQYHTAVLSNADSETGVWLESASDKARFVLVAGEPLEQEIYQHGPFVMTSRNEIQQAFMDYQFERNGFEGAHGWRSEIGKKMTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIH2</accession>
    <name>A0A2S5BIH2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0345</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000003">
        <property type="protein sequence ID" value="POY76560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIH2"/>
    <dbReference type="STRING" id="741276.A0A2S5BIH2"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000024">
        <property type="entry name" value="Probable threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="88"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="315"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY76560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="638" mass="70547" checksum="ED9E1D73B13A6B93" modified="2018-07-18" version="1">MPLKYFSTRGGDERLSFEEAVMRGLAPNGGLYIPVHLPHLPENWQHDWAKLSFTELALELYSLFIPDREIPRSDLQDIIDRSFATFRHENVTPLHRTGEKEFILELFHGPTFAFKDVALQFVGNIFEYFLQRRNAGKPDDQRERLTVVGATSGDTGSAAIYGLRSKQDVSVFILHPKGRTSPIQEAQMTTVVDDNVFNLAVEGTFDDCQDIVKSLFNDMEFNSRYHLGAVNSINWARILAQTVYYFAAYFAVQSQIPYDVLEPEIQFAVPTGNFGDVLAGWYAKHLGLPMAKLVVATNANDILARFWKTGRYEKADSGEPEHYAEDDDESAIQDGESGAAGGEQKPPSTPRGLLQRYPSLSEDEAFRHQQQAAVAESVAQNGASDGQQATPRANGSSSRFGMTRANTNGSLASKKEAAAASAGTVAETLSPAMDILVSSNFERLLFYLALEGTTAGAVAADGEVDGGQAARVRVAAEHVRVWMDRLKKEHRVKVPRMCVEAARRDMIADRVSDEETAEVIRKYYSKKDEFGSYVVDPHTAVGLAVANKVAKTNPPNIIQIVLSTAAPAKFSDAVSEALKDHPDFDFERDALPEEFKGLLDLPRRVIDVKNDREQVKAVIRENVDKLFSHHAATSTVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIH4</accession>
    <name>A0A2S5BIH4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIH4"/>
    <dbReference type="STRING" id="741276.A0A2S5BIH4"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015403762" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1086" mass="113987" checksum="A4A012BAF4AB4700" modified="2018-07-18" version="1">MNFLSSLSSAVLSASSAALSSASGGVPGVQGYQLGDRVTTYDGKSIWTLYTGTKRDDGTPVSVFSYDLSSPAANAHMRPADRKALVPLARNAFRKLRALRHPNILKFLDGSESDSAIWIVTEPVQSLATVLESAGTAVGLAEESKVYGLLHVASALAFLNREGQSVHGGLRTTSVWVTPGGEWKLGGMEVCSRLDEPDAAMWQYGGLLPDSKVHASPEVRRGGWTALKEYDPSTLDSYLMHLFLYTVFNGPLPNSYLSPSASETPSLPQQRGSVPPALFQPWRRLGNPNPAARLKTTAFLDLGQHPGEGWWPSNRLVKLSAALEGFALATEDERTSLIRTLRAIAAGAASSKTAALPNGFLKYKVLPSLVHTFEFSSGSGGAPLLPVILDLASESSASANKATGDEQNEKEFQRDVIQPIVRMYATPDRAMRMALLENLERYADRLTNKDVNEKVWPHLQTGFGDVVPVIREATVKAIPLIAPKLNDRILNNDLLRVLGKTQTDVEPGIRTNTCILLSRLSRHLQTSTQRKVLIPAFARAIRDPFVHARIAGLMALMATCEVFEKEDLAGKVIPAMSICLVDREKTVRDQAYRAIDMFVKKCEALTASMPETTTTDTPTGQSPALQAAAQNQPGLATNAAGAAGALAGWAFASVSKKVASGAIFSKWKKDLSTAELAAPIERREATPPVSSPVTPNLNGGPRPPRISVDSTGSNGFLTAGGLSKPAEDWGGDLMDVNDDDGDWNEFESGQQSSTAQSRVDPLAARLSATGRPKAARGRLAGGAGSGSSLRLGAASKNSSLRLPMDMDATDSWDIDADEAASASSPKKKPIPRAVTGSATSRPIGGANPVRKPLLSKSNDAALLALAAGPSSGAKAHTMGAACVVAPGVPAAADRSPAPASATPDPSSTPAEDVSNLDPAPSPAPPNPWSDHDDPEPQSSAHARTDSSYLPPPPIEASPFGETDFSAPIRGTYVPAAETLFSPDVSEPVFASPGQTEAPAALPPPIVVPTVSPPPAASALVSPTFDPGTIAAAATTPRSASPATSIASASTTATGGAPLTKEEKAARLAQAREERKARMAAAKAQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BII0</accession>
    <name>A0A2S5BII0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BII0"/>
    <dbReference type="STRING" id="741276.A0A2S5BII0"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="182" mass="20102" checksum="F1BC5275C64F6F8D" modified="2018-07-18" version="1">MSGMDMGSSNSTSSAASGMDMGGSCKISMLWNWYTTDTCFLTPGWKIRNIGDYVGTLIGIFFMVVALEAIRRLSREYDRRIRKAYIHRETLALQVFAQNMNKGQPSEPAPFRPSNKEHTVRTVLYGMSFGLAYILMLLAMYFNGGIILAIMAGGAAGYGIFGRDTGAMEGRPEEHFKGECCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZE2</accession>
    <name>A0A2S5AZE2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_7102</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000170">
        <property type="protein sequence ID" value="POY69904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZE2"/>
    <dbReference type="STRING" id="741276.A0A2S5AZE2"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="13">
        <location>
            <begin position="9"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY69904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="462" mass="48600" checksum="8749C2D7C0E505A5" modified="2018-07-18" version="1">MASSDPSTALAQAARDAFTASQLLDASERHLALIAVKDALTAAKQEILEANRKDIEAARDQVAAGSMSSSLLKRLDLESSADKYDSMLQGILDVDSLPDPTGQVTYARTLDDGLELHRVTCPIGVLLIIFEARPEVIANITALAIKSGNAAILKGGKESIHTQNVMSRVIQSALATTKLPSAYIQTVSTRSEIASLLSQDRYIDLVIPRGSNSLVKSIQNGTRIPVMGHADGLCAVFVDESAVPEKAINVVVDSKTTYTAACNSAETLLIHEALLSTLWPKLAAALLSAKVALRCDESTLAALTSSSSEAASHPAFSTLVSASTPEDYDTEFLDLILAVKAVPSAAAAIQHINSHSSHHTDAIVTESDENARAFSRGIDSAGVYVNASTRFADGFRYGFGTEVGVSTGKTHARGPVGLEGLVIYKYQVRSTAAAGHGTSAFGSGPGQKPFLHTELPLGQSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZQ3</accession>
    <name>A0A2S5AZQ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6994</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000155">
        <property type="protein sequence ID" value="POY70004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZQ3"/>
    <dbReference type="STRING" id="741276.A0A2S5AZQ3"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="533"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="687"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="768" mass="83269" checksum="BEB2DB2807E0F5E4" modified="2018-07-18" version="1">MSLSTRQKFLRWIGHDPVITEAASTTDFVKSHSSDLPGQAKDYVKALLPIHRWILNYNLVWLAGDLIAGFTVGLVVVPQSMSYAKIATLPVEFGLYSSFVGVLVYCFFATAKDVTIGPVAVMSLSISHSIAKVQARAGGDQYPGHVIATALALLAGSIVLGMGLLRLGFLVEFVSAPAIAGFMTGSAISIAAGQVPSMMGYSKLFDTRASTYKVIINSFKHLPDTKIDAAFGLSGLAFLYIARYVLNRIERNARNPVVRRTAFFANTFRTAFLVIVSTAASYGYLRYKNPKKLPISVIGKVPSGFQDMGVPIINSDLISLIAPEIPITTILVFLEHIAISKSFGRVNNYKINPNQELVAIGFNNIISTFFGAYPSTGSFSRTAIKSRAGVRTPLAGVLTAVVVLVALYGLTSAFFWIPNATLAAVIIEAVGGLIASPRQSYSYWLASPLEFLIFIVAVFVTIFSSIENGIYFSIAASAALLLFRVAKPRGKFLGRVRVRQEEKDGSSQARDVYVPLNPDGIRNADIRVEAPPPGVIVFRMEEAFLYINSARYTDQIVDHAKEYTKNGVDYSLIKQGDRPWNDPGPNRFQQKGKWADREHDRSLQNAAKPTLKAVVFDFSGVSNVDTTSIQALADTQSVLSRYAGHPVAFHFATILSPWIKRALLAGGFGRDRDDARPVELGDVVPQRDNADELSRIPSLPAFAPSQKPESGKEHDIEEAASLPYTSTRSDSLDKVPYAASAADSIVDSSLAYFHLDLPTAVSAAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZT3</accession>
    <name>A0A2S5AZT3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000153">
        <property type="protein sequence ID" value="POY70036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZT3"/>
    <dbReference type="OrthoDB" id="2538248at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="449" mass="47000" checksum="939D497BFF36995A" modified="2018-07-18" version="1">MSATGAPEVPGNALKRVYKRAEAAGTVDDFTLKHVRRALDGDEGWTCSDAEWKQVRTQVKAEWAELLGADESASPSPQKKKQRNGQRSGKGSTSDKYGRAAEKNLKVFMGALGGVLGGLTAGADGSDAEGEEDGRADDAPSPSGSASSSSRAPAAKKAPKKRKTVVTIASSDQEDDAPAPPQPQPPQKRSRKQANPQRRVASDRIADEVLVGPASAAQTGAPPIASTSKAGVDVPINMNDSDLSELEDNGPLPGARSRKGKGKAVESKSKKEKSAATSKSKKSDKKAKERKAPALKPGDAPRGTDAEEDRITKLKALLSAAASPRPFTATTGAERTLAVSRRKEILEGLLKDLGLPVKGDKLLTLARAKDIGEKRLLAKEMAELGGTAHHTGLRTGKELHHDSSLDDDDESSGTASGPGISASAKKKQVLAERKKFGAFLGDQSSDDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZZ5</accession>
    <name>A0A2S5AZZ5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COQ9 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZZ5"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="1">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="293" mass="31435" checksum="4550B3125524454A" modified="2018-07-18" version="1">MSSLPRQLARAALPHVAQHGFTTEAFLAAAASTSASTAPLPPTLPKPLSPRTLHALYPSPPAREPFSFSLKGLALGNGGKRSLSKRELIQLARGQGTALARGERTGPARALVNEWLIQGRERMVDEVRASGLRGVEAYKRGIEARLRYNQDMLDRLPSALALLSAPTSTYLSDLSAALPVPHITPHLAHVAEIAHDLAKAGGSQHQGTEWYSLRLRLGTIYALSELSLVAPPSSPTVAATPALPAADRIQQAIAYSHRLFDQTGRVGQELDNVGMFAEWVRKSWMGIGRSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B068</accession>
    <name>A0A2S5B068_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B068"/>
    <dbReference type="STRING" id="741276.A0A2S5B068"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF263">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="129"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="270" mass="30022" checksum="7B2E6E89FE824622" modified="2018-07-18" version="1">MSDAYELVYHAGIPGRGEASTEAVFIRLFFEATGTPYVDTALTGGQSAVKPYLDGSFQGADENPLPFAPPVLKHGNVVISQTPNILLYLATHIASSVDLESGGTEGEPAAKKAKQSAMSVDDAATFHANAFAQTVLDMNNECHDTHHPIAVMKTYEEQKDAALEKAADFRSARMPKFFKHFEDNLKRSKSDFLLESGPTFADLCLFQVVDGLKFAYPKRMAKLEPEYPKLMKLYERVKEAPRIKAYLGSERRQKYSMGIFRHYPELDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B093</accession>
    <name>A0A2S5B093_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B093"/>
    <dbReference type="STRING" id="741276.A0A2S5B093"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="157"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="337" mass="36407" checksum="BC233514A11D7E16" modified="2018-07-18" version="1">MTACADQWEPPTPRSHLVPLPEPTLPVNHLVLLPPPMLPSAETVARLAERVSQSVANHVGTQDDEQRSRVSQWSAGSGHPQQGQSDPQDLEWFPVEPAPKRPRRSAAIVAARNIPRQPSPFDLTEEGFEDDGGDEPDPSESMSPPPTSSSRGGGASKRKVSHSLIERRRREKINDCLAALRETVPNLREEGERKLARAKERGRKRGRGDDAGERGGLHKLEILQGTIAYIEDLRARIDALEHQPASPASPPSPTSAQKQPSKRPPELAPLDVAPSAISPLPPFSASLGEPLNSMRRSTSLSLASSSGSGSGSGEVDDHEASLLLLNFSTSPELRPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0F4</accession>
    <name>A0A2S5B0F4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7923 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0F4"/>
    <dbReference type="OrthoDB" id="2524069at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="3">
        <location>
            <begin position="147"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="424" mass="46848" checksum="79226CED12869CAE" modified="2018-07-18" version="1">MVIQADPQSLMDGLGVPSSGQDAEEASPNPADVVDLSLTRFALQPALASSPNKDNLQAQLARLQLEAQHRGNNSRKDDYRDRIQALRGEIEARKDDLLDWAEQFENTEAVVQERQTRLQELEATRPTLRPGAEGDTGDIHQRSLGPPFILVLIDASTAPFNEDAISRGFSGGIEMGQRVRWEVEKDLREHNIDLDDGDNDEPLDTRSDAPPAILTFVWHNRKALVYNLQQNRIIRSEDSWDAFVAGFQAEPNNQVQDTGELPIDQFMAKMLRTFGRCKNLKRIYLAGIHLETLIEACPEIKPQNAHPFFIRVGPKMVLINHRETDDQREVLLGFGARVATFLRYFSSDNGLGGDLGWAFRASTPPVGPGDQNLEEGDDPNGYAPVYNTAQFSGAGSWAKTGGSSGARSRAGRAWLGGTTSQCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0X7</accession>
    <name>A0A2S5B0X7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000118">
        <property type="protein sequence ID" value="POY70405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0X7"/>
    <dbReference type="STRING" id="741276.A0A2S5B0X7"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="835"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1192"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="841"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="979"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1224" mass="130497" checksum="21579CD9FD301B86" modified="2018-07-18" version="1">MPPGPPRSLDSSGELPSPLPTTFGSDSATTDSDAVNPPQDYAKLVRTLEQRSLSRSSSTPTVHGVRGGSAAAAGAAEGSAHQLIEQDLRLAAQIGQSLLTEKAALQTRLEQSERANQKLLERLNKAVRENAAFERRLEESLGNLDQADSSNRALLVSLEEDRKTISRLSHDSGRLVAVSATLKQLQIAHADTLEDLAAERKRADAAETRARKAHDRAEDLDERLRKACSDLEEMRQDKVLSAKRSSDALALLKARQAAATDSDATQAAGAHAGTDQTQTRELMRIVETLVEENHLLRSESMELHGLLEREREDQELAREENGFLSALGIRTNGDDAREEDEFEVGTETDEVPRRRSGFLPRRLSGSSVFSHTSPRLDQSQSSFANTSSESRPPAVRTRSGASAGKVPVGRPRSRRTQSMDVTAQIRPTLGITSVPSSPLRGEQETFDRSTSFFSHASEDVDNSLSSSGRTKRRHRPLSLSLNSSVFSNAPSTAPYPDAEESVLVSPFTRPNGHRRQSSQASFQYGLASPRAEYAPGRSMRSPRPSPSRRSSVVERVDAATQTSPAGRGRPTRTASEDQDRPRTPAPVGDCPSCDGLTASPASSSAARTRSQTPGSSRMPAEMRTAALGQLIEHSSKLLARVQAADIATQEQRLRKQHLAGDVKHLAQANIRELAQDIDNLRDRFRRVVELERAAQHKDSQSAASNSSGDFSLVTRRDFVALVKLLRDLLSETSRLRLLVNRVQLEPPLAYKLRELDAPASVTPTITVEKTLGQSASSAATTLLAPISRLLGGQAAEQPSTSDSVRPSLAQSRRGGSSTVSTATVNVEYGGGAVRAAESVESPKSQAVASPRDATTSVGRPRQVRRELSSIFAGASYNSTASRRTTPAGVRSQGIDMPAQPRAVPTNRFVSAAASAASSYMPFGRILASYRPAMSSTANAVIDSIPHAPPVLDSPFDDDDEDHSPPSTLLERQLRPRGLSDSSIRSSFTTHGGFSRPNPHHRVVTAAGLALSAETKPVPMIVAPGDSSLDRSGERDAAIAAMSSSPASLGAAMNALRQKLEEDEAETAHALAEGKTISRRASRAQLRGRTSTSRLRESSTLAVSPPPPVPPLPDDLRLSTSTATSDSSLTLPCQTSPSSAITIDEVPAPSAAPAPAPISISPSSRSGSVGPKEKEGGTTSLFGMVVSSAFGSLIGSGSLGGGDKRASTSGSHGPADNWKDRNRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B107</accession>
    <name>A0A2S5B107_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B107"/>
    <dbReference type="STRING" id="741276.A0A2S5B107"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="976"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="909"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1161" mass="127376" checksum="31C380F7BA27BB19" modified="2018-07-18" version="1">MPPRKRLKSTTPASEPMQTRSKSRGASASSNASGSTSTAAAPQGSSSSSSRQRARAASADTMDDLDYGDSGSGFEYDSDAVGYSGAGSDDVEMTPTDQLEQEPHGDAGEGRSAQLEPIVLSSDPELSLEPVKPKGKLTSRKQFAADVAQLGERYKDDGSSPVSGLHRDEGEDMIQLALKHDGFPRGLKLSLCFPELSGYPNTHEVLCFAGDEDIPADVQAAIEEVAHLPLQADRSLGGIVGILVKRIVRGEANPWAKPATKVPSQSQQQDSDEEYEVDLYDAGTNTAQGTALMAALRASAFVARSDFKALLDQGYQPGFTRISELDLVVSVSKKVNLLGVPARALQAWDSGLITGKVVYLVLLMNFSSTYPVDLDNQTSGQVQFRVGISPTYKPSRDAILAAFRAHSSNPYTPGDFDAISLSNPLNALMNDKFQQIVQTRRSNDRVGWAGAEQHCLATGVTGTTVNKKSARAADKEEKDTSEANASLLPKDPMTSAKTANNFPLLAFSYLVRRFVMCPRFCLNCFKRCDQVITALKPFVCDNPLCLFQLIQLGLGPSLEHEIVTNAVAVDLLVQLTYIAAKEGGLKGELLPIGLELQVPRAVSTTGETDDLDELPNEEQRRAGIATLILELPPINDMRAWLLGENMTADERMMRRTRKLVDMRDKSISPSAWRLLRFIVASNTSYLKQIEEEDELVQGVPAEYRQFRFIVGDPAKEHRLAESIKTAQQIDANAVAYPTLYAWHGSSVKNWHSILRQGLHFKDVINGRAYGHGVYFAIQGDVSLGHYAASTMSSWKNADFPISKIAALCEITNRPQEFISSSPYLVCDKLDWIQCRVLIVQRNNLLTKQDEQQAVAAADTVAKAQKPQVKTVPLDPKFKLTLNNVNIAFPDVGDKLQRLEDELNDVPDELHASDTEILKEPVAPSPSKRNGTRSTSRPKAGVTSTEEEEAIDSFEPADEKRLHLLKMLPPPKNPNRVALATIQKEIKAMLKTQKQEGPTKAGFYFDPERSQDNAFCWIIELPQASFDQDIPLAQDMKKHGVKSILMEIRFGDNFPHSPPFFRVVHPRFLPFIHGGGGHVTGGGSICMDLLTSDGWSSVYTIDAILLQIRMAMSNLEPRPARLDPSTWNSPYSMVEAVAGFKRAAATHGWKVPAELDHFERQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1R0</accession>
    <name>A0A2S5B1R0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import receptor subunit TOM7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1R0"/>
    <dbReference type="STRING" id="741276.A0A2S5B1R0"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="6242" checksum="9A1B1BCB0FB1398F" modified="2018-07-18" version="1">MLGFVGLSDDNKERISKAIEVAKTIVHYGWIPTILVVAWRASNPRPPIMRLISPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1V3</accession>
    <name>A0A2S5B1V3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1V3"/>
    <dbReference type="OrthoDB" id="2528188at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32991" checksum="D3D7202E6D8E7D13" modified="2018-07-18" version="1">MLLVSPIKLFESSFAAGTIFALALVCALLDLAIVGMRSYAFHLLQDWARLVSVEGIAYSVMLAIMWHILLLMLLVDVFITLLSPSRDLQEGSVVSLSIVSIMQLPLTALFLKWETSPLTSRVLLGACALTAHSESCDDWWSRVRVVSITSSSAACFLHLVLIVIALRYVHIRAETPQEYYIKRGQVDAVKPIKRKQEKQSRSATPAQGTTERHHGWRKARKGSATGHQGKEQRKGRGKYGPMPYGEYSWSSDGDVPTSSATPFAQQGAGSAGGPSAYPPYAPFGVAPVQTDSEEDARARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B204</accession>
    <name>A0A2S5B204_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B204"/>
    <dbReference type="STRING" id="741276.A0A2S5B204"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="55"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="149" mass="16936" checksum="DE4C2F6BE0AC9B50" modified="2018-07-18" version="1">MAPKGKAKKETAPDESAADKLKPAQQLKLQARRACRHAARQSERRRNRPELTQNEPGTQLRHILCEKHSKSQQAIERLQKGEAFDKVAADLSEDKARTGGALGWMTRTGMIGVFQEEAFDIPPSEVRRPIYKEIKSKFGYHIVMVEDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B285</accession>
    <name>A0A2S5B285_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B285"/>
    <dbReference type="STRING" id="741276.A0A2S5B285"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="121"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="538"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="10">
        <location>
            <begin position="717"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="354"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="842" mass="91349" checksum="1DED914BD356ADA0" modified="2018-07-18" version="1">MLTRNTRTALKQLRSPRLAATSAPSPAVWLAASRAFATSRPPAYPPRPGGPPPPGGPGGPGGGGGFPIGNIFGGGQKREPGQALKDHGVDLTALAKEGKLDPVVGRADETKRVIEILSRRSKNNPLLVGPAGVGKTAIIEGLAQKMAAGEVPESLKGKRLISIDLASIMAGTGVRGSFEEKMNNLIKDLEDASDVIGFVDECHQILGLVQYIPRTPGASQMLTEVSVEQGKAEGSLDASNMLKPSLARGLQISGATTLNEYRQTIEKDAALTRRFQPVMVEEPSVEQAVTMLRGLKPKLEVHHGVTISDAALVSAAVLSQRYISERFLPDKAIDLVDEAAASLRLRKESPPEELDALKRTITTLQIELSSLGKDTEASATERRAAIEGELETLKRDADGMERQWRSERERAEEIRKVREELEKRRFELEDAQRKGDYQRASELRYSVLPELEKKLPKEGEDAAKGEGEGARVTSDDVARVLSKATGIPTSTLQRGDRARLLDLEQVLSARVKGQEPAITAVASAIRLSRAGLHPGNRPVASFLFLGQTGTGKTELAKTLAAELTGTERNLITINMSEYQEKHTVSRLIGAAPGYVGFEDTAGQLTELVRRRPWATVLFDEFEKAHKDVANILLQILDEGTLTDSHGRKVDFKNTTIILTSNIGSDILAEDGATGPDGAVTDKAKEEVFARVQSLYPPELLLPHQLNRLDEQIVFNSLSPQSIAKIVDLRLSELEKTLNHSSSAPDRHISLLVEQGARDWLTQNGYEPKWGARALNRLINRQIRKPLAEAILRGELSNGDTARIRLDANGDGLEVVPIHLNKESDVKLAEEIAGEGDEAQTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2J4</accession>
    <name>A0A2S5B2J4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="9" type="ORF">BMF94_6012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000091">
        <property type="protein sequence ID" value="POY70985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2J4"/>
    <dbReference type="STRING" id="741276.A0A2S5B2J4"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="331" mass="37689" checksum="5158F126DDDDAB20" modified="2018-07-18" version="1">MACCSCSARVALRPSRILAPSARAVLPAASSSSFPASSSLPTRRSHSTSSKPVTPQDSLPHLEGSSYRGHVPINWFQRGLLTVGSAVMGLVDTHRHGESPLPQFHMVAVLSETSAPEHSLRRLQATLRSTPSGRAILRERPRITEESINVERLGQLPAGTFGKAYYDWLRRNKVTPDTRDPVRYIDDPELAYIMQRYRESHDFYHVLLGFGVSLPAELVVKWFELANFNLPVAALSGLFGPLRIQDRDERSSLWRTYGPWALKAGGKAECLISVYWEREWETPIHELRDRWGVERPPVGFKQWRDEQRRIRALKDEEEHHRRRRAPMQGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2K7</accession>
    <name>A0A2S5B2K7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_6099</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B2K7"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="19">
        <location>
            <begin position="688"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="18">
        <location>
            <begin position="1384"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1070"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY70921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1702" mass="192306" checksum="7CA7FC2D36AE6957" modified="2018-07-18" version="1">MLASVRSLRALQPRAASRSLASRSSTVPALVAARQNSHAFSTKAPLNASQSPDTFMNGTNASYAQAQFEAWQEASLSELFCPFSRLSFRFFSGRSPSAAISPSRTCGATLDKNSVHSSWRAYFEGLKGGLPSQQAYQAPPGLVPSLGDSIEGAAPVAIGTGGEIEDHMKVQLLVRAYQVRGHHIANLDPLGMNTFDLDTSTPSELTIEHYGWSEKDLDKEFELGPGILPRFKSAGTNKMTLRQIVETCKKIYSGSIGVQYIHIPNRDECDWIRERVEIPEPWKYDNEEKRAILDRLVWSDSFERFIASKYPNEKRFGLEGAESLIPGMKALIDRSVDHGVKSVVMGMPHRGRLNVLANVVRKPAEAILSEFAPSQDPNEEAAADVKYHLGANYVRPTPNGKRVALSLVANPSHLEAEDPVVLGKTKALQYFEGDADPASAMALLLHGDAAFAGQGVVYETMGFADLPNYGTGGTVHIIVNNQIGFTTNPSQGRSTPYPSDIAKAIDAPIFHVNGDDVEAVTFVCRLAADWRAKFRKDVVIDLICYRRHGHNEGDQPMFTQPKMYDIISKKPTTLQVYTEQLVKEKTFTNEDTEKHKSWVWGLLEESFEKSKDYKPTSKEWLASSWDGFPSPRELKENVLEARPTGVDYETLKHVGAKIGSVPEGFNVHRNLARILKTRGTSVTEGKNIDYSTAEALAFGTLALEKVHIRVSGQDVERGTFSQRHAVIHDQKTDETYTPLRNLGENQAPVTICNSSLSEYGVLGFELGYSLVDPSLLVIWEAQFGDFANGAQIMIDQFIASGERKWLQRSGLVMSLPHGYDGQGPEHSSGRIERFLQLCDDHPFIYPSPERQARQIQDCNLQIVYPTVPSNIFHALRRQIRRDYRKPLIVFFSKNLLRHPQAKSNLEEFGPETSFQRYIQEPEPEGFAKPEDVARHILCSGQVYYTLLAEREKRGLNNVAISRVEQISPLPYDLITPSLDRYPNATTYWVQEEPINNGAWTYVQPRLETAMRETEHHANRRVYYAGRGPTSSVATGSKKQHALEIQQFCDAAFDLDAHRVFGDQVAHKKGDFNSADQTSEHYDGQGPEHSSGRIERFLQLCDDHPFIYPSPERQARQIQDCNLQVRRDGSEIVYPTVPSNIFHALRRQIRRDYRKPLIVFFSKNLLRHPQAKSNFEEIGPETSCQRYIQEPEPEGFAKPEDIARHILCSVQLIARAEAEHTRRLASEPVTLHQAYERYLDRHGRPPPKGYDAWYYYARRNQDLRQTADTSFLPVDFFVNQLDEPRVLLPYGERTDLERQGRRSSPRNLRSEDLLLHDINAPDTPPAYEILRTVCSPRSAAQRAKLAEQPGTSPVVTQRYASPFTTPARLGSFITDHELERRSWCEQPDLRELHQTLIRPLSFSWTHQLFPIFSNSKIDGFNDILVPAWFHWYRKKPYREEDDVEWKGKANQMFWRGTNTGGRSEGLGWMGWMRSRLVSKVNRLVEWAHYDRVLLAGADNMTLSVTLPSSAINAAVADVAFAAPDHHGDATSLETQVTEPSFRFTGSGEVPFKTNYLYKAILDMYGTAYSGRFPAIMESRSAVIKSRLFIEALDDSLIPWFHYVPLSLRLSELYNLLGYFFGVAAVPRLAQEQGFGPPSERDLDSIRHGRAHEDGLFRIAMRGRDWAQRCSRQDDALVYVYLLALEWARLCADNRDSDTWSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2K8</accession>
    <name>A0A2S5B2K8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5939</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B2K8"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17998">
        <property type="entry name" value="DEXHc_SMARCAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="737"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1131"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="249"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="520"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="991"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1277"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="258"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="991"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1308"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1329"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1349"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1365" mass="148460" checksum="61A07213EC233534" modified="2018-07-18" version="1">MNGVPPGMQGGGGNDQDSYAAAGLYSGPRTTGMGKQPSTDSNGTSNGAMAPISPQEPQRKRLRRGGPSGDESAAEGPGSFSDHLQDRLAGVHVQSQPGSQASSTFGSAVPSVAPTPPYSGSAEPGSNGTMQANADQPMQGAAQQGQPTYASPQMGQQALGAASGQAAYNPQQAHQYQVAGASQTAPGGATIPPINTNHPGFQAFCTQVGGGRQFPLEKCWYAFSQYPNDMTSALQLLLDAKPVADSRPTYAAVNPSSGAQYGAAPQGPGTPSGSSAPPPMYAQQPQYAAGAPAQQGYPQHYQQGPSAVLRQGQVGTPAAYGSPAQPGALQHAVPAGPSTVPQQHAATLNPQDQAIAAAQAAAQQQIMRLSAQKLKGPTSNNPKPTAAEIRAANEYIFPQAKTGTAGMTDAHLRHYFQLIEEYRTGMISKDNFKALQQYVAVLQRKMWQQASPYAHLAGTNPAMYSQRDVYQSQQQYAQRQAGQSSTPRPKQPKPVQVARAHVPQTSGSILARQLQLAGSLSSSSKKKSTKKRAYASDSEDDGGDYDSAGSGDEYGSRESPQLLAKREAIAVEFFNTCEKDNLMELAGCNATQATLTMKLRPFASANDFRTRTRKQKGVGNNMMETYLDVIAGMGEVDKVLTECEQIGAQLNSVMGLWKSGAALSADTENSKPGASGSDEVGMDMVAISEETLQQRVDKSQDPRVREAFKDFIRKQPAGVPDTVTLKDYQMLGVNWLNMLYRRRTSCILADEMGLGKTAQVIALLAHLKATGEQGPHLVIVPSSVLDNWMREFSVFAPDLTVYSYYGTQGERHELRSELRNLESLDVVVTTYNIATGSPDDQKFLKRKMDFKVTVFDEGHQLKNSESKKYKDLMQVRAEWRLLLTGTPLQNNLQELVSLLSFILPDKFRDASESLRAIFKVTPGSQTNLLSRERISRAKKMMTPFVLRRKKMQVLKDLPAKTERIEYCDMTELQRECYTEALQRSRKALTSAEEDDLEALEEDDEEEDLAAGEDEVKPKRGRKKAVASTKLGTKANASSSAHILTDLRKTWLTQASNHPMLFRRLYDDKTLRAMSRDCLREEEFMDRNKDLIFEDMEVMTDFELHRFAQMYKHLNKYALVNDEWMSAGKIAKLLEMLPQMRKDGDRVLIFSQFVQVLDILEVVLDTMQLKYLKLTGQTAVADRQGLVDAYNQNEDITVFLLSTRAGGLGLNLTAANTVIFYDCDYNPHNDKQAQDRAYRIGQTREVKIIRLVTRGSLDENMLELATAKLQLDAEVSGGAKEGGEEAGADGSSIKAERQMKKSLLSGLKKQFERETKPADGDAPKKEEAATDGAAPAAAPADAAAAVDAASEPKEGAEKPEAEEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Q5</accession>
    <name>A0A2S5B2Q5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_5998</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="PJQD01000091">
        <property type="protein sequence ID" value="POY70971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Q5"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Q5"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="18">
        <location>
            <begin position="75"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="19">
        <location>
            <begin position="410"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY70971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="605" mass="64680" checksum="7B8104877F2CE955" modified="2018-07-18" version="1">MASPLRFRAATAATRATRAFSSSARTQTAKDPLAPPPGERLNRYSYMLTHSKTQGASQAMLYATDSIDQPKDLERPMVGIANVWYEGNPCNKHVLTLGTRIKDSLTKSGITGYGFGTPAVSDGISMGTFGMSYSLQSRDLIADAVETVGGGHWLDGMVTIPACDKNMPGVLMALGRLNRPGLMVYGGTMQPGSCGAGMPSLDVVSAFQSYGKYLEMGETEEAERVRLETVRNSCRKEGGACGGMYTANTMASAAEAMGMTLPGSSSTPTAYKEKQEECDLVGPAMLTMLERNIRPRDIMTRAAFENALVLTMILGGSTNAVLHLIAIAKSVGIELTIDDVQSVSDRVPFLADLKPSGKYVMEDLHKVGGVPAVLKYLLEHKLIDGDIMTVNGRQLGDNLDRAKPLKDGQDVVRPLSDPIKSTGHLRILKGNIAPGGCVSKITGKEGLTFRGKARVFDNEDDVTKAIETKSIKQGEKTVIVLRYLGPKGGPGMPEMLKTTSMVMGAGLGLDVACVTDGRFSGGTHGFTVGHVVPEAFNGGNIALIEDGDEVYIDAVKNTIDMKVSDEELAQRREKWVPREPKVKSGALYKYIKLVSDASHGAVTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Y9</accession>
    <name>A0A2S5B2Y9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="4 12">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALG13</name>
        <name evidence="14" type="ORF">BMF94_5977</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="4 12"/>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Y9"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Y9"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="191" mass="20232" checksum="302AF62E23E4135B" modified="2018-07-18" version="1">MVKTCLLTVGSTRFDQLVSAFLLPDSLESLSDLGVNHVVAQVGNSLLPPGYHLGTTALPGGVRLEVFRFAGDLEEQVGNADLVVSHAGAGSLLSFIRPLSTSGGSSPGRAAHRKLVLVPNSTLMDSHQSDLAEEMDKKGWATICWTPEDLPPTLRGLGKGRDVQTGTAQSAFPELDKGKVQRILNEVLGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B352</accession>
    <name>A0A2S5B352_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5496</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B352"/>
    <dbReference type="STRING" id="741276.A0A2S5B352"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="285" mass="30750" checksum="FFF2FEB36A666BAB" modified="2018-07-18" version="1">MAYNPQSSSTPLLGQLDGQISADDESAAEQGRSRAYDPSNSQSAGVSGSMQPPAARGSVNVNGAGSADANASIWQQSAHPVALFCLFFFRSAAIATYLLCGFFVSSYVFSTVLVVVLLALDFWTVRNVSGRVLVGLRFWNQVDEDGTSFWVFESRSPDQPANAVDAKMFWIAMYTFPLAWVLLLFVGILKFNISFLPIVMLALVFNVTNTVGYTYAVRTRSLSVRRVAQARNDTEGVAITLLQDRDAKRKWATGMAAQGMLGQVGGFGGSLVSGLAGQAFSRFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3A9</accession>
    <name>A0A2S5B3A9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3A9"/>
    <dbReference type="STRING" id="741276.A0A2S5B3A9"/>
    <dbReference type="OrthoDB" id="3355480at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="60181" checksum="93AD7B0BDAB82F72" modified="2018-07-18" version="1">MTGASNAARQLGPTEKSFYLGSRGDGPESGVNDMYLHIGVRARPSLLTRDRILKTWSAVLDAHPLLSAGVEFVDYEDISFRSCSSAAGTEALHPRTEELVAFESGRSASEIISSYLNGPRTLSDEKLSYLVISRPGSAADVAFGSAADHVDDEMRDFDFFLFSTHFLGDGMALHSTAGEFFRLLTAEQNDEISPSKRTVSLPVAAEDRLPIGLTNTRFGAGIARADYEKEQARQIGAHTFPRERLGPRQTLVPTVSYPAEKSKRILAACKSHGVTLAHSIFALAAVAYTKTAAPERRRPEMPLMLYSAVNIRPYLKPVKGSSDWYHLAIGFYNIILPSFFVKDASVARALFWHRAQSVKCQTTRIVKSPFLPTRTLLMAKQRETSSIRWEREADEQRARSIKSVENGLKELNVKQESDAAIAADHETEDGAPVTVESVAKVTSTSTFVPQTALMGLSMLGNLDGMYKHAEYSGVELHSLTTGSRQRAGALLLFAYTFAGKLWLSLGYDVNGFERGVIEKWWDALQCGIDGLLLDENAIDDVGSSRGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3C1</accession>
    <name>A0A2S5B3C1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3C1"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="349" mass="38392" checksum="AF5E42DE44561FCF" modified="2018-07-18" version="1">MVANDILIFNEIPKGKPVPGQTTVKKQEEFDLDQSLPDGAILVKTLALSLDPYMRGRMRDESIESYVPALKLHAPIENFAVVEVLRAGENAKFQKGQKLYGYSKFQNYSVIPKEQAESLRVLENKEGLPWTTWVGSAGMPGQTAWYGLKFIGKPQKGETVFVSGAMGPVGQVTIALAHAAGCKVIASAGSEEKIKYLREELKVECAFNYKTEDPNKVLADWNQKEGRPFSIYVDNVSGAQLTAALAHIARRGRIVAIGSVVDYHGEQHGIEGVFQVVAKELTWEGFLVLNRMTPELFEQFYAEVPPALASGKFARPKEHVTIGLDNGEAFAALFDSEASNFGKAVYSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3D7</accession>
    <name>A0A2S5B3D7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3D7"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="58231" checksum="EDA836910D604020" modified="2018-07-18" version="1">MLRTLLLAQRSRHVRVLSVEADQLLPPASASASSRQRAARDTAAHGAPTRGMSRRLPVVLTLTFSALFLLACGLALSPYGHRDTVGENSLAQRVSQPLRELLAAGQDALDATPFAPKRCGISASLRSEFGDDNFRLSQVHVGSGYRMQRFLEKAAKREKVTVGLLGGSVSLGHGTDPESGRRNKYGAVPHDEQWHQFVIRYLEQAFPSTTFDFRLGAKAATDSTFFEWCWPSLIGTDLDLVMIEMGVNDDYNTGFDSSETLLRSLLQLDSAPAVIYVDSFSPMTASAKPSILNAQDIQSTLSPFYDVAQISARPALLPAMIQDPTLAEPFFLGDERHISARVHRFLGSMVVGYLMEERCRLRSAQETGQDALWSREASLGKVPKVKMTESWDANATHPTQPPRCRVAGDGLEPIRASEDWSLFSWRYSKYYWEATVPQSAEVVFEVLVGEGSVGSVAVSYLRSRSYNLGKARCSVGGQEAVLDGNWSRSISIAQTTVIATNLPAGTYEVTCRTLSPEPGTEQLAFRLMGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3J1</accession>
    <name>A0A2S5B3J1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3J1"/>
    <dbReference type="STRING" id="741276.A0A2S5B3J1"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="467"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="612"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="834" mass="90063" checksum="7F74168F0DE9136E" modified="2018-07-18" version="1">MADEHEEQPVAKRQRLDHDSAASEAPDCATPAVQAAPAAKTPVAPAASTDSAEPETLVQSFFKSDATGLFGVLAGSIGKRAAHEDEVGITEYVTPDVQPFAGIIKHRFTDFLVNEVGLDGNVVRLKDIDGPRARKDNRQGEGAAKQEQENGDVARKEKETAAVEEGSKAAEAAPEPVSVPCLSPRSYLNLTGPCCQAPALWTTEAEAQMSPLFENVADKLAEFKAYIEAGSSADAKDKRTFVTQSIADKALRGKFHQTLREAFSSKLVSAHKESEPAGEAPAIEVSWAQTSGAGRNRKRGGAGTRGERGERPDYNSLPPFIHFTLHKTNKESHDAMSILSRYFNLTSSRDLGAAGTKDKRAVTVQRISLRRSKTMTTDDVWRAARTGTIAHGGGRGGRGGRGGRGGMRGGNQGWVDRMMRIGDVEYADSALELGMLKGNKFVVTLRDVETPSVDTIHASVTSIRERGFINYYGMQRFGTAPIPTHAVGLALLRGEWALAAALLLSERDGEQQDMILSRLLWKEGKAGEAARAMPRRAVAERAVLEAYSRGDRKDHLGAISSIPKNLRLMYVHSWQSYIWNRLVSERVKLFGVSTPVVGDLVYAGDAADEDVAADEEGEASVSTEVDAPAPVADPNAATPADTAAANPQLAHFIATSSVAKVRALTAEDIASGKYTVNDVVLPMPGFAVTYPAGEIGEVYRRVIREDGVDPDNMWRKQKEYSLGGTYRKIMHMPQDVSYRLLVSTSPNEDLAQTDEDRLLGRPAPQAREYREEDGPLKEGESLALQIELTLGSSTYATMALREILKSRTSAATQKSLTQAMEARLSTASETAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3J3</accession>
    <name>A0A2S5B3J3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3J3"/>
    <dbReference type="OrthoDB" id="2522644at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015639366" evidence="1">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="172" mass="18046" checksum="A3D189EAAEB6B6BF" modified="2018-07-18" version="1">MHFLTTIATALAATCAAASPIARRDGRAQPDTINPYVGQLVLPETGQSVARSGNFSFSYLPSPNSGTPHYGNIIHSVDVGLQGPAPIVADPYSYGSDAIAEVATGISLGGPGGYGNASIHVNPDQIYKTGTYYVIITEHQLPAYTAYADTYRVQSYNVSIEVTEAADSSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3Q9</accession>
    <name>A0A2S5B3Q9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3Q9"/>
    <dbReference type="STRING" id="741276.A0A2S5B3Q9"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="283" mass="31042" checksum="9778CE1ECAD6DE78" modified="2018-07-18" version="1">MVVRILMLPGYTQNATSGRIGGLRRALKDTAELVFIDPPHIVNMPTTDANKFDSDASAAPTSEADTPRAWWFAERSESFRTFKQYEETLVYLRGILEKQQFDGIFGFSQGAACAAILTALCENPQLDPVFAKPNEDPNVTWPPPPFKFAILSAGFFPLDPRTAALFDKPLSTPTLHVLGRADTIVGEERSVPLTKVFDDARVEWHDGGESLYFRAVFSRFCHHTPSKASWRRFFQSYMEAFDENGGGKAAALALPSPSASNDADTPNASGTSTPIPVDAHGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3W2</accession>
    <name>A0A2S5B3W2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3W2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="176" mass="19157" checksum="206109ED5CB72F54" modified="2018-07-18" version="1" fragment="single">VAGSAQILPLDPLLGTARKLGVAARRHHRLELQGCKVHLGTNDPRARLVLSRLYAIRLASATTESRDERDGADLAGSPLHSVSRQQGQARAGRKGQGGSRRQVEGRRIPVATFLHSLDFLFSPFSRLLGFTPRICILYSALPLSTLMQPLAERALAHSKRGRMQNESLLGPSLSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B452</accession>
    <name>A0A2S5B452_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000080">
        <property type="protein sequence ID" value="POY71548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B452"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="205" mass="21972" checksum="FD2271C22A1A331A" modified="2018-07-18" version="1" fragment="single">MVSPDGPIKGTSSLIGVALAVGAGVLIATGLNVQRLAHIRRDRHEGHSAAAPRSRPRGGRRSDPQQHPRTASEQTPLLTNAQHDAGEDNVMQRTGDRKGPRVIVAVTPGQPPPPARQSAASSNDRRRSRSRSQSSAQTDTERRRKPRTDKGFLTSPLWLLGFGLMNGGELCNFLAYAFAPPSVVAPLGMVTLIANVFLAPIIVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B481</accession>
    <name>A0A2S5B481_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B481"/>
    <dbReference type="STRING" id="741276.A0A2S5B481"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR GRISEA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="776"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="950"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="782"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="951"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="969" mass="101473" checksum="2C2DADD27B3E941C" modified="2018-07-18" version="1">MLIDGVKFSCESCTRGHRQNTCKHADRPLQEVPKRGRPPTACAECRELRKTTNSHRTCNHRKDVDEQPEVLLKTLPNGAGDLQSVELVRRPSSSVKSRSSTSAASVASTSAASASEDDLASIGRRKSVSRTSSLSRPSTAARDKKPHDLAHGHLADHPTHVSNAYSPYPHHHPHHHNQHMHVPSPLARSDGGSSGQRTGSNNSPVATGVPPVPPLPPQLSDRGPQQRQQHSPLRLAQSPGSSLPVVPKQEPLSNEALASAFFFRDFPPEARSSSHSPDTSQYGTPAPQGSSRVSSGNNSRERPAYPSPHDYTQAVKVETPAHHPAPNALYADPRTASFESLPGIDPAAAAYVLGTTSDAPRNGAAAPMYGEGDLYYPETGAKIPADDSAYETFSLTTTNGYVDYRNAPQASSSASSDIYELPPTDPAVYGYPLESVSSNAPSSYSGYESAASATGGAASALERLDLDFDLPKRTSPMHTPSAHSGPSIARPPPPDRVYSSASSSAASAYPPLPGEGVDMQTTDLDGILEWLASSTAAGGLPPPPPSSRGEPARHDSASSSVATWPSAPPSSYGDSVIGAGYNAGAMYGGGGGGWTSYSESSDARPPAMSSSSAAGSSQAPAAVPNGGRTGGITWADNRDASDDDDSQAGEENSAGERVPRRRERNADLEMLRTATITYRDASFSASASDSPDVGGAGAAWDSTRANSPHDPAAASATGAARYARGHAFAAFIGDEFDRFGLGGEFDDDDWFRQIGVGSSGVAGLGDLRSGLAGLTAGGAEGDGGEDDGYEEDDEASVIGSRNPFDGNGFGDGYERSPDHMHELDGDGDDDELGWDRDQTFGAGPLPPEPQSQSSRFDPTYDQALASGTQPAIATSSPDDPRDPDFRLESDDPPPPSLEPAVAQSIPLNDLRIDAEPLHATNADARDPVDVALEARSPASPSRLAAYLEQLEDSKSAEEAAHDRGAGMWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4B5</accession>
    <name>A0A2S5B4B5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4B5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4B5"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000003">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="102"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="361"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="631"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="760"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="666"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="800" mass="85618" checksum="E70EED0417E4577D" modified="2018-07-18" version="1">MAATAPAIGGTRAQFEQQEDFISFDASPPPPSATAGPSAGANSRKRRISDRHGPAAGTDHDDPATASGTRRLRDRERARSTPWCEDPGVDWHAHRSAVAQLNAEATAFVSYISPTPVEHELRLFTIELIRRTIKSKYPDSDVQCFGSVGTSLYLPGGDIDLVVLSPSMPSPPLKPSSSLLHRLASLLLTSSIAAPQSLVVIAKARVPIVKFTTRYGGFAVDLSVNQKNGIDAAVRVRGILEDYAYREEGYVEPGARDASKEAGLRIKGKGKQRDNDDSDSDLEEGESLAAAADDMMLGQRHPVDHGVARSLVLLVKAFLSQRGMNEVFTGGLGSYSIICMVISFLQLHPRIQSAQINPNRNIGLLFVEFLELYGKHFNYDQAGITLKGRGGYFNKHDKGWFRPQQPYLLSIEDPNDPQNDVSGGSHAILRVRQTFAGGFDTLTSWLIVRESILAAEANPSLVPLTDAALPNADSDPPSRGSQSLLGGIIGLKKPDLDARDAHERLYNDGVLQKLIKRTEGANGVEDGMMSRKAQKRAYQETKERAKRERTIARLERKVEEKEKKRAKREKKKELKKGSAAAATTVGSESGVRALVVQPLATAGAIEDAYAKEAALEGLASHDSGMGFIVDTLGAGRRAPPPAANDQDNDEDDSRYSLGVPAVARVAQQAGSTAASSRRGSPALSGPPGRYTHVTDDSSDSSGAEDGHADSDGDVVLGGGGGDFVRHDGIRPSRTASVESEDAVSDESAEVLATLVPAAKRPKVARNESSSEKRAASKAKAAKRAAFWGAKGPKTTSDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4C4</accession>
    <name>A0A2S5B4C4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 2-methylcitrate synthase</fullName>
            <ecNumber evidence="6">2.3.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.5" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4C4"/>
    <dbReference type="STRING" id="741276.A0A2S5B4C4"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="715"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="764"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="764"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="817"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="849" mass="89411" checksum="355EB470143723B1" modified="2018-07-18" version="1">MSLGDDRAGLPAHLAGGVSPLRSWDENDDIRLREALERGDGKKTWSQIAKDAFPDGAFGKVDCQARWAVLSKPRTVKGAWTTEEDTKLRALVAQHGSEKWVAISEEMRTRTGKQCRERWHNHLDPSIKKSVWTAEEDAIIRDLYARIGPKWAEMAKFLPGRPDNSIKNYWNSQQAREKRRRSRSVSSVASDQAHSAKSRATAAATAAAEAAAGTAGNIPPGTPAPPLARSDSSTSLSNVRFTPYGRASHGHHKYRSESVSSLSAFSAASADSFDHPYSPVENAAYVTPQTRMSRSLSFTGEALPQVNQASVATGMPFDPSQGYAAPQHFVPVRNDIGSSLYGPGYRRPHSNSSPPVPVGLGQYNYPGHGASSLQASPVSRRPESMGHLAPEITDAWSGSPLVQGTIITPSGRFQPVLARLNTEQGSPHSTIASAIRSGYDTGSPAARSTSSVGSFWTDSRLASPGDHSDPAAFGSYDFGPPVGQPLYDQHPPPVSFDSYTHEDGRADPTQHYMPFMSADPSHGPHISDSFSFPAQPYSAAPADITLAPQPTFSSPHMGPIGASDAAFLESAMSAPMPAFPTGPAPAGHSMPPHGLTLPSLAAANAVEDSDMRTATRANFRESELLMPVLQTPAELSPVGEQFGSSMVPPSASTTPLSFAQDMSAIPQTAAQNRRRAAPCLPQLPAGNLLSTGAGQAATPRSDQTRFAAQQLMIPTSMSLPQHERPHSAPRPVSTPTSSDFSAGSAGVVPDSRLAAAFHYASSASAQPPTSLANSSSSANCPAPSPTSTASHPMAKSYSSSMAELSARYATGLSLSREGASSALSSASTRSNGAGEGLKVDASGRAVLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4K0</accession>
    <name>A0A2S5B4K0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Small monomeric GTPase</fullName>
            <ecNumber evidence="10">3.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4K0"/>
    <dbReference type="STRING" id="741276.A0A2S5B4K0"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="194" mass="21649" checksum="5CD0CB7A0B77977A" modified="2018-07-18" version="1">MSEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVVVDGKRVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWISEVLHFCSGLPIILVGCKKDLRNDPKTIDELRRTGQRPVTPQEGDMIRQKIGATRYLECSARTGEGVREVFETATRLALLSTKGRKKSGKCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4K2</accession>
    <name>A0A2S5B4K2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4K2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4K2"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="102"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="272" mass="30121" checksum="1EDFD37B287450A0" modified="2018-07-18" version="1">MATARSRAVLRSLRPSHPANLTSRFDAVIASTPRSNLVRRLPTAQPVRTLSQSIARHRIASSQTVYSTGGSCPGCGAPVPPKLSPVCPQCSALLPPPPPATTYYELFGVDPPSFAIDTANLKRSFLTMQQKVHPDMFSGQGESEGWAKAWSGRVNDAYKALINERERAEYLLSLHDVTIGEADPVTDPDLLMTIMETREELEEAQSEDDVVRIRDCNKEKRNRVIDSLATAFSASAPDLEAAKNLVIELRYLDNIEQVCREWQPGKRLELQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4P0</accession>
    <name>A0A2S5B4P0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4P0"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="480"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="553"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="855"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1022" mass="110381" checksum="D8E3D15241E69C37" modified="2018-07-18" version="1">MSEHRRPDPSPSASRPPLSLHPSSNGNSPSPAISTTSTHKRPHAATDTPRASGSARKGKEKGNAAMANVAMDTDELGDSDDDHALGPDGQPRKKRSRMALSCKECKCDRVMPTCGNCMRRNRPEDCSWDVFQPANDAFLPATIARSTDLDALAARLAHVEAYLKTLPPNFAMFRPLPAEAIKAAEGSGNADGSLIPSTSVKKASTADDEGFSDTEDAALRVENGVFGNRALEAPGAAPSSLVPNRPALRTNNSAYPASSSRPGAPPARFGAPPTELTKALTSITATPTGASASLRAHLLLDYEVSTDMVTRAKNDEIERIMRTLPGREATAFLVERYFANVAWLFHHLHAPSFRAEVEHFHLMCDQGRQRDVDPFWLALLLMVICLALDSMHYSRSPLALRGDHAHATSGQEHVGMGTPLEAYSQEQLKALPERWFGASMRALKLAEYETIPRVRSIQTIVLYTQYLQLSSASRGQPSQLVVWLATAIRLAQVFGLHLLGSNPETMPPEDPAFPPGKNSLKREMAKRLWAVLVYQDWLGANGRNRCYTISPQHCDTDDPLNVNDSDLSPSTTELTAAPSSVLTDSSADRIHIAMARQVRAVFDRVELARDWSYSTILDLDAGFRLILDDLPERWTLAADEQEQEAPMQRFQRHFVLEGLHNRIFRLHRPLLSKAHKNPKYKFSADACLKSARAVVVSTHNMREAVSDVPYTYSHVLGAALVLFNDLFQAIDHDLSAPEIDSKIATLQLALEIFSSKPSSASLAAVVQQGNRILAGLFREEERRRTNRAAKMLVFAATGAEDRNGGADDDDEEQETFADILQRVARSLDTDAAPHRGTPPPTRNIPSKVAVRAGAEPVVGPSSGGPGYAAQQPGDAHSQPFDATLPYPTSLSAGLAFGTTTTDSLLSQPFTADFDWTFAHATAGPSGTGAYDYDLGLASLGLNLDNDLGLSTYDPDTPLMTAQPIPLGSTYSSGLSTATWTDPMAAVDPATFGGNVAAVRPGMSEADAAAAYWGSTGTGQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B505</accession>
    <name>A0A2S5B505_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B505"/>
    <dbReference type="STRING" id="741276.A0A2S5B505"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="313" mass="34003" checksum="AC461FCB0EBAE3E7" modified="2018-07-18" version="1">MPAADVNLDEVYAFAINLAREAGKRILEGSAKRHQTAATLDNPNTKKNRVDLVTETDQAVEAYIKDSIAQTYPDFCFIGEESYAGGERVELTDEPTFIVDPIDGTTNFVHGLDFVCCSIGFTYKQEPVIGVIYNPFLDKLYSAQQGKGAFLNESTRLPLTHPNPAPLASLGDAVIGVEWGSDRSKAIIEKKGKMYMRLAGDGKEIEGGVMAHSLRSIGSAALNYSYVAAGQLDLYFEIGCWSWDVCAGTGIAREAGGKVYGRGGKPWSPQDLMGHHFFVVRAIADAPDGSETGEQAQDRIAKEFFAAAEDWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B561</accession>
    <name>A0A2S5B561_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="PJQD01000069">
        <property type="protein sequence ID" value="POY71924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B561"/>
    <dbReference type="STRING" id="741276.A0A2S5B561"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="267" mass="29556" checksum="B7B1F6DA3F25B108" modified="2018-07-18" version="1">MSAPPSKEATKPVLFGFPSTDNLSQALATFVLKAQDEALKKQATFRIAISGGSLPKVLGKDLIGREGVPWDKWEVFFADERVVPLDHEDSNFRLNDEHLFSHVPIPRQNIHVIDTSKLDDPEAVADDYEKQLVASFVGSSSIAFPRFDLVLLGIGPDGHTCSLFPGHALLDEMDGWVAWLNDSPKPPPTRITLTYPVLNHSLRVAFVSTGEGKQEIMKEVLDNPNPKEGLPSSRVRPISPGRVFFFSDDAALKLVQYERTHFDAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B565</accession>
    <name>A0A2S5B565_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000069">
        <property type="protein sequence ID" value="POY71920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B565"/>
    <dbReference type="STRING" id="741276.A0A2S5B565"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015423180" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="7">
        <location>
            <begin position="32"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="825"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="394"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="8">
        <location>
            <begin position="639"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="879"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="906" mass="96320" checksum="92DC03EF967CB52E" modified="2018-07-18" version="1">MLPSGQYASSALSWLLLLAPLFPGSPSVGEAKSTRPAPLGPNALAHPQRIGIRIIQRNEAGPEKQVRRRTKRAKSATAAGLSEASSPSPPRWDDRFLLSFIGHDDEPITLSLRPSANLVPADGIRSVQRWRDDITGEWKSAESVLAREAVTAYEGWVLDQDDDVDRWTREEAAGVVRAGDAGRGWARIVVTEASDPAQDAPLRFQGSYSIGDEMYTVHPTERYLRTRDPLDPTPPRLLVRRKRTVANETDLPLYEQAYPPMVIVRDHDVMSEEQRTLALIKRGLPTSFGESATGPSCSHDQLAFNIDPAHPVYVNSHPMANATTPWFPFSPFADLGGDAFTPADLSIAPARRAYSPRGHVRYKRQGNDISGSNGQSSNFINSIGSTQGCPKQQKVVFVGVAADCTYVQDFSSPAAAREKILTDFNSVSALYQRSFNVSLGIVELIVQNSSCPTTSSQVDPNARWNVPCQSSSSGGSIGVDLNERLSLFSEWRGNKGARDGAGLWHLLTSCQTGSEVGVAWLGQLCRTSASGSAGSVTSGTGVTATTRNEWQVIAHEIGHNFGAIHDCSSGCSLSSSCCPLSSSTCDANSNYIMSPVSRGEVSAFSPCSIGNICTTLSSSLNTTCLADPGASGNPALISLQSCGNGILEDGEECDPGGVDDPCCNASTCKFRSGAVCSPRNSLCCTNQCQMASNGTICRPAVDSRCDVQEVCDGSSFSCPTDKYRDDGSSCGNGLSCASGVCTSRDLQCQNAGASLNLQSACPTSASSTCSIACRDPRSSRNCLILDQSFRDGTACGYGGRCRGGSCQSGSGLDRAKGWYRDHLNIAIPVTVVVGLLVLALLWCLLSCLCCRGRKGGFARNKPGRNQSYSNAYSNGGYYAPPPGPPPMRGGYGGQPVTRPAPAYSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5B5</accession>
    <name>A0A2S5B5B5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dithiol glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5B5"/>
    <dbReference type="STRING" id="741276.A0A2S5B5B5"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="124" mass="13553" checksum="BBC041C1C874305A" modified="2018-07-18" version="1">MLSALTRYARSFFTSAPVSQEQALAAKETVESLVRSPVAVFSKSYCPYCTEAKTILSQLGQTPRMKVIELDREALGGPIQQYLAEKAGASRVTVPQIYIKGQNIGGCSDLKKLQREGKLDQLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5H3</accession>
    <name>A0A2S5B5H3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5H3"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="359" mass="40040" checksum="7AF9BED573D6FDD7" modified="2018-07-18" version="1">MADPIPRDPWAQVALTRDQALEYLDRIGLPAATLSEPPSFDLLARLLQSQLEAIPIDTTPMHVSESLWDSQDPTAPIELSSALLDMPEGTDAFDRIARQRKGAFCFAVNPTFCAFLRAVGFRVSEVVGRAFKSLNNDPLSHPDGWKWGTLTHGLQVVDWAGSEKRYFVDAAWGPWSCPVPLALENGSTGLGLNPYEAFRLVKEELPLGPEQTRPIDTQPGWTMYRLIRPDPATASTSLSLPLPPDEVLRSQGAFWTPQYHFDLLSVPLLDFRLFHHFSASHCVGVFYAFFIVTRLLPGTGGARRSLMYADKPGMPRRAKVFTTGGDAARGSLQSRDVEWVDMQIGPMRNYLEKEFGFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5J5</accession>
    <name>A0A2S5B5J5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5J5"/>
    <dbReference type="OrthoDB" id="2527421at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="179" mass="19048" checksum="C3A5E94016B376AE" modified="2018-07-18" version="1">MFSFKFFTRKATATRTTLAVAAPVEVNEKALPLINEKELPPPPAYETVVVNVPPAYAPTALFPTRDAVGRPVMATKARRSIRAPANLDMSTAPHLPRPVQAVSRCVVVTSKSNVAGFTTTSDLGPVQATAATLGEVKLLLRLQGEQRKAYAVTDVVITSTGGEQPTLSAVGRAVRLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5L9</accession>
    <name>A0A2S5B5L9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GDP-mannose transporter</fullName>
            <shortName evidence="9">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4937</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5L9"/>
    <dbReference type="STRING" id="741276.A0A2S5B5L9"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="401" mass="43780" checksum="C9F65644448CF607" modified="2018-07-18" version="1">MTTPANDDKGAYKVVVDEEQESAYGASRSNSISSRSPPPSSQFDHLLNHPALPVLCYCASSILMTVINSECRDACSPVPPRLYTCRTDCLTPGSEYVVSGRYFNMNFFLLTIQSVVCVSCVITAKRLGVITFRDWDREDARKWFPISFLLVTVIYTGSKSLQYLSVPVYTIFKNLTIILIAYGEVLWFGGSVTPLTLVSFALMVLSSLMAASPDLLNWINGIEAPAKPGGQSSVGYAWMMVNCFVSAGYVLAMRKRIKITNFKDWDSMYYNNLLSIPVLVFFSILFEDWSAENLVRNFPEATRSSLLSLMAFSGAAAVFISYCTAWTVRTTSSTTFSMVGALNKLPVAASGILFFGDPATFANVSSILVGFFAGLVYSAAKTAASAAAKQNLPTELGKTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5Y6</accession>
    <name>A0A2S5B5Y6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5Y6"/>
    <dbReference type="OrthoDB" id="2536282at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="816" mass="89621" checksum="4234E094E299042D" modified="2018-07-18" version="1">MASSERTPLLAASPAASSGSTLSPSASLPTSPPPVRPQLYTPINSSADLILTEDDIAIQGMVLALLAELADRGYVVPPGLPTLPTDMPQEEADAEIAFLRTVFRVPRHRQALDRHLPDLTKAAVGGMMNGTASGGGGVGSGAETPPVGAGSILATNRPSAANGRKGGSTAPARPSPLSSQQIDTTVLTSPSALFLSALLSLLISLQREHHGSVEETDPGVDGELRMFKARRELGERLYAVVGGLLDSYLLTGDAKTNAPHRDDEYEDDDGDDALVTLLFHDFPLNYDSMDRATCSLDLLLMLSSAPLVEAEDLISHPVVLASTEYVWRNGLLPPPRAGLRALSWKEAFIRLDRFSVPRILQSQTYILSTLHAAITVYILMFSAYSHFDAFNPLAPDIITIPEKTTGRPVKGWSVLTELVWWLWVAGTFGWAGEVGRIWTQQGPQSSLPLSPSTLLPLLHHALVFVSLALRILAFYLATPHHRPTFLIASSLSLLAWSVPFLAASRVLPQNLPSFGTPTHQRWSKIRDGRRRRDVGYRAPPKKVPESHRALRSLEAHLGGLVQFSTYFAVFGLLTLWTFSGDVDYPRVMTALLHAPLEPLQQWFTFRDSVSASMTAGKRRSPLEARTSLAFTLILGLVLAYFAGGRPSVSQKPVTSLHPTAPRRELDDLDGWDRYGREVAFRARRERLAVNRYYTFLPPVGRRTGLGGRRLESLASAFSRPPLPSPLNLAIPPLLFVCAIAKRVIRFRLEQRRRWSNARGRVVDEDGDDVWPPGQEAERRVRVLQETVRLWIWRIGISPLGGWAVAAKGIRRLRGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B614</accession>
    <name>A0A2S5B614_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B614"/>
    <dbReference type="STRING" id="741276.A0A2S5B614"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF105">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="30"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="471" mass="50502" checksum="D43349BAA94744F6" modified="2018-07-18" version="1">MPIDAASWLAQNASSYSVLPRTGHDGEQTTPTARLVVILNAHSGAKMARELWQDVARPLFDYALPRGVAWDGLVEETREIGDGERIGRSLRSSAEGAGAREGLVLLIAGGDGTVHEVLNGLLLGEDGELDARGSERQIQVILIPAGTANALYYHSFPPESPSFPVDAPASPFYSLLSFLAQKHSSNAQHLCPIALALNSLPSTSKPSPSKQVLTTVVSSVALHACLLHDAEALRTTHPGLERFKIAAQQNVQRWWSGTLRLRGNVRKYSPARQAWLDAPTSTIGVEGPFAYLVTALVSRFEQSFVVAPFRSSSHPLAPDADDAPSFDVVCLRPLRHEPTRQKVEAGQERETRETFVQRIWDVTGGMYAGGKHVDSVYPPTELAQVDEAAAHGELETDGVVEVYRCGEAEWLPDSSEQDLKSRLVCLDGAIHDLGVPALDSSATADQQDGSSGLVIKAIGGASAGGSVSLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B630</accession>
    <name>A0A2S5B630_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4771</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000056">
        <property type="protein sequence ID" value="POY72195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B630"/>
    <dbReference type="STRING" id="741276.A0A2S5B630"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="387" mass="41691" checksum="46924CA83FABD764" modified="2018-07-18" version="1">MAGMGMPASRERRVRTPGFACYSLAFSPFYPNKLAVAGAANFGLVGNGRLSVAAIQDGPQQSVPPGQLAAAGAMADGMAIEKGFDTQDGLYDLAWSELHENQIATGSGDGSVKLWDIMLNDFPIRKWHEHQREVFSVDWSNTMKELFCTSSWDGSIKIWTPERQASLQTIPAHGACVYSALFSPSQPSIIASCSSDGSLKLWDTRTPLPATPAATPGQPALATAQLTIAAHPGSEILDLDFNKYDPYLIATASVDRSVKVHDVRAASSSPPAPPATSGIPHVVPHATVATLLGHEYAVRRVAWSPYRRELLATASYDMTARIWSVEAAGGAGHAPGMTTFQARGGMGARIERVWDRHKEFVVGVGWSLFEEGTVASCSWDQEVHLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6B1</accession>
    <name>A0A2S5B6B1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6B1"/>
    <dbReference type="STRING" id="741276.A0A2S5B6B1"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000002">
        <property type="entry name" value="ATP synthase subunit 4 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="231" mass="25128" checksum="9C001E2EABD0B7FF" modified="2018-07-18" version="1">MLRSAAARVSRQAIQPRVLAPVRSQSTSQPAPAAKASALIDALPGNSLVSKTGIVTLTAATTAAAISNELFVLNEEVVILGSFAIFLGYVSSLVREPYREWADGQIQKVKDILNTSRAAHTSAVQERIDSVGELKDVEGLTKALFALSKETAELEHETFRLKQQAAIAAEIKSVLDSHVRHEAQLREQEQRDLVQTVLGNVQKQLTDKKLQRDILLSAVSEVEQLAKNKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6E7</accession>
    <name>A0A2S5B6E7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6E7"/>
    <dbReference type="STRING" id="741276.A0A2S5B6E7"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="385" mass="41148" checksum="47F4B5BC37DAE46E" modified="2018-07-18" version="1">MKNVVIVGLGLSAAEAVKALVDKLPTEYRLVAITASEGYWPIASLRAAVVPGWEDKPVTSVDPIVPKGSRHLLLKSTSVVELREHSVVIDRAHSELGTEIPFEYCILATGSSYPWPCRPEAGASIEEIKTGLRKLQAEVEASSSILVIGGGPVGIEFAGEVAAMYDGKSGRSKKEITVVHGQDRYLMKDDGWKDGFNHSIGSQLDGLGIRTIFGTKVEDAPKATGKLAEGKQTFRLSNGQTVSADFVFLAIGNSPNTQIIKEFDAAAVNEQNRLAKVRPSFQLEGHDQIFAIGDIVDLPESKIFVNAKNHGGVGAANILSLIHDASTPTSCLKAYKSGPKIMIVSIGPKGGAGQLFGFVVGSWMAWIAKSRTLFVDAFQKTYVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7G1</accession>
    <name>A0A2S5B7G1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7G1"/>
    <dbReference type="STRING" id="741276.A0A2S5B7G1"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="71801" checksum="66B5D13362C25BD4" modified="2018-07-18" version="1">MQARAPDRAPESGPTVVAPPPSGVDSELLRLISSTALQNKLDTIVGPKTLILTPSLAGPLGLVTEVGLLKNNHAVTKMFWLEPGPLSQAERNVVYLCRPEVKYMRMIADQIRTTPDPTQHRYHLLVVPRMTSLCSTILSDLGVLGSLEIQELQLGLIPLEKDVLSLEYENVWRTVELDGDTSPIYDLARSIMTLQRAFGPIPRLIGKGDSARRLVDLLKRFRAEQPSAMAQGAPLANGVIDSMIVLDRQVDMVSALCTQLTYEGLVDEVVGIKHSHIDVDPNLLNPPPPASTSTPTQTSMNVPTPRKRKHLLSSSTDQLFSELRDQNFAVVGSVLNRTARRLNEDYEKRHQAKTAAELRQFVGQLGGLQSEHQALRLHTNLTEQIMGLTRTDEFNIALEVQQNLIAGVDLATQENSIRDLINLEAPLRTVLRLICVYSLISGGIKQKLLEEFKRDLLQTYGFDYLPLLLALERLNVLTRAQPSSRSAPKPPFAQCRKPLRLIVDDVDEQNPQDPSYVFSGYAPLSVRLVQTAVTPAGVANGVSRGSNSLNGWRGIEEIVRALPGATFDERQKADDMAMQRLSSGEVPTTVVCFIGGITFAEISALRLLNRQLPSRNLLIVTTDTITGSSLLTSLTPEPLRRAGTVSARESGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7N0</accession>
    <name>A0A2S5B7N0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7N0"/>
    <dbReference type="STRING" id="741276.A0A2S5B7N0"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="212"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="343" mass="38347" checksum="856BE379AC24105D" modified="2018-07-18" version="1">MSPQLALEPLQSPPSASAAPAAAPPEPAKPAKRSQAARSRAGDSTATKATAKKRARLTVAPDETTQVTRLDDRYQLHLADADAYYVPDLVKPETAQAWHDELLNLEECKLPASTTVQYSTLSFRSRSTRMLSPLCYRAPARLFYPLAYVVTGYRPTLKVYGRQVTQSRQIAAFATDPDLQVKYSGTEVRMSYVYPPLLREIQDLIEAKLGVKFNHCMLNLYENGREFGAEIYIGNHRDNRENRVIASLSLGAPRTFILTHDKPPPAPSEPKAEPSAPPNLTSDLTLSDLADPPPLRYSHRFVLENGSLVVMQGTMQQFWKHQVPKEKKVDKSRISLTFRQLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7V9</accession>
    <name>A0A2S5B7V9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7V9"/>
    <dbReference type="OrthoDB" id="2529591at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="321" mass="33560" checksum="A549BFECCE7A07BB" modified="2018-07-18" version="1">MSGYQKLPSEEQPDFAEKRLDDNKDEQQQRQQPSYQGAYVRAGMVTAVSLIVLCALSILCAGGFNHPALVHPTAFEKAARLERLQSDARQAARGLIKRNSLVQEAPESASPTFSSLTTTDQQGEPTTQSFVYTTRPIVNPGGYTIGTMTGYVQIKPTATASATNSSSPEQPTSAGAGTTPQRLPGAYVIAAAKAAAEAADTEGSSPPVGARLAKRDAGVVGAAAAPSTTEPPTALPVTTTGTGSAEYSTSTDRAGSVYTLVKTTRPIVNPGGYTIGTLDGAWVDVAKQTQSASSANRDKRNAAAVVQHEELRRRNVADLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B859</accession>
    <name>A0A2S5B859_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B859"/>
    <dbReference type="STRING" id="741276.A0A2S5B859"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="921" mass="97734" checksum="479ADA727904BCBF" modified="2018-07-18" version="1">MLVSGAGRSVVAAAARAGARAGSCRSASAAAATRRTVRPDSEQTDSYQLADKVKQLVLASTRRQKSTPGSQSGDSLSPALHLIRTAPTRAATVVVWNVLLNSILTTTSSHAKPSDDAQAVQRAYQVWMEMKRRGVVPTSRSYGTFLTGVAKRAKRAARAQQQQQQSGCTVPPDGWNADLRAKVETVHKQWRTHCERVLERQASSLEGRSRREARGRAAAPADSDGDDALDGKHDSPESLSAVPTNQYLSFLSASLDLCSGSVKAPFGGSTPPPAAGPLLSHLVQTFEGMPDPDHPDRNGLARLGRTSVSYAIVWGALKSALRLVDAAAAAASIDPEATGQEKRREIDDGLELLSIGESASPTPPTVEALPTTQQILDKALALWVHLVSHPPTPELPSPSHSSPSSSAESLSPILPTALISLYLSLSLSASASIPPATHARFLSLPQVAFGFVPPSRIADLEPPHPPSLVEPLCGSSGAMDHAAFGASLRLAMRAAPSAGVSQGATWTRSWWDQVRDYPGRFGLARGFGQDDPVSSSSAPPLSGAVLGEEALRDREAAEVVIKASGRAGDPEAIEDLISYLRSTVATRPFSCSRSHAPLVSTYILALSSLSRIGTQAALTSAIRIWNDLLATEPPFVPSPARTSSGQALEKVGVAKAAYAKGAYELVRMAVMGVKERTAVWAAVKAVSGLEAGRASSSSSSETGSTAAASLAVAATHGAFHPLNFPPRQASGDSAPRRTGGGGDSKRDAELDQLARILHNAIGRILSGDGRPGDLSSQLGSETVKVLEEWRGRIKAFAGIADRGSGRGLETATTATTDAADGEMAWRRRETVKKQAARERTSAAFDGARPRSPARSPYSRDWDDRDDYRPPPRRRDEGDRRHSPTGRPTYSEDRGPARRSQPSFSSSRPSSRSHEERTYRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B861</accession>
    <name>A0A2S5B861_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B861"/>
    <dbReference type="STRING" id="741276.A0A2S5B861"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="25"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="348" mass="37089" checksum="8CCD8F48D937B638" modified="2018-07-18" version="1">MSWSSAAAASQIPTQMRAAQIQEQGDIGVIQVRQVDVPKPGPGQVLVRVEYAGNNFIDTYQRGGVYKVPLPYILGNESAGEVVAVGEGVDEATYGYKVGDKVAAYTAGGSFAEYALTSAGKTVKLVDGISTRDAATSLVQGLTALTFVKEAHEVKKGQYILVQAAAGGLGLLLVQLAKRFGATVIGTTSTEEKAEIARKAGADHVILYGPGRDVVSEVYKITGGEGIERGVHGVFDGVGKDTFDSDFEIVRRKGTIVTCGNASGPVPPFAPLKLGPKNLKVCRPVLNQYVHTQEEFQSYAKELFELVRNGDLKLAVHKEYDLSTEGIRQAQEDITSRKTSGKLIIKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B893</accession>
    <name>A0A2S5B893_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B893"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="524" mass="57337" checksum="E21F3DC1DC0E7845" modified="2018-07-18" version="1">MSEATAPAASPAAPASSSVPVPMMMTSKAPSTASTAPAAASRLPNELLKSILSEAWPTESTLRQDVQTQLALGLVCKTWYAVAESLAWESIEVDAEDARVVDFLLSPAGQRVSALVTELELRTSKPNPPRADSEPDDEEEMAHAGDDDKESERKKEEPPPKVDEAMADKLATIALQCQALQTLKATYDTEPVVRKLTAHASFETLWPDLRNIFLHLIGEFWETLPILSAFTQRDNIKQFVLRLAASDETDVDPDGLKTKRAIEQYPLRPLEKLEYLMVECWAIATIALPAVFRVVSPRAPLVSVQTSGFAPTADFFRALGQGMSELTTLRFSPIDVDDDFKLNVLPNLHLLGLRRIKSFSFTFGPSRHSTSVLLTFGAPEAMPGAGEFFKSLPLGIEATNALSDTMGLGFATPFRADDALNEIMARPPAPVLTIFDKEHCEMIYDNKPLLQKVFLHATSLPGQRTIFARFGELVDPDNVSEWVRVDQTLIVDGAGRPYKGKGNAAKEEEEEEEKTAGEAAAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8I3</accession>
    <name>A0A2S5B8I3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8I3"/>
    <dbReference type="OrthoDB" id="2525012at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="715" mass="77385" checksum="FB73A30B13772755" modified="2018-07-18" version="1">MTRPIPVSGQRQRRSKSCMACRAIKTKCKGLSEEFLHLVDDPDALAEAYPAGPSTHPRCERCQKNNVECAFAPSRRKGRPRRLPAGQQPQGHAAYRSGSEDAHKQQRDSDASSGIEEPAEGAPSDRRRTTSTSSKGRHPYHGTEAGTRLPTPEHSQSTPSPPALSSLAAFQHSREASAASAGFSSSSRPVSNTSASASPASYGGPGDHYSFPEQLAPTGLLTPPTPNLDSHLVLPLASQPLFTHSPLSVSAGSSSSDHVAYSSESPATTTATIDDEYLGHLHALAVRFLDEAYEWVPFLPSSHDKLVSYLACSRPVLTEAIECLLDPRSGRPCPCVDWLEGPGTSAGRAGLAEPSLADLQAATVLSLLAFAQRERSRSVELLQFACRNLLARGWRGEATRVDDPLFTRSGLEDARMLMDLGWYCWGIEVQLGIITGQRASILSPLVPPPAVLDRTTARHYSFHVAFLATDYAHLWSLDTDGERCAYLRHVLSLVQAVHTVCVDTLREAQLPPYPIQLNSTRDRALRQDLVLGAMLALAGGILILSSASPLSPYVAPALPCSLDTTDRPAPNSRHLHAIARSAKGIVGLVEEFGTTYRAEDVGDGTGMLVLRKVSWPETIHHPFFGCCLVVAARGLLILTEDLHHEIQAATRPVWLAETMTEAARADANAAQVELQRIGNQLDLCEGFLRVQATRWNASEMLANEVSLLRRTANFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8I8</accession>
    <name>A0A2S5B8I8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIID subunit 8 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8I8"/>
    <dbReference type="STRING" id="741276.A0A2S5B8I8"/>
    <dbReference type="OrthoDB" id="2529901at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="474" mass="50764" checksum="5405C95B18C7F5A1" modified="2018-07-18" version="1">MAYPYNPDLHLDDDDEDLDLDFDDASDASESGSSSAPLDDSVQADDDHHHAADSKDDKPPLPAAIPAIVLHRIVAHALVRAGFEQADADALAELEGAVAIFGSLLLYAHDLAEHAGRHVPTVTDVLQGCLDLGVGRVSHLLDELDRTDSLSPSEGEEILRVRYQRPRAAVDPGPLLASDDEPDPCDASNDPDLASPPPTPPPLPNRGGGPESDEDEDDDFEEVTPVGPDGLPLPPDSDAMKLRREAVERKKRERAEKKERLARDKEDRRKERERRRRERQRRREADPLKAEWLPALPPKHSWKQTPVYPESAAPPPIPPPISQTQQAPSTAALQHLSTLRARLNDSQLVAASLRNLIRRTRASGLGAGTGTLGLVVGGEQGAGGGGGGEADSADVVDYESEWYGARGGAGPTGAKRKIRVVTVGRSRGPGDMLDLEDEGGGEPGLSDGLRKGGGLPGTNASRVGGAVKRRRWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8J2</accession>
    <name>A0A2S5B8J2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8J2"/>
    <dbReference type="STRING" id="741276.A0A2S5B8J2"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="303" mass="32758" checksum="DF8ECE4A76C2AB4A" modified="2018-07-18" version="1">MSSPSSDGSIEGDVLPPAGGELANGHGDAVPLAEPLVEGPSHSTTSATPAATNAGPLDDFDTSLFPAPPVFYHRYSDANLALPLDSVIADVPGEPKPFSRRELEPPNVEWIVEDGSYSVFGETWPVEEKTPTLAEMGVPEMFDRTHDRKVSLQTLLRTLILTYTQLLDALLAPPPSLAYPEPTLPDGRPAPTDPERLTEHMRLICFNMHYLVNELRPVQARQTLKLMMRSQIDLRRRKTIAVKQKCAEITATLASLQSDALAVAGAEPTRSRPLQPSPADAAAKAADEALDIFAKLRAKAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8S1</accession>
    <name>A0A2S5B8S1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein rhp7 treble clef domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8S1"/>
    <dbReference type="STRING" id="741276.A0A2S5B8S1"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="777" mass="82415" checksum="032B1E983F58630D" modified="2018-07-18" version="1">MPPRRRNSSQTPAATGSPRQGAVYGPRSALTSFLREQGITGAQPQFRPRTGQRLTAAAAATDGDDDETTRVTVTAAAAQGDDAAAAQVTTADPTNANADAGPSNAVTPTKRTAAATSDSDDSKVAGASKKAKKAASKKKKAQKPEGVDDHGFSLGGSALPAPVPKQGRYESRPVGSFAVCAECGKKFTVSKYTASNPKGPGVLCQPCMSESIEERAAFPGAKTSGGGGGSGASTPNKQRPKIQKKRSQKGVDETLYTPVVTLQQACLSIISQYIRDVDQLGDLGPKNLDKIAKIVSKHRALDDANLKLFLDVGHRELKLYDCTKITDSALGSISTFAPHLEALTLLQCGRLDDDVLDAWMHPRTGFKELRNLTLYAPYLVRTAKWKEWFEMMGEGGAEGGGDRRPELETFQLRMSSRFDDSALEAFVKHNPHVVHLQLSELGKLTSDSLALLHPLAHPDSLELGAGAGAGAGQAASEPVLRSLDLARLGTPQGQVLQDEAVIALLSHVGPSLERLVLDGNIHLTERTLTEGVRRYCHRLRELSLSDCEGIGGDGVEAMMVGRWPGEEEAPQASGGDGTAADGPAMDTTTAAGADEAGSSAGGAANDVEMDGVAGPAPADETPTADAANPNANEPNAHGGDDVPLFEPGKPWRSPGLTYLNLHRITTLTPSALSAILTHSAHSLRDVNFHSCDELDGDALYTLAKRAERIEILDLSFVRAVDNFVVQALLDQSEKLRVLFLHGNNRVTSDVPRKRGVHLRGLENAFYTEIPAGVPWEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8S5</accession>
    <name>A0A2S5B8S5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8S5"/>
    <dbReference type="STRING" id="741276.A0A2S5B8S5"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="416" mass="42220" checksum="6DB0EE8B9EB532C7" modified="2018-07-18" version="1">MATHRPLQNLLSTTGSSPATRSSSSLVTPQLGALADPRVYTADSRLLNWLIAETINTLRESEVAAANRQDRDLYAAQRHVESLRLSPSSGATDSSARPHTHESSPVQRTEPDEAAVRARLDLIGYRVGWATAERLARDRPRFPLATAATPAPTASTTAPPQSTAAAPPPPPPPQQLDILELVKFICKDVWISLFDKQVDNLRTNHRGVYVVSDNAFASLNGLSPVSVSVSVSGPTLALAPGAGTLAAGGGGRHQVVDPGAAEEEEERKQLHNHVEAVLAFPSGIIRGALAQLGVPSLVSGTADLSTLPQASFQIKTGAAAFPPPAPPAPRPALNAATAPTSGAARPAIPSATATGTAVGGGGGGGGAAVVASTGPPAPASAGSSTPRGGTPVVPPPPSSSGSLPPAAPTTKTLNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8T0</accession>
    <name>A0A2S5B8T0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Theta-class glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8T0"/>
    <dbReference type="STRING" id="741276.A0A2S5B8T0"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="115"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="271" mass="31082" checksum="BCCB790341AACABE" modified="2018-07-18" version="1">MTTFNRAALDKGPKELQNKGLVLLTAQTPNGNKPAYLLEELKAVGAISGYSFIPTSFKDNEQKSEWFEAVNPNGRIPALLDNREGKEPLRVFESAAILMYLAKAYDTDFRFHFKDDDLETEMISWIFFIQGGVGPMQGQANHFFRYAPEKIPYGIERYQNETKRLYGVYEDHLTGKKDGEKKEWLVGGKYSLADMATEPWIRSANWAGLDINEFPALKDWMQRIEDRPATIAALKIPEQDMRTRMKQDPDLEKKVMAESSAWIMKGNQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B917</accession>
    <name>A0A2S5B917_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B917"/>
    <dbReference type="STRING" id="741276.A0A2S5B917"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="486" mass="54578" checksum="BCF729988761D261" modified="2018-07-18" version="1">MVPEDELPVLESLVHIRNRLTALKKDRTEYIRANDVLDIYASLMTQVTRLNEVRATPKPATTGEAKDGDDADDIDANAVSREPAVEHEENRVDTILNDVFQLLSLFFLRIGKSREAPATFCQLGTMKRLLTHLNESGIYTEADLKPYQSRLAELKQIIEEERNRASSNPDAAERERDLAMTALLLAKWDACDRLVKKLASSLSQLANELYPIHQRLITLRRLLASIAARPRPAAADVQPILAELRAIEDKRVDGKFVVDPKPKRAGDGASTPPAAPGPIAPEKGQALLAGLLQDNFDICEDIKVREGEDVVARGPLQPIYDRLSEIRAQLERLVLTHRWTLRETDLYNYQNELSRVDALRKDGKFRDADGNVPEGQMVLLYLLRRCYGLCYRLMASSEPVSEELMPIANKLNTIKRCLIEVAKQGGPFTARDLYPFQLALYQIDSLRKDGKFEGRDGSIPEGQAILNALLSEAHEMISMMQEEGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B949</accession>
    <name>A0A2S5B949_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B949"/>
    <dbReference type="OrthoDB" id="2525367at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="121" mass="12782" checksum="87CBD09EB85D8799" modified="2018-07-18" version="1">MTFFFTHSHFSPYNMSTISKTEAHAGAGDAGEGYQAPQGGPRFEEGKENSHQALDSTDERSIANRLAAAEKAEKAASDEGGNAYAGVGAAEAHGNKPSRGAQIDAELQKEEEELLAKKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9M6</accession>
    <name>A0A2S5B9M6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9M6"/>
    <dbReference type="STRING" id="741276.A0A2S5B9M6"/>
    <dbReference type="OrthoDB" id="3270176at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="295" mass="34073" checksum="4AAACB4EB87E2A78" modified="2018-07-18" version="1">MKTPGSKQQCALCELPAVSRCGGCRNMWFCSELCQKTLWPVHKTLCGGDPRYFRQAPLTDKELRDVEAVKETDACHGDCGCDHGVNFRENMCAYPGVGTWENARKILQSSPKILEKPDPRTDYRELCLLDVRRKLREVYSTTDRERVATPWIEIEWYFNTANWALTRNRQPEYSRAEEMQMTAVAAQALNDWLRQAIIYCQVADLGMKHASMMVQFSSHTWVRLVCVHWDRLDKLLDKLLDEAKITARAKEEKRGQMTQKRNALENMRQPRLMFWRGLARHPDSAEAKSSGLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9S7</accession>
    <name>A0A2S5B9S7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9S7"/>
    <dbReference type="STRING" id="741276.A0A2S5B9S7"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="889"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1110" mass="124233" checksum="A7293F6C54468FA3" modified="2018-07-18" version="1">MDDLFPNLQGFTPRASTSKQPAAGFALDPALASTGGTTAPRQALGGRGEDDAYWDDDDDAGDGNLFDSTTGTAPRRRASVASSNDGDDDDDEDDEDATESETDAEDEYAAATQGQGRARGTGGGNGKGKGRAVDHDQTFRLDEQADEDLDRLISAIRESNSTQVGGSTALGREFDRSIADELDAFDPEMMENLTVGVKGRKKRKGGRNRGRRAAADVEPSPEVKRLIGQANQAYAEGSLDTAVELLTEVVRIDPIIKVSWYTLATIYEEKGDQEKAVQCKIVATHLLGKDQAATEWASLGRECRQIGLIQQAIYCFTQAIKADKEDVDTMWDRAVLLKLSDAKSMAIKAFTALLTVLPHDPGVLRQVAPLLADTQQYARATSLLLAAFAYYRSACPVVTPDTVERLNTYGYSDLEMLADFLLAQRAYKEVVRVIRQGVRWLQGREKESGWDQMLDDREYDEERHVREGWEKGDAYFEDEPTYELDVRLRSRLGLARLGLVQLDEAQHHFEIVMSEDVAQFPELFGAIGEAFFERKMYDSALEVYHAIAESEETNGPTVWSKIGQIHQAQGDYEDAKECFENVVEEEPDNMEAKLALAKCLEQLGDPSRALLYIKEVIERRQAREDATSEGADGKRRNRRYTTKEERAAARTTQENAERERHAEFILAFSKLQDLDTAVAAGEEEAISRYLEIATGLIDSFRSTRQLFPGDFRKKFTGVLSSYRGRRGRKTQAQQMDDEADMMANRLERTMIAEEDNEVEEHTFRGLHFDEWVSFILKYCFLLASIEEIELAADVLLHVREAGVFRQVEARQNALRWGLIACYHRAGMFEQLVAEFRHFLLVYPSQTEPLRLFLALVSKGQSAIEAFNGTRLLKFAIRQLKLVQVAATGHSADDGPKTGAARGDSSPIVDRKGKGKERAVNQDAAADDGADDDDEDGDRLPEHGHAFKPTKLSPVWFAVYGMMLHVSQSYQPAIIYLLRSYEIDKKQPLVNLTLATAYLQRAMTRKTDNRQHQIAQGFAFLDQYRRLRGPCPETEYNLARAFHHLGLQSHAIKHYEATLDMIARNDEMAVDDETRIPSDLSLATAYNLVTLYSMSNLPDLARGIAETWLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9V8</accession>
    <name>A0A2S5B9V8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGT1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9V8"/>
    <dbReference type="STRING" id="741276.A0A2S5B9V8"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="101728" checksum="F15047C71B02A353" modified="2018-07-18" version="1">MATRPPYEAQTDSCTYEIDYPSRRDSPEALVEACARVLAQVGSLSSDYIWHKQAFQLGLSPESFAHPVDKPQHRYLQGKTDVTDAVDDEWFIVWLLRQLTILDDDAAVQIEDDDGEFLLIEAADSLPNWVTPQNAANRVWIYRNRLHLVPLEHKSALPFGTDDKASPSFDPEEEGFLDRATALELVRNDQVNTLAPEEVQDAVWARIDGYPAKIREHHHRTLAYLPTEIALALADSPKLIAEAVGAFYERDPTMLKSVNSMSRFPPSSSAANATSTSTATSAAEPDAMTDDNTSPTAALSDAVLVPTLLTRPLYSQLVLQRFYAPKPFLKAGWVEAKRGRDDERWRDLGMKIACGFEMLYQQTAPKVRHPSSGTTGDGFDTTEPKYRAYLKSLADKGFFGDEVEGSEKWKGQEQVAREGWLRAKTSRPTLSFAQRVDEAIARARSQPDPLSERIDDPSALTADRLAELEDSEDWLSLDEQGLESILSARSSRKGAMLGDSDLEDSSDEDEDEDGYEDDEDRQDGMSGVEGGKSAQEKLEEKKARKAAKRLEAMAGKVQDFVEGRGAVSGALFDDEQDEDDADADSDDDESDVTMPEMTAAERAARMEKLVASLPAEQWGQKPDEVAKAAEAGVAAASAPSLEATGDDATTNQDGEPARVPRPPKLAKEEYEGASDLEDDSEDEAMPEGEEGLGGSDVEGEEGPSVMNEDDMLDLGEEMDEFLKFATETLGLSEDQYAKILDERRGRGAFVPGPAKEKKVNVMPSSSRAKQTRFAAPEEPSPAAKTAAGNPPPPRERLRNPNLTDFDSLMEQMEKELAQARSSGRPAGVTSSTPAGASARPSRNSDKIVVDSLSDSEDDDDGPGPDPRGEDISAMDAELSQLLKGLTGGGKEGPMDYNLVKNFLDSFQSQGGFAGPAGNLAGRLGFPLPRDAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9Y1</accession>
    <name>A0A2S5B9Y1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9Y1"/>
    <dbReference type="STRING" id="741276.A0A2S5B9Y1"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24020" checksum="BE208A14576B771A" modified="2018-07-18" version="1">MQRTLQTTTRAVRATVGPSRAALSSSSSTLLLRSLTTTSSPTSTRRLAPHAGRTAMRAFSSSPTQKSAADMTNIIASSPDDYVSVVSLTPSAGFTLSDGLVVPSPILMIDGNCFLWDVDHPTVGSRPDGKPKSDLGFDWNGWSKDKLAIFETLSPRPEIVLFGTGQKGLFAPPAVRTYLNGLGIQVDVLDSRNASSTFNLLQEEGRRVAAALYPVSHLSARTGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9Y5</accession>
    <name>A0A2S5B9Y5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Endopeptidase Clp</fullName>
            <ecNumber evidence="4">3.4.21.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9Y5"/>
    <dbReference type="STRING" id="741276.A0A2S5B9Y5"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="179" mass="19241" checksum="9D9848A33EBFAE8D" modified="2018-07-18" version="1">MSSLAASFARLTLQARPACRQPLARAATASSPFASTSRLQLPYTADRAFSTSRPAQATLNQVTRGARKPVQRQNKTPALEGCFQKKGVCSKVYTVKPKKPNSAVRKVAKVKLSTGRAIIAYIPGEGHNLQEHSVVLVRGGRTQDLPGAKYKIVRGALDLNGVAGRAVSRSKYGTKKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA22</accession>
    <name>A0A2S5BA22_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA22"/>
    <dbReference type="STRING" id="741276.A0A2S5BA22"/>
    <dbReference type="OrthoDB" id="10011777at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11882" checksum="DD4E6D0A82A515D7" modified="2018-07-18" version="1">MADQAPSSGKIVVFARAVAKEGKADELQRLLQEAVRSANSDKEPYTLTYRCARHGDEFRLFEEYDQDIEQGIKSHMAQEPFQNLIKSGLTKEVEIKYYNEVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA30</accession>
    <name>A0A2S5BA30_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA30"/>
    <dbReference type="STRING" id="741276.A0A2S5BA30"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="87" mass="9745" checksum="A96563B964662E51" modified="2018-07-18" version="1">MASELRYTANTQTAQLHARYTGTGHADVTKYEWMTHQHRDTSSSIVGHPALLQYLSIADGESTARTKFELTERMLQPCGPPPPKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA47</accession>
    <name>A0A2S5BA47_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA47"/>
    <dbReference type="STRING" id="741276.A0A2S5BA47"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="722"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="828" mass="90277" checksum="5640C5546BB01A5B" modified="2018-07-18" version="1">MASTAQHSASESASPRASTSRERHDEPVETKPGTDQLRQSLYGDETDDAAGHFPESNGDGGQPYGEETGDVKKGGGKRSSAATGSVKLDENGNPKKKRKQLVACDSCRLRRVKCDKADMHGGPCSECIKKSITCTDTYVKNKPKVVRGGKLIAQAKKLYGGQESIDLDRTPHDGYDEGSGEAYLPAPIGQSAFDRSAPQRSLMMNQLTPDVSDHLIRIFSRVFQPQCPLVDEEYFLKAWEAAGRNLADLSPALEVLALAMQASRLSRGAWAARITDHVSVIGSNGPTLTELRNGAGRDFTMVGKLREGFAKSLLDRAIETVDRRAALRTASAACCSALVLLEFLVTWDDVARKSNLGRYLLSSACEHLRNLQLGECDDPAEPLVPPERASNGTLLWMVYTRDALGAMLGGRSCAFSDDDLNSLSDLFNSPITTDVISYVSSTDPKMLSGLAVAAIFRYSVSGVRNTVSRLTGPLARRQRLNAQVVHDLWAQIDECARYGAIFRQSVDRVTFGPEAPKTDVWFRDLTAMKSQNTLGIHLALCARLREEESKQQDDVDYLNTLRHLKQLSDNRLFRAAREYCHVLHGYGGNLIFAATVTPEYSAHYLESLVDMPSWEQGGPSDWPWNVKKSEVAKCIDVIQLAGWCWPGYDLVVYHAQCSMKRQHILLDQMEDSRAAADMYNGSLRTSYPHQRDEGSPYPPQGWTLRGGDGGHVQYASYSVDQAHSYTSSESRSTAMSQHGPVPPHDGHQDQPIPASNGHPAYGAGHRALPPLRGPPAQAYADHHSGADATRLPSLTSYRPSPPGPAPTSSTCASLPSISAYAQAPPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAA8</accession>
    <name>A0A2S5BAA8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAA8"/>
    <dbReference type="STRING" id="741276.A0A2S5BAA8"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="743"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="950"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="950"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="970"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110943" checksum="D9D774D64B153CC1" modified="2018-07-18" version="1">MATVPDDPIPPVLGEDGQPLSPKLSERYNEDVVLFTDKDGKERRAVVTRCWADEQNPEAVAEAARLGVPFTPLPAGYLEVLLPEGTRAQVLESTTTLIDKGFLRGDIIRARRAAGASTITPRGQLGQVVDLKTEVQLQRVLTGDEIEGWFPATDLVAASRINHGDHVVHGDWIGVVEEVFEMAMIEVGNNGIVRRVCDIGNTFSVGAATDTIKQMLLERGEGLLAAFLGATDFKRILDVKQCLVAVNWLCRNPQAPQSSDSAAWDRPKRFWTDIDQLTLVHAAADHLHSINDKVVFRDASLHPPAPSSLSETYRDGFRVLAIRNCRTTLEILWQDGTHTTASSTEFEQVAAVDEETDVFPGDVGVFSGVSPSKIGVVQSMDAKKRTIRLRYLDAKTCLLDPTDEEETISGLEFDPHGPPPDAYGVRRGDCVLLMPESETNGVQAPIVPGLGESEIAAGLMPAGEQLRIDLTSLGMSYCQTLSDSFVPPKAQEAPASLRWYGEVWNCLLSGEVEIRFPCGDKAAVPVPRIVHLDDGLDPEAGMGPMVGEDGMILEEEEDDAVSTDRSWETEDDADDGASVDEGEMSLDQDGVVSLVQGTFGEGEDDPEDSDFVMKDADGKPVKADEEDRREGDRRQSKRRRGHGPSTAQDEVKGWADEVDEPSIAAPSTSEAAATADATTAAATVQDAPAVAAAADDSVNAPTAVVSMPTETSDFEDWSRFGVLEEAPEDHHYYSERVLAPSKAFMSRIRKEHQVLATSLPPNILVRAYENRSDLLRCLIIGPLDTPFQNAPFLFDMYLSPQKFPNDPPQVYFHSWATGARVSPNLYVEGKVCLSLLGTWSGDQTENWSGARSSILQVFVSIQALIMVEAPYFTEPGFEKHMGTPEATAASELYNERTLVLTRAFVKRACEYPPSNFGREIAAYYYTGLPGASGGALQGIIDQSRRLLQESEEWHAEQEKKEASDSEGGADTTSPPKSTVVPSQRILTEGAGLSLRRTVKALEQLMERGPKLDPESEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAC6</accession>
    <name>A0A2S5BAC6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAC6"/>
    <dbReference type="STRING" id="741276.A0A2S5BAC6"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF247">
        <property type="entry name" value="GH16156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="62596" checksum="F794E4B86A6B778E" modified="2018-07-18" version="1">MPPKRSLSTTGGSSRSSRPSKRYRALGIGAPSADDAAASSPRLAQAQALAERAGGGASYLAVRPVRQGVKSLKETSLRVAARGLYESVRMPPHQKQATPSHNVGWDPGRDPERSEEAQYLRTFIRTLPVEIANRLLRLVLDLTTGTSFDDPADPGVAVLSLAMLFFHPNTTRLSLSGMAAPTLLVSRIPQCTALAELDLSGHVALRDPILAKVVAQLPTLEVINLKGCTKIGDQTLVALSKASEDRLRVVNLSLTAVSIKGLTSLLARCKNLEVLKLANVQGLNERNVSKWITDATDAALGWRHVPLSQLRTLKVRSTEFTDASIGRLLSLCAPTLERLDVSYSNLKTLDFVSSALHTLPEWKLVKLVASGLPLTPATLQGFFDPLAGRPDEERRRFTTLKLGSLPASSTKAPGLTDAVLAKLMPSLEKLDGLEKVSLFQNWGLGKLAQPLSRFVEVIGRKCTYLDLTLPVESHHLEGLLPPLEDDAAEGPVAYEPPRIQTLVLDSSRITDEAAGAISACRDLRSLHVAETRISTRFLSTVLASCPHLSQLNLTSCRGVPVTQRRTFFEAWAKGEVSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAM3</accession>
    <name>A0A2S5BAM3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multidrug resistance-associated ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_3360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BAM3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001354">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1106"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1156"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1238"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1291"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1345"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1369"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="326"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="727"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1121"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1435"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="427"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="973"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1693"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1001"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1052"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1080"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1698"/>
            <end position="1712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY73819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1730" mass="190432" checksum="A0CCABC6BE855DE0" modified="2018-07-18" version="1">MLVFLLEQLHRRPDRTVPVPAWTIHLAVAASAVIVSLAVLVSNSQRQRAQLGAIRLPTTTEEERRDATLVEKDSESGVAEFYPRLRRKKLATLAVVAVLLALELFRVGWDSLAVGPNGWRNWLERVGMVVPWLSVLALAATSLVVEHDDQASPASALASIEEHWRLTVTAFVIAAVSLFVALIRLIVPRSAGISLVPSPALPTSIYRADLALLITSTLLQLAVVLLFGSTRRCAPLVHATMGKEIVAFPSCSPLSYILFAWITPVLKISYHVDVIGEDTLPTLSAADRAKNGWERIRASAHLMDEAPKGWNPLLWRIVVVNKRLFIWQIILSSMNAVLYYAPAFFLQKLVHFLETRQDRASRGDVSLHWGYVYCVGLLVGSVLEALVSGQLWFVSNSMLSTRIRVQLNALIFNKTLRRKDVSGVSNTRTRASAASSDDDDAESDSPAKDGATASDDSDESEDGDDSKVPVFKSKNSVTNLFAIDSERVSDFVTWSSSLYDAPIEILIGTVFLYNLIGYAALIGISVAVFFLPLNNWASRNFTVTQDRLMATRDKRVSLMNEVLSSIRMIKFYAFERAFEQRILAARAEELAALRYNYFLEVSFQGIWTISPILCVLVSFWAYTSPLLMHQTLTPSTAFAALAVWNELRFALNVVPDILQSALQSLVSLRRMEAYLRMPEIDHLPPVLEGEGDLPPSIDPRPEDEPPVRFDHATVTWPSDLTKAEKQAEAEDETLEQVKTFELQDLTIEFPKGEMSLVCGRLGSGKTLLLLSLLGEVDVLDGSVTCPRSSPAAIALPSLDWDSYLTEENWIAPSNVAFVPQTAWLQNASIRNNICFGLPFREKRYRDTLAACSLLTDLEILEDGDQTEIGEKGINLSGGQKARVSLARAVYSRASLLLLDDILSAVDAHTAAHIYEKCLKGPLLAGRTVILVSHHVQITAAGAALVVSLSNGRVAFQGTAEEFLESDGYKAVAGGDEDEITPMVSDGKKPPAARKTSSALVPPSASRKSSSASVTPAAAAKSKPRSFAQVAAQATGYESPSAYSTDVTSASEGGEDDSDSDPTIDGDEPKANGKLLSSPPEPEKKPRKLVEEEGRAVGRVSGAVWKLYLGMMGGILFWFCFAVIFAGAKLSDVAQTWWLGVWAGASDNPDQARSTNYYLVLYAVLSVSAVIIETLQWFVLYSGTLRVSSKLHERLLHAVLRAPLRWFDSQALGRIVNRFSKDLEGIDASLPDNLGRSLMYFLGVITTLTVVASSAPTFLIGFAVLFVAYYHHAKLFSHSAREFRRLDSVSKSPLFSVYSEAIAGVAVIRAFGSSARFMALMLERATTNVTFYWYLWGTNRWLSMRFTLLSALVVGLTGYVLIAAGDKMDAALAGFTLTFALNISNDILFLVRRYTSLELSMVGVERVKEFSEIKQEAAEIVEPRPPAHWPQGHIEVKKLRIRYAPELPDVLQDLTFSVKAGQKVGIVGSTGCGKSTLAASFFRFVEAHSGAIVVDGIDISKIGLLDLRSRLTIVPQDPVILSGSLRSTLDMFEQYDDAEIFDALRRVHLIREEENPDQQAEDGANRSVFWNLDAEVAEGGSNFSTGQRQLLCMARALLKRNKILLLDEATASTDHETDELITQTIRSEFSDSTLLVIAHRLRTIIDFDKVLLLDKGRLIEYESPAKLLDDPTSRFYALCRATGKKEFAVLKRMSQGKSRVTHKPRKLVRRVSSRLKPDGPNGSASVPKEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAV2</accession>
    <name>A0A2S5BAV2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_3064</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAV2"/>
    <dbReference type="STRING" id="741276.A0A2S5BAV2"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="429"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="528"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="626"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY73894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="769" mass="84650" checksum="4F092ACC9CB75042" modified="2018-07-18" version="1" fragment="single">SLPGIASYQLITRQDAVPGNGRTGRTNSGNVGSHRHLENHLRPAWTRAHQDDTSSLSGARIKRKARETDGGCRALPLPLAPLHCDAPSNSSASHLAQEVPSSRAPTTSNAELDRWRKTFYNFATRDTVDDGEVYLTPPDFVAAVAPEGDFAKISREQYALLFKVADRRKCGRVNFDDFVAFEEVLKKPAAEFDVAFRIFDQNGDGEVKFDEFKQVFQSMRGPDSIPFDFDSPWCTLYLGKANGGHVVGFNEFTQLMKGLQGERLRQAFRYFDKNQDGYIDKGDFRRIIYELARHKLSDTVLNKLEDLAELFNAGKISYSECIAFHNVIREMDLVEKVVRESCARSPDGKITPLDFTNHASRTMRYGTFSPMEVAIIFHYARHGLSPEEKPRLGVRDFGSLLDPKWGPPGGAEPSKGKSTAAGGAMHEIGKSAYYFGLGGIAGALGATAVYPIDLTKTRMQNQRSKVVGELLYKNSLDCVKKVYRNEGFKGFYRGLPPQLIGVAPEKAIKLTVNDLVREYATNKETGRIKLSWELLAGGLAGGCQVVFTNPLEIVKIRLQMQGENAKVTGAARLSAAQIVKSLGLLGLYRGAAACLARDVPFSAIYFPAHAHLKKDVFHDGRDGKVLSYGEALAAAAIAGMPAAYLTTPADVIKTRLQSEARKGETHYKGITDAFRKILHEEGFAALYKGGPARVLRSSPQFGVTLVAYENLKKHLPYPDPNQSISLTELVMPKEEDLARVRARNALKVLLDVDTNVGMSTVLAQPSKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBF3</accession>
    <name>A0A2S5BBF3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBF3"/>
    <dbReference type="STRING" id="741276.A0A2S5BBF3"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="210" mass="22798" checksum="4B4482EB67C70EC9" modified="2018-07-18" version="1">MESYPLSYAEATVHLCLFEVSNAAELRSRLVTASQLPDDDRGDEERAAVDFAFIDAKMITSRLHALTAVQQALLARSDGTLKTKTIHSEVLWMLEPGSNISDSLKHFGLSASTRHLLLVHIGSANGGDAAQERSAAEGVWRRMEAIVEGKAISLEQLGRLPDGGTDEKGIRKTYKLNQDAVFKNLPLGTPEALEVLDRLTTSTVALKVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBX1</accession>
    <name>A0A2S5BBX1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBX1"/>
    <dbReference type="STRING" id="741276.A0A2S5BBX1"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF8">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="4">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="660" mass="73310" checksum="8DBA64DE8D44A74A" modified="2018-07-18" version="1">MSTAHLHRRVCYCPASAPANASAVDALSSSASESRHRQLGTILYRGPVPPAKGEWYGIEWDDASRGRHSGTYDKTGVQYFQTRVEGAGSFLRTDVKGLDVVGKCFSDAVAERYLEDETETGARPSAPSSDEATALGSVTGPDRVSKVERHATLSNFDIEVVLNDRVTNRFKDLGRLREVGLEWEGVSRAARSAEKDGYESAQQRELQQFGQQMRSLEGLNLSFSLLPTVEEVDDIVNVLPKLSCLAINSNCFHRIEKPLTLPGFERLVRLELNSTLMTWPELRRVAPSLPNLVDLEFGFNRLRGLTLEHAKEGSMHAIQEQQLLPKLERLNLASNELESWDDLIEELANLPRLTELVLDNNRLRDLAYPAKGLSQQSATTSPRFGDASSDTRSLRHLRHLRQLSLRQNMLSSWKTSIEALATSSAAAFPSLVDLRVANNPLFDTASRPSESGDRNSTPDFGLPAADEATALRREADTRLLVIARLPQLVELERSPVHASERVDAERFWLGRLAQGHERLEDLSDWARERVRTLEKEHPDLVVRRSDPGSEGQGQAAARTIKSRMIRLAIKISPDDFPKLSSAAPVELSVLPSLRTLILRTQIARSLGVPIPKTKYRLVARLQPAEGGSEEIEVEIPPNEEGKEVSWWGLQDGDTVEVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC34</accession>
    <name>A0A2S5BC34_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_2524</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC34"/>
    <dbReference type="STRING" id="741276.A0A2S5BC34"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000628">
        <property type="entry name" value="Pre-mRNA-splicing factor RSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="14"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="460"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="858"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY74330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1203" mass="131963" checksum="54F194A89FD62B61" modified="2018-07-18" version="1">MVHLYHHSLIPGGAITAACVGNFSGTKQQEICVARGAERIELLRTDANTGKLESLIEADVFGQIRSITAFKLTGGTKDYIIIGSDSGRIVVLEYDPVNNAFNKLHQETYGRSGSRRIVPGQYLATDPKGRAVMIGAMEKSKLVYILNRDAAANLTISSPLEAHKPRAIIHSIVGVDVGFENPMFAALEVDYTESDQDPSGAAFEQAEKLLTYYELDLGLNHVVRKWSEATDPRANLLVQVPGGQNAATDRFDGPSGVLVCCEDYIIYKHQGAKEHRVPIPKRAHPLADPERGVIITSAVMHKMRGAFFFLLQSEEGDLFKVTIEHEEEEVQALRIKYFDTVPVATSLCILKSGFLFVASEFGNQRLYQFEKLGDDDNETEFSSTDYDNYGAGSDPLPPALFRPRPLENLAVADELESIAPILDAKVANYLGEDTPQIYAACGRGARSSVRILRQGLEVMEAVSSELPGAPIAVWTTKLKAEDQYDAYIVLSFVNGTLVLAIGDTIEEVSDTGFISSAPTLGVQQLGDDALLQIYPRGIRHILADKRVNEWKVGGRDTIVCATTNSRQVVIGLSSGEIVYFELDMDGQLNEYQERRPMGAEILALAIAEVPEGRQRTPYLAVGCADSTVRIISLDPENTLDSLSLQALTAPPSSIVMAEIVDASIDKYHATLFVNIGLQNGVLLRTVLDPLTGSLGDTRTRFLGSRPVKLARVPVQGQPAILALSSRPWLNYAYRGILQFTPLIFDALDYAWSFSAELCPEGLIGIVGNSLRIFTFPRLGQKVQQTAIDLSYTPRKLITSPTNRLLYTVEADHRTFSPSSMQKAVADMRAAEIDFDEELLALDPKEFGLPRAGAGEWGSCIRIIDPVTAESVFKLDLQDNEAAFSVAIVNFHSHPEETFLVVGTGQDTSLAPRACKQAYLHTYRLLDEGRRIELHHKTEVDDIPTALIAFQGRLLAGVGKALRLYDLGKKKLLRKAENKGFSTMIMTLNSQGTRIIVGDAQESIYYAVYKAAENRLLIFADDTAPRWTTASTMVDYETVAAGDKFGNVFLNRLPQGVSHDVDDDPTGSGILHEKPYLMGAPHRTQLIAHYHIGDIATSLQKVSLVAGGRDLLLYTGLMGTVGVLIPFVSNEDVDFFTTLEMHLRSEAPSLCGTAYTPVKAVVDGDLCEVFRTLPMTKQAQIAQELERSVAEVTKKLDIIRATAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC61</accession>
    <name>A0A2S5BC61_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="3 7">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="3 7"/>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC61"/>
    <dbReference type="STRING" id="741276.A0A2S5BC61"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="266"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="665" mass="72307" checksum="A394264D4981E2CA" modified="2018-07-18" version="1">MDESKMQATAADLERALVDSLVEAAMPTSTADDNKIAHDATTGQAQVEDNANEPTYQDGDLPDFSDSEETATTTSDSKSTPFTRASSAGGGGQAGKGPRRKIPLAAIKARMSGAGPAGKKAAPPAAAAAAAAAAPVASTSQPDNKGKGKSKELKLSDSQLDAVAKKLAAEHPELPKLSPEQVQELVATMQIDKDVLSGKKGLMGKGTKDMASHKFWKTQPVVKLDQRDEVREGVLEADKKPEEVPKEPVALHKDFKWVTVNLSDANELREVYELLTHHYVEDLDATFRFDYSPEFIEWALKPPGYFADWHVGIRVAETGKLVGFIAGIPIELRVRNATKRCTEINFLVVHKKLRSKRFAPILIQEVTRRTHLRGIFQAIYTAGVFLPTPVSRCQYYHRNLNPPKLVKLGFSAVPRNSTVARMSTFYRVATETALPGLRELEKRDLKQASRLVRAYMARFDMAPLLSNKDIEHALWTGRGKDVNGKREGQVTWAYVVEDPTTHRITDVFSFYALPSTALKSQPISNVNAAYLYYYATTAAPSCADLGDGSVAVPVTNWKDETPGERKALGDRLKVLMADALVIAARNGFDVVNSLTIQDNSLFLEDLKFGKGDGFLHYYLYNYATKPIAGGIDADEGGSGIGVVMLCTSSHPRAVQPGTTGTGAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC72</accession>
    <name>A0A2S5BC72_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2569</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC72"/>
    <dbReference type="STRING" id="741276.A0A2S5BC72"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="429" mass="46410" checksum="A898CBBBF50BF6DE" modified="2018-07-18" version="1">MSFSFGFSIGADELDDELDIPTDSLRQLDIKGEHEHPEASSSTVPYAEVPLSELLGTLPPLLSYTPVVVPLSSSKGRTATLLRRDLFDARFQILNQDEDVDPDAPEESVDKEGTGTGKGKGKGKEVFVDEQSDLVKGVYEGGLKTWECSLDLVDCLDQRGFTLDAVDNTSFVRGTSVLEVGCGTAIPTCAVFARLLNEIARDPTPEDAPKPKKTRIHVQDYNKQVLQLITFPNLLLTYAQHFLLPAAAAATESKAPDADEEPTEPATDDSSTRPGELEVSPEFLDSFESFLARENIDLRFFEGDWAGMDKAIRAGGDDDELYDLVLTSETVYSVPSLGPLIDLLEAATTRADFSGGAGGGGTGSSCLVACKRIYFGVGGGELEFRRRVEERGAQVESVWGEGEGKGKNSGVGRTVLSVRWSKRSKKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC77</accession>
    <name>A0A2S5BC77_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC77"/>
    <dbReference type="STRING" id="741276.A0A2S5BC77"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="298" mass="31864" checksum="98B37F01AD7BF956" modified="2018-07-18" version="1">MTSASHAKVVLVTGSSAGGIGYALCEEFAARGCIVYASARRLASLETLSLGINRLELDVGSLESCTAAVQRIIKEQGRIDVLVNNAGAGGAGALLDADVETEEGGKATFEINFWAPLRMSKLVARHMIERRSGLIVNIGSIVGNIATPWSGIYSASKAALHSATETLRMEVAGFGLDVMLVAPGAITSQFGKKQSASIKLPADSFYRDVAERIAERSNMSQRADDRPLIGLLTDHTMPASKLAHGIVARALRSRPARYYSAGGKALLFWILERIPRPIVWFLLSRSLGADRVGKVKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCB0</accession>
    <name>A0A2S5BCB0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCB0"/>
    <dbReference type="STRING" id="741276.A0A2S5BCB0"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="219" mass="24279" checksum="922FB0668424136E" modified="2018-07-18" version="1">MIRVGEKLAGKGDVYASGSSAQRLFEVPFFPQPGEVFCYGYGLDYLSLIVERLSGLPLEQYFQMHIFRPLGITDMSFMSTPKQMLMAYEDPAAPHTPYAIRANDTLSETQHFGSAGLKGSPRSYLKIVRAILRGGELDGQRILKRETVDLMFKEQLTTDEQRQAFQRMAAINFDPSIRKANGNVDPATTHEHGGGLHAESPTGKALGTLSWSGLANTYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCH2</accession>
    <name>A0A2S5BCH2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_2474</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCH2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCH2"/>
    <dbReference type="OrthoDB" id="5310420at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="252"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="107"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY74475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="435" mass="47564" checksum="8DF4AA4510BB3353" modified="2018-07-18" version="1">MAGYDPYAGHYAHLPGTTPTYANAQRPADDDNIHQPYPATQVDQDPFATPSYHLNDNQEPTWPIQQQQGRYGQYGGGGGMYEGGGAHSTGDLADPNSYGTAAAQLHQPYHHQQQDGQGGMNPYLHPQHGVAPTTGGGGGGTYDDDAQAPLLQSSSQPHQYGYSNSTTGHAPGQADPTLNLPGGFDPLMGAQHHQQQQGGYYAGGGGPGYGAPYPPPSPGMYGQRGGGGGGGYDNDSIIRYGRIPQRQPRRYKTVKRVQLYHGNLVLDCQVPPKLLERCPRKDDREFTHMRYTAATCDPDDFLNEQYALRQILYQTPRRTELFIVLTMYNEDEVLFCRTMHGVMKNIQHLCERNRSKIWGADGWKKVVVCVVSDGRAKINARTLSVLAAMGVYQDGVAKNVVAGKPVTAHIYEYTTQSPFTSPIEYGDTAQHGDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCK1</accession>
    <name>A0A2S5BCK1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCK1"/>
    <dbReference type="OrthoDB" id="2529972at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="126" mass="13200" checksum="BE5F356ED4D548BE" modified="2018-07-18" version="1">MLSRSSSISSSCQGLRRCSSSGIRSLASTSSPRVAKVASPATPSAPSRMPGTRSDTRQADAQEPPADGSSSPNKPKLRSPTDPAADYQRRLEERFGGGEAAALGQLVDGKPEGLAANVKRNMFRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCL2</accession>
    <name>A0A2S5BCL2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCL2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCL2"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="538"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="827" mass="88468" checksum="90D6B710BB3C95A1" modified="2018-07-18" version="1">MPLWGRATPSSPTRGGSGDSQSDRSHAASSSTASTSSAPHSLGYGRAPSAPQGTGRAPPHRSMSTSSQKHVSLNAATSSSSSSSDPRSSGNRRGSTPTAVPVDDDGTWNEASDDDDLPADALGGLSLRDDRTSRRGGAQSTTAAAAAARKSISPIRTGEPYSASGQSPTSAGSTWSFNPFSLRPAARPSHASTSSSLFGTGSSTTNATSGSSPASYFPATGGGTSPAATPSVLYSYSRATPAAAATAAGSSRSHLPDSVSTTSLPVASPGLSSAGAGSVPSPSLGAEAVAAALSGRPGGLHTSLQRGTSYLAGASRVQEEADRVVQEEVEEERRRSSIERGQAPRPLREEVETDGEGHDRPAQETEGGEGHGKEKCKRAVRRDVADLVKDPAHVLARLRTAWQPRPAPSRTSPAPPSTAAAPDPSDFSNPGSPELPSHPPPPPNGYRKRPTAITGGSGKDADSDSDSGPPLGYAPLNANAFSSHEANLIATELEPAPPNPEEEGERGRENRRKRKFLEVLGDEENVDLAELRKLAWSGVPNELRPMVWQLLLGYLPGPIARRTATLARKRTEYASLVKQAFSRGVKGLDGPLWHQISIDVPRTRPGVPLWQAEATQRSLERVLYVWAIRHPASGYVQGINDLVTPFFQVFLASYIDADPETFDVSVLPPEVLEALEADSFWCLSKLLDGIQDNYIFAQPGIQRLVKKMEVLCGRVDAPLAAHLKEQGVEFIQFAFRWMNCLLMRELSVKNIVRMWDTYLAEGGDAFSEFHLYVCLAFLVRWSEQLREMDFQSIIMFLQSLPTQEWSDKDTELLLSEAFMWSRTFVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCS5</accession>
    <name>A0A2S5BCS5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3">2.1.1.354</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_2335</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCS5"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6 18" id="KW-0489">Methyltransferase</keyword>
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    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
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            <begin position="1372"/>
            <end position="1489"/>
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            <begin position="1496"/>
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            <begin position="1269"/>
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            <begin position="1"/>
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            <dbReference type="ARBA" id="ARBA00047571"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
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            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50868"/>
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    </evidence>
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            <dbReference type="EMBL" id="POY74574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1512" mass="163934" checksum="CBBD02F311F2C4E7" modified="2018-07-18" version="1">MARDGDDRDSTGRGHANRDSRDSRRRDSSPRSRDSLSPHLSRSARAHDEPRRRYSESRPESPPRDAHRDRYSDRDRPGPSRHSRYNDDDHYYDRHRTRSPSPRRRRSPSRSPPRRRDSSRRSTSPPPPSSARSSHPNGSSSRYHDDKYSNGRDSHRSPERRDRRDLPATSSRDRDPPASSGSSSRMTDSARGKEAAATTSSRPSRQSISIAFPNAQGSSSASSAKPLAAFSGSSTAPSADPRTASAPAPAPTPSSSTTAAAAPPRSRAPASSSKSRQAAADKLPPFFYKPLKSKDYRVVYDPALDTNPIKKGKAVEHRYDGEGLPEDAGKKDPRGPKGEFDQVLQKAKKHLLAKRVGVITYNWDKNSKGPAPPLPPCAILITGFPPSTSGDAIYTHFRSFGRIEQLDLKIDPQTGGNLGICWIKYRDDIPRDFEPDRPTREKYEAKRRAGQAQDGAAVTTTAVAQGNGAKIGLTMLRAETGVKVVLDADGKLCKEAVDAEMLRLHPPPPSAKPKVESSSKTPDVRARSASSTPRLPASSLPPPPPAGAPPPPPSLPPPPPPPSSSRSGTTAAGSSRQYSGRDSPVAGQSDRWAPTPSGPRTSSSSRPTLVLPSRPAYISTPGSSVPGPQSSSAASRPPVPLPSGSTRSRGETPPELRLAKPRMAIPPLPSNRLPARPDRRPNVPAPAPQYSLPKLGGRAPAVPGRGVPGRSDDMASAIQQAVQAAKKRLQMRQSQEQNGSKSGSRDKGDDRGDVDMEMSSDDEANKSGSDNSSAEESGDEGDARDRLRYANSSGQSHVRRILPRGMAPAGAIAWQVSKKILLEKLRANGRPYLVIEKATFQQDRTDRHGTKAAPSNEELQHLFRKYGIDRTFADADGWYITFDARDSARRARDAVDGRRFAGAPLRLQLEEKAAELPVAPKPPVLPPKPSPRGKAPEPGSALEAIVKKLAHPPSKPKTRKTSGWTESELLDEAKDIVIADLLDAFESDIISRLVRGKVQEHLVRWEGDGMQTTQAPRRDEGPQPHGDQPEPADGSSKSLSSLSFAKRRSADVARVSQAKRKPPPTVRMPSETPSETPSGGHDASDRGSPALTSRAVSKEPTSRAAPPPAFASSDEEEDRPRSRPSERPKKAVPKRKKASKKVRVHLDYTSSEDEADPADVKPKLIAIKEEPADVVDVRSATHLPSIFTTEGRNDMDIDGQPHASRSPSLQAEPIERKPSKRPGAAAKKAAPRPMPPTATTDPFEAGVAEDEEDLFFLKLAIERLHLGKELNPTPPASDDEDNPPKHTSGSARTEGFYAITVEEKMANRPASNRAKASRNGAVANAAAASSVAVSRLARANTRGLVRGMELHKKVTATDTDVLKFNQLKTRKKQLTFARSGIEGYGLFALEHIPVGDMVIEYVGELIRQTVADRREKAYERSGIGSSYLFRVDEDLVVDATKKGNLGRLINHCCAPNCTARIITINGVKKIVIYAKSNIEPGEEVTYDYHFPIEEDNKIPCLCGAEACKTWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD50</accession>
    <name>A0A2S5BD50_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD50"/>
    <dbReference type="STRING" id="741276.A0A2S5BD50"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="299" mass="32651" checksum="0F3B33471F271BAD" modified="2018-07-18" version="1">MSAPEQVAQNYSFDGTITKYKGTAAALGGLETQFNVFLPKQALDGDKVPVLYYLAGLTCNEDTAPWKGGFLRDAAAEGIALVFPDTSPRGASIEDEDKDWDFGTGAGFYINATKEPWKKHYNMYDFVTAELPQLLEKLSLPLDLSRSSIFGHSMGGHGALTLYLKSVLASSPSTKYLSASAFAPIANPTQCPWGDKAFKGYLEGGLEEGKEYDATELIKQAKGKDLKVLVDVGTGDNFYKQKQLLPENFIAARDAAGFTEKDVSVNLHDNYDHSYYFISTFAPAHIKFHAQVLKGASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE32</accession>
    <name>A0A2S5BE32_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="7">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2006</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE32"/>
    <dbReference type="STRING" id="741276.A0A2S5BE32"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="10">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="499" mass="52996" checksum="488694033BC89054" modified="2018-07-18" version="1">MFKQLWLVEPGATIEEFDPLVEVMSDKASVEITSPFSGTVTSLAGKTGDMLKVGSTLCSIEVDGGEAEDTQEDLAAAVDLSKATKEAPESRTVKQSEQAHSPTVSPSLEPPLERHTPSPKASAQPAKEVLATPGTRRFAMEKGVDISTVTGTGRHGRVQKEDILAAAAAASTGGESSVTSSAPSASRAPSSGATSSTPPPSTQNLPLSPIRRAMFRAMSASLQIPHFAYSETIDVTSLERMRLALSSDIPLRYRKTIKPADEATLARLAPWQDGSAQVEQSKRFDRLTMLPFLLKGLSIAMHEHPLFTCSLSPAPSASNAATEDPSLVRRSSHDISVALSNPSPSGGLFTPVLRSVDSSSIFDLASRLAHLQSFLDPTSSSAPKFPSEYSGAGTLTLSNIGVVGGKSTHPVVPPTGQLAIGAMGRMRVEPRFVDEKAAKKVAQGIDGEELSLDALRVEPRLVMDVTFSADHRVVEGVELARLVETWKRIIEQPSRLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEF2</accession>
    <name>A0A2S5BEF2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEF2"/>
    <dbReference type="STRING" id="741276.A0A2S5BEF2"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="33735" checksum="E10D696B3D12B0BF" modified="2018-07-18" version="1">MPSSTDARNANVGLNLAGKTAAVAGGTQGIGAAVGLRFAQAGANVYIIGRNEQLGREVVEKCREQAHDAGDGRTYEFIKADLSSVSEVRRVAEVLKEKSGSKGIDYLVTSQGGPPNGKYIQTSSTPAHDAHFAVQTLSRFGLAYLLASSGILKDTWVSVCAPAGEKGPEPDVDNLELEGAHRDKWMLGRVMGQAKQDSALGDAIAVQFNQHFPSLRAVHLFPGFVYTNALASASIVPRPVLWAYGYVGPLMARFTPMGNLPAWYAEIPVYIGANPSARGKGLEASNERLKPLGWPAWAEGTTGKKVWEKLKAMVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEF3</accession>
    <name>A0A2S5BEF3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BMF94_1753</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEF3"/>
    <dbReference type="STRING" id="741276.A0A2S5BEF3"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="18">
        <location>
            <begin position="897"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1052"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="POY75123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1075" mass="117643" checksum="F810605ED5E7AD2D" modified="2018-07-18" version="1">MVGIAYIEKMLDLDKEAGRYFIRTCGEESHLAYNRVGLTEYFQHRNVSDLYLQSPEWYSQQLPDRFAYSTGEKVIEIDPVHKNVHTSKGNTYQYDILVLATGSNGALPPYISPETAAETKGVFVYRNVADLEAIMDYADKPEINRASVVGGGLLGLEAAKAVYDLPTIPTVNILIRQQYPLNRQLDAAAGELVLNKIEDMGVEVLTGCEPQAITAKDGVFTGFEFADGSKMETDMVIYGIGISPRDELARNAGIKVSPRGGIQVDDLLRTSAPDVYAIGECASWRDNVFGLIGPGIEMASLLAFNLTQTAGHAPRQMNAPDLSTKLKLMGVDVASFGDYFADERMQKEAESAHLEAQKATTADGVAISTPGPSRKRPRSTRTDPIKCLTYRDPIAATYRKYIFTADGSHLLGGIMIGDTAAFTKLVAIVKKKKKLDVPPSEFILGAKKSEDEDGADLDDDTVVCSCHATTKGAIAACVKEGITDFAAIKCKTKAGTGCGGCVPLVTNIYKAEMKKAGNAVTNHLCVHLKMSRADLFQIVKVKRLRDYRSVMQAASSTPDAIGCEVCKPAIASVLASLYNEHVMKPRHHGLQDTNDRFLANIQRNGTFSVVPRIPGGEVTPDGLIVIGQVAKKYGLYTKITGGQRVDLFGVQKADLPAVWEELIAGGFESGHAYGKSLRTVKSCVGSTWCRYGVGDSVGMAIDLENRYRGVRSPHKFKGGVSGCVRECAEAQSKDFGLIATDKGWNLFIGGNGGANPLHATLFAKDVPPTKVVRLVDRFLMFYIRTADRLQRTAPWVESFEGGVDKLRKILIDDELGICADLEAEMDNLIGTYQDEWAAALRDPTLRQSFKQFANTSERRLNSELITERGQQRPADWPKEFPGQRFLEQDLPTPRSQWQYVKLATVDDLSSTQENTTSCAVRYGEDTQLAIFHVPGKGYFCTQQMCPHKRAFILEHGIIGDDANGHLYVSCPLHKRNFRLDNGDCLNDDEYKILAFDVKEQDGDLLVQVPPPDELDTLIGSSKWMVKKATADALGRNAATAIEIVGPTGEVDEDKKAAGTECGEADKSCGSHKLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEQ6</accession>
    <name>A0A2S5BEQ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEQ6"/>
    <dbReference type="OrthoDB" id="3346152at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02228">
        <property type="entry name" value="cupin_EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06249">
        <property type="entry name" value="EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14094" checksum="3826C79EFF3F5807" modified="2018-07-18" version="1">MSIGESKHSNPSDTLAVSKNAMQVHELTTPLGKIGWIDDVFTTHWDGDKPISAGFFTVSAGEPLDYTYGYNELKLVTEGTVVLEDKTKGTKIVAHPGDVLSIPKGTPVTFSTPNFGKAFYVGQRAYRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF86</accession>
    <name>A0A2S5BF86_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF86"/>
    <dbReference type="STRING" id="741276.A0A2S5BF86"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="1048"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1143" mass="128683" checksum="F253BE4588165AAF" modified="2018-07-18" version="1">MAEPTPLSDAEKIRLKRIAKLQQQQQKQQDEQAAAGPSASSAPTPPTAPKPAPLPVAKPPVRNVAGAVRQTTQADCGAFSNLSVQAPRPAPPPAQKPLTPQPRQPAKFADSYDQWQSRVVADILNVTLDVDAARGSNWSIVYLKDVANELDEEEPPTSRPRPLRIDLADRLLLARLSLSPSNMNDDDFEQATVLASLPENQTAFEYLGSCWRRERAERFKVVAKKDSDADEAQKRLAGLSQIKALLVSYIGLVLQDSTMFPQEHVTGKPLGALELEPLLIPNSTPIPPAYLQLGDLPALLTDLANRFTPSAANDFEGGLEDILLPLFTRWNTHLLTHKLDIGGGPANVLGGGASASPSWRDILQAVQSLTEIKLIAATLPTLQGWDLPAGQAQAPRLEYATLLGPLLRLSVFPDGAPALPQAYFPDPSVMVRGNIDSASASLRGTLNGVQQSLFRIFDNIVRASPTARQAVLAYLGQVATLNAKRAAMRVDPNTVSTEGFIVNLHAILLRFAEPFLDAGFTKIDKIDPLYYRRSSRIDIKEDTKINATQQESDTYYSGATHEEEAPAPNFISEIFFLCAQFLHIGPMHATKEHKGIGQQISHMQRQLNDMEADSTWRGTPQEAQMQTGIDRYKKKIDQWRSQHLAYEVQLLDPEYLAKCSSFSNLVMAWLVRLVDPKKQHPHVRIDLPLLNEVPETFRMLPEFLIEDITEFLSFTSKYAPQVLESSSQEELMSFMLVFLSTPYMKNPYLKGQFVEIMYYLSRPTYTSRQGCLGDVLNFHTLSLRYLMPCLIHAYIEIEITGSHTQFYDKFNIRYYITQLFKLVWSNPTHREALKRESQVNFDRYVRFVNLLMNDTTYLLDDALVHLGKIADMQRAMDDKTTWEALPATERQEKEKLFRQYESTVKSDLDLGHESLRLLKLFSHETKEPFLAPEIVDRLAAMLDQNLHVLAGPRCQELKVKEPEKYRFRPKELLSDVLQIFLQLGPNTPFQTAMAKDGRSYSRDLFQRATRIARKTAIKTDEELSEIAAMVERVEVIKAAEEADDALGEIPDEYLDPLTYDIMRDPVLLPSSKTILDRSTIKQHYLSDATDPFNRQPLKWEDIVDAVEMREEIQRFLTERKAKRAEAAVAAVEAAGDEPMRLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFI9</accession>
    <name>A0A2S5BFI9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1415</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFI9"/>
    <dbReference type="STRING" id="741276.A0A2S5BFI9"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="28"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="415"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="494" mass="51674" checksum="F80B77FC779630ED" modified="2018-07-18" version="1">MGQTLSEPVVDKHSQSGKDARATAPSSDTSEREKAGRRIESPMEDAHSAILSLGDELEGKPTSFFAVYDGHGGSTVAKFAGDTVHSRLANNAHFKKRDWEASLKRAYLETDEDLRANPDFKGDPSGCTAVSTIITPEMNIICANAGDSRAVMSVGGEAKPLSFDHKPTNQGETSRIVAAGGFVEFGRVNGNLALSRALGDFDFKQSTTLDPEQQIVTADPDITVHEATSEDEFVVIACDGIWDVLTSQQVIDFVRLAVSEGKSLQTICEEMLDRCLAPDSDWGGVGCDNMTMMVVALLGDRSEEGWYSWVKERVENSEGYPTPKEYVEPFGQGGNGPRGALMAGGSGANNAAANSAPSGILGGALRVGSLADGTVQLSFGGDGANGVTGEDDSEDDTELDLPTIQAALRARMAELEQEEALGSGAAGNAANDDDDEDEAMIEDADAGAAGVTTGSTGAPAAVEGGENAASTDAAAEELDPHKLRTSHSPPEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFL1</accession>
    <name>A0A2S5BFL1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFL1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFL1"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="591" mass="67340" checksum="98DEE96193DEAF2E" modified="2018-07-18" version="1">MSEDVGARPAWWKEGVVVYQVYPASFKDSNGDGIGDLPGLISKLPYLRSLGVEAIWLGPHYASPRKDEGYDISDYKSVYEPFGTLDDCQVLIDEAHSHGLKILFDLVVNHCSDQHEWFQESRKDKANPKRDWFHWKPPKMDENGGMSPRVPPNNWRAEFGGSAWAWDDATDEYYLHTFDVSQPDLKWENPAVRQAIYHDAVRFWLDRGLDGFRIDTANRYSKYTDFPDAPVTEPDMLWQPAGQLMTNGPRSHEYIQEMRKEAFDAYDCFTIGELPSTPVLENILSYISSEAKALSCTILFDLMELDHTDGRYPLMALPWKLSDFKRLTAFGQQLAEPQYAAHALSYLENHDQARSVSRFASDALEHRTVSAKLLATYLLTLSGSIIIYQGQEIGMINAGKDWDIEAEYKDLCTINTWREIKEDAEKNSDPSLLERGREGIQLTARDHSRTPMQWDSSHNAGFSTKEDAKPWTRVMESNKEGINVAAQEDDPESTLNFYRRMLALRKEHKDVFVLGKFDLHDKENEQTMIYTKTSQDGSRVALVALNFTSEPQAFDVPSSLKDKSTGKLLFSTVGGNSEGELEAYEARVILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG08</accession>
    <name>A0A2S5BG08_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="582"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1168"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1275"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1293"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1315"/>
            <end position="1329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1329" mass="140625" checksum="C2EB014C80CC117A" modified="2018-07-18" version="1">MEDEPHETIDVEAPTAVTNDTVDGDALTTSSTGVVTASKSSDDSNEANRDKARGSGGGDDGEAASRDSAPYVGPSGGAPATTTTTSQDGPQELDRSEAPTMTTPGDLPRPRPRRRLPPAPPKGILRPPSSSHAATSRFSFRRDILQPFNSSYSRATTTAAATTAGDGPGQAPGTTSERGAAAAAAVGEAVGTAATVAGGFFGNALKRLSAAAVATTTAAATPTQSGSAAAGGGGGAPLALGALMPGPPTGAADRSSTGIAATNGESGPLTAPPGHSQSAAASVSTLSLTPSAAPSTASTAVPSSSGASIASSTQIAAPIQPPQPPLPVSSLKLVRFRMASIKIVYPINNGTLDPIAPSDEGETRDRIEREWRNEKGLAVVSEEEGLGRVGEKGDENEKGVVVRAVGEEKRRARSYTGEELARIYNESCRTREEPGIERVKRFFRVRRLSVRAERTRGETARADLLPVKQENPKSLPKVLDLSHELLSFGAVAALSDVLAIDWGCRKLVLEGCGLDDESVKPLLHALLVSACVPTISLAGNKRIRNKGWKLLAVFLRKATFLRYLDLSETSIDKKAAEWLVQAVAPPPPPPPPTAATIADTSTDPESKQPSPRPRVKGPWEDEDDSADEADNAPDPAPFAPPESAKDADEARQDLAAPRAPLFPTAPLLKEDWEGEMAAVQSLRFENCGMRGPTLEVLANGLRLSGVKHVSLRKNRINHAGGPALAIMMRDYPLSTDASAAALNASLNSPSLTSPTIFRNGFSHGTSDVSSSPEPAVSEGRNSVTAHRRHLFKPLEQHLPHLPRPNSPSAGHLLSEDSGRNSPVPSDREVNRMTEARTKLRKQLDGLPRFGALLTLDVKGNDLRHGVTYVAQVLKRNRTLKTLNLSENRIDSQGLTAIAEALKYNSTLETLDLSHNPCCGPGVDGILALRSTLMVSHSLKRIFLNSTELTSEGAIALAEFLPESRSVLHLDLTNNNIDISGVLALSVSIKLNSTIRCLDLNIPPNDADFSRLSQDILNTCVRNTEIAQEKADSEARHAADGAKRVLVAQPIRKSALATELEEQQRAQEQRQRRRQDVLRSQQDILAAAAETRDVVRELLAVDEAAAAQGSNVRPSEVTRDALVQLQLAEAQLAEAAPSSGTGAERERVDLLLSELSSLLDLAKSLYDGPAASTKARRRPIDAGTPFPKPDRPAPPSPTLSAASSPDEEAAVEEDATGGDQQKRKPDSLDLPTQPSMLDPARAETPPVRSPIQSESRAMVEEESEVFRRGVALGVDEVSDSEDEDDTSDKVAAARSEDGSPKKKSEVSGEELRKEASLASSSATTSRMRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG13</accession>
    <name>A0A2S5BG13_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG13"/>
    <dbReference type="STRING" id="741276.A0A2S5BG13"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="640" mass="70160" checksum="A8176356107285D3" modified="2018-07-18" version="1">MPRDEPTASTSRARTVLTPSCETCRLRKIRCQRPEGFQLDMTVPCQGCVRKGIQCVFVDRPRTRNRSGKNVEAARERYGALTSSSGSGSSHQSGSVTPPLLPPQDALVRVELAGAVGFRLLESWLDQAQERTSVPNMDPPVIDFWALLERYYAVGQKLEHLTPIDQLQCRIVYATAAPIHLPDRIAGDTRRTVARQLRQDAESMADSLAIWRKPDPRHVAPLMLLYKPFSTEDNKNDDAVPYLAAAISHCRVLAGRERSQPTVTAGGATVNVSWTLIIMDVLSSMERGRKPHLSRDEVTDFLGEDRASLPILEDLRLTVGSNAEAAMALVMQAVSTLMLIAFDVAAVSAAPDCHIQAFHALWARLDSVYEWCRKTNDVDASPDHGGGRLFWLYGSLLWATSITIELSLVEIITALIATAAHPSSRSSGWPNTGRLSELVALSALAQRRVALRLCAYLPHTYGSVDRDPLYTLAIMPGATCSVARVLDIAQTLARTSCDDAELFPLGAHDRLAALDHVLVQVRRLAVGYPGPKMDATVSILEEEQRKMQVTLAVTTSDDNPSTGDHTSPTYARASSFSQSSSHTPTGALNPLSLDNFPYDTFLPPQVAHDAQDLLFPSTVESPFPFLSSAQVTDVWDWQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG50</accession>
    <name>A0A2S5BG50_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG50"/>
    <dbReference type="STRING" id="741276.A0A2S5BG50"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="294" mass="32141" checksum="1D733A6BC36C7E0B" modified="2018-07-18" version="1">MSSLNMRDNHQRAPPELKRVVDWLRNKSGIKTKQGALAGKRVEYFKGKSAIKALRSPAYQKLKNVPALDPNAGDDEPARQLLHSLIPHTFFLRIQRGPSISSGVKAVQIVPQQLFAPEEYYVWLVDPNPIRQLALAIGMVAVVLAGVMFPLWPIKMRVGVWYLSVGVLGLVAAFFGLAIVRLVVWLITIVVARPGIWIFPNLFADVGFVDSFIPLWGWDVPPPKKSKKSSKHGTGDGHEKRSKSKKSSGGGGISAAAAASAEEQAQMIDEATEGPDTTPLSGARIEEIFESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGL6</accession>
    <name>A0A2S5BGL6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGL6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="173" mass="18954" checksum="C3A5C89A26982A02" modified="2018-07-18" version="1">MCTPYDAINNAHNDHQKSWRQRVQERDLTPYERNVRLSSVKGAHIFGASFSSITSATTTNTIATEAAIKELAQEEDLLANWLRRSLSSEDVKPDIAQATTVESPATSYRECLKTIDEFERQRKLRSTTSCAHVRNAVGDPAHSQGTIVPLAPLASPPATSSQDVANSAAPMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGQ3</accession>
    <name>A0A2S5BGQ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGQ3"/>
    <dbReference type="STRING" id="741276.A0A2S5BGQ3"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="75766" checksum="AD763979E758FE15" modified="2018-07-18" version="1">MATPAPNSFGDAHLQQPPTHYFETEENLVISIDIGNTASSVTLAHLSWGKAPLSSSSTSAPCIRSVLTYPHSSPHLGLGTSARVPSLIAYDRDNEPRAVGNECLTGEVKQRIQDGSWMLVKGWKEQMRPRPPTESRRSEAEPANGTSSTEKVHSGAARKLLTKVKKAPRTVEEPALNAIRPIPSRQSLATSGAASGFSTSSEQLLDAVDPLADDAPQPELSVSPQRFATIDGGTGALGDFAAQKPAPASKKEDGSRTAGSGPRLRDIYAAFLRYLVACARAWYAEAVQGGEAIFLRLWKSCVFILAIPMDWTAGETDLLRQAVEDAKLLPPDFEVGRLFFVKEPVALLQFAREHDGSTFIVVEVTGTGITVAGYETLSSTPRLRYKPHGIVRLRNGSEEVVARFRQLVVRRLARSKVKSDLVVAHLVAEFREKLLLSFTGAGSGPGPETFNLRIQGRGDGSKDWMRLEQAIDTGARVRDGVMSFDAQDIEDVYRPAADDLLGFGNSPCLRNRLAGLGTVNLLFPAASPHLAVSEGALRLYLIAALKHGRLRKAIGVETAVDWSKSWMPGMQNREVTLASDGQRLVRGKFTAIAQEGEIIDQSKCWLKPFHLKYRLAAKDPSFAATLFAREPLPATARPYAHFKRLGTVRANLADLVAEQPVQEADNPEQAWVQLDLALSINVTSRGLSAFVAWQTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGU4</accession>
    <name>A0A2S5BGU4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGU4"/>
    <dbReference type="STRING" id="741276.A0A2S5BGU4"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="181" mass="19463" checksum="92D561BAA0F68E25" modified="2018-07-18" version="1">MSIVELKGENSFTALAVATALVLRIRRRLYTHTQHVWPSSEATRPDFEDFFGRIGKVIDIRIMAGFAFLEYEDLRAVNECNNRDFLGQRIMVEFAKPPRSEFGPPPPRGGGFGGGYGGGYGGGYGGGGGYGGGYGAPPPRGYDRPPPPRAGTGHRIQIAGIKEGTSWQPLRNVVVVHVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH97</accession>
    <name>A0A2S5BH97_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH97"/>
    <dbReference type="STRING" id="741276.A0A2S5BH97"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="472" mass="49253" checksum="CCB19E3A54A199FC" modified="2018-07-18" version="1">MAKYDTIIIGAGMSGLAAARQLPHARIAILEARTRLGGRILTANGNLGLKEPVDLGGSMVHGYREGNPVAALITRELGMEVHIPEGAKGLVYGPEGPLAEADATSLFATSAQNAFTPQPGTSASTSVADHLLPKLQHDPKLVALARTAEIGAGVPLEEQSAKFGGFEKGFKGTDGFPVGGYGEVVANLASDVKASGGEIHFGAVVAAIEDDSTAGVVTVTTEAGQAFTAKSVISTIPHAVLQARPPRFSPPLPASFTSAVERMRTGALEKIVLSYSSAWWPAPKENGSFLLLPLEQTGSSSASLDELFASTTIPVTSFERIGLTPHPTLLAYVGATAARTMSKFSADDITAAFHAYLVKRLAPPGTVPSPTAQIVTTWLSDPFSLGATSAPITITSSADGDESTPLDYILVSRPAWQGRLGFAGEHTDLDNHGSVAGAFISGRREGQRVKELLERLAADEVLEEAAREKARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHK4</accession>
    <name>A0A2S5BHK4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHK4"/>
    <dbReference type="STRING" id="741276.A0A2S5BHK4"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="797"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="854"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="492"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="896" mass="93657" checksum="611D1864D00C1E18" modified="2018-07-18" version="1">MAGIPSSRPGATSSSRNSPAPSPSLAATLANASPSSSSLPIPQIPPHNATATATTHNNSSSNVTGSPTASAARTPAYFGSPRAASPFPPNAFLAQDAAGADSPSASGIPLTDAQKAEVIRRHLLNADEQQRVALDQAASSSSPRNQAGSAFPQQQAELAAVAAAAAGDAATTEEGGDENQYPTPYHLEGGDVVAGVYKWVAQQAGDSAISGLGVGTSGATPAATGGIASSLRRSRSVASLPPNAGGGGSRRTSLAANNGGGDAGRAAAKLALLAGEDVQAADDDSSAIAAVDDDGLTTSEMLQPGGFRRDFVFRRQHQQQQANASGLVVDSHPGSDRASLVSQPGESGYVNVTGSGAATPNRPIYGRPTRSFIDFLTLYGHFGGEDLEEIEEEEDEEEEEEDEEATIGDRELGGDQQGRFADLVDGSRKPGDGTAGPVAALRANERTPLIRNRSSVRSNRSMSRRRGGGAPGAGGQGGDDGEPSGMKDHGDATVTQAVMMLLKSFVGTGVLFLGKAFYNGGILFSIITLCFIAMVSLYSFLLLVQCSLVIPGSFGDIGGRLYGKYMRLAILFSIVLSQIGFVAAYTVFISQNLQAFFLAVSNCRTYISIALLITAQTVVFLPFALIRNIQKLSGTALVADVFIVVGLIYIFSNEIALLSKRGVADVKLFNSKDFPLLIGTAVFAFEGIGLILPVAESMREPQKFPRVLTGVMIGTMCLFAGGGALGYLTYGSKIQTVVFVNLPQDDKFVNASQFLYSIAILLSTPLQLFPAVRIMENGIFAPQKSGKRSLKVKWEKNAFRTFVVVVCALIAWFGAADLDKFVSLIGSLACVPLGLIYPALLHLKACARTRKQKAADIILIAFGAIATVYTTVQTIQLLTSPSDGPAEPKPHCPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI96</accession>
    <name>A0A2S5BI96_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI96"/>
    <dbReference type="STRING" id="741276.A0A2S5BI96"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="416" mass="45180" checksum="51D4EF4E7028DFF8" modified="2018-07-18" version="1">MLRSGITSRTARRLVEPRATVMPVLASPYRSFSSGADDNLAPPPTATTKPSLLELTAPTSLPDPTLFEPLSAAFLSLPPTVGLSYAAFVPLFTVLYRSCTTLPIAFWQQARIRRFRDVATPVLKRELGRVALETRADCRRAGKSFEEYQAEYKKRAKRMTHDVARKFNCSPRLTLFLPPLFHIPLLVTFSLVLRDACARAESVLAVAPSNLASLLDASPASTLTSTALAHLHELASTPLWWCPSMILPDPTMLLPLGVGLSALLNVEVNQRTRRVATDAAATEDPVAAPLGSSSSSGAPVAPAAPVTPSIAERRRLAARRAHGSRGLATAASGAAADKVEIVARKPDSQRIVTNVLRFASVAFIPVAGLAPSAVALYWLTSNLFTLTQNLTFWWRDRTREKERRMRDILSGRAVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIY5</accession>
    <name>A0A2S5BIY5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIY5"/>
    <dbReference type="STRING" id="741276.A0A2S5BIY5"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="371"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="447" mass="45292" checksum="E97D4B6F5AB578C8" modified="2018-07-18" version="1">MEAGIRQTHVYLLAFLKTQQLSAAAKALVKELNKRPYEGEGVDKLTGDAAEAEAAKCTGLEVVTLVRAKIEMAKEMSAKESSQAGVVEVDSSSSDSSSSSSSSSSEDSSDEEVEKEVLPSDKLAAVQAERATDASSSSSSSDSSSDSDSSSSDDEGDKEVKARNPAKAPSPARSMAPPPMTPAPSSIGSKKRKAPSSSSSSSSSSSSSSSSDSSSSSSSSDSDSSSSSSSSSSSSSSSSSSSSSSSSSSSASSSKKSKRPAAKKQRVASPSPKSKSASTSASSSSSASSDTIASPVDGAAAPTQSVAAAGATETASTPNAAAAATPVPRAHFMHPSRTATPLSGNESGSGTPGGGAKGKGKQQQQQGMNERFRRVKAEDVVFVDERLKDNSFAARPAGMSDYGAKASADLIVTRGKGFTKEKNKKKRGSYRGGEITMASHSIKFNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZR5</accession>
    <name>A0A2S5AZR5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_7110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000177">
        <property type="protein sequence ID" value="POY69891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZR5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY69891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="35" mass="4332" checksum="2109747729DB8193" modified="2018-07-18" version="1">MVRSEPTSEFTSCRRVTASDLWRRWQRHARRLPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B045</accession>
    <name>A0A2S5B045_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative Procollagen-proline dioxygenase</fullName>
            <ecNumber evidence="15">1.14.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_6737</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="15"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B045"/>
    <dbReference type="STRING" id="741276.A0A2S5B045"/>
    <dbReference type="OrthoDB" id="2212237at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="14">
        <location>
            <begin position="203"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="456"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY70154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="686" mass="75827" checksum="EA9BB116EC1AC196" modified="2018-07-18" version="1">MELYAVPGSDKHDLASLDPDSLVAASYLQLLCPQQWTLVHSADDALPQLKHHGQHIHSTAILHHLESTSASSEPTAAHPDAKAFHALLDSTLLPLVLHSLYSLPQNWAFVRSLLAPALPFPTAFYRPNALRAHAQHTVEATHPEWWGLGGEADREAEEERKRKKALLETGIEGIKERKDGERRDGKERMKKTFGEGKIVSAARQVFTALESTLAASSTPYFFSSSSPTPLDAHLSALLSLVLYLPLPTPILADLINASFPRLWAHSALLRRTLWSPDSVPLPKVAGGSASKATASGGVFGGFVATLREVVLPAPVRAYFTPSIQPRQGASTDSRTSTSSSKPAALSKKDRDFARKRYAFFAVCAVGLVGWGFGTGAFPVPPLARKDAAISAAWPKLFQMAQAHSWANLNYAVEKSDINEHYGNGMAAMGLRMFTEQPGLGWWRPVEETTTTDMAPCAVCSATAAQLCSRCRGASASGLKQAISLERMADSKRKAPTEVAYCSTEHQRSDWSRHKLACKAAPYKGTKRPRELAERGAPVMSLLTQPTTEAELHRSLIPFPKDLPRETKYERLIDAFRLHQDDQFYWNQKREGLYKTPQEDPYPLFVKFVKRARPHLPTWWSDDDTTRVLAMSRTHPWARLDTPVEKAEVNERYQNPSTALGLRMWTERVTGVRFGGSTSPLPPIPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B057</accession>
    <name>A0A2S5B057_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B057"/>
    <dbReference type="STRING" id="741276.A0A2S5B057"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="613" mass="63952" checksum="F16C75BDCF19D33B" modified="2018-07-18" version="1">MSGSIHDLIDEALAHAQAVWESVVPADLSNLHDLGGKVANSLDDLLEKITNNGTLPVPNPRDWLPEQLQPAPSPSAAPAPLAAHSSASAWLHRFAQHTARHPYAYATAAIGLTGGASYYWAPHATLRVLEPFTSWVPVALLPDPADRPLRLTPAQHGVAGEVRKEAVVVLGADSPHGRELALDLERRGFVVIATVADPANVDALERSSRGWLKVLVLDPHESSSVSPFLRSLSTALSLRYPLHSSGDPFSRPAHALALTGVVNCLSLAPTTAGADAPYPLEATESDAVRRQVGERVATVVGALKGLLPILRSAASRPGAPTGVLISLVPSANSNLSLPFASLASAADAAISSVLHSLRREVAASTSTNVRLTALEVGFFQTTPVPTTMAAQRASNYFAPLPIRLESVYAPALARRSPLDMTNTSEAASPAGKSARKGTEMRKLCKRVWQILARPAHAGAVARVGSGAWTYLFVSYLPHAVIDVCLGVQDRLYGIYFNHVRELVTSRRGRAIDSAQPGPSTRGPLPTPPASRGGPFRPGPAQVPLADPFMPTPSPAPSSSRGGGGAGGGGYSSCDEASSQSSTEDFGPLGGSGYVSGSASMGGSFVSVGRDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B072</accession>
    <name>A0A2S5B072_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000151">
        <property type="protein sequence ID" value="POY70061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B072"/>
    <dbReference type="STRING" id="741276.A0A2S5B072"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25986" checksum="95433C9983E27B04" modified="2018-07-18" version="1">MGGPAAAPNANDGHLRITYDEIHVTIGQTAQRIKEQFDPDIMVAIGGGGFFPARVLRTFLKRVSTADGKRRNIPIQAIGLSLYEEVGEADGANGLAMEEKLGKEVIRTQWLDFSTLGNRPLIGRRILIVDEVDDSRTTLGYAVTELKKDIQAQFDKLSAEKKAELPETKLAIFVVHNKLKEKRAEIPEDVSYFSGADIPDVWVDYPWEQEDILLHNAVASQQRAMGQTLEAAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B074</accession>
    <name>A0A2S5B074_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B074"/>
    <dbReference type="STRING" id="741276.A0A2S5B074"/>
    <dbReference type="OrthoDB" id="2523743at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="254"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="653" mass="70682" checksum="941722AF71A9777A" modified="2018-07-18" version="1">MAALADVAPGPARPHDTALAPDQLLRDPLLLSPAERIQDLISAVERDDLLAVVLVLQNAPAAEVLAQPETGGGHALDVAVRAPIRSVKARKLITECLLFSTLPDFDVEASFASLPVAQQLSVAGVILREWNKGARDEAGDAYSLCEDLTMEEVEEWIATHLESQPANEARNGFEPVRADGTATANEPSTGSPTLSAAEMVKREASLSASPLLSQTAVLPMADEELKPILPVTKSGSVDPPSSTAAPAVGSTALGRLVVRNLPPAVTLVQLKDVIGSAMLGYTLAVSIPQDQATATVEVTTLEAAHEAAARLHGHAIEEGGARRILQTEVVVSVPPPPPAVTKSVPAPAGLASLPSSPPEPRFREDSISSLAPRGSACGVENDSSRREGPSKRPRSGSPGRARDWDPSRYRRTPSPSRYDSRSPVRKSTSPFRTKPLEPKPQLFWYHAVYIPASVSERRLTDDLLEVNITVHDIIVEPVQNRNDRTPSRTAAIAFGSAAEGKKAVYYFTCHPYEGRTVSLKEYRDPRTGAKVPRWDGRVPYVNHRYNLAHPPAFPYARVAIRYGHPARSEERELRTLLISKVSGREIDSLYIESKPAPSSSVVHLQLRNRAAAVDLIKGFDGFVADGHALSVNWDDPDWRMPPPPPRRWRQYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0C8</accession>
    <name>A0A2S5B0C8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_6824</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0C8"/>
    <dbReference type="STRING" id="741276.A0A2S5B0C8"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="243"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="12">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY70240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="423" mass="49432" checksum="67DC6D0FFBFEE793" modified="2018-07-18" version="1">MTEDWSASGVEALRLRLARTKAQEEQLESQEHALVEPFSPIFVYPIYGEEETIFGYKGLDIDYRFASGSLAQYLGVTYEDKFPETANVKADDPEKILYEFIPPDYTKSLEAFTETVEKDGTSFRPLGERVGAYRIKERGQNGKGKGKGKSRAGPILPDRGWELLDLDAADDEDGVRFEGYWTNWDTPGFKEYHRRMQIFALLYIEGASYIDEEDGRWEFVTLFERRKKGDEVSYHFVGYVSFYSFFCWPDTKRLRLAQFVILPLYHKRGHGSALYTLCYRNILSRPEISELTADILSIVEDPSEAFEDMRDKCDLYTLLSENALEGIKAPLDRSWTERIRLKYKLADRQFYRLAEMLLLLTIDPDDEVQQRAIRLTVKKRLFLFNKEQLMQIEDKDERKAKLQETFESVRADYERLTEKFVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0P8</accession>
    <name>A0A2S5B0P8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">A/B superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0P8"/>
    <dbReference type="STRING" id="741276.A0A2S5B0P8"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="42"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="381" mass="43022" checksum="606999D90E7834E2" modified="2018-07-18" version="1">MAPVPSDPASFNHRFVTVPSGHRYHLIDQHPEHWRGPIEQAPTILMAHGFPDLWYGWRYQIAAFAKRGFRVLCPSQLGYHETSKPSSPEKYSFKSVAYDMNGLLDVCGVGKVIVFGHDWGGMVAWRFVDYFPHRVICVACVCTPYMPPAKPGVPFTPTEELVRTKLPNFGYQLFFAREDSNVKIEEALEQFLTTNFSPSVRALASEGGKPMPQFPVKVGEMESRMDGIIEAKRRGESRPVPTDPEYHYYLSTFRKHGLYHPLNWYRTRKINHLEEQAARIGPLPAHIPALMIPAEKDPALPPAMANNPAVKKCFSGNLRVLPPIMGADHWVLQASHSLAPAPFHLGRQDVRYCDEVTRLLAEFVDEVLGGKWQPEDAPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0U4</accession>
    <name>A0A2S5B0U4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0U4"/>
    <dbReference type="STRING" id="741276.A0A2S5B0U4"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="524" mass="59568" checksum="C3B426BCED5851AE" modified="2018-07-18" version="1">MGREVTSVASFRSSLPPHGRSPRRGGAGVSACGRRLPALVILLAAVLALVSLVKRSNANERENVALNQSDVDDADKAMLDLIVRTKEAIQAETPIQDIAAYADRTRVLYELDLFGQTFNESYSHLNASAKALYTRSIDYHHNALQQTLFPYLNRRPEAQRTLAQLGKGYKVPRGIIIPVGNDQMIYAVSLIATLKHVHRTELPIWVVYAGGDDLDPAKRSALRSIHPSVETVDILNFFDEEYVGIHGGGWAIKIFAILASPFQEVIIADADAVFVQNPEVMFDSPGYNETGTYFFRDREIFAGPGQVHDWWRSVMKGRVPSKQMASSRWWNDMASREEMESGVVVFDKRRTSVMYGLVYAGWLNSRLIREEVTYQNTYGDKESFWMAFELCGLPYHLDKEYAGIIGQLTHADRRSHSIDSFIQSDHLFHLDHRGKPLWWNGSLFQEKRVKDRGYLIATHWSPGTTDWICDTEPWSMRVDLRDVQSLEHDTEFLRILTDMIGATVFWEGRFPKLLEQHSATDWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0V1</accession>
    <name>A0A2S5B0V1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000118">
        <property type="protein sequence ID" value="POY70414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0V1"/>
    <dbReference type="STRING" id="741276.A0A2S5B0V1"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="521" mass="56036" checksum="A15D2EF9EF31A309" modified="2018-07-18" version="1">MQYPPSTTMRPPTTRLLSPGMAKDLLPRNVRVRFCSGFFLLGTLNNIIYVVILSAALDLVDQASTPKGIILLVNITPALLVKIGWPYFVPGAPRYGRRVAWCSLLSFIGILIVAMSGSLLPRLCGIAIASFSSGLGEMTYLQKSTLYGSLSPPGRDEEDYGGTAVGWFSSGTGAAGIGGAGLWWIVRGLGVREGLLICSVLPVCMAASHFLLLPHLSVFAALTQPSIPSGGTSTARYDALASSDREASAGNASEEEERGALLHDAEETAEEEGAADEEALEHQLDAKLPSLTTREKIELAKSLVKRYMVPLFFVYLAEYTINSGVAPTLLYKVPTKQSAPVLALVIKNLRDYYPLWQLLYQTFVFISRSSLSILHLPPLPLALLPLPTILQVVILAITTCEAATSFLVALFGEHGATWCTALLVCCEGLCGGAAYVNAFHRLATEEGEDEGSDGEERLHSGSDGFGAKSKARKDQEKEFQISSVGYADTLGITCASFLSTALEPLLCRTQVARGRTYCREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0X6</accession>
    <name>A0A2S5B0X6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0X6"/>
    <dbReference type="STRING" id="741276.A0A2S5B0X6"/>
    <dbReference type="OrthoDB" id="2528404at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="403" mass="42887" checksum="E10E8A8EF3FE4AAA" modified="2018-07-18" version="1">MSLSHNTTLDSLSPVLNFTGPWHSHTDSTAGWYDNSLMYCGGAGTPSSSSEPCEMRVTANATWFGVYGHTNASSGVFDCRLQYDLANGTAVAPLPWVWYDGAHTNGGQSDPITLCNVYNLSPEIYTLVLTVQPAEVSKGIGIDFVTYLSQTQVPGGPNWYSNMNTAVPPTNLRDTTHSPMLPPSTSASSPTATASLSSSHPNPTGVGLGVGLAALLVILVVLTAWFVLRRRRRRTASRSETSSQRGSLHSLQWLPDAHSLRSTIDSPATGSSTCLWLGRPDHLAAAPRSDDTHKMSETRSSDFTIVAGSESPFDDRYAASEAPTAGTYGSDFDHVSVSSTTRVMPPAVVITPASDAGTLGPSPFDDDAALPAVAPLQLSCHALELEEIDLDAPLEHPDSFRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1F3</accession>
    <name>A0A2S5B1F3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_6400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1F3"/>
    <dbReference type="STRING" id="741276.A0A2S5B1F3"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000079">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="561"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="323"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9 10">
        <location>
            <position position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY70622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="878" mass="95401" checksum="88D983B3AF039ED4" modified="2018-07-18" version="1">MTADIPDVDGTRNAGVDDLIKREVFQLPSPFPLLLLYPASARPSYYPDPRMTYTGPPVQQTTSPYWGTAATWEVEIERGGWARVRLHDQAKWRKRGQGYLGEATLGDIWNLLPGDGPREIQLTPELEKGSDNVAVSGRIVLTIKTDGVVRRGASELVPGPGGTASQPNSKLTATPSPSALTEAPQSPLYGFPSHVTATSSPSSATFAGPHSPAHLAAGSTIHRSDVSTANAIVGTTPRRRLTLAEHRRGAAAVSAIDEALGTQSGSLSRSPAPPNGTAQVSTALSPPSEEESLGPLPAGWESRLSSSGRPYFIDHNERKTTWHDPRKVALKKAARMRERMEREVKRAAESGGLAVPAAATEASGSDRPQGGGESSEAFEGAGRSLRPASGRASAVSAHGEQSDAATADIPENVTVATTPGAAASSSTPCSDATTLQASSEAAPLQATQAASNPDPPAAALAALTVSDEQLGALPSGWERRATPSGRAYFVDHNTKTTTWDDPRVPSLNPESDQTKRDFRRKLVYFRSQAPLRPLAGPGGCRLIVRRSNLFEDAFAEIMRPPPEELKKRLMVSFQGEEGVDFGGVSRELFFLLSHAISDPSYCLFEPTEKTSYTLQINPNSGINPEHLDYFLFVGRILGMAIFHRRFVDVHFATSIYKACLDRPIGLEDMALVDVEMFRALTWMAENDITDVLDHDFTTQYDSFGTLETCELVPNGTDTPVTESNKLEYIRLLCEHRLRGRVEKQVEALKRGLGEIVPLKELRVFDEKELELLIGGVETIDVDDWERHTDYRGFTSADPVVQWFWETVKAWPVETKSRLLQFVTGSSRLPVNGFRDLQGSDGPRRFTIEKAAGGERGALPKSHTCFNRIDLPVYDSATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1H5</accession>
    <name>A0A2S5B1H5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NFX1-type zinc finger-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6394</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B1H5"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF445">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="RZ-type" evidence="11">
        <location>
            <begin position="2239"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1074"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1398"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1147"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1401"/>
            <end position="1411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2324" mass="253553" checksum="E91E043155277B8A" modified="2018-07-18" version="1">MLIHASLGTRFRYYLEQISSFSGEVTQLESDCRHKISLLAVVLPKLSQHLLLSPLPTRASRYGRPGMAQARPCYFHQRPGGCRNGSACRFYHGEVPAPGAPAPPRPPPHGPRAFGPPARGPAPRFPGLLSQEEYLAGVPPGTCRFFWTQGTCKRGNRCKYVHVTPTQADSDSDDAASNAASDATVTLLSDDRLTAIASGESSDIVRGPTHFDRGFMNRLLASNGSGYFGSGTFDMCKLAEALLASTEETSTWTLDDAASVVLDFKPASPALARIAEIVASPISSQAGRNRSILPFQRGFIPLVVYLTSNVVKNSIAVNLVNGLYAILVANSAWAQASLAALRDMFARKTTADPNGTGIIGYQPEGFLSITFAFAQLLLELLRRFPDAAVSVPSLGPLVDGITDAFAGFAKDVLSDHPTFLEEPLIRLDVPRRRFAISGVQRSLDILPKVLDCAQIKPVVDALPNAVVPSKVPAGVMSMLRLLMQPLGHLRPAGPRHDNDFADIRRIAILPTAMELTSSAAPFVPANLSGVPYHLEGMEGRLDLLFRLMREDFVGPLRAAVQSLLLDFEHLDDKHNALAALLRRGGGRYRPSLSQKGGDSSDLMVYRDVSLQALDLDRHELHINVQLALPKGFKSSHHIVRNLAQGNLVALLSFEVNRAGRIQDSRNVVIDLGVVSRDLDGTTVKINFFETSHEQRSIYLQSVRDLVARKKVKQAASASSAALYLVELPGFLVGTVEPFLRALQQLSAPEIPFAGVLSAGPPPEGNKIDIAPPLYARNPGFEFDLGCVLAEGSDLPRPSLVMRATDLESVQAAREVLARPGVSKLDATQGQALIDCLTREVALVEGPPGTGKSYLGTEIVRVLHQANVGRILILAFTNHALDETLKHVHKSVTENIVRCGSRSEDPALQAISLHKLSEFSPTQASGTRAWHVGQKVKERKIIEEDILRLCAVAQRPTRVIGWHDLVDYLSRSQSPHLRALMSVPAQVLDIINENKEWTVAGKGKRDRQYGVPDDPETIFAFWRDGVDLDLFARQAAALAAERREMERRRRQAGAAADPALAVTNAFAALSMKSDEEGLPSPIATDLSQPLQSPADPPPPEAPDLVILPDLPSRTSDRTVGELLLVADCWSFSASERTRLVEYYAAAVVEDLAPRLRDLRRNLDKLNAEIKICNSEQRLAILSSASVIGATTNGCANVLDLIKKIRPTVLLVEEAGECLEAQVVANLVPSVQHLICIGDHLQLRPQITSYSLSIDSHRGKIHRHDVSLFERLADLPISMSVLQTQRRMRPEISKLIRNFLYPDLQDAPNVSEYPDVVGMRDNVWFVDHSLQEDEKSALHSSHTNTKEAQWVVDLVRHLVLQGSGRSIAVLTPYLGQVKILRNLLEAQQITTILDERDLGDLEAAQDDEDDDAEAIGPSPRARRCTLGSQVSLRTVDRFQGEEADVVVLSLVRNAATNAEDDDDEMNQAVFARKVGASIGFLKSPNRTNVAISRAKHGLYLFGSASLLRSKADIWESVVADLERDGLVAPSLGAVCPGHPGKTMEIDGPGQLPSLAPFGGCLEPCRCPLPCGHRCPQACHPIDNEHRFVRCIADCASVLDCGHPCEGVCSEKHPPCAFQVPRVALPCGHELLNVPCSKAQQASTLACAEKIEQKLPCGHTVMLRCGANPSLHICEAVCGAALSCAHQACHGRCADCTARRKAGHPAGHVDHAHGKTRSCGHVCSGPCFDHVTHGSCPARCDSPCQRACSHGSCSQLRVKHTCSDPCPSCLQTCETPACGLPCAVPCVALPRDTPCGRTLPACGCPCPSLLGESCEKQVCPIHSAGRDQVVDFMATSSPMTRIRCPASSRWPAVTLSPSRPWMFYARNSDGVWSGLKTPAETKARVCCPTCRTVVTSAATARYRRVIKFAELSHQENLRLLRSQAQYDALSRRVGAFDLSEVLGRAAEVAHPKGPLQIDLEAAGASRERLITESIVATAGTFTDPGFLGLGAALNKNMRKLLRPLFKLHSDIDELVIALSPHARAYEAALVSRYRAEKLSAFQHGRPVSDDQLLRIARLSIGMPPPTTDASFSLKALLAITVRYKVLAAIKALRHRFIDDRERTEARTSDDLIQQLHGLGLAILTSIKHDLRHGRDLARTTMSDRLELQSAFEDGLCSFESAKYVLSWAVRHDGQSPKRASSASRSRQEQSRDMFEKRVKEVLGRHDQPLEAVKEWADRVLRPAMDKICEDWQRFSDSLYREVFYEERAMIVQTLGFATTGHWYTCPNGHRYVIGDCGGAMVRSRCNECGAVIGGSSHQLDETNRTALDFDELAIAAGARREYAWRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1M9</accession>
    <name>A0A2S5B1M9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000102">
        <property type="protein sequence ID" value="POY70687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B1M9"/>
    <dbReference type="OrthoDB" id="2596605at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="955"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1099" mass="113901" checksum="8D8C1FA5DA1EB809" modified="2018-07-18" version="1">MAQDRYKPTLETLPSDVLDQIVETAIDLDSSLGLTLLATAGTSLHAATRRVLARTLVLQDNDDLLAEAEPSITDQRPTAAVDDDGNGXGEPARSIRSLQVTHPELVPSESALASGYPQEPMPPPPLHDAAFFLLVSRLDSLTSFTWSSSRIPPEQLCLALGQATKNLTHFKLDLVASSSSSMAWSPGSPNAHAQSVGSSLFGTSPTATLSSSSSLLSPQQHAQHQRWDAPHLASLPDKLSSLSLSCLSQLGSRSLVAALVESTFAANLERLELAKTLFVDDQVLEAVGDNAKALQVLKVAEMGGTKLSEVGLAHVLEGCTELKELHLEAVEDCTGGCFQSRLTRTTWQKLTPLPPSLRTLRLAYSESGPHKSWILDHLSSLASLLDPVKSSLESLSLTRILPSPEAAVPGSHQLARWPVEALLEPRSFEDKALEALVENHADGAGAGSRHWRELELNLFKVDQDQLKRILEGCPRLRRLRVMFDGPFRNLLALTPSFAACPELQHFLVVIPPEHSPEMVGFTPTEYCAAVSPLYNARSDSAAEAVAAVEGEKATSPPTSPAQSRRRGTLAPGSPSPPSSFCAANKSLESDPAAPTAGSAVSRSCLHHPLPALDALLPPTKDWRRFLKKAHALERVTWTGRGGLGKWDFSQKSGSSLAKVEFRPTKPALMAATTASTSTFGGSYGEEGLTGASGWTPGWNYYAAESPTRTRYRTPSATTTASMSSFDGGQYGFTGSVAAASSSSRRRSSSISLAGSCLSNLSLSPSSSPVSTLTSLATPISIGASGRKGSQSGGLFDVPCSPPEYGFRGAGHMQQQQQQDGGRRRSSASNDSAFGAIGSNAGALGLNLSSPSSSPAMALPLMPSPAEVEGESRHGSSTRDLFGWAADTAAAMAYESNKYGTASPSQELSGVSTRTEADSQTTPAKKPPVLKPLSFAAAVTSSSGPPPSAAPPQPFTPANGKATAPAMARTASASSSGALSASSTSTKGSPSGAGGGTLSSGKGGSGRGSGGGRNKGPSSSGGQRGTAGSGTVGGGQPSSKSKSSSTSPKQDRSSGSSPPKEAAGPNAGGERRASGTGPASGSGSGGRRHRDGGRRREATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1S9</accession>
    <name>A0A2S5B1S9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1S9"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="608" mass="66484" checksum="F6438D980D51B604" modified="2018-07-18" version="1">MSGLDPTEAQFPAIELGISEARAKGQDVKTDDGYAYEEKRADSEISEEDDGLGPAPTDEELATLRRVRGPINVATFLIGFIELAERFSYYGCTVVFTNFIQQPLPEGSTTGSSKAGQTSGALGMGQQASTGLTTFNQFWSYTMPLFGAYIADTYLGRFNTICYAVVVALVGHALLVASAAPSIIKHPNGAIGLFAVAIVIMGVGTGMFKSNISPLIAEQVDQKRRFIKTTKKGERVIVDPAVTIQSLYMYFYLLINLGALAGQLGMVYAEKNIGFYMAFLLPTVVFCLTPIVLFAGRNRYRKTPPAGSVLGKCMRVLTFSVKKTGANPLNWIRAGFWERALPSRYTEAERPSYMTWDDAWVWEVRKGLKACQVFGFLPIYWLTYNQINNNLVSQAAVMNTHGLPNDVLSNLDPFALIILLPVLDLLVYPFFRKIGFNFSPLRRVFAGFIFGRVSCLSLAMVCAAVVQHEIYKRSVCGKYAATCDAEPFVSSLNVWIQTPSYVLIALSEIFASVTTLEYAFTKAPKSMRSMVMSIQLFMTAISSAIGEAFISLSADPLLVENYAVMAGLAFAAAVGFAICFRGLDKEEDQLNSLDAGVTDTKKQAPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B209</accession>
    <name>A0A2S5B209_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B209"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015677265" evidence="3">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="430" mass="44414" checksum="6F6E7804926C3AD7" modified="2018-07-18" version="1">MRPLVLLLVVAAIARQASAHMELVLPPAVRSKSDPQTAEADKDYSMTSPLEADGSNFPAKKYATKAKLDALKPVATLVAGQEFSWNLGGTAVHNGGSCQVAISYDAMETMVVIASWVGGCPLSLPYKFKVPDLPGCDKCFFIWSWFNRTGNREMYQNAAVVSISGKAKQFVGPQIYRINTFGKGVCSSAEGIDIMFPAPGDQVFYANGMSASSPVTEIDCPDWDNKKTVTVTGPGNGPTATAPSGGATGTTGGSAGSKPAGTSTVSTGTKPSSTASGTAPAGTTASATATGTADTTTSATGGSKEADDGTLSGSGGGVVGTNGGAGSGPTSTSSSSSGGLTDLDSDKTPLLFGGGLALLLAVAAGVYCLVQRRDRRSGYRESSSDDDSERAYSHRRARRSRSPRRHSHRQLRHEKRRHDDTDSSSSESTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B231</accession>
    <name>A0A2S5B231_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B231"/>
    <dbReference type="STRING" id="741276.A0A2S5B231"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000020">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF247">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="349"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="497" mass="54597" checksum="C4847A5E94EE180B" modified="2018-07-18" version="1">MGKHGKALKKRRLEQQATRATLTLADGDVSDGEVDLVHLGGLITPAQLAVTVNTLDTLSKHTELLVNKDDAANLRPLRRAAHDFHRTSNQLAGTGNSLSSRISAALTQHRHLDALVLLAELRIRGQTPRLGSLQRWVRDLDAASRDDGSFGDSEVLRVLDAILRCTNGEPDDEEEREGGLVRGKKGQVVVRQRDWVHRTPRDGNVYAEIVAGRFPPPAERESLSSRFHLLHTVPAAERQPPNHHPALLFASAPNAIALSTSPGKAVERFDVPHVPGAFLLTDVLTQDECRSILAHAEAVGFHPDQPVDGDQSVLAHNLYWLADIPFLNTFCNRFLHLCPQLIDNRRVRGINARFRVYRYVPGAIYRPHIDGAWPASGVDPNTCEYLYDSSPKDKPQWSRLTFLIYLNDSFDGGCTTFFLPSSRPSTLNAFPIKPSQGCALVFPHGDSRGSLLHEGSPVGHGGAKYVIRTEVLYDAYDPVPEGVVGGKEGEVDEGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B272</accession>
    <name>A0A2S5B272_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_6060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B272"/>
    <dbReference type="STRING" id="741276.A0A2S5B272"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="220"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="442"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="516"/>
            <end position="517"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY70883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="529" mass="57893" checksum="5AD05353BBA78BBC" modified="2018-07-18" version="1">MASQDWPPQSGEAAQAAVLDLACDWALANGLVLRPQTGSPAATTLGSKPGQLAIHAPFALYPSAFPRRLFQQALALQPVYNQLYADVTVDDRFLEHVIGGAVSKVDEFQGRLYEIWKQVKREGIMQPLSLGLFRSDYLVHAPTDLPAEQHSIKQVEFNTISASFAALSTRVGDLHRYLEQSGAYPPHAALSTSAIPENGALAGLASGLAAAHKAYGNDKAVVMMVIQDHERNAFDQWPLAHELLLTHGVRMVRVPFSELRTTLSHSPAPDYNLLYTPPTPFGSLPTPLEISVVYWRTAYAPTDYYTSAEWDTRLFVEQSRAIKCPSVGMQLAGAKKVQQVLAEPAHLDRFVPDDKDRAFLRESFTDLYPLDDSDNGKIALDKAYRECEKYVLKPQREGGGNNVYRTDIPAFLDQLAEEDKAKGITGTENGDAPRGREGYILMSLIESPQGMEQVLVKAGEARGTRAKVISELGVYGVVLLREDVDNVRGGKAELLVNETVGHLLRTKPVESDEGGVATGFSVIDSPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2I2</accession>
    <name>A0A2S5B2I2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000091">
        <property type="protein sequence ID" value="POY70989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2I2"/>
    <dbReference type="OrthoDB" id="2533496at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="115" mass="12982" checksum="658F1E6451F1FC3F" modified="2018-07-18" version="1">MEPLEQVTSNESTASVELGDYLFCSHCGSEQCKSTQCDFREDNSFTAGVDPEPFREPIEAQFTMNANGEPQCKKHKKTECDSCWGFKKQIAKLTKEGHKRAMNDKKKNPVSNLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2P6</accession>
    <name>A0A2S5B2P6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2P6"/>
    <dbReference type="STRING" id="741276.A0A2S5B2P6"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="57"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="545" mass="59468" checksum="D3E9C2495B5619A4" modified="2018-07-18" version="1">MDESKKVDAGEAAFLETVKREGTEADNLVADARAATEAEHKLTLIQGLKRYPKAVLWSLLISTCIIMTGFDVVLLGSFYGLPQFNEKYGVQLPDGSYTIKTAWQAGLSNGGKIGEIIGLSLNGWAMERFGCRKTSIAALSCLMGFIALSVFAQNIQMLLVGQIFCGCCFGVFETLTVTYAAELAPVSLRPVLTAYVNLCWVIGQIIGSGTLRGVLDMEGQIAYRLPFALQWVWPLPLITGIIFAPESPWWLVRKGNTEQARRTIGRLFSKATDDELDNTLAMMIHTNEFEKSVSAGTAYVDCFKGVDRRRTEIACGVWMIQNLCGSAFMGYSTFFLQQAGVPVSASFDLSIGQYGLGMFGTISSWFLMAKIGRRPLYWGGLTILAILLFIIGGMGSIPRSNKGGSYAVGAMLLIYTAVYDATVGPVCYTLVSEIPSTRLRAKTVVLSRIAYNCVAIINASIMPIFLNTESLNWGAKVGYFWGGMCTLCVVWTYFRCPEPRGRTYGELDVLFANKVSARAFAQTDADQFAGHDGAVAEKVAQTVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2S7</accession>
    <name>A0A2S5B2S7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2S7"/>
    <dbReference type="STRING" id="741276.A0A2S5B2S7"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="375" mass="41536" checksum="A26536F3BAF33AD1" modified="2018-07-18" version="1">MRPNISRLGEIRVPGLVEGLHPPAPFLSLADSVQLLVEFLRSGNGKTTLLTGAGVSVDSGIRAYRGKDGTYTIRKHRPIFYGEFINDEHMRRRYWARSYLGYPPVRRAESNPTHYAMAALQKMGYISSIITQNVDGLHHRAFDDDMTAYLSPPSVKPPDTPTAPLPKLDPPILELHGTLRHAHCLSCHAPTGRDAFQDRLSELNPAWHEFQRDVEAGKREEKLNPDGDIELGPGVKYEDFVVPACDHCGGPMKPRVIFFGESLEPLTRRHSEHLVKESSQLLCAGTSLATFSAYRLVRQVKEQGGAVGLVNVGESRADPIVDWRIGWGGGTGAVFPLAVKELVKHEKRTAIKEEIERMMRQGKIKKVTSGPSAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B309</accession>
    <name>A0A2S5B309_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B309"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16871">
        <property type="entry name" value="ARID_Swi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="753"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="696"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="860"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1163"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1536"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="919"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="995"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1168"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1619" mass="171706" checksum="0A94C25278F4A0C0" modified="2018-07-18" version="1">MTSEQGKPLRLLPQAEVCSAGEGFAMLIIAASGRFTVQLPPTSSSSALLYGQPIYPERPLRPAPKSAGSASLPPKPPPPRHVNSWELENRSLPPRNTPYGSPEVRPRRRSRPPALSMNATPFADPGYEIPLSTPETPDTPYSDRRGSAVSTSSGGSLPHLFARAPSSTSASLKRHSVSSFGAYTINTVGDLSMSSSAPLLDRSSSRRRGSADSLYDTPSAFGRSSAVPVSTTPLATPSPAYFADFSFTKRSTSPAHSLPRLQSNPLGPLRKRLVRSLAASGGSRRLHTEVQLLLELVEALDACVLAYSDGLPTSSPPRDLARLPVRPSLPLLPEGFSENPTTSSVANNAGTHRRMAVEEVRLLVRELFDLVPDTQRYLRAGQYGPLSDIQVTTEALLASLDIADSVEVDPADPADPRTSTGSLAVTSGANWWPARLARDCRSLLEEAGLPSMADGANAAAWLSAATERLPAVARLRSGFLPPRRRWLKYAGAGGAPNGGGPPYQQHQQQQMQMQQMQGMLGQQMMGASGGGGGGALYAGGQGGTMPPFAAGSQPVSTSGLLQQQLAQQAAAMAAQNVNYHAGQQQQNAARPVYANQQPAYAASPGSGYPQQSFAPQQRQPGPPPLPGAFMTPAAYPQSQPQQPVSATRAAATSASSMTSQELQEVLRGVALQGMTHERFGSLLPIQQAALRELMARQRAQQQGQLARGAPPAGPQGTPLRTMPTNQGANGSSAAPNRPAPIPNGTPAPAAPLSGPQLAFLKTLADFYAKRGQPFAGPPNIEGRVVDLARMFAAVQQAGGSAMVSTQGRWGHVATSLGFIAPTSELHPPDRLAALEQAYQRLLLPFEQFWVQAQRARQAGTAGSPAANAMSPPSNGFPSTPGSAPSPYAAPSPAAVATPKAGPKQTIQARRIERQASEMAQQQNAQAIASHSASSQPALGGAPAAAVASPLPATAPTRAQPAPTTLQAPPQIRPRTGDSSARPPPSSAMAPSQNEAIKDVKTEEDPKPIATKRRPSRTEVPTVKPRPDTSRPLDGPPSATAPPTEKVAVPAEPPRRKRRRIAYRPYAKPADTFGGVEHADQVLVSAERIRQSRQLGDLGLVDVHALTMSLRCRVASEVSYALNTLAVVALHMSNDSTGTSATTFPLDKCPDLFEELLDLLEETAFGSQDEPRPQRRDDGVGTSSVVRPSTSQASEPRSYLELFRLIEAEKGDVAYTEARATDRRSRDAGTTGLAPAAIIVAVMNLLRGLTITERNMRFAAQEPRLARLLFRVSALPLSSGQSGSSGSAARPSGLPSQDLLAVRKVAIELLAHISLDVELDSHPGETTRDAVELVLFFLRDAALHKEPFTFDLCSALPSLERIPQPHAKPAQQSPTVLPYLGFALATSARLFLRDGNRSAVASLLGEDEWHDLFVDLVAILPITEKDFQVMTYESGLIYMHSIVVSLYNFTCVASTAIRTRLRRHPKITRAFLRMVRRLAGTQVTRSDDDIYQQIAHRALAILRLLNDGATSARTSRNAAAGPNADLPWFGLSMSGLDEESDDSAGHDSPILPTSSGEDGAETPGVVPAGANDADRRAAPILAGEARHLLEHMSQGMMPLVIPSLIALAGTVGGRSGRKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3B1</accession>
    <name>A0A2S5B3B1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EB1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5547</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3B1"/>
    <dbReference type="STRING" id="741276.A0A2S5B3B1"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="12">
        <location>
            <begin position="209"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33750" checksum="59BD9FF631A2880C" modified="2018-07-18" version="1">MAGESRTELIQFTNDLLGLNYTKIEQCGELDCPEKALSARTAPCADLARTGAAYCQIMDSIFGDVAMNRVKFDAKQEYEYLSNFRILQNSFKVHGIDKPIPVERLVRCKMQDNLEFMQWLKRFWDMNFPGGDYDPIARRGGAGARAPSTSSSAGVGAAAARAPVASTSARRPPAARPAPARGPPPVGAAAGRAPLGAGRVSAARTSSAAGGVDPAALEALNAQMSEMKLSVEGLEKERDFYFNKLREIEIIIGARLEVAEAPAEEGAVPVTEDEKETLLQMQQILYSTEEGFEVPQEGEEGDLVANEEEETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3H3</accession>
    <name>A0A2S5B3H3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_5650</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3H3"/>
    <dbReference type="STRING" id="741276.A0A2S5B3H3"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="492"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="708"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="376"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="911"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="957"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY71338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110036" checksum="93C19DEEC83B13AD" modified="2018-07-18" version="1">MATKRVQLDSLSDSGSASSGPAPKRARRAAATAANTANASASGSASNVIEVGSSDSDESDEGRNPDRSYKVNRTEAAADYASDYDLDEEAVADEDDSERSDEDEFRPEKRASGAAANKGKGKGKGPAKPRAKGKGKAAAPPAANAGTKIRFTLGGGGGGDSSSASASTSRTPTLMTPGVAAEASGVIPGTSFRQDRDYGYLPLRPDQASRPFYIVPSTGHIILENFHPLAKYATDFLVAIAEPVSRPKHIHEYKLTPHSLYAAVSVGLETENIIEVLNRMSKVPVPDELCDFIRECTHSYGKVKMVLKQNKHFVESSDPETLRILLRDKVIAESRVPPEEQRARDGVAADGSGVPPGGTATYGLEKEKAPTRAGLVIPGTSKQVAANGKGDAANGGANGEPANSGRTQEEEDLFTAVVGLEKEDDMDDDDEVHSFEIRESEIEAVKRRCLDLDYRMMEEYDFRHDEVNPTLEIDLKPSAALRPYQEKSLGKMFGNGRARSGIIVLPCGAGKTLVGITAATTIRKSCIVLCTSSVSVMQWRQQFLQWSTIKESAISVFTADQKEKFSGEAGIVVSTYSMVANRQKRSHDSQKMMDFLTSREWGFILLDEVHVVPAAMFRRVVTKIKAHTKLGLTATLVREDDKIDDLNFLIGPKLYEANWMDLAENGHIAKVQCAEVWCDMTPEFYREYLRESSRKKMLLYCMNPRKFQACQFLIQYHENRGDKIIVFSDNVYALEAYAKKLGKLYIHGGTPQVERMRILQNFQHNPIVNTIFLSKVGDTSIDLPEATCLIQISSHFGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKEYVQNPYLHHMGSRADRSSRPISTQEMYYSSKRQGFLVDQGYAFKVITSLDGLEQLDNLVYPTKAEQIELLQSVLLANETDGDLGTEDASKDVGSGRYNSPAPGAGGLQATRIAGSLQALSGGQSMAYSERQKSANKQLSKDAKSNRHNLFKKRDEAAKKRAKDRAAGGGGGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3M6</accession>
    <name>A0A2S5B3M6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3M6"/>
    <dbReference type="STRING" id="741276.A0A2S5B3M6"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34370" checksum="409059549EF57CE6" modified="2018-07-18" version="1">MLEKVEQRRAARLTGKSRLWLSRNRTRTRLTPPAHLWELAADVFERLGSTQSRDNTFQPHHSLHRPPAPADLTTSHLVAAGAHLGHARQHSHRSALPLVYGTRAGVSYIDLRQTLPALRRAAQVVKGVVERDGKVLFVGSLKGTESAVWVNAKRLGENGYGVTKWLPGTISNAKEVFGWSEIPATVNAAEAVDAAAANPNGRATGRDRRSAAPAKLTPLSFKPDLLVLLSPTLNRHALREATQNQVPTIGIIDTDLDPRSVTYAIPANDDSPRAVELIAGVLGMAGKDGLRAKNERVAREAARLASFDRRQSREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3Q4</accession>
    <name>A0A2S5B3Q4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3Q4"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="337" mass="37447" checksum="0DEABEBB02FA603F" modified="2018-07-18" version="1">MKAPQAAPTADAPSRTLTSPDYVLRKEPVQLSVLPGYFHQSEPSYNSSCDYLDQSFGLIEDGADRWQRLRQEVGRLNGEASQGTSVKVFFFGRHGEGWHNVAERYYGTSEWDCYWSKQNGDGNMTWGPDALLTDVGVQQAKRVHRAWKRERLAGVPVPDSLYSSPLSRAASTCQITFDKLALSSPRFMEILRQVLLARRETLGVHTCDKRQRKSWLMGAYPSFGFLEPFSEKDELWRPDVRESDAEQDRRSRMALDEIFSRDSAPFVSITAHGGVIASILRAVGHPPVQTQTGSVTPVVVKAVRSRSDITADSSAFVALPRQAASAGAAQLVLDRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3X0</accession>
    <name>A0A2S5B3X0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleoporin Nup186/Nup192/Nup205</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B3X0"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2082" mass="227060" checksum="659855487628B51D" modified="2018-07-18" version="1">MDRFERLRVFLDSALLNPPATPDAALLSRLQLKLERARPAFLDFLDTPGKDAKQREQLNKGTFTYVATGSSYPAGPALVKDILFLSDALAMSEELAASLVAYGINAKPRAGSGRAEAGLLVHLEERASLLLCLHAIWRGALSADERVVNSGIQRVFEREVEELTRGRGTEVTLGSAAKAKGSWVEKVIKALDDCKSEADKLRSSLSTPAPSIGAIVPAGQAPSFPDEVTQMRIQRYDEERQLVGQLLFLIGAGSGMSKDDIRLLIRQLSSTTADDTAAVYILIALLAALDVSTEVAAQQANDLFTDANFISQVKGDLNGNWATPALRAVVQLQWSIFLDVAAREVPGFEKDGGEEVDALTWQAIDAGVFAFLGRSVLACKGSHEISEMWGAVGADLSPLGGDVEVDPTFRDYVVEQVETLVVEVITNRISILRKLRNREEDTLSASHRGGARRTSGGTVDSQPPAPRHDLEAFFLLVATIYRNNDDAGLRFWESESLDPNTNALVLDPTNTRLAAFLRWGSECRPPAMMRAFYEMIASLASGAQCATYAYEFLSLGSALDGSGAPSSNCSWAALFGALEFYINNLPDRPLEVDANSEGLNEIPPEEVPLLRAFVHLLRQVVAYSDVARATLHDNQRHKPVATLFALTTRSVPIDLKASLLSAIEAFARPGGAFAVDVARKTWLALEQSQILPTWSLASLKQTNRMHRPDELVGGILTELEEVEAPNHVFPESTAFVRLLSSLVHVRTSSDPLRRSVDLETHAIPDNLGAPNRPAGLEPYVSFVVEDVLLKAGSREYADPRERWQVTDACLAFVEKCLAAFDLGPFLAWATNGGRPTSGSVSPLHLVAQHPGFDVLTRILSGSALLETILTIVTAGYDSIRNNLAKTSLFTRCMVRCLRIIRRVLDVQTAFLEVVLPALSDSGMRLSADNLARLKALSPIDQSFLYHSEVVVQIALLVACEEDDEIALLAVGILRTVADSPYFDVQQRFPDQSRTKLNRLVGLLQASPETLRIQEAFIGRLEEDLPESELEAPEWTQPIGDAEVERMKIEDPAAFRRAMKTAVLDLFLAGTRPDRSAPNVSHLLLGFDLRARPDEMEIEDPEAADTARTTLHVVLELLAQNVSRDDADAQTSILVRHPALASRCYRLVRQLCMQPFTSAVMSRYVRNREQYFLRQSLALPFAMPSASSGALGHVQYADGKEILTSCPAISAILESEAWLLEAATLELSVLATGNDTRRAGEIIAAYLESPSAIDDDVPEYLERDGGLEQGLPRILEIFHALDFAWSDAIVPIAQPLTLFGDLRFDSCLHRNAAGCETYDFTSLLSLLNAARRELQNRGFLNTPQQQEAVKQETRAIVETLVVENHRREIQFARYQALKAWRNLLDIILVKAFHLLSAEGRHSLLLDLLGAVLPPLTAPSVDASVSELLSGAAVLLATKLRDEGVSLLFVDAGETVESISPERLHAILRAILQAILQPGVSLTVRGNLYATLLGYLQYSQRIASLSPALSRSLDEQTTGSRAATVDDDVFSIGGSTAAGEEAGPRRSRRSALEHGNFSILSASFERLLPIVCRDAAVGHEVWRTVAFTVLDAFVTLAQAGRVAGKMLAILAKQGYLGSFVTALKDAEAGLLAVLQPDPSSLNALYVYEAQMSFLIRIAAVREGAEKLLGAELLTRLAECEYLGARPLADSDSMEFDGFIPPATERHHQLLLPALQLVANTVISFGSDTQVVVRQLFGFIAAQRENLLVALKDCAAQQTVPLLREAHLIVTLMGIVLPSISDDGLATLSSFGGLHSSVLALSARIWSSQDWVSRVLPSNDVEREEDQTLVLALRGSATVFGDKVETLAESLQSALLAYENLATRKRPGSDAFRPVLLPTLKFGENSASGQSFGSMGAFLRDVARVLEARLHEVDSLAELLDSFDSRSLDEIEDIFDFPADDSSDADRRGKIAQELQTLATRSRAKLETSMNLLEAALLLYQRHVAFFLDSDRADKDGSGRPDVGLGLAVSLKARKDPNAMLSVSQYNLPTLREDLAEEVSRLADKLNSLSFTQRNAGSSYAQREAFVGIVTRRLQELLLLGGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3Z0</accession>
    <name>A0A2S5B3Z0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3Z0"/>
    <dbReference type="OrthoDB" id="10443452at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="570" mass="61413" checksum="12E6D5358D1D422E" modified="2018-07-18" version="1">MTLPIAELYGRPRSPLLQESSPSPPAPSLRPASSTSNLDYDRLNASSDRGSYSTYRTSVSFKPTDDPFAAKTPTAERTPIRSHSRNDGEGGPTSLDPLHEEDQSSVGRGTPSEPRHSQGKPRRRASFLRSFVDALPFKPRRTRSPAHLSISAPLRHSVQPSVTPPPTRIPLAQVTATTSPNRSGHLESQRYPSGSSSLRQASVTKRSSLGSLFRPSSRLSLRRDPQLEKVDEHEVGLALTTDETASSTRNMALPSAKSPALTPSTPRLNGMIPQIAMTAPTPAKPNARLRPRPPSRARSTGQLGGSGNVLDEEELLLRTIAALMHSSGVRPTMFTLLRRRGTLASDAPGALAFEAVKRYLTGVAEQRYLLEDDVASTNRRLDLLEDENEGWRKAIAILVERASEESRPTEHASAARQEGTLDLTGIVSASSSASELADLFSELRQERAALQHLAQAVSSGLRALERATSDSQGGPLLTSPPVTTADSSANPPSCTSTPLRQQARPFRPLTLTPPGVADSPIPTYGRVTVRKGRSTKTTPDEEDSTAFTVHLIPMKRIPASRSKTTCGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B450</accession>
    <name>A0A2S5B450_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyl-D-glucosamine kinase</fullName>
            <ecNumber evidence="2">2.7.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GlcNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type N-acetylglucosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.59" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000080">
        <property type="protein sequence ID" value="POY71559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B450"/>
    <dbReference type="STRING" id="741276.A0A2S5B450"/>
    <dbReference type="OrthoDB" id="311172at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd24007">
        <property type="entry name" value="ASKHA_NBD_eukNAGK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052519">
        <property type="entry name" value="Euk-type_GlcNAc_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190:SF3">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase BadF/BadG/BcrA/BcrD type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="362" mass="38119" checksum="D5601325CA5212FD" modified="2018-07-18" version="1">MPSARLPEWYLCVDAGGTSCKIAVASSLDPERVVTATGGPCNVKAIGPKGAIAVILKAVQDALAQIPELDFDARADPPPPLPARFFSRVWLGLAGVLHQKDISDIAPFARDAFGFSTALRITNDGYLLAAPSLALSHIDSCVALVAGTGSVNLTFRKVENEVELSGMSGGWGYLLGDEGSAFAVGRLAMRQLLTDYDARTTASLRLPATTLQPILPLFTALLASLGAADAATMVDKTYSDSNELERKLWIAEGSRVVYDYAFDRIPGVDAPSRAIALQIVREAVAPIVETVVSLTKDGSDIDPARTLLSLGGGMYSAEGYRALLLGALKARGIAFAEVRLVQSAAEEGAKALRAQDARTDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4J5</accession>
    <name>A0A2S5B4J5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4J5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4J5"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="146" mass="15790" checksum="3882025F9B196E24" modified="2018-07-18" version="1">MPPKSRSSSSKAATQKAALGFSATKKGVPPSSKQQGAAAKATKVSAQTNGKATTKKSDLAGLYPRLYKEALRKMGPPIHRDEMDDIEIILRVFDADEEYGPCSRVWSAGSAPRSSAFNRIPRQIGEILRSEEGKSTKAYSDSIFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4M7</accession>
    <name>A0A2S5B4M7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5088</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4M7"/>
    <dbReference type="STRING" id="741276.A0A2S5B4M7"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF365">
        <property type="entry name" value="ENDOCHITINASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="64"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="457" mass="50487" checksum="28B060F0748CB520" modified="2018-07-18" version="1">MPISDGQLYKDPATTQTRLRALRRFLTLATLLPLVAAWLLFQRRPGALRLTTTAMASVPRPNGRVSVGYFTNWGIYGRAYKPEAIPADDLTHVLYSFAAVKEDGEVALTDAWADEQIHYGDDKWDEPGGPHLYGNLKALYRLKQQHRHLKVLLSIGGWTHSENGKFARPISSSPGREKFAATAVELVKDYGLDGLDVDFEYPQNDTEARDYVELLRLLRHGLDGLQQKLGVQPPNGFELTVAAPCGPSQIETLRIREMDQYLSFWNLMAYDYAGSWETIANHHAAIFGASPTSVCTDRALRMYTDPARGGVHPSKLVLGMPLYGRSFTNTDGPGTPFQGVGQGSWEAGSYDYKALPLPGSTTAFDARLVASSCYNPSTREWISYDSPEAAAAKATFIDVNGLGGAMWWELSGDRKRGDGGLVAIVRDGMAGSGPIDSRPNWLDYRTSKWENMRKGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4M9</accession>
    <name>A0A2S5B4M9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-hydroxyacid dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4M9"/>
    <dbReference type="STRING" id="741276.A0A2S5B4M9"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF289">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="116"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="174"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42238" checksum="837CD10F37413078" modified="2018-07-18" version="1">MACSSAPAHLLRSRPRAQLLGPARRCLPLAPLGHTRLFSMTPSVQDVSTSNGSGKPVVLLMDEIKLAGDLLRDLSQKWEVQPLSSTNRSQFIDDCRTKYGHAQGIYRHFKGPSTKVTGLFDAELVAALPDSLKFIAHNGAGYDQINVDACTKRRIQVSNVPVAVDGATADTALFLMLGALRQFGKAQHNLRDGAFNAGLPLSNDPEGKTLGIVGMGGIGRAFARRARALGMSIVYHNRNRLSPDLEDGATYVSSLDELLSTSDVVSLNLPLNAHTKHTMGAEQFRRMKGSAILINTARGGVVDEKALVAALEQGEIVGCGLDVYENEPRIEEGLLRLEKEGKAFLLPHVGTLTVETQREMESVCLRQLDHGFKTGKFRFWVPEQKGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4U5</accession>
    <name>A0A2S5B4U5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Chitinase</fullName>
            <ecNumber evidence="10">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4U5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4U5"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="548" mass="59769" checksum="6A2116CD3467B038" modified="2018-07-18" version="1">MVKTYTLKQVAEHASVDKGAWIVIDGAVYDVTSFLSEHPGGKKILLAQAGKDATEKFWQFHSKKVLDEQAKPLLIGQIGNEGHSSDQVKDFEDAVLAKIETAEQVPAEAAAEEDEDTTYFGDLVPFGDPQWYQDWASPYYNDSHRKVRSAMRKFTDTWLTPNALAWDQAKEIPPEEYKRIANAGILAGVAAGATGWPTEYAQGIPVPGGIEPEEWDAFHNLIVIDELSRCGSGGILYGLLGGFGISIGPIMHAGSDDLRRRIVPALLRGEKRSCLAITEPEGGSDVANIVTEAKKTEDGKHYIVNGVKKWITGGVKSDFFVTAVRTGAKGMGGISLVVIERSEGVTTRKMDCMGVWASGTSYVTLEDVKVPVANILGRENKGFPVIMSNFNGERAGIAIQANRFARVCLEESIKYANKRKTFGKKLIEHPVIRAKLASMSQKVEATHAWIETVVYQSTQYDAETITVRGGGTMALLKAAATETFEFCAREACQIFGGLAYSRGGQGEKIERLYRDAKAYSIPGGSFEIMQDLGIRQSVKIAEIMGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B504</accession>
    <name>A0A2S5B504_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B504"/>
    <dbReference type="STRING" id="741276.A0A2S5B504"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="61739" checksum="E7C3CEBB09B23AFB" modified="2018-07-18" version="1">MELEISGSVLKNFRSALQCLSKLGEDLDFSCAPDRLSVSTVNSSRTAFGIVHFYPRFFARYDIADQDRNGTAAASRRRRSHTSGASQAQAKFRFSVTGKVRCAPFRCRGRAHTHRRHVQALLSTLRPRSASTVDSCILSVHDSEDPQTHHEPGVDSGECRIIVSLLCQHGVRKKHSLTYSTPAVQSWARFDLNTATCNWTASSRVLKDWMAHFHERTGGAGAGGGGGAGGSGTDEVTFYCSRGECRLKSFNDVDRSGPSHDVFATRSLSTEVTVDTEDFDAYNVPMRQVVTFAQREFKVTLAPAITNFAEPLQTTLTARFSGGGRPIMFSLDGEGGAFQAVFVVATTDFDSGPADGDGADGVKREKSESVAQHFAVAGGAPARSASAAAGTSSQNGSGSRNGRSLFNAPTPSPAPPNFRAGPSVDKGKGKAPVQEPDPTDYAAIFGDDDEFDDAFFAEVDRATQEAMEKQSQRVRLAQSQTDGQPHSGIGQGHSSAFAPISTGAIERGQRDESEALGYQQDHEGAENDLGGHDEGFVWQDVETQLGPTQREPSASGSDGEDGRSVKRARWNLLGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5G3</accession>
    <name>A0A2S5B5G3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4984</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5G3"/>
    <dbReference type="STRING" id="741276.A0A2S5B5G3"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF46">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="117"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="375" mass="40774" checksum="50D7D79A900F5BB1" modified="2018-07-18" version="1">MLTGSSIKLLTGNSHPELAQMVAQKLGIPLTECTVKKFSDNETSVSIGESVREEDVFILQTGFNPSPFPFGAKARHYGQDGVADQERPGTPLPPLANHHDLMSRPTSPSKPSPLPLNDPNDLLMELLILISACKTASARRITAVIPCFPYARMDRKDKSRSPITAKLVANMLQIAGCDHVITMDLHASQIQGFFEVPVDNLWTEPSMVRWVKENIADWKNAIIVSPDAGGAKRATNLADRLDCDFALINRNRAKGDGPDSEGKMELLVGDVKDKIAILIDDMADTGGTIKTATQTLANHGAKEVYALVSHGLLSGESLQELSKMPITKVVVTNTVSQAEHLKQANGKLEIMDISPVIAESIRRTHNGESISLLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5I0</accession>
    <name>A0A2S5B5I0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the CWC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5I0"/>
    <dbReference type="STRING" id="741276.A0A2S5B5I0"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="378" mass="41259" checksum="6C69B90153BF6E82" modified="2018-07-18" version="1">MSSDAPVTFIKKRKGAPAGLRKKPTLGGDDHASSSSSSQPATSEVIHATKRAVASHLIQGTGNKRRKTQQDAAGDLSDSGDDAGDDGKKDSFAVRHSTERRAQRRRSESPPAWMSSEQVKELKRDKNAAPEEEIAEDGLYHGSSKQRNQVPKAAGPVKAGPTNVRQITVVDYQPDVCKDYKETGFCGFGDTCKFLHDRGDYLHGWQLDNSFLSNQAASGSFMAKQRARDGDDASDADSDTDDLPFACLICRKPFGPDPVVTLCGHYFDSACAIKRFAKTGKCFACGSSTNGVFNRATKLVARQKEREALNAKAREEEEGEAAGDDDEGIEIEGLAEVKDDAPTSRTSRRQRSPSESEGEYEEEVENEVPRRRPIIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B625</accession>
    <name>A0A2S5B625_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B625"/>
    <dbReference type="OrthoDB" id="3246235at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="53785" checksum="8FA937595C6BA079" modified="2018-07-18" version="1">MSASADEKALDTAEKPTALSTESPTADEAAPKWVEAYESTLTKLPPALAARLPSSSAAVRSVALAQDKLGGLGDASKQQWETASKYTAAKAAALREAASTKSSEARVEWMKQAWSVTNETQLPLNISLNQVGPLYFEVVAPGDTFERRIPNVWHLLEVRPYTSKATAYNAWSTTWPILCTAGPVVAATSLIAIPIVAVATGGSALAALSAFGSSISAAVSSATAGAVEGVTATAATVTAAAAKASRLPGAGQVKGKLADAAKSMVREQVGKQEVQQRVIRYLTKSGTVTPHTDAYGAKAIGAAGAEAEAATLELEGDVVQTRDSTGKKLDEVDVTGYDMEKVLACETGHSSTDKALTKAFKRLSFKTKFGEFKAQDNPVLRIVGGPELETRPGEPSLFKPNPPPRQILVFHPFLLIRRNDVVAEPISPEEVPPTENESRVIEEAKVVETYAEAEKAVKKTEQGESPGQAVEEALAEAHADGTDLVTPEQAHEGAAPTGEAADAKKGWFGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6F2</accession>
    <name>A0A2S5B6F2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6F2"/>
    <dbReference type="STRING" id="741276.A0A2S5B6F2"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="447"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="528"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="628"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="670"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="712"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="859"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1014" mass="111534" checksum="475F77112783F7CD" modified="2018-07-18" version="1">MVQTYSRHGPTEAFGVISSGSAVYDGRKAYCPALEDVLVWDVKKGEQVAMWHETGLRALVTCIVRSPVDWEAFAVGYADGSVRIWNSKSQTVTVTFNGHKTAVSALAWDADGTRLATGAKDTDIIVWDVVGEVGLFRLRGHREQITALAFVAARPEGTEAATASTSAEPSSSTATTVSTAKPATHLLSSSKDTFIKLWNLTTQHCIETIVGHRSEAWSFAYDAASNVLVSGGGEGEVKCWKVDNDVLSSGVAAMVDEDTAAAAAAAPGKKKLKRAISPIAALSLPNPNHTHNITQISLHPTLPVLAIHSGERAIDVFRLRTEEELRKKLARRRRRDREKKEKGKAAKGKGKAKAVEGEDDDDAEMDSDEAVNDGEIEWRDRLAVWSTVRASGKVRSFSFAPETQKSKGEVQIMASLANNSLEVFNLPPPASSKAPAVEPIKLLSLDLPGHRSDVRCLAVSSDDQLIASASHGSLKLWNVKTTKCVRTMDCGYAICCSFLPGDRHIVVGTKSGELLLYDLSSSSLLETFAAHTGPLWSLHVRPDKRGLVTGSADKDVKFWDFEVREVPSEVEGGPPTRVLTLAHVKTLKMTDDVLAVKYSPDGRLLAVSLLDSTVKVFYADTLKFFLSLYGHKLPVLAIDISSDSKLIVTCSADKNVKIWGLDFGDCHRSLFAHDESVMQVAFERGSHLFWSVGKDKMVKYWDGDKFECIQKLPGHSGEIWALAVSNKANFVVTGSHDKSIRIWEKTDEPLFLEEERERELEEMYSNTTNARGDRDELRVLPSGEEVPQAESTEVTKSTTETLMAGERIMEALELSEADQTALRAFQEEVRRMPNEEMAKRVLAPSRNAVFSMYDNCSAEEYVLKVVRAIPPAQLQDALLVLPFGNVVQLIEHIDVWAHKESPGWQLALTSRVLFFLLRTHHSQIVATRALRPTMVALKGHLRDALKKQKNTLGYNLAALKYLQRQHESNKVAEFYEKDVLGTGVTGGGGMADEKDVRAMIEASAKKRKRATMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6I9</accession>
    <name>A0A2S5B6I9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Branched-chain-amino-acid transaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000049">
        <property type="protein sequence ID" value="POY72403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6I9"/>
    <dbReference type="STRING" id="741276.A0A2S5B6I9"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24551" checksum="C82E00F48906BB17" modified="2018-07-18" version="1">MFPVHWYLIPSLRDASPVGPYYSTGFKPVKLYATTKDVRAWPGGTGGYKLGSNYAAGVVPQQQAAALGYQQILWLFGPEHRLTEVGTMNLGVAFSRNDGSVEFVTPPLDDMILPGVTRDSILSLLRDHESGKNRLEGLPDKLIVSERQLTMPDIVAASKDGTLREIFGCGTAAIVSPVDGIGYQDELIKVPVGEDGCGDIARVMLREIVGRQTGDILSEWSFPVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6L4</accession>
    <name>A0A2S5B6L4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_4566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000049">
        <property type="protein sequence ID" value="POY72409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6L4"/>
    <dbReference type="STRING" id="741276.A0A2S5B6L4"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="13">
        <location>
            <begin position="197"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY72409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="582" mass="63032" checksum="F118A009085E8C8C" modified="2018-07-18" version="1">MSAMYKLDQNDSALYPPTGSSTHLAPENQDRMSGQRSSFATSRVGRKRRSPWVWVAAAVAAVIVILAAVLGGVLGSRATSGDNKNNSVGAKVNAGAASGASTTGTASAASTSLPAGASKVAITDLPAWNWGQNKSIGMCLGNTYILEKWMAPDWFNATVNAVQPGAGATAMDEWSFMEILGQERGRAALLEHFETWATEDDIETMFQYGINHLRIPTGFWAWIPTIEGEPYLNDTSLYQAQIERVLGYLYDRNMYAIIDCHGLPGSQNGEQSSGHLTTEPSWFGGNASTETPNQIRSDQMVVAITEWLAKTPYRSVVTGIEVINEPRPYTPDQIVQLKNYYERSYATIQKSAWPVATFLHNGYTNLTFWQDFAAAHATQPPSMVMVDHPYPGNFPPQNDSSNILSQICTAADRYLNYPIPICIDEWSLYTGVKDQAFEKQFYEQQLVTWAWSAGGMYWSWKLETSQQDLAAGLDYSQYSFVTLLKNNSATIDKPSAFGQNGTTSMGAAEAYLSALAAQISPNCGTAPSNVAPYATGSVSAWTAEQSARSSAAGQTLTATVTTSTAASATATARAKRAVPMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6M6</accession>
    <name>A0A2S5B6M6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6M6"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="1">
        <location>
            <begin position="87"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="257" mass="28296" checksum="79BC5873CEDD65B6" modified="2018-07-18" version="1">MVPPSILTMRELTEKDLPPAPDSVEYSAWVDAAVTASLKLVASVPVAAATSDDAVWVKGKIYNGAQTYSTRSAEGIPGAGETEGFKWHTRQSIHDVAQLSYDDFERGLLIDHSLNEAKYIESCTEAKRVQVVKQGELEVWQTLYRLPFPASNRDFAFAILTVRVPESAATIPGLRAFLVVSIPFAHPREHGYTRGRYVSVEHVAEMPDGKIQWTMAVSSSAGGMVPKMISEHSMPSKISEDVPSFVKWAKKEFRAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6T5</accession>
    <name>A0A2S5B6T5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative peptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6T5"/>
    <dbReference type="STRING" id="741276.A0A2S5B6T5"/>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015754079" description="Putative peptidase domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Putative peptidase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="341" mass="36521" checksum="F6083EFF471CBCC8" modified="2018-07-18" version="1">MLPTTTLCAALLLVASAQAAPFLPSARALVKRAESASDASTNKHARTNMTEVQIHESCDAGQAHFIRAGLDDMNTISKHAYERILKYGENDELYRKYFGTASSASAAGFYAQLLYGNKPGVLFRCDNPDGNCDEVTAEGPWAGHYRGKNATEQTVICPPTYTRRKQLATLCWDGVEIGSEPPARWLATDFMHRLTHVPSITYGHIDHAADSLGGVLELAAHNDSRTAFNQNTFQFYALDAYAYDVVWPGKSCVTANPPHDEASHSAPASTSSSAAAAAATTASAEHNHSDDAHAHSATSTATRTAAAACHTHADGEVRRCACLSLRLAQLTLACTIQVHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B772</accession>
    <name>A0A2S5B772_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B772"/>
    <dbReference type="STRING" id="741276.A0A2S5B772"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35498" checksum="DE24D35D70DCB748" modified="2018-07-18" version="1">MVWPFSSLASKAGFSNGRHWEPETGLADLTGKVAAITGANEGIGFITAQELHKKGCKIFLLCRNEEKAQNAIDRLNKTTPGQSNNLVFVKFDLTDIPSAKAAAEAIQAQTSRLDILVNNAGIMAWPYEVKNGVEIQFSNHVGHFALTTKLLPLMIQTSKEPGSSVRIVNVSSKAHEFSPKPDFSSIEAANQEMKNTWQRYGQSKLANVLFTTALQERVQNEKIYVNTLHPGNIATTLTRGPSASYGKLVDIMEPLWKMFGMTPFAGAKTQLYLAGSPEVEEKNYRGQYFVPIATPGDTTDYAKDRELAEQLWKLSEEIVSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B788</accession>
    <name>A0A2S5B788_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Crossover junction endonuclease EME1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_4418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B788"/>
    <dbReference type="STRING" id="741276.A0A2S5B788"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000004">
        <property type="entry name" value="Crossover junction endonuclease EME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="204"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY72591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="738" mass="79644" checksum="9A9837EB94AC0F29" modified="2018-07-18" version="1">MVDSSDDEIEILSASQKPARPPTLSPVDAFTHASNPAPGLALASSRNRANQNGQGALSKATGQVLHLSDGSDDDDLPAPFRASSRQPAPRDVRYKPDAIDLSTSEDLVAPGNVWSGGAVAGPSRVRGLGGVPVARSISLTGAPSSSETVSGFARNPSARAFTLAACTLHPQPYESPQLQRAHTLALMSEFDHAITSSSSPHAFIAGGSRPLPPHALSSSPAVRAQKNLSSDPFGDLRTPIPAAAPSVSAARAGEPKKAQPAPRAPAIDRDYDPWADILEDSAKKGKPSKSNGAAAKGKRKAADGGAEPRKRSVSAVAPEVDQAGGKRGKTPRLSAEPGATAGMTKTELKRLETADRMKLREANTLRAGDKKVTTAELTMHISGTAFRAANDDIEQDGLDDDTGRKRSKAPRKATKSSPWLEISRDVEKRLKEYACNIEAPDSSSAANVLECEGAVRWTRICDRMWSEDRKMYIPLVGDERIVVEEDSRLIFLSAFDLSQHVADSTLVNHVTTVQSHLPPHVNLFIMLYGLNALARDLERARQEAYRNQVRAASGDDAVGAAKAVKLPGIGEKQPSKDDLELALIRLQMQTRCMLVNVDKVSDAVDWLEQITFDVGQKPYQRLKHSHIAMLGTSEDKVVSGKDLQDTYIKMLASLPRVTEAMAKGIVAEYPTLRKLYESYERCRDEREMKEMLVGIGKGRNLDGTATHRAIGKDMSANIYRVFMGRESFSLRSSMLNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7A4</accession>
    <name>A0A2S5B7A4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4474</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7A4"/>
    <dbReference type="STRING" id="741276.A0A2S5B7A4"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="359" mass="39807" checksum="D3CC886B96509D9F" modified="2018-07-18" version="1" fragment="single">STHAGFAPSIVHLRTPSETSHVAVLLYPLSLSCFAPSSSSTPECRHFLLVLLLRPASLSSPLSHLAWRLQTDTVTRDAGQVGALNTLEFRTYLEQDGKVISPFHDVPLFANQDRTVLNMVVEIPRWSNGKLEISKEEQFNPILQDTKKGKLRYVRNCFPHKGYIWNYGAFPQTWEDPGHQHPETKANGDNDPLDVCEIGEAIGYTGQVKQVKVLGVMALLDEGETDWKVIVIDVNDPLASKLNDIEDVERHMPGLIRATNEWLRVYKIPDGKPENTFAFSGEAKNKKYATEIITECHEAWKNLISGKADKNSIDISNTTNEGTPGYSTSTSSVPADSRQPPAPIDASIDKTFFISGHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Y3</accession>
    <name>A0A2S5B7Y3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Y3"/>
    <dbReference type="STRING" id="741276.A0A2S5B7Y3"/>
    <dbReference type="OrthoDB" id="2528987at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="697" mass="74392" checksum="32A9C368B6676EA3" modified="2018-07-18" version="1">MASVVQAGLGLGGVALPRELRGPSDFVSYHGTPPRRPERPVLPDGTLTGPSDFTSAASPTSSALRATPTKTTRTRSGPAITSDLISYPVVTSRVESVSSVAPDSSAGWSSKSQSMTSYFEHPGTSEVEEAAATTPLKRRPPPIKTTSSSGSSGTSFLSPLRQRFGSMGLSKDKSAKQSSPGLSPTSRDAAIEDIIVQNQHAFDSFRKSAGAEAFNPSLPVPPSWRERPTGPLSHSTLPRSTSATVVDPIRREQNPAMIHRRAISDSPIFASSTFVPMAGAASRISTISSSTRKSSADRLYLSAGDGTDKPEHHFGSIPLTADAGAVINLRSSRRPDELELGWTCMPGIDSNGQPFTMWEIRLRPRPMTRPVSVASRAETARSPRSPDARSLHTYSMQHTPMAPAPVLPPPDDFEPEETPVSPTRPFARSRKASERSEGSSYGSISSETSSSWAGPMERQRGKVSVSSSATSAAEESYSPIDLTAYGVQDDCSPEFSPLRQNVPRSASYAPGVAPFERPRQFSIDLIAEAKTRSMSLSQIKSSRRPSYYVEGYSEDLSMDGTSGPSASRPNRAGTIKSSHRTKPSGILPINVTPDRTSLSSSRPNLPSPLSQRRFDFGAGVTAAKRPEAVADLAGPPLCPLPDLPAVPAERASLDSPSSSFSASLDDSDAEDLGTASIELVQQRRARRLGSRWSDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Y4</accession>
    <name>A0A2S5B7Y4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Y4"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="26"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="464" mass="52092" checksum="15B6933A54DFD04B" modified="2018-07-18" version="1">MPHWTPPVPLCSASQGEKSFAYESTVKRWPVILTGVVDELSKLNGEDAGDSEDDKARLAEGKQLIQDISGLIYEMRHDRVLAPLSPTGLPDDTAIYNDELALLEKKGENKWFSAPWLFAECYLYRRLRGLFAVSKHWAHFDVFASQKLNAWRSSAAGAAALAKTLEKLIADGPTSDQDKLKLDLIGMLEVDLWGNATDLSLLTSLTHEQIQQLQSVERGQHFVLRNDFERAWQHFSKLKDARVDIVLDNSGFELYTDLVLADWLVTLSPFVNEIVFHPKLLPWFVSDVQPHDFGILLDTLADPSFFPSDSGLSEEDRSALTSLVQRWKGYVADGKFRLSVPMDLKMGDKGGELADFWTYPNAFCDLPALAPQLLAELQKSSLVIFKGDLNYRKLVSDAWWPTTASFDEALGPLRGQIDLLSLRTCKADTVVGLPEGTEERVQKEDPKWRVNGKYAVVSFSSRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B810</accession>
    <name>A0A2S5B810_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B810"/>
    <dbReference type="STRING" id="741276.A0A2S5B810"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10919">
        <property type="entry name" value="CE4_CDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF3">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015677271" description="Chitin deacetylase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="55453" checksum="9F743F9CEF7B0169" modified="2018-07-18" version="1">MPPRSRSSRFAASVLSFLAAATVINAQDGGAPTGATSSVESAGYSCDASKCQLPSCHCASPSPPGGLSPQDVPQFITFTADDAIQSYTLEVMNHFLANRSNPNGCPPRMTYFTSLSYTNYSMVTEWYVAGNEIADHTMTHAGKPNTSEIYGNLRALNAFAGIPMSSLTGFRAPLLSWNGSTLQHLHDASFEYDSSMTSATLPNASNTDAYWPYTLDYGIANNCLEQPDICKGQLKLNGLWSIPMYAIFEPNSSTIHLMDPWLDSGNPDTVLEWLKYTFLAHYNGNRQPFGLYSHPIHLATGYPGVTDPIATRNMIQNFLDWVQSFPNVWIVNNQQMLEWIKNPVPNSKISEVQALQCHSPNVPKNEKICNGIPHNEAGLLNACGFKDYPWQTCYYCPAEQPTPDNPVPAPVSGNTRHTLPSDCQTAFFNPQTNKCTCSSSSCSFTDNTKPIGNYSTNLGGADSGSSTGDSKPASAERTAPAKQNSGAVRLTSSAAALSALAAVIGGTAIGSFALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8A5</accession>
    <name>A0A2S5B8A5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8A5"/>
    <dbReference type="STRING" id="741276.A0A2S5B8A5"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="304"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1032" mass="112624" checksum="F86863B6AA492C21" modified="2018-07-18" version="1">MTDREKLPYAAELSGSSSPITRHRRDSTLDKRILVGVFVVALFVLGTTGQSLLRLPARTPIRGEGGRGRFTASGAALSAESETAWRQTVDRCHDLHTLPGPPADFHHRTQSDRYEPETTRPVLIRNATIWTGDLNNATVLYATDILLDRGLIIDIGKDLGVPSVLEGAQVDILDAHGGWVTPGIFDMHSHVGVDALPSLSATDDTNSVAGPIQPQLRTIDAINAHDLAYKRSAAGGVTTSLILPGSANNIGGQAFLIKLRPTKERTIDSLALELPYNVQSTSRRAVADHHQKRRRTDPPRWRHMKHACGENIRNVYSQTRLDLAWNFRQAYDDARSLKRKQDRFCERVLEADKRGAYLVAAGNKGDDEVEEFPDDLSKEALVDVLRGKVKVNTHCYTIEDLNSFIRHTNEFEFPVAAFHHAHETYLVPELLRASWPGNGTKTPAVALFSINGRYKREAWFGSEYAGKVLAEAEIPVTYVSDHPVTDSRYLLYQAQQAHHYGLDADLALASITSTPARVAGMDHRVGSIQRNFDADLVLWTDHPLRLGATPQQVWIDGIAQIVESFPPEPLTEPAPPPQASLPSDYDPQRQPTDDGFDFLLPGDKKHTPTSRLVDRVLFTNISEVILPGYQVIERGKLERPLQAAVENGEIVCLEEQCEQDSEVETVNLQGGALLPPLVTYGSAIGLTDIISEKSTTDANVPDPLLTGQLSPLQRHFADRHAVRAADALAFGGKQLKTADRNGVRVAVTAPLGKGFFRGQSVAFKTGAENVLEDGAIVKEIAALHIQIGHLGSAAPVALEIGELRRLLLLNPEKGIRAATDNAFAKVANGQLPLVIHADKADVLATLVNLKSQVEHETGNKMRWVIHGGSEAYLVAAHLARADIGVVLTRTKSFPATWDSRRALPGPPLTPDTATTILHEAGVQLAFGVRSAFCRRNGNQADPALLMQVEEEWEPSSLLWEAAWAHKLSRGKMSRTDAVKLVSHGVTDVFDIPSDSRAAASANSGSVCSQRDVFEFGARAIAASEGKAVKVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8B3</accession>
    <name>A0A2S5B8B3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8B3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015609864" evidence="2">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="125" mass="12051" checksum="2D3FC05BBB5343AE" modified="2018-07-18" version="1">MEGLAMLCLFSLNPAATMAADDEYDDLYGDLYPAETEAAAPAASTAGDASAAATGSTSDATSSAPAAGGASAYGDAQRAAAGLPSVPVASAMGPGSAISDIGIPRPQALQANALASRTADQLDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8B6</accession>
    <name>A0A2S5B8B6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxide hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8B6"/>
    <dbReference type="STRING" id="741276.A0A2S5B8B6"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24301" checksum="8A88C72221E1E386" modified="2018-07-18" version="1">MHINFMPAVPLPEDAPERRELKPHEERALKKAQAFSETGRGYAIMHETRPGTIGIVVGSSPIALLAWSQSLPFRGSAKDAHADLALRNHSVGEKFLTWTDETPPLDTILAICTMWWIRDSYPSSIWAYPDELQYTMDEFHQDAKYRLDKPFGISSFKEEINMAPKVMAQRNGNLQFFRYHEKGGHFAAIEQPELLAKDLQDCFTQIWCFSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8M2</accession>
    <name>A0A2S5B8M2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000041">
        <property type="protein sequence ID" value="POY73109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8M2"/>
    <dbReference type="STRING" id="741276.A0A2S5B8M2"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="296" mass="33769" checksum="3B96BF0B52D77C6D" modified="2018-07-18" version="1">MTPTAKQLPAWVDQLRNLLNKNMKENKDLISYALATQGPERQPRVRYVVHRGFVNERRKEGDGSQNLVADDDKNDLISDKLVVTTDTRSPKARQLAAAPQIELAWWMAATQHQFRVVGNAYILPSSAFTKHDSSEPRTTGNDGANTSSDKISFPFPEKELSPYDGFNWEDERIRQFRKMSPELRASFYRPVPGTDLQDADLKMEDLPEKLPEGVEEAESEEQKKQVEQGLSLRQDRYLLRSPQLMSYYTAALKNFALIVIDASEVDLVDLGSMPNTRTQWLRKRDAADWEEKGVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8R2</accession>
    <name>A0A2S5B8R2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8R2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="213" mass="22945" checksum="BEE62145E60F5BF9" modified="2018-07-18" version="1">MAILHDNLPPRVWRALPVVAPAACFLLAYPGLRLSYLLYTTACILGVLLNVQVLVETRALYGAVALQASGLGINVFLWPMGTLLHLATDEDDDPTGPKYFWFGLGGLAIVGGLIVWMCQGGGLKKEEVVRWTEREAAEARNRYPPQQPGAAAAPTVPSSDILNADLEAALEANHEAVRTDSLYQPPQRTTSPPAYLDDPDASSVSAPLLRSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B984</accession>
    <name>A0A2S5B984_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_3644</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B984"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="572"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="884"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1380"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="160"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY73309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1569" mass="175385" checksum="00E054E541A163C6" modified="2018-07-18" version="1">MSTARAARERMAALRAARETGQRNYEVKKQEDVYDEVDEDVYRSVVRGRLMEDDFIEEDNGVSGYADHGMDDWDRSGSEKDEDEDLNEAEAKRQREEKKVAKEKRDKQLKAAAKKRAKERLEIAEGANPYINPNRQGSGLPLKEQEDDFMASLLGNLDDQATVKEDTSSRPVAAPVRRSKPTLARSALSASKRAADVDATSFRSTNNFASSSDIASDPVSDPFLAGGPSSDGFDSVKKARFDPDFDEADNDLGGTDPSEFDDFSFSTATDADPLGSSHKANGDVKMEDDDEALFVKPATPAAKPKGPAQRRQLVNASAFKAKSTKVETKEDLVPQSPMTFEDQTPKRKGIDWRTATSALTIASSPLIAAAASDAVDESSAFNENHKTVISTTGMRAPAQQTNALEPDGSLQFWWFDYDEPSPGVVRLVGKVRARGQTVKVMSAAEGKKVEKDVPKYVSATVIVKGLKRKLYVLPKSKSEYYGGEEDGDDSDDEGEELPFDDVEADFMDDANGKWNLKNVSTTRGYVKRRYAFGIKGVPRKETDWLEVSCDFPVGKRNEVDIAVDASGEMYSHVFGSTATPFERFVVDRKIMGPCWLNIKGPNVNKGDAFSWTKFEAEVDHSNVSPFAATDAAAPKDTPRLTILSLSQRTVVHLKENKREIVCAAARVWHDIDVDDPTPIEQQGSMAKVFVRNLFTDFPAGFDQQVRQEKAGPAFALFKSERPLLVQLLDFISRNDPDVIVGHDFTQLDLDVLLNRLRDLKVDNWSRMGRLRVKGDKWPQLRAGRNIGILTGRLILDLSSDGSKSMIDSTTWSLTEMCETHLGIAREDIDPEDTAKFFDNVHSSAKHLQHFVLHCEADCYFQMAIAAKVQALPLTRQLTNLAGNSWNRTLAGNRAERNEYILLHRFNETGYIVPDKISSWEKREQIAKADKSAKKKKRGKTGDEDEEPKVEVKREKFKGGLVFEPEKGLWDRYVLVMDYNSLYPSIIQEFDIDFSTIDWTADDAEDLDKMPDRAPCDGEPQGILPQLIASLVARRRTVKALMKDKSATLARLMQYDITQKALKLTANSMYGCLGYEGSRFYARPLAALTTFKGREILTRTKADAEGLSLNVIYGDTDSVMINTNQTDYAAALKIGEEFKKVINDKYKKLEIDRDAVFERMLLLNKKKYAARKVEDDGSGQPGEITTEIKGLDMKRREFSKLSKDASKDVLDMILSAKATEVVIEEIHEYLADLGEKIRNGLKPLDDYIIHKRLGKNPEDYPDAKSLPHVQVAMKMKAKGQSAKAGDVVPYIFCIPPNGETTKTAQAANAHHPDDVRRQGSTLKIDFEVYLSTQVLPPVERLCEHIEGTEKARLAECLGLDAQRFKSISLDVPEREFKTLQSQISDEQRFADAEPFRIRCKACGAESAFDGISDNKAGMLSEHGFFCCNNECMAPLPLASVAVQLDVQLRRFIGKFYEAWLVCDESTCGNRTRMMSVYGKKCLVAGCRGAMHAEYSDSKLYDQLLYFDTLFDIDRAVAKVAGSAKQDAVHARVDANRPLLEQLRRTVTKHLEKNGRRWVSMESLFSFMKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9C8</accession>
    <name>A0A2S5B9C8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9C8"/>
    <dbReference type="STRING" id="741276.A0A2S5B9C8"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="369"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="785" mass="86513" checksum="66AD607F9847D05B" modified="2018-07-18" version="1">MALAEEPVASTSRLPAHTSAGLPLVTTAAAATSSRLTNEDGSSTQTTTTTPIPTPSILKKPEQTQLPRPYYFYHGEKRVKARIDPEVPLVEVVKQLVQSSQLALGAENALPGLYALRERETKRIVTEENLGEMLARAVHFDLVKSPSVEAQQTARRLASLDPAQLKHATFNLRTSLHDETFRRAFLKADGLPALQAIIRRGSGNTLAYALNSLHVLLDQDGGSLSFDSLFLARIVDIVALETLVNVTRPATAVLCSMTTLARRAPARCIPFLDLVIRQSALFPAVVDRISADDLELADLSIDLLDKLISASVDTSDWRVPDKLEDIDACRAIAKMTEVEDSATATRVAPLGTTFVRYVRAATAAPITEDNYHLFDEIWVASQLEDIDETNRWRRLGFRTEAPQFEFDGVGLLGLKMLKRFAEDSQNEFAKTLHLASVRTSEEEERVPVSTFSNLALRHLLDVFATPLEGASISPYLFRMAECHALAVHFLQRMWEEGGASWSDLERLSRMVKSQINHVLAPELKSWFKVRQEFSAATYTGVRDRQLRELASDHALLAKPKSQALRAQLYAEAYERVSRQRIAALEAGAWFRLVEASPALTGKQAYPRLRESSDPGWRFYRLSPDHATLHWYDADSPAAEKVGLSAMSKNAPVAKIVEVKLPDAAGAHEDGAATNGSEPSSPLLDSTRRRFSVLQRSLPSRPSVDRRPSVGTPFSFALILAGHVPVQIVAPDATTLAEWVDGLSLLQPDGAIVSRATLQYIDTLAEMGTRIKLLDLQDELTDSPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9S1</accession>
    <name>A0A2S5B9S1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="10">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_3460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9S1"/>
    <dbReference type="STRING" id="741276.A0A2S5B9S1"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="132"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="355"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="748"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="758"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY73523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="812" mass="88650" checksum="3B289631B5F63F8A" modified="2018-07-18" version="1">MASSRAGPSRQVLDLSDDDDDDALQDSFNTASSRRNGTPTLDDELASLDEQIRKLKRLQADIRHERDLLAATIASREHQQAPKEAPQAATRLPPASSVDYTKSAFPWTAEIAKTAKDIWGVRKWRPGQEGAINATMAGREVVAILPTGGGKSLIFQIPALLAPGTSVIVTPLISLMADQVHGLRSRGIQAEMIHASTSQAEIKDIMARMLGSAGAKGKAKKNTAEVVKLVYVTPERIEKSKTFTNTLQKMYDAGLLTRFVIDEAHCLSTMGHDYRPSFLALQRLKVLFPETPILAVTATAPQNVVSDMLKTLGLPRKTSQGAAAVPGTTVVFSAPLYRPNLRYQVLPKPSSAQAALDAIVDWILEHHTGDTGIIYTLSRADSENITKGINAHEKAKGKLKAAFCEFAIRILESRVIAELQGTDHAYIDDADKQRVHDHWRDKRIHVVVATNASFGLGIDNPNVRYVVHHSLAKSLANFQQESGRAGRDGAPADCVTFWRAADASRLSSLTYETFHSGGKEKLYEVVRFAEDKKTCRKVLFARYFANAYDSSDAYDVKDADSPCGLCDNCQRDPECVSTVDISEPAYRALRIIEAAIAQRGTLTLPQAADLVRGLGGGTYSTQEAKGKGKGKVDVKTVAGGKVTLSKDETEQMLLQLLVDSYLKEDFHATAYSVTSYLQPASKALRITRLSPDDFASTGLPITLEMDVLVKSNARKKRKASVDDKPEAVARKKAKKAVELEVSSDLDEGVDAFDTTSYGDEDEGADNDEVEAWLELQEPSSEPDADGWSKVKRASHGRPPARPRKEAEVLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9S6</accession>
    <name>A0A2S5B9S6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9S6"/>
    <dbReference type="STRING" id="741276.A0A2S5B9S6"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000145">
        <property type="entry name" value="HAD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000162">
        <property type="entry name" value="HAD-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000023">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF2">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="433" mass="47011" checksum="CB3DFFA4869E77B7" modified="2018-07-18" version="1">MSTEEMSFSPTHPVEHAEFTVEGVLFDMDGTLVDSIKVLEAAWGSVAQELGKDPEEVIAATHGRRAIDNLRDLKPKLRRLTNEQMEEHVEEFEKKILAEADEFNEKVRSRRASDASSRRNSTSSSRRASRRASSSSGRNPLLVGLAGGNFGMSSISKDQSGQESGNASPKSSTDGADLDTVNQKLAKLDTKDDRMAQLDADPFEDSDDEEDSAFDLDEYTEEEIGCRNKSVRILPGVRRLIDSLPTGRWAVATSGAKTYCHGALARAGIKRPKVTITADDPRLTAGKPDPAPFILAAKELGIPVEKCVVFEDSPSGIKAGVASGAKTIAICTSHPVEKINSQGAHYIVPSLDCVHIKRMPGNRLRVIIDAHPPEHPRHGSRGSFVAVPPDWQRMVDDTKAKRRAQVEAAEAAVKAEAERDAQKQSSAATETQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA26</accession>
    <name>A0A2S5BA26_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_3156</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA26"/>
    <dbReference type="STRING" id="741276.A0A2S5BA26"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="661"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="34"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="364"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="554"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="590"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY73622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1262" mass="136480" checksum="C77F43F278BEE097" modified="2018-07-18" version="1">MAPKGKKGGGKRKPADDDDFWQVIPAVVLLANRQKAAKESGNATPLAAGSDAEAEEEDFAPRAPAGGKGKNKRNGGGGGGGFASFADMMVEDGGDDDDNEEPAPAPAAAANGGDESEEDGLLAMAKKAAAKKDKKAKKGKKAQQVGDDDYFDPNADEAAAAPAEEPADLAAPRGAVEVTDDWMEEEFGPTKKKGKAAKGKKGGNKQQQQQQEDDDEVDAVAEKVADVKLDDKPAPAEPTAEGDDGEVKILSKKEKERLKKEKEKAKKKAQAAAKKAEAGPSAPAAATPAATEEAKSTPPAAQEDDAEGDEGGEQGASAKNKKKKKKKAGAAAESAPAEEAPAGKKGKGGGGQIAALRALMEAQQKAREEAQRAEEEERRRIEEEERAIAEEERKKEEARLAKKEKERAKKEQLKREGKLLTPKQKAERAAAEARRQALLSAGNVTIAGLQQEADAPRKVSYGKRERASKKPAAEPKAEEATDKAATSEPAAEKPAAAPTDATPQSKEAKPADEEEEEDVKDSWDASSSEDEAAKADLKDSWDASSDEEDEGKAPAKAAAAPAAKTAEPKPNGKTATKAAPAKGKAAAEVSSEEEDSDDDDDEDDSDSDSDDSDDDSDSDDDSSEDEMTAVERQEAQRRAEAKARREERDRQALAERSTENLRSPICVIMGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPMDAIQKRTRVLGEYDLAEYKLPGLLVIDTPGHESFTNLRQRGSSLCNIAILVVDIMHGLEPQTLESIRLLRDGKTPFIVALNKIDRLYGWKAMKDGGFRQTLAQQERPVQREFENRLNETIVAFAEQGLNAVPYYDNKNFSKYVSLVPTSAHTGEGVPDLLMLLIKLTQERMANNLMYISTLQCTVLEVKVIEGLGTTIDVILINGYLHEGDKIVLSGLNGAITTQVRALLTPQPMKELRIKGQYVHHKQIKAAMGVKIVAPDLEKAIAGSRLLVCTEDDDEDELREEVMSDLTNLLNSVNTSGKGVFVQASTLGSLEALLEFLKSDAVKIPVAGINIGPVYRKDVMRCATMLERAPELAVILCFDVTVDKDAERQADELGVKIFKADIIYHLFDQFLAYKKGIEAKKEQEAAGKAVFPCRLNILACFAQRDPIILGCDIIEGSLRIGTPLCVVKTDPKTKKREVISLGKVTSLEINHKAKEIVKKHEVGAGVAVKIEHAAYESAKQYGRHFDDKDEVISMLSRESIDVLKNVFRKQVSMDEWRMIKALKPLLDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA32</accession>
    <name>A0A2S5BA32_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA32"/>
    <dbReference type="STRING" id="741276.A0A2S5BA32"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="528"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="774"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="265"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1229" mass="140644" checksum="47507149EC6A4B6A" modified="2018-07-18" version="1">MHIKIQGFKSYRDETVVDPFSAGLNLLVGRNGSGKSNFFSAIRFVLSDAYTSLSREERQALLHDSGGAGGGATMSAYVEIEFDNADGRFPTNKPSLLLRRTIGLKKDEYQLDRKSTSKGEVMSLLESAGFSRSNPYYIVPQGRITHLTNQKDADRLLLLKEVAGTKVYEERRAESTKIMDETKPYPPDAKRDKIKDLLEYIQARLDELEEEKEELKEYQTHDRARRSLEYCIYQRELAEVGDLLDKIENERHRDINDANTRREEFNQREKELADIRQRLSVLNETLAALKSEHADLVDERGALTRARTQVDCLVRDAEEASRSTEARRNDVESELERVEAAIEKKEAKLRDEAQPAFQAKKDEQEQAQAELDQLQVTLNGLYARQGRRGQFRTRSERDDHLQKLIDQSDEVLKTRRAREEALVREHEETEKERKEAEAKRAQLRTELDSQKEKARQYADELKRLQNENGDRAEHRKELWKKSSKLDSQAQHAMEQLKSAQRSVSTTMDRETANGLRAARAIAEELGLDGYFGPLYELFEVEDRYKTAVEMTAGTSLFQVVVNNDETATKILDRMVKDKSGRITFMPLNRLRVHDVEYPKTNEAVAMIHKLKFKPEFESAFKQVFGRTVVCQTLEIAGQFTRSHGLNAITLDGDKYDRKGALTGGFHDIRRSRLDAVKSLKAAQLRESEISAERAEVRNASAQVDQEVSTLVGKMKVAEGRLARIRDEQEPLLEATFRAQEDEERLKAKLQRLDRQLVSHRAEMRTLEQECDMWRKESETDFQGGEGLSDEEEEEMRQLSAEADKRKSQLVSLSKEVAELERAKGLLEIELGENLLRRREDLQSRLEKLDAPDSRDDQAAATQDDLAGRKKDLKKIDQQIKHLNERLDEIEQETQTVEKDIADLQKERESRNAQQADDQRGINKQQKNVERYLAKRQVLLHRKDECNQKIRDLGVLPEEAFAATTATTEKLLKKLRKVNEALKAFAHVNKKAFEQYNSFTKQRDELLARQEELDESQNSILELIDVLDARKDEAIERTFKQVAKNFDEVFEKLVPSGRGRLIMLKRQQEKGEDDMDVDEPEEEGSVENYTGVAIRVSFKSKSNEGLRLQQLSGGQKALVALALTYSAPGPQLMPSHVTVFAIQKCDPAPFYLFDEIDANLDADRRTAVAAMISELSEEAQYICTTFRAELIPHADAFFGVVFNQAKISNVKTLTADECSQFIEAAEQVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAB0</accession>
    <name>A0A2S5BAB0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase family 49 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAB0"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF52">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN GNT13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="63225" checksum="249348D0746B3CAF" modified="2018-07-18" version="1">MPDSQGRSNKPPLRSRRLTQLVSAVFALLVAATVARSWSSQPFSTRFRARVDAARARQAALRFPEARAPALKASLHFANGAVQHLFAASKHGAPTFQPIWEPESSLVRVEVPPAGVLGYRTRQASEHTLVVGNASLCETAVGICRGWTGVSFSTSIGAALSYLEAADPSAEALATIPARDTDPRQQSVTLVTQLSVSRLERFDRLLQHWDGPVSATIYLVDESDLAVLADYLRSHSGLLRRVTLTVLKPSYAGDTASLLARLRYPINRLRNLAIQAALSPYVLVIDVDFVPSPNMHSLLVERAVPLIDLADSRKDASPTLKRTAVVIPTFALAKEYDDAGGFPQTMEEVEALYRADPQLAMLTDPNSGHGPTRPNRLFHRRARSPADVDSAPMSNPLINGADSYEVCYEPQWEPYYVLARASHPLYDERFTDQGGDKQSHALVLNVLGFRFVVMRDTWVVHPPKRDAESEAWPAARLERALSELEEREAEQDPSYSSARSGTDAPTTPTEDDHFNLAAQRDDSRFRYFQDFLPEMERLWGAATARWPRGCSAELLAQERMFGRARPASAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAB9</accession>
    <name>A0A2S5BAB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAB9"/>
    <dbReference type="OrthoDB" id="10324749at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="91" mass="9314" checksum="1E2F3C46F9CF53D5" modified="2018-07-18" version="1">MQRSQAARPPFNAATAGEALQQAFQNELEAVRRAGNGQGPKPELYAAKQAPAGPWGKPAAGKPASKAGAMANGQDFLGALQASLDKIKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAI3</accession>
    <name>A0A2S5BAI3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pterin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_3331</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAI3"/>
    <dbReference type="STRING" id="741276.A0A2S5BAI3"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="16">
        <location>
            <begin position="605"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY73790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="904" mass="99473" checksum="4404924644881457" modified="2018-07-18" version="1">MSDVISVTELHLRSSRLEPDLWQRPHKLQPVVVSLQVYTNIDNEAHCDNLLAGSLNYGAITKQLELEFDQLERANESDDQLGLEIVAELLAHAVLFKCHAPNVTLQVERPRALLTASAVGLSITRAKSDYLAVEPHRLDLALAADNLAADTFYIRQLRRQIIIGLNPGERIDQQEVIVDLEFKHGPIDLSCADMHYLLPREVVRPGWQGWRGAVKRVEQHLSTSAPLTIEHLVVALSSLLLTPEPMRTVLDSSQDVTSEPAWSVPETTVRVSKPSALMFAKFPAVQVTRTRSHFPHLFGQAAPPPKVVPTQYQQRRDLSSSAIVRPVTARTASAFRAQVTDQAPFSTSTSTRTADHEQQPQQPLIRTAFIGLGTNLGSRPGNLNDAVTLLDEALRKEDGGRGRVVETSWMYESEAMYHEEQDKFLNAAIKIETSLEPVRLLDVLKDIESRLGRDFSTFRNGPRVIDLDLLLYDQVVYDSSEQQGSEENGGEGKKKRWLKVPHASIREREFVLRPLVDIAPDFVHPVYEKPISALLKDLTGSASFRSTVHRVFPLSQARVHPYSRADPSRGLRTTTGKWAKGSNNLEHLGVAAAPSSAVADGDRKTLIMSILNMTPDSFSDGKLERLSDVQVALREVEEHLEAGADIVDVGGMSTRPGAEDVQPRDEVERVVPIIEAIRARFDQLRSGGGKAPNGTTSAATSELHEAPLVISIDTFRPDVARAAIRAGADLINDVYGSREPGMLETMADLACPVVLMHSRGNPSTMTSLTDYSADGGVVAGVRREMEEMVRRAGEAGVRRWNVILDPGFGFAKTGSQNLVLLRSLDNLFRASPTLSGFPVLIGLSRKKFLAADKKVARDRRFETVAAVACAAQSGWCEIARVHDTADARDALTFTDRLVASKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAJ3</accession>
    <name>A0A2S5BAJ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAJ3"/>
    <dbReference type="OrthoDB" id="4658133at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015759991" evidence="1">
        <location>
            <begin position="21"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="280" mass="30015" checksum="A3B9BE471818D85E" modified="2018-07-18" version="1">MLAFLPLLLATCSLPLFATAAPAQHLEARGSSCHNNEEVLVRSGTSFICLGNKVYWRGAAISAIGATTVSNVASVMTNWVSSHAVGAWDTQSGRKRRSVGGVDSDTNTTVLTVGAQSTVVPYETVGDRIVIDISAFLNAGSSLGKRDDADEVAPLVGGSASYFLDGTLDTCTLDWAISETTYAEPTESDSPSTTVSTETLAKRSYWTLHTTYWAAYSHETTKLNWNEIYSIATASYRSLPNGVSQVCGYMANSGTWHGAFRHWTGDNGQQVGECSPERVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAL2</accession>
    <name>A0A2S5BAL2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAL2"/>
    <dbReference type="STRING" id="741276.A0A2S5BAL2"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="226"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="485" mass="53510" checksum="DF3AE69CC45528E1" modified="2018-07-18" version="1">MADDPQLRVPVLTGPLLPLLPPKPLSRQLPALPTRGSDAAIAAGWTCESLVIPAAYPRSFRHATKKPDEPSPDPTRGSTPKPDLTKGFGRLLETAVDSYTRPVRLEDEDELERQQQLIIVGNRYRPPASRRVAARDAGPGLTLVLSHANGFYKGETARTDLVRARPFTEVWEPMLADLLAELEQRQAHPVEEIWSLDCALQGDAAVLNEDVIGSTYNWAENGRDLLNFIAYHLDSQDDQVPQLRAADVPPDVGHLDKVSTIDPGPADPMKRTYRQRLIVGIGHSLGGSATAFAATACPSFFSSLILIDPVLAPPHSSSPERTAAVAMGALRRRGVWKSREEARRQFKAKPFFQSWDPRILEGYVQHGLTETAEGSVELKARPFYEAVTFMDVLSSASRRATTRLSSLTRNLPLHYIFAEEGRSMLPEPATTYLVSEATPHATWTRVRGAGHLVSLEKPRETAVCVADFLEKTYPAQRTRPTEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAY0</accession>
    <name>A0A2S5BAY0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAY0"/>
    <dbReference type="STRING" id="741276.A0A2S5BAY0"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="303" mass="31703" checksum="52EA2752A02FAE96" modified="2018-07-18" version="1">MSGKPDLIALNAASMYDLTGLVAVVTGGASGIGLMISSVLLANHATVYIVDLDEKLVKGIAERYSDLAQESGSRGKMVGLQGDCSSRDAAEKIAAALAQHEDYVTVLFNNAGIMGGAAEPPKQLSGDAFKKSYSSLTDEDFHNLGPYFLSSAFLPLLVVSKSKAPYGDKFEPQIINTVSMNGWTKDPATGGHNYPYLLSKGATGHMTSLLAHDFLKIGVRVNAISPGWFVTGMSAPGTVNEYGISSKQGTMESDDFGFKTPAGGSGQAKDVGSAALALVVNRFINGESILVDGGTLLVHPSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBC2</accession>
    <name>A0A2S5BBC2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBC2"/>
    <dbReference type="STRING" id="741276.A0A2S5BBC2"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="3">
        <location>
            <begin position="481"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="4">
        <location>
            <begin position="706"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="732"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1021" mass="111018" checksum="345ECCAADB94F45B" modified="2018-07-18" version="1">MSGYGYPPAGSSNGRGGYQGDYGNGGGGYNGGYGSPQGGRGGYGGGRGGSGRKRARDDDQHGQNFRRRYSERGDYHGSPRRGGYGGGGGRGDAAPYDRVPSHEAMKTRFKEELWTLGNDSSYDPAIDIPSMAQSIESWYFRDQSLVFVAFRSAISEMPHKLPHYAALLARLSLNAIAAPVSLASRIGGGGGGGGASKFTPAAGQSPPRAANSSGGADGTEANAGLEGEDAKPAQPEPEKVNVGHAIVQDLAKAFQAFLDERKWKSVRYCVTLFATLTTLPSTTPVVSLSSLITLLTSFVSVLDEPGLRAARGDECVRIVLEALLRLDPASLNEPGIETLREGVHAYMSSRRIEKELFADGENQGQWLDPLEHLVSAFSSIGSSDASDSTPVSDVIPNVYSALTLAPAEEDEAKSQVIEALMLPMVLVPPESDEGDLTLGAGAAIERAIPAPPITAGLRGDEGIGYDGVRLLLRLFDDETVPAVDEPAGVVVRSMVHDIISLYEVNRKDGATLLLELPRWFKKGTFRDPKAPKRPVDGDEDMPEEPEPLGPQWSLETIVVETLIVLILALPAPPHTLVYYYSVLTELCRISPTTVAPSLGKSVRKLYAALGASGGEESAGAPVLDAEGVRRFADWFAVHLSNYGFMWGWNDWAPDMDQSEKHPKCVFVKRVMDLEIRLSYFDRIKNTVPGSMLEAGVFPDEAPGPDYTYEDPEHAHNAAASSFLRTIRSKAPISETEDELSAFQKSLESENNMTTEEAERVKRDLAVQTVLFVGSRSFSHFLNALERYLTLLRNLTTSPSARQELLTTVAVFWKRHPQFHLIVLDKLLQYRLVDTRDVISWVFALADDQPGTRAKTWSDPDLWVMLQVTLRSVQKNVDGAKMRVEGLGREAELVGAEEDNRAGGEGVVDAEGDVAVRDADAPENPELAMAKSYLQEAEDEQASTLIEVLGYFAKLLPSDVSRNDWETWWLEGWVRELCRSSFDRKSITSQVIVDGIAKLDLENVSPSVASLVEAAKAWHDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBU5</accession>
    <name>A0A2S5BBU5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBU5"/>
    <dbReference type="STRING" id="741276.A0A2S5BBU5"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="110"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="564" mass="61252" checksum="FAB5B82065D1E8FC" modified="2018-07-18" version="1">MTARQAESAAPSATPTAVSRASSPTRSHSSHSAQTLADRDVQDLEKGDLRKQLKTNDGGNGGGAASDAGDAHDDEEQGSGGEKQQEKKKGDGEKDPFHVTPEGRMHLHPHTWNVAYRWFITGFAGLLVLNATFASSAPSNLIPSIIMHYGVSQEVGVLLIAIFVAGYCIGPLLWGPLSERYGRRLIFLGVWPFYIGFQIGCALSPNIGSLIVFRFLGGCFAAAPLTNSGGVIADLWGPERRGDAMAIFALMPFAGPALAPICSGFMQVSGVSFRWIFWVLTAFAGACGIGIIFLLPETYLPVIMAVEAKRLRKETGDDRWHADLDKKQATGIKAVLERTVLKPFIMFFQEPMLAVITIYMSLVYGVVYLLFEAIPIVFEETHGLNAGLSGCVFLALLSGGFAGVIGYLFYWNPKYTKEMHKRAPKMVPPEERLKPLLIAAPLLAVAFFWFGWTGQYKSVSIWAPILAVFVLGFCVLYVFLTGFNYIIDCYLWNAASALSINTVIRSAFGAGFPLFATQMYKTLGTGGASSLLGGLAILFIPVPFVLIKYGKRIRGLSKNAVVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBU7</accession>
    <name>A0A2S5BBU7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myosin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBU7"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Myosin-binding" evidence="7">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="611"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="825"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="925"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="935"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1022"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1105"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1122" mass="117559" checksum="16FEE5E12BBF8157" modified="2018-07-18" version="1">MAESYADEGEPLRDYLDNVNETERSVARPEPPKPVAVRPPLLATRSSSSSTTSRVSPQQPQHYIAASERIKYALATSALLSANLRDALQLYPPLDQVAAAHDDKGSACAATRVDKGKAKAGTVTPREPTTEWPQGWETAGLGFRDRSVVGNAAAALSALTRSLSLFPLANGTASFDNATPASAATADAADAIKPIRIARPAQDAAILAVQRFITGAQELDLRVAAALSAIKELECIAHGLGLSDPLPPISRIEARSYAHLLAPSSPLPSTSTSPASPSGGGSPPAAGAPPPLRALPLRRALASALQETLAVLERSTADLNALLPRDSPLLSLVPVTNAASASKGNGRASKGHEASKASIAELLRHDERAQEERDELERFNEGGDEAGAGASPTSSTTSAAIDAARTGDASTSVPPDPFHPTDSTFGGIERRQKSSLASGGGTPHRLRESLSATSASQAASSPLRRQHSSRESTSSNATFFGVDEDVGGAATTPSRKGSLRRKRPLSLGGLNASTNMRRSVSAGATASSPSGSSPPRADPASESPVPLLLVSLQDAFDDVHALRRGVIWRLLEALSAAESDRAWNALSGLVGSLGRRIEDVAKEVRDAHELEFAGGPKGRSLSTRASQKRRTSSATSLSAPGDTSFDLEKEKRRRSGAFARDLLDADEDGDDTPRLQPAAPQTLANRRDALGRLTTTAIGVGSPSRTSLSSRRAPTSYADFAPSTSVSLLGRSTSRQSASTNGDSELATHARAMVLALRAVEAKLKFVVDDVETGMSHPVSPMLEERKRAAVETYDGIGQELRRVEEQWRAGARVLKEALGLVEPAADGEEPMDAATASDSLAPMAPPPALTSDVDNDQPEAPLGAEDAILQAGMTGEEGEDDPIKNRQALVDAALSLSLLPPPVSDPSPDSQHEETRATALEEKVFEAVAGPSRSESDGSKISREERIRRMKEAREALARGRESLGNSPVKSRDGTAAAEGGGAAAQQKMVGELQDVLREYNRERGRNVDSSPTVTISPVRSRPPPPPAPAFVFPPPVPFVPVPRPQMASPPPNARPLPPPPPASAPSPPIMVSPRKALPQTPPRNATSPVSGLRSRPTPPPVQSPLSPRSSPSKRPSVQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBZ6</accession>
    <name>A0A2S5BBZ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBZ6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="256" mass="28062" checksum="05544558BD626640" modified="2018-07-18" version="1">MGADVEELEEDDEEDDEEEDDSDHDRKPVISDSADEDTDEHSDDDSDPEPAKDELVKSASRQSPAGATSVPRRPAQQRHDGTEELLRPQDADGWMPLAPRAGVGAEQAPATSSLPHPSQDGGGDPSLGRHPSSSSEDSESKAEGAAARPHSVCSQVRERTRAGDHLDCDPYVRERRLAVPTDKSPEVKAAYERFGHELILMFETTRRKSRADDCSRLSWLMCRTLENRLESAGQELASLKDAYENAIDSKAGIRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCH6</accession>
    <name>A0A2S5BCH6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCH6"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="534" mass="59141" checksum="1709D8C57F65D978" modified="2018-07-18" version="1">MLSIALRTALRPRLGYAARELAAQQPIRSFRHSGPQPSVSDWLPKRMRKGFSRTPTSLLQLPRREQFDVKLSDVEFYSLSAFEQIRFAMNRPVPIRAPEVTDKRLRHILTRTPFVMILPTKEDREYQIAYHHEHSNRIAYATAAEVLFALAPLEEKKPQGKPPLGVLSSELDRLVTNEMHANFSREFGLAARITSFNGAKSEADGWEAYLSALQISNGRRCLLEFYAPLIRREYLAKQFMRSFDRLPPVITASTTSLQALGVKEDDVAPAPPLIFAKSYPKASDSKLATKSDKKVVAATASSALPQKTIAEQIQAAPNLAPNPKKLSKMKKPNYPVEVPQSADFLPALDEKGIPFLLAFHSGTLMLTLPGHAPFVVSVKKKLQRQNLASQQLVEKVRAAGMLKILARGAPLVGPSRPAADARATVAPDTSTSKAGAPGQQPPSLLEMAIKHGFEPLSFPTAEAARVGFQKALQAQGIRHSVHARKRLEALVIPGYKIRVSVTPRRPKKGEELEDYRFESLVKACLNIGYFQLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCJ5</accession>
    <name>A0A2S5BCJ5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCJ5"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="73"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="374" mass="40631" checksum="DB8F531426939711" modified="2018-07-18" version="1">MSKHEQQPSQSFTFQTFFQEAQNDVPFHQKPEPNVGAMRVERSDDAQGVTGGSKRSDEVAGEQPAWRKLPAWVYIVAWIATSSAVILQNKYILSDLGFRHPVALTTIHLAFQTIATRILRRYTGMVDKAKELEATGVMNRDAFLRKIVPVGILFSGSLVLSNWVYLRLSVSFSASLPAFTPVSVLLVSAAFGLKELTRKILLIVTLISFGVALASYGEIDFELVGFLVQALAICIESCRLVLVQRLLQGFGLDPIASLYYMAPVCLAINAVILLPVEGFGVFSDAVELVGIPYLFFKCVLARDLLLTASLTFALNLASVSLIGKASGLVLTLAGVLKDILLIAGSWGLLGSTITGLQMVGYAVALVGLVWFKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCP5</accession>
    <name>A0A2S5BCP5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCP5"/>
    <dbReference type="STRING" id="741276.A0A2S5BCP5"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="450"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="745" mass="85120" checksum="0D1723415FC65CC6" modified="2018-07-18" version="1">MSHVRRRSSSRVGHAPAIVQPAYLDVPPSPFIGRTPKITSPAAAQTSGVGVGAKPGGPGWLNSSRSPRASGPDRSPLLSKRTNATGQMPTLREAVTRFLTIILRLLRTPKGMIIAATTLLLCWTSAYVRSHSDELAARTVHPSLIPLIRHSGNMVHLVSPKLGARIKGWHDYQVENDPTRPPTREELERDSKHTFHPNGLLLVNPKGRHPIHVLIERAERRWKEKLERQSRTLSEAVREYKQRYRRNPPKGFDDWSVGTGQWRFCEENNVQLRDEYDQIAHDLAPHWALEGHDSRHRNKVMQERDHTFTIAMQPGEPHPTIHGPYAHIKRASDIADMLALFTGRMPRPLNITYIIDDNPAVMLPYTQRERMVELGQQGECPSFSLPQLDWGNHPRSDYGPSEFIDGEDPSLSNFAQACAPNSPLRRSERGEHYTDYSGENVRSFVWNHAKVMDLCQHPEARKLHGHTMQQGVPLGPLVPLFAFAKTRLHADILAVPIEQWEAHYVGYEPSWEGKSMNKLLWRGSTTGVEFNRHTPWRRSQRARLHIMSHETAGTKNLMWSRRGQLREANVSIAAINDLYMDTSFSGALQQCDPETCKLLETKFDMKPTIGQDESNTYKYMIDVDGNGWSGRFHRLMSTRSVVLKSTAFPEWYQDRIQEWVHYVPVKIDYSDVYDIMAFFVGNTNGQGSHDSLAQKIGEAGRQWAKEFWRYSDMAAYMYRLSLEYSRILHHDQGDVDYVEMPSFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD65</accession>
    <name>A0A2S5BD65_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD65"/>
    <dbReference type="STRING" id="741276.A0A2S5BD65"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="483"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="635" mass="70691" checksum="D9C24DADEA00A465" modified="2018-07-18" version="1">MASTRPGNANFGQTPLEDRGQDEWERDDPLWRDRASEDEEALNEGRDERDSLYATLNLERDATDEDIQKAYRRLAALLHPDRHRDPALKPAADARFAQLQRAYETLSDPAKRAIYDEFGEAGLKTQWELSTKGKTPAELRAEFERLNRQQLEQNVENLVKSKGELTVLSDARVLFLSDSELERLGGPDKLGLVQRLQTVQQRQIFLKHNFTTPISPSTAIVATTQVLARQGQGAGNLLLKLQHNPSSKLSLEIGTTVLRPRALTFKTTYAPSSDTFTRVEVPFRSLSQPPKFTCTLGRLIYPNTTGTITFRSGAWALGPWGSDLLQPYSDSSLSVGLSHTSGWGLEATNTVFVKQVAISYGRTVLGGVRLELAGVVTNVGATSVSISADRRVTENIKAGMGVEVAASGAMTVKLRRVDSCLPCSIFRELILAEKSSFNRLGQRINLPILIASGFDARLFAGFTLLPAVGIIAANHFVLEPRKRKRVSSKIRELRKEHAEWIRERRKEALDAQALLAEAAKKRVREEEAKSGLVIEEAVWGVLESMQDKVTDDASVRWLDVTVPLQALLPTNLSQLTIPSGRSKSSLLGFYDPAIGEKKRLRIRYRFRGKLHEATWEGSEAVALPMRSHMCEDEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDJ1</accession>
    <name>A0A2S5BDJ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDJ1"/>
    <dbReference type="OrthoDB" id="3353982at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="71808" checksum="30E6D2181AC59438" modified="2018-07-18" version="1">MALRLPAELWDHVLLQLDPDELQHTTLALSRALGNRVSISRAVWWRHLAVTRQGQAWQCIQQLRNEPQGTRVESLTVQLWREDQQLLVNLALAPPLESVRALSLTVGPLAAPEHVQDLLDPVALRRNPNRFRKLEQLAFRFNPYCQERSYYTFLKGAYFDVAPLALAAIGTSEMPQLRRLSFIQDLPPTHGSVKKETPAFGLRPQQQLEDGMAGLDLQGAGGGSNGGNEDGAESDPEPAPVQIAGKYVGKRRKGDKMDFAQPIVFFQTACLTRLALSPVGAQLEHLSFRLPRRNVLTALTDLPPTPGFTLSRPFSRLRHLDLSTTYITDDLRVPLTLRLYYSLETLVLDRCEGLVSRDAVEEPTALATLRWLGKCCGAIGLSRADDVVRTWRRIVKDRPSDAPTLPPGSTADAIPPVRDLLVLPPPCSLRSLGLGLHDRLPARVVKKWERAFRDGYEEAVDRAEERAEDVRDRWERWARTGKLQEATRRVVVFRDALEQIDLPPAAEHAASAASDADLSAVDPDPLFARFCVARGLEPLSPLAVPSQVSSLVLAHTAAYQERFSTFTLCLVPDCSNRPGVPHLALNPAGGGGREDPEERQAKEKRAWEQERRDQDSSRADAWRRPASEHKGHCAHVEGREAWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDU1</accession>
    <name>A0A2S5BDU1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDU1"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="126" mass="14207" checksum="D83DBB8B935B831D" modified="2018-07-18" version="1">MADLRSDHPHNLVESLRSFEIGSNIELSAENNLADLIETLRYMPNLDRLVLTCLAVGSRGVLPDSDRIRIDSKPNDLTLAIAYPHLAILVRYLESTAVTTFCVGADEGMARWLREDPLEPFERQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDV5</accession>
    <name>A0A2S5BDV5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDV5"/>
    <dbReference type="OrthoDB" id="10668705at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40864" checksum="C33030857034E428" modified="2018-07-18" version="1">MTRCRLPLELELHILELALPPLRMTAVKGRVDFCLAVSLVHRSLTAWAQQHLHEQFLFVYKNRDGELQRLEQRKRDATAAEEGWQPTYILLDLQDLDQDLGLETCHFCSARFFDEDSSDAEEHRLNDQFADWDPGCDVVYLGGQVHTWLKQTPRLGIRLPHSMLNLSGTLGRRLLELDSGACLECWYDPMGLTELCGGKIVLSNYTVNRWFPPCHTLRTLVLASSECILDNLGDFARAVPNLHDFVSHLSMPNFSSDVLKYLPADLRRAFFISYDDFDLEDDNKMRHLTFRKPAKLELCSLVKLRSPSRSLPASEMANFETLCAPLVAAFTEEGAEFRYKLSSRPAEEELADVMGALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDX6</accession>
    <name>A0A2S5BDX6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDX6"/>
    <dbReference type="OrthoDB" id="2521209at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="447" mass="50900" checksum="3829CF32B3D55867" modified="2018-07-18" version="1">MAPNKEDCSEPPHGKPERTNSHPNGTKPHGCQHGVDRPKSRGSGQSPALRLPTEILLRVFEFLPILFAHEIREDLVAWSVTSSCPNLMNLSLVCRGWRQAAQGILYHSITLARSEQVELFLRTIRERPDLADRVTSAQLGLIDGTPEWSWSTEKQGNLSDQFLEVISRLGNLRNLLLRALTQGKRRDIHELISRLPLECLMLKFYDTHLDLQGSRLLFSPADIYRTVSKPKLQVFELNWRPHWDDNTDYEIPSDLEPALRRLSVTVNSPPGLIHLMRLLAPSLRDFNLYTEHALEPEATGEAMASLVHLHELRFHSQISTSVGAGETNGWFCNYLPALKKLKRLSVSDQVAQPSILKRLPASLDVLEYIYWDRRPDAMIGVFEEILEESQQPLPLKEFFVAVDEAAYNEAVDEDLVQQVTYSFAKRGVKFQVTFELADIPRIGWCQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE36</accession>
    <name>A0A2S5BE36_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE36"/>
    <dbReference type="STRING" id="741276.A0A2S5BE36"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="856" mass="93878" checksum="83F2EB170F3F358F" modified="2018-07-18" version="1">MKLPDPLKLVALLGAADTRSQALTIVDSEGPARSSETLRALLPYLSLPTLLSLRTSRADLGQAITETLYDLIDAQRDWVVSPECPAELRDAYLVRVFGKEWPEAKAGMEEVASGELERVKERLVLDATKVGQDDKAHPCAGLDEFRDKLKKATGGLLEQVDWNNVVLGGGAVLSILTGKGDTPAYASSDIDLFLVGLAPDQVIPKVRSLIQQIKAALPPRPKPTVTKYSGSFLKGDQRSEEVEVDETDPEWRAEHAFDWDEQYPGELLLIKGFNAFTLVPPDNVSPRRTIQIVATINQSVFDALAWFDLDCCAVGYTGDSVVAVPRAVRSLSLGKWTGGVNFFDPKLGRKGDPTGSTASSRSCKYLQRGFSLALPAAALNALGDVGLNFSEVIAAGQKEAAEQQQPRTEPDLSLRRTDELAGLAGLLRREAIVQRKLKSAKNAGAGKPVEADDNGDVKLDYGYRNAFWIKTVSEALLKYSGNGTIAHEFREYAAKDVATAMENLLIDVDKAASGQSKKLPGAPRENARGMDHPVGLDRPYADYVVPYAAGFDVDFALGYKTVADDPFQQKWTQIRDLQYFIKLPTKLLPLMEKTEKTMRDVIAGKTVAQLTGDAAKSLPAVSEALREPITQLFAKSLLSVAPGLTAQNAAIDRFVPDSFPGAYRCAAPSSRHFAQKKAPAGHGIKSLLSPLSSVDGREFKPSKDKNQVYRVVTLAGLWQFKGVTPEIDVALQIIWQAWTATVRAAMTLPRDLPFMQMSNMSLKSFSLEDARRDLLDPKSSIARIVRGMKQSDRDSAIKWLEQSTTKEVFDTLNHELEQIDKIVKAEMKSPEGQAVGEWDVDRKRFLHQWLAGKEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEN4</accession>
    <name>A0A2S5BEN4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEN4"/>
    <dbReference type="STRING" id="741276.A0A2S5BEN4"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="4">
        <location>
            <begin position="894"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="622"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="661"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="732"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="860"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="990" mass="107255" checksum="3804610A42C1B0E5" modified="2018-07-18" version="1">MAAFHVRQPSVDDTPTRPSSAAASFSSNLTSLKPPRTQSHQQKPSLSGMTSRAGAGLAAIDLNRLDARGNHPRPNSRASATAVSSLKASDLDGLLDNDPHNVGPIEADNTELARRRAEASFQREMEDLRNAALSPSSASDVSLGRKQPSAAGRGARSRQFDDETASSHSRTSASSYESLRIGLAGTAPLASVHGAGSGHRQGDHVDGDDDDDLTYVTLPRSEMTSPAQTATPGRPVPAPAATQSASNPLNRSALPPTTNLFASPRPFVASAGATLSAARPAFSPAPGPVTAQRAQGQQPTFSSSPRPRPGTGDENAAPSRASPQPQAAKPAGHHSQPSLPSRASPFSGANPPLSSFRSTGTPQTAPPHRPSPLGRNSPILAASPSATSTPAHSRSFTSRHTSAPGFADRTTMTALPDRTGITDFLRSPERERQILDRERRAAGESSNRMSPPQPLGHSSAKTSESNLAAQALAGLTAKLATLERDNIASAARVAELEARLAASRGAEHNHNQSRQQEEEARRVRREVEILLGDERARREDLERVVSSLRAQNAHLDATLSAQKQTLDALRVSRSAAPAAAPTATHEPYALKSEVQDLKHALAALGYEVDGVRTVVEELLREKEERDANKKWEAEEAERRADLQAHREGQVPFASDGSVGTPDDHVEHRHADESVRSWVSREEVEMLKREQREEEERRKRSGAAPYPSKAGAARPRQAQPEVSFAASQDPTYAPSAAASSVEASDASFVSVTSATTDSLSSASTVDEPDFARAERIFASAPAAHRERRRTRRSSADGADKRRVDRVVLLEEPSANLCTNCHGRKDSLRRGSGTRPSADKGTRYRARDDGAEADEEDLAPVDEARERRKREHKAEKARREKAHVEREARKEAERKAREREEHRRTLEDVLDRLEEEFSVQKKIYLELTAEYQSMGSRSQTSKRRALASHLKKSIDVLEDKARDVKRYADALENMYEAVHDKTCPQRSLHAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEP0</accession>
    <name>A0A2S5BEP0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEP0"/>
    <dbReference type="STRING" id="741276.A0A2S5BEP0"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="237"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="483"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="649" mass="68573" checksum="5377377C6B6191FC" modified="2018-07-18" version="1">MLVRSGAHTRTVTARTRAGTVRSLGWFSRSTLATSTSATESPAPPFDDATPVEDHDVVVVGGGPAGLALTAALVQGRAPVGPLLLADTVDRLPIAASDAIAETHSITLIEGGSLDQTRNWALPESEYSNRVSSITADNKHWLTQTGIWRHLDEARTWPLSELQVWDGLSNARIEFQSPIVSAASGSSPAAATATAGDDWDAAFAAAMRPRRAEMSTMVENLNLQRAALRRIDECARDPGRRVELLDQTRVEGIERGLGGWPVLNLKSKSGRERRLRARLLIGADGANSPVKAYSRIDTFGWAYDRHGVVATLAVDPMTPGEGMNTGWQRFLPEGPIAFLPVSDKHASLVWSTTPTYAALIKSLPLEVLAPLITCAFTIPYDQLKQSLESLLPSPGSDVRPSMSAPALVAQLQELLVAHSRATYDPANPAPPLPPSVVSVQPSSVASFPLRLSHTSSYLGLPTPPPLSAEAVPAGAVAIAQDLRTVLVGDAAHTVHPLAGQGLNLGLADSRALSTLLSRLATQGADLGAFLSLKPYPKERYVANHAVLSACDHLASLYGRTDPVSVWARSTGVEVLNELGPIKEMIMRRAGSAKGSGPTPPAGERGAGVWGAVASVFERAGQVKDVASLVGRAAVGQVGARLSRFIVQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEU5</accession>
    <name>A0A2S5BEU5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEU5"/>
    <dbReference type="STRING" id="741276.A0A2S5BEU5"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="988" mass="107167" checksum="21982B7019531D53" modified="2018-07-18" version="1">MAADGAAPAAIVVKADVHGFQSHCRRITFADRSQLDNDVLHRKLATAFALQPGSFRLAYRDDDNDLIALATPADLLESLEYFSFGSSNASTSTSSQQKKAGTITMRLKILVDYDGPALSEAGTGLGSGPGGGGFSSVAPSRTGPLSVISHAETTISVAETDREGALARWKAEQDALAFQFSRVAVRDPPPGVDREEVRHFAAQEREYQRSRRNFERDERQRIQRRHRERNLEAMERNRERRILNELRHMNSGPTTPNATVPFLSTLHDGSSGDEWIRERAFDKSHGGLPDVDAASDRTTSSAAGRSLADGQAGPVELDAAGVSDDDDWDRETVSSFLPFRGDAARQLAIHNGGPSDAHPLVGYGRAGRMDVRELDHLHPNFASHFIATEHEIEQYLAPGVATPDGTGYPVEPGPSNGSGRLPFRSYYPHQRPQPSYPGFSPMFSSPPGSSTYSYAPDSQYGAIDGESIYRPTGSERARVDALFAPSEYASTSNGISTDAGVPNIASTADEERRAEALDATSVWSEELERSSENAQRRSSGTEDGRGTPGATDSATATTTATSNATLIQGDSASEDLSCAVCSDAITGIRYMCIQCDGYNMCEVCENDPGTKIAERKKRSASLSSRMWNRHANEYIPMLHDSNHVLLKIRPGATVPPTLALLAGRPAHAGPATPPVPIPPPPPPVSAPSTPLPFLGRTKHIPIRTPGDGPTRLTRPNREVDAPQQAPLVPGFTIPAISIPSVGVDIPAVNVPPVHVPAVHIPPVHLPPIQLGPPAPTPTISALHSRSADGSALLPYAVQPPSFRRFDSILERNHGVNCSHCGELIPTGHGEAGCHKCERDSARIHDPTHAFLRLTHRLQRPLPSLRSGLVPLLYLPLTPDSTTGSDNTQYEKTDGTESMVMQRPDRDRVVCDACGKLILEEWMMCCHCPVSFDLCRTCLVDRDASDLARHNPSHVFLQLKEKVDLELLKQVTRFTSRRPRGLIEWDLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEW4</accession>
    <name>A0A2S5BEW4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEW4"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034595">
        <property type="entry name" value="NDUFAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7560" checksum="3C7E2034A2B640AD" modified="2018-07-18" version="1">MLQKPTRQAYKPLSVLPKAAAQCAEAGRAYGKCIGARYMDVERGMCEREFVQFRQCMVEAMKKARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF02</accession>
    <name>A0A2S5BF02_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF02"/>
    <dbReference type="STRING" id="741276.A0A2S5BF02"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="60564" checksum="A8CD771DDD62809A" modified="2018-07-18" version="1">MAPKQKLPKRVLVVGAGAAGMSCAEQLSLGPDKFDVTLIEAQDYCGGQAFSIDIDEKQFGASWMNQGVQGGSYIYHHTFHMFKERGTKAEPVELEVSFGKGEHFWTNAFPTQLLEKHAKEIKRFKWAIKFMRWFELIFALIPIKVTLKMFRFSDEFMNFMIYPALALFLGTGNATPDLPSIMMERLYTSPTYGMWYPIDDKALSSNLPPMVVFPNETEFYTEWQHQLESRGVKVRLNTEVTSILERSKKGVRLTTRARRPQPDHHNPNGADQDLPEREEEYDELVLCVLADTAKELLGKKARWIEKKILGVPKWSDDVTVTHNDTEYMRKWYEVDFKPELAVSKLGDRDESERYERGKKSFAPMYLIKNNPGDPAKLEMCFDCSNFQFQLKEQERPFEDHAFQTIFLNKKHQHLWSKDEIRKDKIIREDWWHQLCHGWTHYAGCVPWMWLLQGKKRTRYAAAWTLVNAHEVAVISGMAAAYSLGASYPEELEKDSFALLCFRLYLLLEHFTWYKKGSNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFA9</accession>
    <name>A0A2S5BFA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFA9"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF1">
        <property type="entry name" value="URIDINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="556" mass="60380" checksum="122454453B374365" modified="2018-07-18" version="1">MTGLLARLEAPAHAGSNRALDNADLRATPPSRRTWGFFFFASFWFAAVSNVSNWVGGSTWLALGITFWEGVGCATAGYAIISLWMIACGRPGARYNIGYPVVCRTSFGIFGAGWPALNRAVMATVWQGVNATSGAQALYVMLYSMFPSIGNIKNKMPAGSALTSAQMICFFVFLVINGLMLLLDIPKWKRLVWSKVVVFSLSAAGMLALAITKAGGHVGPVVTKSSTIDGSTRSWLLVRMILTSAASCSTFASNASDWQRNATKPNDPILGQFIGFPLSNFIVQVIGMLVASTSEVVYGKVVWNPVVYLERLLVDNFDAAHRAGAFFISAGFVYSLLFSCVFENVYCCGNDLASLCPRFITVRRGFAICLVGSAVINPWYLLGSASIFISVLASYQIFLFSIASIIMVDYFVIAKGRIVYHDLFTANKQGTYFYSYGFNWRAFAAYFVGVAVNFAGFLTNFGIIKNVALTHSYYFAIFTTTFAAGIVYWGLSIAFPPPSLQKKWSEPKGLWDPDGELGVATTTASSSEDAEDEKVDMKGTDLGVTTDVLPALENRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFM1</accession>
    <name>A0A2S5BFM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFM1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFM1"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="256" mass="28040" checksum="E38F72FD14CAE0A2" modified="2018-07-18" version="1">MAKKARAGGGEPTAATPVPTRESLQRISYLVQASVLLRSVIPALPSSEAARRSKKRRTKDVQAPARPPTIQETAGDETTADVARPERNEKNGAGAPLGQPEHRQSKRARPDKALQPVANHLASEISSVGKKATVRIDPALKRVVCQACQTALVPGLTSSVRVKPSKSHAHMLVHTCNACRHQRRIPATPHLPDESAIAPCSANAGDDDATMQSDRRLTERERRERKQSRPAVFFERTDHIVVRGNQVVSRDEYRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFR1</accession>
    <name>A0A2S5BFR1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFR1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFR1"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18432">
        <property type="entry name" value="BRCT_PAXIP1_rpt6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="144"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="521"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1214" mass="132818" checksum="7917D4E62E5DA887" modified="2018-07-18" version="1">MASSDRPEGPIANQSLFNSVCYYLNESLRKPVRAALHDLLQSGGAQQCPPYRDGADVDADGGDQFVTPDGRPPRFDPRRLTHFITDSLDFREYDLIQALNGREPQSDRKGKGKAREAHSGATNGTDDKVHIVTGQQQPRFYSADKTLFFSGVVVSASELPPTDRRDIFQAVVALGGQSRQELTREVTHLICPSGAGRKYEMALKHGTELGMQVVLPKWCVRVAPERFEESFKHSKLVPTAVYRFPDPPYATTLRDGSSGKPFADRLFEYWRSRLPGGPNAGSTSTAAVDGPPSVIPNTATYVILGYPDASGAIPDGGASRPSDTQRYLRTTVDFASNKRKSQSAYPPDVAGDDNTEAAAQDRDDDREMDEHRGFFADKRVYLASVLALTFPMEEAFRAQISRHGGTCSSFHYGPDDFPASEQEAEDAVRNKRASTTDGADAWEARRQAEKRLKESDIVIIHVREGWEYWTAYEAGLSIGNPQYFYDCLRMQTLLSPLSRIGYYPVPSTEGLPDWPVGNHGGKPVVTVSNYAGESRDYVRTLIELLGGTFEGTMTKQTDYVISAAENGSKVSHAREWHIPLVTHLWLEALILDWRYIPPSADPSYLLSGSSAGGTHYATLLGDTPFTREVIARWAAREEVRVERNEAMRSIEELEEAERADAPVQDGAAPGSDQAGMEIDRAAGQEQEEEAPVQQRRPSLSPTIDRSPRPQSKAAESPAKPRSRTKTPRPVTADREQAEEPVQQAVPAESAPAAARQPAAEAARKTPAKGNGSKSDGARRKRDRSDSGLSSASSSSSSSDHLPPSANKMTKAFAMISGENLVQGGSRRGAAAKAQAALVDQIKDRNAFEKELKSSGRKKGGVSRRSRSPSKKVTHDDDIKDEEMSEDEAAPPAPVSKAKGKASAKPKAKSRKQSVSDDDDNDGGLEEGPARKKPKTGKAAPPVSKQVKNLQASANGTTQDGGAVSSFDRPPNAKPAPVKPKKVKIISTGLGLDKDHTDIKVNGTAEMPGTCAMLVLTEPLHAEQKMKTLGASWTDTSKDATHLVVKGISRTEKFLCSLPYAPRIVTPAWISACLAANRLIDEMPYLLKDVKKEKEIGDTLENILDRARQRKLFDGYNVYVTRQIQPDTSVMQRVISACGGTVHTKDLSKFVKKIVKDPTALVVSCEKDKREWQALAAAPHHQKIYSVEAILQAVLHQNLERGFIEDHRIDARWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFR6</accession>
    <name>A0A2S5BFR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFR6"/>
    <dbReference type="OrthoDB" id="10679292at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="396" mass="43163" checksum="5538BA741C159DAF" modified="2018-07-18" version="1">MSSPERVLYQPDQRLAPSPGFPQWPSVHGVWADPRDLLLACQLAALRFGFSDLALDESTPTENDLQIRCNPIRFGREGKTCRTVLLTACKLEGAGWQVVKARIKQTGAHVDHLGMAPTLMQAPSPSWSHLAVGLKLPSIRAVLDLEATLRVEARFANRHLLTERVVIPGPTWSKSRLIITCETGASHCSFEVVVDRVPGVAKQWLVIKSELKHTCTGRAQDPSAYLLRSLQFFACTPGRAAPQLRERSKAPSPVPAEVAVVKRERVRRVLPTLATPSSPASESDMSDGDSLHVAQIDKQGAAPAAPAQRARPSDAEGAAIEAVSMASAAVATAHDSLASAKSRLTSLHQQVREAQQQVALAEARLDRRKDRLSARSRKLNKVLDGSKRKKVRAREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFS1</accession>
    <name>A0A2S5BFS1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFS1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFS1"/>
    <dbReference type="OrthoDB" id="15893at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="137" mass="15458" checksum="6ADEA9D75879526A" modified="2018-07-18" version="1">MSNLPQLYRSTLRQFAKNSIHPRTGRSPSIPQHLRRLFESGRGIEAGSTDASRFARDVENMVVFLRSRRIHKELVDRYNPTHDMTQDERIKATANRVGLNTPLEYDPEAPRAIPTGEDGAEADDGKGSLQTMFAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFY4</accession>
    <name>A0A2S5BFY4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1309</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFY4"/>
    <dbReference type="STRING" id="741276.A0A2S5BFY4"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="52"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="455"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="728"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="760"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="780"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1122" mass="119913" checksum="151D212C5DC59AC6" modified="2018-07-18" version="1">MDGSAAVDSASSSAPPRLAPSADSHPPALGPHDAAAADDDDRELPVVLQDLVPLSYLIDRVVSSAYSDLATLIETLPGTHDDHQTKKRRVVDHVLNTRRQLVKLLVLTRWSAEAHRVHKAINIVAFLAIQNLAVDHAVDRLNETHQMLARARVRNYDLDSAIATLSLSSSAAPASFSSLPASLTDPFQLEAAAPLSDAEALETLSELNRVLLARLVLRLEPLPPRLADPSTWSIHDGRVTFTQPGLWEADMTYGGGNTEEEQGEEGREWYLLAVRFLFKVKDARGAWSAVPLGPIKDHLLDLCNRELLRRPYFPAPLPPRPITSSSRADGGTTSDPLANGESSDTAAKLAMLPDPQAAPPAPGEVPLLYPNGDAAAGEAKSKSEAEVWDEREREWKEERDRVKSKRKRDRPLERGYTFLQRLALSYQIEAIHSNAARLAATSWSGSLEVERRSFSAATSSVSAQNKSSEGADIEGEDEVRVHYWRPPPATQPQSGPGKPLRPGPSPHPSSSNVGGGAKIAPGRRSGPGGTIVFSLRPVTTTVSTPATIPSAESSLASPGKPAPSRRREAARTAALQAALDAATDPVSAESSDLPPRPSPTPPVPSSLSVAWLPSLASTPTAAPSALSSIDLTSMLGSDLDVERILRFVTAVHARETVERLANVVVGASDATRKAKLVVSPRSKSIVSDEQEEEETRVPYLHLPLVGAHAIGAYVDAVTGRFELRAVAARPSREGSAAAASRAGEDDATAAADEGSPTTSRDQRLRLASERIDRERFMPTQGASGSQGAPGPQQKGPSQGGAGQVDPDGWMKGVVEVVARIRASTILDELDTLLSLLSLPLASAPVRRLPLPPRELAKLGPNSSASAGRAAFLFVPLLADEPALAGWFLVFELFEDGIRAALMSTAERSDQLGHWSEVLEVGWLGAGAQPEAVAEGRGEASGKGANLGYEVKSETIRTLWWLCVRRASAFAIEQQLHLRRISYRREPVSGATASRLVIPSSALLRVPDLAQLLRPEAELRCAVEEDGRKRSPSEQSILLVYLRLAAGQPSPLPPPGGLPPSILYNPAKGALVLLTEGALGETVERLLRALATVVKIVRAAKPIGSPVKTPALAMHREIKLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG01</accession>
    <name>A0A2S5BG01_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG01"/>
    <dbReference type="STRING" id="741276.A0A2S5BG01"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000016">
        <property type="entry name" value="probable D-lactate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="145"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="601" mass="64713" checksum="60A9260506EC1E97" modified="2018-07-18" version="1">MLTRSTAPMRSLLRRPAATVGQIRQLASSPQVHPLSRRPTPSGPAAIRPGPQRGPRPPQREQRWSNLTLILLATLTGSVTYALGRVEGSGNSANSTTQQAYSPPTQERFDKALEEIKAWFPAEELDQSRDTLVSHGYNEWAAHGPTGLPGAVLYPRSTEDVVRIVQTASKFGIPLIPYCAGTSLEGHTTALGYPNNPSEKSAQEKLARDGHVEVDDLVPGLALVLDFAENMNNILQINREDLDAVVQPGVSYDALNAELKERGIPLFFPVDPAPGAQIGGMIGTGASGTNAVRYGTMRDNVLNLTVVLPNGEVIKTRQRAKKSSVGPDLGRLFIGAEGTLGIVTEATLKLAPLLPSTVAVSSFPTIADAAAAARDLVQNGVSLACIELLDEVMVSATNAQTKLGKGRQWPVQPSLFLKFSGTPEQMKLDVARTKTITKANAGSGFTFARNDQEAEDIWYSRKIALWSAIDYLPGAKCWVTDVCVPLSRFPELISETKAEIDAAGILGPIVSHAGDGNFHALLLFRTDEELAKVEKLVHNMVERAQRMDGTATGEHGVGVGKKPYVEDELGSGTVELLRQLKQTIDPLNIMNPGKLIPDRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG22</accession>
    <name>A0A2S5BG22_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG22"/>
    <dbReference type="STRING" id="741276.A0A2S5BG22"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="479" mass="52279" checksum="1786F073E6717A8F" modified="2018-07-18" version="1">MPRDDNLSAASTSTGRQLPVALSCETCRLRKIKCTRLDGTDSCAGCLKKGIQCVFLHRPKTRRRTGKNVEAARAQFGPATPSSNTGSEQIAATRTPLPLVSAQERLARQELVGAFGSKIVDVYVKSGHDRSTWPEVDLPLVDLWDLKLRYNRCGQRLDQLSTADQLVFRIICAYAAQSCLPDQLAGNSRRGITHEIKTEFETYADSIGIWRQTDPDNLVPLFLGYKAKETEDLTAEEAAPYLEAAIAQWRRLVRRESPASRQIADSLPTSLRWSLVVADCYGAAERRHTPLLMQAALGISASAPMRCVYDAILVFALLAHDVASYSSSLACAIESLQPLWSGLDSLYAWAQDALLVYATDIWSSAITLEFSIAEHIRSILSRVAAPANHGVGLTNTNHLASLVSLCAIANQRILTAITSNLRIVRTRHNPPLHTLGVMPALILGIGRVLDIGQAFAGAPAQDRSLFPSGPQEKLESLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGF3</accession>
    <name>A0A2S5BGF3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGF3"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015449438" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="113"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="465" mass="48023" checksum="1240CD60DBAAF584" modified="2018-07-18" version="1">MKLSILGLVVLAQALQSTAYPWMAAGSNAERAYDASVHKRAVDVEPRAVDVQERAVNIEERALLGGVLGGVVTGVGSAGSTIIGGVTGALGNLVNGLASFGASNVGSNVFPDAAHPFQAPGSTDQRGVCPGLNALANHGYLPRNGIVTAQQVIQATSEVFNMGEDLSALLCFIAVTYGGNLETQTFSIGGEDDRTYSASGVGSKAAGRHWGLDAHTRCESDASPTRQDFYMSTPAGDNHSMDPSRAKRMIQLAQKYNGLFSTPAMNELFGQNSAMSIANNPKFSTGAAYTLVVMLAAYPIIPEFFSNGTYGAGGAPTLENIAPLMGIKINSDGTICAVPEQIPQNWYRRTTPYGIANVVANAPGTLAAGNVLPSPFSNIIQQGNANEIGCFLYQALSSESPASLTLGTTDGVSSLLTGLQNQLLGGLPTLFGCSGAETANGTSVPAFDASLQAQGPGGDQVYVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGZ2</accession>
    <name>A0A2S5BGZ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGZ2"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="118"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="521" mass="55151" checksum="2F6906A1947486D9" modified="2018-07-18" version="1">MASALKPPKPGSNSAAMGFQGGGLARQITSNDLPPAEAIVATRRGEAILRERDTDATESLSLRRRSIEPGTRRPGPLKDNEEGDEKSVDGEPRQVVVTEGDEPLGLAEEWTFPDGGVKAWSVIFGCFLMSVNVQGYGMAWGAINNNLQKYHHPGTSLATLNLIVGLFNFGLNASPFVTGRLGEIFGFKRMIAIGSTLSVILLICSAVAVSSLPALFLLQGFFLGVAHALSLPLFMTIPSQWFSKKRGLATGCVVSGAGFGGAFASIVMRAILPSLGYRNSLLVYAGISAVIYLVAFFLLETRKPPAQSIPQTFDTKTGLPPGIWKDPAFWSLMIGISVGVWGFLSPSYFLTSATIHLNPSLDPNSLLVALPLILLNVAIGVGRIGAGFIADVIGPTNGMFASFFAGGVLCLAFWSQIGENQFGLMNAFAVLYGLLGSWFFLLMAPASAQLFGLRGLATIVGYVVTSQSPGQLAGATVAGVVYDATGKYSTVAFYAGSVMVVGSLCLLPARFSRVKKVWARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH10</accession>
    <name>A0A2S5BH10_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH10"/>
    <dbReference type="STRING" id="741276.A0A2S5BH10"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="126"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="216"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="337" mass="36710" checksum="EB526E0FC5D43EB6" modified="2018-07-18" version="1">MAPSLTPFGNAVVGAVGGVFSGAVVYPLDTIKTRIQTEVTAIEDAIANGSTPAPSLKRPNAPHHLPHKHTTARQMAVKILKEGGALAFYRGFGANMLNTFSMQFAYFYFYTLVRTTYIKRFPLAKLTTATELTLGALAAALGQVFTIPVSVIATRQQLAKKRLSFKRAIAHILRDDGVTGLWRGLRPSLVLCVNPAITYGMFERLKTLILKPGDKMTPFKAFVLGALSKTLATVVTYPYIMAKTRLQAGAGDDDEDDVDTKPHKHEERYNGAIDCLQKVYAEEGIFGWYQGMQAQITKAVLSQALLFGIKDALEAYTIVMLVAYSKARGSAVGLKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHE3</accession>
    <name>A0A2S5BHE3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000007">
        <property type="protein sequence ID" value="POY76198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHE3"/>
    <dbReference type="STRING" id="741276.A0A2S5BHE3"/>
    <dbReference type="OrthoDB" id="2525765at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="791" mass="85875" checksum="F247370D64A26065" modified="2018-07-18" version="1">MIAGRGTSSATAVTSSADGKRKKPPACDRCKAKRVLCHPNPAGCPRCREKGLECITTPPLRRGRPRKDESAPSPRQRSEQPAAATGIVSDLPYPHIPVSNVGSGLAPTPSQNAVGRPAQILNLSSSVAGSYEPSLNDLRGPVFRADASSSAAMAWQSMPNAGEIDSLARRVSTGLPSLNPELVRHLYDAFRQSPHFDEGLSPFSSLLPSLSSAWCGWQVDRLPRETQALAFACLSIGVLYSYDPSIIGDSPFTSFASLPQDRDLREYGRRRRPAFEEMRDLALRAAKETDVWMEPTIDNAAARALLEAGPSQRTDVLPVPRADELLTLDLRQTRPFLRSYTSHLTHLVSHGAVRPVVPLGLDPADVSHLVSNDAIPQSADYGPAIRTIHLAGAVCAEIGRGTITASQEDQDIISETTERPSVRRVEQQYRIALAAPVRDQWPEAHTICLLYIATARTLVNEVLAPHRRRAPVDVAALVRNFEAILALQSVSRLHTQVWDRIIARTAAASTDAQAQDPIRSSVLFPHIARRRVRWTRLLAAQAVGRFGAFVWATLVVPFVTEVTRRASQASTRRPDEPFKAQHDRVQLELLLQQSRALVPHAVEAQVKLWERSPSLALLALTRPIGLVETFELWIDLVEAGHLVGIPHLASSAAKALRLGGWVHSSTRIDLLIDRLDSVSLHAAPPIVIEAESARLYEMLSGPDPFTGPLPPTPPLDLEALLAEAVASADATGPLPALPLATDYTEATLALDNVGMLDLTEPFLFGETMSASDASPLSTWPPEAWSDSSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHT9</accession>
    <name>A0A2S5BHT9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHT9"/>
    <dbReference type="STRING" id="741276.A0A2S5BHT9"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="157"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="787" mass="89420" checksum="C03C0026EAE00860" modified="2018-07-18" version="1">MASAQSLSGPTGRVRSTNRYSALQSLIADQDTEIEDELARAQKRLRDLKSRISAQSKKNFVLERDVRYLDGRIALLIQNRMALDEREEVKEHLEDVDVDGEADMDERRLQQYSNLFFLLQSEPRHIASLCRLVSLGEIDTLLQTVMFTLYGNQYESREEHLLLTMFQSVLTAQFETATEFGSLLRANTPVSRMMTTYTRRGPGQSYLKGVLAERINSLIEHKDLNLEINPLKVYEQMLNSIEEETGELPADLPRTISPEDAAANPDVRNIITPRLTMLMEIANSFLLTIMTSIESRKYPEASDYAICSLIGGFFFLRFVNPAIVTPQAYMLIDSLPASAKHPRRTLTLIAKMLQNLANKPSYSKEAYMMSLQPFVDNNKTRMNQFLNALCEVPDFYDSLEYIALSKKDLQISITLNELYNTQSLLEQHIDVLARQDQDHLRVLLEELGPAPAQVPRKENRAVDLPLFSRWEMPIQDLTTALMAENNVTQNDILYLETKSIFVQLIRSIPRLADKRPILLPIVAETAATAKDATLVRKGIKVQDMLRELEELRLVDRKDNYRLLTDEVSAELAHLGNLREKVVLETRSLEAVYKTICDHNTYLRSQLEQYKAYLQNVRQTSGGGKKGGVGVVTVAGKEQKPQQVQVLGPYKFTHQQFEKDGVIVETNVPENRRPSIYFLVTSPSPGAFLIALHYKGREKAILEMDLKIDDLLEKKNQGVDSLDMEYVSLSVNKVLALLNKCAVHLFVSVSEPLANLETRPQGNFRGGNSEPAPSIWRLPFRTLIYPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIH0</accession>
    <name>A0A2S5BIH0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIH0"/>
    <dbReference type="STRING" id="741276.A0A2S5BIH0"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="57"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="167" mass="17903" checksum="3CD2CC3BB0B391EC" modified="2018-07-18" version="1">MFRTALRPVTRAAFAPCARSLVQPSFRTVVNLTLVSLIAKRYTPEHEWVSFDDATGLGTIGITEYAQKALGDVVYVELPSVNTEVASGEEMGAVESVKAASDIFAPVSGKIAEVNGELEGQPDLLNKDAEGEGWLAKIQLSNPGEFEQLLNDEAYKAHCAGESEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BII7</accession>
    <name>A0A2S5BII7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BII7"/>
    <dbReference type="STRING" id="741276.A0A2S5BII7"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="296" mass="32747" checksum="007297FEFD6E9C18" modified="2018-07-18" version="1">MAVPDFEAGVNYWQNTSADVNGVLGGYGEATPVPRLDATSSRLLILSLLPELSTIPAPHLPAASSSKASTRPSRPFRALDCGAGIGRVTSTVLLPLFDLVDLVEPVPAFVKQAKKNALHGGEGWRSLREDAGDKRKAVRVWKAGLQHFDPRCPGRPVDAAKGTVELFARVGREEPSWPAKDAEPREVGVQEDGYDLVMIQWCIGHLSDDELVEFLQRSRAALRQTPEGETTGWIVLKENTCKDEVDRIFDEDDSSFTRSDKAFREVFKRAGLTLHRREIQQGFPEELFPVIAYALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIP8</accession>
    <name>A0A2S5BIP8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="4">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIP8"/>
    <dbReference type="STRING" id="741276.A0A2S5BIP8"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="588" mass="64836" checksum="EFE7B092F11E6787" modified="2018-07-18" version="1">MLPPFKSVPLKDRTWPDKRITKAPRWASSDLRDGNQALVNPMTIEQKQRVFNLLLKCGFKEIEAGFPSASETEFSWIRGLIEKDQCPDDVWLQASLAESRLVLSPAREELIRRTMAGVRDAKNVIFHMYNAAAPIFREQVFGNSKEQTIALAVKHVKLVRQLVDEAIARGDRTKWQFEYSPEAFSQTEPEFAVELCNAVQEAWFAGKDKSKEAPIIFNLPATVEVATPNNYADQIEYFCRNVKDREHIVVSLHTHNDRGTGVAASELGLMAGADRVEGCLFGNGERTGNVDLVTLALNMYTQGVSPELDFSNLEECIEVITQCNDIPVHPRAPWAGELVFTAFSGSHQDAIKKGFHHRKADESKPWQIPYLPIDPADIGMTYEAVIRVNSQSGKGGVAYLVQRALQLDLPKKMQPAFYQVVQAISERTAKEITGDDIEKAFRASYYFGEQHSGRFDLVDYSFATGADGKKTFEGTITDNGEKQSIRGDGNGPVSALLNALNSAFDGSAHNLEVREYSEHAIGAGSDVKAASYVCLVDQKSGRSVWGVGVSTDVTEASLRAVLSAASNAAVPADRRMSEIEDVVIGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIR8</accession>
    <name>A0A2S5BIR8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIR8"/>
    <dbReference type="STRING" id="741276.A0A2S5BIR8"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015484163" description="AAA+ ATPase domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="204"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY76669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="427" mass="48168" checksum="0A216B6050274766" modified="2018-07-18" version="1">MSFALLLRLYTLRLPSVWLKQAPPALTRPSRKLSQRIARRVDLTFTRRRPDLKLKEHEELDGNLKKIRLSLKDLERDFDKSEDDIKALQSVGQIVGEVLKQLDEERFIVKASSGPRYVVGCRSAVPREKLKMGVRVSLDMTTLTIMRILPREVDPLVYNMTMEDPNGASFAGIGGLSDQIRELREVIELPLMNPELFARVGIKPPKGVLLYGPPGTGKTLLARAVAATLSTNFLKVVASAIVDKYIGESARVVREMFAYAKEHEPCLVFIDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDHLGKTKVIFATNRPDTLDPALLRPGRIDRKIEIPLPNEVARAEILKIHAGPIRKHGEIDFDSIVKLTETFNGADLRNVCTEAGMFAIRDERDYCIQEDFIKGARKLQEAKKHETILEYSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIT9</accession>
    <name>A0A2S5BIT9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-coumarate--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIT9"/>
    <dbReference type="SMR" id="A0A2S5BIT9"/>
    <dbReference type="STRING" id="741276.A0A2S5BIT9"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="480"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="64538" checksum="BD9019E61AA7837A" modified="2018-07-18" version="1">MPYNDKTGIYTSTYGSIPLPEQAQTIYDFLFESSPQQQVVDPRGRTWLLDAHSNRSYTFEQARERADDIARALHEKRDLREGDSLVIFAPNDLDYGPALWGAFRQGAVVSCANPAYNADEFAHQLRTVHSHHPIKAILVHPDAAVATVQACEKSGISSSSVILLKKADSSSKNVEGLAEGLVTLDELVATSRSANMPAKCKVKQGEKKTKLALLSFSSGTTGLPKAVCIPHWAVICNVLQAVNFEHRTLPLEAYDAREKKGDVVIGCLPFYHIYGLVVVLHSSVYQSTPVVVLPRFEPRAFLQTVQDHRISALFLVPPQVVLMVKQDFVKEYDLSCVRYVMAGAAPLTEEVVKAFKQRFPKAKVGQGYGMTESSTIISMHDGSDDFPGSSAGKLIPNIEAKIVSPEGKALPPGEVGELWSRGPSNALGYLGNEKATRETFDEEGFLHTGDEGHITNECLFIVDRLKELIKANGFQVAPAELEGFLLSHPDVQDVCVIGIPDEKRGEAPKAFVVVSPSAASRFKSGGRQAEAKLDSELKKYVTDNKIRYKALAEIEFIDAIPKTPSGKLLRKDLRAMHAKKVKNKAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZ91</accession>
    <name>A0A2S5AZ91_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_7111</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000179">
        <property type="protein sequence ID" value="POY69887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZ91"/>
    <dbReference type="STRING" id="741276.A0A2S5AZ91"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY69887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="164" mass="18749" checksum="1219AEE578A0CAB8" modified="2018-07-18" version="1">MRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRVNEAREELQRMLNEDELRDAILLVFANKQDLPNAMNAAEITDKLGLHSLRQRQWYIQSTCATSGDGLYEGLEWLSSNLKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B056</accession>
    <name>A0A2S5B056_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dimethylaniline monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B056"/>
    <dbReference type="STRING" id="741276.A0A2S5B056"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="71121" checksum="A173EC9C10924073" modified="2018-07-18" version="1">MSAMVSTEWDSIIIGAVVARHADIATLTGGPAGLIALKTMSENGLQCTLFEAESDIGGTFKYRAYEHATLVSSKQLTAFSDFRFPPEQGDHVTLPEYVEYLRGYCDEFKLWNRINLDTRVVSVRRGEKGQGHIVDVQKKGKQETERYRCKYLTICTGLHVIPQVPELPGVEHVEADQKKTVIHSSEYKERSQLAGRKVLILGSGETGNDIAYESVKAGAKEVVMCSRGGFLSFPKVLNNFSILGSTFDGDLPIDGLITNLFESAYVHPWVARIHLRWFVSDFVIKRVLWALTGTSAGCNQWVGELPPERLGRAYVFLMKSHRASTFLNRPYRKRSPLMSYLSEYHDPEEDAKTPGVVEMAPWPTGFDEDGVVQWDWDKCEARGGSWKKVRRRMEQKRIEPDLVIFASGYRQDFSSWLAPEYPRPWEASMRDIIKPDVPDVAFLGFVRPGVGAIPPIAENQAMWWTAWLTGKMPSLPTTPSNYYLLSAPTARIKYGVDHTTYMHTLAADFGGSPSLSELWRTHGAFVTLVYCFSAAFTSHYRLVGPFKSPKAPEVVKTEIWETVTRRGLLGNLFMGLIPMMFYALVNGFALLLETVWIACGRPDVIGWYRRLSGRDDAAAQLTSDQKKPTLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0K0</accession>
    <name>A0A2S5B0K0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0K0"/>
    <dbReference type="STRING" id="741276.A0A2S5B0K0"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="9">
        <location>
            <begin position="33"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="386"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="65979" checksum="A0A3DC64A5E87831" modified="2018-07-18" version="1">MLIEQSQITVETQTGPLGIEIIKPSKLSKIAGYPNARFPGVVVWSEIYNVTGPVLRFANQIAAQGYIVAAPNVFHEFAGNVPLAYDEKGTADGNAYKVKKLLSATDEDITKSIDTLVAHPNCTGQVGATGMCYGGHLAFRTALDPRCKAAVCYFATDIHSATLSPSGDDSLERASKGEIKGEVVMIFGTQDGHVPLEGRNKIRNALTAESVQPPLRLSFLELQANHAFIRDEMSKGRFDAAISKVCFELLLETFGRTIARDLGEPVQEKKGDDLNAKDVFTVMDVIRRQQQQQQAGRGMTSPRYRHDPRQGFSWHNFKAYIRSPFFIILVSGGGAYYLFHLERVPETGRWRFMDVSPTMEVEMGEQAFQETIGEFGRNVLPDHHPQARYVQGVVKRIIQANGLEGKAPSGWKTYVVKDDSTKNAFVLPNGTIFVFTGILPVAADADGLACVLGHEIAHQVARHSAERMSGMKVFYGLALLLASLGIDMGLSQVLLQFIYQLPNSRKNETEADLIGLRLANQACFDPRAAEGLWHRMSATEETPGVDMSFLSTHPSSKNRTVQVRKWADEIIQDRPSQCGPLRHQIEPFQQATRSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0R1</accession>
    <name>A0A2S5B0R1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0R1"/>
    <dbReference type="STRING" id="741276.A0A2S5B0R1"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="327"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="922" mass="99530" checksum="05E7C85E0EA057B1" modified="2018-07-18" version="1">MTMRAVVPRRRDSTAPKSGKAGVVGSDSNPQPFLRWAGKTVPLVEEAVVSPPPVGAKDHSSTASTPPPDNVSSSPSLDRPPVRPPRPDSLDKDSFATLADTLSPIPSPALKSPAKFESPLAAESASTFADLEIQFDDIISTYSTNPTKAGGAVSPLLPTDVTPAETLVEELPAAPAAGAPTPADLQIEAIQAKLAELGMDAIDTRPAKVRIVPGTERAQTLVSLERRTAHLSGTPLYADRLALLQRLEVAMGAFLRVEDAETILLIEKPVPEEASSSRIDQTQRGMLGRLRSSWRPQSRPPPVVPPRPDAVFGVQLRAIPGDAFVEATLANQPYELPIVCFAAVEEIYRRGQGAPVHAFMTAQGSATRRDQLVRIYETEPDFGERHDLSLESVHDVVALLKHFLISLPSPLLDERLQKLFVSACVDSPRPLASRITCAQLILRLLPARNLHLLLYLIAGFSQLPLCARNPVAPEKIANIFGPALFAARMLASAPLARRSSLSISGPTDVAISSRKAAESAENAMRWLLDHWSAVAEGLLATSKDVAITQQKQGSTETLHISVEAPAVVSAPLRAADEDAKSMRPRKLVEPINIPTEAATSASSSVRPASPSSEPPLSPSQSCSSVCSNSVETPGEPDSPHLRAEDAEDANLALQKQLDEAIAMLTVRRPSADDPDNASVYAFPTPPLSPHSLPKTAGLGSLEEQQTAMLPRTPIKHRRSRSADAFTLSRPAPPTLSRPASAPRIRAPLSPTWNAPTIPEEGTPPPVPLKRLSLQAASSAPSSTKRLSQPPAPRAGTRNLLLPTHVRRYDEIVLLRQQLAILEKERAAERVDMADLRSEVEAFKARTTSRLQSEEEERVSQAERRAVDAEARAAEASKEAQEWRERLVEAEHLRKREASEARKTAIELENQLQALKALMLDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0R2</accession>
    <name>A0A2S5B0R2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0R2"/>
    <dbReference type="OrthoDB" id="2529826at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="400" mass="41524" checksum="66641EA698032C5C" modified="2018-07-18" version="1">MANKAAMKRKAPAAPAVARRGKGKAVSLVPTGSAQPSRKRAKLAASKPPRAGLDASESEEDGRTNKSTAGRDEGDEADDAHAAMLAALEAHQASFFGDALPFASTSSGGAGTGKKGRTSSAATQKSVWEMDDDDFLDEGDDDDDDEEEDDEGSEEEDEQTGPMSNAAKAARASAATVVAFVEPGRGPALALSAGETAPPPMSKREMRDFKAGKVKNLHVKPSIADAHNAKYVGGKAAKQKAAAAAGDTKAVASLEKQAEDEVEELHLSKLDSHLSSLIQPLTSGSGSASLPDLLRELPIASSKPLKGHTPLPKNAPRMLRRGQNAANLKRAQARDDAAGFGKGAKKGAVGMGREALSLKEKRKAEGGDKRQRGIGAAAGKWGRGQISLSKKEIRSINGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1A1</accession>
    <name>A0A2S5B1A1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6509</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1A1"/>
    <dbReference type="STRING" id="741276.A0A2S5B1A1"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="586" mass="62479" checksum="8CDC339FDCEA801F" modified="2018-07-18" version="1">MAADSSTSDDAESGPLLRSYGYGAHDSTDASTSDDKEQELHDSIGYKRLRRGFCAYSIAGEVFAIVSASLFLPVVLETYARQHGVLSTGDRSLPCPDSGSSGDLEADARCIVQLGGAWIDTASFSLMVYSASVAVQALTVISMGGIADDAHARHRLLITFAFCGSGLCICFLALAAGSSLWPLAAVLALGANVTYGASNVCMNAYLPDLGRRAPAVLRAQAELVRARTGYSTSRRRMSSTSSNTLLSSSQVLAHATDAYIHARARATGEVSSRAIAYGYAAGISVLAALLPVMSWLASRSSGNDATGPLRFAIAVSGTWWLVGTVFAAIWLRPDQEPSPATGRKLSYTASIAQGWQGLGRMLGEWRRLPQAFVFLGAWFLLSDCFATITSTAVLFAKTSLNLPTSSLIIISILSPLAGLFGALIVPRLQHSSTFAHLGLTTHRTLMILVASATLIPLWGLLALRTAWQMYALSCVFGFIYGSFQAYARSCFSDLIPSAKAAQFFGLYSITDKSSSFLGPLLVAVVTNQTGEIRYAFWVILSLMVISLPVLARVDVKAGSADAERYENEVKALAMEEDVLPDEVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1G5</accession>
    <name>A0A2S5B1G5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcipressin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1G5"/>
    <dbReference type="STRING" id="741276.A0A2S5B1G5"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="40261" checksum="5C96264D3D54EA93" modified="2018-07-18" version="1">MATRLAAESDPEGQRRATKPSPRKRTRRPPAAPSNVLILVVPSLVLHSSLLPAFHAHFATYGILHAWTPLPAFGRVVCVYETEAEAQAARDEMDGFFWADEVDLKARGLDPGQAYEPLRAYYGPPFPPSRFVHLAQVAEASQAGSAAGSNSAGAVDQHLTVPSSGRNFLISPPGSPPVGWEQIAEDSPNTRTWHEGDEPPTPRTRQVELEELKKAASPDQAWADELARALRFLSVDAGGGGDDDDEEAEVMADEGEDTAMQDDGGGDDAGLGSTTHIVLAPAPIPALSARAHLLSATGGSAGGARALRPAVTVSSPVPTTTSSAGSSHPPTPPSTTATPPPGASKISSVKATIESMLPRTEEGGAEADQLSRGGPRFIPTARPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1M2</accession>
    <name>A0A2S5B1M2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1M2"/>
    <dbReference type="STRING" id="741276.A0A2S5B1M2"/>
    <dbReference type="OrthoDB" id="2507344at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="222"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="710" mass="77320" checksum="F73CF622889F9E3D" modified="2018-07-18" version="1">MDEARALLRDVWGYDGFRGVQEDVIRRLVVDGENALCLMPTGGGKSLCFQVPALLLDGLTLVVSPLIALMKDQRDALTARGVAAASLDSSLSVEESTAVRQQIREKKLKILYVAPERLNNEMFVSMISEQEIALLAVDESHCVSEWGPSFRAEYLKVSRFAKEIAAQRVLCLTATATPSVVKDICDPENGFNIELEHGVFSTGAFRPNLSLLIKPCLNFKSKVALLVPSLKGRGDGAAIVYVTIQKQADELATELTETHKLDARSYHAGMSADKRKEVQEWFISGNGIVVATIAFGMGIDKPNIRVVVHFQIPKTLENYSQEIGRAGRDGLPSTCVMLPSSSDMPILESFARANTPSKQSLHVWLKSVSAAPVDKDGTISANHYEQSNTFDIGRNTLSLLFTILELQCGLLRATTPFYQEYNVKPLAAAPMAFENIGRHDTKESRALRSGWKTGKTWTSIDVIAISEASGIDRTELVRQISRWEYSGWCEVKVAGVRSRYRVLEDLPTAEEDIQQLAEQLFKQLHDREEADVARLRSVAEFVKGGTCYAHELANYFGDDKSVPGGKCGNCSFCKTGLAIPFEPKYDAPFSDKQVRWILAVCGVRDDPRMLAGLAFGVTSPRITALGLSKHDVFGCCATADFGKLLERFEAECAECGFKNKAVLAPPKEVKTTGAAAKAGPAKSGSTAKTPAKRAAPAKTGGGAAKKAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1S6</accession>
    <name>A0A2S5B1S6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1S6"/>
    <dbReference type="STRING" id="741276.A0A2S5B1S6"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015367932" description="Dipeptidase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="444" mass="47731" checksum="FD63605CBD4E2127" modified="2018-07-18" version="1">MLWTALQLALAAVACVAADSQYEQVHFGAPAALSGETSDAQWLVEARNILSRHPLIDGHVDLPYVVRHLSTRPLDVLPDLATGLAGHVDIPKLRAGKVGGVFHVAYAPCDEEPTGPDFLQPTNSVEWALESVDLVHRMVEQHPEELALATTAQGVRDAFADGKIATLLALEGSHHLMNSLAILRLFAQLGVRYLTLTHTCHTSFASSAGDGSPIEPIHDGNGLTGFGRELVPELNRLGMMVDLSHVSDQTMLDAISLSKAPVIFSHSGARAVCDHPRNVPDNVLDLIGPGADQNNGVVMVVFYPSFIDPHNATHIRVADHIEYIATRCGKKHVGVGSDFDGMRESVAGLEDASKFPNLIAELLRRGWTESEIADLVGGNVLRVMEDVEAVKASLAGESASPAVYEKRSGHDLPVVWGGPGGEYLPQDVADEVHKRFGERNEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1U1</accession>
    <name>A0A2S5B1U1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="9" type="ORF">BMF94_6158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1U1"/>
    <dbReference type="STRING" id="741276.A0A2S5B1U1"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="260" mass="28489" checksum="CBCCF85B53E583A7" modified="2018-07-18" version="1">MLSRTPRTLVRPVAWRVISRSHSSHAAPPAFVPGASTSADTEVPYADATQASSVYLPQPKDASPLTAEQIRATTESPPLTPRQREIIDKIIRVDQAGELGANYIYRGQRAVFGLGSDRKTTQIVQDMWDGEKKHIATFDKLITQHDVRPTALYPLWKAMAFGLGAGTAILGKRAAMACTEAVETVIGEHYNDQLKDLKEEFPGHPSIPLLEKVLTEFRDDELHHLDTAVENESQQAPAYALLSAIIAGGCRLAIEATKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B226</accession>
    <name>A0A2S5B226_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B226"/>
    <dbReference type="STRING" id="741276.A0A2S5B226"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="83"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="520" mass="56095" checksum="69798960223AC051" modified="2018-07-18" version="1">MAAPAPPPVDTNKIHSEEELHEDATRPHLGARFSDGKSLSEYTTNLSEKNGSSRYANSTIGLDLNGEARRSERKLVAKLDRLILPLAFLLYLFANLDRGNLGNAKLQGLYETLLDNNPTKYSIALCCFFITYIVFNIPGILAAKRLPPSRTIAAGAFLWSLAASLQAATTSAGGLYACRLFVGIGEAMFGNAIAFYLSLWYKQSELSKRIGLYIGAGSLAGAFGGLIAYGVAKIKSPAIAPWRILFLIDATPCLLLSIIVAICLPNRPDHTRYLNADEQVLATTRLNSENGSNKSLAIDWKAVRHALLDWRFLVLATCYTCMNLSLASVSGFVPTIIKGLGYSDANAQLYTVPPYACGLAVMMITTTLSDRFKTRGIFVVAVFGISVVGWAMLMAIDPVGITKGGLRARYFAICCVVGTGASNGPIMMAWLSANSPSESQRAVGASFAFPSTEGPRFVRGSAVNMAFAVAGMVLAASLSVYYRVENRRRDEQEGGRPAPGIPIEDLDTLYDRAPGFRYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B266</accession>
    <name>A0A2S5B266_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B266"/>
    <dbReference type="STRING" id="741276.A0A2S5B266"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="491"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="841"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="975" mass="106035" checksum="83947436C9EB8BEE" modified="2018-07-18" version="1">MAVAAATRTIVTSDVVESDRPSWSTLERQYQQGIAALNVVAVPVVQPADLPEPIGLSRERSASKSSSEMSAGAEYAREVYEEKGYLPALPNPREYERQRVLRRFDLHKARPQGGMRSIDDIARLAQDVFGVETVIVNAVLEDRTFFVSSAGWTDEPQAQVEIPIDVSFCPHAMTKPADAGCFVVPDAAKEWRFRENPLVQAERPIRFFASANINLPRVNYSNPDDAERLPIGSLCLVNPTPRAPLDDKEEQMLKRMANMVAKEIELGFQIERQKLYDTRLDFVSHLFQKLIVHPSRAMDTPAPGDALPCAIRGLSEKLSALTSSDFAFVLDIRDLTTAEQARQGAGLGRLSLLDCACPPFCANDEKAQAAWRARLCGEEGLQAVSRAITDWHEDEQITFTQTISPDGSVGALPTPLAAFLPPDASAAIACPLFDHQGAPSLLIVVGSLERHFQFEPSDQRFVRNVGGVLIAGMLQEKILLSDQAKLRFVGHVSHELRTPIFAVGSQLELIRNLAGPEALGTISPLLDVAETCLTSLREILDDTLDYTKLQNRSVDTVDELTLVSLDDLLVDVVHACHTKTRRLASMHAEYAPGEKDVIFQSSVPANVRAKVDVGGLKRVLINLLANAIKFTNQGTITLTVSVDTAATSDSKARFFRFECSDTGRGMTPDFVRDHLYVPFKQSDPFAPGAGLGTSIADNIVRRMGGSLRYNSTLGKGTTAIVMVPLEVVIDASGSPEPRSVTRNLSGELEALLTPRASRSTSPVSPNFSRSCKTNGSPTTVATAATVTAAAHTNSNGGQLSTPPQRNVTTPLKLEQAVALDAAPRRRTKPAPIALAHGEHLKLLVVDDNPIARRIYCTWLKNKGIAFVEAADGEEAVAQFRTHKPNLVWCDVQMPRMDGVEAATLMRQCEEAVSLPRARIIAVSGLDSTHGQHATVINNGIVDRWLVKSGQTLRDLGADLSTFAERLAKRSASTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B281</accession>
    <name>A0A2S5B281_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CipC protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B281"/>
    <dbReference type="STRING" id="741276.A0A2S5B281"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17296" checksum="455D381503215C82" modified="2018-07-18" version="1">MIAAGGGTGSCPAASRERVGSALDSPLPPSPHPHALLPFPTSLQHSQHSYIMGLFDFFEENSFQAQAAQQVQTEHKSKLSHELIAGAAAWEAQKAYARHCEQNGKPESHQKARELFAAFAAAEADKLIETKGLDFMDREEVKRQARSHANEVITDVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2A7</accession>
    <name>A0A2S5B2A7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2A7"/>
    <dbReference type="STRING" id="741276.A0A2S5B2A7"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="58"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="470" mass="52250" checksum="CF6DDDDFCB7FDBB1" modified="2018-07-18" version="1">MAARDWDDKSELGFSKDEFNAASNVVSKGGKYDGQVDEGIRPEEDLHRRLKPRQIAMYWIVTANNLVAAAIVVTYWTNAVPVGAWLAIYLGLNLLGIKVFGELEFWASFLKVITLTGLIIVGLVIDLGGAPGQERLGFRYWKEQPFSHYIFQNKTGVFLGVWSCMVTALFAYSGTELVGVTFAEAANPRKTVPATVRRTFARILIFYVGSIFVVGLLVKATDPALLATTKKATSAAASPFVLAIERAQIKVLPDIINGAILLFVLSAANSDLYIGTRTLYGLAAQGQAPRILMRTNRFGTPYWCTAVCSLVSCICFLAVSKSAKTVFGYFVSLVTLYGALTWLSILGSHIAMMRAMKAQGISRDELPYKSPMQPYMTYWSFGLTAVVTFFKGFDSFTPKFTKTTFVTNYIGIPIYAALYIGYKVWFRTNTIKPAEVDFVTGRREFDEDEAMWAEQEDPNKPWWKKAWDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2E3</accession>
    <name>A0A2S5B2E3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2E3"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015496683" evidence="6">
        <location>
            <begin position="20"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="571" mass="63229" checksum="2318E5756691DCD7" modified="2018-07-18" version="1">MRIAGILTVAAWLCTTVSALERRLTADDLTRKGTSPALPLGLFRHLERTEVATRPAVIGGVDSKTRQLPFGASTASKGSHFGPHTHDQRVSHLDAGTETFKQRYWFDATFYKQGGPVYLLDGGETDGEDRIPFLETGILRILAEATGGLGLILEHRYYGESFPVANLSTDSLRFLTTEQSLYDSAHFAQTVVVPGLEKHNLSDVPWIYYGGSYAGAKSAFARKLFPSVFWGAIASSAVTTAVVDFHDYYTPIMDHGPTECIERLVEHTSLIDSILALGTPFLTSRLKEAFGLGNITADADFVNALAIPLGSWQARNWDPAVGSTRFFEFCDALAVGNSSSLAAVDLPSLPKDPRKALESFQGYASYVKEHVAALCPPDTTQDECFGTDEYTGDDLEDAPWRSWSYQFCTEWGYFIGHGPDPEAPSIVSRLLDTEYTGKICRLAFPDGKLNSVPPVPNVTTVNQYGGYELSYSRLAFIDGSEDPWLYATPHSPLAPKHGRRPDTLSEPFKLIPGGVHHWDQNGSPDLKRSSEPKAIRRVHAEELAFVKEWLREWDDSRRWKWRASGRSRRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2P5</accession>
    <name>A0A2S5B2P5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2P5"/>
    <dbReference type="STRING" id="741276.A0A2S5B2P5"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="200" mass="22833" checksum="8B0F9EAECA68EC12" modified="2018-07-18" version="1">MATTVISSLSSYSSYRDSRSPLPINVQHANLAVSSTVYVGNLSFFTTEEQIYELFSRVGDVKRIIMGLDRNQKTPCGFCFVEFFAHQDAVASLRYVSGTKLDERIIRCDLDPGYLENRQYGRGRSGGQVRDEYREDWDAGRGGWGHLKNREEMEAQRQREVEDTYRSDHDASGAGREVPTGAGMPDENPRFREERDDRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2T7</accession>
    <name>A0A2S5B2T7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UNC-50 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2T7"/>
    <dbReference type="STRING" id="741276.A0A2S5B2T7"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37739" checksum="30BE8F6000589E28" modified="2018-07-18" version="1" fragment="single">PELGNCARCVGTTSTLAPRLLSPPLACPAHSLQITKRPCYRHLEAVDLRTGESHSRPTTTRLACTADPPDLDNSHSGYSGRLTSNGNSYSALGTGSNTGAGTTAGGTGGGGFKTWSRRLSRWPQLDFELAVWQMGYLCIAPRRVYRNVYYHKQTKNTWARDDPAMLLLITLCLVVAAVLWSAMYAHYGIVGTLETILSFVLVHFFLAGLVISTSLWALSNRFLRHATHVHATDQKVEWPYAFDIHANSFFPFFLQLYVAQLLLAPVVTRSNWVCLWVGNTLYLSAFTQYAYVTYLGYNALPFLIRSELLLFPVAIFAAFYIVSLLGFNISHVVLEGIFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B308</accession>
    <name>A0A2S5B308_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5482</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B308"/>
    <dbReference type="STRING" id="741276.A0A2S5B308"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="151"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="258"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="39470" checksum="48B636D3C88B9F5B" modified="2018-07-18" version="1">MTLAQTKLSDPSVAPAGDLQARGNFPAAIQAPSPRTPSPPAYVLSWTPNVPWRAIPLPPASAFFAGALAGAASRTVVSPLERLKIILQVQGASSQYKGVWAGLVKMWQEEGFRGYMRGNGINVLRIAPYSAVQFSSYELFKGVLTSADGSVDTPRRLLAGSLAGICSVVSTYPLDLVRSRLSVESASLGMREARTDGKSTGIVGMTLKVMREEGGVKALYRGLVATSAGVAPYVAFNFASYELLKLQLIGRDPEHHQPSTLAKLVCGATAGAISQTLTYPADLLRRRMQMVGLKSQALGYEYTGAIQAVKIILRTEGIKGLYKGIWPNLLKCAPSMGTSFAVYESSKEVLDAYFEERSDQDEVLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B356</accession>
    <name>A0A2S5B356_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B356"/>
    <dbReference type="STRING" id="741276.A0A2S5B356"/>
    <dbReference type="OrthoDB" id="2326446at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25017" checksum="343D7FC9870B7E1E" modified="2018-07-18" version="1">MTATKVRAIRFERFQPDSPTELAELRRQRVLCGWGTEEGTIEKWCEQVQRGVKNLYWIWTEPAPVFPEQEHLNLEREKVGPPPPDPAFTPVGHVSLDWEDYGGEDELADKSKGILTLASFFILVSQQGGGLGSRVMKEMEAMAAGPELDASFVTLNTLDGEVSRQPEFWAKMGVAPGRNNEEWYTRLGYEAFRRGIPRYPSKAVDGTEFLAEAVLMRKRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3F1</accession>
    <name>A0A2S5B3F1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DBP5</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-dependent RNA helicase dbp5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BMF94_5619</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3F1"/>
    <dbReference type="STRING" id="741276.A0A2S5B3F1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="22">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="148"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="335"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="POY71307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="513" mass="56090" checksum="4E54830AFDB14351" modified="2018-07-18" version="1">MASDAVSSLSARLSTLDPSGESKTPPAAASAPAPAPEPTESTPPATGEAQVENGDAAEPPQGESICVIVHISLADGGCPFCDATASSLLENLSHEVQVTLADQQADPNSPLFSAKTFEDLNLHPNLLKGIYKMGYQKPSKIQEKALPLLLQNPARNMIGQSQSGTGKTAAFALTMLSRIDMDLKAPQASSFAVCIAPSRELAMQILSVVQRMGEYTPVECFFAGKDSWTKGMPKLTQQVIIGTPGTMIDMVTKGRVLDLREVKVFVLDEADNMLESGSMGDQSITLKNLITKMAKDPQIVLFSATFADVVRNFAVRFAPGANEIRLKQEELSLDAIKQFFMDCDNEEHKYEVLVELYNLLTIGQSIIFVKRRDTADEIARRMSAEGHKVVSLHGKLETTERDAVMESFRDGKTKVLITTNVIARGIDISQVNMVVNYDLPLDAQNRPDPETYLHRIGRTGRFGRQGVSINFVHDRRSFENMEAIRKALGKPIVRVDTSDFEQMEATLKAALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3S8</accession>
    <name>A0A2S5B3S8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5751</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3S8"/>
    <dbReference type="STRING" id="741276.A0A2S5B3S8"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="868"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="933"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY71438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="968" mass="104600" checksum="6E504BFD68D7CB86" modified="2018-07-18" version="1">MRSFGPDELRRKSQRLSSLLFQHDDASATAAAAAAAAARDPSEASPLLPPPTTPIRSNAEAERGRDERGDWVSPWTPRTAPGRSLSRGRSSYFGTAGVANAKSVGGGYDAEFRADLEKEGGSGVRSWYDNFTAIDWCHDAVKHSLRLRRLRRLKQTHGLRGYLLNLWDGLQGWVLVSIIGFLTACIAFAIIRSEMWLFDLKEGYCAQDWRRAERFCCAGSHDDAGGAACPEWRTWSRVWQERGGREPTLVALLAYAGIALAFATLASTLTIYFTASTSVYSSKDSSSVPAAGQFATEARKSYYGAADLSPAESTSETDDLLKPRPRKTLYYAAGSGIPEIKTILSGFVIRGYLGSWTLGVKSVGLALSVASGLSLGKEGPFVHIASCVGNIVSRFFRKYDRNEAKRREILSAACAAGVAVSFGAPVGGTLFSLEEVSYYFPPRTMLRSFWCAMIAAMTLKILNPFGSGKIVLFEVKYDRDWHSFELVGFVLLAVFGGVYGALFCKANVAWTKHVRNGTFLKRHPIVEVALVTLLTTLVSFYNPWSKMGGTELISALFAECQKDDNQSGLCIARPDQVFPLVGSLLLALVLKAALTTITFGIKLPAGIFIPTLAVGALAGRSAGLLVEWLHARRPSSFVFEACRVASGENGPLPFGQACVIPGVWSIVGAAAALAGVTRTTVSLAVICFELTGTLTWSLPTMLAVLLAKTVADAIEPRSIYDLVIEVADLPYLDAKTEYLHDASPGDILDVEAPVISLDTDHTLSSLHAQLAALYASGAAGGFPVTGATDSIEAEHGNSRIYAYIASKELEHALGLAMAQGLPATTPCTFRAAQAARRGLGGGPSTSVPLSGFATPGEIDTSAFDLSWLTDQAPLSVRARSPMERLHEMFVKLGVRYVAVVDDRGLYLGIIEKHRYLAYLQWLEKRARSSDFAGFPSMTGTRSRQEAQIEEEETDENGLLRRRRPGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B469</accession>
    <name>A0A2S5B469_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B469"/>
    <dbReference type="STRING" id="741276.A0A2S5B469"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="296" mass="30497" checksum="DE42A87D0789F0D8" modified="2018-07-18" version="1">MSSAQNRLAAVSGQLSASQPKGLLGGQVAIVTGAAQGIGKACAVLFAKEGAKVVVADLDESKADAVAKEIKQAGGQAIAVGGDVTADDFPKKLVSKTIEAFGDINVLVNMAGFTADRMLHTTPDDMFELMLKVHNTAPFRLIKEVAPYMRSKDPKDKNKNRSIINISSTSGLHGNVGQANYATAKAGVEGLTKTVAKEWGPFGVRCNTVAFGYITTRLTQAKELGEAIVVNGKKIPLGIPSGGAHAQPASDRVPDIPLGRAGTPEEAAAACLFLASGDLSGYVSGHTLSVTGGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4E2</accession>
    <name>A0A2S5B4E2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B4E2"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="494"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="656"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1476" mass="159561" checksum="5C86AC72673B5075" modified="2018-07-18" version="1">MTEERPHASAAGPSADPVPATAFVETTNETAVRAFVERVAQVNGSLNPGDLVQTSVDAKGRTLYRLSLAGLDDPEPVQNAHLRSPKTPFALPFTRPARSPLARSADRPRPPTERTSLRPTRSIPLLRVEAAGNGQTASEIDAVAPGATGQRYLRRVGSSPLLNGSGEASTPRDMRALEAFPVGRVTKARGDGTGDIIGRLLTWRTAKPAAPTSRADDVAMDLKRQDGSQPDGSQSGLLTSGASPADTGPHVPSYEIAKAADPGREHPTARPRTRHSHAQQPFGTGVRLPPVSSSGSLQGSQVFASVPFATEAPTLPFMREVSSSDSIRTAKADAHASHAPIELTAVPAVRSYDPAIFDAFHPGTASGVAFPTEPSTQPHRLPFGHHGRADSTRSVASHRSDATESSAHEITLVPTAGDDPRYVLWGEKSKKSPATLASASATPTRMRRRASPASSATDSPVSADRFPHSDSRSSPASSVRQSVGSTVEDIRVPRERVLMAATVERLVAELTSQIAPDLLADFFLTFRSYLAPLELMHLLLTRFEWAMKSDPPLPPERDARPALASIDDAENAALRRIVRVRTFVVLRYWLLNHFMQDFYPSRDLRTTLTSWLNESAREERFRSSPRDLRLIKALKRTVRKCKEAYISGRAQRDAAAAGRSPVLGTAEDGGDEDRDVDLAVAPDRPPQQSLLSSGQDILAPSEPCADATAVDGGLKPPGPIARRLSDAMSTLGRIKRKLAAVSAKQTRRSAATIPSPEPSLRDGTEGSSADLLRHEDRLHSYLRQLGLELASKPNEENDESAAEISPSNVASECTPASIREAAIPPFDATAPAAVDGHVVHLGQASTSPATGLGILARDEELQPTGLDICGGPAFHTTPATETPSFSLLPGLFGPLVDSARPASVRVELDDLSDSSDDDDDDVIEAKRVMKRLPPARFLEAQTEQVSSADELRSRAVGVSTPEAASRTYSALFVDDEEGYEDGELVTVIPNFILDGLDDSDEENGEGGVEAALRRLEGIVDDARERRHAARVQQQMEKSSKLEEERRQREEGAAVLPSDDSTTTLASDAASPVESVDRDLLPAMHGALNTTRGPPELPTTTTEQSVVPRIDVELAAGRDAQAPSPGRANLTNRLFGQRATSAIATPRALSPQSLHRAFVMWHRTDVIVQHFTLIERDLLRMLSYQELVGGNWQRRPDKIDVLDWETYVKERRRLALAAAERGETTGSAVQDLLARFNLTANWVASEILLTASLDERVLVISKFIRLAFKSYCLHNLQTVMQFVHGLLHPDVARLHKTWGRVPAWEMRKLDSMKDLCGQTGSFGLLSAHMRAAALGRASQQLHKASFAPGNTGGSQACLPFVGLLLHDVSRTAELPTLLDPTAPDTAASVDSSGRLLAPAQPAAFDDHPPLPASTPLAPLVNVHQFRRLAETVRTLQTFQELSKQYTFKPVSAIYLRCLKLRVLDGHILHELSLRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4K3</accession>
    <name>A0A2S5B4K3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="741276.A0A2S5B4K3"/>
    <dbReference type="OrthoDB" id="2595549at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="478" mass="50661" checksum="1F1FB9432431730E" modified="2018-07-18" version="1">MLSAEEQHILELLRAIPPLLPPDLTCSPPTSPRPAQNGSTGSQKRKRTSSEAGTSNGRVMGLGIAVDGHDGAGLEDGSRRPVPPLASTSRAPPPPPPPANSAKPVSSSEPRESPRLTTPRLQPSGGGRDSPAVGTARNERIEAEWRTEWPRDRLRKLAAKCRDHGRKLKHAGDALARASTSHSRQTTLLAMAHHIDSILLYVFSFWCDDTANKNCNVQQWASVYGLVAFVKKQAQQENVPVVLGLCYRMEALAVFTTSMHEQKALHHKATQLLHGASASASALQTPRAPPPPPLPSGPPPPPPPPPPPSSSSAAAGAPQNAGSPASLSASTGSSHPTSPAPNAPPALRNGSHPPPPPPLLAASNKATEDALRGFVKASPDLFRFQRLYDASCSTLSPFLLSTFYPRTWSLSTTAPSGSNGQVVLAAFVLPNKPWRFAWPAELGRGTLGHQIAWARALVEEWAEAEGLEYEIGNVGEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4L0</accession>
    <name>A0A2S5B4L0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4L0"/>
    <dbReference type="STRING" id="741276.A0A2S5B4L0"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.510">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF66">
        <property type="entry name" value="CARD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="151"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="549"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="842" mass="91054" checksum="61C4969D09302ABD" modified="2018-07-18" version="1">MRRIFGASQPGEASLARSDSVHSDEPLDRLASPVLDGHNHNNGTRGSDSARRWFSPSTARSSSHGHSQPQSPDSSAQPRASTDSAAAGSSGSFPDLDRLPFGRTLSPSASSTASLSRVANGDGLQQAGSPATSEAGARASQLNAGKDAMMVELLSGEAIMEAAHYQVLPWDERQAMKKEHAALVTRLTGLRRSVAVEARLQDSAAKLVRFSAPEEAQAPVSATAPPRPRVTRQQAEAQLTVAQQKLNAAEHALTQVSAREAELHAKLLAHTAGVLSLALRNRDSADADSNRSSSAARLSTNSHTFADHHASTSRAATAAADQERVRSLERDLSSETAKASTLEKRLADLERALDQTKQQARAELEGLRSELTRAQQATASTEEAATHRVGELENEVQHLRAELGCATSETDQLRGQLSAAAPSDAHRPDTCVLEQDLEHARGEVKQLNDELEEAQGELQSLKQVFDDRLRAAEETGARRAAEAGASAQNRHRDMTQALGDVLRRHRTRPILGPALREVPPFDDTSDRSDLADYLASTLDDHFDRISTHVSSLSDEISALSHERDSAETELEVLRSQADDAAAGRAALAAQEEDLAASRREHQIAQSELSEARNRLAELEKELDEVTGERAELQQLWQVLPTAADGATTFSVTSLVNRSRALVDEHRSLSARVGEYERGHQATQTASQEADAARIRELEERVELSSQKEVTMLERLNDLTESLEATRAERRKLESRLAPLEAEKARLETELAAARSPPATSKSLPAAPSTPTVGSTAGSGANEGEVQELRDQITDLEEELADSQKREQRTRASLLEELATVQSEVSALKTQLRQAQRKIGGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4N8</accession>
    <name>A0A2S5B4N8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyl transferase 64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4N8"/>
    <dbReference type="STRING" id="741276.A0A2S5B4N8"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF2">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015783177" description="Glycosyl transferase 64 domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="7">
        <location>
            <begin position="56"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="464" mass="53235" checksum="F3AA36D100CA2814" modified="2018-07-18" version="1">MHARAPTRLLVLVASCLAWFGSTTLAAISRPDSQVNGNTNRLTAQLNVPLDRSEGFTIMLATYRRDQNLPLLLKHLTTEPPPSLRQIVIIWQNIGVELPDFLSTRSLETYAASGVRISVRKSRKNSMNERFRPLVDWDEDVKTRVVMIMDDDIVLRRETLEWGYHEFVTANEYGSGRVVGFTGRDVEHKDGEWQYTLRPKETYSMVLSNAAWLRREWLKKYWEDSVEMQSLRDYVDKVFNCDDILINYIVSNVTGNPPLLLQPKTQLRIIGGDGMFARGSVAVAEDGTDIVDDVEDDKVTGIPTASHFEQRKLCLSHYFDHFSQFAPPEPRSPHFPLVKTRTTASQDVEDHSRWLFRDEPWEPLTGWKLAEPQFHSAPIDPHEGDVDLDLDGDDESDLDIDRMLDQLSEEEIEDLLRDLEEERHRDGGAEDDLEDLEVADGGLFDEEDDDDDGGWHRPIERDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4T4</accession>
    <name>A0A2S5B4T4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4T4"/>
    <dbReference type="STRING" id="741276.A0A2S5B4T4"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="49"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="157" mass="16564" checksum="24B21A3445C05DEC" modified="2018-07-18" version="1">MIAASLSQSGADRLDRAPALYARARAALIPSKTADMPAQYTPDPIVTPEEMQQAIAAPPHDPSMWAKFSRKFKEEPLVPLGCLATVAALLGASSALQKGNRTQFNQFLRYRVAAQGLTLIAALGGSVYYGAQRRAQRDADRAAKAAAAAAAPTQTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4T5</accession>
    <name>A0A2S5B4T5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4T5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4T5"/>
    <dbReference type="OrthoDB" id="2405700at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038910">
        <property type="entry name" value="Hua1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="320" mass="34327" checksum="43538AA16DDF523A" modified="2018-07-18" version="1">MPVAPPLPNRPTAVVDTAEPESEEPPPPYEPVPSGSGEQTLEYGPLRPFQDSVPAAPLPAPFQPPPGPPLPPRVSPQWTGPYSPAVSSPPPSFPFWNGSNLTPQQTGYRDPYVQPQNGASPYAPPTSAPPLPSRISASPGAAASPPPPLRRAPSGYKPQESATPGQPLLYQGKLLVYAPGKECWKCSNTGYKPFDPYTGFRGDDPNHPCKNCWKKYGRPYTSAMRIALENPTSPVPPNYQRPLRLLQTPADRPVAPNVIGTTSGMPYISRNPNTIVVRPGDPRIGGVLCRRCGGSGLMMGPFIFDEVNCDYCNGAGRVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B593</accession>
    <name>A0A2S5B593_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000064">
        <property type="protein sequence ID" value="POY71950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B593"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="94" mass="10185" checksum="B10D9B68AA052D11" modified="2018-07-18" version="1" fragment="single">MLAPRLALRSRALLTARPSPLARTAWRSYVTSPLTPDPNAKPAAADLPVKPAADNRPFGPPATEDETRGELGQVKMPDMKEPESGEIEAQQVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5D0</accession>
    <name>A0A2S5B5D0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000069">
        <property type="protein sequence ID" value="POY71921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5D0"/>
    <dbReference type="STRING" id="741276.A0A2S5B5D0"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="152"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="617"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="710" mass="75025" checksum="2C85079836AC2992" modified="2018-07-18" version="1">MAPATATLRRQAANGIEYLTVWIATDEQQDGPVWRDWPDDADPRHGGGGVFAPAPVGTTSNRTLAILVPILISSTILLLLLCFFTLLLLHRRRRGIELSDDGGPTNLEREDQVEGEGGLDGVEARWLQTVDEPTKMGYVRAKIWQTQYPPDSQPTEITLSQFLSIQEKGVSAWSFEPDYESNPALIVESRTEITFLADGAGMAPEEGGGCSVQSNLPVPKLNDVYYFECKMYEKATTTNVSVGLATKPYPSFRMPGVSRYSVGYHSQDGFKSHSFPFTATSYGPPLLEGDTLGVGYRPRTGTVFFTRNGKKLEDAYVGFNKRNVFPTIGADGPCSVHVNLGQAGFVFIEANVKKWGLAPMMGTLAPPPAYGSERGSILLESAATGSSAATAEAGPPLRAPRHRRTSSLNSHIQASSAAAAAAAALSSPTQPIRPSPLRHSHARQSSSASSRSGESSAVRRDRRDAIGSDDDEGGMMNPPTPGLLDISLQSMHRFPERIHEASEDEGDTGTPASEEADEEDNEDESASDAEERQRLLHTAQTATVPVSTESASARSMYAPGVAETILEDVLGRVRSAAAAGSASVAASIAPQQAALHAYLAQQRRAAQHLTLNDLLSRPGINASGRSSPSFGSGSGYEARTDEAVVSTPGVGGAPASSSLWGWLTSRSTGAQGGDAVQAAAGGDAASRAEQGRAAAPPSPRSPPPPFSPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5E2</accession>
    <name>A0A2S5B5E2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY72004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5E2"/>
    <dbReference type="OrthoDB" id="2596179at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="259" mass="28374" checksum="966D5E01718A4DAE" modified="2018-07-18" version="1">MHYAESAVSRRSGLQRKRNISRRLLASAASMIGATLRPSRAASRSLRNASTRSHAARPPPPLLAAAETTTSRPRPPPPKYIRFATVYPFVLLSIITSLALNLSVQRTARQVEGGRHSAQISVLEDILARLRAPANAARLLTAEEQEEIERELELVGLGRGRGKEVVSAEMSDKADKATSWKEVFLGKKGKGYEQEEDKTDWEAVFRQAEEADRIKDVQRAPQLVASNAAIPGPPALPVEQAPTPITPVPPPRTSRPLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5F6</accession>
    <name>A0A2S5B5F6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BMF94_5017</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14"/>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY72008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5F6"/>
    <dbReference type="STRING" id="741276.A0A2S5B5F6"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="18">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="17">
        <location>
            <begin position="173"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="POY72008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="398" mass="42094" checksum="7D40591DEFC952CD" modified="2018-07-18" version="1">MTRVGIALVGPGLVGRLVLDQLSSDALQPHFELVSVSNSRYTVLHARQCAHELSMHELCAALPSSRQSLNAADAASSEGLFSVLDLGPTQLVQALGKRAAEMKQHIILIDCTASSAYPSIYAQANSSGLSVVTPNKVAFSSAEQLYRSIVDAQNSGPSAGLCYFEAACGAGLPICTTIRDLVRTGDEIVKIEAVLSGTLSYIFNQYSVVASETAPARPFSEIVRDAHEHGHTEPHPAEDLSGRDVARKLAILARLSSPNAAATFDLVEGHSSIPTQSLIPDDLVSTSDPQAFVASLAAYDARFDRLRQEAAADSSVLRYVGVLDPKAGSIECGLRRFPPSHPFAALSGSHISFAIYTNRYSASPLVIQGPGYPVEVTAAAVVSDAIRVAERFGSSFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5I1</accession>
    <name>A0A2S5B5I1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5I1"/>
    <dbReference type="OrthoDB" id="2530304at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="893" mass="96442" checksum="AF18C0BD407772BF" modified="2018-07-18" version="1">MDLPWPAFHPGAGLLYPVHHGYSAQLVQLSDPAALEAGNAYALQAAYLSQASLAPIPSTSQSVATHRQPQYSRAGGSVRPFEPATYASGIPGSPAPDRTVIRGYDDFPLHAGPYEPYGTYPLSTPAEAYLPIAQLPPTLAANRPFQASHPSASAPRHSLNRPAHSDLRRASSSRGHSSENGSDSAKRRYSQYGPGSATPERGSVQLVQDAHGSASLKRVRARQVQQDEAVADPATTWNPVPRLAQFAPAVPLWPAEEAHSVDAHLWYSQQTGVPTGTGMKGRLSIPCQPMQDSKRLQDLPEPPHATSTQLGYNDGPPPALGDCVAVGNGRSSPPVPIFTPQLSSPASPGYQADSSANEDELASVVALASIRRALHSSRPPPLASKASKASHKARNGTTPLLCRPPDHGAEQFEEERVLRERGRVNSTQQKRVASIEVLATCVSSNCGRPLARLVLRSIPEAIASALDSGLTANDVVRFSLANGAEGCLCLACSGLTRSNGTVKAADQSDAEESGGYKATLSAAVDRLEQVSLDPVSTAAASSSRASDEPQTATDSIASWESLPLINEARLPAHLKTAALRCDICAYICGFGAAESAIQHHGEAEFTVEVICARCDALFKCCSDCGGGGGRLTPGRWRSKELFPEGRKTCQLSHARNPALGEVSIDVLPIESIPPDELAVLEAQTRSLYFNTRLAVIARPEYLISGDGLARTFDEVERVTVDHWNIFSNLLQEEVPPDRNIRRYLTMMYSTPRKRHSRKTVKKPRGSFEPLERVPFGFAISEADYRDSTLCFCVVMPWPINGQAFDAVSMMGELTTQRAKLDLRALNQQRVLANPPLPRMPPLRYNYTLSPFRVGSHGNATLSRRGFEPLEDLARRDPQVDLSHFPPIKAMLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5P1</accession>
    <name>A0A2S5B5P1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial succinate-fumarate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5P1"/>
    <dbReference type="STRING" id="741276.A0A2S5B5P1"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="217"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34364" checksum="8428CE35E0E80E7E" modified="2018-07-18" version="1">MASKPATQKKTPIGVHLLAGGGAGLAEALVCHPLDTIKVRMQLSRSGKKAGTKARGFIATGAHIISKESPLGLYKGLGAVVTGITPKMAIRFASFEQYKALLANKETGKTGSSGIFFAGLGAGVTEAVLVVCPMEVVKIRLQAQVHSMTDPLDVPKYRNAAHALWLILREEGPGTLYRGVALTALRQATNQAANFTAYTELKRLLQHYQPQYPDGALPAYQTSLIGLISGAVGPFTNAPIDTIKTRIQRATALKGETAWTRFSTVAGQMFREEGPSAFYKGITPRVARVAPGQAVVFTVYERIKRFIEKPEDVKHEYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5Y9</accession>
    <name>A0A2S5B5Y9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5Y9"/>
    <dbReference type="STRING" id="741276.A0A2S5B5Y9"/>
    <dbReference type="OrthoDB" id="5415522at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="332" mass="36183" checksum="882897120BC2174F" modified="2018-07-18" version="1">MAVEAHADEKAVAQYSEPPSAEEAQAALPEVPLVPCSDYRCQRLVNRAGDEFCNDYPRAASYHYHNADGSFYQKLANGYSYYNDGKGYNRIELNGVFVREYTIDRTRPIPRDESDESSVAPSTPPRVKPDPYPTPPPTGEQAPRVVKAENEDADDCLARSSASPPASLNAVKRRSRSPDADRGEHAAGPPQRAGLAFATPEPTPGLAVPNTLFNSPPASPEKPPATSEQTSRTLARGTPHEDGRRTNAELLMTPRRSERIQDNHGKSYNVSSSGSNNQGNHYCSRDYGNGSNSHENSNGSYYYSNSNGSTYYNNGKGPATYTSANGKSWTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B662</accession>
    <name>A0A2S5B662_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cyn1</name>
        <name evidence="5" type="ORF">BMF94_4731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B662"/>
    <dbReference type="STRING" id="741276.A0A2S5B662"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="4">
        <location>
            <begin position="64"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="138" mass="15786" checksum="1A06BC152DC841FC" modified="2018-07-18" version="1">MTFEQIAQKLGRDEIWVAALFYGQASPLDDAKPTKEEVQKLGSVLDMSSLDDHFHEHWYPDRGQLGPMPPQDPTLYRLYEIVGVYGYAIKSCIHEKFGDGIMSAINFSAKVEKIQKKGADTVRITYEGKWLPYDFHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B671</accession>
    <name>A0A2S5B671_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B671"/>
    <dbReference type="STRING" id="741276.A0A2S5B671"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="225" mass="23397" checksum="8FBC5D2836EB96B9" modified="2018-07-18" version="1">MGVPEDNRPLPDGWTKQWDDNYKAYFYVDTRASPPRSIWTHPADEKPAQSYAPPPGPPPPRGATSPAFGGTSSQPPPYGAQDSRGPQGYGAAPAAPAAQQYYPQQGYGQPPMQGYGQPPMQGYGQPPMQGYGQPPMQGGYMPQQQPMYGQPMQQQSRFGGFGGRQGGGGMGAGGAAALGLGGGLLGGMLIGDMINSGQQDAYQDGFQDAQQDDGGGFDGGDGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6M5</accession>
    <name>A0A2S5B6M5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_4260</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6M5"/>
    <dbReference type="STRING" id="741276.A0A2S5B6M5"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015597502" description="ABC transporter domain-containing protein" evidence="15">
        <location>
            <begin position="25"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="892"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="934"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1000"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1089"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="438"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="712"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="730"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY72434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="121258" checksum="2A761C940E613326" modified="2018-07-18" version="1">MRPLQLGWAATALLSTSLASNSLAQVLQESNSAPKAAVWPDRPAIADSSLPPHLNSTTGRRRIQAYQHQLAAPALFADASAYGERPPECPPCNPFNCVLPAFPCLNTGKCNDYNGQCICQPGFGGEDCSKPLCGSLADGHERYPREGDQCECQEGWTGLNCNVCETDESCEDLITRDSPPSLRGGGSTPDDDLDRPVCYKEGFGVKEMYQMCDVTNRKILDMLPDRPPQVTFTCDIPSETCGFQFWIGRVESFYCGLSNCTASRDVQYGSNTTEYKCDKVECACIPGRMLCGENGSVDITDFLAEEIKGPGKFTTKTGEASKFEEPAMNQLINDIFGDTYITLKCNSGECMRRGSVPGFMPPRKPSSIVWLGVSIISVVAVLILGLFLFWYFGRGSSTAEYSFLGGRIRLPTNGHGPNGGAAAVSGKSLLEDHIPTALQFSDLSYTLTSGKRVLDGISGAVQPGEIMAVLGASGAGKSTFLDLLARKAKRGSVQGDILVNGRTVSSTEYRRVVGFVDQEDTLMGTLTVYETVLYSALLRLPRDMSFEDKRLRTLETMHELGILGIRNSRVGESGARGISGGEKRRVSIACELVTSPSILFLDEPTSGLDSYNAFNVIEALVQLARTYKRTVVFTIHQPQSNIVALFDKLILLARGKVVYSGRADESQAYFQKIGCDCPPGFNIADYLIDLTMQNEKSGQSDATVADALNQLEHRNGSPNGRGRNGNDPELGGPSSGSTTAASDSDLDERRTEPDTPTRGGHGLKQFLPSAVSGQATSHESSLSPELARLVAAFSTSSISEATRKEISQAKAAGATRGAGGGTDPRDLSLRNYKRASPWSQFKILSGRSFKNLYRDPMLMLSHYAVAVIAAGICAFLFRGLTEDIPGFQNRMGMIFFSLALFGFGCLTTLSTFASERLLFTRERANGYYNPATYFAAKLLFDIIPLRVIPAFLFGAIVYAPVGLVPEIVSFWRFILVLVLFNLTASSVVLLLSIVIKNAGVANLIGSLVMLFNLLFAGLLINRDKLPRWLRWLETFSFFHAAFEALLVNEVRYLQLKDHRYGVDIEVPAATILSMFGFNAQAFWFPDVTLLLACFGGFVVLSYVCLVVLVRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6W9</accession>
    <name>A0A2S5B6W9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6W9"/>
    <dbReference type="STRING" id="741276.A0A2S5B6W9"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="10">
        <location>
            <begin position="566"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="520"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="744" mass="80421" checksum="1B497882B0A3E23C" modified="2018-07-18" version="1">MASKGSKTEDTKTEHPFQAIVVCDGWGDEERWGPLVRRKKTEDEEYDDLEVGGEQRPWCLLPLLNVPLLAWTLESLSASGVEQAFLFVHDGVEHVRDWLASSSFMSPGAEMSITVRPTKAHTPGDVLREVDSLQILAPADYLVVQAGYVGNVNLKEKVDEFTSRRLQDPNLSMSCIVRPIAKQTHSTFAIHTLGANDQLLHYEQSSLYPGMRKFTVPREAFVGGAELQSRSDLEAVGAVICSSEVGPLFTENFDYQFFYPDFVNGLLTSDLLGKTICCTVLESDPASSAAGSRAPDWAFAVSNTKSYDAMSKAILARKAYPMAPDENMPNGSTRYEQRRARVYYGQDVDLSRTCKISSTSLIGSASRIGPNTYISHSVLGSSVQTGSSCQIVNSYVFEGAVLGDGCVVRDSVIGEGVRIAAGAVIEHGCLVAAGTVVGEGARLQGCRVSLEEYDGDEFDVHGSSLGRGAQGFLWPAEDQQAEEDDSDDEDAVDPRNLNVTRLGARSTRVRRVVSASSLSSLSRDGSDATLDSDDSMTDDDEGGYTSDAGPAIAGLDALQPESSGSGRKQSEFMTECIHSLDRSFAEGHTVDNASIELKTLRMASNVPLNEVRAVVVPYVLRRAGGAAGAADTLDRWGGLIASLTGDQDDAMVDCVLRAQEFVAAGDIDSGVAPGDVRMWLRVLKGFYENDVVSDDAVFAWYKSVDARKVGGDEGRKLWAASRPFLEAIQDDDDDEDDDSEDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B763</accession>
    <name>A0A2S5B763_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4452</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B763"/>
    <dbReference type="STRING" id="741276.A0A2S5B763"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000073">
        <property type="entry name" value="Probable 4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="499" mass="54557" checksum="1CA92C6127973D46" modified="2018-07-18" version="1">MLSATRRSLRFPARDLQRAARSFATEHNPPTRFESSSVFPDEPTHPTLKADSVPGPKSRQHSASIAEFQDPRAHVLVGDYVKSKGNYLVDVDGNEMLDVFAQIASIGIGYNNPELLALAKTDEFATAAMNRPALGSFPSEQWAETVHKGLLSVAPKGTPHLFTQMCGSCANEGALKAAFMAYRARERGQENQPQKFSEEELSSCMKNATPGTPDLVAMSFKSGFHGRLFGSLSLTRSKAIHKVDIPAFDWPAVPWPAIQYPLEEFAAENAEAESRAIAHVEETIKAQAKKGKKVAALIVEPVQSEGGDNHASPSFFKALRTLTKTGVGATGSFWAHEKWNLDSPPDFVTFSKKMQAAGFYHAADTRATDAYRGYNTWMGDPIRALQAREMISFIKAHGLVQHTAAIGDELYSALQGLGKKYSGQINRLRGKDCGTFIAWDAGSAEARDRFVAAMRQQGVVMGGCGEKAVRLRPMLVFGDKQLAIFLDKMETVLKQESGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B791</accession>
    <name>A0A2S5B791_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="741276.A0A2S5B791"/>
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    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="105"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="252"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="336"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="362"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="662" mass="71767" checksum="757677B940A2E1B6" modified="2018-07-18" version="1">MSTPASNAGSPPPGGFGGPRKRIRGAVDTSLILDGERSRKRTSNAVESAYTDPATVVSSDKLHAKGGSPHPNTLPAHDREGYERVRDLGIELYRKLINATDPKEPARPLFLAFAELPNPQEYPDYYKMLKKPISLKEIKEKLDTLQYRSFPDVRTDFNQVFVNAKRYNAPGSPIFVDAKRLHKVMREAYAVMTGEAEPPREEEPEAPEPVVIEQSAPPPDTAERGDDAKRATQLKPWLLKKLQEATHLYDGDGRRLADVFEKLPDRNMWPDYYQIIANPQSFSTVKYRVTHRYYATAASFIDDVNLIFANALYYNEESSGIAQDALRLRQHFAQVMREPPPPFIPPREPRKYTKREPKEAKQKRQASAAPTPQPVEQATADDHQDGSDAESEDEMSRRGSVAPEGNPGYGETGPADPYSLQPAYASTSTGVHNFGAAVAPNGLASAAGPVYGQGEVSPSFQNPALAGLAGSPSLANGTAARPGIYSTPSNEGPRVPRHIAKVPSGDEVPSVTRIDVAFSSPSASCPKSVVLDNSTIRQHSLSIPSGTERVEIAFRVQRGGKGKAKAENGLTASDDPVPQISAATRPETLELAEVTEATTNAGAMMTNGADLSVASADGSDGAVKRKYVFKPRVGLNVFEVLIKAPGAADGDAEEVFRVFVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7D7</accession>
    <name>A0A2S5B7D7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7D7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7D7"/>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
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            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="509" mass="51494" checksum="0A1385340BAAB22E" modified="2018-07-18" version="1">MSNDENNLVLQLTGRLEQLQREKDQLERAVEGQGDAIALKLRLALLAYEQQKPIPQPRHSSKSRTGSSSSSVSTSASTSSSVSFPSSPSSSSLISPTLPAPDLTPDVLLALRENETLRVRLANSERVNAYYQRELAELRRRCGISIDELEELDLSPGFSGAGTSFPRQRSLSRPSRLDAYGGPSSSSIRIPGAATSVSPPGGRSANGGGTGGGGGRRSLASSFMFSPDGARSARFASNSYTSSINTTATTPSSSYPNPRPPAATPATNAAFSPASANANLSLGGAGLGFGSPFINGLATSVGSGGSHDITQRRSSLNGLVAAHFAASSLQSDASGGGGGGPSHGGYPGGVGIDLDDLVSLGGGSAGDRGSSSSRSVSSESRSRVTIVPPTTTGSAERQRGLLPRATGTGIGVTEGALAGLTSSGTSDGGRPTAADPVDPLVAAITRGLAKLVAEGTATLVDESDGDEGLSPISPMAAGRLEEEDGDGAETPLSNVASRTGSILRRRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7R9</accession>
    <name>A0A2S5B7R9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7R9"/>
    <dbReference type="STRING" id="741276.A0A2S5B7R9"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="2">
        <location>
            <begin position="69"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="3">
        <location>
            <begin position="201"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="738" mass="78111" checksum="A02A600C6D6EF9FF" modified="2018-07-18" version="1">MAALPSQGPPHLVQCDIATTLAVTLDPTRERRPTSPRLAGTPPQSASQLDRHSASDSQGRHNGSPTPPSNVYLGETYAAQITLSVPREAAPHTAHKVNLVVEIHSGIPPLVDPAAAAPPPPSQPPPSQIRQHSITKRDYDRIEPGQAVRVPIEWELKELASHAVVCFVSYGVQVQDRETGEPTLVTRQLRKILRFEVLNPLSVRTKAHAPTPQSPTTYFSSTERCKVFLEVQVQNHCDSPMSFSRMRFDALPGFTVSDDANRGFLVGDGGGASATVRDGKADDFLHLPTGSVRQFLYILTIADPALLGSALPPGSSQGLGRLDIVWHTERGQKGHLQSATLGRRIPPASAHVIQGPGSNTAAGRQVGASPALPPLPPASSTRASASRPSPSPQRGFDHSLTPAAATSASTPRTSISSVSAAQAAGYLDPGTSLPEGCRVDVTVSDVLPAGTACRVDEPVTVRLRLAVQRPRVVRAKEPVQCAEGAKAPQQPRRVRLVAQHVQWYLSPTLRGGAHRPPLEDKSLSTPVSARRNARSTEMAIPGAMPPSGATPASQQQPGLTSLELQQRRAALLTGHRRAVSFDPSATVAGSAAEALHSGDDDDSQWRGAPRMHGVRLPKPVPDSGSPALGATGSSGPSVAVMRLGTDTVDLGWVDIPGAEGGEEKEDDRPSIETAVHFELRFVPLERGLVRFGGLRVLALPADGGAMASAAERAEDEPRDLPVAVAVWEAATIAEVWCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7X1</accession>
    <name>A0A2S5B7X1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7X1"/>
    <dbReference type="STRING" id="741276.A0A2S5B7X1"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000191">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000534">
        <property type="entry name" value="Serine/threonine-protein kinase PKH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="479"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="194"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="768"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="889"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1009"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="795"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="908"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1030"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1175" mass="125409" checksum="4597C94397272F91" modified="2018-07-18" version="1">MSASISGGFPLRSPTSNKKGSSSSGRRRPSVTSGMSVSSPDVPQLHSMPTRAQSPQTHPPQASEQAQQSSRPHHHHHGLSLHPLTPLNAPTSMSSHSSSSSNGGNERSSSLTGATPGPSASSLSLTSIDSASTTFTTATGVSRASSTRSTSSVQAVPMRKPQRGPAVPRIVTRGMNALSAYGVGMATAGAGTAPPPLSPTWEKGGVKPVGSSPADFPGLVASTSRTLSAEGDGAGPSEGTTLRPNMLQRASWRRRVGSGGSSSAAGTIAAEFRAAGGRPSPVNEDGSAPSSPDHRPSTPSGSLAPGEEIPIPGPGSGARAPLEPWKVLERPGDETGSLIGNRNARPRRLQPSGDSSPSSNGSKSPGSPASWERPRYERAESSKFDDAIRLRQRNASNDTATNGDRDASLSPVRGMAARGRSRPYGNGHERNSSTATTSTATATSPVRSRDRELQQQQALIGMTPNAMGVVGNRRSTEDFEIGDVLGEGSYSTVTLATTVHPPYRQYALKVLDKEHIKRERKTKYVLIERDTLKTLDGHPGVIKLWWTFQDEWSLYYVLEYAENGELLKWIKKYGSFDLRSARYYVAQILSAVEYMHEKGVIHRDLKPENILLDRNMRVKITDFGTAKLLRQDEIKDGQPAPAEVQPGGRPRARSFVGTPEYVSPEILSEGRESSFSSDFWALGCVLYQVLAGHPPFQARTEYLTFQKIINLQYDFPPGFPAHARDLVEKLLVVDPLARLGGDPANGNGIEAIKSHPFFTERLRPTRSSLSEAGAQDLPSPLLFTPPPSDADLHTLDSTSDTLSSSFSELKLGSPLPHSREPSRSHLDDPVDWARIWDVEPPQIETGLCPPVPTMKGQFILLDDGQSSLAPSTTRTGLDSLHLESEAVGDDLAASRRSPAPTPAVTTPDVDEDGIAYPDEDDEDDDELDDLEAVAGSPTSASGRDLPPASTFGTSKWSDVLLPSETIIMLSPILQRPSSSAAAARTAILGRGQRIKSLNPLNLIASSSLTTASSPNGSPQGQLVPLPGTTPPTSVSMSASSTLTGVTSGPSIASSGTFAGSTSPLPSPPLMPASGYKARTLILTDYPRLICIKETPERISVKSEVFLGATTRTMPRREGVSAFVAVEPSSKDPNLFTVKTTSRNFKYEEPFGHAARWIRELREAHHSALAPTQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B841</accession>
    <name>A0A2S5B841_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4003</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B841"/>
    <dbReference type="STRING" id="741276.A0A2S5B841"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="294"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="11">
        <location>
            <begin position="446"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="85419" checksum="0E81DBAF2E2CF304" modified="2018-07-18" version="1">MPLVPSLQQVLDTLLSSLYNLQTAVAGGQKRYYSAIFRDLPDRRLYPDYYHVIREPRCLHDVMNNMHRGLYSSPQAVAYDLFLIWSNAREYNEQGSLVYADADKLEPAAPTGADREPERKVKRIKLTGSLAGGSTGSSVPTLDNLPPIASTSSVSSAAGTPTLKLKLGGPRPTPVAAPPPRANPSPAAAPVPEHSAPAPIAPTQPDLVVGPVADIAVDSTASTSTASTTHPSAVAVTATSTVTGAGTGDDETKPAAASTVPTIADVESGWLDGPADAERLANIANRLRTYTDASGRVLATPLVDVPEPASRPDYYKLVTNPISLNVIEERIRAGFYTSAEAFDRDLHRLFEVAKLFIRPDATGTAYSDLMVLQRLYQELTKNDSSADRSVESASAASLASVSGGPGNVLHSKGEDGAQGSDYKNRATTRPTTRDKIFLDGIHFKGQTLRTGDWVHLLNPDSPGKPIIAQIWKTYKKPDSTQRCLSVCWYYRPEETVHPVTRTFYENEVFKTGVFVDHNIEDFLGSCFVMFFTRYTRGRPKAWDPSMPLYVCEHRYKDEAKQFKKIKSWSSCIPEEIRAHEYDFEPYADNHVDQLTRVKSPFTRGVPGPGRLDSAQANVVPSASPAYHFSTDGKPQTAEEANFDISVTPLEPPSAALLGVAAAPPPSVVAPSVPATVAPPPAAATAPPAVHVEHLAPPASVPALPQIAGTTFDVATGSLGSLQAFNVPAGSTPAELAASKEACSPIPGYLKSKFRGDTFGELLWFSAPAATVPPVKRPAHSLAYLLWQTEQRHSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8K4</accession>
    <name>A0A2S5B8K4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3846</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000041">
        <property type="protein sequence ID" value="POY73108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8K4"/>
    <dbReference type="STRING" id="741276.A0A2S5B8K4"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.40:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="64" mass="7221" checksum="432D8841CCD94850" modified="2018-07-18" version="1">MHLMYSPGPDGKRQYTLKKATSSGVPTRSAHPARFSPDDKYSRHRVTIKKRFGILLTQRPAPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8N1</accession>
    <name>A0A2S5B8N1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B8N1"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43670">
        <property type="entry name" value="HEAT SHOCK PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43670:SF131">
        <property type="entry name" value="LRRGT00202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="6">
        <location>
            <begin position="48"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="676"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="798"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1432"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1759"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1840"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1919"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2061"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2156"/>
            <end position="2225"/>
        </location>
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    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1603"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1656"/>
            <end position="1690"/>
        </location>
    </feature>
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        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
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        <location>
            <begin position="704"/>
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    </feature>
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        <location>
            <begin position="741"/>
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            <begin position="1451"/>
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        <location>
            <begin position="1978"/>
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        </location>
    </feature>
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        <location>
            <begin position="2005"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="2016"/>
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        </location>
    </feature>
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            <begin position="2039"/>
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    </feature>
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        <location>
            <begin position="2103"/>
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        </location>
    </feature>
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        <location>
            <begin position="2121"/>
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        </location>
    </feature>
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        <location>
            <begin position="2181"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2202"/>
            <end position="2215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2225" mass="225123" checksum="3707ABFED3C07CDE" modified="2018-07-18" version="1">MSAHASTMEAPEEDTEFLTLTQPVKGVTLRLSDTFYDQETPCTAEPGHLLAVSNHFGWVVAANSQRGFGLFSLPALRSAVEAATPHDTPRVEPKLAVPTTAPVDVLRFAMADKLVLAGLRDGTVVVWRLKSLVEGQSEPLRTLPATAPGTALVDLCPNPAPDSPLLAVLSPAAPLTIYNLETASVHGTFPADLGATSACWSVKGKQLAVGTASAAIVQLTPEGEQKAVVPPPTNELAPLGGTFEVRSVEWLENNVFLATYARPRTATEHDVQHEDEVFAITKVGSEVQYTKFADPCPPFGMMGRQGRRWVGRFKNWEPFKHLLVMVNAPSADIGVLAQAAAYSPTSTSNGWATLTLPEDTRPTMPTGDLGDDACPLALELDLSGPNEPAVLVYTSRGALVYWTFKNERATGRYEGMVESRDVVTQEGEAQSAVPAASPATPSAFGAFASPSTSAPAAPAFGSASTAPAFGAKPAFGTTAAPAFGSTSAFGSSASKPAFGATSSPFGSASTPTAFGAASPSAAPAFGSTSSLGFGAFGSSSPAAKPAISSPFATAATSTASTPAAGSAFAAVPSTGGFSAFGSGSTGGFGAAAGTSSASKASPFGSGSAFGAAPAFGASASSATTTKPASSAVGGGFASFGAATGSTASPPGGFGGFGGSKTKSVFGAPSDLGTSAFGSGGTAPASGASKFSFAPTASRGGRGSDDEDEDEESMVDEAKERADEPPDLEPTKVGLDFAQSVREAEKAGPPKRENASAAATSSMSGSDALSGGFGSLGFGGGGVKATSEEAKPATMSVFGSAAAASTTPAASTATKPAFGFGATTSPSPFGGSSFGFGAQAKKDDSAASKPASAFGAGGFAGFASASTTPKDTSQSKPTFSFAPKPAEPPKEDPTAAGKNADAPVSPAATSQAESKPAAFSFAPPGSDAKKEEEKKPAGSAFSFGGTAPSGGLNSENSTPAKEEEKDGEPAKSEKVDASPAPSPPKDDEAEDDEGPDVSQDQDREQEQEQTQDDEEEEEEDEQEPSLEASSEDGSESNASGAVEVSPAEPAAPSKPAFSFASSSTPAFPKPAASGGFGAFSSGTSSGFGFGAAASGKTPSSTGFGFGVVTTPSPSAAGSTGFSFAPKATAPADAASKPAFSFAPQTPQVEKSTKPTENPTEKPAFSFAPKPASGPVPIPAAEEKSKDSTKSLFGFASSPPAEKSPSCGGNSLLSRIGAKEAASDDEHSAEEEEDEEDEEDEEDEEEEEEEEEEEEEDEEQEEEDEHGDHDGKQSGEASEDETAATPSGQPSLLSRLSPAPASPSPAPEAKPAATTTPSFSFAPAKPSPPASAPASEASPKPPTFSFATPPGTSSAQSAPTSPAPIVTSNLGSTSPFGAPKSPGGFLNFTSTAPRASSPLSAPPFAAQAAAPLVPKGTSPAPSPGLFGASAAQPAFSFGNVSTPPTSLAGAKPSPAPVSPVPVSPVPPTPVLGKKASPVPTATPPPPVPEPEVPKALSVVSTPVQKLGSQLIAAGAASAPAVSEKGMAGEFLKAYLSVQQDFELLRKNSATIKDFVDGLGRPCHAPLSKGVRPSLEPKDWSFGDVDKLKQLTEDAAPGVETLHAAALAQKRRIAELQSQLLKAETKREEAARFLRARSDPAFAKLVRVRQLGPEQTENQRRIRLQVEAVRTKVEQLEEHLLSLKKQIAREKLGQPTLQAPSLDSIQRAMRNISVAAAEKSFELDELASKLDKLRVRTGSSPTTPRKQQSFGMSPLKAALDQSSLFRQSSPASPHAAVSPPGPAASEMAATALVQERVAGNLKKALLSLRTSAPLVNRSACGSQTAQLKRPAAADIQLAFAHGPITGDRLPRPRHHTPPALPQMVAPTPTKSLEQRSMPAPSAVSAPIPSSTPSFGLDTPASKVAPPIFPSLDLKAAPSFSFASPVAASPPPSSSSQPGVTASRGSASRHTSSRVHGGAVQLKSTGTPPPPAASTFDWGPLPSSTSTPAKTGNFISLAATPSTAPPAPAAASAKPSFTSMTAGSSTPSATPVKGPSGFSFGNTSTPATPPAAAKGLPTFSFAGVSTTPSATPSKPPASFSFATSTPAASPAPTTFGFSGASIEAASTKPSSFPFGTSTPTAKAPSSFSFGGVTSTTPAAKPSFNFGGGLTAEAPAAALASKATGDITPKAAAGSEDEDQKQQDGNEGEETWSGDEEDYGDEKYGESGDEEEDEEDEEGLEAISEHTEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8W3</accession>
    <name>A0A2S5B8W3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8W3"/>
    <dbReference type="STRING" id="741276.A0A2S5B8W3"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="3">
        <location>
            <begin position="211"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
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            <begin position="260"/>
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            <begin position="436"/>
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    </feature>
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        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
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        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
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        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="586" mass="63584" checksum="2AFC69C8750AE46E" modified="2018-07-18" version="1">MHRAIARAAAAGSIRAARGPSARAHSAVVAAAPRVGSCRCYTAPPDQAGPAETTLTYSLPQDAFDSLPDLDSPPSDAPSPLAGPSTPRASIRAETPQARRRQRQTLSNAEAQAFADLLGEIMPRSAAQPASSAATPGSTESGLFGMFSSAGAASADSTAGAGTSLEGGVSKVHQALMRKVGHKIGIQLDPGSGRWARKARTELTEQEELELDRLREELVGLKSDHEVLKWGLENVFGYSVDGTKGTMLFPDPETLPVEIPSTAATPGATGSAAVSRSPQRGPSSRMYPDLLLLLFVVLRDTHRNPTGALSLFHLAKSNPFSYINGCTTALYLEVLRTSWADGAGDVEAVLAALDEMRANGVPFDDKVRELVRAIGEAIRIDQDRAELRLERDVQTRGLTFTSPDERERQVLVRRWFDSTQVGAWSRMERIVEENQDELEDARRAKEDERWQDSERARRDRFASEREQAYRDRPDLMPRPASSGPTAAGSPWDAPVPSAYTGGAAASSGRASLSSPRKPGLATGADGLESRPWETWKVPTMEHDADGNLVMPKRPSFVNPFKIRRKGLTKEEKARKDTKHPALWWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B939</accession>
    <name>A0A2S5B939_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B939"/>
    <dbReference type="STRING" id="741276.A0A2S5B939"/>
    <dbReference type="OrthoDB" id="2553651at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="303" mass="32743" checksum="7957C5D42B7B5A65" modified="2018-07-18" version="1">MSYAKVLAKDAPPEERQPHPDTSLLTKPADVAHGPTSPRSPVPDLTAEKANVVDREDFEKLRKGVEHADEPQPDAFAEAAQHQAEREQARLKSQAQAELKRTTDKVDAAAGEAAQKGQELASDAKATGKQAAADAKAAGKQVASDAKATGKQVANDASKALDEGKKQAAETYREGKKEAEQLYSQGKKNAQEIYSEGKKEAKDIAGKIEREGKAEAKKLQRKASELEREGRDLAKRYPVAASGLIGLTNAILIAVPAYYAYTNWHYPRWDKRIVSAVAVGLGAIFSAEGALGWFEYKQEHPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B953</accession>
    <name>A0A2S5B953_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B953"/>
    <dbReference type="STRING" id="741276.A0A2S5B953"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="771"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="936"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="947"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1032" mass="109715" checksum="CB111011C98FA7FB" modified="2018-07-18" version="1">MDFELAGDDPAFDQPSPSTASVASPAPHFATSGPLTNGAAARRRKALPVHRCRFPDWNPSSVTALAITPDSFDAGSLGLGGHSGERGVLAVGRANGDVELMVWGGQQGWISWRTLPSAFPLPKERNSRKPTTLLSHLVFTHQTTLSETDLDLYEGDVEGADREIRRLQREGVRLFGVGGVGSELVEWDWGGPGSGRAVGMVKSTLPTLPPIFAVAASRSSSSLAIACEDSTLRILNIMDGELELVSKIEVGGPGKVRALSLAWGPPVAPKSSKGKERDDSPDPESKLPAHYVTPAETYLVAGCSNSTIRRFDVPASGSVVGIWRGGPRMTLDRLKGEHTVVWAVAVLGNGTVVSGDSMGNVKFWDAKMGTQTQSFRAHKADVLALALGSDGTSIFTSGVDQKTVEFRQVTVASSRVHDVPVGRWIQASGRRLHAHDVRAIVISPAFALPLPTPPPSTAMRKSLVPIMVSAGLDLSLILTPVSSATTASAKKRTLPNPVSDAPSTEFESTIHRRAAYVPQRARPFNVASGSDTPRLLVCRRDRGVGIWRLDDPKRAGSAHGAGANAAPLQKPRWGRSTFGVGLDGQSSDIAEEEEVGTTGYEKVAELDLKLQTNLTASAVSTDGRWLAVSDLYETKLFRLTWKNGELVPRRQKSFADALASGLTSVSLGTGAACLAFTRDSQRLVLSTAFTASTLVVQMPATRGDDCEVVAAFGPGVTRVAKAANGFAHGGEDTEMNGTGADSGDESSSSEDEAAATADTKTQRIQSSTACLAVSPDGAYVATAETDRTVRIFDVASSSLHATLPAPPMVPAWLSFASSSASTEPTLIVALPSNALLLYGLKSKRFHPWALPLSSRRYNTLMDIREPVLGVTFEPSRPESTVSSPVANDEHVHPSRRVAVQTGATESSVAVVWGANWVAKIDLEALRRSGGSSALVNGFKSKGAQKGGPERREADRKRAREDDDDLVASANGNATGSKADEPKPLDIRVTRRYQPLVLFDFVGQGELVAVERTWFDVARDLPQAWQKAGQFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9M5</accession>
    <name>A0A2S5B9M5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9M5"/>
    <dbReference type="OrthoDB" id="10435136at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="451" mass="49341" checksum="B16A8E097A276300" modified="2018-07-18" version="1">MPAVLPRQFSSSAVSSPTLTSTRIEPLADSFATRFIPSPTASTTSSADSSSSSTVIDVWQYLILAFVVFLAGCLIGTVFIFRNKAKAARARRAARIAAEAEATSRSDADDDGSTRRSSFASSRRESEYALEDGEGDELSMVEIRSTRSGVLAPPAYRERPRTAETATSATVSTSTSADGTPKPRTLSSRLSRIPSAIGSFLSKRVQPGLGGNNVSTDELQTRAAEAQLEAARNSRNSSRRASTSSSMFAFSPRRTSSSPAVYPPPSPSRRSRLQSEPPSAETVDQVRQIRRALSDAGLLFAPPRSLSDRRLSGVSSSRPAVLATMHEDRQRQDDADEEAEREIYRQERRARRRRRRERERQRLEDEAGLPTYSREAADGDVVLQRADGWKSEEEDDEAEEETALDALEDAMRARDRQAEPIQALAGRSTGRTSASTEPTPSVHIEERRTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9N2</accession>
    <name>A0A2S5B9N2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9N2"/>
    <dbReference type="STRING" id="741276.A0A2S5B9N2"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36213" checksum="6E78223BEFB93E00" modified="2018-07-18" version="1">MSAQLSTDAQVNSQVPSATRADRLMSSFSAFRTELDQHQAQRERIVKLSRDVTALSKQLIFALHRIASGKGIQTVVREAEGKMKDLRVLFAKLQGEVQGADFWRYERSVSPGIQEYLEGFTFYYYLQHHSLPTLEEAQASLIPPPTPPPPASEAPAAGASSSAANDASISAAVPTEQTEDARPPISDSAEQEPREPYFRVTIDDYLGGVADLTGELMRLAIASVGKNLSASLAGQSGGGGDEGGGDFADIDRIGKLVREIKGEMDPLAIYARWLPKKLTVLDQSLAKIENASYNLRIRGAEYKDSPAMLQALARKMAESGGASERRGGGDEIEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9S0</accession>
    <name>A0A2S5B9S0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_3453</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B9S0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000373">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000013">
        <property type="entry name" value="Dynein heavy chain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1962"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2644"/>
            <end position="2799"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2986"/>
            <end position="3152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="997"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3481"/>
            <end position="3529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="997"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY73516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="4685" mass="522747" checksum="C635AF946C702DE2" modified="2018-07-18" version="1">[encoded data, 4685 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9T8</accession>
    <name>A0A2S5B9T8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9T8"/>
    <dbReference type="STRING" id="741276.A0A2S5B9T8"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="62271" checksum="BEA69C2AD19C0EFB" modified="2018-07-18" version="1">MADSRSLSSSDGEKLPVHHNQPQGGQVKDKATEDHLEHYVDQTTARGGFSSTLAAVQEAHGFKAEAGRLVVDPEEAKIEYGEEVASRLKRNKRGNKILWPQPSDDPNDPQNWSTRKKNIQLIALTMASFTPDFNSGLGIASLFALAKEFNTTTTVINNLTSNWSIFLLGWGGICSVPLMKRYGRLPVLWWSQVLGLGFLIGCAVAPNLSTFAAMRCLTAFFSTAPQCVGLWTISDMFPFHLQARKTTLWAMGFIISPFLSPFLLGYMIEHTSWRNVYWVGVGYTAVVVLVLTFVMEETMYDRHLSPVPPRHATGVRYRFDTLIGITGARMAKYRPSLWAGIASLFDVLWRPHALMVYIYVGWIFGCGIGINVTNAVFIGSPPPLGYGYKPVVEASLYATPIVAVILGEIAGRVSNDAIANRLIRRNSGVFLAEMRLWSNYIGMPFFFAGMILLGFAYEKKLNLAAVILGWGMAEFGIVLITVACYNYLGNTFPQQQGETSALINLARVLGGFASSDRAGKGEVPWSIANGTERVFGMEAGVGVGLLLVLIIPLQIFGRRIRNKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA27</accession>
    <name>A0A2S5BA27_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA27"/>
    <dbReference type="OrthoDB" id="2529341at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38852" checksum="FF6D669A900C7789" modified="2018-07-18" version="1">MLVSQPPPISLLPPELLFRILELAVEGLPATFRMRASILRQFALVARDWREPAQALLESRVHIDSYHRARAFLDRPRRLGRRLVFDELVFFFDFAPEEEGFYPLTEFMTQSICHLDCEVRFLHLRSALYLDCFDLRLLLLPAFRELRHLRLDMPLESPADLDVLPFRLRALTLSGMVDQPLSLFKAVLPDGGTSLTSLSIFVVQSGGWLHERLLVAAPSLTSTLRRVAIATHWAPLPGSLLAFLASCRALASLTLSGVPLAQVEHLIEATSSPLEALDFSLPKTPSRAGSIGTLFERLLSHSGARHLRYLTAIRRLEGGTGEKLERVAVQRGGCVCVYETTTRRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA91</accession>
    <name>A0A2S5BA91_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA91"/>
    <dbReference type="STRING" id="741276.A0A2S5BA91"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF243">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="567" mass="59086" checksum="E3521DB031D06613" modified="2018-07-18" version="1">MTRYFCHECSHEGDNFATNQEGFVCPNCGGSFCEEIPNNDGMADDPREFDPIDDEEENSFGFFGSPNANRPTFVNPGRRNTESGHATGAGAARRNGNFFHYESPGGGFVFTAGAAGLGGPAAGPVNPLAHSLLQAFGLAPPAQGPYAAATPAGHEDGPSGRPQARRWQSAGANDPANRQQQQQVPIQNLATFLNDAFGGPHPADDPSNNPFAEGSHEAGAEAERAPQYDVRQDGPAQHPLGALFSLFGNVFGAAPLHGNAGDYAWGSEANFQQLLNDLMEQVHRAAGRAGPQPAPDDMIEKLPRLKVDQKILDMDSVTTCGVCLDAFQLGDGAVALPCKHFYHEDCLVPWLKTSGTCPICRYALVPQPGQPGYGEEDQQQPQTSPGSTGPAATGSSTSTSGPGPSGPSTSIGAGSAPQPPLSTRPSTSQIPDVEGGSTLPGSWVWPASDSDSQSPRSPDRRTSTVQNSLTEEEQDPEETPLPSEPSAVSTATIPSHDGVGGGGADQARSAAQAAADAAERRRAAEADERKRRQAVPVQPAEAAGGYAHAASSSSQTHDEGLPIDDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAB4</accession>
    <name>A0A2S5BAB4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="28">Putative Shikimate dehydrogenase, or putative Shikimate kinase</fullName>
            <ecNumber evidence="28">1.1.1.25</ecNumber>
            <ecNumber evidence="28">2.7.1.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BMF94_3251</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="28"/>
    <dbReference type="EC" id="2.7.1.71" evidence="28"/>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BAB4"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 28" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 28" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="24">
        <location>
            <begin position="93"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="27">
        <location>
            <begin position="206"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Enolpyruvate transferase" evidence="22">
        <location>
            <begin position="429"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="25">
        <location>
            <begin position="1361"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="23">
        <location>
            <begin position="1476"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="26">
        <location>
            <begin position="1610"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="28">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="POY73713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1647" mass="178652" checksum="40612967D322C86D" modified="2018-07-18" version="1" fragment="single">ERFELTDTTIAPQARTETAVDKVAILGSESIHCGFHLIPYIVETVLTTLQSSTYVLFTDSHLAPLYLDEFASAFEKAIAQLPAESRPRWITNVIPPGEQSKSRRTKAELEDFLLSHRCTRDTVVLALGGGVIGDLVGFVAATFMRGIRFCQIPTTLLAMVDSAVGGKTAIDTPLGKNLIGAFHQPSYIFIDASFLESLPRREFVNGMAEVIKTAAIWDEHEFAKLESGVAEIHAAVTGASTRESFAGRTLESRSAAQSLLLSVIRASIATKAHIVTVDEKETGLRNLVNFGHTIGHAIEAVMTPEVLHGECVAVGMVLEAEVARSLGALGNAAVGRLTRCIKAHGLPVSVDDPLFRKSAKSARLNVETLLDIMRVDKKNSGNVKKIVLLSRIGKTFEERATGVKDDVIARVLAPAVRVFPGPPTNKVFELATPGSKSISNRALVLAALGNGTCKLGNLLHSDDTQVMMAALHEMRGAEFAWEDNGELLIVKGNGGKLSPPKDDKELYLGNAGTAARFLTTVCALVQPEGQQRHTVITGNARMKQRPIGPLVDALRSNGTSVDYLESEAALPLKIVATEQGFRGGKIQLAASVSSQYVSSILLCAPYAREEVVLELTGGVVISQPYIDMTIAMMKAFGITVERLSGEDGKLLDVYRIPRGTYSNPATYNIESDASSATYPLAMAAMTGTTCTIHNIGSASLQGDARFAKDVLEPMGCKVIQTESETTVTGPPVGQLRALGFVDMEPMTDAFLTASALAAVATLPPLEGRLQDAQQPLNSTRIGGIANQRVKECNRIDAMRTQLAKFGVETNELEDGIEVFGIKPEQLRPGVSVHCFDDHRVAMAFSVLAACPGAHGAVLEEKRCVEKTWPSWWDDLSRKIGVEVVGVELDDSPVASTSAAIPRHSTDASILVLGMRGAGKTHISRIGAASLGWPVLDADEMFVTEYGQSAKDFVNSRGGDWKEFRLAETQILKKIISEYGKGHVVSLGGGVVETEENRELLRAYGHGGGPIVHIIRDIDDIVSYLNSEPSRPSLGEDLHVIYQRRKPWFHELSNFELTNLITGKPKTVKAGKTATANGFVISHTTLKGAEDEVSRFFRFMTGFDTNHVQLLSERATYFLCLTLPSYTDSHPALDSFDELIAGVDALELRVDLLSADGKAPTAPQVPEYDYVARQLAALRQRSTLPIIFTVRTASQGGMCPDEAQEAIFELMKLGVKAGCEYVDMEVRWPSARIRDFVGIKQSTKIIASWHDFAGGLRWTSQEATDRYNAAHAVGDIVKIVSKANAVTDNLDMLRFREKHQDGKPLITLNIGNEGRLSRVLNPVFSPVSHPTISVSAPGQLSFAEVQQALHLLGKMPARKLYLFGSPIQHSKSPLIHNSAFQKLGLPYNYGLIETTEVNDAIKQAIRAPDFGGASVTIPLKLDIIPLLDEVSEHARLIGAVNTIVPVQEGEAVRLIGDNTDWLGLLELINQNVSSDNERTDTSTALVLGAGGTCRAAVYALHKAGFKTIYLFNRTRPNADKIVESFPREYNIIPLTSLDSFPGEHPLAIISTIPAQGTATHHVQNAEAGVVVPDSVLSREDGGVLIDVAYKPKVTPLIDLAERTSGWTGVPGIQMLLEQGFWQSSMWTSRRPPKELIRKVVMAEYDREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAD7</accession>
    <name>A0A2S5BAD7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAD7"/>
    <dbReference type="STRING" id="741276.A0A2S5BAD7"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="46"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="206" mass="22894" checksum="C2DEC98F3BC5772F" modified="2018-07-18" version="1">MSTFEHQPVPKDVLEANANGILLFNKWDASEVEVKDISLTDYIQVRNAVLLPHTAGRYATKQFRKAQMPIVERLVNSLMMNGRNNGKKQMAVRIVAHAFEIVNLLTDQNPIQVLVDAVVNTGPREDSTRIGSQGTVRRQAVDVSPLRRVNQAVALITIGVRESSFRNVKSISECLADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAG4</accession>
    <name>A0A2S5BAG4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3297</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAG4"/>
    <dbReference type="STRING" id="741276.A0A2S5BAG4"/>
    <dbReference type="OrthoDB" id="2530296at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF2">
        <property type="entry name" value="AGAP013096-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="590"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="108"/>
            <end position="117"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="125"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="244"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="281"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="490"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="602"/>
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        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="721"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="778"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="805"/>
            <end position="818"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="822"/>
            <end position="833"/>
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    </feature>
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        <location>
            <begin position="834"/>
            <end position="844"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="850" mass="87414" checksum="E98C9584B98AEFBD" modified="2018-07-18" version="1">MVAAPETLVPAQQEAAAVPRVDQAAQVNGSVKDVAAAQNGPSVNEPVSPAAESTASPASPANLPPAEVARNIPCRFFPLGQCKYGEHCIFSHGIPGTAGSPGVPPSPSVAAQIVPGSGSNGQHGHGQQRQEHSFAQASSSSSYQQQRHGGVHAQQQPPHHFMPQMMPVSMEQAAAYGAMPMYYPDQAAGLEYGYPPQVAFGGPQPGYYYPPQFAGYPPAGAAGQFGGFVPQPYYNPVAAPPAPHQQQHQQQQQAIGSPVEHSIAAVSPPPAAVSPEAQLNAAAATASTSTSPAPAADNVESSPTVAEASAVEADSVVDATAVPPPPPVASLHTFFQTGPPVNGMPPAMLAPNGAGAPFNKGGPRANGPMGPRRSIGGPNAGPIPNGLHGKRASFGGARPPCSFFEANRCRHGDKCAFVHLLPDGSDARGLGRGLIGIDGRTEHPEATGGMPPAWLATQKALKAANQTARKQLEAGAILNGGYSYRERMSTQPQPTSQQAPTTAAPQEQQQQAKAPEASAASEQQSQPETSEAPATAPVQQLQQPQVPHAPVQHVQQQQQQRNGAPAPGSAAPQLVAAINGLTRRIPPAHLNKQHQHQHQHQGQHQGPAGPKQNQHQNGPKQQQQQQPPRAQRIPSGENDFPALSSAGPSSPIIEKEGFAAALAAPAPAPAPAPAAAMPTPAPVAEKQEAVLKPTSPSVDETEGFVMVSHSDAGVTAPEKQAASTEEAPAAPTPAPAAAAPRPKLIGGWASAAARGASVAVPEKPKQRAFSPVVVNRSADAKEAASKADKDDKAAAPATAASSNAAKKDSREKVDEDGFVRQQPKRKGGAHKAAKAAQQQQQQQQPVAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAL7</accession>
    <name>A0A2S5BAL7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_3363</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAL7"/>
    <dbReference type="STRING" id="741276.A0A2S5BAL7"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="315"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="381"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="509"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="739"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="650"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="758"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="799"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="823"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY73822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="858" mass="88808" checksum="4F9A7980B1285467" modified="2018-07-18" version="1">MSVAAPAAAVASRAVSASPSVASSSVTDPDGDSIILDAHPEGTADTSGTTRSMDAPAPANEQGVHPSGPVCSFGPRLAYTYFPTPGPTAELLNALTPGSPGRRTGTAARAGKGHGEGSAAATMASGSDDDSQGIYWFSIDDQLVYLSFFQDYGPLNVGCLYRFCLHLHSLLTSEEHAHQRIFLYSSDEPDKKVNAALLMALYAMVVMRWSVADCLHPLSALELQPYRDAGYSRADYHLHPQSILYGVHRALKHNLLDLSSFDLAAYEHAEKVETGDWNWITPGFVAFASPVEAGWSASLGSGGGGSVSGSPRRAGAGTSGPGGKISRAFKNVLEEFENKNVKVVVRLNKKLYDSGHFVTRGIDHVEMYFDDGTNPTLDMCRRFIDLSDRVISEGGAVAVHCKAGLGRTGTLIGAYLIYKHGFTADEAIGFMRLMRPGSCVGPQQHFLYENQLEWVRWAAQDELRRELASQNGLAGRALAAAGAAAATTTSLAASAPVTVVASGVAVGASAPMTPPIRAGEDGEEVPTGAQTPGRDGATVPPVTPRRPPPGQPRKTPGRSRHAVAEPETAPESAGKTAAEVEEERMEGVVMSSPRKARTSTGAGAAAAAANDVKGKQKMLNGDLEEAGDDEGDQDDDPALLASPKKLDLGAAASAAAVPASPVASTRPKTPSASTRPTRIARPARPLSALADNRIVDRIGTSTITRASTRAGAGNAMGMARSKAAKDLNVVLETHATGTITAPGAAGSAGAQGRYSLRNGRTTSAGNVTTSPPVSQAGQPPNSPTKLPQSQRVLGKRDSVVTPPVSTGSTSSNSGTPGPGFDPAVAAAAAGAAGGKIVNGRNVRRRRSSMGGHETVNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAP4</accession>
    <name>A0A2S5BAP4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAP4"/>
    <dbReference type="OrthoDB" id="2570975at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="265" mass="29051" checksum="2A2417E0F50EEF09" modified="2018-07-18" version="1">MFPPSPPDHTAQTSPGAPPFPPFLGPDGVTRIPRSLPRFPAHSTPLETHLPIDGELVPVAFVHDALRNRAYDLLQSVRTASLDGLLPGSPRRLRRALVDPALPRPTNVLEISFDDSDDIVEVVCHAVVLAASGSPILSRLVYDVDQQNLPTPCVSASPDSHPRQQITLPVIPLRLPRISSWQPLHDWLYERSSTKLRLDLVGTDTEVLAPVGAEKAVLAGRRTLIGRLDGIRQLWLNVVGLELKDPELERVMAEAWTSLHDALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAS5</accession>
    <name>A0A2S5BAS5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAS5"/>
    <dbReference type="OrthoDB" id="2524808at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="551" mass="60377" checksum="4674EFD7E7B43DC5" modified="2018-07-18" version="1">MQPVVPYDPPYPSRAADPAHAYPPTGRRDSVFHRAEHRLDEVAHAADDAEHLFQEVGKAARVGRHLVEEVDEAYGDVSRPPLNERASSTSLPAYGASGILERRRSTASIASRKTDDNWQKLLVDLEDAQNAIGELHGDVEGIADQRTRLTGVSYDHSAPKPRVAAPSAARNGSAPRQLQQQAAHVARAIDDFLEQYKAVVAFPDRLAKLAKQDPHGTDVNRAHKLLARINSDFAELLDFVETRADQEKREIADGWSDSRLQALIVEDHPTWYQNKILKELREARADAKWQTFAKVDPGSYTFRWMLEHPFMQIDRAAVSTIDLAEHRIKNRKDEKTGSWALGGLLSKVVSAASGKRTGTEYHEIGKGGRRSVRNAYSEGKGTLPGGESASDSDDDLEKQKKKLLKGSAWAVDVSKLPERVPTDDTSGYQETKAELLEDAIDESKTQHILTPLVALFWVGIFVLYGYYLIARLIGHKDPLGRIDLGGTFGNDRWNDTRDSDPASGLGVTTTDAAAAAKASAASVYSMASVLHSAVTELGARSLAPTATSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAT8</accession>
    <name>A0A2S5BAT8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BAT8"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="865"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="1276"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="1310"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1534"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1825"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="631"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1736"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2070"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1745"/>
            <end position="1755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2089" mass="222745" checksum="9044C630E9ACF210" modified="2018-07-18" version="1">MQATSHTRPPDDAGTRTATAEPGSSSDMTTDQAASRVGPNASKDAPQGGVPLEMPLPEFPVLPPPSTPAPDQTFQTPSQVSAILSLPPPLLMQLARTDSPAEQLHIAEKRGVKGYLSAMAIPPPSPTSLVESIARENAADVAASTAAAQLAPTTTTTTNNGSSRVPTLSVPTSAAMARPTLNIPPSIPLSLPDFSAGAAGTSTFASASPSSMNGSVANATSNGSSRAQIALPLLLGQVFAPPPLTPGVLAPIPGLGSVSSLFTSTGPGVRSTLRPDAGSNPTSPTTPRVSFAPSIDDWSFRTASLRAAATTDPLAASRGQDSASTPTTWTSSGAGGSPLLDVGDLARQIKDWALETQERQVEVQVVEAKATAVVLAAQAQAQANLGNGDAVASTSAAAAAANGATPTLIGTGVGSGVGAGLGHDGLQAYAEAYKKQLDALASGYFAQLHRDALKRIEDETRSRSSQGEAGSTGSSRRPSESGGVASTGAGAAAAAAASEAWVLPQSTSSALSTAYGSASVYSGATDALAPTPLSSSQAPTLQSLTTLTSSRSQAEAMHVRASAAAAVAAQVMAAQDLARSAGEKLVEFGVDPRRVVEHVGGLVDRRGSGGSLEASAELEEIIGKAVAVASSRRGSRDERAGAMTSEMSRSLSSGATSDAMSIEDVGQPAVPSSAAALPATGPVPSNGVPLGSGAAPVTNEGQASIAELASLPHANRPQSTAQIPASAVAQAGAQQLGSGSAGFMPGSSVAAAAVAGQVLPAADTAAQGLIDRPTYGMPGQSTTAAEYAALATPEKRDYLLSYAHQLYSTDPRHAQLLPLLHTIEALHPDHLPTLLLISCVYYSRGELESSLYYNKRLLHIDPSYVEAMSNIGTTLRAMGKWSEAEKWWWKAIKLRPTYWDATENLLGVLCNPAATIPPGAANPATPEPALPDHRYKEAIALCDYVEAQIFAPTVVAAGLIAPTQEAFLNPLGAVPRPRVLPATVPHNHVHRLQNLFYAKGNLRLALGKPAHAQEEYEKAIEVGLSLPEWARRVQGLHWPLEGCSTRDLVVAATVIAKLLAVHAESKARQAGTQNVNELAQQLGITREDGTIAFERVFRTVRDGGDAYCQQLLAMGGGVLPTILLEPKALASMPNMLFPESKGVIPSMFDPALLAGGPAAADPARQSVLTSTNQTTSTMLLTLAKVIQDSLGPTSTRRLTIGGIPASQSLLLPLYYVALALYPSPSTCNNLGILLSTLTATTIVGTEDPSHPPVILSGQTLALRYYETGLKLDPKHPHLYTNLGSLLKDMGKLPEAVAMYKQAVTFNPGFDVALANLANAVKDMGQIQESIPYYRRAVQLNPNFPEAICGLVNALGGVCDWHGRGGVGEVWIVNNENGLEYVQPGADGQLVRRGYMEQISKLVQKQLKEGYAYGAGALSSYGSVEDWLELVSGALYGTTASQMPASAVNLWSARLTAVLTVQDRHKAFFNEGGYLIRLIERLMRRTQRRWFLTAYGQSLGYEPGQAVPNRIRPSRADVNLYRRITLPPSLPPIPVPTVLPFHCFTLPVTPRETRLISHRTGLRISHSTLNQPWMPPIVYPPPRPPIDGKINLGYVSSDLGNHPLSHLMQSVFGMHDRSRFNIFVYATSPSDQSPYRLKIEAESQHFVNVSALSTQEIVQRIVQDEIHVLVNLSGYTKGARNEVFAARPSPVQMSYMGFASTLSAGWCDYFIVDPIVCPPSLVSGNYWRRISEVAHPGRSQRKPDMTEFEGDPDPEGPSEDYVYTEKLLYLPHSYFVTDHKQAWREDDNVSVVPGEAAITSSLPTSGETAWAIEEHKRWQMRKQMFPQLRDDTVIFANWNQLYKIDPFIFRLWLSILQQHPNSILWLLRFPAPGEAHLKETAALWAGQDVADRVVFTDVANKNEHIQRGRIADLFLDTTECNAHTTAADILWSGTPILTFPRHLHKMCSRVGASVAAATGLGPSMIVSSDVDYEHRALDLAGGLTYEYIAPDPTKPRTSLEGIVQRRARGELANLRKQLFLSREYSPLFDTQRWVRNLEKGLIEAWRRYVSGAEFEDSPEWGRGDERKAASIWITDDNDGANWPAREPYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB13</accession>
    <name>A0A2S5BB13_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2783</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY73972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB13"/>
    <dbReference type="STRING" id="741276.A0A2S5BB13"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000076">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="380" mass="41840" checksum="F7BC5DFC8BD78AF2" modified="2018-07-18" version="1">MSANFYLSSHANNHLHPHAALLMARVDDLKHATELELAWIEIWSASTMQKICKRLGLRQQVLATAIVFFRRFYLRNSYCDTDPTLVAATCCYLAAKAEETPVHVKTAANEAKAVFHDMGLTSYSSDNHRLAEMEFYLLEELDFHLIIFHPYRALVQLCGREGGEQNPEQKAMMLEMDDTALQMAWCGRQLQLTEEFIVNDTFRCSLCLIHPPHLIALAAIYLAFALHPPAANATQILGAEAPSTNVSSRTRRRSTDPNNSNATPTDDSKPANDPVSFLASLQVDQSLVLEIIQEIISLYDLWAQLEAPAVVSSPAAQQLGVGASARLSAAANGTVGAGVNVGGKGTPDDKVIAIIRRMQEGRMRELRDERSKLAAARKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB20</accession>
    <name>A0A2S5BB20_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000031">
        <property type="protein sequence ID" value="POY73957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB20"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="262"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="264"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="696" mass="74791" checksum="1DAEB3EFB10AD143" modified="2018-07-18" version="1">MYSAYRHPQQAVGSSRSDAMDGEAQGYPPSPSRRAPSQSEEYAYRGDDGYRSYGAALGTMPDRQVASSVRPRTAPFLDRSPRGYDGRNHDSAYDRTLSYGGSANVKSPTRNQGATALLQQHAANQWAFRANQTNLPPAPTASVLQPAQHVTYSPTRVSLPRSGDAEPSAPHDYPSRAPRTITYTPYAYGSVTNGASRPPLSHREQSSSGSSTSASTPGTSQAFLPGRGPGNGLVDGHSNHTRSSSSGQPVSNADFSRMFFDPLRIKQRRRTSPAQLRVLEHHFEQSPKPDLALRKRLANELEMTPREVQVWFQNRRAKVKKLAERAERANGGQSTTARATTADNDSDDQVGGGDDVHDGDETAHTRLRTASAPSSSRRPRPSPRYSSSDPSVQYDSESAELPDPTEYVGAPRAHIYGEPPQQQESATNDELRLPLPPNPNDHFAYQGNPSASGRRYSLPAFASSVIPPSPHDQNGHVAPSHPSSLADAYPASLYVPSSASGAGGNRQHPSVHSVGSISRQHPSMHSLGSASSHADEHSPAQSVSSRASETIPDAIPEYAEVSHWNSAPGSAPEHPPTGYLAARRSSVPSRAIPMYDGDNRSTRLSMPVPEEAPTQMGANGDEPGLAYNPAVYPPPVSMIDPVASVAFLHGNERVTPVSYPYPYVHPSATMQDVSDGMVEEAPLYVTAEEIGGRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB30</accession>
    <name>A0A2S5BB30_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="5">Glu-AdT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000030">
        <property type="protein sequence ID" value="POY73967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB30"/>
    <dbReference type="STRING" id="741276.A0A2S5BB30"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="555" mass="57821" checksum="C6C2B621A9DB7460" modified="2018-07-18" version="1">MRATPVRSVPARIARQLERAHELNPRLNAFTHLYSPQGSSRDGTADGCGQAGSLQGTSVAVKDIFATADDAPTTCASKTLRQYRSLVEATVVKRLRRAGATLTGKTNMDEFGMGSANVHTDFGPVVNPAGPGGVEASLALPVDEQRAAGGSSGGSAAAVASGLCDVALASDTGGSTRLPAAYCGIYGFKPSYGLLSRYGMVAYASSLDTVGLMSRDASKLAQTFDALEAFEPLDPTSVPTAARERASAVHASLVETLTTAKTDRPLEGVRIGVPADLIPQPLLDSKTLLDPFRTFLASLRTLGASVTSVRFPAAPLGLSAYYVLASAEASSNLARYDGVQYGYRAAESDGTAEGDGHGEKGLLYAKTRSAGFGKEVKKRILLGTFALSADAFDNYYLQAQRVRRMIQLELDGLLRAPNVLQSPALASTAAAADMNSGVDFLVGPSALSTAPTVSSATSAQTTSSTASSGTNSSTRPDGDSSAPLQNSYLQDLLTVPASLAGLPALSLPAGRDASDGWPVGVTLMGQWGSDRAVLEVAQRWEELRKSRGEWEEGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB62</accession>
    <name>A0A2S5BB62_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB62"/>
    <dbReference type="STRING" id="741276.A0A2S5BB62"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="10">
        <location>
            <begin position="59"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="478" mass="51332" checksum="7DE0F0C70ACDCB09" modified="2018-07-18" version="1">MLRRASALVRVQAWRTVPTSCPRCARPVATSAPRATAASLAAVNHDLITRYAQTPTSTVTFSDLLMYGTPPLDEPTLLKSAERTRSELMAGLARRVSQHLSLPFLPATNPSLAKVHSLYSSAFSDLSQIPEISTLADNDRLCEIVAKMVEEHRDNIPLLAKDRVALIICALLGFKECRKYLPDATITDFLDRAIRNRISLRLMAEQHLSLSSASIPHLRPSSHSNSPEPNATPAPKDLRVEPSARPPSSSLSASRVGILDLALSPHELISTCAEYVTLLCESTYGVAPPYRIEGADSATTVGSVGSHLEYIMTELLKNAFRATVEHNVPKQDQDDDDPDVFRFEDLPHAHMMKSDFPEVVITIGVVPGAMTIRIRDRGGGVPPENLNNVFSYAFTSVPLLPDPDSDPDSPSTAVYGGTSNAGYLGGVGGGPQGGESALQTNVGTLAGLGFGLPLARIYAGYFGGSLDLVSMYGWGTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBD3</accession>
    <name>A0A2S5BBD3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">BMF94_2901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBD3"/>
    <dbReference type="STRING" id="741276.A0A2S5BBD3"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="216" mass="22877" checksum="AA9A6535D4451A06" modified="2018-07-18" version="1">MTGPAPAAPAGPMPSNEAVAPRQQVEQTLELLLQTLLEMGICASDVQESALEGAEGGVAYGQPAGLLGRKALSREHSRTSNTRVLTAASSPCSFCSPSISQQTVDQLARLYAQKDSVNEINIPIEVINLVDQGKNPHLHTKNFVERLAGENMYTNGILSGISDYRDLLRAQLGDAFPELAEDVKLMSPAQAGDPPASTTAAEPSMPNGQAKMEVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBG0</accession>
    <name>A0A2S5BBG0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_2912</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BBG0"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000819">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056890">
        <property type="entry name" value="UBA_DHX29-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24899">
        <property type="entry name" value="UBA_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="748"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="995"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="227"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="319"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="438"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="667"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1518"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1534"/>
            <end position="1547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY74100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1547" mass="171232" checksum="6A255D8C46CB2F87" modified="2018-07-18" version="1">MPPKKSSAAKKKKNLGSARGFATVSVPKRVDPTAEEAAETTDDAGAAVAENGGAAAVDGEKGVGSGTPAPGTSNGSRPGATSDANGVDAKKDTWEDTPEALELKELQELAERIKPGCDKEISRIVKVFEYERRMSKTLPNYAWQEPDLQRRVLDLALSETIEEEPQPVFEPRDRVVAKVATLYGILEQLGFRSERIEECLNKVKTLDIDDCLDWLYLRADSDELRRQRPMPEAVVDTAPPTPRSSRSADGKGSNGPSPNGKGSNAPSPAANKGNSVPSKLSRTPSSAASPTVNSTSAEQEAALRARVLAYGEELDKALAASGRNSSDSGSESGGEGDESAMPDANVKYATLKVQLSEVQRAQAAQKRATKGRGDRKGTEPVSVEQEKWMEAQVEVLQERIKAVESDYTFRKVDAEKVYRAERTKLDASQLAARLNGTSLASVPSAPSDATSDATGSLAPAAPISEGTTPASTANGKAGFSSPPSPSASANGVSDNKGDDEGFFGTMLDEMPTEEQNDQGTTIPVRNMALPKHFSGRTPRVCLEDTVRKLDRGARVKFAVVSRSRAVRASVTIYWTPDDSATPRRRVQYFDMQDIACWDQKQAYDYIATVALFAIAMSPQGNGMAINKALPTIFRDLWDDFLAERTAQEEERYREKLKLYKAIAEPRCQDSPNRDTRSARTEKPAAEPSIIAPRKETSPETAERIQNDIFNRQTWPAYQEMLQQRANLPIAAYRSSIMETIESSQCVVLGKSTQVPSFILEHEMRLGRDVKVYCTEPRRISAISLAQRVSQELGEAPNACGTRNSYVGYSIRLDSAVSASTRIVYATTGIVLRMLEGRESLADITHIIIDEVHERSIDSDFLLIVLREILETRRDLKVILMSATVDAEKIAAYMDGCPVIRVPGRTFPVTPFFLEDVVELTHYRLDAHSDSPYVARNKRAYGGKRRMVDDIPLDDDDEDDLPAKSADVTQLPISKQSRTTLDCMDHHAINYELIVSLLEHLCFLKPDLIQFSSAVLIFMPSLESIRRLTDMLEAHHTFGSNQFVVLPLHSTISNENQGLVFNVPRPGIRKIVISTNIAETGVTIPDITAVIDTGKHREMRFDEKRQISRLVETFVAQSNAAQRRGRAGRVREGVAFHLFTRHRHDNYMQEHPQPEMTRLSLQDLALRIKIMKIGSTGIEETLLKALDPPLVANITRAVSALVEVKALTTTEEITPLGRHLAKLPMDVHVGLFLILSCIFGCLDAGLTIAAGLNSKSPWLTPFGREAEADAVKRTFKVENSDFLTLYNAYCTWRDACSNNYEREFCRNLQQIEELRQQFFSFLVDAGFVNITNAERRELVSTRYGKSRTKFVRVPADLDKASRDPRTVMACLAASMYPKLLVIDPQNGSLRTLANSAPAAIHPSSVNFAPGRRVDFGNGTRFAAFFQAMHTKKLYIWDSGSVDEIAVHLLCGNADFQLPAQSISIDRKIRTRLEDPKTAVAIRCLREKWREIFNRKMRDPAAPIDARLEPWLALVTEAVKSPHREDDEEKKRKKQAERAAVKLSLTRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBS1</accession>
    <name>A0A2S5BBS1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBS1"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="307" mass="34612" checksum="00F50B592E727B26" modified="2018-07-18" version="1">MDALLLHLIPARRAITDRSGRITCSVCGADAPFRCGACPAEIGAFCSKVHQRLVWPEHKAVCGEGKAKPFLLPDLTDHDLGLFARYWDQPAFYERRHEHLGHLMESLFKLPAESVGATASSLNERIKSCGTIDGFAAPVVAAQILYGSLFEKHPCISQLEKTEFPAACELDLSATCFISIVLFHLKGFQITLPPNAHDRFMHRLVIWWALLRAMYRQQQTKRFTPVEVTVEHLDNAMQLLSLEVLPFMPESLLWSSFFHFITDPMWLIPKMRAYKSGPAPYGTGRSKIWRILPLKEAPEGENSARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBX8</accession>
    <name>A0A2S5BBX8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBX8"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="248" mass="27855" checksum="75F8A8F126F582B8" modified="2018-07-18" version="1">MARPRTATKPHVCIVCGKQAKERCPPCWDAGVVTGFCSRDHQKLVWFGHRDVCGANANPCMPPPLHAQEIKWAEVSTPSPKQLKWSLDMLARPDFRKHSPDAARDCLFRVRAVVDETLISPEQVSVSHPSCILARWNAIFSQLGEDGDIQEDDLPHELYHHLQVLATLVYLGRKPVSHRPKAFKTEFVVDVVKRTLELLAPIHTPGESTKLFKALRTMVKSVVNLQGEIGRREDGMTGRVEVYQIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCL4</accession>
    <name>A0A2S5BCL4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCL4"/>
    <dbReference type="OrthoDB" id="2533458at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="142" mass="15152" checksum="0BA1208BC8831B15" modified="2018-07-18" version="1">MGITDTLKSVVDSVGYPNGREESAQNSKVAHEHVAMGGAGMQDHEQPTSLYDALHGDAGLRNMKAHGNIASGHDAGLGAKATAHQEEMAERSRLRNEGMFVPHTTHEGLMNQSDEHREVAMGSKLADHTGVGASEVDEERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCR4</accession>
    <name>A0A2S5BCR4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCR4"/>
    <dbReference type="STRING" id="741276.A0A2S5BCR4"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="93" mass="9974" checksum="F4B7C58CEF452D67" modified="2018-07-18" version="1">MTNSQALDHVKSTTACIAGALAGLLGLTSLNGFLLYLAVSLGVGALYSAVNCKGEPARYFLKPSEPVLNGTVGNCFPFILFWTLFYSLVYIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD09</accession>
    <name>A0A2S5BD09_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BD09"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="620"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1479"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1953"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2209"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1953"/>
            <end position="1971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2228" mass="243165" checksum="F2D136A3C110EA36" modified="2018-07-18" version="1">MSDSEGPPRVETAAPRPKDELDQLVNADNAAPDHHHLSPTDTDAVVHRVHRDSAASVERVESSQRDDASDAVESVEQQSAQSDQNDPSRNDDDDAAVEPAEPLPSTDAVTPDATATETWSETSASGHPEGAPAAATPEHDDDDNKAEPSSSAPDEPPTHDSPNSTLETIAETRDVDLPSDASPPAPAGGGNVAGVADHDRERDDAPAPIRPELAELRAATEREQEDLVADTPVVPSLEPGGPELPLTEPEELEETTELEGLPRAVESVEEPSMPTSVQEPMSLEKVQEVAGLAGTEEPVVVGPEPSAAPSLSRTESNAPSVAASTTAPATAASTAPTSQHEAANGDASKTRRESMASVTTVSAPGSSHLVSGILIVSSLESIAATKEAKKSKPLKDALDAALDSLKSPVNAAGTATATSAMVDPHVVFLPLRLACETKSLPLMITALDCLSKLVSYDFFVDQHDPAAPQVQLARDDDNESLVGGAGQQQNNESLPLADQITSTVCDCFSPSPVSSSGSSSSSSAANAATTQHDTLLLRLLSCLLGLILSSSLPVHQSALLKAVRTVYNVFLLGRPGTVQTVAQATLGQIVGGVFGRVSFGETLTVPSSVGGGVNLAAAAAATDDGRPKSMPTPSRSQSRTDLASVAEEREGDSAEELDEGEAKVNSVRDGRVEVDADADADQTPRVSVTEDPSAMAVTAADQPEINGSGERVTSENLARLNGTPIPTSDQVSENDLFIKDAFLVFRALCKLSMKPLGADRRTPAATGRLQELTQLRPYSERDLKSPAMRSKLLSLHLVLTILHNHIRLFVDPTVSIVSSTSRERTPFLTAVKQYLCLALSRNAVSPVIQVFELSCEIFSRMLSVMRQRLKKEIEVLLNEIFFPILEMRTSTVRQKSLLLAAFARLAQDPQALVDIYINYDCDRSSLDNIYERLLNIVSKLGTTHFPPSAPEGKAGQPIPSALSAAFAPVPLSSTSLSDESRFSDARFVGQPVEAHIKRQSLECLVSVLRSLVSWAGRNATSAAPQPVASGSTTSLNGSGTPHRRSDDGQRDGTLSPGLDDRRPSFTGPGSDRNASGGVNTPDVPAGDDPSRFENAKLRKTTLLEGIKKFNFKPKRGIAFLIENGFIRSSEPKDIARFLLHADGLDKAQIGEYLGEGEPANIAAMHAFVDFMDFTNTRFVDALRMFLQSFRLPGEAQKIDRYMLKFAERYTAGNPETFANADTAYVLAFSVILLNTDAHNPQVKKPMSKVEFVKNNRGIDDGKDLDEQFLSEIYDEINANEIRMKDEVEAAGPQAPAPGLAGAIATVGRDLQREAYLWQSESMVSKTEALFRTLVRGQRRGGRATDEYYSASHAEHVRPMFEVAWMPILAGISGPLQDSEDLDLIKLSLDGFKHAVKIVCLFDLELERNAFVTTLAKFTFLNNFGEMRAKNVEAIKTLLDIAMVDGNYLKGSWREVLTCVSQLERFQLIAQGVDSQTVPELGRQPSLGRRRSTVTGKKTNRPTEEVALETRSQHITITADMIFSSTPQLSGAAIVDFTRALSEVSWEEIQASGLAEQPRVFCLQKLVEICYYNMNRIRLEWSAMWLILGEHFNQVTCHTNAKVSFLALDSLRQLAMRFLEKEELANFKFQKDFLKPFEYAMIHNTNPDARDMVLQCLHQMVQARAQNMRSGWRTMFGVFAAAAKVSTERIAAQAFDIVQRINREHFSQIVEFGSFADLTVCVTDFCKISKFQRVSLQAIELLRALIPMMLSCPECPLSGANGAVPVEATATDDPMLRFWFPLLFGFYDVIMNGEDLEVRKRALDYLFETLKKHGQSFPPEFWDTICKEVLFPIFAVLRSRSDVSRFSTHEDMSVWLSTTMIQALRNLVDLFTFYFDVLARMLDRLLDLLSECICQENDTLARIGTACLQQLVEDNVDKLSADRWERIISTFVHLFKTTTAYQLFDPTLLSPQADAGPSSKSKAPSPASDYAPLAPAPSTPVAAADGSPVPPPKPAQPVDRRRVFRQIIVKCVLQLLLIETTHELLQHERVYKTIPPGELLRLMAALDESYRFARKFNADKDLRMALWKVGFMRDLPNLLRQESTSAATLVNVLLRMHNDVQPEAVEKRAEVIDVFVPLALDVLANYVSLNPETQARNITAWTPVCTEILQGFCSFEDEPFKAQLDQLYPLVTNTLVRELDPALRECVRQVFVKVGKVALAIHDEAPHVDTGAANEKAAAAPPTPPTKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD62</accession>
    <name>A0A2S5BD62_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD62"/>
    <dbReference type="STRING" id="741276.A0A2S5BD62"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="49563" checksum="2AFD421A96707931" modified="2018-07-18" version="1">MPVAYAFDVLGSDSGWWTVTKGLAALSLAWGVRTWSKGYVCREHRELAGKTYILSGGFSGVGLSVLQPLAAAGAQVIVLTPEPLTPSVVQLLLLLRSATENERLYAEQCDLADVASIRTFVAGWQKEARSGMVQDLEARIDGLVFCDEDDVTELPGIGCRPAATSADVAGAGVSKYGMTRLTGRHALVQLLLPVLLRSAATLTSPLRIINTVSPFYATVTPATFRPKDLEYSADLKGVDAAPYPATQPWIAQGQIALASVLLWQEFHKRAKSTTTTTPAAAAAATAKAGEGASPLADVAAAAAAESTPVLALSACPGLLRSTIRSLLCASPSSPSFSVFGCAVYLFLFPLIWLFAKSADEGAQCVLAVLMADVYREGETLDQRKRRRDKAARGPDGKVDAAAAAAAKDDDRPPLLVRPGALYREGLEVRLPILGALAPDVSAQVWDAQSKTVETTLARIVKEEKDAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD68</accession>
    <name>A0A2S5BD68_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD68"/>
    <dbReference type="STRING" id="741276.A0A2S5BD68"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="452" mass="49437" checksum="834BC9328AF6DE6E" modified="2018-07-18" version="1">MSLTASMSALRLISPSSPRVSVEPFQRCLCTPTGSRAALDRRGYPPRKRIRPLVRHYAAAPAEPASFHEHLVSTAEIVLAHAGMQSEEGYNAAAQEGVDSVQAAKRESEMEKVRQALRELEDGQELVLSLRDLAESEPDEDMRKLAQSDLPVAEDALRSLRTTLLEALAPAPPVSSLSALVELKSGVGGNEASLFAAELVRMYQRVAQRKGWKASVVEAVTVEGVGAGSSTGGVAGAYKEALLEVTGDGAFGYLRREAGVHRVQRVPATESQGRVHTSTVGIIVLPSESATGGGQIDDSDLFEAKDVKIETMRSRGAGGQHVNRTESAIRLTHLPTGISVSMQDSRSQHENRTKAYRVLRARLLDRKLQAEQDERRSVRLNQVKGTDRSEKIRTYNFPQGRLTDHRIPLTLSALEEAIEGGEVLDIINRELEEREDRERLDDVVEALMAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDA8</accession>
    <name>A0A2S5BDA8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDA8"/>
    <dbReference type="STRING" id="741276.A0A2S5BDA8"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="186"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="403" mass="44785" checksum="4BD00E80929C243F" modified="2018-07-18" version="1">MLVDGDLLPTVSFGEDPLSLNAAHLSLEDRTELELYLDTYSGPRLVQLRQEPTPRWITEGEKALLVWNHVRFVDVTDDDQTHGSQLQAPTSVTYPAKLSHDEKHLRGLFKRIDLGAMKQFLRQFTNFHTRHYRSHYGLHAKYNPHANITFTEFKHSSWDQKSIIAHWAPRSRHAGSDNTTADAATAPVIILSAHQDSTGPLPFMRAPGADDDASGTVALVETVSVLLQSGWEPVDRPVEWMFLSAEECGLCGSEEVVRSYREQKREIKAMYHMDVTAYLKPGTEPVIGLITDGVSSALTDYIELLIDEYATLPVARTQCGYACSDHGSFDKAGYPAACLSEGKFADSNPHMHTADDTMDRPEYSIEHISEFVRIGLGYVVELAGGLKEGGGKKGAARRLDRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDE8</accession>
    <name>A0A2S5BDE8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribophorin II C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2079</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDE8"/>
    <dbReference type="STRING" id="741276.A0A2S5BDE8"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044277940" description="Ribophorin II C-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="10">
        <location>
            <begin position="188"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="300" mass="31630" checksum="73D5F8FD15D01753" modified="2018-07-18" version="1">MLRPLLAGTLALLASTATATLAVRDGKLSVVDSVSASLVGSTALTEDYRYQLTDTDSLKLQFTVTRDGNPFQPQQAAILVSPSSSSSSTTTSSPRARAVQVPVKVRANSGKAKIDLDADTLAQGGARGAVDLTLLVGHPNQSPLAIPLGTISLPESVAAASGRADLERLPKHWEAEKYAPQPEIRWTFRGGENQINPVVALVGLAVVLAPWTILLATIPRLLPQGRLPSPSLSQALFLLSLVALEGLSVISWVYFLPILTTLPYFGAIGLVAVATGRQALGEMARRRKIDAVGGAEKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDG9</accession>
    <name>A0A2S5BDG9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDG9"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="265"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="471" mass="50251" checksum="597FA7FD7B663A25" modified="2018-07-18" version="1">MRRFPAPPTAAGPSTPGQARSAEAPMQYEWEKPRQFPASPFAAVASGSGSTPDMEPPKKRTHYEAMDLDTPPPRPTASFPPAATATPGPFRFSASSNIPVQSGDLYPPAFNAGDFHPKEAFGLADEPAIQEISMTTDDPGELLGPTQDDKENLALTLREDEGAPTQRGAAGGEARKRTSRRRTATTDEEETDASDADEAAKSTGFLDVLKGKTGRRSGDSQFSFQVHHHHAPGGGLQLSGPGSVASGQPQEPPEKWLRGSTPYVLLGYVQFGSLALLSLLVISLLILFLSTLYYDIQARLAEMTVEMRGEMIQCAKAYVENFCQDRRIPALERQCNEWEECMNREVVVVGKTRVVAETLADVVNGFVDVISFKTMLFVVLTLGLTIYGSSVALANLPARTPAAATPPASPVGGPPPHFAHLSPYGAPMYPYGLPYNAGATPWVVENGNAGDAGSKSGRAREDAVGPARIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEE9</accession>
    <name>A0A2S5BEE9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEE9"/>
    <dbReference type="STRING" id="741276.A0A2S5BEE9"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="4" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="297"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="435"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="607" mass="63549" checksum="8D47815B7D838F5D" modified="2018-07-18" version="1">MSALPASYSALLSDLNRDVMRAQPADPLQFCANWFATRLEEERTVARSVTGPSSAHGSTFSPSHRFRPSADDASMRNATPPASSRSGSGDASASHRGSTASFGGKQMPPPALAFNQDYAFGGHSAGTDSNRPSPSTAEFPAAAASGSSPRGSHANKPSIASSLGPGPDTTPTARSPGGAASRSTSGTGPVNRHSTAGTDSDEEVEDPRDDPNFHPGKPGAGGPFANFGSQTSQHGGALPGAPASLAIPVSYNLGRRTSVSAESLDPSAATQALPKTVIPKTASQRARIEKAIANNLLFRNLDQEQHDDVLNAMKEVTVQPGTEVIVQGAVGDFFYVVEEGTFEVWVRAAPTHTYAGPGQSLVTQPGEEKKVATYGPGGSFGELALMYNAPRAATVVATSRATMWALDRVTFRSILVEHTSRKRKMYETFLGEVSILQELNAKERAKIADALEEKVYEESEAVVVEGEVGKNFYIIESGEAEVTKRKRSAQGSVEDELLGTLRKGDYFGELALINSAPRAATVRAKPGSGRLRVATLGEKAFTRLLGPIIDILARKAERSYGPAAAVSSAASPQASGSAAPVDRRESTFPTSPAAEIRRGITVGGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BER0</accession>
    <name>A0A2S5BER0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BER0"/>
    <dbReference type="STRING" id="741276.A0A2S5BER0"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="359" mass="38733" checksum="63C48B626A16CAC3" modified="2018-07-18" version="1">MPQTEPTYDYKYLKKPLTAGVIGCPFSCRRKSLKAEGTGREAATHALNAEQTGPLELIEAGLLGDIEALGWKVDFAGADNLSKSITAEHANGSDPDIGKLKQPRLVSQVNKEVAERVYAHSSKGELTVTLGGDHSLAMATVSGTFKAHPDAALIWVDAHACLTTTLPEQDINTPLTTPSGNLHGCPVSFLMGLPGTSKEEIPEFGWIEPVLKAERLVYIGLRDIDEGERKILKDNKIKCFTMHHVDKYGIGKVVEMALEHVGQDRPIHLSFDVDALDPTVAPSTGTAVRGGLSFREGHYICEGTIRRFEGQVAVAETGRLVSLDIMEINPSIAAMEGDVQQTVDVGRSLVRCALGETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BES3</accession>
    <name>A0A2S5BES3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BES3"/>
    <dbReference type="STRING" id="741276.A0A2S5BES3"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="30"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="392" mass="41890" checksum="38E089CECBD70D25" modified="2018-07-18" version="1">MSTTASSFKQAEHKLLSVPGPVEVTDEVLFANAHPSMSHVSPAFAPVFGDCLRYLRKVLYTEKGQPFIIAGSGTLGWDLVAANLLEAGQKALVLNTGYFGDAFADCLETYGAKVDQLGAPVGGRPSLEEVEAALKKDKYAVLTFTHVDTSTGVLSDAKGIAETVRRVSPDTLIVLDGVCAVASEEIRMDDWEIDVVVSASQKGISVPPGVSITALSQKALKVLDSRKTPIPAYFANYKRWLPIMESYEKGTPAYFATPSVNLIYALEASLKSIVDGPVSLEDRFKMHKEAAKKFREEFMRQAGKLGFKTVATSPEGAANGMTAVYVPEGVAPPALVGALAERGIVIAGGLHKDIKTKYIRFGHMGVSVVERPSDADKILAALKDALQAVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFF5</accession>
    <name>A0A2S5BFF5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFF5"/>
    <dbReference type="STRING" id="741276.A0A2S5BFF5"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="313" mass="31918" checksum="07C7D2CCB8D0A8BB" modified="2018-07-18" version="1">MQPEADAPSAAVAAPWRANLLSLDNPHPSPLSGTRDLISQFHLEPLYDTFLRPYLPSSLSSTAHLGGGGPHTDADQYSVGGASGPGGGGGGPAMTIGGQQSNSTHATTMTTLPPVPGQVVLQPAGGGRSHAQRGGAHVKATPASPTGTSTTAGGGGGLKITLGGIKLAGLNAPALAATGGGSGLAPGDSGTPQKKPRKPKMDKSYEYMVGDVLGRISQPRANTAASALSSSSLLHLVSNPDPAPCPPLHPFDAQQLREAFTLKPGTLAGFDMSIWEARDPNGGVGGPGDERRRKKKKRKHDDPNATDPKKQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFG1</accession>
    <name>A0A2S5BFG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFG1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFG1"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="773" mass="83684" checksum="75E1BAF84335327C" modified="2018-07-18" version="1">MKGLLPLYVTVDTARALLTYALLHSGVKLSPTAISLGSEALKLAVASIAIGWAGGRGAGAKQSGFLSRIALTAEGGSSRGGVAAYLKYAVPAALFLANNVMYLGALSYVTPALLQTCVLSKLPLTALLHHIAVMPRRGKEMWLSLACLSLGLILAGSPDALWDSQQRSKITFRDLITGPVIGLTIGVVSACSSIWTELVFREQVEFWTAQFWLYLWGTVLAGLAHLASHAIALAPPSSGKVQQQVAKSSAWPFIAVVLITACSGLSVAAILKQRDNLVKLVGSSLCITTLYVLQHVCFPLAEEVESRAVIGIGILTVSTWAYNYYKDQPNQDGGQTAEPALYTALQLDSGKPEDGSNLDGRPVARGEYANATEPSAIPRPTLFRLLLCGVIISLLAAVPPFLPRPARSIERDFTSFFSPRHIYPADWSKVSVRESQRCVMDAFQDGLEPDRHPSLLADWEERIVHSACPVYPVPDSGLTFHARWRDGTEEAHDFATDTFLASQRLRAGHRLIWWYEANGSSPASGPDEAFRARYLASESPFTPFVEARPLKLDDLARGTCAEESLKQPTSHELLRDLGRNLVLARYGGIWVGDETILLRDLTPLIRTGPLVPGLSDGTSPVDDLLLYGPAWSGLGERILALACKSFLSSDPARNLRGVHETCLRDPRCGVKPFPMQWATGSLVSEDCEPVEEAIFPSDEAETRPAPAHLHGIFAWRARVQSRSGEDPCWKAGSGSALAAIRARTAEILETMPLGLGVDLFPGPGFIDTRHELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG27</accession>
    <name>A0A2S5BG27_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase III subunit RPC6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG27"/>
    <dbReference type="STRING" id="741276.A0A2S5BG27"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="59903" checksum="3541A603F1EC8EEF" modified="2018-07-18" version="1">MPPRASTSGGGAAAASAKKLSPVELKLLNAGLAAKGGEMLQNDLFAACGLGVTATTMDAVNGLLRKGLAQMLRTPSGQTMFRFLGKEEAKAMSSMDSEEKLVLNHIRDAGNMGIWSRTLTTKTGLPRATIAKALKVLEGKKTIKTVKSVKTPTRKIYMLTGIAPSVELTGGPWFTDNELDVELVETLKKVVRKFLHQKSQPPSVTFTDPSTSEPVKIKPIYPVSATPFLPTSIQVLEFISKSGAAIVDLTKEHVEDLLDLMVFDGDVEKVLVNRLGADGLPVENPKRNKGKGTASSKRKKGNASSSEEEADSSDEGGASGRKSKSKSKKTSKRAANGKPKKKRAKRGSSDEEEDEESSDFDSDAEADTSSKRKRAADSGADDDDDGNGSASDGGGKKKSSKRRKKRVKSRVKREDGNDSDSSASEDDGRRKAANGDDEAAAGGAADGGSENTQYVYRMIRQYRPTVGWTDMPCGRCPVEEFCSEPPRRRAEVFRRPAQFGVKGGPSTHIEFEGGIKGIGMLGGAGAAIGVSDAKWGELKGGIGNGVAPVNPIDCPAYKAWLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG69</accession>
    <name>A0A2S5BG69_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG69"/>
    <dbReference type="STRING" id="741276.A0A2S5BG69"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30801" checksum="DFA1CDA55680ED60" modified="2018-07-18" version="1">MSLLRSAARRLGLGKFRYWQGTDLQGNNFFERPHPEYPDEWRKNKRYVEYYETKPLSDYNYQSIPVQWSAWLRRTRREPPTLEELQKDYHRQLRLQENVQRLEQEYQAEKLRLAASNESNLLKAPAVDRSRPARGVDADSPAQVLDASAKKGLPANEGGVDEATAARAPEIAKNLGLDRRDALEPGREALEGIAPTDASPAELAERRRKQDEAEAAARRAEFGETLVCRAGLAERELTMHTPTAQQNEPFKGKEAGSQEPAGWAPSAPARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGE6</accession>
    <name>A0A2S5BGE6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGE6"/>
    <dbReference type="STRING" id="741276.A0A2S5BGE6"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="57"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="549" mass="59445" checksum="84A0088648C0743B" modified="2018-07-18" version="1">MATTVTPAQERALKPRRGLGKYGMIFACGTALFGGAGERSGAEAVAHCPPLTRQQALSIQSSVGSTPSSTARITVGRRLFEREPWRDLKLMAFSADSTLFSGMAYLGTIIGQLSFGYFVDRYGRKYGELAWTRAQNVQNLTPGLFTGMLAASTIMIVGSALCAGAYGAGGSTEGMFTALIVYRLITGIGIGAEYPSGSVACSESTENSGVNPRWQHGLFVMATNTMQSLTSLSEQAAFVPLVLLWIFSEDHLRAVWRLTFGLGIVPAALVLLWRLKMPSEPERYRKSAIQKNVPYRLILKRYWRSLLGVSLCWFLYDFITIVNIITGGSDKLSTVFVWGVVINSLYLPGVLVGSLLVDKIGPKKQLIFFLCLQGITGFIMSGLYERLTKKVAAFAVVYGIFLSFGEAGPGGCLGLLASKSWPTAARGQMYGVAAAIGKIGAYVGVWAFPAIIADFPEGPKQTSGPFWVGSGLAFASALIALFLIPEIPTDGMTLEDERFREYLALNGYDVSQMGTHSELSSDDLAYEAEKPTYADMEQKAAGRNTYRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGN2</accession>
    <name>A0A2S5BGN2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGN2"/>
    <dbReference type="STRING" id="741276.A0A2S5BGN2"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="153"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="387" mass="43173" checksum="41E43D34D9A570F2" modified="2018-07-18" version="1">MSTHTCRWGILSTGWIANKFTLDLLVDPQTRQVSDVKHKVVAIGSRSAESAKRFLDETWKEAGVTEGKDTVKLYGSYDELLKDPDTDAIYIGTPHSHHYANVHAALTAGKNVLCEKAFTVNARQTQILIDLAREKNLFLMEAVWTRFQPYAYKLQEVIGSGAIGEVRAVQAELCVDFGPTAEKQPDHRIVNPYLAGGALLDLGPYPWTQLALTLLPRSKAAKEPMEVPKVAAGMTRTTSGVDASVVASIGFKQEDGRVVHGSFITAQDRQTTPQRCVLVQGSKGYIEVAFPTYRPRSFTVNSFDSVEHLADLDARPKTETFEFEPRPGGIWGFGWEADEVARCLRDGKKESDRMPLRETLLMMQVFDEMRKQGDFVYPEELETLELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH28</accession>
    <name>A0A2S5BH28_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="8">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH28"/>
    <dbReference type="STRING" id="741276.A0A2S5BH28"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 8" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="398"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="572" mass="62006" checksum="8E84B4EF4EED7E76" modified="2018-07-18" version="1">MPSQGYHEAKIAFVSDLEGGSVTRINLVCATAISTYAMWIYVHERVLVKGSKDSLRTPLTEFSVLILPLLLALTAFASTYGAAALNVVFVLAGIACSCLPLPPSSPPLSPSLERKPQLPSGNDVARTLFSQPFVTTYRAIMMVMTVLCILAVDFPIFPREFAKAETWGTSLMDLGVGSFVFSLGLVSALPLLRRALSLPSPTSSSPALSTSTSRGHDQDPSYLSTIWTSLRRSLPLIALGMVRVIMVKGVEYPEHVTEYGVHWNFFFTLALLPVLGAGIERWFFVRAIAIEDPDNSERRSFKVDMHAIALGVGIVNQTLLTLTPLQRWALTAERTGLISQNKEGLVSLPGYLAIYLLGLATGLYTFPPSPTFFRTLTTRLPRSAPSELIQKLDAKRDKVLGRRSSSDDPPSRRGEKGGQGGASSAVARRNAGQRKKAEWLVSAAVWWWILYGIATFGVGARVSRRLANLTYVVWVAAFNSTFLAAYLILHLTLVGRASGKADSMGSAPAIFEAINRNGLVVFLVANLMTGLVNVSLETMYASSSLAICVLTLYAAVVVGCAWALRGKRVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHD4</accession>
    <name>A0A2S5BHD4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHD4"/>
    <dbReference type="STRING" id="741276.A0A2S5BHD4"/>
    <dbReference type="OrthoDB" id="2524665at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF5">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="106"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="174" mass="19131" checksum="5CB7D92473D6145A" modified="2018-07-18" version="1">MPRLSRLFATISRHRQPFASPLLQTRNFTLGTRPNMVAVYANGTLLADSSATKVVEGNHYLYVLHVPLSPLGGAQGVIGPSSPTIPNISADRSVAASTDYAVRLSPPNDVKKEYFTSSKTHTHCPWKGDASYYNVKVGGDVITDAAWYYPQAKEKAKDIEGYVAFYKTKVKIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI42</accession>
    <name>A0A2S5BI42_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI42"/>
    <dbReference type="OrthoDB" id="2525973at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="307" mass="33407" checksum="1260812860A6615D" modified="2018-07-18" version="1">MAARTQYQRKAAARVSYAPPNESDASDDEWGGGASSAAHKARKDAPQADESDSGDATAEPSSGDEFRLGQARKRKAKKPRKKVKRTKQADEKAERAPKGKKRVGKLEAVTLVPTEVLLEIFSYLGPGDLLSLSKVSKSYRSIVTGDKSQSLWRRARAKYKLPDVSGGGFTELQYAEMMFGKGCTNCDRKSGTMDFYLRSKLCSECRKASLVKLEQLAKTHPNGMLEWPMCDTGAPSSGTSSTNQSPRSPKMIVLAADAETYKPRAPPAELVPVVHYANNLFNASRTLKPTPMMTNLPMADAVASNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI43</accession>
    <name>A0A2S5BI43_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A/B superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI43"/>
    <dbReference type="STRING" id="741276.A0A2S5BI43"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="278" mass="30101" checksum="116A71DE341A9417" modified="2018-07-18" version="1">MGELSVIPVQATASHPAPQLQQVDRKLRSEYSRPRDGNVESNLLILLHGLGDTAKPFAHLGQSLNLPQTAVLALQAPARIPLLEEEAYQWWDSFDHLGEVIQNPNPTETLALLTKVLEHLVAPPTAVPPGCGWLPSQIHLFGFAQGASCAGELALAWSRSRPAAEHLASLVSVSAPLLSHPTLSTPAATKVGLVFRSGEERATGAASWRKGFKDVREIKLPGGRGREGMPRGMDEWRDIMRFWSEVLIRRSALEFGKDVYEVTGGVAAAQQAGPQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI63</accession>
    <name>A0A2S5BI63_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI63"/>
    <dbReference type="OrthoDB" id="2520339at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="479" mass="52230" checksum="D89BFA497E605D81" modified="2018-07-18" version="1">MATDSNAHAVPAMGTGPSRRVASGEAEKTSISLLHLPVELLSEIVAHASDPDSTSVLARLTRVCKRLRPIVEEALYREIDVDQDTGRLALITRTLLDRSTTLILIHKLRIDMRAFGHATQIDESGARESQPATSSPAAFFGSLHFPLLRRLALVSVNPILLTDLLAAELPSAAPTLQSLYVHICRHGGDPMTEWFSYLARLPLLRDLELIAYESNLILPLESPELVPLLQLASAHIPGDIVCPASSATVSRLMPNLMCLSVENGEGAALRHIVAGAPAGLTSLSLLEGDDIAIEDYLARFPLLETLHIGAGFNPDRLLPLLTSSQIARLGFDWHLPATYDFLLAIVTGPQRMPRLRSLTLMHADCGAAGSHLQEVLENLNDATPDTIQARVSSLRGDYEPNFQPGCTAAGLARVLRSATANGINVDGQALECIDWNADFDRRLEQYFVEQAVRTRTLAVMERYYGRAEAAAIFARFRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIH1</accession>
    <name>A0A2S5BIH1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIH1"/>
    <dbReference type="STRING" id="741276.A0A2S5BIH1"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="5">
        <location>
            <begin position="68"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="534" mass="58464" checksum="18F03B3DFB58AD78" modified="2018-07-18" version="1">MFPRARTAISCASRRPMPTSASASTASLRTSMLANHLSTSSPAQSAPAATSPEGNSAVVTFEAVHALRRVTLNRPKALNSLNEDMVSLIQPQLENFEASELANIILIKGNGKHFCAGGDVVFITKTLDDPKTWRNGSDFFASEYKMDQFLATTPRPVVAFMTGVTFGGGVGVSGHGAFRVATESTQIAMPETKIGLFPDVGANFLLGRLDGQLGLYLGLTSFPLKGAANYFAGFASHYVPAERLPALEARLAELDVTATHETVNAAINEFAADAEELQRGLKDYPLVGPIRRAIDAIFARPTAENIMADLGALEQGSYDMSKIVLPQDGDVDMSAIQKWAKETREAISLRSPTSVKLSLKAIREGRKLTIDEVFRMDARLAAACCNPEVHPDFLTGVTDLLIRKIKPEDQRPAWKPATLEEVSDKHIQETFFAHPPPFKNPPVPQLDFSRKNRPGAYAAYKISPHAKWALPSEREIEKIVKGEDAGSNEFAVTKQEVVDRLLQRWNGKVGVREKVDEVLRRKTIVAEEQTLKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BII9</accession>
    <name>A0A2S5BII9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BII9"/>
    <dbReference type="STRING" id="741276.A0A2S5BII9"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="67609" checksum="BFE15B113D40BB09" modified="2018-07-18" version="1">MSPEEPATAVDASAGEPTAVEHAPADSRTSITRDEHAEPTQRASAEQSRNSTDAAPTPEATATPSAASAPVAATPAAAAVAQTPAAPAVSAPAASEFAHAALKKFKLVFLGEQSVGKTSLITRFMYDTFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDVTNRASFMNTSKWVDDVRSERGNDVIIVLVGNKTDLNDKRQVTTEEAEQKAKELNVMVIETSAKAGHNVKTLFRKIAQALPGMDSPNEAQTGANQMIDVSVTPTNTTENEGGTAASLLYPTYASYKALRPAASVGRTPADQAADLERWLMFWCVMGCVAVYEQWAEWGISWFPFYHEVKTLVVLWLVLPQIQGATYVYINHLSPFLTSHEGEIDQAMTNARASATKMGIEYLNRALRQARAFLLGNLFADPNAVGGATAGGVEHPTPDRPPVLAEPALMSGQQDAHAAAVSGLARFAGGLLRQYAPAAIAAGNVLLQPMSRTATTTTTTAGAGATSARAPPGGDTGSEQRRRTNAGRSRREELEAELAALREQDDSSGSATASGSEADSSSSPMGSVKGVGSLSFVEIAEAEAREYAAAATGATPKGPRRSGSWFGWGGAAANASSPADAAKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIL1</accession>
    <name>A0A2S5BIL1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIL1"/>
    <dbReference type="STRING" id="741276.A0A2S5BIL1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="60304" checksum="E93484F8ACD030C6" modified="2018-07-18" version="1">MGQSQPRTAGPEDDSAGTSPGSDRPVTSQGSATNPPPTRRRRALVIGAGSSGLATIQQALEAGLEPFCCEARPGVGGAWRFDADPGPYEWHFGEDGEAHVFTPGESDVKGRPTPSPMYASLRTNVPTTLMQYRGTPFPRTVGLFSKHNEVQQYLEDFAEPFLPYIRFDTRVVSVRHTLETDPYDDDADLGTEPRSSSSALGHRRWIASFRSTLRNDAPLEECQFDAVFVANGHYSRPYVPATEGLQDFPGERLHARWYRDAGQFEQKTVLVVGNSASGYDITRELADSIYTRRQAGVPAETLPRIYQSARSPPALGVPWDAPDAPEYSKEVQTFPPIRRIDGRRIEFLDGRSVNDVHTIMFATGYFFSFPFLSPSSAPFSEYPVTYAPPKPSDPSDSAPQPSAKGGLRIHNLDDRMLFYLPDPTLAFLGLPYLVIPFPLAQIQARLAARHFASSPQLPEPLRFRPNPAMAGSNGEEDGAPEIRGTVTLGHPKQFDLHDRMLRETGDVRDKEGREELGQAGGIWTLTSEADRDLRKGAKGLRKAVLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIN7</accession>
    <name>A0A2S5BIN7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial proton/calcium exchanger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Leucine zipper-EF-hand-containing transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_0231</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LETM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIN7"/>
    <dbReference type="STRING" id="741276.A0A2S5BIN7"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="15">
        <location>
            <begin position="229"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="636"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="456"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="690"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="708"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY76639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="736" mass="82041" checksum="363596E80AD57158" modified="2018-07-18" version="1">MAMPTPAGGMRVAFQSTRNCRGPTSSVSAASLPRLAPFVHARLAPSIYRSALASRAGPAGGVFGQQQLRLLTSSRPFLAPNPSTPTNADSATTPTKSADAVKEVAVQDEKKTAVAKKDSSKEKGTRMQRIWAVVKKEALHYYHGAKLLGKETRISARLVRKLIAGRKLTRREHRQLKRTTTDLLRLIPFSVFVIVPFMELLLPVALKLFPNMLPSTFTDKFREDEKKRKLLKVRLEMAKFLQETIRESGIKSPDKIKQSEEFKEFFRKVRSTGESPTTEEVVRVARLFEDDLTLENLTRPQLVSMCRYMNINAFGTDIFLRFTIRSRLAKLKQDDQVISSEGLDALSTAELQAACQSRGIRTLGVSEEHLRSELQQWLDLHLHYGLSGTLLILSKAFAFNRAYGAETEGGDEIMRSLKDTLASLPDNLVNETELEVSSDSASYKQRLEVLQQQEELIEDEEEQEAKEAESRRLKKEAEEEAKRLEAEKRSEAEEKVRAEAEKGQADAMLPESEIKEATKEAEAEPEKAPEDVRMTSEQVQELGSALEILSAKSAVVKERTELRRLIAENDKAETEEGGQPNPLNKRLKSLLTKIDAQLEEYDSSVGSRLNMFSTDHEGKIAAKDLRSALEVIAHRPEEKDIEVLLTKLDPDGDGWIPLDDILSLAAGEGLGILIEEETANSLQETAQAMKAEVKDSLPSSSAASTAVHDAKAKKEGGEKEKKEDKPKLRKEDVVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIU9</accession>
    <name>A0A2S5BIU9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0276</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIU9"/>
    <dbReference type="STRING" id="741276.A0A2S5BIU9"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="20"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="357" mass="37987" checksum="083ECA238A7F4695" modified="2018-07-18" version="1">MTAETVPKTALAIVFDEHDGPLRVEREHLVATPEVGEVLVRIAYTGVCHSDLHAWHGDWPDKPKLPLIGGHEGAGHIVAIGPGTKTPLKVGDAVGIKWLATACLDHCEDCLSGNEGLCAEQKASGYDLDGTFQQYVVSDARYVTPIPDGLALDIAAPLLCAGVTSWRAIKETNTKPGNMAVIVGAAGGLGHLATQYAIAIGLRVIAIDSGEEKQRMLAKYGVQDFIDFKNFSTEDALVEEVKRVSGGRGPHASVVFSSGAAAYNTALKYLRPRGTLVCVGLPANATLQAEIYTTVCTGLRIVGSNIGNRQDAIEALDFAARGKVKPEISVEPLENLHSVFERMERGEIAGRIVLSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ69</accession>
    <name>A0A2S5BJ69_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ69"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ69"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="216"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="549" mass="61728" checksum="A9BACA0B80AC7E5F" modified="2018-07-18" version="1">MHLLRPDPLLVVGPALTSAEVATATRVPPSHPDPAAFIDSLEDGSILRHFDFVARLDRRTSLTTSQIDPLRREGDDLADRTVEVLGLAEAKQRGKDVLVLMSDYLERKEAELGRLEWDRAKKDDVVWRLHDEMARDPPEGVTGFVFLGEDQAKVARRATPLDAFEQIEGPPSLAEGQAVFSRYAPQLYQAFGHFSLAGGFSAPKLAAVMRETNYLTSDSRDATHKRLLETSLFVLDAMADMTTGDSRGWRSAFRVRMLHAQVRIRIREGKARHNVYDEEENGVPINQADLLAVLGAFMISPVWSLRRIGISMTKREEAAYQVCWRHIGYYLGIKPEYLQRLYGSSFETAETYFASLAFALFPAGPPPTEPYATPQYKILSAIAGRPPKPTRVEHHLELCRLLLGPSLAEQLALPRGSLRDVLSVDFEIWTGWALLTFGSIYSRVPLIGRWRGRQWELTRRQWFQWVIELVVVWQLGERRTTFVWRDGEKHSLKLDATEGEEAGIEMGPKVGKAVKETWRNLLVEAGLVTGAVVALGVGAAWFGIRALRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ80</accession>
    <name>A0A2S5BJ80_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ80"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ80"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="47"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="262" mass="28191" checksum="3A5D1193E7755689" modified="2018-07-18" version="1">MPAIPGNGSTRRLRPIEPVLTSTWRRVEALAPREMLDDDELDEWEDEDEVEYVTLEFGSHLPEDVLNRYGELQLLGAESAHPIARVGHKHFQGVHETLIGNDLLFSHQPDGTPACVPWAKSSHRITFQPVRITRNPERAEGEGTPQNVAGTDDGYESDATPSGTGSGRGRGRGRGRGKKAAGPPVLGPDGQPIKRKPGRPKGSKNKNPRKSIPLGPPPQVDDDDDLYGDMALPIPPQPADDEALSMALDSAAEAEDGDGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZN6</accession>
    <name>A0A2S5AZN6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atos-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000155">
        <property type="protein sequence ID" value="POY70003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZN6"/>
    <dbReference type="OrthoDB" id="8625101at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="2">
        <location>
            <begin position="192"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="557" mass="59672" checksum="6F2539B52F16BF8B" modified="2018-07-18" version="1">MSRWSTPVEPSYAKTRRHSAAPSDSASSLSGSPTMMGTSIPTEPIPISRPGLGASYSSSGSSFLSPSRALDGPLHTLLPALAIEDRVSESPRDPASSVLEPTKSLKTARRLSGFSAYLSSPPRSSPLSRSVAEIDESDDDGSPRRLRAAWPVQPTLPPQTSPSERWPAKPRKRRSSVSSSLFGSLPAASNPFVGSFEDSLLHSRMSAPPSAPLNFVASIGVLGSSDLPMSRRCPPHIHVPFPAVFYASPGDPRATPYVGTVDLYTHYLRMLDTPTDGEQARSSKVPRFPGYPVPERGQVQVVLKDSNETAFRPFLVPYDLTGLDQEGAGGRTFVRQKSYCIEQPDGTGRMRFAIHLNFCAPPLRKRARRGSTDSPTRFYLYQAIRVVFASRGSETSDEWRVVTDGPDAPAAAHSRTPSGTFAAYHGPPHEWVMARKKAKERAKASALARLEASTSTLGASRPPTPPPQTPSMLSSALSIASPAPPVVVPTTAFSPGAPTFAHLDHEHAVGLSFDRVPSPAPGLSERPSLSALSALRPVQQDGAAPLPLSVERERCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZU9</accession>
    <name>A0A2S5AZU9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M16 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000151">
        <property type="protein sequence ID" value="POY70063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZU9"/>
    <dbReference type="STRING" id="741276.A0A2S5AZU9"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="2">
        <location>
            <begin position="208"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1052" mass="115948" checksum="027831098D49CBA5" modified="2018-07-18" version="1">MVAAMDVDMPQQVGDFRLIVDDELEFAKGIRIAKWQSESTGLKVVYGSNESPLVQGYFSVVTEIQDDTGRPHTLEHLIFLGSEKYPFKGILDTIANRSFAAGTNAWTAATDTTYTVATAGEQGFLSILPVYLDHILYPTITSEGFVTEVHNINGKGEDSGVVYAEMSGRENGSSDLMQLRLQRALYSTKNGLRSETGGLMEALRVLKVEQIREYHASMYVPQNITLIVNGRSLDPTKLLTTLTEHVIPSIAAHGQAHGRRPDGWVRPFVESSTASNPPQLPTDRTEIVEFPERDETVGELMVAWIGVPHNDFLNDLALEVLGVYLTDSAVSPLSKEFIEIDEPACTDISFYASSENPTVICAYLASVPIEELDELSARLRHTLGRIADDGIDMQRMASVLERQKLQLYESMETDASDVICNAVVADGIWGAEDGSDLRGSLKMTSLYRTLDSWSAEEWAAMLKRFFVDAPALTVVGRPSPTLADKIKADAKALIEKNKKHYGPEGLAKLQKEIEDAQAKNDIPVPNEIIRKFPVPDVDGIEWIKVETARSAGIAADDGVHNQVQDHVDADGAKLPLFVQFDHINSAFIQVSVVLFPQDVPGSDAAALRALLPVYLDSFFTLPIERPDGSVLEFEDVVKQLDAETLSYSINVNSPLQEGITLKVKVAKEKYDVAIRWIRDLLYHSRYTPERLKIAATKALQGLPSEKRDGSEVSYNAYRKMISQDASTNIALNLFNRIDFFPAFLEDLKEKPDAVVRQFEALRRALTDPRTMRVQVKGDILSLKKPASAWLDDFEAIEPFPKDQLCPVRLSSEVMGSLGRQPAKKAIVYGISSIESCFAYHVAKGPDSRTHPDQPALTVARAVLNAMESYLWKFLRGAGLAYGASIHQDIESGLVYFRVYKSPDSHAAFLAARDLIDQLVAGKLEMDDLTIESAKSSLAYNTAEKEATINAAANASFTNLLLGLPPNYGRKHLANTKDISAADILRVIETWIAPIFRPETSITSIALGLAKMDEVVKNFEALGYEVDQRTFEDEEGSDSGSESGSYTSGSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZV4</accession>
    <name>A0A2S5AZV4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_6943</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="PJQD01000151">
        <property type="protein sequence ID" value="POY70056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZV4"/>
    <dbReference type="STRING" id="741276.A0A2S5AZV4"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053974">
        <property type="entry name" value="ERMP1_1-A_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22249">
        <property type="entry name" value="ERMP1-TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="586"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="16">
        <location>
            <begin position="175"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1/1-A TM" evidence="17">
        <location>
            <begin position="445"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY70056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="949" mass="103503" checksum="26E2E646BC6984B1" modified="2018-07-18" version="1">MAEKNGVRPDGGPVTVKAAVPLPAAATSRSASTRRRLQPAPRQWPFSAFASVVFPLLLLLGYISVHLHYELPTPNAAEFGLQGEPTFSEVSAMRYIRDLAQYADGTPKYRIVGTKEMVETDNYIMAEIAKIREEVVKRHPQGGMQVEVFHQIGDGTHLFDFMDKKVWKKYFGISNVIVRLSDGTQASKANAVLVNAHSDSTLPSPGAADDLVGVAVMLEALRVMGMGERKLTNAVVFLFNGAEESLQDASHLFITQHPLRETIRAVINLEACGTDGKEIVFQATSPEMIRALAKTPSPYATIIASEIFKTGLIASDTDFRQFVQYGNLTGLDMALVQNSYRYHTMLDTADAIQAGSVQHMGDNVIALLEYLTSPETTMGNSPEATPILQSAPTSHTIFFSAFGGKVFVVYSRATATLAYGILAAITAVVVSDRVDWSHDGRAYILAVIGVLGSMVASIASANAVAFLTSYALGKSMSWFRQESFPLMLFGPPALLGAVCWQYFFVANRVRSPIATIAQDAAESALLEHASLVGQTIYNTGLTLFAHSLGVGSAYLFATSALSNLLALIANDYFLRRDPRGLHLFTYVIGESLPLLVGVEGMIGFLDLFVPLTGRMGADAPVDYIIAILVGALTLVALPMFLPFCHRWGASFTARLLVFLGLASTISTAWFMRPSWTQYDAQHPKRLLVLHMENTTTSPPEFHLHVASVDGIPFYDLVESATHGLTAPGSVPEPTLADDLSVDWDVIYPVSQFLTTYRIPLPAPPATYASPWLDTFEVKVAQIRLNAVKQTKAIDLVLHHPGIMWPVIAFDADVVAWDLPEPPQRGLIRHHVKSVASYGVIEFPVSVTVQLNPEQFAAAIREDQRAKGQRGDASAEDRAMSALRIDYSGLDVHGMYPASVQSDDAEEAKRRVLARDTKPGMIFFEKMFKRLEKEPVDAMLLSAVAGVAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZX8</accession>
    <name>A0A2S5AZX8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_7005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZX8"/>
    <dbReference type="STRING" id="741276.A0A2S5AZX8"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="582"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="638"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="816"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="816"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY69961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="874" mass="91629" checksum="9350F9DCA5F6E9DB" modified="2018-07-18" version="1">MKAKVIEIRWNDKQPIYSTDFHSVVPVQHLKKAHPYAHEQANEVQDEEKAWRLATCGADNKIRLWLVHPRPVSGPAVTAASLLAAVARSSSAGPDSTAPLASTSTAPPPPLPPSAAAGKTEPKDLDPKVEYLATLSQHQGVVNCVRFSPNGDALASAGDDGNILIWVPGEGTKSFGETTATEDLAFEKESWRVKGMIRCAHEPGSCGSGREADPVLAPRLNRSLSGKEIYDLAWSPCGTRILAGSVDHTATIYCTQTCSPLYRLAEHTNYVQGVAWDPRGGYIATQSSDRTMHVYEVKEQQAGQVEVHAVGRNSRMEVAVPVPNGGRPSTSRSSSATRPTARTLSTGASAHKSSDPAPRPSMPSRTHSAARSDASSSEASSSTTTAATSTQWPAPKPSSTSERGRARSASGAAGSVEEITTSMDPPQGIPHHPPAPSPSPQLGPTTGRSHSRRSSASGSATGMSPRATVSSSSSRPLRSPSPAPLPAVMPAHSPSPRSTETPAFASSSAGDTLAVRTDSVKLYSDANSTHFFRRLAWSPDGALLLTPAGLWEDPYAAASMQAAVASGAAASRATSGTTASTTSATTASTTASEPKPTVYIYSRSNIARPPIAHLPGHRTTSLGIRFCPVLWQLRDSDVPARGRRPSSRRGSGARAAEEEDREQEVDEEEEENAVSVQLSTDGVDVPLGSTTSAAASEQDKGKGPEVPSGSTRKPKSLFDLPYRMVYAVATLDSVYLYDTQQAGPLAMFGNLHYAPFTDLTWCALSPDGETLVISSQDGYCSVIAFEAGELGTPYVDEEGVLDFALPRPVAAAEPPAAPAVAAPARPTETGTSNVGPQIGDKRDASSLALATDASGEPAPKKVKKRVAPTLLTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0S6</accession>
    <name>A0A2S5B0S6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000139">
        <property type="protein sequence ID" value="POY70271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0S6"/>
    <dbReference type="STRING" id="741276.A0A2S5B0S6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="130" mass="13258" checksum="82AEBF9ACCF98E2A" modified="2018-07-18" version="1" fragment="single">SLALLDSALGSNKRERQPKLPKQQQQQQQEEGRGGDIAPASKSSAPANGGGVTKAAAAANKKKGGVSAAAAQAEPAAAVAADPELKKRLKEEEEKKRKRAARFAGPGSSVSSSNEPAEKKAKLDSDATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0X8</accession>
    <name>A0A2S5B0X8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0X8"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="100" mass="10629" checksum="C5FD8E1DCF2180F7" modified="2018-07-18" version="1">MPPRAPTPASTRPPSRPLSPSLGRTRAVRHQTRQRSREGAQGPGPADRSGTGKRRGRTGGTSCSSSRMPAWTPSRTYSGRTELCTSNLSTSSMSGLSRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B104</accession>
    <name>A0A2S5B104_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B104"/>
    <dbReference type="STRING" id="741276.A0A2S5B104"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="105" mass="12171" checksum="AB617DDE1A25BF99" modified="2018-07-18" version="1">MADAEMADVKPHIDAPKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQGAASNEECTVAWGVCNHAFHFHCINRWLKTRQVCPLDNREWELQKYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B157</accession>
    <name>A0A2S5B157_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B157"/>
    <dbReference type="STRING" id="741276.A0A2S5B157"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF95">
        <property type="entry name" value="CYTOCHROME B5 TYPE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="179" mass="20305" checksum="F00EF8FE2C893EAE" modified="2018-07-18" version="1">MGWISAQTRIRPSSPASEAAEAQKESTKPEFEHVEHVAGEIGAERRAQRASQGRRHRGLQPSPPPEDLAEAAGGRESVDPDHPPFIAPEVVAQHDNAIDGFWIIIEDRVYDCSDFVDLHPGGPEVFSQFGGKQCTWQFWRWHTRRQLEQWSPSLLIGRTFPVPPNPYPEPRRWIKTGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1F2</accession>
    <name>A0A2S5B1F2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1F2"/>
    <dbReference type="STRING" id="741276.A0A2S5B1F2"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF51">
        <property type="entry name" value="LD01482P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="2">
        <location>
            <begin position="143"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="398" mass="44511" checksum="2FE36103C5C6BB10" modified="2018-07-18" version="1">MAGPFELWLTPTITLSLVLESESDVPSVSRFVSQWLLYLRPALVRQALAYELEQRPDAEIVSAGTLRIVDYAYWRATRAKAGSLYQPVPSSSLAYDIALIEGVQVPSVEHDLLVTALDRVLHTYAIAEEAQALADQAFLEDGTNDDQLRTLWLELKPDQPLPGLTGKHWQDVRRFFDLTTDTRERSDLSDKVCSSASSMSRSDQPQGPCEGRLETDDVSRRNVAPSTDFRGVGYLGLKALLYFSHTYGERAAEIVHEAVEGGDRWYPFALASIHMTAFALELATSRDLQLFLLRSVQTRPLVSSSSIAPSDSAVESTDGRAAPNARSVDVDLEPFLRIASDLLLLFHAHWQQGSYTVMQFEQVEKGFRASLRPWIRRGILDGRALGWERRDEGQVKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1M5</accession>
    <name>A0A2S5B1M5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="5 14">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_6333</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="5 14"/>
    <dbReference type="EMBL" id="PJQD01000110">
        <property type="protein sequence ID" value="POY70660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1M5"/>
    <dbReference type="STRING" id="741276.A0A2S5B1M5"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="723"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="760"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="55"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="809"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY70660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="838" mass="92409" checksum="877402C8FBB00E6B" modified="2018-07-18" version="1">MSRFFAAGRRTFTRRPILTATAALVPTYLTYSALRRPSEDQDIDAQSLYYGGANPLRMEADGTLDRPSTMWTPPSREEMLQKLGCPPTKNASTKSHASGTDDDVAQQDSRGVRQQQGQQDSGRTKSTNEPPSVQPGQTAGQSAGQGDVDKDDDEFDLLIVGGGATGAGVALDAASRGLKVGMVERDDYSSGTSSKSTKLVHGGVRYLQKAVFELDYEQYKLVREALHERKTFLHTAPYLSHSLPIMLPVYTYWQIPYFFAGTKLYDFLAGNANLESSYVLGKGKALEAFPMLKSEGLKGAVVYYDGQHNDSRMNVALAMTAVQYGAVAANHCEVVHLLKDADGKTKGARMRDVLTGREWETKAKGVINATGPFSDGLRKMDDQKVQEIVSPASGVHITLPNYYAPAKIGLIDPATSDGRVIFFLPWQGNTIAGTTDSPATVEQHPIPKEEEIEFILNEVRGYLSGDVRVRRGDVLSAWSGLRPLVKDPNAKDTQSLVRNHLIDVSPSGLLTIAGGKWTTYRAMAEETVDRAIKEYNLKPDRGCITKNVQLVGSQGWSKLMFIKLIQQFGLEVDVARHLAEEYGDRAWGVCSMAKPTGLRFPVHGTRIDPVYPYIDAEVTWACRREYAATAVDVIARRTRLSFLNSEAALEALPTVIDIMSKELGWDSKRQDQEFRDATRFLTSMGLSWKRLENLTLADVREGRHREVLAGDDDYLARTVFSPGELKTLRKRFAKIDADHDGTIAADDLRKTMNKLGFDKVDEKTVKGVLSEVDSDNDGQVSFEEYLDVAAGVKEIHLHNAFTDVAFSDKATADEPQTEGSSKMDYSNKTPPERTGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1P0</accession>
    <name>A0A2S5B1P0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000098">
        <property type="protein sequence ID" value="POY70704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1P0"/>
    <dbReference type="STRING" id="741276.A0A2S5B1P0"/>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="68001" checksum="E82549EEEF4CC142" modified="2018-07-18" version="1">MQKPPVVAKTNERIAGPYLYRRRPPRSTRFPLTSNWSQLLPSRFLLLLGLVCGLVGLAQAQTSNLTSPSTTTVRLQSGESTLLNLAAPSTFPLYISLSLCSIPASLAGNDSFLLPADIAKPLYVSNSSSDPRPGPSSDPDSTGVPRGAKGDSSTLQFGYSNVTLLAAGEGNVTIQVYAPDVTNLLVGGDGRWSPSTVTASGPASESWVFELDISNGTQAAPYLAMSTISYRLEDTDASSVLLTATNQSEAYTPVISSATSLSYSLSRSRCYLRSMMAQNAATPANTQQSLTTRGYGPGQRTQMFVQGVRRNTTFTAWLVENVTMSDGSVQERMWDPVWFQTKSSSSCRLVYNMPACPSVAYAVPAPRSLGTDRLLSFFNDTISPYLANFTRTLTTFPCDRQPEGLFSVVSTCSDCADAYRDYVCAVTMPRCVDATSGTPLNTTVPQAVISGDVLASWTLPATYQTRLLRDEPFASRTPLFGPANLSNTFPFLFNASYPASEANLARETPFPYVEVPPCLDVCYLVQARCPFFLGFVCPKFDGSSPQGGTGAAAWGQTQDVSSTTRMANDVYGSALQKRAGDRWGTVYCNSLGSDLTMAVQFVDPFQQWPYEKPPPEVQPGPPLGRPPGSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1U5</accession>
    <name>A0A2S5B1U5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1U5"/>
    <dbReference type="OrthoDB" id="2522772at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="274" mass="29068" checksum="EDB93242FD8C6E2F" modified="2018-07-18" version="1">MLSQNDVLRLLSKPEPIPQVVAFSILHAYVYSKSRRGNLPSETLSKLLSIQRKLVTKLGYGFDASTPLGAALDAMKVQLMAVNRKWFTLGPLAFGPLGALGATGGNADAQWAWERATDGKVKDFPKGDGGGAMGWMPGGELDAGRVIDPTFGGPPPNVFPSADGMTTPDLLNAPPDYDDPPAPDSEVVQALEDRQRDDERGVVQSGRDSVDTQRLELARTRSGSVGNSFGAGSVATASKDPIGEGAAHLARLRALKEEREREEEASHSSSSKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Y8</accession>
    <name>A0A2S5B1Y8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Y8"/>
    <dbReference type="STRING" id="741276.A0A2S5B1Y8"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="497"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1080" mass="116746" checksum="7B30F4DA56C61C25" modified="2018-07-18" version="1">MAHALDLPSAPEPPPDPSTSTLISRSSTLRASPAQRAAPSGQLGSINGMYGGTGQDVLASTSRATGSSATMTSTDDGLIALTLLPNPPLPTDLAQYLTETSPLSPEQKRILFTAVYVRAASSGNADLLEWLLSLPNDPQLSTAENAANAKRFSLSRAKKRESQLSIASFAASEHDAAAGVSVDDDLPDWVARKWVDLDGQDGEGNPALVLAVAFGHSEAVRVLVESGAHISEADRAGWTALHWAAQNDDIPIAAYLLNHRASPLLVSRRGLTAKDLVRPGTEGLPMREVLSSAWEAAIERERALRRMNEAALDGAGKGKGKATQEEDPDPRSAVMSHSDSRVSLAALSEVDASTASWEDDRERERAEAKEREAMQRRLWQLALDCAEVLQLDLQLIGVRDPTARSGRDPPLLDDGESEDEDSVTQAQRPKFEWERCLADQMLVFSLSDLPLLLDVVISFMRPASIRKYRSTPANVVFLAARYAHYIGGSELFDELMFGVLERIENNIHRRPDDMAGCAFWLSNCLLILYYLRTEPNLAAATSDYQAHFADLINEIYVFIVRDAERRIDRVLDAAVLDHEPLPGFEDIAFEDEWASTRFVKKLTGRAKKGAGMRTSTSAMSLFSDTGSVSSADGLGGAGSPGRNRSTSTGNTPKDVTDILTATLYVMQLYELPPAIVIQAVSQLFYWLACEIFNRLFSQRKYLCRSRAMQIRLNVSTLEDWARTNRLSTKMVSGHFASVNQLLQWLQCLSSESSIDGLIGTVDTLRALNPTQLRRAVREYRYEVDESKINDDCVEYLAQVEKQWERQRLQQQQEPGQTGALADARGESDVRNPAADRVDAISGDPAALLNYVPPPAPEPSGELLNSRHMAKVAHSLRTPQLPFALPTGTHHLVDGGSSELAGALASVKLSGGVSSNGRSEPKTEARSVDDGSLATGSNSHEVASSTSVGGPAQEDPVDRIVPVLPDDFFAVLDVARRRAGRASGHSPSAALLAEGDMADAFKTPQLGSADPDAQEAPGRWWSGGSPARVSGMSPIAAGRNGSTRADRSASLSSGIGQDPDSSFESVGSVDDTPRPAFAFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B275</accession>
    <name>A0A2S5B275_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rossman fold oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B275"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29539" checksum="586A0B363D45D41E" modified="2018-07-18" version="1">MVASVAVIQGAGGSLGSHFCRHLLKQSSLSVVATSRDPSAARRAILEGLDGGDKLESRLTVLEVDATQEETIKKAAEAVKKEFGEKSLRLLINASGVLHADKSIASLDAAKMLHTFQLNTFAPLLAFKHFYPLLPQKNDIRSSDAAQSEQDPANGMVQPGLGVLASITAKIGSIGDNKKGGWNAYRASKAAANQTIMTLQRELSLRSTPSIALALHPGTVVGTNLSKPWTKPEDANKKPGHFDAETSTKMLLDVIAKSKQEDGGRFLNYEGIEIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2L8</accession>
    <name>A0A2S5B2L8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5949</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2L8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2L8"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="168"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="817"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY71024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="869" mass="95574" checksum="09A31E8072931684" modified="2018-07-18" version="1">MTTDADQHQNGPPSSLTALGQQLHSLACRDDKISPVPESAPSSPVKPQQVQAVAISPPGYSQLPSATQKRTKAEIERKRDEALERRRQKEKDKSAADRQKKREELAAQSLSKFGFTIASAGISRYGTGRGGFDVKDEPVLAKEEKPKIWEPDTRCSDEQKAVLEEVKAGRLVFFTGAAGVGKSFLLQEITRLLEYLQRPFQITATTGIAALQVSGITVHSWSGVGLGKDPVTVLYDRIMRSKERVKIWTTTEVLVIDEISMIGADLFTKLDVLGKLIRRDRRPFGGIQLVVSGDFFQLPPVPEPRNELRCMRCGHHNLQKVALHDACLPYEERAKGVPPDEVLRCTDIVKRNGEKISGCGSEWRTRRFAFETEAWAECAFKVMELTKVYRQDHPAFIATLAKIRRGICDDECTAFLKTCGTELGKGGNIKIQPTNLYPIRSAVENENRREFEKLREEAYTFQALDDSRGGYARTVMAERLANVPPAKSLALKKGAQVLLLANLNIKQGLVNGSRGVIVDWVDRDLVPLDDKLDSTQAGTTQKRKVAGGAFGGEEWREKAAEEWADKQDAEVFPLVYFATGAQVIIRPHSWCIDIDKENTVARTQLPLQLAWALTIHKSQGQSLDAVGVRLNATFEKGQAYVALSRCRKPEGMKIEGFHPGVVMAHPTVSIFYDCIKEGRPFFVTPFTYLNPLSFVQDFDPLLLSLTPVFGKPPAAPPAGSAILAPGQKPPVGVKAPPAVLEAAAASTLNGALTSLAEDSTTWENLLERAAERFLASRERREGAGALPAPLDQHGQPLDETSIFTAQAFRTVTSLIGKRKAADDEVDSSRSPTPPPGGPGGVGTEERDSQTLDCKPKKPKRKRSKRRVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Q3</accession>
    <name>A0A2S5B2Q3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 19">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="6 19">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BMF94_5995</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 25">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="19">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="19">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Mitochondrion inner membrane</location>
            <topology evidence="2 19">Peripheral membrane protein</topology>
            <orientation evidence="2 19">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="6 19"/>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Q3"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Q3"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="17 19" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="9 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 19" id="KW-0408">Iron</keyword>
    <keyword evidence="16 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="20">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="21">
        <location>
            <begin position="106"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="22">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="POY71068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="336" mass="37932" checksum="D978BA8A99A5AA7B" modified="2018-07-18" version="1" fragment="single">ANSGPHTNGCQFFITTEPAPFLDKKHVVFGKVIGQDSMLVVRKVENIATGPNNRPKLQCVITVTPTMLSTTSFARAALRATPRARVNSQSVRALATAVDSKPENLKTFSIYRWNPDKPAEKPYMQEYKIDLNKCGPMVLDAILKIKNELDPTLTFRRSCREGICGSCAMNIDGVNTLACLKRIEKDQKELKIYPLPHMYVIKDLVPDMTQFYKQYKSIQPYLQADKPADGREHLQSKEDRLKLDGMYECILCACCSTSCPSYWWNQDQYLGPAVLMQAYRWVADSRDTQKAKRLEQLANPFSLYRCHTIFNCSKTCPKGLNPAKAIASLKQEMASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B382</accession>
    <name>A0A2S5B382_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B382"/>
    <dbReference type="STRING" id="741276.A0A2S5B382"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF4">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015602510" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="2">
        <location>
            <begin position="117"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="392" mass="43882" checksum="B9E471E89C11B625" modified="2018-07-18" version="1">MKASTFALALAALASSAFAHDDVSNSPERIKYLQSIEEKMYACGPKIAKYQALRKRTTQHVLNGGAAPTDAKDLFVDGGEDSATEASHISKTLLAHLTEEPKIQNHSCILAPMLTEGPYYHSAGHPIRQNMAEDQLGFPFFMDVGIIDVNTCEPMPNVLVDLWHANTTGHYAGHPDQEAHLKWEGPATDGPRKGLLTKYPRTNDHETFLRAAWPTNDNGLAQFSCESRWRLIFLWRRRTTDTPADFMPRPPIVAIFPGYYTGRATHVHIRVHTEWEPLQNGTFLSNRMLHTGQLFVPDSINMQVDKMFPYNLNPIADKWGRTRNWADSLGIYHDAHGNGYNPEFELVKVGAVLQQGLIGYITVGVDSKANFDVNAPWKPIPDNVAARLNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3F8</accession>
    <name>A0A2S5B3F8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3F8"/>
    <dbReference type="STRING" id="741276.A0A2S5B3F8"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="402" mass="43793" checksum="6141ADA51AF36BDA" modified="2018-07-18" version="1">MGRTKSRSKKASKANAFPAAETAPAASTSAPPPVVIKVEDLLVKAAQQIGSINYEGAKALCLQAVELAHKEMQEQKEGADPRMLRDAFEILGTVELELGDIDDAREHFAASIQLASALPDPSPAPHLYLAQLAASPEESLSHFGNALTILQAKLAALEQAKLGTDGGAGTQDEAEDEGEIRRSASRALVGMTELYLTDLCFEADAEQKCETLLAEAAQIDPTDPEVYQTLASVRLSQQRENDAKEALHRGWDLWKDLENDSPQYPPAPSRLTCVKLFLELSEHVPALQILNRLEDEDDEDSEVWYLSGWAWWTLGESRGAESKDEEVESQAECWSESRLCLENYLRLEELDPSSTDPDQMGHVRELMSKLDAAGVVASGGADDAEGGQGAWEDASEDEAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3N0</accession>
    <name>A0A2S5B3N0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3N0"/>
    <dbReference type="STRING" id="741276.A0A2S5B3N0"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="496" mass="54929" checksum="014F25D01102C5BC" modified="2018-07-18" version="1">MKELPTYSEVGTTRRNSSWCSPRRLAAIGLGAVIGLQTLAAVKDSDTVAEAVYDTAVDVKWALTPLSSCPRKRALQLMSRQPVIDGHVDLEILSRWYYANDVEAFDLRKETRGQVDFPRMREGRMGGFFHSVFVPCPEDDGFDSQNQSNFTTPTWRVRDTLEQIDTARLLIDKYSDEFSLTLTAKEWRKAMKRGKFGGMLGVEGGHQIGSSLSSIRTYFDLGVRYMTLTHTCHSPLADSCGYVEHPSPDDLDAANAPLKPRWNGLSHFGRTAIREMNRLGMMVDVSHTSPKTASDALSHSLAPVIFSHSNARGVHSHSRNIPDAILRRIGSLNPSRRGKFNLSSDGEEGRGWGADSGEVDKPVLGGDVLIMLNFSPTFVSEWSDGSGLRSNVSLVADHADYIGRLAGREHVGIGSDFDGIDAVPEGLEDVSKYPNLVTELLRRGWSDKEVMGLTSGNLLRILEKVERTARKLRHEKPAYEIFEGRTDLVKHDSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3X5</accession>
    <name>A0A2S5B3X5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_5758</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3X5"/>
    <dbReference type="STRING" id="741276.A0A2S5B3X5"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16 20" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="32"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="265"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="669"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY71445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="858" mass="91164" checksum="6E8492ABF52F69F1" modified="2018-07-18" version="1">MAATTAATVNLQAVAGHDAASFPKIDKDNHVVMLDNYDSFTWNLYQYLCLLGANMTVIRSEALSLEELQAQHPDMTHLIISPGPGHPLKDSGISVPAIQHYAGKIPILGVCMGLQCITVNYGGVVDQAGEYVHGKTSPILHDGRGLFKGLAQGVAGTRYHSLAARINSIPDCLEVTSRTEGGIIMGLRHRELTVESVQYHPESILSDEGKLMLANFLSWKGGKWADMPDVLTPAASHVANAKSTLAPAAAAATSKSAPSAVPTILNKIEKQRILDVAKAKETPGYRPADLASLIALQVPPPLISFHERLRPSLTSTSTAPSLPTAQHVALLAEVKRASPSKGDIVDASSPSAPAIALSYALAGASVISVLTEPKWFKGSLDDMRAVRAVVDSLPNRPAVLRKDFILDPYQIDEARVYGADTVLLIVAMLDDDKLALLYDHAVQRGMEPLVEVNNAEELERALKVGAKVIGVNNRNLHDFNVDMDTTSRIADVIKDKYPERAGEIILIALSGITGREDVVRYQEQGVSAVLVGESLMRANDKGAFVRKLLGLESPHEAAATRSTTTSSAASLVNGAAAAVQSAASAVVNAVTGSSATPSRGPLVKICGLRTPEAAVAATDAGADMLGLIFVPKSKRNVPLPQAKSIIEAVRARHAHKSPDAVASAAALDPTDWFSFQASRIAAHPRKPLFVGVFQNASLANILHAVDSLGLDLVQLHGSEPTHWARLIPVPVIRAFHVDEKVEADLKEAEQLREATRPGYHALALLDTKVSHETGALSGGAGKAFDWSVARRLVGSRQTIGGSSEPLPIVLAGGLDASNVRKGIEMVRPFAVDISGGVETNGEKDLDKIREFIRLAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3Z5</accession>
    <name>A0A2S5B3Z5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3Z5"/>
    <dbReference type="STRING" id="741276.A0A2S5B3Z5"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="199"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="769" mass="85912" checksum="15D594D078146026" modified="2018-07-18" version="1">MVRIASLLRPVATLVQSATGSGQQQPSPSSPSGTPNMSTGSHARFHVLENEDSDEEDVVAAAGWTNKDRRNRPPSASESDGEGHDSLTIPLTAFRDDHADAHDPTDISGALPTPATRSNRRKSMPAKVVGSAFALLDRLPTRRVLAILIVIVGLYKISHYAGIRPSYSIVRTKLEEYSARYNPWHYGSRINWIDVAPVASVNGMRYRAHQEEEEDRYWAWKAIPYAQAPLGAKRFRVAVPIEQPNAGSKDKRAVEERVMDTWDDGCVRPRPREDRTDGPHEEFDGHEDCLKLNVFSPMQRPNSTLLPVMVWIHGGGFVGGSSAEPNYHPGDLLDRAIDLEQPFVFTSINYRLGALGLTASPPEPGAPPTAPHIPTRPASELDLNVAFKDQLLALEWIRDHISLFGGDPEKIVLVGHSAGAMSVGLHQIYSGDRNLFRGAFMLSGAPTSFPVPWPHDAAARTLHPLPGPAQCPSPVQREHGPPQNVDLMECLRSLPIERLYQATRTLTDDSPSNAWFPYYPVLEGEWQPEEGAEDQRRPWLDVRPSERITRGSYAKIPVVMGSVDDEGTRFVRPDIPDGQPEFLEVVKRVFDFTYGAVEELLEPILAFYPSDPKLGSPFFTGPETFGLSSNYKRLSSFIGDILFQAPRRHFLRETPKDFGEDSWNYLYREPRAGAQARFGIQHGADLPSWFGHPDESDDAMIQLSFEMTGYLINFITKLDPNGPGLPRWPKYGMDRLTQQFMRDNTTIVDDSDRLEAMRFLNINNPIFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4D5</accession>
    <name>A0A2S5B4D5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4D5"/>
    <dbReference type="OrthoDB" id="2519278at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24718" checksum="C859283195F687E8" modified="2018-07-18" version="1">MAAPPRLPVEMWTTVCDELGYRDLKAFGGVCKASQRLIEDSRYDRKLFREKPGRRLARGTKIAIHPMLDQINCLGQDPSKAEILAPTQPPEDPVWRDKPDFLCDPDYLNGFDYKAVDEFATAPACKKLHLDMAEIDCGTISSSTGVTVRQVAEACIKYWSSPVTGRQKKQFLEDNKGWYPPNSRVTRVDLLYDHCFFEGWSNARADSEGAAILSTYGFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4I5</accession>
    <name>A0A2S5B4I5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4I5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4I5"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="513" mass="53718" checksum="4419E53F7D894A67" modified="2018-07-18" version="1">MSMLAAVQEEPEEAFTSESVAQLAPAPSPWHDRHHSRVHSRNLSVFFPRPDQQAPGDPFGAGSRPTQSPPSPVDIRGPARQASPLTRDANGADGSRPAQRRGHHHRHSVSMQIPSPSTLRSTGVSNESQAGKDWSDSERPFPSHRNAPSDAPVSSSPRSSPLSWAVAFAQIAIGAFLWIRGQGLESLSTTGLGYLVVFDGAAVLLDVYVAGRIKRHAFRSSGTSLVAKQEPQARIRLPYGLHRLSTLSHFAQSIYLLFSAIYISKESIEHVLLLSSSGEQAGGHVHGHGTAAAGAAAIDGAAAGIRAAGITPFPVPLLALSLSAVLAGFLSIAARNHEALTSCARLDLSGASAGSRRGVTRTSAGPANPFTLALLGSTLTILAAACSLPPSLFAAFDKFFALLEAAIIFHIARPAALASAQILAQAMPRLGSATAQPQAWLHADSLQLPAVQDAKLSHIWLRNEASSSRSALVAVADVTLAGSASDAQALQVAESRPLASVELDLVVDVRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4S4</accession>
    <name>A0A2S5B4S4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5071</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4S4"/>
    <dbReference type="STRING" id="741276.A0A2S5B4S4"/>
    <dbReference type="OrthoDB" id="2536401at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="133" mass="13986" checksum="407C633A76AB5A2F" modified="2018-07-18" version="1">MSSGGKSGGKAGGDSSKAQSRSAKAGLQFPVGRIHRLLRRGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKSRIIPRHLQLAIRNDEELNRLLGHVVISQGGVLPNIHSELLPSKSAKGAASQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4W0</accession>
    <name>A0A2S5B4W0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4W0"/>
    <dbReference type="STRING" id="741276.A0A2S5B4W0"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="546"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="642" mass="69098" checksum="3BD6ED7FC123D18B" modified="2018-07-18" version="1">MQQRFNSGKVSGPVVGMDLGTTNSCVAIMEGKVPRVLENSEGGRTTPSVVAFTKDGERLVGLPAKRQAVVNFENTFFATKRLIGRKFSDAEVQKDLDNVPFKIVKHSNGDAWLEARGQKYSPSQIGAFVVGKLKETAEGFLGKSIKHAVITVPAYLHPANFNDSQRQATKDAGTIAGLDVLRVINEPTAAALAYGLDRNDSRQVAVYDLGGGTFDVSILEMQKGVFEVKSTNGNTHLGGEDFDITLVNYIVGEFKKESSIDLSKDRMAIQRIREAAEKAKIELSSTAQTDVNLPYITADASGPKHINLKFTRSQLEQLVGPLIDKTVEPCKKALADAGMKASEIEEVILVGGMSRMPKVIETVKSVFGREPSKGVNPDEAVAVGAAVQGGVLAGSVTDVLLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQTFSTAADGQTAVEIKVFQGERELVRDNKMLGNFQLVGIPPAPKGIPQIEVTFDIDADGIVNVSAKDKATNKDQSITIAASSGLSDKEIESMIAQAEAHAEADKARRDLIEAANSADSVAAETEKALNEFKEQVDAEEAKKVQGLITELRELNVKAQAEGSDVKPEDIKAKVSETQQASLKLFQKVYEQRNKDSSSSESPSEPPKEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B583</accession>
    <name>A0A2S5B583_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B583"/>
    <dbReference type="STRING" id="741276.A0A2S5B583"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="53988" checksum="E9C7DC65AB25CBA1" modified="2018-07-18" version="1">MPRPRSRSRSPHRTGAFGPHDRAATLDARDRLTTAALPVEIQVEIDRSGYYLGTAMLLFVVLLWILGSFLMNVMFTDYSYNKPWLATWLCTSSFSLYLIRPAIHSWRRKRRRRGSLTPLPFLDTLARVVSKDDEDEIDGLGYSRPSSILRSESRRSMSRTRPSRNDLGRHLPLVEPVEAPLTSQETAQLALMFCPLWFCANWAMNAALGYTSVSSTTILSSMSGFFTLAAGTCVGVEVFTVGKFLSVVLSVTGVVIVSLSDSSLPPPPTGEPRGSPGITIKSPTPSHPLLGDALALLSALAYAAYVLLLKVRIRNEARISMTLFFGFVGIFNILLFWPMGIFLHFLGVETFEMPHGRDLMAGLLFNAAITFVSDALYLRAMLLTSPLTVTLGLSLSIPLALIGDLVYRRAGEPVQLAAVLGGFLVLGSFVANGILDLQEAEKRAIDQVIDPLCAAIEEEEVERERLLLSGDEEAAAAVVTAAAAAVAAAAPRSRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5Q8</accession>
    <name>A0A2S5B5Q8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5Q8"/>
    <dbReference type="OrthoDB" id="5333491at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46854" checksum="76C7429E5185CA42" modified="2018-07-18" version="1">MPSPSLPASVIRCILDRFDAECEGEYARIHKILTISRVCKAWKPVAEQVAFRHVDMQVGDDRPFSKRLQLHLWTTSAHASHLRELDVDVILSSDSQQRRIALASFASLLVSLSAYRDLSSNKAHGLDSLSTTFTFDGAAVNLAELRVVSTALRAFESLRHLQVRADVVEPDAEFEDAGIDVMERAMEERLESSEDGFLEVDSLQIGNETAFGDEEEPEISFAFARSSVQLTALKRLLLLNVTRIDLPSWWDRLNRLEELEITPTTYSASRAVLEALLPILPRLTSLKRFYLTSLKLLLPFISPYAASQAKLKDAFGAVPLSELLAAVPPQCSLFQIDHLIFEPPQTAAMPRLIMSQNVPLPRLATARLLLRSQSTGRATLTVKQETLCRMMDLDGVATWLRMQEPQMTMTPATDADHGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5S8</accession>
    <name>A0A2S5B5S8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5S8"/>
    <dbReference type="STRING" id="741276.A0A2S5B5S8"/>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="6">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="921" mass="102871" checksum="2A7031A1AECB505F" modified="2018-07-18" version="1">MASLASLLEQSQRLQASLASSSSAPLSQPGIDLPAIQLGLDQIESQSRRIAGRSLKEAGQAGNAAYLLASGGVNAEQLSSNINSVNLAGTFEPLVPLSDTDIEASVLEDCPRLNLVDGEQGYIRHTHEQAIISAIEEGRRATTDDFYRNLDSKMRRDWEKQKEQLFEELGKHQPAAGPSNETSRRSAQTASFDRTPAVGTSFPSSGGSLQMHSKMMRYDRVIRRLNEFRKEGFAFGLVSALGEASVGTTAGDSRSTQTTETWRLLAHLVGERDVLNGEFQRTALQERQYAQAYLMSDAESQDAAGVRKMIGDGAREYLEEQFMTYVEKTIASRPAEAALGGVPSIQNKIRGFLNVKYQKNGQWSNQALEIANNTPVWARIYYLVRSGHAEDALAFATEHEGELQKLEKSFVSYFKAWLDSPDRRLPKLLRDRFLAEYNQRIRYLTDTSDPYKHALYKLIGRVEINRRNVPGVTQTTEDWLWFQLSLVRETEGQGEAPHESYGLRDLAAVLLKFGEAHFDPKGTRPLLYFQVLLLSGQFERAIAFLQQHSQYQADAVHFAIALAYYGLLRVPARGKSAEVEFLTDGKTATPSLSFARLLHRYTRLFAQSDAAEALQYLYLICLYADLKGPLGEEQVALAHQYVRELVMETRQYSQLLGDVRNDGTKVSGQIERDLKLLHLADSRTYLLDIVKSAAERADVEQRFSEAILLYNLAEEYDAVIAVLNVELGNSLSRPASSSDSTSSHQRSAAGAMSTIGMAAGQEDVAQVARSILEHYDRSASMSGKVSRKRRETCETLMRLKEALSAYERGHLEQALQAIESTNLIPLHSDLVHLIRAAEDVNSVDDAIVRNLDVILVATMTVLYKLHQQLKESPFGGDASRQQRMQEYRAKARSLMTFAGMLRYRLSSDTYSQLTRLDVFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5U5</accession>
    <name>A0A2S5B5U5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4789</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5U5"/>
    <dbReference type="STRING" id="741276.A0A2S5B5U5"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="425"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="509"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="641"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="674" mass="74238" checksum="56D75E6D66D1DE6F" modified="2018-07-18" version="1">MALVDYGSDSDAEQQQRYSVAGAGPARLPPVDPTPTDRDNNDNDDDDDEAEYNPQDAFGLARIEKEGGVGTDKAGKGTAAAAAAPSGSSAPQVIAANLASNNSLVTRPSDNVIYYNASYADLTRPVQGPANPWDDGKLEKQNALTGHVEQQHFSDLSFKEQQRSFQVLGYAANPSIAAQGSGAANQFVGNLQAAQQNAGTLVSDLKPTRAQTREMRRKRKAKGKLGEFDDPDDEEGGEGEGGAAADGEDGADDVVEEGADGEVRQVKRKKDKPQREYLGPWAGWEGESLAVVVPTEEEYEEQELAGGPLLNKQERRKKLLEEAGKRDIGFGEEKSVFHGKEERDYLGRTYLHVPTDVDGVNLRGEPGSLESFVPKKCIHTWTGHTKGVSRIQLFPKSGHLILSASLDTRIKLWDVYNEGKCLRTFMGHSKSVHDINFDPSGADFLSAAFDRQMKLWDTETGQCKQAFSNGKIPYCIRFHPDQPTTFLAGMSDKKIVQYDTRSGEITQEYDQHLGPVNTITFVDENRRFITTSDDKTMRVWDFDIPVPIKLIADPSMHSMPAVGLHPNGKWLAATSLDNQVVIFGSDTFKQNRKKRFAGHTIAGYACEPHFSPDGRFLSSGDGQGNMVFWDFKSGRISGRLNRAHKQVIVSHEWLPHEHSKLVTSSWDGLIKLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B605</accession>
    <name>A0A2S5B605_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UMP pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4874</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B605"/>
    <dbReference type="STRING" id="741276.A0A2S5B605"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000003">
        <property type="entry name" value="Uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="210" mass="22647" checksum="16F1AED53A84FEA8" modified="2018-07-18" version="1">MSVNLVEHPIVQAKLSQLRSVETSSHRFRSLVKELSTLLGIEASRDLPLKDLPGLKSPITEFTGKAIAPRIGLSPILRAGIGMTDSLLDLFPEASVFYLGLFREKVSLQPVEYYQKLPPSPTVDTLYLLDPLIATGGTAIAAISILLDWGLQISQIKVLSVLGSKPGLTRVAEAYPGLEIYTCGIDETLSEDGMIVPGLGDSGDRLFNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B606</accession>
    <name>A0A2S5B606_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B606"/>
    <dbReference type="STRING" id="741276.A0A2S5B606"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="10">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="336" mass="36815" checksum="466B6333856EFA29" modified="2018-07-18" version="1">MFRFVTPSSAAAPIASTSQQRLPTTTNAHRDMYDDGDDDDYDASATVHGAVTGPGEVIADAQRWMRGHGTYVQDDKVYASVAGTLERVNKLVTVKPLRTRYRGEVGDLVVGRIVEVGPKRWKVEAHASQNAVLMLSSINLPGGVQRRKLESDELQMRTFFQEGDLLVAEVQAFFGDGAMSLHTRSLRYGKLKNGLLVTVPPALIVRAKSHFHSLDPATIGVDLIIGLNGYIWISKSVKKETRLDGEEVGFGEESGEGVYSGENEDISPSTRRSLTRIALVISLLARHCIPLTIELITEAHDVAVRLVGSERDGLRRLANEEEGWEVLKALALGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B619</accession>
    <name>A0A2S5B619_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B619"/>
    <dbReference type="STRING" id="741276.A0A2S5B619"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="348" mass="36196" checksum="ED48EAB72C9435B4" modified="2018-07-18" version="1">MPARIMTSKAFQSRFGSKLPIVCPPMAGVAGGRLAAAVHKAGGFGYIGAGHKPFDTLVEDVRLAKETLSLSPNDDLPVGVGFMGWKFEPPQLEKETGINDGERWLAYIIHEAKARSVWISFANDLKAWVDRARAIEKAGSNGASTRKEKLLIAIMVHSAAKAKEALSWKNVDAVVLQGTEAGGHGADSEHGAPLDELLDAVLGDTSMSSDSRPLILAAGGISSPAAVAKYLGREGVAAVVPGTALCVADESTLSDPQKKLLVDAQDGASGTARSVRWDIARGTTGWPVGVDGRGLRDAVSESSGEVQKGGPPVTWAGTGVGDVTKTGPVADILQHLASEYRGETEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B683</accession>
    <name>A0A2S5B683_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B683"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="206" mass="24258" checksum="E5CA7F8A3A4BD22C" modified="2018-07-18" version="1">MSNPSTVAVFPFDRLPDELIEAIARWVIAADWDYARDRVRSHRRYCSIMTCIIHHYPPARREERARSKRDWRHAQSTRREIRTLRVVSEDSYEADERIERLANCIAGEVEDLHCSFQCWSGCSRPDLSYALVEDLIQRMSCLRRLTVKVDRDWPQDERKDDEGADEVDDDLAAYRSLLQYAKARQLERLEVQGAKAWLTTSQDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B686</accession>
    <name>A0A2S5B686_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4709</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000053">
        <property type="protein sequence ID" value="POY72266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B686"/>
    <dbReference type="STRING" id="741276.A0A2S5B686"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="655" mass="69661" checksum="1A807640A8F0AEDD" modified="2018-07-18" version="1">MQPASTGGGRMRSGTSSLAAAGRSGFHPPANRESFKDLLVFEERLKQNAERLQKQRRKYEAFLLTLSGVIAYLGYSVFVLPSIYSLVHYSNVAMLLVAATTLVLFFATGMYSEKIAYAHKFVPQANRALRPFNIYLNTRRRSRFVFVSRWFNSNPAAAAGAGAPLSRTSSIRSNASSTSTASSGGGGGGAPLSRQTSNASSASSASENGFRSPPASPPLSPMASPPESPSATASSRTIDLPSLPPIPTTTSSNPTPPTTASTSSSREAVTRALPVVNSTSSRQPVPLPPIPPSLNPRGELIFSSRVSPAFREGYERYRGEWERRRAEAKRAAKNAKKQQQGKGKQIGAAKASASGSGAGGTSWLGWGRGSKTEAVGTEAVGRMREKEIDLASQRHDDQSQSASTGDDDRPRDRMRFQSPTPPPPTSSPHAPDQLRPTPLSSSPPGRTSGRTAFRHVPLPRSDSEQSGASADESKRSRLGTARRRTPSSTDSGGPRLGGDAPKTSRELSRDSSDTELRAYDPDRRRHAAPNDLGIESASLGLTSSPTLSSSSLFSSGDDLDVDLHHETLRTRGGRSTSEHDAASPFPAEEGGPAAERSTIPTTATLSGAATRVRAESFSDLLTYEGEIDDEDQRGVLGSAARLPRLERSNSMRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6S8</accession>
    <name>A0A2S5B6S8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_4309</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6S8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6S8"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="394"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="520"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY72483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="736" mass="79046" checksum="DA2225EBD39AEAEA" modified="2018-07-18" version="1">MSRVLARRMPLHRTQPTPTLARSLVQVAPRRSYATAPTKSNVFPAPGPSSAPRGAPLPPPPPPKPRKSLTRRVLSPLLLLTLAFYGVSVPLGYFSLRYRDFLVETVPGGEQIGELLDEYQIKQAVARPEPGAAPLSKGKETELTRYAESRAQAEGWKVKKPAPSDPEQARAEIQKRLDAEAQKVKGKAADVAAAAKARAAGAKMTVEDAAAKVEDKVKQAGAAVVEAVSNAPHAADKAAHKTEAALADAAHKAKAAVARAAPSSSTTAVPASTPATPEVQSTLPLYAQRPRDVTADPVPPKQPAVKKETYVGPPLPIGFEPAPGFELPRAPPTPKGEIKPVAPPPAPLPLVAPALKDVTSSEPMLGQLASTIDSLAKYVEKEDATASASAANVLSGAQKDIKSLAARLEGIKKQEEDKLQAQLKEQASKYSGMLVKAEKELVERLDTQEEDWKKAFDDERARLVKAYKDKLDAELATQQELIDQRLREEVVAQGIELQRRWVSEIKMRVEQERGGRLAKLEELESGVRKLEKVAKENEEALGEAQRARKIFTAVKALEHKVESGQPFSSELATLQRLAKPSASEDGKTAASSPMADSLVALALSTIPQEAAQSGIASFPALSARFTESVAPQLKKVSLLPEHGGVVAYLTSALASHALFEKEGWADGQDLVSTVARVKFWLANKDLDLAAREVNSLTGWPKALAADWLKQARQHLEVKQALDVAEREATAENLKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6X4</accession>
    <name>A0A2S5B6X4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6X4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="194" mass="19785" checksum="AC72106438E66197" modified="2018-07-18" version="1">MGGYSSSGMGRYASSGDDGYSSRQTGQGASRASYYGGRGGLGGRDESAGYGRAASGLGTGAGQSGMGGAGEGYASSDDEHESGLRPSATVAQTSLPREVAGAHKDARGLAANIEHLKEMLASDKHAAEPRVHEAVKNVADHMKQVEQRLHDLKVRANSEAQSGFSRTTGPQAVAAHSLGSSCARCGYSGASSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B762</accession>
    <name>A0A2S5B762_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gluconate 5-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B762"/>
    <dbReference type="STRING" id="741276.A0A2S5B762"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32026" checksum="266FEBB25EC78581" modified="2018-07-18" version="1">MSCANFAASKLFSVKGLVAVVTGGGTGIGLMATQALAANGAKVYIIGRRKEALDNVVKNYSDVEGKIVPIQGDITKKEDIKRIIAEIKKEHEGIHILVNNAGIAGEVSRVSKEASGQEISDQMWDEQTFEGWDNVFRTNVSSPFFVTAAFLPLLQKYTFGGDAAGKAIYEKYQTGVITISSISGFLKIAQNHFAYNSSKGAAVHLNRLMSTEWAHTGIRFNTIAPGMFPSEMTTSGSDDKQKSSLDDFDPASMSIPAERAGTDEDMGGSILYLSSRAGQYTSGTVLVVDGATLATNPSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B767</accession>
    <name>A0A2S5B767_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THO complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B767"/>
    <dbReference type="STRING" id="741276.A0A2S5B767"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24661" checksum="1D7E3767EAE97E22" modified="2018-07-18" version="1">MGASLQDQHLPAEHLVGLIRSLADQVVQAKLDSPAPDHAAFDPEKVLAQSAPAFAALYGLTRATQLDAKSCRAKTQEARLEMDAAHLRLQNLLFQRNHIEREIRAAEEYSSEYQNLPLHDLDELRQLAADQEPPVGLQVPLPAGDSDESTHELMLARLAFELAERKRFEEERKELGAIKAKLVKENEVKKARLEELEKELTEFVGKGKGIQAKMQDEPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7F7</accession>
    <name>A0A2S5B7F7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7F7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7F7"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="113" mass="12627" checksum="A2F613663FA346E0" modified="2018-07-18" version="1">MVQRVTLRTRSSYSTKSNGKRIVKTPGGKLRYLTVKKAASAPKCGDCHIALPGVPTLRPRQYAQVSKRVKTVQRAYGGSRCSNCVRERIVRAFLVEEAKIVKRVIAQQQQGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7V0</accession>
    <name>A0A2S5B7V0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7V0"/>
    <dbReference type="OrthoDB" id="2529000at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015522382" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="24288" checksum="51F1432E5685397E" modified="2018-07-18" version="1">MRSFAVSAFVVLSAAGLVAARAGPDVHIARSVRSLARRADASAPGSSQYLSEIFAMETAQCNSTCAVSLGDFDSCSKLSDQATIAACACSALTLGDLRSCASCISTTTKSTSNETSVVSSFVNLCLQEGLATVTGTVEVGVSTKPISRSSTSAASSASSASRSASSVNASSTVTSAPLATYNPSASYTATATVPSLVASGSIASSARAAAASASPSAQKTSGARSDGSVRMAVVAFAAVFGAAALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B870</accession>
    <name>A0A2S5B870_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease</fullName>
            <ecNumber evidence="10">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_3945</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B870"/>
    <dbReference type="STRING" id="741276.A0A2S5B870"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000008">
        <property type="entry name" value="Probable NUC1-dna/rna non-specific nuclease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015521534" description="Endonuclease" evidence="12">
        <location>
            <begin position="20"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="14">
        <location>
            <begin position="95"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="13">
        <location>
            <begin position="96"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY72959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="373" mass="40097" checksum="DCA80B0185222E24" modified="2018-07-18" version="1">MSSSLLHLAIAGTSGLALGAVGAVSLTRSSSKPSATLDGASPAPGPPLGTAPPPLASRPETPYPGQIFSGNLAQGEVRSRVIQGGSIGPVSDLLIRTAYTAAYDRRNRIPAWTAEHLTGSSLKSGGGDRATAVFREDLDVPEIFQAKLLDYFRSGYDRGHMVPAADAKQSQVAMAETFLLSNIAPQVGEGFNRHYWAYLEAFCRDLTKSFEDVYVFTVPLFLPKRDGRDGKWKVTYEMIAPQGGAPNVAVPTHFAKVLIASRAPRHPSLALISKQKGVFADGKEWVQSAFVLPNEAIPDETKLETFVVPVEAVERSAGLSLLPEALKAANVKHLCQATKCEVVVRRFDDAQKKFGGKGQQNSSLPAPQRRQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8A7</accession>
    <name>A0A2S5B8A7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY73012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8A7"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="245" mass="27416" checksum="4B1D1542D69511D2" modified="2018-07-18" version="1">MNSAAADLEGAIEGLYGQGTLTWGAYKKLLALLHSCQVHHVAGEQDVHRWFQEILQGYGTATSEQKGALTRDVSAVLSGLSSGLTWPPKLPLKRSKTGAVEVWEALVLFCDTHNYSREPGVRAWAAAVCANAYLFEAANRWWRKSFTEGLNALYRTFRMLTPGRQCSTALSGHLTGLRDCERASLVQPRVMKPKRLLKQRPLRSPQQANLRGVTHTTPFAKLPLIRKRRPVRQSSVYIPVNRRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8E0</accession>
    <name>A0A2S5B8E0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8E0"/>
    <dbReference type="STRING" id="741276.A0A2S5B8E0"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="634"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="719" mass="75928" checksum="4650420A064CCD78" modified="2018-07-18" version="1">MAFKRPFHAQSRTPVRSSDVRRFRDSLGRQFPSLDSDALKLLTKDLLVAKAHTHLDEPCTVYYAPNGDPRFFKLQDDDDWVPTCYAFDLVAAHAHGQTDWIPTLGTAPAVVQNLISGSALFAAGVSPRDLANLVAASSSSSTSPSSARKGSLVGITVASSPNPRRIVAVGRLAADPGEIQHSQRDDKGGKAVLTLHARGDFLWQAGSKLEPAAAELDLDPRQNRLAEDEGAHEDDDAQVAQMTDRLAAATDLSRSNSTASSSTAASLSAPPPASSSRSAKKGKGKKADTPTGPIDKADATTSSTDALSSTAPASTTDSLTPAEADSVLLNALLLALSTSAALQKPATFPLPASSLYSTYILPFRPASPPSHATVDLKKSSFKKLDRFVKQVVKKGWIAAKELKKGTGDWIVTSVESRHPDVERAPRYRTVAELAGASAGSDNADATLTTTTATRGSEPNAAALGGASTAGSSSGSGNGGGVVEVRELWKLSGDSVKELFRSVPHDRPPHDLYTTSELSALLRKFTDSHSLSHPSQRSLLLLHPSASPRPPSLEQLNAIELLARCVCKKGEKPEEFGKERGAPGLVSRDEALKRIKKDGCTGYWGMRNGGGGGTADEVVKKGSPPTIKVAIKNVGKRQVTLISGHEPWDLFTSEELAEKLKHASASSTSIQPLAGSAKKGQTPKVEIMCQGTHDALVSKLLVGFGVSKAYIEVDLSKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8M0</accession>
    <name>A0A2S5B8M0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8M0"/>
    <dbReference type="STRING" id="741276.A0A2S5B8M0"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34550" checksum="28D95D008067439C" modified="2018-07-18" version="1">MSSSTNSWAGTASLATPERLVVGGLPVAVYGLPALTVPASASSGLAVLFLLHGRGESSQSDYLTTLATKLVESARDKRAQVSPLGADSGTKRAKDLLVVTFDQRNHGHRLVNAERNMGWMEGGRKRAAARKEKGIKPHELDNEGHAYDMMAMQTGTSRDVSFLIDFLPPSLFRDDERTVTDWYCSGISLGGHATWLALAHGPLPLAAPIFPASLLSVFDRFDPASPSLSLDRWKGKKILVLSGEEDKLVNFVHGKSGVFVETLKGVEGCHVEAYVQPKAGHECTPEMMERTCEFVWRCGLNASSGPVTQQQQQGPHGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9H5</accession>
    <name>A0A2S5B9H5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9H5"/>
    <dbReference type="STRING" id="741276.A0A2S5B9H5"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="491" mass="53389" checksum="E32DB27A419F7A3D" modified="2018-07-18" version="1">MATVPMSETDLYFPSLSLGRCTPDVPRRKILVQDDMDTWLRSEAYTNIERFIVRLRQASERPVNEAHKSSEAVERVNNLLRDAAGWLDGSASPSELGKAFKAWLRKVEQATLSVHADVLSRDQQKHAGPELIFHLLASFGSPARLDYGTGHELSFLAYLLILRLIGAVQPEDEPAIAKETFALYLDLMKRVQKTFRLEAAGKMGIWGLDEHQHLVYHWGASQSRIHPSKRPALLVAPPGSAGISYLFLSSLLHLNGDPVPTSKARDQPAEAARAGSSAPAQSEADFQGLLRLYKHEVLDRLPVVQHFRFGSVLRWSEPGSSTPLPSTSDTLSDEELETLDATLDKRVMAEGTVAPWSLPSLSGDQKPDEILEKLPSPTLSRTASMTSASSLPATRTGSPSPKSRASPLPYSASSPNGNGSTMPPLGTSPMRSPMQRRMSRLSICEMAGDEAGTEGTATAPATTSAEAIREMVKGGNKELVAEGDESPFDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9N5</accession>
    <name>A0A2S5B9N5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9N5"/>
    <dbReference type="OrthoDB" id="2533168at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20251">
        <property type="entry name" value="Complex1_LYR_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="234"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="479" mass="54475" checksum="03C3C68EC6E53148" modified="2018-07-18" version="1">MTTAGPDAARSLYRSLLRTARRMPDDHRTAFVVHRVRSEFDRAERQTNPSVIERKLVDGQVYRDQLELQARHLSELASQPLLIPVDLRSSSSPPPVASTSKSTLEALSKKQGIPRAAHRSDSTTEVTSASTRRGPSRPPRRSSPLLQPSDPTPESRTPPRVAGPRPPLDRRKLIRAFQARTAQSRADSHKSNRFMQGPEPSWMARKKMTPSADTEPTIALQGPHTRRRRKVIRPDRLQELPLELLLLITSHLDLASLLSLSLTSKPLRALVLGQQCEPFWLAAIEEAELPELEAPLRAVEYASLVCGKRCRVCGKNNARKVEYHLRTRLCAICWDDQLVYEGPDEPDPAFEDFFPGTKRYTPRSRTGKGWKRHRTFFFLWLLESTSTYLASLLAPQIVAYDLALESDPLAELDDFLAFSALPASIRRELDERAEWVKKCWRDGEKLGEWEAEMKRRRRIELKDARIERRLAAERVAGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9T5</accession>
    <name>A0A2S5B9T5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="741276.A0A2S5B9T5"/>
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    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="R3H-like domain"/>
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    </dbReference>
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        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="291"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
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        <location>
            <begin position="654"/>
            <end position="679"/>
        </location>
    </feature>
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        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
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        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1020" mass="104977" checksum="00B51DCF9FD210EB" modified="2018-07-18" version="1">METNSSVDSTQAMATSMTQAQPEQATLADKLKSLHLANEPDRTQPDPLPVASTSSSPPRSGPDPFDSRPDRTEPNDAPPKRKVVLLKRPATPTRSAEGSPSRLTAEAAEQQPRPDTIGTLDDRRGSSEAAVQNMEPEHTADEDDGAEADPAALDSVVRGALSHPRDRFLLLRAEVELERFVLNPAISRLPLAPPHFQPGLNSYQRLLIHRLADMFGITREVEPAPPTLWNAGMINPATGQPQGVVVLVKGEAAAIPTRKLATYVPAPEPAPSTVSSPVPHLPIARNSSALSSPAASPDEASPAAAVGASAPPPPPPVFKILPRASRGTSSASSSADVDDDGTSSLGAGSRSRLRRDLTLEEREAAYKEARERIFSQPDPVERSTPAPSTASAASSIAGEDAVSVQSLGYGITRPSSAGSTFSRSSAALSVSGQRPPPSIASDSNPAIRPGYYGGFYQQQQPPPQQQPAMSGMPYPMPNLRPAAPPVFDPATGGWTYAPSTDYAAASPYSMPYGAVQPPPPPPMPYQSPPPPVSQFDSGSVATPSAWHRSLPSPALSGSSGSSYPPQMYHHQQQTPQQQHGPAAAQSPSSVTSGAGGSDTGYLMRFPEGAIVTAAGAVVGPPQPYAAVAVGANLRSPSSISLGASSTASRVATRGGTSTGPNSLRRLSQSTTQSLGSVHSYSAPPSDDAASRRSPSATSGAADDSPEASLLGENFSEVGSSAGGEGSAPPSLVSGGSDGKRRGRQTTIVSRGGRAERERSLRPDGEAGDDDDKVRERSTLHPSLPAKPSWAAAAGGGAAVATAQGESSPTVPRAGQAASPQTSRTSTTPSRHDAPVSLRDLPGLATGLRGPPSTASSSPGYPPLSTAAISAPPPPPPPGPGPWSRPTPTYVAQSPGSNSHGGHPTGYPHYAAAVPPPVPYTAQHPSSYSAWLSHASKGPPPSHVGYAPAPRHPQSAQMYPHSGLEGGAVPPTGSKPADLMTMPDMRRPPPRSTQLFDPNKPGSAGNMRRVASGAGSARGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAQ7</accession>
    <name>A0A2S5BAQ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAQ7"/>
    <dbReference type="STRING" id="741276.A0A2S5BAQ7"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="196" mass="22432" checksum="79EEC18D5E58F932" modified="2018-07-18" version="1">MDSTEPPAGANAVEAAKRYNQVFQSYLDRTTPFPLYRWGSTVAVFLLFTLRIVWVQAYYIVAYALGIYLLNLFLAFITPKFDPALEADTDAEEGAPTLPTSKGDLAADGEFRPFIRRLPEFKFWSVLALPPYSATKACSFAFIAAFIPVFDVPVFWPILVMYFCILTFITMRRQIAHMRKYKYLPFDMGRKSTYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAX6</accession>
    <name>A0A2S5BAX6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAX6"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="270"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="469" mass="49363" checksum="BC6A43D63BA20AFA" modified="2018-07-18" version="1">MGTAAPDASPMAIPTGPSPSGDAPSIRSSSPTASSYPPAPSTKAPSERELAFIPPPDRGKAAYLFLAGAFTIETVIWGLPASYGLFLDYYQREGVADILGPPVALLLNPRPRWRLTVIRIGCCLCPISLLLSSFAKTGLLYSIGGSMAYYPTFDYLQEWFHERRGFANGVCFAGDAGTAAGGLILPFVEEALLSRFGAERTLQSLAVAFAILFAAALPLIRPRLPLPPKSSLPIKKAARESEREGETERRRSAANDTEPLTARVVVKNIRLWTFLAANILQGFGYFVTFLYLPTYATSLGLSGAQSSGVLACVNGACVVSRVTMGVLSDKKSPHQLGFAAMASSAVAISVLWGVTSTTFAPLVVFAIVMGLCSGGWTSLYSAIIKGFIADEPSLRSQLFSIISLTRGLGALLCAPIASALISHPLTGASKHTAYGSGDGKYGGIVLFAGLAMALGAALEGLEWLLPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB06</accession>
    <name>A0A2S5BB06_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000031">
        <property type="protein sequence ID" value="POY73944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB06"/>
    <dbReference type="STRING" id="741276.A0A2S5BB06"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="81"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="192" mass="21838" checksum="C1A08680A1832A21" modified="2018-07-18" version="1">MTSLLAHLPDLSAPFRAAVVILNLRNPINAVLLAVITILILRILLPPPPYAPHPYGLATKPSEAYNWRPERHPHSQLWRTWTPRQLEKYDGTEPNHEGGRILFAIRRKVYDVTAGKSFYGPGGPYEAFAGRDASRGLAKQSFEKDMLTPLDQPIDDLADLTKSEWDNLRDWEGHFNTKYTQCGDYIEAEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB31</accession>
    <name>A0A2S5BB31_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000031">
        <property type="protein sequence ID" value="POY73941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB31"/>
    <dbReference type="STRING" id="741276.A0A2S5BB31"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="189" mass="21382" checksum="898D333B04081B48" modified="2018-07-18" version="1">MSNKQVPAVYRSIMTDVIDQIRPEFDQLGVEEAVLQELLRLWELRLAQSRAADFSQDERMAPVAKQFPMLSHEEAAEQTLVLVKQEEDAKAEAKKAVKSAANAGKDRPKGEDGEDEDDEDAINSDLDDEDEEAEDEEAADGVETRDFVIALYEKVQRTKNKWKVTLKDGLISVNGREYLFAKCAGEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB71</accession>
    <name>A0A2S5BB71_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB71"/>
    <dbReference type="OrthoDB" id="10609402at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="366" mass="37443" checksum="24137D6CCEF2CB7F" modified="2018-07-18" version="1">MPASEAAALETDSEASGESVDVQIADLRLADRPDRAPSVARAAAAPSPARGPSTRRSSSLTTYTGVLPGQAPARSRSARAASPELRYSIPLAGRRTSAPPVTPGLSTLVAAAAPVAKLERRLSTTAGRPPSPAPPGFKTSLRPLGAARAGLSPISPPAASAASKLPASIGSTSSRARSRSPAPRGLVRAASPSPTTSPPVVRARAAAPTSSSVRSASPESAHAASPSPAPAVAQAPVIIRGFDLPSSGSAPRQGLSALPPSPSMSARTLGLGIRSSRIHHGPAGPIVRPPSALLDRTADQRLEVAASRDFERIDDYYAARYAAAEAAAQAGEPGRYATSGTTSREQRMQKRAAEERLRRGYDRVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBB6</accession>
    <name>A0A2S5BBB6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_2865</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBB6"/>
    <dbReference type="STRING" id="741276.A0A2S5BBB6"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="61"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY74053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="465" mass="50842" checksum="9735B82CF1643288" modified="2018-07-18" version="1">MATGVPQSQRESRVASHSHIKGLGLDDDGFAHADRAGFVGQRAAREACGLVLELIKSRRFSGRALLLAGAPGTGKTALALAIAQELGQKVPFCPMVGSEVFSSEVKKTEVLMENFRRAIGLRVKETKEVYEGEVTELTPAETENPLSGYGKTISHVVVALKTAKGTKQLRLDPSIYESIQKERVTVGDVIYIEANTGAVKRVGRSDAYATEYDLEAEEYVPLPKGDVHKKKEIVQDVTLHDLDMANARPQGGQDIMSVMGQLVKGRRTEVTDKLRAEINKVVNSYIDQGIAELIPGVLFIDEVHMLDIEAFTYLNRALESPISPHVIFATNRGLCTIRGTENEPGSNGGEGIVSPHGVPIDLLDRCMIVRTMPYSRDEIKTVLQTRLKVEGLAIQPDALEKLSDDGVRTSLRYALQLLTPASILSKLQGRTEIALEDVAETDGLFLDAKSSARMLHERGEGQYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBR5</accession>
    <name>A0A2S5BBR5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBR5"/>
    <dbReference type="STRING" id="741276.A0A2S5BBR5"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="70395" checksum="B1F2E7F1300033FF" modified="2018-07-18" version="1">MAQNSWAAQLDRLVTNPAYHDVLAILKGARNGLVYGVRVRAPHALIMTLIFHSHKSWQQRLLYVYRATKQHSLNLARFVTIYKTMLLVQKSLAGGKQRQFDTFFAGLVGGWAVFGERNAVNEQIVLYVVSRIVTSLLPRATPPMSAGSGASRVSATAPDGFPHPPGYPYPKSRAPHPKVFELYSAVAWGIVMYLFREKRDRLHGGMVSSMQYLYLDSEVWTGLKTLLWPNSLAAMYASRKKVAAGNDDSAAGGSGNALAEVTLPKPDLRDLAVLHPETVSKAAIGTPRAYPDDVLQAFKAYTLPRSLQKLHALTPRPATVVREATVAAARTLDDARKGSSRDSRYMLSGKEGSGKTALLVQAASYAHSNGWVVLYIPSATSSVDSSSAFTYSTDRALFEQPNLAADFLRRFSAANKAAFKAIKTSKARKVGEKQVAAGKSLEELAKAGAGDEKLTTSVFEAVMEELEQQKEQVVLPPRPVLLAIDHVQSLFSLTGYTDPSYQRLHPYHLVIPRMLLDYAAGQRSFAQGAVMLSPSSRYLSSSKPLADFLATGGQNSRTDPLPSVYDRADVPEYSTYATVLSSGIKTFPVPERLSRKEAIGVVDLVKGWRGTREAVDDASFLERLVATDGNPRLFMRALTKNVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBS4</accession>
    <name>A0A2S5BBS4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBS4"/>
    <dbReference type="STRING" id="741276.A0A2S5BBS4"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17302" checksum="58EEE2A278276D47" modified="2018-07-18" version="1">MAVNMNADEAAAERRKARTFKKFSYRGVELSQLLDLDSAAFTELVHARARRRFQRGLKRKPLALMKKLRKAKTECEANEKPAVVKTHLRDMIIVPEMVGSVVGIYNGKVFNAVEIKPEMIGFYLGEFSISYKPVRHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBS5</accession>
    <name>A0A2S5BBS5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBS5"/>
    <dbReference type="STRING" id="741276.A0A2S5BBS5"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="333"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="602" mass="67920" checksum="F7AFF3E58EC511CE" modified="2018-07-18" version="1">MTVPNIPVTPGANQIRTVERRSNMVFEKNVDIPLADGGLCRCNVYRPLEDGRYPVIMTMGPYGKDVPYAQFHVKSFAEIPDEQKGDLSAWETPHPDYWVSQGYVVVRVDERGVGSSPGFLDTMSASTSSDFAECVEWAADQEWSTGKIGLLGISYYGGTQWRVAARKPKGLTCIIPWEGMTDYYRDRVRQGGIFSNQFVQFWFNNQVGPMQYGNAEKTIRRWGPKAPTGEPVGPDCIEGTIPREQLLELRRDQTIDNREHRYLDEPYHSSRVYNLGDIEVPVLSVANLGGNTLHLRGNVMGYLEAGTKNKWLWFISGRHDLPFYLPHYVELQKSFLDAWLKDEDSRGWTKGPNVDIPAVNVLVRKGNPGFNSNEAEATFSNRPEQSWPIERTSYEKFHLHPDLSMHRDEPAKESNTLKLAALGKTDPLQFKVKVDKDTEIAGHPLANLVVGVEERADGTAPTDLDLFVTLRHFDAEGKEIFYTGTAGDPVPLVKGWLRASMRKVDESSPRHRHYLPHRNYLSTDVSMLQPNTPYELQVEIWPTCVVVEAGSSIVFEVATGDTQGCGIFLHHEPTDRSEEVFDGTNVLYFGAEHQNYLQLPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBT2</accession>
    <name>A0A2S5BBT2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBT2"/>
    <dbReference type="OrthoDB" id="2500774at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="674" mass="71272" checksum="579EE548FAAF59AE" modified="2018-07-18" version="1">MASSAYLAETLSSLQQSASVLKSLSFSSRAVLPACVLASDDWFETHLIRDAAPAELALYEPNPASYPVVQLDVDDPALLIPHNDDYEANRLAVAKRKAPKRAQIAQEALRAEGGGGDDSGDDGQLHNDPQRCLLTAQKLLNYYAMPRAQEHVQALHSQLLGLMDSIHSTEDALRRPPSRTAPQPQHDQSYYRQFELEDEIKREKLELLALEQIKADKQAEIDALAKEAAAATAKPRPRTSVPSTGSDSRATPATAAPRPVRPRISRPSSGSSPRTSRPARPSSTSDSAGPPVRRPSAPPLPGPVTATATATASGAMPPASPARRPIGRPSVPSVQSAMKRRVEQARAKVQASQQATPNRSQAFAGGGRRASGTETRERRGGEEEEERGEEEQRDGAATTPSGPRRDGETGSAAAAAELPPPVPMVSNTAAAGPPERKGQPRPVQLPAGVTVAELEGANKTIWSTLGESTGLKQWMRRWVHETGASAGARGDQTAWSETSDVLAFALAESVKSSTQTPGSPSNQSTTSFATSTAAAGADENASPAPWSPAQVVEAQLCYLLLSTFSGRAIAQDDDLPALHVILRETAIPLPSSSVTSAGSSSSATTPVRPGLSSRKTPHVAMAALKVHLGAFAKRRGWTEEMGTTAIYALVSRQTVKIDRRGREGAAVGFKAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBW7</accession>
    <name>A0A2S5BBW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBW7"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="253" mass="28052" checksum="AC143829D94BE73A" modified="2018-07-18" version="1">MQVWRDHKLLCGPDGFLKLQSAPITSEEHALLVRFATVQHSALLSYLEDLPGAQQRAPKVALLTLSGFVEVIAKLAAGSFTRTSLSDLNAALHRWNSFEYSSFTVLRAGMCSGVRMASENDAAFDLDGKIIAAYYNINWCKAVRGPGLPPPIRAMHICAFLQGIVIWHSALRHFHEHIDDRREELTAQQMAATLERTVNSILPHIYMASQFHADVLTRNLVSWTAGIPAVAHLRAVMGFDDSKKRITTFTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBZ2</accession>
    <name>A0A2S5BBZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBZ2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="204" mass="23069" checksum="DA96DAF69AF664A6" modified="2018-07-18" version="1">MTGAETGRTLTRILLAPPPWQPRIAPLEEADRAHGYLLEENLKPTREKLNRDFKKVDACLSDTQRSRDFLQGLVGKGGPIHSPPKSTDHKAMRVRKFISDWDLRDGPKVAADRPLPPVVETAAACLSGMTKRQTARTNDKWFSEFCHRQFVHLELGLVMERLTTEGDLRQWMLMLDQCHAAGIRVAKAEAAPCLRASIVKCWCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC18</accession>
    <name>A0A2S5BC18_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC18"/>
    <dbReference type="STRING" id="741276.A0A2S5BC18"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="18972" checksum="553D4B1A3FFF76E5" modified="2018-07-18" version="1">MPLYELVCVAKHHSSLSPLQTLIRTSSALISDNGGVVRHLDHWGTRNLPQRMKVGKRRGGGGGAGEDAVSSTGDYFTLRFDCNPPTLQTLTSRLRLDPSVLRFTTLKIGSTLDQIANAPRARGENRTVKFGRDAPPVASLAAAQGGDAASGLDAARETMMSRTTQAQTTRRAWDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCA0</accession>
    <name>A0A2S5BCA0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2577</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCA0"/>
    <dbReference type="STRING" id="741276.A0A2S5BCA0"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="279"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="620" mass="69175" checksum="EEDEDDF10E2674A4" modified="2018-07-18" version="1">MAEPQPPPAGPTTPSAAPAAASAPPPAPVVPGPSTRSLPPKPPKKPTNPFVYLGIPQFVLDWRPSRPGPKMSVFLAVTTTLTGMYVYDRQETKRIQQEYIDRVKWLSEQPLETSQRARKVTVLGARVPDDGELERGAKWFKRYMRPILVASGTDYALKVGTNPGGLARTLAHEIRGKRITEAAQQADNAAATVLFGNTPEANVNAVLAAHDLEQEKLQENGAIVLLGRGALKEYLWALKKGWGEAIDLRQEGKLEGLGLGANERRKDGRWEREEELMLRELDEEDESRPDGGPFDERAAPTGLDSVGGDDSSDAPLPSQPVSFLAPSPYQSLAMPPPPPSHRAAPSEPEPPLVLPPSDIPQQPPLLLVPFSYPFGIRTWAGKLAHFWNHRADAKVGGEYALALVLSQARPFDAPRNRDSATGQVAGLLDDEFVATIRRGEEHLSTMVNGVLTGSKDLDFLAETDERPEHFKKAYRTLPKGHEYFRRTYYNDELPPKLKTARELARGEREPTKAETNYPPKIESELRKERLDKELRWRRELEGWAIQRAGSGISWQDGWEDKLSVIEVPPSADRLAELERGKREWYDLQQRKDEERERYFAEQDRLRGHDLSADSGEAQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCC5</accession>
    <name>A0A2S5BCC5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCC5"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="72"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="547" mass="59241" checksum="711A677BF4EF7D4E" modified="2018-07-18" version="1">MTHELDELGSSDKSLRDAMIDAEKDGVVEVHNQESNEALAQAEGIDAHFMVKAQVINEALEECGMGRFQWELFVSAGFGYFSDNIWLQSIAIIMPYVAVEDHFPNYPGIRMATFALYMGLIPGALAWGMTADVIGRRLAWNSTLFISAVFGLAAGASPNFYVLCVMLALNGIGTAGNMVLDGAVFLEFIPNTHKYLLTLLSVWWAIGQVVASLICWAFIAKYSCDTERVGIDGYRCDRNTNPGWRYSMYTLGAMMLFLWGLRFFVLPMQESPKFLVSIGQDEEAVRVIHTVAQRNGRTSSLTVEKLRIAAEPYYSKFGDRAPSTTKFSNLELAKRSFSHFNLEHIKGLYATRRLALSSSLIIFIYTALGLAYPLFNGFLGGYLQSKGAERGDTSVNATYASYTYQAACGIPGSVLAAILVEWGRGGRKFAAAFFTVGAGAFLFGLTAVRSAAAVNALTCMASLFENAFYGVIYAIAPETFPTPHRGTGDALAGSASRLAGSLAPIIAVYSAAAKTPNGPVFAAASIFVVTGLSMLALPIETRGRQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCG4</accession>
    <name>A0A2S5BCG4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCG4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="219" mass="24234" checksum="94B0A0AB343DD2B3" modified="2018-07-18" version="1">MQPNGRMYQAAGVRSKRSGAANIPTSCPQDTAGAGVFTSPGAAPMTMTWTLGWLHSWRARATIRGLLAAGAAEALEEVRKLKNMTITEIAAQQFSETKTVLSYAMENSNVMFDYGNEMIAQNVLRVLQMQRARREGCLDKLNRAAVLLVGKGAEKQLSECESIIKKIAQVSQKRRQARDDLKRDVESINERALGEVYSLQERFQANANKLVQRLEKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCM3</accession>
    <name>A0A2S5BCM3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="10">2.7.11.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCM3"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="70"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1110"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="711"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="842"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="986"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="730"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="857"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="914"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1403" mass="147358" checksum="E5905177E08CD1FA" modified="2018-07-18" version="1">MATALGPDASPVYATHQQSNSVNGYGIDLAVRPATALGSSHFASPPNSALSPTTHGGNVDGIDYAGLPRWDDAQVAAWLTAALPTLANNYADTFASNDIRGSVLLEVDQSALKEMGVKSVGDRVKICVAVRTLRTKYNSALAAATSSSSPTLSAGASLSRRPSALGRIGPSPLLNRVPYSPPSVPSSASSPTSLVSSPPQPSISSLRPGSTSLSYSARNISVGNRIPPPLHLAQSNAVSSGGISTQLSPPSATTSPKSATFAMPTPSFGEATSPMRAMHAVYPAQPAPTGRIPPTPTKTTTALPSPSRPHHFDTSPILAQAPQQYQNQGLTTSVSASSLASRPPQTYGSGHRKANSSSVPAPAGGAAPNNSSNRPPFAGQAVSYAGHPYAASASSSAASTLVPSTLNSGSSSSTLTSTSGLLPSAIPALPPRFASAPALPVSSSASAPSATQLSNLDVMRKAVKFTSADGITTRVLAVADARDGREVLARVMKKFGGREGEDLDGWGVWTTEVTGAARLLTEHELFQICQNASAPERTRGLIVRRHHTQQAHSTSPPSSHTPTFSSTPTSPSQTLASSFSPTQFIKDRAQKLQWVFGDSHTSSSDGTSMRSASGSSHQHLGADLPRIGAIEPASPTMSADEEDDGAVLVIAPHAAAERDAAERARTTKLNRASTVSIMSGLEAPDWARNYYSGGENALDTASGTAASSVSTSAAQSADTPLYARGHTYVPPKRTSSRRTAPSAAAQVAAAASQPAQAASPPKLPPRGPPAPSIASEERQGLLPESTRKLRNFFGQRPPSELITTHLTEFFPLGLRGSGMDKVDRKLLSKQVRASIRRSMSAATGGALLPPGVDATGRRSSTASIASRTSRHSSLRPRTSGASGLEPFPRIASPVSHGETSWEQQRDARPQVAESASMSRFSGSSNGSVSDLPLASTGSSLRGTRSPRSSSGSALDPPDETAEDDGVADAAQTHLVVPARVAASPESVAMAMRHSSSSSAGETTTSAGENDLAETRSLASSLAPSYLDPHGLSSNRLSRRMSRMSGSSRLSVGAQSLWERRSRDSDVASIITVDDVTAELETRRQSGVSWRNSDEDDAEEDLSVYVKGMKWIKGALIGAGSFGSVFLGMNPMTGSLMAVKQVELPTGTSHNEERKKGMLDALEREIELLKVLQHDNIVQYLDSSTDDKHLNIFLEYVPGGSVAALLQNYGAFEEALVSKFVRQILTGLEYLHGREIIHRDIKGANILVDNKGNIKISDFGISKKVEDNLLTGAKVHRPSLQGSVYWMAPEVVKQTAYTSKADIWSLGCLVVEMLTGAHPWANLTQMQAIFRIGSSSRPTVPDDISTEAHDFLDQTFEIDHEDRPAATELLLHPFIRESDGWTAAAQQTPTRATFSEDATVAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCQ3</accession>
    <name>A0A2S5BCQ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein YTP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCQ3"/>
    <dbReference type="STRING" id="741276.A0A2S5BCQ3"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015695572" description="Protein YTP1-like C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="161"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="400"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="75767" checksum="8027DEAC1D9E6A88" modified="2018-07-18" version="1">MCSRKTFATLLSFSISALSILSAGAAPSPSFAPAVRTRSTPFTPELKLITRHGHHHDPPDPNGVAEETDKLAEVGWHVTPPSETFVSEEIDDDDAGSKSAHMLQQHESHHLEQQEEAKGVVGHSHDGGHDHHYSHAPPLLVLNESLILLTHAPDPPSYWDFDQGENGKGWLLYVHIALMTLGFFGLLPLAIFLKAGRSPLHVVAQAGFLVSSLSGLVFGQARCRTSVRTLLPAADHLDFVQLYNGVTPNMYEGSSHGAWGWFTMLLTFALNAVDVARFFLRFTRWGKTGGLPSSSGLQQAVKNAGMDETTPFRLGGDDDDEEDEVDRMVASPSTSSLEQPISPSYSRNNSLALSDAETVVQRDESSWSGEQASPAPARRGPLKWAALALDAAERSLILLAYVEVCSGVAVWTGTCRGNYLNGCLAHIIKGSIFLWYGLLTFARYCGAFSSLGWAWNRHPSKTGSIWTAEFVESLVIFVYGSTNTWMERMGKSGSPYSVKDVQHISIAIMFWAAGAIGMLLESRTIRAWLSAPAAQTSGRPLGSISPPASAGFSFNPFPALCIGVTGVAMAAHHQTYQFQVDIHALWGNLLGGFAAFRFLTYFFLFLRPPSSILPSRPPTEALASLALTCGGVVFISSVEQVTFAAMRHGADDVMAFLNIAVALVCAWFFWTACLFALKGWALARSSRSSSPTSKFVDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCW0</accession>
    <name>A0A2S5BCW0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCW0"/>
    <dbReference type="STRING" id="741276.A0A2S5BCW0"/>
    <dbReference type="OrthoDB" id="4087970at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="210" mass="23686" checksum="430C22209F64A416" modified="2018-07-18" version="1">MKDSGAYLSAYTKRRPKEWPSHSLDHLPLLLSIYTVCARPSKLPRSGNATLQPPAHGKQRSKSKRHYRAVKRSDSASAYKIAEDIRLQRLSAQLKQSALKPRALTDKEEWERKQAGFETDDDEEEGEGGEQEQQTGMETEEPVASTSTAAAADGETKPEDDKKISTSGPRMSRREAYRSSKGFTVKQTPTTHFRSKGEKKRMGCKPHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCW5</accession>
    <name>A0A2S5BCW5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCW5"/>
    <dbReference type="STRING" id="741276.A0A2S5BCW5"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="47774" checksum="E6641E9F716815FE" modified="2018-07-18" version="1">MSPAVQYGGDEVGAVVLDVGSHAVRAGYAGEDAPKAVFPTAYATVPTSTDSASHFHGNSAHLYRPNATISSFVQDGIVSDWDAASRAIHHAFAERMRIPTLEEYPLLATEASWNPKENKERMCELAFEQWQAPAYYAVDKAVMSAFAAGKGSALIIDVGAELTSITPVYDGFVLRKAIQKQPLGGTILSEVLLGSLKEQSVPVTPHYLVKTKEAVEPNQPARAQLRDERIPNPSDPNAPTTASYHHFEEVRLMHELKESVCEVITPTWDENVVQSKPTRSFEFPDGYNTYLGVTRLTTPEILFNPQEHLPQQFTTRPQPPSASTIPSHPPSALQPLGGLIRSTLMQVDPDLQATLLANVVVTGGTTLIPGFVDRLQNELTTIAPGMKIKIHAAASAAERVNSSWLGGSILASLGTFHQLWIGKDEYQEVGKSIVHRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCZ3</accession>
    <name>A0A2S5BCZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCZ3"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1349" mass="140720" checksum="065AD7D2A79AE77F" modified="2018-07-18" version="1">MKRSYNASAAPPNPYGVAAATGYSQPGVAPPPLPAGPPPPAPPQGQAQQYQNYGYAAGYGGPAPQQPTAQQGGPAQPVMAAHPQYPGYGYGAVESKGKQGAAPAASAGPAATGSYPQQQQQQQQQAQDPNAAAATAAQYAAYYAAYAQQFAAAGGQQNAMSPYQTAAPGNNAAPPPPPMQGQYGQSMTPGYPGPSGSGSPGAPPYKRTRYDSNPYGGQPAYSNNAAPPTLPMGQPPLPPGPPPAAPYGAGSAPMPPSVLPPVGGRGPPPVRNAGPPPLSSRDGGGRGYNDGPRGGGGGPGLPPRPDPYARESRRDDGMYDSRGGPRGPIRDGPRGGGPIGGPRDRDRDRNRDRDRYDDYAPPPLPRRGGPPGGGYSDRGGRSPILPPRGASMGPRGSAPYRHDDYPSPRRGDRGGIPAGPSGRGGPSGSSSGKFGPAGGPPGLPSGPRGLPNAPKGPKGSTVPNAPSGPSRGGVNSQASRKDRKWGAAGGPSTPAFKAASRRDRERDRDRDESNSTSSSKRTLTDFRIEGLGIPELEWEWRASRIEDEMKRVAEELDKQVEEKHAERDHGIEPKAETEPVTDDPAAAVEDNTPAADETALETTDATADMSFEMTDAPNAETDASDTPVAAAGKHGREEDDDEEASSSAVEDNGAANQSAGGAVPATQKRSDHASKPKKVRIDDVDHESNLLAAGVTDDAAIALEAAEDKIAAAKDTPAGEEAVKAEQADGIEVSATDPDVSTVATEQEDDVDGAPIETAEDATDKSSSPTKPSAAAAPPPPRENSRLRIYFTTPVSSSSSYVVPTSVAQDKEPRQSAAPEPAEAVKEEQPEDVTTAAVNDNPPEPEPTPGEVKAEEALADVPALEQVDDKLQEVVADSEAQDESAVDPVSETTNGAESVEAVVVASEGAIGVDAVRQEDSAADPAPDSGAAPRPEAGADNKEDGLVDGPSVEENDDDKTAEGGDKTVADANAPATPRQASVAPSVAPSVAETISAPLPPEPAADRISIAYARNTRRMVLDAEVIEAVKIFRGEGRIELVVKCQPAVYGEPDHLLDDDFRVCKGVLLESLDVEADDYIVVDRNMLARAWASQADQPNETEDHDDLLPPLHRLLTSLEVQDPTDISFAHDSFTVAAHLDRVNPLTEARWVKNGEIDQYILSLGIQNGADPKDPSKLSEWRNKIRIVDPDPPPTIQDTLDAWTASSNVGSKPEREKFVSTHMANIDNVVEILLRLTRGDRTTAPPHTYTSAGQQPAAVGALAVTMNAPFADQQTQVSLAVLGMFRLSVETARKAGIDAAEVERQVSDIVRMLPNHLTFKAIDGMFRELVKGQKGGSAIPSAPRSSKKGRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDC1</accession>
    <name>A0A2S5BDC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDC1"/>
    <dbReference type="STRING" id="741276.A0A2S5BDC1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="394"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="487"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="491"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="656" mass="71867" checksum="0C18F1322AC11801" modified="2018-07-18" version="1">MIPSQQTRRSTRRSLGTGQGVENDVANRVPAAAGRVGNALASGSAAIKPAPSKVVAGTSAQTRRPLGVPKPIVMTDKPAASNAAAGVRGKRSAFADVTNGAKAKAGPSTLGVKPALRTAISSTSANAVASSSNIPTRPKYRTRSSTGGAIKEEDEGLGFADGVKVEQRSDAMAIDDEATTSRATGRQVKSLRKGAAGPSKVVASTSAAPARRPLAAKRDSVNGAVGLGAVGAGKAGQSKPTPAAVRVARRRVEEAEQRHRAAVEELEAAKRFEADELKRAALDDLDEEAGRRIKRQKTSEPEQYQPDFDDEEEADDDVEGPRMSKWETEVEGRAKDEGWEDLDEGDEDDPLMVSTYVVEVYEYLRELELTTMPDPDYMSKQNEVTWKMRGILVDWLVEIHTKFRLLPETIFLAVNIIDRFLSVRVVSIVKFQLVGVTALFIAAKYEEVVCPSVQNFLYMTDGGYTDEEILKAERYILGIIEFNLSYPNPINFLRRVSKADGYDIHSRTMAKYLMEISIVDHKFMSTPPSLIAAAATWLARRVLNSGPWDANLVHYSGYAEDELKPTAQLMLDYIVRTSPSLSKWAAAADEDGEIENPLEQSPEDHEFEHPNFIKKYGAKKFFKASTSTRKWAESEYAPVETYDETGMYLKAQPIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDC2</accession>
    <name>A0A2S5BDC2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDC2"/>
    <dbReference type="OrthoDB" id="10278281at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52108" checksum="1142A6B22FCF1B1F" modified="2018-07-18" version="1">MAPVQLGHLPHELKVKIADECHRADLRIAELMEEIQNRGGLAFDANPAHVRYDPYRRNRGGRQHRLDFPKAIAALYATSKDWRAIAAEHCFENLTSSQMTRPIFQLVIAPKYGRFVRNLHMSTSSTPEYCALWMGMFDFLPNLRSLQLDNPSELVQAIRRSAGDESADAATSILARVTTQVANLTLTATQALDAVRVFDMSTSMRSFTFTFLQPNGVSHLWQLVGKFPNLTELDVGMSFTDDRSNQSCFAALAKAVPVSLPPIARLAIQTASILGGFVDFLSLFVNTLRHLTLVFKSSHGGTRSATAALFSAMKPMLQLRRLDLTGDTDGLEKALRLFEPAALPALRRLGVFLIDGAKASAGLLEALERIAMRQVDLERIDVFPLKTTIGTWNSTDFFDEVGSARVRDNLASIESGSSSAGSSAILRMINKTLDYVNRTRDLAALHGDTVSYIRLAELLKPFDLERTLHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDE1</accession>
    <name>A0A2S5BDE1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2068</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDE1"/>
    <dbReference type="STRING" id="741276.A0A2S5BDE1"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="11">
        <location>
            <begin position="854"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="490"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="641"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="790"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="999" mass="98782" checksum="16C405FFDDA6B2CB" modified="2018-07-18" version="1">MFGSSGSFGGFGQQQQQQQPQQPAAGGGLFGGAATGGGFGSTTFGGAQSTPTFGQPAQQQTSTFGGFGSTTPAAPAFGAPASSTPSFGQPAAGGGLFGGGNTANTGAASTGFSFGSSGGATSTFGQPAASTGATGGLFGAPKPATSTFGGFGQPAQQQQQPTTGGGLFGAASANPAFGAAATPTGPPNGTAVAQYQTTTVMEPPQEEGKPPPANQTAHHFQSITCMPQYKNYSFEELRYQDYQANRKTPTAGAAPSFGSAFGSSGTPAFGAANTGTTGGGLFGSTSSTPAFGAAPAANTGFGSTPASGGLFGSAPSTGAFGQPATSQPATGGLFGAATSQPQQTGGLFGSASTGNAFGQPAASAAPAFGGFGAAAAPKPATTGFSFGATTTPAPTGGLFGSAPATSAAPSNPFGQPAQPAATGGLFGSAQPAQQQQPASTGFSFGSTANKPLFGSATPATSAPLFGQSAAASTAPKPTFSFGAAPAAGSTTGGLFGNTQQQQPGATPGFGQQTSAAPASGGLFGGTSTFGQPQQPAAGTNTFGGGGLFGAKPAQPATGGGLFGSSTAPSFGGGGGLFGSTTQAQPQQTTSLFGSTQQQQQQPQQQQFGGFLFGSTNAAAQPGQQQQAAYASADDANAYGSNPLFASVNPSAPRPVEDKKKPPIFSAFRGTPVSRSSTKITRLRGFGSTSTASPAQGSPLTIGGGLGVSTNGGSLVSPGTPGGRGSPLKLVNGLSDEVALSPNAFVSRPSVKKLVIDKKVLGRSSLGPGGAPAGDTPGRARVTFNPEAEVPGRSALFGTPARGTPAGDENEASFALSEGVTEGNTTIDSPSLAKSAASSEWPSRRPPPTPAAPKHGDYFTTPSLDTLQKLPVAKLRAVPDLVVARVGYGQVAFSQPVDLSTLPSLENLLGDLVRLEDRNATVYPDEFDDIKPPPGQGLNVPATITLENCFPLDKATRKPIKDKDHPRVQQHIKRLRNLDGTEFVDFEPESGKWTFEVAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDQ4</accession>
    <name>A0A2S5BDQ4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDQ4"/>
    <dbReference type="STRING" id="741276.A0A2S5BDQ4"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50286" checksum="DB78794467959348" modified="2018-07-18" version="1">MADTVKGPEPLTRVPEGPTPVAVPDDPSSRMTILASIWAIALLLGVPLWWRTTALERRTLPESRIQTWEANYRDRIPFLDRLSGKSLFKGLLPSAVTITDLSRPEDPTDGSAAAKFSRQYKLAFTLLNEDSTLGNAVLGWDAPALLQNSVVPLLDSLAPLHNFTVETQVQYFAPLAIEVHRADGQEGTYVDEADLRAFVNNAEWNLATGDTLDPVLQFLLFVPSAEHRPLRIRKHDGHYAPPAFISPQRGGVVIYNPPAPAHEQPPSIPLDLPTAALLPSFRTFERQLRTLLDVSVLVSSTSPIGARLSPAEVDAVALRRLRKAADDTVETLAATVRLASEIQNMRINGDVQQRVSAALDQLDEAASSDSVLVALSHVAAAQSLASRAYFDPSMMGMLYFPDEHKYAVYTPLFGPVAVPLVLALLKELKQRRYERKRGKKRPAGGTAGADEAEPPQPKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDW2</accession>
    <name>A0A2S5BDW2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDW2"/>
    <dbReference type="STRING" id="741276.A0A2S5BDW2"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="5">
        <location>
            <begin position="771"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="782"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="589"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="648"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="787"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="846" mass="92954" checksum="513A768F2996A40D" modified="2018-07-18" version="1">MAKGGNKKNLGARKATQYRAKPIDAEKPFDRSASRTRERRIETFEDTFGSGDEDQFHLNRDKLLLDDPYTSQQRRDGGGLDEPDAIYDLDLPESDSDDDNDDEEEEARPVKERVPRHLREYKRKDDGDLKTQGRFGHEYDPKQDVVFPDSDPDSDADDDDDDDKTLDSNQLSLAGGDDSDSDSGDKKQRRKTASDDDSDLEQDHERWAAGHYHVSRRAPGEADSEDEEALELEEKEARRLQKKMRDRLAGEDYGVVGTLDDGDDDEFEDAGGDADKKGAQERLRLDGEEDDKEKAESMANVAAAAATLTDEESIALLLRTQPETLALVDDFLLTASKLSQVSRDLAEVRRVGDGQGNDHPSLAIMELEHQALTTYLPTLAFYFSLLLQPAPGPNQDLVDKVVQRLSSLRGALATMDELDLTTAEYGANATSSDDDEDDDEDADEQEAVVAPSKRRRVVPPEEMFDLADSDASTQPSDSDDDDDEGEVITESMLDGLDDDELEELMSSLGPGEGADVLMERVRAKQREKGVPVYESGSGSDSGSGGGSEEEDNNDDVEMMDSDAEVANKLTAVQASNGRKQPRAVPTLPTLAPLSASAKTSKSARSSGSAANAAANDYLDPLALTSTDKADKASKRHTLRFHAAQVEQKASKRDARRRGLEGDDDLPRRSKEQARREVLKRQQHGAAKDAEARAKLDDGEFGDDDARDARVVRGEAVDGAAGGGGDDDDDDGYYDLVAAEKSEGRQAKKARYDGARAAEREEILSLAESSVDGPRAATRKILSNRGLTPKRNKLNRNARVKKRHQYDQKQKKLRSMQATYSGGEARTGYEGEKTGISRQNVRSRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDW3</accession>
    <name>A0A2S5BDW3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDW3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDW3"/>
    <dbReference type="OrthoDB" id="41588at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="360" mass="39408" checksum="A99C116E90641B45" modified="2018-07-18" version="1">MATYADARLRIQALSNASAAAIVTSKRPRTAAAAPFPSSDSTAAATAEQTSLDDIRNDAVVHAQGVSKEVTALTLALRPPVTELAVVGTLDKLGDILAKLAFIVDLLTRYDGALAKRVSWYILDVLETFQHFLPYATAALDKVPSDRQQKARNELLRSAKTVWTTVDKADQLPQTELAAERQGWRDAITMLDDCLEEMKDLEESIEGGDDDKKEEEEEDTPAAEGRTEQDASARPASRQRQRVNATRHLLRLGRLLVHRLVTKTATSSPAFADSAFLSQTRNLTSRMSALGDDLALELEPPQEGLVEAVDDLCQVEDELADLLEAAVTARGSDELRASEGEWMATWRKQRTGVRSKLDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE17</accession>
    <name>A0A2S5BE17_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE17"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="245" mass="26720" checksum="6A18DB8BD4B313BA" modified="2018-07-18" version="1">MSAFTYLITGASRSLGLGYTRQLLQSGKHVRVVAGARSPSSAEDLQKLRKEVGEDRLYILKLDVEDSAQVANSVKELESSGFLKDGALDCLINNAGVARAHSKNPSQVTPEDVMDNLQTNLFGVIHVTSSFLPLLKKGKGKQIFGVSSTCGSIGGPFGENQSATAYCISKAALNMYSRKLSRELEKDGFTVVVFHPGYVKTDMNSGQGDLTTEEAVRLATENIFLKLGQEENGSFWRYDGERMPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BED5</accession>
    <name>A0A2S5BED5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BED5"/>
    <dbReference type="OrthoDB" id="2529965at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015770045" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="24543" checksum="88DF53A54CEE4E54" modified="2018-07-18" version="1">MPRSFASTFSSPSAWALATVLGLAASRVAVAQTAAQISTEQNTLSTLIPGACEASCTAWLTALAACPAAASATYSNCVCDATFVANFQTCAPCLATQLTAQNDAADAATANQAPTDLTNFCAAAGTSLTSATTTSTTSTTAVTATAVTSAASSGAGLNNGANTIFTPTTPLLTFSTVSSTSSVNLASVGTSVDTDLGPKTITQSGQNLPFPTQSKGTNAFASGAGSNVRSDKSAAVAMALVAVAGGWLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEH9</accession>
    <name>A0A2S5BEH9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEH9"/>
    <dbReference type="STRING" id="741276.A0A2S5BEH9"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1050.10">
        <property type="entry name" value="Ribosomal Protein S4 Delta 41, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="133"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="195"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="329" mass="35756" checksum="E51A7345D76B3649" modified="2018-07-18" version="1">MGHVPANPTSILKCLPRMYEGSQTLAEAAAVEHTPHATRTQNFRSWSPANLYNLYQRTYGPPSNETRFTKSSFTLFQQKWKAKQLVRAYHGDILIETKFKRHYLPDELPPIVGTQPGDLPVPLASLMFAQVEKRIDTVVFRACFADSIYKARQMVLHGKVSLNGRTMTDPNRKLQPGDLVSVEPSAVVTLQRPQPASGDASATADTSAGATSADAEADSSASTSGASEPAAAAASSPSASSPSARPLPFHLPDFAAPFLFIPPYLEPSFQTCSVVYLRDPTARPGVSEVPSPYEADGEVMRLAWEYYLGMGRKGDVKKSKKVRGQRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEN3</accession>
    <name>A0A2S5BEN3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_1605</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEN3"/>
    <dbReference type="STRING" id="741276.A0A2S5BEN3"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="59"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY75235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="252" mass="28851" checksum="E1DC72D6814DAF56" modified="2018-07-18" version="1">MASTSHTITLDPTKYDQEQINLMEERLILLDNNDSAIGEGSKKDCHLIPPPGSQDTRSPLHRAFSVFLFHPESGKLLLQRRADEKITFPGMWTNTCCSHPLTSNGEMDEENQIGVRRAAARKLTHELGIPHSYPLDDFAYLTRIHYYAPSDEIWAEHEIDYIFFLTLDPKYEVNPNEVSDTKWVSKADLEAFFQDPASTFTPWFRLIAESFLYKWWDALLASRPDASVALDAKALVAEVEKEKETMGQIIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEU1</accession>
    <name>A0A2S5BEU1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEU1"/>
    <dbReference type="STRING" id="741276.A0A2S5BEU1"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="80"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="576" mass="61613" checksum="6623CD7F35900974" modified="2018-07-18" version="1">MAEPPRKRPRLSPPPASPKPTPPGEPSRTISASTTTTSAAAPAAPAATLVETLKSDQARTLASHQVHEPSHYSHRVTPFQQPLHLTSFSYSPTRQLLLDSHNRDDSLSYYREPRLGSDLNHGFDRAVWRDGTVDEGLDALLDTLDHWARSDPSGAAADLLAKTALITWRGMLTKLMLAVYECDNLAHGRRADGWEMNAMLVEDCLYLEESNPPAKLAAKAESERSGPGALPSYYGYSFEAYCTTSAPSRTLSNPHAPPPPPSRGPDEDDGFSVPNTNVQWCSVVKTSLGGCRTIVGGEVDCLRPTADMTRGVSTNDFIELKTNLVIQSLRDEINFERQKLLKHYVQSFLLGVPTVTVGFRTRQGQLANLQSFNTLDLPRMVRGKPHAWDPSVCLTSAHDLLDFIRRTVAAAMSAPANSSESTSPSSPPVFRISFSPHATPSSGSFPTVTIRQLTAELVESEVVGGKKAVAGGRIGFLPRTWAEARRAHRVAASERGTLTAHTASSSLQAKPRPAQSRPPPPPPPPPPPAGAVSNPTDSASSAAGMPPAAVDSPAAPSMPKSTSAGRPGGVAALLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEW3</accession>
    <name>A0A2S5BEW3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger ZPR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEW3"/>
    <dbReference type="STRING" id="741276.A0A2S5BEW3"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="38"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="262"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="423"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="491" mass="54137" checksum="7FC9DC2353F629BC" modified="2018-07-18" version="1">MSATNDTPAAAQAPESQWRPIGEAVTGAGDVPVEVIESLCMNCHENGETRMLLTVIPYFREVIVVSFRCEHCGHSNNEIQSAGQIQPLGAIYTVKCTDRDDLDRQLVKSEHCTISIPEYQLTIPAGRGQFTTVEGVLADTVRDLEHDQPLRKIQHPELHDKIAELVAKLRQIVPDTDKDDDEEQGPTASTSTPPPMPTFTLKLDDISGNSFVETRGGLQDSKWSKREYGRDKQQDEQLGLQHDEAQDKATSHYAEEVLSFPGVCSLCGSELETLMKKVTIPHFKDIILMSTNCHDCGYRDNEVKSGGAIADKGRRITLKVEDSDDLSRDILKSETAGLTIPEIDLELNPGTLGGRFTTLEGLLQQVYEELDEKVFARGDSSVAAAAGEDSEMARFLGDLKKAMNVEIKFTVVLDDPLANSYIQNTWAPDPDPGLTEEDYERSHEQNEELGLNDMKTENYGHVDVIEGAEAEQQDGSTKPAPQDDGKPIVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFA7</accession>
    <name>A0A2S5BFA7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFA7"/>
    <dbReference type="OrthoDB" id="2519410at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37536" checksum="FB33DB9066478BC3" modified="2018-07-18" version="1">MPATLPLELQLYVVELAAPLHEFTRRPETLKSCSLVHRSWTPTAQKLLFQQIERILDAACSQPAEWVVDAFEDRLRRQPETAPIGLSLMVDDVCECIPGYLASSVNAQLEILAVDCHRSFILSHLQSFSNVRIMRITGSNLADYQMVLDLAAFAPAHPHLEELGFSDADVTLEEQGISPCLSLTRLHLKNSTLRFQRSRLQHWVPNLEVLIASNSEPDHGAYLSLAVLSCLPPKLRQLVCGKSFDSLFNDLFYLRPVQLPATLEFLHLIVYAETNRRGQLSLDDAGNLDMMHNRVRTCTGGLSLVIKLDWISKRKKSADELCEELAERCELVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFD1</accession>
    <name>A0A2S5BFD1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl transferase 64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFD1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFD1"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="4">
        <location>
            <begin position="686"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="988" mass="114356" checksum="D0EF6D3EAC118F77" modified="2018-07-18" version="1">MLRRVRTGSRRLNRLALLLLVGLAGTWYLKQRQSFNRRGVEICLVGNAETQDLAWKVYDQWDRAFPATFYVWGDKRVRSERRLDGGRLSLLAPEEGQDALPFADGMYSAVQLVTSRFQCDYIFTHDDDLEFKLAPHASFYDETSPSNGLVQELRHVVGKYRPAIAGFPWQVGDERFDEMKALKAIYGLEEVAPLTGFDNGMVVYHRSVLPLFFPYAPQGEGGFNGKWTLGAHFLQLFGPSVFREHALRLNTFMYDNTVNMDNVPKGGGVTTVKDGLAYVPASRHPYEYPLNEAYQSFLASGLHDRSQRWGRQLDVADVSAPAIWSGGDYSADWILDRIDDFYDVRHEALSRTRLIQSVSPETLADFSVQIPPMLTFRIILFTKNRLKSFARCWESVRAALPIESEVIVDVRVDLDPDMSRRDEVSYSDYLEAMELEPGPADEVHITRADRPLGLRESILSSWQPTANHEFAIFLEDDIEVSPYFLQYAENMVRAYVYRDRADSRLVAISLYNLRYNEAREEFVQVDNNHEPFVYQQPQSWGAVFMPEPWRQFKSWLTNFPWDQDPIVPNSLTNRWPYKKSWKKYYIRFLLERGGYLIYPNLPEGLSYSTNHVEVGTNDKPSDPDARAAIHAKFKVPLLQREDDMSRMQTYPRLENLQVLTLQHERRMSIDDLPRGTSDISTFDKCTLIIPVLSRTGTIHERLDYYHQLERLGQILVLWNKLELDPPLRAYTNYSVPVEVLRMERDSLNNRFYPWPQIQYDCVINMVNWEMPFEHLRYGIDLWRGHFWNNLIGFSHQGRNHVVREVDGASKTMYSATFISPERLAGKKSFYSLVLTSGFICHRKYLEMYSNELPKEALAFVDKHMNGEDLLFNYMVANATGMGPILVEAWATPIADQNNAGLWSRPTHMRARTEALRLFERLFGSNPLKYTTSLFPIQHETTPPGLHHYTMSETMPFAYPCNRTVYDAQGQCALVIDREYWNAEGGWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFM0</accession>
    <name>A0A2S5BFM0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFM0"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="67946" checksum="F81B1C6F509258F5" modified="2018-07-18" version="1">MALSPTIDKERVRRRETDRMAQAESRAQPKGRPPSAAIRGLAICTATLPLWYNNTPYAILNPLFSSAPTTAIPPRVVAYMVLFTVFLATRVFPVTQSDASWRTCWLVIALWKLVSPALLEATAESLLRLGLEHGIIAGRILLGGLSTLAIWTWLLNSLTCIERSRLFPPYVLLALYAGSFVSHLEIFSFTTLPECYTLHVHGLLLAAVALFAPCLEHPVQARGRPHSNHPFAIMNASASTKTATLTLALLVAFVASRMSRHCPLSPAEPDSTGILASRKSVTGWISVGEHTMPQADGARGDMTMRYLRADHSLLGGLWIGPSRDTLASKHGAQLNNERAVVRYAESIYSTFILQELVRLVIRPAELPHAAPEQGLIIGLGAGLSARALAQHGVNLTVVEIDPVVYDFAVEYFAVDDAAMGEVVLEDAVAWAGRQDRPGHFDYIVHDVFTGGAVPASLFRLDFLQQLSTLLHPTGVLALNFAGDFNAVSSTMILTTVHRVFPRCRAFSDSETSSAYSNIVILCTKDWYVGLELRDPVQADFLPYPSPAIREQVLSRFRSREVDIARFKRKADSVEGGAWLIRTDGDVRKVEREQLQDVGVHWTVMRDVLPEKVWARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFN0</accession>
    <name>A0A2S5BFN0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Redoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFN0"/>
    <dbReference type="STRING" id="741276.A0A2S5BFN0"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Redoxin" evidence="8">
        <location>
            <begin position="58"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="268" mass="28810" checksum="C2585A7C32CAD806" modified="2018-07-18" version="1" fragment="single">LANVGAAPPFVSSPSPVLPGGLVGTRQALSCRTRTDLTGRPYLLSHNSPQSINMTIAVGDTIPDVELSYVPYSPELEDPSVCGLPGKIQTGKDWKGKKIVLFGIPGAFTKTCSENHLPPYVTSYDQFKSKGVDAIVSTVSRLWRRSSVVDPKHRFRSTASPPSEPFRLRVSTALYLITDQSAWRVSDLYVQSAFGRVMKTGDKVICCADPDKKFLGPAGLVQDLSHVGFGERAKRFALVIDDCKVTYVGEETGPGVGPSGAEAVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG74</accession>
    <name>A0A2S5BG74_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG74"/>
    <dbReference type="STRING" id="741276.A0A2S5BG74"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="350" mass="38598" checksum="DB22A029481B8054" modified="2018-07-18" version="1">MADASDLQLPAFVDSVSSIVFHPTNPHLLLVSSWDRNVYRHDLRNASEPRKLGLRGALLDVAWAGTSEQVAYAGGLGKEVRSINYESQETQLICRHDDAVRCVEFSQELNAVISGSWDQTLRITPIDPTTSQPWPNPTVLRLPHKVYSLAISATKIVCAMGGRHVWIWDIPQLKRQLEEGKTGDEIEPWQRRESSLKFMTRAVRIMHNDQGYVTTSIEGRVAVEFFDSASEVQAKKYAFKCHRQVIDGVDTVYPVQGLAFNPHWGTFATGGGDGTVSLWDPVAKKRLRQLPKYPAPVSALAFNCDGTQLAVAFSEEDEGGADGGKVMPPGGGNGVWVRTCGDEVRPKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGN7</accession>
    <name>A0A2S5BGN7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGN7"/>
    <dbReference type="STRING" id="741276.A0A2S5BGN7"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="12">
        <location>
            <begin position="55"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="306"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="418" mass="44928" checksum="C48C684312619B6A" modified="2018-07-18" version="1">MASAAPSAEQIAQATFSLANNIQETDEIYKYDKDEQKAVLNARAWKQDPHYFKKVRISAIALIKMVMHARSGGQYEIMGLMQGKLDGDTFIVMDAFALPVVGTETRVNAANEANEFMIQYIESSPAVGRPENIVGWYHSHPGYGCWLSGIDVMTQKTNQTFQDPFLAVVIDPNRTVSAGRVEIGAFRTYPEGYTPPNASASEYQSIPVDKIEDFGVHANSYYPIEVSHFKSSHDAKLLDLLWNKYWVMTLSQSPLVSNRAYATSQLSDLVAKLRNTEQSVGHRCNIGQLSPLIVQIRQQLANGRAAGNANGSLGPISPPNKNASPSKASKGKGKANVEQDAGPDANDGTGSAGGSGSKSDETPLARVVNDATKLSSEASHGLIGALVKDALFNGGKLAHPTGVGAGRERQLVLPPVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGQ1</accession>
    <name>A0A2S5BGQ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGQ1"/>
    <dbReference type="STRING" id="741276.A0A2S5BGQ1"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="152"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="386" mass="42745" checksum="AE708AC1358400AE" modified="2018-07-18" version="1">MSAPATCRWGILSTGWIAGMFVKDLLVDPETRGVRDIKHEVVAIGSRSVESAQQFVNQWWPDVDSNAHKRIKRHGSYAELFRDQAVDCIYIGTPHSHHFDTAYAALQAGKNVLVEKPMTVNAKQAETLVRLAREKGVFLASALWTRCLPSTLKLQEVLASGAIGEIRGVTSEFSIDATGLVNRDPGHRMVNPELAGGALLDLGPYSYTQLALVLAPHGRTSYDKLPEISSSMVKTSTRVDASTTATLHFEQSDGRIVAGTMTSAIDRHTPPERCVLISGSLGYITIHSPANNPRSFTVKRYGDSHRFWTHETEHDATTYNFGMPGGIFGFAYEADEVARCMRDGKTESELLPLDETVYQMKIFDEIRRQNRLEYPAPIESFDVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH18</accession>
    <name>A0A2S5BH18_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Long-chain-fatty-acid--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH18"/>
    <dbReference type="STRING" id="741276.A0A2S5BH18"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF393">
        <property type="entry name" value="LIGASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="493"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="65792" checksum="D602078796C65133" modified="2018-07-18" version="1">MTYRPAPPKRTIQETNELFSAPTSPFAWEVKTLGKRTVKCYRNLPPSLGQLWRTAAATFPDKEYIVYEGERIVYSEANERILKLASLLHETGVRKGDRVAIAMRNLPEWIISWWACHLLGGIAVAVNAWLPPTAFVHCITITEPKVVLVDEERQALLGPRVAELRQHGCCAVFSVRTQKVVQGVTRLEDALRQHKTQEVRAAEIGPEDLGTIFFTSGTTSLPKGVISTQRQFLTNRWNTATGPARALLRKGESIPAPDPNAPQRSVLLTTPLFHVMGNQSFLTLMTSMGGKLVLMYKFDAARATELICTEKLLSAGGVPNLVAQIFDEIDRQGRWNEVCLEGVSYGGGPPSSKLPSATKERLPNAMAGQGYGLTEVNSVATTIVGDDYIMRPTSCGQAPPVVSLKIVNPDSKAPVSQQAAYAAGKIGEVCIFGPNVAEGYWRDEEATRKAFDEDGWFRSGDLGYIDDEGFLFIADRAKDIIVRSGENIASVMVEDALSHHAAIKEAAVVPVPCEIHGEQVAAVVLTRPHHAVPTTKELQAHVASILPKHCIPAMILFEKDDMPRNGTGKVLKNELRTSAHREWERRGLGRGKNGEGRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH61</accession>
    <name>A0A2S5BH61_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0841</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH61"/>
    <dbReference type="STRING" id="741276.A0A2S5BH61"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="7"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="212" mass="23763" checksum="0CA99C5E9EF3DEAD" modified="2018-07-18" version="1">MKILSIQIQHIQPGSAGASNAVAIAAAQDLSSFSFYQRGTVGEFLNFLSRTVAERTQPGQRQSVQENNYTAHAYHRSTDSLAGIIITDQEYPVRVAFSLLNKLLDEFTTKVRKEEWEDKARQGRQAGKQVLVDYPDLATYLQKYQDPKQADAIMRVQQELDETKIILHKTIESVLQRGEQLDSLVDKSAALSASSKSFYKTAKKQNSCCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH64</accession>
    <name>A0A2S5BH64_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="15">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_0825</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="15">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="15"/>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH64"/>
    <dbReference type="STRING" id="741276.A0A2S5BH64"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="164"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="354"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="578"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY76102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="667" mass="73099" checksum="9EC02A1BD8AD0DDD" modified="2018-07-18" version="1">MSATSAPVASTSSAAAIEAKKRKRKRSHKKGNGGDATAPSADEQAAAPAPVQPDDDDVEPLIEPEFEPAPEETAAERKAKDKKRKGKEVTGTPAGFEVEEEHQNGAANGSGDAATDALALMTGAKPAPEPKSVAFSSLDLSDGTRKAIEGMGFAKMTEVQARTIPPLLAGKDVLGAAKTGSGKTLAFLIPAVEMLYKLKFKPRNGTGAIVISPTRELALQIFGVAKELCEHHNQTYAIVMGGANRKAEAEKLAKGVNLLIATPGRLLDHLQNTKGFVFTNLRALIIDEADRILEIGFEDEMRQIISLLPKDKRQSMLFSATQTTKVTDLARMSLRPGPLYINVDTKSETSTANNLEQGYVVCDSDKRFLLLFTFLRKNLKKKVIVFMSSCKSVQYHAELLNYIDVPVLDLHGKQKQQKRTATFFEFVNAPTGILLCTDVAARGLDIPSVDYIVQFDPPDDPREYVHRAGRTARAGKSGKSLLFLLPSELGFLRFLKAAKVPLNEYSFPASKIANVQSQLEKLIAKNYYLNNSAKEGFRSYVQSYASYSLKTVFDVTQLDLAKVAKAFGFTTPPSVSINIGRSAKGGKKRKDRNGVDSDIENAEDSSDEEDDDEAENERDRRAKMARRGGTNQSKRREVEGRKAEKDFYREQGREKLQKNGGSTQWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH66</accession>
    <name>A0A2S5BH66_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH66"/>
    <dbReference type="STRING" id="741276.A0A2S5BH66"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015536191" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="3">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="927"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1274" mass="134160" checksum="616D8290FDEE8DD9" modified="2018-07-18" version="1">MRPFLFGSLLAALFSPIVTVLAAPTLVYDLQAQRPPVARTGSNWTFALSPTTFSPANASLSLSTTLPSWVTFSATEKVFSGTPQSGDVGSTSVSVTATATDGSTTRASFTLLVVDSASDPAPTVQLPVLQQLAAAAAVSGGGTLTPDGSLRVPPKWSFSFGFEWYTIQSPTGRSLFWTAYQKGTTSLPSWIQFNNGTMTFNGLAPNPAQKGTWKLMLGASDVYGYVDVWQEFELVIADHSFELLGSNAADANNTLAQGVLPAINATIGGPVKYSIPFAVFRVDNATLTSGNLSSATANFSRTTLGPDALRLEADSSSALAIVGTIPSTANASASLGPVELTLADAYNDTLTTNISLRLVPSLFDSSKFPATVGVKEGSVYSEDLSRFLATTGSSRSKRSLPSTLATANMSLSVTPASAASWISLDSSAFTLSGKAPSSGTNATAVLDIIDPATNAVSRATFLFAVSPNGTGSTDPGAGSGTAGHRGGLSHAAKLGLGLGLGLGLPFLIALLVLLACCYRRRKGSGTNSKPSGDGRNAKRGGLLNGLVISQPRPLSAGAASHGTDPHSGFGSSTVTVVTPSHDQERKQAEPISEKPLNASPVIGTAWAPGLPTVTAPIIARVEHDSPQRARRFDVMGMLFRSESGGSILDSIRRQKLKGKAKEEAPPVPALSADRSSMYGLGLGDHDVIVVADGGRDSLDDQRKSTYREVTSSPHGSAGSVALAGGRLRDATGLSGSGRVSSWESGASSSLFYASSTSKSAMGSTGPHRRTASRSNSLGSHASFSSPSSSASGGRRGVSSVPQRRRDFMPIGAHGRLASRDSSYDAVGVFLTENDPTDESSRLYHHDASVARLGSEDPLDEIRIVGSHSGSTSGSSIPFHDRTNRSAAPGYPESSRDGSFPATEPSQDSLPPPRFVPFTSERRSAPYGQGFASQASLAAAQSGVGTETAEDEHFDDDAVEDAWESDGEFDDDRPRPRSGVYAPSGDIGLPATAPVYYPSGSAYSRTSFDEEHEAVEEEEEDVHRLGPGGVRYVGSVASTQVSPQLHSSPRDSASHYSREPGTPRSDIFSIASSQPTAATSHGHNRASDASNADCNQTTWAQKRASSYLEPLRVPVNIDEPFRFVPRLDPPPFASITSSPGRNGPPRATYAAWIDLSRLDDDEHDASTDEGARGLAPLPDFVRFDADRIEMHGRAQPEHAGTWPVVVIERKSQRTPGSPTRLRTAREREEDDVQEQVVGRFELVVQPRDEYGQQETLHGNGNREEEAAGELRFVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH81</accession>
    <name>A0A2S5BH81_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH81"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="726" mass="78337" checksum="812108AF76BE4FB1" modified="2018-07-18" version="1">MTFGALAAVGACVQIVKTLYEYYNVHSRNKALLDILESFSQNLEISIERLQAREEMLGFAQNDALDSIERDFRKAKEWLLANDKNLRSIWTALQAADKLKDLDDRLTKAFASKMSVAIFSALQDTRAGVARIETTLEGLPINLEMVCKTSTKEAIHEAIGELKAEAYAVAGGGEGPGRGFVNGEAEKIISQLVDQLAEQERLKEDEELMLMSTYPTLDPLAISSAPPVPYAPASSHAPASSRGVPSEYSSHHDEPFEPAASKASSRFSRKKSQQTLASTAMTSEGGDFTESADAAGLAFSPIDLTGADIVDPVLASDGSIYDRWSLVNGPPRFSSVPPEPLTIVGDVVQLREKLFAAFPERKQKFRDLRQAYRLATLRLYKSAAFTDLPELLGRLSNVLRYEPNSISLHIRRGYVNYRLRFLEAAVADFQAAVEQSKLGINGEKDRHKADVDALRARALALAEMHRYEDAKLDIETVLEQSPRDILCLSLRASMAGNEGDAKSARADLAATNAAVRAGRAFRSRLGDEDSDLEYLARGWAYCSVGDFGSAAADMAFAAGLRDPIDPYAAACQALALIKEEEGRLGKPSDETTITCAAQLEASLGVLQALVDDGIAGARTGISSSGAVAITAVEAGYPVCAYPTLLLRGSARAAQGDTQNALRDLELALRIQPACVQDDSGVLCAMAELYFASGERDKAQRAFDRAIAAAGRGTRAAIIECREAHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHH3</accession>
    <name>A0A2S5BHH3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000007">
        <property type="protein sequence ID" value="POY76204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHH3"/>
    <dbReference type="STRING" id="741276.A0A2S5BHH3"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="147"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26067" checksum="BFFB103D9841E637" modified="2018-07-18" version="1" fragment="single">MTAISRPFSLDEEVRLSHSNADRERIAELANLYSLILTLDYLERAYVRDSVQAKEYHPKCLKLLQQYKTIVNLLGGTGNVQLDQFMLEYRMDCTAAAHRLRVGVPATVEHPGGDHRDDSTTMTMTGSHPATTTPQGGGGGGPGSADETAKSVAETTQNFITFMDALKLKLRAKDQLHPLLTDLMQSYSRFCQHRTAPSEDGEWEGRPKMLAWLIRLNQMRASEEISEEQSRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHZ4</accession>
    <name>A0A2S5BHZ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHZ4"/>
    <dbReference type="STRING" id="741276.A0A2S5BHZ4"/>
    <dbReference type="OrthoDB" id="2529778at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="680" mass="70797" checksum="CD6D09AC2B03CA08" modified="2018-07-18" version="1">MAATASAPIRIQRPTGAPHILVSSPPSRPVSPGPPPPSPASVSRVVAPRRAVFDLRSSSPLSPSAGDKTLLRAQLERAKQNRVLLRSGKKARPLSQRELRRLAAEENGESSPAGTVDGETTGSLTPLSLSDSDRASTVGLIGCIEGMLSAEESPQPMQRPRVSTDSFPVDSDTAATPTGTVPPESAASSDNAASAEQSPANSPPRSMSRPPLSHRISRTAPTTPSISPTSHISTLLSRRPSVKVDLSTAFATGLVVSASGSGSTASARQALGKTHSLPPGSAVSATTSLPGSRRSSVPSSPLLTPLKLPFSRPPSLPSPKASTPRRRHLSAGGSTSSATSPISPPAKQSVMSSDPRDLTLQFTRRNRPDIGPRTLSTSSVSSLLFARRTSHPELEEDCETTEPDDGSEADDNADTTQTGPFFEPSVFASPPLYTSATSYKSTGPSRAGSTSYWSIHSSASSQHTRAPTASSIASTQSRISEAGSPGHRRSDSALSKSRSPAKIVPQPTGLVQAIPLSPVVPLDAAWLPGPLPPQPSQLSLAHPARMVQQHQQQKWLAPPREAASASVKASAGVDLQKLRREQLARRRAVEADELNGDDSSSETAPADDEAEVVAADEPPALGRASPAQERKEASSWEDEHPVGGPSRAVGAVAPGATKPGGRRSPLLLRRTSAKRGGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI46</accession>
    <name>A0A2S5BI46_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI46"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="326" mass="34618" checksum="41CC8263AC2FFE50" modified="2018-07-18" version="1">MEAATNFLVKRGNDALALNPPNANLNLTTHGSDWLWAVFSVMALSAIGLLALGHMTRPVGERAFHELGAALCATASVAYFALASDLGATPIQVEFLHGSQLVNGAYPYRQVWYARYIDWTITTPMLLLELLLTTGLPLSQLFIIIFADLLMIETGLVGALVVSRYKWATGADGILFEGFFAFGCAAEIFIWYMLLVPGRASAARLGSGYSKAYLMSASILSFLWLLYPIAWGLCEGGNVISVTGVLDLLAKPVFSFIHVFAIAKLDYARLGLSSGKVSDGAHQGLLSEKSQHVDATPRPSTATGVTDGVVGNGAGFHAAPGATSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIA8</accession>
    <name>A0A2S5BIA8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIA8"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="262" mass="28998" checksum="CB025346CDF02998" modified="2018-07-18" version="1">MAELAKAGLGAPSVDPPPLAHPVQHAQLVRLCQEIAAGIDEKHPLFPGPGSAWSEAMLAEPICSSDAWLEPDRVARRKHYALAWSLLELEHQISQCTPDETDDLLGNAGSPAAIKAAQPEWVVLLEMATEQYNARAGQERKERKERKRAAHAEVPENLSDEEGHHREVEPTSDAEASSPAQGHHERHPAFNVRARANSYSGPAHDLGPAHRLLPPYQQRVQEDYYARHQLPPPSYLQSLQTEEPSDWGSHGTGDRFFPDSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIS6</accession>
    <name>A0A2S5BIS6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIS6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="725" mass="80395" checksum="71751EF9ABC53933" modified="2018-07-18" version="1">MADPLPPEQTYTGAQQPALEEEQKMNEDAAPAFPADREPSTSPTATLPFPDELQRLSGASLLKTLIDAADTDEIKKYWQRLPGAVADQSVSNEERDKHHARERKIVAKVKKILAKHPDRKTGAPIALPEREFIDSTGCVDATLGSSWYYGVPSVNLSKVFNTKGSPTFRLLDDLVPQPRCDTFFSDMHRYVSPSQFNRNDGATVKEPWLSTPHVGPQAAKDVYGALEVYNHKNHRLRAFPPEGELRFTILNGREVDAEFLAAMEAVRDSNEFDLIERTYSIPFEGCQLANGAFADDGEREQRIYFVRDVLENEIISAFVPLDHMSYYLYGSSKAYGSARVTELFYSLFGDLMRIEHRRAGLPRQSDEVANVSSGLGIQAAAQGIAELNPGLPVLELIAPFLEPKYPPVETGSPLSAYLETSTSTIRVSMQTLTHFDNRTPEEKAASARKGAESKRKTDAARKLQGLPTSAEKGAETMQKSNAELAARGLPTSWQRGAVTRLDREAAVAEAGGETSWQKGAAVRREFEIALTKKGLPTSWQRGAQKREENNAALAEQGLPTSHAKRILVVHAENEERKLRNEKTTYELRAITLAQNNAARRDAGEKTSHELSRQVLRERNAQLREDGKKTSGDLAAEGLARTNAKRTADGDPTSHEKTAKTQRMDYEAQQEEKRLRPSKEAVAAIRRFKTSAEWAADYKRCNARKAEFRAVGGYIKGVKSAAVTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJA1</accession>
    <name>A0A2S5BJA1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJA1"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="233" mass="25739" checksum="10B02CAD45F95B56" modified="2018-07-18" version="1">MAQVTEAEAQRIVAHMNKDHAESLGNYLEHYGHVPRSLACASPALTSFTTASMKISYGPAKSRREWTHEFSPPMYAGEARKRLEAMHQDARKGLGISPAEVDRVVVTVPALISLVVYSSVLLAFSVPRPETIASAFSFQAQYLSPLLASIGLKRAYEPRTIGRVISLFWTGILLVAHVAEAFLCLPPLFRSYNVKSRSVQLAYVVLTVVGGFPIWQGLRDKGIEEERKLVKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJC9</accession>
    <name>A0A2S5BJC9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BJC9"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1787"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1166"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2040"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2041"/>
            <end position="2063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2086" mass="226227" checksum="27C7F0E54EF283BA" modified="2018-07-18" version="1">MSLPDSVEGAGSSRSPSNYAPSVVSHRSEEASTSAPTFFKSIKRAIAKAATAGSEPTHHDVKDKGRVATSSRNAGVKPKRSATATEIPVTADAAARRERAAVAPGTPASNYGIAGPSRGGFIVQTHSKAVPTVATTTGDVTSLDDLPPLSLPPLATVSTRELPRKKPTLERAISIDVLPSPTATQVSTDAVDPHLPPSLVLARIAELAAKNPRLDEFAPLIRSLTTSIDIFPFPPPALAAKRLSEALASHTPSSYLYRGTEEYVAPTPSPARLYLSQAHLLRPEAPPVLRAAMLELMVASITASLESTGGMGEAEKALFWEEARRWADEARVEVDDGQGGRRYILPDLDREALVKVLAALTRGGRDLSEVPGLVTLLCTIVIEALPVPRPPSPLFDTKLSTPFVRQVPHRPAPHASALALLVALHKFSAPHIYTTSTLLALRAALEVAKLREEQDIGGRDGVLDLLGAVIRYGEVTGGKAARHRAILQPKQAQPDPDLEMTLQEGDEILREVVSCVARLIGCEGLVSVIELKEGQSLQDVKKSANSPAVKTSNLPALALDIMRDLIRSPANQATKSLRSALIGPPVSTTGERPPAPVLLLVGTLRSLRKAMAEHSAEVEAVIAETGGLGNSMGTSGGESRWPSMLSLGLPFLWNGIKRVMQWENEAIDAEVLRLVEERLAAAESAERLAEEYVAAQAPAAGASAPTAPKEAEDIPRGVSYEEWTMAVEVLDRAKVHISLWEQKNLKQWILSDEGKLGDLVRIGVPAGKADSEESAASPSDERPPQYRQAGPDRGRRDTLPTPNASSHFLQRPGVLVAFSSLLRKVVRASCSDDFTGPADAVFSLLLSLAPHLSEDYAHLTLEQARVGMLCLPSHPEWLSRAQQLVDAFYVAPSSRSATGPRSLRRNSAPLVRARIVESLATIHAHVRFLPQQRRALVKQILLPLVETSLEHETDVAVTEALVSLVVEIARDTLDTPDHAGEEDRHAISFEHLQSLLIKLAKSTERGHSRRLVSSPTTPTSRRNASFTPLSRGDRSPVAPTRVPSLSYPQRSDSDGPDVSSVAVLGLMTVFHLCLDHSTAASATKAISLFRELLALFAPGYDGMHDPDVDGPSQVSLRVRLLILQWLVRLRADASHRINWTEHVDISGAAKTLGRIAEVGSYELAIPSTAQASEDGHGEQRGRTSREPSTAIRAGAASGVGEATTRSRSASRLRRQLKEDRSPTRTNSLRRGTAAIANTSPTLWSVPEKLSFDFGLAVAATGSKALSSFDHKRMRNWTEEEDPGTGAMKIVEADETLPPEEWMPVLPVSEYLQALLHVLGVDQEWELVSYILCHLPEQLSNKHFACGPRCAQQIHALRRLLCEGLKAGDRGDRVFPSALPGGIKRAEIHAVAYQCLTALIAYRSLFTKQQQDDIVTTLLHGLSNPRDTAKPCIHALTIASFELRPSMTKLLAETVRHLQKIISSATLGVHILEFIAGVGQEPALYANFTDVDFQTVFGIALKYIQAHNERLADKPDDVDEGIEYAFSQYVLLLAYYNIAIWFLALRLPDRPKVVPFLTRRLVQANEGKGDVDEATEVALDMIARYTYSNADPRPRASKFDELITAPQSSATALPPPKTWVVGTGTVTIRKVRAPAWVEVTVRRPSGVVRMMWELQNIGMTSSAPESDLIAALFRHRETANVMHGLNSTIRDALEAMPADETNLPRPVRARSASFHGSTALDVHKRIELNALADVANSAAQDVQQITMESGALTVDPGFFAIQMSSYPHVETAIRPLLVPSDPASQRAVTMLDTIPIVDFHKIGVLFAGPGQTNEVDILANQQGSKAYVEFIAGLGTLVRTQGSREFNIYTGGLDQENDFDGKWTYCWDDDISQIVFHVATLMPTNRETDAQCTMKKRHIGNDFVKIIWNESGGEFAFDTLPGDFNFVNIVIQPHTPAGNPWIGPGMSNNTDFFKVSMQCRPGMPEIGPLGTFKMVAGSSLPSVVRQLALHSNIFAQIFLASVGFETGRPAGHSGKTHRIEYSSNWRKRLQQIKMLKQRIRDASAAAARSEGSASAAEPAGPSADRQPPSSPVDLDRAEAARLFTAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJD1</accession>
    <name>A0A2S5BJD1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide kinase 3'-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJD1"/>
    <dbReference type="STRING" id="741276.A0A2S5BJD1"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01625">
        <property type="entry name" value="HAD_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="53406" checksum="5AB1C3DC6BD756EA" modified="2018-07-18" version="1">MDSRPSKRAKVDIDLTSDSNSATPAERVSPATVQPAGLSLSPPAPPVKKPEIASIFKPNQATKGKWLADVRRAKTSTPGGMGHFVYDDPRPSAKIAAFDIDGTLITPRDGRRFPKNETDWQWLNPKVVPKLRELHAAGFAIVWISNQAGNSSAQTKFRNKMPLMCRALDVPVRVFAAWGHDEYRKSSTGMWDVFVDRFNGGVPIDYEQSFYVGDAAGRLGDHNDTDRKLAINCGLPFFTPEEFFLGRSATGYTLKGWDPASHDHQAPLFTPTSTPLLPRRNSEFDDDHPPEVVIFVGFPGSGKTSFFKNHFAPKGYVHVNQDTLHSRPACINLMKSCLSASPPKSCVIDNTSPSRGVRAEYLSLIRTSFPGVRVRCFYFTAPIQLAMHNSVYRALCEPVDKGNGKVREVLPMVAFLSFRTNLEIPTVDEGFDEVKRINFNFEGTPEQLKKWQRWLSDIYPLKSLTPKSASSGKAKSSSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZI6</accession>
    <name>A0A2S5AZI6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_7076</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZI6"/>
    <dbReference type="STRING" id="741276.A0A2S5AZI6"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY69944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="122" mass="13528" checksum="2C5A548283B6631D" modified="2018-07-18" version="1">MAIPPVSQDLPPAGGFAPIKYKRNLPTKGPGGALIFGTVAAICTFGFWRVGQGNLEKRQRERAWSRIHLVPLLLAESDRDVYRREQAALAREKEIMKDVPGWEAGAKAYHSKRYTPATVVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZK7</accession>
    <name>A0A2S5AZK7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_7008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZK7"/>
    <dbReference type="STRING" id="741276.A0A2S5AZK7"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="9">
        <location>
            <begin position="431"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY69964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="535" mass="55526" checksum="3E6A00CC8CB72262" modified="2018-07-18" version="1">MPPSGGAPLAQLTPQQLAALQDHIRQTRATTGQEVTPALIQAWMQSNGIATGGAGGGGGQPQPQQPQQQVQQQVQQQAPSLDQILNHLYPPHLSGNPPAALAHLQNVLFPANQGHKQSPLLQQVMLLAQNGRLSPEQMGMLKQAVALKNGAAQGQAQAQQQQQQQQYQQQQQQQQQQQAMPQQQRAAAPSGSGGTTANEQNATQAVQQLRNRRQAMERRAREIQAAQQAQIQAAAAQAQGAGGGAAASLQQQQQQQYRTASPASYPAQLLPPGSQPGALRQSPAMAGGNLPALQPGMPAGPAGGKPTNFVPGLAAGAGMSIPGTLSVQPPTAEPFPAPRPTLSGGLANNPSISTPAITRPPTAGTDGVFGSAAGGGSGAGATGAGGAMASGSGAPEMAGPGGANGGANGKSDAIPSKEIRPDDSKGRTVNKRKIRELVEAVDPQERLTDEVEDLLLEICDEFIDSVTRFGCQLAKHRKSDRLEVKDLALHLERSYNIRVPGFSGDEARQLGARRVTVPPGHAARLAAIRDGGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B047</accession>
    <name>A0A2S5B047_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B047"/>
    <dbReference type="OrthoDB" id="2529383at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="500" mass="55628" checksum="F809D97D20D95381" modified="2018-07-18" version="1">MNGDRVGYHWPALAQQAFMAGTCRAGQSISEWCALSAGDRCCEALCPNAPITGPGTVIVFTVGTLMNVLVALLWKSEAPFNLLLQLLSTDGAFAGLLFRLLLTENRMTELHAAFVPLAIMSCFPVAFAACTVEIEFMHNLDYNSYLRLRHEHVDVNHETAQNQAEPGEKKRNEGHYDEEQRTKLEKGIKESRIFGGFVPRTYLPWLVLSFYGIHLIGWAFLILMSLTVGDNDPFQANCGPELPVALWSRVVGIVAIGFWVAMVLLWFLFLASMKRWRSEAGKPRVKLDVLQILARLTHSHSLAEKVHPVIEGWSASREYVRWSAVMVVYFAWAAAYIAMYILVLQKLVMVGDNPFDYGQSVLGGAITVLRCIVNEPSYYRSRDGTVKRLGFLKTGVNSVKHDKNMLNEATRRGIETDDEQPPEDAGDEEEAVPSGRLSRSHFVGHRPTSIHDSLNRPPSSDAVGIRFEHAGPGSKPLSPVLPTLHAVPQRRGTVPRRAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0C6</accession>
    <name>A0A2S5B0C6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0C6"/>
    <dbReference type="STRING" id="741276.A0A2S5B0C6"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051373">
        <property type="entry name" value="Lin-28_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109">
        <property type="entry name" value="PROTEIN LIN-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109:SF1">
        <property type="entry name" value="PROTEIN LIN-28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="4">
        <location>
            <begin position="126"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="362" mass="38350" checksum="842267EB27A7FDFF" modified="2018-07-18" version="1">MKQDVGGGQSRGASQGGRAATRTSPDIAGRSKRGLADLPLDTSPLSSFVALEDALPSIKTSIPTGLTSALAEYSPTEASPTTEGAQQEAGPNRFLRRFLHRHVHDGEVSEGEEDERSDKDAAKMPRRRGVCKFFNAQKGFGFVLDDYADELGGVEVFVHYTAITSVKGGPNGFKSLAEGENVEYSIAPGPKGWQAQNVTGPNDGGPGAAAAAVLTEGNPNQLHDPYRPVLIQAYTYHGHAASPLMHYTTTSVPGGVPDGAVYEPFPYVHYGETRPSQAPPTLAFYPPVGPMYPHAISPPSIHVHGPAYPPYHPEPFVPASPIYQSFSPTSPNDSYQSGFPGPASAEPVYPISHHTSHPAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0M1</accession>
    <name>A0A2S5B0M1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0M1"/>
    <dbReference type="STRING" id="741276.A0A2S5B0M1"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="175" mass="18797" checksum="4BA3A8A978052F2B" modified="2018-07-18" version="1">MLPTAPSKDDGRAHVFSFVQVRGSLPAFWTESASLDGGPAVALSPDVVRKSLPAFSQHIDELARVYGGPIHALAFLHEGKGGVLSAEATLLQAFKALTAEARHHSAAGILTLDSLDITAKNLETLPRGIHAMLRPYMQQMQFSEVSGTVDDGSASLENEQCGVFRVNCREYVSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0N7</accession>
    <name>A0A2S5B0N7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0N7"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="403" mass="44603" checksum="884AD6AAA40CD019" modified="2018-07-18" version="1">MEDEIAELADSAQAARREAQALANRTARAEADVETLGKQYDTTLGHIKKTHEAALAAQGKIDKEKLKREQAASEKAIKRLDQVARGALEGKEAAVRRMRALQFQLEQAKLKARAPLANKNNNTLARKPAFAPSKLGDLDLFAEAKYALHSGPHFSASPENVTDHCNFRSAYFPRATEQLKQAELELKGWKPVATVHELTAAAVVLDRYFLLLDIFNLGEIDVQNLLLGAEDFARLVVERRSPSLADLLQTLRRPSESLLLASETELKGQALDFRRKWKKALRDLSWEVKLHKADVKKLERCEATIEAMAQEKGHLWARCLRAESERARLETVVGGLEAAVEAVSASSTVATAIASLERAVNSMSRLRDAQVDVRRECSFLREEAAFEGLRALFGGECESGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0U6</accession>
    <name>A0A2S5B0U6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0U6"/>
    <dbReference type="STRING" id="741276.A0A2S5B0U6"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="195" mass="22494" checksum="801DEAC739E26C0F" modified="2018-07-18" version="1">MSNLRSQKRLAASVFGVGKRKIYLDPAHISEIGNANSRQNIRRLKKDGYIIVKPQVVHSRVRAREHEAAKAKGRHTGTGKRKGSAEARMPTKVLWMRRQRVLRRLLRKYREAGKINRHLYHELYMKAKGNVFKNKRVLMEHIHKAKAEQNRTKLLADQAEARRVKNKAARERRAERVAEKRAGITAVADEAPAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B156</accession>
    <name>A0A2S5B156_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Exoribonuclease H</fullName>
            <ecNumber evidence="11">3.1.13.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6432</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.2" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B156"/>
    <dbReference type="STRING" id="741276.A0A2S5B156"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004533">
        <property type="term" value="F:exoribonuclease H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="648" mass="67380" checksum="FDAD2359CF039268" modified="2018-07-18" version="1">MGRTASPKKPSVSNRSLSSRLGVVSAPSPLRFGSSHSASPATSSTGTPVPSIAFDMPAQKRAFDVAVGPATPGGAGVGSTSSSNRSRPDKRSRRQKRKATQPPADTGKESAATATATGDADLEEGEVVEGDFSDLFMVDTTPAAVKPKDRFVPTETLNAATPSKKTTGEPEELVSKPLAAAVEGKELPLAETSMPGAADDAESALDSDDAMRIFAREVAMTDDSDNAEDENDDSDSDEEDEDEPAEEDDFGAAVGQGLMLYDDEEQLQQAIQGRIVDDSAAPTTGRYYKEADLTKTCVLCGEHGHSSRDCTHSQCFICGAIDADHEARNCPVALVCSACGSRGHFARDCPIAPGGSRGSYGQRCNRCGSSNHGAPNCPKLWRIYDTSGPKPPKRKIVLACANCGSGKDHFIDDCMMPRGHPMKHADASAFNRDALGAAGASLPLPSAGPSSSSRRRGGATGKLDMRPRSNTAYEDDAGDDDWFASRNRSNGGGNGGGGGGRDRSRNGGGGRGQQPPPPPAFSGGSRGTHIHFSDSSRNRFEPGPGAHSGSAGRSRRGDYHDQDRDYGASGGRAGGRAGGGGYDSPRDDWRSMYGSERDDRRGGGGGGGGGSGRGTPSLLDRMGTSRSQTPTQHGGGSRRGPSYRGGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1K7</accession>
    <name>A0A2S5B1K7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000107">
        <property type="protein sequence ID" value="POY70674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1K7"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="932"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="957"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1088"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1127"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1164"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1205" mass="130478" checksum="6FC3EDC1F8504979" modified="2018-07-18" version="1">MDSDIWDDDGWQDMPVIRSSDLDTPVSMFDADVRSERDSKNRLRVTAPAPTRVADPSGATGGYGAMAGGAATGNATGKLVEPNEKGGAATGLREKEELDEMDYTRLELDDDPEEDEISMRTQYLFNEDTSMTPLSQMQQTKTLLTEGQRIAYVGLCKLVTREMVQTLAIAAKGAKELEPARESCQHWANKIMGRLYRHMDLAEHGVTSEDLVPSLVATYTMDNPEYDPEAAEEAAQEADIAVVPDVASPRRSSDFSGLPDDPPRPSPTKRRRTPSPPPELQIPQSVNDDVVDSLGDLALGQDEERREEEEAERLPGYVRNEVREIERRASQAALRSPSPTSPAKSRTSRAHSLQPVDPDAFDNGGDIGAALDDPPTPTAGTSELPRSPRRSQEDGKRRSIESAAPDSDDSRSSTPEPSTPKASSIRLPAYDVEDPLEEASAVTDDLSSAVLPSTLPGVTKKVTSLDRTVTLDIRWTVLCDLFLALIADSVYDARSRVLLGRLAEKLGLEWMDVVRFERRLTEALEIQEAVKQKAHTEVLEGRRLKDRQKRYLMMGLATVGGGLVIGLSAGLLAPVIGAGLGAALTTVGIGGTSTFLSGAGGIALISTGATLSGASIGGKAMARRTRDVKTFDVQPLHNNKRVNFFLTIPGFMAGPHDDVRLPFSTIDPVVGDVLSILWEPEMMGDTGNALKILTSEVLSSAGQQVLAATLMATLMSALQWPIMLTKLSYLIDNPWSNALDRARQAGAVLADILLNRRLGVRPVSLIGYSLGARVVFFALLELAKQNAFGVVQEVYLFGATVTASIKVWRQVRGVVAGRFVNGFAMNDWILGYLFRATTGGLQTVAGLRPIEHVPDLENVDITHILDGHMSYRTKMPKLLAHVGFKVTADHFDEPDFDPQAPDREVLTEEEIERRRVEKEKRERGALGIFRRKKKDLAEPSSQPLSRTASTEEYDQPARLSSTSGASSLNSSRNASRLSISSIPSTDGSSERRSADLVMPGDGTLTSRDQVHEKADIPAASPREAPVPSGFDLDKLRQEVAQLPRPSPPRAASVPPIETPEPSVLASTHYGDNEDLQRPPSAPPPLEPPRTDLRELDQGLDPRELLRRQWNGDTVPPSTSEAPALGMSSSSAWDSSANLPDDQYASGFSFPSPGSPPLSDVPTFTFGNGTLSSTVSTKRQAAADPSDVWASEDTSSPADLGSHNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2A0</accession>
    <name>A0A2S5B2A0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2A0"/>
    <dbReference type="STRING" id="741276.A0A2S5B2A0"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="398" mass="42025" checksum="F348E77A4537B801" modified="2018-07-18" version="1">MSEGNAHVTEETVASSAETFGRLNQHPEPSAPAAWRIGVSADPNTQCRRVDEDAHAFIYDFAGLRGQGYFAVFDGHAGKKAAEYCGLHFHEHLLDNMRKDPSTPIPHLLNATFHSVDTQLSALSAAEGSHSGCTAVTCLLRLEDENGDPVGEGSGVAPHIIGGEKGKLDGKPGEACEAAEAVGIDPTEGKPGSGEGQHPGGSPHDGSVKSKIKNMLSSSGSKISSLGSNSTSSSPTDNSPVSGPAEEVKAAKRTLYTANAGDARAVLCRGGRAIRLSYDHKAGDAKEMQRIEAAGGYIANQRVNGYLAVTRSLGDSQMKQFVVGSPYTTETTLRDDDDFLILACDGLWDVCTDQQAVDAVRDIRDPQQASDKLVEFALSNHSTDNLTVLVVNLRNNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2C9</accession>
    <name>A0A2S5B2C9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7727 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2C9"/>
    <dbReference type="OrthoDB" id="2110422at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629:SF1">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="136" mass="15538" checksum="6B3DE99DB5974FCF" modified="2018-07-18" version="1">MGALIWYEWARLLALTSGAYVAWAAMWGFFYRKYFWDFVGGSLGPHGIEPPSGAAVFVKLIVDLPVFQIVNLVNGLLTLALEWPLPHIKRYKLYGSHLLRIVLYFWSALVAAFVYQTVMGTIFYLVAVLAYARSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Q0</accession>
    <name>A0A2S5B2Q0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Q0"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Q0"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14280">
        <property type="entry name" value="UBA1_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000254">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="369"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="415" mass="42641" checksum="D8F882DF5E35FF29" modified="2018-07-18" version="1">MVKITFKTLQQKQFFIEAEPTETVADLKKKIQADQGFSVESQKIIFSGKILPDDKTVADANFKEKDFCVVMVSKPKAQPAAAAAAASTSAVPAAAAAPATTAAPPQTPAQPTSAAAPSAPNAPAPAPAAAAPAATEPETPAPANESQSGGDSATSFISGSALETSINEMVNMGFPREQVQRAMRASFNNPHRAVEYLMTGIPDAPAEPAPTPAAANPPGTPSPAAAAPAASLAATPAPAAAPAPAAQTGAPRNLFEAAAAAASQPQGAAAGGDAAASTGELAALRNTPIFSQLRTLVQQNPALLQPFLQQLGASNPELLSLIERNQSEFVQFLQEGAAEGEGLDALMDQFGDDEDGVAPDGSQYIQVTPEENEAIERLTGMGFDRNLVIQAYLACDKNEELAANYLLEHGFDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Y2</accession>
    <name>A0A2S5B2Y2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Y2"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Y2"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="115" mass="12850" checksum="ADDA687E9AB09392" modified="2018-07-18" version="1">MSSSLAPSCNAPKHHYDTCFNHWLKSYLLLIAPPLSNPSDTPAGVKERDKRNKQIAEHKRTLENDCGQAYKDYQACLKGAIQKMEDLPELLANARREEPLEGWGGIKVASEGDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B354</accession>
    <name>A0A2S5B354_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B354"/>
    <dbReference type="STRING" id="741276.A0A2S5B354"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="348" mass="36690" checksum="B6B70A83DBA8078B" modified="2018-07-18" version="1">MNSRKAARAVPATMGRFLKSGSMLKQPPPSFYPLLAHPPPPSLVRSFPSRPESDSKPRAASGAHSAGAGDLYQQAKRKLDNGVALSAQERHAIENPPAHSGQTRRKPPRPQGSRNPRPREIVFPEDEVRRLFFLDHPFEAYRAVSLVEGEKVRAVHGPTGADWTELSQRSTVPTAEDCIAYITNLTEAHGLPLASAYPHGIAQFRTLRAEHETATRSARLEAQAFGATFFGEVERAVQVEERVLDEWVDARAIQDEFAAANAAGGAGAAAAAASSSASAASANAQAQALAQLGGVTWVAPPARTAASSLAASNADDADGSFTGGLRYVEQFAAGGAVQQSDVLVGAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3I2</accession>
    <name>A0A2S5B3I2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3I2"/>
    <dbReference type="STRING" id="741276.A0A2S5B3I2"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018506">
        <property type="term" value="F:maleylacetate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08177">
        <property type="entry name" value="MAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034786">
        <property type="entry name" value="MAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF102">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="4">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="174"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="362" mass="37982" checksum="78B18F89B71D59F7" modified="2018-07-18" version="1">MKPFTYNALPARVVFGWGTSAQVKDELQRLGCSRALVLTTPQQSEAGEKIKAILGDLAVGIYSNATMHTPINVTQEALARAKELNVDCCVSVGGGSTIGLGKALALHSADGDAKIKNIVIPTTYAGSEATPIIGQTENDKDGKPLKTTQKTLKVLPEVILYDIDLTLSLPPKMTVTSGLNAIAHAVEALWAVEANPITSSLAVQGIEAIGRSIPLISKDPSSRDGRSDALFGAWACGTCLGAVGMALHHKLCHTLGGSFGMPHAETHTVILPHAVAYNAPFAEVAVATVARALGVDNAAQGLFDLAKDNGAPYSLKELGFKEEDLERAADIAAKAPYPNPAPLEKAKILQLLTNAFHGTRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3M5</accession>
    <name>A0A2S5B3M5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3M5"/>
    <dbReference type="OrthoDB" id="3358860at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="264" mass="29213" checksum="519660F787AF18CA" modified="2018-07-18" version="1">MLAGAIAALFTGYYDLVFVPVAVPELLVRAMLPAEWGNADDAFLSADELQQATQVHLPDPGQGKRWVCVEAGKQVDTGVNYVPMGKSSFFEAKVEIPFLRHPLVKSTVPFTFKTVMLFSSRLMSFSSNHLTGLRSHHVVCIRTDNSYEAMDWIEIKNEGEVVVPEGQRWTEDLARRVLEGWWVGEHTGQSATKFIATSVEDAKPRSQLRVRLNLPALTSLTPERIKELAGTQAEIEENGWGAFDAAGFDLSESTKMQIASLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3T2</accession>
    <name>A0A2S5B3T2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3T2"/>
    <dbReference type="STRING" id="741276.A0A2S5B3T2"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="61772" checksum="F601F3C441A7CAF5" modified="2018-07-18" version="1">MAPDIVPSSPQGLALQAEIQKKLADFGWSTEDDAVMAEYCIVMLGNRKTPDQIAAELSDLIGSDFDRSFVEWMFDAVKRHYPEPSAASSSSAAPAAASSATSPPTGPSASSASSSSRRDGPNGVPSRPAGPLGGGGAQATGGRQVFGAAMSGMKRSARDGDDAADARSGDGSSGRQLQRARYDGPSGGRPHNQRSLFDRVNGNNPQFAPGRPTGPVNNTGMPQPAFDAITQAVNAILAGAHPSILANIPFAALTAHPFSSRLPPQVMAQAQANAAMQAQAFAAMQNVWNQPPGASAFGAPGGGPVPAPGGGVFNPNAAPFQPGAGGPGGFAGRPPTKPSGPPVVLPTKPTNDAICKHGVDCSKPQCPYAHPSPVATKESGLVLSSDACEKQLKCEDPDCPKAHVSKAQKTHPPASVSSGTTAIAPPRPAPPAESPAAGALAGAGEKPCKFGGACTRQGCVFVHPWDVRGDPSAQVMCRYGAACTRADCHFKHPAHRPAPYSRNKFSATFAKKSGSPASAAAAGGSGKATEGSIAPKPEESAEHVSERLKRFAGSSNAGETERILPGQTAASNGDAKQNGNGGHDDQQKVEIHLDDEEDKKVEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3V1</accession>
    <name>A0A2S5B3V1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3V1"/>
    <dbReference type="STRING" id="741276.A0A2S5B3V1"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="56"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="378" mass="41701" checksum="258505D5907C1991" modified="2018-07-18" version="1">MAYAGFAFKNIDHTARDGVVMSLVQSEKPSVADYPTSSPYASQIAGAKERFLALLASDDGWQELGEKQGVVLTKKNVKSTGILSLSHDKPTERNRRLTGRKYVVSCRWEMRHRRPSTLTNPVPIVRGEAVVENIAPWELLGGVIRAQEIRKQWDPRYDNGVYLRRYSQTEVLFHALTKGTRFVAAPRDIVGIQKDFVEADGTCIVVQTSVDTDLAVELPKTTRANLNLGAWQFKPEGANTRVTYVVQVALNGSIPSMLASAVANETPLCVARARDVYYKHGFAPHLKYHKESETSIVYQFEDYQPDSRKYICVLTTGAHNGDSVEIAYDTRKMYASGGVRVSVEGDQSAVSVSDDGNGTVRVVAQESGKTVTIAVTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B412</accession>
    <name>A0A2S5B412_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BMF94_5437</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000083">
        <property type="protein sequence ID" value="POY71517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B412"/>
    <dbReference type="STRING" id="741276.A0A2S5B412"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="190"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="POY71517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="345" mass="39207" checksum="EAE0F8A9F355D85D" modified="2018-07-18" version="1">MAFTVTVKPRSSKPSKRFPLTLQLDSTEPTVGDLKRAIAAKAKLDVNRQRITTIDKKQALENDDAALIQLGVNDGDQLEIKDLGPQIAWKTVPPTNAPMVSNQFGPLFIHPLFYYGSKLIYRQDFEHSKMQKWVSRPLYKLDELEAVCRDKRQRGLTDSVCHRIALVLILLHYAKRELETLFVHRFSSATMPFFNIFKNSGHYWGLSGVLLAAPLYGPWNGAKALTGSHIETDAWLYGWTALWTFAELSNLKTHLTLASLRPRGTKVRQVPKGYGFNTVSCGNYFFESIAWVAFTGLTLNWAAALFTAVAVGQMYVWAVKKHRRYRKEFGDKYPRGRKAMFPFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B465</accession>
    <name>A0A2S5B465_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B465"/>
    <dbReference type="STRING" id="741276.A0A2S5B465"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000365">
        <property type="entry name" value="Related to CDC24-GTP/GDP exchange factor for Cdc42p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="306"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="504"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="805"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="966"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1096" mass="117309" checksum="E0B155A90426949F" modified="2018-07-18" version="1">MASVHPYAASARMTPSGSLNGSQSNGTAGPSNSQHYPNLSRNGSSANLSASSPMMQSGSAPSTPGGNGYSFQQGALAGGGTRPAFERAASSTFGQVGSVGMSATSSTDSMPVATNSALNKAASASSSIYQRCTALRERLYRVPEFRERFVDDAEQSLAAAAAASAAAAASGITPPSSNGGTPDPAVQTDPVSQVLSVLRLGASLCYLFNQLGHAHQLDVNPQATLSNLKACQRGAAHFIMACKQDLQWPEQDLFAVSELYGQDTNGVVRVVHAVTKLLDVLESQGVLLPPTEDSQAVAPQPGPSDERSLVVREILDSERKYMQDLEVLQDYQRQLQTSDILTQDQIHSLFINLNKLADFQRRFLIGVESNASLPAEQQRFGNLFLQMEDNFACYEPYCANLTNAQDLAIAENAALSKLAHILDPVSELAPLLIKPVQRICKYPLLISQLLKNTPDTAPNYDELKAGLESVMRVTDKVNEEKRRQDNAQAVTDLASRVEDWKGHDLSSFGQLLLHENFVVIKSDNEREYSVYLFERIILCCKEVVAQGKKEKKSNSILKRPPSQRINRLQLKGRIFVNNVTAASPLQSRTGQYLLEVRWRGDVGEEAFTIKCRTEELLRQWQKAITRAVEEAPMRRRHHLSASRRSERGGVHSPASQFPPTPMAEYAPQLPSPHSHSDHPYSSPNHPPGSYGYSNPAQPAFPPGHHAAGQYGFDDEGQDDMHSEMGASESGRATPAGGSGTGARRGPSTRSLPAGDPREHSNSSHAGSLRPRAQTEDASSHVMSQWRTQPPPPTSNPPARGMSTNSSSGDAHSLRSSASSRQLRSAPSAEWGGPGPGSLTSSPAMSYARLPSGSAQQHGYENGDAYAVSRLPTGPSYGSSTGGATMTRQGSSGPYMSAPSSQAPSMYRSRSASSTHAYQPQPNGRYSESPPSHDDPSGAYRKRESDSSHATDRSSTSASQGGHSGRRGAVSSGTSSATSFPSPAHSHPSSVGTAVAANAIRVKVFFGEDTFVVVVLDTATYAELVDKVIGKIRLCGAANSKAETTALRLRYRDEDGDRISITSEEDVAMAFETAKAMASDKGHGAPLELVLYATVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B493</accession>
    <name>A0A2S5B493_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000076">
        <property type="protein sequence ID" value="POY71602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B493"/>
    <dbReference type="STRING" id="741276.A0A2S5B493"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="686" mass="72850" checksum="A6C6910B0B508F1A" modified="2018-07-18" version="1">MSFVSNVFNSTVQDDRTLDQSAPPQSSHEKRHHHGATASSRFHSSYEAGISLPGDQERRAGAVRGDRSFPSSSDDDDDDDERNDLLLLNDDRALPGSVLPAFVTRLTGGAGTRGGRGWRAYESIVPGASRAAAAGTASHVVFEHAPHDDDEFDSEEGEEEPVPGAFVDAAAAAKSTAAAAESQKRPSPAPAPPPQVLHVYPVPGPTEQFESGGGQQIVFYRDAGWIVAYGVSLLAVIALALQAWWTSPPPPPSSSSLPTSSPSRAAGTAVHSLVYATLPNLIALAFVSAVAGLATVLYLSTIRRLLPALLSGAVVAGPALCLTTACLALYGSFGTDGVAVDRGWQVGVRWFAVACCAMAVVCGRGVYARQKELQRAVNVGQLACQTVIDHPSLRLFVFCLSALSVLVSFPFFALITTLLTYAPTSPRTASYGTAWVLLVYLWTLAIGRGLSHAVVGGCVGTWYFERDDQEYVGSVEVTRASIARATGPSLGTVIAASFFVAVFSTLATVLRSLRRVLQSSRLPSFLSPLTSLAPVFAVLAGWAAFFNSYALSYAGMTGEGFWSASRETRELFRANRARNIQDTALLRLTLFITSSTWGLLTGLITFFVTSSHLSPSAGGYTPTLAVLCYAVPMYTLRLCHNLIGDAVDALFVCTHLDAENEVSHCPKAVEAFGTPESNDPYATLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B512</accession>
    <name>A0A2S5B512_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B512"/>
    <dbReference type="STRING" id="741276.A0A2S5B512"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="313" mass="35227" checksum="DA22C70B467F5845" modified="2018-07-18" version="1">MLRSTANRLASGSRARQSFCAVPWLASTAARPFSISTPRTAPPPAGPPPDPKPTAAPQPHITAREAADKALEEKGTTPPKPLSRALGVRDPPRKGKQSREEWRADLLNREKRIEERRHLVKEVGKGYFHDYNALRHEGGKSYLAPKTLIREDLSLYFPDIEGTSLATKEKVHTTDLCQDKISLVVFSSFRSSEEHINSFVRPTLADLDGDSRFQYVYINLQENPLKSFLVSMFLSSLRKTVPASQQPTYLLSHQSLEYLREPMGMENKHVGYVFLVDQHGKIRWAGCSWATVDEEEALRKCAHVLVERLTPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5B2</accession>
    <name>A0A2S5B5B2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="PJQD01000069">
        <property type="protein sequence ID" value="POY71925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5B2"/>
    <dbReference type="STRING" id="741276.A0A2S5B5B2"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="56"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="481" mass="51086" checksum="7A8A78D148C6AB6D" modified="2018-07-18" version="1">MARVNDDVLTMPWIPTPSDGLDASETLRTQYETEQTISSLLTEHLSSAAEPTIASATHVAYCRRLLDHPLPPYFIGLDASRPWVLYWTTHSLALMGKELDEAVQLRLATTLAAFQNPGGGFGGGPGQLSHLAPSYAAVCALAYGGPVGWRAIDRPAMYGFLMSLKQRDGSFIMHHGGEVDVRGCYCALTIATLSNILTPELVEGTAAFVASCQTYEGGLAAAAEIFTDSEDPVRSAPLGEAHGGYAFCAAASYLICTSVAPTVASPRPLGHTHTLDVPALLRWAASMQANPIEGGGFRGRTNKLVDGCYSWWCGGILPLAECLLADETGTGPEADLYDRASLQQYVTLVAQAPSGGLRDKPGKSPDAYHTCYNLSGSSSAQKRPLFSTARRKRLAEAFVEKGVAAMAPAKVDGSGGAPAKADELVRKAYSASLAWESSEGPSSVSLPDKGDSHLVFAHPVFNICMPQVEAMMAFFYGQVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5C9</accession>
    <name>A0A2S5B5C9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5C9"/>
    <dbReference type="STRING" id="741276.A0A2S5B5C9"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="570"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="922"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1222" mass="126677" checksum="43AA38105005002F" modified="2018-07-18" version="1">MSFALNLDLTSGRDMGEATSSGQSTDAPTRPPIASTSSGTGLEPKRSMSSVNRRSATNGARRKGKGRGRQMMHPDDIAVKIFYSLNSPRFSTAGGGGNQHLAPSPSAAKTAAGLSPDFLAVLDPALAPSPEPVPSPASSAPQRSPNSSSQYSCMARLATPVWVQVVGSNRQSAGAASPQFGRVTLKTCLSAICISRPELVIDPTKDYSVSATDPFESMHQQQQATAQARLAAEGHPHQTDSMDPLVEGKGMLSWALAEKKEGTTLVCGRVIGSRDGTAEDARPSKRRRTGPAPGAPASDSEDDDSEAEEPEETLEVYLQLTEREAFTQGQFLHCLRSYHNPISHIQSQLSELDSSPPKRREPPSVTADAAVSAATASLEEPGASSGDPVKPKRPRTSHPASLQPSAMSHTAPFATSASLAASCPAVAPTLPDALGHAGLQDPRTLALLTQLLPTLSGQAPGQAAPIDSSSIDASQAQALLPAIQTLAKYCGVDLIAPTAASSATASTAPPAPATSAASESVLSLSAMPPTTAVRSHQSNDRFVAIDTSDLTDAQRNKIGKQNPRDPKGGCTNCKRRKSTIWHERRDKDGLQSSVCNACGVFFNKNGYHRTKAAAAPSSSAAGPRSAYPGTSPPRASTRNGSGRPLQARLTATCEADLVKRKAKKGKSSPVAGGTSIFATGGLIPPLSPSKRVGPRSPSLSFAAAFGQGSQHHSPQRQKTMSSPGRSPRMRYRNVSNPFAATSPVRGSHASRTHHDGEQADGYDSDGEARGPNPLEYGNLFGMDNGSPSPVRTFKEAPGAANSATTGDLPSYLLTASPGTALDRILNETNIGSISAFDGGASGKRVSPGVPNAATVSDFSFFLQQPGSPTAGKGHSPSANKENDRPLVAATSSTDPAQPATDADSFDPVVSSLRREFNNRLSSNALTAPSSPAPSSPCVLPRTSTATPGSKGKAPQSCGRAAPSIIDGFLDGLVPAYALDDSFEAERHPDKTPASESDSWSPLAAGADPEATIRMGQDQPNPFVTDQDVASAQADRPVRRAAYIPAHLLAPSDATDPFDFGSLPPSSPPMLPSDAFPTPSDFEGVTPSADGGDAQAGPHGQQSMLQAVAQTVASEPNADTRQAMISLLQSLRSGATESSTEPGPAVETGDAKVQLDRDTVNQLLNLISAHGAPESQTSSKSPSNPSAADGTRGLTALNAPGPLVTGDQQMAELYHDLFANPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5N7</accession>
    <name>A0A2S5B5N7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_4955</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000062">
        <property type="protein sequence ID" value="POY72021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5N7"/>
    <dbReference type="STRING" id="741276.A0A2S5B5N7"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0915">Sodium</keyword>
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            <begin position="541"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="POY72021.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
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    <sequence length="1183" mass="131282" checksum="CC16C28584164E5F" modified="2018-07-18" version="1">MSAQSAGGAVLHWLVARAGDYLLRRSEEFEPARGDPTDAAKYAGAGTVEEATHELFSVVTEVNIVHLAITILTLFITVFGMFSGFVKERLYVGEAIVATMFGVAFSGYAAGIFAPRTWDEGHHTDEITLELTRIVIALSVFAVGVELPRAYVLRHWKSLAMLLGPLMFLGWMTAGALMYAIIPGLEFLPALVLAAGVTPTDPILASSVVGKGKYAQEHVPSHIRHVLQAESGCNDGAAFPFLYLALMLLLRGAHSVGQTVGYWILLVLLYQIILGIIIGGLVGVIARKVLKFSKRRELIDRESMVAMYVALSLLVTALTTLAGSDDLLAAFACGTAFAWDDWFTESIEESNFSSTIDLLANSAIFIYIGATMPFASWSMEDLTLNWWRLLLLCLSILAFRRLPAMYALWHWIPDIKTRREAIFAGHFGPMGVGAIFISTLAATKLPTPNLPPETAIDRLALMIVPVTYCIVLTSILAHGLTISFFTLGRQMHSRVQSFSRTLTANSSRSGFGRTFSFGTTTTKKAEQREEPSWMARVKRATRAEDIVINRDDEDEGRSPRRSDESPESLAEKGHASRDDDREYGEEEEEEREEEELEMHAKEEVEAEGKEPTPSEVEAEIDREVDHDDGTTAMFGAPPDDNKVGAGQKEQLVKERHEEKLEKHRNGGSRSRSPSRQRRSSRRGKQREGSYDDAPGDREADVAEAGGSDVEKEVESPDDIRRGEKRAARHRRELEREREREADDHPRRNILGELGEDEDDTPDARKRWREKQMQKEGGGRRQSTRRERTPSPSRKADPRREARYCRGAQTWREGNKIIVDHGNGDVDVIDDESAGRDKRKGPPGKKDGQNVHDVSPEAIETERAALKEEHGPGDHEHNAVKRAAAKMMRQGSAIGGRFLGAGAKEEANLTPEEKERRRKQKLERDAWCRKERKYRDSSPDRPEPKEWLEGDKVVTEYPDGRTTVRPLSEDEKRRKAKKHLAALRSLGHHSDALDAEFARLARSLSNSSVESMEQQPRPKRRDRAPSSRDQPPRRITASPEPMTATAIPEENEEADEYFAPAADHRTGISLSRTDRIEPDSDEEAGDAADAQPEASTSRAPPPARRAPVRQGSSAMQAVRGLFKPKGGNGIAGSRSDSPEPVEADETDRDQNGNPSIRFAAMNRPDRDGPSTGTGRPLPVSTVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5S3</accession>
    <name>A0A2S5B5S3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Preautophagosomal structure membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="10">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="9">
        <location>
            <begin position="331"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="8">
        <location>
            <begin position="426"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="186"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="547" mass="56306" checksum="61156C3A17B78B7F" modified="2018-07-18" version="1">MASPSPAPSQSNPHGNDPLTATVRSLVFNATVPIRVEFHRGDLPATANRTIEFYYLQAPRIAYLALLLADIRTHFVELVLAGAVASANLQDSDLWFETEDGTPLRWHWPIGLLYDLHHLASESALWPARPVTIPSSLASVFAPLTGPDAASRSAAGLSGGPDLSLSVGGSSDARGGRQPRMGGSVGSLRAPAASASGGATPRQRTPSSSTTRTSRSAATASAAAATAPAMNRAASASSPSALSSSFRHSSSTFAAPPSTALDPLSGHATSTAAATKAAGKVGPAVQPWRIVVRYRCASGAGPATAAAGGGADTGGGGGGGGVLLSGGHKVDEIRTGFMAMIKEADYVRWGSTKRVMNLRQEQQDSLWEAVVHNDFERYWQVAAKLVPLPAPFTTGASLTTTASTRSSTPSQALGEGKGPDANGAKHVPIRVYLPEGGGVVQEMVAPLRPDGSPTTLRQALSQLVPLLFPSAPRAPSSSSSSSTLSASSRDPPSAQQQQALPLAYPLVHGVYPPFETEVGWLGACMAGADGWVSVVLALDTRDPPLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5X7</accession>
    <name>A0A2S5B5X7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5X7"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="131" mass="14785" checksum="B6BC7E022283D994" modified="2018-07-18" version="1">MMFAMPSLHYSLPIAGLILVVAYLAWHYRSLYVDRLPPVLSSRLRYYAPLRTFEDAAEQGFSTANFDLSHNMAGDQRAGLDDRALTAIRRIMERENVAFDEARLIHLNAVFRKNGVDANGFPIDPKAVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B636</accession>
    <name>A0A2S5B636_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B636"/>
    <dbReference type="STRING" id="741276.A0A2S5B636"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="38"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="156" mass="17397" checksum="D687486E44C385CF" modified="2018-07-18" version="1">MSRVTDRNKPDDEDAAQLKLGPRGHSGWITDASEMRCTDFSDPDTVVNMLTLAEVKLLLSQIEDSGRAPDNPVFTKTKDYVSTFSRFEGAEMAAAARTTVPQGDGEFEYFEQVQLINLCPMEAEEAKALIPSIKMDDDKLQEHLNTLTLQRKSQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6D0</accession>
    <name>A0A2S5B6D0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">BMF94_4608</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6D0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6D0"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023514364" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023514363" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="536"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="169"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="535"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY72306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="567" mass="62484" checksum="2B93D2200436E84A" modified="2018-07-18" version="1">MPSAPRMPRWMPALRTRRGAPNRQYHAGDAVQSSAVNSTLPPRLRKRDILLRGPQLLLRGPGLLLQAPKVVWKAPAAARAGTRRLLSNTTLRSRQQNPQQRPQGIEELSQPRAETLKSAGEASRAEDAEQARQSFAARLRRKWKETPTKWSPIPVSLGAAVLVVLTLYKQASDKGKEPVPDGGVQVQGPWQVHVIGALPLRSISRLYGLVNSYELPVWFRVPGYKLYSWVFGVNLDECEPSDLREYRSMSEFFMRRLKPGVRPIDDAPLVSPADGRVINFGVIEGGRIQSIKGATYSLEALLQGAGKADLVEGPHGLEPHPHNAEAIEVDEKDFANVNGISYSLDKLMGGRPNEHSAGTSTPKDASLSMAEQKLQRDGPKRTLSGEVAVATEIAKSAFEPREGNKLYFAVIYLAPGDYHRFHSPTSWVVERRRHFAGELFSVSPWMVGKLADLFVLNERVAMLGRWRYGFFSMIPVGATNVGSIRVNFDSSLRTNSPLRPVTPGTFSEATYAGASQMLGGQPLRSGDEVGGFWLGSTIVLVFEAPKFRFDIQNGQKLKVGQALGQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6E2</accession>
    <name>A0A2S5B6E2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6E2"/>
    <dbReference type="STRING" id="741276.A0A2S5B6E2"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="6"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="386" mass="40058" checksum="3FF4E4ECDFF428E8" modified="2018-07-18" version="1">MADLQDDFAAYTTIGERVAVPQDERKPVQAKSAGPAFTLPPALEPFILLSKSARGAGAAGLVEKATAAPGVYVFAELLNQPSIKDLANQEQHQRSYRLLELFAYGTWTDYDGARDQFPKLTLEHETKLKHLTVLSLATESRVIPYSTLLSTLSLDSVPQLEDLLIELFYANALTGRLDQKHSRLEVVTSLGRDVRRTTTNGADDSATISGGDAMQVDSRAATATTSGGGTTSRRAPSLASLHATLSSWQATLLNLIHSLEDHLGAIHAETVNGAQVKYEHEQRVREVAAQVANKGEGGKGGKGKGSSAMTAAGGGGGGGWKATSGAGAGGGGDDDEDDQDGPMDIDPAAYSAMAGGGLPVPPASPGQGGGGGGGSHSGRTRKRGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6I4</accession>
    <name>A0A2S5B6I4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6I4"/>
    <dbReference type="STRING" id="741276.A0A2S5B6I4"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="201" mass="20683" checksum="810913E243225C86" modified="2018-07-18" version="1">MSSSSSATARPTKTKSKSPWIKTDTGNLVSRSCTITGTQNIVLGGKSILQPGGVLRGDLRRAGAAGPGGKETGTVTLAMGKYCNIGEGVVLRPPYKTYKGVFSYYPMKIGDLVTIGAGSVVEAATIGTGVEIGKNCIIGSLAILKDFCKVADGAVVGPGTVVPSLTEWSGSPAILTGQLPESTPEAVEAKAKAFYLNFRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6P2</accession>
    <name>A0A2S5B6P2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6P2"/>
    <dbReference type="OrthoDB" id="2533178at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="175" mass="19308" checksum="CABDFE511DAEBC68" modified="2018-07-18" version="1">MATAVAIPMPTSPRDDRHMPVLSTLDPSFSPSSLHLRPYTNPKRSPSMQPSPVMRASPTSSFSSTRSHDQDLSFSPSSPPRGAIGVPMGSRHERVPYDGPGMAVYVRQPTRAQLRENNGLFGSASRPYYYRDPEEKPFIDIDGKECGARWIYVDPKAQSEHGQPSRASKTACCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Y3</accession>
    <name>A0A2S5B6Y3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DML1/Misato tubulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Y3"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Y3"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57553" checksum="E74CD4934696A916" modified="2018-07-18" version="1">MECCLITRSPNAGPDGNPTTQDLTLDISLARDGKRSRETIQTLPASEWSTLSTSQLNSAQTPDIGRSDPTFKQHALAGWSALGSGESDEFATFAQGRTAWEDSAEGFLLTASLSTGFSGLTTAFVEHVRDEFPKTILWTTGMLENARGWKRTDTERAKAQRMLNEALALITLEDLSTMVLPIQPVRPWSMPDGAKEGELRILPGQEWRKYVRDDVDPATAYETLRTIHLQSAGTELREVDALSTITEQLNWRGGNKVASLSGMTPILPRSYWSPSDTDVARELKRATKDYSAYEDEESAEEERRRTGRKRRDDEVPYGQYGLVRGFDFEDSQAMGPLLEQSALPLRDPISRWVSLPDPYPLDPSRTAPIFRGLHPATGHPLVLPSAPSLPLISSAAQPANAALFGLADPRYPTAMSFVAQQPRSIPTLTTLSTTPRARDWFKHLSRGIGELRRVRAGVLGEYEVALGGREGIDECRERLDALWDEYGGGTADEEDEAAAQAAKDEDENWDGTEQQEDWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B710</accession>
    <name>A0A2S5B710_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B710"/>
    <dbReference type="STRING" id="741276.A0A2S5B710"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="120"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="295" mass="31498" checksum="B2F985D18B62CB77" modified="2018-07-18" version="1">MSITVVNSVAQLNSLTTNPAAVSVIDFHAVWCGPCKAIAPVYQKLAGQYAGRVQFLKVDVDQVPDVAQKFNVKAMPTFAVLRGSAKVDEMAGANPAGLSALIAKHAPAAGAGASASGSGSQDKGLEGFVSLNSEIDQSQVHCLNESAEHPLKDMLRGGDDKWLESDADEQLLLHIPIQQSIKLRALRFTTNSSHAKHAPRTIKVYVNNPGVDFDAAEGGGAEAAQEIVLDEEQARGKKVVELRFVRFQNVKHLSIFVADNQSGGDEDVTRIDSLELVGLAVEGTNMSDLKKLEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7D1</accession>
    <name>A0A2S5B7D1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Magnesium-dependent phosphatase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7D1"/>
    <dbReference type="STRING" id="741276.A0A2S5B7D1"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22796" checksum="EBA5D9E9E50220AC" modified="2018-07-18" version="1">MTKAGPTKLAGDLPQMVVFDLDYTLWDAWCDTHVTPPLLRRNDDLNKVYDRHGQPLSFYRDVPEVLLNLHHSEVHVAAASRTHAPKVARQILSELLLPGSLRDSGRGDLLKARSSGGKETISAIQLFDSMEIYPGSKLSHFRELNKQTGIPFEQMVFFDDEARNREVAKLGVTFVLVGPEGVTRKLFESGLAAWRDGLSNRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7I2</accession>
    <name>A0A2S5B7I2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase</fullName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4547</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7I2"/>
    <dbReference type="STRING" id="741276.A0A2S5B7I2"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="9">
        <location>
            <begin position="161"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="10">
        <location>
            <begin position="373"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="568" mass="61065" checksum="3090679E3E7D8972" modified="2018-07-18" version="1">MAQGYARISGKPGVVVVTSGPGSTNMLTPLQDALSDGTPLVVLCGQVATHVTGTDAFQEADIISLSRACTKWNAAVTDVHDLPRLLEKAFDIAISGRPGPVLLSLPIDVNMSAVQQAVPGWRPALPMGRQLPALSPKRGGPVAATASVARDTLDRLVDTSISRAAELIANAKRPVIYAGQGILATPEGPELLRQLSEKGSIPVTTTMQGLGAFDELDEERSLHMLGMHGSAYANLAMQSADVIIALGARFDDRITGNPKHFAPAARAASSAGKGGIVHFEISPRNINKTIRSDVAVRGCVVNSLRSLLPLLPEASASRRDWLQQIRHWKAQYPFVYEASDPERGERVKPQEVIEALDAWCEGYGKDNVIVTTGVGQHQMWACQHYRWRHPRTIVSSGGFGTMGFGLPAAIGAELAAPRKLVVDLDGDGSFAMSAMEILTAVQNKIGVKIIVFNNGHHGMVLKWQELNPGASELYYPALQPYGVMLNPEFSLFARSLGAHAITCDRSTDLPTKMAEFMEYDPSKVVMLEARVSANEGAFPQVLPGKALHEMRMHPKHPPLVEPVPGFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B871</accession>
    <name>A0A2S5B871_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B871"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="342" mass="38717" checksum="1B46C1103FDD2781" modified="2018-07-18" version="1">MIKQAAFIGLPPERDTALLTEYIRTVFWLTEKASGMIYLALLSRDKLEAALTAVKAICASLKGVTTVSQKTACLKRMRSSLDYTRPLHSLSSNALTMIYERERSRMPLWVAIQRVHQACERFGSRDPDYARVLAASREFGAWVAGFCYTDWTMEYQDQVAAFIEGECIPTIRNKTCQQQLQALTAMRTNAELKTLLELGHEHYDSQEIAASRKEFEKINDRLLASLDKKTAKAFRAWLKHHTAIETAWTRDDRNAVTRALVALHYKLDFNKDKAARLLGEATKTGPLRDALKVANGCFGHNADLQTPREEYRTKGYTARSVGRIALSRRQALVYQKTHAGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B888</accession>
    <name>A0A2S5B888_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B888"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="308" mass="35376" checksum="4AB55CD236D7E4D8" modified="2018-07-18" version="1">MQSTTSPREKDGVRLSVWKMWFQILIHKIRWSVTVRHSPRIAEKHPGRPIDDILRIWEESHNNTLSPAFLQTLEPHQLGAIYRQFMSLAVAVFKSSVEWHDEKYLRLSEDVERSLKITELPEVPETPSPERIPNPFPRFEWRQSSLPAKWFPDLLVTLKTVWTFGSGPAAAKPERQHLTATLLEWRENWNLTLGDRTYLARLTPEQSSALDLFVSLTLFNAVKVKIVEEGAARGVEAGFEKAAQYLVSLKLQDVLKEINCPPPLSDHPQHASSSAEHALGSQPRIARRIARTVYGVDPAEWQRRRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8N9</accession>
    <name>A0A2S5B8N9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_3833</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8N9"/>
    <dbReference type="STRING" id="741276.A0A2S5B8N9"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="350"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="355"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="682"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="713"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="582"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="834"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="915"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="963"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="996"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1010" mass="104943" checksum="60C81201921F4627" modified="2018-07-18" version="1">MHPHDIPVHSSAPSSGAVAPALQSYHALQQQQQQIAFSATPFQTGYPNGQQPQPQPQPQPYASGSANGHASVSGSGSPADAMIPQPRAQQSRYALFDLPTPPDYPRQPGGGSSSAGPAAAPAVATSSSARAVPTSMAPTTTATYQPHLSADAEAVNRMIRQAMEMTRNATGPAGLDFSSLDRVYDATMAEYAARANASSSVQPAQAQAHAQAHAQRPDPSQVHLDLIRQRGGAAAASAVPASSAAPSTSAGSTTSAPVANETMDGTLAAQAEPNGGEQAASRPAASDPPAITSGAQRAAAQVTADGASGTTQANAARKEAAGADSGSGGENDAEPAAPEQPDAPEQRVGRGPGSRQRWTPEEDQELVAYVQMDPPMTWDEIGAKLGRRATGCSMRWYKYLRDRLDAGGNLTGLQYPAPEPKKGKKNKRKGKEDAVAEENAAHEPSQHMVVGSSAGQHEDDDASDAAPRAAEQQSERHSSEVAATSRSGSEQADAAAQAAKRKTRSASPSQGAVSKGTRKASAIATGRIVDLPYIAPEQLPPALPPAQDLPGHPFPRAPGTRVHSNAGQHYLLKSALVENPPIPFQKNSVIRGRRTRTPQELEEDMKRELEEQKQKREAERKKRAEERKRAEDEMQANGQDYGLDMAGVPVGGVNLPVNLPMKQRSSGPGARGGTSKGGTTAHRCPAENCSAAFKRTEHLRRHYKAVHRGEKPFPCSVAGCAKYFSRKDNLQQHQAMVHFVRALYHFPDGTTSNDPPEPGQPATITFEAVDISRTPRGQQKLKRARGKQADDIFQAIRDATALAARSTAANAGGNAAQQALNAEAAIAGVAAALGGPSADASTPSQAGEKRMRDGDDGTGDDVAQDDGHLEKRLRFSDFGSMGTDDTSMLDPALQALTADAATVYGFPVEGFDPTPHDLFDSLPPVPSSSTTPGQAASYTTAPVASTLAAASSGNGLEIMVGSSASATRAQELATAGSSKAGPPDARREGEGSTPHSASVSGVQGAGASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Q4</accession>
    <name>A0A2S5B8Q4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Q4"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Q4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="101" mass="10168" checksum="B993059426243470" modified="2018-07-18" version="1">MSASYARLAAEHASSPPFTPFVPRSALQPLAIILLVAAFILTFAFSTLGSTSTRRRTTSSGKSTAQQPTSTVGKELVLGGAASVAGGVGLVLAFCAIGANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B901</accession>
    <name>A0A2S5B901_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B901"/>
    <dbReference type="STRING" id="741276.A0A2S5B901"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="361" mass="38380" checksum="6479B11E08095B38" modified="2018-07-18" version="1">MGNDGGSIPKRSELIRTKQTRARENDADRIRQLWAFCALSKQPLQQPVVSCPLGRLYNKEAVIAYLLNPPTSAESQTPFGSDGQLVAGHIRSLKDVVTLSLTPNPNLDSNDSHDGNGGNGGGGGGGDQTLIGAANERDPPAPFVCPISLREMNGAVKFVYRKPCGCVVADSALREMRKSLERKNAAAARSTQAGAAAPPTAEDVDDDDETLVCPVDGARNKAGVVEEWVTINPKEDELDLMRERFEARKRQEKEDRKAAKKRKNGAGGAVADGDAAGDEPKAKKSKAADAAAAHQKVASAPAIKAGATVSGLSATLAAKLAEQKKQQSPAIASLYTKKTDNEMKDKDGRSNWMTIGSYSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B945</accession>
    <name>A0A2S5B945_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B945"/>
    <dbReference type="OrthoDB" id="2526690at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="543" mass="58519" checksum="2179775BBEC1BD3B" modified="2018-07-18" version="1">MAALAPTYSRQQTDELLALYDPHLFTPRHNRSTLGHGGGGKGPGGKASSIAASALYGPPAPGGSHDSPFGPSKDQHYHRRTASIASSVRSYFAQATRHGGTAGSGLTSRPGSVRSYASKSQQLAPLLCLPSEILLHILDFAFPAEPHSRWTSAERNHLLCNLALVHPVLRAWAQAELFGGAPVHLTTDSAIEKLSTLAGQHGTRGNTLASRISHVKVYGRHDTGDGGKALAKLIHQLSGLEELHLEDLDGLELRQFVLHSPLRKLTVTRCGFRSRFRIVAAARPSHLESLSLTRCTGHHDSFSGFSLPDLVHLTIWNVSLPPPSALATLEGSEAFRLLGHEVAPRLQSAVVDEQHFHYMFPLALSGGGHHPRSRLEHLTIVRLSHLPTVLDQMRYRAPASSLRVKSVRTLRLVPTPSFTPGATSAERAMIHFQALVSPFRALPAGETCPTGLKGIETVRLDWRYGAWLALCPSTAESAKLADFVSRCEDAGIEVVVEAAPNSVPGAPAEDFYGSTMTGGRRQSGLIWSRSPVDSTTLSRTRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B973</accession>
    <name>A0A2S5B973_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B973"/>
    <dbReference type="STRING" id="741276.A0A2S5B973"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="131"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="562" mass="60629" checksum="AF6B528F0CC38BC4" modified="2018-07-18" version="1">MSTMSTEPATKSKRASGWLSSAKQSLKAIGHPSGSSTASPSASSSASTSEVIISRDLSGNGGEDKSGGSKAASILSRTPSARWKGKDRADERTSAEGRATLTSDMPSIAPRKIIGAVEDEWPLYSCRPADYEIGQPVGFGAAAVVHLATFCPKDVTPRPKPLVCAVKIIDVDRMPTEADIRRLRMETQLMALSKHPNVLRVRGEWIDGSKLCIAVRYMSHGSLLDIARYAFPDGFPEDVIATALAQALHGLVYLHQNGWIHRDIKAANLLVDDDGTVLLADFGVSSSMYPDASTATKGDSVKQASLAPRKSFVGTPCWMAPEVVERKAYDSKADIWSFGITALELASGRAPNSLFPPAKALSKTIMDDPPELDREGGKYKYSKAMKSMIDSCLQKDPSPRPTAEKLLEHPFFRTAKKKSFLVTSLLADLPPLQDRQHRRRKMSSQEADSIGSWNFNPTLNSPLRTLSGEDPFASFSVGPSPTGSRFRSPSAADSRRSVRISTSARPREGSRASHTRGVSFDDHSFPPSPTTAGPGIPSLSSSIHLERPEEAAQDVPRDSANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9D1</accession>
    <name>A0A2S5B9D1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
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        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
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                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
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            <dbReference type="PubMed" id="29375494"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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    <sequence length="105" mass="12087" checksum="395D79FAB340615B" modified="2018-07-18" version="1">MLGPLVKAQLVAFLTKKLLESPTFVGGVQALHGSVTRLQQGAYDTLLQATEEHDRKNPTRHLRDEATETSHRPRADETPREQNKELLAFIERTKRELEKEQQTRR</sequence>
</entry>
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    <accession>A0A2S5B9W3</accession>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
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            <dbReference type="PubMed" id="29375494"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD1149</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1224" mass="127468" checksum="85B58317F8117106" modified="2018-07-18" version="1">MSTTQFGGPGSAFAFAAPTRPARRTNSSSSFKDGVGAAPTATSPGSNGPAPVQPPTQPSLGSFAPLSEREGAAMPNGNHAVNDGGSPGSGPATAPGRSFSSILSPSLTATTNGGPLGDAQGVNGRGKPFVYTRDFLLSLYDEDKARKRPLELAVHDTATRDLYGADSPKPWLLKEYRDGEKELFATSIHPANTRPSRMSRNDSTLSANGGAGATLDLSSLGTLPRDRDRALGSPSLRSPSIDKDGILGAAARDRRTRERSLGGTMGIVGGVLGGIANGAPTSRRRDESVGSTASKDGVPWQSSRWRRSAQEGEDDEASPSVTSRRFPGELSRQSSISEAPGKSAAAESWEKAAVPRETGAEQDSATVTDALPSEPEIAASLLGSLALDSEPVDDPLLSRNVSSATASGAATPSNVGPPPGLAPAVPPAEVMWQYRDPSGQVQGPFSAVMMHDWYRQQFFSSDLRVKRSTDADFESLEILIRRVGDSEQPFLAPKPAAVASAFSSAPGTPQPGSAWGSGASTARAQTPLEQLTAAVAQGRFGASGAAAAASSPFYEPFGSAAGSPSVTGQALPQNFGRSPLVQGAIDPWGAPIAGAGNSPWTGLGAGQQQHSQLQQHQQLQSPAQQQPMFAQQPAAGMHSPMDLLRQLAAQQHGLPSPQQAFASQPQQQPQQQQHAPTYDAFGRPAPVPSTNFFNPNQLASPGQQSGAPAAWLGQQLQQNIPQQQQQQQHHQQQRDQFQDVAQPWAAASPAPIAQNTAPASPVKQAQQELEQHATPSEEVTNQQPVAQAAPSPWNDVKVESDERATEPTPAQASKPQQNESKVALPAVKQAQPAADSRSEDQLAAEQAAVPKATSPAPAPWAKEEKKVLKPVAATPSPSLREIQEAEAREAEKRKEIARAQAAQAAAEAAQRQAALDAQEAAESLPSSASWAAGPAQVPATKSSTGPAPWLKPAAAPAPVVKGQKTLKEIQEEEERQKKAAQAAREQQQAAVGLTGSRGYAGATSTAAAAGSPWTTVATKPQVARAPTSAAKPVIPGLPSTAPAGPSRSVSSTSTATKAAVPAAVRPPAPPVPAVRAAVPRSVNVSVSSPATTVYDMENPPPPSAEFLAWTKQALKGLNVPLEEFVQMLLSFPLDASADVLEIISDSVYANSSTLDGRRFANDFATRRRNDVAVRYPSIFAKGAVRTAAVKPSSMASVLATANSQPKQTEWNVKVSTKKKSKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA82</accession>
    <name>A0A2S5BA82_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_3212</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA82"/>
    <dbReference type="STRING" id="741276.A0A2S5BA82"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="16"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY73677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="510" mass="57538" checksum="FB2A97D82A6F19EB" modified="2018-07-18" version="1">MTSQEVFKSRDGAVFTDSQGHPVQEPYAAQRAGQNGPLLLQDFFHIDQLAHFDRERIPERVVHAKGGGAHGVFEVTDDISDLTCSEFLGKVGNKARATARFSTVGGESGSADTARDPRGFSVKIRTEEGNWDHVYNNTPVFFLRDPSRFSTFIHTQKRDPQTHLKSADMFWDYLSQSPEAFHQVMILFGDRGVPDGYRKMHGYSGHTHKLVKADGSFVYAQFHYISNQGTATFTQEESVKIAGENPDYANQDLFEAIERGEHPSWDFCVQTMTPEQAEKFRYNILDLTKIWSHKEFPLRKIGKLTLNENPKNYFAEIEQVAFAPSHLIHGVEPSADPVLQSRLFSYPDTHRYRLGVNYAQLPVNAPLNPPANFQRDGAMAFNNQGFRPNYQSSILPLNYKPAKYDFSKHEKFVGECVNQLTVVTELDFEQPRQLWEKVFDDAQRKRFISNVAGHLSAAKSDEIKQRTLAVFGAVHPDISAGIAKEMGVSNPAPFQPASADQMIAFRANIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAE9</accession>
    <name>A0A2S5BAE9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAE9"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="427" mass="49730" checksum="CE7963FB0302ADDB" modified="2018-07-18" version="1">MQPYTLPKIKLPEYIEPDTASTEARELEERRPNRCSLDSLPLELLRDIVEQVAPRSVFDTQRTLARLVMVNKQLRYLLLAEARKTVWINASKSEDEIELFLKLLSSVAETLIVTNRMPLTERFRIDGFYLDPDWPEDSALMAWDVWKICMRLPRLRRFFFGDYFYMRNIREACCLPSRPFVLHVSKSSDGLSLGDLDELHIKNSSVGMPYLDAAVELAWSRLAFTGRVSWERSEPEELLRSDLIRLPHLRTLRLGVMWCNKWGCRVRWRIPAVSLDLLDRLEAVQVDLGSRDTVAAMELPPCYFETTAPILLDVSLIHRESLEQQAYRIQQFECIQLRTLDPAYASRLYWILVNSARLRALFVARELIERYNEREPTDKATKTLRRLCSKLKAKGAEVILCGPDDDEFILPEFLDYLKTKRKNAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAT3</accession>
    <name>A0A2S5BAT3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAT3"/>
    <dbReference type="STRING" id="741276.A0A2S5BAT3"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="9">
        <location>
            <begin position="79"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="266" mass="28516" checksum="39F507164AB3C0CA" modified="2018-07-18" version="1">MLARTARAVLPSWGRSLATTATSSPTPPPPPPPPTASTSSSTASTPATTPRSSASSTAPTPVWEHHVPLEPTHGYHVATLHLRAYDDSLADLSFFTNFALRSARALGLPTTGAAALPTSTWLRTVPRSPFVHKKSQQNFWRRTHKRAIKVFDGDEQVVQAWLAYLRKEAFPGVGMKAQYFTYREVGWGNSLVSDKEVDELALRGDQAASAQVHALAQELQGELEAEADRAQAAGEPSPSGGAGDAPAAPVPKKQELKEVAPEPEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBK7</accession>
    <name>A0A2S5BBK7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBK7"/>
    <dbReference type="STRING" id="741276.A0A2S5BBK7"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="108" mass="12376" checksum="FF579A53F2B1F317" modified="2018-07-18" version="1">MDAHQRQLSIKTGVVSRLRKELEAYRVEAETTRGEVTKMEEAQADEYEIRQRKRVLAETERMIPDSEQRLAKAVDDLEDAMEAAEDTHAESDEYKKAAEAVKTAPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBU4</accession>
    <name>A0A2S5BBU4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBU4"/>
    <dbReference type="STRING" id="741276.A0A2S5BBU4"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48574" checksum="939C8AE3AF146A43" modified="2018-07-18" version="1">MPKATAQRKGSSMKHDPLAIQLRAGELDDSGVLSAPGKRQKEKRHQQEGSGLDAKVTQKVLAMAREQQDELAAQDLEDVDESELRAELRDGDEDDDGAFSDDDAYEEYEELEIDEGDDALLDSYVPAGHLEPGRSLADLIMEKIERAGDAPASAPTEPVPEPEDSGFNPKVVDVYGKVGQLLSRYKSGPLPKAFKILPTLPMWPQLIMLTNPETWTPHATYAATRIFASNLDPKQSQKYYKEILLEKVREEIGETGKLSVHTYMALKKAMYKPAAFFKGLLFPLCESGTCTLREAAILGSVLTKVSVPVLHSGAALLKLAEMEYTGPNSLFIRVLLDKKYALPYKVVDALVFHFIRFKRDQRQMPVLWHQSFLVFAQRYKADLTPEQKDALLEVLRFQTHYQITPEIRRELQHSVVRGEEEMAAASTMDVEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBW3</accession>
    <name>A0A2S5BBW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBW3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="163" mass="18918" checksum="42591E378C9D7265" modified="2018-07-18" version="1">MCNDFVGKGDTYIRPPKDPLPELGDRDGFKRVGRDFVIYIVRHASLEMHLPTEARNDLPDLPLVLSMPYIYETYTQKIRLDESAKWHSELCHRLLVLQHYSARMRLAMKIRPVDKAELSRTTKDLVRSYEALKVFVQTVPDRALAPAATRQIDMMLMPLSMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBY5</accession>
    <name>A0A2S5BBY5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBY5"/>
    <dbReference type="OrthoDB" id="2527786at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="483" mass="53469" checksum="B7AF378FC4AAC954" modified="2018-07-18" version="1">MSSDQATRVEQTLLALVANLTTDANPWLHIRDATESATFPVMPPSAFQQLYALSALLGFCGILAIISLLWRFKKGVFWVFRVKRDPFMICPHIVISWSLGVVLMSIFFEVYLALVLQYFRRNFNPNFAYWYYSVWFFPFLSGSLAVWALAVSFIAHRQAVTQKPLRRAAIACNIFGPGVPIAHFAVLLGLALPSGRIYRDLVHVHKTFVTALEEHALGWRPGNRLDAADVQWAVPLVVSEVATYARFSRGFARVFVYYGVTAVLLVLAMVTVAGLYFWNIRRSLDQARRASVASAADSMERPIASITEQQRLVRRTLLNLFCAFFLFAVLGLVFSVSAIVAAANPNALTDSAQSAQVLTFLPLFGFAVLGTPCMVLVLLSAKRAAPSPTRSRETRKPSFASVLPAPALDQDLHLDEWASDETAKPDLALTGLGGSDPPSPPRRFGRWFRRPDQSDRVASSVSYTVDVDVVVEEEFVMKPGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBZ3</accession>
    <name>A0A2S5BBZ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BBZ3"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF54">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1953"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="3">
        <location>
            <begin position="713"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1570"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1743"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1814"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1870"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1749"/>
            <end position="1762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2034" mass="212526" checksum="D4F231F2A5EFD17F" modified="2018-07-18" version="1">MAPSPVRSYSELSLAAFVSSSSPPTLVSDLPLDHFQQVLATDDSSEWTAIANSSAAGASSSSPDTRTKGTGLVPSAAPSPPGPFVQGLAPLDPSQVRLSRRYDPTRKADLVRAVSEVPCDPTQFSLDAARAVLSTPELRPHWDKLVDSATGLVQLDPRTAIVKTDYRLGWPASPRDTVTIARTFDTERELIQVATSLPRAADEPAFLRPAPPFVRAHTHLAAWCFQVVPPSLEAASAAGDPASTLAAIAPVTPRESHRLRITVYWQWNLRLGGGGASTLLSSATALPSAISSPSATGSSVSTSAAALLPAATASPSTSATAHTAHLPALISSLVGYLRFSSPGSGPLPLVTGYGAGVEMNRDEWDPIRERRNLDYAVVATSLASSSSLLSFARDDADQEAGLRREGDRAWVCDLNRLERALEISLPAMGIPFAGPVASGTSVGALTDSDAVGSGDGWDVRILVKALGGGGGGGGGGGAGSTAATPVSTPGLVGKELAFPPVGASTGSPATVTKRLPDIGAAAANPEPPYSVSLTTSPVSLAAANPSADSTPSPRLKLRIEHPPLRSQNGLLRVSVTIQRSTAGGKRVRVNGEKVDVRRDDAPGMGGASRSLLEVAARAGAAMVPNAAEGKVRLLEEGDASPAEVVVPRRPSTGTLEEAASVSSAISLSPTVATTSANPRSNSPAPSSAVQIASLLRRSYIYFLSLLQEPPAKWRHVTDSAGVSVTQLLSPDPTLTIYRAEAVFVGVGVWDAFATVVTPGVRRTWDKNVDGVTLIADEENGAGAGELSEVWWERRKGIWPVSARDSVLLRTAYKSPSSVHIFSSSTDNTSLFPSIPSPADGTIRIQTDLYGWSIEALSPTTTQITLLDQSDPKGWSSKSAWTPQALVQAVAGVRDYSLKNGAPPVVTRLSGKVRKTSEEYDPDKAALRVSFAPIPGASGAVVDEFDSMVECEIRCDATTWAAGAAGGVDVVVDPPPSNVSCLLRHRLSAGGGLWLTIEHARSIVAEEGRVSVTVRKGLSTSSAGDRTAATAQTSGSSPTVIVNGARIKVDVEVLDDDKVRELEKRKRVKAAPVPLDQYETLGPRHGQPAATRSAPNAVSLSPSDETGAVGDAAALGQEKGLHALGKAVPPIEGAAVSSGDAAVSASEASSSVPTVVPGSTGSASDDALVKAPKPPLDPPACALEALAWLQTFHAEQGPELTDPAPGWTNVSERGGVVVRKKLLPRISPTISVYRGDKIVQGLTADEIASIVTSPSCRRAWDDRVDSAVLLSSYGHGISTMALTTKPTFPFRGRIFRVATANAAVKVPSASSGASTSTVLFVASASYTPRDEDPFDPAKLNPLSLPMGQVLLEGWILETLDPYTSSVLAIPSTRCTFVSCTDQKGSVPLALNTTLNANLARALSSVEQFGKSRGPLPRIWTPPLRLQIEGPLGDDSSDDNYVWRLETSRPAPSSPHGDAVIADYSVVEASFRAVFKVSSKPEHDGPASTESRSSSLPPANNVRKPSLLDKGAGKSKPPPLLSPPLGAGQTMPKSELPRAPSLNLLSSAPPLLHKAPIMSELSRKSSHNSLRAAAAASASSNDGGAGLAKATATGSKAESSALGDPADHDLLVAEIVVDLKQYPHGYSVTATSQILSTEDEAPLSLDPVASVGADSHVPAGSVLLRCVAHDAPLPSILTASLDAWKRANHLVRILVPTGAITHPLKDPLRSEDSASAGKKPDWYTAFAASEGALVDVAITALPAPQPTVPDRTTRAAKDKVRETPESVPVSKVTGQANKTVVFNREKLVVLTQKEGKTVLARFDDDDAPLTGAKISRVSSRPRRKSIAAEVEPDRPAPGLLPAQLQRPLAQASRLYAPKPVTPLVDDFDFPDPKSPGTISPANEEARSPTGGAGKILPAAARRDTVASTTTTTTGGPLLSLLSGYPLGRLTTNMLASTVDVTETSATGVVAVRRTYTLSFVLVVAIIAFLIGSLLRSLLTPADYIIYRPESAVEHSQVEHALLSALDVNRRWREARRLLELRGLFGWDLMLAAVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC73</accession>
    <name>A0A2S5BC73_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC73"/>
    <dbReference type="OrthoDB" id="2524207at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="290" mass="30312" checksum="99DC8560F53F0E4D" modified="2018-07-18" version="1">MAVAMVPQDATSPTKRATRGPAPPVLRDPSDPRGTLAVQTGFEDQIRQRAMAARAGVNFGHATTPSDPGSLNQRRRPLGFSRTEPTLSFAGTYSNAAPVASWQSGKDILDEVYAHAALTGKRSDELRPMWETGSATESHVSAASGQRQDSGFFAGPAGGRIASAGPQTDDGDGFDLDEAFGTAGTSRFGFLAGATTNEDSQDSARTVTQRMKRAFQEEEEGTGVAGTGPVEDDEEMPATDVEDEGEDDAAPGPISPFASVAAAGPRRVAGLKRGFAKTQSLPPSAFSMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC78</accession>
    <name>A0A2S5BC78_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2562</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC78"/>
    <dbReference type="STRING" id="741276.A0A2S5BC78"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="319"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="507" mass="55073" checksum="17A696A37CCB7D2F" modified="2018-07-18" version="1">MSTAQHHTSSSTHSSSNSNIIGVHFRVGRKIGEGSFGVIFEGHNLLNSQTVAIKFEPRKSDAPQLRDEYRTYKILAGSPGVPQVYYFGQEGLHNVLVIDLLGPSLEDLFDMCGRKFSIKTVCMTAKQMLTRVQTIHEKNLIYRDIKPDNFLIGRPGTKTANVVHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFFYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTPIKELAEGFDEEFAIYLNYVRKLGFEESPDYDFLRELFSKVLKNRGEVDDGVFDWMQLNNGRGWEAGSSTMLSSSGHESRGHRGGRERDRERERERAERHAQRAAAAAAAAAAAQSGSASGAATPTQAAREAKIGRQPSASATPQPGASVAALKGVQAPTPAAQGGKMNRMSSTGHPYASAGAGGSGAFEGEQEHGSGSNGYRTSAGAMQPSAGGAAATGLGGQNGAAGAQEYHDDDHHRGGFSLMKFLTCRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCC1</accession>
    <name>A0A2S5BCC1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PFU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCC1"/>
    <dbReference type="STRING" id="741276.A0A2S5BCC1"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="257"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="6">
        <location>
            <begin position="394"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="490" mass="53558" checksum="050584AD9AD6CAA0" modified="2018-07-18" version="1">MASTSERPPAFRLSAVLSGHTNDVRCVIAETSRPPTKSPRLASASRDGTARLWLQEEKGAAGTQWRESYRWCEEDRAYENAVAFVPPDVEGGRNGYLATAGADSLIQLYPLDPPQSEPAFKLTGHAHNVCALDVSADGSKIASASWDMTARVWEWTGTEEGYACDKVLVDHEAAVWDVLLLQKEPDLLLTAAADNRVRLFDLATAQVRYTFKGHTGPVRALAKLLPEDLDCALFASASNDGTIMIWNYQSGDSITSLGSHDSYIYSLTSLPTVGGGGLASAGEDGIVKLWNEDDGELDQEILVPALSVWSVTALPNGDIACACSDNLIWVFTRDATRCADQATITEYEDKLELHSAREELPADGSPNRRPRASPSAPAINDESALEAGGQEQQVKLWHEHEWQEMGEMVEGPPTGEAAGKNKEQPRMEFDGQEYDFVFSIDVADDTPPLPLPYNRDSDPRSVASTFVQTHALPDSYVERIVDFIHAHTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCD3</accession>
    <name>A0A2S5BCD3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCD3"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="69"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="543" mass="58784" checksum="1695D370E518FCC5" modified="2018-07-18" version="1">MTQSQTPKGSLKKVPSDLEKDGVVTVLPGVLVDEAYAHAEGIDPVFMAKASVINSALEECGMGRFQWELFTSAGFGYFSDNIWLQSIAIIMPYVAIEDHFPGYPKIRMATFAMYCGLVPGALFWGMTADVIGRRLAWNSTLFISAVFGLAAGASPNFYVLCVMLALNGIGTAGNMVLDGAVFLEFIPSTHKYLITLLSAWWAVGQVVASLICWVFIEKYSCDTERVGIDGYRCDRNTNPGWRYSMYTLGAMMLFLWALRMFVLPMQESPKFLVSIGQDEEAVRVIHYIAKRNGRTSTLTVEQLHKAAEGYETSPSEAKEQRTLTNWDLAKRSFSHFNLDHIKGLFATRRLAFSSGLIIAIFGALGLAYPLYNGFLSGFLQAKGAERGDTSVSATYSSYTYQAACGIPGSIAATFLVEWGRGGRKFAGAFFTVGAGAFLFGLTAVRSAASVNALTCMAAFFENAFYGVIYAIAPETFPTPHRGTGDALAGGFQRLCGAFAPILAVYSPAANSPNGPVFSAAAIFIVAGLAMLALPIETRGRTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCJ1</accession>
    <name>A0A2S5BCJ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCJ1"/>
    <dbReference type="STRING" id="741276.A0A2S5BCJ1"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000012">
        <property type="entry name" value="tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="55"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="396" mass="42426" checksum="1C334B0D550B5A43" modified="2018-07-18" version="1">MLRSRFRPPATSPSLASYVTPAALRAFSSKRPLVVLGLESSADDTCAAVVTSERKILSNVVLKQHAIHESFGGIHPLHAQEAHQRNMPVAIDKALREAQVRLEDLDGIAFTRGPGMYGCLSVCAGAAKALAAASGKPLLGVHHMQAHALTPFLTAAPMTSSPAPQFPFLTLLLSGGHTLLLLARSISSFSILATTHDESIGASIDKVARDLQIPWALGAGSPGAALERFAFPDGLPDSSALPSDPTFTQPFARRLAFSYAGLRSALTRILESEPASQMSEPRKRQVARAFSLAAFKQIEDKVVLALAQGEEVRGLVVSGGVASNMVLRERLRSRLDKVGRTDLPLIFPPPSLCTDNAAMIAYVGVSRLERGLVDPLTVMQRSKWPIDECEAEFEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCT8</accession>
    <name>A0A2S5BCT8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCT8"/>
    <dbReference type="STRING" id="741276.A0A2S5BCT8"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="162"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="331" mass="36568" checksum="8AFF7E2D88449E64" modified="2018-07-18" version="1">MLSWLKGSAATGPTVQQLWVFPIKSCRGTRVEESAYTAEGLEYDRQWMIVDAQTHKFLTARTIPKMVLIHPSINRETGKLDVSVPSANDKDERQVFSVPLAHPTTYLDDPESDPSLDHDFQVWGDTQDGFAVGSSELHTALSDFMGRQVLLIRKGTTKRSVADVPGVVHSADLDPVVGFADFYALLIASATSLKELNRRVPDVVEQSPPDLAINRFRANIVVEGLKEPWAEDGWKAVRIGEEPIEIGFRCARCMLPSVDPDTAIRHKQLPDAVMKDRVVQPLSAPKVCFGMLASPVKKEGGVLRVGDPVAVLDTYPRPADGPYLRDEDRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCV8</accession>
    <name>A0A2S5BCV8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCV8"/>
    <dbReference type="STRING" id="741276.A0A2S5BCV8"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="459" mass="51409" checksum="3D514436639FF2BC" modified="2018-07-18" version="1">MVHSTIVQLETALPPLTKEYKAPSFSPLSPPSTSGTSVYPVGPAFHAHARRILNDRSFLEDDRLERERLAQLGQGDVVEDDADADLGGEDEDPDLLEMDPKRWKEQDHYAVLGLQHLRYHANQEQIKKAHRRKVLRHHPDKKANAGGSANDDSFFKCIAKAMETLSNPEKRRQFDSVDPAVSDEFPDKEETTDANFYELWAPVFERAGRFSRRQPAPALGGPETPKADVEAFYDFFYNIDSWRSFEYEDKDAPEGADSRDEKRYQEKKNKAERDRKKKEDNTRRRTMIDTALALDPRIKSFRAAEKAAREAKRKGGVAGGAAVDPKVKDEEERKAKEEAEKAAADQAVKDASDKADREAAKKAKAAAAKNVKKDKKAITNLLTVHNYFTVAGTAPAPATVEGCFSELDLLFSIMEPEDVAAFKADLDKKSNSDEVKMAFVAQAKKFEDKVGAGKFREFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD02</accession>
    <name>A0A2S5BD02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD02"/>
    <dbReference type="OrthoDB" id="2535929at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="624" mass="66593" checksum="A5B796BF31742190" modified="2018-07-18" version="1">MQATPSALGLSLAPPIPSTAGPAPGAAGGGGGGGLGSLPAPLSKAVERKHTADALLQSLAQQSHATATPRPVAEARGTTAAPTSLPGRARVALEQCIDAAEQCQIATHARLSDEERARALFCLGWAKARLAQLVQPDALPAQLELALDSLNQATRLVTWFPSEPPHLAATPSVTRPTDPNRHQASLDRLALVPAWGAELVAELARAQTILALAKAMSIQEQRGSSKVDGGAAAVAGDEDDRQLADLIDLACRRNVQALFTPVDPHSAQMEPAGPSAIGAGQNGGGPNSTIVDGVDEHQIGGNSSLADASTVLGNARLLRDVLSALLPYTTDPSAWKLRLDWATHIADVQFVSASLSANRLVDVASAEATKLQNSHISPRERQEVKRVLEKTARRMAPYEMRQGNVLLWLGRVMLDAVGALYLGRTEEGFQAERRRREQQALAASSGGNGGMTEEDFEEEEDEADASAVPVPENDLVRETRQVLIRAAALFENAYASILRAPASARRRRLELRVLRRLEATYCDLELLDNASSPEVVELRSQRIERAVLINERLIALGDGVSSGSRSARNGRGRGASGLDEDEMDESDREQAAEEADEEDRELAEDDSDDEQERLSRALGRSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD07</accession>
    <name>A0A2S5BD07_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_2416</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD07"/>
    <dbReference type="STRING" id="741276.A0A2S5BD07"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="706"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY74654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1080" mass="116412" checksum="3478A2E9D89E2017" modified="2018-07-18" version="1" fragment="single">RSCLHCSIPTVDCTRPCSSLATLTAAVLRGLSKRRSNSLATDPSNSESIATLDFEEMAQFTTLHSLLERDAVASSAAVFKYDSTPSAPFGASLVDNKDEVPRVFDMQVRPGAGAALVGFVESAAFTSKGTSDGNKPLTVLGSAASLLALVPSLLALPENSRRPALNLHISTQTSSLAVDEEGEPTLTQVPELGAVLAAVQQLHENWTGAVVLSESAEEAAQVGTGLAKAVNQAGYDLVNVFDGLTAGRQLTPLEASAPVAAGKSLESTIESVVPYFSYSGPASPTKVLVLPASVYSAHAKAAVAALASEQVGVLVVRVLQPWNAEALLAAVPKSTKALYVYAEEEGAGPLFDEVLSSVLSAGSSLKVRALPTSTASVPSVPDWAARIAKLAGSDATNTSLKSLLPAQAKLAVFWDLDSTSGQTETVPSSLAHTFAGPNTGVSVKLDTRYDNYRQGGVQRAALLLEQAGRASKDVALSAVVETAAPSLLFVGAPQAVFKAYSPISTTTVDGETRIVVASNWIADEFATKLPYAQRKALVEIANGSSGHVFAIDADKVAKAHGVSAANVAEIVFWTLYLPATISAKELVALLAQTPTFAEWPAAKLVEVNGAVRNALTKIDVLASWADEPVDEEGNKVEVPATLPAQLVATAAAPNPDRTFADPVARIAGKTGEQSKSWHAIAQRFLFPEAFQLEGEFETKLRPDLPERNFLITVTENRRLTPDTYDRNVFHIEFSTEGTGLKYAIGEALGIHGWNDEQEVRDFLAWYGLDPNAVISIPSREDSSRVEQRTVLQVFQQNLDIFGKPGKSFYETLSKYAKNKNEERALRFIACPDGQATFKKMSEMDTVTYADILRQFPSAHPPIEDLVREIEEIKPRHYSIASSQNFVGDSVHLLIVTVEWQTPKGSPRYGQCTRYLAGLKPGDQVMASVKPSVMKLPPRDEQPVVMAGLGTGAAPFRAFIQERAWQRAQGKEIGPMLYYFGSRHRGQEYLYGEELEAYFQEGVVSHLGLAFSRDTDKKVYIQHKMNEDAELLAKMLEDAWPVPDVYEALVKAFTGAGKTVEEAQAHIEELKEEERYILEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD93</accession>
    <name>A0A2S5BD93_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD93"/>
    <dbReference type="STRING" id="741276.A0A2S5BD93"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="80661" checksum="D3D2E876DCBE62B3" modified="2018-07-18" version="1">MAKTTSKRKQTRNFLQSGQLKSQIEARHKKRAFEQKKKGRDAKRNKGVLPAHQRPEEDDDVKEEKAFEEVKKRKQEQQEDEDEDEELDVDDVLGAAGLGGGDDASGSEDGGDDGDDLEDDDLSGLSDDEDVGAANPMVDMQALAEKDPAFYKFLQENDPDLLKFDADATGDVDTSDDEDEDEEEDTAATKKGKKAKKGKDVKGKGKENVLTKEMLRGWQKEILETRSLRAFRKLLIAFRSASSAGSDPETADEDRERIQIHDPKLFRKVILTTLKYTPLVLGSFVPYKEVNGKFKLSTNSKQYAIAQRLLKSYFVSLHALLASVSSQSDIPSYAVTESANLVPWIVGNRKIARGWVKMLIDVYESASDEVRVQAFAALRKLAIAADHSLRESIMKGVYATLLGSSRQTSAYTLPAIELMKFLASELFLLSGKQESDLAYQLAFSYIRSLAILLRKGVKDASKEAYKNVYNWQFVHAIDFWSMVLATAGDKQRVAEQGESPLQHLVYPLVQVALGAIRLVPTSRYYPLRFRLVRSLLRLVQRCGTFIPLAASLFEILDSPELTRRSKPSTLKPLDWDYYLKCPTAYQRTRVYADALADELVYLLTEYYGALATSVAFPELVLPAIVALRRHAKKATSGKVATQMKQLVERLEANTRWIEQKRENVEFGPNKRDKVDRFLANEEIDKTPMGTHIKLQRKLREAKKATMERALHQGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDA7</accession>
    <name>A0A2S5BDA7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDA7"/>
    <dbReference type="STRING" id="741276.A0A2S5BDA7"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="710"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="757" mass="85245" checksum="F4782255E8AECB7F" modified="2018-07-18" version="1">MAQQRSVHDHLLYVSLDDVHFFGGIYTVIKTKAPVTCAEYGDRYTLIGPLSYKSAPMEVEAIEWDKPTPLNEDGTPTTTNTANDALVGSLSSMRDRGVKFLYGRWLIEGGPKVLLFDTGSVYNRLDEWKGDLWNLAGIPTPPNDAETNETLLLGYLVAWFLGEFSARERSRAIVAHLHEWQAGLAIPLCRKRHIDVTTVFTTHATLLGRYLCAGSVDFYNNLQHFDVDHEAGKRGIYHRYCIERAAAHCADVFTTVSHITAYEAEHLLKRKPDGVTPNGLNVTKFSAMHEFQNLHAKSKQKLNEFVQGHFYNAMDFSLDDTLYFFTAGRYEYRNKGLDMFIESLARLNHRLQQMGSKQTVVAFIIAPAATHSYTIEALKGQAVTKQLRDTVTEIQNRIGARLFERTVRYTGEHGTEVPDPNDLLSNEDKILLKRRVFALRRNSLPPVVTHNMADDANDPVLNQIRRVQLFNRTSDRVKVVFHPEFLNSNNPILGLDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGVPSITTNLSGFGGFMEDLLEDSQDYGIYIVDRRMKSVEDSVNQLTDQMVSFVQKTRRQRINQRNRTERLSDLLDWKRMGLEYAKARQLALRRAYPDSFEDDDFDFSDNQVRIPRPMSAPASPRWQSGLMTPGDIGTLTEEMQSLGTSDYAGAATWESLIRKGDKAEDEEDSYPFPLVLKKSRNGSVSSVASASGRTTPGATGAHNGAKATLSEGDLMRADQALSQHSSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDG4</accession>
    <name>A0A2S5BDG4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDG4"/>
    <dbReference type="STRING" id="741276.A0A2S5BDG4"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16069" checksum="94276B5FBB4A13D4" modified="2018-07-18" version="1">MFRPGVPLPRVPEHLRAAEASPEGHADLSSVVTKLALFTVAMVLFPIGTYYLTRDYVFAPTTSLTYPAICAVTMANAVLVAFIYIAFREDMLDSAREEHERKSTEREKQAQLSKEAVTATATGVAPSGSAAPALGDKDGAAAARRTRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDI2</accession>
    <name>A0A2S5BDI2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Legumain</fullName>
            <ecNumber evidence="2">3.4.22.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDI2"/>
    <dbReference type="STRING" id="741276.A0A2S5BDI2"/>
    <dbReference type="OrthoDB" id="1714508at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="318" mass="33855" checksum="57A373CFA7840595" modified="2018-07-18" version="1">MQSLVGYGSDSDDESRPQQPVAGPSSLTGAAVAYAVEDAPSDRRTAPPAPQPALTRIKGAASARSNSPLSGVRLPTSTGNSPRSGPSAASLGKRRESSASPPPFARADAGRTERNGSESSPAPSAAGSSGPAAYLNTLAEFGIPPIPTGPCAPSVQAKLANFHNLRLSRGLHFNDSLHASKAFRNPRIYAKLVEFVDVDESGSNWDPEIWNAREIGPDATASRIAELQKIRSEAKQTGASQRSSIAFAPSTTSTSASSRAADDPRQAGLSRRADDGRGEREYRPRDRDREKDWDRGGDGKRSRWDRGGRDRSRSPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDS3</accession>
    <name>A0A2S5BDS3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDS3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDS3"/>
    <dbReference type="OrthoDB" id="3365563at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF13">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="47153" checksum="8828C48CDB8D21D4" modified="2018-07-18" version="1">MVNIQITTRASLLLHAAGLISIYSLYGVLQEKIMKSSTYSPHKEHFTSSSLLIVFNRLFSTSSGLAILMHKTRQQPENGSFAQRLKPASPYFAYALVALCNFLSTSCQYQALRYVSYTTQSLAKTSKMVPVLIVGAVVWRKKYMIREWVAAGVILAGCATYLFAAPPMSHGSHPKTSSLSDHSALAGILGAAYLVGYLFFDGLVSTTQERVFGKNPSSSDPFGPESPVLDQMIWTNVFSASIAVAASVASTAVGDFWPNVKLLLTSPSLIWDVSVFSAASALGLIVLLNTIASFGALSSSLIMTVRQFLSILINAGIFGNFASVSLLGWTGVFWVASGIWIKINRNYDPPKQPRNTASSAAAAATSEGDEAKESLLLRTEHASIGNTLGEEVLAPPSPPVAYKQVVLQYLVPIAIPAVAALLLAPFVEGRSSISLESGTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDV8</accession>
    <name>A0A2S5BDV8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Xeroderma pigmentosum group C-complementing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1907</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDV8"/>
    <dbReference type="STRING" id="741276.A0A2S5BDV8"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="745"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="799"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="10">
        <location>
            <begin position="869"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="972"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1143" mass="124285" checksum="19EFF1DC8CCA91F6" modified="2018-07-18" version="1">MSRYSTPLGSASASASASASDSEYPLSTRFNPRNAAASMHPLASGSRANYYDDDNDDVSRGGDGLQDDEDEEEAWDEVDIPQAAPSTAADALGSRQDANQGGTEAGTSAGAAAGGIEIVIGRSAAANGKGKGKGVVSAAELTDACRKGKGETARERMIRQERHKVHVMALLAMGLIRNRWLNDPELQARLVSQVPAALLNAFTLITPSRYPNSRDRSRLFDRAVSDLTSWWYTAFEIVPDRELSRRDVVQVEQELEDWREEGERLRLKAQKRVDAEKERAAARQGTDVKGTGKGKAKAREPPLEPEKIPLYPWQESPYLLTTSRRDSALDKSASTSKLPLHPSSGQLIRPYEPASSSWEVVRPAPTEHMQSFHVAASTLRGSKDLSAQLFVALLRAIDIPARLVVSLQALEWRSRAQTTQPPAKPKRGGSAAKPRGGAKGKGGRVAGRRRAAPAQKAKALDTTTDDDDGGGGGEEEEGDFRAIDEEATRASRKSAKAGRDAKSTRRKPNGSGPARARGDDGGTGSSTASVSVGTAGKKKVTSSKRSSAGKPAPDVLVLSSSASATTGSDTDGSFEDGRGKLQYKVPKVKLRGSTSGARMAAWKKEQELKRGTSPDAYELSIAPTQWVEAYTRYNKEWIVVDPVRKRMRCAKLMEPPRAAARGGGEGNVLAYVVAYEEDGSARDVTPRYARAFINVTLKSRVPTSSKVRKENGGNDWFAGVIFPFGRGFKLNRDVEEEEELWHRQSNAPLPTSIGGFKSHPNYVLEQHLHRDEALHPGSRSLGLFKGEFPIFRRSDVVNVRSSENWYRTGRVVKSSEIPMKFVKQRAVTIHRRREEELARMDGGEVDEQPLFAEEQTEVYVPPPVVDGKVPKNNFGNIDLFVPSMLPAGAVHLRSKYAAKCAKELGIDFGEAIMGFEFRQRRALPVISGIVVAEEHADTLEAAKQQDRVLKRWKKLIQGLRIRQRLMDQFKDTDDTPIDATASPPQKSLATQKKVPPPAAPIPSPPVATFQVAETAETEAKPPPSKVPRGRKRATISPSASDEAPSPKRVTRSGDKGALSGVSTSGRSLRVRLPKREELEDQRSEPTRSRSTRASAQQAKGRLKLDDDGDGSEEESALASETVANDEPAGSGGSEAEFEFDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDV9</accession>
    <name>A0A2S5BDV9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1923</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDV9"/>
    <dbReference type="STRING" id="741276.A0A2S5BDV9"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="607"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="814" mass="88243" checksum="FC6BAA2E0D129F66" modified="2018-07-18" version="1">MPRRSSGSDAHNRRSSIANPSSQPATPPRPSPATAGPGHARNPKMAVLAAANRLRDTTGTPGRSVSGTLGAAPLVVESQRYEEWMKIATDNKITSTNTWNLALIDYFHDMSLLRNGDDNSINFQKASCTLDGCVKIWTSRVDSVATETGKLLSGLGDDAQPMDDEDMDGEGEDGEGRPEKRARKRTARQAATLADDFAKLRVKQFDLEFTVDPLFKKTSADFDEGGAGGILMNHLGCDGSMKVVFDAGDAKLDCDEEDEDEDEEAVRAKQAQDETLQVDLSRLRDRCLPAGLDPLASMTLCPSLSFFRFSDAHLDLGLLNLGGDDDEDDEVPFGARKTTAARRDLPEGGDDDHAVDFGDAYMNQDFGGGGEDFGGDADDGVDFFADQFSSEAVAYGLAGAGPVASGSGLGNSTGGGGGTGFGAVEPFDPRRMADERDLVMSMEGDGDGMFEYFDAKLGKNWAGPEHWKMRRAAAVKKEDGAPAAKKERKEKVAFSIDFSNPPPLSAKELFASANPKSSITTATRKTARKATAVNGEDNFTLPDDYHFNSQNLLRLFLKPKMTLRMRRRNVQLGEPTGGEEDVRFWAQAGAAGGALGEEGYGGGMDPMDHDFNQDFGGGGDGDDDDPPPFDTQWLAGGEDDFSPDLEDEEGGGKELDDLAAATQGQLRRVRPEMVSYAKRAKRVDIKKLKDSVWRELEEVVLPVKHYPESPSYDPKEPLPEVVEATPAAKDVKPRKKAEALVPVVSGLRKLYPKDKMEEISTSFMFICLLHLANEKGLRLQTPRFEQDDEDAAHDADMQKIVGGLESLRVLKEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE41</accession>
    <name>A0A2S5BE41_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">XRRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE41"/>
    <dbReference type="STRING" id="741276.A0A2S5BE41"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904868">
        <property type="term" value="P:telomerase catalytic core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045537">
        <property type="entry name" value="Lar7_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19977">
        <property type="entry name" value="xRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="XRRM" evidence="4">
        <location>
            <begin position="541"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="670"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="715"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="758" mass="80101" checksum="723C274B9384F4A3" modified="2018-07-18" version="1">MDSPDSLFSDPASPSESPAPTAAAEDVTMTSPVDDKVELPTQPNTPATATASAPGPAFVPRAIKRTTQGARRPAAASLATVGAAAASSSNGPPPATTRQAGPSTATDATETDANPLTAPKKLTRVEHDHLEAVLSAIETAFSDYGLSVHGKGALLDRFVDAEANGKECWIHISQLLQNPAVRALTGSITDIQRAINLRESDILQVHASGYQLARKEAPDTKRLVHMEPADWDGLVLYTESIPFAAATSSDRSLSRFLSSALETPVQRLVLPALFDSASRSRPQEDDPASANGGQTSQAQAFAQSRGGPNKGLGLPKGGGPFRGFAFVVVRTAEDAERVLATYPWKREKRERAEGTGHEDAEEEAEGADAPQGESAADPKGKGKAKKEKLSPAERSKRGGMRSLTYAKWLDLKREYLAYRHSIESLLDARAHNAYTERTRRPAGARDPPPHLANNRPGPSRETAQPREDDAGRRPKRAASPSSPPPAESTAGPAATTVDHGPKRQKRASSPATAFHARVKRLRTPSPGIDLSSDAALDVQGAYPEGCVLWIRNVHESSTRTTLKALFGSLLDQLQEGSSKGVEFVDYEKGLDTCHLRFSSPGLAVVMHDHLTSSPSLHLSQTILTPAASLSPTSLAAATTASRRPLISTKLQGEEERRYWANVPEATRRAARKAAGAKVGLLKDPRSATGGGEEEQNGRGGGGGRSRGKNRRKGGAAKSAPVAAEPPVSAAESAGHGEASTEPAAADAGQPKRKRPSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BED9</accession>
    <name>A0A2S5BED9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BED9"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="258" mass="28286" checksum="B1A52E2255324D02" modified="2018-07-18" version="1">MGFETAQIAQQQQPPARQRRQRVSSTSSVWNPLVSDRWWPTTESELARYYLPTLSYEDDWSDEWVRLACERGVLSPQFEQDAAGRAQSSSTRRGRRWPLARAHSDTSHGAGDSEPTEQIAELDPPPYCSVDPAPLSSAFATCARSSSSPTSSSLHTVPGSLSFFAEVLSDDIGEPEPTSVRRASSAGSTDSGYVSILSRLSRHSSRQSQTTVASQDGEHVDIEQPRGVGVRRKHLSLSIRKKKGGGDPPRPSRPPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEP7</accession>
    <name>A0A2S5BEP7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1609</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEP7"/>
    <dbReference type="STRING" id="741276.A0A2S5BEP7"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015480113" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="66"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="213" mass="23056" checksum="6AB0159F1F3A0E10" modified="2018-07-18" version="1">MLLKATAAIALLSSAVFAAPAQYDQGAARPQVVLSGARQAALNWGADKLSKLGDNGEMHAMTQWGWTDCGLANDDPLKIESLQVTPDPPKPGRNLTINATGKVSKRIEVSDPHRLLTSEYPMQKGTSADVTVKLGLIKLLTKRFDLCEELVNIKSSLQCPIEPGTHDFTASVDLPAEIPRAKFVVSAKIITPDDTEETGCLDLWINFLVPDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEZ9</accession>
    <name>A0A2S5BEZ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BMF94_1694</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BEZ9"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1108"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1137"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1178"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1258"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1291"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="289"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="435"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1130"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="695"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1417"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1430"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="POY75323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1469" mass="157431" checksum="E0A521F0FDBFBF5B" modified="2018-07-18" version="1">MDAPPSAETAPPRTLAPPVPTVSISPAAATDASPPVTPPGSPSTTTTRRGAHLTNLTPPPPRTAAGLNHESDSGSIATTSAPPSPSSHYLTSLSLRDNTDPDGTRRLREAEAGGYSSSFTGGGGGGGGHERRPSYASTVPDSYVESSMTRKDTVDSTSTKAPLYSGPTSPATHFLAAAKPTSKSTETRSPRDLEKGLDAAGKPLTLDPDNSGRVMDASNPGIEDTELTAAPEKRPKLFGIFPRRARKPAEVVAIVDPPAEEMQPFDRAMLPTALYNLVDPKSLDHLTSLGGPEGIMRGLRTDPKLGLKEEGGADGPQPALAEDRKRVFGENRIPGKKPKSFLALCWAAYTDKVLIILSVAAVVSLALGLYQDLGTPASYYPSTACPPTNLCKEPQVDWVEGVAITVAILIVVMVGSVNDWQKERQFQKLNAQKEERNVKVLRNGQQRLMSVYDVVVGDILFIEPGEIIPVDGVFLSGHNVRCDESGATGESDALRKVPYDELVGEKAASSSKADCFMISGSKVLEGVGSYVVTSVGRNSFHGKIMMSLQGDTEDTPLQLKLNALAELIAKLGSAAGLLLFTALMIRFFVQLKTDPDRTAHEKAQGFIQVLIISVTIVVVAVPEGLPLAVTLALAFATRRMTKMNLLVRVLGACETMANATCVCTDKTGTLTTNKMSVVAGSIGVHLKFAARLAENQKRTNANDDRDPEQVSADGHDDPSAPPSPTSSDGQGSAPPKRKGRLDFSADMSDINEHASPALKKLLNDSIVINSTAFEGTDEHGAEGGFVGSKTETALMSFAQAQGWPHYRAVREGADVVQMVPFSSERKCMGVVVRLPNGKYRLFLKGASEVLAKLSTRHVIIQEHGAGASTKEIDEDTVPTAEFDEETRGNITRTIIFYACQSLRTIALCSRDIESWPPRGSEVNADGEVAFEDLAKDLTLIGVTAIEDPLREGVAKAVATCQGAGVMVKMCTGDNVLTARSIASQCGIFTKGGIIMEGPVFRKLSDRQRYEIVPNLQVLARSSPEDKKILVETLKSMGEVVGVTGDGTNDGPALKTANVGFSMGIAGTEVAKEASDIILMDDNFASIVSAIMWGRCVNDSVRKFLQFQLSVNITAVIITFVTSVASSEESSVLTAVQLLWINLIMDTFAALALATDPASPESLLRKPDRKTAPLISVQMWIMILGQSVYQLVVALVLNFAGHSILNLNSTDPALSIDQENELKTLIFNAFTFSQIFNMINSRRLDRKLNIFTGIFKNYWFILIFCIMVGGQALIVNVGGAAFQVVRIGGRDWAISIVIGLLSIPLGALLRCLPPGPFHRFLVKMHLYPSDAELRGELPNVSKAAEEYKWSEGIQKAIDGLRVYSTVRGGRARASNIFKFKRPMSRNKQLAAMDLQPTYLMAMVPSLVIGSIGGGWRPESGTLENPAAHDPSASTQQLLERGSGQLQNGHSRSPSMSTTLPAVKEESRTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF41</accession>
    <name>A0A2S5BF41_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF41"/>
    <dbReference type="STRING" id="741276.A0A2S5BF41"/>
    <dbReference type="OrthoDB" id="2588793at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="431" mass="48574" checksum="EF5D1473DD25FAF1" modified="2018-07-18" version="1">MSPSEASQDGYELVPTPETDPDAAAADDPLDLSAGPPEVRQRRTVERSLMRSVIVLALVVSVVMGGSALWAMWKPASWSENGLEGVGLHIWRGKTPTEIRSADATSLVSEGSAQLVDDSSLPEAVLARAPSSFDALLEQAAMNLTTDPRLDFMRGKTVILAGDSHDRKNIEGFCEHHKRVGARIVSRGGHIITRCEIPVSQPLRRSLRASAYLPTDLNFKLVNWFHYGMPERNESWYGPTLSPKMDPPPYAIEDRLASVFLPDLVELGITQPDLLILNSVYWDLRYFARKAEHEGWSEELRRSDRALSWRELAWHRGRLVQFVELFRRQFPGVPMMYRPAQLRANNDKAGNVAVFQINESADFVMQQLGVPIFPWSSLLIGEEDYADDMHVNIVSQATYLHGDMLLYYLQRVADDSWRLQDSQGRCPGRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF61</accession>
    <name>A0A2S5BF61_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF61"/>
    <dbReference type="STRING" id="741276.A0A2S5BF61"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="159" mass="16310" checksum="27AC9CC0CB62018B" modified="2018-07-18" version="1">MVRVQEVSDDVDAWSSASSDAGDSDVDSVLSDSDLQLDHYDPSKESYAERIAALKDMVSPTTRQSLADAASSTAGWVKWSLVKAGNVAWIATTSALLVGLPLLLSIEGEAALVQQEKEYMAQPGAQNPYGAPPPAGTLPGQAPAAGGAAAPQGLVPAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF82</accession>
    <name>A0A2S5BF82_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF82"/>
    <dbReference type="STRING" id="741276.A0A2S5BF82"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="592"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="621" mass="66688" checksum="DF16A0168B4458BD" modified="2018-07-18" version="1">MTPHKRTLPADLALSDPTRPPASRRRALASSLYDPVTSPWTAQTALQAHHSCVNALSFSKHDGGRYLASGGDDKRVLLWDTARPDQDGDDTQGIAAEPLGCYRGATSNVFTTAFTCDGQKLLSGGNDAVVIVHDLETSSASFPHALHEGIPPATAFIDPGDAIMSISPHPQNPALFIAAAADNLLLFDLREGVRSIAATSGHYTMDHVEHHPLSPELFVYSGDDGNMGLLDARTAWASPDYPGTEYLNVADKTALHKYHANLVRAPGKSAKPTLSSFTFDSTGSIFCATVSGYLPTLYELSEPTPLATFSSPAPAAPAPSPSPTSATAGAEPLAFPEGYRNSTTTKHGSFGGGPGAAPGQGLYYAAGSDDFRTYIWEVPSLDSLRERKKQSLFGAQSAGEVAYYDGKSTSVVVPAGVTPASSILTGHRSIVNTAIYHPTLPLLYTSGIEKHIVRHSPAQPRSVSLEATETGISSPRGWRFIPRTPEAHFIHPGLTGPSDPCHDPTLRPGETHRERELRLRSEDREVLEYFDGLVEAEGEDMLWREGRTRDDDDGSDFGSGDEEFDEESLDRLRELMEAGGPLGSTRRVLNQLYALEGDSEDGSSDDEEEEGEDQDDEDAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF97</accession>
    <name>A0A2S5BF97_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF97"/>
    <dbReference type="STRING" id="741276.A0A2S5BF97"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="82313" checksum="1E00FB1774F6DCF4" modified="2018-07-18" version="1">MADISDLLTSIRKTRGDGPPPLVGASVTVVGDAIFVFGGRPVDSREMVNTLYRLDLQRFTWERLTPSGPSPRARLAPKRGSESVQGDALDVLDSLSVYDPSANTWSAPVPTVAAGATRPPARFAHLAVTSTIHTPAAVGGPSPVSTPETASRLLVVGGQDDSNAYLMDVAVLDLDRMEWISNGPYASKISAYRCCAASTSKIVFPAEEKLLGNGSRLIFSPHAEDPTDESEGPAYIINHRREVDIFEGLHGGTSPRYATRSSSEVVAPSLRFPTLATCGDHLVLSGVHVEQDCAQYMVYSSRNSGSWSQGAGWRDQLVILGSSDRDMSADYRSRQTNFEHVAIVDLAGFGIFTPPARVLTPLQQQLALQQAAQIALHDFAVTGSDGHKATCSRRLLMARWPWLAAAALGAEQQATPMRIPAGNGAFFLLDAQTLHLPLCSPALEALVLYVYAAAFPSPAQRSVEALGPLLEFGFTYSQVLPDLHAHASQALHELLDQQAEDVIAVAQVLEAATLGGSSALQVRASLAMAQTERRSSTTSSLSLPYLRPPSSLSSGAVSPASHLSLEAIRVHPRTSAPPQGSLPPTPSTSSLGSEDMQARQLQSPLTSISSSTPDHIAKAWWEAEERDQIQRLDALRIAVEADIAKSAAALRLAQEQKHQAERNAIASSRPSTATALSSDETASIRTSNSGRSDSTRLSAEKPVVAAAAAARAVKKGFFSSLVSGPTIHNAGVARPKTAGPAPKRMYPAPTPRTAKGSSALNARQAGSSVASSASSCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFC2</accession>
    <name>A0A2S5BFC2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 4 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFC2"/>
    <dbReference type="STRING" id="741276.A0A2S5BFC2"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="4">
        <location>
            <begin position="170"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="5">
        <location>
            <begin position="455"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="630"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="978" mass="109017" checksum="1D6A95DEB2A63860" modified="2018-07-18" version="1">MAGSPSLKTPRKPGAVSPDYLQGWTTTFATYGSARRRRLTVPTLAIILALVVWKTWTPIPYADDLDTPTTSWGKSAFGYKATSRSERSSSRVGSFRVNSDYQHSDLQHPRKRKIDEALALSPNPLPVHHIHEQIHFHNTPLSPHRPAQNQFVRASDSRTYRQGGPPPVISIVTATQNPRAVMMETATSVLGQSLQNLEWVIVDDHSTDPDSLAMLREIAKDPRVIIVPNEGAKGLSASRNVGHRWILSPERQQAGTIPKYMASLDDDDLYEFTALEKTIWMLESNPDWDLGGFHVIKFGASNETVTSGIHSGAANFFSGNFVPNAAVYSSRAVLRSGCRYDDVNFAVGGEDWDFWLCLAENGHWGGTVPEPLFWYRGNEATFRKQRWGNLFVDGFAPLKARIDDKHHGLVQSGSFPDIPPRPSRQLDAITWEAPLQNHLAHFEKSIMFVVPWLFVGGADIGALHQIQLYAEQGYRVTVVCTLYRAPAGLELRPHVLQYTHDVHVLPSFLNAADFPRYMKYLLNSRGIEDVVLCNSQLVYEMLPALVEQVPHVKFIDYLHNEAYNGWKSGGYPTYSLLSQRYLSRTITCSSYLRDWLIARGHADPAAIGVVKLGIEVSDFSPVPDARKTEKKKKLLGVGPETTVISVVGRLDPQKRADLVPDIADQLRKLGDYRRDDFVIIMLGDGDLKDKVKARIAQFRVHEFVRVLGTIDAPQEYLAATDIFLLPSMSEGISIAVAEAMAMALPIVTANAGALPEQLGFDDGDPSLVAGMLIDHNLDAAHDAPLYAEALHSLMLDPVKRKALGMQGRRNVEKTFNWRDTLRGMFDEVGKARLPDPGRAAHLPHPAAHYAIQNLLIEAHDETDYTAVWTGMKAPVRSGAGRILQERCGESSKELSLWIDKLEQPRKCDNAKIKAALGSNKLQRSAKFQCGAWCIYDLTRTDYAGWAFNGNCWTPFDEEVPLHCKEFWSSRPAGINLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFD8</accession>
    <name>A0A2S5BFD8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFD8"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="780"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="814"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="825"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="93724" checksum="5101D5CAAEEC22F1" modified="2018-07-18" version="1">MTGAGGSSRQHLPADQADWSASFDGAATCPNATALSTSVGSQIESRFHLPPHQLASDGALYEGDAPNVLADNVLLHPHTAHLASTDPTGRTSARPGLGSRTSSWHSALWATEDEQDERGRKRSDSKRRKARGDRGSGPAASPSPEAEAGHGAAEDEEEDHRDDYARSKSQRRKMPWYRRPSPIWFFPGTLVIALTMGMTIAPKLEIYTQLICRALPIDESGVTVPPPVFELGRGPRQPTPILDKHPSTADGQLGNATAIQLDWQRDAASPVQHIGSFATGSAPGSSVSSDGEWAKQCHKSRAVQSQVARLALLLSLLMGVLSSLTTGYWGAFSDRNGRKPVLILALCGSLAMDVVFLLTVYYHSTLSYNFLLLGPFLDGLVGGWSTAQATSSAYISDVTSPGSRAKIFSAIGGLMYGGFAMGPFLGSLLVKHSRLSVLAPFYAALAMHAAYLLFLAILLPESLSPERKQLARERHQAEKLERRRLEREGPKTRGWKRVAQIAARPLAFLKPVALLLPQKPATMNEAGEPVKPEDRTNIEYGAHLKDYWSPEEIWKSPDPNRMLATPGGRGAGKADWTLSKIALAWAAYMTLMAVMSVKLMYANFTFGWGPVEDGQYLSFLGILRVVMLVALIPLIIRLIRRKPAPLPLRPRPEANSRAASEWDHEKRWLRVVHDSHFDLSLARWSLFLDLCGFLLFLVAPSLVPPSMRGGTQHIALFLTAAVLQSFGSGASPAIQSLALAHASPRDAGRLFASLSVVQSIASQVIGPILFSTLFMKTVGLWSEAIFALATLLAALACLALALIRLRRVVVPESGRGEATGGEGGAADPEAAAVAAAGVRSGSSGSSHAPRDSSPVESATPSSSSRKDGSIATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFH6</accession>
    <name>A0A2S5BFH6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFH6"/>
    <dbReference type="STRING" id="741276.A0A2S5BFH6"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="104"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="218" mass="22863" checksum="9718EC0F7B70FE9E" modified="2018-07-18" version="1">MQSRFPQPLFQTPVSLSFRVAPSENSSRVVSFALPCPRAGGEEAGDHRAIGCRPEESATRSLFRLFRTSTYEHTHTTRSPSFPASSFHATLIETRANGPPPRADVKDIGYVINYDMPNGIEDYIHRIGRTGRAGATGTAYSYITPDQGRLARDLVKILQDAKQVVPPQLQEIVGFGGSSRGGGGFRGGRGGGGGRGYGGGGGGGGYGGGYGGGGGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFN4</accession>
    <name>A0A2S5BFN4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">molybdopterin adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.75" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFN4"/>
    <dbReference type="STRING" id="741276.A0A2S5BFN4"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="5">
        <location>
            <begin position="483"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="727" mass="77075" checksum="4D31BDB54156D965" modified="2018-07-18" version="1">MPHREPVVEDLAVLLLLGGQSRRMGTPKHLLQHPLTQEPLYRYHLSTLLRLSAEGTFPRGVWVSARQDQLDTVDLPEVGCFSLASLPKHPLIIPDIQSVNTVLDDRETHGDIGPAAGILQAAATQPDATWLVLAVDLPFLSGDSISHLLANHAPASPVSLYLHSDDGNPEPLFSVWTPLALDQLRQNCQAGKSGPCRAAKDVWGGKIVEGKGGVKVPTEAWITDADTPEEWAEAQKRLHGIEPAGTTDASTSTATHCTGFAKVAYTATAFHDAVSLVRSLPVKRKRRAPSTTSTGQFGRGRPFDAEGSEPSGAGGYTSQADIHALLPHPLEDNSAMDGYAVAASAIAHASPAAPVLLPVLGRIVAGDAPPVCSDAASTGCWEIMTGAVFPSPGFDSVVKVEDASRTESLDARRRHMIAFSAPIHPGKNRRRRGEQFESGDVLLRVDEEVTPEAVMLLAAGGVQHGLPGREVQAHRSSRRGRVAILATGKEVVSLSDREQSLAPGQVVDCITPFLDTFLRSRDYEPVHLPPCGDSLADLSSALSTALATESFDLILTVAGVSLGSADHTPEALASIGLTQQFHGVAIRPGGPVMLSLHEATGTPVLSLPGNPIASAVCMRAFGEEVLRRLEDDEEDGREPEEWRPLDMKGANEQDGGWSAWLDRQKAGVSTFAAVPVGARGTPVAPNGVLGSTCGGPCALRSLIGAGAWVRADGARDGTPCRAYWRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFP5</accession>
    <name>A0A2S5BFP5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFP5"/>
    <dbReference type="STRING" id="741276.A0A2S5BFP5"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00660">
        <property type="entry name" value="Topoisomer_IB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="466"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="939" mass="104917" checksum="6FC7D8AAB3303EAC" modified="2018-07-18" version="1">MSKPYKKRIIQEDSDESASEEPQFKRPKPTDDVLDPSTGASNGKTLAVPNGDAPTGQVDTVMNDATAEVVDPKAKQLAVFTTGGSDDSDTGHDNDDDDDDDDVPLAQKAKLAHVAGKGPVPGVDNDGDSSEDDKPLAQKVKANGNANGKKGPAAVARRSRSKDQSDSPTTAGDDGSSSSSEDDKPLAKVTQAKRPRASTSRAKPVKKEDSDDDDGESPSEAESEDDYDSDSDAPLSAKKKGKAKAKPAKKAVAAPKKAPAPKKATAAKRVKKEDSEASASPAPAKKGKGKAKKEDDEDGSVGSEDDDVHKWWEEQNDGEEKWKTLEHSGVMFPPEYEPHGVRMKYNGKEIKLQPEAEEVASFFAAILETDYVKNPVFVRNFFNDWKKVLKQHPCPDGTEIKEYDQCDFTPIFAYLEAEKAKKKSMTAAEKKVAKAEKDKVEEKYKTCLLNGRKEKVGNFRIEPPGLFRGRGEHPKTGMLKTRVRPEQITINIGKEAPVPQPPAGHKWKDVVHDNKVTWLATWKENINGNVKYVFLAAGSSLKGQSDLKKFEKARALKEHVDRIRADYTADLKSKEMAIRQRATAVYLIDRFALRAGNEKGEDEADTVGCCSLRFEHVTLTPPSKVSFDFLGKDSIRYVNEVDVDEQVFKNMRIFKKEPKTVGDLLFDRLSTQVVNKYLASYMDGLTAKVFRTYNASWTFAQQLKNTPKDASVADKLLAYNRANRLVAVLCNHQRSVSKSHSAAMEKMTDKIRGLKYQRMKLRKQLFANADKPKKYKEEYGDDESDLDDEWIQEHEKQLVVLEGEKIRKKFDRENSKREADGEKPMPEKELKERLKAADDLEKQIKRDRKSGYEETKLSEDRIVNNLQKLDERIQVAKTAAVDKDEGKEISLGTSKINYIDPRISIAWCKEYDVPLNKVLTKTLLEKFTWATGVDADFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFR4</accession>
    <name>A0A2S5BFR4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_1223</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFR4"/>
    <dbReference type="STRING" id="741276.A0A2S5BFR4"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="163"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="427"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="631"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY75601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="727" mass="80316" checksum="31D6314E88A0479B" modified="2018-07-18" version="1">MADRRRTTMTTHSVGGAGGVPSSIPRPPNTLRHSLAPNAGRASMAPGAGGAASAFGRASGRASMAPGAFADSQNSQSAGPPGASQGSQFSQGHGGPPHLVAPMTASRAANVYTSFGASQSAIKSQSVLRTSMAPDYAPASERRGSTFRRSTMANSVMATPGGHMGIGASSRANAVKDPRDARPRVVRERMAQEIVDFCELRQHSVALRELLQPTGNQFYNIFEYLVKQYAGISFGDMLGNKAKKEDECLAILRACQYPFADSISKSHLQAVGSAQSWPNMLAMLHWFVEMMNSRNAAFDSYPEIHMPAPGYQDRLLDGELAPEVVISHAWMDHLARVYARFLNGEGEQLEPGNEDSPTMFAAEEDELRDTIEASSGAQRQRLEAIRAEHANLLGQWEKLESKPDPVHAYTEHCSRVKRDVEKAHVYIEKTKATIAAIAQQKADFEEDIQRALRDREEKRDQQAQAERVVRGQKLTPLEIQSLSSERAALTRQMQDVQQRYRTAVSRTMNLEIDLNKRIDEATALCARYEEKAQPLGLLNGPLEGYEDIPFAQEINGASDNPVPEGLGTEVKPALSKLRQKTRDEIRDVNMTDFRIESELTKLKEILADLREKETVEVQELDVVDHEKGQMQEAMDRELATTGAELERLQNQVLAVQATMNDALAAANHRYEQRVVERMAAYEQTSALRRKNRDALEQAIEQFMGYKEHMTDGTDRLATLLDEVAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG38</accession>
    <name>A0A2S5BG38_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_1145</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG38"/>
    <dbReference type="STRING" id="741276.A0A2S5BG38"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="14">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="15">
        <location>
            <begin position="243"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="17">
        <location>
            <begin position="488"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="16">
        <location>
            <begin position="581"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="13">
        <location>
            <begin position="719"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY75735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="854" mass="93791" checksum="527741660379DC99" modified="2018-07-18" version="1">MGHAHTQSAFFSPASAAEPAANIGFPSSGGGSVPANAYPQPGQPAVQQQQQPQPQQPMAQMTSQFGQMGLNTPRPAHDTRTVNLVNLPLNPLELMTTMPPEINLPPTASFSQSPTRNADPSYQRSTLNAIPTTNTLLQKSKIPLALVLTPYRSLKPGDPEVPVVSDTVIARCRRCRTYINPYVTFIEGGQRWKCCMCNLSNEVPQLFDWDQEKNEAADRYARHELNSSVVEFVAPTEYMVRAPQPPIYVFVMDVSYSAISTGMVATAARTLLESLDRIPNADDRTKISLICVDSCLHFFTLPEGSSEPSMLVVGDLDDVFLPKPNDILVNLVEAKAGIENLLTRLNDMFVETNNTGNALGAGLQAAFKLISHVGGKVVALSATLPNLGPGALKNREDSKILGTTKESTLLQAQTSWYKTFAIECSRSQVSVDMWLFSSAYTDVATLSGLPRYTGGQTYYYPSFNAARSEDALKFAHEFGTVIADPICLEAVMRVRASRGVRMSAFHGNFFVRSTDLLSLPAVPMDQSYAIEIQIEDPITAPFVVFQTAVLHTTAFGERRIRVVTLALPTTSSISELYSSVDQVALATLLANKAVERSNQSKLEDARDAVHNKLVEILGTYKATMTNSGSGASPQLVAGDNMKFLPLLMLGLLKNTGLRHSTMIPADVRAYSQALLTTMPSQLLVPYLHPVFYSLHNMPKEKLIIRAPNAQCGTISDQGVVLPHPLPLTSERLERHGLFLIEDGQNIFLWVGRDAVNQLVLDVFDLPSYADLRSGKGTLPVLDNAFSQRVNAIIGKVREARRGPYYPHLYIVKEDGDPALRQWALSLLIEDRMETLPSYQQFVNKLKDSINDKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGP0</accession>
    <name>A0A2S5BGP0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1023</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGP0"/>
    <dbReference type="STRING" id="741276.A0A2S5BGP0"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="273"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="513"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="376"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="765"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="731"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="851" mass="93951" checksum="90951D677D39E973" modified="2018-07-18" version="1">MPLSGIATKQATDPPDPAPHADEKSSTGSVDGGASSRQQRSNDDDDDDDAEEQAAEELLEEEEAEDQDRDEDPPGFTGYVRRLIRRKGGKPPAPEELDHEHNVLDPLAAVDSRYLPIISGLTCPFSVLLEIPGLTEPWYVRTDGNVVVESRPNPVALDVGLAISLALGVFANACLVARFLEFRPKRFTLLAIASLTVHDLINIGAVTWFGVSRRHADGFNYGDTFWETVASTVASTVCNITLTLDLARTRDFVRKGSGLTERQRALMITVMLLFLYLGLGALAYFYLIPDLRVIDALFFSEVTIFTVGFGDPVPRTAGAKTFTCFYASFGIILFALTVATTRDTILETFELSYRSRRARLAQKARERKELHLQRARRLAGRRQYRSESLPDGSREAAGTASNEKVDDNAPRTAAASRVQRARSLATTETRLSRSRTWHHLFHRKKAHSSDESEAPGGTLAATDGGAPLDRRNSTLSLASTQSVDVSFRSLREQLAREEQQEFRTKLSVSVFFFLIFWLGGAAVFVPCENWTYGTAIWFAFETFSTIGYGDFIPYSAAGRAFFIPWSIVGIGNMTLLFSVLSEAWSSRYKSSLQTGRMRRLVRRRMLFLKEGVKPHSEKQTNRDTLARLLDTEGYQSVAREPVPLEELPGKIVETIRSFHAHARYFMLGRTGEPPQQLRVLLDAADSVDTQLDTLLLAKTSALVGSAAGRDTKEYLFMLSYEREFDRVVESANQLSTAIQNAGQELAALNAENDRLQAELRQLRLDTGTPDPNAGNGDGEVPPQPVSRTPTLTFASSVPTASSGMKKTRRNSLAVRRTHSLPYTNTSDSTASTGPTSSLGVRAGAAVRKHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGV3</accession>
    <name>A0A2S5BGV3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY76000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGV3"/>
    <dbReference type="STRING" id="741276.A0A2S5BGV3"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="269"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="648"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="768" mass="82994" checksum="7D87DF6CB7506659" modified="2018-07-18" version="1">MARPPLLALEDTPTTEHNDWQVVLSDPSKRRVVLYSRNLNRLSIEPTPPSSPRTTARTARAPREARRRSWSGLSSVMPSEGASEAGSPSSSRASSPLGAGTVRRTAAGSTRRSRDHGDDRDGAESSTRTVVGGLAEAVPESVCPLCFQVLPPGPEASARRTHTPRPHPRRRLFPLLPPPTGFLPDPARGDLSPSSDTGRSEAGEPGGTSYFELLSEANSLANTPTSTGASAWKARAGEVEPPDRSGEGKPRGDGLDSQQMNEGYYARFFDEVSLLGRGGQGAVYLVRHMLNGEALGLYACKKVPVGDSTPSLLSILREVHMLESASHPNIVAYHHAWLETASPTKSRFVPKVPTLHILMEFANGGSLQGFIDARKGSPTTADEEDVLEGHGAAHAARRRRKEARARAIHLLRLEDVLTLFEQVVRGLAFLHGRNILHLDLKAENVLLHLDEDSLLPTCKLSDFGSASSDSYHRERPFFPTPTTGHLPPPDRSNDMWALGLILYLLVFFALPFAEAGSDGDNTKLEEEIKRHPGFFATHPLPRAASARHDLPPSLLHLLSQLIHRDPACRPSCERVLTRLPAIRQDVLQGVYSELGVGTVTRASSAAPASSVWKQLLMRGRSRRSMSDGSIEPSSVADFASVSDPEVVEVQDSEAGDQGDAGAVEPACAGPSEAGQTETLPSQSRVYFRSNLMARNLLLYESLSRSSSRRLLDLPGPMDGPVPGTGVPLWLVALLLTETAVDAAVARPSLTIFLLIVHLATMRLARILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGY1</accession>
    <name>A0A2S5BGY1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGY1"/>
    <dbReference type="OrthoDB" id="10679361at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48376" checksum="BE017E4DBC98D73C" modified="2018-07-18" version="1">MDDSHGVCAAEQNSPPAPEPAALRLPDKILTKIFASVLEYRHAYARSPQHRQLAVLLIKCLTLSKRFYNIVLPVWLGDSKLDLCTERGHEALQRLMLPGSCELIEALEVKFDWTQASNDMASLTAFQNVRELKIDFGPSVPKDRLGRISLPPGLKDVIATLPLLETVLFYPPVLVPREWAPALSNLREFNSDYISLNADLQWCLTKSRMSNLLLVADGAKNAISRGSEIGLIPWGPALKQLTFGVTPSVGRDDLNLAIRHCFRATRLLSDRPTLSRLWVRIMRRDNFRPDDAVQLGLALADLCNCPEVYIECHATLMFTRVNDTPDEFLSVQSLTLYAAVLLYEQSNFASFLAFLKRLPNLKKLDIGFFFFSASQMPHSIESMSTRQLARNFPSLFSLPHCLIDTSLRVVVKNVGFRYSAARGQVPRRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGZ1</accession>
    <name>A0A2S5BGZ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGZ1"/>
    <dbReference type="STRING" id="741276.A0A2S5BGZ1"/>
    <dbReference type="OrthoDB" id="2522283at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="52720" checksum="EEEBD8E95D2DCE9A" modified="2018-07-18" version="1">MAMATGTDLTAAPPAPQSKPRGPEEAPFVPGSYPLGGEGGEGGETTLASNGAQASRDDERKARAALTLPDELLVLVMRKLDELGGPERELKDCSLVCKAWSGPAQRVLFGRSLPVYEAEAARRLRSLLQSRTDLRAAAKTMDLATPLEQNTVSVYFRRAAALLRDAPFVENLTFLHVGLSDKIRIRFYSALRVLPVETLTSYASHWPPLRGNHVVDGHADVRELSRLLCGYRSLKTLSLSGFSSYPGQLDPAACPSHALPTYYLRELHIYSCSLSDSTLFWLLGNSRSTLRKLDLGSCYGLTAETLSAALTLVGSAIEDLTIAMDLEDLSTIAGVRPLETSLLQQMSRLRRIHISTDQIFPPSVLLDLVLLPKIEDISLAYPTFELGQVKQAAEALPPATTLRKLYLDAWETPDLWTDTDRWSVSRAFEGIGVELLLNGLTKEDVERAWYGENLGDAWALLEGEEPVCTLSGELTKLDLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH59</accession>
    <name>A0A2S5BH59_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0824</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH59"/>
    <dbReference type="STRING" id="741276.A0A2S5BH59"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58818" checksum="2E1489DA8A55AECE" modified="2018-07-18" version="1">MVQHSSKFVSAPKSTESPLSDAIFDRLTGWSALDTLPSLKEAKPATVWTSVLCVIVALLIAEQALWRSRKRHLPGKQWQIPIIGQFAESLNPTMEAYKRSWATPLAAVSYIVIGSTTEYARKILNASTFTEPCLVKSAKDILLPENWVFLNGKVHNEYRKSLNVLFTPKALEIYLRVQDQIYRQHFKQWLADPNPNPQPYQLKFRDLNMMTSLRVFCGSYIAEEAAQEVSDKYWLITQALELVNFPFAFPGTKVWHACRAREVAVKHLMKAAADSKVAMRKGKEADCLLDQWVEQQIEGKVRDFTDKEMALVLLSFIFASQDAMSSSITYGFQLLADYPDVLAKVREEQTRVRAGDFESPISLAMVEQMTYTNAVVKEILRYRPPVIMVPYLAKKDFKIDDNYTVPKGTMIIPSFWNSLHDPEVYPDPDEFKPERFMPGGVNSNGMDSKNWLVFGAGAHRCIGVSYVMHHMCGVIGTAAGLMDWTHEVTADSEEVKIIATIFPKDECRLKFTPREVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHI7</accession>
    <name>A0A2S5BHI7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LAA1-like C-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BHI7"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1954"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2142" mass="229633" checksum="C6457A9A6EBB7B58" modified="2018-07-18" version="1">MSSAPRRLSSIDDLQWDSSQLEAAAAAGRGEHFLLTWLSACEKAVTTLPKVSQLASLALRDTGGRNLQFTLEVGEISTGTPATPVATQDGRPHNSKGEGDAGDAAAEHRVTASTLTGSPGQRAQEAIFREQPQLLKALLTLVQPPLPTAPTPPVKPGRPARALIARIITVVLARGDQKSLYDVAQSLLRGVNGTEGKGALEREKEWRIACTYILGEVYAAFGSQIMSLYNDIVTATIRIARTTSLPVILRHSALLCLRKVIDVVAKSMSDQTIRDTLKALKAGLGEKAGAIVRGSAECLLSMSSAAGTYATLAEINEVLMPAFRALEAADFVTRRSLSRLIAGLLAATQVEGSAAPTAHSKPKDASGNNQQDDDEDDGYPAIGVPSTSSSASKTLLSPIEMLAQLASPYNRATSSRRLRNALVDVYSDLFKTLGSAWVEHYYAEVVEHLIDDIGCGAAAGLGWIAWNPRLAERLDPARARYDALAARKAVNILLSDVISAQLLGEAGQIAALREIGTLYLKKWPSLMPNQPGPSKQAILLALDETTGLLRRLGCAPATAQEVIYDPLVRLIAHPSHSVQIAAAWALRTFCNAVPNRLSSTIAQVIELLNKDLTLMTSDGPNQSATVHRRTVGYAHALAALINLIPHKPLYVSFDLSAKCMSLAIQLLKQSGNHELHVSGIEIQVAWILVSALMSLGPHFVRLHLPQLLLLWRNALPKPTNKDASTAQVRGDNEWAFLLHIRECTLGAMLSFLRHNGPTTTSSGLVNEDTARRLALLLSNGLSFANSFTTSHPNLAAEQSPSTSSRLQLVDRDLMYRRRLYQCYVAFGQSAATQQQQIVLLQQTIAVISDPDRYFGESAIQAAATSGSFTSIWEETDNLAFGLTSLIRDGKNEVAGGDELANGTAAATKSKLGRLNRDRAESEIEEQLRRPVLAAGEYDGSVLTQTLASDTSSAFLPLDEAPSPATGLVDAAIELFALYFPLQETGNQAALVQLLLNNSRSFKLDKNPGRRQAILANAITAVLGALRLARRGIESAQVASPMRDLVKEALLHPDASLRQAAAESLGRLCALGGTSFMAGQIQACVQQVVSNTDPDNRAGCALAFSQIYSHVGSLAAAPILKTVIDVLLSLAADPHPLVHYSALQALSHVIDAASLSYAPYTNSTLGVLCKLYMQDTHEPEGGTPGSVNLRGDLPAYQAMCRVLDAIVGVLGPELQDSERVREVVLVLLREFSLEQNDEGIAVEAIKATQHFLIFAPDALDHAELVARLRAQLSSPRQPLKVAAVNSVYQLVQRDAGLMSKLGGDGLVRELFALLDDDTTIEGVRDAILSWLRQTADTNPSGWIDLCQRIMSRSASADRPKEKAVVAGAVADEEVQGLGIADDNEARPGAPTARASSRWRTQLFALECLHEVFLTVLRSGRREHFDVAHARALRANKRGLLITRVSDLIKMAFTASTAQVMEIRLEGLVVLKDVIDNFGASQDIDFEDAPLLEQYQAPIAAALTPAFAADSYPEVIASAIQVCAVFVGSGVTKEIDKMGRILKLLTTALESCRDSDMTSLGDVKDLSSTAAVMLKTSILAAWARFQTASTRQPYLADVIRPHLPLLCPFWVASLREYARLRVDPTALSSDGSGFDSVYSGMSRETALPFYENAWPQILHAVAALLKTSEPFMVGAMHGAGIPDGQPTSLRRDDPSKPAMFFWTTFGIAYETLCRPAAVDTVSAGDIQSIALDALAGLLRREVAGSVISEEGIFEDVCDLLFRLSLTEGPAVKVRVLEIAVSLAPTVLAGDSTMNPRLKQCLQIATTVIRELLPATSSSASRVSAITLPAHAEHVRRAFTLYADLADLLPSQLRPEVYAIAFHLYSVLLKDEQSELDLASPTLPVLKMLTSRAFEGTGAADETLPRVLNGMLSACLLNFDAVRNRKSPAAIVKMRSNLLAVVLLVTSIPPSVSVGREVVDHACYLLAETAQEGDGEAQIAARNCVFSLLIAASRSSSGTLAFCAGRLLPSVIELVTRTASSKAPVSEAQLKAVDDALKACMAVLLSVPVERRTQSASILLPVLLDLVAPTSPATSARSIATNHLVSLATTCPSHFKEATAALESEQRSLLEDSIRTALGQGSKRNPATAGHAAEEAPRISLKMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHJ8</accession>
    <name>A0A2S5BHJ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phospholipid methyltransferase</fullName>
            <shortName evidence="14">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_0418</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="14"/>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHJ8"/>
    <dbReference type="STRING" id="741276.A0A2S5BHJ8"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="14">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="207"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY76223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="252" mass="28160" checksum="42E14794975EED36" modified="2018-07-18" version="1">MTALARYVNLSQKSLWVAVASILFNPLFWNIVARQEYRNKVLTRLAFNNPRWGCYGLAVTIFSLGILRDHLYQLALADQPKLPVLHYTEFKLLAAVLFAVGATLVVSSMWALGVTGTYLGDYFVRRHSHGRAFQWHGMVSRERLGRGSPEALILQHKVESFPFNVTSSPMYTGSTLSFLATALWYESPTGLLLSALVYAEYQIALSYEDPFTGAIYAKRDLDRSKGKAKQIDSPAAHVASTPASVGRPRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHK5</accession>
    <name>A0A2S5BHK5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHK5"/>
    <dbReference type="STRING" id="741276.A0A2S5BHK5"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="976"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="931"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1185" mass="125690" checksum="5BA6DB4839D0383C" modified="2018-07-18" version="1">MARGQSRGRGGNANGFRGGRGSRGGRGRGRGRGGGNALVVQDYSMAEFSYDDLISDETLGFNPSPAFQIPVLPTTNPYPTRSATQSGAATPTRGGPRGGSFAGRGNRGRGGSNSPASYPDSGRDSPSFGGGRGRGSGLGLGTFNARGRGRGGTASPRGAFIGSGPGRSSNPLLIPVKFVPAQGPGLGTVGGDDEHGLEKAGAEAPAPAPPATAHETQQHADSQLADQVGRIDLEQPAHDPSVPETAFEPEPETTATMALDELEDAPRAGPDETTRHPGLGSMRHATPAVPTEPIEQPLPTEQVETPVAATIEDEPPLFEISVTRSEVILDSRIAPPPALEAHRDDSFATSRDSEEDDDSDDEQIVYPVRAVTQADPVYSARPPQLQAQVPPPNIADFSTLPPEAARPPPAAQRASHPALPKQPAPRSKKALKRESRAARKAGRAHARSGNGHLGGGRTLADSDEDGSDDDEDANDAAAGAALFAQMQGGAVGVDDMLDVDEDEGEEDGPAGPHIDGQPRLDDSDVDWGSASPPPIGLGARSRGRAKKQYMRQQRADQRQAEKMERLIANGGTREEIELMLAIEASLRDAEGGPDVSEQKASKRRAQERQRLANDYLANLDLDTEGDDSMTILAAFANGAVGELGGTHERGDDLDRRAEEDEDNSDKWGTSDESGSDEDDSDSDEDTADAADRKLAREEENDSEEVTSSVELEMEYSLGDADGRVEHSMSLASSDSDSDDSSLSSSTDSDVELHAFETALLAGGKVKLSSMGQAGGGGRRAERDRKKERRRERKGKMRAAESSSNDDSEDAEMFGGNNTWADEDEEYIARLQNVVRANAELLETAKGGKDARRSNRRERNKLFKAISNGNFDDIDLYEDMDDLDDDMVAEMLAAEEDRSMGYGGPKKQRKKEKNYGGAFSASLAEQWELDRKSKAQKKAERAATRAAAREAETRDSFRDGRKAGKKARVTRDAASQSNDAATVNRQIVQFIKYDIGEMSMALPPMSKKSRIAVHMLAETYGLKSRSMGKGSARFPVLERTSRTTLKVNERKIVAIIGTADGEDELGGNYGARPRGGKMSGLWKALEGASGKRSGGGGGGRGGGGGIGRNNEGAVVGQGADKLGTENIGFALLKKMGWSEGGQIGLSGGLHEPVAARVKTNRQGLGSGFSVSMREAYGMARAPSRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIE6</accession>
    <name>A0A2S5BIE6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIE6"/>
    <dbReference type="STRING" id="741276.A0A2S5BIE6"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="185"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="611" mass="66554" checksum="05F5D6EDD071535B" modified="2018-07-18" version="1">MAALFSSLPAPLHTGGPADLHEDASAASSSRIQQQSTALAVQLPQIPPYGQRKGWKPKSQADFGDGGSYPECHCAQYPLELGRKKTAAGNTLALQVDADGNVNYGAIAEQGQRSGVHVQTSFKDLVPMAQRTDVSKDALAMERPSEEEVQATADRTKAALERLVQGKIKAAQPKNVEQRGGDVSYMRYTPQNGGVEKQKIIKMMEVVEDPLEPPRFKGKKVPRGPPSPPPPVLRSPPRKVTAQEQKEWMIPPCVSNWKNNKGYTIPLDKRLAADGRGLQDVQINDRFAQFSEALYVADRHARDEVRQRALMQQKIAQKEKEAKEENLRMLAQRAREERSGVVVQPAASMGGAGLGGALAGYGSGSDSEDEESAAIARGAQGQRAPSPGAASAFSDSEDEGAARGGGDDETEEERRAAKERDEMRRERRKEREREMRMSHMGTEQRAKVLAKATGRDISEKIALGLAKPTMSKDSMLDARLFNREQYSASFGDEDSYNLYDKPLFSGSSAAAAIYKPRGRNVDDEGYEVDQGEVEKAMKNDRFGLGVAGSGRGFDGADTSEIRDGPVAFERDTADPFGVDAFLESAKQGGAGDKKRGLDTGEDERRKRARDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIM4</accession>
    <name>A0A2S5BIM4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIM4"/>
    <dbReference type="OrthoDB" id="2588793at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="537" mass="61010" checksum="B4B27E64E02A2530" modified="2018-07-18" version="1">MSSTQTQVQTQPHTHTHARRRSRVSIHVLPETPEAEESEKPLLAGLSDRGSVSSGDHDRQPSQDSISLGHIDVLAPRPERRGFPWRVVLVFAVVTTICCVGTGAVVSHREGGRFERWAARVGSAPKPRRRACNPYHQFGVLNVSLSTPSENVWQPIAAAEDCQPTNYLEMLAQQHPSLPSKNPHLEFLRGRTILVYGDSIDRDHVDDVCGFVGGRHELIHDKHPLSPPYPLGQESPPPGYKNPITGERTWLQNGQSRPWICHIPQLDARIINVFHFGFQELSPWLENSPHYYPPATVEDRFDLIAVPLVKAFAQFHDTKPNPDLVSVAPGFWTLLRETIDKQQPYDQDIDDGVAFEDAHAEWRKSVWRTPSEHSRQFYEKRITQILRRVAAAWPETRSSRQPSLLWRAPHFVKETDRTPYNRLVALDQIGRSVVQRLTREGDAAQAGRAEWKRWRRSAAATGTSFDAADRSWARKAKLGERLRVDEWGARMLGQSQYFRDDIHPSPLPGSYLYGNMLFEHLRLFEEDRAAGTRPAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIU3</accession>
    <name>A0A2S5BIU3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIU3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="216" mass="23169" checksum="5088BE8BE4410AD4" modified="2018-07-18" version="1">MTPKPLRLGSSLPSWPLQTAEPASPSLLAPPSPATPRFPPQWNASPQAGMSRFVVPTPEARPSSQTASLVHASEASTPTSFHDHDARSEAVSFLDRHERPLLCHAHPHAGHTTAGYSRTPNARGDRSRSEAARPSTATDFSKSQSSRSAARGPVAMVNSVHAQRLTTDECQLPRQSGSRFSAYTAGCVQDLESLDDGAVVRYLDGPMDCTVHTPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ02</accession>
    <name>A0A2S5BJ02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ02"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="514" mass="55621" checksum="624195684E53CA15" modified="2018-07-18" version="1">MARPQVDETAHSSPALFADDARFANPDDFFAEATRRLVRDWGYVVERSTERPRKITGRCERFDQGCPFRLCAILPEGEPTWRINTNSCSWVHSHPARSSSGRFKPRPGAAADDSATNTASEPAGTSLTVVLFGDGTRFATSEAFFRQVNDTSKRLCGMGCTKHSETDTLLVARCTTRYRTRCRYKVHAVPAVSGGYILDAATSEWVHNHRRNSMPPFRESGTANREQRDKYSTALAPPMKPAQTRKFRSEMTHLGPQIGDRFRDFNEAFLAAASISIVTLGNSVARVAKNELAGGIYCHYGRGTEERCSYKLNVGRSADGKGCVVLATSHPVHSHGPCPELQADPTWRPNMRDRDLIRAVEAFRPAGTVKPKRTSSPVVEITFVSPKSKRLRLASDSAAAASASAPSPASSIYPSPTLSDSSLPSPQLGRPRLLTDPAAGVPLVDRIALVEAFLAGVDPAQTELAPHLVAAGVDSLEALVGFATLTPALRQGLLDELERRGGTGLARLGGSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ35</accession>
    <name>A0A2S5BJ35_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0019</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ35"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ35"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF20">
        <property type="entry name" value="HIGH OSMOLARITY SIGNALING PROTEIN SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="12">
        <location>
            <begin position="287"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="297"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY76770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="356" mass="36990" checksum="8B041905EFF7C123" modified="2018-07-18" version="1">MPSRSAFDVRMPLAHPLFLITQLAATAGFWTAFIGQIILESKCAFKPGGREMDGEMHATGRTDTNHKMAEGQQSACLGSVSRCRRVQTTKNVADRGVYAPLERTGIFLQAFLNIGVFVTLATDNVGANRFQLSVFLAVALVMATIGVNLGIFQSASYSLAVGAGWIIIAVVDILWILYFTSTDDAWFVALFDIGSTVHFSSRTSAAGAGFAGSSSSIVRRTGSGAAASAMGMAGPSGTGVSYASYHGLGGPNAAKGPGSVAGMGSHLGPAQASVADLHEGASPNVQSDAASSIGTGAANLKARALYSYSASPDDPNEISFTKGEILDILDNSGKWWQARKADGSKGIVPSNYLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ39</accession>
    <name>A0A2S5BJ39_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_0031</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ39"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ39"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 14 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="842"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY76782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1037" mass="116867" checksum="56D378BF9E0015F3" modified="2018-07-18" version="1">MASVPSSGINVPAGQQIRFRSNRAAPNSSGAGTTKLQPSPNARALRPVEPGLIKDPNLRYAFARWQPTVLVAFRFLILIRFCSAMYTAIGDCDEVFNYWEPLHYLVNGKGFQTWEYSPVYAIRSYFYLLIHSGPAVTLKTLGFPDKRVAFFATRLMLAAFSSYVEAVFYRACAVHVSSHVGRYVLWLEMFSAGLYSASTAFLPSSFAMYFVMLGLSASLTPVGGGWKRITFATTMYAIAGIVGWPFSVLLGVPLVLEQLFVRGTVQKVPAGLTARWSMLRARNFGIALICGASIAIPVVMVDSAAYQKLVIVPLNLIKYNLFPVPGAGPDLYGTEPWYFYLLNALANFNILLPLALLSLPFLLVTLAVDKKRFGDARDIATMQTHPATSLAIRLVPFHLYLAVLTLQKHKEERFLYPAYGHLILNAAVSLYLVRGWFEAAFLKVTSSPYRATRTSVFSHFTRAVIVSTGLISFARISALHNYYHAPFNVFHDLQLYELPRLALTIQPELAPKVDTTLPHDAFVKAIDLDQALPLDGLAPLNLRLCIGKEWHRYPSSWQVPDEVEPRFVRSAFDGILPKEWEAPGEGKGLFGRATATIPTGMNMFNREEVDRYVDVSTCDYLVDVDFPDREVNIHSELEPRYALDSEHWDRAFCHRFLDAANSPRLTRAIKLPLPGWADRNSWGEYCLLRRKGLFKESRAKLLALASLDDIASTLYHAEWVAGRPADLLRPLRPPIIRHLLGISHLSDCKQLSENDVKRLCDKAREVLIEESNVQPVRCPVTVCGDIHGQFHDLSELFRIGGNSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRDRVTILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALIDDQIFCLHGGLSPSIDTLDHIRSIDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLVARAHQLVMEGFNWSHDRNVVTIFSAPNYCYRCGNQAAIMEIDENMKYTFLQFDPAPRAGEPLVSRRVPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ45</accession>
    <name>A0A2S5BJ45_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BJ45"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="146"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="491"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="1031"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1302"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1306"/>
            <end position="1323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1384" mass="149859" checksum="2E08209C84F17D29" modified="2018-07-18" version="1">MPAPVPNRGAACVVVLGVGLVVASSATAYARALVALYAVVALLARLLRYALLIAVAPLAIAWLVERRQRQAAPGNSSGPCGEAERPTSLASAHTRRRKAVQPLYFTSPAAWSVTQTRANWEATARSGPRPLLPTSTLHSAARPGTAAVFDTALDSLLQLVTRDFIQKWYSSLSDSPVFPVAVESTIRDVLVAVAARTAKLDWAEILVSRIAPLLSTHLERCRAAEKAVHGRDAGKAPPPDSDEADLLLAGKYAAATSSKKLHPAVDVASPNSRPAEEAWLRGLVESILPLVLPEHEHASPAVRIMIREIVACAVLIPVFETLCDPDFWNRLIEDKASAAIRDQRMVSQFRQALDEGAAVASAGKRSFTAPGKIETEPERKRSLEVISVRTSGRQFDAWLKGISRCATVADAKRLRSDVSAQIRRAKTLTEGRKSDELVEGIPVSQWVDFIERLYTAKRKIDKRISKLGGDSAGFARAPSIYHLAAAETTISFRDILLDPSAVTYAMEYLERRKHASRAVFWLAVEGTKDPLDDIVDDDLVVTTSKTAELQTRAFLDDVKMIWQAYLATDPFGSNPAHLQTIKAFVAATDTATAEITPIDLRTLRHALFAVQHGVLALLQEEDLPGFVRSDLYFKALSSLLPASNTASDPAAPVEEPSIPVPTSPRAPTAWIAVGASTTRSAPALPARPEVARLEATRVLATSEQSKAADPSKVDSRRSPSPSPSPVIARTELLVARETAPPQVSRTHAVIGEQVPTVDGETTPPSLGPPRAGRLPSLSRIDESGVDERQNPLEFLIGSPVDDAEDAPRPPLFEGAEVDDVDLDDEDFVEIRTIDAIQDALSSILESADAQSARSLQSSVTSLPDRVGAPIGRRISGDHVRSKSASALTTLASAAGSTSSGSPKLPLSPTVPSVGLPALPPVRAQRVFDDPETYADPYDSAPNNQSSAAASILMSASLSELEERTSTLHEQELVVDALIRRAELTGNVAELKLLSKSRGMLENELRAITYRLAQLETETEKDKTAFSAQRTRLSIPGTSVGQVSGLGSQSFQLFLVRVQQQTSDASSVEWIVPRRYSEFASLNDRLREQYAATRALDFPTKRLVGTWSKEFIEHRRLGLERYLQELLLLPEVSSDASFCDFLLRQSIAVPSPDVRQKKAGGAATPALVRNLYRGFTAGIDDVLGTSTTSLLDTVVDRLTAQASDLAEQASLGLRVDDLTAGFPNAVAAGSTRGEGLSSFTAPICDLFLTAFDLREDWVRRQAILIVLQQVLGSTIERKLRDTVATLLSPPRLAGYLDGLRASLWPDGQKRPPSEPRSKDQRTDTRNAAISCLSTLMPEFAANLIGRHNAKWGARRLFAAVQSKRLNKHLLYSIVDEVLHLVFPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZL0</accession>
    <name>A0A2S5AZL0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_7013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZL0"/>
    <dbReference type="OrthoDB" id="2533906at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY69969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="960" mass="106024" checksum="E2E91786B590E128" modified="2018-07-18" version="1">MTENRARHWPRSTRTRYRAIRPRSVWIVHGPSAAMSYDSGIQRYEPAYRHDDRRAEYAPPTTAIGSTHAYYSHAEAPYAVAHAHEERQYAPPYPRHYADHVREPEATRYGTEAAAFGNEQRYTTYPQQEQAWPTYKYAPHVVSHYAPAPDARPDLNQDEYSADPHRSAFPVLTSSSTPHQPRPPSVTHSAASWDYSQRPYAAPYAAETEQIGTVEDGRSYSLARNSGSNSAETALAAAHDYARAGEGAIAYPPVSDAYVQHVPDRRTYQEIPLSPPRFPMNVPPRRASLDGPPPVYCAPEQPEETYASTYDPLGPISAPYRQPDIQPAAPPTPLSFQHYPQRPALQPARLSISHASDREPSSTLATLQEAFRERAMHNSSAPILAFNPAREPSASGKQLVETDFGVTYAVAGSGQSKGKVKSAEVIVACKTCDVTRVKCIMRGADLGGWMPCVNFKCLDCLPPEAYSHDAAASEARDERLAARAFEEFQQSSTSSSAPSLQSVSPPPPPQQHEHDSVTFRDTFSGAVDEIVRSQTTPAFGTSSLPLDDSHRSAAYPQSRLLLAPEETARGLSASFKRQALCCDVCSRIVGAGSIESLSAGPAPAFTVESICRSCLERYRPCSDCGGGGGRLTPGRWRCKGGRAPSVTRATRPWQTSTTLTFNLPTHSDVLRITEIDPSKLASLDDQLRKIYYNVRMRMQARPEMLERGDGLATTFAQVEKLIIDGWTLLRPLLFDDVEASRGLRRYVALQTSTPHKRRAKPKPGALPKPEPVVPKVDPVERQVSGFLLLEHELATGAIHVAVTMPWAISGDAFDATTILLDETLKRLRRDLAYDNAYRAKVSGGRDPPLPDPTYLWGITPFKSDSRMTQSLTRRGFHFVEDRLREDPNFDTSIFPPSRTVHVPNEFMRSFRIFLRDVTEDDGRISGVGADAAPRKRAGSGDGTGKPPPKKRARHLKAKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZL4</accession>
    <name>A0A2S5AZL4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_7020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZL4"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY69976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="208" mass="22948" checksum="2B98A50275325784" modified="2018-07-18" version="1">MAISIQPATRDDIEALSRLQLDAMSSDYAWRQIFRDADADDNLRLAIKQNLDMLTRSGRSLTRAIRGQDDEPIAMALDALYDAANDEPGPEPELPAGANTRLAEAFFPIFDDCLKYAKERDGRFYHLTVLAVAPRVQRSGAGKALLQAFVDKADAANLPCYLESTEAGQGLYAKYGFVPYRGVARCTLDEEMSVLPMRRPAKSEVGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZQ1</accession>
    <name>A0A2S5AZQ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CxC5 like cysteine cluster associated with KDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_7029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZQ1"/>
    <dbReference type="STRING" id="741276.A0A2S5AZQ1"/>
    <dbReference type="OrthoDB" id="2527272at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041539">
        <property type="entry name" value="CxC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040898">
        <property type="entry name" value="CxC6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18718">
        <property type="entry name" value="CxC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18721">
        <property type="entry name" value="CxC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC5 like cysteine cluster associated with KDZ" evidence="2">
        <location>
            <begin position="323"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="CxC6 like cysteine cluster associated with KDZ" evidence="3">
        <location>
            <begin position="601"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY69985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="102609" checksum="80CF30379D024575" modified="2018-07-18" version="1">MADDKEHDEVLISRLRALGYSIALPEVADAGETSEEEDRTEAWIRTQANRGQPDSRTTLLDRFLASTRDEIDSVETTNSPSATADPAPASALTPDDSLAGLLRLIDEHREAALAGKQAKAQQKWASRSLAAGILLSPTKRVRQRPPSVPASSSSLSAASESGSESSSPATPCPSERPPGNNSRPKPPSSPTPRKPRLGSGRLAGVAALAIVTPRSFAAATPSSHFALAAGHIGELLPDASLVDVLQLGRALEQNRALLSLAQQQADSGGRRFGSNLSFLGSHVFSSSPLTPSDAGHAALRLAKALRLDLPDDPTSSATNDSAVQVLTTPAAACVQCDSALTLRRRPTEPVWLVRPAQPAEKVLIAIHACTNPACSAIHAPDHVEISHQKRTAWLWHEQPVAFKVGERAWITTEGANHVRSLVLEQAVSPGGFASMWNRLYAEESHEPSASGDEDESDIDDEDSSERMPDRSPRKSASAGPSPRKRPRHSTFQLRAAHVWRAFVLTTCLYEGHRASTNRFATTCRPPTRVLVDFANTWLFPHVLSEHTCSTCTRPRQRWLGGPATAAERRGGLLWAGTRLYEGLPLVEDVESTEGPPVQMAVCDGVAMGYSLCASPNCDNSPRRNRRSDRFCEDHLYLHGRCGVVGCDSKRTTHDSASGSSEACDEPRHQELWHDFLRRSDVRRNRGRGRRAGEHRLVVDDVEAVSAADGSGDATEADSEYDDSGDAKTRRTAQTMWAMRRTSNLQLLVAACGAPLAWTSFVDGEDPAAVLEFLGAVHADYAARGASMPSYIAYDRACQILRQVLGDLVDDDDAPSLPPLLDRTRLIVDAFHHRCHGRDDSFCATFCHPAPLDGSAPDLVIPLRTDGVPSNRRKDRHRTVPAAGATAVRVERQGGRMFERAFNTSAAEQLNSHLSRFSVLLGGMRAANLDFLVHALLRNRRDLLRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZS2</accession>
    <name>A0A2S5AZS2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vesicular-fusion protein SEC17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000153">
        <property type="protein sequence ID" value="POY70024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZS2"/>
    <dbReference type="STRING" id="741276.A0A2S5AZS2"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34492" checksum="A1B33F39A9631C06" modified="2018-07-18" version="1">MSSQGDQYRQKADKKASSSGGFAFFSSSSSKFEEAHDLYQQAGNAYKMENKHKEAGDAFSRAAEMALKNDEKDDAANDFWTASKSYKKSHPERETLTLRLKLAVAVASLQKTIQLYKEKGRFRQAADRHKEIAAILQQEGGDLAGALEAFQAAGDIYTQEDATASANGCYKEAAELAGSLGHYQRAIELFERVASQSLGSALTRYGVKEYYLKAGLCWLATGRSELTISRVAGWKQDVVSTKRAIDNYCNADPSFATQRECKFLNAIADAFDAGDAEEFTAAVADYDRLTHLDAWKTGLLLAIKRNIAEEPGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZY8</accession>
    <name>A0A2S5AZY8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000147">
        <property type="protein sequence ID" value="POY70089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZY8"/>
    <dbReference type="STRING" id="741276.A0A2S5AZY8"/>
    <dbReference type="OrthoDB" id="10618798at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="1">
        <location>
            <begin position="67"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="394" mass="42359" checksum="F8FE79BB2688DC3D" modified="2018-07-18" version="1">MLPCFSSIKVSPFSRCCSLGVAEPAMLSFGRRVIQPLLAPAFFRSFTQARPSLATLGLLSSPHQADKLPLVPKDVRNIVWAGHQVLLSQGATSCLKEAYQAAGARIVQEADLTACDVLATLDRLPIINESPVRSEIRVSRRAKTLRPSSENPAVVERPESINTAALASDFAVRDGTITTCIAMQLGRHAMQQALDGLQERLARLGAKGRVDTLAGKPEQVLRKIKKGKSIIIAVMGDTGAAHGACAVLNERHNVKWIPAKHLRRYAAGSGHSPKVYACLLKPADYLVGPNGSPFDQRLYAERPECFTSTFDKRVAPFITLLVHAAYPNPRAPSLLGSDAAESVSRARKPAMIMAVGIEAGIQLGTMPLAVPASLVQALRTSSAFKAPYGDMKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B027</accession>
    <name>A0A2S5B027_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B027"/>
    <dbReference type="STRING" id="741276.A0A2S5B027"/>
    <dbReference type="OrthoDB" id="3232309at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="48704" checksum="0CF28BA7120DA73A" modified="2018-07-18" version="1">MSTLAVPSSAPASVDSRDHRNLRTPPPGPASSRPIRHKFTYPVWNLIKVPVRILKPPKATGMVGSVRSLKATPLMDVRLDDVIANKHLSPLSLKDFEGYLVYREYSAENLYFILWLNEYEKEYAAYLKDPSAKREKVDSSVEASTAPMASRTASHLPEYLATSLRRGLDSFFAPDGPLELNLPRATRDKVLVEAGASGDPKDFAAAREIVEQSLARSLSAHARSSVANAGPRRLVFCFSLGLFVFLAGLVPPLVAIGTNHARGYRVIGLPFIMLGVAIMVMALNRICAVIWLLGEDRQLLPYELAPPTVMSGSIVPIKCPATPRSSTSDSWDEESTYGASDYSSEDDKADTSFRTQTSANPYPWEKDDANPATAQVGYAPSAPSSRPPSYRSGGTSSRGVVPDSAPVWGPVTAVFSPDVARAQWRLAAYALVIGAVALCTIGVVLMAVPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B058</accession>
    <name>A0A2S5B058_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B058"/>
    <dbReference type="STRING" id="741276.A0A2S5B058"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="874"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1250" mass="134559" checksum="061C828A861C78C9" modified="2018-07-18" version="1">MSGDAEDPPQSFSSLRARFEQLATTPPAAPPKPAPKPAAALARPAPAPKPTQLAQKLQSDDGAEQERGPAPAGAVASGADREVQNGNLGPAELEPGSRSATLSRDSNSSRGAVEDGDGEEGGDPFGENAGTADERTDTTASVPAPPALPLEETRAGVVEENQIDRPDLSRSQGSIRRPPPPRPAATATRMSQDKATEAPTLEQEEGTSVTHARSELSTPDTATVNSASPATSVRSLVSRFAGAPDMIGMRSNSAPALNVATNLRLRSDISAPGSQSVPLSPFETGDALSNDGYSSDSTYHSSSDDEGPEPEKASVDAVGRPIIPPRPAIHEHPPTPAPINITMPALPNRPRRAASPLSPTVSVATGPTPQDQALSIPFTRSPSNSISVSADGPAGLPPIPARPLPPARDQATRFPPSRAEGVAPALPAREHPAPAVPLPPRPAVSAPPAPELSAIAAATTAYVPPPPPMRTAVAAEKWPPKRPSMQNGSGAGDGSSEGEGDDIAPGQEFPDATFANRRPPTLRTRRPVQTTNQFSAWTARGSRVVTAHHRLHLWYSSSSGVTSQSIPICNDQQKFLSVAWRAADADRPEDEGRYLWCGTKEGHLFEVDVEQLTVTEARQHAHSYPVTSIYRHGRSMITVDESGKVLVWSENGGLAGSLAVAATAQQRLPAQQTWMSLLGDELWTSSGPTSKPGSTAVSMRSPQIRIFDPTGSRGGAFSLLNRPLVTPESAGYVGAVSASAIVPEQDHLVFLGHDNGFISVWDRSTYSCAQVQRVAAGCVSALIGVRNSLWAGFRTGYIHVYDVSADPWVVLKAWKAHEDPVIRMMVDATSLWQDATLQVASASNESVCLWDGFLREDWIDAELHLRQPDYCTFRSIRALCVTWNVDSNRPADLQGSVDNLEFLRNVVTSVDSPDIISFGFQEMIDLEDKKLTAKSMLIGKKKAVDGKMSDSLSASYRQWHDKLVQAVRMHLPADTPYTVVHVGDMIGLFSCILVKTSEATRLRDSALVTVKTGMGGRYGNKGAILSRFVIDDSSLCFVNCHLAAGQSHRRQRDRDVADILESKASFSQLASSSPGAYAPGGAGTMVFDHELTIFSGDLNYRIDARRDTVVSAVATGNAESLLQHDQLLKNLANNQSFRLRSFKEAPIRFPPTYKYDPGTDQYDSSPKRRIPAWCDRILWRADRGDDVSPLHYQRYEVNVSDHKPVSAAFDIRIKRIDSNKRATVWQEVESAWFSVESSILESARRYYGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0A9</accession>
    <name>A0A2S5B0A9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B0A9"/>
    <dbReference type="OrthoDB" id="5597783at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="1184"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1431" mass="149235" checksum="6A01BD5263148593" modified="2018-07-18" version="1">MTGSAEGASGRVATRQQRSIAARENGVGSTGATAGSAIATPAHAPRTRSRAGSLSKPPPTLAKAVRSHANRVTATPPPTTSAPPVTPQQQQLSQQNGDLIGSASASPGRTRSRAATATAGPAAAPIESGAGTPLSAAAAPANGSTMPEKEKHNTRFAQQRRPAAAHSAQAAAASSAAATPAVVYPTPANAPPGYRPASAKPPLTRVPTFPLVEAYVPDSDPSNRRHPRQLLPDDLGFPTAEMKGRIKRDDLDDKLLMATCAVLHAFENRALCPKEVAEVMLERDWLKNAGTTPFAHVSTCIRSHVARASQATPAYEPLLVPFELVGALTPEEVRAVGLHAEQRPAVKRGTLWYLNPRVLGFGIGADDPFVRCRREAGLAPSDRDGLYARGLVPLQHAAPALPPALTLSSTLFTNTQESAVGSPDEGDFDEEGMGRGKRKRRASSAMMAAMGREGAKGSVPSPLGSGSSTPVPIPAAPASILVNDSASPLPTFSHRRSQSTGGPASAPARSGLPKLKFRLSSLEEVEDSDGHTGEAAQWRKKNKKKTRRAGSEGVSRAGSVESSVADDGLDEARALAFSSASSSALLAQSLLAASTIDSSTVGDSQVAPHSTISPDILSLGPASTVAFPFSRPSSTAFHLSASAPNIFSHHFTSAPSPPDVLMDDSTSDLSRPNTAAGVDGRSLAGPADAAASPASDSPDDNEDDFHEAMLRGDDFDFEWGYDSFSTNGTSSLEASAVAADLLAKAFEGHSDEVDGTPRGKAHELSAGTVGGEEDEAAVDTPATTPRSLPQDSDDECSKDEMKEEKLAALPKKSSIEPLREPISRVGMSITLCDAMSGMDEAEDRDAVIVKLEPSMPEDSNEARDPYAVPNSPVPIEDARHRLDHVQIPAPPPSPLSLELTPTIALSNAFAATDYDFVGRDEAEGLEGDVTSPSYAYTFEADDEAGENEYDLDAEEILHVKSEDEEAEMAVSSAPSSRAGSSAPALFDVRLLASVRAASVASSSSESDTLDPMSFVSPSTLATGLPVPQAAPSPPETNDWTISLDMLDDLDLDASAADLLGPENIGLEELDLAWAGDEESLPVEHTSKPSVVGGMPFQPTRPGATFLTGSTNRFTSPMPSPRRLLSSRLPSLSNDGFLPAPAPPTTPAAGMPTTAFGDLEASTSSPLSLEAVIPLEPSVVAKIVQRGIVVFSTDVSDLATGQPAPLLRRLDTDYVNATVLLQAALSSPLERASALATLLVKTDTFRVPSGSGDPGVEGTWIPLAAAEDVVATYPEQLGHLSAFFGADLAALFPEPVPTMRNSSREPPTAKRGDPNAAVLGTPSFAGAELLRRCGPPFAPRELALFVHDDEPAANVAQQGADGAGHDADDDGDESTEEEVVAVEEDTVEAAESTPASRPKRESRTRRGTAAKVKAVEHSPPRRSTRRQSMAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0G8</accession>
    <name>A0A2S5B0G8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000137">
        <property type="protein sequence ID" value="POY70277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0G8"/>
    <dbReference type="OrthoDB" id="10690766at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="940" mass="101748" checksum="FAF3E4A4E22B2E4E" modified="2018-07-18" version="1" fragment="single">MTVSDQIVLITSDECKLLAHAKNELSEPSTIFSMSLASPLSTPLAPSLTFTSSKARLVVALLPPVDHTTSDTPETTDANSQVSNKREEEAAAESELDVPMEDSLPSSALVLPAQPATDFLSGDPIRSRLGRHLDILRALVDDAGDRARARGQLRASSSSDARGLLETLDRRLRLSAFHPETLSGNQSILERFTGTPETVSFLTAVTRDPFVLPISGGTALTPIAYDLFSTHLPIDEHFPKRSQSMSRYLRLVIMPDEPTTTAYLMLHGQLFPADSPKLRAIRSALDARTAHKSEPVALKYFGQTERTTPLGRAQDDQNASQSFVKNVIAVLKALILSEPIDATMGFDWGKVQFVLHEFADLEQTSDGPIDISDFAVGGVEIALITSASAGLNSAIGGFRPTLDRSSFGDICSLMQKHDADLSRVRQLLPVAGASPTRAEKIAAAAVDSLQFWQTRPEESGYTLDDSTESGTRVFQTVLEAMQAVKCLASDPGGPTLELLVMKDVPKADLLDLQTSHGPRAGRGPHLGFLVDSSVLGASIGTWTAIAPMTNLWQWQLRHLKVGWAICFLIRYICCVDPLLLRVFSGKMSHLFRSSLICGALDTSAPGLDDFLACASSTTEASLEAILSKSCVLVWRELAPSNHMRDAGKTSVVQWGPHASNLSIIFAELDPGFHKYDPSVSDLVVDLVQLTAAKAAFAREALGRLLAFEYGATGAPAAAAPRREFLREARRRCEARSVAMGLEARLLRARDELATAFGALNAARQLSAGDRRLADDEDRKRERRSESAHLGVANRAAQLEFLGPPLPAPVMSVLELHYSAPDDGFLSPKLLSLTSYPVLGDPLDPATLWPRLVQLVDLLAEHTEATLDGLESPVSALPTTGAPVASREWVGWFCRAPEGVEVARSASKAGWAGERDWDAEARALQSEQQRAREEQKRASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0P0</accession>
    <name>A0A2S5B0P0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0P0"/>
    <dbReference type="STRING" id="741276.A0A2S5B0P0"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12372">
        <property type="entry name" value="RRM_CFIm68_CFIm59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="49315" checksum="D6679CA19BBBF789" modified="2018-07-18" version="1">MSSDRQRQDRAGSLELDYGDDMADLDYDQWSAAQVAAQNDAAHAQAQPIASTSTSTARTTSESKPATTATAATASARPLPAGNGLPVNPLTGQRPTIAMPAPSTSSATGASAGPPSSSTSGVQQGTLAHTAVFVGEMHWWTSDRDVVELTQLAGIHGVSVKDVSFAEHKVNGKSKGVCYVECHSQENAQRVKTYVENNEFQLKKMTATLAPGGASTAPFRTLPKEPSRGGAPAPVPSGQVRIGNLTVRTPRPATTAYLEPHVGQNRRDQPPGTGPGAQLGGIRLGGFMPAPGTAGPGSYGQKGAGSNYHQQQQQQQNGGAGSAGPPLHMGMGMGLPMNPMLAQQQQQQQPNQQGGVFNPAFMNAAGGGNQAAAGGVGGGGFAFDPSAAFGMANFGMQMGMPGMGMGMPGMGAGGGAGGMPDFSQQMNMMGMGMGGMWPFAGMSPFGAGTAGGMSPMYNMSGQGDGGGGAGEGYETGGAKKRSRMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0V2</accession>
    <name>A0A2S5B0V2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar import/degradation Vid27 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000118">
        <property type="protein sequence ID" value="POY70409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0V2"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="293"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="508"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="94772" checksum="A28ECEC05F9DF4D8" modified="2018-07-18" version="1">MYQLVVTRAFEEGEEQLLDEDAENSDERSFLLDSSLFLSLGATLDPASASSGPNGHPPLSFTWLDPDGDGPDDEFEFVLPADGSISETQARDFEKLCWRCMWERKESREWPTDSGEAKRADARLADEFKVERAPPPAPSTPLYPNLPTASSSGASTPSRLSATSAAGSPLRTTQVPGAMAGKTPLFRANSPDADSDDDEDEHEAARADQYDDGDDGTPYQPASAEDDDSGDGLAQQLMQKATLSPPVPSTTSPSRGKGKGKAIEATRAVPVEDDIAPAMQKPPTPPAPPPNEAVIAVQASLHLYDRATGLFMLQDDSVKAGLYKVPPPNSGHWLVVESDKEGDVWVSQAVTAATTVNFAEKERAMVFNYTAPAADESSAPETYTWLLRLPDEDGFTALQAAVSAALFEDKWGAGSWNKMKDDDREYARKAWLEEDVEMWDVPEEEEEEDAEAEDDDEEDESDDEDEPLAVGDDEDNTDDDDVAAPSAAKAFSSKPPKRLPIGAKKRAKNSALAVGYKDDLSFVVQGDMIGVFKQQRDGGKKLKFMTSIVNIATPDQKKGFAPGKVMLHNQDTSMILQNPLAPGSLYRLDLETGKVVDEYKVSEDFAVQNFLPDAKFAQTTQQQTFIGHSHNGLFRIDPRLAGTKLVNSEFKQYATKADFSAAATTEAGKLVVGSAKGDLRLFDKLGKNAKTALPALGDPIIGVDVSADGRWILATCKTYLLLIDTMIPETSGSKYAGQSGFDRSFPAAEKPTPRRLTLKPEHIAHMQEVQGGDGVSFTPAKFNAGLSGEPERTIVTSTGPFIVAWNFRQVKSGNTNNYTLRRFSEEIVADNFKFGGDREIIVTLPENVFVEEKKKLKAPTRDSIVRTWDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B118</accession>
    <name>A0A2S5B118_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B118"/>
    <dbReference type="STRING" id="741276.A0A2S5B118"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015472704" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="219"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="280" mass="27691" checksum="D9872CBAC6584106" modified="2018-07-18" version="1">MRFFRNCAVLPLLFAGAMAQIISIPGLDIGLLQDGALISIGAFANLLGGGSCSAGSTLAVSTTLIGLVRICACVNVLELGPVLGIFGAVLGSNDACPPCPANAQAVCGAGKCACQCASGFYAGPDGTCLPASSCPSPNTVNPTLNVCVCVAGFVSDGAGACIAIGASGRARSRRHHQRRDFGKAGHLAGQQVYAPATAGAASASCPRGETACPLASGGFECVDTTNSLTACGGCPSPNGPGEDCLAIPGALNVQCADSKCIVGSCFKGWHFNASGNGRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B175</accession>
    <name>A0A2S5B175_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B175"/>
    <dbReference type="OrthoDB" id="2527629at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="173" mass="18272" checksum="20B658FDD28A8F21" modified="2018-07-18" version="1">MPAFAGLQLLTYGLGCIYSGWRLCNDPTGFLQQLAPVLDRLEHLAKSKAGITLARVHASSFQSPGLAFAGLLLMALGYMHCMTVYTLDEKAKRNSTSGRLILAAGAYWLCQQTPHGSSLMALFGIINLVSGLAMGLSVGFGDGNAVDLEIKERIEARKRAAAAAAKAQPSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1A4</accession>
    <name>A0A2S5B1A4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1A4"/>
    <dbReference type="OrthoDB" id="2530179at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015621789" evidence="3">
        <location>
            <begin position="32"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="435" mass="44586" checksum="625239F3837AB87B" modified="2018-07-18" version="1">MLSIRRFARRDPRRAFLAGFALMAFFAQAVAAVDSTISITTQQRIQVGDAVKFQQGGKPPYTLKVLLNNSVVAQNEGWTGTSVQWRATPEQLPAGTEIKIRITDSRGEMVLSDATKVMAAGASGSDNADGGKDRQSQQQHQAQHTDGEGERDGAVRSGNAQHMDDPTGSGAHGDEGEDDLEALPAVPPRGPGNDIGGERSSEGLDSGSSSMMTGIDHAGAVAMPTAAEAMSSPSAPAGSSVSQDSASGALPTSNAALSGSSSTATTSTPATSASDASAAAASSSAVSDSTDSSESGASNKTLYIGIGVVVVLLAGAGLAFFFWRRNKQQSDEEEEAQEKKATRKRKGKGKASSRGGTAGGAATDSQGDDEEKLVGGSDAGHDAYGSEGSDEEAPRTSSKKGSARRSGRSSQVYHDDDGASEGLESDDRAPPRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1B5</accession>
    <name>A0A2S5B1B5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1B5"/>
    <dbReference type="STRING" id="741276.A0A2S5B1B5"/>
    <dbReference type="OrthoDB" id="10373218at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="696" mass="77124" checksum="6EF9C5C36ADD89A5" modified="2018-07-18" version="1">MATGRSGMGAGRSMNTPVDVRTATERPPSEPARDPPRHRSHAPSPFLSPRSSAKHAQKARSNVYAPRHAREPAPSVEPERGRLAGKLHKIEEDEPGGRNALDAQVIASLFGTDSEEEEDEMEREQNLRRTGQSESLPTMPLHRTRPHLDARYREVSHDTTLSDLAPVAGPSGLRRRAGQAASGSVGPASSEDEREESSRPLRTGRASRTSRHRDIYSAFSTEEESDESQTPMPIKNKRFIQRDESTGARKRRHLGGTKKKSTDEQVDSFLSGLDLPEPKYRPLSVKARLANELADRTSTLPPRFRVDHVTLADEHEDGDRARDYRYSDDEGAEDGPSGAVAGATAGGYATPSLAEERAASPADSIPDYEDQEPPETALAPKYDEVEQLDEQPYFTHPTRQGAVERWSGLLDTRAQDLPVGFSYQAYLDDLAEVKKLERSRPHHGTQPVPIKSGTYIPSRDFQLDPARKLLSLRPSDAVNAALWESLLSPTHSEDHAHVPGQGRKCTCPLWVPSSCPSFEVEVKTLSQKRGLGLADLAEVVEAVFPPPATCQEPREALLRRIYESNWLWLAGIEELASIRKLYVQLATESLVEAVALAVQAQFEQDRIQLKRVELELARHEAVPGADIQKALELSRQVALKRWETEDRHAKSLSRLDRLRQVSEHKAPAPLPSGKDAARAAVEAWRKPVEAPRPLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1L7</accession>
    <name>A0A2S5B1L7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1L7"/>
    <dbReference type="STRING" id="741276.A0A2S5B1L7"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="351"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="728"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="841" mass="90041" checksum="53521BC20D5CAFA3" modified="2018-07-18" version="1">MNFSSMLNPTGTGQPGQGQLNGNASASAAAADPVASSSRMSFAFLDAPDSRPMTPMFSHAGPMPSAGPYNVAPPNAFQLHPSAQHYQHFMAPPQPHHFNPYGGFDPRLLGVQPQMLVNPAALMQQPPPMVMESPDANGVIADSDDDSARSVYAQGSTPRAVKQEDEVEVDIMGAGNEVVAVSALKAQAKASPAPKPRSKGSQSKGKSRSAQLASSAAGSPAPSPGPSSLANEVVPGASPAPSAVVEEESPAAPEAPDYSFLPDIAPSDYHHPRLDPSVPRPRLPAAFEAYVPPRRSRFGPGQDDSSSSDDDGEDAKRREQKRKAQAAAARERRLRAAKGNGGGPEEEEDDRLYCVCHTLYNPERIMIACDRCEEWYHLDCVRISEESVELVDLFICPKCASNSGEETTWKNCCKRPTCQHPAAPLSKYCSDYCGISVAAARLSLYEVDAEISPAMFWDKVKAATRREGEVVEAGSDSDAAARQAKNFARQDAADARLRGRIESRLAESNHRRAGLEAAVRLVEYRLAYLRIAIRRWEALCQATADEMASAGIDLEEVAGQNAKSSGGGGGRKNRGKRSGASKKKGPVAATSLPDAQCGFDVRLVFDNKDWQATVDSPGVQAMLAAQREGEDAHLLELALGDLDGVCLETKKRCDRHTGWQKIREADFAVEKAVLDRRIERVGVLVESLAARLEQHDTTVAFRLANRARTCDPARLIDVEDFMIDREEELDEEREDRDARDERSPSLHANGADTPKGPRGGGGGNKGGGRTASAAARAPPQGRTPTAAAARSRAPSTSQESTPVPVSAPPFRSMYDELPDMVKACCSRAAAARLKATPATGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1L8</accession>
    <name>A0A2S5B1L8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000105">
        <property type="protein sequence ID" value="POY70679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1L8"/>
    <dbReference type="STRING" id="741276.A0A2S5B1L8"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="113"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="501" mass="53994" checksum="1B1897A9D1E6D570" modified="2018-07-18" version="1">MPKAPKRKGKLATALAGQQLAQQQRQAEERARQAQEDRDKAKALKANASRSKSSASSVSSTATPHSAVATDAPASSKGKKRARQDDVDDNEETAERPRQDGGVQPFKKGERILLVGEGESLVISCNFSFAHALLGPSNSPTTEPSSSASASPKPPTPGQPLVTPSLLLCTAFDSEPVAAQKYPDLSVHVDALRSAGATVLFGVDATNLATSKQVREFAAFGPNGPVRGAKKKERRRVKGKGRMLDGWASRADKLEKDARMLDGDDDLDEDRQVGFDKIVFNFPHVGQGITDQARNVRANQTLLLDFYRSAAPFLRTGKPHSLSTASASARRTQVHRHAGSDSEGELDLLDEQAGPDAESGLLGDASMQAGITTAPTAGTGVGAVMGPLPPHRGTILLTLRTNGPYASWLPAQLATKPSLLLPSILPVHELKLRSTPQRGGPQPPYRTVRSWKFDTKRWEELGYEHRRTVGYEEKFAELDGGKNADLAMTAKERKQRRLEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1N0</accession>
    <name>A0A2S5B1N0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000104">
        <property type="protein sequence ID" value="POY70683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1N0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="183" mass="19841" checksum="1418DDBE00E02E05" modified="2018-07-18" version="1">MAGACRMEVPQRDGREEAGILAFTIVTCLESRIRWARGSCSTRPRTSCAIRCPTAISAPVGQELIRLVARRLTETASRSSRLARARSHRSRVSEPALAARLTAAIAGLPSAPYRILIPPAAYPLTHLSCTHLQYCHIPARFVATPSPPRLELDQISSGLPDSTSRDRMTANARSNDTPVARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1N2</accession>
    <name>A0A2S5B1N2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000107">
        <property type="protein sequence ID" value="POY70665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B1N2"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="665"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1431" mass="150189" checksum="3E40C9CC4C9B566B" modified="2018-07-18" version="1">MFQLTTATQHDVMTGPTSSSAQTRFAGRIPPSEQPHPHESRHPYSKGVPASPSHKDHPRNISPPRPPLHSDGDEYGGQDGAVGGGGLMMPRPPSSKAKTVLFTAPTYYAHSATGLTSEEEEGGEEGAEPEEGYYEGSGDEMDEEAEGHERGERDELRQYGDDDDDVDVHEGRPDFRDDDFVGDHDDEAGGNRHRYEHDADIEDADQQENHDDSTTLVLGQPVASSLTAAAAGTASVRSGLPAALIPGAGGGGLAAQAGGRMVLESELASSREDRTPLVDVNERQLASSSPASGPAGLGIGLGGGGVGAAAGGSLDRIGATHSTSLGKDVSAAAAPPPATTTTTPVSTLTREFNENELLDPAAPTKKLSATPAIAREINRGPVSSGNALASSAPPGPSPFGADLAATTNNGGGDRPPKRTIRGVEVVDPRDPRDAGSGSEKKRKSGGGILGLFRKKDKKKKGSVVATEDDASGKSGRRPSEESLRSSTSSGGAAFHRSSSGSPSGFRSSSDRPPNGNRSSGAGGSASTAESMFSTDAALRQQELEAKQALYQQYGVSRGPGDVSNTMTPRGMPGGLVMSQGGQQQQQRDASPGPQSRLAASGSSTSNRNSLSLLSHPASMLGASTGLTAGSALNSPNSLAPPQRTRPGSLIGSPVVSGVEVPLLSVMRVFAGENVDSDATFKTVLLNQSTSSAELVKQAMQRFRLTAPHLRPDEFYLTVKELGGDERRLDAEERPLEIFEDLSDRIGDEGLALPPNVKRSSIGSINSISSNLTLNPAITRSGVGDWSDDSAVKFYLHRRPPVNLGNSSLDLDRSHGSDAASRSTSEHGDVSLNSSGGSGPSYRFAVRLILPDEELPEHLAFDPLSEAVIPKTLLAERRLRLGDGTPRNGPRQRIIFFPRNANVSEVVETALDRFGVADGVVDGGDEVEERVTRRRSSNRIKYILAVEREGQESFLSSSSKLLDAYSVPPAFKAYDRSSREFRRRSAEAGLILGLSSDVLPTDPVFVIRRSPHRSAGPRGVLPQSVDELDELRQRRRISSDGVRSSPRTSDLGVRPSPRELIAAQRAASQANQRALLSGPRQDDLTSHSQTTLRADEPSADDIRFSILSEGSSADGGVRPEALQGLGLRPTDNLSRGVSAADSFQTAQTSLDRTPLATPGIDDDEAAIVRLRAAEVGVPSSESGVVPAVGAPRSASASPRPLSPTGLEESLQERLDRVLARVREDKARRAASPTPTAGQRPQSYIDTSSGAGASGRFSPVNVATRSASALGGRRSPFGDKLSDSPSIVGQLLSSPPRRSVSGEQPGPISKGSVTSMSSAGSTATGTDHLSTPIASSNAHSTGYTPASSATGTHRAPLVYPDEYGFNFLAAVAAAGAHTFAAPRRPEPRAFYERAHDVLADAHPEVRRTYGDSAHALSDIEARLDQLLVRLVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1U2</accession>
    <name>A0A2S5B1U2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_6159</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1U2"/>
    <dbReference type="STRING" id="741276.A0A2S5B1U2"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17 20" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="34"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="590"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY70749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="733" mass="77852" checksum="828EB8CD545F1D40" modified="2018-07-18" version="1">MFALRSRTSALESHAYALRRALATHAKLPQTYIEKVVQRHSVGLPEGKVVRAGDYVMIKPQHVMTHDNTGPVISKFSSIGATKISNPRQTVFTLDHDVQNRSPANLAKYAKIEAFANKHEVDFYPAGRGIGHQIMIEEGYAFPGVMTVASDSHSNMYGGVGCVGTAIVRTDAAALWATQRTWWQVPPIVRVNLDGNLPKGVTGKDIIIALCGNFNKDEVLNHAIEFHGTGIPQLSVDERLAIANMTTEWGALVGVFPTDDVLQKWYESQLKKLELRKFEFGGSSSGSLSSSTSQHPRLSAGRLEQVFQNPILPDEGAQYAKTLTLDLTSLSPSVAGPNSVKVATPLPVLEKDEVKINKAYLVSCTNSRASDIKAAADVIRGKKVAPGVEFYIAAASSVVQKEAEASGDWAALVSAGAKVLPAGCGPCIGLGVGLLEDGEVGISATNRNYKGRMGSPNALAYLASPEVVAASAVAGKIVGPKVPGASPAGEAPKISIEVHKSAASGEAASTSAVSEPLLPNFPPLFSGPLLFAPQDNLNTDGIYPGKYTYQDDITREKQADVVMENYDPDFASIMKSLESPARSTNPAGPQRNGEGVLLASGYNFGTGSSREQAATALLSSGIPLVLCGSFGDIFKRNSINNALICVECPELIEDLTNDFAAEGKRNAGGKYGKLTVQTPYWIEVGSVDGKVTLRKEKGGDVVKEYRVGAVGGSVQEMWLAGGLEGWVKERISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1W2</accession>
    <name>A0A2S5B1W2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1W2"/>
    <dbReference type="STRING" id="741276.A0A2S5B1W2"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="51"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="447" mass="49246" checksum="2C0B1DD74F114923" modified="2018-07-18" version="1">MSDATYADQPPTDIINKGVPNAPFYQPLTEPSPGTALSADDWPQNKELPLLFQPLTIGKDAQIKLKNRIIVSPMCQYSCQADGPEAGVLTPWHLVHLGQFAVRGAALVMVEATSVMPNGRLSPQDSGLWNDRQAAALKPIFDFISMQGAVPAIQLGHGGRKTSTLAPWLDTSTVKAPLKSHVATNGDASGWTDNVWGPSAISYDDETFPMPKEMTLEQIEELKDAFRASTERAVKAGAKVIELHCAHGYLQSNFLSPVSNQRTDKYGGSLENRMRLSLEVLEVMKKTIPKDVSLWCRLSASEWWPEGEKNDKGEWISWGIEQSKVFCKEAVKVGVDLIDVSSGGNTPRQKIKVEPGYQVPFADAIRKSFTEEEKIPVASVGLITDGKQAEQILQDGSADVVSMAREFLRDPSLVFNWAQELGIVCSVPVEYQRAYTRMMTKPEDKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B295</accession>
    <name>A0A2S5B295_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B295"/>
    <dbReference type="OrthoDB" id="2538059at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="446" mass="49469" checksum="71BDF7E27CBF8CF3" modified="2018-07-18" version="1">MFYHRPSITPSWCPRIYPVREPSFAPPVSSDRTSPPTSPRPRARSLATLGEAPATTENNAGSATTPAPVREAPPPVYYPGPAQRRLSAAARGIDDSVPRGHIASINTARTSTCVVRWLKHPAAPEAMRPRDEVRKRGFRQDWRSWIRLPLIWRALKQEPEVLWNGWPVEFGGQTRVPWEAEMLREAEEGATANDGQILPPSFSPHPLGAMSITEGVALSRLSSTASVVKHPLEAQYRRRIAELNTLIAESLSLTRIWLALIELMDIIWLVCLIIAIGVEKGQQKGFILGVEVGLVLVILLNGLAINGVRMRRWTLAQGLRARTRDWSPLPITSSTNSGLMRNYLDGDASDRDRTDSMQPKEGPVLRWRLRETEGGYWLGYRPIIRCELVVPASYAYSFATIDHLPVLAHADSQSPRESTSTTEALPSVEEGVPARGPEPPSYDQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2H1</accession>
    <name>A0A2S5B2H1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000091">
        <property type="protein sequence ID" value="POY70979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2H1"/>
    <dbReference type="STRING" id="741276.A0A2S5B2H1"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="902"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="5">
        <location>
            <begin position="98"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="4">
        <location>
            <begin position="920"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1204" mass="133302" checksum="1A243A24D8390AEA" modified="2018-07-18" version="1">MSSKSPTSPARPEAGSTDRQDSAGSSSQSPVRDGEFSHDVPSKDETKKQRKSARNKLPSMIKGPLDAFFPKFTPSPLYASEPAFVREANDRSKWRARKIYIRTCIVFLGNMILMLEQKSLLVLGNAGFFGLIVSAMLPPMFPVQLFLIVSFMLVLGMCLGWAWACAGMAAALRARSQVLLARQVQTTRTSIASATNPDSAYRRQIFEGAFLDARSTVVFGVFLGTGAFVFGLLRAKRPKLLLLSIFGTIVLDVMTAYGPLFPIKQYTLATTFLIPTGCYVAIALAATILIFPQTLNHAWTIDLVDTFLSPTRQRSDLYAKLLATPPVTIDTTDLEGHPWTKLGAMWVSTQEAMSTGLEGLLGGIGLTELEVSRGHLSAKDLKSLVDPLQELHIRSLGLAGMWSTVWSRVRRHQEDSHGELDHEDSHDAHDEKPKNGLTGRRRNGGRHTHMGNKLHEAEVRNKHDFPTMLALFNDVTQDVRHASDAALAGSMDWLIAQNNARYPFLGGKKTRENEENRFAELAQATKRLESEIALFRQEHRRQLVEPFRDFFDPETGQLFSQEERRKRGGHTAHERLFAPGSLFTILAAADSLIVYLESVQSFTGRLSALAQQRRSSRLWFPTGIRKIGHLLAGHHHGAGPDVVSGGQDPDALESAEVDDESSESATLSSQRDREASSAQTRKESKRDQKGKPQNPFDQLMKTETRDPDARPPRNALQRIGVVGYGFLHWWTTPDVIFALKYTAASVVLWLPQVFETTAFLMYSEKLLWAQITAQTFMAPYAGDQIFTTLQRIIGTVVGLVYGMRGLGTLWSWLVADGSISTAACQWYLGAAKGSGTPVGVGSALFVMMLPLLAIRLHAPPASAMIAIMVTVTTVLVVGYSWIDEKLARVGNPGVGYNVAWRRGLLVIIGAAVGLVFLLLPPSNSTRKLVRRTHAKCLEQLGRVYAAITSLWVEEQRREHRLANKQDESFDSQQLVDGESAPFGKASQKAARARLFAIRNKLNSTKISNLQAAFELSMKGDWPKQEYLRLLRLQLALLQALGQLGQALVRLEPKWRKRIVQETAFLNQPLIADVATTFSIISLSLRQGVPLPAAMPGPLLDRLIYHDSRLRAFSQSLTQRERGDEDDDDDDEQATKVEGARVGDFKLTFDVLADERFGVYASALEALANILLDVDELELASKALLGEISFPGYSMLAQRERFGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2R1</accession>
    <name>A0A2S5B2R1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_5829</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2R1"/>
    <dbReference type="STRING" id="741276.A0A2S5B2R1"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="717"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="218"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY71072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1227" mass="137628" checksum="405D71D8D5F59228" modified="2018-07-18" version="1">MSLDHNKNGEPAPLPSFSLSFTQNLLRQYYSTVCTLRDLLPAQGGTVTRQNDSESFQRLVGETVVASRSLTGAPKLSHEANGRASGAAMSEIIEQVQQRLFAAHAKEYYREKKAGNVAFATPKNVLAFGYRLSVHLQETDRTRQLARTRSQLEHGFVEVFPNTVLASLIASRDWDQLAARVNPDWLIDLLSSPDTALFLPLPNACLMQISGTPVADLKTLDESREKHDRGSRRTRHRPRKRKRRRKATEEVADDSVEEGEQVARPVSELQAEIPDVRIDTPEGAREPALPKAAPLAATRSLPFLCPDGAVFSTSSTNPHLGPDALPISPSKNTLRPTRSATSVFGASEASERPVKRRRLETLNSNNAIVLARHQMYHHRLAKGTGGKLPYGLSTKHILGRLPNLYPSTTALPVGDRRANAAKGNSEAAARHLAKYVFPRQFGLHNVFTRPKPRASLDVLPDYADRELEIKRLGSVKTPARLKPVLPLLQKLAVLHSRCNYRKLLDRRCPSRLKRRQVSEEDQSVVLDMSAELRTQMSHGEVSLDVSHASLVVPHGQTQAVAQKTKKPKLSDYACTVYEVERYVLDCVRDVVPNAFWGSEANRKVVKANIAKMVRYRRFESLSVHALLQGFSMLECEWLRPASASAARQRTTTADVKKRHELLSEFMVWLFDSFVVDLIRTAFYVTDSVTHQNRPLYFRQDDWNKLCAPLLKQLGESVFEKVPHRDRELGVSFVRLLPKETGVRPIVNLARRPIKVAAGGRREVGQPINKILQGVFDVLTFETKRKPHLVGSLVTDSQQIYSKLRLFKKDLQGRYAGDKLPKLHFVKVDVRAAYDTIQQDKLLQIVEGVLQETVYWIQRYSQVSPLAGTSLKAFKRAACTDGELGMFEDLAIKLAHDLHNLILSDALLREHITTNLVKGSILSSLLCSLFYGDMEKTHLAFTQAEEALLLRYVDDFLLVTTDLQLASRFLRVMDAGLPDYGCAISPEKRLTNFDISLAEAEVVPPLHEGHDFPWCGLLIDTKTLEIRFNTGSSEKARVDVTDLLTIQRHRKPGRAFLNAMFRAVKIRSRIMYVDTAHNSLATAYGNLYRSLLVVALKFQAYVQEWGIDARRKSAFLYGTLEQIVAFQWSAIVNQSRSLKAHALGAELALKRSWVTWSVATLSDLLGLHAFHRVLSRRPGLYGAIATKLQRELRAPKYGGARVHLQKVIAADSTAFADRANGDRKAQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2U0</accession>
    <name>A0A2S5B2U0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2U0"/>
    <dbReference type="STRING" id="741276.A0A2S5B2U0"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
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    </dbReference>
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        </location>
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            <begin position="1"/>
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        </location>
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            <begin position="91"/>
            <end position="1107"/>
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            <begin position="1"/>
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            <begin position="35"/>
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        </location>
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            <begin position="45"/>
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            <begin position="1092"/>
            <end position="1101"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71103.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1107" mass="118157" checksum="3F875FEAC6DBB6A0" modified="2018-07-18" version="1">MDDELDFGEDELAPLTATAAPPPPPLLAATASAPAPAPAPPAMQPAPVTTTTAAATPAHDDKLDENGQPLPPGWVSRVSKSTQRIYYRNTLLNTSEWDIPTGPAPGPNGTLAASLPEPPVAPAARAQLPPAAPPAAASTATTTTTIDPAPTSTSAPATTSASANRSDRARVIESDTSSSRAIPREREREREEPASARQNSSREKTTEHSSTSARPHSRDGPRNDAREPERERERERERERERERERERERERERERERERERERFATDRYAARDESTRYASASNTSASSAAPASTTAQAAPPYSPNGPTFAPPSTSRRSRGGRSRASGGAAMTDANSIPVAPRKATSTSAQSPTEGGKEKEVAAVAAAAAASGTTERALNDRWGSRRPEAQSKSTSARDAPPASPPRSKDVPPSPAVDDRWAPRGSSSRTDRRPLSPVRDNGYSRDRVRGSSSSARDEPAAAAAAKSPVAASSASTDRRPEDRPSTSTTTAARDRETRAQSTTSATSSASGLTPAERLEQQRLARLAMVEGRAPGPGPALIGAAGSPSASTAAAQKDVPPHLLVDDKFARDDGSRGGEGGGRRRGSRGAPGSKTNLGPPPAMVGDRFAPPPGYGRGPEPARDRGGNDRFAASVSAPRPPPVSAKGANAMPVGAAGGGWGDRARIAKEKADREAEEDRRRDKERAAREEEDRRRRAEEDAERRRRAEEEEVERKRRAEEEAERHRRAEEAEKERERSREAERRKRQLEEDEARKEQDRKKAIEDERVARERAAADAYASRAGRGRPRSRSPPPPISTNASGRRPLSPPRYGDRRPLSPPGNNRYAPRGRSPSPPPRMRRLSPSPPPFARRGGRSPSPGPYRRPYDSPPRRAYSPGPPPGGSMYPPRVRNPSPPPLGGPSGGYRRSRSPDLPPPIHMRIRGARSPSPPRRRGPFENGYGVPDKCPAHFRGKYRDPDEDVNVSGPPTLLIRSAGPALPAPDRVAPEPAAPEPAAPAPTSLPPPPAKLGDRVAPAPNEASTSGGGGARRGRRRGARNGNANEEKGGQSPRPTGSQDTSGSNKKADTPSAGGASLLSRLSLPQKPAMPNGGPAKRSRGADDNARHEDKRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B345</accession>
    <name>A0A2S5B345_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
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            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="POY71197.1"/>
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    <dbReference type="STRING" id="741276.A0A2S5B345"/>
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    <dbReference type="Proteomes" id="UP000237144">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689:SF1">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="173" mass="20195" checksum="300A19402CB6E048" modified="2018-07-18" version="1">MTLAPAREEKKRAKAGLAPVEWGKHGILTEADIYTKSDEFHAWLVGERMMNPETTTKAKEKELFKQFMEDFNTGTLPHEKYYDLKKYETRMTAIKMGETVETSDSYDFNRDLESAKAAHRRSSSAIDDQLLDRKRLEDLRRVQSERVQREKMTRLGFEVSENLGVRLEDKMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2S5B351_9BASI</name>
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        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5525</name>
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    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="198"/>
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            <begin position="325"/>
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        </location>
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        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="542" mass="58558" checksum="0CC7F4C823003A56" modified="2018-07-18" version="1">MASSDSDKSDTDETVQPFKGITFYIHGQWAGWTRNKVTRALESGGGQVSDKLENVKISHMIVSEQLWSRRSTANADPTIKRTMKANEENRTEEDEDWNRVWLLPIEWLEQSLQEGSCLPEVEHDLERMEDEKRAERSRELAKERRKYGGTSRYGRGQRRKIEMQRAMDAELRRQAQVEKQGLAPDPDAFAGVAVLPGAFDATPLGPASSGTGHLASDPLGASSNGTRAQENTGSSAAPANAAPASSFASQSSQQIDLSSPDPLTLERRVHHTSKMSKGQASSTRTEPAAGRSTGKPRPAKEKEKSDWSSDDMTSSSDEEPPSAKAGKKRNEKKARQQAKAKPATGSSDKSKATMGKLGKSAREQALEAIAKSPSKPKADSAALPAAASQPKKTQFNDFRKQPLTLFSGGSMHMPSKPNKPTAGASNETRVKQADKGKPAAKIHTSDGGSSSDEVPLKKPADPRRTRSKEAKRAALGEKSRNAKTDEKAKPSFKVDANGKKRARFVGDTSDEDEAPRSTKKGKTGAQKAKKAAAIVISDSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3N4</accession>
    <name>A0A2S5B3N4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3N4"/>
    <dbReference type="STRING" id="741276.A0A2S5B3N4"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="7">
        <location>
            <begin position="372"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="993" mass="106277" checksum="3D48D97F7D96F1D6" modified="2018-07-18" version="1">MPGELKPDTLPVIATKTLPSALHLPDEALSPTTPSLVLLTSPPDATADPKVILYRLAPASTDLVWEWSPPPPPVPAPTGKLGGLGLKGKAKAQTNGGKVERVEWSPDGQAIAVVSSYPATSPTLTVLSVHAGQPIVPPLPLWNRSDKDGRCTHSSWQSVSLQPEARLEQWALRIIEQSPALPKIEKGNIAAAGVDGSGGGPSIGGARIGAAGPGGAGGGGGGVFGAKQAMLERERAKEAQRPLSMRDAASRFPTLLPSPDGLDEADDDSDPKVVASLKGRTGRTSGTPSREQGMEGTLSCVSNDKGVCELFLSGCVHLGAVDVGGRVLAVTGIPPQRADGAAWTACSVRLVAHYMDSSDSLAIRTISVPVPATLRTVVRHSTALRAVLEHAFEALQEARNLWDEARRIGKGWLQRLGDVSRPHGVKHSPATQLHLLLVTGRPTRSLHDFLASKLNERGLVKWEQAMAAALERLREVGWLSIVPALERSVLLLREMDAWARWPERFGDYGFDRVSTLKATSAAEAGIRSAARLQHEAEEEERCFKHFSAWLHYELEKVAAQEGSETRPAANFQPTPVSHYIQHCLPPTAVSLSPYLSFGLASAPLASNADLAAVNTWLSAMHDSPLPQDHWIDSFAGGNGDLSDTLKRVKQELRGQIDAERLDQALEAEARDAADAEEIAWAIRLPYAGLEGLDTSSPIDVERPTAHFARDEQLRDRDERPQPAFGGPSELAPRSLPALLYTIAQLSGAAFESAISRVTGQQSTLGDLSTGDVVRRPRTVRARIVTAADASLWLCSVAVAQNSGESAHPEVEPADRLLTRWARGAVHFSRRPLDPDAATAPMYATYSLPSNPAEAAVSVLAVAFKSDTEIVFAVTEEGPSKRGAAQCSEISLDDLAWAEQPEQVSPLLAAPTSHWNEYVSDHYLTIADPPATSQCHLHAGRRLPSLASFLPNRTPVGDRCRHIIGRRTSYRSIAGTHKGGEDVASIYASGRNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3W3</accession>
    <name>A0A2S5B3W3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="20">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">BMF94_5782</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="25">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="20"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B3W3"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000025">
        <property type="entry name" value="Bifunctional pyrimidine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000011">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000036">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000009">
        <property type="entry name" value="Carbamoyl-phosphate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 27" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 31" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 27" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="29">
        <location>
            <begin position="618"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="29">
        <location>
            <begin position="1154"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="30">
        <location>
            <begin position="1411"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1932"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="1943"/>
            <end position="1955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="POY71469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2308" mass="250963" checksum="A9514B071B044756" modified="2018-07-18" version="1">MTATPPPLDLAVPTAANAVAPSRPASPSTRVAGRPVQPIVSVPSQEIATLYPSPDAGVKGAEPVKQTERMLLELADGSAYEGYSFGADKSITGECVFQTGMVGYPESLTDPSYAGQILVLTYPLVGSYGVPKRPAKGTVSPANLPREFESYKIHVAGLIVSNYSGAGEDFSNHAAHSELAEWLREEGIPAVYGVDTRDLTKKLRERGSTVGRLSQRKRDVPYQAGASNWRDLYEQVEYHDPNADNLVAAVTTPKPVLYSADQGVTALRHPSGRNLRVICVDVGMKYNQIRCFTKRGVELKVVPYDYDYLASSEEPFDGLFLSNGPGDPATLKSTTELLAKALDLAKFPIFGICLGHQLMARASGANTLKLKYGNRGANIPCTSLVSGRCYITSQNHGYAVDTATLQNGWKELFVNANDNSNEGIYSTERPFFSVQFHPESAPGPRDTEFLFDTFISAIQQSLEKQAKGEQLTGPVAFPGGDAAENAALTPRVDVRKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYFLPVTADSVRKVIEHERPDGIYVTFGGQTALQVGIQLKDEFEGMGVKVLGTPIQTIITTEDRELFAQAMEEIGEHCAKSAAAETIQQCIDAANDIGYPVICRAAFALGGLGSGFANNEKELVELCTKAFATSSQVLVERSMKGWKEIEYEVVRDCRDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDSDYNMLRTTAVNVIRHLGVVGECNIQYALNPYSQEYCIIEVNARLSRSSALASKATGYPLAYTAAKLGLNIPLNEIKNSVTKDTSACFEPSLDYLVVKIPRWDLKKFTRVSTALSSSMKSVGEVMAIGKTFEETIQKAIRAIDPSFAGFGKNAFPMEEIDEELQKPTDRRLFAVANALHAGRTVDEIHKLSNIDKWFLHKLEHIVRVEKTVEQFTASQIPTDLLRCAKRTGFSDSQIAKALGSNELAVRRLRIDHGITPRVKQIDTVAAEFPAFTNYLYMTYNGASHDVEFNDKGVMVLGSGVYRIGSSVEFDWCAVRAIRTIRERGFKTVMVNYNPETVSTDYDEADRLYFEVISLETILDIYEAETSQGVVVSMGGQTSNNIALPLHRQGVKILGTSPENIDMAENRYKFSRMLDRLGVDQPLWKELSTMEAAHEFCEKVGYPVLVRPSYVLSGAAMNVVYSRDDLDAFLGQAAAVSRDYPVVVTKYIEEAKEIEMDAVARDGKLVMHYVSEHVENAGVHSGDATLILPPQDLDPETVRRIEDATAKIGAALNVSGPFNIQFLAKNNEIKVIECNVRAARSFPFVSKVTDIDAIEMATDIMLGLPITPYPEMNLPKDYVGIKVPQFSFGRLAGADPILGVEMASTGEVACFGKDKYEAYIKALLSTGMKLPKKNILFSIGPYKEKLEMLPPIRQLQALGYNIFATVGTADFLQEHGVPVKYLEELDDDDEKQAQKSEYSLREHLANNKIDLYVNLPSKNRYRRPASYMSKGYRSRRMAVDFAVPLVTNVKCAKLFIQALARNPSLAISSVDYKTSSRTIVLPGLVNTRCFVPGVATAGSKDFEQVTKAALAGGFSTVQVLPIGEKVSITDKSTLDIARDNAAHAACDYSLCVAATADNAAALTGSIVSAARTLFLPAQNLSATPDKVSTVAAHFSAWPLNKPIVTDARTTDLASVLLLASLHGRPVHVSNVQTENDIQLISLSKNKDLKVTCDVSVYSLFLTREEFPGATCLPTARDQAALWQHLETIDVFSTGALPQRLATELGKPYAPEAGHEEALQLLLTAVHEGRLTIDDLVARLSENPRSIFDLPAAPADTYVEVEVDRTILPVKRSYWSPIAGKKLSGSVHRVVVAGETVFLDGSFVSKALPSGRDLSSLAGASKTDRRQARFSVSANRPSLASLGFPSRDAVASPAQPAANQSIIKSPKFSSSRSPRLDAASEPALQPSLMSLTAPVSSALAPASPMAGLVKLLATAAKAYHRRHVLSVRAFTRDDLHILFGVASEMRMLTERGVPIDLLRGRVLSTLFYEPSTRTSASFEAAMGRLGGTTVAVTAGTSSVVKGETLADTVRTLGCYADVIALRHPAAGSAQEAARYSPVPIINAGDGIGEHPTQAFLDIYTIREELGTVNGLTITMVGDLKNGRTVHSLVKLLSLYSVSLIFVAPPSLEMPESVKQEAERAGVPVLETTSLASVIGQTDVLYVTRVQQERFASQAEYEAVKDAYIVNNEVLSGAKEHTIVLHPLPRNQELDPDVDHDSRRAVYLRQMRYGLYVRMGLLALIFGQGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Q5</accession>
    <name>A0A2S5B4Q5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Q5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Q5"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="134" mass="14997" checksum="A320C04C7AB08A26" modified="2018-07-18" version="1">MFSAFRSSAPCLKATSRSALNAKRRQTGLYDGRTIQSGNSVGETFNNKTRRTWLPNVHPKRLWSEALGTNLRLKVTSGALRTIDKVGGLDAYLFRMRPERLGEKGMALRQMVQDAHARAKAQRRAVEAQQSPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4W1</accession>
    <name>A0A2S5B4W1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4W1"/>
    <dbReference type="STRING" id="741276.A0A2S5B4W1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="834"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="987" mass="108415" checksum="B94C7DB9BD769505" modified="2018-07-18" version="1">MQQSQPHPLLASLSSTARYQSPVRTSEGGDHYQQPGPNLSSATTVHGSPLARSPEEYPHAHRQSSPDRSLAGGDNGLATATSAKRRRTVRDGDRDSEEPHGGNKKMKVLSCTECKRRKVKCDRKIPCLACCKRGEPEACRWPDETDKPQVDVQPFALTGDLLVLARRIQSLEEWAQSLPPDMRQAAPLPQGFEPSLYGTTSKHKAQELGTHVRSGKPRSRSHTANKGDLGDDGSFDAPSRELSETEDAALQLESMAFATRHPDSHYRPLDTLPFIDNAASPSSATLLKRSIADAQLLQARELTAWGTSILAQPLVYEGPWSGTALGLDLCFSLEALRARFSAALATMWPHMPDRSLSHKLVAKYFDEVAWVHAVFHRPTFEAEHARAWEMIEAGRQDEIDPLWLCCYFLVLSLAIDGLRSNEHTIELSPEESARCNSTVWYAFAHRLVQLGNGIGRAQVRFIVATILIGQWLQTSKASGRVTAFLTMLAGAMRTAQILGLHQLGADPKHMPLPDPAWPPTVCSMRRETALRLFHMLLFYDCTSSQRMSASTRFRSFLLDPGHCTTPEPSNLNWSDLSITEWRIEPKPRSTLSDMSFEYAKSRSSEAYRLAFDKLLSGSADLSYSTILELDRTYRSVLRESTQALQDSEPGRDGKVTVNQWKRLICEDGLHSRLIRLHRPFMTQYDTSRKACIESATRLLYIHSRIAPMSRMVWFVYVHSLSAAICLFVDLFHAIDHDRSSEEIEERRSVLGAALDIFSHAEQVRSPSLRAVVETGLGIIRGLLEASDTRRTARAAQVLLGGKAQQHRPAESFAAVLQRLSRQLAVDAQTSPAKPAAVALAGSSAPPPQKPDPGYSAELPQPPPQAQVPFEYNGAPFGAPNDMSYLGGTSAEYMPTEFFRDVGLTPGVGFGLDYLNTGLPSTAPYDLNGYTGSQNGAALYDPSQAGGGGGGSVNGPYDWPAFAAGEASEEQGKLAASALMDQLSTGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B510</accession>
    <name>A0A2S5B510_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B510"/>
    <dbReference type="STRING" id="741276.A0A2S5B510"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="137" mass="14668" checksum="B3C759EAD05ADB6C" modified="2018-07-18" version="1">MAPTSTKGPATAATGGKAPAKKSIKSVSSKSGDDKEGKKKKKKARKETFSSYIYKVLKQVHPETGISNKAMSVMNTFVYDQFDKIAAEAGKLAAYNKRATISSREIQTAVRLLLPGELAKHAISEGTKAVTKYSSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5H7</accession>
    <name>A0A2S5B5H7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5015</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY72006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5H7"/>
    <dbReference type="STRING" id="741276.A0A2S5B5H7"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="767"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="942"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="413"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="691"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="611"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="985" mass="106824" checksum="552A1251EAD0C6D9" modified="2018-07-18" version="1">MADPLSAEAHWGVDELGVGLSDDADTRQLAPTVPKTVSPLTARRSRTDSNATQRERVASEVTLSSFTPRGHDSPLARRLALSAEPADAERPPLSRQSTVGAGSARRTRGYDRTTRRNLIAGAAADGDLVRLQALLVVPEDVDNGDRPASTFGLANEPHPHSGLAPIHFAAQNGHEDVVKWLVEEAGALPDFEDAEGETPLHKAALRGHLDVCRFLLSRQPLHNAASRGWLDVAQLLLTFRADPDVANRHGFTPLMNAASKGHLPLVHFLLRQARADPLRRNVWGETAFDLAASVFEFEICRALAAAEQRAITSESALTLPVEGRHRERAYNPLALHTTVPVVLYENQRLVTPSLRRPASLVPGHGDALVWSLKALTRNDKRAAFSFPGMLGNDTSDADLPCFKSEVGLPIVGQENEMVLPPRREVRSGGRVQAESERPRPTPRRSSSRSSMVSGGASSATMPDQNDDDGSTSLAIGGRVEPRPEPAWMWISDWTVDRTSPTSSPRDGWSYAPSFDTPATEWSATPPMDASGASLLSTSASGARKWVRRRLWTRVMRRRVDLPDWGFDGAPLRLSEPDAELQDLARVGYRARARYFAGEALPGLDAGETGALENANRRKAIAQLERAAEELRRGLDQEEDEAAMRGAQADLEEYLRLLALLQSRGDGSDTLPAEDDAFIYSGVDAEDDDARSVWTSMRSPSVASSSAGGHRLGSRSASFQSTHSSRPVLTAQTAPEFRVPTNELVTSSRSLASPHLFGQSIRPPWEPDHATSSCRRCSKHFNLLNRRHHCRRCGLVVCAACSPHSDQLDPRQVAIEPGTPADDSPWLLDSPSGYRYRTCNDCHSALALVAPEQAGPSSLLSPQAFFPASSSLPGSAAPSEAAASDVSELVECPVCGETLAQVGDKSAQESHIRECLEAGKGSIASGRYLLFRLPPGPLVGEDCNICWTEFEIGDKMARLVCLCTFHEKCLSGWLARGNSCPVHARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B626</accession>
    <name>A0A2S5B626_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1690</name>
        <name evidence="12" type="ORF">BMF94_4798</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B626"/>
    <dbReference type="STRING" id="741276.A0A2S5B626"/>
    <dbReference type="OrthoDB" id="2532770at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="11">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="103" mass="11395" checksum="4BCE0A1C8DA37164" modified="2018-07-18" version="1">MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENIIRDSVTYTEHAKRKTVTSLDVVYALKRAGKTLYGFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B673</accession>
    <name>A0A2S5B673_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B673"/>
    <dbReference type="STRING" id="741276.A0A2S5B673"/>
    <dbReference type="OrthoDB" id="2528141at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="78380" checksum="591526FBB9D8C4F9" modified="2018-07-18" version="1">MSSLRQELKQFEAAFRKEHGKDPSPQDIRARPDIGIIILLPLSNTRNGSADSPRKYKQYQREKSAAKGGKPPSSASSQSTSDRPVASTSTAPANPFKTPTKPKSRSRATRPAEAGPEGPSSDVLMGPASPSQRLSAGSSRSRPASQTTASTESKAPTSQERYVVANSPSKLRALAALHSTSGSPNKRSSATGLASTASDSSRPAAPPLFFESLQAKSAGQASSQKKAANPFASPQKGAFGAFEREERERLRAKRAELKKQRRVSSSSSVLGKGATSAGAGWGTATVVPADERTPFARSASRSSASGMDLDEVDDFFGGGGASRQRSPREEGQGGALGDGEQQYEEDESLGPSPVKPATGSASLGSDLAPPFRPFQPLIPDRPPPSSTSSSTRQPSQPPSARPRPFLAPLPTSQTGVVSSVALKSESTVPQKRADPSDRADAFHADQAEKPDAKRKKVAGGTKVPESATSTANGKGKGTAKRAAKAVAVGAVQRGPIGEIVVEVGGSDEGEDEESESSAASGSDAEAEGGAQRVKKKRVRKPTERIVIHDKAAMARQKALERQERYREREGGGDDDGDAADEEGELEAIDVSTTRDEDRQALEDDFPDTSLFGPARQVDLLAKLGARPRSRSRSRSPSTREADEQAALAASLPADLAEILSLRMSPSKAHVSSAKARQVARILGEPSGRRATGRTKPGGLLDFASDDEDGVGRAEDDAEGDDDWDEEVDGWEGAGEAMDGYYSGGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B697</accession>
    <name>A0A2S5B697_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B697"/>
    <dbReference type="STRING" id="741276.A0A2S5B697"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="436"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="713"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="801"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="856"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="909"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1019"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1097" mass="115913" checksum="F0F2EE61A81EF118" modified="2018-07-18" version="1">MATPTPTGSYAGSGSSNNPPPPPLSMAGGPPQQGPSVLQILAMGQDRNHAADAMAHHPRIESLIKLGKEAEATWLQIGQTAEAVSDYDRAVAAYESALRHNAYSVVALSQIAAIYRSREEFKKAAEYFGRVVSIAPESGDVWGALGHCFLMIDDLKKAYSSYQQALYYMPNPHEPKLWYGIGILYDRYGSLEHAEEAFSSVIRMEPNFEKANEIFFRLGIIYKQQRKSAQSLECFRYILNNPPRPLTEIDIWFQIGHVYEQQKDFIAAKESYERVLQENPAHAKVLQQLGGLYHRSQAPFYDPEMSVQILTKSLESDPNDPFSWYLLGRAYMTTSNFGKAYEAYQQAVYRDGKNPAFWCSIGVLYYNINQFHDALDAYSRAIRIHPYLAEVWYNLGALYEACNDQMTDAIDAYQRTLQLDPSNTTVTQRLSEIREHQTSGAALSPPPAPKDISPSSMSWSYATNSGGAPTQLAQAGLGPDLSPSMGPQPPAPNGAPARVPTSGSGASPHAGGSRLEAISVNGGRPRSTDPYRRSAIQHSPSYNGGGPADRSPRYATPATPGHRLPPYKDGRAPPNGRLGSPPSPRSRPPDGTAGQPGSYPFPAHLTNGSHSRDPAGSSDGMDWERSRAGGVRNGPPSGLPPRGGALHPPTHPHPYSSAPGHGQQHQTQQHAQAYSGRSPNMQPPAVPAASPYERAGPPGGARPPFFDNPSPGPYGAYPPASSAAAAAAEEYARRRSSGSTNGSQRSGHPETKPTIPSLDAAMNGPSASTPAPTPPAKGRGSRKKAEGGADGPKKAPRRGKGSAAAAAAAASADSADGSAASTNGTTTPKKRRAKAAPKTAKEPTSTELQEKETEEAAQAAATLTGGSPTQPRAQNVALPREEPAGQQREVDEEYDEGVDALMSLGGGARSEASPPAARSAPSEPALDASTSRKRSLPVETAPEAESTEQDGPTEPNAKRARPDPAAPQPGEAATPPPPAAQAGETEGVLGPARTETTNMSGDATEEIQARRDAEERQAEAAPPAADSEPAQSSTQDENAQASAARAASGEDKENIGESASSELAKPSVDAAREEGAVVTAAEDTATIQADAAPSPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B732</accession>
    <name>A0A2S5B732_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Proline iminopeptidase</fullName>
            <shortName evidence="8">PIP</shortName>
            <ecNumber evidence="8 10">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="8 10"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B732"/>
    <dbReference type="STRING" id="741276.A0A2S5B732"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722:SF1">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="11">
        <location>
            <begin position="36"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="318" mass="36329" checksum="0F9D0A7AD3F309C1" modified="2018-07-18" version="1">MPSLYPPIKPYKTEHLAVSDLHKLSVRQYGKQDGQPVLFVHGGPGGGCDGKDAQRFDPEVYRIVLVDQRGSGESLPPAELKDNTTWDLVEDMEKVRKHLEIEKWHVFGGSWGSTLSLGYAQTHPDRVKSLTLRGIFTLRRSELEFFYQGPGTDNYFPDFWEEYISVIPEAERNDVIKAYYTRLTSKDDKVRAEAARAWSRWEMATSRTEIDKDYLDRAEDAEFADRFARIEAHFFVNAGWMRDGQLLEKESIDKIRHIPAVIIQGRWDSVCPAKTAWDLHRAWPEAKFVMVPDAGHSANEPGIEKALLEATAEFAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7E5</accession>
    <name>A0A2S5B7E5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7E5"/>
    <dbReference type="STRING" id="741276.A0A2S5B7E5"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="42873" checksum="67EEB90230A88B13" modified="2018-07-18" version="1">MRRNRLNWHVRRRQFGSRQLAAKNHLVAAIGEYVGTCLFLLFSLGACNVANMANTSVTGQLQAGQDGSAASTANTSNRNQRSDALPSDISFGFGISLTVTAWCFFRVSGGLFNPSITLGMLLVGALSPLRAAILAFVQILGGITGAAIIDALTPGTLNVRTELAPGMSVARGLFLEAAMTALLMLAILLLAAEKSKATFMAPLPIGLALFVAELASVYWTGKSLPSTWYLCAGGSLNPARSFGPDVVLHSFASYHWIYWLGPALGSTVAALFYRLIKFLEYETVQNNEEEGAAAVTPAQLDPMIETGEEVVEPQDAVPIEVTGFGGGLLESEDVQPTAAARAGPLAEPTDVSDKIDRLEGMLGAILQHLHIEVPAGASSEELRLSGETVSSTDGIRDGKEKDAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7J1</accession>
    <name>A0A2S5B7J1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7J1"/>
    <dbReference type="OrthoDB" id="2527194at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="115"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="548"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="793" mass="83453" checksum="096D90B272F770AC" modified="2018-07-18" version="1">MPRSVSRTAPPVPMPMSAIAIGLPDFSAFALSFDDLEMHPGTPSIPSTPCKCTETGGVPSGPSPTSLGPSPFPSTFSSPSGASCADANFDFFHNSGDVSHSTAASSDFFSTPVKPLASIAAVSVPHFSKTASKQWLFACRVVPTARPEDPAPRRARQSLGQMSLAGDQEPHTVWRSWQEFADFAASLLAAFPDDRRVPGSARLAPPVPRFSSKATLFTTRSSLVRRQEELEAFCQQLFRLPPDVCESELVRNFFQTRLGDHGGILSLRDANIVRPSLPAFATSSGSSLTGLSVDGNRRPSRPVLALKMSTPNLRFAANGGSTSPSPFKQCEEPAPSALPSSSKPLRGPVGTAHASVRPAEGAGGFAKSLRKKASGSLRSIRSLGDLRNAARKAPPAPPAHEPVPALPTAFAAAAATAAPAMERAQTQPVLALSARVSSTSGATRACAPTLIATARMGRVPSAPGSAPLPSQHRRTGSVKSTASSIEDLWGTPSPTFRQTPSGRVECMRPEEIARTIDSRRQSASFIAQLPQRTASTGSLGPSRAAGHRSSASTSSIDSIRSSASSVSSMARSLSRSSAGSDCTTPPTPPAEWSTSPAATAIRCEPEPVPPLPFFPVPPSMQHPHAAEHMTPRSSTSSFANASYGHGLSHDKVPVTPRSRAASSASACSRRRSSRGGPTVLETIQSSPTQPPPSELGGSLPWTFKILHRDENIVLRIPALSTSEATPELSELRRAIRSKFAACRIALPEDGGDTEWGLAWQVPGGAIRLVVQQADLDTCLAESVRRKIVLKVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Q3</accession>
    <name>A0A2S5B7Q3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Q3"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="753"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="931"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="953"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="981"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1045" mass="116435" checksum="19546CB9E00B6DAC" modified="2018-07-18" version="1">MSADGPFAFGFSHQQEQATRYEEDTQRPGTARLSTRPSTSVGERPRPFGSAVAGGVTSSTSSSIAVAQGDRDHDSDKDVAPFAFGPPAAQMSDHQSYPGEPAFAYGLDALQEEDDDDDCGMFSFYPPRTAEEVPIDPGSNSHQTAEVMPPMLNHRVASFEPDTSRDTADDPLVPSTIRMLPSGSEQLPLSPAAAFALKVQAGLPEWAHDDGFSRRDVSTSTRPSTQRRARQTREGRGRGGDIADIQVHEQPLHHASRFPSSSDKDIELADSPSAIPLNELVHTLPVSSIDDDKKEIASQPRARSGMRRRPVGVRKPDSDELEDSPYPAVQGSVSNIDDHNAAVLTIRSWVLGFFFCVVFSALNCFFSLRYPAPFITPIVTQLLSYPIGKYLAKVLPSDKLHLPAWMHPYGFPEYLTLNPGPFSIKEHTLLTIMANIATSPAYALSYSLTTEKEYGQPQPAGFDILLVLTSQIIGFGAAGLCRRFLVWPAAMIWPQNLVFSTVLNTLHAELDDEEPGMPRFRFFVYVIVGAFCWFWLPGFLFTALSAFSWLCWIVPNNVVVNQLFGVSSGLGMGLFTFDWSQMVYVVPPLVIPWWAQVNIFVGFVITFWILTPIIYYTNSWYTAFLPISTASVFDRFGEQYNTSQVLTTDGLHLNETAYKEYSPLFLPAAYSMSYLVQFMLVTGILVHTALYYGPDLWHRLVTPHRNQDDDDVHMRLMRNYREVPDLWYAALLIVSLGLSMITVACWDTSMPPWALLIALAFAFVYFLPAGIVFATSGFNFTLNMMIELVAGYLMPGNPKGNMLFKVYAVQVSGLGLYYSQDLKLAHYQKVPPRATFFAQLSSVSVTAFVQVGVKRWLVASVEDLCSRDQAAHLTCPYVRTWFSASTIWGVIGPSRLFSPGQLYNPMLYCMIAGMVLPVITWFLSKRYPRSWFVYINLPVAFVGAMYMPPATGINYSAPLIIGFIFQYLIRHRNFEWWSKYNFLLSAGLDAGTVFSGILIFLTLQLPKGGNISLNWWGNDVYTNTADWAGTPLKTPPPQGFGPTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7S5</accession>
    <name>A0A2S5B7S5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7S5"/>
    <dbReference type="STRING" id="741276.A0A2S5B7S5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="201" mass="23464" checksum="38C7D473D59CA8FE" modified="2018-07-18" version="1">MRSYIPDAEWKRLHDRLALPSQDGLYDHESSRPRLQVAVLDATSRFAFYKPHFSLGQAVGTARRLGAMRTVLTGIPHGHTHKTWYKWCRQFSRHQAPAGEMPHLWWDWPEETKRAPYLQYSHGDQWAAENFFRHANESVRLWETEHAVHEPTGELPRLHGIDVRPAFDGMTFSWAPWRNGQTNTGPSEQRVKGPRRHSSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8I9</accession>
    <name>A0A2S5B8I9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8I9"/>
    <dbReference type="STRING" id="741276.A0A2S5B8I9"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="307" mass="32801" checksum="3C7D349B3F0A806E" modified="2018-07-18" version="1">MSRLAHLERAVDRLTPLSLAEKSWDNVGIMVEAPRRPGQTHEPTKRRIVLCNDLTTPVCDEALSDPDTFAILTYHPPIFSGLKSLTLQTPLQASLLRCIAHGVSVFTIHTASDNSVGGVNDFMGSGLLKAAGVETDSEGMIRPGTGKGLRAITEAKNVPDGQEGAGGGRIVDFLEGGGRKLSRSEVVQAVKDRLNLKHLQAAWATTGVQDIQTVAICAGSGAGVLKGVPADLYLTGEMSHHDILAAVAAGTHVLCCNHSATERPWLHYYGPRLERALNEVGKEDTDAPFEGYEVVVSQADREPLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8S9</accession>
    <name>A0A2S5B8S9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_3513</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8S9"/>
    <dbReference type="STRING" id="741276.A0A2S5B8S9"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="44"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="252"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="340"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY73180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="535" mass="59626" checksum="E0992209D58C0C13" modified="2018-07-18" version="1" fragment="single">MSTSKSKKPTAFAALEPALHPLLLRALSSLQFAVPTPIQATLIPLALESARDILARARTGSGKTLAYAIPVVQGILQRREQGQLQGTRALVLVPTRELAEQVRGQIGRLVDGLGLGDAEGDRIRVVNVVGEQGGRKKRKTTGGERVERMQLADRPEIVVATPSRALAHLRSESLHLEHLDYLVIDEADLILSYGHSSEDIRSILSGPWNLPKVYQSFLMSATLTGEVEELKGVVLRNPIVLKLEDDEDELANLSQFCVRCSEEDKFLLLYVILKLKLIKGKCLIFVNDTDRGYRVKLFLEKYGIKSGVLNAELPFNSRYHAVQEFNRGVFDYLIATDESGLEGHDRDTNEEEEKDGEASGLISTQPAGADSTDGADVEAAPQPSKKRKRKEASSKPSTTEYGVSRGIDFVDVACVINFDLPFSSRSYTHRVGRTARAGRTGTSLSFIVPREQWGKQKKNDVSLETAKYDEKVWARIEKAQKTKAQEIKEYKFDFKQVEGFRYRMEDGLRSVTKAAVREARIKEIKNEVLNSEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8V3</accession>
    <name>A0A2S5B8V3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8V3"/>
    <dbReference type="STRING" id="741276.A0A2S5B8V3"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001070">
        <property type="entry name" value="Dynein intermediate chain, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="634"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="679"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="847" mass="89871" checksum="3633A3AAD11AB43A" modified="2018-07-18" version="1">MSSHSASISSKRAGARAAVGADRNRANDGGGVGSKGKSWLYWARRAARPVRLAELFKFSGLVALIRVSERRRAEIQEKRNRLAALKAAREQREAAARQALDASLSSATDDGAPPLPGSSRAASESAGERNGKASLGAASGTSRGDEIENLLRGVGVLGRDSAPPSPKGKEPLLRGSSPLATAARNGAEGTASPAPAVVENDSPEGTPNRDQAGAAGAPSLEAPDPASTATAPASSSTSTSIQTEPAPPPPLPTAKPKIVYDKAIQTAFDSESTVTRLNATASTSTGPSVTSGAEPSASTGGAGRETAEELRARILAELEDERKRLDAEIAREKLLAEQALERDRARGLSGDQLQHVFASPAFADFLEQSTKVVQRALSDPYDYLRDYSISADDGADADESKRARVRLLGVWQDQQWGRGRSVTSVDWSPKFPELFVAAYNRKPLSINEPDGIAAVWNLHLQDRPEYVRTTFRWLSMDQLLTCWISQSDILSIAFSPFNSNLVVGGTYSGQILLWDTRSRNPNPVLKTPLSTSGHTHPVYSLAHLGTQNANSLVSASTDGVVCAWSLDMLARPQETLELLHPAHSKTDEVSITSVGFPLGEASTFWCGTEEGNVYAAHRYDRAGAKAGLVQNEVYRGHSGPVTGLDFHPAEGSVDLSDLFLTSGVDWTVKLWRAGGANPARTAAGGAGSSSKVGTPTNGTGASSTRSGLSSSLGRSASGPPPPGTIAPLFTFEEAGDYVYDVRWHPVHPAVFGSVDAAGKFNLWNLNVDTEVPLVSTAVGDPARPRGLNKLAWEKKEGRRAAVGSSDGKVYIYDISPDLVTPREADWDQMRRTCKAALADQQNPDAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B912</accession>
    <name>A0A2S5B912_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B912"/>
    <dbReference type="OrthoDB" id="2537073at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="302" mass="31022" checksum="A15551D430D58109" modified="2018-07-18" version="1">MLVARSPSSPSSGSPFFARDYALIASTASAAGSSPRSSSPTAGADQTQRRPEIPRRPSALRNRSSDHILVHAKLRFGSSDSGAQAAGNAASGVTAAADQPQGDPPSSSGQHVQSEEGSAKPARSARRGSMSVGSDVLRGSPALCGDFTLSPPALQRRPSLAPLTPASPSGEEGRQRSLSTSSSGSGVSAGGSLLARRRSSRSAARPDVLAPLMTDLALADLPKLDDTVRPEVIGVSSYADIPASETTSPVDMTVKTASTRPSLVECSFRSTREKVSTPFPKGREEWIEAADVSADEAEAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B925</accession>
    <name>A0A2S5B925_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B925"/>
    <dbReference type="STRING" id="741276.A0A2S5B925"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="20050" checksum="5FCED16351B4C361" modified="2018-07-18" version="1">MALSHSLTRHSAQMDKIKERLASLRAEADTASERAEQAEAANKKLEHELMTKDQEITSLQHRIANLEADLEKAESNLSDAKGAKEDVEGHRSANETLTRKVVQLETDLDNAEKQLRETTDKLRQVDVKAEHFERQVARIEQERDQWEKKCEEAQEKYNKSQQELDELARAMQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B995</accession>
    <name>A0A2S5B995_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B995"/>
    <dbReference type="STRING" id="741276.A0A2S5B995"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="55"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="534" mass="58734" checksum="488C013643AA8E44" modified="2018-07-18" version="1">MSSLARRSSASIRSRTAHAVQMNGKNQAAAPVERKAAAASTSASTSSQLPSSSGRRLCLFFDGTGNAAFLEKITNLPTGFGLACNEPDKQLLYYQTGIGTTSLNLSAGLMPSMLSKLWARISAVVDEGIAYSLPAHIQRGYQFLMNYWQPGDQIFLFGFSRGAYTARALAGMLQRVGLLPAGNEETIPLAYEIYKKDRDLDEGVEKESAARAFKRTFSREVKVQFVGVWDTVSSVGAVIPRILPFANGSSYIRHFRQALALDEHRARFAYQPWIASDEPVPADYSIKQVWFAGAHSNIGGGLFGYDGDREPALSHLTLRWMLREAVEAGMWLNEDHLAASPIYAPFVEAADRAVAAGDDPALEAYLAKVAKSNPDMPPETAALAFIAASKSAATQDDALAPRGDSLSFHIQEYPPEIKKKRGLGGRFKDWWSRQMQRVGAAAWWALELSPTLKIYWDIEGNQRTWTLRWNRARGRVLLPDPTFHFSVADRLAASPATLLEHGGGNNENVPETKGYDFKAQFLPGQSMKNVTYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9N0</accession>
    <name>A0A2S5B9N0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9N0"/>
    <dbReference type="OrthoDB" id="5277092at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="107" mass="12030" checksum="A4169713386CA97E" modified="2018-07-18" version="1">MDPRVPSTQLSPEEQRPIDAFVQASPNSNYHIVEPVKGEPKVQLCRVSGEVTAPGGAQRRECTQIAQDVTKVFAFMSERGFFCQLPFDPTHTEIECVRINKIVQRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9R0</accession>
    <name>A0A2S5B9R0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3445</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B9R0"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="16"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="259"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="11">
        <location>
            <begin position="457"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="838"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1293"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1309"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1356" mass="147858" checksum="12F4EDA5CD3F0A1F" modified="2018-07-18" version="1">MASASQLVPRVYQHEAASRALQQNTVVRADTGSGKTLIAILLIRRVLSRPTTDRSLVVFTTPTTTLVAQQAAVVREQTTAKVKAFIGAEVEFWKRERWQEEIAQADVVVCTPQVWLNVLGSGYFRLRDCALLIMNECHHCTKKHPSAEIMRQHYHPAKLSDAEHVPKIFGMTASPLWNAKTPTKAIADLEALLDARILEVQAVHSAEVKQYTPKASEVLVEFETGGDLSTISRELDAARVLSEEVETRSLPTVDKLSPRVTALIDVLRPYEAHSGFHGIVFVEQRVHAIQLAELLVQQDSFADWLRPAALVGHGRSGWKEEDDGERERRLGMEVKEQQNIVARFRTGELNLLIATQVAEEGLDFRACNLVVRFDALKTVTGYIQSRGRARAADARFVVLAARDSIDASKYREYVEQEIALQQLYAGRPADDELPEPELDDLPTFTTDKGALLTHQSAISTLAGFCQLIRVDEYTPLQKPEFVVSGAGVSWVAELQVPKTAALYEHHFVSSRLPTRRAAKQNAAFQACLALHAAGVLDDHLLPLRPSRSVDAKDADGNALDRSTVPAVVQLELLNPFGNVWNSAESFVFVFEIALETPIQLALICGAEADLPSTPNAVLLLSRRTLIWPGDVGREQCLAALEKLNRDLSRIVLNRRVGEERFYALWAPVDASGEIDWPRVTAPFAPVRTDQLAAGDIVALPQLRTTTRLGTFSRVRSDVTSGSPTSDIETSPSKKKQKLVERTKYGHYLRTMYGDAAGEVGETEPIIAMEPIEFELHNALVSTRVATGASTSDVSAETAPSSRFFPLSLLRSTSLPLSFFRAFSYVPSLNRHFMEHAAIHALRATIDLPAIDDAPLRTALTAPNSQTGYDYQTLEFIGDAALQLATSVHVFLRHPKADEEHLSVMRANSVDNRFLRRLSLDRELSRFLLLHPHRPTTYVPEMSDAVTVSADGLALTRTAGRRVLSDTLEALLGAAVTSGGFGTLLHAAASLSLCAGGREDWNTRSNARALFDVPPRAAGPGMYALEAALGHTFRTQGDLLRQASTHRSWMENAACYERLEFLGDAILEWWATDRLFALSRTAPPSQLTFARALLVSSGALALVGLRKLELHKSILHSSPALERALVVAADEAQTFTWQQVVDGDLTFLWMPPKVVSDVVEALLAAIFIDAKFHLEPVLYVLDRLFADIMPLVVLSTEVRDPYSRLLMLAGSLGCSRLTVTVAFEEGSGGPYVATCTFHDEIIASISNSAKSVARQLAAKAALEQLAQPDIVACCGCKAERAAAAAAAVAAGASPSEVPTVDGNASPFNAAETTEPSTLIPTAPFPSDAHDADAISEDASDANAISGDANDANAMSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB59</accession>
    <name>A0A2S5BB59_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY73988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB59"/>
    <dbReference type="STRING" id="741276.A0A2S5BB59"/>
    <dbReference type="OrthoDB" id="3365245at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="55094" checksum="C2EC3504CEF0279A" modified="2018-07-18" version="1">MAFGFRPATPGTIVVLAATVLLVLVSVSVPITKSIWFLKANVQVSVDGIDINGVVTLGCWGYCISDNCTSSKLGYNLDILKLVGGSGSIAGVSTAVLKWITYLLILHPIAAALAAVATILGLLAHLRGFGATCFTTCVASLAATVALLAFVFDIVVFLIAKKRIEAAASGESAELGNAVWMTLAAMVLLLSSGFFFGCGACLIRRQRHEKQVSDLYRPQVDENYGSKMRNDAYANTNKNNVRASGNLPAFAEYEHERDLEKETEDQFGSGGYANQYHGAGSAAAAGGYASRPNQQLRFASTGAQDYSYQNASSGGGGYAGDMVGAGAVGGAAVAITGAGARLAAEARAQRGLATQEDLHLLNQEPAHGADRTLHHQSSVEPFTGMYDPTAQSRSEHEQQDSYSASPYYNPSQQGGGASMYQQDRPTSPSRLVGPRPLSAGPAQQQQSGPRSPTYSAGQHSQQYHQYGGGQQSPTYGSGAYPPYPVPEHQSTSPPPQQHYYQQSGNGATDMYGAPTRSYDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBA2</accession>
    <name>A0A2S5BBA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBA2"/>
    <dbReference type="STRING" id="741276.A0A2S5BBA2"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="239" mass="25463" checksum="69E7570C9A73D203" modified="2018-07-18" version="1">MSAHDTRPLPPGWIEQYDQSHDRHFWVDTNANPPRSIWTHPLDDPDYQASQRSNGFAPPPGPPPSHPSYGAGDHKSPLPQSSSYSSAPAAQSPGVDSNRYSSSSSTAQQQPQKKSAGGGFFGKIKDKVEQKRVESQQRDEQRRQMMMQQQQQRQQMMMQQQQMYGGRPGMMGGGGGMMGGGGGGRMGGGGGMNPMLMMGGGLLAGGLMGGMIADSQNDAYMDGYQDGGDGGDMGDMGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBB3</accession>
    <name>A0A2S5BBB3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBB3"/>
    <dbReference type="STRING" id="741276.A0A2S5BBB3"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="99"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27070" checksum="68BBB7F01EEF1F19" modified="2018-07-18" version="1">MPPSQPLTIFSARVCPWAQRATLALREVGAYEDGTLEHVEIDLQNKPEWYASKVNPASKVPVIRVGKEDAPGTLNIPESSVNLELVAELYPEKKLSPDDPVKRAYARYFAQRFHEVLTANYMGALFQGKPEATDSILTGVEEVQTLLTKFDGPFLLGNDISIGDLAVAPFVGRIFAAPKYDLLPADFAQKLEDPKYKVFRDYKEALTSRPSWEATFDEKYVMSHMKTMIEKRRAAANAESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBD6</accession>
    <name>A0A2S5BBD6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBD6"/>
    <dbReference type="STRING" id="741276.A0A2S5BBD6"/>
    <dbReference type="OrthoDB" id="2552042at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="315" mass="34177" checksum="C19C1C6AC97EF862" modified="2018-07-18" version="1">MGLWSRTYVCCAVPLYNGGIYAILAQFLIVSVVAGVLCFAAPSIVSVVTPDYVSYILGVLCFAVAACQPFGFFGVYRERPRLFKGFLRLNGVLVTCAVLCSLAIIIISAIKHSTAVDNCTALFSANSTDSTANTICNVWTWIQIGIMGLLFIIVGLCQIYFVSYTGIYASEQRLDHAKYDTVYSHAAEEIRASGLYDSQFNYATGRASYSQDELSDPHRPPYAEHGRQSSKSSGLRNELARGETQEYLNELEAGRGGAYGAGGGGGGGKLRKGGRPQSGSYGGEQGYPNQYDDNGYQDGGFRPPQQSSEMHRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBF0</accession>
    <name>A0A2S5BBF0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_2906</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBF0"/>
    <dbReference type="STRING" id="741276.A0A2S5BBF0"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="438"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="787"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY74094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="980" mass="108507" checksum="FD1C11ADBE5F86D2" modified="2018-07-18" version="1">MPPRRRASSSAAPASIVVSDSEGDDAAAASREDSTAPTSAHGTDNGSKLSTTEQAETSPRSGSARSTPRRSAAKAASKNLVLRKIQLTDSEDEEQVKLRELESGSESDVKPAARKGKGKARAISSSPEEEDDYSIKAEDDDVKMGSVSGSEEDEDAGVKKARALARKLKTTLESSSKSKGKGKAVDAAEVGKSVTRMLKGKGKATASSGASSPASFEVVIDKGGRRPSKKVAESRGSSVSNGRGRSTTASRRSTAAFLSSSDDESDVSDFAPSANAEDEDEDESEYDEDADASMDDVSETGSGGVPPSIDEESEDDLKPKKKKSKPTVKEEVLDELEQLDEEDLDGEEVAKKLKKKDRKIVPLRKGAVITKEDKKALKKMNNFGKTSFYLQANHPELKTCWDELTNLELRKVERAVQPEGLTQKLLPFQLEGLNWLVKQEQGPFKGGFLCDEMGMGKTIQTISLILSDWSPSHPKGSTLVLAPTVAIMQWKSEIEKFTKGFKVLIFHGTNRLSNVKEMEKYDVVLTSYAVLESTFRREQKGFTRKGKILKEDSILHKVKWHRVILDEAHNIKDRQANTAKAAFALRAHFRWCLSGTPLQNRVGELYSLIRFVGCDPFAFYFCKRCDCKSLHWLCTKGPCSECGHSAMQHTCYWNHEVLKPIQFGGATSGEGSRAFGKLSLLLQHLMLRRTKVERADDLGLPPRIVEVRRDFFTEEEEELYQSLFKDVKRKFNTYAHEGTVLNNYSNIFTLITRMRQMADHPDLVIKSKTAEPVQHAAADLPQEILTCRLCLDEAEDAVTTACRHLFCRECVRQYLETAIEFKPECPVCHLPMSIDLDQDAIEVDETGRQGFLARIDPTKARTSTKIEALLEELSKTRTEDRTLKTLVFSQFTTMLDLVARRLQLSGFKFVRLMGSMTPLARDNTIKAFTEDPECTVFLISLKAGGGGGTPQSRRVAFCPRRGLAGAIQRIFVRNTLADMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBI8</accession>
    <name>A0A2S5BBI8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBI8"/>
    <dbReference type="STRING" id="741276.A0A2S5BBI8"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="69" mass="7484" checksum="E66B0041F4863E7F" modified="2018-07-18" version="1">MDAVKDLADNSKTFVKDGQAFISRCTKPDKKEYLQICRAVAIGFAMMGGIGYLVKLIHIPINNILVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBW9</accession>
    <name>A0A2S5BBW9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBW9"/>
    <dbReference type="STRING" id="741276.A0A2S5BBW9"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="520" mass="57639" checksum="DB2FB157544EA067" modified="2018-07-18" version="1">MQDFKRNDSGSLEKLEREHIDYSSGAVAEVPTLTPAEEKRLVRKIDYKLVPFLSLLYLLSFLDRVNISQAKLDNLEKDLKLTDHQFQITLLVFFVGYVAFEVPSNMFLKHARPSRVIPACMLMWGITQTLMGLCTNFGGLVAARFCLGIAESPLFPGICYYLVSWYKRDESNLRVAIFFSSATLAGAFGGILAWAIAHMGGIGGKGGWAWIFIIEGLMTVVVACIAPFLIQDFPEESKFLSPKEKEFVLYRLKQDTGAAGNFRWAYAKRAFLDWKTYAMALIYIGVACPLYALSLFSPTIISKLGKFNRPQSMLLSTPPYVLAFFITLGSSFASDRLGQRGIFNVFWMSIVCIGYTILLAINVTKNPGVAYFAVFLCVGGIAPCIANTITWAGNNNAPVIKRGTAMGVLFMTGNSGGIVSSLIYRAKDAPKFRMGHAVCLGFAFMAASLSLFMRIYFAAENRRRDAKYGPLPKTVIGANGVETSAVRDDPGLRRKYGLEGMSEDEIDALGDKSPFFRYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC24</accession>
    <name>A0A2S5BC24_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC24"/>
    <dbReference type="OrthoDB" id="2534364at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015504371" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="48175" checksum="27A6A03DBE99B1D7" modified="2018-07-18" version="1">MVLLFAFWFLMGRARSWRGNPRELCDALHQPGRLLVNLTSPLHTQWRPLDEKGCAPLPAYLPALWTLTHGEDRLPPQYQASIFSKEYRQVAAEPLSETDAPRSRLDPIPFLRKRRAHPPTVLVVGDSVDRNGLVHFCQLFRRNVSIALYHDINDYPPGPYPPDLTRGHGPKYKGWDQRGLLHRCEIPFANGDGVALRVINGFHYGMDALDEFNSPDHNDWHAPGRIERRIDELFVPAIKQLGGTDKVDVVQLHSGMWDLALFGMQDDKTRWSLTIPLTPEQLAWWQDRMRHTIGHLRKTFPRARLVFRKLHRTDDAVQGTQYITNCETPLGFCHLARARVLTLGFLSCSLRHLQEEVARSEGLPIFDFGHVLEGYQAFQEKVHPLLVPGGIVYAHNLVNQLRIALESKDSWRRGWLWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC57</accession>
    <name>A0A2S5BC57_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC57"/>
    <dbReference type="STRING" id="741276.A0A2S5BC57"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="758"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="951" mass="100398" checksum="67A164B1C415B239" modified="2018-07-18" version="1">MAQSYSNTTSPNNYLIPSPSMSAAGGLAGPSHSNSTPAGNSAVFASSTPLSVQAGTPVTAVANGVTNGRRRSSAEAQLDHFAADSPPPEEMDGIEEEEEEQQRAEAAAVFLGGAAAAHTHGSTNGNGHASTSAAAAAGDAAGRESDKQIQKKKVKVGARASIACKTCRKRKVRCSAEWPVCRFCSARKLPCVYEGHPAENGGPVAAGPPATWGPAPTPATTLEAELPPANILLEALEAFVTHHYDTFPFIHRPSLTNEINDDRAPKELLACILALAARFCAPLRDLHPNAPSAAAEHYAQLAAHLLTLPETFPGQATPPPPTADMPISLMRCQCHLLLGFYELTAGRDNSGWLKIGTAIRMAQTLRLGFDDEVPVYDEDPDADPDNPLSTRGRAIAAAQQDPIRAESRRRTFWALFLLDRTVSDGNERPCGLKVPRIASLRMPGSDADFFAGRKSLGARFDPDPPLWAVSALNRTTGAASANATAAPSPAPPAEEPEADLFGYTLRIAEIWSKVASYIGSGGRNVDRRPPWQEDSTFAQLAKELTDFEARLPEELKYSQRTLTAHCLVPEDAKHFALLHLVNAMARHVLHRDYLPFLPPPGFKAAKGPVDGEPIYGDAVAPAGWWQESFDMAAKSGNVISDVCSHIFSHGIVLTHPFAGFAAVAAGTVHSHLKYWPQSSSTPIDATHYLNQDAEVLAALRNICTCPLRHPLSNPIASRWYDSLAGLQLLYFNLARGVIDADPFKVRAGVLQLLRSAKDDADVHSPTTTNESPTPGLAAAAAAAAKAASKPTAPLPAKKKREKVATKKESATSVKDPARSTAPTISNIVNPPSATTETPGTDDTPIDHGDHASAYYFPPPTTAGFPFPFAPATDFATLAPEFLPGDFAFDLPASASSFTAALGGTLDDWSQGYGNWGLAGFGGLGAGGVPGAVGGPGPSATGMWDGMTWNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCW9</accession>
    <name>A0A2S5BCW9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCW9"/>
    <dbReference type="STRING" id="741276.A0A2S5BCW9"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="3">
        <location>
            <begin position="100"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="302"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="909"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1034" mass="110273" checksum="828E720BFC383F20" modified="2018-07-18" version="1">MDATSRTRSAQPRPLDSSSSSAMVREAKGLAIELKALLKRREPWDRDLEFQRESLRKAYLRVIFAGGSEPRGDDRSLADRPRTVSSNSVATVSSNRRLDTLNLLWLDTTHALISSYRARLAELDKQIATAPKAHKNKNKDRDQIGNGGEVLPAAVGPVARRKLVHSFRQFLGKEEDFWRTLCGRFASRLHPEEAAELRSVGIIASTFYSSHDAAPVSERVARPPLEGSEIADEDREALRASVLPLAHKALICFGDLARYSELYSEATSPPVIDSGRGRGRGGKRGGKTAATGDRRIKTYTRAAECYNQARLLIPDNGNPSNQLAVLAQYAADPLSSIYHYYRALCVRTPFATAKANLKITFAKAVARWFSPEGGEPDGHDGERFKAAFIILHGVFFTKEKLSELPTLSLRLQELFRNVISERLLTSDVIVKVVTTSLAALWDARVSRSSLTRSKNGSTILGGSASAAALGASANSSSISSRNLEPHILLHVLSLLHLLLTRSTIETIEILGANEAQRPDDKGGVPATQNISAVLRRALPAVRILTKWLVSQLDYVARVEARVEASERRRHRTSNGEEAQQQSLESSASRESGDPTHVSLDEFRASLDALWIAYADFANVLNVAFPQAGLPLDLLDEGVWLEEDVELLGFVPLRRGMKGGAGDSGSISSREIRRVGRDVHPNDEHLMRVADVLRDARGLAGSQESRLEWQDCVFSSSHRHGQDEGAVAPSSATAPPAAEGIEEDEEMLDEATEDDPVDRAMRVATAAKFDMNDYTSDEDDELDGEEIVYSGNRSANLLPARSPQAVFAASPGANAALPPAAGDLRHLLLSSGGAAPPIAVPVSGRDAGFPSPLARAATHPSLPNIWAPTAGNGGSPVLGSGAFGAPSPHAQPVTPNSFEAIPNLTHGSSAAHAAGWPTATGGALPPPPGVSSSRNESAFAPIAAALSRPAGASPAPPPGMSRSAAAPPGLGPVSARPPLQAHASLPGPVSAGEVPRLSTAFAGLQRQNSDLSPFAPTFGARWGSAQGQSKSNGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCY0</accession>
    <name>A0A2S5BCY0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCY0"/>
    <dbReference type="STRING" id="741276.A0A2S5BCY0"/>
    <dbReference type="OrthoDB" id="2588793at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58278" checksum="1E06E37564D3B1E0" modified="2018-07-18" version="1">MSVSLPSYQRIPTSSDADSKPLPARPAASGPVASSPHLKQAASAGTAATGPTPRVRRTLMSIRRNQLAVAACAGLLVLTLLWGNRSDSPSSSRSAKTASSRKATTPEWSCNPFEANGRLQYDPDVQENNVWVPFDSRCKPSNMMSDLASSHGKRSATALPWFANRTIVIHSDSIDRYHLRDFCDFVGGKLTNINPEHPASPPMYRDPAADAERRKLEDQWSKRPTEGWELTTPWVCDVQRYGATLVNVFTFGLEGAESFFQSERWYYPPARWDDRLEEITLPLLRKIASHFKRPQIVYPDLVVLNSGYWDLRRYTEEDFVAAGFTSRPYPEDSPIPYTPLSDERMQRWEREARSAIKLAARSFVGEKSRKAKDGPTLLWRTLHHPPRHNYAPFPRVEALDSLSRKVVSDLRASQDLASSLDSAPRPPSRSFFSSSPAARSLTEGPSPPLDPTLAWKEPREPEPLGLERRLRIDNSGRLMLGQEHLFRDLLHPLPMPGSWLWGSVVLYELKRAVEGVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD16</accession>
    <name>A0A2S5BD16_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD16"/>
    <dbReference type="STRING" id="741276.A0A2S5BD16"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="565" mass="61650" checksum="54DFAB56D68956B3" modified="2018-07-18" version="1">MQDLSNIQPYHTTLPHVTKDNWRQLAAEKREKRDKLIPAEWTLPASLVEQAGKDVTGVAQQSGILSQKELEITEIDEVQDLAERIAKKTYTAEEVTVAFSKRAAIAQQLTNCLTEIFFEDALKRARELDAILAETGQTVGPLHGVPVSLKDQFDIAGTELTQGYGAYLGRISKRDSALVALLRDAGAVFHCRTNIPQTLMIGDTFNHVFGRTANPHQRDLIPGGSSGGEGALIAMKGSIIGVGTDIGGSVRIPSAMSGLHTLRPTTRRVPYGHATNSMLGQESILSVAGPMARSLNSCTYFLRAVLNQNPGNYDATSLPFAFNEAAYARPPTEGKLAFGVMRTDHLVTPTPPIRRALETAIERVKKAGHEVIEFDVADFTSYRDLANKFYAADGGEDIRRVVSAIDEPVIDGVLVNEATATENVFALWQLNRAKEAMQQAFLDKWLATAKETSTGRPIDGLLVPPAPITACLPGNNRHVGYTSFFNLLDLPAVVFPVTKVDPSVDVLDYKPISDEDKTFVDDYDPKLTAGVPAAVQLVGMRWRDEELLSLGEVVANLCDSKNWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD69</accession>
    <name>A0A2S5BD69_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD69"/>
    <dbReference type="OrthoDB" id="2529281at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="524" mass="56025" checksum="92604F2BF451DC1A" modified="2018-07-18" version="1">MGDVLWRMDQLESEDRSSLASGTTKGADEARSAAAQLQGLDSPLPPDPDTEKEAASLVDLIASMAMHEELQNARSRTFPSPATTIESPAAAADAGDTSYFSWKRWYGTLSRNPTAGAPRSSASQDDVSQQFRRAIQRAREAEASAASSCSSETYDHGFDSPASSISTWDTSASEADEPPTSVREAVNGPTQPRSVKPGPSARSLRATQSVATLKAPRSLRKTASCASLSSTSVELPPISPYSPSSSTCPTATPSASNLREAESTPLASSTGSSFGSRLASSLRRSASSFTLRRSATSREATSEPVPPIPRSLAPSQTAADRLRDLLMQHDAVVDPSLEPVTPLFDPRLARRNRQQSDSDGSSSEDDHDSSPDEAEEALEVERILRSISPEQRSVFEGDSSDDEDDDPFAPSAASRLAWMAPTTPEQGSAPHFGGPEPSSSPFTLETSAIDSPSRAFAPFDPFAFSLEHISGPELPPVPPSPPRRPRAKVVTKKRSFIDPRTRKICTAPQVTVTPSTPERQRTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD75</accession>
    <name>A0A2S5BD75_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamB/YcsF family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD75"/>
    <dbReference type="STRING" id="741276.A0A2S5BD75"/>
    <dbReference type="OrthoDB" id="5295431at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27250" checksum="5B4A9BD863A75C6C" modified="2018-07-18" version="1">MPLKATLNCDCGESFGQYSIGDDEGLFPIVDIANCACGEHGGDFNVMAKTVKLAKANNVKIGAHPSLPDRQGFGRRKMFLPTEDFFNCLLAQTGALAAFLKLNGLEFNHFKPHGQAYLMSANDLEMSRASARVAKLYGVPMLGLPGSRHQEACELEGVGFIPEFYADLQYGDEGQLLGPASASERHQTTPDAVYERVRKMLETGTWQSVSGDKTLSFPEGIKEVSICVHGDFPGAVETAKAVKRAIGDVSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD94</accession>
    <name>A0A2S5BD94_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aspergillus nuclease S(1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD94"/>
    <dbReference type="STRING" id="741276.A0A2S5BD94"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF29">
        <property type="entry name" value="S1_P1 NUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015541055" description="Aspergillus nuclease S(1)" evidence="8">
        <location>
            <begin position="21"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44624" checksum="332AF78D5F50FAB9" modified="2018-07-18" version="1">MRTIKLLASLSLVFAPTALAWGAAGHEIVATIAEIHLVPSVLAYLRSDESRLLPAYAQGHLAPVAAWADAIRGIPEFRGWSGPLHYTGWEGDHPPELCAWPDAEDQHTHTEGEGEDHGHWNSEHDVLHAIANYTGRLDADPTDWVSLRFLVHFLGDVHQPLHLTSRERGGNGDPVLWEGRRTNMHSLWDGLLIARALRETTNYTRPVPSQQIEQALMGRIYDPYIRLLLWEGVRSWWRDALPAWLSCGSSHIETAYTSGENTGQLAFASPGSSVASRFMSDVVCPFVWASETHKTTCALGFPANYDDELAGSMLDRSQEDDVEIEGRLLEVGGNSPFYRKIRDTKAVERLLVQGGLRLAATLNTVLGPAAEQAGFRTSITKGGSDAAWTRDGAYFGWLKEAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD96</accession>
    <name>A0A2S5BD96_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD96"/>
    <dbReference type="STRING" id="741276.A0A2S5BD96"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="79"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="483" mass="53624" checksum="9E837C393E516DDA" modified="2018-07-18" version="1">MTSDMKSEGAAADGPQRFPAKVWASSNTSATTRRANRKHVMIQLAASFLNYAETKCEGLFADITCRLGVSASYVKKKQYKFERVVGTGAFGEVKQATWTPPKDNPHYADAQKVGGHLEVAVKVVRKKALKGDLEAIADEISVLSGLDHPNVVKLYDHFESRERYYLTFELASGGELFEQISSRGKFTEGDAAIVVRNILQGVRYLHEHHIVHRDLKPENLIYIRPNSDRLVIADFGIAKHLDDNETLTSLAGSPGYAAPEVLLRKPHGKPVDLWSVGVITYCLLCGYIPFRSSDTQQLIEECRVAKLEFHDKYWKNISDDAKAFIRALVKPNPGDRPTAEQALKHKWLVDSLNKEHEHDLAAGFKENWTPSRKWKQSINTIIASRRFAQAADRARAARETSASLDSTDDESAGFRTAEEDSGPDSPPVPRNAGEEGEQRRLSEIRQRELEAKQHERTQAGSAQAQPAGLGAVQQGVDGLSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD98</accession>
    <name>A0A2S5BD98_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD98"/>
    <dbReference type="STRING" id="741276.A0A2S5BD98"/>
    <dbReference type="OrthoDB" id="2526919at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="171"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="437" mass="46755" checksum="C5191E326DBD9CD1" modified="2018-07-18" version="1">MATPALPSASPGALPTFDSTIGPFQGITLYNDRIIVALVMVIDVLHSAFSMNTIYFWCVTHYADPQIIAYSPWSFTAEPILTGFMAAVALPATGADLGREQIVHIFYGHRVLTLAAEGDRSSRPLFFGITLLTLVQLSFSIAVGVKIIEFDREFARFASWIWGACVWLGAAALADLIVCVSYLYYLNRTSRAMAGPFERSSKAVIKVATVILATNGLSAITAIASHHTLVDRSPPQLATVLFGVFRDANWHAILQLTLAKFLALSLLIALNARTLLADLLGVDPGIFQSSAKRALPAAAGQTTTTRSKFSSVLLRSGPYGQAAEAAGFDGRPPKSPGPSAVFSPSAMVRDADGRAFPVKASGLGARGRDGNISDLDDLEDDLDDEKDEFGASSRGSYPVQSVAFEDHIEQSSAHSRTPFVRSESDMATPPHPYALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDB8</accession>
    <name>A0A2S5BDB8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDB8"/>
    <dbReference type="OrthoDB" id="2520744at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="588" mass="65134" checksum="567BB02943F4DD8A" modified="2018-07-18" version="1">MDRSRPSAVRPLPQLPPELWNMILREAFMTIAESAMPANDDATLGKVAWYRPPNPQVERSLVDAIRLAGPAGLPWSRSLLFRSVHLGRSVRTERFLKALVLERPGDPSSCGYLKPLVSHLSLDIGPYPLPPRLDGSQSTKSNDGITPHQIGRIAESLPRLEKLTVNTGQGGDPWLCGKYMIDALRSFGRTVRELEMVSNGLGYQNAAYIFAESFDELRTLKLKNLAPGWTVLPNFAGLTQALIQERQLSEPYPSFANLETLVLWDCALDPAELRVLLESLQPAVTGNSMPASEPTLRHLTIHRLKLRQVIQGVTRTVPFPPRDLISLISPLVPYLESLHLVLFDRDPICTRARGMAAQLPPPDPPRRGDPRPGDELVQLIGPNFRRLVLGGPYCVTSDRFFSALDLAANRVSTSATTLGPGYVHQLKLTQCADEGHGEGLTPDRFVEALDREWAQHSFLREIDIAGMQIDMLVPSETEPRPLWGKAAIALVINKVKTMNEERGRLNRGRAVPPSVALHVSDTIRKQAELEAEEADWMEKRANRRGSAARSLRKALGRARSRVRSAQRRCEGEIGLGGPAAVSWGMWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDG7</accession>
    <name>A0A2S5BDG7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDG7"/>
    <dbReference type="STRING" id="741276.A0A2S5BDG7"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="441"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="864"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="906" mass="97148" checksum="A92EA39324629BB7" modified="2018-07-18" version="1">MPGGSDEDATAPESLPDLSSLAITRDDAPVVIAANDEEPTTTQDDATPAEVPQLSGEAEDVNDIWASVPRREGTAEGNSAGAAGGYHPGYTHTPPAPAIDLNDLDPFAPIQGTLGSTVRRESRLELMDNSESDKETNSPTEAERLRHEQEERLGQEQPSASGSGFSLGNMLRSLGGTPTKDRSASTGTPPPPPLPLPDVGIAEPVKASTSADSQPAVSSSPAQPGPSGLAKPLASIASVFRSSARPSPAGSDRGSPQPGSSPPREKGGFFAAIAGAGASAATGKGKEKERESVEKADDLDEKRSEEPLGEKGKRNKRGDEPVFDFNRFLEQMRSRSADPIAKYLRSFLKEFARRPPVSTNDQVRVINDFLDFIAGKMRQADPWKSLLDVDWRDDPERAEAEFDLALEAMEKLVMNRLWHLTFSPALDLAAFPGNMSPSGDVERDDVLRQRIRLFSWIEPKHLDLPIPSRLDTPAASTPEPGSPKVDERPADPPDSEATGSHRKPSPPPKPPASPSPAKSNRKQVQSFLNFAQSELCKMNQYKAPRDKLICVLNCCKVIFGLMKHVAIGEQGADTFIPFLIYVVIKANPEHLVSNLQYIQRFRNPEKLSGEGGYYLSSLTAAISFIESLDASALSNITQEEFEAHVAAAVKQIASEEPPPPVPPRDEKLRPPPRDPTATSSDLLQPTEGGGSASLLTAGDSSSAADREVVSALAQSASFPQSVRDSLMRGTENVERAMSKPLGALARIFEQLEETANEITGQTSSGQPRTMQVPPAPYPPTPGAQPSPDAYPGMQARPAVSKRRSYHQGGGPGLSPPTRPPLLPLPSSTGSLQHAGPPPNMAMYAAPDTSDDAVLQEIDRQHEEARQASLETLQSIFPEAEREVLEMVLLSNSGDMGKTIDSMLEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDZ2</accession>
    <name>A0A2S5BDZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDZ2"/>
    <dbReference type="STRING" id="741276.A0A2S5BDZ2"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="565" mass="62523" checksum="583304B3A6EA0C62" modified="2018-07-18" version="1">MKPPDIYKLVTLLEASETRSEIIKTLALAGDEEANKIIESLLPYLTLPTLLLLRKDRPSLGQVITDKLYNVVDAQRDWVVSADCPIDRRDSYLVRVFDETWDGLVKPGMTEIAGARQADVRAGMILDHRSPYRQNALQSCKDLASFRQALQQASGGLLDKLDWTNVVLAGGAVLGILTGQVRFSTYSASDIDLFLVGLQKDELLPKVRSMIQQIQVALASVLGKGMPSADFSPTALQAEYAELSRREPNVRQSAWADQFPDRLLILKGFNAITLVPPLGFEPRRPIQIVLNSAPTVYDALACRKGDPSAAVASGRALKYAQRGFAFVLPGPAKGALDGFGLKYVETVKRLRTDERAQQQTRREPDVTRLRTEDLAGLPGLLRREAIQRRRDERNPPPHSDDITLDYGYRTASWIKVVSQADLQAKANGQILREFYNYAAKDVAVSIENSLLTVDKAVAEHAEYIPGAPTKRHKGLQCPLGRDRPYADYVVPYVASFDRDFVLGFKADPADPYAQEWTQIRNLQYIIKLPKSLLPVLDKGSETMSALISEAILSSSDTLGGMSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE25</accession>
    <name>A0A2S5BE25_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE25"/>
    <dbReference type="STRING" id="741276.A0A2S5BE25"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="761" mass="82961" checksum="C6EEA23656740C56" modified="2018-07-18" version="1">MGTRREPRAVPFGPRDFLVRVASNWRTLPSNTASSPVNEPLLARTETGWALDTEDESRPSNSRRSAGSRTRRLQFGIDPDYVDEKDTAVNSLDRTRRWLVGCFVVILLAGTGWRIATSGQADLARAKSQWDAGVQKVQGWSATSSQPPQAGVAEESDGSPSGGGAELVEGEGAGGGADPLDSLGGNKASTGPASDGPPMRPLLESDDSSSAGKPGSSGSSLSAPAPLNVHPKPRPVDPATAAEQRYLAFDNHSGFHNQRKSLVNALVLAELLNRTLLLPPARLGNAVPWEPDPKHSLTFSERCKAGLESDKPVAPNPKSHLIGLEEACQPPSGWTYVGWEFLVSPSLFEDRDIVDRWNSSSSWLSAASDVGGLDIAPQDRHVLEDLYRRSYQVIDSSNTALDSHFASRLDLDSLRDPAGLGRKRLLQFGSLFSGSRLKLVVPEHRALYDQTFQQVVLQNDELDSISNEVRDALGSYVAVHARLGDGVFKSQAERNMQRLFQTLCVDVFGLSKAAATKLWKDARSPVKARPVHRVHDRRHLIGGRSPAPSPFRVDYASVDEPAERDEALAADGTIDIPSGQRSQGQGRRARQRSIDDERLEPRAPLRGGPARPLAPHLHCRGRLHDAAKKPALALLNTPLYIATDSHHPVNDPHLAAFFRWFPCTFVLGDFARAGRVNERPIEALAQLASRESDQDTSVSKWTSDWDGSNLGNFLLPFLEAEIAARAVRVLGTHQSTFSGYTTTVLHDNYVQRGLVAPWKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE66</accession>
    <name>A0A2S5BE66_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2033</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE66"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="571"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="380"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="632"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="666"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="788" mass="83569" checksum="D7E42F5E3AC9548B" modified="2018-07-18" version="1">MRESNHSFPAHGRACICVSSGIYDRRALDAPTASLPLINSLTHLSYLTATSPRVREILAGDGGLERLVSILQQCAQGGAAAASAAGASASSSRLSGSLDRKGKGKAIDRPRPRRSPFKPFAEYSALPSMADIQVFEELGLPIGSTAPTTSYVDQPMPFALPPSLALPLPNKQRFLLHTYKLAFQCIVNIGVRGSEAIRTRVVEAGALDVVVYVLERYLEDVERRRLEASAEWRRQREITAAGAAFLAGEDAVMQVENDPLVPTFAVSSAAAGTTPTLALPPSTASLPLLTRVNVVAASSSSSSISPGLQPPSRVQTPDTVLSMDDSSVTGDENGSASGPDAEGDEVSMPSSSGSSSASTVAAPVPRCAIAERKVALADVDAGSDVEMRDQSRPESPAPGSSAQSTRRHARQALPRVRTAQTGLTASTLDSRAEFAASSAGSSPVSYDPAATAGTARDASNASGPLRFRDEDVLLSLQLLAYLSKYPHVRAIFHSSAVASLPLPPAHPCRSGPAGQQAMNVFSLVEAFTFKPASDDPFTPRHSSEVQYWAGVIMRNACRKDDARGGIRQCANMRCVKWEQYAREFAKCRRCRRAKYCSKVCQSEAWTQGHRYWCHKVASRRSDTVDVLSRSSAAADAHGSSAASTPTGASSGSEGLATPRAGEAAPSRRRHHSHHHHHHASSHGHTHQSARRRHRSAEEEEDDEDDLPLPPTIAVHDASTTPRAHPQRLPGGAPQFDLGPAEVGPTQTGLVPGVDEDHIAREMLRVAGGAGIGIGLGDNFDGVVRVQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEA4</accession>
    <name>A0A2S5BEA4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2528628at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="782"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="832"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1423"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1679" mass="178072" checksum="3390D6BF9CADBF35" modified="2018-07-18" version="1">MPALLAVPATTTTTNTTSRIPRTRSGTVVRARPVSGTDNDENAKPSTSRRRASLAGKSAGDSTRGKRRVVFTWITAANQDSAVPLMMPTPPNSQSPPRNKGLNAVAQRVEPADVGPASAKPSKLSRARPHAGPAASGSTTASTTAKPRRAPSRSPIPAGPSHAPHVLAARRRASVSPLPSNSTIPPPVATSSATLPKKSRQPRKKVVRPRPSELLPVPIGSPPPSQNREGGAGPDDDDSEADELLLLPPEMTRGRGEGKVRPPHHHYRYPTRAGSASASTSQQSSFSMRRSPSSEVVGGSSQPASLESREKSVKSEDSTAASGAYFAADGADRDRATMKAGMSFSITAPSSDAAFGDADPFGELGEVAASVDDQAQDNINAAAAAAEDGADMGGFDGHDYFEPDDYRAGASPEPTTAADLDGDDEEQRGDEDEMALEAGPRFADLEDASSGSELGPGDDHSEGELEHDVPENPEGDAPLTVESAASMRDETEQEAVTAAADAETDDIDDSDSSTDEAEPALDRSSYELPSHSARQSRPSYPPLSPTRTGEVDDVVPVRMESSSPEPESQPEPQPEQALQAEKEDESEEQIRVEEAEDVFGTAVTQDTSAENVKPSLVALSGAGSPRPFPLHGTPSASVLPALLRPSSFFPAATRSPSPAAFGSPNPLPSPAARPTLQFASPRLPRDRLASTAPSLTAQSMCATIPGSTSLAHDLSPAKIWTRGPAFFRSSSFSPPAHAALPKTATLFERHPGGRAARQRARGEPGAVEQSREYQPGAGLDTSSPSQSQEAGSSSMRRDLRGSEASDDDDDDDEEDEVILVGEESQALERAQSRSLSPASSASSAAKGPSQPVSQKDGMLSDPASESDRDLHSPARSISGDIRMGSPSPRQSTSSEREQPATLRETAGGAETDCRMASPSPARSEYSKAQGSPLRARFGEFVEGSKSRIQGLLFGSPQKTPAAPARDAPTSAKHVQGSECESAAENVNTEDEDEDDQAEQPFTDPKLHPRGPVSVADSTFSASRSMASFASSNASRRSRRRSRPSHPTLPVIEISSTDAHAAARAAAILKVYHKYVEQGVEAVDLERLVAAEQAGVAFDKSLAPGVVPGLEDDDEEEEELRTLLLDAEDEVREMVPRQPSVLANDILTDPYQTRAAGSRTIEAPVTVPTSWTSREWRRLEQALVEVGRKRLRASSVASAASTSVSMTSEAIAAASVTGEDVEPDEVIEAFLRKWRISNDALQADWAWDKLVIRVEALKARRAKDARTRRASTADSAQTAPKVRSRRRQPRELSVVQETADEVAAASNSEEELEVDDDSLVKLESSDEADADALTPVDERNFAETSSDEEDGANDETFFAPERRYRRRRSSIEPVHQPTALANPALRHLYDATPAPEKPQLPFNGIVRAAQPSADRKDEVDESGSDSGSPGTPETPIPAGEAGRSPSSASRLLSYLGSFVRRSPAVSPSSTRAASRSTTPESPSGPEMQQVLRGGGDPIVPLNFASTSGSFVAGTSQPLPPISDRKILPLPPSHTVDAALTSRASLDEPSFDTSLAGNTTSASSSFVPLAFRRRRRSSNSGERSLVWDVVNAIEEAESSREEEEARIVDLLQNSSGSLSGAGTKRRAAAGDLRGGDAKGKGKAVDWRGYVEIDRELERGFLATGLRATDRRVSGEKRATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEI3</accession>
    <name>A0A2S5BEI3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF431-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEI3"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25951" checksum="1BC2A00075DC9803" modified="2018-07-18" version="1">MLFPNRIEHMEEDNADATFPHWIALEYAQMLKWAAPNKVIFSSLSPASVKSLCNRARKASADSSSCFGQLAAEQLAARGVSPDSFRAETKSVTDLMKEENVALDKVCLLDPRATGEIAPQDGKEFEWFLFGGILGDDPPRDRTGILRAKGFPGRHLGPIQMTTDTALGVTSLVVQGGKTISTIQFVDHPTIQFDEHEGVEMPFRYVVDDKSGEPILPEGMREHLKADMDRGLDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEJ1</accession>
    <name>A0A2S5BEJ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Acid-D-amino-acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEJ1"/>
    <dbReference type="STRING" id="741276.A0A2S5BEJ1"/>
    <dbReference type="OrthoDB" id="2528866at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="855" mass="89240" checksum="F4D5915E33615525" modified="2018-07-18" version="1">MPRRATNRTARAAAQAAAPGPAASDSASRKRARDDDPDATSAPQPARADPALATESEPKRKRRKGKAKEEEKDDGEDEQDAAPPHLASRALEPESSAASSTLAASQSTQSPDEATDAAGEAARVAPMTVDPPAAADGNSLALDAMSPEQRRLAKGKGKAKDDSTASDEATAEQLARLQHDLTSRDEVIASQTAILASLHSAVTCTVCLERLDRPYALQCGHVFCRKCLISWFYRPKPEGQSTAGSQGGASSGSGTDSSSSSDSDSGSSSSSASHRVLVERARASRRARNAPSGSAAAAAGGAGSAQGDAESAAEAARRRQVEQDLWGDDPRAPTAAGTSTSTAATATSGASRGEPAPTGDENLSADALRRARLARFDSRRPDAAANEAPAKSEAAPGPMAGPSTAATATNVPASPPPASFPARIPTGAHRDQNLICPQCRAPCSMRAPHRIFALDEILSTLRRARVDEDGLRPRSASPVKSREDLQGKGKGKAGVGSKGDGDLVDLEAIDEKDQSWGGLFPGQGGTESAKDRRRRLAQVVRDRDDGVRRCGSCNWELDERTGICEGCGRQWDISSDDGDDDDDSEGGAVGSLAPFGRHRNLARQHRALSVSSDSASGSDEEDGSGSDRGARVGFSDGERSEGGSDSYESDFVVKSEEEEDDRQSRRRRDRPRPASSEDIDDDDEKETGSQRRSARSDVWNRRRSPRASASSGEDDDSDAEAKARRERKAKRRRRLQGEVIDPDSDSHSGGSSGSASGSGDSSSGDDESSSSSSESEGADAPRTTRSGRVIASTAPRGIDTTGFETSSNDGTYASANSADDDDSASASSSSNDPEPAPAPSPPKKKRVIAVSSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF40</accession>
    <name>A0A2S5BF40_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF40"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="307"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="612" mass="70305" checksum="A96DC6AE14E30A5A" modified="2018-07-18" version="1">MYDERTSKEELRPWDSDASLPLARSPDGAPTVRAWPSRRPAYWRTLARPLSWLAVTVVVGTFLLRATRNGPWRSSGAARPSELRSDGVYAYATPMLDGDLAYQEHPIHVLIRNAKREWADKVARQSKTYDEAVEEYRRRYKRSPPPGYDRWYNWAVENDVQLIDEFDVIMDQTEPFWALPPSVLLERIALYEDPEGFGRDHTVITIKDGKFTKTGGTWRDPVPGGFVLLMESVAKLLPNVKMPLYLHDASSVTLDWEAMDGYRKAAREGRFVNEDELPIAGETFWFNRDRQCAPDSAHRREISGLAIVPPIGGPPFIHDHFKAMSYCNDPHAINIHGATSGWPFPQVLRPSFALSRAPWNGDMVWPSTIQYDLNPKEESEFREKAHKLLWRGSLDGVGVGVADRWRQSHRFRLATLFNSREAIPRVVRETRIDSRGREYQVDETHTLAELNARYSNVRPTGGPVQCSPDVCEHLSKTFKFYGHATLEEMANNRYVMDVDGNAYSARFRAHLASNQVPFKSTIYPEWYEGRIQPWVHYVPVRLDYADLYNILAFFDGGIDAARTGNHDDLAEEIAYAGADWARHFWRDIDMQAYVFRLSLEWARILDPAREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF52</accession>
    <name>A0A2S5BF52_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF52"/>
    <dbReference type="STRING" id="741276.A0A2S5BF52"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="287" mass="30381" checksum="DD61B6DB669FF6E4" modified="2018-07-18" version="1">MASLKSMMAAKRAQHRITAPHAKYSSSGQLSCSLCGLAIKHESLWGAHVQSKAHRVHVQRVEAEQAKAAERASAKRRREDQDEDGDGDGLGEDGAKRAREDNTDSTDAAALPDGFFADPSEAPTAPSPSVSTSTAALAAVEEASTSASAAAAAGGTADDDPEWAEFEKYLASGPSNESGPSRSTATATIKAAPVKFEFGAPVVEEEGGQGNANGGATGGGGGGADEDEEEEETEEAKLEREMREEREEMMARLEEEEREQREADEKVSVLKRRLEAIRAARQKKKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF65</accession>
    <name>A0A2S5BF65_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF65"/>
    <dbReference type="OrthoDB" id="2524297at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="55822" checksum="3C0916EF21344EF0" modified="2018-07-18" version="1">MAHLARFTELPDELLRHVILLSASQPTDSTDPLAARRRRIQLESLSLVCRAWRPIAQRALIQPERPVELFHAKQLAPLVGLLSSSCQAIGNLVTALDVELWGETQDYQLVHTIRTCRRLETLALTHVERVRLDQVATGEVSVDLASLSLRQCTLVSAYYPDPPPEADRESWIPRSLLLPATFSALSRLDLRLCSLRRDFLPLSLLESSAASSAARPLLPSLRHLLLFTGSHDQSPATIRALVRSVAQQLHSLSLDYTAYEHLFPSLETDSVEPPSFPELRCYGTYWDAAYHALVGLPIAFPPPSAASKSAGVITGNVSRSDRPSRNAVPFLHTALYPAQLESLAAALESVLTNPELKAAHVWAGVEQWRIEGTLRDLDQTEDELDQEVEDEDEESIEGDGGAEDAPQEEEDFDATSPQSTPARRLRPHYSRTEALVQIARHEAKLDLRIEPAASSDDDAAELASQSLETHGLPATERIQRATFERGFGTSWWRFVDDVEQGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFD9</accession>
    <name>A0A2S5BFD9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFD9"/>
    <dbReference type="STRING" id="741276.A0A2S5BFD9"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8540" checksum="519E09B7BB85CE0B" modified="2018-07-18" version="1">MGGGLIFLVLIVAVGIAAGGFYAVPKGENQVVIRTSILLAVSCCWLMWAITYLAQLHPLIKPHRADYRPIKESLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFH3</accession>
    <name>A0A2S5BFH3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1412</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFH3"/>
    <dbReference type="STRING" id="741276.A0A2S5BFH3"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="92"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="295"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="392" mass="43729" checksum="58EF86D339664097" modified="2018-07-18" version="1">MGQLGSGLRAQNWDVSSLIKFEKNFYEEHPVVAARSEREVQEFRREKEIQVFGNNIPKPVTSFEEMNFPSYIMAEVKRAGFTAPSPIQCQSWPMALSGRDLVAVSATGSGKTISFALPAMIHINAQPLLSPGDGPIVLILAPTRELAVQIQEECTKFGSSSRIRNTCVYGGVPKGGQIRDLQRGSEIVIATPGRLIDMLESGKTNLRRVTYLVMDEADRMLDMGFEPQIRKILEQIRPDRQTLMFSATWPKEVQKLAHTFLKDFIQVTIGSLELSANLNITQIVEVCSDFEKRGKLIKHLEKISSENAKVLIFIGTKRVADDLTKFLRQDGWPALAIHGDKQQQERDWVLGEFKSGRSPIMIATDVASRGLVPPDVVYPPSGLPRGVIRLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGA9</accession>
    <name>A0A2S5BGA9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGA9"/>
    <dbReference type="STRING" id="741276.A0A2S5BGA9"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="289"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="524" mass="57731" checksum="84031F684F635E9F" modified="2018-07-18" version="1">MQTIDLTGDDAPRPTPTRRVTVPASSPYDLDAIATTWDTLGRNKVTRLLHVAKLSPSLAGPALSLALSAIKATTLDTRLYEESYLVYRHFQEALAKGEVTDPQAKAWYEQHAGGVDGASFESFDKAWIEKSKHEAQAGLDRLEIELKGYLTNLIKESIRMGHRDLARFQYRVGDLQAAIRSYTKSREYGSTSQHMLEMSLGVIEVALDMSNYAFIRTYVAKAESALESAQASASNNAKKSAAPVNLPGMVAPAQDPIEAAKERERKIVQERLLVASGVAHLGSGAYDRAAYSFTDVGTEALSSGTSHFIPPADVALYATVTGLACFSRSKLRTRILENPNLRPFLDLEPYLRDIARAFYDNKFKVGLDLLEKYQASLACQSPKLPRLQARLQLDLHLSPHVDSLLSSIRQRALQSYFSPFASVSLDHMSAAFGWSADSTQAAVIDLIQRGALKARIDSAKGILVAKRVEPRVEAFRNALDQGEKMQKKAVASQLRMKLLQNEIVVKPKRAPKDQDDGRVPMLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGH3</accession>
    <name>A0A2S5BGH3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGH3"/>
    <dbReference type="STRING" id="741276.A0A2S5BGH3"/>
    <dbReference type="OrthoDB" id="2530133at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="232" mass="24536" checksum="B0FE7E1DF899D2B5" modified="2018-07-18" version="1">MPRKPASATATSIEPRKSPRTASSNSITGKAPADVPALRSASWTSAAHLGSLFSSPSGKGIVADDTASTLSSSSSSVDLIDLASSSSSIASLRPPSTQQESAYDLHSTPIPAGALVLLDGKPSASSDVMPNPSNRSPAAVKTSAPVPPTSRMNGRQTRVWSGPKGKMPFWQRWRIWYGGVSVIQMLEPWECVLYHSIMLVALFAVFCALAYLPAHASVIVKRVQWYISGIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGH7</accession>
    <name>A0A2S5BGH7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGH7"/>
    <dbReference type="STRING" id="741276.A0A2S5BGH7"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="461" mass="50974" checksum="D89C385A21AD1F0F" modified="2018-07-18" version="1">MPIKLLQHKSWHVYNQENVARVKRDEARAAQEQDAQDERAFQAEAEARLDRLRTKSKRKRDSRDDPGEKELERQLAGKSRRGDGLADASEEGEREHARAIIVRPEGWEEAKDEHGRVKKPKKDDAPMTTNGHLNFWAELEAGAQAPASALEKRLEKVLAQEPDDSLTKVYLAKKGEGDPKGWYASSDGKTERERKEPVETTLERTYRDNESKRLDDPLALMNSYLKHRDHIKSGKPLPTPRAPSSRDRYIEPTATASRRSSAPSRLREAWDDTPRSSISSSTAAPAEAPKSFEPVVPRLLPPKHKRPSGSSLAAMSASDKDSKDLASATMRPTSSSSHAASRSAVDPAREASTRVNSERARAAALLASRRRAALAAASGSSDYSPSVASSPARSEIAGGWGMYNREEVLAARGKGGGRHSLGASGARERDAGGWGERKERRQERHRQSWHGCDRDSGYDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGK7</accession>
    <name>A0A2S5BGK7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGK7"/>
    <dbReference type="STRING" id="741276.A0A2S5BGK7"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21827" checksum="880BCC65E0FB95A5" modified="2018-07-18" version="1">MAAGWSELGAKDHAAAEGRVRAGRRDYLARPHDTRASDSTFRSSQYGKADPKGRSSVTWKQDPQGAVTIRTRKFLTNRLLQRKQMVVDVLHPTRANVAKDELRDKLAAMYKAPKDQVIVFGFRTQFGGGKSTGFALIYDSKEALKFEPRYRLVRFGLAEKKERAGRKLRKERKNRAKKFRGTAKSKADAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGM5</accession>
    <name>A0A2S5BGM5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGM5"/>
    <dbReference type="STRING" id="741276.A0A2S5BGM5"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="463" mass="48897" checksum="C8023FFD3841EC04" modified="2018-07-18" version="1">MDSSPSAALPRLVPVPSPTLLSEAIAALRSLLVRSPPIVNLSTLDALIDAQGTADGEGESADWDEFEFSYARDWLAQAVSVGTRCLARGGMDSESWEHVVDGAAALLADLSGPNAQGATTRTYLLPARPAQSRTGLLAPIPQKAALIAAALAFPTPPPTRPPSTAPPPASSDVSPPLADTLILRDATQLEASTGHRTWGAATLLARLIVHQPETFFPPSPVALRVLELGSGTGLVGLTAARTLGATGRNATVVVSDGGDEPEAVLDNLRYNVAENFADSPCGNAVSVRVEKLDWRDFVPLPTRAGCPPHGVPTSLPTPRYDVILGSDLAYERGQATLLHAAVAAHLAFPEENRHASVTVASRASAPPAFHLVLPLRPTHKVEMQEIESCFPQVGPTALDPISDPALVRVGTDGRAYRLSTAARREIVAPDGFDCSHGRRLARPDAGEMTYEIRRIQWVVVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGS0</accession>
    <name>A0A2S5BGS0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1046</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGS0"/>
    <dbReference type="STRING" id="741276.A0A2S5BGS0"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000011">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="13"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="10">
        <location>
            <begin position="313"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="71805" checksum="92509A711F30AA7E" modified="2018-07-18" version="1">MAPTAKRYAHTRALLGADLFDKVTDAKLLVVGAGGIGCELIKNLVMSGFGTGERGEILVLDLDTIDLSNLNRQFLFQKQHVKRPKAVVARETALKFNPNVNMTALHRNIKDQEFNVDFFKRFDFVINALDNLDARRHVNKMCLAADIPLLESGTSGYVGQVQPIKRETTECFDCTGKPVPKTFAVCTIRSTPSTAHHCIAWAKSYLFPQMYGADDEADSQELDDAEKNGENVDEIKELRKEANANRELRATLNSEGAAERIFKKVYIDDIARLLKMEDMWAHRKAPHTLDWQALSAAEASTSAAAAAKEGSEENAAAADGKSEQEQARIQDQRKLSLKDSFDLFVDAIERLTKRFDPKGEPLAFDKDDEDTLDFVVGAANLRAAAFDIESQTKFQVKEYAGNIIPAIATTNAIIAAALVHQALNVLRGSWSSARTIWLKRTPQRVFDVSPLSAPNPQCAVCRIVYVPVRVAADVTLGELVKELVGEGKPIPFEGVVSVQEGTRLLYESEDFEDNAGKTLKELGIDEGKFVTVSDDDEPHWPVQLCIGGALPADSEKRVEADTSAIPSPIPTRAPPPEPAADTDDEDAITVGGDDLAIVIEGAASTDPEAGRPGAKVVGKKRTADEAGLPEDADAGEKKQKKADDIVLEDDGDEVIIDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGS5</accession>
    <name>A0A2S5BGS5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGS5"/>
    <dbReference type="STRING" id="741276.A0A2S5BGS5"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="375" mass="40825" checksum="EC146E095957D6C2" modified="2018-07-18" version="1">MTDRISYKRVQASDIRRAFEIEKAGFPEDEAASLESLEYRQANAGNLFLGAYETQEHGGTPLLIGYVCSTATRSPILTHDSMSTHEADGPYIAIHSVCVAQTHLRKGIASALLREYLARLERDPAVQGARLIAHEELVPLYQKVGFELVGPSEVQHGARPWFELRRDFRRQAGAEADKVAPTSDKEGDVRSPGRLLGWFEGGIDQVVDSATGTNRVNLYCPRAECRCLLLRAGAGKYVQGTSKDLELPDLPRPISAPAPPTPSSKRGYWSVSSPLAFENIGFSRNALPPSSSSSSAAFGPVSSQGQQAGANIKYLTCADCDHGPLGWHDTEGRDLGMEVQAENEARRGGEGMASEAPVRKGREFLLAVERVRYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGX2</accession>
    <name>A0A2S5BGX2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0751</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGX2"/>
    <dbReference type="STRING" id="741276.A0A2S5BGX2"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="7"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="839"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1120" mass="122998" checksum="FAAAAB37493FF244" modified="2018-07-18" version="1">MSGIPQDRTRNICIVAHVDHGKSSLADGLLAANGIISSRLAGTIRYLDSREDEQERGITMESSAVSLRWRQPKQGTEAEEKPVLEDFKINLIDTPGHVDFSSEVSTASRLCDGAFVLVDAVEGVCTQTVTVLRTVYMSHLKPILVINKLDRLISEIKLSPIEAYHHLNRIIEDVNAVVGSFYSSERMEEDLRRYERSKAKGDAEADADAAAEDEPFEERDDSELYFDPAQGNVLFASALDGWAFRISRFAELYASKLGFSASNLNKVLWGEWYLDPKSKRVLSRKKMEATGKKLKPLFVQFVLENIWAVYDCVSLNNNPVKVDKIIATLGVKVRPQDLRAKDTRNLLLSIFSQWLPLAPAAFGAIIDKIPAPAAAQGFRIPRMLHPELGHLDDDVAPANKLERDMYSGSNADDAYRIAYVSKMFAVKTEDLPQNQRKQLTAEDMRARAKALKEAKEKKEAFIAEGKPDEAEAVMAAYHQANADALEEEKAAQSNGSDKEDALIGFARLYSGTIALGDSLYAVLPKYNADLAPSHPSNAKHLQPIKVENLFMMMGRELLAVKEVQAGNLFAIGGLEGIVLRNATLCGMGKDRQVKEGPQRDEDRGCLVNLAGVANTTPPIVRVALEPQDPSEMSKLIEGLRLLNQADPCVETLVQSTGEHVILTAGELHLERCLKDLRDRFAKIEITVSPPIVPFRETAVSVPDMAPPKTPNHPRGTIIGSVQSGLVTLTIRAQPMPAKVTTFLAANANTIKRIQRDRRSGKADDDADAATDVPEAAGVVSPEEFWPALEAVLQKAGREWSGLADQIWSFGPRRIGSNMLVDRTEGAPRSLRRRLERQAAIPSALQTPGGNSALSPPKTPAESDPSLGAEFAATEFAGEVDVSSLKKALTEVDLSAEAMDHLPDVRELDENLDTAFQLATNRGPLCAEPVVGMAYFLEAVELHAEDLDIATVRSRWSGVRGQLISAGQDAFRNGLLDWSPRLQLAMYSCDVQATGEVLGKVYGVVAKRKGRIVSEEMKEGTAFFTVSALLPVVESFGFADEIRTRTSGAASPQLVFHGYETLDQDPFWVPTTEEELEDLGEKADRENIAKKYMDSVRTRKGMAVDRKVVMFAEKQKTMKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGZ5</accession>
    <name>A0A2S5BGZ5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGZ5"/>
    <dbReference type="STRING" id="741276.A0A2S5BGZ5"/>
    <dbReference type="OrthoDB" id="3341596at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000034">
        <property type="entry name" value="Universal minicircle sequence binding protein (UMSBP), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="232" mass="23349" checksum="0D2DAA91EDB430BE" modified="2018-07-18" version="1">MSLPMPTPTPGPMRMNRKGCFVCGKPGHIAAACTSTERLCFNCSQPGHDSKACPNPKVVENKQCYSCGGMGHLVAECPSIRVSAMKAAGPKCYNCQQFGHIARTCPNPTVAPGSAAAVGLAPSIPTVAPVGAFPGMGGFAVPPGGYAGGGGGRGGFAGGAAAGGPRRCYGCGGVGHQARNCPTAALLAAPRGPRTCYNCQQEGHIARDCPTNIAPAAVDTTLAPLLEATRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHA8</accession>
    <name>A0A2S5BHA8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHA8"/>
    <dbReference type="STRING" id="741276.A0A2S5BHA8"/>
    <dbReference type="OrthoDB" id="2538211at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015547963" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="146"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="241" mass="24282" checksum="AB232E6A0A548872" modified="2018-07-18" version="1">MKFSLSACILAVTALSTVQAACHQRSRRQHGAALIPAGKQAVGPAAAAAVDTQVQTPKKVVRRHKSGRRLDVERRQGPPAPPSRPSVNLHDHNSKNATSTAYSASYTAAGTQTASAAATAESSSPSSSSGSSSGSSSGSSSGTYSGQATFFYQDGNAGACGATNADSAKIVALQTDMYGSGGYCGRTVTITNTANGKSVTATVADECPGCSSSESLDLSTGAFDAIADESTGEVPITWSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHD0</accession>
    <name>A0A2S5BHD0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHD0"/>
    <dbReference type="STRING" id="741276.A0A2S5BHD0"/>
    <dbReference type="OrthoDB" id="2535313at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="749" mass="81094" checksum="D8E87CAECD0B27BB" modified="2018-07-18" version="1">MADATAPQTTPEGDEYDEGEPLTATGKPYKRPTIVACIGCRGIKVKCRLPNGEAPTGFWGADQSKCTRCIRLQLDCVYKTAPRRGRRPKERQPSTGGQADAESSETSRAMALDQPDAFSGNAVASTSSALHAPHGQLAPHSGVATSSAGAGYPPAGLVPAVQVSLPIPGGTADAYTPGFFNALFPAVTRPSAAPSVLQPPTWPAPSRSTVAVPPAPMTSAGPSAAVPPAPHSTLSQSSPALSSGMHASPASQASASLDANPGLSLAEAAQARSSAFRSSQPEESQPAQIHRPGRLPDPVDLWILSEAEARALIDQWHEQLNCYVILLDRHLHTFAYVRTNSPVLFTAMLATAAKFFRHDLYPRLLAHAQNMVTRAMGGDIEPNIGVLQAVLLLVYWKEPLDASAWLRIGYAIRLGYQLRLYRKRIEPLPADELEARILLDRERTWIVLICFDNTYELHTDDGEVETRMITTYNVDIDAWLTETLPYDSVAQHAHEIILTTHRKYFEGSLLPGLTPLRGPASHKARFHVVATRLDLAQACLKASGVQDQLVLADAILRAGELVDCFDDAASSILLYVQDTIALHMLGFGEWIGRLFPHVSNAHQTTFVRYLTQVYIAATRAQRVHRAEAGGYIARFFRGALRAIRPESMPLTRPPSPRGGLGQTDSNPLRRVASPAQTGPCVVAIGEIYADLITGAIQEQEIFTDLDSLFADLKHDTTYWDSLNPTLANSTWAWLDEAFAAPQQGTVNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHK6</accession>
    <name>A0A2S5BHK6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHK6"/>
    <dbReference type="OrthoDB" id="2530161at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="528" mass="55977" checksum="601A928FC039974F" modified="2018-07-18" version="1">MPISPTMGAKTWRAPTIALADKPAAKKPDAAKQRKAEAAKEASKLARKRIVEAGRLIVEEQKDEYLARLKADVSKLEAKQVAAPTAGKKDDKGEAIKQADLVEKAKKMGEQVLARQRIEKRRQDLLARSVGQYSYGTSQLKGLPIPTGSLEEQLKHFKCTEAATLPGLLATFEPLDNARALQLPDLATLTEAELPAAYTIIGEAAQALQDELIRYAIQEYGANALVVFMVEGPIPIEEPELVLQGYIYELVASGVPAVVDSSSPKGSAPKLKPFAPPQPHHAILKPTFTKQPSMPQHVGFADSPLFGHLPYPMTPKLLPHPSEATAIPPKFSNNAALPPPSAYPYGSHYAPPFTPLHTPYAPQKPLQPLYSHPKPQPLFDGYQSGPPVPPVPPELANLPWGAQMYVKRIRAMQEEEERERARAAAAAAGGGGAAGTSAGAKGESPVGGIGAGPFSSNPVTAAPAAGSTFPAPPALANPFAPFPSVDPDHGGLDYNFATGPPWGPAGAGLGPSRVVPSQENGWKGTQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHQ3</accession>
    <name>A0A2S5BHQ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHQ3"/>
    <dbReference type="STRING" id="741276.A0A2S5BHQ3"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="216"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="777"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="838" mass="94001" checksum="11F7AED5034C8961" modified="2018-07-18" version="1">MDPRPDYVLAFKTDPNYNSPIRGLSSEKESTIRAKRADQVKSEWDRLVTTLKQANLSVTSRKGAAGTGTVLIFVKADEKRVREEATRERMSDWLHGLASPKASPREPRDFATEPIEEAERLRLVYSILTSPRTLGTPSIRASNATGNTCGLPLASQLPLPITSKPEFPHLVDMFPPHDQEFNRVWLQRWTRLPLERAQKNPLAVLEIPQHELDDLKAHLGEKVALYFAFLGFYARSLAFPSAFGAFFWLLGLRFHPLLGLGFIGWSVIFVETWRVRERAIAVQWGTYRLDRVEVERPGFKGDGFEVDPVTGVTKQRWSFGRTLTRGLASLPAYAFFVGCLGVIIAAIYAVETIVNEVYDGPFKRILSLLPTVLFVSVVPQVNGLWALTAGKLVEFENHPHRAEYEASYAIKTFALNFVSAYGNLLLTSFIYIPFGHMLLPHLLSRLPSKHASGLYAAATRQFSTNSQKLHTQLLAYTLTNQITGAFLEVGLPYLKNKFMPVIQEKLHQHEKQKSEENVEKFDDAPEEKPFLDRIRQEQMMPVEDIFGEYAEMVTQFGYIVLFAVVWPVSPLWSLINNVLELRSDAFKIATQMRRPIPHRAASVGPWLDALGFMTYVGTLTTSALIWLYQEREKAPGKSAQYLSHLMHKNVTLPASGGAAFWATRLSEAQSINAPPPSDAPLLMGALPPAEGGHDAFAAIKSLLVTAALVALASSQAYLAARGLARWLIARLEWDGSIAHQLSRRRDFELKRAWLDEHDMRLSPKEMCRRALGWAKKSAEEGMDEDEEKEKRQASDPSGNLERGYVGKPTDAAMSEPASAFWRGEDVGTRLFHAADKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHR7</accession>
    <name>A0A2S5BHR7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHR7"/>
    <dbReference type="STRING" id="741276.A0A2S5BHR7"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="198" mass="21058" checksum="5B36661FF4C94D4B" modified="2018-07-18" version="1">MATPSTSKWTLDYSPASSSKVKVQAPPGYVQPPTGKLAARSSSSSSVTKPTAASHVDLDELRQQKAWELATSPAKAVPMQAFMMYMSGTGIQIFSIMSVWFLLKQAVTGAMGVQQAFAGFDASVKPKSTSANDTPQSFLQQKAVYVVCQLGLLAVALWKIRSMGLLPDSAEDWAPIFGGWLMSTPASGIADPLPVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHS4</accession>
    <name>A0A2S5BHS4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHS4"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="171" mass="19010" checksum="E230C43DF04F7C3D" modified="2018-07-18" version="1">MQRRNQPAAVSYKEVDSDDEGPALSDDDNDEAPARVATAARPRGRRELKEDRPGDTYGAGESPSEKKTAKSPSVEDDVDEVNFEEALEAEAARTAPFTHDLLFRLPYLDMPDMVHFAKVSPDLNALLLSPASKLLWSRCRTRSGMPSPHAMSDIELATRLQGDECWCYQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHX1</accession>
    <name>A0A2S5BHX1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHX1"/>
    <dbReference type="STRING" id="741276.A0A2S5BHX1"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="414" mass="45109" checksum="AEB403612AC40CCF" modified="2018-07-18" version="1">MDKRQLTNFPPTQTRFWAVRDYLAPVLRDSKFKETGRITPDEFVAAGDFLVYKFPTWQWEAGEPSKRRDFLPADKQYLVSRNVPCLRRVSQLGQQTGAGGLNAGDEYAEMLMDLAAEAGEAGGEGDEWVATHTNVQDIHSSHAMPSIADIPDADDPAGSSRRSDVNDLSSHLADTSLNPDDIPDVDDIPDMDDEDEAGGGGGFVEEEEDDAAVKVEPVSNSRGAGASRSDNLVQVRTYDCMITYDKYYQTPRMWLLGYDEQKRPLPPTSALDDVSADHAQKTVTIEPFPHSSSLSIASVHPCKHSSVMKKVIERMDGNVREMQRRERAGAGSAGTTSVAAGDKKASSSGGSKWLGLGRRKESSNAASGTSGAESSQPQQQEDEEGLRVEQYLLVFLKFISTITPTIEVDATASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI95</accession>
    <name>A0A2S5BI95_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0701</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI95"/>
    <dbReference type="STRING" id="741276.A0A2S5BI95"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="67"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="355" mass="39280" checksum="55D366E285CD3974" modified="2018-07-18" version="1">MAGKKRPAATRSPSPDSAERPARFHFPSVRRGQPLVDTYTYHSVDPVDSHDQGKQREDAITAEVAGEWMLGVDEAGRGPALGPQVYGVAFCRLDYSDRLKEMGFADSKTLTDPLREELFKQMLEHGDDVKYAATIMSPNDISMGMLRKVPYNLNAQSHDCTINLIREVVERGYRLKECYVDTVGPAADYQAKLSSFFPTIQFTVTSKADALFPIVSAASIVAKVTRDRILEEWMFAEPGIGEVNEREDEEKEEGSDEEEEAAADAARLFGSGYPSDPKTVMWLQSNFDPVFGFPNVARFSWAPVKNALLKKGVPSKWNDEPASIQKYFSADAHGKGAAAQAPLWKDLALVSVGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIC4</accession>
    <name>A0A2S5BIC4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIC4"/>
    <dbReference type="STRING" id="741276.A0A2S5BIC4"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="610" mass="66302" checksum="24C6868B0C536130" modified="2018-07-18" version="1">MAATTAQRTVPGAAPSGPLTKAQRKAAAAQSASASSSSSVNSAALNGTKGQDPTAVVIDKKDEGHSNSGRPDKAKYDQEQDSLRAEIDTLQAKLNDLKNKISASSNRGGPDHERKVAIRKELDSLRGEQARIKGGRGKTLDQLKNMQEAMNKKVKDLNAAKAKVPYKTTQDVDNQIKSLERQVESGSMKLVDEKKALAEISTLRKHRKTVDSFASQQAAIDADKQKIDEVRKELDDPEQKAASQKFDELRKELDQVNKRMEDVSKSRDALFDERNALSKQLDELWQQKKASSSAFRDANNAYCASATLLFVPVALSNRLADALLVSTDQKLNEDRAKRDERRKAERKEFEDSKRAEVNERLLEEAQAPAFERDIEDCQTLIRFFQQRIGLPPSSFNGNGTGAGGASSGLGLGRNKVAGVPELEPRKVEQADFPKGAVALKKKSEQEEESWGGLASKSKKGRKAGRTNAAAAEGDEAASDDKLNLPFGTLSGLMALGIPAPLTTGEVQKTIDSLQLKKKYFTDNQDRVTKERVSAVQAKIAAAEKNGKPISEIDAVAATEPSAKEEEIKDAQPQPIEEGATKEEAVKNAEATADAPEEAEELEEGEISENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIG6</accession>
    <name>A0A2S5BIG6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIG6"/>
    <dbReference type="STRING" id="741276.A0A2S5BIG6"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="141" mass="15433" checksum="22314E4995DE1491" modified="2018-07-18" version="1">MSTNAHGSQTAFALWIINKAGGLIYSRTYADGLATLTSNDNLILASTFHSIHAIASRISPVPRSSGIHSIEADSFKMSCLQTPTGIKFVLSTTPAHPSPDAVLKRVYETYADYLKDPFYTIEMPIRSEVFEQKMAVAVRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIP6</accession>
    <name>A0A2S5BIP6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIP6"/>
    <dbReference type="STRING" id="741276.A0A2S5BIP6"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="757"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="678"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="885" mass="98452" checksum="60F1181C9655F4FD" modified="2018-07-18" version="1">MAPPTPGRHRGPRPQVNNNIGEAGRQVQTPRHAYIPTRRLTLFGFPDSRARLSRRTTNIAPPKGVPRDSAGHEQVEAFFDSRKYDRDHGGASDDDAGQDDVDDYAAAADQSTHRSAPRRKAEQAHRRTQYSDRDDVGDDDDEEDFGDQVRRSNQARKPQQQASARKRQSVAQPGRTPTGARERGAERPDRYMVGDDRGRKTGITKPVVQRDEDGMEDLDAYFASPEGGRSIATTTAGARSTIKKASRNNYAAFERDEEQTGAYHEQEGNDQDDDGTLLVARGRHPGADSSDDSVLGISPLTYQRQHPSTGRAPSALRHSTTAAGERSVSRKGLSSPQANGVGSSASKSRGNRRRLSSVENDAEQQEYDDDEPYDQQQAYNEEDEDDEEEEEEVRAALGAKPTSTDASPAKKPRKSVASNRRASDDDYQRDASLELADSPSGLMKLDRNGRPVPADRPKNKGKGRASDYADSPARRETFVREEVKEQYVEQDQYYPDEFGGEGYGEDPYDQRAYGDGGAGGEDDYDSADGQAGHDDVDVREVDDAGNVISEEEDDDEDQQMQGPSSKPYKGKGKGKARARPSSNRRSSDSQSVSPQRRATSSKQARRRPQNQSQQQIVTEVSRKRTREAGTVDIDGVRRSNREKVPRLEYWRNERIIYERRRSGVGLKAIVRVPKEDPVPLTKAGHRKGHHGVKRSTSARAPSRGKSVKAEVPEEQGCDDMTDPDGLVWSWEGEAETTRRIAFTEKMMDPKLTMDGKFAYQKIYQELDYLASGILTIPPGGEKGLKSSKDNSYVFCVLQGSVSVTVHRTRFSIGPGGTFFIPRGNMYCIVATSNREVRLFFAQGRRVIEYADGETRPDTREDSMRFIENEELQAVPEEDEEDEDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ05</accession>
    <name>A0A2S5BJ05_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acetolactate synthase</fullName>
            <ecNumber evidence="11">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_0335</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="11">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ05"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ05"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="107"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="314"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="526"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY76743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="711" mass="76778" checksum="24B4B2E1A1C8D060" modified="2018-07-18" version="1">MHRTLARSSRALRSSPIASTSAATLPSQSTSASGSRFALQQAQRRLAAQSRGLATATDKVEAQVQTRAKPAPNFQQVPPSQSGANPLANPKLKNVDELDSSFIGLSGGQIFHEMMLRHNVEKVFGYPGGAILPVFDAIHNSPHFDFVLPRHEQGAGHMAEGYARVSGKPGVVLVTSGPGATNVITPMQDALSDGTPLVVFCGQVATSAIGSDAFQEADVVGISRSCTKWNVMVKDIAELPRRINEAFKIATSGRPGPVLVDLPKDVTAGILRQAIPWRYTHPDLAESNLPSRQRIHTATSQAGGEATPISDALINKAAHLIANAKRPIIYAGQGMLSTPEGPELLKRLAKEGNIPVTTTLMGLGAYDELDETHSLHMLGMHGSAYANLAMQSADVIIALGARFDDRVTGRLDMFAPAARAAAAAGKGGIIHFEVQPKNINKVVNANVAVTGDVIESVRALLPLLPKQADAREEWFAKIKQWKHDYPFTYVPSDPSKGELMKPQEVVESLNDWCEAYGKDKVIVSTGVGQHQMWACQHYRWRHPRTWVSSGGLGTMGYGLPSCIGAKVASPEKVVVDIDGDASFSMTAMELATAAQYGIGVKVLVLNNEFQGMVLQWQDLFYEKRYSHTEMTNPDFVALAKAMNVHAIRCDSLTDLPAKMKEFMEYDNSKPVLLEARVVKTEHVYPMVAAGKALHQMTVHPSLAPLGDKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZJ6</accession>
    <name>A0A2S5AZJ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_7046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000161">
        <property type="protein sequence ID" value="POY69954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZJ6"/>
    <dbReference type="STRING" id="741276.A0A2S5AZJ6"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000018">
        <property type="entry name" value="Receptor for activated C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="143"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY69954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="311" mass="34260" checksum="C998CDDD2D3C7453" modified="2018-07-18" version="1">MSLQGPTPWLVGHKGDVTAIATSAENPDMILTASRDKTLIMWSLTRDESSFGYPKRILHGHNGFVSDVVISSDGQFALSSSWDKTLRLWDLNTGLTTRRFVGHTGDVLSVSFSADNRQIVSGSRDRTIKLWNTLGECKFNITEDGHSEWVSCVRFSPNPMNPVIVSAGWDKIVKVWELSKCKLRTNHFGHTGYISTVTVSPDGSLCASGGKDGITMLWDLNEGKHLYSLEAGDEIKALVFSPNRYWLCAATGSGCKVFDLETKTIVDEIRPELEASKDGNLPQATSVAWSPAGDYLYLGYTDNVVRVYTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZL1</accession>
    <name>A0A2S5AZL1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_7022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZL1"/>
    <dbReference type="STRING" id="741276.A0A2S5AZL1"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="628"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY69978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="677" mass="73090" checksum="66B32B67335B9AB4" modified="2018-07-18" version="1">MLAEFGVAAESPFVALTSAALAPPHRPHSLQSGLYSPLLRSHSWIKRYTILQELGDPEVAAASSGRGGIPRGHAVISEAYGSTGCVNASAWEDAGVGARLATAGDDTKICIWSPGVEASLYEHGGDAQSPSLAYGLTETIDTGHRANIFDVAWAPKTPNSLFSVAGDQTVRVYDLSLASNSKLSSTNITPPPPHRPFTHYEDASACTQVYRCHSDRVKRIATEASLYVFLTCGEDGAVRQHDTRQHHQCRTSRFQDPADAGCPPPLASYPSLSLYSLSLSLLRPHLFVVAGTSSYAFLHDRRMLRKAAADWQISPSAAASNDLTTCVRRFGVPNPVEPWKGELTKHIVSAKLSPERPSDLLISYSDDAMYLFDTDSETYTRPPKPRQPQEDEMWLGGETMADERDDDPESEHGEDATDVMQDLVEKEDSDDSEEEGGPATMELGAGPADTLDLEEDENGVSDDDEEDDDDNDSEFGFDPYVPDAIAPASDVPMIAPKQKYEGHANSQTVKDCNWLSGDLVVSGSDDGNWFAYDRNSGEVRGIFKGDSSVVNVLNPHPRLPIAAISGIDEVVKLFGPTADFELASQSNLAGEYETIKQRNARGEGRAHFGQGIGAERLLQLLFARAGALGGGPDGDQDDDETAEEGGGEPGAARPRRRFRIVTSGEDGDEVAQDCLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZS4</accession>
    <name>A0A2S5AZS4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RDRP core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000153">
        <property type="protein sequence ID" value="POY70038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5AZS4"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="563"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1314"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1422"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1485"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1595"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1796"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1520"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1426"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1493"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1595"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1642"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1681"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1825"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1843"/>
            <end position="1864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1864" mass="204766" checksum="AE562DD9D305EA57" modified="2018-07-18" version="1">MTHASKHLKPAGASDWIDSLHRAREEQDRDERRRRRQKAGQAPELPRVPVSYAQTPPPAQLRPAAVANARGRPKDWTAAAPSPAWTAEPTRRRDSGDATYGTVLERDPDPARARRGKFSIQFTRKEESAPLLRPTDLGQARVAVSPVPSTQRYPQRPDWSAGEAVRPAQMAGVGPALSPPAAPLPFNGEAPAPDTDADVLEPFLPQDLRMPPVLLDPKWPGFRISALCLGSFDERGLGYFAVERDVHIQQGLLEFIGATEKGRKGTVGVGGYAFDGAPGIKLSFTPGSISSLYWSPAPSSPDDDPGLERIYLIIGTRWTPRFYAYISHQPDRHVTSQVRVSALDARHARQVPYLSRHFLVVVDLVKDPARSNGSPVPPASLADFLQHCTINDLPEPKRLDRLELHKEKRYSRDIMHRLEETFSTLSPTHAYQLEGILRDGTLTPHEVGWLIEEHVKVWSVTVEIDRDSTVEEILVELRNQLVEDRKARAALFALGIQAPEQLQAMPFEVSHMADLAREAVLHRARVKLDEPVRLGGSAAEKVDSRTHFWCRGIVLTPSGTLKVTGRMLEKSNATIRRYYHDVDTHRESDHFLRVAFRDEGDQNLQVVSAGEVGITQKRLLDASVTKALKRGVKFAGRTYEFLAYSQSGLRDRSVWFVAPWEDVDRHGEPYTMTAERIRQQLGLFDKVNRQPAKLGARFSQGFTSSIATVLLHHTKIGSRPDIVERDDEGEESTNHTDGAGVMSTQLRDEVWQALLANGFRRDQDGPPPSVYQIRLGGSKGVIAVDDTLEGSQVQLRPSQDKFRGFAERIGVSNNFCLNVSDAFTRPNPLRLNRPLVSALEDLGIEKEIFLAYQKLAIDDLSPEALFTLSGAYDAVNKFSYGGASRFKSLLKSLRNLPGFDDRILREEPFLRAALDVIRVRCLRDLKDRARIPLPDSYVLVGVPDEDRLLKPNQVYACLRFPERPDAPIYLKGRVLVTRSPAMDPGDLRVLEAVGRLPSKLVTRMRSLENCLVLPTRGERSVASMMGGGDLDGDTYQVITLPELVPADTAPPRPHEAQVPLELDRPAQIEDVSDCFVNYLCNDTVGQIAHLHLCLADRSPSHGFDPRCQQLADLYSLAVDAPKTGNVVPADALPRIKRTARPDFMRKSDTAEISVTPDIEYYKSERALGYLYRSVDDSGVATPTCILETAGEDGKSNSIERVHITIKHDLAAIFDASPERLQGIVQRHEAYLRPVLAAFTAALSDAAVTHTPPRQDDRKLSEVEIFAVATLHEVQRGEAARGNALAAMAQQVSALVEWLASCLEGETNAEEHAHVETLGLRGEPTARGRSARSPRIPSLSTGSRILHPAGPPPVIPASQPTLFPARPSTSSARSKEPSSASPRGDSLQSSDSYKRANAFASFKRPPLSSSTLPTSDELDHPVKAAVSSRNSGQQPAISRMQAATSPRPPYPTIRISPSQSSESETDDSTSAAAYIASLLLPQGEARPTRIITKAGPPSATTAAQPSASAKSDDSSDSLVAEAEHRHAYEELKRQAAELQRLRDEEEARERVYAEFRRRQHLKGINIPSRIREPNAYQTHRADFLASLRPQDTSVCLVSSAPSSSSRSRTPELERPYTAAWRAPAPGHDSGAAPEWPRAPPTGHSPQTPSHVPSSRTPSPTRGGASQSDWPAVSGASKAGWASETTSLPTGSSQIDDASSGAWRTSVPAQQQWLTAPRAGALEGPGARPPSGVSHEWRSRSPSPPTPPTARREYFRNEPPPFWALFDDVDKGRYKSNQTGLGKLGRYMVTSDGQTYRDAYGLGKPTGPKRGGGRAYRSKGDGRRWQAETSWLQDTQRQVNDELSGWGQRAAAAGDASRAGGSAWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZZ8</accession>
    <name>A0A2S5AZZ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair protein REV1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_6873</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZZ8"/>
    <dbReference type="STRING" id="741276.A0A2S5AZZ8"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
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    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
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    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="100"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="15">
        <location>
            <begin position="436"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="225"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="297"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="848"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="981"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1076"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="866"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY70099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1205" mass="131628" checksum="F44ECFB16803E969" modified="2018-07-18" version="1">MMSGQLQKRPRAAQDGPGPSAMAPPPAKRRAEVGTSGTDQSSPPTNDASSVKDGAIDEGEDYRDQDFYEPVKFGEFGKYMRNKRRKLKVQNAALLEDGNARPQIFKNLRVYVNGFTESITLPELTELLVRHGGEYVPYLDKKGLVTHIIATNLTPSKRKEFAKYKVATPNWLVESAEQGRLLDWREYSLLGAKAQYESGATFGEGTLASEEAARLGTQTGQRSLFSMGVGRHGKPPAGSLAVSNGDDRPTASTSGRPPHPTVSTSKNVETRESLAERGARLAREALRAQAAGPLHSFFAQSPGAPNTGTIPASTSKSVSVELPAAPTRPITPAKSTSTLPATTDSPTKPNALTRSWLPSKERNERTAALLKDEDWLAKHTSASPDFLAGYFAQSRLHWISSFKEELKDLIATKQQGKDLPKRRGKLTGGAVDGRTIIHVDFDCFFVSAGLTSRPELRGKPVAVCHARGKGEAASSTSEIASCSYEARAAGVRNGMSLGRARDFCPEIQTMPFEFELYRSITLKFYEILLSHAAYIQVVSMDECLAEVDVPPTIFRDQDPALDLARRIRREVYDATGCQASIGISHNILLARLAMRKAKPANIFHLFPEDVDEFLLPLDVDALPGIGWSLREKLQRELGIKTIRDLRQAAPAKLADAIGRGNSKKFTSFAFGVDDAELESQKLRQSVSTEVNYGIRFGPGRVDQVERFVRELGDETAKRLRTAGLKARQIVLHVMIRHPDAPVDTPKFLGHGHVNQENRTSALSGSGGGGGATDDGGVVGEVAWRLMSSIGAPAHELRGFGIQLTKLERDGVSVETVHEKGQSRLSFKPRAVLAAAVANEAAQAAVVSSSTNAEIATAGSRVTSGPAKDRPTRRDVIPPAAKAGQPDTLVLDSDSSEAESRPDHKHTRGMDMAATRLRPRSRQSSRSVEPYIPTMFKPTKKSARAAPKSASQAAPEELLYYGIDPETFMSFDRALQAEILADARRSKPPPGKAKTKNARKTAAVAPTKQQSAPPEIIVLPASPAEVTDSQIRAMQYDPEIFRELGKATQAEQVELHRARQARTVTGDRTARLHRNDPTAYRRNRPPVKDVTVRPPPRFQGQTELSGILDRLELWMGTATDRAPDRGDVDALGRYIEKCAAREHGHNLAQATEVMQWWRYLIDSTFPPAADRPDDGGIEGLWRSGYQSVVERLDRVVEKATGQRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B077</accession>
    <name>A0A2S5B077_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B077"/>
    <dbReference type="STRING" id="741276.A0A2S5B077"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15558">
        <property type="entry name" value="PHD_Hop1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HORMA" evidence="10">
        <location>
            <begin position="31"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="770"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="828"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="896" mass="98403" checksum="8910BF418B838F3C" modified="2018-07-18" version="1">MCRRCSSRAAEMAQRMRPTEQKVEERVVTVQSSLQQVKELVETGIGCIAYLRGLLPEDAFADNKLAALRTTSLRSKSAAEVGAQSKVQPGPDDYTYVRVKKIKRGATTEGDKLLDYLELGAAEAIEKGYLHKLVFAIYLDPDEPTNIVESYTFTFTYETDSEGNKHPDMFVADQFSSMALSAATFDLQPRNKPRKIGDIKRQIQQMIKNLITNTQILEELPKRRFLNFRLFYTDDTPAEYEPPCFFPVPLDAPGYSLTTPSVSDVPEFCTLGSLVTGYHGVALHTVSITDHLDVKYDETISPEEALARNKRDAETRPVVWDGEALAQAVTDEDAKVVEAVPLGVHDVSGRFLPLQEVVNGDTEEMERERKRAGIEPNPEAVFVPQGRLEETIVDSHMSDNEALRRAIAATEKRPASNSMPATQVEPVVSRVRSYQPPVPFFDETQAQYQERLRANSNANAEAGPSRIRAEEKIVAGERAAGPEAEEAQPETQLIDYSQLSLQADQVAQEPLIETGPEPIAGPSTDSRSKQHPRDSKAVSEKHPKHDKHDKPPLPSRRSSRNRATFTADACECGDKEDDGGMICCSTCEVWKHAVCYGYEDAKDSRIPDIFVCYHCRAQQGLSDLSIERDREAEIGQALAELRSLALFRRAIDAVWHNGVLSIKDLAKYLAVDNSTAGQVLKRLKSESFIVEQSASRKSKGKGGTQVGSLKAPAQAVNKTSKQVKRKKLDYFSPGGGAEAKLISLLEPNNKRTQEEDVEMTDVLSVPAKPAMGAAGTAAPPMKSDNASHRQSTVPDSIVDEDTSQESAVASPAVIRNADADKFIADATKKGEQGGIVVIQPDDDADEGVAALEGPDAPKRRASMAELDANVPRSSQDSGQLPRRKRQKCSEANEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0A7</accession>
    <name>A0A2S5B0A7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0A7"/>
    <dbReference type="STRING" id="741276.A0A2S5B0A7"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015511470" description="SGNH hydrolase-type esterase domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="3">
        <location>
            <begin position="66"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="300" mass="33346" checksum="E22AC49DDE0AAF0F" modified="2018-07-18" version="1">MLGSTTLFLAGSAAVLLIARYATHRELPRPPLTADSEKGFASLVGPDQTLPAMSQPHSVLMDQFIVFGDSITQGSWIPRGTGAALSHVYQRKLDVMNRGFSGYNTEMGLQVLKQFLPRRDERLPKIALFAVWYGANDAAVPPSPQAITLEQFKANLNKILDMLRRPDSAYYSPETQLLLITPPPVDSSVRNRDLAERDPPRQPDRDSERTRQFAEAVKEVAVASKLPVLDAWSLIDAAAARDGGLGKYLNDGLHLTPAGYQVVTDGLFKLIETELPRLHWSNLEQVFPHWTEFIPESMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0F9</accession>
    <name>A0A2S5B0F9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0F9"/>
    <dbReference type="OrthoDB" id="17066at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="311" mass="33937" checksum="94D73DB62B92210F" modified="2018-07-18" version="1">MARGKGTPRRNRELAETGDDDDFSPVSRSPSNAINSPRRTTSTSATSSPSKLALNRDHTANVAAPVKPARGPLPASAETTYHQRLRQILVDHRKARRAWNELVIRGLIGRTRAVLELWVDVELALKAIEKQKTTTSSNVRAGYLFAQAAKLSEQIAAVEGVFANLSDIVDNMHSVCERVEYLVIEAAKTRGTVFAFREPMWVTWPLARFADGIQSLSTPYIQSLALVRSLLDTLLTFPPLPSSSADALSTDAPVNSAKATPAETNKRPSNEEIQAAMSLLAVQPLLPGKASDWGNEGWEEVMAVEVGGWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0K5</accession>
    <name>A0A2S5B0K5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_6602</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0K5"/>
    <dbReference type="STRING" id="741276.A0A2S5B0K5"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="178"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="297"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY70322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="339" mass="36312" checksum="6D3A4B2BBE3F6B0A" modified="2018-07-18" version="1">MATAATILSLRKKLVAATGAESPKPAEAVEILKQLKTQVVATDELLRETKIGVTVNKLRNNDAKEVADLAKELVRKWKADVGQSGSKKTTTAAASTATSSAPSPASAATPKSPTPKAEPTPSTTVASKPAPATASSSTSSSSAPAAPLRRQSSGGPPRTHKADGIDFAKGDEATGDKTRDKCCELIYDALAQDSGAPSDLILTRSRALEAHVWKQNPPPSGTAAYRNKMRSFYLNLKAANNPGLREDVVSGEISITQLYEMDPKDMASEERKAENRKLAAENLFKAQAAAPQQAETDAFQCGKCKQRRCMYYQMQTRSADEPMTTFVTCLSCNNRWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0N9</accession>
    <name>A0A2S5B0N9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0N9"/>
    <dbReference type="STRING" id="741276.A0A2S5B0N9"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="9">
        <location>
            <begin position="225"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="306" mass="33519" checksum="A38CAC3AB358679F" modified="2018-07-18" version="1">MTADKDAQLWDTRSLVQAKAGDAAPRNAMVVLNSPLPPQSLFRKLWQNGTASSWSREGPDLRFCADGGANRLYDRFVKGKDRADEANWDAAVDGDEDQWLPDLILGDLDSLREDTRKYYEGKGVVVERDPDEFSTDLGKNVSRLAAIEAGTASLPRHASESPADSRPSQRGSSEQYQLVIIGGLSGRLDQTIHTLHALTLLAEKEGRDRIWTIGKESAALLLTKGSHRLRIDVSLFGKTCGVLPVGCSEAYVTTSGLEWDLGPTAYMYPTSLSTAVSTSNHLVQEDVRIETDKPVVWTMEVRGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0S0</accession>
    <name>A0A2S5B0S0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0S0"/>
    <dbReference type="STRING" id="741276.A0A2S5B0S0"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="302" mass="33353" checksum="3F0F335BD24E7762" modified="2018-07-18" version="1">MKMPTKMRAAVGQMCSTDNVKRNAEMSASIIRRAAAADCQLVLLPEAADFIADASKLQELAKPLDSNDFVKRVREQAKESQVWVSVSIHEGTGTERCKNATLLISPEGEVVQNYHKLHLLDVNYGNDGPILESKTTIKGEKLLEPYQTPVGKLGMLCCYDLRFPEGALSLRRQGAELIAYPSAFTMQTGKIAITLPAALGYVFGAKVLLRARAIETQSYVLAPAQIGQHSKERETYGHAMIVDPWGGVVAQASTRPPSYPPNEDDVDCGTFVSAEIDLDWVKQIREEMPLWEQRRSDVYALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0S2</accession>
    <name>A0A2S5B0S2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Phosphoribosylaminoimidazolecarboxamide formyltransferase, or putative IMP cyclohydrolase</fullName>
            <ecNumber evidence="11">2.1.2.3</ecNumber>
            <ecNumber evidence="11">3.5.4.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="11"/>
    <dbReference type="EC" id="3.5.4.10" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0S2"/>
    <dbReference type="STRING" id="741276.A0A2S5B0S2"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="619" mass="67255" checksum="4B7B3644782357C2" modified="2018-07-18" version="1">MAFEQQPIALLSVYDKAGLLPLAKGLADNGVRLLGSGGTAKAIRNAGMNIEDVSDITKAPEMLGGRVKTLHPAVHGGILARNIPSDASDLEAQKIAPINVVVCNLYPFNETIARIPPPSIPEAVEEVDIGGVTLLRAAAKNHDRVVILSDPTDYDEFLAQWKAGKGTVSDEFRQRMAVKAFSHTAAYDTSISNYFRRQYVTADAIANAPADQKAALTERAQQLTLRYGANPHQKPAQAYVTEGTLPFTVLSGSPGYINLLDALNSYALVHELSRAFTPNKAAAASFKHVSPAGAAVETKLSPEEVKVFDVDGVGELSAVASAYARARGADRMSSFGDFIALSHTCDVPTAKIISREVSDGIIAPGYEPEALDILRKKKGGKYCVLQMDPSFVPAIMESRHVYGITLEQRRNDAKIDASTFGNIVSKNKKLSPEALTDLIVATIALKYTQSNSVCYAYNGGTIGLGAGQQSRIHCTRLAGSKADAWWLRHHPRVLSFKWRKGIKRADRANGTDVFVTGEIFDAEEQGSERKEWEALFEEGQVPAPLSADEKRQWFDEIKGKVSLSSDAFFPFPDNVWRARRSGVGHFAAPSGSVMDDKVIETANEDDSVYVFTDLRLFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B123</accession>
    <name>A0A2S5B123_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B123"/>
    <dbReference type="STRING" id="741276.A0A2S5B123"/>
    <dbReference type="OrthoDB" id="2526477at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="405" mass="43614" checksum="DA4A8536E15C374E" modified="2018-07-18" version="1">MPSGNRTIDDQDIAIQYSGPWHFYRGSSPTSDPSRWNASDWFSGTFASCGGTDPTAPRATVPCEVRFPFRGTYAAMFGDSNGSHGVYSCRLESDEADMPTEAEGLWSWFDGGSLWWWKYRHNVTLCAVAGIPDASHTLVLSVQPSEVYQGIAFDFAQSSDLVPAGETFTWSSDFTTAVPPTEFRNTTATPILPTSTVAFGAAPSATNGAGSYSDGGASKLGIALGIGLGLGLPFLLGAGLAMWWYLRRKRRRASIDYSGTFEVQSVRNSKSPRALARDGDFGTDTLVDSGMEKEGTGWYGRAGHEGAYGSHATIPASPVHYSPASYDFALPPSPDATMPMLEQRASYPGSPSLYPPASSPQRHRWSAPTFQGDSDDLAPVPSREISGLDLPPDAELDDPNTFRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B168</accession>
    <name>A0A2S5B168_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B168"/>
    <dbReference type="STRING" id="741276.A0A2S5B168"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="776" mass="85154" checksum="2A47AF55C865A0B0" modified="2018-07-18" version="1">MSGLLDLIRQRYIDTLRAVPSRWKVLIVDQYTQAMLHSVLSTYDVLEEGIQQVDLITNYRQPQPRLAAVYLLMPTSLNVDLILRDYAPSRQQEPTGKSSKKQAAQAGPQDPPKYAAAYVSFMEGINDALVGRLTDGLPESYLQGLKELYINCHALEPRLFTTRSPHSFFTLFAPPDGSVEHAVARWEDDIGWTARSIVNALATLGEYPLIRYYNPPSSFHPPLGPGLAVGEPVGKRLAERVQAEIDAYARDNSNFPSQIVTAVNYPVTDPPRPRGVLLITDRSMDLNAPFLHEFTYQAMCHDLLRIEEGQRYRHTFINEQGAEEEQEAILSDQDKVWVEVRHMHMKDALDKLIADFKAYAGEHGGTFGGAGASINDMKDMLASLPQMREVKEKLSLHLTMAEKCMSLFDKKKLPATANVEQCCATGVTPEGKSPKTLVEEMVPLLDDRSVSAVDKVRIIALYIMHRDGVPEGDKKRLYQHARLALHEMDAIDNLTHLGLNVNKDSGKKRKPLFKQREEEDAYDISRYQPALRFMLESQFAGTLDPSTFPYVRDAPVGATKSSAAASAAPPTTGSLRSARPQWTAQRTKRVVDAPRQRVLVFMAGGATYSEVRAVYKVSEAANKDVFLGTSHLVTPQKFVSDLANLVRGGGGSSHTKQGFQPLLKGGKALPPRAPGMPQQAIDQRYPQQVQPPPAPAPTLQQKAAASASDARRPSSLVASLKGSTNSKGSSSTLAPGATLQHSTSGSSLGGQSMQSATSDGASSGKIKKKGFLKRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B197</accession>
    <name>A0A2S5B197_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B197"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="970"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="657"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="807"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="868"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1240"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="717"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1254"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1394"/>
            <end position="1413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1570" mass="164334" checksum="A9DEDF74A72DD6D5" modified="2018-07-18" version="1">MSNPSAPGAKAPASPFNYAAAAKKSKPAPATVSGQDATGYVNGSQSPTIPNAAAVAAAAAASPAGGNGSQPTSPVQNKPSVQVDGVRVPPARVDEVRGAVKADVSFGTAGDKNAKLSSSPAAPPALDNGAPKAFGSVPASAAPAAAPAAAPEKKMDLHAFFRSGGGPAGGAPASGSSPSPVSVPSEQRRSLSTYDPQSQSRSPQPSSSPLAHPSGLPHLGNPGAATFVPRQQNIPPPFIPQQSQHQAFSPPNAGFQMPPQGVAYGQQPAFIPGKGPSPSPQNIPNGGAHSQASFAPSSAGSRAGSYVGSPQMGGMAPRPPVQPNRQSFGGPTSPRMPSVGLPGGQPMMYPNYVPQGYPGYAYGYPAAYGQFMPQQGGPAPPSLTNSGTTTPSTGVHTPKPAPSTVPTSPSLAPNTPATPSFHSFSPQPQHASLPGSAPRHPNPAAPQFTPGGSAAAPSTPLRSLAGVPEFKPNFEAPAFSPTPRRSAAIKIVNPKEKLEREAKEKAEREAKEKAERRARGEPEPEPTPEPTADAEETEAAEAAEQQEKKDVADREAKEQGEKEEQARLDAEAAEKKRKVDEEERAKLAKEKEEAKAKADKEAAAAKPAAVEEVKREETETPDTSAPSTPRTEVEGLEVKKSQADAVRSEEAALLAQEKISTESKDPAQALAEARETLNAVEPVPSPTGPSAPSTSSTPAFLPATPVGEPPVTDETNAAAEASTSSAPAAAVPSDAQLEAARSITNLDDVSYPDSAKGPEAGLNAGAEPGKYRYDRDFLLQFMAVCTAKPDSLPNLADIGMVGDDGIPARGGSFGGRNRGQMGPPSAPSRSGSSVGSFRSSSVGGPGGGFAMGNFGTGANVGMTSEQRFQASLSRAPSGAFGGGRGSMSRTTSQSGMGGAFSSGGRNKSERGSKRRGGPPGERDESRKPGGHVTGDGFEGATLEPRSETGWAPTVIAGATVADPNSIEMVQRKVKALLNKLTLEKFDSISKQILEWANKSIQETDGRILRQVIALIFEKATDEATWSEMYARLCRFLMESVSSEIHDESVKAADGTPVTGGALFRKYLLNRCQEDYEQGWKNKEAAAAAAKSKEADDKAKKDANDAAKQEAEDTGKEPSKEAELLSDEYYAAQKAKRRGLGLVRFIGELYRLTMLTERIMHECIKKLLANTENPEEEDIESLCRLLTTVGKGLDNAKAKQHMDVYFSRMRTIADNPKVTSRMRFMIMDVVDLRASRWQSKQEAAGPKTISQIHADAQKQAEESARRVASSGGKLPRLGDQLSRPNSRRGQGRGEFGVPQPGADGWTTQPQRPATAGNLSGFGRFRNSGADSPGGISLGPTGAFAAKSKQKKEERPATPSNPFAALMGGDSEEPSAAPAEARPKLQLKPRTKPLEGEGEGEGEEHKEDEEEDDGAIDPNASSMSRSEAERRAKNSVEEFYAVKNVAEGVASVEALPKEYRPLLITAIAEAALTKKADAVNIAKDMFTQVASKEIVAHDALIGAFEPLFKTLVDTAIDAPGAYGFACQLLMGISATADEIASLKGKMESEEGEEEVEYGRENFDKAWEKANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1A2</accession>
    <name>A0A2S5B1A2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1A2"/>
    <dbReference type="STRING" id="741276.A0A2S5B1A2"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="302" mass="32073" checksum="41A175EA59A9A314" modified="2018-07-18" version="1">MLYSPALASRTLAKYTVPAAAPFAFAARSAVLGFHHSDSSRRRHHFRPQQVASRSHSTRATMTASTQLLQGILDANETYAAAFAQSDPALLKKLAQGQAPKIFWLGCSDSRVSAELATGVAPGSIFVHRNIAQCFHPGDPSASAALAYAVHVLKVEAIIVCGHTGCGGVKAGMQAAVDSKSKEDQGEKEEAPKPGSVEETIAKWIAPIKHLATPHANNASDPLSTLELGSLTDEHVKETVKAVAESDLVRAAWDEGRELSVHGWVYHVATAKLRDLDCGYKGPGVKADSLSRPSTYADSDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1H9</accession>
    <name>A0A2S5B1H9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1H9"/>
    <dbReference type="STRING" id="741276.A0A2S5B1H9"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="2"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="514" mass="56464" checksum="6EAADC339F1FC46B" modified="2018-07-18" version="1">MKRLILLCDGTLEDASNEKNPALYSNVAKLARALEDLDERAQIKLYQGGVGTEEPVASSIVAAGLGRGMRQKVRALYDFLAMNWQAGDEIYLFGFSRGAYTDVIGILPPQSYLELFPVLFEALDAHTGKGDDDDKEAQTRLAKLLQPIEPFRKQQALTLRGRRLVECLGVFDMVGTRGRPAALRVSSPYATRYDTFGFEESRLPSCVARTYHALALDEHRIDFLPVVFSIMAPSTPDSTGLPQKLLQVWFSGAHADIGGGYAEGDLAAIALYWMISSVRDKLALNDSYLGRASRPLHAPWGQFAPHNSAVPPFNLAKRVDRTLPDLANPTSQQFFHRSILSQPDAHLRPDLIAFLQDAHFDDAFFVELSPYEQQQGRCWLVANRGEADSKPQSPTPTRPNDKTTFGSAAPSESIKSRPRVSPARPSSTLSLTDNEAPERGQRGPDAVAAPPTAPEPASVSVANLQDSPFYPLPRTTDALDARSPGATHRGFFAGVRRRFGEFERSAASKVERNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1P4</accession>
    <name>A0A2S5B1P4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000107">
        <property type="protein sequence ID" value="POY70676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1P4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="187" mass="21827" checksum="E657CEBA9053FBD3" modified="2018-07-18" version="1">MYPSATARFRTGRLFWRQISRQTRPARLPPRPRLLHQRVRYRQDSRHRRYLDSRWMLRFSRARGSCRPRQRARPCRSRCSAGSRSGGSMRPQRRSRAGPCRAVHLPATRRPLHLHPTPLRSSPRRVRSMRSLQRSCLPSSANACRTRFRRGAAGRGSISGRRSSRRRTRLCGGESRSWNGCWSRSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1S4</accession>
    <name>A0A2S5B1S4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear condensin complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1S4"/>
    <dbReference type="STRING" id="741276.A0A2S5B1S4"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="593"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="942"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="946"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="983" mass="109535" checksum="080B19EEF5EB2471" modified="2018-07-18" version="1">MPGRVRRADAQHDDTLETLADVLDQHLPAVFTAAQQTTASHRKHINTLHGVFLRCAKVTTLSSDGRYTRLSGEKAFGEKFREMATHPLGLKKGTDQADRVIKFIAGFVGFAIEHDFKQREANGEQDDDDVDDGPASRLVAQVLAFLLRGFQAKNKIARYRCVQLVALMINSLGEIDDESYKTLKSALLERVRDKEASVRQHAVVALSKLQDADEEVDNDSEDDSDDETAKGDKKSVTAVLVDVLNHDPAAEVRRAALFNLIPSPETLPSLLRRTLDVDTTNRRLAFAHVLAEIPPRSLSLKQRQTVLGRGLRDREEAVRKAAKKLVAKWAELLAQSGQDAEGIIEAFVGLFDVYTTDGKAIAEKALEGLFELRPDLIESIDLSDESFFQTLTPATALLVRTYIDHLRAQESSRLADVEPVATALAFYLQAAWTQLVVSLDADERDTDTERQLQFIVGELVNVAINLDYGDEIGRRKMFELMREMLQNPLLPPTLIPLCLDVLLKGTSERDFMRIVVEIVQSLRRDSHLVTSDSELGEQDEDDDIDGGAHAGSDSDRDGEPGDRDAAKKKASARRKSAVQTPQQAARRKDLDLRCLFVVKALLERVMSALQENSMLHGLVAELIVPAVKTKDYEVRAQGLICLGLCCLLDKSMALDSFQLLARQSESTEGELQVKVLQTLFDLIVLHGVNFGEERGFGSNLIIGFLGSSLDQEDPTAAATVVVGIAKLLLSGMVTDEEILSRLVLLYFASETADNPELRQCLSYFFPVYCYSNPENQRRLASVMVKSLDVLRTVYEDLKDKSTMVTPLQIGSQLVDWTDPQKVIDSEGIEPDETVQVDLAIRTLKALYRAEEKEARKLWCQLLPKLHVPEEADDSKIRSIMYLIDELKDNRPIADTVSKNALNRFQTALHKSFDERLDGLDEGARAAVEQSDDVKAIKAWVRKVEREESDESESAEEEDDDDDDAESEEGEEEESDASEEETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2A9</accession>
    <name>A0A2S5B2A9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2A9"/>
    <dbReference type="STRING" id="741276.A0A2S5B2A9"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="266" mass="29481" checksum="9DA3450E1A807781" modified="2018-07-18" version="1">MSADQDRAEAIYMAKLSEQAERYDEMVSQMKRIASLNSELSIEERNLLSVAYKNVIGARRASWRIVSSIEGKEEAKGNTQQATAIKAYREKIEKELAGICEDILSVLEQHLIPSAESGESKVFYHKMKGDYHRYLAEFATGEPRQKNADASLEAYKAASEIAQTELAPTHPIRLGLALNFSVFYYEILNSPDKACSLAKTAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDLSAEDQPKADEVKPEESAAAPAATGEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2C8</accession>
    <name>A0A2S5B2C8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell division control protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2C8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2C8"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57191" checksum="18F8D4DA3A968E1A" modified="2018-07-18" version="1">MTLSATKHALEEALDDLLSIRAPPAAHSAALTSLESVVTRVALASPSTRQLYSAFLKWQDTPTRNIASALLDWLGRVLVKCDLMSLAIESVAADLVKCLRLLQGLLLLHRPSQRFFQRRANLENLLMLLDLARPAHPHTPLLATPKPHPSPVLFPSTPTASPRLDSASSASPLASAEIATQVSLAALDALLCGLVDRPKNMRAFEAVGGLGAIVRVLKDKGVAQSVRIKVIELLFYYLMPEANPAQPDTRPSTSSDMSFASSTSSTSLDSQFLRHPERLPDVLSGAADFVPQTPIKQRNSRSRGEGPATPNRARSHADESSPTRTPCRSRSEASEAGTFGRSSDRSSDRGETTPRHRRTDSASGATTPRAEGKRADHHHRRSRSAVSVPDTLRDVGQHSHRQLSGSREVDVSAAGRSVDKSDMPPPPVPAARRASSSIRRSISQPPDQAFDRPRTPVERTSTPVSHNSAAPTTPTSRSRRDAGTQPEVARSKHLRSEWEKKELLRQVMPNVDALQERFRAMGLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2I1</accession>
    <name>A0A2S5B2I1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5918</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY70993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2I1"/>
    <dbReference type="STRING" id="741276.A0A2S5B2I1"/>
    <dbReference type="OrthoDB" id="4506189at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="43948" checksum="312CB1D25193A906" modified="2018-07-18" version="1">MSKRDRVTATSLVRLLDPLATYGQKSSPPSPDYLSLLHYSATAKQARKLVDALLAAQPDSATTAANRDLLYQLDSRLSTAEQQLARLAPTQSSSLLSPPPEVVHTYQDTDPLLSSDLANLDYLAVPPPAIPSFDFAGQAATREAEPPQVGPLPDDDPDTTEGDENGLLVQNALPKPSDFRNASWRSNGGPSSIRSPPPPTEDAIAGRPIGPGTSSSLDPALTTSTARQRRGQPQADDFTSGRPLLPAEKPVPAYLVAKRARAAAEKKRLAELEESDDDDDDDLVIPTPAKVAKKLDDLIPADAVPVGGGGGGGSGGDLLGQHHALQTSLLSSLTSLSGALKQSTLSFSDNLAKDKEVMTRAQEQLETSEAGMKTQQARLKEVRGKSRGTTCWTLGLLAVVFVLWLLTFLLIKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2P4</accession>
    <name>A0A2S5B2P4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_5985</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2P4"/>
    <dbReference type="STRING" id="741276.A0A2S5B2P4"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="59"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY71058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="392" mass="42096" checksum="31EE7F6ACBE97A68" modified="2018-07-18" version="1">MTLIRSALSAKHALRISKAAFSSSTAAASTAPYNPPSPYPTTSLQPHPHSLPVQGFVGAIGNTPLIRINSLSEETGCEILGKAEFMNPGGSVKDRAALGLVQWAEKTGRIQPGGTIVEGTAGNTGIGLAHVCRARGYKCVIYMPNTQSQEKIDLLRMLGAEVYPVPAVAFDNPENYNHQARRHAERLDNAAWVNQFDNFEGNRAAHIHTTGPEIHAQTKDLPGGLQAFICATGTGGTLAGVTRALKDLSGGKTQCWLADPPGSVLESFINRGVMERGGGSITEGIGQGRVTDNLKQDIDLLDGALHIPDADTIRMIYHLLDRDGLYVGASTALNVVAAKKLAEKLGKGSRVVTILCDGAYRYQSRLFSKKWLESKELLKEIPDHLQKYVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2X1</accession>
    <name>A0A2S5B2X1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2X1"/>
    <dbReference type="STRING" id="741276.A0A2S5B2X1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="490" mass="54121" checksum="33774047712A774F" modified="2018-07-18" version="1" fragment="single">SSASSQKRLRTLADIDPAVEAKLRRKIDRRILPVRANIGNAKIVHLERDLNMKGYDYNILLTAPLKHADIRRGHRILAPRLLPVSFYASYMVFELPCQMLTKWLGPGKTLPLFGFLFGLFTFAMAFVKSFGAGVAVRFFLGIAESAVFPGISYFLSRYYRKDELGFRLACYLVCTAAAGALGGLLASGILRISHIGWLTEWRLIFFIEGLASMVIAAAAWFLISDRPSACKWLTPEERELAEFRVMAENVGQHEAIDKMHSKAVKAGIWNANTLVIAIIFFLNCVQVQGVSFFLPSIIKSIYPERSVIVQQLLTTPPYVIGGFCTLSTGYLSWKTKRRGIYLVLSVPFLVAGFSLYLASMNPHIRYLAAFCVALGAYNFGAIVTAWTAVNVTSDTARASAIGTMVAAGNAGGLLSCWTMLPKDAPRYVPGNAFNLANSVVIFFLASGLILWQKRENKAKAAGRDDHRLVGKSACEIADLGQKHPDFRYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Z1</accession>
    <name>A0A2S5B2Z1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Z1"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Z1"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14715" checksum="454BE171DA8179C6" modified="2018-07-18" version="1">MRVSVLADCLNNIVNAEKRGKRQVLIRPSSKVIIRFLTVMQKHGYLEEFEEVDDHRSGKIVVQLNGRINKCGVISPRFNIRLPDIEKWVAILLPSRSFGYLILTTSAGIMDHEEARRKHVAGKVLGFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B385</accession>
    <name>A0A2S5B385_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B385"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="35"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="613" mass="66879" checksum="FB244B06AE39AA89" modified="2018-07-18" version="1">MVPAPARDRLADADDDPARPRPSTTLTGSGSDSTRPIHLCVILHGLWGSPAHVSYIKESLVAHHDDSEATRLAVFVSSANSTSSGHLYDGIDVCAERVVEEIDAEIERLEAEAGAGGKITKFSIVGYSLGGLVARYVLGLLDSRSPSFFGTVRPVNFTTFASPAIGMPQFDGYWASWFRFLGSRLLSRTGQQIHERDSFLSRDFKVGRTSGTSTPAAAARARGTAQEQDGEPLLQIMADPRFSFYRALCRFQRVEVYANTLNDRSVPFCTAALEAHDPFALACKRAIEAAEDAGESVDGVPDLARGGLHVTYRAGTPILESYHVSEAKEEAAASAAGAAAAPGGVVVAQQTRRKRMRFSLPPPFRPSTYPVSKPKALVVISLLPVIWPVAISFLATRSLVHARQSQSRIRLAQSKIEGGADGWLARVGIKLEELVERSALDEPGFADALDHLRERERDSDRQETATIKDVDEEPEGVREADEDLSPVVNEAQATSPRPAPRPSTSSSSSLSSGWTLAGGEDAQTALLEQDKRDGSHRQKYRMRDPRPATDPVLSDSQLFQLEHLNAIPQLRKHLVHLPEVHWSHGAIIRRDPNFQQHEKGKLVVDAWATEFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3B5</accession>
    <name>A0A2S5B3B5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5502</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3B5"/>
    <dbReference type="STRING" id="741276.A0A2S5B3B5"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2320:FF:000001">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="261"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="528" mass="58875" checksum="1A90CABBE5316713" modified="2018-07-18" version="1">MSGLPSTETLQLVVLHALEAHGAISDSRQLRLALPTGVETDEAVPLASLEQAGGNAPVVGPTVDAQNALKSALDSLATREMVSFKQVNLDQSVLTAEGTAIAQSGSHEYRVWSVLPPATAEQGLTAKQIEEKVGKDTAKVGQGKAMKNRWISKKGDGFLQAVDAVEDVTQKDLLAIQSTGSHSDDKLLAELRKRKLVEKKKTFYYTVEKGTEFSTTIAKLETDLTVELLNSGAWEKASFKKYNFEAEGTHTFGGALHPLMKVREEFRNIFFETGFTEMPTNRFVESSFWCFDTLYVPQQHPAREMQDTFYIKEPAMAQGFPEDYYERVKTVHEIGGYGSTGYRYPFSRDETSKLVLRTHTTSVSSAMLYELANQPGGFKPAKMFSIDRVFRNEAVDMTHLAEFHQVEGVIADYNLTLADLIGFMEVFFSKMGVKNLRFKPAYNPYTEPSLEIFSWHEGLGKWVEIGNSGMFRPEMLEPMGLPADVRVLGFGLSLERPTMIRYGISNIRDLLGHKVPLEMVEKSAAVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3M9</accession>
    <name>A0A2S5B3M9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3M9"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="346" mass="38850" checksum="670E3B467337AE4F" modified="2018-07-18" version="1">MAELTRRMMLSSLLGYIALGASVAAFVPIIMMNSVKRVSGTEPGLQLNLVGVIVLKAALTQKALAAWYLIADSIMLVQMLFFGHDDLKWRPPQPAKAAVRIENRKNTPWYHALTQQFMEFSIWDDIKLLGFCVMGGIAVWGLYLTLGLYNDPEHFAIEIPLGYHPASFWLGLAAITIFTAARIPEILSGHLLAETPFLLGAALPILFDGLMLGAISSWQRRWARLDTPAARQAKEAEAAEAEELDLLKAQQEDIIIEQRLRMLLADVEAELPEVPDNAKPKERHKIEAARRKIQLAQADYRKNESALLAVQQRLQHRKDQRARARRNLRKSSLSRPTLEEKTEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B463</accession>
    <name>A0A2S5B463_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000080">
        <property type="protein sequence ID" value="POY71558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B463"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="400" mass="42890" checksum="CFF2BAA2587C71FC" modified="2018-07-18" version="1">MSRELDSTPDLVDDLPPLPQRGPLAQIFASPLSQVVIISLICFCTPGIFNANSGMGGGGQLDPKAANDANIALYCTFAVFGVLAGGIGSLTLAYATEGAKGRYFGIFWVLFNLGGVLGAAVELGISWDSTSNSVSNSVYIALLAIAACGAFLPALLANPATVVRTDGSRVIPPVHPTWRKEVRGMWDLIKTEKILVALLPLFFSSNFTYTYEQSTYNGHLFTLRTRALNSLLFWLFQMVGAAIFGVLIDLKRFSRVARAWSSLVFLVALHMAVWGASCHVQRGFHRDDNFVRIDLKEGRYAGYGALYVFQGILDATGSWAPSPPSPLSSLASSVSTRASSLELAATWTVGVAGLIFAIPVVAIRLRKGSEEEIEAAAEVHKHDEVSLASGEKKEEDALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B484</accession>
    <name>A0A2S5B484_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000076">
        <property type="protein sequence ID" value="POY71592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B484"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="291" mass="32122" checksum="0DD11F6845F6309F" modified="2018-07-18" version="1">MSDSREAALEKLQQDLDEIKADATYKGKTAIAFEAFHDHALRIFGNGRLHAQRQLILEVVAEVVASLDHFWSEGFVERPSTTELYRRLNEIISKADAHLANNDALGPPREWSSVQASTHVPHLERTLEGMDWAYRDLGQKRGSPKAEFCRAVRSAAKRWAEHAADGANEPAQVKALDALQETANDLRDIRSRGERQGLLRAALVDALDDCIRDNEQRLLRLVQQAGIEGSPVRTGGADSAANTLSTLSLLDQVTWPNLVRTSLYRGKSQGTAIRPGPEGSSIRSACRLGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4J4</accession>
    <name>A0A2S5B4J4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5292</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4J4"/>
    <dbReference type="STRING" id="741276.A0A2S5B4J4"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="302"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="575" mass="62276" checksum="E3EAEBCC70D0AD93" modified="2018-07-18" version="1">MVSFPPNQSTTNPLPLPTHTQLPTSDPADDEDAEGDDDMNLANAPLSTGKRKGGDRYGASHPLKSLTPKRIAAIAAGLLFLIFFFGRSTGTFSSSRTGSGSDIPDEAAVRLDKLPPNSPQKLPSANSGQCTPPPGKKAKSYAIMIDAGSTGSRLHLYTFSHCDPDPKALPKLEDELFVTTKPGNGLSKFKGNPNAAAESLRDMMQRAVDAVPKSEQSCTPLAVKATAGLRLLGSKDSQAILDEVERWLKTEWPFPVVEDGVVIMDGRDEGVYAWITINYLLGLIGPGQPASAGTAAVMDLGGASTQIVFEPIFDPVTKDKLAPGDHVYDLDFAGARHVLYQHSHLGYGLMQARRAVHNLVAYSHVWLSPHKGSPIDWDSLSEKDKIHNPCMFKGEKKVVTLDPPGRNEVQVTMEGTGAGFEACRRVVEVMIAKDAACEEPPCAFAGVYQPKMGEVFAAGKVWALSFFYDRIAPLGLKSPFSISDLRQLTSDVCAGRKSSAWSRFKGNKEAMAELTDRPEYCLDLTFMYSLLSLGYELDEERQIWMGKKVSDVELGWALGAALAMIEGHLSCRADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4K8</accession>
    <name>A0A2S5B4K8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4K8"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="169" mass="18036" checksum="9AE78D8339CF365E" modified="2018-07-18" version="1">MRKRNPYTAKDDDDSTRDEPEILDETEQDSLAKALLAEALVAQKGYRAAALVLLTCAILLPQAELPVLLALVLRLSLSLTIVRLGHGIWTTGTVPSPRAVDLVLLIAPALTGASAFLSLDPASSTTPSRLVRALPLFLQLASVWAAQQGETLVRDARGLENLKYSAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4N5</accession>
    <name>A0A2S5B4N5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5110</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4N5"/>
    <dbReference type="STRING" id="741276.A0A2S5B4N5"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="309"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="690"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="909" mass="99270" checksum="41FBD59BA3229CDC" modified="2018-07-18" version="1">MDPLPLEDDQLTTRTRRFTEFLDLDPGSAQARRMSMAYKPAVRKMCDARERRLVINLDDLRDYDREFCDGLLKEPAAWLPAADAALKDMAINTASDRLAEVVKQETFAVGFKGSFGDHHTTPRTLKSEKLGKLICLEGIVTRCNLVRPKMQQSIHYCPATTNFHTRIYTDRLSSAAASGAPVSSSAYPQTDADNNPLEIEHGLSTFIDHQMMSIQEMPERAPAGQLPRSVEVVLEDDLVDKCKPGDRLQIVGVYRSLGGGASGSAHFKTLIVANNVVLLSAKSGAGIAQQTLSDHDVREIRKVSKRKDAYELLWKSLAPSIYGSDYIKQAMLLLLLGGVEKNLPNGTHLRGDINVLMVGDPSTAKSQMLRFILNTAPLAIATTGRGSSGVGLTAAVTTDKETGDRRLEAGAMVLADRGVVCIDEFDKMSEIDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVVAAANPIYGQYDVHKDPHKNIALPDSLLSRFDLLFIVTDEADEQRDRQISEHVLRMHRYVQPGLEPGAPAFDSLEQHLSVGTEEPAAGTTEANPSPFEKYNPLLHGGLAASTAQSRKKGKKSKAPEVLTIAFVKKYIQYAKSTIQPVLTTEASEHISKAWTNLRNDDAGPNQKRTSPMTVRALETLIRLSTAHAKARLSPDVLEEDAAAAEEILRYALYKEVVKATKPNSKRRKLNKPRRGDKGSGEESSDDGDSESSDDDEDDGRGPKRMDMPGQEKRPSRANPARGARSGARKTASPGAASASGEEEWMLVEQQEREAQAAQQAADDMQDDEDEEAALREAEQERSPSQPPAATVSADKIAAAAPTQSGIDPARFKLFQTRLAAVRKSDEFKDSDEITLNSVVEPLNAGLPVEDLFGRGEVVQLLEALGAQDDSVITFDEGVIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Q2</accession>
    <name>A0A2S5B4Q2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DCG1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Q2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Q2"/>
    <dbReference type="OrthoDB" id="2534206at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="27935" checksum="1CC36D95F90DD43F" modified="2018-07-18" version="1">MAASLASLARPILVINPNTTKAMTDGLEVALRPLVEGGKLPTPTYMTAASGIASINNSEDCHASAEAVYPSLVSTASSSSHPSILSQHSAVLVACYSVHPLVPRLSALDPNKPVLGIFEASILASLAVCLQPQDRFGIVTTGAVWEEILSAGVRDFLGQPRGTEARGTKFAGVETTGLNAVELHTTPQDEVTSRLKEAVKRLIRRTKADGGDLRAVCLGCAGMVGFDEAVRAGCIEELGEGPARRIQIVDGVKSGYVMLEGMVRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Z2</accession>
    <name>A0A2S5B4Z2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Z2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Z2"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="190"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="609"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="863"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="883" mass="98414" checksum="3BFB19203FC825FC" modified="2018-07-18" version="1">MTQLRRNPAQAANALKPEAIVLDSDSDQDDANGADTGETTPDSPKAEDDKDFVPRDEEADRQEADEAQAKPEKEPQATRPKTEQEAKKLLRQALLDVVQKTRVYTDAIEKARREAAAAQGLPEDDDEETDDTDGDTSTPGSKRGRRSKGGAGPKKKRKKEAVPMNFAQSKLISGGTLKDYQLDGQNWLIQRYLFAMHGAILADEMGTGKTLQTISLLAFIHENLHKAEKKSTDKPSIVILPKAVLYNWAAELDRFAPELPVLVYTGTKDERADIRRSRLGLRGLNNQPPKTRKDPMPIILVTYNIMMNDIAWLKELKYDAIICDEAHKAKGLHGRTLASLKQLQGDFRLLLTGTPLQNNLTELYALLSFILPHVFNDRELFESQFDFSEITTSDGSKLSEQQEVTLLVAQLQSILKPFLLRRCKKDVIKDLPLKKEYVLTAPLTARQKEMTEAAVNGELRDFLSGNTPSASSTRESTPGTRTRRRRGGDAAIIDLSLLKDDDDSTPRRRTRGARKSYVDALPDAADDDEFEEQLHERQQREALAEQQVALQKATAKASTATSLLHKKTKWNSAMTNLRQIANHPLQKYDDREQNADPETVVNLSGKMMLLDRLLPELFKRKHKVLVFSQFTTMLDLLDEYFELRGWDRYRIDGRGGQGANHDEIAEFNETPFSKKSINLFLLSTRAGGVGLNLVGADTVIIFDSDWNPQNDLQAMDRAHRIGQTKPVLVFRLASANTVEQTILASATKKRKLERVVLGNDTLAGDAQDILNKAKGRKTGGSAKRKDEAMRELAQQLLQAEGERITLADAGAEILSDEQLNTLLDRSDDAMKSTDSSDAKKGATFEVVETIEEETVQQNNILDDLLGDQGDRAASSTQTSDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B518</accession>
    <name>A0A2S5B518_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histone acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_5240</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B518"/>
    <dbReference type="STRING" id="741276.A0A2S5B518"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15670">
        <property type="entry name" value="ePHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05839">
        <property type="entry name" value="PWWP_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="135"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="189"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="484"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="15">
        <location>
            <begin position="946"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="648"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="786"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1061"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="862"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1077"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY71879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120424" checksum="295529D98DA4CCFB" modified="2018-07-18" version="1">MPGHGGGGALPTVKFTVVEPAATVPPDVGNPQLATYGYHDGKEWSAYQDTVAHGDGGRYLRWLQPTEADLAKQVEYDMDEQDKLWLDMVNSERKRENHSAISYEVFEIVMDKIEKEWFDLTRNIPKRTNAMPNEDSKCAICDDGECENSNAIVFCDGCNLAVHQDCYGVPYIPEGQWLCRKCTVTPDKPVVCVLCPNSYGAFKQTTTGQWAHLLCAIWVPETGVVNTVYMEPVDGLEAIPKSRWKLLCYLCKKRVGACIQCANRSCYTAFHVTCAREYGLELKMKQGLAPGGDLKAYCDKHGEGSGASRGGSPLPSTLRRHKAGPSSNLLKLTLRLPNKGKSARAYKSTFNSGPPVIPAKIFDRVMLYIGKLKVNGKKDVVNLVCRYWSLKRESRRGAPLLKRIHLEPWTASATSRQQSEQDKAQKLGLIRLLRNDLEKVRMLTELVRKREKKKLERAKHLKAVVEEMLFPKEGAMRKVLQSVKSLDKTAYFSQPVSREDVPDYYEIIKFPMDWATMSAKLDRHEYPLALDFSDDIHLVINNARRYNKEGTPVHKAAVKLKEFVEPLLADLEALDERLSDPNILSHYVSQILTPEDLDDLFAFDYDTNDPEGKKAQAAERRAREAVAAEEAAAARAAAAKIAATEEARRDAEEAEVQSNANTKGKAKGKGKAKARDEPKPEADLPTAMDVDVALPGKKRNADEAGLDGTPRPRARATRSSGIVAVELPLPPRDKPAGSRATPARDAAPVASNSRASATPRSPMKPMPEILADEEIDPKATFQHFETGWILPAGSRRRSSVGTSTSASAPPRKTPRAETAALPALPEDTPASAVAAPEKSPAPSSKARAKTKGKGKMKAEPEPGPDEMQVDVEEAPTEVAKAPRPAHAKKPRGSLAVHAPAELKEWEQRFNDLSAEVMVGEKTKAEDGECWSLRVSRWSLLTRPHFIGTLVWAQMKTYPYYPAELVDPKDKDTPQWLVEAQTKNDVNKLPVLFFDDARSGGWIARSSIRLLGESAELDKHLLDPLAVRYIRKLKNDKNSKGTAELVQKLVKAYDTAMSLAEDETDRAAAEASQVKTAGKGRKKAPRKSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5B7</accession>
    <name>A0A2S5B5B7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5B7"/>
    <dbReference type="STRING" id="741276.A0A2S5B5B7"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="290" mass="32997" checksum="3EB187455446F41A" modified="2018-07-18" version="1">MPNPIGAGPVHQLLHALPIPSLPANIERWIPGSTPISTTKDVALAVSVYLALIFGGQDFMADRPAYRFKPLFMLHNFLLSAGSGLLLALMLEEIVPIIWKNGLFYAICSNDAWTPRMETYYIFNYFFKYWELFDTGFLVIKKKPLQFLHVFHHTATAVLCYTQLNGRTSVSWVVITLNLFVHVLMYYYYFMTAAGYKIWWKKYLTTLQITQFVIDLFTVYFATYSYFSAEYYPSFPTMGSCAGTEGAAIFGCALLTSYLFLFIAFYQRTYKKPAGAAAKQAAAKVAKKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B612</accession>
    <name>A0A2S5B612_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B612"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43335" checksum="24FBE045BFB0757E" modified="2018-07-18" version="1">MSPDPASVCTEQRETVVTWLVEETQELIAKAAKGEKERVNYPKTIEGGAWQLSIEVDTVQISLDCSAYVSSAKGPELTRQSLRYTSTPSEAKKSELQGRGWAGFLNEQQIRRIEGKKTISLAPVSAPSPADTFAGDHTDFGPFLLDAGLPEEQTTLHAIDNVPSSTSTDKTALSLASNSSNMANGRRTFRCIEIPDCSLPHLSVYASYSTLRSFLYFLHTNEISFAPSLAHFFADAAETSSDSKPTSAQSRRWLRSKERSSLPEVGNAHALYRLGDCYLHEELKRRAKNAILENITVNSVSRVIDTIITSQAPFELFSDLSHDYEDVRIPILDFVAANMVSMVVFGSVNDRLEATALQTLVRKTPGWKRIMKLIDAGEVQGGGTVLNKLLNGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B634</accession>
    <name>A0A2S5B634_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4756</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B634"/>
    <dbReference type="STRING" id="741276.A0A2S5B634"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31587" checksum="1325E15178269B89" modified="2018-07-18" version="1">MALNIIHWLGAFLYFAAMVLLVIVSVSTPIWDNVGFLKGTLNGQSFHAGVWGYCFGGVCTKAGFGYDQARLAQLTGTNAAANAIRYTYSKTLILAPIAAGLAFIALLFSLSTHFVMGLIASIWGVLAFIATVLLLGLSLGFFISLRNRLNDNVPNTNVGLSYCVWFVVAAAGALLFGMIFVCFTRNRRNKRERKAATYATEYPAMRSTANETPVVSEAHYSGAASNVASEDPLVNNRTSYAPTTGTHTYGNAGTMGTDPTYGGVTSTYDHAAGEPVVGAPANGGHWWQRQESTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B786</accession>
    <name>A0A2S5B786_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B786"/>
    <dbReference type="STRING" id="741276.A0A2S5B786"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF452">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015373222" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="526" mass="58332" checksum="6433C0C05CA6D1F0" modified="2018-07-18" version="1">MRSTWLLSPALAATALALPSQLTFSSPANGLGQLDLGSALKDAWNGIQRSQPIGWLEEGVREFSTRVQDSGISYELIQHADFPAHSLRMKQPKGLCDSSSKSYSGYLDIAEDAHLFYWFFESRSKHPEKDPLVLWINGGPGCSSTTGLLFELGPCAVANGGLNTTYNPHSWTESANVIFLDSPVQVGYSYGSKTVSNSQDTAEDIYSFLQLFYEKFPKFQNVDFHVSGESYAGTYLPNIASVIHNHNKKKPTPSSLTIPLKTVLIGNGLTDAYTQFASVPDWSCNKPKTPGANPYGPIFDESTCSSIRGKVPTCQRLTEFCYNNPSRFTCVPATLSCWQVAGPIQQSGLNPYDIRKKCDRDGEDGPLCYKQMQWIETYMNQPDVRKELGASPDRTFESCNMQVNQAFQFQGDVSHNTAALIPPLLEDGIRFLIYAGSADFMCNSKGNLQWTLAMQWSQDKKYNKAKLLPFKSNGKRAGSTQAVTLDGGAGLLRYLEIDDAGHMVPYDQPEASLDMFTRWIRNESFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7E6</accession>
    <name>A0A2S5B7E6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7E6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7E6"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="750" mass="81683" checksum="1D3CAA187F49214D" modified="2018-07-18" version="1">MVASDQSVSPSGTDDRGPSKKRKMRPRVSCGFCRRRKLKCNLETPCSSCLAHNEVCEPLQRSDKPRPTHSRIAQLEEEVNTLQAFLNRLALGTSEQRAIELDEWHKTGIVPGASGTTTTAAAAVASAATVSSTHESPAMSDTRHASDGEIRDPISRLHIDSSSGHATSHGPTSAFFDGSFASASAGRQLLSDSDIKSRLMTFNAEQRHQEMIALATGKLDFDGVAPELAMHLLALHWNRQHHAFLVTYRPLFMRDMSCGGPYFSKLLLNAIYFSVAKFSKRPEVFDDVDDPRTAGLRFLRRVKELLGEALDKSRIPTIQALLLLSSSLFALGWQSAPWVYSGIAFRMLSDLGLNHDWRSRVVKGGEVEPADLEIRRRLVWAAFVFDKIISLYQGRAVTLHEFDIKVPAVFLDLYEEQEPWTPFAFSSIGTYTSSPSYSVSTFKELCSLSVIMGRIINTFYAERICPDPLQQLAALNASLAEWSENLPSYLKYDPSDGVAPVPPPHVLSLYSMYYTLTVLVNRPFLESGHLQSLHAPVAGDCWSRCETAAMKATAILIRYRETFALNRAPYLIAYSTYIAATIMVRTAAQQGPSSDAARCLEICINGLQENAHVNTGARKTLAIIQGLVERLNVARSGEAIDQHAHEAARAGGGVGGAGGGGGNGQPMALPSHSGSSVDIDAIMNSFNFNQGMWNLPLYNDPAAAAAAAAAASSSNTWPQDSLFGISLLGWPGETGGPLDENWMGYQGPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7N4</accession>
    <name>A0A2S5B7N4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triacylglycerol lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7N4"/>
    <dbReference type="STRING" id="741276.A0A2S5B7N4"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="45674" checksum="B3D72D2FA57A9DE6" modified="2018-07-18" version="1">MLGTALDFLRVFSLARPQLPTVDSIAPLYDTIFSFGDSYTTIGYDPNQGINVVPDVGGTSSGGNSWPQFLATADSNRSIALYDFAVGGAATNNSALYFAGQEVSIPDFPQQVATFEDFFSNPDGTAIKSGEAAWRPERTLFTVFFGINDVGLEVRNQEDPRAELPQIFGELATTSFLHHRVHHWMSTARGRAQSGVAQNEVFITKLKKSFSMLITSPILSCPATWSRMIVKLYASGARNFLILNIPPTQRTPFISALPERILAMYESDLNGYNVVLSDFVRTIEPAYNGTRVIFFDAHAVFDEILDKYADYGFTDNSTFCELYASIATQPALDLPQCGRPLAQYVWWNSGHPTWPVHQILASRIAAALLANASTTASSDVPKLSSNETTVPLGKSIRTASNLLLASALAAAIATRLNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Q1</accession>
    <name>A0A2S5B7Q1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_4194</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Q1"/>
    <dbReference type="STRING" id="741276.A0A2S5B7Q1"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="636"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY72785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1186" mass="130935" checksum="BA59F7B44668F401" modified="2018-07-18" version="1">MSNNMDVDNEGAQPEQRPRSTSPLAFPSSSAGGHPSSDARPATVDRLRSTGNGVRSSSPLAFPSSSNAGSARRGGNPLFNASQQPSSDVGRLLGSGSGAARAGRDDSPLFFPGSEFGSPTPRRNIRGDIHSAAPPTPSNRSSAARNRRNVATSNAGSELGFPPSSAASRRRGNTAPMTDGDDAQDQQGEDDEEDDGLVTVLWGTTVTIGASMKAFEWFLKEFTCGDRQTFDPWRQEQARIKREELDAKMSEAHLRGELDTVAMLRGQLAKVPLESEIDFAYTKERPETKLYQRHLERMRDTGQTNLNLDVVDLLAFRWRETQQGGAIRDREDREYAQLYRNFLLYPQELVPILDQQLKDSALEWACAEENLGEGPTRLENEQRAREMHGAVFKVRPYANETRVNMRELNPQDIDKVVCIKGLVIRATPIIPDMKLAFFRCNACSHTVTVEIDRGKIAEPTRCPRDVCNVQGSMMLVHNRCEFADRQIVRLQETPDSVPDGQTPHTVSLGLYDELVDTVKPGDRVTVTGIFRSVPVRLNPRQRIIKSLFKTYVDVLHVKKTDKRRMGVDGSTRSADDRRGVVGVGMEDEAEAPGGLHDGPETDDLYGDEAMNEEERQATAHAKLKERLVEISRRPDIYDYLARSLAPSIYEMDDVKKGILLQLFGGTNKSIAKGGGAGGPRYRGDINVLLVGDPGTSKSQILQYVHKIAPRGVYTSGKGSSAVGLTAYVTRDPDSRQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTVSIAKAGIITTLNARTSILAAANPVGSKYNLKWPITRNIDLPPTLISRFDLLYLVLDKIDDKSDRMLAKHLVGLYLEDKPETAGIDIMKIEELTAYISWARNHIQPVLTADASNALVQAYVEMRNAGTDSRSNDRRITATTRQLESMIRLSEAHARMRYSERVEVEDVTEANRLIREALKESATDPLTGLIDLDLLGGQSTHQRKLRGDLRREVVTLLGSRDKGFKWNDLVKSLESQSSLPIDHGELTEVIKGLESEGSVRVSGSAHARMDTERVLSSLKYYNNSGSGEEHSELYGYSQAVVVGDVVKCAGQGGWDNSGNLEGYDFEMQVRNAFMNVERVLAAAGVKGGWDAVYALRTYTVGPPAETNEPLITMLKSKTPKHRPIWTALTVSELAFPGMRIEIDVEAYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Y2</accession>
    <name>A0A2S5B7Y2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DExH box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B7Y2"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001714">
        <property type="entry name" value="ATP-dependent DEAD/H RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF203">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="496"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="767"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1306"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1386"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1308"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1340"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1354"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1389"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1407"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1433"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1447"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1471"/>
            <end position="1492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1499" mass="160625" checksum="5EBD6A2E230D02B5" modified="2018-07-18" version="1">MAPTSGSRGGYRGGRRGGGKPGGRSNGGGTPAAPPPTVQGPVRDLSYLEKTYGAKALPVGSKYLENPKGVIANYVKALGLDPVYNTQKCTVDGKVLFRATIVADPDPPPPVQRSLGYNSASSAGPSLPPIVQPVVGTGDGPNAKDAEKLAAIDACLQMNQRGLFNKSNLPTRSVSLAPVYPTPNSYQGPGPQYSQAAPAASSAFFDGPSAGGSAYAMPSAAHMAGPMHVPSVQVPAGPVPGANDGRRVVLRNGAVITLEEARAFMDYYCNRFGFGKPTLTYNSLPTRGRGGGQHWRATLVVKGMQIGIGEARVKKDAMNRAYLDTASYLDESDPSLWAAWEMKKLDKKVEKGDVQAHVVFEAPGDVEDDLRDAVYESGKSELYTRAREMIKREHEKAERRREAAMLARRGILPDDVDGDGDAAMRGQYEVDADGNPTRAAELAKKRAESRRTFLEKKSATLAQRLQDYKASEDAPIVKLRNQRASLPVSSHASSVLAKIATSSVVVVLAATGSGKTTQLPQLLLDNEILAGKGAECNIVCTQPRRIAAISVAERVAKERGEQIGDSVGYQVRFEAKPPKKDGSILFCTTGLFLRRMQADLEQAEASKSGGSNAPKGESFLDGVTHVCVDEVHERDVDTDLLLFVLRRLLWERRKQGKKEIKVILMSATIDPRLFTEYFADPDTKMLAPVIEVPGRSFPVEKRWLDETVNELEKLRLRPNEGGWVFQDKSVVQYLERELVPTIPFDPRTGRAVGEIDDLDMPYPLLALIIAHVLTQSDEGHVLVFLPGWDEIQSVRNILLDKNRYPLFGLDFASSRDLEIHVLHSSIPLAEQQAVFEPPREGVRRVVLSTNIAETSVTIPDVVYVVDSAKCKEKRYDPERRLSQLVSAWTGTSNVLQRAGRAGRHRPGEYYGIVSKARFASMDIHQTVEMLRTDLASTAMHVTGLQLPGLSVFDVLSSTIQPPEPQRVTAALETLLHVGAIDRDEKLTSLGRVLLQLPVEAAIGKLCLLGSFFRCLDQTLTLAAILTNRDPFLSPPAMKAEADRIKNTWAPTDFRGDPFAILQAYNAWWDMQGRGDYNAANAFCRDNFLSKPTLLLIQKIKDHLLSSLDRAGALQISAGGGATAPPPAFGRGRFGRNAGSIIPPQLNENGNSLPLLAALIATAVAPNFAIRVSEKSLRTSQDRACAIHPSSVNSRKNEKAADAPVTSSKQLYAFAEKSKTGAMGGKGEGQTFLRGTTRLDPLGYMLFGAYSLEVTTEGLECDGWLPIVAPRPDMVSALDDVERLKDILDLSLLRVFEGLGVAITRGRGKGALTGNGGKGGNGQQQRGGGPNNKGRGRQFDRDDEDENEGDDDAVDAEHDPTLSEQEVKDLDVLTGNVSRLLDSYHHALGPTTTANSRANSRPQTPQPLGGGGGGGGLFGPSHPPSSLQISSVAGGPGGWKGRAGGAGSAAPSTASSRSGTPYQSRPSSSAGAMGGSSGRGGSGFGSGGGGGRASSGSWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B822</accession>
    <name>A0A2S5B822_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_4004</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B822"/>
    <dbReference type="STRING" id="741276.A0A2S5B822"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="167"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="314"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="584"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="761"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="836"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="881"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="886"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY72928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="933" mass="102989" checksum="3224A4AE389A70FA" modified="2018-07-18" version="1">MMLDINRKLLTRCARVNTGLYTGNVIIYHIETGAVIKTFEVTEVPVRCVRFIERKNWFVCGSDDFHLRVFNYNTGEKVTALEAHPDYIRCLAVHPTQPLVLTGSDDMTIKLWDWEKGWKCIQVFEGHTHYIMNLSFNPKDSNTFASACLDRTVKVWSLGSPVANFTLDAHDKGVNYVEYYHGGDKPYLVTTGDDRLIKIWDYLSKSCIQTLEGHTSNVSFAIFHPSLPILVSGSEDGTVKIWHSSTYRLENTLDYGLERAWCVAYGKKGNDVAFGFDEGAVVVKIGREEPAVSMDSAGKVVYARNAEILTVALQQQAADEEAIPDGQQLGIPSRELGNTEVYASTLQHSPNGRFVTVCGDGEYIIYTALAWRNKAFGQGVGFAWATDSNTYAVREAGSKIKVFRNFKERPGLVQVNYPTDGVYGGPLLGVKGMGFVVFYDWETGAIVRRIEVNAREVYWSGTGNLVAIAGEDSFYVLRFDREAYQAGLEAGGPELDDEGVEEAFDVETEISETISTAKWIGDCLVYTTAANRLNYLVGGQPHTITHFDSQMYLLGYLPHHNRIYLCDKDVNLYPFSLSLSVIEYQTAILRGDLDSAAEILPSVPHDQRNRIARFLEAQDLLPLALEISTDADHKFDLAIQLDDLETALSLARSSPHLGSQAKWRTVGDRALAGWKVQLAEECYKQANDLSALLLIYTSTGDRNGLEQLVERATAAGTYNVAFAAALQLGDAPACVETLLATDRAPEAAIFARTYAPSQAPNAVRQWKKQLESAKKGKQANAIADPSEHPDEFGEGWEEALDRERAGPSTSQQQSQYGNGDLVQFDEGEEAYAAPQPATNGAHAAYEQPDEDEQGEVYDDGYDEQQQRHVENGVASLSLEQQHAAYSQQGDGDLLGSDQDLPPPVPLVNVNVNGDAGKAPPASFQHDDEEDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B824</accession>
    <name>A0A2S5B824_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4126</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B824"/>
    <dbReference type="STRING" id="741276.A0A2S5B824"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="189"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="531" mass="56667" checksum="906AA5C5E4812F94" modified="2018-07-18" version="1">MAAIAASLGTAAHSGRRASHAAALRGALLFRPQLAVNVAWRAALPAPARPTWATTGGARTFASSRTAAGWFGTSTTATATATGATPPPATAEAPATPLESMPSEPEPVVQATSTLPTPTPTPTPASVTETATETASEATQHFYDGIATGSLDLTSLQGAWGPHPILRLESLFLHLHEHFPLLGSPGLQWAVLIPVVTLGLRFLLFPFLVRSQKNAARMATIQPQMVKGMQRAKEAKAAGDVHGQQMAQLEVQQLMRANKVNPIANLVFPVAQASVFMTMFFALRGLSGSGIDSLHHEGFGWVTDLAAADPYYILPVASTALTLLSLELGIDSNTQVQTAMTKTMKGSFRVLMILGLFVIKDFSAAILLYWTTNNLISLLQTLTLKVPAVRTLLNIPTPPPKPQPGDPNYVPEPSFAEAFRNMQSSAMEKVDKTREETHKLAKLRSEFEAHQTGSASASSGVYTPRKPLNRPVSKGGVRDLTDELLEEAKGPAADLIQARPAAAAADAQLGAVEAERRRRVAEARKRRLQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8B0</accession>
    <name>A0A2S5B8B0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8B0"/>
    <dbReference type="STRING" id="741276.A0A2S5B8B0"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="365"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="457" mass="48860" checksum="FA7AFA6B17B2FAAB" modified="2018-07-18" version="1">MSSPSSLPTRAEELSVDSAANGNEEISTALFRPDEGWKEKLAAAGRRAYPRAVVGGDAELEALAWDLDDDEAWPKDPQKATDPATRGTAGDSPRFKPGRVLRSHLDAVRVVKVIAAPAAAEGDHAVEAVSGSDDCTVKIWHDLIGENKYAAALLYRYIGSRPITALGVTESDATGSKVIVSGSLDSTVCIWRYPTAERSTYDPVDELVLLGTIETHGDAVWGIEPLRNDRFACITADGSVQIWEWPTCTLVRSWQYRASNPNLRGSVSKKPPSVQIPTAMALFDAQDGTEQLVVAFQNGDINLYDPKVSERELRTLVSCESADGTPERQINSLAVDLANLRLLVGSEDRSISVFSLTDGSRLCSFTAHLDGVTSLASLSSDILVSASHDTSIRIWSLTDGGISEATDAASARCIQDLQAHQTKGAEGVLVVAMSAGHLQPVLVSAGADGTLRVWCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9B7</accession>
    <name>A0A2S5B9B7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9B7"/>
    <dbReference type="STRING" id="741276.A0A2S5B9B7"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="519" mass="58039" checksum="FABB10CD5E67A131" modified="2018-07-18" version="1">MSEEPSSSRVPPHPQLPPRNLCLFFDGTGTAAFFDRVTNVATLFSLASDCDDTQRVYYQAGIGTPIAHSGGWQLWPRQAISWLSGEIDQAVAFSLSAHVQRGYAFLMNNWRPGDRIFLFGFSRGAFTARALAGMLYKVGLLPKGNEETIQLAYSLYKRKSMRVPSGLAPEPAALAFKRKFCREVDVHFLGVWDTVRSVGAVIPRTLPFAGGATVIHHFRHAIALDERRAFCKYQPWLGREADARNVGYSVKEVWFAGSHSEVGGGAFPYDGDQHALLAHIPLRWMAREAVEQGLVLSPERVKDSPVFRPSKRLRYQPTELLRYDCLASTTSPPGGPVSATRAASYPPSDRQIMERVFEAADQLLWTHESASAPRTDCLSFRLAKTVSEESRPDSKRFRRAKTFSSRLCRRIGAAAWWLPEFLPHLKLVEERDKKGYPKLRLNLGRGRKVPRDATIHRSVLDRINADADVLQMQHAVQQTGVKERSAKEGGVKEGGAKKRGGQYSPRARFAVWPPQLVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA06</accession>
    <name>A0A2S5BA06_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA06"/>
    <dbReference type="STRING" id="741276.A0A2S5BA06"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="88" mass="10007" checksum="A1DAC11EEBFEA495" modified="2018-07-18" version="1">MSAQQPAQQGLEQFDEATRRELQTFLEQEQTKARLQSQIHTFTDTCIKGAPGARFSRGEEACLSNCVDRFLDSSLFIVKSLEERKGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAF9</accession>
    <name>A0A2S5BAF9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A/B superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAF9"/>
    <dbReference type="STRING" id="741276.A0A2S5BAF9"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="777" mass="83743" checksum="B4989B761C65FAB2" modified="2018-07-18" version="1">MGGRPPWFTVLSPRAQSYEGVKLARLRRLRLPVGPRPVLPRGRMTPDSKSTLSTSTRSRDTEPRETSGEPPSSFATASTSLQKPPVALLSSATPHLSPSSSSPLLLESLSRSSLPAASSTESHAKWVDWSKPTASTTFPASPDLTQLAGTPVPQATRHDKAPAPAHTTGAGADASERPKPSFRRRSASVGSLQALIDRDRDRSGMAGLGQAATHRRKSSEYARRAAGTSREPRTPSSSSTGVKTPNIGEGDVAQLSWGRWWPFAIVEPGDKSSRPPPPPPAKDAETAANRDFLALFAGTQAVEEARRHQAERAEQDRLEAELLDASLEELDLSAGSLALEADEVTSDRSSPRKRDKSLPLPPPPDADSSPTRSNTSSYLPSMPSLPSLPNLFSSPSTAKSNPSDTNAASEKGATGPSLLSSFAPSNPFASSASRSSSSFFPSIGSSRSPPRSNGARPFSSTATNKKDQDDSPDTKASEAKKMVDGDDRETIQQEQQVDLDTFSLLKDKYRTPKLPIVFCHGLFGFDYIGPAAVKPLRFSYWIGVEEALQAMGVEVMIGRVPASASIEERAKVLCQMIGEKFPGQDVNLVGHSMGGLDGRFLISRLKPTNFRVRSLTTISTPHRGSSFADYLLEDIVGVERVPALLGAMSALGVPGGGKAFDDLTTTKMARFNEETPDDPNVRYFSYGAYFEPSWSNAFRIPWGVVYEREGANDGLVSVDSAKWGDYRATLENVNHLDLVGWIGKFRYSFAAWSGNDIKFRPVSFYCAVAEQLADEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB50</accession>
    <name>A0A2S5BB50_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2811</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB50"/>
    <dbReference type="STRING" id="741276.A0A2S5BB50"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="538" mass="57595" checksum="76212D68CCE39B8D" modified="2018-07-18" version="1">MLRSRNVTAARQRLEAWTTGSYRSNAGHASSSPRNQPCRPNHSAATPSAGSLPPRPPRNAPQPSVKLVGGTSTVDKSTPSPPDAPPPKPSTGELLDVLKDTIKAHGPMPVSRYMTLCLQHPTLGYYTTRTVFGKEGDFITSPEISQVFGELLGIWYVTQWLAQGAPSKVRVIEVGPGRGTLLADILRTFRALPEHSRPPVSSIHLVEASEQLRGVQKLKLATTGFAETKTVWYGDIKEVPASSDEFTIFIAHEFFDALPIHNTQNGWREVLVDVADPKAIVSSAKAIDPLRLVLAPTPTPASALYSSLAQAIFPTVAHQQSPDLSSAAPAPRPSGLLNVDTTLGAQVPPSPRSAPAQVEKATSLIAQRFARLPIGSRLEVSPASWEIARDLAKLLGDGEASPGGAGLVVDYGDAKAFGRSWRGFRKHQVVDPLTEPGHTDLTANVDFAYLAEAMSETADTPGPISQGRFLTALGLQPRLAALLRSAPTEERRKEIESAARRLVDKTGMGEQYKVMGVVPKGKGQGVGEEAGVFPFNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBQ3</accession>
    <name>A0A2S5BBQ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBQ3"/>
    <dbReference type="STRING" id="741276.A0A2S5BBQ3"/>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="606" mass="65151" checksum="3CB8979B762F0A80" modified="2018-07-18" version="1">MQTVHKTMAKPTTEHLEVAENRAVHDSYVVDENNEQITVLGTYGQDPDEKKTISWRTIIIFGLCALAQMQNTYLGIAPAANAYAITGAIGGNSGQRIWIVQAQGVPSIVTGPIMAIVSDVYGRRWVVILAWLLFCVSAIVSMTAKDVNGVIAGQALAGVSAGISGIMYAVASEVLPSVYRAYAQTIVNVVSSAAAVIALIGMGRATAADPVNGWRWVFRTMLLYDGILLLGFFFFYHPPPRTVTTGSFWSKVKTLDWIGYFLLIAGLVPLLMGFAWSSDSTIGWHDPHSYVPVAIGFVGLIACLLYEWKGTTRGFLDHRLFQNGRNFPLSMFLIAVEGSLFYLVNNIYSSEMNGLWAMPGTIDANARLLPFFLVIFVVAPIMSYYVTKRKDLKWPLTAGFTCFAIAIIGFAMSGTNGNMATAFNAVGGIGFSAPLILLVTLVQLSTPPLFIGIASALTISVRTLGGVVGYAIAEAIYASKTNTQIPEAIIKATVPLGFNPQYLGQLIGFLMSGQGLDAIPGINGRIIGAASAAMKETQAYGYKITWFAFLPGAVLAAIGCACFQNPKDRMNWIVDAPLRTEDVNHAAAPVGSDRDSANEEKVADMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBX9</accession>
    <name>A0A2S5BBX9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBX9"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="283" mass="31555" checksum="67F91AD0009D8E85" modified="2018-07-18" version="1">MPATAPKGSCLVCGTETTKRCSGCGPYTHLYFCSTEHQRLAWPCHRWACGSAAHPFRLPAFSEKELDETMEMLNCKSDNPQVVGLVHAANVKLLGKRTGATDDEKKRVLRALLGHRVVFGTADDKQQSMNQRLSDLRVIRHVWLTTAVSGSDADDPIGFFSLRYHDCTSRVPTRIKDGQWHGASEWHSTFCHLLLVLAPIFARFPTRVKLDAFMSDPNKLVGMMQSFYDLRVAVTHIKEHLRAAVTSQERAFADAVLAAIDDPVNSCFPDLSPLSSERRLSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBY8</accession>
    <name>A0A2S5BBY8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBY8"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="128" mass="13786" checksum="95CF8EFEF50A04EA" modified="2018-07-18" version="1">MHAPKVSTVAHPSTHHGGGPSLNKAGEEGDAILDGVSSKSHKAKDDGAKDSHASKSADSHSKSESKSHSAKSNSHSKDDKKQSDKYEWEDRKLDAEEMRGLYLLGGMLAGGFVLSTLTQPGYMRRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCC2</accession>
    <name>A0A2S5BCC2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCC2"/>
    <dbReference type="OrthoDB" id="2528574at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="518" mass="57902" checksum="029A0A4ED30314F3" modified="2018-07-18" version="1">MSWLWSWWSSPRAPAPAAVAKSGAQELTERQLHALHDEWNRAQNRSRVEADTILAKLVNENNELRDRLTATQSELKDSRTHVRIARKLVFGIFDLEEDFFSSRILHSPNREQAAVEALMLKVAEAAHSGAGSNSGRPWTVVCFFFWNGSREFIDRLLANGLFDSLRDYENFIGRLRRLHPLFQLLTLDIPKEALRQKQADFTLAFGRAASATKLVLGRWALNDRMFEALVSLERPAQHLGDSNVCFVEPLVGTLVSPAVRRLRPRFWSFEGTLRAIPLARRAGDNRMLEINFNKPLWQQNPPLCLDYYLNGKRCYDERCTFSHGYRLQPQVVEALRYEVARTACPLEASGHPCPDGLGCHFAHVCPRDLTCDRKRCRFPQWMHSPRVASPPTTVAAATPAPAVGFPADPLLPSSGAPYPKVPRAPTAHPEGTENPGRVPPVGGTLHEIQPASPFAHPLSVASEHRAPSGQSPRPPELVQLTDAELAQMLRKARAEEKEYERGLREDPFVGSGPAKPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCG2</accession>
    <name>A0A2S5BCG2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCG2"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2596"/>
            <end position="3156"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3389"/>
            <end position="3715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2052"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3182"/>
            <end position="3206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2052"/>
            <end position="2074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="3748" mass="420781" checksum="02ED19826DE47A52" modified="2018-07-18" version="1">MAGPPSTSSAGRRPSQGPKVQPGTFGQGTPLEGQSFETIADKLRDTTIDYKVKTNLATELRDAIDMYQKDLDLGKLFEVLLPCFTEILRNGEPAFRSNSGEHKLRNLLIQILHRLPHVEPLRQHAPDLMSLLLHLLRIEAEDNAALCMKVIIDLHRTYSRPPPPSASTAQSAPGADPSAASAAAAPVVDPTVAQIEASVDEFLEIVAELFKNMGPVVSETFADSSSRHTRSQGNAAEANAQSPSSTGGPGSIGGDSEAGSGSAQPVIHAPAMRSFKLLQDCPASIVFIFQTYRPLVNKAITIFVPLVFDFIQMQAEPQRAKHAMQDPGTSWVGICPEIPKEKRGAFQDMVMAQTKTMSFLAYIHRVSNTALSSYLNVLPQIAVRLMKDCPSEAVAMKRDLIIATRHILQSDLRTAFLSQIDTLLDEHVLTGNSITGHENLRPLAFSMLADLIHHCRADLTLPQLSRVVHTYCANVHDPTLASAIQTMCSKLLLNLIDPIASKEPSEAVKILQRILLAFVSRMEAMAEVRDEWSKWSKAREPLPALVGKVRTREKERIEWTKRQQEKGKGKAIEPAEGDAAMDVDNSAATEGKEVVKADEATTSDAMQVDGSAEASTSGTVKEISTAGEGDDKTVAKKDENKEPAALSLDDVDVERAKPIKKAVVMVDPGPDPIKDARFLFRNLLFGFKTLSLALKRMGGQGPDTELMCRFFDAAVKSMILFDPARDQGREQKEVMEVLTSTLVHTELVIFQEVIENRMGFFFDELIRNHELLVIPQSLLSNESVSQHFVAILFRFLSARLPDLGNSNKENTSVMLRLYKMSFMAVTIFPEKNEPVLLPHLSNLIMNSLKLASQAAEPNSYYLLLRALFRSIGGGRFEILYNEVLPLLQTLLEQLNALLKSADKSRKDLFAELILTVPVRLSVLLPYLSYLMRPLVHALQAGSELVSQGLRTLELCVDNLTQEFLNPLFAPVIDEVMVGLWKLLRPLPFNHQHAHTTMRILGKIGGRNRKGFSPPKLEWKPVGPEALLNINFEGKDATIRIAPIVEVALKIIRRGDVHYRRVAYQFLKYSVAVFLRDGLQVGEPEDTFLQILKGLFDATRVDDFQEEANKYLLDLARLIFALELGKPMPENPMQAKQLLPLSAAFIDGLIENMCTVESPDLSAAAAQTKKIVEALLEFRTPPKTSSPTPSGRPVADAATAVLHQLATRMATQCYDQSWQRKCGAARGMLILISEVGLETRFCIDHEIEFTRALLFALKDMPGEAPSNADMVTDTLLTLVRLCSSDTSDIDKKARRITLNYLVGLLLVEVSCQVASVREAVKRALQTVSEGEGTPITELLRPVKERLLGPIFTKPLRALGFTMQIGHIDAVTYCITLDPPLIEVDEQLVRLLHEALGIADAEDSALLGGKVTYKTMAPLTQLRVVCVQLLSAALANSQLNTPTYNQTRIRALSVYFKLLYSKAPEVVDAAYQSLKQVMLAQGKLPKDLLQTGLKPVLMNLADHKKLSVASLHGLARLLELLTNYFKVEIGQKLVDHFRSLAVPADILRASAKQTSEDGELEVMAAIVNIFRLLPHPAAGQYLEDVIEMVVSVERLLKKLKTSIFTKPLTGFLALHPEKTTAFFFSRLGEERFVPTFRAVLSSEHGKPIREYIAQHSHDLFAPCFDKDGDLGYHATLIIRELIGVEKRWIVDCDSVLPLLITRWVSDVRRTRLKMQGVPHVQQLKEDSVIVEIFIAYLQQEEHIDLLFHLVEAYTYSTSADLTALSRFLNLHVALSEDVELRRRVLDRFLDIYENPAVTQAHKSAALRLLVNPILLIVYSRAERETGLVDAEWIAKVHTKVWQLPHNHPLELGALDEEELRVELCHMTTLLIRQAPSLIESVKKEVIKFGWISIRFDDIDVTQTAYILIASFLAEYESPAKIVAQIYVALLRAHQPEARNLVREALDILAPALPKRMPGSGGGAAQGPSWAILTRRTLIEEGSTIPLLVNIYQLIVRHPDLFFAARDQFFPHMVASLAKLTLNASIASDTRVLTLDVIEVVLKWEKKRIELAKQDEGKMDVDGDSAERSPKRLKTERGASTAPSVASSGAGMTYVPPPSLRDQVVNNLLRFISNSPEPVQRNNLVHRALALLRELIGPSVWDESNVKLSFFQRSFASDVTDETLSQLCNSAEVLNVVSSYKPAEWHVQNIGVLHGIVEKGFSSGEMRLTSSLRPVIERLFDHLPRNVNADSADVPAPVKAYIEWARATIDEGLRQMTNLPAIILLLQAWAKVEPERVDMFVPALIRVFTRYIKEHVASATVVSSVDPNLRLLVSTLDVLRQRVSQLGEQRRWLLSGIVQLVEKSSNIDVCRFILQMVRKWVFDKDEQFPTLKEKAGILSKMISFESRNSEALQKDFLNLILDIYTDASLARSELTFRLEPAFLMGCKVRDPVIRSKFLATFDKSLATGLFSRLHYLLGVQSWETLSETYWIHQALDLLLGAVDTKDPLFTPGASLTVAKNPPAALVTQLEAYNMGELLGAARKLLYADPAATHTVWVSTFKTAWTCLTRIEQRHLTEFMVSLLIKDYHLRSVDRRPNVIQTLLQSAAACTPTLVLPPHVIRYHARTFNSWYTGIELLQETLTDARESDSIRETAMDALSELYAELSEDDLLYGLWRRRAAYNETNAALSWEQIGQWGQAQVLHESAQITARSGIMPYSESELALWEDHWIITAQKLQQWDVLSDMAKNEGNKELLLECAWRLADWNQERPMIENALESMNPVATPRRRVFETYLALLAAYSAKTPEEATAAKKTFAKLCDEGVQLSLRKWYYLPETVTQAHYPLLQTFQQFVELQETQQIFSSLAGTNAANLDTRSAELKSIVGTWRDRLPNLWDDINVWSDLVAWRQHVFAAINKAYLPLVPPPNAPGGQQNASSFAYRGFHETAWIINRFAHVARKHNLNEVCITSLTKIYTLPNIEIQEAFLKLREQAKAHYQNASELASGLEVINNTNLMYFNGPQKAEFFTLKGMFLAKLHLHDEANQTFNLAVSMDMSFPKAWAEWGEYHDRMFKENPSDLNIAANAVSCYLQAAGLYKSAKVRKLLIRILWLLSLDDAAGTIAKAFDNYKGEIPTWYWITFVPQLLLTFTKTDARYVRSILVKIAKTYPQALFFQLRTTRDDLQQAKQRWIAQEKMRQQVIMRAAEAAAAKGEAPPPEPESSNQPLVTPGGTQIPAPIQGQRQPWDWMDDIMSILKTAFPLLALSMEMIVDQMSSRFKPQPDEDIYRLISALLSDALQQYVGRAAQPNDDGLLAPATMGNIARFAESLQPPQTKANFEKDFLTSKPNLREYVQRLQDWRDRYEKTLNNKGKRVNLEASSHWLVEFQYQKFDEIEVPGQYLQHEDNNNNFVRISHFSNRYHVHRGHGVFFRRLTILGQDGSVHQFMIQIPAARTSRREERIMQLFRMLNCTLSNRKESRKRNLQFAVPVVVPLSPSVRIVESDASIATLQEVLEDHCESLGLSKEDPILAYTERIRTMHRQDPPLTRPEILTARQEVFEELSTKMVPDDVLKKYLTKSMGSPNDLWHLRKHMTTSMAAFIFMTYVMSMADRRPQRIHISRATGKMHTSDMVPSIVPGKPELVHGEPVPFRFTPNFQRFIGPHGVEGLLTSSLVAIARALTESEFDLEHRLSIFVREEISTWFTMSKAEPRANLRDYVLNAVDAVVRKAQVMSCKYERERPASAVVPVTQSVLQLIISATSPINLSKAEPTLVPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCJ3</accession>
    <name>A0A2S5BCJ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCJ3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16852" checksum="5C31514A321DFE52" modified="2018-07-18" version="1" fragment="single">MYPMLVPILRGNSLVSFDYFDSVGTWSIHLSDYADFATPAVPLPEEFFTLFPRVRHLRLAYLQLVSLERLAILVKASPDLVTLQLTNALWNIQPDDLALISPQDLSPFEVRVCEILEDLKHLEEVSSFSLPSPTSTAAHALSSLLRRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCM7</accession>
    <name>A0A2S5BCM7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCM7"/>
    <dbReference type="STRING" id="741276.A0A2S5BCM7"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="280" mass="29526" checksum="955672AE82D2D887" modified="2018-07-18" version="1">MASGVFSAGAARLAGKTVLVTGASGGIGAATAIAFARAGASLILTARRQTQLEEVKQAALQANKEGATGKGGRVECLTLDMQDRNAIKGLLDRIPDDLKNVDVLVNNAGLVYGKEHVGEIDEDEIQVMFQTNVLGLISLTQLFVKEFKQRNSGHIINLGSIAGLEPYAGGSIYCATKHAVNAFSGSLLRELVGYNVRVSEIAPGMVETSFSVTRFRGDKAAADKVYEGLKPLVAEDIAEEILWVASRPEHVNVADVLVFPSAQASATINHRGPQGPPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCW6</accession>
    <name>A0A2S5BCW6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCW6"/>
    <dbReference type="STRING" id="741276.A0A2S5BCW6"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="91"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="461" mass="50944" checksum="AB197E9A75A8307B" modified="2018-07-18" version="1">MTVNSAPALCAGATEPPMTPPASPLSRPGHPPLASLTCLASGCVTTGLSCGCSESVASTANGPLATADESQKVVKVVASHGRTGDQIELSYSSTKVVGNGSFGVVFAAKLAPNTLGPDNEGDDEVAIKKVLQDKRFKAKGPSVQNRELQIMRLVRHPNVVNLRAFFYSNGDKPKKDEVYLNLVLEYVPETVYRASRHYAKLKQTMPMAYIKLYMYQLMRSLAYIHSVGICHRDIKPQNLLLNPPTGVLKLCDFGSAKILIEGEPNVSYICSRYYRAPELIFGATNYTTNIDVWSAGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIKPHPFVKVFRPRTPPEAIDLISKLLEYTPSARLTAIEAMCHPFFDELKTPDAKMPTGKDMPPLFDFTREELSCRPDMISQLVPQHAEAALRERGLDVHNFEPIPLEQMRLQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCX2</accession>
    <name>A0A2S5BCX2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCX2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCX2"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59806" checksum="D5E370B7C937124B" modified="2018-07-18" version="1">MGAPPSGSDFAQDTLQRSTGTAHPGSLASIAIMTSQAIQQPPDASLEAHRLVHRFLLNHGYTDSAAAFEREATRANHRFTSAARNPGEAGHDLQDVVDDWVANRLARLKVDDPTATLKDQLDQLELDPDELPREEVQVRTAIRDASNVLSVKRAMVPRREWDSQQLRFVSHDLPCLLTTAVDRTLKVYRSDSFDLVDSYDLPSPALSIAQYPGSKNARLVACATMEGSLSVIDLVSRQVVARVKDHTKYIVRIAFSPTGEYLASLGYDKLLHIYRVVTSKSTSSPSQSAMCGDDEPSDVLAETPQVELQLVHTIHTRTNPEAAVWLPEQPGRAGEQWLVWTAREDNLLHYLKAPSQDQTAQQKWETEEWNLNENGDSFISFSVLSITLHPTLPLLSLQTSTASARILLYPFHSAARLLTLHTTASQSDYFNPRHAWLPSGAAVVVNSEDGIVRLVDLQGKVRLSRGAHGIAAPDEDLASDAAGGQVSPEVRSERARLRREADRGSSVVRDVEVLVPQEDDKGVVSAKGWRIVSCGFDKTVKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD21</accession>
    <name>A0A2S5BD21_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">deoxyhypusine synthase</fullName>
            <ecNumber evidence="7">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD21"/>
    <dbReference type="STRING" id="741276.A0A2S5BD21"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="384" mass="42415" checksum="A7F467780F203455" modified="2018-07-18" version="1">MSSAGPEAAKAAVFVQSEDYQGTRIKGPDFNEPHSLQDLLDSYERIGFQANGLARAIQLIEKMRTWRLSDEPINPDSQTEELDPAVRAETKCSVFLGYTSNLVSSGLREVIRFLVQHNYVSCLVTTAGGIEEDLIKCLGPTFLAPRGEFNQDGAGLRRRGLNRIGNLLVPNDNYCKFEDWVMPILDKMVEEQEGTSTASSAAGGDRVRWSPSKVIDRLGKEINDESSILYWAHKNQIPVFCPALTDGSLGDMMYFHTYKAEIPLSIDIVADIRRLNDLSIKSKKAGMIILGGGVCKHQIANSMLFRNGADYSVYINTGQEFDGSDSGARPDEAVSWGKIRIDGESVKVYADATLVFPLVVAGTWGKAHWDRLAERDKADEAARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD56</accession>
    <name>A0A2S5BD56_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD56"/>
    <dbReference type="STRING" id="741276.A0A2S5BD56"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="59"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="315" mass="34820" checksum="B43894EEBEC2078B" modified="2018-07-18" version="1">MADDPYNAAPVPMTDVRHDMPPSRDDRDSYSAPRDYPPPRNTAPPPPRPSNAPVAEPSNVLGVFGLSIRTGDRDLYEVFSGQGRRVEKALVVYDQRSGRSRGFGFVTMGSIPDAESAIAELNGIDLQGRRIRVDFSATKRPHDPTPGEYRGPRRDDDFGPPRGGPYGGPGGGGDDRWATRGGPSYGGGGYGGGGGRGRYDDPYGGDSYRAPLPSRGGDDHRWSSRDDDRSYRRSSRRADSRSRSRSPAPRRSRSPAPRRSRSRSPAPRRSRGGDDYDRDRSRSRSRSPVRRDRERSRTPVKARGRSRSPTPRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDC8</accession>
    <name>A0A2S5BDC8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2059</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDC8"/>
    <dbReference type="STRING" id="741276.A0A2S5BDC8"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF11">
        <property type="entry name" value="RING_U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="559"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="427"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="685" mass="72566" checksum="DF569CC8105C8E7F" modified="2018-07-18" version="1">MPPASVRRVPNPQAGRLPALTVTALTMLTVGWIAFAFLAPVPDYTDYATQGVAADVQWTGDANDAAAAGIRSGAASSPPSTSYGRASYAQQEGHHVIELTGANDQDKLAFAVQHGESNPRVVKPLPVVPTHDSLRNRLRVSLDETATMIGDFLLGLFGIDDGGDWFGDGDFDYEASQAGLDGSALSTWSESSVYVERTNSLHPSRPSSFGPHILDEPLRGYLFPIEAATSTDSYACTALAVAPAPITPTGPWIALIQRGKCPFSEKVRFAQKHGAEAVVFGDQSEVEGGISGGHGLLTPWSPEGTDDVRIPSTFVSRASYLSLLKTWKDEQDTVKQPPEPPMRDDPTQTSISPRDGAPELVGLEVVLSKDEMLASPFLDLLFVLLFLPSLLTLVTVFIQRLRLARAAQAERAPKDAVARLPVFRWGDHVTPPASTAPSRTSTGTAVPEKASGRPAPTDEERDVGVEGGQPQASTSAAVAPLQDRDEPDEETTLLPHAVSAPNTASSPSLAQRAFARLPFLVQRFLPAFIRPPVPASPANGRSRLNNARPTRRFPSIVECPFCLCDFENGDSVMELPCGHLFHDEEVRGWLEGQKGVCPVCRTSVMNASPPTPPTPSAQSAATATAATAAAPVSPPVGGPAPRSSTRTDPPPPPPRTTSAAIPGANHEQAETAEPAHGSGGRPRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDJ5</accession>
    <name>A0A2S5BDJ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDJ5"/>
    <dbReference type="STRING" id="741276.A0A2S5BDJ5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="76" mass="8590" checksum="DA2108C8EB70E602" modified="2018-07-18" version="1">MYSVWDQFDDLVFHKINASDVCAFQEEYPWLPAQVWGAIWTSISCAGLIAGVLGGVLLFKKDFSEQYLEALSFIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDP6</accession>
    <name>A0A2S5BDP6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDP6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="485" mass="53339" checksum="2282036924BF56FE" modified="2018-07-18" version="1">MSHSGRLRSTVEDRSSRAKMLRAESIDDPEAAEFIREFSAADKEKQEELRAYVNGLVAEAHAIHAARRSAKSEGFESANNDPMLISKEAAAGDSKASGALDGRHADDERDEGSGSDEVEPDEFEPLEDLSGSDSESVIAASDAGSDEQHSSDAISVDTPDGDAAESEAADAVAQARPLACKDVRDKFRKDDRYDCGAPDQRLTLPIDRSPELKIAFERYVHELVRLFESTRHSDDIVDDIHFAWVAREEAEEHLSSARKILSGREEQLVKATDPESGRPATTRRKSESAALVQQARADVAAKQQSFERAQEKVAEATARKRSADHHETANLARYDLAFDELEKAYIAFAETRQSAGPSTREALNSPSAVDVSSSALQLDRTSSRSEIDAELDGRCEPSAAMSRYASDRQAHVRPTRPSCSSKRTFSDEGGREASKRTRGDENHGSGEPDEQVNDAAIKEDERKAPPRKQQFAHRRHVGLLRLQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDR0</accession>
    <name>A0A2S5BDR0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1891</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDR0"/>
    <dbReference type="STRING" id="741276.A0A2S5BDR0"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="68450" checksum="AD290C2DBDCC08FC" modified="2018-07-18" version="1">MSLSSHEDKAQLAADDLEARQDRLDNLHPAASPEVPRAQTSSEDHPPAYHVQPQTGVRKVEIVNRVWGRNSKIALGVGIALASYIYSLDGTTTYQYQAYATSSFSKHSLLGAIATAQAIVLAVTKPFAAKFADVLGRAEAFSLSVAFYVLGYIIIASCKNISAYAAGAVIYYIGYAALQILIQIVIADCSTLRWRGLLSQLVSIWYALRGSLCSEIPELTLCSAFVSSNIAQGVLSTSSWHWGYGMFCILIPATLAPVIGTLFWAQIRAKRLGLSATDYNETNGGTAAAARDTRTIGRKLVSWAIDIDAIGLLLFGAGWACVLLPLTLTNKSTLPWSNYKIIVMLVIGGLTLIGFLAYERFLAKKPLFPFRFFKSYTVVACAIIPLLDFYQYSFISVTKAWSISDQGYFAYTQTLSLTFFAILAGFYQVYFRRTKWLLVAGLLIRLLGVGLMIRSKGAHGTTAELVIVQIIQGAGGGIAAAATQVIAQASVTHQDVAGVTALVLLFAEIGNAIGTAIASAVWRDWMPKELSKHLTGILSETEIDAVYGAITTAVSYRGVNEPAYEGIVAAYTTTMKILLIAATAVAVVPPVLALFVDNVYLSDSQNATEAEDLGGLPEHPRGTVADRDEKRADMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDY0</accession>
    <name>A0A2S5BDY0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDY0"/>
    <dbReference type="STRING" id="741276.A0A2S5BDY0"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="340" mass="37542" checksum="548E30583B3BD8F1" modified="2018-07-18" version="1">MSSQLVLVSGTSGFVGTEVTLQFLQKGFRVRGTVRSQDKADAWEKKHAGEFQKGQLEWSIVEDVAGKGAFDEAIKGVDIVAHTASPFHYNFTDAEKEMLIPALEGTRQILRAAQKESSVKRVVLTSSFAAVLDFDRLQPSTTFSEKDWNPATYDKAKGMGDNKAYVYCASKKIAEEEAWKIAKEPETKWELCTICPPMIFGPPKQVLKSLDSINTSSGAVWGVVDAKEVPETSFPVWTDVRDIAKIHVLGATEEVAKGKRYLSIAGHFDNSQICDVARKSFPDQASRIPEVEPTSGPEHFKTDSSLVEKELGIKWITFAESVKDTLGQIFDLEKELKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE81</accession>
    <name>A0A2S5BE81_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE81"/>
    <dbReference type="STRING" id="741276.A0A2S5BE81"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="217"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="521" mass="57671" checksum="497363EF83A6A42A" modified="2018-07-18" version="1">MLRSLAHRGTRAARSVPSRASSSSAPRPAALASNQPPAAAHAPPPPGPPGAQAVEDKKPQPFILRPLSRRYQLESVEAAPAIDPASGSTTLSFISPASPKQPRTVTVPNLWLRDGSIHPDHVHPSSNQRLFRTSDVPLEGKLVGYGVHELPGHGECLVTEWSAPLRGSKNPTSAKLSVVPTRNLVALLENPQHPLEGDLPAPRTWDRAALNETLVRMPYDRFQSDEAALHETLDALVQDGIVFLTGVPNAEREGHHTDLRQLVERIGSLRRTWYGDLWDVKAEEGSLNIAYTNLDLGLHMDLTHFDNPPRYQFLHSLQNDRVRGGLSYFVDTYALAAHLHATDPSAFATLAEQDVHFEYRNGPHHTRFVRPTFELAPGSNSRLHAVNYSPPFQGPLPLQRLSTASGDGAAGGNVVSDDAHRLAELHDALSQFSALCDDPQSRWRFEHQLAPGECVVFDNRRVLHARTAFEFEQEGEGECGRWLKGAYMDGDELWSKWRVLGRKLLESEQEKLRTKGRTLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEJ0</accession>
    <name>A0A2S5BEJ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import receptor subunit TOM40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEJ0"/>
    <dbReference type="STRING" id="741276.A0A2S5BEJ0"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40095" checksum="DDA62D00BE067F47" modified="2018-07-18" version="1">MAAAPQFAAPFPPKAGLVVDDSYTAYLPSFLRPVGTLLDSLDAARDRLNLPEPGKYEDLGREVKLTHLTNYTFDGARADLAKTLSQVPAFQVTHSFAAGSQGGPMGGINPGTYNFGAVYATSKTFMQGMVDNEGGVTGRFNYGWSPKNTTKMSVQLAASAASPSMFALEHDRVGKDYTLSLKSYNPSPADLTGSYMAAYLQSLTPHFAVGVETLYQRPTPDMEDCSIGYMAKWHDVKKDEGGNPLQNSWIATAQVMSQGIWQATYWKKLGANVDAGVDLVCVPALNPRERKAVATVGAKYDFRMSTFRGQVDSTGKVSALLEQRLSPAFALLIAGEIDQVKSTSKFGIGCSIESQSEEAMAAAMNAAPMAPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEL7</accession>
    <name>A0A2S5BEL7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEL7"/>
    <dbReference type="STRING" id="741276.A0A2S5BEL7"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="54"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="648"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="81818" checksum="FA0118291696AFBB" modified="2018-07-18" version="1">MADSAVDSSEATMQVALLNSASTPQGISASGYSIRRRQLVSLIDQLRAAGASTEIDLPRIAVIGNQSAGKSSLVEAISGIKVPRDAGTVNCRIALRFETDPAGRPIETVRELAFGGTMHDPEQVEVMLRRAQLAILNQASALENLAYFVGLPQEELRPARADTPSDDVVIARSDLSNSPLPMLAQQQAFSTNVICVEVAGPDITDLAFLDLPGIISNADDKRDIELIEDMVRKSISGNTLILLTVTMKDDFQNQKAVLMAKEADPDGKRTIGVLTKADTVQRGEHTPWLELVEVRRHQLAHGFFVCKQPGTEDLAKNLSFQDARAAEVDFFKSEEPWNTLAPHIRRQLGTGHLVAFLSDRLARYISEKLPQIRSDLVTSLNSVHNALKELPPAPSSDPVGELHIRLAALARDLDSLMQGTPGRADLVQAKNREDQRYKADIRATRPVFVPFTASDEEETLRAAWEQQHRSTSGDSVDALRMDLDALQLHIKEHKGREVPLNTPYGAKTSLMVRAMTQWPILSNELLERMRGPVNDSVSALIRRHFESSDAELFGITTMVVSEVVESLFARAAERIEEHLELEGTPFTLNDHYFAKTREDLLSSFREARRPTAAVGKKYIDWDHVDVTDALSALAACGYPGITADQLPRLLGPDKFEEALDAAAQTRMIDTIPRIIDSAVIRPLPASIGDALLKRLVANGDDEVRRLMAEPAVLAEERAELNMRKNRLEEAKRVFASFGRSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEP3</accession>
    <name>A0A2S5BEP3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1618</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEP3"/>
    <dbReference type="STRING" id="741276.A0A2S5BEP3"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="65"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="456" mass="49536" checksum="0C93D3722B3AC0E4" modified="2018-07-18" version="1">MLATRQVIRVSANKQFSPALARSFSAVARPAAVPKAAALRTAFPRAAVLARTLGPVRNYAAEAGGKFERKLPHMNIGHGKTTLTAAITKVLAEKAGKGKVLGYDMIDKAPEEKARGITIATAHVEYETSNRHYAHVDCPGHADYIKNMITGAAQMDGGIIVVSASDGQMPQTREHLLLAKQVGIKKLVVYINKVDQVDDAEMLELVEMEMRDLLSTYGFDGDNTPIVKGSALAALESRDDNIGKESILALMESVDTWLDQPPRDLEKPFLMPVEDVFSIQGRGTVVTGRVERGTIQKGAEIEIVGMGASFKTTLTGIEMFHKELDRGEAGDNMGALLRGVKREQIKRGMVITAPGTVKPVKKFEASCYILTKEEGGRYTPFMNNYRPQLFIRTSDVTVGLTFPPGTESPDEKMVMPGDQIDLVGDLVHEIALEEGSRFTIREGGKTVGTGIVTKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEV9</accession>
    <name>A0A2S5BEV9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1678</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEV9"/>
    <dbReference type="STRING" id="741276.A0A2S5BEV9"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="647"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="714"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="978"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1060"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1108"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1157" mass="124052" checksum="84352C306D0FC937" modified="2018-07-18" version="1">MRAIEAAPPLTPSAASPSFYELLGVEPSASADQVRMAYLKLAKAWHPDRVAPGKRDEAKRRFQDLAEAYMALSDKGRREEYDVALAWEVSSALAPPPLHPLHTSLERTGPAPYTTLDYNEERLARPESPFPGHRVPPGGYPQARLVALSQAVAPSARPDLPDPVQLGASEDLASRIEAIFAGMHDLALGGDLHHLDRSRPRHRGHSPPDHRHSHGNRVYDHAGHGNQGWNGRWPHQGDACKTARKEWTEATTERNGDRVAKAGRHEVKYYEDGTTKWRSSSTTIISHAQRHRAHSPCNLEHGIARPLLTYPTHRPPSPGLPLPSPHYHTHHQHHRHRSHSVPPLALGPAHSSPPHIATRSPGGYIPGPSRHYDAYSPRFIADGGHHAHGRYGHRPGPEYGHSSPLFGDTISGAAEEQELTLRAVVVGLVIGVLLACTNSYFGLQTGWISMMSLQASLLGFAVFKVLPRSGLFDNRPLSIHENIVLQTTAVATGTLPLAAGFVGVIPALGMLSPELDGGAEPLILSFRALLAWSFGVAFFGVFLAVPLRKQVVVREKLVFPSGTATAQVLGVLHGRPLVNSTDGVKDGLRKRRRSDSVASGSARTGERAFMLHREESMGQDDLAALHDDEDHESPEQEVVGRRAWQSLIISFSMSAGYTLLSLAMPVIYAVPVFDIFIRKAAHDWLWWFTPSFSYIGQGIIMGPETVLSMNAGMLCGWAFLSPLATHFGWAPGPVSSSANGARGWILWPALAIMMAESILSVSFVAAQALKPILARTAERAKQGNLFVRAERDAIESDDEDDDADSLDGLRVGRSGARTPTKRVVARADEEPSTRVVLVGAALSCISCVLFVAAVFGEDGIRWWATVLALVLASAFAILGVRALGTTDLNPVSAIGKISQLVFAVVQPGNVVANLVAGGIAEAGAQQAGDLMQDMKTGYLWGSSPKAQFHGQLIGSLASVFVSTGVYCLYRRVYDFPSTAFPVPTAAIWLNLARLVNQGQLPPHTEEAMLFFGTAFVALAALKAVGKAKMAAAKADGAGMMGDGDESARAWRWTRYIPSGIAFAVGFINTPSFSLARLVGGLVSLYYTRTSSRSSRGSSSSGASHLEHFRLVLVASGFVLGEGLASVVGLGLKSADIGGPATCWGCGIGGGGYCGGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEX8</accession>
    <name>A0A2S5BEX8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uridine kinase</fullName>
            <ecNumber evidence="7">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEX8"/>
    <dbReference type="STRING" id="741276.A0A2S5BEX8"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002070">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="9">
        <location>
            <begin position="56"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="318"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="545" mass="60426" checksum="9AAD32CD3CB2DC50" modified="2018-07-18" version="1">MPESVLLSDGASSQRAPPSGPPVQPLVRSLPKNLVMTESGRSPWYGLDGKPSKAYIIGIGGGSASGKTRVAQQVLKSLGVPWVLVVSQDNFYKTLSPEESKAARANNHDFDSPDSFDYDKLVQCVRDMKECRSVHIPNYSFVEHQRTEETTYLYGANVIIVEGIFVLYDKNLRDLLDLSIFVQCDSDLMLARRLRRDLVERGRDASGVLDQYLRFVKPAFDNFIQPTNRFADIIVPGTNNERSVDLIVSHVRRQLSERRRELRGELYKETAPGGASSVPSTPGVEKCEHEGGLFFKVKDQDGEWEQELLPDTVHLLKQTPQIKGIHTLLRSIDTDPENFIFLANRLSTLVIEHALSMLPYRQKLVETPLDLEYVGTELDIPTGHLCGVSILRSGASLEKGLRRVVRDVPVGSVLIQSDAKTGEPLLYQVALPEVLTTSFESAAKSTVLLLDSQIGTGAAALMAVRILLDHGVKEENIVFCCILVSKVGGVWALKRAFPGVRIACSAADSGLEERWEKGDTEDKKIFTILPGLGSFGDRYFRSDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEY1</accession>
    <name>A0A2S5BEY1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEY1"/>
    <dbReference type="STRING" id="741276.A0A2S5BEY1"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="3">
        <location>
            <begin position="36"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="300" mass="32433" checksum="E2D1894AD8537DB1" modified="2018-07-18" version="1">MSPRIRTPLRPWLSRLYSTSPSGPRSLPSPLQRELFRRVAQPVAVITAHIPELAETPAGLGRSRGASRKSSKEPHNHGATLSSLASISLSPPLVSFSLRLPSRLATFLSSEEEPAFSVHLLSTEQESIARAFARQAPLPAPSRPSPPPDLVASRTAQGPIQAALPPFPPRLFAELDERSLGSMTCRVVRQLPLAALDSTAAEPISPEQPRSELFIAQVEDVRLGHSQEGAASLLYWDQRYAGVANPGKGSAAHCIRVTYTATHRHRNDTPAAETVQKPHVNGRPARLGSSGTAGWRRLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEZ1</accession>
    <name>A0A2S5BEZ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FHIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BEZ1"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045668">
        <property type="entry name" value="FHIP_KELAA_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19311">
        <property type="entry name" value="KELAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="7">
        <location>
            <begin position="150"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="6">
        <location>
            <begin position="530"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="8">
        <location>
            <begin position="1401"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1530"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1660"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1539"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1615"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1660"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1716"/>
            <end position="1733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1780" mass="194119" checksum="7B6E149FC360B671" modified="2018-07-18" version="1">MKIGVRTGGIAAITRGVAGTGMTTTKDAADGTRTAATERRQRKAARKAEKLADAALLLPEEARQAAAEVAFYSAQDNPFHDANLGDKFVWGKKREKERKMGLTPEEAAKRDRERAWESQQEIERLNQRRAEREKEAALREQEQMQQMRFAESAQMAAWIDKEDDFHLEQAKKRAEIRVRERRAKPIDYLALNLKWSVPPLGPGDEGYDEKKALEEEEEDDGAGLEVDLEEPYAIFDHLALEDAEELHDDIKMYLSLEKVEAHQDFWRALLIVSSAALEALREERSIGISAYQAQTRANAAVKAEITRLLSGKTHDQLVQLQGQVQAKLASGEVIDVDYWEGLLKELVVQKAKAKLRDMHEVVLNNRLEQLRKKQRDEALRYAQEVKNAIHVPITRDEDDDDDDNEQGDEDMEVEDEDAEADARPGVVSEAWDDKWEPTLHKKIPEECRQCQVVDFAEDRKKLYAARRAVAQARFVVKPRAAPTAGAGEGGAAGASNKDEEIYQAAVGQGFDDEEEFFNMEAEMSRQSYTWEDKYRPRKPRYFNKVHTGYEWNKYNQTHYDSDNPPPKVVQGYKFNIFYPDLIDKTKAPQFKIVKNKENPDICTIVFTAGPPYEDIAFTIVNRPWEHSHKRGFRSSFDRGVLQLHFSFRRNFYRTPRKPSAASEPPSADRLFSQLRRVLADDNANAARDAADEVARLLHDLHDALGQEQQSGAPLGPVLEFILENDALDQFACLVLQPERGPFRSRLLEWYADAIDGLEGSWLEHAAVNKPLIKLIKGCLSTGVTSEEEYHFVVLLCTAAERIRSVSTSDTSFSFSASLATGASSYAVEYDCLLFTALVRYVHREGDIGDAARAGVLALVSLARASPVFATSPVQAAAAPTHAASSPAASTPAGERDLLLVFAEWILESDLAEVVSASIGALYGALPTKLAGRSEAVAPGADRDAALAGSGMVLGGMGALQDEGDAEAAARKREEEEDSLRAQGFGIAGSPEVTGALVVFSRVVDFVQQVVLACSGPRISLEAGRLKGGLTSDPTQRELDLVLGAVASNLVATIRTSFLQGVLYPSILECSEADGSAVAVLSYLDAMFDVLKDGDELEAAIFAFLLAEETAPTQQAAVSTPLRQRLNDLHSHGHRRKRSHGLVLLDKPALRTSTSDDYFTAGGRFSLRDLLQSNIESVDSATVAAALRLLKTILTKHDRWSLALLDVEVDDLATAFPGVTFAALPPVAHSGEHGVEATLGADEEEPFVYASQEPRTPRARTKGTTFPSTPASVLRPLLERGNGQAGSQAAGTDPLEALLSLVGEIDPSYRRMRNAGGGSEISTTGFANYLRDAETELGRDPGFRRGLASLVHLEDEALGEVLDDDEPRRSAISRAVVSKRLSGLDLASTETGRRHHLDPASTFLSTLLGAFSALFEHPPEVNLALTEAIATLALSPYRSLEGWCLPVDLVEPRDHGRDNGGRLFIPAMGSAAEAQNDSLLSILRALASSIEAYRRRIPKFDEYLGERRKGLFFADNLADALGGLSLASDLAEGTPSSRPLAPPIALPIDPSPAPKPSVTSGLVSLFSPRRQPHKRSPSTPNAFMTPTRPGGLGLQRPSQLRRSASDESLAAPLSPTAPSSGRDLTNRSLSYATALVAEERRAAGPASPFAAHYRETGSVQVQPLVVSTPSRRAREQTRARSGLGLEETAEADETDGTSQLGEPDSPSRRLSNLPVEAGAPGPGTASLPSSSPLPTSTAKVSLSMILDNVIVLEEFVKELAAIVYVRRVMGIDPIRVAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF00</accession>
    <name>A0A2S5BF00_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF00"/>
    <dbReference type="STRING" id="741276.A0A2S5BF00"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14812">
        <property type="entry name" value="bZIP_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="390" mass="41492" checksum="B0DDB112DFDC8757" modified="2018-07-18" version="1">MYADSGFPSPAPSSSSLMSGTSDSATSSSHTGRTKRHATEVDYAALEGQAGAEHGLTGGERPSKRRAPRSTAAEKQARKVARMERNRIAAQVSRDKKKQQQELLEARIHQLEDELAHRDGTPAPRAPIELAPVPVPPPTQDPHEVDQLKEENETLKTQLALEKLHSQSLQIRLAALETKFSRLEQLLDKSTLLAHRPSVAGGVATHPERQPETKTHQDTEEDQDSSRLVAREVDSSLQRKLSCPLPSTRALPSRLLSAPTSLPPVVPLDLDYGLALDNGAGAGGLELDLGGGVGGVGGFSTEPAPSAGLDSSPLFGVDDSATGFVAPLFSESDVNQAWLDWSLNVEPTSVPAPTLGAIEPPATDFDLVAFLRDQQQDALPVSFAASTLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF05</accession>
    <name>A0A2S5BF05_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1573</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF05"/>
    <dbReference type="STRING" id="741276.A0A2S5BF05"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="698"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="882"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="909"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="940"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="966"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="990"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1000" mass="111442" checksum="176D2351EA45E4EE" modified="2018-07-18" version="1">MARQHLAMQRHPSTAVQVPRFLSKSSLWRRFSAFCGRHLNFYRIHLLWFTFVPLIASAIFYASNGPSPENKIAYIDCLYMCVSAICVTGLSTVLFVNLTVWQEVILGVSLLCILLWSGEDVSSRSLLAQFLMLIGGISFVSIIVLGIRRQFFKNKFDYLVRHDAEARERVNEVGAAEAAREGREYKAFDSAHGPKRFPYFGSHHHSRKSGAAPTESTRRTESGTVDGDRTLTAGQNRRYERKRDGRLRPDMIRRVDDPVRVNEMSNAGWLGGRPISAEPEAAVMSRRPREASAGSVEAGGDVAPQESALSDAEDDMPAGILQSGGEARSHGVVQIGEQPQIVRHATGRQELAVDRTRTIEFRETNEPDVRRRANRSQPAHEMQFAPARRRPSRSSIQDHELGARTLTRTATIDQTAMESGFGGFPNPLRAAAALAKEKIPLVRNTFGRDASMPRTTTMISTHSRGETTVAGTQYDRSGAVKPVSYISFDALVGRNSRFHALTKAQQEELGGIEYRALTLLIKIVICYWAGLQLFAITMLAPYLTYVNRWSTVIRDVDANPTWFTFFQYISSYSNTGLSLVDASLVPFQQCYFLVFFQGMLILAGNTAYPVLWTMSKLAPKRSQSRETLQFLLDHPRRCFIYLFPSHQTWFLVFLLIVLNSIDWVAFEVLDIGTPQIEAIPVGTRIFDGLFQAVAVRSAGFAIVNIGAVAPALQLLYVIMMYIAVYPIAVSIRSTNVYEEKSMGVYDEDFDEDDDEVESRFRKSPSATGYIGYHARKQLAFDLWWLALAVWLICIIERGAINSGDLPEVNVFSVIFEVVSAYGNVGLSLGNNTNAASLSYTFRTLAKLVVIAVMIRGRHRGLPVAIDRAVLLPAELERHNDDITTRSSLETMEARARARRGSMASVARSMQDEPRLHALERTASRTSWFQDERSQGGADTIRARDIALEEKAPRPTEADASDEKIATDSTASDATSSAGEKQGGPDVEAHCTQNRDQVGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF22</accession>
    <name>A0A2S5BF22_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF22"/>
    <dbReference type="STRING" id="741276.A0A2S5BF22"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="487"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="844" mass="91851" checksum="28D6A15D67806EA0" modified="2018-07-18" version="1">MEGAPLVRQHSRSSSQFASTFGPLSPLTATAPQLPSPDKEPRPERASAQERRRFGSDASLTTRPRSGTTTPSLPPTDPWTPAQSSFPSTSNSLAQFIQTKRRQASAPYFASARSQSLFSPGAGFSLGPGEAAPPADDDSQSRPVSRNRSRASSRRATATGGLTALRTHGLESFADIAQHDGGLVPTPTIEEWRQLGSDLNALAELRIKEEAGREEEQQQKPKPKWKRWPSLQDSWDDDDDDDSSGDQAEDFRLSLSLSTLGRNKRQLPHTPPSAEDEDDSPRPSYKSSFSYSSSGFGSTGGFVSHSNTRSLGQPSPDPDTMAFEKQPASDADKSPAERMLTHASRPSLSRGSLSTATGTLSTPSPPRSSSTESLSDLQHAHAAEEPGRAPKPHLPPDIYRVIAETATPDDFPSSAPTPFDGDPFASSAPAGTSVPPTPYYRAEDNVKLETTKTGGGAVDLDWTKPLGPVDPRTYSAVTGLRDIRSFVCEDEEAGKGAYGSVRRARERGPDGKPIGPELIIKYVIKQRILADCWKKHKILGPIPIEVHVLDHLRRVPYEPRPPLNYITRGGNPKRLKGKPVRRDSAPQLDLWHGGEDGGTVRTGHPSICPLLDYWEDSEFYFLVMPQATSAATSDPTPRRGQDLFDYVDAHPDGLPPADIHNILGQVADALWFLHEHSIVHRDIKDENVAMDPTGLVRLIDFGSAAYVKETRKFDTFSGTLDFAAPEVLKGARYGGKEQDIWALGVLGYVLVCGECPFWSPDEAMRGISPDTRAFAALQAKALAANDGQADSLKTIQAAVDLVMRCLEIEPQDRPTADMVCDHAFLVGSEDGWHGEHGWDCKREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF49</accession>
    <name>A0A2S5BF49_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF49"/>
    <dbReference type="STRING" id="741276.A0A2S5BF49"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="7">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="5">
        <location>
            <begin position="231"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="6">
        <location>
            <begin position="450"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="65477" checksum="EBCB6FCDC0D8319B" modified="2018-07-18" version="1">MPSAEPAAASDQEPVEVFTTSNILLQALVDAGIKRAFVNLGSDHPALLEAFASRKKYGLDSLEIVTCPNEMVGLSAAQGYAQVCGLPAAVIVHVDCGTQALAGAVHNASTARIPVFIYAGASPYTENGELAGSRNEFIHWLQNAVDQPQIVRQYMRHVGEIRSGTNAPQVIHRALQFANSEPRGPVYVWAQREATEEHMDASKVPDVRANEIWSPIELNPLNKKAVRLIGDALLKAKAPLIVTSYLGRNLAAVEQLQSLVDLLAIPVLQTALSNVNLPFTHPSHTGLQFSGPAPIVEESDVILIIDSDVPWLPMKTKPKKDAIIFHLDVDPLKERMAFATYPAVLRAKVDAALALEQLVEYVSTSPAFAESEQKIATRLESLVAKKRESIKHLRSLEVAAEGDILTPNLVVATYRKLIEAQQLRSLVCNEAISNYVPVWEHLEPTEAGAALSSGASSLGWALGAAIGSQMAATDYSAHKKDIVTVFVGDGSFIFGVPSASYWMARRYETPFLCVVFNNGGWKSPKLSMLGVHPTGLGAAGPSAELNVTFGPEDSLNPDYGGIAAAAGGAWSRKVKKASEIEEAMAEAVRVVREEKRCAVLDCWLPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF83</accession>
    <name>A0A2S5BF83_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4385 domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF83"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025494">
        <property type="entry name" value="DUF4385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14328">
        <property type="entry name" value="DUF4385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30196" checksum="CBC3D19A8354FEE5" modified="2018-07-18" version="1">MPSPRKRSPSPAVAMSNDAVRHFLAPRAVRMSYRIGRSEQGVLTFEPYKGHLLPMWRFKTPDIARDSSARIEQEFLKFEAAGDFVGCDMARKFLQMGMTRSTRYANRAGGRKYDATSGDLLPKSTDHPGRADKLESAGIFREAWERVKNREAYADLRRAWEREKKEWDKAGRPGVEEEEELKEPKAEAEDQEDRVAEQRKGGKDGAVEVEADVTTGSGQTQRVRSSTRRVKEEHDDEDEPAEVEEAQKPKRKRRKVDSKVKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFI0</accession>
    <name>A0A2S5BFI0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_1431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFI0"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="114" mass="12007" checksum="65B99802A4BAB501" modified="2018-07-18" version="1">MSSEPRPVQAPPDMRRTATDSEVSAPAPKATVLDAMRTIDPVSDLQRLPNMPCARYSLLFGIVAGVSVGALRFLFARTGRRGTLRGGAEGPWSQVGVAANWAVGAWGVASLGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFM2</accession>
    <name>A0A2S5BFM2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFM2"/>
    <dbReference type="STRING" id="741276.A0A2S5BFM2"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="446" mass="47175" checksum="16BC404B8EDFAA94" modified="2018-07-18" version="1">MTNPGAASGHVHTISGGSGFNLDMSFEDARASKCSSCMVKQDMSNYWTPALYFAHANGSFTLVEQVGLIVYYLPRSNPKDPGSVKAFPDGFRMLAGNPYKRSFDGSDMAKAIGVNCLGGSREPTRQPDFPPNNCPNGMRLEVMFPSCWDGKNVDSKNHQSHVAYPVGGETGPCPSGFPVRIETLFYEIMWSVDPWKDRWKEAKNTSQPFVLSTGDPTGYSLHGDFLNGWDGDVLQKAIDECTADSGVIEECKVFEFYDYEDGKNKCFQTPAIDESVTGTLAALPGCNPISAGPEDVTVCAEKSPPKLFDHITVFGGLSGGNHSHDVATRSSQPSSPDSTSAKSSASAETFVQASSADDTSAGRATAADASTSSAAGPDPSAGSMMPSTAVWASIGAVALIGLLVAVYLCARRGPAPAAPPDSEKQALRSSSDEARSGSDSETSLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFN3</accession>
    <name>A0A2S5BFN3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFN3"/>
    <dbReference type="STRING" id="741276.A0A2S5BFN3"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="4">
        <location>
            <begin position="743"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="854" mass="92144" checksum="98230A910A656AE3" modified="2018-07-18" version="1">MSFEDARASKCTSCQVKQDLSNYWTPALYFAHANGSFTLVDQGGLLIYYLPHRNAADIGPVQAFPDGFRMLAGNPYKRSFDGSEMAKAIGINCIGGTKKPTKSHEFPTENCPDALRMEIMFPSCWDGKSLDSANHQTHVAWPSGGEQGPCPKTHPVRIESLFYEVWWTTAPWKDRWEEAKNSSQPFVLSTGDPTGYSLHGDFLNGWDRKVLQHAIDQCTTESGVIEECKVFDLYDYDDPKSQCLQSPAIDETTTGTLDALPGCNPINYGPDDVTVCREKSPPSLRKEIVISGALAGGDHSLKVATATATPSQGDVGRSGAAPAGDAVTSIVSTQQGSSTRASASDRPQAYLNDETSAASAVLNNGSNTSPASQAESASSGISSSPWFWAATAAAVVFLTAFAAVMAKRRGATPSSANSLRKDTDAMIRLRIAPSWPVSYGRPGARRSLSTFPPSAASSSSLPSTPPAVIGSAPELHRHLLIHTPHPTSTWPSHIESTSHLARNLSKRWQENSKVAKLGFNFTDGGVGQPAQPWDPSWTKFDEPPVESQPEQYSATIYPDFVDVPSLSIAEWSAFEQTLDNLPPVGSPLPSTSAAGNRPERTHIFVCTHRTRDCRCGDLGEPLYEALLGEIRRRKLGGELTAAEAGASGVHIARVAHIGGHKYAGNVLVYRSDGLGDWYGLLRAEDAPKLLDYATSASSLPWYSRWRGRLGLSSDQVKAAYASRPAAEAEGKLDEPRQALGDSVELVFRTHEGEERRVNGYEGESLMETARRHDLPSILATCGGHCECATCHVLIPPAASAGGDAPLPEMTDEEDEQLEFAIGATDDSRLACQLPVTKELGEWVKKGGKIQLPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFN9</accession>
    <name>A0A2S5BFN9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFN9"/>
    <dbReference type="OrthoDB" id="2529700at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015566439" evidence="2">
        <location>
            <begin position="23"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="525" mass="53078" checksum="505EFD973740DA32" modified="2018-07-18" version="1">MRFDYTLCLVVAYAAAAIQAAASPGGGSLDALLDRIANGHKQEADMASSAPIAEAPASTGLPSTSTKMVRRSRNQAAAEQAKRWVWATGIIQDGATDAPPIGQNVNQLGAVPTTVTTPAVVLPSPSYLPAAAVAQYLNASAVAANASTTTGSSTTAARTATPAPRRPLAGVKMFGQPKADHRRWIWATSVIQDGATGVPPPGTNANLLSNGAPATTPEAILVSPTFPAAAENPAATTSTEPSSAPVAIDVAAASTSDPEPLVSPAQTTSTATPTSAGVPVSTSPAMHWWNPTDLFKQIEAGFEELLHGSSSPTAAPVAALESPNEKRWIWATSVIQDGATGVPPPGQNANLLSGLTMPADTPTVSLNSPTFAPVPSSMTPPAALKAAVISASSSIPTTSAAPATTTTSVAQRMAYAQRVAAARAAALAAEEAKASSQSASSAASPARLSYAQQVAAAQAQHNAAVKPAVLAQAAPGAAAITPRQLLAEHENALRASASSANAAAKQTAAGQVYRHKKRMERARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFV0</accession>
    <name>A0A2S5BFV0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1267</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFV0"/>
    <dbReference type="STRING" id="741276.A0A2S5BFV0"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="337"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="848" mass="87942" checksum="BFC9555A0F15048E" modified="2018-07-18" version="1">MQHDLTSIQAFLNLNSAADSPGMAATANDPLVVQPDDQDSQGLSFTDLFRDYLASDVAKLPPTSSANNADLFASLAPFSSVAGSSGITSPSSHSTFDPATCMPSHMPGSPFSPESDDHSTSNGRSPVSLAELDFSTAPVLSGSADDFAIDPSVFDPPATSLGFDDSDALFSLPELAPLPVSASAATAVLPALSVSSAVLPPLPALPVQPVASTSVIASAAPAARPKRNVKHSVIREATEEAEQDEESYSSDASSVAPTSTNAKRGTTRTRRASKKVRSESPSVAGTGDEDGPSARKLARTSVVPLASSTLHHTAANEHLPPVPMWADKPDPKEYAKLSSKEKRQMRNKISARNFRHRRKEYITTLEEEISTRDTLISELQDEVGVIRAENTGLKSEVATLREQWQNLLDKLSNMTTPPTPSAAGTAVAGLGTNPSRAVAAAASVVTPAAQVVKQEEGAEAIMPEAAPTRRIGTRSTSGIQVPNLSKDVAPRRGAAGNWGTFGFGASNSFMSVHTTLVPDVNLVNLADGLHGKPSLATASPFSGQSFNPALNALSQHQLAEMPSATAHLRGANPSDTRSGDAPRPNATFEDFFASANSYVLRPDALDQNRAALYGKLANNAAGLLTAQRQVGEMPGQAPPQQPQQSAADKAYLPIPTGFRPAFFRSPKASSSSSSTTNELLAFQSPSAAAAAAAAAMSPVPVASHQDALEMRERATMAQVAQLANQTLVQRMASSFWDAFVGPSPAGGPGSGAAAKSLDSDKVKAVLTGQARLQVVPVNAAGSPALHPTPLPAVPAATSGGNGLDALERQMGALSVGGVSAGGGSRSESPERCSFADVGRRWVMGEKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFZ0</accession>
    <name>A0A2S5BFZ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFZ0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="152" mass="16887" checksum="E62C8388B161EDE5" modified="2018-07-18" version="1">MSRQHQAGSVEVINRRPQTRTWHDLFDDLILSQDLPQAVTSWTTEIRRTLSNESQASLGAAITQIDALMTTAQARNDLRTYDAWTNVYNLLQEALVNLSQRVQTSQKPSKPHTRKGPTNSLGNGGSALEAKEGNLRRALLYGRLSSAGEAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGG0</accession>
    <name>A0A2S5BGG0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGG0"/>
    <dbReference type="STRING" id="741276.A0A2S5BGG0"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1194" mass="131710" checksum="16338E74B34B1209" modified="2018-07-18" version="1">MDPYGAQYDDQPPYERAMYAGADLSAGFDPLAGAVWVSDPPPQQFRLPQAQHRDAYSYDHDMYRQPQYAQMYPPSLPPTPAHSFQSSQHQAHSQAKPLEYRPYEMLPLSQQQQQQQQYLPPTPALTTTRYPEGLDGSQPYADPNKRRRVGEDDFATVATAAGVGMPGSSAGRGPLVQNVHPAEDYFRLPVASSPPRSHRAFQASETGHPIGASKVHAELAAQAQAITHRRSSGPVPADSWPTLDRQVAAQVATRRPSGARAVDGQSFAPSSAPGSTFVATSTPPHIPPSIATTAARPAQLFHPNTSAPAPAPFVVDAASVSGPGSAGPSHGAQRSRPPAERKTSSDGSQHRPAEPSPTLSTLATEGQTQISRSEKSCKACRIRKVRCSRTWPVCTRCTEKELDCHYGNLIPIDLVKGMHPDSRVAELEARIKMLEHEILMRDDPPRAARGSSAHTRTSSTSMFSSPMPPVNPALRASPSAPHRPSPLRTNSSESDPRATPPTLLLLTSAPPREDFSRTAYGVFVSAFWRALTEPGDPTGTRRRHVDAVVAGVHERAGRLSAARRARHALGTSQEDYQPVDARSGLGLSEAACSPRPGQRVSAKTSSEEDLFEEMARTDATRVSELVDLDIEELAQNRDWARMAIWAVLDAHWATCSSNVPTIRPFHVPVRQARMYTQIDELSPSARCIGLAFCAVGVRSTPYVGLLGLAGGPTLGRDGQAVMEGVEKEDEHLGVKRELVARSLRDAMIELYGRLEIAYGEATKDALEASLILALVQMWNEIKPRYSRSLIRNAVAQYKELFDSAAALASEQAVKDERTDLLMMYALPLLHIDSTTAAYLRAAPILTDADLDTYLAPFKIPLFHRFDAKNGPGEMDLRDQMRSWIDVDAVGDANHVQHIMGSMVIYRWLSACLRWCAQMSCPQARRVPLPPKALEALFEHLSVIHGTIQLVQYHLTHTDGAIHPDCLAPSPDGDTADHIHLRWLTRLDRETDDATWLVFSIVSERLVREEAEDQETDFHHFLKTEDDRLDVGWLQACESRVRKGFKLAAFYFNFFTMSPDPHQSHHLACSLELIPNWTFLATQRYMSSGTSPPSAPHYSGLRSKADELTETELDWIERGLELARKYHPVAERRLVEIRSYRLAEKKRMELLAAEGLSVPISRASPVASPRLGEKSALSFQMAMKRALHQTVPSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGN9</accession>
    <name>A0A2S5BGN9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGN9"/>
    <dbReference type="OrthoDB" id="2534923at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="788" mass="82970" checksum="9146AC6281749EA1" modified="2018-07-18" version="1">MAVAIPTKPRSGASPASITIPATPAERNLLSAASAWIPPQTASDYLRNPARGGARAPERSITAGDLASWRGEHPTDPLRPPAGTDMSDKATLKSYRPPQHPASRVLHSIPPRAPSRSSRANILSYTLHLATSSRLSSYSSEAGSRQLLQLAELERDTKDSFEIDEAWFDAEQKTQGLWKLGANLLRSSRQGGSLPPSVLRRVELAGLAEEALLSPAADRAVTKIDSESVQASAQVEELVALKPLTAPDPTTLYHTTSASTTGLDSESSSGRPRVCSVAQSLIDLKFGGQADPSEATSPVLEDEKPLSTSPLDALASTSGASGSASAGPTTATPHMDYRIVLSQSMRTRARSIFASSPLPSLPASYCRRHRVRSCAVCQALVTAASERESNHAAMRRKNIPGAGLRVGDLQVQMVATIGGGSGAGAKKPLAQLVPEFLKLSAALLRDVKDAANRNATPEGKTLAGGEDALHEALLADLVRTEDKGVAAAAAASSTTTAKGKGVAADQTGKASVSSSGSITPVDVEIQVTAAWYDLLTGLLVQACLEGYLVDGWTGTEGVETLFGLGCGVWEGRGWSAAVPLSAPSAQPAASVPRSEASRVSRRTAGTASDSSDEDDEDDAIDEATLVQRRKDQEATLLVEAGRVLFGARDVAQGDYERNMRDKTQEFLNVPSGKSLHQHLDNLNMQNPLSQFEDDLVDFLEATMHFLGKPALAKYDPRASGGTAPARSSASSTAGSTASGEPDPYALLKWFAPSTFGRISTLNQPRPSTARQASPSAHDERSRKRARAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH63</accession>
    <name>A0A2S5BH63_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH63"/>
    <dbReference type="STRING" id="741276.A0A2S5BH63"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="195" mass="19627" checksum="03BB6DA043BD5D89" modified="2018-07-18" version="1">MSLPSSPVTPGAAAPSPVQTAGSGRPPPPPPPPAPLGLAAPAMQARKSLPGMNGLPAKSPARPSPLPPLSSPAHPVPQYSHAQKSPRPPIPQPSAAAASASPINVDALNSDRPESDSENSDDEAPPTASAPIPQKMPRQGIPTAMEMRRSMTGGSAAAQKVPRKAMGPTPRKSVAKAMADMGSSEEDASGVSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHA0</accession>
    <name>A0A2S5BHA0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHA0"/>
    <dbReference type="STRING" id="741276.A0A2S5BHA0"/>
    <dbReference type="OrthoDB" id="2504792at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="537"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="690" mass="73494" checksum="711BF4CAAFEC3F7D" modified="2018-07-18" version="1">MDRRVKQEDAPPVSNASPSGITPTASPLPTSSDYNDFLLRSTAPPSDSGWKYNVMKFATVGDRVIDPADESNFLRPVKLNRKDPRTVRRLTDEDRERHNKRALERAAKAAGIDPATAMDVDAKPGDVKGEDEGENADGAEKEELDLDLVGKGVDGNSTVQRRGPRGQFKKKFQRVYVASEEARRLKREEWQPWVLEDDEGRERWVGRLEGGAGEIGANAKKGGESAGGAASDQGRIAPATSTGNGSAPLEGWRPAAEASATGGGGSAYVAFVFGDNGDEFKVVPINRWYRFNQGPKYLTLAEEEAEAEYARQQKSKEPERWTMRRRAAPAAPSAPASASGSGSATPRAGPSHNAGGASAAALRSRMLDRSAVGTKPDPDDGDLDLDDLGRPRIRTVISSTSGGAGGGSSRGRRGPRKRAGQDQDVDEFDYEEDFQDDEEGIAKIDDLADEDETRELEERIRREMRAAERPDEIPDQPAEDKDDQLTGTGKEIKKLVRKADKSGLYDSDDDDNPYASSDAESDGAASTTSVDPERSGSRPSTPRSGSPSGAYRSGSVSRGPSRAGSPSSGAAYLAKRATSPAPSTSSSSKRKRDRASTTDGAASDSDADGSKRRKAGGKSPSPAPSGGLLAQGDIVAYLKTRPNQTSTTKEVLTHFRKAIKGDPRNKAKIGGLLRAAANLVDGNLVLKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHI2</accession>
    <name>A0A2S5BHI2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHI2"/>
    <dbReference type="STRING" id="741276.A0A2S5BHI2"/>
    <dbReference type="OrthoDB" id="2526971at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20849" checksum="B3F9C788DB108DF9" modified="2018-07-18" version="1">MGFKDDGCLAVYGQGGYARLALETLKAMGVRERLVLVATSDKWDSDKYSIKREDVLFLGRCDVREELRKRGGAEGVICVDMPKEHIEPVMDGMRFASTMVVLNPRENDQLQVPLANIIAKCISMRGSPPMCRRDMENAFKMAEQHNMRMPVKAYAFDQDNLRQAWRSLENRDCFDAPVVKVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHM4</accession>
    <name>A0A2S5BHM4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_0449</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHM4"/>
    <dbReference type="STRING" id="741276.A0A2S5BHM4"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="135"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="518"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY76254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="631" mass="69344" checksum="EAE4EC41950FF651" modified="2018-07-18" version="1">MTAAEEPTAKRQKLNEEKKQQLPFHPSLLQPDIVDRLRQLHDHSQPYKHAVIDKLFDPDFLKRARKEITEQLSFREKETDIYKINQTGDLTNLSGLPAAELALLPTLLELRDALYGPDFRAFLQKVTGCGPLSGSKTDMSCAEYSEGCYLLNHDDVIGTRRISFILYLVLDEPAWQPEWGGALELYPVLEADEKNPDRPNVPVAKPSTCIPPAFNQMVFFEVQPGHSFHSVEEVVVHGDGQKGGVGARVSLSGWFHKPVEGEEGYEGSEGFQAKSSLQQLYATSLSAPTRYEEQLPLPLPTLPSSADLDYLRPLLNPAYLTSKVIDLLRAQFVEQSHLVLADFLAPSIANELEGLIRERDAEMEKDRRGVTVNGQTTNNIPPHTAGEDERNGWAVVGPPHLQRYLALSPSSSASTPAADRLSTLLREIHALFTSSAFAALLASLTSLLPTAYTTAVRRFRPGLDYSLARGESASEPDAQAKLDVGLGLTPKCEKESDREVWEGGEAGGWDVWLANEEGGDEATYGGGGGRGSAKEAAENGTADAPETQAQEEAEGEEEEEEEDGPLLALEPEWNRLHLVLRDPGVLSFVKYLSARAPASRWDVVGEWEVQGIEEEKAEDDDGDNQEEAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHP3</accession>
    <name>A0A2S5BHP3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHP3"/>
    <dbReference type="STRING" id="741276.A0A2S5BHP3"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="108"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="824" mass="94703" checksum="300C0368CCCA5261" modified="2018-07-18" version="1">MSGRAQYSRQAAGRVSYADLSDSEGSSAGESEEEQKVKKRSKRREKGRKGKRAQRAEEHDPSGDEASDEADDDEPGDDQPRKKRTMRKTKSKGKGKAKQSKAKKQAPLEIFKRLPLELLCEVFSLLGPNSLLALSKVNKQSHDLLMAKGSESIWTAARRRLKMPDVEGLTEPQYAELIFGKKCQNCYGDKVGKIYHDFHIRRNLCKKCRRLKIIRIKNFATDEPVLHERLHPFALECAMKTPHPGTEAWGTWQDRWDTSHKNWVFLDELWRMDTWLRDFDDQDEDSDIAAERESEQAPKPKQARTARRSERTSGRLAGGRLSYKDVSESEDEPSLWVSRRAKRWKEGREDTLKARRKAAKELWDAFKLADSYLEEEARLVSQLARAKEAQAGQQQYNPDREHAIINRFVKDYPQYQDAFDDPAWDTLWQDRSDPRIRSYHASQRALNVLARGEPLAEEGVSDPPSSQWPAIETKLRTLASKAIAQAETYDSAKKRSKAQLSLFARYDALKQSLSDGAQPYMPLFVDFLLLPSVKDLWCTSGTITDQRWQNSLEAIREELDEYRVDLCLRARNAILDATTDRGSRGGADDDSDTEKFDDAFFQRATSFVCCAFPGCPRKQDPPSYRWDWLKRRHVVDNEEQRAAKDTRIDWIGPLAEVLRHQHKHHNHKQALTAQQEKVPETPERICLPLEVACGMISILELHDLDETRAEKKHLMRANESTSGYKWVNSKQTRYRFQSRPRYYHSQSAWSTLLAHIKLEGENLAKSGLYLDPPNIAFLTRADRKKVIEMTEDELDSEDQDGSGAEDYYDDDEGDGAEQDMDEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHV2</accession>
    <name>A0A2S5BHV2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHV2"/>
    <dbReference type="OrthoDB" id="2522477at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="468" mass="51878" checksum="9BD301508A5EC02B" modified="2018-07-18" version="1">MSRAAHARIVPLHSAPRTVAMTDKTSLLSLPDELLRAIVAGIDTPREQLHKVARVCRRLRSLAEEYLYESITLTSRYEQYELLLDAFQRRPRLRSFVKAPLMPISKISATIVTTLLQFPACTELSLMDFSQMTLDEIIGSSYLSRRVPKIQRLIIKADITKTYHETLPPSAWWCVLAAWPRLRDLELDIKGFWLASPGDGLGLSALRRLRLSAAMLPPHDAVFAETCPILDELSIGPIGTNSFTHHILSSGPSGLLCLAHPGKPVAIEQYIARYPQLKSIHIGPGFDPGLLLPLLAASQIEEMTFDRGSPAADDFLAGLLVGPQRMFNLRRVEVNHVIALARSGLYQKLVHDQSFILSGEIHTKAQAFRAEYRPQWPPGCTRAGLSRAVDLAEAAGVSLSGTAVSCINWDAEFDEQFERFLVMCALANDSLEALVAYYGEECAGDILIRHRPALAHLIVDAVRRRHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI75</accession>
    <name>A0A2S5BI75_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="1">2.4.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI75"/>
    <dbReference type="STRING" id="741276.A0A2S5BI75"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="576" mass="64691" checksum="1F4DB33FB5B5940E" modified="2018-07-18" version="1">MVGSHSRSTRLERNHSISSDVSMHVSKLANNGGQLIVVANRLPVSVTADPNAEGGYRFSVSSGGLASALSGCKKRMDFVWIGWPGFDVPEIDREFITKKLQTEFSCIPVYLSAEVAERYYNGFSNSILWPFFHYHPGEIQFDETDWLAYRQANLLFAEAIQKEVHSGDIVWVQDYHLCLVPVYLRDLLGRDPSSMGENGQKDVDAMFEGLTLGPTAASKPDSTSPAGINGTHGNDYVGDVQIGFFLHTPFPSSEVFRTLPVRREILLGILNCDLIGFHTYDYARHFLSSCSRLLNLKCTPNKIELVGRHATVGTFPIGIEPSQFDEALEQEQVQQRIAALRRRYEGVKLIVGVDRLDYIKGVPQKLHAMEVFLDEHPEWIGKVVLVQVAVPSRQDVEEYQNLRAMVNELVGRINGRFGTVDWMPIHFMHRSVPFTELTALYTVSDACLITSTRDGMNLVAYEYIACQQETHGVLILSEFAGAAHSLNGSLIVNPWNTAETGEAIHRALTMPKDERRDNHDKLYRYVSQYTAAHWGTEFVAELQRDRAERRAITESEDRDAQAARLRRQGAQLTGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIQ6</accession>
    <name>A0A2S5BIQ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIQ6"/>
    <dbReference type="STRING" id="741276.A0A2S5BIQ6"/>
    <dbReference type="OrthoDB" id="2521676at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="48"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="293" mass="31612" checksum="E317F6A5DFC4E3C1" modified="2018-07-18" version="1">MASDVPPAPATEPGQAPPASWRPPSLPFVPAALPPLPPIPDATIAVRARTHKGSVTQADGNKRDSRHAELASNEILEWKGDAALHWLISTHLSAVLPTATSGELSDLRSRLTSNRTFSHLAWHYGLTSALFTRKNQLSDNSTAEEQQRTAANALEAHIGGLIDAHQGDVRPVSDYLRQLLLPAVFPAFLHIKRSLENASNPDASGPPNKRPRLETGDAVLDAENRTSSGRRAVTRFRHHQWIDEFTENRRWTATLEIGGQVVGVGAAGKIAAARDVALEAYLDKISNATSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIR5</accession>
    <name>A0A2S5BIR5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIR5"/>
    <dbReference type="STRING" id="741276.A0A2S5BIR5"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="592"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="698" mass="75621" checksum="47AF1193B66D9449" modified="2018-07-18" version="1">MPTPQPPAGPSSRPLDLRAFQLPPLPAFDSPIASVANGNGPVIPTELPKIRASLLRSRNIALERAQTCQTNRTILAERVALERSKPPRDSGKAKEAERKRKREEDAAAEKAAAAAAAKLPAKQPAAPKATPKGIKREPDVATKSQPPAYSSKGKERAIDPPAKARGGEGARSGSGDADGDTPMGDVSTAPSSAGTPAPAPVPAKAPIPIRSQATPSVDTDDDMKPPHLPRHHDKKKRRRDQLPESDASGTEDDQPVLQRLRAHDSAMASASPSPRVARAHLQSDAAPATASNARELIEEKLKEERFSKHSIPVKPPAPGTASAFYVPSTPIIPPKPPANPPAPTPKRQSEVTGDFSNAKPGQQIAHSTLQNWVDAYLRPFGEDDLAVLAAKPEDLTPYIIPPLGKHYLERWEEEDLDPSQRHPNTSFHSPLEPPVLPRLKPEALTEDALAGENVFLGPLSERLMAALAVGEDGLVAVDDEDDDMVSAEDTTAPPRLPMDAVDFEERVKRELRYIGVLPEEEIDWAAREDDEVSSALRACQRLLHQQTAMNEARKGILMSLVKDRMAYQDYETARDAQERVIEQGWQKRLRTDVKKKKKGKERDRRAGAPASAADAGKDEDPSKAPVSAELLDAVARRDRLVSTFKPFFEEEAPGHFFGLPEQSVFEGLEAEILGDDLSEPDDPAPALEAKSIWAEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIW1</accession>
    <name>A0A2S5BIW1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase</fullName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0303</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIW1"/>
    <dbReference type="STRING" id="741276.A0A2S5BIW1"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="666"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="790"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="371"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="428"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="592"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1034"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="468"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="855"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="883"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="883"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="947"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="954"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="981"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1018"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1018"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY76711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1090" mass="117939" checksum="73D6CF2AE02DC2F1" modified="2018-07-18" version="1">MLRNDELVQSPPALPVASSLARRAPSHPLLQLVLLTPAIDKVARIEHAILTSAPAQTLLRYRLASERAVVALVGLASLGAVVRWRRQWRAIVYALAVGDVVKRTVDLLVNLGETGEVSRKQRRQSQQDRERDNDDARQETQHVLSFWLLVALLSLAESFRTTPRHPLVVSPSASVSARLAATLRRVRHAYLQFLRRYILPTLLRTRWAAQRFVSTYPSFDPAPVLAKLPTVPGHYYLRLPFTTPRARPRPAASFPQPSAHASDRPPRGTGPMPLAWAWFLASSSSTTTPASSSNTTAAEIRWTLLKLIVLLMGQRTDALGARNVLWTWGIEPLVAATSRLRGLSDSSPFAEDGDEQDKWVVKLVRESRRKRSPRIAPVTKAADVPIRIVDPSHEADDADETGDESRQIDELSGVSPYAWTPRLARVVRPASAPGSSPALFDQPRPRSPSSTSATPRRPLSRSHDHHASVTPSSRSSSTGSSTHSQSRSYSSANRSNSASPSPYQLQSPPFLPTPIRNASGGNHANAAPKGGTSRSTPAGVTYRFASANHPLLGPRSSSSASSGGSATATALTQAALNSLRLRSGDLVHNHREDSFAEEEEEDDDDDDDGLLTPGEEEAEEGQRKTSPATRLAAAAMVPRTLESKLSGTSRTERPTPSGPGARLCTGGCSKPAGPLECPKCQGLGVAGSFFCGQLCFARNYPAHHKKLHVTSTRSSYVFPPGTKDGFDGKYRYTGKLRAVMPLEEVPKRVVPDHIPKPDYATEANGVSFGEQVAFINERQGRTCSPEEIVKMRKVCKLGREVLDIAASHIKPGITTLELDRIVHEECVKRDAYPSPLGYHKFPRSVCTSVNEVICHGIPDARPLENGDIINLDVSLFHDGYHSDLNATYPVGDAVPQENLDLIACSRKCLDEAIRACRPGTPFQDLGNIIEDVATKAGFTTNKTFVGHGIHTLFHPPGPNVPHYAGNKQPGVMKVGHTFTIEPMICAGREKDIHWPDSASAQPLWTAATVDGKASAQFEETLLITETGVEVLTAAPGWSLPPSDGSPNASSSTSSSKKKKKRKTAAQKAAAEEEAPTSGGFAAEGSNPTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIW4</accession>
    <name>A0A2S5BIW4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 8"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIW4"/>
    <dbReference type="STRING" id="741276.A0A2S5BIW4"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="446" mass="48500" checksum="CC4D73E4F439AEB6" modified="2018-07-18" version="1">MARLRVDATSPVDWLYTAEGGANLVLSYAGDAVPDLQRHALRLRKRKRIAGPQGAIPDQVDVEFGDKVVRPLLGPELCLEAQVVALSSEWLRSVAGSLAARNVRPLKRVEEDDVDVAAGKGVLVEDLISGRGCLSVEIKPKWGFLPSRDHLSPETADVKSAYCRTCMHRALKRAPRITTAKRVGAEPALAVDREEFCPLDLYSRDPARTSRALQQLYASWTSSDGGINNLRFFLDGKLVKPSELPPQFEEKMTSSSEFDGDPASGFASRFTPILLASPVLPRLAALQASLDPLDIEGLAARVRDELGLDLYRPDLAEDEVASTLGGQPTTQEWQAWLERASAPAPPNEQDAPLRDLVLAYLLSATFKDCSIFIRVDSPPFPANIATTLSADDPSAIAGAEIKVIDLDPKPIARMGKYARMDREIVEHWRDSVLAGGAPSRCCGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ49</accession>
    <name>A0A2S5BJ49_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ49"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ49"/>
    <dbReference type="OrthoDB" id="49511at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="222"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="902"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1226" mass="131692" checksum="0D47245F4E5E0BA1" modified="2018-07-18" version="1">MAGLFARPQGEEQRSRQSSATQTLFLQLKAICVPLLEVTKGPTVASTLQQATQLLVQLQAKLEQAKADDFSAALANYAFFPLAALLRPPLDGRTRGDAVLEATMNALAALVVKWRAVGMDARVRQELWIMTTLTLGGPLDPNKPVDTKGKGKAVEMTDEARLAMVRVLVALLRPFGDKVANDADDDDPLGERLDWSKVDANDPSTFSNGVPQADADPLPPTPILFHTLTTLLGLAAEPTSLLPLQLSSLEALRILISQYLAQPVDAAGAGAGATVGPSPLLATALPGTASTLSRIATSRPKKALYDQSATPDRPQASKVVASALETLSLVIVETVGDAATGPLRSMRDGRLDGSVAVVASLEEFVLDSKHGDPAPDEHEASEEPVPPVAEPTPTAQGPTVPTADWLRYTVSSLELLFVSLSPVAAHESPLVRAALVDLLDSVLRQCRATLAGTSEQLVEALLVLSADEWTDLVALPARAALGRALDGARDTTEGRTEATEAREMVLRIVRRRFAALPGSLRRRDEVGAQRCAKVVRVAFELLVDSSAEIRTSFGGIFKDFDKSSWSLLSAIELERVSTGGPRGSGGMALAWITGSGVNDGTPEDSAYPPVRLRRVTEEATVASLQALWQALGHAAAVTESLEAVVQHLLGFPLGPRRADGIAVSALSALDDVMTGARMASSTKSGRKTARTVVKTVIALLDELRSRDEPGGEPAETGDAQVALSSGEEQPIEHRIGVLDIPSLEAYAPVATRQTRDEDRASHDLSLVSWSLRLLATCAVTLGSAFQRHLMEALYHVLEHSSPTSHPFVAAHARQALNLISAATAYASPQNLVLANVDYVVNSVSQRLSVSHLDPQAPLVLVEMIRLVGSPIVPMVQDLVDDVFEALDDYHGYDEITVGLWAVLDALLKVMEEDLPSGDQQTGKLTLAPESAQESWSSLEAWLADRTVTGPEDAPDAALDPDDTNPQRPFAEADQRDMAEEPAEQPTDQVTPPSRTQVVTAQILSKALYFLSHESAFLRARVLSLIASAVPLLTRPSLDAADPTANRASDLMPVIHRAWPYVLNRLSDSEPYVIVEAAGLVESLSRHVGEYMSRRIVDDVWPRFKELLDRMAADSQTTAISSGDPHSTAHRIQKSVLRTLQQSSARVPIKEEMLWDVAMTTRHFLGCSAHPDLQQLAAQLFRNLRRLNDDIIWLILAGSAAADKSLPRFLRMDALVGSSVVDGLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ98</accession>
    <name>A0A2S5BJ98_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ98"/>
    <dbReference type="OrthoDB" id="2529379at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1265" mass="134151" checksum="EEE473C31E35A687" modified="2018-07-18" version="1">MAACMPPGIYGRRILLDFASVALRYLRPPILFSRGEAQTAAAAGRALCATAAERQLYMHSPALQVPATDSEPLRPAETRFQIGDERGVRTGSRGQSPRIIIIRSTEHFGSQRVSELLAVMVPSSGLSVLTKALHAATAPAPRSSETSTTESAAAGAAPRPIMTSSASTSSSLSHTASEFGRHLKRALHDEWSRSPSDSRPPLRQSTSSQASYATAGGSSSADHSSVTAPRRPPPPPPPPPVLPSEHEAAPIQSGFAPPSGPPPGPASLFQQQEKPGFARRASTGLTGKSAEEQEAEQVEQAMRDSLRDEQPRAGQMNGDEADLKRALALSEAEERQRRDDDAARERADFARALAASRRSPTPTSSLQGYDRPTPTNSRPHSPAGLADLLPAFSDRDSAPSGYMPEKSLHHPQGRPALPPGAGAAWDDEMREMEMLALAIRISQEEEEERKRIEESQLGEALRRSETDATIASDSSATSTLAPRIEPSNPGVSSPTSSSDESTALPAAPRSRRSSWIQPPLASSMARQSSASSFDEAGTATAHEPVPPTRPPRPFLLPPAKSPEVEASPAGSALSNEPAHVPSLRPRVAIPLRAPPPKPRRAAPLPPGAAGPTANSPVSSPRLAPFPRFNASGADERWRRDNDGSPQEMPNLTPSSSIRGHGPPFDRDTSGGQPAMGAEAVSLSGALLDRRASQASSLSYTTAPSELHGTSTEDGDDVPLSPLSIRNPDLRAATPSDDSRSSTLSSSTDSMSPRPDYQHDPAWNGLEQSFVPAGAMGMSSYAGRSMSAISELTEPISIAAATEDGASVRGQPSEGSLSRADSFPSTVSIDSEGQDSLGRSPTFAQDRAESGTQQHEDVTDTPRPQAAPFPPRGDSVSIPLEPGSMTMPPDGEASGHSPTIRPMRDSQANLGVPLAEHGDGLRCGYPAECARDLDHVCPADGLSALNSIPETIELASDLPPNHTSWAIEAHSWVALVRALMWYGDTVLCAALEDLSQSPSSRCAATATLEFRSDDEGILVMRLVLTLLPPKDPASHEAVHRELRVQKTPHKSYKGKGKMRAVPAPASTAFLLPDVVHLPARLSSLAIQLYSLRHLASIARATQPSQPLSTKVPSHAEGYAALRELADAIAILAQAAQSRRTTTASTPAGSRSGDDYPQEAATDTGDGPDQNQRLVDRLRSRLRGLKRNRSERPADGESDDLQAVGEHTPRTPNRLVKPPPTGTPGAVHRNRSSSRGRAEEPSAPASRLQVQSVQGRNGDDMRYMPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZ40</accession>
    <name>A0A2S5AZ40_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_7112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000179">
        <property type="protein sequence ID" value="POY69888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZ40"/>
    <dbReference type="STRING" id="741276.A0A2S5AZ40"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY69888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="176" mass="19115" checksum="2BD28B80622E883F" modified="2018-07-18" version="1">MDYKPRHAQPVTLAQLRQLEPELLTNEIARLENSVQHLEASNVELKQWAGMTTGAETAESHDEVDEETRREFAEAAHENEETIASQRERLSMIRLVLEEKIGVDATNPHYELPSHGPSSGSASEGVAQPGDGLRSTQSAASEHAPLNSQARATSNLSQTPAENGSVEASADDGMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZE3</accession>
    <name>A0A2S5AZE3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_7092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000169">
        <property type="protein sequence ID" value="POY69912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZE3"/>
    <dbReference type="STRING" id="741276.A0A2S5AZE3"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="1">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="283"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY69912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57839" checksum="B7EA8AAA429F98B0" modified="2018-07-18" version="1">MTGDTEAIDTLQELFPQRSRTDLERYLAASQQNLERAFQAIDRGLLDDARPKKRARTRRGSNGLAARIGKRDGVTTDAGVLVLNDSDDEVQLSGPAAVFPGELDRTRSAPAKPVRSAYELLKPAERPTQPEPPVATHVNLPPLTLRTSDMVAKHTKGLVTLVENALPQELASRLYVKMVKESLGEGEGDKPWQPNKWYLVDREVTSPHTSCFYRSLPEQITAQSGYDAAGFDESATYWYNGAKRTARPFTSDQEEARLLVREFVRVLLEGRERHPLEYEGEWDPNVAVANCYRGSKESVGFHSDVLQYLGPFPTIASLTLGCTRPFRLRPFIPSGSGATEAVPPPEIRTLDIVLPHNSLLIMHAGCQERYKHAVPPVNGMDVFRLPRTSLEVSDCFSEEEKEVLLARKWNERINMTFRHYRPDFAPRTLTSPPGYVGTPRCACGVPCTLRPDGRGRVKASLSARSDARPRDDPAGQLFFWVCNAGASNEGKTCGHFKLLDMEKEGRGAWFRPSEPEPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZG9</accession>
    <name>A0A2S5AZG9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_7074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5AZG9"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="643"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="893"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1203"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1451"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1643"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1691"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1509"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1654"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1698"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1766"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1851"/>
            <end position="1861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY69942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1895" mass="206065" checksum="7768DF5EA88FB068" modified="2018-07-18" version="1">MADANSAPGHSAAESVHRILSAFRSDGDEQAYLCQLEEGGKKVKRTLGELQQSAPRLLTAFEAAQTTSSSAMQPTAAGPSAVAGAAGPAQSTSVPGRAAVRDPAATTGGGAGKNADRQGRKAAQRRSKKDDSESDDYDRGSSPELDDSADETVEPSSEGSDSGSGDDADGDSDEYDDDAASSGRQRRSGKGKKPAKHATRRSGREKAQAPKRYDFGSDGAYSPTASDADSTANSTSRASRAARRGRSGSSAGPHEVDGESSDELSIQAHPRASTSKMAIDGDGTAEEDASVAEVEGGEDAGGHDAPHVQHVRPQDLNRGSCAKCGLEPGDVLLARIAERRSRKKPGRRRKRDELEEDTDAEEDRVEKYGSWVECSVCCVSYHFGCLPAAQKRELVDRLKAEHLIQHRPEGESELPVLPDLTDSRAGSGRSSKATSPVPKGVPIRPKDELALDKTFKLAKCPACKKMGGRRCFVCGLSGKRVTEGEVQMVRVDRARAATSEHANPPSTAAAAAAENAGLAADGDTSMSAPTESAVTAGPVGTQPSEPVQPSPTKAGGNLPAVTADELTPGLMFRCSNCKRPVHYGCLDHDEPDWSFEEHCTSYQEWSICHDCYNYNVPLDVILAWAEVDPLPVDTADDAEPDDEVVEKVVGETRYDERTKRTIVMPSVKNPQAPAKYLVKWQDMSYRHLAWVPHAFLAAKYPAKLGNFLTRGSTVTFDAPKDDDPEDAEPDDDKKDKLGEAPLPDANAEERVPRAWRTVDRVLNVWYKHPNPKKSEEVVEYSSFKKKLPENQDDSIPLVAQCYVKWCDLAYKEATIDAPPAEGEDGYAEYVAAYKAFLTASQPHMVVPRLSTAQMDMLDSPRSEKTFRPTKDQPSYLTGGKLMDFQMEGVNFLRSRWWQRKGCILADEMGLGKTCQVLSFLSILNHDDGARPFLVVVPNSLVGNWMREFARWAPTMRVVPYNGDAESRRIVEDYEMFDLNGSLKTHVVLATYEALQGNGAVFRRVPRWDCLVVDEGQRLKGGKASQLYSVINTLRIAHRVILSGTPLNNNLRELFNLLAFINPKDYPDVDAVTARFADLTPELVEEVRVLLKPYFLRRTKDLVLNLPPLLEVVVPVTMTPLQRGVYRGVLERNASAIHAIARKAGNGAGSTRGKPKKSNFTNILMELRKTLCHPYLVNDELEPRNVTTQQAHQNLTEACAKFVLLARMLPKLKAAGHRVLIFSQFKLTLNVLERFLKGLDLKYLRLDGDTPQIERQRDVDRYNAPDSEFFAYLLSTRAGGVGLNITSADVVIIYDQDFNPQMDIQAISRAHRIGQTRPVRVFKLLVKGTCEEKILNAGQKKRGLEHLIIQRIDAVDESEDMESMLQFGATAVFDDDSAEKNAIRYSDKDIDDLLAKTAKPVEKKEDAASTFATAQIWVRDGGELSEFNADEAQEDAQPENLHDFWSKVVDQQEAERAQKAAQAMSMDRGKRRRAQVNYKLDVGSPEKQKLGDGDAFQDFSSGEEYRDKDDADSEYDPQEPMDVDALGDGTEAGKPPPLARLDDGTQRPHNAADIAAAQAAAMSAQHRRPARHDPDAERILRARIDAMKIRDIRLAAETINAENVQKMLYRAQIVTTRSERVQWLRQATRLLLEARHQLSQATPAIAGASGTAHQSSSASAMARRASADAPPNGGHRSAAPVTYTAFAPAGMSAPDLSRRSASSSGSGSAVRADGRDGATAMGGSRMAAAVEADRVRQVPHASSAYGDRPISSMPGRPSAEPMQRVASGKSGKSSSSDVSERRLGTTSSADRHSHARTAESSGSARPASAYRQSSLNFARQAPAKLESGSASPVVPQKRLASDAEPPTNGATASSGSSRAGSRSVRDPSQPMNPADVKRLRTTDAAVLVISDSDATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZU3</accession>
    <name>A0A2S5AZU3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_6957</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="PJQD01000152">
        <property type="protein sequence ID" value="POY70047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZU3"/>
    <dbReference type="STRING" id="741276.A0A2S5AZU3"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="16">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY70047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="180" mass="19985" checksum="C6E8C4CCE0E8ACCB" modified="2018-07-18" version="1" fragment="single">MFREELAQLKRLGIRHSLTQALNFALVLSTALMMWKGLAVVCNTESPVVVVLTESMEPAIQRGDLLFLTMPRSTPLRDGDITVYKVPGAPIPIVHRVIEAHNEPDGADQWILTKGDNNPVDDVGLYRGLKYLKRSHITGKVQAYVPYVGYGTILLNDYPKLKYALLAGSSPPPFSLPFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZW0</accession>
    <name>A0A2S5AZW0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_7073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZW0"/>
    <dbReference type="STRING" id="741276.A0A2S5AZW0"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF281">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY69941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="846" mass="90922" checksum="30AE647E1BAC06C8" modified="2018-07-18" version="1">MAGNHNARKLQVRPPTPPGLDSRPHRSRLRHLRSRLSATYSASAPVSDADEPAEVEGAVRRPRLRHRFSHSLTSLVSPRSDSDQDASGNEGGGQLARWRARSKAKLAQAFLPPSGFASSPPCAAQEATSPALLDAIMPTANSSIVRSASRNRSHSAPLLVTRATELVLPMSESHPMNVLAAPLATRPARPLRDPTETPIASPYYTCPSSPWLDQLQQQPEDDPFAAALAAETVPTDPQARPSVDVFSALPYELQLAVFRSLLEVCEGDWVRAIDAGQWTSDAARHRWSDGRAGGRRELVKIGRVSRLWRQLSMDSQLWPSVPAATLLGSNSLRRDGIDTLLRFAGAFATALDARGLGSWLDWKALGTLVDVAAVHGRGSTRLVSIDLTGCTALTATALSTLLSHSPLLRTLLVPGVRCVNDGHMRVLGSGCAELSVLDASRCACLPASSLLHLPYPPPQSSSASQDRECVQPRRGLRSLKASGLSGMNDFIVSTLLERHANLHTLDVSFSRLQDDSMKALVSVPSSENVAAVPNREPSQAGTASSRRRFPRLKHLVLSGCTALTSVGLGHLEGALPELEILEVARLGARARTDGLARLIASCPRLRKVDLEDDCEIGDDVLRALLPNPSSADASRLEHLNVSGCTALTDEALGRLVAGCTRLRALEADGTAMSDRTARTFINLAKDRAAAAQATASSRKQSDPLIDERYPAFLSILDNRTTGRRLSRDMGVGHRPRHGRRGHWTTVVPGYHDPGLTETDATATPATSLRECDQDRVVVRSFHSSLAVDVADAMRAARAVEEDGTSVAVSRSIQPRLRSLSDSEIFRRSGGAAHYHNDSASMGCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0I0</accession>
    <name>A0A2S5B0I0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000131">
        <property type="protein sequence ID" value="POY70290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0I0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="119" mass="12318" checksum="1D002BDF0CABDCCD" modified="2018-07-18" version="1" fragment="single">YTEFDHDPTPAIIAASRATLDSKPPKRRSVLEMLQSPFNNLLPTPSVDGSGKKATGAKKTKTMGTTSRNGPNGIVISAPIRPPSEVDHGLGSKFSGGVGGSTMAAGPAPPPPIYHRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B151</accession>
    <name>A0A2S5B151_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B151"/>
    <dbReference type="STRING" id="741276.A0A2S5B151"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="749"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="822"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="940"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="494"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1090"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="263"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="387"/>
            <end position="399"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <begin position="403"/>
            <end position="414"/>
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    </feature>
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        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="768"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="822"/>
            <end position="837"/>
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        <location>
            <begin position="839"/>
            <end position="855"/>
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    </feature>
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        <location>
            <begin position="945"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1118" mass="117006" checksum="E710F1E132B4D093" modified="2018-07-18" version="1">MDQSLVHADRASDASLLEQSTVTDSSPSVEGQSTTQTPVDQPTDDNDHDGHAASAGVPDSTTDTLLAITDSGRADQSLHLDQALKDTSINHAAHSDATTATDDDLSLLTEQEMLPPPVPLVQPVDAHDLTSASVDESALNDKEVEQTVQTNGAATDPTDGPGAEPFAAEPQLHSSSPATAAPTRQGNPTPPSRDSVTTTVDTTSKPDQPAVGSAATGRKPLRPSTGPAPSRGPLRPSTAGPSRAGPIGSRTAGGPTRPGAARRPLGSGPASSSSLSSTTGSAATRRPLPGGAISASSSSSSAPLRRPSSATGTAPAPPGSARLRSSLASSSSAGSMIGSRPQGGIVSTAKPARGTMASSTMGGLTRPIGSGGPNATASRVGSGPRGAAATTTTTVPTAPRGNATGSRLSTTTAAAGTRPVAVGAGASRGPPLSLAAAGVTTGGRPGSSLSSSRPGSSAAAAAANNAPGAGVRARTVSGLTTATAATMAGGSRQLSPAMEKIRALEKELDEVKGRLEDKEKEVESGQEAAEGFKVKVDKLEKQVSTLTSELETLRAQRKDEVHAVRTRITDLETDLQRKEAELAERRSAHDDEVVRLRGELEKLEAELAEAKRTHEADLASTRSSHESALADLRTVHTSELDALRASHSEALAGAASEADSALAAQEAEHARALEELKQHHTIALREARAAVTEEHEGRFADLQTEHATALDELKALHAADVERARSEAGGDADALRASHASELEALQGQHAAALEEARKEGLQGSTEQAEREKDEALTRLRDEHAREMEELRRSQQTEAGARQEEHEERVKALNERLSTLEEEHAAELSKVREEHARSLASTQETASSDLSTSNAAELEQLRRESEMTLSQLRASHAAELDALRLSLETGIASAEATKHAEVQGLTRELEQARAEIDETKNSIVELQASARKAEADLEEARRALDAAQTAAASSSSRSGELDGPSLEEFERRLADAQTQLEDANKALAETQASAQTEFESMRKMHEVELASAEEDHQNSTRQRQEANAQAMQELQAKLIANGEIRERLETELEAAQVKIRQMSESLAGAVMNVDLAALHTAHNHKLGETENAARAELAEKQEMIDDLRRQLAAARATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B165</accession>
    <name>A0A2S5B165_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B165"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="459"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="459" mass="49705" checksum="DA8EE73A45730CEE" modified="2018-07-18" version="1">MQAPTGGRAPSRSGYRPRQSNYLRISATAVLQMIMYLEPAHVEWMNDSVLERMLIALRDRIPRKLEQEGLASKTKGREKTQVDVFRGSESAGSARVPSAACPREVLIPRYLPPARRARTADYQMAFFFRKSSDKHVVLLKHKHFYAPPKTEAEATGSPDFGGARKRRRRVVVAGTGPRDSSAAPGPSAAAGPAQGTRRATSQPPLFGSGQPTLGLGLEKDDDVIVVKDEPVDEEGLPPVPGPSSEREDGAPSPQKKRNLGEVKLEDDGDDEGYDKDVKPTLKVTYQSYKIFGRTLVVIVEPYPPLDPKDLAQPLTGLSTEVRQLSASVAPDSYRRRTAARSSISVTPAPALQDRPDGGLFRREETEDAASLRGSVTPSLAPDNDADDDDGDGGEEEDAQKRLLRAKSTLLANDWPEQGLTGNSDDELPSLDELIERSKGQGNVPGAALEVEGDQPDGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1A5</accession>
    <name>A0A2S5B1A5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clu domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B1A5"/>
    <dbReference type="OrthoDB" id="771227at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="3">
        <location>
            <begin position="437"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1467"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1469"/>
            <end position="1481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1513" mass="164245" checksum="FEA0E3691743E1DC" modified="2018-07-18" version="1">MAQPTDPEVAAQVDGQLEQDIADDVAIAASVEVTLLVPTQSFVDVGTSQAKTTSDGFIELPLPVALTDAVHDLRAVLTDAPEGFWLGAFSLAPCYADEIASNDKADGAAEQQYGEWQKLSPPPRKTLAPGEVDAESWTLNEHGVLGDFSDLTAVFGGDASQWEGKKRGLKVVLTPFSSATMHQHLLKLRDILFSSLPPFASTQSVYDPTSFALGAGSTLYASVSAVAETGKPAGAASTEEGSEEKASSGKGKKAKAAKKAQEPVEEASPSEPSPVLTGAHAFTGFKIEDLEKEVLADQIANASPAGPPQLCIKSLGVSPWSPPPHPRRMRGELIYVTVQTLESEQFTITGATNGFWISKITNTTFDPSPRAVLPKNVRTGAYHSLFELLADISSSFSKNLAPLIARSSRTDLTQSELVASLAITHTQPPAPYLVKPPTHVADPFRTQAAYLLTSSTTAEQLPVARDWNDEFGQFYDLPRATVNDRLLRERLICRTQADFVAAATRGAMSIARGDVPPLNPNEPSAAHTFIHNNLLYTKAEDAAGMYIQSGGDEASRYSAGKDLRGVEILERLDIEGLSMMQTVLVDYLGQRWIVQSLIPGLFKTAREGEAEVALASEGALEVYPAGDEKAQKAAEAAKDADKPFPSAGTLNKDDYPPTAGFRIVYGAASPEKPEEKVRASAYFHEKLAKQVAKQMRFAEHSVKTLDGKTTQLYTSSDMHGIAAPDGRSYFIDCFRMQCVDVEFLEKDVGEANAGEAYPHRLVLLRPELLDAYRESKLDAWLKERVQETRDKVAKEQQSVEAELKDAASTDASTSEQADSTNKAAEPTTSVINADDFELDFNPDAFVERRQADSGENFVVYDADAVSSKNVRLASQYLREVVLRDFLLEAVASPLLSTDGFLISRTLHRKGINMRYLGHLVALIDSEGEKLEGPKAISKEETAFILNLLRANLVHEMVIRAAKHIVNHHLRAAGPYDAAGIVSHLFNCLLGSDFNEAPVPETADLPSDVSRAWTSVTPSSIRADVRREVAARFRFSLPDTWFSESMLKKKVLRELSLRIGVQLAARKYNFGTRSDTDTSTAETQQSRPQVNGSAHSSDVEPTVSSSSKKGKKGKKAKTAQAEAAQPRGEPTTFDAIDVLNVAPVIKATQHRSALVEDMFYQGQRAIHENQAEVGEALVNDALHLCEQIFGAVHPEAAEKYHALGIMWHNIAQRILKTLRTHDAAEQALRELPEADRAKYEQQVSNMLLPEPEAARADVEAYMNQAVRLVRQSIVISERTYGIDSADAITQYADLGLLEQQAGNVSVALQLTRHAMNLYVATYGPKHPQLVTLLTNAAVMVQSRDGVVAALPLQEEARRLAELVYGPDSVAVGQAENVLGQTHVMLQDITAAHKHIQLARDILAKHLGEESQEVREASQFINLVEQTFARDAQEQAAREARLQARVSQNGAAPGRSNALSRVALGKRSVNGSAAPAGAPSAAPQRTHGEKADLSVDELVNFIQGPSSRKARKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1C0</accession>
    <name>A0A2S5B1C0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1C0"/>
    <dbReference type="STRING" id="741276.A0A2S5B1C0"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000599">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="179"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="469"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="628" mass="67638" checksum="B4982B574608401A" modified="2018-07-18" version="1">MAAPSLQYATRSQKQLSIVSGPPAWNTLATFQQPGTKIYRYSEDGRLFASVSNSTIEVVDAQTGNVVSQIPAKGILDMYLSPLGSQVQTWERQVKPEEGQPPHLNLRVFDVRSGAEIIAFSQKSIENWHLQYTADESKAVRCVTNEVHVYNPRDWSAGIIDKVRLEGVTSISLSPGQNPNVALFVAEKKGAPASVKIHGLGTLALASGSKTFYKADKVQMKWNKSGTNLLFLTQTDVDKTGKSYYGESNLYLMNSAGQFDCRVTLDKEGGIHDFTWSPNDREFAVTYGYMPAKTVIFDARVKVINDFGLNPRNFLSYNPQGRLLCVAGFGNLAGQVDVYDRQTLKKVASFDAPNTVHCEWSPDGRYLMCATLSPRLRVDNGIKVHHFTGVLVHYEKSEELYQASWRPTNPGWYPMSGPLEPAPAASISVASAPVAKPAAAAGAYRPPHARGTVTSNIYKREDEGGAAYTGSNGADLFPHSRTANGAGNGGFSQRGARRAIPGAPPGAAPNAEDPLANRRKKKGGNKKGQQQDGGASPADSAPGSGAATPLAPPIPMVTEPIAPAAAEPDAGNALSPEDKKRRAIVKKLTAIDQLKVKKASGEKLELTQHKKLESEAELRKELAALGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1C3</accession>
    <name>A0A2S5B1C3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6368</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1C3"/>
    <dbReference type="STRING" id="741276.A0A2S5B1C3"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="170"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="435" mass="48976" checksum="138C0DB5020315C6" modified="2018-07-18" version="1">MISAFFILNLKGEVLISRLFRPDLKRSISDIFRIHVVASSTPPTSPLITLSNTTFFHVRHGGLWLVGVCKHNANAALVYEFMYRFINLGRSYFGKLDEESVKNNFVLIYELLDEILDFGYPQNSESDTLKMYITTEGVKSEQAVREEASKITIQATGAISWRRNDVKYRKNEAFVDVIETVNLSMNSKGTVLRADVDGQIMMRAYLSGTPECKFGLNDKLVLDKTGQPAKAKTPTGGLEDSAVELDDCQFHQCVKLGKFDSDRTISFIPPDGEFELMRYRSTSNINLPFRVQPIVEEIGKSRVEYTVHVKSMFPAKLSANNVVIKIPTPLNAASVDCKVGLGKAKYVPAENMIVWKIPRFQGGSDTTFTAFASLSSTTMQKPWSRPPISIDFQVLMFTASGLLVRFLKVFEKSNYQSVKWVRYLTKANGSYLIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1E8</accession>
    <name>A0A2S5B1E8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1E8"/>
    <dbReference type="STRING" id="741276.A0A2S5B1E8"/>
    <dbReference type="OrthoDB" id="10586453at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="362" mass="40880" checksum="54B6F36FABC1B5AA" modified="2018-07-18" version="1">MTHWIAFPRPPTTAEVYAAREQGYKRGGWSDRTYPVARPRPQVNNAPTPRPRDTRAPAESNVRAAISGGSTVGDEEEPDFGRAYRSFVEEGIPEADRHLFQHAHDLARLRERDARAGDTTEESSARDEEELDPDLHFQSDLAPPPAQKRRRSSQPPLAAVDFTLDFSRDSDELSRAPQTAGPSFLDHSRFTGTRTDDSYEQTFRSQADHIGGAPEFPFRKRQLVPLNELHAVRDPKQLVSVLAAVWDNQERDTSRGRLCEWSLVDSSGHSCPFARWLDDYSADAEQVRLGDVVFLGSVSVKSWMDKPQLNFRKNTTQIKICWRTRVIDAEDAAYRFHRDWASEIPEAAAVIQEAEAAEAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1J2</accession>
    <name>A0A2S5B1J2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1J2"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="12"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="587" mass="63729" checksum="24DC60BC200303A6" modified="2018-07-18" version="1">MASIAASAARTTPVHLVTVLHGLWGAPQHVNYIVESVTRQAAAATRTGKDRGHTPATKVVVLAPSTNAESFAHTYDGIDVCADRVLAEIDAECKRITTEDPSARIAKFSIVGYSLGGLIARFVLGLLDSRQPSFFDQVEPVHFATFASPAIGIPHYETFWSGTFRFLGSRLLSRTGNQLYERDRFLPERFTENGNTPEQDRCKTGLGRYLPRGKEKAEPLLKIMADPRYSFHQALLKFKHVDVFANTVNDRTVPFPTGAFEAHDPFALARAQAKKAADARGDDPDAVPDIREGGLEVHLVRSTPLVESYGPPEKPFVPSPEALAKNKKRRFRLRLPLLLRPTTYPFSRPVSLLVICFLPIALPLSVGFLITRFALQGRESRKRIATARKEKGEGREGMLMRVGVRIGEIAEQVGGDNPEYAADLETSETEEGSYESERDQGTGGDGNGNGNGEASERRVVGTRTPASAASTPRTSSAASSARSSSPLIPVSSASPAPSAGAPATTRGPAPTAATLAEARKLRTDPALSPSQLFQLEHLNAIPQLRKHYVYLPHARNAHGAIVRRDPAIAMHREGKKVVDAWVSGFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1L3</accession>
    <name>A0A2S5B1L3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000104">
        <property type="protein sequence ID" value="POY70684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1L3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015707752" evidence="2">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="72" mass="7841" checksum="28A04A4143B858CE" modified="2018-07-18" version="1">MCPALVIGNTLTALSAFLQFLSTLSRSDFFQPLPAGPKDHGGKRGQRREERASEMHAAGFALKILLDALSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Q1</accession>
    <name>A0A2S5B1Q1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-pyruvoyltetrahydropterin synthase</fullName>
            <ecNumber evidence="4">4.2.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.12" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000098">
        <property type="protein sequence ID" value="POY70709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Q1"/>
    <dbReference type="STRING" id="741276.A0A2S5B1Q1"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="UniPathway" id="UPA00849">
        <property type="reaction ID" value="UER00819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="127" mass="14126" checksum="985E8F461F16A8F7" modified="2018-07-18" version="1">MAVHGHTYEFQVKSKGPVSRKTGKIADGAIIEDALHMGIHEVLNRKNLDTDVSFFINRPSTLENICLFAWRNVGVIMAHTGTQVYEVSVEADRCPRADGTSIERTRVSFSGPSFFYSSRGYTVLTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1X9</accession>
    <name>A0A2S5B1X9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000102">
        <property type="protein sequence ID" value="POY70691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1X9"/>
    <dbReference type="STRING" id="741276.A0A2S5B1X9"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="539"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="952"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="952"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="987" mass="107036" checksum="B89CFD5AFB7FEDAB" modified="2018-07-18" version="1">MQPSSHHQMQPQSGQQQQQPQRYVPDGYAGPYSTYPAAPATDYAGHGVRSSGPYPSQHLESPQAPPHHRLQQQHHQYPSTGALPPDPRHHHPQQQQQQQLPPPPSPLQTDRLRAGVTRSHSRTPSSSQEPDEHSYDYDAANASSGNGAASENGGGGGRHANGGSGSNKRARTSVGLVVGPPLKRGNACNICRKRKLERIAEKHRKLEERIQSLEAELEAYRAQGSPSTSSQPNTAFPSLNVPHTLPDPAGPDGALFYSAEGSANSQGDSFPQYSTQQLPVESPFIFPDATRPDVANGSRGLVHQSPQDSVAYPLPPLSLPTSAATLYASASSSSAPSNGVAGAAHLQSFPFAMNPTPQLSDLVNPTSANGASGRGGDNKAGIVSAAAAATGQDFTNAHPYQQYGQDGTIVNVFGTDLPPLQLMLDLAEIYFATLHLHLPFLHRRRFLYTLHNSASLAAAPSQSLVFSVLAIAAAYHDSAVIRSQGVLWYSKAREKVDLAISANVDPMSGSRVATLTVEMVQALCLLALIEMGQSDHQRAFLSLGQAVRIAAMLGLTRMDEDRVADRTGQMNEKRLRPPALHPLPDDPVLLEECRRTMCAVYVLDRFEAATVGWPAAISEMDVRVLLPCADHDFENGLCEADGRNNPLWWPADGAGTDPVQGWEGIRVELEAEAGSAPLSAESAASTANANAKQHRQEQLPNVSTFGWLCRVVWLGSRVQAETYRASGPPPGGPWNRHVEMDPLTSPEEMVAMDRVIEFIRSKLSDSVTRKAQMGGGIDGSVVMILLILNCLVTNLYHLRAASGLIRLPWDPSSEYAMQRCWQALHSQHEILSRLTQYENAHTSLHRSRANTFTAFIPSRVHCKLILTLVPTDVLYTIAFPAKFAIGDWTALVHSRDRSENVPAHLARNDLPSGDDAFPPSYFERRLAIVDVCCDAMDRIGEVWPVGRKTYSRSTSTVQPHHAPNTSPVRPPQANGYNGHASSHDGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2A1</accession>
    <name>A0A2S5B2A1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAMM1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2A1"/>
    <dbReference type="STRING" id="741276.A0A2S5B2A1"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38510" checksum="3CB4C04572EED93B" modified="2018-07-18" version="1">MSDTTSKKARTDQPILCTHSGKSGTFHADDALAASLLRVLPQYAQAELRRSRDQKDWDEATVVFDVSGEYDADKLRFDHHQRGFEEVFGHGFVTKLSSAGLIYKHFGQEILSTLLQEPVSSPVVETLYLKMYQDFVEAFDGIDNGVAQYVSSEPPRYRSRTDISSRVGALNPRWNEPSNDEVLLERFEKASELAGNEFKERLDYLAKAWLPARDIVKRAVEKRKDVHPSGKVLIFDEFAPWKEHLHILEQDLSIPENELPLYALYPESEKPDSKWRVQAVAVSPESFESRKALPEAWRGVRDDALSQLSGIDGCIFVHAAGFIGGNQTKDGALQMAVKALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Y8</accession>
    <name>A0A2S5B2Y8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Y8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Y8"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="634"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="698"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="760" mass="81404" checksum="17EC7EA351FC2A38" modified="2018-07-18" version="1">MSAIETTPNSSRFATQSQNSRTHSVRTATTSALDDQLPPARPVFLESALFINALAGPSRQPPALGVKNANGATSVPMQTTRVDGRSLGSAALPPGVGKDSKAGAAPPTRKRTVADAIDRENLHVAPVAGDERANKRLRANAGDMTMLAAASVTADAITAKRKQRKIDRGAGIEKLQQDTQQWRQKYRKAFPSFTFYFDAIDEATQLTLGVAVKRLGASVDNFFSKKVTHVVTTRPIPTASTSAVTGAGKENVESGSAGKANTSAAGRARKPTARSPKIYELPNGHRVRHPEGPLDQNPFIDSQDILAKAVDFGLKIWSCDKLQLIVDRINQVSPHKDKKGLQRDPSLPTLLRDEQLYGTRERDPVVPRNDMYYFPPNKMYLFVEDSTGEHRPIVIKEYDKPKRHEDPTWPILWGGVEGRTGFYHYDGPEITYERRVPPPAPAPVPAAGGATGYGSTAARAVAPNLRRAVSLQNVTRHQQAQYAQQGGAAAHAGVGRGEYLAASGNSQIITSNIASATSTAARSGAAQANRNGANPFVDKRLAVLSNRNVSVSGGMFAGSATSASASGAASAAGSGGVTSATAAVATLSASEGRSRVAALKRTARPTAGLKRSISVDAGLNPPRTAAPPAPPREEVKKPGYCENCRIKYDDFTTHVVSSKHRRFALNPKNWFDLDALLEKIERPVYCIELEEEPVRSPISLHESELDQDERRGSSEGSELQCDDSGYHETSVAVGHVVKEMEGMLAEASAMLSDDGDDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B369</accession>
    <name>A0A2S5B369_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="6" type="ORF">BMF94_5898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B369"/>
    <dbReference type="STRING" id="741276.A0A2S5B369"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="481" mass="51694" checksum="88B16EA626AF4B96" modified="2018-07-18" version="1">MTKARLVQTLDGHQDRSWHLAWNPAQPLLASCSTDKSVRLYSYTPTHGETVGPYRFSLKSTIPNCHTRTVRSLQFSPTGATLATASFDATVGIWCQVSEAGLDDGSGLATAAPHNVDDEWEPVDPLEGHESECKSVAWSSDGRLLASCSRDKSVWVWEAVGPADFECLAVLMEHSQDVKCVTWHPTDELLASASYDDTIKLYAADPYDDEWQCIHTLASHSATVWTLAFSPCGRYLASAGDDLVIKLWERVSLSTRAKDLGALGEAKRQEGGRMGPWTPGGVRIGIKEKWKWEERGQIEGLHDRTIYAVDWKEGGVPSSQGGLGRIVSAGGDGRINVIQMLEPSIEASKEAGESSDPSSAAAAADSTTKPTDPSLESADASEAMTADASPASLPLGPRHSLVAQIEDAHGVSDVNHVSWCTLSPALAAAKLRALEGGEDDPDQDRSGATVAEDKDPRWDATRDMFASAGDDGLVKIWVVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3Z8</accession>
    <name>A0A2S5B3Z8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3Z8"/>
    <dbReference type="STRING" id="741276.A0A2S5B3Z8"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="6">
        <location>
            <begin position="199"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="574" mass="61331" checksum="02C223A3936F682B" modified="2018-07-18" version="1">MAMLRQAIQRTPLLPTATPHGCTCARQASHYPASLSTATSAPPPPPAPPGQANVTQADLSAAYENPAWSDPAYLRRYRDPARRDVFGTNASQAAAGRRPAAGPSAPKRPLATRTPGTTDARNVEGERGSPMLQSTSARTIEQLDAAATADGTGNAAGKRQRSRRNRLEMEALWSGGDFSPPIPLESYKAQTTRPKHALLFPGSGSQYVQMGYFLRETAAAQDVWAEAEHALAGFEEWRKGLNLHDLPGEAGVLGRMLDETEAARRRETRLKDIKHHKLPLALESSLILGHSSGEYSAAVAAGALSLVDGVRLTRLHGLLTHYALSLPSIGLSPDYDAPPTHRGQMSALVLNPGHSHAELTEVIRQIRTSRQTSDDPDQQGCQGTVEVASFNSTTQVVLAGTRDGIMRASEVLCEREIASRAADLPVSAPFHCSFMAPAATGMQAALSSSSISLHTPSAPLMSGLDASLITTPSSLVSNLVAQISLPVRWSSCLASLPTQHSIRRLVFLGPGQALANLARRDAKLMREAEKAARATTGAQEPEADEDAAETEVISVATEKDMDRLREIWEEEDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B439</accession>
    <name>A0A2S5B439_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B439"/>
    <dbReference type="STRING" id="741276.A0A2S5B439"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="382" mass="42189" checksum="5369C194872B0175" modified="2018-07-18" version="1">MEATSLSCVDTVYSADAVEFCPGRPNLLACGTYQVVKDEGEERVANSPAPPGEAGEEQEAMPDSTSPDFTRYGRCLLYEVGQGGRSLKELQRFDGPAILDMKWSPRPRNDQTMLAVANAKGRVQFHALTEDAEEPLKVVDEVECADESTLCLSLEWSTRRSVTFDPASIVVSLSSGEICLLEGENAFEVTTRWHAHDFEPWIAAFDCWEPTTVWTGGDDLTLKGWDLRQGCDRPTFVNKRTFEGGVTSIQSHIERENLFAVGSYDSRVRLFDKRKPLTPLTEFDAGGGNWRLKWHPTDPSRLLIAGMHGGFKVVDFDGLALNGGVDSDGWLRPGEGKLHARFDGHESLAYGADWSDGGRTDDGKDIVASCSFYDHALHVWAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B479</accession>
    <name>A0A2S5B479_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000080">
        <property type="protein sequence ID" value="POY71566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B479"/>
    <dbReference type="STRING" id="741276.A0A2S5B479"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="212" mass="22775" checksum="AB037CAFEC29B098" modified="2018-07-18" version="1">MSVINLTDVTVQNNPAGFTDPYQFQITFECVSPIQDDLEWKLTYVGSAESDSYDQELDTCMVGPVPVGINSFPFEAAAPLPSRIPSSDLIGVTVILLTCSYNDQEFVRIGYYVNTEYGDPELKAQYDASLAEDAEEKGIKAPDPTQHIDKLVRNVLADKPRVTKFNIQWDTPVAAVPTMSSAPIGGVTSEALAGAPAAAAPPPPFNPYSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4C0</accession>
    <name>A0A2S5B4C0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5317</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4C0"/>
    <dbReference type="STRING" id="741276.A0A2S5B4C0"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="217"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="862"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="893"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="917" mass="98085" checksum="0A4F62453E2977C6" modified="2018-07-18" version="1">MPRKIVESSSDAEMEILPSTSASASTSRRTTASPRKRKATSKTDAILLSSSSSESEDAKPAKKKKKVADAKAVPVKTASSAAAAASAAATSKKAAATTSKNRGKGKKRGGDDDDSGSEYDDAGAGGASSDDHADGGAVKLEADDDDEDDDEDVKPKAKKAVSKKPAASSSKPKPAAKAKPVKKEADADEADEKPKAKWSFKPRAGPAAPGSKEIPVGDEGCLTGLTFVFTGELESLSREAGQDLVKRYGGRVTTAPSSKTSYVVLGSDAGPKKLELIKKHKLKTLDEDGFLALIGDRKADPNDPKVLEAKKKEEAKVKEAAKALTLAKDAPEHLTQLWTTKYAPQRLTDICGNKGQVEKLKKPKSLACGFKKPGPDAMNTFRCVLISGPPGIGKTTAAHLVAKMLGFDVLELNASDTRSKRLLEEAFRSKVTDTTLSGFFRTAGSSDGHEGEGLGVNTKSLIIMDEVDGMSAGDRGGIGALNSFLKKTKIPIIAIANDSKSQKMKPLLNTCFQMLFKRPSAQEVRSRVMSIAFKEGLKLEQGVVDQLVAGSQSDIRQIINMLATYKLGADAMNFDASKKIAKMNQKNTIQTPWTLYSKLFGPQAFSPVSGMTLNDKVEIYFQDHSIMPLFVQENYLRGKFQRAGGEVGPGLQLKNLELACKAAESVSDGDLVDAMIHGTQQQWSLMPMHGMMSCVRPASFCYGQGGGYPAFPSWLGKNSTQGKLGRALGEIQIRMRLRVSGDKREIRQSYLPTLFPKLVTPLIEDGVEGVQDVIEVMDQYYLSKEEWEAIVEMGIGEGMNGEQVLKKIPAQTKSAFTRKYNAADHPIAYYKPEAGRAKAKKIAPQGEAPDLEEAFVDEDLAEADVLEDADGSESDASADFSKDKMIKAKKPKGAAAAAAAKKKPAASTTAKGKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4J9</accession>
    <name>A0A2S5B4J9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4J9"/>
    <dbReference type="STRING" id="741276.A0A2S5B4J9"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="84"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="216" mass="22932" checksum="57999E28D8F80F67" modified="2018-07-18" version="1">MGKSSKRTLDQATASDAAAPAAMDVDATAAAAPAVADASPSKKSKKDKKDKSGAGADGEDKEVALEQLAEIAKPLAVKKTGKHVLRLVKKASKSRHLKRGVKEVVKSIRKGEKGIVVLAADISPLDILTHIPLLAEEANCPYIWVTSKESLGLASSTKRPTSCVMVAEKGMKRKAPKEGEAAKDDSKVKEAEKEFQEEYAGVKKEVEALEVAIPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4K6</accession>
    <name>A0A2S5B4K6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000073">
        <property type="protein sequence ID" value="POY71710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4K6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="141" mass="15388" checksum="716B92D4F689A36C" modified="2018-07-18" version="1">MARQFLPVFCAESRPVTRRSRRFLANDAKRADQTCRDRRPDRRLPTTCSITRCFECDEVATAEMAERGCLGTATSGAALERACGQLGENERKCRLCSPSPSLGFLPFTRSLLPATLSPRALALTSKALSPAKQVSATLAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4L1</accession>
    <name>A0A2S5B4L1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4L1"/>
    <dbReference type="STRING" id="741276.A0A2S5B4L1"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="99"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="388" mass="43697" checksum="F3A97BEE84CFEA79" modified="2018-07-18" version="1">MAATDSNTALFEQTKQLLSTFTQHPFEAHRLASSVPVRDLGRLAQYHGSLGGNTENYTRWTQGATDLTGVSGVSDEGLVMDAGDRGRATEDLKLFKEHISDLKFAYLESNAKLEFVNHILNPEGYQPVVKEAIDELAAQQAQEKLELKQRKQRVGELEQLIRREAEALEAELNRKTQHAELADRLMRECEAMETEIAMLKNKRSPSERLTIDQIGATLEAQDNELVSIGQRTKQCEDEMKALKPRIKSSKINIERFSQTAKQLRREQEERDAKGVQDERAEQGCEWCGRCFFNVIMIDTTMAMYKSLLGIHNAYAVGSPATALVFEYGPPKADKGSLRRLRIELGTDGRMSGAELLDSSDDIQDLVQLYLPSQDLRSLVQEVRTRFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4T1</accession>
    <name>A0A2S5B4T1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4T1"/>
    <dbReference type="STRING" id="741276.A0A2S5B4T1"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000044">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="309"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="499"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="787"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="834"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="871" mass="88253" checksum="BB3706B81D5E4F31" modified="2018-07-18" version="1">MEALPPPNVPADSLPRHLTQQQANSASTSSNASPAGTPPATSVPTFASASASSRSPAASTTALNAVGTSNQPAASPGLASPTSGSQPLTPGSPSTSSSNRFSLNLGFIARRPRGWTTSSVTGRSPGPNVSGTSLTASPSQEMPPSPSGGNERSTSSGYGFPALRRSLSKRNSSTATATVSNQQSGESSRGNSRQRRSASQPPVPHGSVAIAAAAAGGAGAASTSENRPSTSRSASQQAGFSELAATTSLPNPPERGTTEPNAGASTSSGVPGASSSGETFKIRLVPHLESSRSLHFEPIERDLAPLAIIRIGRFTDRHGAAGAGNANAARGTPQEPARIAFKSKVVSRGHAEIWVDEAGKFHIRDTKSSSGTFLNHIRLAGPNIESRPFPLKDGDVLQLGVDYQGGTEEIYRCVKMRVELNRGWQRGANSFNTAALAQLRALGGFPDPPPASSSSANGALGLSAMSGPPKAVTAAKPSTPTDAPAAASTSASAASITDCCICLYPVTVCQALFIAPCSHVTHFKCIRPLVEQNYPGFCCPLCRTYADLEADVEVDLPEPVVEPEAEPPAAEERTSDEAMAEADPADGAEGLGGLARRSPPMDAVLEADEPASRAPSIRASGLARSRPPSIAPGGADLQEDDVDMEDALGPVNEGNANSSEEDEPVGSASSSREAVNVGCEPAARDFASSVPAMAIASPSNLPTYLSPTMSEDAYASLASAATPPNSTFLSTLAESATGAARNAAAAVFGAGAVSQSGAAAIVPTSALARPPASLDAAILAEAGPSTVSLARSGSGSGTHGSDLESADPDLDGSSSEGTGEGQPNADRVEANQKAKGKGKSKEKRRSSSTSLFPPRDGMDHPDPAVAAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4X8</accession>
    <name>A0A2S5B4X8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5188</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4X8"/>
    <dbReference type="STRING" id="741276.A0A2S5B4X8"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="92"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="226"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY71827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="917" mass="103548" checksum="3B890B40A5CD8178" modified="2018-07-18" version="1">MTDDSPTATPRPPLSHQMSSVPNTPQNSAPPSPKQPFFGYRDERAHLTDAGAFHAELPVAALPDVVAGAAGSRVLTGQPSIERLSMSGLAISGSAVSPDSSTPTATRGRTTSDAAARAKGDLTSPRIANFALHRSPSKPSSSKPFQSSGKDGLPDGIWTAGKGEAAHGAPHLNSALEDAEEIDEGFTAQNPNEVLTAELRALYTSFQRCLDLRDKYMTLSRQRLEDNPANYDGSFTPESSPSYASTSSRLATNLPPSFRKWPIYPPPPEPHWKERDPHAEPPTETTAELAAREAERNRFVLADVEIPGKEAEGQQRTFALDQNGVYQVYAQDSTNPDEPSRKPLYTVPTIKEYFQDLDEVLAVISDGPAKSFAFRRLRYLESKWNLYVLLNEYRELAEMKRVSHRDFYNVRKVDTHIHHSASMNQKHMLRFIKSKMKRCPDEVVIFRDGKHLTLRQVFESLNLTAYDLSIDTLDMHAHQDSFHRFDKFNLKYNPLGESRLREIFLKTDNLIEGRYLAEITKEIFSDLQQSKYQMAEYRISIYGRNTAEWDKLAKWVIKNELFSDNARWLIQIPRLYDVFKKSGGVKDFEEVVKNIFQPLFEVTADPTSHPELHILLQRVVGFDSVDDESKAERRIYRKFPVPKDWNTTQNPPYAYWLYFLYANITSLNNWRHERGFNTFWLRPHAGEAGDTDHLTSAFLTSHSISHGILLRKVPALQYLFYLKQIGIAMSPLSNNALFLTYERNPFPNFFRTGLNVSLSTDDPLQFHFTKEPLLEEYSVAAQIYKLSPADMCELARNSCAQSGFEMEIKRHWLGPDWYLPGREGNLIHKTNVPNLRAEYRWNTLREEMDMIELVKSDLSARTAQSATLPAQSKSSPHRQEPLLTSDAVGAAAMSAAPNSLKMPGLAANGGKLAFPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B542</accession>
    <name>A0A2S5B542_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B542"/>
    <dbReference type="STRING" id="741276.A0A2S5B542"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="184"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="78364" checksum="76411AE917ACECDD" modified="2018-07-18" version="1">MSDEDALSRLPADVLVDAVLAAMAPRSLCSLASTCHRWRRFISAEGSPCEILWQRRAAKDFKFPVHATGRRTGWSRLYGRLASGGAWVWGVSHQQSRSQLLMGAGGPLQSYTREKELIVAELQTQAAQNGRLGLPVHSSVAVPDSIRKRLIRGGIPIPTQIRLPDSPAVIVAGGWSFHALTTAGEVISWGEMQPSTGMMPVRELSAPVCTLAPQRLPQMEEIGPIQQIAAGRDHVVMLGEDGQVWEFRSVGRVAALSDADGRWGAIADPDFEQRRAIASVHAGWSYSAALTTSGDAYIWWRPDMGKLHRAALAAGEAAEGYDNTRDGVAVPLQVTSLKLPELPLVEECAETIAKLACGDEFVIALSSSGRVYQLDVSLPQMRDDEMRSASVQQVEHDFITRRREWTYLRAFSELDAAAEGGDRVAPRISHITAHFNTFAAYSVPSSGAIANSVVLLGHKGSTLPQVIPELQNIGVIELAHGDYHNLALTLSGRILSWGAFSAGALGLGHPELPNTPLSPKPPADSADTAGRAAQVAPPAPAGLMQRAQAFLPPMPTVPPQLAGLLPGGLIGGPGPVVGARPRRVDAPDRVDKPTQVEFDTQLTSERKRNKKEPFVYSITAAGWHSACLAVELDDSASLAASVIPGETEREEGEEPVIDFHLARTAADHMTRNHTIRRADRDERPRTNATDATDELNGMTARVEQMRFDLAPTGAPSNPFGPTAPDARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B546</accession>
    <name>A0A2S5B546_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B546"/>
    <dbReference type="STRING" id="741276.A0A2S5B546"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="134"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="345" mass="39019" checksum="CA242277A0C1D30C" modified="2018-07-18" version="1">MAQSIPPPSIQLSLAHAGQSLDLSLAPDSPARDLQSRLARHFHLAPNSIKLVVKGKKLQLDDLGDRTVRDLVAGAMSGTKGGKALVIGTRATDLDALKAQEDLRRKKHDAFIRHQQRTSAAKPLSSARIRTIGGEDDPDHFRFHHLEPFPKTVPFHERRLAMLQKLSEDLAVRDVMKRHKFAVGILTELHPVLHTNHSTGEKLLGLNTNAGEKVSLRLLTDDLDGLRSYNEVRRVLLHELTHNRYRGHGNDFKELNSQLNKEVAAFESAPDFEPWDPPSSHGTTQEEHRLNEVEAERAWDRLQFGQEDLVDERRERMRSAAEARARRQQQSPPPAHHPSRSRNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B558</accession>
    <name>A0A2S5B558_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000069">
        <property type="protein sequence ID" value="POY71913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B558"/>
    <dbReference type="OrthoDB" id="10670236at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47232" checksum="4AE37E96206A606D" modified="2018-07-18" version="1">MAPPDAPAEAAAATDGGKLAPPRVTLLTLPDELISEIFGQVHAMYMCQKRNMPPTSYLCLNKRLSTLAQPIWLSVLSAPQERAKAESFFLGMIGIQDRLLHVRELEWTVHKGYPAYRVALVKSLRNLATLRLRATNVSAGPCEIGVWMAIVSFEKLQELVFLSPTTPFQYSYYPNLTTPRLECTPSDLKDHTILFSDLRLRLHQDEAVSQLRLRSLSSLEIVLDQSIAANPSNFVASLLLQIDRDSPDEPCPSLTRLSLAFKHVDVWLQLWETLSVCCRSSALSQIELHVPPELDLYTLDFDAWPNLQRLALIFNHCSSTSLAILCDFILGLGERKAFKLVGFDWRGDGSTEIFDDVPDDLLDYVYVPSLHLLLDILRRSTNVLELRLRSDEEVDSPEFRWTRPTSKDNFDVDSYDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5A7</accession>
    <name>A0A2S5B5A7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BMF94_4972</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5A7"/>
    <dbReference type="STRING" id="741276.A0A2S5B5A7"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20 25" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20 25" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="295"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="592"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1076"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1159"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1170"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="POY71963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1216" mass="135840" checksum="B0B5E51BF26F3DDF" modified="2018-07-18" version="1">MDGEPVNKKRRTTPDVAQGEPATLAGESTADALLLPANGNPADTAAATAAPALTTNGNESQATDSQPTPLDQVPDEDHAAPPSTAAGAHAKPLSALFKAKTPSPKKKRVPGGKPLTRVGSNLREDNKENFTELLARLNQDNAIEEQEKWARPAAPKLNPQRDGIVFQQIDIEEHTAAGGAPTIRAFGVTQKGNSVLLHVKGFLPYFWVAAPRGFTNSDCLPLMEHLNTAHFNGGRPISNVTLANKRSLWGYKGDSVSPFIRVEVVDTKQYPKVRNAFERGEVQFKDYFDGSSLMTFESNIAYTLRFMIDHHILGMNWLELKPGRWEHSKSPVSNCQYELECQHNDLISHAAEGDWSGVAPLRILSFDIECAGRKGIFPEAEIDPVIQIANMVTRQGDSKPFIRNIFTLNTCAHIVGSEVLEFKREQDLLSKWRAFVEEVDPDLIIGYNTSQFDIPYLMDRAKALRVTDFPFFGRLKGVKTEVKETHFSSKAYGTRDSKETNMDGRLQLDILQVMQRDYKLRSYTLNSVCAHFLGEQKEDVHHSVITDLQNGNAESRRRLAVYCLKDAYLPQRLMDKLMCFINYIEMARVTGIPFNYLLSRGQQIKVISQLYRQALKTGYVIPALKQEGSDEQYEGATVLEPEQGYYDVPIATLDFASLYPSIMQAHNLCYTTLLDARIAQTLGLREDEDYVKTPNGDLFVKEHKRKGLLPTVLQDLLSARKRARAELKQEKDPFKRAVLDGRQLALKISANSVYGFTGATIGKLPCLPISMSTTAYGRQMIDTTKKEVEGRYNTANGYDYDATVIYGDTDSVMIRFGCPDLETAMKLGAEAAEYVTSKFIKPIKLEFEKVYFPYLLISKKRYAGLYWTKPDKYDKMDTKGIETVRRDNCRLVVTVIDTCLRKMLIERDVKGAENYAKQVISDLLQNKVDLSQLVITKALAKADYAAKQAHVELAERMKKRDAGSAPAMGDRVAYVIIKGTKDARAYEKSEDPLYVLENNIPIDTKYYLENQLSKPLMRIFEPIMGERASSLPRFHLPLRRTDNACLSVAGDHTRTVTIIAPTSGGLMSFAVKRVTCLGCKTPLKPNALNQAVCNNCRPKTAELHAKQVALTSQAETAFARLWTQCQRCQGSLHQDVLCTSKDCPIFYMRKKAQKEAVDSVATLQRSDGQTSSTSRKTSTRLPSTKPSLRNKPKLFSLSKPIRAKKFEGGSLSSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6D2</accession>
    <name>A0A2S5B6D2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6D2"/>
    <dbReference type="STRING" id="741276.A0A2S5B6D2"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="403" mass="44402" checksum="F44AD1B68830F0E4" modified="2018-07-18" version="1">MAGVTGFDARQGQLKRLLRHYAALSPATPTNIRLAVLSDADYLSRPTTQQWVVDNLIAFEGAKNEQEDDDDEEERGAKRWKGRFWRRMVDQINEGFAERRAAGDIAVEDEEPHPDILETFVLYLSSAGSTDSAPGVSRRTYYWGPLDQPVQSWERIVTKEEGKLISGACVALSNHLLADPRTVERHEHVIELGSGVGLLSLVCARLSRRETSPAKRRRIVATDVDDKVLEMLEANIAESEPCDDFTLGIECVSDRTFALKKDGFEDIVRASPLDWELVADADKNRDELALWEMKTWSGGPRASLILGADIVYDPSLVDPLAATLAWLLRAEPGAGSAPEALIAGTVRNEVTWASFLDACRARHLNVTAVQMTAPPQDGGIVGAEGWEGEGEIRLVRITSSEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6U6</accession>
    <name>A0A2S5B6U6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6U6"/>
    <dbReference type="STRING" id="741276.A0A2S5B6U6"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="248" mass="26589" checksum="125702D670A07327" modified="2018-07-18" version="1">MENIWTAASSGHLDRVRELVESGTSPNALDENSYSPLHAAASWGHADILRYLVDRGGNINLTDSDNETPLYVVENVAISKLVVELGGDPNWTNEEGLTPAASLQEEYPHISLYLRTLTGEAAPASRDAPIATDDDPASPATTTGAAPQPDLDAPTDALMASVRSIMERSERGEISEQETDDLLREVVESAVTGQVEAGRAIGEQMVVDEEQQQHGTAAASSRTRTRTADQLAEEAPGKRARDTDDIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6V4</accession>
    <name>A0A2S5B6V4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4338</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6V4"/>
    <dbReference type="STRING" id="741276.A0A2S5B6V4"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="291"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="724" mass="78796" checksum="68A87FB337C513FF" modified="2018-07-18" version="1">MTQPSPTSSLEQEEHAASGPRASRSSRVSRSLSAMGFFQQNEDSSESTLSSAGRRDSASRDTLDPAAYGVLTGAVGGSFGPFPRSSTFSTSRPPAFSHRDSLASSSIGLDPVSLPYGGATSADSPRMTEEEYGSQEYVATSPQIQPSNSRYSVSRLEGIAGGGAGAALLWEKEPDDFLHDPDPALDKAMDKQMVKFSIMAFVNTAALLIVVIVLVGLFAGWPIYRYVIRRPGSSGLVPELIFSLITSYAIDGAWGNYAAQTITNSTGQVPQIPNLPSLIDDTTPSDAYTRTGFDGQEYELVFSDEFNTDGRTFWPGDDPYWEAVDLHYWATKDLEWYDPDAVVTEGGDMVITMTQEPWNGLNFRSGMVQSWNKMCFTGGYVEFNVSLPGLPTAQGLWPGLWTMGNLGRAGYGSSVDGLWPYTYNDCDVGTLPNQTWPNGTDPVDAKKSGSTDYGGELSYRLSACTCPADADEHPGPSVNVGRGAPEIDVLEGQISPDGTRGWASQSIQFAPFDPGYLWRNDTEAANPGLQVWNKSITTQSAISQESASFNTLTDATSFEGRGYSTYGYEYDPGADGRITWAINREQTWQLNAAAMQPNSGTQIGQRLISVEPMYMIMNLGGFHNAICAPRPCASVAADRASSYAFQTPQWGKLQFPAHFRIDYVRVYQKSGQKNVGCDPKNYPTSDYINNHMDLYTNPNMTMFSQSNYTTPRNRLGAFGCSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6V8</accession>
    <name>A0A2S5B6V8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6V8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6V8"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="334" mass="37425" checksum="1AF6D0168B419F33" modified="2018-07-18" version="1">MSLPTVQFAGQSVGKIATGLMRLTWAPKQTPDEQAFELMRVAIEEGATFFNSGVFYGNPPDATTNLQLISRFCEAHPDLKDKFVLSVKGGIDTESQWEPTANIDFLRAEVEKINRILKHRKMDMFEVARIDQKTGIEGIMKNLLTLRDEGHFKYISLSEVGAATIRKAASIGPVSCVEVEYSPFTTDIERNGVLDACKELNIPIAAYSPLGAGFLGNNWKSKEDIPEGDHRRTFDKFSDEHFEHNMQLVKQLEEIAKKRNVTAAQLSIAWVGQQWEGILPLPGSTNPDRVKQCIEAGKIRLSDDELKQIRSIIDNFDVKGVRYDKGARQAHLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Y0</accession>
    <name>A0A2S5B6Y0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Y0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Y0"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="3">
        <location>
            <begin position="383"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="708" mass="78866" checksum="7416CFA7D23E5D0F" modified="2018-07-18" version="1">MSVSRATAGFASLVFRCAAFVFLRWIPSKWVGPYPLPVTFALYTLATYFVTSAIPRRPTKPAEAALIPEHDAPSFAEVTAGGKPDQHGNAVHEEHPHVKPDPEVPSNGARELLSKRQKKNRKRLQTDPLGLAQSSDSDADSLALNRRQKLARNRPLPKATVPQILNNLIVGTPTPTSRFLNWCAWGVNATVFALAIDAIVSPIVGMEQSSLAFARVGAISHSSVKLVARIPPASSLLTAVPIVAGVVPANNSEPAIEKFLPDDEFIGAKVMYRPTKPIGKWMAGPEIRTTAEDDWVSTVNLDGLWAATEYEFRLLRASLETSHHPAFPHSQYFTTFSDPALTAIGTPNEGTHYTFASSSCVKPGFPWTGPSNKLYTKGATDFLKVAERVGVRFMLFLGDTIYADVPWYSGANVKSYFKHWRQFFASPQVKEMVEKIPFIGVYDDHEIYNDYSSNETSPAFAPANHAWKAYLGNGNPDPRIPGVNYFDFQFVRSVSLTVGKIGDSAFFIWDTRRYRSDNAAEDVESKTMLGLKQRQDFFDWAARVNETVTWKFIVSSVPVMSLWSHGEDTWAAFLSERDAIMDVLEYVPNVIVLSGDRHEFAAASLRTTVTEFSTSPFNMFYLPIRTLSQKHHRDIPDGNTKFTTFEVDTRIINKPMVRVKIYVDGEEAWHVDVIGKPLPRKLLLPPTAVGSLGKGLRELLTFLKRSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B745</accession>
    <name>A0A2S5B745_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4377</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B745"/>
    <dbReference type="STRING" id="741276.A0A2S5B745"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="449"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="745"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="607"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="783"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="954"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="891"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1074"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1116"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1153"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1196" mass="130229" checksum="B21C704318EA8107" modified="2018-07-18" version="1">MASTLRASPSWLASLGQSPSETSDARFKTFAAKDSPPRTRGAVGPGLFDDDKGRARRGSERESLEDELADLEGIGGGPDGAWLITVADITKTDPAGAKSDGRHTVYVSTPTSSLTLLRTYKELLDVHARLSSAFPPPSTATRPTSKAPPSPRKRNVLASLTRTLSPRRNGSFGSFRTPNRTSAVPTASKTDALALTNALSSFSMRSAAREHPAWREFFAIRADDLKSDRVERRIKRYRSDQTLEVSRNRMSDPFAVESVGMSSSRSERQDDSTVTNTSMATDLDNTSIAPVHVSLYSGDEGPSASPEVDSHWILGPDADALPSLSQVKIASQSDPQTPTSPEKARPASDTSMLSSTPTIATDVDRLRETPLDSVTESVQEPRSPSQNGRLLSPLPQHASSNDRSSWQGSVEATNRGPMANGMTRSASDYSMGTTNSVDRRSKAITLESFEMMRVLGKGCAGKVLLVREKKTERLMALKAITKRHVLAHRELEHTRTEQAVLKACAREDLNPFVVKLHYSFHDEETLYLALDFHPGGDLATQLARWGRLGRDRARFFICEIIEGLDGLHRAGIIYRDLKPENVLISAEGHCVLTDFGLSKDFQHAQRGARSPASGLPRPHWLQHNARSASTPPGSEWLLGNRETTLSFCGTAEYLAPECLLGEPYSYEVDIWAAGTMLFEMLAGVAPFWASDHATMYKRVLHDELDFHQAPDHFDHDARVLLRGMLQRDPLFRITIPRIKRMPYFQQISWDFIREKRYNPPFVPTLNPLDPTDTSYFEDAFLMMPPQVKGDPNDDPGAGRDPPEGKAQDPVDKDGRDVFDGYSYYGGRDSASIHDHDDDDDDDRETDAFAGFGVYPDGAELDQAGQPPPLSTREDVVTGSDEAALCNGTPETVKDSSSVRERPDSRSEEIDDEDDIPQLGSPYPELILGHGRITSLQPSDSMNPQLLSAKLLQHRAPAAEAGPPELVRQQAERAESKAVGPGLSTVTLADVHEQSTAPQQADVTGAFDALTTSHLDDGVADDADDWVALETGPTVASVRNGGREATLWDRGFRDRYRMTLAPIGSPLRPPRRSGRSTQASRAGSTSSAISSSRMSPASTPDPPASPRPLGLIRRFTSPRQSLNSAVVRSHEGSLDSGSPRPNAARTSARLGGKTSKTSLSPSGTSTVDRASSTGGDSRKASPIHRLAKSASGFIEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B751</accession>
    <name>A0A2S5B751_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B751"/>
    <dbReference type="STRING" id="741276.A0A2S5B751"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
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        <location>
            <begin position="80"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="302"/>
            <end position="469"/>
        </location>
    </feature>
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            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
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            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
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            <begin position="31"/>
            <end position="43"/>
        </location>
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            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="509" mass="54428" checksum="5991138E796D26D4" modified="2018-07-18" version="1">MLASCALATRSIPALLARSIMSTRGAARPLSPATPDSPDSAAAPHKRQKLDHDDGTAPVEVPLAKTPRKRTLPYERGMHLAPMVRIGTLPVRLIALDYGAELVWGPEIVDKAIIGAERKVDPRTGVVSFCKNGRSIFDCHPLEKPRLIFQLGSASPELAVQAIKVIENDVAGVGLNCGCPKSFSLSGGMGAALLKEPEKLCSILTAMVDATDLPVDAKIRLLPLPPKGADTPNAASSSLATPAATPPLAAAEAAHTTPSAVFEPTIPPTLTVPSETASLSASPKTDAASEQAEAKTPVIFEDDEPTHALVERIFATGIANLTVHCRTQEMRSREPALHERMRGITKMGHERGIPVVCNGDAVGGGKEAGWGNFDEVCEKTGVSSVMIARAAEANPSCFAKSGLSDPITKVIPRLIRVAIATNNHYSNTKYILNAMYLFSSPTPPSRETNRDIKQKMNKAKTYEGMAAAFGIDAEEVQQLKEEADVRRIEELVPRWTARRNEIVEDEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B769</accession>
    <name>A0A2S5B769_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="336"/>
            <end position="427"/>
        </location>
    </feature>
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            <begin position="20"/>
            <end position="32"/>
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        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
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        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="45771" checksum="0E7B562C738F6F12" modified="2018-07-18" version="1">MNKIKQVLSHNSTGNTTHGETTHTGEKTHRATGDVVGPPTVSSAGDRVDDAAMLGLKNRDNTVGSNAGTGLRDESALPTTDATHGTHGIHGTGATDLSSGQHTAAHIKESALPPTHGHKHGTRDSTLTEDDAKAAVHDHQHLAPVVHERRHHHEVEEVERVREVDRHVHHVQHHVQPVLDEQHAAEQVHQKVVPRTEIRESHAATDEDKHQFLSLNTVKDEVVEAPRERTIIDKGEVVKENVHHVVHHVVQPVIERDTHEHHRIRTTIPVHHTVVEAPIVHASVQHEPLSLKDFVAGGGDLKSTLRHDPETLLNHGKCERTVEGPAETLVQQMGLSSLNDSSSTTSGMKGSSLAGSQGTTGLTGTEHSSGLLGNKHSTGTEHSSGLLGNKHSTGLTGSENSTGLVGNNHNSGLNPIDGAPAREAGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7N9</accession>
    <name>A0A2S5B7N9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7N9"/>
    <dbReference type="OrthoDB" id="2529966at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="490" mass="54580" checksum="82221D3DAB5E9B8C" modified="2018-07-18" version="1">MDTYASQSLQTINYLSPANRYVFPKLCNAAGFTDVEVYCAKGTAGLCCGLCPNTSVNGPGQFVWAIVSYGIAALAYTLAPSEVWGVAVMQNLNAHAFIVAGMIRVFAGAETGGMAKYMTQFLWPQALGFIFIMAPAVMAPQWSRLGKTRADMEHKIFKHHNKLPEQASRGDLRIIERGLLKKHHSTSWGWPIFTFWFLSMTAWTFLYAYVTFGDIKFFQSACEGHLDYTLSPSVATCILGSIAWLLLAFDGFLLLQKPERRMGGSDYIIEFWLPNPAKERSAFDHRRLERRITVGTTAGLFLLWLGLNCWMYIEGLNRFLLSGADYMTFGQVEQLTALFPDLLALYLGIHGYLKSRDQLRETRGQITAEATRATSMDQTRDSEAWGLPNLERTPSSNSWRSLRSALDKVNTGTLDSLTSRPARWASRAYQRHSETSSDEAHQPRGRLGQTESLSSGAVPRPESLGSHSLTRRSSGVTESEGTHYARGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7S9</accession>
    <name>A0A2S5B7S9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7S9"/>
    <dbReference type="STRING" id="741276.A0A2S5B7S9"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1090" mass="119600" checksum="B0C5444ED0CC8E50" modified="2018-07-18" version="1">MSIRLNDEDATIEESGQDAAPGRSELARSLPAQRETLRDVRECEDVLQVDPLSGRGMQIFVKTVTGRTITLTISSLDTVNDVKVKIRIKEGIPPDQQRLIFAGKQLEDGRTLSDYDVQKESTLHLLPRLYGGTGTSDLRAAVNRVRKRVVLPREVCQRIVIVPDTHAILHFALAACPDEAERARIAFKYYLALSTTFVSTLVPNEGLAKAGKVDRATKPPTNQAHLTGTIPLASGPVYHAIRTAQHAMLELTRGTHSGGVPAFDVLGTAADGDSNQMYLTAMLQASGIKRATEEDLTGSASSATRYKLPVDVPLTDADFSAYAEKLGTLSLGHGEVRAGADGIVETLLRPADDAPKQLFSLSLTPDRDRFLGEDALVALNVVTYPSYVAIDYAETGAVWRNLGESIATEDAAWVFEQKAAIDGDDPRRESAVAYPSSLDGRIQASNSQSATAVAFRRLATESAAFALCQLGDYGGLRTGSGWGEKALRRLYQLCKGNMSAIWDTLKEEGVDGFYGNTSLSPFCSFLFPLVRQFIVPFVPAEAPSLAAAAAATSASVYLVEGQLPTTLRRKAIAALLPLLPPTSATTVEELDQAGPIFPVLNLLQIVPAQGFIAETPPSDAALPRSWPFGPGLHDAPLARPLMQSSWSFDHFAPEGTDASTDALLRAPGLTAKAASTSIETLRAQFRREDDETRERVFVMPWDRDREIDADADGEDDSDAVAEEEDGLTDDDDMYEITPEEDARMRARASATALERHRRERQETLDRLHALLQERFPNLRDVDPSRIPFKPTCATMLVSFLENEEFFHRVFQPYHSSYMILDCEVIAVARTCAQTWLPHVLRTFARFAGFHFYTSIHQRLSELSQAGGTSSLLVNHGSIIPLILHNFKVCHTSFRNCLVAVYLTSDLVSPDAYWSREQAPTFKAVEKALTQPQTPDIVSWSGLSYSEKKQSWHGLRYIRAVYNLSPLPEAGARQRHSATPNPPKNLLNKIIGSWRTKTSGQLSNIAISTLDTVIFKLGGPFAYTGGLGTVSNANDMSRSEEEVRFSRKAKAWSMLEEIIECATGEKGRSTYFGGCAIDWDRSYESLYIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7X3</accession>
    <name>A0A2S5B7X3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B7X3"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="463"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1381"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1493"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1141"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1718"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1763"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="869"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1155"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1180"/>
            <end position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1804" mass="200504" checksum="D949D9C3522E0414" modified="2018-07-18" version="1">MAPVQHVFQDALAAAVKDACRAESQDDMPASDDSIEIVSAGRKRNAASPAPDGPARKKKANGNSELHPVLKLDLHFEPPPTTEVAVRKVLSKYGKHLVDSGGTVPLCDVVYHHARDSAKTPHRLYLRHADTNAALVELDPIDSACPAARTWVQWITPPPLTKSGKPYKRPKNASRAQKRDPNAVVPNGAGGLVDALAYLGDSDGQGVSVKYAFLLEVDTEDNESEAGTIRFHLTFDVSVDPADFFSALYTRSRRILIDHLLPSTNPLGPGATPEAPDEASVDFFYACLRRAPRTSNGLPISPGSSPAKTPEGRATPIETDEERQTRLRREAKGKQRAIEPDEADEAVDRTGDFDQEGAAGDEDELIYPDGLSVKLMPFQARSVRWMLAREGKRIKPRKPVKLPIIDARTGDVVKERELWLNRTLLSFTESDPVDIVGASGAATPIKPESDGEDEAVQEKASRKVVGGREGHGLLAEEVGLGKTVEALSLILTHRDDDRRKLPAYFNPVTNSEVQPCGATLIIAPTAIVGQWESEIARLAPDLRVLRYEGVKSLKDKQDKKFLASRYDVFLTTFDVLRKEVAFARAPTQRGLRNKREVRYRRSLLVELDFLRVLMDEAQMVGDAYGPTSETASLISRRFSWAVTSTPLRDKIADIKPLLTFLRVEPIASGTASIQRLLEETTSFKRLWNEIGERTLKSQVQHELFLPQQIRYMVPIEFTSVERFYYDQRYHEALTMLGLDEEGRPSHNPFAPDRVWEADKGEMLRALTTLRQLCTHPQLGASNKEALGRVLKTVDEVYAAMREKAVSEIQSEQRAMLQARVKRAQYEMWDKEDTEERFQRALDLFKAATNEVEPIITEVTNEIHSTWQARKKDPARDGSNEPTDKGVAGALELGYRSETVEDNQLMTETERAVSARVSALRNRLRDLLFVKHSSLFFSGHACFNMKRSEEETQFYQTAERLRQTILQPYENAVERAQTALKRQLDAREADHELSVEDFELRFDSKGHGLRAIKTFEDATLTSDLMNGYAELLYSYRDMIIQMLFKAVSIAGDDATGEEYEERAALQERLNVYLEAYTVLVGEWTYGVDGTRSALSDQYKAEMSAYLYKQEVLPVPGSPPPGGVEPDEPIDNVEDAVKDALMKVAGPSGRSGKQVSTEEDDEEEEAPADADDGDFEDESGKKKQGGKRKPKQKKEKTRVQAKRGANLKANSYKDFLAPSLESGHAPADVLRYELLVERLEAKGEDNEFAEVTPLRQLIKTLKEAEDNAGSNREEKLLERERTRLQGYLASLGKVADRLRAELSDFNKAFNARVTYFANLQQISDEVADPDMDSKNWRGLLIEIESLRQEELEHKAAIESKQSRRRYLDNLNSPDAREEAETTCPICSEHFTQGVLTNCGHLTCSACFRRWHSQSKNCALCKQQLGAGSYTTVSYKRAPSPALRDENDTPQNYLDSHGVEHAFETTAPKLSEIDDELHSTISSIETAAPLSSKSDFIVKHVKYIRRRDPDAKIVIFSNWQEALSLLMEAFTRNGVQYIRLEGATGKGKKEGVVKRFQEDPDIAAFLLHTKSQAAGLNLTVARYVFLVEPLLHPSLESTDAEADFSHAPKQLQAVARVHRITQTKDTFVYKYAVNDTVDRRVEELRASQNTSLFVASKGVNAAKESRLVQQTERASAAARQAAKTDELIDDEDQLAQILLAPSAFQNLQRSLLPDRLRTQDHVARARSAGETPQPEAGGSGHAAVGAIHAPGAAAAPAAVAGIAAAGRAAQRDDAEEYEAFAARRGDDDAIEVEGEGVAEAGPSGLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B837</accession>
    <name>A0A2S5B837_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B837"/>
    <dbReference type="STRING" id="741276.A0A2S5B837"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="378" mass="39647" checksum="882268763A35FE2B" modified="2018-07-18" version="1">MSLSLALPPSAALLSSSRPVQLAQLHPVALASILDSHLRRQPDHDRVFGTLLGVRRSASSSSSTDEAAVSPSTVQVTDAYAVPYAVRSHGGQVTIDVEHHRAVLDLHLKANPRLVVVGWFATHPTLNSFSALIHQFYSTECTTTAAGQNAASGSGQQAVHLALDPDSLEFTCYTASPIGGQASNANGQEAHFAFVPIPSTVVVPAQERPSLDLLTERLSSLSALVPNAATAATLSSAQSDANPATPLETLYSLLRQVTAMLDQVLAYVEKVTRGEIQGDEKIGRALLETVGTVPTRAANAGSGVAASEEQGGEVDEAAVEKKKSSKSGGARSADAAAVQQVDFEEEFNAHLADVLMVSYLANVIKTQAELSSRLNLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B843</accession>
    <name>A0A2S5B843_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B843"/>
    <dbReference type="OrthoDB" id="10525918at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1177" mass="123203" checksum="CC1A768F53E7953F" modified="2018-07-18" version="1">METHRVDAGTVKDLVEHLLTGAPASPALRKLVSPRLKISVSAAPRQLAFLDAASGDDAATLFKSYKLVSQAAEAIGLQWTARFLSVDETSLRTSSAPESQCARSSETWTAQVEWQLMYEPPRAPGQSAGKRFKLWTSSPRTVELVFDARHATSSTPPDTHTRVGTVELVIHAAQAERSGLELVAGKYSVWPTLPFPLGWVDAALPYIVKHGISTVQSRLLFAGLRLFVTVFEPDQLEPTVPIASLLPDPEAPAPPIHLRHHQRHYEPELQAEPGSDEESGPETQEPSHHYHRRRWSASMPQHTTPATTSAAARLHLERPLAERHLQPETAQGDAPRPREPAHAHPLPSSSGLARRGHVHAHQPGHPRHAHAHAHDHHADAHAGQHHHGHRHGLLYRVLKFPLELVALLVQVVQIIFFDFAAVSEFFGRMVEALMASVVTPRRDKETPGRFVQVEAEPRAEADHSRRVSFAESEPDAIPLNPPPSPHLGPIAEEGPASTTTPPPEGGAALESPYPRTLDSHGHLVSSSLIASLPIPIDVDAHALALHEQLASEAAAQGHFRAELEEAGVIAPPKVVPVSERDVEVHREVAKEVARVAGSMEHVERMAERFAAGGPELGELVEQVGGDSTRSRTLGEHSMTSSPATQVVVGTSEAGEHSPLQAATAPFAVEPQTVISPIDRPGLRKASSAPPSSSKGSAGQQGEAGAPSDDDSRSFSRAAAKLALQGRLGLIEPSSRPQASEPSATKPDSSETATPEALLQATGGAPQSESRRTSVGSITIGSSVGEALPRTFDDDEEDDGLAPRMGVPLTSTPPPPPPAEPTSSASDAANATSIPILPSLPIDDIAISTPPERPATAATTVQDPLMVMHGLGLGPEWRAKLSGAGGGSPGRGGVGVGVGGLTEAGESGVVWPYRQQQQQQAAGPSSGEARQPEQEQEQQQERSVDPPVRVAQSAQPVSSDSKLASPAIAAGMVRSLSYSPASATLSPPSGSVVSPDLVRSASDAGTAPTQIGAGANVTSPSRLSDTLSGGSPASLRMQHELSSSGAFASSQGRLSTTSGSPPSSSTAASAGASGFAVEVAQGESGSSMGLAMSTRTPPPTVRPDDPAGLEIHPAHGYDEQVEKALERATLSNAVADEQTTAPGTSSEGNGNNRSTGRGGGGRGGGGRSGHRKKKSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B845</accession>
    <name>A0A2S5B845_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B845"/>
    <dbReference type="STRING" id="741276.A0A2S5B845"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31104" checksum="D92621790A65509A" modified="2018-07-18" version="1">MPSTSYPHYAWAAGHFAVLLGTALTFLGRGAKTYKIAYFGALVSWGIVVYKSLGAPQVNRAYLQRALLDENVQYLLLALYWFLQKPIYITLIPFATFSLFHALTFIRTSVLPKPPAVQKPATGSGQAQQAQQQAVSAGAQASKVIQTWVKANYEKAMLFVAFVEVVLVFGRVLLGAITFQNSLLAPLFFAHFLRLRYYLSPPTRQAFKWVSDRVDQYTVQNPKCPPAVGKAVKVVRELFGIERREGSRTEVGRRSDGGSGTGMDKDFGRRKLSGSGSRQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8D2</accession>
    <name>A0A2S5B8D2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8D2"/>
    <dbReference type="STRING" id="741276.A0A2S5B8D2"/>
    <dbReference type="OrthoDB" id="2612513at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="236" mass="26397" checksum="A2D45AC20AAF4E35" modified="2018-07-18" version="1">MGLKSLLSKPSDSQPQQATLPPYSGNDAKTPVISQPPAIQAYGTANLQPIELHVYKEGSLFGMDDIITGPDKQQMQYYLHFPVKFLSGRWDLSLRQGGPQGPEICQIIKGGSWSNSFEIRWNGGAVTPVQQLGTFRMRYEFPASQEVYIWKSDNLMTSDYHFSLYKSSELGLPKEQRTLIAHWRTSIATFSKDGCLEIHPHFSHEVELILATALGVEVLTEGADALRRSRDSHSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8G4</accession>
    <name>A0A2S5B8G4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8G4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015528438" evidence="2">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="449" mass="47684" checksum="F029960848476B63" modified="2018-07-18" version="1">MRSLLFTLLGLCLSTRALAATQCVTCPNTLLPADAGFTAPVFYAALQYYDYAPESSRVLCLVPGVVSWRSCAYDLQGKLAGFTAFSLDYDDDFPRPTSKKRSLGRDKLLDKRGAEECPTTITAYAAGGSSNSQNGLTACAVVEKPVEPKPPTDPKPPTDPKPPTDPKPPTDSKPPTDPKPEDTVCDTVSNAVQVGCAFVSLTESTLGKVSAPCEAVNGLTTALLKLANIRETVDNLREAYVNEDPFKLGLQISGVAAGIIVGVLYGAELASITGFCRVAQGIEAANFLCFGSDGLTDAIKALACSPKRQREKRSLPSEQALRNQRRSHTLTRRETTPCQAFIDEFESLFGTEACALAGASIDCSRYSVESLTPLLGAKQAGAFLEQCPVLAQTAQFFDVTCALVDAARTIEVNGYCRAGGPQKPGPSALARRKARRALTLDDAGPQAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8X3</accession>
    <name>A0A2S5B8X3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8X3"/>
    <dbReference type="OrthoDB" id="10679361at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48934" checksum="5A7EC9ECECB194B4" modified="2018-07-18" version="1">MARRNKTSTAKKPPRAAVERLPDELLQRIFEPALLAHGRQTQSEPSRKQHLSYLPANEYLTLSKRFYALLRPVRLRRATFDLNKEKSTLALAKDAIADELCQHLRILSMVVGLGFSPLYAVALAQLRSVQSVRIQFHSDLQRTKPGRVEMPEMLIDALTKMEHLRELAFSEPIIVTTPPAHRFTALRSLRTHFVSLDAAAHALWEGVKILSIDVGGTFHHVHRQKVIGLMPWAALELVKITPSPGNHECDLSEALRLCLRQTTLLTNTARLSTLRVSAAIVVPVETMRYAIELAESLHCPRLVCSLSQELVVPLFGISTCLRELVFHAVLPLHNVYYLNESYKLIDSLKGSRFLQVDVAMSRKHSAPSGDKLAEVDEHRMALTYPVFFAFLYALAQTSLTAIFARAVGEDVRACWSRQTTAAAFQRDPTRDQKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9D0</accession>
    <name>A0A2S5B9D0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9D0"/>
    <dbReference type="STRING" id="741276.A0A2S5B9D0"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="6">
        <location>
            <begin position="183"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="5">
        <location>
            <begin position="420"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="546" mass="59398" checksum="2DCEAA3242A4880F" modified="2018-07-18" version="1">MAKRLTLAEQLSRIAEPAPQDFDPEEAYATYADGRATDNNAEAINAAQADYVDVGTSKLRKKGEAVLDAKYDGKKGSRAAIFGGDEDTASEDEEEEGDLEDDEDENDKMGSYEDLEAEEAGDSEDDDESESDAEVDSEEDLDDDEEDAVPKRKASATTGTSSRAKVQDERAMVSQLKQAASADVEKGRAVKKQLAFCDSLLESRIKLQKAVGAANSLPYPSKAPAYYQAIGQDDVDETLRDLAGLSEELFELRQELLSSNEKIEMPADFGVSRKRRRTSAAGDDHEYLDAMLSDLQTLETTFDPFLRATVTKWSDKVLAASGLAAGGKGDKKFKAVNQNAMAQIDHALSATGERERLVRRTKVRRGEGKPVGAVAAAGHGDEEEENVALTPLDGGASKPSGGAGGAKEVDDECFDDSDFYQQLLRDVVESRMLDLDDATMTQLRQATALARGKKIKKVVDTRASKGRKIRYHVHEKVQNFMIPIEAGNWHDEQIDELFASLLGKSFGNGAADSQKQQPQPQLDPALDDMPNQQAGQIEVGSLRLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9W1</accession>
    <name>A0A2S5B9W1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9W1"/>
    <dbReference type="STRING" id="741276.A0A2S5B9W1"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="122" mass="13539" checksum="118B0DF18A30D493" modified="2018-07-18" version="1">MSSQPLLQRSRDKRIALPVRVEPKVFFANERTFLSWLSFSVVLGGLAVGLLNFGDRVGKISAGMFTLVAMGMMLYALITFHWRANAIRKRGSGPYDDRLGPTVLCLSLFAAVITNFILRFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA53</accession>
    <name>A0A2S5BA53_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA53"/>
    <dbReference type="STRING" id="741276.A0A2S5BA53"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="232" mass="25063" checksum="2A62D94636ED7546" modified="2018-07-18" version="1">MLSRLPRSTLSSWATLSALPLSRVTYLATSASPLCSTSTAASNRAIAATHLFSASTRTLVQPATASNAPLGGRASQLPRRQFRDQVGERELPELKSRAPLYLALALVVTLGWGGFLAYATNAERANSSVVRSLGFQLRSWPAVREFLGDGVKIEPLFADFVRIKGSINMLAGKIDVQFRVRGSKGAGTASFTSIRRGKDGRFEVLRWKITRDDGAVLDLTGLDLTKPLEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA65</accession>
    <name>A0A2S5BA65_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U3 small nucleolar RNA-associated protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA65"/>
    <dbReference type="STRING" id="741276.A0A2S5BA65"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38642" checksum="C490605114E4579F" modified="2018-07-18" version="1">MVSKLKLNEQKRQHRERAQPAHRKKLGHLEKHQDYVKRARDFHSKEDRIQKLREKASFRNKDEFYFGMIKSKTKKGIHVQSRGNEPLPTDLVKALKTQDATYIRMQATMEQGRVRKLKEELAALVDNALPKNEAPGVNAGQANDDDDMFMDDWDMYDDGPVASTSAGPKRNHVVFTDSIEAVRQADVSSILQKRTTPTALPAAFATDATADSTSKRRKGKGKAALADAEAARAEYEAVSAQIASEAAAHRTKLEQTLAAREERLAQLLRAARELELQRHMMGKGKKEQVVRAKGDKGAQDDDWWMQGVKGAKKSAAEENEGKLPMAGEGVATGARVWKFKTQRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA98</accession>
    <name>A0A2S5BA98_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3231</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="741276.A0A2S5BA98"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="680"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="762"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="302"/>
            <end position="355"/>
        </location>
    </feature>
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            <begin position="363"/>
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    </feature>
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        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="500"/>
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        </location>
    </feature>
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            <begin position="762"/>
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        </location>
    </feature>
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        <location>
            <begin position="843"/>
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        </location>
    </feature>
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        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="948" mass="101735" checksum="D815F14A4F1A1F51" modified="2018-07-18" version="1">MVKREENEDNICHWEECLLQYDTADDLFNHICTAHIGRKSAGTLSLECKWTGCRAKASKRDHLTSHCRVHVALKPHVCSICTKAFKRPQDLKKHEKIHTEEHQAQHQRVSKAAAAGMNGNPPAGKLGAQARTSTHQGATASTAPSMPQLPAQYPFSFPAFGFGYPGLAQANGQPQQAHHHPQAPPQHANSGPQHHQQQQQQHQQQPGVGQPQFPVAGANADQLAQFIALQQQLNSQAQMAAATGLSLPSQAIPGLQANLTNAFAMQLNQMLGGQAMQYLQGVPMMYPYGNFGYGAGGAPLPQQQQQQHQQVNGSHGPVSSGMPMPGMPLMSQPSSQPQGPSSLYPSLPPSLYGSSLPPPVPAVSTQQQQYHSPSVPPMHHAVKPEEHPSPASSSRSRDSGSYSSSLSPRNLPALSPASSLTPEHSFSPTPGPEQQLRKLHSDNQVVGKKRGFEEATGQLLNNLSNKRFQDQDAVNAQLDSLSTFLLTPDTQHHSLPPYGHSADYNNNDDSASSSGSEHGSTGPRFEHEDVDAINQLLLSLNQSLDSEIATSAPQLGDYHLMPGPTSHSAPSAAASYAAHAPMGASLYPSLPAGLSFPSMYGQPGMPNAYDPSSMSHHAKSVPAPSLAHDYRPTQYHHVTRLQRAAPSSSAPPQIEPGMEIDDDVKDAAEALLLAGSINRAHSVPSSKPSLPSLSTTIGSPVDERVRLPPIARTTGASSRLPPIRDLLSLRPSEIVESPTSPVASTSSASSTSATPPLYPSLSSLASSSTSRPVSAGGVERLTHRVHKLRLPSTSSSGDEPTGSFREDDADLSASSGEEDEDRPTLFKKSRVESPIALSPSAESSDRESATPEPSAVKKEEEDDDDELVEAKAEPDEPVVDEEDELARQEREAHIKTLARRKAVIAYLAIYVNHKYREQLARKSMAQVRKAIKKPSPLSQESQLVKVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAD5</accession>
    <name>A0A2S5BAD5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2530203at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="502"/>
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        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="178"/>
            <end position="194"/>
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        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
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        </location>
    </feature>
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            <begin position="503"/>
            <end position="519"/>
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        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="552" mass="60526" checksum="739464065960A909" modified="2018-07-18" version="1">MPPHSALYDPALAAFDFRTLLPGLWRAGEFDKDVEAEAWSDNETVKGSSGPAAPPTTSRSPVRRATGPLPPPPSSSGRPRVAQVGAVGAGLGMARAKKRSNAGNKDKVTSSKKSTAHARTVPENRVDSSTAAAASSPLVERADVGRPNVAADSPYPSVFFNDDLSAAPLYPPPLRRTPPRELPRVELEHSHREPVGGGMPESPYSSSDELRIEHAYPDSSGMPIPMADDDEHWDAYRTQSAPPHRMVEWNDEEDGYADDDSDDFTSSSGYSADESPYSEDEERSSSTGQDEPRPFPNPRLKTQQKYLRPPEHDLEHPPASRTYQEQQQQHGPHKPASYLLSHPTYSPPTQAAVTAYPYVPSLPASALSHLSPYASPLMSPTATTPHEVRVEAVPSNLPSPTSEHAPHYDPAAFDEHAAAVAGQYYAAPVYEDVRGRNPHPRLLWRSVIDRDALEILDAHHERVRGGPLPRLALAQHEAAEQLPAVPQPLDQDAQPVQLGASGLEREREHTGVGDDEMKERVRRARGRRNDPNRRTWSQAGRQWSRQIEKCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAE3</accession>
    <name>A0A2S5BAE3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAE3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="114" mass="12975" checksum="A8279CA261A58412" modified="2018-07-18" version="1">MVCEHTRGENRKPTTGIQIRLHPRLYPPIAEMSLSTQGSLIWSYEFEEEEEEEDELAHPRQAFEADGLVELVDEMIEFLASWRDCAVESGDVVGLQQLARTLVDADFARVAQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAJ9</accession>
    <name>A0A2S5BAJ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAJ9"/>
    <dbReference type="OrthoDB" id="10277134at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40739" checksum="AF20AA14DE2F7D9F" modified="2018-07-18" version="1">MLDRLPTELVSLIINDIPAPPSIWRRKALLDSLGLVCKSWRLAVSALANEILQVDRASAVADIRKWPAARRKQVTTLLLGSEAGTPLQCDEGFSTTVMSRLLPALPCLEHVYFRNIVLESIRVDFEVGAGNPYKKLRSLSLRTSQVALRATVDSVTFALRRLHLETKDPRDGGGFRCAIERLLRSECLPHLELLRLSVRSEWLPDLAIGFFGSLRAFQVDLGDSALTALLNSHADHAVFKTDTPTLFNFERGIGEWPLAADAIVKYIQTTIDDAIGSRSAPSNRLIAIFCLADPEVDRLNYLQRHRAFRPDPCFSCGGYWCGGALTGRYRDGAPRVKIVHACPPQYEFVQPEFLNFLRDAERNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAQ3</accession>
    <name>A0A2S5BAQ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAQ3"/>
    <dbReference type="STRING" id="741276.A0A2S5BAQ3"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="357"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="707"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="437"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="897"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="897"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="946"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1012" mass="109421" checksum="04AAE64DDB6225EC" modified="2018-07-18" version="1">MSGTGEYLTLRSRAIRAREATLESVRVARHQQLAELFVAVRDKPRYTEFEAGLSGRKRRRLVDGKHSQDVEPPLEGLEAFEKEYAKPDSLARLDVSLPPHVVDAKSGSTQPGDSNAPPPPLLADSLANPVAIVEDSEEDAEGEADDEIPPAASAVAQYAADAASSAPSLAPAGAPSAPQIALTAPSASPSAAPSPRASSANATPQPTTVSPAALMTAGPSNPAPTPAVADFPHAPLSIPTYESEFGIHEVSSDYIEALPPVPADTLRTRFNSAASLRASTKKAARSSAVQQVQPDLYKLHVRAQLMSAKFFLGPGKRVHNVLSTSQWETGIDEMRAIRAFERIEELKADKKWSFRQPKKQRTGNVPKAHWDHVLDEMRWMHTDFRQETRWKRVSAYNLASACRAYVRAPLAERSAHTVRCRPPRQLSDEELARKLAGVQDGMEVEEEGDATLEESQSDAPQPRKADIDPSMTSEAPKAGASATADRPVVPIASAPEGAGKAGGSTGSEATPTTSQSSQASRTLAEASRANAQAQHVSKSMAFRNPVFDMTPVETVIDPLALAAAFDEAGTASEDTAVFLQRGLNELFPELPLYSDFIIANDATLARRAEDSSAWSGRLAHVTRLLETKPTLVSTLQPGRTRTSTGWSPALVDALEDSKEPFEGREAVPHTASTLFSARKPKDAAVGELLVKPQEVPNAEIRASTILWLPEEDALLLNLQRQYGLNWSLIAQVFNASTNRPESDYRLAWDVYDRWDKLVGPGSKKLLPDGTEIVRPPPEWLPPVDRTGRPMPIIADGSKKKIRHAIIADAMKKVGKKRELYAAKQPATGFPRRINMAMHESHNIPPRPNWTPMEWTLYKAEQEAQKLRLRQQQQAQAQAAATMRQQQQAQQAQQQQQQQQQQQSLAGLQQSRPPSSLPPQMAAQQAAAAAHASPTNSTAALPGSPSAAHNQIGSSQSPRNAPQQPNGHVSGQMPQLTADQLAALQARQRELLQAQAQAIAAQRAAAQQQASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAS9</accession>
    <name>A0A2S5BAS9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAS9"/>
    <dbReference type="STRING" id="741276.A0A2S5BAS9"/>
    <dbReference type="OrthoDB" id="1612078at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015733480" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="3">
        <location>
            <begin position="80"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="3">
        <location>
            <begin position="263"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="581" mass="63957" checksum="B0069DD659CC0DC5" modified="2018-07-18" version="1">MLLSWLPVTLSVALVTADKAQRPFVALGAGSSPTSAEPHADRLSRPLWRLEEPLDLPETTAYGSGGMDTAPRENLQVHHPVLVPQNGKRCTVQLVRHDFANSYYQPAIVDYKPPRDCPSNDWAAVVLNLTVTSNGTQFDRLASLSLSHVEIWRTSTAEPTKAGIIWTYEKDVTRFSPLFAQPGQILLELNNIVNEQYTGIFSVQLSATFYAATPAFPAARKADLILPLTTGKRRSSQMLSYPGDTRRALEPPMNTAEANFFPEAGLIGKGPYREVQVRIDETLVGVVQPFPVIYTGGANPLLWRPLASLRAFDIPSGYLDLTPFLPILGDGGKHEVLFSVLGEGEDNTVNENWFITGAVHVVLDKAHPPLRTTGRILDYHFAPAPLIISAGFPSPDRTGLKTSVGVSRGFAIRSEVETGSGGKKIVSVVMNSKFDNVQDFEDKGLSQRVRQTIEYSYRSTHDGRVRLQDAAEFPLDIATNYTLLAKEHRFSAKLRSYGYNRQLLLPAALCDSHCGKDGSSAATKSSQSGEAEITGRDGQRSTGWGRMEERYSFVDSAGLVYREHVKAENGTVTKRNRSRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAY2</accession>
    <name>A0A2S5BAY2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAY2"/>
    <dbReference type="STRING" id="741276.A0A2S5BAY2"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="105" mass="11246" checksum="C6FF7F939B8F88DC" modified="2018-07-18" version="1">MQAQLDALKQSLEGKIDFVGQDLVEERAKWILWAAAAISFVVGLAVQSIKVTLGLFAVGFVACLAITLPPLPAYTAHPVKWLPTLDQYGEAVPSDTAPVGAKKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAZ2</accession>
    <name>A0A2S5BAZ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trm112p-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000031">
        <property type="protein sequence ID" value="POY73949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAZ2"/>
    <dbReference type="STRING" id="741276.A0A2S5BAZ2"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14901" checksum="815146DEE10F184E" modified="2018-07-18" version="1">MVRLITQNLLSCPSRACAYPTNFPLSFRNVEKLEMVDAEFNEEFMRGVLSRIEWQALRKSAAELGNTDLPEQGPDIAQPEAVSLDLLKTLHHVLLEIVVADGEMVCPQCEHIYRIKDSIPNMLLAEHEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBJ4</accession>
    <name>A0A2S5BBJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBJ4"/>
    <dbReference type="OrthoDB" id="10587302at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="472" mass="49910" checksum="FB09A37C962578FF" modified="2018-07-18" version="1">MPSSPKESAAAATDPREPARAPEDRSDDETDDDDDEDGEVSPLESSEELLAPESLAPSSLSTVRSRLFASDDEDDYGDILEDDGILSMSGGDSCGSAFSPGSLLSLASPARRAVLSIEAATSDPLRHSLSSPPTLEFDHVRQRGHWIPARSAPTSETVWNAPDVPDVVVRPATPSVPTSPSTTPPSSPPRGATTPSGRPESLLSKSLRSLARLPNLTLADVLPRAAVPVPEEDLTALPPGWGPAERRRVLAAEPSHAADEARAGFRYLLRRPPSPFSAGRRLAAAAVASGSRKSVEFGHPIDEVEALGYGFGFGLQDLGCAASPAALAPDAGSGDEEDNLAQLRARAPTSPSADVPPLPPRALERPRSKESSPPADPVPAPSSIPVTDDDESPVEASAPLSPPPSLPPRFISNHRHLLMLSLEFEMMRHAKIRGPLRQRAVIVRQATSPPRERGVTRERSRLSQEVNLVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBN5</accession>
    <name>A0A2S5BBN5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBN5"/>
    <dbReference type="STRING" id="741276.A0A2S5BBN5"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="33"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="532" mass="58850" checksum="7AF1E5F350B9C25F" modified="2018-07-18" version="1">MMLAAAKKGVTALMEGNIGEKPRSSISALIDILCTERYDEDSLDGIAEIVDSINLQPTTGSTEASRAIRKKLKYSNVHGQLRALTILKVLVENCGPRFESTFADERLVERIKVIAGDPHTDERVKKKNMMVLRSWYIQFKDDPRMKLVAGLYKQCGGNVAGGASKQPARSDATAAWEAQQERYEREAAARAERKAAERRAREAEQERVMQEKLEKARRKEAERARAAGGKTKRPKFNFELEKPKIMAAVGTGTQAAQALVNALQHVNREKESVVTNARVQECLEKAKLTRKQLIRYIQLIDQDVNGDYIGTLIATNEQIIAAVQMYDRMSKPVELDSDDEAVEQAKRLAQQQGLSMPASATPSHGHHGANDDTQSIRSALSNFDMQDREVDKLQMQQRRRLQRHISSRGAGQPVHPDLQDLAFGPSGSSTLPPPIQPHSAEDTYRHGSLSDFSDYSSSEGEDVGPSPGSRDTHGATPARSYAAYVREEDHRAAAAEDPFADPFADSNEAGGGGQYQILTPGISDKRMEWKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBZ7</accession>
    <name>A0A2S5BBZ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBZ7"/>
    <dbReference type="STRING" id="741276.A0A2S5BBZ7"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="910" mass="100140" checksum="6420DCF2026AC501" modified="2018-07-18" version="1">MANEGHSHRAHQKQSNKPFKSKHASKSQLKDQAKGRTHRPAVKDAASKSERQQSQKVQAKNLKVNRRNHAKQVLDKKRQIVEDQKGIFTGKNRNGDRVQRIVAIVPMTDDVDALETAQLLAQAVGGQLTGEGAQRSLEVPKFHNQSLRFLLLPSASQAPSLFPIIDTVSAADFTIIALSSESEVDEQGETVLRCLTGLGVGGANGGVLGVVKDLPGGNASLASTTRASLHSFLTHFFPSIERIHCVSATPSASSASTSAMATDSSAEPQPSSEATLIIRALCEKTPKGMRWREKRPRVLAERVGWEKNAAAAAAAVEGGQENGGEDRPSGFEGEDLGTFVVEGVVRGNRLSANRLMHVQGWGDFKVSKILLAPSVRQQKRSHAESMTLDGGDSATTAPFEPISVPDDDADSLASTNVPDEDDFGMDEQTWPTEEELASAPAALRERGEMPPPARPGTTPKLKKVAKGTSAYQAAWIIDEEVGELSADEAGDDSDEEAMKDGEHDEAEGDDDEEETEFIDTLADETASVSARPFADLSPEQEQAQLQEYLSQRAARRNVENQDDLDFPDEVDTPLHIPARERFARYRGLKSFRTSKWDPYEELPRDYGRCFMLEDWKGMGRRMEKRVAEEGVEPGTRVIIHLENVPRRLAEERNPLYALTLFGLFKHEHKYSIMHFTVQRNTENSDAVRSKDPLVLQQGFRRFAINPIFSQHTMRNGGKGANNVHKFERYLRHGINASVATAYLPITFGNSPSLLLRVPTTSPDAEDASPDQHIHLIGTGALLSSDPTRITAKRIILTGHPFKVHKKTATIRYLFFNRADVEYFKPVQLRTKGGRIGHIREPLGTHGYFKAGFDGPISQLDTVCLTLYKRCYPPNFGKVWDGQPLPVVSKERVQAAAAAAATAQADEVEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC04</accession>
    <name>A0A2S5BC04_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC04"/>
    <dbReference type="STRING" id="741276.A0A2S5BC04"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015403761" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="378"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="548"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="659"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="800" mass="83863" checksum="8E908C83A304E6EC" modified="2018-07-18" version="1">MHAFPLVATAFLAALSSVDAFWRLPCQNVLTVERADPIVTPGQVAPHVHNVVGGSNFNLGVDFDTLRQSECTSCLVKQDLSAYWTPQLYFQWANGSFSSVQWVGAGLLIYYLQRNNPADTTKVTAFPDGFRMLTGDPFRRSYEDSLTSEAIGWNCLGAPVSETRQPYLPPYNCPNGLRGEIRFPSCWDGVNLDASDHFSHMAYPLVNEAGPCPASHPVRLVTLFFEMMYDVNSWKDLWPQAKNTSQPFVLAMGDPTGYGWHGDFLNAWDHDVLQEAIDTCTSDSGVIQECDVFDLYDSSATCHRTPDVDENVLGLLPSLPGCNPVVGFGPEAGRCTSPTTPKVLTGVPYTGGAPPAGTVVAPDQPSVLLSYVSKAGQNWTYVDCYSDLVPGRALPNGLSNPAQTVEGCLEACNGKGYAFCGVEYHGECWGANTLNSASQALGAGACGLTCSGNPLEYCGGVGGPTGAAFSIYVPKNLTTPTTSPNATTSALSTNATSSPLASSTVLSTVSSTVSSAISTAVSATSTVVSSAPSATASAASTKVLNNPDWTYKGCWSDLVSSRSLPVGITGSSNFTIEGCLAAAAAGGYAVAGLSYYGECWAAAGLSYYSTQLDASKCTYKCRNNAAETCGGSDALDVYDSTVIKLVQGATNADLATFGAWKYDACYQDNVNGQRSLPTQLTNSNNTIEACLDACSQAGAQVCGLEYYGQCFMSKTDISASASLLPDTSCRFACSGNPNSMCGGNAALGVWRLQSSTTQAAAPPSGQAFSGTDSARIGLAALPVAKRMAFVKKGSAAAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC12</accession>
    <name>A0A2S5BC12_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC12"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015623410" description="T-cell immunomodulatory protein TIP C2 domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="10">
        <location>
            <begin position="598"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="751" mass="81351" checksum="9FE2B78B9510FD8E" modified="2018-07-18" version="1">MVVVCAWSALLALAYVVSSSSSSSATATATATVTATGWSLFPSAHGGNGTRFVEERLIDAGPLGLPVHSGLVAAWVDWNADQHLDAVWLSSDQSTLSIYQWDHSRYAFHLAGQPVTIPQLDRGRDDAVVVNVVPGDYDFDGRVDLLVMVTTSTGGGWWGHGDPGDGTVRLLVYLQQPDGSLGKPVVLDDAATAGLHPIPIDANGDMRTDLLGYVAGPHPDDPPQLKLWRNIASTDPSRLFELQVERHDRSDPPLDLSSHPSGRFTCHPPPAPHFDAFIDLDGDCLADLFLTCLDDPRRSESSGASYQVWTNDKDKGTFVFKREGRLPKGVKGITFADMDRDGTIDLVVTSCPNARTPTTGCHLSILYNNQIPLCDSTIPSSQLCRDPEALCTADPDFRFSAAPGDDHEEATFDVVVEDLMAAAGGDGDSKKTTARHLVTSSNAGFKGAPFPVVPQIGDFNIDGYPDLLLITTLASGGGGGDKRASIFESVPCAKGVSGCTDADVKNKRRGFRVVRGKGAEALDLIRDVESASWVDLDDDGTLDILVQRSANSGAARNAAFVKNNYFRDAFFLKAQVLNGACQGWCEPRPGTDEKRYRPFGSSYSGASFKFTVLDPTGARRSTQYAQLPQTSYMSLAPPYSYCGLGRTNNYLENLFVGSTRHQPRHYVNIEGLIPNSQVLINPFQPEGSDDPASWTKMLYLRPGDWIPWVTVVLLAAIVALGIVVVVLHVREKRQDEAERRARLLSLNFQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCA1</accession>
    <name>A0A2S5BCA1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Insulysin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2582</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCA1"/>
    <dbReference type="STRING" id="741276.A0A2S5BCA1"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="96"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="260"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="444"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="829"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1088" mass="120541" checksum="5568F748708D0CAA" modified="2018-07-18" version="1">MLLGLALRQHSRQGFAAAGRSALGHTARRPLVPRRPIVAARRRLNGGTTMAQATPIETWSPQLATGSRLLREPLEVSPNDSRQYRLLKLANGLKALLISDARTDKAAAALGVQVGHLSDPDDLPGLAHFCEHMLFLGTERFPDEAEYKTYLSRNSGSSNAYTSLAETVYHFDVAPAGLPGALARHAQFFTRPLFAESCTEREVHAVDSEFRRNLQLDARRLFQLGKSTSSRSNGAVYHKFGTGSKVTLWTKPLQAGQDVRARLIEWYRAHYSANLMNLVVLSSHSLDELALLVEQEYGDVPTADRTRPRFPAPPITKEEGGREISYRTVKDSPQLRIEFGLPGLSHLSGTKPANFVSHYVGHEGPGSILAELKLRGWATSLSSSASGGANGFDFFRIGINLTRDGLDNYRQVVALALGYVELLKSTDPQEWSFAETQQLGQLAWRWKENGQPRNTVQNLASALCDETYPLPRILSGPYYATKWDPTAVREVLDALSISRCRVFVGSKDPLPGRAFWPSAEEYYGTEYDTTLLDVVAPPADAKLSLPAPNVFVPTELKLLCQQPVSTPTTEPDLLRNKPSRHVFHKGDDTWCIPRGNAYLLIKASRADATPRDAMLTQLFTSLVEEELASISYDATLAGLHYSLGTERAGILLAVSGYTDKLPLLARIVMAKMRTLKLDGEEFSVVHDRLSRAYANAKLANPYSLADIELKRFTRSTFWTYEERFEALQQITREDVLRHAETVLQHAELDVLVHGNFAPEDATNLVRVYDEVLGAAPTNNAQLDHHRGLLLPEGEFGSPRQGLTPANTAASVLYQVGSAADDQLVSRLSLFAQIAKVPVFSTLRTKEQLGYIVSSGVMTHDAVTGFRVVVQSEKSPEYLDERIESLWTGFGQYLADLSDEAFDKEKASLVNLKLEQPKNLAQESSRYFEQIRTGAYDFGARVRRAGIIRNLTKEDLTAFFERYISPASDRRAKLAVLFRSQRFQPDALRDLVADVGRLEPDRRDDVQALAEQKPTLSQIEAFVAGLGHTAREQLASQLSALRTSPPLPTGSKEIESDQVAVDAFRRALPLAEPYRPKLGSSSPTEQPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCE6</accession>
    <name>A0A2S5BCE6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCE6"/>
    <dbReference type="STRING" id="741276.A0A2S5BCE6"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="61"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001467-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="158" mass="17261" checksum="89ACAB8177155658" modified="2018-07-18" version="1">MTKAVIFETSMGQVTFELYDKHAPKTCRNFVELANRGYYNGTVFHRIIADFMIQGGDPTGTGRGGTSIYGDRFEDEISPELRFTGAGILAMANSGPNTNGSQFFITLAPTPHLDKKHTIFGRVSAGMQVVQRLGAVATDGDDRPRESIKIMKARVADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCL1</accession>
    <name>A0A2S5BCL1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCL1"/>
    <dbReference type="OrthoDB" id="2527198at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="236" mass="24852" checksum="1F71724E2B13C71C" modified="2018-07-18" version="1">MSVGDPSLFKFLAGASCGMAGVMTGALLALPLVVMPALFASPTGTPRSRLHVWSRLEMETARLIGSAMPVLTAMLALCALLVRSAPPSQGRFLFVLATILILAIRPYTFGLLAPRVDALKAEERRLLVQDVTRETALGAATGASGWRGATPTEEVADEETEVWQNDVGKKLSHESGLTRGSAAATIAPGLASEPDLPCETPVNTDRAILELTRLHSGVILLCGATFACILAELLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCL9</accession>
    <name>A0A2S5BCL9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2272</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BCL9"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="462"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="836"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="11">
        <location>
            <begin position="1037"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="1466"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="1650"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1958"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1968"/>
            <end position="1981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1981" mass="217505" checksum="4C60930027E8737A" modified="2018-07-18" version="1">MSTTSNGMNPQAVPVSAPDPTQVASQRLTTPSGRHSHALGGPKPKKRCNKKPYSADDSQGGNRGGRVILPASSASAGSGAAGPSTAGGPVPKQPRARKKLKNGRKSVPSEGRATKQGGPAKSSHDKRTAAPPQQQDDFVAVATRTGETAFTRPRGDALNSSIASVLGRRPAELLEEHERELRTKRQKTAADALRSAMLAASDDEDEELPGPLLEDRAAYASKGEVFGEILEHAETRPPAQGLASAAAPDRDMTDADDEAEGLLIVEAAEHFSAAEAGPRTEDAAVRQELSSHAPPLPGTVESGGQRDHVISVPARPGPARASTNVAPKGSTTSAVEVNQSSRAGPAAAFSDLPKALPVLHGAQPKLTSAASILAGKRRKKKPLKLKRAPQLFDYLSDEMSDDWEPKADKYKAPKRPKNGRAIDGRLEIADEDPKDGQERPASGSVAADERIKLVPTSYQAALLERAKASNILTVLSTGAGKTLVAVLLIEYLHAQEALRLAGTTGTKRRMVFFLTNSVPLVHQQAYVLARNTSLRVGKLFGALGVNLCSPTEWAYNLETYDCLVVTSQLLLDSLAHGFLRMEQILLLVFDEAHHAKSHNPFASILRDFYHRAPIHQRPRILGLTASPIDSTQGLREAKKLEALLDAKLVTAPAETQADLRSMVARPTVVSLNYDPAPAYNVTDLHAEILDKVVIHDDAFVRCLASAESVLRVLGPDAADLVWHLALRRYKAKLLPHVPESSDEEDVGDEDALQARMVDAGLDEPTKPIIETGREARKLSRAEEKRAEIKREKVRMKRELREKALAQVQLDLPDWLKIIEQHKPTLEYERLSPKLQRLLDLLKVCKSGSDDFRGIVFVERRVDALVISEILKVFAKVEDELDWLRVECVTGHGIGRRSAMDPRMPWHRQASTLASFAAGNFNLLIATAVCEEGMDIQPCNFIVRFDLYQRHISMIQSKGRARAPGSHYVLFCEQGNVEEKRKLAEIARFDEDMAGLFEDDLETSSAVDEEQDFYGLADERCTYYTEPATGATITPHSALSLLQRYAASLPRSDEFSVGRPEYTVNDFGVDEFGERQFSCTVLLPSASKVRVVTGPLCPNSRVAKREAAFCAVKVLRNVGSLDAHLLPLRTLPPEEAKDPESGEAVGSKSRQVEYTRKVPRVFVPRQTCEEVTTLFVTAVHYGGPEGEMTRDGQLYRPLLLLTRNELPDLPALVLYLGGEAINMYATKIGRVESTSTQRAALTSFQVELWQSILNKRVRVGRRAQADGGPQKLDLVYYIALPKVKGWSPTLLGTNAADALDWLAMSRAVSEKERPIDWKNLTGLEDSMIIDKAKNGCRYFFERIMPDLRPHGPLPPGRQSDAGFSSLMDYYLSFNDAYFHAFHVAPDQPLLELSKIPKNVTHLTRTPRNDVAPTTKKLVSKLPRLALPQTCVLHPLPASAYRTALLLPSFLSDLEQRCLVNELNDALFDGQLAHEHLRTALTSPSAAVGGTDYNRLELLGDSILKHLVSTFVYVSQERTTHEGIMHRLRLELVNNRYLFEAGKRHDVPLHLVTKPFTSRHFLPPNLVLPDDKDKPPPNSTVIGDKTIADSVEALIGAAVETGFDRSGLSEAFSLGLMAIKNLGIDIGTVTTLSDFSRLYGPPAEQAAVTSDLREVESVLGYTFGHASLLQEAFTHPSKLDMVSFERAEWLGDSVLDFHVVRYCWARWGGDLGPGHLTELKGGCVSNETLAALAVELNLDRFLIYDHPQLETNMRLYRERVIAAKAKELKEAAEEAREPRPYWLTADPPKAVADIIESLFGAVNIDSSFNPTVPQQVFDKMLAPFFARWISPTKLKIDAIRVLLEAAQAAQCDDVSHVSTNLEARFDPRTGELVQPLTRCSVVAHNMVLATVETANAKTAKRLASSDALTYIQQSQSRHPSSRIAHGPDVATLTDPGFFPSVCDCPRRRAVAKELALEEIERRRQEGLLSEPEDDGSDVEAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCM6</accession>
    <name>A0A2S5BCM6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="6" type="ORF">BMF94_2289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCM6"/>
    <dbReference type="STRING" id="741276.A0A2S5BCM6"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="360" mass="40019" checksum="5368DEE82D1C5721" modified="2018-07-18" version="1">MIGHRAASLATRQSLTRSLSRSAPRFTHPTNPLDPNPTPTPTATPTPTSTATATGTAPRTDSTTHFGFRDVPEQQKENLGETSLLPEIDADSTHSLTHSHPGGTVRGVFSSVASSYDVMNDAMSFGIHRLWKDHYVSKLDPSGGLKCLDVAGGTGDIAMRILDHARTKHGDRETSVAMLDINPEMLQEGKKRFAQTMYHNTPQVSFHLGNAEHLSDFADNTFDQYTIAFGIRNCTHVDRVLKEAHRVLKPGGVFSCLEFSHVENPILANHFASHSHEHCHLLAWYGRAYDLWSFQVIPPLGHILASDRDSYQYLVESIRRFPRAQRFADMIREAGFTVPREEQWEPLTFGVACIHTGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCN0</accession>
    <name>A0A2S5BCN0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BMF94_2273</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCN0"/>
    <dbReference type="STRING" id="741276.A0A2S5BCN0"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 21" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="30"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="550"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="POY74513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="770" mass="83005" checksum="8F93D1272B094078" modified="2018-07-18" version="1">MVSYLRQRQLSVENLTRAATAQTGPRTLYDKVFDNHVVHVSDDGTTIMYIDRHIVHEVTSPQAFEGLSLAGRKVRRLDGTLATVDHNVPTSSRKNYKDSASFIKEADSRLQVLTLEENVRKFGVNFFGMTDKRQGIVHVIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTILQKKSQNMRVQIDGDLAAGVTSKDVMLHVIGQIGTAGGTGSVIEFCGTAVEKMSMEARMSMANMSIEGGARAGMFAPDEITFAYLKGKPLAPKGAEWDQAVGFWKSLRSDEGAHYDKVVKIDAADIPPTVTWGTSPEDTVSIDGTVPDPAKAADEATKGKIERALAYMGLEPNQKIQDIKITNVFIGSCTNSRIEDLRAAATIAKGRKVAEGIVAMVVPGSGLVKEQAEKEGLDRIFTEAGFDWREAGCSMCLGMNPDMLTPGQRCASTSNRNFEGRQGPGGRTHLMSPAMAAAAAIAGHLADARKYQDGQRIAAPVPSVEIAPEEEEVPTTEQPTDAADDGVVESAAAPENGAPVTTAAAGMPKFEVLEGTAAPLERANIDTDLIIPARFLKTIKRTGLGISLFAALRYNDDGSEKPDFVLNQPAYRDSKILVVSGGNFGCGSSREHAPWALLDFGIRAVIASSFADIFNNNMYKNGSLPVVLPEEQIAVLIEDAKAEKPLAVDLPKQVVRRSNGEEFSFDVDQSRKHYLVNGLDEISLTLQREADITAYEKKRSEMCPWLDGKQYRSGKIGVTDGPKKTDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCN2</accession>
    <name>A0A2S5BCN2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCN2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCN2"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="7">
        <location>
            <begin position="185"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="684" mass="74408" checksum="5AFC8A052FCBF636" modified="2018-07-18" version="1">MLLARSARRFVPSRCASPLARMATPPATNGVQAPKRALSKSPTPPQPPAAAAAAAASPATKKVKLTVEDPVSVPPILVETPVEANEAKNDDSSSTVAAAGATAASTTTDSSAASKENAATSEGKANKARKPRQRKGKAPKPGGVEEAGAFDVIELLGAERVEELQRLQEEEGRDWTKEAEQEWGKGPDGKDVEVRVVGSNDHGDGLATLTPSGSDLPTRLVSIPFALPGELVRVHLHRHEPDYYMSHGDLLEILEPSERRKAEVEELPGRVVDDKTAAKLAEVRAKYGNRVQCQYFGECSGCQYQPLAYEEQLEMKRDVVRRAFANFSGLDASLIPDIGPTLASPLQYAYRTKLTPHFQVPPSANSGRNKKKKGKQAVESEAAAAEPKKEWEITIGFEQKGRKRIVDIEECVIATKVINDALVGEREKVKSNIAAYKRGATILLRDTLPPRPTDAVAKATPYVPSEEPHVCITDHHATVREQVGPNEFEQQAGSFFQNNNSILPSLLDYVKDAVGPRPTDGQKRYLVDAYTGSGLFAISLADMFDRIEGVEIDKASIKWAKRNAEYNRAEGRGEVGFRDGKAEEIFKDIEFPADQTTIVIDPPRKGCDDLFLSQLLAFNPATVVYVSCNVRTQARDIGWLVSRSAEAAAQDPSKKAFRIESARAADLFAQTHHAEGVAILRRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD46</accession>
    <name>A0A2S5BD46_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD46"/>
    <dbReference type="STRING" id="741276.A0A2S5BD46"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="8">
        <location>
            <begin position="86"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="382" mass="43548" checksum="973F99AAF217A30D" modified="2018-07-18" version="1">MSFEPAPHAKRQRTTFLDAGKPDLNPAAPVQPDIFSNRRPTHPTPAQSSTSRPRDGQGKKRERSTANGNYLGYYRRRREVQEGENDERLELIPIDWIKGKRVLDVGANAGEVAIELAQRFKASEVIGVDIDPELTHQARKNVDLAWSRQVPLPQLVAEARKLRRHHGEQNGDEDEGDPRSGFKAEEQQSEEIDCDYFPTSMARMFGFLPHPRGLVREYVEQDATSPRRAGRQNQHAVVEIRHFPENIAFETADWVNTPIPADREGYDVIFALSVTKWIHLQGLNPGLLVFFRRCFDSLRSGGRLILEPQPFSSYARNVKAQPELQERYDKLLSGAEKGWRAEDGDFERVLIELVGFGKRELLGETGRVATTFRRPVEVYTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDT2</accession>
    <name>A0A2S5BDT2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDT2"/>
    <dbReference type="STRING" id="741276.A0A2S5BDT2"/>
    <dbReference type="OrthoDB" id="5407957at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="972" mass="104726" checksum="0676770A64657933" modified="2018-07-18" version="1">MPLTTSGRGEIDVEQSAEETTPLLSGRQRDQARPQHRPRSDTRNADVDADAGPTLRRPAPYAASSASDRAKPSAGATSGVLSRWTRALAALRTGHLPSSEQFVKLCDTMLESDTLAVEPRGTVWQGPDLGRGRIGTGRLSEKGERVRLATRRAALAHRDLLARRNRDLPTGTAPGDAWQELWYAWKQGELATAESPSPEETSDVATEADHDPPTQSVRSALLTLVRLIVTSASLRQLVADLVLLLRDLVQLQLGQRDLQPAVKEKLEQAVETVVERTVGQDRVQEHDLAAEVQQARPTTSLHQASSMDTRDGQRPVLLPEQDADDLRGRILDRLRQIIAELQRTKAYQQAMECLLAALRTRLFSLLDKSDPSATALATAAADSHPSGQNPLGVGVLLVRPFVEDADPELARALGDWADRLRTALGGPEAVEARCGAPDAGAPTPPFESMKAFVGQADEFITSILLKPHYLGSNESYRALGVLTETVEGFERDAPVWVSDVRRLVREAISSLLCVANDPILGEAVAASAEIVEASGAWLGTAGLMVGKAASGGILGIGEAVWGDVVEWIVPRVLGVLSEASLPRLEFAMPNVAVALEPPSVISTSFIPARISLHQSSLLSYTPPSSLATLAVPLSASVPAAAENPDSCTHFKTTNVLSVEGIQLEVLNVGYFASYKTGIPCFGDVTERGLLDLHFGVDDDATTTDPSLNAAEGLAFDLTFHTPTSTSSDDDDPPLFQVDHSRTSVRLRDFRLEPHQSSHPWLMWFFRPLLRKAVQTVIEHELKEKVIEGGAEWIARIGGEVRGRRTVIEAEEESTTSGMWSWVRSIWDVLGSSGRTDRGQEDGSPAQQQLRQVASPSSDAASEASAVHVHLTSQGITVDLDDFEATVGLGSKGVVLPAGEAEVPLPEGEQPKKGVARAARDEVEREVRQGKAAARAGMGMIGSAVEARQQWREEVARDGLAGQTGWRSDAFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDV6</accession>
    <name>A0A2S5BDV6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDV6"/>
    <dbReference type="OrthoDB" id="2538370at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="172" mass="18474" checksum="A5D2FD89AE6F6923" modified="2018-07-18" version="1">MGRSAKMMKRPTKAVSRQINKPAEPVRRVERSLSPEAGPSTIPLFNTSVPGRQSLKPDPKSRARGGAASTRGNAKDVMDDDEDGAEEGMMDDDDDQDEGADSVSVALGEGNKKKKGGLRDKVKAAKTAMKEDDAKSAAKIAGNRRKGPKSNVLGSVDYVKLHEARPGKKKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDX7</accession>
    <name>A0A2S5BDX7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_1946</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDX7"/>
    <dbReference type="STRING" id="741276.A0A2S5BDX7"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="259"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="392"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY74970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="434" mass="45558" checksum="38D8C20F24FB69DD" modified="2018-07-18" version="1">MSTGGRSGRGSTLSVSPSRSPARYNRTRVPLQGQYLLPGTVHRQPCSVCRVTRRHHPNPSFAPDSLRLALSGACYTDHLAHCQGSVATQTLSPSSMVNTRSQRIPLSSLSALTLHSNRRTASRRLPAVPQLACTGSLCREFTPDVVQCVAVGSDGVGGLEWKCEADLPSGLRFGEVDVSCEGWDGPNDPNILRGSCGLRYSLVKASPSFEQGYDSYKSYLPGRSSSLFNDAFNLLFSALTIYLVGSLVWKILRPCFGRRRPAPPTQPRSPPRTWPWWNGWGGGGPGSGGAGGPGSGNSGPPPPYTPKANSDTSTGTGTGWRPGFWTGAAAGWIANAFLGTGAGAAERRRNLYGVRGGGGVGYEGEDAALRRGGFWGGGAQPPLGGTRGWGGWGGAPAGPMGGMRRGFARDDDDDRGVGTSGMRRSTGFGGTSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDZ0</accession>
    <name>A0A2S5BDZ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDZ0"/>
    <dbReference type="STRING" id="741276.A0A2S5BDZ0"/>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="152" mass="16307" checksum="3B901B71ADFA04DD" modified="2018-07-18" version="1">MVRFKHRYLLVHLVFPDQLELPSSSTSSSAAAQPATPASTLPQATLTESGLINLLRDSLSVNFGDVGAGEVGGTFSIKYFSSATSTVIIRVSREHYRTLWAALTLLRKVGGHECIARVVHVSGEKAVPFKEIAAMSLALREADGAPLSCFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDZ3</accession>
    <name>A0A2S5BDZ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_1965</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDZ3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDZ3"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="14">
        <location>
            <begin position="41"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="229"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY74989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="333" mass="36214" checksum="EB7D46703911B18E" modified="2018-07-18" version="1">MLATTLSQAARRTGHVRLSSVLSLARSLSTSSPHMKQIERLTVVGAGLMGAGIAQVAADAGVKVVMTDVSDQALENGRSIITKSLTRIARKKSPDDTAAQKEYIDRVFSNIATTTSAQEAASFPDLIIEAIVENLKTKQDLFRRLDEIAPRDTIFASNTSSLSVRKIAEPVSDARKERFCALHFFSPVPQMRLVEIISTDKTAPGVLEDVVEVCKRMKKTPVRCGDTPGFIVNRLLVPYLLEAVRMVERGEATPEDIDAAMKLGAGVPMGPLELADFVGLDTLSHIARGWREERVSTGEIDAKQVEEVSALEKLVKEGNLGRKSGKGFFDYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDZ5</accession>
    <name>A0A2S5BDZ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDZ5"/>
    <dbReference type="STRING" id="741276.A0A2S5BDZ5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="229" mass="25418" checksum="8D78089F8E5BF701" modified="2018-07-18" version="1">MEQLYADSLRATQPTQLASVSFPGSRRKTPPTGAWLGFGRPAPADPGPALFLTPLSAADGREIQPANSPYVYRVANLAGLWQFKGLHPDIDSALDIIWQAAPDPWTATVPAAMTLPHHPDYNGLAKCPWWLEPSPDEMSLAQVRSELTLGNASLLDDVRGLAKSDRNEIIAWIEQLSSEEVYKRLDKQLDQIEANAKAESKAPLAQAVGYWDVDRLRWLRQWFAGMEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDZ6</accession>
    <name>A0A2S5BDZ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein MON2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BDZ6"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="280"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1207"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1267"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1582"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="847"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="940"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1881"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1999"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2185"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1888"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1999"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2186"/>
            <end position="2197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="2218"/>
            <end position="2233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2250"/>
            <end position="2265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2265" mass="243407" checksum="664B8CF605138B84" modified="2018-07-18" version="1">MASTALLAADYAALSREAGRRHSDVRDAADAAHNLLKQSSQQSMLELHADPPPTSHPLYQPIFLAANTKNAKVIALAMSALQRLIMANAVPRTFVQQILDTLDHVISQGVEIQLKMLQILVSLLTTDEPVPNSKGRKRVLVQGEDLARPPAELEVDVNLDTQALELSHRLSTSKIPVVASTASATLRQLFMFVFERVGAEDALIAASADPNRDPVLPKADFNVDVPPNEVDRAQVAPEDQSTGTGEQSQHGTGEEDSLAAGQRQQHERARSRSIKLRPAARDAYLLLEDLCLLVAGSVEGGPDGEPSFLRWRSLSRTFGLELVESIVSGFGEIVRTHPELLLVLRAHLCPLLIRFLSSPPQSTLTSSTTFAYSFPLTLRLTRVVFLLLKQFSDLLTLEAEIFLTMFVRIVGPGDRGEGEGGHPAGPAAAGQNSPLWMRVLALEIFRGLCSDFPLMIKFYQRYDAATREAEQRTKDVKGKGKAADGGSTFFGDLVTALNRLASEKPAALGTGSAVLYGSSQGPIASGAVHGTGSSQTVSHTSSTTGMTGSTVIDSAMGMGLGLAQVAGSVVGSGVAAAAGAVSTAVAPVPSLSLESASMKLQCIDQLDKAEPPTIPDTYLFLLSLQCLTALADGFAGYALHAYSKLVPRQAKDQGSAPPALDFAILDRRDPTVASMLVVRAMAESAWPALLASMSFFIGTSLSDDLFSDVVMSIQNFTSVLGILDLETPREAFLTSLCRFAMPPAIVSYITSHADSVQASQQTRSGGAVAAATAVLSAGAESLALLTGAGSSAAPVGLSSRNLACLRALLSVAHFLAGSLGLSWFSVFETLQNADVVLRATATGRGARKRAATPATSAANAKSASAGQTGGSNSSGAVTTSIPVIPTEEDELAIQQAIADMFSISQALGDAAFRKFVGALCRLSGEMVGVSMHQDGTLVLDDGADDQSEAGSAGTVTPHHETPERLKRRSSGMHTARGHSSAKQGKEKSFALAKLGVVAGHNMTRLISQPPEVGWDLITSHCLYLLHESTVPPTIRVQSTEVLTHTLLGALKALAGAGASDVDRQARVQQLVFSALAELAEPPRRLQTATDLEIRRMALETLLRILETSGHALVTGWDRIFHILRTACPSGHSFLPPIPSPSIAGRFSLDTISERESLAPTTPVRASSSTGGYFMQPPTQASAETSARVLKGAALVRTSFPSLQLICTDFLDALAIDELRDCVATLADFGAQGEDVNVALTAGGLLWNVSDHVQAKQRDGDSPAAHGDLWMYLLQSMLAHCRDPRQEVRDAAIANVYRSLSVYGSTLDASTWESCCWEIVFPLLDDLTTTIRQHDGMSDEELDEQQTVPQANGPPLRLIDKQWDDSKSLALRSTGEVFFDNLALLAQTERYEAIWDGLLQRFQDSFCTDRAGPTTAAMQAFEKVLTVALDTSNADRITSSWERAWQAWDAIGAELELNEQDVENAQAKAYTQANLEVFVRVALSIYTPPYIHFDLDRVRRLLAMLKAALLYSHSPDYRLDIDGLMPLQAVVLEVVAAIKLGDLGGAPAAVITELADYATLAYTSSFEAPQYGTFGKAGQRVTYIALAKEVMPHIHYLLNKYRDDVAVYMEGAVERVLDAYALPMTLKHDCPAPAKFGSAEPLWKTATVCFLKAVRATLSSMHMMETLSAELRSAIWQRIIEGLAGALHSSVTQGSPVATYDDLRREENFDLALLITLEQEVLPYVGASFVPDDLIRQLAKALQEASRLYTLDLPRADQDDFQDSLSAAEPRFDSDFDRQARTRLEGTTVQTVEVQKERLAYWSLDTLFLLCDQQHADVDDSRRRVAGLCAPSLLARCAAVFRAYVADAPLRGKMPFPRIRQEEVLYLLQRLHSLRLPPSTLISVDPTHETSNGANAQSPSSNVRSTLLSSPRALLYELYPLLVDLFRIVATLPTVARAPEHLPRRFHSAGDGDDALFDGLPNGWEVGQIGRLTPPDAGHDLVTLIGACLGQVGEEMAAGLSLSPPSSALTSAAPGDDEPESSSALERRLEELSTPTKGQVERGVKVEMKGVAPPDKVERYLAQLQSEELHAGSPNERVAVNQIDFPSLPAYDRSPPLARARQHIPTLSPSLLDTLSGVEVQFFRPSLGANTGDVDAGPSGFEAGSQEDDLLRRLRDELKLEATVRARDDENAAGWDDRLNKLKEFKTTAGSATTSTAGPVSRSEIGIPPDLGDLEREVRRRQKREAKKGGRVAKRTASDGESDETASSSEDGNESGSGDEDSDGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE84</accession>
    <name>A0A2S5BE84_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE84"/>
    <dbReference type="STRING" id="741276.A0A2S5BE84"/>
    <dbReference type="OrthoDB" id="2530258at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015453545" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="38905" checksum="AB0D4BC6FEAC1B65" modified="2018-07-18" version="1">MLLALPSLLFLGALSSVPAQTTAPFASSTDTVLTTSLSATTTLTRTVMSASSASGNATLTKTSSTIAPAAPTANTTSTTEQSVRLWPPRGGLVVCERVEFAFTGPAVPKTCGVYVTNASTYLQQIALGGEFSSMTGGTFSWLVDLPAGLSVEIQLWVSLNNQVQQFTLHELVVQPSDDTSCIATGAGQNTQSIVSYASSLNSSWIYQAPATTDSSDRQSGSKIGPIVGGVVGSLGGFALVLLAIYLVCRRRARAIQPPPQIGFDSAYGDKSTYGDPASMTHAQMVALSYQGQQAGGSPLECGRQTPLVPYFSPQGEAASSFDSPVRAGTAPELMDVASHHGGTAPAPTPDVVPYSPRVGTQGLDDPATFSARRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEC7</accession>
    <name>A0A2S5BEC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEC7"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015734148" evidence="3">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="190" mass="17966" checksum="E33814FB9069C0D5" modified="2018-07-18" version="1">MRLLSTAVALCAVFSVPVLAQSSVSNLETFPTIYSGTSTGPESTGAATLSGGASPSASYGAFDPSKFPTAPGPAIIPNYTLSNPSGAASSGGTGSSGGGRTNTGNRTTAVSASAVSITSQTSPTASIVTSTVDGSVTTVTVTSSKGSGAAAQTGTSGAESNRSGSAAGAAALWGAAGTVLVAAFGFTAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEF5</accession>
    <name>A0A2S5BEF5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEF5"/>
    <dbReference type="STRING" id="741276.A0A2S5BEF5"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="342"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="518"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="608" mass="65183" checksum="493EDE7E826AE8F9" modified="2018-07-18" version="1">MHPIPPPRRSATLPTPTPTPAFVADPLAVQHAAIAQQHHRSLVAYYWSFAQQGLVAPLTAAFGSDERARQELARTEAVEWAKQCGIQVVEPGAPQQPVYALHTAGQHAIGALDAQPRLSTVPTPVGQTPSPALQRPLPTPQASTSATPAQTPVPPQRARPLPPRPPPARHSTASPGVPSTEPRQLEGRLEQLNLGSAISPAAAQPPAAFAHRDPRASPTEQSPAAPAIPIFSFSVGEDDDTPASAASSTPAVPTFSFACDGDEDEDDASAAGGSSSTPSRYVPPLPTPTAKPRAPRPPPLHPRFDPSHPSHRLYHPTSVMSPLSPTRPTSHSNSDVPEAGTIACSACRDLIFGRVLHALGKSWHPDCFRCAEDGCGARLEVMEFEGTPEDRQGDEDSAAEGLRGKAWCMVHYEERFALECHHCHTPIASADYVPISDPALPPASSYRHSSTRYYHPLHFFCAGCGDPFIDPVQYESRPAPASAQVDPSLSDAPLEAKPYFAHEGHPYCDRCDLRMWRPKCAGCRKGLKEEDGFLELPEEEGGGKWHEGCFRCSLCDKPLTGVYLVRKPVADPASVRNVAAEVSGEGGVDDVALPYCVECFDEVDAIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEQ8</accession>
    <name>A0A2S5BEQ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1622</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEQ8"/>
    <dbReference type="STRING" id="741276.A0A2S5BEQ8"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="135"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="640" mass="70196" checksum="3A3232EFF3A74CED" modified="2018-07-18" version="1">MSTGPGHHGHAAPATEATSLAAMKEQAAREKAVGTDEKRELAGEDGYLDSYDNKPKSSGLDNPLTGISLDRLEAMGRAFAREKGLGEFELEFAKGAQAAQDATVTDLPLLNEEDRNALRREVTHKWNHPKTLYMVGIACSMAAAVQGMDESVTNGANLFWAPQFGLNTAKGTPNASKNQWLLGLTAGSPYLCCAVFGCWLTSPVNKVLGRRYAMFLSSFISLVGCIWSACTNSWQHLLGARFFLGIGVGLGSATVPVFAAETAPPLIRGALVMQWQVWTAFGIMLGTVSSLAFYKVADPVSANITGLNWRIMLASAMFPSFFVMGFAPFLPESPRWLVGKGRYVDAFESLCRLRHTRLQAARDLFFINALLEEEAAVANGRSAIVELFSVARNRRAVQASSIVMFMQQFCGINVIAYYSSTIFREAGFDEISALGATLGFGALNWIFAAPAVYTIDTYGRRTLLLWGFPLMSLFLLITGLAFLIPKENTAHIAVVALGIYLHCMAYSPTEGPVPFTYSAEAFPFYVRDVGMSYATALTWCFNFIVALTFPRLLDAFTPTGAFLWYCGWCAIGAVLVLLFVPETRNLTLEELDQVFSVPTLRHAKYQLGGAMHGFRRYILRQNLAPRPPLYAWDDKMSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BES8</accession>
    <name>A0A2S5BES8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BES8"/>
    <dbReference type="STRING" id="741276.A0A2S5BES8"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="476" mass="51619" checksum="433D313697A0D761" modified="2018-07-18" version="1">MSLDKVPVASTSSLLVHERPTAAQEAEERASKRPRLDDGPRTVSPTQEELFRTGGPAQEHERAHEAANGTPPAPLVSSSSAAFPRHDLLYTLTGHKKSISSVKFSADGRWMVSACESRLEAITSSQNAAHDLRPSAADAPIHLHSLPSFHLHRVFHSHTNGVNDVAFSGDSTLLASSSDDRTVRIWEVDPSLSGQPSVVPPPPSADSLEADQKPEEAARVLSGHLSAVFCVSWSPRGDVVASGGMDETVRLWDVQRAVNGISRIESAALTRLLARCEGKILRVLPAHSEPVSSVQFSRDGTMLVSGSWDGYIRIWDTSTGQCLKTLVNEDNAPVASVRFTPNSNFLFTSTLDSAIRLWDYQSDKVVKAYTGHTNRKYCIPAALTPDGRFLLTGSEDQKLFVFDIQSRQVVHSFQAHKDVVVAVAHHPSIGMFATGALEKDAVVKVWATKDARSSVEADDQEDAAPPMNGIEMQSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFW7</accession>
    <name>A0A2S5BFW7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFW7"/>
    <dbReference type="STRING" id="741276.A0A2S5BFW7"/>
    <dbReference type="OrthoDB" id="2528337at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="74972" checksum="B8D665E3A23A567F" modified="2018-07-18" version="1">MPHASSSPPPAVNSWPSSTGGQPDSMLPSQRGDPYLEPTQFDSESLSAFDLRERVPSYDLQRPASYRDDDFLYQGPSLGDSTGRRTFSRGGPRRSSSFGTLTSPLPFGVNSPSSSLPYDDSLLARSRPGSASATSDMPAGSSKPPNTLLPPAGYDDFGSRRTSQEDLWSSRTRWMTEQGMYRDPLDDDALAVEELSPSYFMQSSGGSNPFSPTMSSLRRSSSTYSMSSSHRSAQAGPYARPTTPTSRGESSARRRSITSDQESASPSKRSSPRKVAQVTTVLDPSGSPTKSIRRIAKLNLDASPSKPESSSSPRKSPRKNSRGAVATGNVPIRPAPDTTLSESSVREVEQILGEIGPVLEPAPLGGGESANEAPRRVSFASSAVRQARVPSVLLPPAPIDVSMSRVALEQEFVDDPDALERIDLPPHHAPFGRTWRSSIDLPTPPKQFPESPYASDDYYRPQTQTYPPAHYPVREGNPAVSSFVLPANPHARSQPAFSHEYATYATGLAVPASPFPPQDWSDGRRRSSASSYEYVPASVRRYPVPATSMWSTGMPMHADYESGPPSYQDPRMYRLPAYGSSSASSSSPSPTSDSRPATPPPISRITPIPITPKGGSPTKASAGSAKGSPGKKKRSPAKGKRQLGAMFVNYSAVDAKKLLNGVAPSGSTRKRREEEEARRRALVESRDAAAEHESHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG09</accession>
    <name>A0A2S5BG09_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="13" type="ORF">BMF94_1335</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG09"/>
    <dbReference type="STRING" id="741276.A0A2S5BG09"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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            <begin position="5"/>
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        </location>
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    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
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            <begin position="175"/>
            <end position="389"/>
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    </feature>
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            <begin position="397"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="397"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
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        </location>
    </feature>
    <feature type="active site" evidence="9">
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        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="199"/>
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        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="201"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <begin position="436"/>
            <end position="439"/>
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        <location>
            <position position="522"/>
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        <ligand>
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            <position position="205"/>
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            <position position="332"/>
        </location>
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        <source>
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        </source>
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        </source>
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        </source>
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            <dbReference type="Pfam" id="PF14306"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="POY75712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="577" mass="63730" checksum="8020C356530B0F4C" modified="2018-07-18" version="1">MSLNPPHGGVLKDLHARDAPIRAQLLAESEQIPDIRLTERQLCDLELIMNGGFSPLEGFMGKEDYESCVETLRLADGSLFPMPITLDVSQAQIEALKLAQGVRVTLRDARDESPLAILTVSSIYQPNKSNEAEKVFGADDKAHPAVTYLHSSVKDFYVGGTVQAVNAPEHYDYVELRYTPRELRAYFEKLSWNRVVAFQTRNPMHRAHRELTVRAARQQRANVLVHPVVGLTKPGDVDHFTRVRVYEAIIRTYPKGMAALALLPLAMRMGGPREAVWHAIIRKNFGATHFIVGRDHAGPGKNSQGKDFYGPYDAQELVTQFKDELAIEMVPFQAMSYIPEQDIYQPVDEIPKGTVTADISGTELRRRLKTGAPIPDWFSYEQVVKVLRESYPPKASQGFTILLSGYVNSGANAIAKALESQFQQQAGRSTSLLLGDTIRSELSAELGFAPEERHRNLQRVAFVAAELSRAGAAVIATPIAPYDASRKSAKAHIIQNGGAGGGNFFLVHVATPLEYCEKTDRRGVYARARAGEIKGFTGIDDKYEVPEDADLVVDLSKQTVRSAAHMIILLLESAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGD1</accession>
    <name>A0A2S5BGD1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="741276.A0A2S5BGD1"/>
    <dbReference type="OrthoDB" id="2538468at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="120"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
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        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
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        <location>
            <begin position="338"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="397" mass="40386" checksum="E100D6AC74A54FF1" modified="2018-07-18" version="1">MSTEVAAPAPVATTSETVPATEPAEVPAAPVVEEQPAAATSAPATDDKVESPESHPASPEQHKKRSPFGDLKNKLFHHKSTSPTREKEHEHVATPEEMAKENAPVVKDETAAPLVAADETAPEAEAAAAAQSETAPAAIEADAHKKPKSPGVFDKVKSFFGENKKEKKVKTPTEEKAEPVATGETAAVQGETAAAPTTEAAGAVTAPEAVAAAEATASATAPVPQVIEPIPAPINEPATTTEAPVGAEGETVLAPVDAKKEGEELKFDEQAKTDDKAPKRDLAKLSRRLSAKVGAFLHSPKKEKKEKDVVTAAEGGEAPAATEAPKIETTVDESKLDAAPAPVVQAETEAAAAAPVAAAETTETPAAPVEAAPLEAAETDATKAEAPAAAPVVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGU0</accession>
    <name>A0A2S5BGU0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGU0"/>
    <dbReference type="STRING" id="741276.A0A2S5BGU0"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF11">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="96" mass="11167" checksum="D2BBE66D7940B8AB" modified="2018-07-18" version="1">MFCTIDDLHPWSQGKGYGREAMEWLLSRAFVGYGLNRVQSACWTWNEPAVRLYKSVGFQVEGTKRQACWQEGAFRDEYIIAILAEDYHKRRSESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH23</accession>
    <name>A0A2S5BH23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH23"/>
    <dbReference type="STRING" id="741276.A0A2S5BH23"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="567" mass="62913" checksum="A2097A4AA9B17A3F" modified="2018-07-18" version="1">MLLYSGNKQFAAKNYKKAVAIYGNALAANPSDEEAGVILANRSAAYTHLQKYDLATADAEQAAERRPRWPKAQVRLAEALSRKHAHEHALKAWQLAIEYSDNEDDKQRYRGLMEQARQAAATVSAKNAPARPNYNIMQSLDDAWYTKLERAIKSGQLPAHEVGLGMHLAMRSWQECEKGWKAIDNAIEILPDGSAKTDLFNPFTLSSLVETILTDQSGFHIGYSEKDAKSMQEKLNHLLRAEASAERIIDDLDARIAVVGRDRIRRITASVIYNHIIIGFLAMAGSKYGYAIEAAKKAVQLLEAGLRKWAHEDPDTRGNIFSIKLIRNAKMEVMRCLVHGYQTAKTNSARKAFPLDEMEKWAKAVLDDKIPAAYWQRSNDIAWRLGYEALPQWEANAALGLIGNIRVAESLGDTKVAGVVKFADIEAAKRAAKYYDLAASLMPDDFHDKRMIMYCALYAHLRAGGLRVSAIRSRIAAIQHCDSKVSPCFGPLPEFEASTFCITQHEAVAGLPAHVTVKAIPTFRCPPGRDPRDFISEATWAGYPGDAGVADIVDIPSHMRNGMSGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHA2</accession>
    <name>A0A2S5BHA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHA2"/>
    <dbReference type="OrthoDB" id="2522835at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="225" mass="23888" checksum="3399DA3BC1A3AE89" modified="2018-07-18" version="1">MLPLGRPPTVSLTVDSPTHLTASSAGLTPRHTLSVHDCDGANREWVVDSTVAKVSIFNSQNLTLRLNGRNLTSTVEVFKCRDVRIVVGPKNSPAATDSEAAEPPQPLGTLQLDPPLDNVAIEYASPTHVGKIVIAPLPSEDALGRATFGFSQLSFRSASEAEPTVLFDERGALHFPGQSGERPVVISPGVGGFDVARQLVVSCGQDGRWQVTGLERGEKDCPVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHW9</accession>
    <name>A0A2S5BHW9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHW9"/>
    <dbReference type="OrthoDB" id="2532910at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="274" mass="28539" checksum="225EADF1FA924DDD" modified="2018-07-18" version="1">MYRSALGLARAQLARPVAPAAATRSFANASVRLAAKPAEEQSAQHPGKSGLPHLENPSLSEEAVHADRLGQDPLKGHTAGSSTSTAGATAENVVDQVKDAANSVAQKVKDAANTLTGAGNPQKRSYHSTAIRRENPAGSKPAEEQSAQHPGKSGHDHLENPSMSEETVHADRTSKDPLPGDKKPSRQNNGGDKQKNNVSATAGQGGTAASVEPAGKPGGNDTRIEDLPDGEATKKSAESASLSPALPLEWNDPTKGDVRLKKRIIGIVAPQHWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHX4</accession>
    <name>A0A2S5BHX4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHX4"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="455" mass="48419" checksum="407CA28D727DC926" modified="2018-07-18" version="1">MASALLRRLRKRPDAAPVANASSPTPGAAPMKPPPSPTARELDHDEDVLRGAPPRSYAQLVDAAEELVAASWDPSLPVRYWLNAARELQLEAEKSASQSDPETAFIRAETVLKLLRDVLPRHHRGWQSLALEERSVVEHVLRAITPLHSSLRAFLLSRTSRYNARVTSDLSTSASPALMLRNTISAASDAYVDSTARGYSPAPSTSTSAARTSTGPPRVNKLRSAHVASTPTDNVGAATAALPAPGEEDDASPSLYANDPLTSRQDGRRIPRLAETLYPAVPPLPARPMSNVASGPLPLPGEGDSDDDVAHLRSLEPTTAPLFVPQAYPTPPIPPTPPPSVLRRLAASTQPSPPKFPSPSTRDGHGQVTMPPPAHETVGTIAPAPDLAESLEPLRKVLLPLQLVRTFVDEIAVVNTRNAIETCGLLLGVQLSPTAAIKSYPRVKYATGGIESLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI02</accession>
    <name>A0A2S5BI02_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI02"/>
    <dbReference type="STRING" id="741276.A0A2S5BI02"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000015">
        <property type="entry name" value="Heat shock protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="385" mass="39431" checksum="0835A32C26845AC0" modified="2018-07-18" version="1">MGADFYQRLGVARDADDDAIKRAYKKLALKHHPDRNKGSEDAAKKFKDVSEAYEVLSDKDKRAVYDQFGEEGLKGGFSPGGASGAGMGGGGFNPFAGGGGGGGGFPGGATFSFGGSPGGAGGRGGFTASDPNDIFASLFGGLGGGGLGGGGRRQAGGNPFGGMGGMGGGGGFPGGFGMDIDSDEGDFGAHGGASRPPPPPEIVKPLPVALEDLYKGTTKKLRVTKKRMNGQEEANTLEVAIKPGWKAGTKIRFAKAGNEMAGGSQDIVFVLEEKPHATYKRDGDDLVYTYKVPLVDALSGPAGGGSPSKSLTHLDGRTLNFNIPYPRGGGTPLKPGQEIRIPNEGMPITRKSATKPKGDLVVKLDIVFPDRITSAQAEGVRKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI37</accession>
    <name>A0A2S5BI37_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI37"/>
    <dbReference type="STRING" id="741276.A0A2S5BI37"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="251" mass="27451" checksum="CE0783CA6A141C60" modified="2018-07-18" version="1">MLHRKAYVIEEYIKPEQLPNRLVEWKDPELKENEILIDVHYAGLNFFDILQIQGKYQLKPPFPWISGAEFSGVVAANSPIPKGCTFVPGKTRVFGAGQGSYAEKIKVDYRTLIEVPASMGLDAAAGLYVTMPTSYAALVNRARTQPGEWVLVHAAAGGGSIQKIPANLLLLKNVAAMGVHWGAYARNEPEAVPQVWKELLALFESGKVRGPVFEKVFDGLEAVPEGLRALGARETWGKAVVKVKGGREGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIA6</accession>
    <name>A0A2S5BIA6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_0350</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIA6"/>
    <dbReference type="STRING" id="741276.A0A2S5BIA6"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="448"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="554"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="672"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="328"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY76509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="781" mass="85080" checksum="965BF1536BB61A94" modified="2018-07-18" version="1">MSIMTPPGEAPSEPPLSPPPPPPPSPVLGALGLGPDDALNEDPLTYRTNAQVLDIYTHASIAPPPPKYDPDVSLRSAQRSESPSRTTLSEFRESEGQARRLTRLRSVFDSLPPPAAAAAAAPAVPTTSTSNDDAPPRSDATEAERCARDQKAYLRELWGQCGSVEPGPLPSTETTESEPAATAAAPERGQRPSPQKTKRTASTTATRWKAFEQYAEAKERELWRAFCELDRDGDMRLRKPEVREACRRAGIDLREEALDEFVRTVDSDGDGAISFDDWRDFLLLLPRPISMKEIWRFWQTKRIERPSMSRLTQDGDVVIGRGRSGWRKLFGRSSSSSSTTGTTPANAPLPKPLSPRTTDLRQLEPINDEQRYMSACARMQADDRERERKRQSAEAVSKAGQAGPSLEFEESGVVAAEPARAQPTASEPVLVPEEEEEQELDATHDMFADAGKFLLAGGVAGAVSRTATAPFDRLKVFLITSPASKSATPPRGRPGAGTLIEAVKTVYRQGGGIKAFWTGNGLNIIKIFPESAIKFLSYESAKRVFAQYWDKVPDQTMISNSSRFVAGGIGGVASIYPIEALKVRRQQSQQDIDRKLTRAPSQTRVMSSSGGAMRGNALILQTARDMWSRGRFRYFFRGLPAGLIGVFPYSAIDMSTFEGIKLAYTQWAGEEPGVAGSLAFGAISGGVGASSVYPLNLVRTRLQAQGTPSHPQTYTGIRDAAIKCYQLEGWRGFYKGLTPTLVKVVPAVAISYAVYDTSKKMLFAADDHPSPELSSDSESES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIN4</accession>
    <name>A0A2S5BIN4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIN4"/>
    <dbReference type="STRING" id="741276.A0A2S5BIN4"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="103"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="401" mass="45476" checksum="CA5CAA7B2C132EBD" modified="2018-07-18" version="1">MAAVVQAPTDSSLTRLSSYVGFDSITRQIENKLLKRGFQPVALRSYPLARLDNGARYPNAHVWFHMIEKRESLAPGQWQWTKEERSRTNNLSASPTTPLADPAAFPCLAANTGQSGLGKSTMINTIFASHLVDTKGRFEADEPIRQTTEIQAVSHVVQENNVRLRLNIVDTPGYGDLRVCFKSSCTPCRNSWEPIIKYIKDQHSAYLRKELTAMRDKHIVDTRIHACLYFIAPTGHTLKAIDIVVMKKLSEVVNVVPVIAKSDSLTLEEREAFKERIRAELAHNEIRVYPFDTEENDAEERQLNQAIRSMMPFAVVGSERNVMVDGQPVRGRKNRWGVVNVENEQHCDFNYLRNFLTRTHLQDLIETTSMVHYEAFRSKQLLALKESSAAKQQAHQQSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIT1</accession>
    <name>A0A2S5BIT1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIT1"/>
    <dbReference type="STRING" id="741276.A0A2S5BIT1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="358" mass="38310" checksum="88E0BB0A2CD49FCF" modified="2018-07-18" version="1">MANEQIPKTAPAVVFEKINGPIVYKEDHPVTQPQDLKPGEVLVKIECTGVCHTDLHAWKGDWPMPPKQPLVGGHEGAGHIVAIADGTTTTFKVGDAVGIKWLADSCLNCENCRMGAEMTCSLAQCHGYTVDGSFQRYAVSYARHCTPIPDGLPLEVAAPVLCAGVTVWKAIKEANCKPGDWLVVSGAGGGLGHLAVQYATAIGLRVVGIDTGDDKKKLLDQYGADAFIDFKNFRDEGALIKEVKRVCGGEGPHAAVIASAGGAAYNDALEYIRPHGSLVAVGLPPDTDIKANVFWTVFRNVRIIGSYVGNRQDAIEALDFALRGKVKPQIVTEPLKNLEDVYKRMESGGIPGRIVLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ26</accession>
    <name>A0A2S5BJ26_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ26"/>
    <dbReference type="OrthoDB" id="2523617at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7827" checksum="9ABEBCBCDA0B261B" modified="2018-07-18" version="1">MAGSHIDLRKRNAAFQSKIGKSNSIKPVEKEEHRPVPKWIAYTLLVLIVGGFGLELAQLVFNFFYPAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZW2</accession>
    <name>A0A2S5AZW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6928</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000150">
        <property type="protein sequence ID" value="POY70066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZW2"/>
    <dbReference type="STRING" id="741276.A0A2S5AZW2"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="11">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="642"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="692" mass="74559" checksum="20E691FA6F429A8C" modified="2018-07-18" version="1">MASSFVFYKFKSQREPSRIAFDGTSITVFDLKKEIIAENKMGKGADFDFAIYHADTEEEYTKDHELIPRSTSVIARRLPPARPGRGNATKYMAGAEESGQGLQAGRGAAPEPRGGVGSGFSKDMYTKRFDGREDPQPSGSNQKSVQISASAPNDEASAMAAMFAATNTQWQQTQEQMANATPIYRNPNAANRPPPRDNAAQANKPSFRDSGMAHREPPSGYICYRCGQKGHWIQECPTNNDPAYDNRPRIKRTTGIPKSFLMEVNRPAPGTKDDEDDDEDGVNGVKAGVMITADGGFVVARPDSASWLAHRAITANMSASDIQNLAPTDPDLTCPICSKLLRDAVLTPCCSTAFCDECVTNALLDNDMLCPECETRIKSLEKLKEDDDRRERAKKYVDETVAASKEAAEEERKKVEAEEERRKALEAKKKAEDEAASAAADADKIDGDKSDVQKKGTEDDQKANEDELFPVRPQEILNPRKPRPGEIPPEERDLPATSTVATTSASPQPAAVASGPSAQRATSATPVPNSGGAETPAVPIGMSAAHQAQQLRQQQLRAQQQQQMLAMQGGAGMPNPQMVQQQMFQLTAMLQSPALPPPMRAQLQAQLQQCQMVMMQIQQRMAMGMMAMPMQPPTGPRAGVGGGMSPQMVVHGGAGAKSASPVPNGASSAGAQKRTREEEGEGSPAAKKATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B049</accession>
    <name>A0A2S5B049_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B049"/>
    <dbReference type="OrthoDB" id="3365743at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="154" mass="15658" checksum="AC240C2EA825F701" modified="2018-07-18" version="1">MSGLSSPSALITANAASTSINVYSIAKIGLGLAGLLLPAFATTTSTPFKFAARGQLKASKPTANTLSPQAGSPSESALAVRLVAARDIALGLLMRDTTASVVVRALQADIFVSLLEIASTAAGYIEGTLSQETALSVAGFSTVFASFGLWILNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0L4</accession>
    <name>A0A2S5B0L4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex mu/sigma subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0L4"/>
    <dbReference type="STRING" id="741276.A0A2S5B0L4"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="6">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="217" mass="24071" checksum="8F6C170E7EBC7C7E" modified="2018-07-18" version="1">MIHGGPESTRVCPTYRRRSGYPVLIFNNAGKPRLTKFYSPSSPKTRAAILQRIYSLVSVRDDSLCNFVDLPPGFGFGETGEKEHAGDDDLRVIYRHYATLYFVFVVDQSESELGILDLIQVFVESLDRCFENVCELDLIFHFDDIHTLLNCIITGGLVLDTSLESIHSTFKAQQDVKKASQNGGGLSVSGLKDAAGGFLAAGDWDRLSFANLTRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0P6</accession>
    <name>A0A2S5B0P6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0P6"/>
    <dbReference type="STRING" id="741276.A0A2S5B0P6"/>
    <dbReference type="OrthoDB" id="1872003at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="226"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="442" mass="46035" checksum="56864AAD65BFEC6E" modified="2018-07-18" version="1">MPPIDKTLESSRTLLSSLSSFASDRSQDMAQQAYEFLSQTSTRPQMPRRRRSSASTAGDATGLQQLSTLSLSSSPLSSSSDSSAPPSLIFSSTSPSPSSSLSSSPSLGPTKRFSHSAAVPDPLSLGAPLQPNSVELAKYASDIIRNEAYALLALAARLAPAAYPLLDDDGAHVVRATDSSSSAGTDSSDDGCEDSDDAAYAKSPVGVESHVEESRTNQAFRNVVTLIQSMPRHGKILISGIGKSGIVARKMVATFCSLGIQAAFLHPVEALHGDLGLICSCSPASPCDTVFLISHSGATAELMRLLPIVRPRVRSLIAVTRDPDSVLASSCHGWLDAGTGVNRSGLPKATTDEADSALPAPTSSVVSALAIGDALALTLSRLRTGWDADSKRRREDFYHCHPGGQLGIQLGREGRGVDMPSSATSPTAGNKLQPAVRLAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0R7</accession>
    <name>A0A2S5B0R7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0R7"/>
    <dbReference type="OrthoDB" id="2529160at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="826" mass="88181" checksum="021B47E5C2EA8000" modified="2018-07-18" version="1">MHTADGIVSLPSHVAEGEDLVCRDFGLPSPLNGPSANATDKEQPLESSLPPAQSVPSSPEDGSQGVSRWSTSASGDSLAARCVSVYVDARDETASEPSNTDESEQYRSSGGSFETDVVQPSRRYSELPSRLARRRSLGEPDASGAGDQLLSLHPALGVIKVGPRRHSSALYANELENSPVPSRAAPIRLKPLVLTPARSISTPLTTSTREKRGGGPLSPTPSRRYSSPVSPLSTPAQRSAPEFARPYNGRRRSIGYRAESLDETDISPVDVKRSGSTSSESTTFSSDFSRRSSVETCDTQATTPSSSPEKLPFWTEKTRLPSLQNRFDPQRGLSLDVVLETDDDGVDARNRTSGSHARYRAFWEDEAARNESAFQDVCVALDELAPSFPTPTLFFDTAMPSATPISRSASTTSNESGSPRTPRRGKPIVIKPSAESPVTDDRRQSRRISRIRQSRPAADAMEMSPKQDEGKAPSAPVSSADVAKAASNAPRRIPRPLVWPPPNETKRLSLAPVMAYDSEDEDDGLASSLSDLDEKRASAPRRFAHMPRSARTRDQTDDDDPANILDFLLEEPVKITEVRLGPPVAAAVAKPTPRPQPRPLVAPKSPSSPKSSRSFASRLLGSFSASSASKGLESPPSKAAKKRPTSLMSRSKSAAPASGGERPRPVISGPLELEATETLQSDASGASSLRSVSTISLGQAQRSRSASFEVRRVPVSPTAVAAAVRESADEEGVAEELLAHFTEHGSATQLTTRSASSPSSPSHAMKKLPSTPLLLSPLWALPVTELPRNPLAWAERCNEQPQLHRTASLSSIASAGPTAALIGSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0V3</accession>
    <name>A0A2S5B0V3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000129">
        <property type="protein sequence ID" value="POY70291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0V3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0V3"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="228" mass="25263" checksum="E8F10CCECFEF7A88" modified="2018-07-18" version="1">MTKTQGNFKLNMSAGSFTDSEIIVLLGENGTGKTTFVKLLAGKEKPDNEADAQHFSVSLKPQTIAPKFPGTVRELLLKQIRAAFMHPQFNTDVLKPMNLENIMDQLVTTLSGGELQRVAIVLALGKPADIYLIDEPSAYLDSEQRIVASRVIKRYILHAKKTAFVVEHDMVMATYLADRVVVYDGTPSVESFATAPESLLTGMNKFLKSLEITFRRDPINKFGSLLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B119</accession>
    <name>A0A2S5B119_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiaminase-2/PQQC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B119"/>
    <dbReference type="STRING" id="741276.A0A2S5B119"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19357">
        <property type="entry name" value="TenA_E_At3g16990-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053261">
        <property type="entry name" value="Polyketide-peptide_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813:SF2">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="152"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="275" mass="31063" checksum="E69E07E0D142F0FB" modified="2018-07-18" version="1">MASQDMTSKPTAAPVASAGPKSFAHTMLERYSDEVRLATEHPFLAAAGRRELTREKLSEWLTQDRFYALHGYPKFVASLIAALPLASPTHQTKAQETLALLAYALTNIARETEFFDSLPPRFLVDLEADPSPEERDVRFKTNLGPLQGKMMRPTTRAYVDLLISTGAEAGRIGGGMEEGIVLLWAMEKLYLTAWRYAASLSPIPSSSRNPSDPRTSAALDELVENWTNEEFGEFVRECEHEVDKLELQEGSDEWDRAEEIFKYVLYLEQRFWPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1D9</accession>
    <name>A0A2S5B1D9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRN6 K-rich C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1D9"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="2">
        <location>
            <begin position="938"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1111" mass="118462" checksum="23286413AE238F0F" modified="2018-07-18" version="1">MSVQEEPRSSPCPACREHVSDATSSSRQYACTTCGSAEASRADAEGAGVGKESAWSTTRPQDVQQWPEPVQLVPGVEGAIRLEPKCEPNGRIIALESQAMTSRDGSLRLVAAPGRTRLAYPATIDLQDEEEERDLVGDPVKLELDGQLLHSLHAALPSDPVHPAVFLNASLRERPTAGSSRIISTPEPSEANHGNLCSSAYFRRKEEGDLVCGTVWRRAAEDGRRPTAVGWGSFAPLPISDRPRNNKGKGRATDGSLGSDSSPDTAFCAAPTPLFGTSAPIHQLQLAPLDEASHMLLACRSRTSLDLLHLDAGSDPTGPTVLNQFQYSARVLNSRPIADISLGGISAGYGKPGSGLVVDTEGSLFGFGLDRLAPNRAVVSPWLSSQPEMFRLRRRRKKGAGYSSGMARVSWGGLRGTDAVVAMEDEVLLYDLRSPTSSTVLIDEELLTAHSPFNSPGPARVTSLLSRSPSHPTLASASPTAIHVVCTTRDVVWIDERMPGRDVLRWGHGRVGIEGKGSDRTLRLHELSPTVSHDTGPEVVQRIALTSRLHPRVDIFTTGLGPTTAPRSLLDPYTLTLPPLSWRDTPMNPHAGISFISITPTESPALRVSDSPAPASDASSTADAGVGLDGLEHGAADGTDDGIARQPCIRLLSLGARGDLLECDLVQGHHARTYANRDAPGPVAEQDAQSEKGFAQSLPSALVGRTALQARHKKLGCANLVRAIRNDIRAYDGLDGRPSERDSSDAAPPDFAKFTAEAAEERRDVGAVTSLELALLIEKERREGDAAVSALPRQPFPFSAPPSSIGAASHSSSRPHAPALISLESKDPATHFDAAITACTAGVRASAGRPDQVPWSGATEILLPRAVEPDEPTSAPNQPQPIDQDPPSLHFAYLRPVEGDSDAEDENDEHSFLKQQRRKHRRRKGPRPSLEHYGTRLLLAEWHIGADPRSYAWHNPYEGEKNKAALHSSSQVATSRKTRKKRDGTAAVVSFDTSSQSLPSSFSPAFPPSSPFPASSQTYFPPLAPPPSTPARPRSRFEPQLPPMSSQDWTQVAATQPAIAVTAPVDSPAPAQPPFAGAASQTVPGAFGSRLSAGAPGGKDKKKGKKRVSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Q2</accession>
    <name>A0A2S5B1Q2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000102">
        <property type="protein sequence ID" value="POY70686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Q2"/>
    <dbReference type="STRING" id="741276.A0A2S5B1Q2"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="136" mass="14167" checksum="D6971C854CDC4B12" modified="2018-07-18" version="1">MVCAKCEKKLAKQGTLAATDVWKGAGQQNQQRKIGENKLLSSKARYSPYAPPTAGASSSSSASSMPYGERNKRAKAGKGEDATAGPDLAGGKGGAVGRCEVCRSVVARPGAKYCQGACAMCGKEILDTKMYKQSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1U4</accession>
    <name>A0A2S5B1U4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Small monomeric GTPase</fullName>
            <ecNumber evidence="9">3.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1U4"/>
    <dbReference type="STRING" id="741276.A0A2S5B1U4"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="265" mass="29212" checksum="579CFE92D896B054" modified="2018-07-18" version="1">MGDSSYDYLFKVRILATAGTTCRETSWLYPARPTDKPTDERLLSRIRPRAPLHVNCELTRVEQVVLIGDSGVGKSIVLSRFTRNEFNLESKSTIGVEFATRSIQVEGKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHATYVNVLRWLKELRDHADSKIVIMLVGNKSDLRHLRAVPTEEAKLFSQENGLSFIETSALDASNVESAFQTILTDIYKIVSQKQLEADPISSQRPGAGSTIEIAPSANDGGQAPGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Y1</accession>
    <name>A0A2S5B1Y1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Y1"/>
    <dbReference type="STRING" id="741276.A0A2S5B1Y1"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="529" mass="56390" checksum="2121B8CEEE0C2217" modified="2018-07-18" version="1">MENPWGEPSPPLALADTTSTESALEPEQRRSVDFAQDDDDAPAWDADDSSIGHKSNDSGDDDDDDWAREARAANLTRLNQQEQLERDDQQPENGADRGSEEPSQTEATTRDDDDAAQSVPSADEEPRLSTQLPPPVPMISAALPSFDADAGQQMDDFPEDDEPLDARATTAPPATAGFTEGDDAFADDDDFDDFDEPAAEGGAGGDDDFGDFGDFGDAAPLDEAAFESTPLPSSALDATPTPFASTSTASSASYPPLRFELGDRSRQAISSQLHDFWEGAFPAAARAVNDEPERQVEGLAQILVSESSRSLWAELSTLPPLRPVDWRRSRIRREHLISMGFPISQEEEAPLPSMAAISSLNPSFTVPARPSSAPPPTSASISSGPGRPSTPLGTTYSASNGSANNFGGGRPSSLQRSTGPGGFSPSPPPFDRERAEQALGVAEEDLPLRSLAELRDLDAELDRISVEASELLTHALMMREKESQDKEVYNGMIQDLVVAAAKMKTSSAVSAAAGKEPKRSGSGRWKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B253</accession>
    <name>A0A2S5B253_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B253"/>
    <dbReference type="STRING" id="741276.A0A2S5B253"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="116"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="615" mass="67402" checksum="5D9B458F3036FDC7" modified="2018-07-18" version="1">MSPSPLYDAYQSFSASDLQPVLSRIAVVALVVVVISIVTTLDPNSNSALTWPAQTLDKLSGMATVGISALLGRSSVGKVEWGKVDNASEQAENVVRRYRDTKEGKKKVEGGGQHLPGLLNAAGNLCFLNATLQSMASLPPLLSYLDELVASAEDIDLETPVSLALVNTLEALNTPSSSRPPPLRPVELANALVASSPTRRRLLANSDQQDAHELWVMMRDAVEEEAVRLSEALRRLASRGSGLKEVARMQAGLGLAVGTKVQRRAATDPFFWLRSQRVRCMECGYVRDTRHEGEELLMLSVPPISHCSIHDLLAEYTKTDLVSSYNCRRCALLATLAKYKDQRDRLALTNDSSASPASPPVKTPESNRKPANPFEMPTPAPSTAVPKMTASRKDRRRKVQKLVDRVQEAADANGWERELGEDIKVERSEVAAGKMTRFARSPDVLAIHLNRSAHYSYAGPVKNSCQVTFPEYLNIAPFSDGTVRAPTDSTEPQPTDLYRVASLVVHYGSHSFGHYVAFRRRPPSLDVAEQSEVLPEWYRISDETVQPSSADEALRANPYLLFYERVDGAGRPRAAQDAALPIETDALLSHTPARPRIVERWRANSPSPSQADPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2J2</accession>
    <name>A0A2S5B2J2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ERCC1-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY70999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2J2"/>
    <dbReference type="STRING" id="741276.A0A2S5B2J2"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="137"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="357" mass="37377" checksum="A9B178A1583C4DF9" modified="2018-07-18" version="1">MSSEAGPSRQTGPSSPVRPVGTASTSSSVATSSTSTPGSGTAARAAAGPGAFSAGGAPRGAAASTGPVSAVVRGKQPAQPMTAQAGSRPGSVQQQAGTGVPRTSTGGQQGATPVNSTTGPTSVGGPAGLVRRQVLNSILVNTRQKGNPVIGHIRQVPWEYGDIKCDYQVGATSGVLYLSIRYHLLHPEYIHQRISDLGGSYNLRIMLVQCDADNHTAAMKELTKIALINGYTLMTCWSAQEAGKYLESYKQLERKPPDMIRERVDDSYMAHLTSALTSVRGVNKTDVTTLVSNFGSFSSIVLASPAAVADLPGLGDKKVRRLREAFTAPFTLQSRNKKRKVVGDAEKRGKSGEQVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2W2</accession>
    <name>A0A2S5B2W2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2W2"/>
    <dbReference type="STRING" id="741276.A0A2S5B2W2"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="467"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="750" mass="81564" checksum="8D7F4E0A431D1D08" modified="2018-07-18" version="1">MAVVAQALFPDHEQTIQLHGQRDKGSKLGIDVGKGAGGEGYIPSPRSRAGSIRSHDPASAPPSPSREDVPPMPSKANGATSPVARQLYLEPEAYDSAPMNGSSGPKGHAALGNGYPGMQTPRPRAKSVQVVEPSEWHTVSAANGAARSASLAIPPSVPLKSSSAPHTIASDRSLPLPAPTSALPSSRQASQSFGVPHSTSMSSNLSAATSNSSHLQHSQRALPAAPHTTPHPGTSGCFNTATDPDGVAALVQQLYARLDDQGVFGDGWDEGKERSRDGIILRLDPNRDLPPPSSPLQARVAVPNDPDLDAKADRVLRKVDRYGFFSNSHPAAVACQHHRLATLSSAPFNIIPNLSSSSRRQSKVPPPSSNGALSADQFSSQSNMSPLTHRASSSSLLASNAICPEKIALETKRIDKWAAMLSVARRDSGGNAQDWNVNASWWNGRVPGGGGGQSGKYRKLQRRVFKGVPDRWRRAVWGLMMEKMTGEVALQSRSRVPSLAELEAEYTHLVQQPYVQDVQIDLDVPRTISGHVLFHTRYGQGQRALFHVLHAFGLRSEDIGGYCQGMGPIAATLLCYFEPERAYAGLARLFDQYRLSHIFAPGFPGLHEAFYVQEKLVELLMPNVHAAFATQMISTSAYGTKWYITLFANSVPFATQLRLWDGLLLEGLDFLILTAVAIIWHFQHDFTSPSASFESILSRLSSYFFVESDDALLRWIRKTLRLKGLREKMKAWRAEWQGFVRDGTSESRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2W7</accession>
    <name>A0A2S5B2W7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B2W7"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="490"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1436" mass="158242" checksum="35AFC7263C05A91D" modified="2018-07-18" version="1">MAAPRTPSKTRPNPVSPSGFRPATTPSKGDPQKAAGKSKAPEPLPTKITAEAGGAIFAEASTSVSNGQTTAFATRNAAAQGWSEEQKEGGELSQNLLAAADSVILVVDSKPHRLKMQQYCSWLHMFEHARWLHGGGFKAKDIIWPNYPYQKTGDRSEEPYLERMHDYLASIASKKVSRPDPSLWTEIPHCESRDELNAAFKLGTIHFSGKLSSDSNKNLVFKLLPPCAGMGSSLYRRYGSDRFFRVNLDDDVVRAAGQPLEVHDFDKSPRLRTQIQTLFSKPLFIFGRTYRPFCWKDGAAVYWAESGPHIETIPLVEFAQRVHLRWIARVDSKADLTLSQYLDVSLNEEMTVAKVLRTPDLNSDSLKMSFAAMQLICDEVRAKFAAKGINELLPGSYLPSCIRGTVIHTANGATANMVWQLDYSSAPGTPTAVTPPEPWIQLRSCGTDFPAVNRPGLKFQLEYKNGKKLEVRVPKGLVPKWMEGPAVRKDEVVMTDGCSLMSPAAMRILAEKLAASRRETDIKPNLPAVAQGRIGPGKGVWAIAPRTSWSGATDVWIEVRDSQYKFKDEQTREFVFELHSVPNGNRASAKHGKQMLEVLSHCGVSSTAIEQILATQVSTGQDAFRNFSSTPELLYHIEKTCGVLEDRTMKARMSSDPGALKLLADGVSIPPDADTADVTSGDQESSSFVHDRRLDPSSGAPNVVTEVVVDLLQAGFDPRQNPHLAEKVRKVAEGQFDRISLKIDDEYARMAFVVADHASCLRSCAQSLYGVLSEGEFFFQTWEAVPDPSGYGQRTVMVGPALLSRSPAIQPCDVQKVEGVWKSEYASIFDVIIVSTKGERSLCSILSGGDYDGDKLVVTINPAFVSAFHQASADPRFADPPFEDEDYFEVDRRRLRDVKQIFDHGENDKLAAIFMEGLHAGTQHGVLSTYHTSMAYSHGLADALTSKLGHLFCRALDGRKQGLSFSPKKWEALKQELPTSCRIRPRWTYRDDGKMVPPGAKDPERSSRRRHPMASSGIALTYRTPDALVRVCDSARTTTRQAWANWMKEQPFKFDEHLAEPWEAAWSAAALDQGGPFYEDLVMIRNHVWTLLKEFRELFVEWCRQKELRANDAKAREAPGSPTKSPSKGKAEYRASSAGQKEDLIRLSQRFWSIIERDSSRFRSEKLQGAEGAVAVRRLLASCAYVQPLRPSALPVHAPGSAPRSAPLEISAPVHVPSNGFLSRLRGSAVATTIVATSSGSQTVQTITPPPQEGDEPMEVEVSYTQLDDFAWSQLDDEQLKVTTTTPFSSRKSSQTVTGTELASSAELASSSTLIPPSAEDVSTLCPRGLADEHFHETTGTVPIRFCFDMAHRDVNALKADALTRELHKHIPGAVGIQAPKIAPPILDVLQVSKRCAGINAVRAKVRPRTLLGQSETPATERNANGSPVLKRARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Y3</accession>
    <name>A0A2S5B2Y3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Y3"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Y3"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF144">
        <property type="entry name" value="METALLOTHIONEIN EXPRESSION ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="748"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="776"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="852" mass="88505" checksum="20B7DEE24293AE1F" modified="2018-07-18" version="1">MASSSALQNSPPLAAAQQLAAVEQPAAGGDASTGGNPRKRAPSPLSISRQDAQRPFDFARRRSSSSFTATAIGNYMASPTSDLRSNQPLPTIEPAARSAPDKAPPPIRVVLSPSTSSHPIITESPMTSMAPMSLPSTSSDVQRIRPKGKGTLELERVLDMWAANTPTKGAFPASVALPFASGATTSAATSQPFLTHSIVSSEPEALDLAISTTRNLPGTSGPVFADFGQLASFPATAPLSRGSLSVEHRPPRRQRSRSEADLLRFDTMSLGGISLADFLAGLSNGTAPAAQSLNDPIPTQPFSMLSAPGLALEAGPASGRPQGLRLLPPAVPISTTGNTEPSPLAPAPGKPYSFSRGLELKITPAPPASGKAPKAARGRRARSQEPGHRHAKSDDLTHLLSTLPNGSASSQPVFASANGHLAPPPVYDPALTGQTSTGPALHLVAQQISPGSNDQGTGSRPEFISLPNGMTLPIAYFAPLPTVPGSGMDAPATAAPATTVGTTLEPDSIGHLPQFSPQGNALALAAAQAAQAHAAQIAQAAAVATLQYSNGGLSTDGIDVHSQSPFLPQPTGPYSIPTSAGGPYSYPSPNDPSLMLPTPPPVPGSSSRKTKRTARPAARTAAADDFIAADPEDPTDSSSDDGEDDDGDEYEDEPKPKKQRLAPAAPRASAPKKPGKGRAKAATKTPAAPTPDALGGVFANAFEGGSPFGGGSVGGADEEGEFSRESRTTQATIDAAQRRRNANAVAKFVCELCGETFTRRYNLRGHQRSHKGEKPYICTFDGCEKGFARAHDRKRHELLHLGVRKYHCSPCNRDFVRLDALHRHHRSEVGQACVKQLRAEGVAFDDQGAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Z6</accession>
    <name>A0A2S5B2Z6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Z6"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Z6"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="523"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="552" mass="59804" checksum="F69A09934511B617" modified="2018-07-18" version="1">MRPYPTSRPASRLQYGYAGPAVRDWDFEMQQGAVESTDQPSHSGPPGWSAPRVGARPPHDYYGQWTGSDAGPAMQAAFRRPPPSWNSPWSSAGGHAPTHTLYGTTSRSQSRLTTDSIYDGWHVGASVAGDEHAFSTAERQGNEIEPDDSTLTNPGWLAGGRHVPATAEFDDLDVDDHGSQWESATPASEYHNPFQGLATYRDPTDWYHGSFSSESDHERYDQRPISMSSSEGRPASSFEVLEGRSAAATAGSPPGAQFLPRPWTAVNYTRLDYSTLPPLPDSPPLSAAAYSLGSPAGRTFSSFAALSLEATDTPEYSSYLGENDMQDVSFIPGERPPFVECAARSAQDTTRFQDLGHSREAPEHLSEAEDDVRVKFEPDSTPDLPPTASGPFSVVRGGAHPSDQIIAGQSSSPLAHTTYQGRGPTRSTRKNVVRDYTSDEDDEEDFVKEESPEWMPAASTSSGRPVKSPRTSRSVRRGSGGSGKSAPQSSYATAERISPITGMPVKAISKRSWPPKDAHKRKFACPIAGCDKTFGRPSARDTHLRSHSGQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B310</accession>
    <name>A0A2S5B310_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B310"/>
    <dbReference type="STRING" id="741276.A0A2S5B310"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="41"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="332" mass="35822" checksum="EC04B2EF035C90C5" modified="2018-07-18" version="1" fragment="single">WTGTDAVSARGERFRQLAHRQPSLAILHKFSETMEGRDQPLKVEIVVYDLLPPSKLGSFLNLIGSGVYHSSVQLSLPLGPTDLDPTPTEFAFGGHDSPGTTGIFSLPAGAAVRRMPGLRYYTTIGAGEAIGSDWEREFTLHGRARTASPKASVASWLPVRNSSSVSLSTATPSESALVASTSSEEGDGRSVVDAAADLIEEGDADDGGLSDGTRYMSRAERRAHRIIEEMKRDPAWNGTKYRLLERNCNTFTHELVWRLTGRKAPSWLNRAAWVATTIPCIVPPGWIDEADEAAPTAESVDIPDPAHMVTSHDSVSIAPTRADKMSLGGSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B360</accession>
    <name>A0A2S5B360_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B360"/>
    <dbReference type="STRING" id="741276.A0A2S5B360"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="447" mass="48799" checksum="4F1534ED968798CD" modified="2018-07-18" version="1">MPKARANSKKAAPSSKKAQLAAEADKPLFQVDTTGNASVRHVLLANQAPGAAKLRKGASFKKPLRSDLILAERSAVPALTSKVVPSADAKAKRVKAKLGEVDRATKDKLKRMTGRDGKGEGLWGVKSAAGDEAVPDSVKEAGKYDAWTPAPEVDADADSEMQKVLDLHSAKTRPVPKAPTSLSKHALLASAQPKSIPIPHPGMSYNPAHEHHQALLASALTHYTGVEEREERGQAAKEAMDEARKLARGKEAWEAYEAEVGSGEEDADLMIVDPEAAAHKELLKRQAAKRKTKQQRNTKLRVTAEMHDLANRRAMKKRIASVQGIKDVEADILASKTLSLEEKALALRARKARLSERGLTRFRSGPSRVPDAPVTFQLGDELSENLRTLQPEGNLWKEWVNSGMRRGRVPVERANEGKKGGKRGGRGHDKNHSMREVEKFAYKNWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3J5</accession>
    <name>A0A2S5B3J5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="8">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="8">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MEF1</name>
        <name evidence="10" type="ORF">BMF94_5661</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3J5"/>
    <dbReference type="STRING" id="741276.A0A2S5B3J5"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:000029">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_II"/>
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        <property type="entry name" value="EFG_III"/>
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        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
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        <property type="entry name" value="EFG_IV"/>
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        <property type="entry name" value="EFG_V"/>
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    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="81"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="168"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="222"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="787" mass="86331" checksum="DA8CEE36988C91ED" modified="2018-07-18" version="1">MLRHAAASIRLQATRSPRSAASVRLAANRLPVAAVPQVVRNGAARRTFVASAWRKDEGKPAPPAPLPAKFTMSEADKTRLTRLRNVGISAHIDSGKTTLTERILYYTGRVASIHEVRGRDGVGAKMDSMELEREKGITIQSAATFADWSVKDSVVPEQDGKYSINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVSGVQSQTITVDRQMRRYNVPRLSFINKMDRAGANPERVLGQLRNKLRMNAAMVQLPMGAEADFAGIIDLVKMKAMYNDGEKGINIRYDEVPAKYLEAAQAKRAELIEHLAEADDQIADAWLEEREITPEELVAAIRRATISLKFTPVFMGSALANKSVQAVLDGVCLYLPTPNEAPAFATNIEAPQDPPQTLSPSGSAPLVSLAFKLEEGRYGQLTYIRVYQGTLKKGSTITNVRTGKKVKVPRLVRMHSDEMEDVDSIGAGEICAMFGVECSSGDTFSDQPGGGGYTMTSMFVPEPVISLAIRPKGQETPNFSRALNRFQKEDPTFRVHVDSESQETIISGMGELHLDIYVERMRREYNVECVTGKPRVAFRETITEPISFNYTHKKQSGGAGQYGKVVGRLEPMEADPETGKDTAFENTVIGGNIPNGYIPAVEKGFRDALERGALTGHQVTGCKFILEDGAAHQVDSSELAFRLAAQGAFREAFPKGRPVVLEPVMKVDITAPIEFQGNVIGGINQRKGTIVDTEIRDDEFTLLCEVPLNDMFGYASQLRGMTQGKGEFTMEYVRHAPVLPNVQKDMIEAHKAFVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3Q0</accession>
    <name>A0A2S5B3Q0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3Q0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="264" mass="28367" checksum="FBC98E498AE9750F" modified="2018-07-18" version="1">MVLSMGGFSVNLIVHDNTLLHPHEQTVTKAGDTHAVYNARLAPGERFTVSWEDSRAEPKPSEGHLWKQEGTGMPLHLGQAATSPDDQTFALVSGVIERQASPVKLTLILTEGEGQDEASDALVTKQTLATFTLLVFAANPATVWTLDPMSDAQTVSGAGHSPRTERKAYDELQIAHLAMCKRAQHYEEESARLYKHVRSSPAAHVQYLDGRLANDPLSPSMRAGIAETRIEAAEKLSQAAAGALDREFAGLMSALGTATTAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3Q1</accession>
    <name>A0A2S5B3Q1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3Q1"/>
    <dbReference type="OrthoDB" id="10526005at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="329" mass="34700" checksum="90ADD55324EB7177" modified="2018-07-18" version="1">MLLHRRSGIGAAFATRELPSPPVTPAKGTATTASATATSANAAGTSKILPELGPAVLDDGEIAAYVEANDEPVRVYYWRDPRVKPVVGLEVYAGFLSVAGEQPWSKVFAIGTGVKTGPGSVWHIDADLGPPAGTLAETPACCVKLDLYRCHLRPGADLGDGYIKTSDVASVDDSAPVCTFRWTYCTPVQLKTLGLGLGNIQPRLSAQQGADPLSIRIAAAGPQPPTNELEPALDFLRHTNRLLLGLLTEEQKRQFAEILGHSYEAQRLLTPVQLGELLQAGQPGLTSSPDTSLSRSEATESPQPLSSVPAKKRKADPLGAVRPRQSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3S7</accession>
    <name>A0A2S5B3S7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3S7"/>
    <dbReference type="STRING" id="741276.A0A2S5B3S7"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="9">
        <location>
            <begin position="401"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="791" mass="83527" checksum="BFD0D8C99F792CF1" modified="2018-07-18" version="1">MLRPRPVVRAASRRVRSFSTPAILKSRATSTRPALAGLPIDIAPEVAQAQAEGRPVVALESTLITHGLPPPHSQSLPKECEDILRQQGVTPATIAILNGRIKVGVESKDLDYLAEQGWLARKDKTIAERLWKVGRRELGAAVVKRLDGGTTVSGTMAVAHLAGIKIFSTGGIGGVHRGAETSFDISSDLIALSDTPVAVVCAGSKSMQILSLIGRLNSLDIGLTLEYLEAHAVPVAGYQTSDWPAFYTAVSGFKVPMRLESATEVAETIAMTDRLGLRSSLLLGNPIPTEYHAVGEELQRAVDQAVAESVENGMARSGKQVTPWLLQRVSELSQGKSLESNKALIRNNVKVGGEVALEYARLMRDATALPLRAFSPSVPPKTQPVSRNEPVRHRTPTPKASVVVAGVLAVDISMVPASSSPLKTTAPGSVKLTLGGVAGNVAGAAHSLLSSSASSADEVLLLAPVAEDTLGDVARGGLARRGMRTDGLVAPPGGRTATCGILLDEKGDLVGGIADMAIAHELEADQRIRSATPEIVCFDGNLSQEAMRGIVTHCSANSVPTFFEPTSNQKALQLLRALEKADRDLSSQLATVPAIVSHSAPNIHELSQLYEHVNFSEHSLYASRDWFDAYTVSAQDLAVRLPKWILDEGVAQMAIRLLSTSMFGTLFVKSGSRGVLAVQRVIGVDRVAEWPRLPRKKGTAVIRSGGVGDAIVLKHYDALPLVEADICNVTGAGDNLAGALLAGLARGCDPALPADLDRLIDLAQRAAVGTLKSGEAVGNHSELRHLLPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3U9</accession>
    <name>A0A2S5B3U9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heavy metal ion homeostasis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3U9"/>
    <dbReference type="STRING" id="741276.A0A2S5B3U9"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="568" mass="58770" checksum="39FD84BD6FB6093D" modified="2018-07-18" version="1">MSSLLRFAQSAIQGANDVGSGGGYSHPAQHRHEPDLDAFADLEGDSDSDRGDDDGYTPTSIAAVSRREANLNAIASPSSSSSAAAAAAVRQQRAAPLHAHGGLPGGYDFEPQVERPRPTPLAAASARSSMSIGRSASNGALSRSRRASLSSQRFREELAGRYETASGEQYGQPAAFAVWRGLVNRLRGTAEGGGGGGAANGGNGTANGEEGHGLLFSQDDSEDPSDRDWPLGRAGDARDRNQYPPARDPHLPLPPRAPQFAPPPDVLSAGASDPPAGTSSTAAPRVVGRGQGHDGVFANLAAKPDNPNGLDIVGEGPDKEEILPPYEAAQHDPSPAYWETTVVAPSGPLGPDDILVDGMPVGNVFSFAWNLLVSMSFQFVGFLLTFILHTTHAAKNGSRAGLGITLIQLGFYLKQRSDGLSAAPGDETGLNGSLGPSESEQRWSWWNPADQPTGTLPDGSTPTATLGGGVFGSLPTQVHGALAGMLASSDGSSATPSGFPTLQGDGASLEEVQRMGEAANEWMAFVLVTIGSFLLIGSCLAYWRAVRWARAVRAGQGPGNDAESVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3V0</accession>
    <name>A0A2S5B3V0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3V0"/>
    <dbReference type="STRING" id="741276.A0A2S5B3V0"/>
    <dbReference type="OrthoDB" id="10633845at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="708" mass="77738" checksum="AB5FA19B7E8133A8" modified="2018-07-18" version="1">MGYLDHAAPASRSSVSLVFLPARAAAVAMALSSIASTVSLVLVIKVVCAVADLDGNDFALVTVDGVLLACVVVTGIVIIYGRFRPPSETHLWRCVGQITSYLTFLCMLTTGFSISVITVVLVPLASCVDDECSHRPLAVKAICALTISLVCLLALAGLVVYDLRRTRPRAQAMIYDSEARQALLWAEHVRQWDQDQLDTEQAMVARAQQPYDPAEEWVPLSARTPPVSDRHALLALPMWSPSSSTPTHFAPEARQGDGPLVNFSAPTLAEWARGSQSGQGRPAPPLTEMHSVAHPESHHHAHSKHSAHHPKHPHGGHSDHAAQAEAKRRKKEEKAKRRLHEKEEKRRRHRAEGLERQAAVKAAREAHERRREIVAQRRKAEHAAHQKALHDLHESRRKRKEAKRKARQEKRNRKGEAKPPAHTHRAPSGREAHKKERALHGHHHTHDGSRHHAKHHSEPAHHSSDPAHPHHDTAKSSHPPSDHPEAHATSTPTPSKESKAHQGTPKKEDPPEKAEAKHRHREHHHRHIHGLFHHHHSEADASEAPPKADHAPAPPPSPPSTTSAPVQHRTRSHTPASAPAPAPEEPAETVPSPAAVPHRKRAPARASPPSDDSSEESTGDEGAPVVRPRLRVHPRSASQPRRPSQRRGHDGDGSSNDSTISESDAASTGESTSTSDTDQTESTDDEASHHSRARPSPWHRFSLHRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3W8</accession>
    <name>A0A2S5B3W8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3W8"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="524"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="637" mass="68399" checksum="B0EE02C4DDE81D4F" modified="2018-07-18" version="1">MGVPVAVGVIVGLAASFIQSLGLTIQRLSHLSNEKLAPDARKRDWQRPLWLFGLAIFLISNVAGTLFQIGTLPLVVLGPLGAVSLVCNALFARLLLGDAFSIQLAVGSALIATGATLVGIFGTVPEQTHTLPELVALYRRPAFLVWLAVLSVALSSAVGTAHVAEWRLERRLADMPPGTPKLARRRQSSRRRTRRWSHPSPTASATTAHRHNNGTGASERAPLLPPADADVPPAKYREASTRFATRIDPVRPRALEIPPPVTAPTPPSSKRKPVPLDDVLELADRTRLWLAIAYGATSGSLSGLCLLFTKTGMDLVIQTLVNRNNQFGHFEAWALLIVLLVWDSQKISSSCMDRRLTIETHAMQLSYLNRALRLVGPTLVCPTAFCFYNAASILSGLIYYRQLDALKPLQGVLIALGSAILLGGVWIVSVKPVPLPDAQACKEQAGGSTGEREHDDAGSGLSMDEMGDDSAESDDDLVPYRPRGFSIGISAASPGFEIRPSVPRRSRLSLDIAEDDRGELAWSTNSLAAPTSPPGAATRQPALLDSPKTPGGGRRARRSHRRDDSLTGAPYVGPLPPPLPSHSTILSFSEEPDEYPAAGAPQGDDGLGAAPEGNFQNAGGRRESSWWPSWTRRSRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3X3</accession>
    <name>A0A2S5B3X3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3X3"/>
    <dbReference type="STRING" id="741276.A0A2S5B3X3"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="100"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="416" mass="45291" checksum="800F5CE9C91E654B" modified="2018-07-18" version="1">MAAADRANANFGRDYSVDDHAPDGTRDESDPVSATTTADEGDLEKAEKLQEQERTGEERKVHREPRSTYLVRLGRHFLGHRGDRGLPTPVLRPLRHLPPDIETYILTFFGAFPSILIASALSYGLSRISTDSGDGAFDNIPLTVTSFGASAVLLYAMPEAPVSQPRNTIGGQTISAIVGAIVSQLFALNGKFTRAPPDNSVAGGQSWPSLIPVAEAFAVALATLAMQLTGTVHPPGGATALLASYHRTAGPRYTYILDVFISVCLLTLWAMFINNLGRRRYPIYWWSSKKPVNPPAPTPAAPSPPAAPSLVPTGQNRPAVRPGADPTAQIRSWSRSSVSTRIDPAAEVDLDSLDPRRTRSRDDEVFTPQEDTERRWLGRLGEVDEEALGSRDEAARREALQWEREREGRGSVGVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3X8</accession>
    <name>A0A2S5B3X8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear proteasome inhibitor UBLCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3X8"/>
    <dbReference type="STRING" id="741276.A0A2S5B3X8"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="56"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="192"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="44300" checksum="80C4C0934E2EED22" modified="2018-07-18" version="1">MGEDVGSQLPVAAHGSLERRPFASTSSSAPSTGDDNDTTEPLKAAHLDASLPTELVYSLVLNWRGSKQQVTVVESDTIGDLKAVLFSLTNVPPERQKIVGLAKGKLPGDHEEVVKLGLGPGAPSKAKEFMMIGTPEGEEARVAGPSEKDDGDIDYAADATKMKAFMAVQSVRNRRKLKEHAEKLEMNIIRPPRPDKMLLVLDLDGCILDTGSWKLPELATELFARPYLHDMLAAISPFYDVIIWSQTAWVWLERKIIELEMIGPTARGNYHIVSCLDKTCMFSVYSEKEGKAWSHQVKALGIIWANMPQYVPEKTVHLDDLSRNFAMNPKNGIKCHAYKDALTRDNIDKDKELLYVARYLLQLVNVADVTQLDHSKFRKSKLALPEGLSDPLDRLKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3Y2</accession>
    <name>A0A2S5B3Y2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3Y2"/>
    <dbReference type="STRING" id="741276.A0A2S5B3Y2"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="219" mass="24967" checksum="E9F392E68679F833" modified="2018-07-18" version="1">MADMPKHTIYPLSNYTFATKEAQHEELPTVLARLNRLETEFEQFGMRKTVEGLLVVHEHGHPHVLLLQVGNSYFKLPGDSLQPDEDEIFGLQQRMYLRLGPESGVDLKNGGVKAEDDAMNGVGSGGINDWTVGDAVGHFWRPNFETFMYPYMPAHISDPKERKTWYLIKMPERQILTVPKNMKLVALPLFELYDNAVRYGPQLASIPTLLSRIEFEYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B428</accession>
    <name>A0A2S5B428_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000083">
        <property type="protein sequence ID" value="POY71529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B428"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF376">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1449"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="881"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1526"/>
            <end position="1545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1622" mass="169744" checksum="AEBDE4F95A8BDAB6" modified="2018-07-18" version="1">MASPSSEQDDSSPAPALQRTASVLARQLAMAKLTGSSLPPVPKTRLLDPLPTLDQLQARALEQREKRRRRGGGGGGWDPDDDDDGADETATTTRPGLRRENTVTGTGGASVSTLSISDELQREPSRFGATLRRNNTVDSGGTAPFVDLAAAAADNTRPPPPPPPPPAAATASESAGSTPDRQTVRANLIRKLSARRGKPSPSSQSSQSSSAAARVATGDSVPPTPPPAAPLPPPPPSPQPTLPLSLAPPIPSVFRTPDAHHSFPPVSEQISRPDSSRTGDEDENDDDGDDHGGLSASQGLPPQQQEQQTLSEAGPRSDSIATTASTTTSSRSSISTSSGPEVPPSSPPPPLMGNPRTARPLPTFGIAAVEGSGAYRSGGIPTAATAAAADHDDDDDNDFGGGGKRRERGSSASSSVVGLAAAAAAAAAAASGGAATAGTAGGRNRGSDAGSFSFPFSAGNGIESSSSSPRTRRTSRLGSIGLGMFTPLATPVGGGGQLDVGDGDNDEEQAGLTGNANANAYGWTSTFPPRRASVVSQARSSSVSSTSSSSVSLTNTTARRRDGRRDRRSGASGTEESIGEEEEEEERLEDEERTGEAVAAGTEDGRSPTLDGIGSSAADTRRNRSPAGFAHAQGEESYLSPPSPPHHHHPDGESAGSAGATPPVEQTPRLGGGGGGGGGDGPWKRSPKLHQGGVGGESPTLGREVAASSAAAAARGWSPQQQRYFQQVSTATDGTVEKRPFAFSLADYRPVAGSVTSPLEIPPNQNRSVPSPTPNPPSSSSLPDAPVSPTSVIPNPMEALAFPLPPQSQPLGARRSPRIAEPEHDRVDAPRNAATERSHRLAPTLVGSPSLRRSPADSNHSFSSPEASLDPVTITTRREPTSAVSSPSVVTSSPTLSLSSSPASSESSSLLPPLMEPRVTRLPATDLPANRILAKLASILGPTDQTAGTEFDAEPQTRTTAAATTTTTMLDDPPRKLLLHAPVLQVVNANTVKDRYLFLFNDVLVIAKPLIEDHLLTGEPVPPNLDSHFLVKSVVECRQLKLSGDEDSIDEAAAASAAAAASSTSGSKKKHPLLVAFVDRFANDPSRAIASLIQKGGLASDGQTIANLLYRNTDLNRNQLGAYLADRRQKHVLRAYIERFRFAGVRIDDALRLFLMSVRLPYDPVAAEYVVDVLAGMWSDANASTGIDAILAHELMMTIMRLSDALHGGDGPSERFFRDPKPDTPPTVDDFIASFRNADTRAIVPEDLLARIYTAVRRERVELASDNSIFSMTPDIEATIEPAKLPTQLTYRTPSARFTISIPAPDSKFTIKLQGADLQFEPPVLSFARSTTQSFRVTGVALGVRTMVLVKRGANAPRYQGLPLNKAFSIERGFMQHTFQLSFTNHLDLKRKYMFSCRDVESRSRWLHLLRERIAASSSAPAPPTSAQAAAKAVAVQVLRDTLLAPEEPVLSGAAPSPRPNVLAPRFGRPVTPLVPRGRLGTPTRPTTSARSNSVSRLYPVLYRSEAEASDKRPSPAIRSAGSDGNLLSPSGMSSRVQTTNNSPDPANGEIATAKAVHGAFVKSGDELVLTTEQNSLLPLVLSFLNAGLDAAPAPLLLNGSAFQLPPLDGTTAPTPSFVTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4N2</accession>
    <name>A0A2S5B4N2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_5076</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4N2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4N2"/>
    <dbReference type="OrthoDB" id="2534206at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000927">
        <property type="entry name" value="Cyclin-dependent kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="336"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY71716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="454" mass="49723" checksum="9D9FFEF8CBCF3B20" modified="2018-07-18" version="1">MENYERLEKVGEGTYGTVYKCRQLHTGLVVALKKIRLEEEDEGVPSTALREVSVLMELGQSTHPGAECIVKLLDVIHGDDSLSLVCEFLDLDLKRYMDTAAIAAANLAASTSSSGPAATHGLDASGQWVPHAQMQPLPHNVVGRGRSKRALPPDLVAKFMAQLLLGLSHLHSRRILHRDLKPQNLLIDKQGNLKIADFGLARTYGVPLRTYTHEIITLWYRPLEVLLGGRHYTTAVDVWSCATIFAEMASGLPLVPGDSEIDQIFKIFRLMGTPTVQTWPGLAQMPDNKQSFPKWQPADLRKLLPEMDDRGLHLLNSMLQIDPERRISAKSALRHPYFHPPSPKANTLAPPLASPHGHALPSWGRPEMPPPQQFAPSGPPNSSQPTMFRIPAPFQQPSHAGPPIGAGSFGQSHFAPAQAHSHAFSQHRAPEAMHDSPVAPVVGRGEGLMASPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4P4</accession>
    <name>A0A2S5B4P4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4P4"/>
    <dbReference type="STRING" id="741276.A0A2S5B4P4"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015448565" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="68"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="513" mass="55081" checksum="15D87765BC453A84" modified="2018-07-18" version="1">MSRPRRSPAAAAAWLSAFLGVHSGVALPAQLANSDSSLAGCLYNAGLSPVTMAMSDYGSDSAAYNQRLQPEPTAILYPSSHDEIASALSCASQTGAKVSARGGGHSYASYSLDGDLVIDLGNYRNITVDGNGVASIGAGNRLGDIYLALDEQGWAVAAGVCEAVGIGGHAGFGGFGLPSRMWGLLSDQVIGYDVVLANGTAYTHLTRSSDPDLFWALNGAAPNFGIVTTYRVQAHHEPANAVTYSYYYDSPSSSEATDALLAFADFGNLSAPANLGMVATTGTNSFEISGVWYGPKIEFGSVIQRLKDDLPGGYTETVERMSWIDSAKHLAGTDDLSTHGKMLVSRDSFYAKSLMTPSTIPLERTVVQNFFEYLFTSNSSSKWFVETDLYGGRNSYINSVHLNESAFGFRDKHLTFQLYASSPTYGNPYPAYGIPFVQGMYDTLVDGMTKYGWTNDSSSPDGYAAYVNYVDPELSFDEVKNLYWGSQYDRLSSLKAVYDPTELLNSPQGIRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4R8</accession>
    <name>A0A2S5B4R8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B4R8"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="942"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="778"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="865"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1504" mass="157379" checksum="F55FC4B470E4CB2D" modified="2018-07-18" version="1">MEQQQHVEALSPPAAAYGQALGSPSAFSLDNAANDGGNALNLHEYLAGMMSPGAFTASLPQHSSGFEGHGSPAAEAGHHPTPVNFADLLAEFTSAHNAFSPDTTTGPATSHKGGDSSAETTSPVLAPAANGNGDLAHANGPTEAATGQRTAQEILLEQLKALYPAAGPAETGAPEPSTSSQPSPAEAEQPKHRSPRLEASHDAHGIMSAALPNAHAHHAAQAASSPAASNGSGIQLDPNIQAQLHHWLSQSLGGTAPSPAVQSPVPTDAYGAPAYQHGRSASTSAHLPAHLFHHGQQSAAHSPASVAYQHAQSAPVSHHASPLPAFGGPMQEQPYPASGPSTPYGQPPASTSQPLYPFPTSAMPIAIPSFLAQNLPDPAASPANFQAQLAAMQMLVSANAQAQVQAQLQMQAQQQQHHYQQPSVLFQPGQPFQQPPAHEQQPTPLQQASNPQIPFEIRTPAPGTASSSYREADYMFSPLMSPAMTPHSAFTNASSLPPSVGPLPLVAPSSECFPPLTSPALGPQLYRSDGGPMHAHHRNSLQGLVDGVGALSTQLPPGSPNNPTYSSPRVGPSDPALPPPSAGSSRRGASSGRSKTRPSPLIKPTDPTYERRRRKTQTAGSSATTEKRTFSSKSATASPRVEGMTQFAASDRASSAFSGASSHVGTSPGDGESVPSGEANGSSASAASIDTPSPVDLAASSQQFSNGSTGLREAVTIANAVSIQAESDGLMGPPPSRPSSTSVGVTPASLMNFGDTFSLNGLSSLSPAFGASQPQPPFDSVSSALSSLQNSPALLPEAEEAAAPLLAMPPAITEESFRAPAQPSASGKASKVRKTPSARASPALKPVDSKGKGKTIADKASNGRKAASSKPAKIAPSPKIGPTRGNMTPDSLRATRGSGKSKDDNDGEIDVLGLPPAITADLTVESLEASLSKADKEETSDTRKSSHKVAEQKRRDSLKLCFDELRRILPPILPYTDEQDRRPGDGNVGGQRHGEIDPQHPNKGVSKVALLRRSNEYLEILRERIDRRDRAISSMRSHLSQLRAQFGMDELDELEEEVPGLDLDLDNLDKEEKRAGNLAFYEDLDFDEKVALGEIDDDDEEEEDSRAISASRAERYEVIAGLVMLLLFAVATLLYFRQQEEAVIDSPAVPFTSQTSTDETSFGGVDEDATEPPAQSTSAPSTSASLTPAAASSSASSPASGSSGPYKLVTSYQGTSFFDGWTFWDQADPTHGQVDYLSRDAAQAAGLISTTAKSAIMRVDNKTKLAPGAQRASVRIHSTKAVPIDSIVIADFLRMPFGCSTWPAWWSNGPNWPDGGEIDIIEGVHNDEVNQLTLHTKDSGCKLDSKPDITGKPVPANTDCNAHNNGNTGCSWAETASASYGEKFTAAGGGVLATLFSEDAISIWFWSHGGTTLPDNIAKGAPDMSTWGKPSATWTKAACDIPKYFQDQTLILNTSICGDWAGAQQVWSLACGKEAPTCSDYVSDASHFDNAVWEIASVKVYSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4X2</accession>
    <name>A0A2S5B4X2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="7">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5193</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4X2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4X2"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="13">
        <location>
            <begin position="21"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="346"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 11">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="49"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="229"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="400" mass="43853" checksum="2958070B66681A18" modified="2018-07-18" version="1">MATSSGKPAASTSHRVFPHLKPTDEPNLDDVARLIKDGKAKRIMVMAGAGISTSAGIPDFRSPGTGLYDNLAKYDLPYPEAIFDVDYLEERPEAFYTLAKELYPGNFRPTPSHYFFRLLQDKGLLHGLWTQNIDTLERIAGVEDERLVEAHGSFATAKCLRCGKVYDKDDIKPQIMLGEVVRCQGQGCKKRKDALIKPEIVFFGEGLPDKFFSRMNDFASCDLLIVVGTSLSVGPFNSLMHRVPSSCPRLLVNLESVGEIEHARSTVGFDFEGANGKPIRDVRKLAKADDAFEELCELLGWSAELQRIRREGWRALDAADGSNTAEQVEPQAEERQTEVLEAVEAAVDRSSEQASTSSKEVDELAKGVASVELDRTGDRKDNTAASEGAAAPGEDKKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Z9</accession>
    <name>A0A2S5B4Z9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Z9"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Z9"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF169">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="469" mass="50964" checksum="984E90E3EA19C34F" modified="2018-07-18" version="1">MTWDGSLTIAALQSAYDSGATTPAQVVETLSRRIGNYAAKDPAVWIDLVPLDDILVRARELEQRYAGRTKPLLYGIPFSVKNSIDVAGMKTTAACPSFAFTPKETAPVVQRCLDEGAILMGTTNLEQFATGLTGCRSPYGYPRSVYDGDYTSGGSSSGSAVSVGAGLVSFSIGSDTAGSIRLPAVCNGLIGMKPTLYTVSTRGVVPASKTADCVSVLATTVADARTALEVIRWYDEQDTLARPFSMFDNLTAWPSEVRYGLPPQEALDSLCPEYAQVFEQIVSRLQDPQTHLASSDFDYTPFELANGLMYGSSIVVQRLVSFDDYLKQHGTSKLHPAVAKIFDASKGFDAIQAYQDQFKQLEYKRLVERQFRDNIDVLIVPTTVQHWKVEEVEVDPIGRNAQLGRFSMFVNLVDLCAIALPTGSWTNAAGKEMPFGITLIAPAGRDEDLMRLAERLLPILPAPPARSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B530</accession>
    <name>A0A2S5B530_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_5238</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B530"/>
    <dbReference type="STRING" id="741276.A0A2S5B530"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="143"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="486"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="753"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="802"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY71877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="882" mass="94430" checksum="7540FDB8E999C4C9" modified="2018-07-18" version="1">MGIGGLLPLLKEIQKPCHVKEWAGKRVAVDSYVWLHRGAYGCAEDLALGRPTVKYVNYAMHRVRMLKHFGVTPVMVFDGGLLPSKMGTEDEREKRRAEALAKGNAFRAEGKASLAREAFVKAVDVTPAMAYQLIKASLLNALRAEGIEYVVAPYEADPQLAYLEKSGFVDAVVTEDSDLLVFGCRNVLFKLDGEGNCVSISRDDFSKCREYNLAGWSDDEFRHMAILSGCDYLDSVVGLGLKTAHRLLRKYKKPEKVIQFVRLEGNLNVPRSYLDDFRRAELTFLHQHVFDPLTKSLTHLTPIPAGTTLEDLPFIGPLLAPDFALGVAQGDIDPITKERVVDLVPSSFAATNDTPKKFDANGSRAKAPKAGTPSGGTLLSFFSRQAGSPAVVNPVKAVKAQARVTLVGSAKENKPAVTQQEEPARASKFFGAGRGSKVELQKSSTAAIVPPVMHEPDHEALSDDFEAEAALRDIELGFDLPSEAAEIDEPEEAVEERRVSPAEPAPPTHRPALCGIQEQAPDVDGGSVQSEAGGIVVPVSPPPTSEALVETPSPERQKVAISASGQSDVGVSSPADSNVAQAGWPTPELDQSPGLLSSPITPRNGFSISPPPPIVKEEAAPAPAQTTAAPFVTLSSDPIILSSDTGSCAEQATPRPPKRSPRPPKQRKSPILSAKGKLKTAPSREARSKTVAVWEDTPGPRAASGESAPKTSASKRRKQTEVIVDDDEGVSEAVRSVAASWRAKFMLQTAVKSTPRLLAPVQPPTPASPTNASRQKGPRTVAPPGKHSSATASATRLPLSTLRANTSLKRSATTSAVDENCRPRGDEDLAPAKKRRTVSALDCTVDRSLIENDVVVSSSSSPVPITNPRLLAFRFTGTVRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B566</accession>
    <name>A0A2S5B566_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000069">
        <property type="protein sequence ID" value="POY71918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B566"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="581" mass="64008" checksum="44213EE7B5903C77" modified="2018-07-18" version="1">MATASSYHQFSRGRSSGNERATGVGVPQQNGQQVGSSSSAHASVASRLKPRSEAGDKSGLQPIPTVTLLSLPDELLSRIFGLVHAVYQRDKPGMPPIGALLISKRITAIANRIWMRVLVAPSDFYHYRNDAYFAGVLSRSDTSVYTQEIDLSLGGIYFHLPMAVVARLFASRKLAVHYPSGQAIVPSIRAAWGDLVEHLPALTDLELPMIDEPLGRVISAVAKERSLCLHGAWHAYDPALRLSNVTGHVVRGPASPCRFAWTSAKRIELSSESFESHAAWTIIGDLEILEEQAAPLPLEILKLDLDNVAKPVEFYELWRNSTFAQICGLLKSFPNLDALTLDTLRYYASAPSPAATLSDRARFTQLIESTELERIASFPFLPALIAFLVPTKQSATPFPLKHLRLEICDRALISPAYGQLLTTLLETICGIFSDEGIQNLAIITRRAPNMAGTSLVPSVTQLTVGRRHVLSEKAQLEKLRHFIANFPNVQDLVLESLYYGASTAGLHLALSSAQRFQQLFADRQMQRAIANPFLIALVASLLPTRVLRLIVRDKSLPGCELRFTRPAAEREFFGVEKWTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5D9</accession>
    <name>A0A2S5B5D9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5D9"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="113" mass="11813" checksum="B77F83B516FBABA5" modified="2018-07-18" version="1">MALTSAKLPAPLRLQARPSSIRTLSTVEAHAQLAAFLASDASTLVAGAAGTGATRASIVRLVKGLKETIDAKPNVTTATESRVKPDLDAAPKKRRKSEGAPGQKDKKRRKTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5F0</accession>
    <name>A0A2S5B5F0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY72010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5F0"/>
    <dbReference type="STRING" id="741276.A0A2S5B5F0"/>
    <dbReference type="OrthoDB" id="9995831at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="463" mass="49509" checksum="EE894E125A418965" modified="2018-07-18" version="1">MPLLSRTPSYSNGPAPRTRRGSHPKPLSMAMPPAPPSFSTVASGPGRPPTQHLDADEPDLFHIDHAHHLTQDDDGAASTSPQLSAAYFRRAVHRVHDVLYGGRGKDRTEIDNVVRELYDTGAAFENPLTLARGKPAIADMFALLALVPGSMWSEMGEVTHSHSAFDGSRLVVFSHTLHISLLSFLERESAPPCGGGGRGGGGGGSTATGGGRTPATPSRQRSYSFFSLPGTPFPQTPSAQYGDDGKSEAGGGEYSPGIFSKSYAAMTARDRWPAASLLRALSPRAIASSLATLHLKLHTRLVFNEEGRIIAHEDMWGLKEIVEGVFPLGAHLYSVNRQGLGWIASIASRILVPKPLEAATTSAATEEVTQAAAKRRLEAAWDEECPPDRGRDRDRAAPTTTAQDSLARYHQALMMSAASAPQQPHRKLMNPFPAYGTDNPDAFGAALGLDVGQRAKPTTMEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5K6</accession>
    <name>A0A2S5B5K6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5K6"/>
    <dbReference type="STRING" id="741276.A0A2S5B5K6"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="353" mass="37952" checksum="95AD2C0F13563765" modified="2018-07-18" version="1">MPALQRPEPPAALIEALKAANVPVESFADACAACEDACDDHDEDLQYPSGFEVDLDSQMLGELKPYGRQILVSTGKSDWIREVTDDDKSIPGLVKAEYEKVEKANGGAGKDGLFAKLGNKVFGSGASAQKGKEVEVPGVHPSAANPPPDTAVSSRLSILSASFISSSHHGHRESVISLPDFKVINEVEATSASVEELVKRYLEPSIGRAGSSVVKGELQSWPLPYNCFHHHLEKHGLHVDERGDDLAHGPPIEEWEGTEEEKEVRLRETLQGVKTDGGSVGLFKISHIGGHRYAGNVILYFPNGTSVWFGRVTPADVGVIVDRTIMQGKIIPELLRGGLGLSGKNGPKGVLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5N0</accession>
    <name>A0A2S5B5N0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000059">
        <property type="protein sequence ID" value="POY72093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5N0"/>
    <dbReference type="STRING" id="741276.A0A2S5B5N0"/>
    <dbReference type="OrthoDB" id="2528938at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1018" mass="107527" checksum="EDC8A9DB3FF947FA" modified="2018-07-18" version="1">MQSNYDDFLYGTGGGRGSTTLASQRRRGPVDLATGAVGPPHAALPPLPSAIPSVAPALATGTTAPLRLPALVPSSSADSPPSLHSHPPRPRTRGESSPSLAGTLYAQQDRGVNPFDRTPSSSSGSVQSPGGRPRFDSQASMMTTGPESSLPQRHNSRGSEARAAPSSKSVLTVALQRAQSAVLLDSANNYPSAIAAYSQAVRLLKEVMARVEDGSREMERKLSDAGTARRPGESEDEWGRRRAKYERKEKAKLDEARRLRVIHDTYEDRIRMLVQMGTPLPPPSPSFGSASSFPSSASSFPPSPDPLRATNHYRQPSSPLDPHRPLASHPYAYDAIASTPRTAAFAALQDGDGQGIGAAMLQVGQAGNSGVMASSTNEPVLSRLPVVTGDDRLSPGLEHPRQPTRPLSFASDSTAIAIARTTATDGAGSPVGFPSPVPLSPLDPMLALPVEVESAAPGPDGGTFALGDATMQPHGFTIAGDDPTVQPSRRHGAPTMRRGQSFGGDGSFRPVADGRPIEMMRGYSTGSIVPVRRGSSISALAFVEEGGAPVDIRPRPTRNASLVNPTTQDGTISQRRHHQQGSLEASIVVRAPSTDTERATPVDDFGQPRDSAKHESWATGSLPARLRSLSTSTGSGSGSRRPKLPPFEEMPVPGGHRTTLSGSSSGPPSRKSSVPTPTSLNAPSLGAPSLGRSPSASSIGSSASSSYPRRRVRPSFSGHASSQSVSSSGVYLSAGLANHPPPDATSREATLAIHPARRPFHLMRLVLSTMPPSAGGYVSEKLFIPAQIWTTSAGAKLVALETKVRMLDLLGTGLDALERAGRGLLLVPTASASARAVARQEADRFARELDGFEGLTEGVQSTLVRKSVSSAVEPKTGRKGSTASFASWSSKLSQSLNRVTNGARWVSIVRVRESRVDPSPDSLDSQAAYVEAIAKILKQAQFLDEHLALILPQPMTPADDTPYALLERSTRQQLERSLRRTSEFFGQVLCRFVLQDVGVLLDKCGWHVKRGGAWLSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5S0</accession>
    <name>A0A2S5B5S0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribonuclease T2-like</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BMF94_4921</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5S0"/>
    <dbReference type="STRING" id="741276.A0A2S5B5S0"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015473415" description="Ribonuclease T2-like" evidence="17">
        <location>
            <begin position="19"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="18">
        <location>
            <begin position="304"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="POY72051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="424" mass="45342" checksum="78EF664B4B079BA7" modified="2018-07-18" version="1">MLPLSLFAAPLLVSTVAAEPTQWLSSFLNAAEQQAHTIFGLHACPAPFLLPESCINGASPDFPGLDGCCTNVPGGFLLQTQFWDTAPSTGPNNSWTVHGLWPDRCDGSYDAYCDPSREYTDIRGILQQNAPSLLPFMDTYWKDGNGDDNSFWAHEWNKHGTCISTLNTTCYGRAYKQYEEVVDYYERTIELFKSLPTYDWLAAEGIVPSASQTYTLEQLQTAARKHFGYEAVWGCTGGNKLDEVWYGYHTRGPIAGGKFIPTSPDGSKSSCPDTGIRYLPKYAPSTSTGSGSISNSTSPYGNSTSAFFQGVVNGTEQGCLISAGAWFTSGTCATLHLTPASPSTDLAAGFTMTSSKGPCAVASGALSCAAGNTASTFTLDSNKNLVYQGSSSFTADAVPPANVKETVYTTSDHAVQLTLKCAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B661</accession>
    <name>A0A2S5B661_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="2 8">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="2 8"/>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B661"/>
    <dbReference type="STRING" id="741276.A0A2S5B661"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004112">
        <property type="term" value="F:cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012386">
        <property type="entry name" value="Cyclic-nucl_3Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07823">
        <property type="entry name" value="CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="569" mass="65564" checksum="A7C877416F9C58C0" modified="2018-07-18" version="1">MHGVRRQRRAPPSEPEDAVQARRDLEQRRIGEYTQLCDSLYAKRASGDADDGAFDLTTRVLTLNPEFQSAWGFRRRILQKRLEQDSDDAARQNRLEADLQLTNAGLQRNPKNYSVWEHRKWVLDNMPAADWNGELMLVELYLKKDGRNFHTWDYRRYIMANLLVDAQDSATNAPNDQARKSRPTVQSELAFTTRKISENFSNFSAWHYRTKLLARQWSEKGLTETDPERVASLDQEFELVRQALWSDPNDQSAWLYHRWLIGQGTQKRLRLEIADCEQLLEEEPDCRWVLDSLVTYKRKLALQLEQEADGATGEADHLKMDCIGMLQRLQEVDPMRRARYADICYALWLRPDDDQLDEELSRLIEHLADQTGDGPTFLPHVTLLSGISSDTPQDQLEEQLRAAVRDWASDAPRGLELCLEGVDTRTPRFFQFMFAHVEANAHLLSLRAAVRAALLPDQKDKPDDYMPHLSLAYGTQGAQELIDSLTLNEGASEDTRATRDGPRRWEHTGRTFRVTGVELWACVLVTCDPAVKQILLQLDENSGRRRFIISDLDETHVLISPDAVERVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6I7</accession>
    <name>A0A2S5B6I7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6I7"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="100"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="849"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="913"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1013" mass="108393" checksum="D0F404239DDD427A" modified="2018-07-18" version="1">MTTDGPTPVRLERLANEEDDDNGDVDSAAAPPRSGIASSRSAATFPPASLQQPQASTSTSLLSPATPGDGLAALSQSPTAVTATMTRSRSGLGTVDAQVYGVICVGFDHTLGPNIEFAYPEHLADNADLNKNLPFLALPDGAHARDEDYSYFHLLVPTIAPDRTIFGISCNRQISADQLLRKGKEVTRSTVQKAIVILASKPVFGALRDKLGVVTRSFFAQRNFDDKSILVDLFNSFEAAAHAAAESAEAKRRESLARARAEEEQDERGTAGTADRKGKGRASSEEESAPISVVEGAEAAQIPEGTALPASPASKRSSRQRLSLRLSGRTLDAAATADDEEPPESPPPEEKERAAEESGEMYMGTSLRELVYRFRFKTLMLLKLLMLQRRVMFYAANTPVEQLCTFQYSLVTLIPALLTNLEDSASPVLDERAKRRKKPSSLRTSDKYSLIRYLGLPLDVFGKDSFFQPYLPLQQIDLLKTRSYLVGTTNSIFQQQRDCHIDVLVNIDSATLDILNPKLTALVTLTAADRKWMDEIVTLVDQSWNAADPSRPLGQGFVGSDDFIRAKFEEYVCSLLACVKFGDFLSKERGERVEMLLSAPELESYNPSSFNEAFIKAFKHTAAYESWDRMTDEVIFDLVEPKHPMEGKTNPIEDVGIRLVHGLHDSLQDVTLPNLSQLPGNLNLQNINLAPLPMKARERLSKGWTSGWEAMEQLRDDWNKRVSTGSLGDQEVYAPNAPPGEASLGTPPIPPTSPQVGQAFFAGVDVAKSGAASLATGIGSFFGSQARKTSFFGNGSGSGTVPTRASLAALSTDPDGGVGLVAPVVQPKLSTSPGGTSFLRPLSTAAAATVQASPPSRSTSPVPSSSATVPESAFSPSPAATLASKQQRPTAPAGIGGFFGGLRRTLSPVPGGEPSSAASTPGTASTAGESGFGTPPLSSFLGVGGWGASAATSRKPTHERASAPSGPPLRARDIMGDLGGQADDSDEEDQHRDSLEADRERERTRRKLEGLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Q2</accession>
    <name>A0A2S5B6Q2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF292-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Q2"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Q2"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33754" checksum="96BE30D413CE503C" modified="2018-07-18" version="1">MPPPAAWQPARARVQLKLSRERLRLLQQKKTQMAKQTRREVAALLDKGKLESARIKVEGLLAEDLYVELLEVLELYCELLLARFGLLETVKEIDPGVQEAVAGIIHAAPRTELREIHILREMLMSKGGRDFAVACIDNSDGVVPDRITSKLVIQTPPTDLVDLYLFEIAKAYSVDWVPESLATAATPTAPEGTIPAATDLSESNASGPKQNNGDGSARVPLASPTKTHAIPPFDTVLPETPPVDPARANGATIIRTNLGADEAKSAVAKSTAVAAPAAAVAPAASQPAKSAPAAAEKEDDAFEALQRRFAELKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6S0</accession>
    <name>A0A2S5B6S0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6S0"/>
    <dbReference type="OrthoDB" id="6259853at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="492" mass="52548" checksum="632D667224B88883" modified="2018-07-18" version="1">MNARQIQTLSVSQLCTRFQSRASSAPADLQPLSQFADLLKKASSNTAQQQAEHAKQERDRLAAKKAAEETEQRRQAELRRLAEDRRKEREDRERKEQEAAARKQKALPKTTNLWALRQERKRLGLDPDGKDDHLIGSAAAPEAKPKSYKELLSKANSTAKSSASAKGKAKEKEPAVLSRAEKAQRKQAALFNDDEPSSGAFALAQSSRKPASSSSRDSPAASAVPAALKRTGSADSAHSSRNGSPASASNGSKASVAGSSKLASRSNGSGSKGAAAPAPSASGSARSRLAAQVTSLQQPQKLNVVKRDTRTIEEIERDMKMRKANANGGGAPSSAKTTDSSARRPLAGPSAALNGSTRTKSDSGRSGRGESGSTSARRPRSPSPSSDSDDYSSDDDRPRKRSKGKGGNSSGLRGDQRNAIWKLMGRNREQDLAREQAWSGSDDSDMEATGEDVLQEERLAARAAAREEAAELARERKRVEEKAKRKLGQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6U1</accession>
    <name>A0A2S5B6U1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6U1"/>
    <dbReference type="STRING" id="741276.A0A2S5B6U1"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="273"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="461" mass="48827" checksum="A64155358A2B88A2" modified="2018-07-18" version="1">MLSRSRAATRNVSHLLVAGWNPLAPPGRSSAAQSGQDRQSVSNPTLATAPLATWLASVGREQDVEGGYRVAHVAGGAGHQVVSYKNYEGTDRIFALGRNEAGQLGVGFASQEGTRGLVEGFEGEEVLAVKAGVQASYILVRDEDSTVLYSIGNLARGRLGHPNMTSHFEEAEAAAGDEPRMHVLPRATAVRLPPGAGRIKQIESGFEHVLLLTETGEIYGTGCNTDGQIGLGAAEADVFGFTKVDLPAEIAQEGGVARISAGADTSALVTASGRVWTWGNSEYGQAMHARKIDQILRPLEIDHSFLPPSRQLVDYRCGGSFALALDGYGALGLGESLVRSEKPRRVDALEDQGIKRIRAGYGYAAAVRDAGADSAVYSWGLNSIHGRLGLGMLASSRSFDSSKPPAVAMHVYAPQEVALPLRELGLDGSVAGREGVQWRLGKVELAMEGMWVGLEVDEDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Y7</accession>
    <name>A0A2S5B6Y7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Y7"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Y7"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="941"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="954"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1062" mass="115227" checksum="33ED94D049C48540" modified="2018-07-18" version="1">MDRNQLLQLLQATLDPNPNTRLQAELHLAQATRLAETALGLAQIATNQQVDVPWRQAASFALKKYVKEYWSPFFSTFKGPEATTVEVKEQVRRLLYGGLADPVRKIRLACANIVSLIAQPDWPEDWPTLMDQLLSLIRSPSIDAVEGGMRALSDFVSITLTEDQLLPVAQDMLPTLLAILGAPETYGPSTRARVVLIFRQCVMTLFTVKDEHPVAVKAAVGQILPVWLDAFQQLLSTDPAAEMQATGTCDCFAVRTAVFQALEVILNSFPSTLKATLPTYLSAASSHLAALSPVYESACLSNSSDYSLPSTSTGEEDSDVSSDLGTLVATVLDFVGQAARRKSVRMVLVEGRQPSAALVDFCNKAIDCARMTTDDEESWATDPNAFVADEDDEMMSAYNVRSAALDMTMAFTETLGETGFAALQSAFEQAVQKAEQRKAAGDEDWWKSCDSSLAVVGTVSEDLIEHVQECQEEGKKPRFGLEAVFEGVVMRSVNASDAPFLQGRAFVFASQFTEVLPVPLAKQYLGAAIQVLDSSEAGVPVKVSAVRAMTNFFRHLKESVDPQQAAAALAKLLPLLPQTSENTLVLVLDAIQSLLRVGGASLDAATCSSLIRTVLQTWFEKPEDPLLGSSVSDIFAALSASPSPVVQSALLDEALPALVSTMNEARSDPSSIRAAAAVDITSRIFSRFPTPLPARAFDCVAATLFELLKSTEDRDITQSGLDVVTTVIRKDVGQLLDWRSTSGESGLDVVLSIVARLLEPSESEAGGLFVGDLVIHLVRKAGSSISPVLPGLLQAFVTRLATAETAMFSQSLLLPFAYLLQHQSETVLSLLESLTVPGPTGQPPRPALEVLLSHWCDFANDFQGFWNQKVFSVAMAQLYSLASQRPSLQQVQVKGDLLLTAANSNRIMTRARARANPDQFPPIPFPAKALKLLLHDAQTATPAANGDKAAADDALSDDEDDEWADEGAEFTSGNEKDLDFLSDMLASGGFNKYMTGDDDDDDEEADEQDLQDDPIWQLDLHAHLKSFFHQAYEADQTGFRRLAEIYLTEEEKGVLTQLLQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Z2</accession>
    <name>A0A2S5B6Z2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Z2"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Z2"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="332" mass="37075" checksum="B88256086F60EB5F" modified="2018-07-18" version="1">MSLPTVQFAGQSVGKIATGLMRLTWAPKQTPDEQAFELMRVAIKEGATFFNSGVFYGNPPDSTSNLQLISRFCEAHPDLKDKFVLSVKGGITAEFAPNGTIEFLREEVEKINRILKHRKMDMYEVARLDTKTGIETVMKNLLTLRDEGHFKYISLSEVAAATIRKAASVGPVSCVEVEYSPFTTDIERNGVLDACKELNIPIAAYSPLGAGFLGNSWKSKEDIPEGDHRRHFDKFSDEHFEHNMQLVKQLEEIAKKRDVTAAQLTIAWVGQQWEGVLPLPGTTNPDRAKQNIAAGKIRLSDDELKQIRAVIDNFDVKGVRYAKGRMSENLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Z9</accession>
    <name>A0A2S5B6Z9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 14C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Z9"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Z9"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070453">
        <property type="term" value="P:regulation of heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF43">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="10822" checksum="51457DCA5E091A2E" modified="2018-07-18" version="1">MDNDTRFGFAASSLIALGGLIGFLTKQSLPSLMAGGGSGALLAYGVQRQRANPRDVGLIVGVSALLVVVMGMRFYRSRKFMPAGLVSLLSAALLYRFGQRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7T5</accession>
    <name>A0A2S5B7T5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7T5"/>
    <dbReference type="STRING" id="741276.A0A2S5B7T5"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="71"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="906"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1144" mass="120469" checksum="B425E212C18E331B" modified="2018-07-18" version="1">MSAPIDFRAEAPDSLDEPDYLYSHGGNSYGAGKSPRSFGGSWGAPSTFGTPGRSAAALSKGKGKAKEAYGSSPIASVPLEIIAHIFAHLPPASLGTCQLVCKAWHDVVVDEGSWRTAFETYYDVTPTALGRRLEPASWRSEYIARVSLMRQWHRARTPTLIHNPSLGAISFMHVHLPASSSLPGNSNGSAGTRTPNGSPISSADPSSLTATPLLSLSLSLGAAVHSSPFTGKVSKRPLVASPVDHLDRPVGLPIVSVTSFAVSNDGTRLVWGMRDGSLRFANSAPAGGGRGVAGGVVEQGEVRSLDEAHRPGSAVHLVAFSDLAGTGAGRTIRTEAKQRPEVFVTAAADGTVAVWSLSATHSATGVGAAPGAPANGARERPPPATKLWQARWDGALDSAVPSASTDGEQARLRRVKATAIAFDSGWLGRHHGRPASLAIGRSDGKTVVWPDVKLDEPAAVSSASEEDALVLPAPEAGKAIDTLYLDLAGTVGSQTRLALLTHQVESSSFSRYLLDAASCERTAFGHPLTDTLGPLTAFAVDFNDAPPAPSSGPATPAVGKIAFPPRPAGLSSASITSSNGMPPLSRSSSAMSLPPFQPISHDVGSRFGRRKYVAAGDAHGRVFLWDWEAQMEEAERDRGDVIPPAAQIQGLEIEGGATASRITALELTEAGVFVGGLDGTLRFYSTLGTSHSLQPPVRSFRDRTAPRHPSRMLAQGLVAEDEEERWLVSHIRANREAVVAAIGGRVLAWKISSNEVKKKGLKASGGRLSARQERFKANMDLQYQVRESLSALSAESAARLERHQEEHRLTTEFGLPPTLENMTEQEAVAFAMMLSLDEQEQQHQQEAADEEGWEQPPEDWLEGDELFLDEDLDRAGPSGLPSRGPNMVAEDDDDRASSATSRGESRSQSLSVSPSPYLRGASLSSGNSPSLSPRNVSYTWTPISPSLRAIGSPPSAHNPHGKVQVSPRLGPTYGSAGATYSTEAVPDMSPELWPTACSPPGSGLHASLASRRTSTGASSPLGPTASGVPPISGTSSSRAGTPVRRGWSEVARSASSTPASSNSPSLSPTVAPRASAAWPSPPSAAKLALPLTGPGTGSLLSEQLRYSEFSAQQDEQRRRQQQEEDDVRYAIELSLAEEASRLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B834</accession>
    <name>A0A2S5B834_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B834"/>
    <dbReference type="STRING" id="741276.A0A2S5B834"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49299" checksum="CE48FBA8F66E9593" modified="2018-07-18" version="1">MRTDLKLVGQDYSWCASIFYFGQFAAEYPCIWLLHKLPIRLFVAISIIVWAVVVACQAATKNYTDMLVVRFFLGFTEAAVSPAFVLMTSFFYRKREQPTRMAVFISFNALAQIVGALLLYGCGSIKGAAMEGWRISFLICAALTIVVGAYFLLMVPASPATAWFLTPEERIVAVQRVAQERASAAHSDIDMRQLKQTLVDPRFYLTFLWAAMVCITSVVTFGSIVISGFGFTPFKTLLIGLPGPAIQLVTIWIGAIAIHFFPNHRGWTQLSLLLVPLLGVIMMRALPYHQKWALTGGYWLATCNSSLYVVNLSLIASNTKGHTRKTMFSVVYFIGYCVGCIAGPQLFLSKEKPLYRTAMNTIIGISSGASADLIRMEADLLFSAATPDAVYFVAMLAYREICRRENNRRDMLAANGCVEAEARPAEKEDNKSDIDDLAFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B873</accession>
    <name>A0A2S5B873_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B873"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58403" checksum="C4A653DE85E65D97" modified="2018-07-18" version="1">MASTVLAVPDSLATEPVMLTTVEQPDRLDSLLQDARAWQQELKDDDADDDDDLEEEATTTAADRTDYAAADLLPPEVVEMILHPQFEGCTNFKDKLRAMARLASVCRAWKAVAEAAAFASLHLHANADDMLARLAAPEGLLKYLPLVQTVDLVENRDLGALYERFVGILRNARLGDTATGEPTAPTRKQVKAMATILAECEGLLALNAREYADSVMQLLVTRFRFAELWPRLRSIRISWQFPLSAFYQMLVQISHIDTLESVYLYVVPKSRDSEPDALARSQKLFGRVQRLPRLQHFGVETYAEVPLFCDIVFQLVSPRAHLSTLTCRGSIPPGWCEKVVQHCIEIDVLAFSWMRAGADLRTTLLPQIPMLGAIRIRKLTLTVRPMWALVDPGERMPSVIALLNSLPPAIETVDALTVLGGRVTAFARDYRLNVIVRRPVIKAYKRNQAGRPLANSTGRLLKQIVYVHAEGLAPPYTALGRFCKTDDVDGELGEWHRADTGETLDLANRPAEELTPESLTGAMWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B892</accession>
    <name>A0A2S5B892_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B892"/>
    <dbReference type="STRING" id="741276.A0A2S5B892"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="3">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="672" mass="67499" checksum="2CD0CCB22E6C7C87" modified="2018-07-18" version="1">MTQQQHQQQTQQLHQQQQQQQQQQGGGQQQAGPQNGGGAGGPPANQNQAYPPMTLASTLHFLQSEHRRYARDRNEWEIERAEMRARIALLEGEKRGNEGALKSLARRCKMLEMALRGERSKFLTSSIAPGVGTGGLGTGHAAASSAAVSVGGGASPAMSGTASPVPGGALSLASALGTAGASIPPNKLVALQTLTASPVSTPGEAPKSIPMATSTSSPGQAAGHQNPPTSVSASGTGRSDSVSSGPGPTTAAANGFQSGTWASTAPSASGHSAAHAAGGLRDPRGKARSRDYLKQCLQEITYLTSSATLNPLAAHSYAAPGVPRPRKVLPDQVPATSAPGVLNLGGGAAATTSVAAASVAVAAPASSAATTTTEATEATPSSGSSHPGAEFEPVAASSIATATPVGFPPVSTSAASSSTGPDVFDSAPTPTPVSNGLLSSPGSSEVKPVEEGEPESEEQSSFVSTATEAADEDDDEVQANDSGASDPPSAFVPLKRQVSQPSGTSRGSNRSKKSVATDSTKANDADDAEDLDKAIAELSLPSERDAQSQPEVKPAETVEAVAASAIEQEGSATKDAPDAPEEVEASDAKEEVPSVAPEVSEAQEDKAADSAETVAPKKEENGIKPSSPSKSSAAKGTKQSATSGPSPVDEDAEQELPASLADSKTAATQDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8I2</accession>
    <name>A0A2S5B8I2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8I2"/>
    <dbReference type="STRING" id="741276.A0A2S5B8I2"/>
    <dbReference type="OrthoDB" id="2536221at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1096" mass="118436" checksum="C807CCDDC4EB9647" modified="2018-07-18" version="1">MAPRSLSASRGTTSPRNRSPSPRSRTPPRGDPRCPACCHACRAAAAAAAAPSHGRAPSGSMANRASPAEIAAAAHQDLLASHRDDAAAAAAAEATTINAGLASLPPPPPPPAGLQGHYQGGGMNGLEAAAGALTLDSTQALQPSLPLLVPGQPGYGQQQQQQALQPATAVSPRRSRHRHRHHHHHHHHNGTKPKRPPPAPPADGSAGPPAPVKPVLPPDGSVKTCEAVDRYDELCEEVVVGGWKGKVPRRWCQIHEDEEKHVRSSFWNAVSSLPRLSRTHPLPAPAEITTSTSFTELEAWETVARQHIELAKRAYDAWVFHREHFFAAGGDLVDRLEGRGEGPDGTDLARGAWEEVRLRGEKAEAVLKLIIRRSHFLVCDAEDALWLLHPQRCERNDGCGGGGAAVGDDSTSSHSSCACSHDHSWCGDGSDCGCSDIDDDASSCCSACHAGDDDADSVRSADSHAQQQQQAHRSTHNPAHPHHQHAPPEKAPHNPLRPPGSPTLAPEAEEPDPLLALETLRRTELLELLSLTGSHASFIREGRKSVERVRIVECLFRRLISRDEELLVKAYRGGHDHVLRFFEDPALVTLPSLARLHRALQRTSPVELKEAIMDAFRAIAWEESGATETEDGEEGVGMQVLGGWVYKNQLERSMTPREWSHLYDLCACPGCATRCCMRFDDLALIRRLTVVPHGPHPPPFELWASEYETEAQKVLKALDVVWCAGKQREDDPKPKRMRQPDGGETVWTQHEERNWAYLKISANHPHALAILSFLSKYFTMVLRSWREHAVWETLRFFPPPAKNLWTHRMRSAPTKAALLRSSSGTATPNQTNKATAWAALPNAFNVYERPLQILAGFESLDSPEKEQDMPRFFGTYELLILDAPSDSPYVAVDTYLARPLWAFENFLAATVALACGIKVPGATVFQDGGAASPDQIDMPALVQAALEHGAVESFLRGDLVWDFGDVKGVTTPFPAHSGKKFAGVDLKKVGKDGIVAPPLPSPAGHPPQQQHQNGGTAAVGHGKKGAGGKGVNGTAPANKGNNSAGPATPNGAAPANKANGGAPAAGTGAERQRKERVLDTLRDDKLARKLARSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8T1</accession>
    <name>A0A2S5B8T1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8T1"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39735" checksum="502D201DBD4E4AA9" modified="2018-07-18" version="1">MAPTPTADSLLASHQTPYTDRTLDAIRDLHLVFSQHDKAVEYTVFAQCRNARSLYIGCADRGTPTFAVAPLQQLLAALRRLERLEFAEHVRQLANLRLPTFLRYLSLPVEAVEGARLDYLFVWEIKLSFCLKCSGSAAVPPLPRLPWDTLKSVELVFERDPTQELVLLAGQTQGGVRALKLHAVRITHHCYELHLFIQPARLGLLELAHAALGGSRLRRLVIGSDEDQHLSLTGRWDSLLNLHLNLHLYLPTENLPSDLFAIIEACPNLLHLDLAHVAFSSGLTGTYAPDTWLAKPAHRLATGAPALFGLLYRLRHDTRVIRFQVWGPNVREAVRWSRRTAAEDFVGERYCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B909</accession>
    <name>A0A2S5B909_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B909"/>
    <dbReference type="STRING" id="741276.A0A2S5B909"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000024">
        <property type="entry name" value="Voltage-gated chloride channel, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="783"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="840" mass="90959" checksum="3A24DDA744C8DA79" modified="2018-07-18" version="1">MPPAHEASTSRHTLDDARIGRRNGDASESYMDEPDSPFLRQGAHSSSVTRHSATHSTLRPETPNAMSGSSIDWTLEFARARNEAAQIDAQPGLRGVSARLWHASEPWVVVVVTGVVTGAIASCLDILSAWLSDLRLGVCKDMWWMSRGLCCAGLDPKETCRAWQTWGEVVANERHIVARALAQYSVYIALAVLLAWTSSAFVNVFAPHAFHTGIPEIKVILGGYEMHGFLSPMTLVIKSLGLPLAVASGLSLGKEGPLVHVACCVGDAALRPFRALRGNGARQREILSAAAAAGVSVAFGAPLGGVLFALEEISTFFPGSTLWQSFVCAIVAAVTLQYIDPFNTGKLALFTVTASQVWRGFELIPWFLLGIAGGVWGVWFIRLNAEWERLRRSSGLRDWPVTEVTVLALFTAVVSYLIVFMRIPSAELVVNLFRDCSEPDPYGLCETSNATAVVLLLFIAAFAKTLLTAVTFGSSIPAGIFLPSLTIGACVGRAVGLVMDQIHRANPESWVFSDCPADGGCINPSVYAVIGAASALGGVTRMTISLVVILFELTGAIDIVLQLMMAVMVSKFTADYISRDGIYETWINLRRYPFLNNKVDYRRDEVLARHIMTAATELACVSDEGWSISRIEGLLLQEGFSGFPVVRTLKDRLILGYIGRFELQQGLARARQSEEATASTPCFFSTSVHSLDGSTTTSRGQTPARGRQIALPLDPSRAAATATMAWDSDAELGPSIQDRIAITEKQELGAEALPPGRPRARPPSAGAAPARDVPDWVSLVPWMDEIPVTLSEDTPMEVVVQMFQRLGLRFVLLARQGVLKGILTKMDLHVHIHGDEEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9B6</accession>
    <name>A0A2S5B9B6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9B6"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="769" mass="83340" checksum="5804D64D4170E70D" modified="2018-07-18" version="1">MSAFAVTLDELIASLNQAASRDDSLRADPARRHLDRATIRLERAYAALKLAGTRAPAQLLVRLRGRAQELEAALGEAEVQASTRTTLLARKVVDQIDHHLVKATASEERSPDHGTGHSRTPSADLPRRVPAQSAEVSGPSEQSAPARHPRAPSLGPGQGDDDAAAIVARRAKALSDCFFLHRLATGQVPANASLSTVLRAIFAARQSAEPAGSDPATLATDLEDRIRTQLRCAYFDSFRQAFDASDSDPDGPASIGTRSAQRQPAWNRLARDLIDATTGLIPSRLRPDRSLYPSSSDGSTMRAAVKQDLTSEQLPSDRAQFETACLGKMWRLARVLQRLCAPARDAQVRTLLDSLEPPAPTSGASAVSLVNLVERVLDLAEAMRGDLDRFKSAASEHMVDAMSEADLQEIIKQEAAELERATVTEWCGGEEGVRWSLRAWIRRDFLTPATSSSEARPVPSPEPTRVDFIGALVDSLFSTRSVALTDLGRLVTNPSELSRPAAEATAAEPVASTARDDNPLPPALVVLAPLLFELQNLLQALGILAAIATLLVSTVGPAEDPHGLDRLFQRLWTILEQNISRAPSHSAELRSDSEVDLASTFEYADSTRLANLADELVSYLSQPTNGRTPPQLATMERVRSGVDRILRYEDPVWKLLMRRLRDGAQAALLRAIAEEGLRPNGATTSARVPSVLRTGRMASSRPAPAANEYERPSPLISPIKGFDHPPFLAAKVEEVLQTKLLVGVYRHVEQVWGDVFRWPGSGEEAAMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9D9</accession>
    <name>A0A2S5B9D9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3726</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9D9"/>
    <dbReference type="STRING" id="741276.A0A2S5B9D9"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="333"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="503"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="785" mass="83947" checksum="914E667813B2F1B9" modified="2018-07-18" version="1">MSRGGYAEAYDPRVSGRVSLSQFDQSIASSLPADLLLALAGSKLAVAFTLHATREWLFARGYSPWTCTAAVLAAGGAFLSLWERSWEASRTPRRKQTRRPLLPLSLSFFLETLFALLCVDRIGATKFLLLASFSSLWARGFPLATLAGRKASDRSNAFILTTALIAAAYFLETLIAAWAFGGAIVRHAFGSSTSVTNSDEAVSWSTAILISTLTGAAWHVVDPLLTRSLLSHFPPIKIVRPGWPIAALVTFAAGRLAFAHAIGGTEVVLAVVGWKVVGHMVATDPRAPVVSAGSVTTGSTAPDASFVARCECFYRHARATIKVILDSPESRRIFLFLCINLAFMFVQMAYGVWTNSLGLISDSIHMFFDCLALGVGLFASVMATWPSNNVYTYGYTRMETLSGFANAVFLCLISIFIVFEAIQRLVDPPEISTNQLLTVSSVGLAVNLVGMAATGGHHGHSHGGGGGGGGSGHAHGHGHGHSQTPVRSNSTPFLTMSEQKDEMFSNGHANGHSHASHARSPSTPTHQRSRSYAASPILSPSPHAKHARSGSMAVLSTPQSAHDHTHTSNGLHSHESFTPEANACGHGHSHGHAHDHGDVIDRDEDEDDCEGEAGHGGHSHNMKGVFLHVLADTLGSVGVIISTLLIERYGWTGFDPLASIFIAVMIFASVVPLIADSGRILILDMGPEREEEVKKALVEVSRLEGVASFTKPRFWLLDSSTMVGSIAIQLAPASSAYDSHGQPSRHYASFEKTKARVRRTLKRHVAGLEHLSIQMEPTGGFASDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9E0</accession>
    <name>A0A2S5B9E0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9E0"/>
    <dbReference type="STRING" id="741276.A0A2S5B9E0"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22181" checksum="9DE0C0C79400E48F" modified="2018-07-18" version="1">MDPQELAAQEALDQGTEALQKGDFETAKQAYKRSVDIKQTSIGYYNLGVVQYQLRDLAGAISSFEASIQHTPAEVKPTFPNPDEPTPELTPAQAILADTHTNLGAAYILSQPPNAEKALEHLQKALMMNPDDGEVCYNLAAVLEATGQLDDALIAYERSIKLGIERAAVNVRNISAKILGKRREEEEKGGKTGGSVASQDVSPNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9F5</accession>
    <name>A0A2S5B9F5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9F5"/>
    <dbReference type="STRING" id="741276.A0A2S5B9F5"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="550"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="732"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="898" mass="95436" checksum="731723E2D9C0376A" modified="2018-07-18" version="1">MAAAAAPLGMPHLGATASTSSDRSSAGAAVVHKDSPTPAADLVKDSKSKTVAVMAPSSTVNTTRGIGNSGEEQLAHLHAKPVVLGGAEGVVGEAAGKQPEWIAKVRKVRTVAEEAALSEAARAKEEETVRGPKGDKGVPAIEFASGSSASSVTGMSSSSTLPVGNRSTGATSSLAGASTASLDGDADDDAGDEKLGPKWLRKVKEAAATVKEKATGSSSNDTPDGGSVGTDSPNVISPAATRTSTVSFAPEASNGAPRVITDRDGKPVPLNPGATVGHDAASDLDGAGRARSTSTSVKDKVLETHDVDPRTSDEDFRAMFKDMPDDEELIEVYRCALSRDVLIQGKVYISETFLSFRANILGWETTLQVPWTEIVSIEKRATAKIIPNAIEVRTLHATHDFASFINRDASYDLITTVWRHAHPEADAVLAGAASKSLMPERTTGEPVASSAVSTASAPVGRPRWVVPHDAHEAPKADDKSEISYEDEHGQKKRHRFRSGLRSLGIGRHRRSSASSADGPTAAEKVKADAQAAADAPPGVHPPTTYDGDEYDNEALDCVLPTTPLKAFKLFFVDKAFLTKFMTEKEGLKEVEIGPWKALDGTEATQDALAAAKEREITYVKPLNAPVGPKQTHCNIRDLQEHFDEEGYFSVKTSTVTPDVPSGNDFTTVTRSVFTWAAGGGCHVRVTTEVEWTKVNRFLRGVIERGAVDGQRTYHADLEELVRERIAANPDEYTIPGVSADANTEVKASDMASKDPKRKRSSRGKSGGDSGGLLDSLTDITSPVTILLILVVLLFITNLFTLRAMRHQARLARQAHLGQPSEIASAVSRVLENFNSMHLRHIDKRGPAGTAAPVTDLRALQQTVLSLEQTLAAASSEMQVAVERARAVVDRTAALRRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9Q5</accession>
    <name>A0A2S5B9Q5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9Q5"/>
    <dbReference type="STRING" id="741276.A0A2S5B9Q5"/>
    <dbReference type="OrthoDB" id="2527451at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000085">
        <property type="entry name" value="Zinc knuckle nucleic acid binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="165" mass="16835" checksum="9A477286622DB6CA" modified="2018-07-18" version="1">MQCNQEGHISRDCPNAAVPKKCYKCGDAGHLSRECPQNPQGGAGFQSGGFASGGGAAGGNGVCYNCGQPGHISRMCPQGRQAGGFQQQQGGFQQGGFGGGRTCYSCGGVGHLSRDCVNAQKCFNCGGQGHVSRECPQPAGQKSCYKCGELGHISRDCPSAEAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA23</accession>
    <name>A0A2S5BA23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA23"/>
    <dbReference type="OrthoDB" id="2527809at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="90" mass="9598" checksum="E56A85FADC3EC5D1" modified="2018-07-18" version="1">MSNSDKFQQDDAIVDAEPEVQGVLAGEGSDDVGTIGKDEFKNDEFDGVSEENIIEGERSNRASGFAEAEQKADDMVEQAVNANDGTSRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAF7</accession>
    <name>A0A2S5BAF7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAF7"/>
    <dbReference type="STRING" id="741276.A0A2S5BAF7"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="67"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="537" mass="58130" checksum="6BEA0517EC9F9123" modified="2018-07-18" version="1">MSSKPAQKRSRPSDQPGKQVRLSLSRCGHAVDSSRLVDSQAKRWKGAADATAEVDPQAQEQALKAYMHHALKLLHKAVKKSKTFEVQKLTRKVKQTKEPKDGKVDEKAVDDLDAQLSALKKLDLNSIPPHVLKTRIAKFGPLRSHLSLPSLLSAIPVPSSSKWVEYAPSSAESKARNRILANKAVGEAWDEISRAVRKRLGEEVEPAKGAKGKGKEEEKKKGITMDPGRQAAIEAAFLNGGSDEGEAQEDGGADGEEADEETSEDEGPAEGFSSGPEDEGDSDADEDEAIQRELAALGGSGSEGDWSGSEEDEDDEVEAVPPTTKRRKLSLSPPPPPASKKAKTAAPSKPITSSSFLPSLAAGYISYSDSDGEEARWIKDGERKEQQGEKRKNRRGQRARQAIWEKKFGSAAAHVVKANGGKPVPLAKVKQQKTQRAERQRANPSTKSTGPLSTSGSFAPSYDNDGPATAAAAPPRRDRHSFHEPQADPGWKKREEVKKQAEEAEKVHPSWEAKRKAAEALKQSAALKPQGKKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAS1</accession>
    <name>A0A2S5BAS1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAS1"/>
    <dbReference type="STRING" id="741276.A0A2S5BAS1"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015758013" evidence="5">
        <location>
            <begin position="21"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="681"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="548"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1038"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1143" mass="121802" checksum="45F5553E1DECD585" modified="2018-07-18" version="1">MRLSRLWWLALPLSAHVVQGQREPVQLTFGVTEGAQLRQPGQAGGQGRGDGGVPLASVENDDNEPNQQPLDVHFASGGPASPNHDHLYQLAVSLLDSLTAHSPPAPPTAYSPHLAPTLASSANAVSVALDKLQAKLNGTVTGAAFSRTRAVVGRVGQVASGFVSSVSSSRSPRGGAAARKSGGGSNTENLLRAVVAQIKAVLGTGATTPARGGSASQAGRGDQSTSAASSGSSWKDRIGAAAALKGEYVVLSDEEIAEGWREVVDLAQKAAEAGSVDALVLLGNLYLGGAAGLDADPSRAVEYYTHASERYGSGEAQYKLGFLYGSNYGSAFGGLEGQGQQGSALLHYTFSALSGYEPASMTVGYRHWAGIGTKQSCKDALPWYKAAADSAIRSFNSGPPGGRHLPPPKIRLSDHEGGPYGPGASSTRASMNTGGSTAQTRQEWDDLVEYHLFHAEHGDVAYMYRLARLYYQGFGGLGLGGARDQQRGRLRMVRADEASGVSPATVGGGAGHDGLWNGGRDFHRASKWFVRVARRLWPVDPKEATWDPAWGPIPGSPGSGATAAARAKQGARSGNGNKATPATPRIGYFDPSKDRKNDKLDPHSAMVAGLAAGYLGRMYMRGEGVPVTYAKAHLWFSRGQKQGDRESNNGLGIMYRDGLGVARDLKKANMLFHAAAQQDLPEAQVNLGKFHFGMGDFALANTYFEHAIRSDNTRTPDTFQAYYYLAELAARASTDSCPTAVSFYKRVAERGDWDHEVWWEAERARERGDLRTALLGYWMMAERGYEVAQNNVAWILDSNKQSLRLPLFDIAAPLPSAAAKQLDRLALTYWTRSAAQDNVDALVKMGDYYYSGLGTEDGLPQLEKAAGCYQSAATTRFSAMAMWNLGWMHEVGKGVPQDFHLAKRNYDMALETSGDAFFPSSLALVGLYGRALWHAITKSGDDELKALSLFGRDPDLDGIGAGFAEHGLWNFGRAWRDIQRSWGVDPGPDPEVLPAHEAEQAEGAPADGAAQGAAHRERADVRAAQRALEGAEDPMEWEGYRGRGRGGEGDEEEMEDDGDFGGTVAIVALSMLLAWLLYFRQRPEQRRQAHPVPAPAPAPAATPHPPPPPAAPTASPAPQPPTEETSGGSSSADPAEGGDERQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAU9</accession>
    <name>A0A2S5BAU9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAU9"/>
    <dbReference type="STRING" id="741276.A0A2S5BAU9"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="214" mass="22882" checksum="E272746FD578A7FD" modified="2018-07-18" version="1">MKSCNRDDRQQLQPDQLRLASILSFCFSLLLATCDTDTPLRRLVVATTWVYLLVSGNPMGLFNKSSTPVESAPPPASNHSTSLLGCHKSTSSRPSTETERHGVFSRNRSSLDESRSGHRAAATVVGGDGGGGRGLHLFSRNDSLTAAKTKLKTAQGAEAAADAALARASHAVKDARAEIVRLEKEAEAEAKAAHEKQKAAKSVRREGNKLGRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBI5</accession>
    <name>A0A2S5BBI5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBI5"/>
    <dbReference type="STRING" id="741276.A0A2S5BBI5"/>
    <dbReference type="OrthoDB" id="5593278at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="23143" checksum="A5EB5495A1D8E4C5" modified="2018-07-18" version="1">MASLIDDANLDLASTPGLPPVAAIAEAQQPSAPPPSAIPTAQRARTVNGVHTEVLVQVYADRILVIVTQLGRIGCMIQVSPPPPSLPAPPPPAPLTAPANGASSTHAILASLPPPHPSTVLSPLFGVPPDAHLASLHDLYAAQIGAIVFRRFGHGAEGGGLGPPGGRETRPVVLGIGIKPASTRATAAGALSGSTDEHDDEDGGGFGLSERDKETFAQVMDMVSECLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBX4</accession>
    <name>A0A2S5BBX4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBX4"/>
    <dbReference type="STRING" id="741276.A0A2S5BBX4"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="6">
        <location>
            <begin position="35"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="7">
        <location>
            <begin position="159"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="7">
        <location>
            <begin position="354"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="407" mass="43970" checksum="8E030EA23962E693" modified="2018-07-18" version="1">MTPLGRPLSRDASHARHALCQAHSFVHSDCQTDNEAKLEQAELLKKVLDAVKELVTDANFDCSDEGIKLQAMDNSHVALVSLNLAKSGFTDYRCDRDMSLGMSLASLQKIVKCAGNNDMVTLRADESLDVLALLFEAKKHDRIGEYEMKLMDIDAEHLGIPDTVYDAEIDLSSAEFARIIRDLKELGESVKIEVSKEGVRFSADGDIGSASVTLKPSDRRARDASAEASGSEDEEGEDEENDEEEEEEAADSDAEPKDEDEDVEVEDVKPEINGSDAGSDDEDGPAKKKRKTNAVEDSEDEGEASSPSASSPKKAVQKEKKPVVKKERAAPVKKEKKPVKKASSASKTKGKGKAAAAAKGGKKKADGDEADAGVRINLQQAVALTFSIKYLSNFAKSTPLAERIADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBY6</accession>
    <name>A0A2S5BBY6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBY6"/>
    <dbReference type="STRING" id="741276.A0A2S5BBY6"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="434"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="492"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="620" mass="66992" checksum="CE19BDE4323F7AFA" modified="2018-07-18" version="1">MPNAKRSGAQRRAQAKARASTGNGSTSGIHAGNFTPQGNFAFNFQSPHASTAPTASGSGTGPSTKRTRNGFAAPASGESTSSDDDDDDDDYSSDENGRDGTDDSGDDDHVMSEEKPDADLTEPERVARANEKKELGNVAYKRADYPTATRFYTHAHSLDPTNPALLLNRAAARMGSKLFSAALEDCLAAHALQLNDPQVKTLVRTAKCQLAVGLVYPALQSLHEAFRLDPANRATAQEKARAERVAAHVDNIQRARERKDWSMVILGVDAAARDAEASVTPKEWRVWKLEALIGKKRFDDAASLAADLLRSDPKQPEPLYYRGLCLYLSGQNDQAIKHCQEALRNDPDYSQARTLMKRIRALESLKEAGNEAFKAGRIPEAIAKYTEAIAADDENETMRATLLSNRAAAHMKAKSYESAIADCSACLELDSNYFKAYRTRARAHLGLEDFEASLRDFKQAYEFAPAGSNDEAALKREVREAEAALKKSKMKDHYKVLGITSTATEVEIKKAYRKMSLVHHPDKGGDEAVFKEIGESYAILSDPQRRARFDAGIDENDPHGGMSDYDGFGGSPFGGGFPMEDLFGGGMGGGFGGGFGGGGFGGHSHGGFGGQSRGFSSYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC10</accession>
    <name>A0A2S5BC10_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC10"/>
    <dbReference type="STRING" id="741276.A0A2S5BC10"/>
    <dbReference type="OrthoDB" id="2529223at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015608507" description="Protein CPL1-like domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="3">
        <location>
            <begin position="807"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="864" mass="84817" checksum="D6F9357DFB7DD809" modified="2018-07-18" version="1">MMRFTLMSAAAISAVSASVSTSVFPNSLCQGASDSLGGLVGVGKVTLANGEVEVHCGCPSDNLADFEACPSSQKGESVCNSVYDMASGRFSAACDVVECSGADCLDTIVNEVVTSADECFDSERGSLGVSTVDGDSQCACSSDVDAAGFTACEAPAHGKATCSTLDPDFLGTTSEHPVQVSCGVVCDEGYTLTLDGTCTKIAKRDYNAINMGPGPVVRYGSSAAGPSKSMGMGAGPSQSTSMGGMPSSSAGMGGNGGMASSSGMGGMGGNGGMASAASSGWYNNMGSMGSSKGNAMPTTTSVHPHQAHTTAGAGGSMATASASSYSYKYHNGHKSQGHGAGYQSSGIWAGAKSSAGVSSGSSSSMMGGNNGGSSSSMMMGGNNGGNMMTTSSGANHNAKPTTTMMGGNNGGNVPTTTSYSYKYHNGKSSMGGNNGGASTTMASRLPYWSQVSMVKAAKASNSAIHWAHKRDAVPTAAPAYVYKQHDARAAANLHRRASSAAAGMNMGASSMKMGGGAGSASSSMKMAGGSSMPMMPMVTPTTSAGANHAARPTSGAMMGGSSSSTGSASMATASASSSFKYGASSAGNGGKGMGSSSYSGPKASNSQGWYQSMPSSVPSGSNHNARPVPSSSGSASSSSMMGGNNGGKTSGSVTSSTYAPGPSASRGSSASRGPSASQGWYAPAPSSGPSGSNHNSNPSGSNSGSGSGSSNGNNGSNGSGSNNGSGSNNGTGSSKTPGSGSSTSMMMNGGGAVPTSQPMKYAGSSTATRGAAATPGPSQRVRRASNEYVFSDVCAQDERTCPGDVMCVRLDDVTECGGCHATGDAVNCLEIPGASSVSCLRGGCVVRSCQTGYFQTAEGRCERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCK4</accession>
    <name>A0A2S5BCK4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCK4"/>
    <dbReference type="STRING" id="741276.A0A2S5BCK4"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="411"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="770" mass="85842" checksum="C8BACD6180955B85" modified="2018-07-18" version="1">MSGDRGKSLPIPPPSPAFASTSGWTPAAASRPEHSAVAIPLESTTPLVPPPETPQVHGGTGFDKEYSAYEGDAAGREGDALLRRSDEYDDDERRKGHRAVSPLDTLVRLLLGMFTILGFLVFLARMSVLPEHQTARVAAYMPSPVRGLIQVAEGPVEPHPIIPLLREAKEKWHKMTTSQSRTFDRATRNYKARYGRAPPPGFDKWFAFATQGRNHSLVDEYDQLMADLEPFRALPASELRRRTAELSKVPGISIVSIRNGEAQVHARSSSWAPADAFQRMLAAFVRDLPDMDIAINERPEGRVLPRQQRHVYMSDYGLEGDELVANMSDSFNRPTLPHFRPEWKHDGSVWEAYRRSCPTDSAARRLVESIRSVESNSGLVVQGRASLSGQAPKSRRVKAKTIQPVTREMTFSHDLDAVFNMCDYPSLHTLHSAFYSDQRTIEHLFPVFSPSKPSGYADILIPSHHYWSPSSEFTYELEYRRGQTRMPTDLEWSLKRDSSYWRGKVTRGADTPPGHGSSFQKQRLVKMANEANHEEQRVLVSLDADTSSMTALSVSSLVANKAMTDIAMACEPSLGECSYLRSLGYRVEPPAALSESWKHKFVLDVDEVGFSPRFPALMESKSAVVKSSIQREFWHGWAVPWCVWLARDAVVPKHFIPLSSSYSELYNIQSFFAGYSSSFVSHHGVNASHNEPTVISQAAGKADLPTNADGTPFENDKALEDIAQAGSEWRRDHLRKEDMECYVFRLLIEWANLLAGDGSADGATVVAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCQ2</accession>
    <name>A0A2S5BCQ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCQ2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCQ2"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="499"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="832" mass="89747" checksum="5E4DCB99280A7431" modified="2018-07-18" version="1">MASMLRLGSRTSVTPPTSPRRCRVYGTKSLVHPTTPGLAATPAAPMNRSPSHWAPGDPIRFASDRAPSARPSVSSTSPKTTTNASGPDRAGADRGREWQPGQPIRFGSQPSKVRNAMPDREAGMSPVKKQSRLSEASVNAELGARRSPGTPASSLSWVPRTWAATKRPSSAPAPSPPPYSGSSDPSSIETIRATSSVGPSRISKAELDLLVDGIDFDDDFADFMETEVSPQPKPSAAPSTLPRRKVLTDDELEALVSGIDFSEDLETDEAPDAAAVPSPPRHCPSTALNNGAGLEKSSTAPSPSPRSETPDENDDSRTSSLLDLMNSPTAIRTGDESASLSPTPRSRSRSRSAVVEVIDLDSSYEDLDEPDQFTRSAVVATPATLDLADSSDGEVEIVSRGRRPAADPVGGKNDAPPLPSPAVPGFFARPEGLAPPGSASTSVATKIATNVKSSAVAATPREAARLKKTAKAGEDAQRQADFRRRWPRTFSYKKWHKDVRVVYTANEIVVERELRAMSGPLGFDLEWDSYSGYRTQGKTALAQVSDENTVLLVHVAKMKRFPPALQGLVEDPHRIKLGVQIAGDGNKLKRDFGFEPRGLLDLNACVHHYDPSRYHGRQRRGLIGLQEMTGIYLDHFLPKEHAVRTSRWSAVLGQEQKDYAANDVYATVQIVRQIQALADVPSERAETDLAALSRRAFSPWTGFGPSTGARPTAARSTKAAATTAAVTHDDKSTAPTSPDQILSPRRFQAFSLFHRQELSLADVTARMSETKTVKPVTVVWNLLSAFAALEEHRIDIAWDVDRLVAAMDDIGDWPERMVAEHGKLAAKLRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCU9</accession>
    <name>A0A2S5BCU9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminomethyltransferase folate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCU9"/>
    <dbReference type="STRING" id="741276.A0A2S5BCU9"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="47523" checksum="A6E2CB76DB04607A" modified="2018-07-18" version="1">MQSSLRSLRASDRCSCLFKPRHFSSSPATCAPPFVYTTLPSRALLFIQGTDAPGFLQGLVSNDVRRLAARGDEDNPEKQRLVYANILKADGRYMHDIMLHRPSSTDSDPANSFLIDHDAAATSSLRAYLKRHKLRSKLKIGAGPEQDLVVAAAWRNPLDTGEGQSSEREVEAAEEWLEERKKAWDPRVNGMGRRWVEERDGEKPPAELFAPVTPDHFHLHRLVHAVPEGPADFPALPLEANIDFMNGVDYRKGCYVGQELTARTHHKGIVRKRGMVFRLFREGEDIPMDPLPSQALTPYPSLFPLPPPGSSLTLLRAGTSRRPRASGKLGSSLALISPSGNLQTLALAYGSVRTDHLGEGTDEFDGVFTVKADISDEAVVQGSATPGVDGAGGRPVEAGDGAGESEEEGGRWLAKAFMPAWLEFKLEEEAIAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCZ4</accession>
    <name>A0A2S5BCZ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCZ4"/>
    <dbReference type="STRING" id="741276.A0A2S5BCZ4"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="146"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="205" mass="21564" checksum="0C94B82DAA16D96D" modified="2018-07-18" version="1">MPDTPERFATQISDAQELNHISVFLTGQSPFPEGYGCTIHLETPGKGWQIIGGLTNAKPSAIFRLRKTFLPSSTSFSAATFGAPAGAPSASSTATLGILCEPLPSVEAQLAALGQSASAIAANPSNSTALVPASSAAANKRSNPDPVQLAQLVGKNLFNAVAGFAQPLPNGQPGQWIPFDTIEKWYREFERKLRTTGVGFLLHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD10</accession>
    <name>A0A2S5BD10_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD10"/>
    <dbReference type="STRING" id="741276.A0A2S5BD10"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="80867" checksum="BD68E1BF362F618A" modified="2018-07-18" version="1">MVTARLRSAMRPWPALSSSTRTYSTSASSRAVFPLALASDARDDPQLQPPAWDDLIPHKLTNGAAISQQSHSGESSKKRRTAWLDPKPSSLHNTGPRTHTNRGWAQKRTSSDQQRAGLPPANDPNNISPFLPLVTRERNHLLAQLRQALHSRRPARTRMKSRRGTRPGDPSSPWDPDQVWAALARVLKYPEDVPTLPHSQFPSSTRTPAVLSADPSAHSLRDAGFFTSSRTADEEHALPEGDDFGRTKIPLSLPELRRAFTVFASSTPRTRNGLNRLLVVAELIAQKRGGDRPRAMLSPYHRDADGMEGDSHRLQGGGAGLRDKDWAALVSFVGANLRTARADPEVKSALALFSQRLEGRPPSSQAARARANPLSPSRARPTDERMLYNSLLHVVGRAKMWELFEQILQRMHDDAGLEPDAATFVELIKRDEQRGAPVSSAWAVFERGLARSTRGGQDETGAGALWNAIVSALGRRGMLPQAVELYEAMKAGKEVDVTQFRPVRDSSLDSPVALMATPPPPDDRAFTSLIQAHAYRGELARAIRILHDVLGPSGTRPAVHHFTSIFRAFVQHGQGRRGTAGFDRATLGGAHIRSHALRRDASALSALVSPSLRSPAPRKSEPEANPFTLAALSTLFESFLALAPPPRTIRADLPFLGARTAPSPKDMFWILFAFDRLSGGDSRIVLEVWTACERKFAKNGSGWTGWRMDKRVARMVETHRAVVVEHERRLRELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDJ2</accession>
    <name>A0A2S5BDJ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Responds to activation by environmental stress by phosphorylating downstream targets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDJ2"/>
    <dbReference type="STRING" id="741276.A0A2S5BDJ2"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="109"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="452" mass="50625" checksum="383B095B6D335D73" modified="2018-07-18" version="1">MATVGTQPPHQHPYARPAPERYAGIPSQSSSSNPPVGTLPASQAPAEFHSHGGTSGEVQAGQYSHPGGQDRPGIAPQPQQSTNVGPAPPPAAEKQKEPRRIRFSVGNKYTVQEVIGEGAYGVVCSALHKPSGHRVAIKKIAPFDHSMFALRTLRELKLLRFFAENQVSENLITVVDLIKPSSYDAFQEVYLIQELMETDLHRVIRTQTLSDDHVQYFVYQTLRALKALHSVNIIHRDLKPSNLLLNANCDLKVCDFGLARSVATAEPAAGSETGFMTEYVATRWYRAPEIMLTFRQYTKAVDVWSVGCICAEMLSGRPIFPGRDYHHQLTLILSVTGTPTADEFYRITSRRSRDYLRALPLQQPRDFAMLYPDASPEAVDFLRRTLAFDPLKRITVEEALEHPYMANYHDPTDEPVAPPLEPGFFDFDLEKPDREGLRKLLFEEVMAFRTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDM9</accession>
    <name>A0A2S5BDM9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">BMF94_2159</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDM9"/>
    <dbReference type="STRING" id="741276.A0A2S5BDM9"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="155"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="358" mass="38864" checksum="E506307650761A5D" modified="2018-07-18" version="1">MGEMNRRVKAAYVRSGCAGDVSAIVMNGAVGAVRTADKSVCDGIATGMAPPRGRGKGRPAGSLGRGGRTNTPRVQRDRSHYAGPGFSEIPASAVDQGKSGSSDEDGSEEDDELTNKVPVAMWDFDHCDPRKCSGKKLARHDLMQELRVGQRFQGIVMSPKGTQVVCPSDREIVEQAGVAVVECSWARLDEIPFNKIRSPHERILPYLVAANPVNYGKPYKLTCAEAIAAALYITGYDAHADLLMSKFSWGHSFMKVNGAIIERYKTCSTPESVLEMQNVMMQELEAEQAENKRARDELHDGGDMLISNPNHRGADWPSSGSEDASDDGEEADSAEDEEDDADYEVDKLGNRIAKAKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDT0</accession>
    <name>A0A2S5BDT0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase-modifying factor enzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDT0"/>
    <dbReference type="STRING" id="741276.A0A2S5BDT0"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="94"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="206"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="364"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="787"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="929"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110598" checksum="4D3833FE0D33D9D7" modified="2018-07-18" version="1">MPNAASTAAMVQPPPYILDLRNRSPPASPEQSAIDPARSSSPSSLGDSEDAASTHATSEAPSDPLRDQIIAGLIGSSKPVVPGQTEADEKFAYKRTIPTMTLYSERGLSIYEDITKTKAYYPFEAEKEILEKYGDEIACRMFGLPSSLLVPDVLLEKQQAHFEQSPASNLAAKKEKWGDATVGLHNYGVNGSANLSKAGVLPTQGLAVELGSGSLDKTRHLLRSMAKLLQNGTGDDDASPLQSIDYKALDLEAASLYSTLSSLASVEGDCVTTSLEQQAQPGSKRRVSVSGLHATYDEGLAFLKSQKDVGSPSSVFSDLPDLPTSPKSLPTSLTSVFEDEENLPPSLAAAQQSSASSPADGETGRRATSIMWLGSSCGNYTREEAVQFLRNIDLREGDTMLIGIDGCADGPRIETAYNDPEGVTAAFILEGVDVAGRTLGGDAADALNQRNFDYVNRWNAELGRHEAYVRANKNVAIPISGAEDVKEVTISEGELLNIEFSYKYTFAEAVALFHLAGFRLIQHWTDSSRSHYLYLVEKPRMWFPATQESAAKMLGIEVAENEQENDYGVPLLEKWEEMWRAWDGLMLGLIPRSLHFTKPIPLRHIPLFYVGHIPAFRDIHLSRYFNEPLTEPARFADIFERGIDPCVDAPEKITHWHSEVPKEDSCWPSIEEITEYEAKVRDRVRKVYVENEGKWTTKLARALMMTFEHEMMHWETSIYICLQAAGSLNLPPGTAIPDFASLARQVERDASVTGQQALLEFPSQTITVGHDDDDTRDDETTFDPARQYGWDVEHPQRQIEVGAFKLEALPVTNGDYFDWLGRTYQQSDSALLPASWSQEGGQLTIKTLFGLVPIEFAREWPLAASGEQLERFAKDKGGRLPTFGELSAFQQQNPVSTPLANVGFVNLHPVAAFIPGKARDGSQLPITDGGLWQWTSTTLEPWKGYSGSKLYPGYSSDFFDGKHQIVLGSSFASPRRLARPTFLNWYQKNYPFMLGGARVAYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDU5</accession>
    <name>A0A2S5BDU5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3 11">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_1916</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3 11"/>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDU5"/>
    <dbReference type="STRING" id="741276.A0A2S5BDU5"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000010">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="770"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="794"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY74940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="857" mass="95186" checksum="27F9E42992D03ACA" modified="2018-07-18" version="1">MNHVEPIEITKRVINGVYNGVTTVELDNLAAETAAYMTTRHPDYAVLAARIAISNLHKETKKTFSHVVADLYNYVNPKNGRPSSMISKETYDVIMANSDRLNSAVIYDRDFSYNYFGFKTLERSYLLRIDGKVAERPQHMIMRVAVGIHGSDIDRAVETYNLMSERYFTHASPTLFNAGTPHPQLSSCFLVTMQDDSIEGIYDTLKTCALISKTAGGIGLSIHNIRATGSYIAGTNGYSNGIVPMLRVFNNTARYVDQGGNKRPGAFAIYLEPWHADIFDFLDLRKNHGKEEVRARDLFFALWIPDLFMERVEQNAEWPLFCPAEAPGLHEVYGDEFRALFEKYEKEGRAKRTMSAQKLWYAILEAQVETGNPFMLYKDAANEKSNQKNLGTIKSSNLCTEIIEYSAPDDAVCNLASIALPSFIKNGEYDFQKLHDVVKVVAYNLNRIIDVNYYPVKEAERSNMRHRPIGIGVQGLADAFMALRLPFDSPEARQLNLQIFETIYHAAIESSCDMARDYAAAHPGESGSYPSYLEKNGSPASHGLLQYDLWNVTPTDLWDWATLKEKIARHGLRNSLVTAPMPTASTSQILGFNEAFEPYTSNIYTRRVLAGEFQVVNPWLLRDLVDHGLWDDAMKNTIIAHNGSIQNVAGIPDELKRIYKTVWEISQKVIIDLSADRGAFIDQSQSLNIHLSSPTMAQLTSMHFYGWKKGLKTGMYYLRTRAAVGAIKFTVDAATLNTAKTANAKAAAVTAASKPSPIRDITNGLARTTISPATAKKSPVSPPTPVVPSPAPAPLAASSTVSSTAAPIPAVDSAPSTEGEEEISYEEAVRRREQRELEEAKLLCSLENKEACVMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE09</accession>
    <name>A0A2S5BE09_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE09"/>
    <dbReference type="STRING" id="741276.A0A2S5BE09"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="422" mass="45646" checksum="2D2F825428E859D1" modified="2018-07-18" version="1">MGRAMRHFAITNSPVVRSFIKPVQAIVPGTTTSSQDKTSKSKNPYIADEEDDATGYEEPEEVLREPQQPEGAFLIPTQPVVDVLAAQVAPTAGTSDVKGKKRARDDGCDTADGDSVPYDAEKGTRYGVQVRYTEDNLPAKLEKYWAQRYRLFSLFDEGCQMDREGWYSVTPENIAAQIAERCRSGVILDAFCGVGGNAIQFAFTCERVIALDTSPVRLACAAHNAALYGVADRITFLLADWVTWTESYLARLELGQVPAEEKVEVVFLSPPWGGIEYQTLGEKKDDSNGALAAATAAGGEQPPSRKRARLSGATALTAVAAAAAIETPTEETPPSLLASNQPISSYPLAALAPLHGADLFRLAQRITPNVAYYLPRNSDLLEIAALADPVKGERVEVEEEWMSGKLKAITAYFGELVAPVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BED3</accession>
    <name>A0A2S5BED3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin-14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BED3"/>
    <dbReference type="STRING" id="741276.A0A2S5BED3"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="34626" checksum="9E1D847F892BDB6E" modified="2018-07-18" version="1">MGDDQSPTAVTDAAAQSVQLPAASASDSAPPPTPQPTPVPPRTYPQVPVYIAPPPAYAPNSTVPNFLRLVAAALLVGGTLSSAVAWIYKTILYPRLVIALQARTRLFRSHEAIYTKQHASVLGLVQAVGVKRLGGADAVAFRKRERERAAEAGTEAGTASSLAGEEQLNGKEEKREDEKQPLLEFGATTEGGAEDTSPSPLPPPPRILEPVKTSLSSLRSSLVSASPSANPTTLANPSNLVQPQGMLMRSLVTLNEYLESESYAASTFHTYRPYGAYGASAGSSATASGERKALQEVTHSFKAEIRSIKGALLNRRNFTRPEAAATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEK9</accession>
    <name>A0A2S5BEK9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEK9"/>
    <dbReference type="OrthoDB" id="2536450at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015571733" description="DUF7729 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="67"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="268" mass="27398" checksum="D722E9175B1EC227" modified="2018-07-18" version="1">MYSTTLLALTATVLAAAPAARAQLSGGDLLSGISSTCTGSVTYLVQSDFGTCANLFGALPVLTASGSLNSWLDTVCQQDACPPALIENATNIVEQGCKSEIEDGNALVASLVPIVTNFNSIKEGLCLRWRDNGTLCVTSQLEDLQSVLGSDLTLSALTNFNAADLASYPREQACDDCSHALTTKFQPLIAQNNTLFSGIGQTIQNFCGDTFLDGQVPPTVLTQNATGSTNGTAGGEEATATPASGAATTRSVGFGSAMVAILVASALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEX1</accession>
    <name>A0A2S5BEX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEX1"/>
    <dbReference type="STRING" id="741276.A0A2S5BEX1"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="491" mass="51821" checksum="1ADCFB972AF81253" modified="2018-07-18" version="1">MASSSSSSGGSGPNIDIFVTSILSNPAIRGRHERTRRALLSARVPYREHDVAGDEEAKKLWKRKNGGKNELPFVLVDGEPVGSIEDMDEAVEFGELRQFLRLDEPRPSPFSAPTTMRAPSYTTPAASSSATPPKPSSDDRSHRIDAALSKPKPSLDDFADLNLTEAELASLAAELTASSPEETYSSLLSASQSRPSTSATSAGSASTSAGSVFGGYGFSHSQQFTPSYGSTQPLKLEKVNFVRPIERRLADRNDERDVLDGIETDSLDEDALERLARELELEDEADARKRGGHADVGVAAGRGSGSAPPAIPVKTVESSIAPPLADVTAVEGDGGASLSRPLKEVEALTVPDVEKAANTSTRSGQALGAVAGERLATERVQLQVEPESDFERRAHAEAAQAVASAHQAGAADARADPHQLANEAASSTRTTGASAQVRQVKQVPDQRAQSEMPTFGVEAAQSPVGGTVPDVAEEQRAQDRRVAEAIRDGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF96</accession>
    <name>A0A2S5BF96_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF96"/>
    <dbReference type="OrthoDB" id="2538281at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="265" mass="28700" checksum="C7B30BE5DA6B17F2" modified="2018-07-18" version="1">MAGPPPPVSPRPVAAESSREVQAPRPHRPPVGPPAYPPTALLGPLIADGKAAQSGVLVQGVKWQASGILEDAANMPGQVAYIERPLTIHLGGPTQCIDDKGRQRTEILSWPPSAPGETWSYTWKFHLHPDLPTSSKFFHLMQLFSREQKGWVVALGLVQNKVRISSQLPPLLGGSDGTTPVPLPEIGADRYWGRTTRHYMLVTYGPNGAVDYSISDAVTNELLLRYCMQNVPVPAAGTIKTGLYRQHVCSPASAVVGDFDFRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFC0</accession>
    <name>A0A2S5BFC0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFC0"/>
    <dbReference type="STRING" id="741276.A0A2S5BFC0"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39359" checksum="FF46A51CCB9049F7" modified="2018-07-18" version="1">MAPVIVTMVRHGESKDNLSNFWAGHRDAPLSNHGNTQALRLGQAFADVPITAIYASDLNRANTTARRVWEVNKERNGGIEVPFTTSPLLREQFFGEAEGAPWDAGRYSSAHMPWEDHRAFQLSLALKIAPHAESLNDVARRADLVLRNFVVPHVLATANVPPDAKHPEQHHIMLFAHGIWLSEMMFSLKRAGDPQVRYVKSGGYQNTAWTRIELELDDPSAYHALGSEEKGANGSEPPADGEYPAPPAPSEATQPSRSNTTLTAEEADSIGMSPDIHALLPTLPSVPERNPTLPPAWPHANDLSHPTPKLRHRVVTFAQADHLNGLKRTGRGVGSAAHDEKQRGLKEFFSGGGTSPKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFG6</accession>
    <name>A0A2S5BFG6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFG6"/>
    <dbReference type="STRING" id="741276.A0A2S5BFG6"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="908"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="434"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="787"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1246" mass="136563" checksum="E24B1AE03E57C811" modified="2018-07-18" version="1">MDSLFLGTHKSRPVINLGATDRSPSSSSSSHADLVSRAKREREQRQLDRTRLAAVQKIQVSPLGRTRPRSPSPVPSPWTMSSGRQSAATSRIQFRVQFDALLTAATRQTTAADFVTATRLLVAGAYSQANPADIKRLALWCRVALQPPPALPSSAPSAKDVGQKQPPLLFAPFATTHGHRWAVLLRMTAALLLAEATRNVSLLQAPLFLEIVKIVADPASYPKYAVPLAVSLPTALLAYLLDAADLYPRLGGALASIPPQQRTHPCLSPLLTLSLLPLRTLASPDQLRQRAAACVAFSTSVLTVPSLFSPGRIAQPNLIAQFKAPSPFPLWDLVAALDGALSSSNNNEESVAQLDQAQTVALLANLVELVKGRLVPVPTNATAGGSGASGSKAATMTGSIENGKQLVAYLDVLRRLLGSLPLSALVVSDDLDQGEAQRADGQVETIVLDDDSSESEEEEDNDLEQETRGAGGSRQRRRQRDEDGDEVMTDSAEPARPTLKVDSRARSSIAYLWSREHLLALLSLSTRYSASTRPALCGYLVALLAPTTPPSPVRDSILNTLLYSPLSSGLLRELFRGYIRSSELGKALASAAKREKSAVVLAALRDERRFADEWPVLVLAIEMYARSLLTMGDDEFYAGAGAGAATSTTGRNALTLDEVVTLSAMVRNATFALYWQDEGGAANDGTRDAVMVDPVAQQTKRVTVAGMGGWAVEDVRAFMTRFLQQVHARDSRRQFTPEGHWHMTSAFDLRSFVETAVCVPRPFLLRFADVEPLTDALFTHSYEDERLEAEAEGEEAPPAPSAPARNSESHFVRRGLARNTNDDRGPARTSAISKRQLALISPRLGILRNIPFVVPFETRVAIFRQFVANDFRKLGLGDATSYMARSRHRAVVRRTHLAEDAYTHLNGLGPELKKRIEIVFIDEHGMEESGIDGGGLFKELLTSLSKEVFDTNRGLWLATSEQELYPNPHGYAKESNQLSWFKFIGRILGKALYQGILVNVKFADFFLAKWLGRQSYLDDLASLDPELYNGLLKLKTYPGNVEEDLSLNFTITEEDFGVSRSVDLIPGGSEIPVTNDNRMQYIVLVSNYRLNVQIAPQCRAFYSGLFEMINPRWLRMFNQSELAVLVGGTDEAIDIDDLRRNTVYSGWAAEENTPTVRHFWDAVATFSREERAKLVKFVTACERPPLLGFGQLNPLFAIRNAGSDESRLPTSSTCVNLLKLPAYENPRVLREKLLYAINSGAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFH4</accession>
    <name>A0A2S5BFH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFH4"/>
    <dbReference type="STRING" id="741276.A0A2S5BFH4"/>
    <dbReference type="OrthoDB" id="428346at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="572" mass="63570" checksum="E9A432A1E05EDAF7" modified="2018-07-18" version="1">MVAAHETVVNHYTDDDIALKEVGSDEPLLDPGRTDAWPGTPALLPSRLRRGKTSTGSPIVYTASAIVLVSLLVLASRVHTGVRSDWLPRWPFKLSRSWSPEEKALREYRWTAPPVDPTLVQKLDELSPAQNRVRNWLLEQRLETMGGIGVGLSATAPLDPRPPLASHAHPFEFAGEYEGPGVYINGSREKYGDLLYEWRFGRPVGVCEVGEWQLPYARMHADMLNGARAPRLLEYVCLAGHMCGGYADRMLGMTTALLFSIISGRAFLAHWGQPAPLDLIFDSPFIDWSRPYNVSSETSFAAGHALVTDRTTIHTLNQGSAGLDYMLPGLVDSLMANGSSRWAQLDANRGTVLRSFTYPSVRPHLDRLGLTPTNAYSCLINYAFRPKRAALAFIAQYTSYFALPENFVVGIQIRTGDKSMESAGWDRHTVAQYQYYFTCAEQLAMTYARPTQRVVYYLITDSNDLEQDAKRVLGNRVVVTGLEQAHAEIKANSSNVDDSIRRATDGFMRTIAESWIFAGTDYQILTANSGFGKIPTWQRGRDNTTVLNPRANCSLPSTLQTFVDMAQGWSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFS6</accession>
    <name>A0A2S5BFS6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFS6"/>
    <dbReference type="STRING" id="741276.A0A2S5BFS6"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45162" checksum="8309FBA83F31BAD8" modified="2018-07-18" version="1">MGDMPIRGQWQLRIYLRDGRVKISCHHGKLSPAALGKDVTIDLCLEVLCDGLLKEIATKARHEAAPDINPKSSKPYTGYSVSPDLDKIAQEQPWFASLAKERQTYRLTASVRRLDPFAKDVDSAACRRALLVVSSDSDLSPAGKDACLVFPRGASDGYRLWTTATFLQAASAYFQSMFASGCVEAVPARAKRPRLEALPPLVNPQELDRAGRDWDDSDDETDETDDSSASANPAHAIDDGQHDRGHCQITVRESAFTTYRAVLLYLKTGYIAFAPLRSSSRALHPKNGPHPRGDFLTNYTTKYPTLPAPASPKSVYRLADLLELADLRKIALAATISRLSPASIAYELFAPVSIAYEELRTALIEYAVKNLDAVQGTSSWKVQQEKAARGEIDGSSLVLTELLAAVVQARKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG61</accession>
    <name>A0A2S5BG61_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG61"/>
    <dbReference type="STRING" id="741276.A0A2S5BG61"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="68"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="173" mass="19258" checksum="7F5DE2A4DC1C5D61" modified="2018-07-18" version="1">MLAVRRARALFTQPTRTMSTTQALPKQDDANDKPWYAAFPAPLRSVAEGTLATMSAQELRQRLLDGPKEDDLLVVDVRRTDFETAFIKGAINLPAHSFYQTLPSLVPILSRYRSVIFHCQSSSGRGPRCAGWYQDALDKASLSAETSKAVVLTGGIKEWVKQYGDDEQITIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG79</accession>
    <name>A0A2S5BG79_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG79"/>
    <dbReference type="STRING" id="741276.A0A2S5BG79"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="350" mass="38333" checksum="2E215ABD5C3954C7" modified="2018-07-18" version="1">MRAWVIRKKGCPVQEALRLESDYPTPTASPGRVLIKVHAVAMNPVNWKLVETWGLNRMQKVPGVPESDVAGTVVDGDLQGTGLQVGDAVFGLVPAEHTAKTGQGCLAEYVTVDKHLLTKKPDNVSFEEAATFPLATFTAMNSLISTGGLRKGANQRVFINGGSGGVGVYAVQIARAYDAYVVTTCSSASRELVQSLGPDEILDYKERPLVEQLKAKFSGDNKFDIVFDAATGDADLYHQSPAYLKPKGMFVDVVGPQQHLKHGYVGLLRAFGDMLNRLVRPSFLGGTPRKYKLVMMKPTKPELEEMADLIRQEKLKPIVDEVFKFEEAVPKAYERQKSGRSKGKVVIKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGS9</accession>
    <name>A0A2S5BGS9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGS9"/>
    <dbReference type="STRING" id="741276.A0A2S5BGS9"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="399" mass="41696" checksum="A2FCEE2213D0297F" modified="2018-07-18" version="1">MPSGYFDSVAVPLHLPPSAYKPVIATGKGKGKESATPSSTYHVVEQWTEQERDDMVRKVAMASLLGYSTVLLTLSIPPTFDPSLLAFPTPLFPHLDPRTAPTGTEGLVMQMWRINVEAYGDEAVKGAGQKGYYGFSNSTAHTYPAQTTLLSVTPTTLASFSHIALSVSSPSPFAPTLITLDPSISPRLPFPLKRGLISSLSRAGVGFELILRGVTRLDSTGTGGADGANGPDQPGDAGKRRRNWIAGAREVVRATEGKGVVISSGAVKAGEMRGTEDLINLCSLIGMPPSVAKDALTVNPQRAVLRGLSLRQTYRGVISNPTVTAFTPASVASSVLSDPPAGGVPKKRAVADDEQARASAIADSTAGPSREGSAAVGARAGSVASSAPLQPKRKKKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGV8</accession>
    <name>A0A2S5BGV8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGV8"/>
    <dbReference type="STRING" id="741276.A0A2S5BGV8"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="819"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="765"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="849"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="95373" checksum="771793C2701D2EF9" modified="2018-07-18" version="1">MSTHDGWVKPFSFLRIDNFSMQTNEESHAFPLYYLLTHAHSDHLNGLNAKGFNGKLYMTAPTKQLVLDWMEAQERVRYAELGNRIKPSYKFANLEMRRRRPRGSGSAPSIAQQIVTIAYNQPFELEGPDGKPVRVVAIDANHCPGSCMYLIEGKVDGREHNVLVTGDIRIDADYLETLRRNPFLQPYMRYETPTERAASSSELFAPRERATSNGGDAATDARPRKRTRLAPKPLYRIWLDTSQVGLDEPLVPKEQAVADLIDLIGSFPDDTLFFLNAWTHGYEDMLKGIYRAYGEKIHVDWHKGKMYTSNAMRQSDPLLADLVHPDPMPSTLPHAAASHPPFVGRFHACERRWKCDEVWQHGVGCYCWEDEYQDHLQGVKKLRRPGSGERLPGQQEKLVVNVNPAEMPQWMWDEYLEEKKGQIARWKAQQAHGVPDGGKAVELPTSIVVPLARHSSLPELRSLVALFNPMTIYPLTCSHPKLYKMLPSIFGDLLAPGGKEQVQQEALKWAAAYAARQRQKLLEATLEEEDEHDGLIVPGLVADIAKKGLNVEGGEAAIKEYELWLRELQAQAATRSATPAQHAPQAGPSKRHRDDDADEDGPNAGSGDRISSDWVHVPRATEGDGGGSDAESAGGKEQNSGSSQQEPVEAANPEPDSLPAMRAGPPRMPSPFLHASQAEPPRLMSPFRMESSASPSIASGGRAGSLASISLSNSTAPRRRPSPELEVTPRTETSPSSAIGSPSSSSRMLAPVKAGPVQSPVASERTVSLPTKSPTASGSSSGAVLPPSSQIDRQQRKLYVEAFYRRFRGKIGVDGRIVPFEEGDPRLKGRRPLKTPSRPDPEQKEDQAVQLSPGSFRTVSATVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH32</accession>
    <name>A0A2S5BH32_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH32"/>
    <dbReference type="STRING" id="741276.A0A2S5BH32"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="2">
        <location>
            <begin position="181"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="543" mass="60475" checksum="126A7AC45ECA9EAB" modified="2018-07-18" version="1">MPAFPFAGHSSFPKMSHPHTRSPIRASKGDDTPQNKLDRASTTLCDRIKTALCSLCCSTRPTSRQQRRQERPLLASDSYSTRGDDAADGRTTARGDPSDKDEQRRRNQRGSDPVRLRSRPVLARPPIAGQDPTATRAQRKPSAQVDPGSWIASLPDHVQLDTLYLAGTHQSLARNYPLASSLCQTTSLTHQLENGIRALDLRFSLREEDGTLWAYHGPVPQRREMSEVFDEIYRFLETAEGRRETILVSLKQENAAHGFAEAVWNLIDSTRPTLWYDRNVWPTLDQVRGRCVMFCRFGFQSGRGLHPPIWPNDKRYLWKTEIGGRETVVQDWYGVRSPLSLPEKADLALSLFHPSSPAMLALEPLTSIDSHSASPSQDEPRPVPYRINFLSCGSFPTLYPSHAAKGFGAPKFGVGYRGVNALVASGLETRRRRVVEAKGLEISGSAVSEGDRDAPDCMTHDSDELSGGVAPLPPPATAEPEEEKPRPLRPQPVPPPMALPTRNVPTLDGQQRRDGHGGMLVFLDFWESPRKSRLVDQIIEMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHL8</accession>
    <name>A0A2S5BHL8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHL8"/>
    <dbReference type="STRING" id="741276.A0A2S5BHL8"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="2">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="246" mass="27340" checksum="1BF4191B3E2EC18B" modified="2018-07-18" version="1">MTDLLGDTVQQLVVESHRSQQTRSLLPYNTNHVRTVIRESHSLSQSITTTAAPFVGTQGAQPTQGVSAELTIAALALNRNKRGLYVYHQQRLDVLKDKFWEHGGVLSAAFGSETETRRNMTTTDEVFAKGYADLCLAFKTSTYGGFASRRRRDHDDEDSYLHDISDDEDEDDGFEVSLIEAVDLLGGGTNLSPPKELMIDVRVLRDVGQVELLSGNRINLKQGLQYHLAREDVESMIVSGDVEVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHW6</accession>
    <name>A0A2S5BHW6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_0558</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHW6"/>
    <dbReference type="STRING" id="741276.A0A2S5BHW6"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001148">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="102"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="291"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="744"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY76361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="772" mass="87576" checksum="056A3B321BD5332A" modified="2018-07-18" version="1">MNYEPASKRARTDHREHSTTTSDNPYLAHLHEPAQRMSGAAMNGKAPFDGWMTRKSSGKQVEQAMAGDTNPFTLRPHSKKYQDIFEVRKKLPVHQQMNEFLEMFNGPSQFIVLSGETGSGKTTQIPQYVAYADLPHLRKPGLQVACTQPRRVAAMSVAKRVADEMDVSLGEEVGYSIRFEDCTSPKTFLKYMTDGMLLREAMNDHMLSRYSTVILDEAHERTLATDILMGLLKDIAKRRPDLKVVVMSATLDAAKFQNYFFQAPLLKVPGRTFAVEIFYTPEPEPDYLEAAIRTVLMIHQAEPEGDILVFLTGEEEIEDACRKITVEADQLPHQFGPLKAVPLYSSLPPQQQQRIFDKAPPPRTPDGPPGRKVVISTNIAETSLTIDGIVYVVDPGFSKQKIYNPRIRVESLLVSPISKASANQRAGRAGRTRPGKCFRLYTESDFVKELEEQTYPEILRCNLASVILELKKLGVDDLVHFDYMDPPAPETVMRALELLNYLAAFDDDGNLTPLGDLMSTFPLEPQLAKMLIVSPEFKCSNEILSIAAMLSVPNPYLRPNSQRKEADEAKAQFAHPSGDHLSLLNLYHAYKTNPDQNWCWNNYVSFRAMQQADNVRNQLKRTMEKLDLDLISTSFEDKSYYENIQRALTCGFFMQVAHREGEKNGYLTIKDLQVVGLHPSTGLDHNPEWVIYNEFVLTTRNFVRTVTETRPEWLYEYGSMYFDYTNTKAFPDCEARRVFERIATGKSRSSGSSKRGGADGDKRDKKKRKDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIL3</accession>
    <name>A0A2S5BIL3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0172</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIL3"/>
    <dbReference type="STRING" id="741276.A0A2S5BIL3"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="110"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="353"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY76583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="919" mass="101179" checksum="44F7C8E9DA6CA692" modified="2018-07-18" version="1">MPSLPAADEWVVAQGSCTNGEQAEPATSPSATPTKRASRASKISNDVDYTAFARTTEAATIEFRVGDTVIIDDSPKLGQKFLAPPSYLLRDRKKKKQSRGKGKQKAVDQDADEDEDDCWRHEDGLRAGDRVAIITRLFEDERGQKRALVRWFARPGAVWGPDGPDADEQAGQVLPYELYFTSDSTHLSEARILRQRATANPFSSPAASPTKRSRNDVITASPARARSVMGSAASQLSAAALFRTPQHSDPVPVSAIVSHAEVFSPSSLPDPTNPVITAQQQRPIPTFLCRAVYDVKPIPGASFWGDLNWDEHRQVAVQWYHRTMDAKEVTRAVDGWDVEAFMEESEEEDSEDERERKRKSEAVKERAKLREKQRLEAEKRGVSRPKKEEIVTSDSGFSSDAAESSDEDFASDSDGETGPATPSKRKRSGHLPTPSSTPRKRSRPAAGDIARAAKKRKLAVKSKAQQRKKKATSSTSGTGSHNPLPPLLASANLEALTPFERAKALLHVSATPETLPCREEQRDQIRSFLEDSILGRAGGCLYIHGVPGTGKTATVHSVVRELQNDEDMDGFTFVEINGMKISEPMAAFTHLWQALAPPSAPGPRKTSPKAALSALENHFANPDPARKTTVVLVDELDQMLTKRQDVLYNFFNWPHVPHSRLVVLAVANTMDLPERELSGKIRSRLGTNRIPFQPYTWNELKRILEARLSLVLPDKAPSSKDVPLFHDVALQKIAKSVAGISGDARKALDVARRTLDRVALRLAKESADSGDSAQAANAVAKLERGEIKCTIQDATQAYNDMTRQGPAAFVRRCSTMSKVLLLAVAQCVRRAGVPEVELDTVLSWHLDFLRQTSLCSSSSAPAKHELMDLVAQLHALRLITAESQRLDVFQRVRSGVDEGDLFAALREDEELKMHVPKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIN9</accession>
    <name>A0A2S5BIN9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIN9"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="191" mass="20616" checksum="42F2AD41F094D9CE" modified="2018-07-18" version="1">MPAETHGVDISGSRWQDMRQFAVLAALIQVAARSTESSVPRMRIVFRDAAAVAAILNASQAGPPVQSRRSSASGTATPEPSERQTAELAVLEEHFWPSGPAGHFSPFVFDVYVDVSSGHRFPDAGTLTHDLLEAVIANLPAEVPATIRWQMAHHRSDKEVALITLPLVAEHGQGLNWTYACLLTKVRSADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIY8</accession>
    <name>A0A2S5BIY8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIY8"/>
    <dbReference type="STRING" id="741276.A0A2S5BIY8"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="6">
        <location>
            <begin position="130"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="667" mass="69934" checksum="1445247BBB907404" modified="2018-07-18" version="1">MVRRPRCGFGLASVSTLATAYVALSTYLTYTPSHGTRTLGLFVRAANAPAGGAGGGSGSSGGTQACGWAYQCPQESPCCTEYGQCSAGVACLSGCNPQGSYGQGYCAPVPACQSNNYTFADSSRIQQNGTAWNGDATQFDFTLDTLDGSKPAIVANDELVLTLTQNGGGTKVSTTRSVLYGTISASIKTVGAAGVVTAFITMSGVKDEIDIEWTTNNTDTWDSNWFWQGDVGNYDHGATEQAKNRDEQYHVYTIDWTPSQLSWAVDGNTVRTIQKANQTNQRFPQTPSRVQFSVWPAGISSSPQGTIDWAGGMINWQDPTYLAQGKAFKAHVQWVDIQCYSGSDFNLPFVQDNSSSSSNSSSSSSRLRERAELWPRAQNVNSYIYGTNNSAGQIGVMGSNAGTIINSAYSTGQNMIISNGKTQGVKQGIGSGALADTVVGNWWQRQNTGVHVGIIIAGCLITLFLIVCVCTLWARRHRSRKTRASQATILAAAAGPRAGGSAGTTSSSATLSKSRNGPPGGDTVPLVQHDNRSFYADSAKNYSGYSLPGSRAPAYDRLRDEQYLGGGGGGGGGMAGRGTPPPPVPMVPKQYSDFGGGGGGRRNAPYGGPGGAGTGSARGGPPPRQQQQQQQGGRGVYPPRQYGGSRPPPGQQPNYPGSYGPGYGGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ27</accession>
    <name>A0A2S5BJ27_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ27"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ27"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015429942" description="EF-hand domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="401" mass="45419" checksum="170D37E862C78417" modified="2018-07-18" version="1">MPRLSRYRSSVSVALVAVASLARLVAAHGDHAEVEQNPDATYTELHMAQEHHMDSFDIQAFFHLHDLNRDGILDRNEIESIYGVHHEKKRKGAKNLEVHTQQANEIVDAVLARLDQNGDGLLTMREFVDGGVGGLPNFKGVEHLGHHYDAEGEYFLHHEEQFHNTPETQTEDSYIHPEDIEHFMSHEAIEHEEEAREREFTGEDPDIAPSDLGSVTPEQLQQHIFNELNGIPDEAETRDEKEFVHDAVKDEDAHNPHAEMVKPVPVKEMPRAVYNPQGGDAAAAAGDKSQQQTRFQRQSGPDDGSPERAPSPQERIRRERAQFARQQAAKFSQDAREARKRGEWGTGNADFGRPKDAADRLRRNIPYKYKVSQCEARSKIRLCETVHSQLSSQVRTSWFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJC3</accession>
    <name>A0A2S5BJC3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJC3"/>
    <dbReference type="STRING" id="741276.A0A2S5BJC3"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="190"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="562" mass="62361" checksum="B1C90BE75C9DBC48" modified="2018-07-18" version="1">MANLLRDLQKAKGDSVPEPERTYILALLGCLYYVYLRETDTNPDLNDPGCTPFQITASDAWSVICSSYRVGGLTPDFLSKHFEYFQRLLVFHCTGLTGKIPNGTRRDYVTATSRRLSACVDDLDVDPRPVSTSLNAHPSVQAEHPLSTLLAKMTIPLSPAPSHITVRPVPYAASVGKRVRNEQFGVIVAGISDINSLSSAEFQVVEQLLYKHGVVVFEDVDLTSAGQWALTSAFDPAAVEYGHGPDGKRDTRSILHKDLRNLSGTPVQLIGNGVVTDPHILQGLESPCQLAHPSHQSFHKTQISDEDSAKGFTRFYRWHMDAALYQRDPPKVTTLYGLEMPTSRRNIVRYDDGTGDELEVPLGGTAFVSGKLMFDLLTPELKSLAVRTRVKYMPHPYIAIGTAKSRPTGLGMESDGLEVPFEDLPPWEEEHVKIFPMCWRNPVTEKLHLQVHPSGVHELLIEPLPPTSKRTSETLYPDGAHLTDLKEVRDLLYRIQRPGIAPEHVYVVDWKPKQLALFHNRGCLHSITGAFAPEEVRAFWQCNLASTDVPAGPSAADLETYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZD5</accession>
    <name>A0A2S5AZD5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_7087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000169">
        <property type="protein sequence ID" value="POY69907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZD5"/>
    <dbReference type="STRING" id="741276.A0A2S5AZD5"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015411329" description="Peptidase A1 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="210"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="241"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY69907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="523" mass="54179" checksum="AF2DB4EC0B64B44A" modified="2018-07-18" version="1">MRPALLLAYVAVLLAPTTTAAPTPKVQRTITDSTLVVDASDAGTTIALSRPSSRLTRRDGTIDLGEAELHLARARAKFARGLANFEANTGERHFLAPAFADPSLLPPFDGSAQEAIGEAVEAGSDTSSSASPARRDKIFGESGIRLHGIPDPLPAPSTESSAAKRRAMRKRWVPNPKVIANPKFTGKGGSSSTAKTGSVGLTNYGDGTIFYGSLKVGSQGQAFTVNIDTGSADLWLPSASCNSAACNAHTKYDPSTSTTSALVAGKNLNIQYGDGSSTSGVVYTDNVNFGGLTATAQSLGVATSMSSGFQSDPYDGLLGMAYGSISTMGTTPLFQNLISQGKVAKSQFSTYLAASGSELYLGGMNSARYVAGSTHWYPVISQGYWTLAAKAIVAKNTVASLGTFNALVDTGTSVIVAPTASAQQFWASVPNAAPYGSGGYWTYLCATPPNIAFAFGTGFGELWTVSPQAFNLGRISTGSDRCVGAVVGADIGINAWVLGDTFLQSVYTTFDLSTNQVGFSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZV9</accession>
    <name>A0A2S5AZV9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1-acylglycerol-3-phosphate O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000150">
        <property type="protein sequence ID" value="POY70070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZV9"/>
    <dbReference type="STRING" id="741276.A0A2S5AZV9"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="525"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="65930" checksum="432B89F582F6ECF4" modified="2018-07-18" version="1">MLLDGVAGPVAEAAGASVDHIKLVLLLFLAVPLSLVYPYLPPSTKSPVVHLYSIGLITIFCCFVLPWTRGFLELVASCVVTWLIVKIGVKQKWGGSMQWIVFAVALGHLTINNIIVFLRDPLVTQIDISGSHLVLVMKLHSFACSVYDGQRPLEELDEAQKASRIPEVPGLIPFLGYTFFMPSMLVGPSFTYASYDAFTSHRLFAKEQAAGGQDATKVVDPTVIPPGRRRKAAKRLATGTFFLAIFSLYGGQYSMAKLLDPSFTKGKSFWSKFLFMNAASTFARFKYYGVWCIAESSCILSGLGYNPRTGHYDASRNLRIRTIELAPNFKVLLDSWNMNANVWLRECIYKRLAKKGRKPGFKSTQITFIVSALWHGVNPCYLMTFVLGGFCQAVNRSLRAGVRPFALPPGALNNPSTTAARVPYPKVELKPGEKDARPPKNLPKVKLQPPPQTPVKTLYDIAGTICTLTTLNFVVVPFLLLDARLSIRAWREVNFYALFMIFIPFFVLNVGGGLGVLKKYQKRRDRKRTELEEEQERRRLEWEDKEEQKRKRRGEGLPSFGLDVEDMLREEEEEARRALADAAGKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZZ6</accession>
    <name>A0A2S5AZZ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_6886</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZZ6"/>
    <dbReference type="STRING" id="741276.A0A2S5AZZ6"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="87"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="429"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="667"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="753"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY70112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1106" mass="118489" checksum="5C92CDBDFBC7293A" modified="2018-07-18" version="1">MSSAVGTTSAAAATSAGHHNNSSRPAVAATAAAPGAAGSTKPLVPAPAPQRPAKSEQRREGGRNVGPDGQASRSQHRREEPAMVGPWRIGKTVGEGSSGRVKLAKHKVTGQYAAVKIVPKPRKKDQDRANKMLLGIEREIVIMKLIEHPNVLRLLDVWETGSELYLIMEYVEGGELFDYLVRRKRLHADEARHYFQQIISGVDYCHRFNICHRDLKPENLLLDSEKNIKIADFGMAALEREGRLLETSCGSPHYASPEIVAGENYHGSSSDIWSCGIILYALLTGVLPFDHGDIRTLLSLVKRGEYYMPPELPTDAQDLIKKMLVVDPEKRIKMDDVLRHPWVTRKPPRLIYGQPPPAPPDVVQIARPVGSREEIDPEILSNLKTLWQGANEEEIVEELLSTRKTWEKVFYCLLYRYRTRNLENFNMEEEEIRKPPPPRRPAAAVEKKQHVVTAGAVGAKTRRSRTSISNIAAVTATAARTKPSSPSAIRTAPPAPRPGPTPTSPSRPGSTTPTASSPSKRAPRPLPPAPRSPQATPSTSRVPQIQLQEATPEARVGLAPPVGSSPDGNSSAWESLPPSPTPAATAQFESGSTSSRSSGGAPVLPIHIPQTGDAAMQQFFHDIVGQLQTITLRNSLAPSPALSAVSPAGTNVSSFLDSGASVVSTAPTTPALGSSTGGKAASAPTGYGEGDSSRFEDAEDDESEAGSAVSPAMFAALDFSYGAGGFASEHPHRASTPVSSIGSSHRAASPVLSVGGAASNHRRSADATVNYVRPRASVRASSRSEQQATSPARPGARQTASYPAYASTTSGVDKENVQVNAGLGFSYPRTAPPPPVAPRPGQQRERQTLGLAISGANGQAARGSSHRDTAFGDYEFVERPSLDEEEAMNMMAAPKIKKKRGTVSFAPMSPALSSSRPGANDPSVPKQSWFAGLFNWKSLSYTLMSTDYAHPTRLECKRLLEEMGAAVSIQNANGIAILKCRVHERRDASSLGPAKSAKFRIEFSSHSLSESTSPFLGSHSPDPSVTELRQQYPTLVTLVMEKGAHSTFKATYNRLRHRWTLDDPRATGGNGGASSPDPSAMINAMRLIPSPMPSPALGGPRSPRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZZ7</accession>
    <name>A0A2S5AZZ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_7025</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 9"/>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZZ7"/>
    <dbReference type="STRING" id="741276.A0A2S5AZZ7"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="11">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="11">
        <location>
            <begin position="132"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="272"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY69981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="571" mass="64698" checksum="5FE3A99ABD2920A4" modified="2018-07-18" version="1">MAAVPSSEKTGEIRSASSGGLHALTTNTCIVIGGASGDLAKKKTFPALFGLYQNGFLPEGIRIIGYARSKMDKDTREDKRWTNATPPSRCRRAVGAGGKGWEATSEPHVKMTRRECVTDDPRAGFTARPLLQDFHSRVSQYIKTPIPALKEKLKEFLERCTYISGQYDQDDGFVELEKELKRCEETFEDKKSPNNRVFYMALPPSVFTVVAANFKKHNYSKDGINRIIVEKPFGKDLESSREMQEGLKKEWKEEEIFRIDHYLGKEMVKNLLVLRFANVMLDASFNKNLISNVQITFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQVLSILTMERPVSFSSEDIRDEKVKVLRYIPEIKMDDVLLGQYVGNGDKPGYLDDETVPKGSICPTFAACVVHINSPRWEGVPFILKAGKALNEQKAEVRIQYKDTTSGIFSDITRNELVIRVQPNEAVYLKMNSKAPGLAMRTVPTEMDLTYKRRFSDLKIPEAYEALILDAFKGDHSNFVRDDELDIAWKLFTPILHEIENDKPKPESYEYGSRGPAALDDFIAKKVGYKRSEAPYTWPSTSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B041</accession>
    <name>A0A2S5B041_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B041"/>
    <dbReference type="STRING" id="741276.A0A2S5B041"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF9">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="10">
        <location>
            <begin position="295"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="418" mass="44442" checksum="5066E5C714B0B7CF" modified="2018-07-18" version="1">MRPTVPRRALADILKKRPDDVVFVTSLRTPIGKFRGGLKDMHAEELLSHVLESTRERLEAQGVDVQGGAVKDIHNGTVLMELGGAKSGRLAALDAGFPVSSGFKSVNRQCASSLQSVTDIALQIKGGLIDMGIASGAESMTRDYGTRAIPAGISPFIKKSESKDARDCLLPMGSTSEAVAEKYNIPRERQDEFAVQSHQKAKAAQDDGRLAEEIVPIKVRKVTPAEGDKPEITEEVVISKDEGIRPQTTMESLAKLKTVFKENGTGTAGNSSQISDGASAVTLCRRDVAEKLGLKIMAKWVGSSVVGVPPIIMGVGPAYAVPPLLERYGITKDDVDLFELNEAFASQSLMVMDTLQLDPKKVNPKGGAIALGHPLGATGGRLLSSLLYELKRTEQKVGIATLCMGTGAGKATLVVNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B086</accession>
    <name>A0A2S5B086_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B086"/>
    <dbReference type="STRING" id="741276.A0A2S5B086"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="224" mass="25203" checksum="416486D3BDE35F9A" modified="2018-07-18" version="1">MGIIVRRSLLDQMQQRLEECTEKFHGVTGGDGIISNCAALVRKVPLEKVVEEQLAMRQMDIRGDATRYLTDGSAPYLSLHHWTSWLHLIPGVEGTPVINLMTAAANAVGGPTFLRRWVFDNGAVTLSLGYAITVHREALTKDELGRIEWTWEHHEPRKPSRPGLVEGIEKHTYYLSQVEELLPGLHLFRHTSSQPGVVKGIREIDILWDARSELPSSSRPVWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0L8</accession>
    <name>A0A2S5B0L8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0L8"/>
    <dbReference type="STRING" id="741276.A0A2S5B0L8"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="1">
        <location>
            <begin position="65"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="153" mass="16297" checksum="469B4F9B2510C0E2" modified="2018-07-18" version="1">MRTASKAEAGRPALARLGLRLQTVDLAGGEALAPAVTSSPRSMTTLARGELYHSYAAMSAEPAAINKFRVRLKRRGETRAMSLSGEVTLADLLDRVRSKLATSGNLTLQFTDADGGSVLLKDEEDWQCALDVAQEAAVPPAWTGRLDIDVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0S9</accession>
    <name>A0A2S5B0S9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0S9"/>
    <dbReference type="STRING" id="741276.A0A2S5B0S9"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="752" mass="82677" checksum="B3AB4AFAA1A9A3FA" modified="2018-07-18" version="1">MEAEEKGTSKVPRRRQRNSAAPRSSQSPASATSREAISPTIVLPEYVPPEGSLKSRAPGRQNIACKGCRRRKVKCDGSRPSCMSCQVIYKEPCIYEVKATPADAAALQAEVERLSALLVRIKHSSALDRERLLAELETDGATPEYEPTASTSSQAQGGSGNTAVKRSASVAREADESGSGSDSHSPEDEVAAAMLSELSVAASGQVEHFGATSFLFRPALGAHPNLPATLGSPSSSHGGTLYTRDVPADMREHLLETFFAWQTVHCHVYRPALMRDLDGGPYCNDFLINAIYAHASRFSDRNTAGASPASPAAQPLQTPADFFLARAKDYLRAELDKPASLPTAQGLLILGGRECAIGNHSQGFLYTSMALSMAIDLGVHVDGLKMHSADALEIEVRRRLFWSCYVWDKSISVCLGRSPRFLKQDRSFLQPTADFDKIEDDLPWIPYALSPAHNLHEYPNYPLRTGVYFERMCRLSEIIEDVLLELYAVRRRSKCGEATLTRFNAQLDQWLVNLPADLAIASDAANSPPPNRITLALLFRATVILVNRPFSFGGWGPRIRVAEAVQSRAKQRCQDAANEITCLLDLYDRTFRFKNMNWLMSYCAYTAATIFIFDLRARTPGTAFEATRRLEIVLGALTSQTNVTPSVLKAVEIIRHLMANAPSSGETPALQTDPTVSKRLRFEEPSFPVLEPSFLLDSTLASGGEYRLPDLAQNEGPLLPEFPEAGPLSWLGPTDNIDWLESLDWLQTDNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0U0</accession>
    <name>A0A2S5B0U0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0U0"/>
    <dbReference type="STRING" id="741276.A0A2S5B0U0"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF5">
        <property type="entry name" value="BLR2277 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="309" mass="33877" checksum="02D5C293820D32A7" modified="2018-07-18" version="1">MAGFYEIPPVIEPKLLVQFGDEHKAKGIDTDWRGGSGAIPDVFLEGITSTPDGSLYVVDIPFGRILKVDPKSKEIVECVQWDGEPNGLAIRDDGKMIVTDYKKGLLLFDPKDNSIKPFLARRNLESWKGLNDLVISSAGDIYFTDQGQTGLQDQTGGVWCYTAAGRLHQLINNGISPNGIVLSPDEKSLYVAMTRDNSVWRMPILPDGTTTKANRFFMSFGNSGPDGLTIDEEGSLFIAHPSLACIFVVDKHGIPKARIQSSGTRPLVTNCIFGSGPDDRQRLYLTNSLDGKIEYVDWHCKGGTPIRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0Y6</accession>
    <name>A0A2S5B0Y6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0Y6"/>
    <dbReference type="OrthoDB" id="2528686at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="242" mass="26697" checksum="660D341921D0EC41" modified="2018-07-18" version="1">MTSAREASSRHYLDELDLQAAGRHFRQAAHEAETGGDRLGDIARRELRDGWETMNGLMESRPWPGGRRARHAADFTEWDGVKKLVGDTVHKVAEQAPVGWRATTEALLDENPSFARLSDRELRDDARIHADFARRYGRYALRDPTLPLAAQDGKQAIRQVGMVGRDAFEVARRTVGDRTLLPVGRLVFGASRREGAELLGAAAIAGASAAAGIALLEHEVRAVRRCRAQRNKSSSRRQAGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1E1</accession>
    <name>A0A2S5B1E1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chromatin assembly factor 1 subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1E1"/>
    <dbReference type="STRING" id="741276.A0A2S5B1E1"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021644">
        <property type="entry name" value="CAF-1_p150_acidic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11600">
        <property type="entry name" value="CAF1A_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 p150 subunit acidic region" evidence="8">
        <location>
            <begin position="371"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="9">
        <location>
            <begin position="603"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="645"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="943" mass="102825" checksum="290743B046804115" modified="2018-07-18" version="1">MSSSPAPASEGGGPAAPSSTAPTTADRSPVAGTSKHSSPDASSPEVLMLSDDDEQGDASSSSEEDDDEEKDADYDAKGKGKAKADTAAKRKAKASASSTPAAKKQKTSSTASKTASDKSKSAPKKKEEQPLVQIKKAKFDMRQKPLTTNLAESYTTEMHAFGNWAVEQLRDEGAKELSEYPEEHHGFIAKLVHESNQTLMGLATSVKNTLKTAIAAKLATACEDSQEVEENEWDEAKVGEKLPIAPIKALIQSVATRTNYGLFTSDLPAPLPSASKGDAGKKDGSPAPEVPAGLQIWCWEVEDDKLWVKEFAPRLEKRKAERQETRRAALELFKSLPASEQQALLDGKSSDSNSKGKEKFQGDSAAGKAPKAKKKEQTEEEKKAAEEKAAARAARDAEKESKRKERDEKRAAKAEKDAAEQAKKDEKARVKAEKDAAEQAKKDEKARIKAERQAEEDKKVQLAKKQKNMFTSFFVKKSASPAPAEAGPSYSSPAKSAVIDFDRVFHPFTVRERVEVAPVNRFRQPDQSYEIELDSKPGLTLQDSLSSFLSTASKRRIPPYNPYPEPPLSVRQTVNAISDATLTSQDVSALYNALKDPKKTRVKLLKFKEDYRPGYVGTWTKRSVMVGPRTPFARDTAILNYEHDSEAEWEEEVDDPDAEDVASDGERSGDEKEEVESDVDSWLAEDDEIEYQEGYDADGDMVMQAADNGGRLPGEDDDIVVVESEKTKKKKERDAKKRKADRDREKKREIMLPVAKGMFWQADVEEVVEPAIKPMRIQLLNGKSRAVSAPCDVPTDSVFGLNPFTFVSKPFVTPAAAASASGGTAVPAGKENLGLKGFLVPSDAAKSSVPTLSAGSVNTLKAKRAPPKKPFPTEQLPALLRMLHGSIKTKPVLINDFFELMKAQATPIPKVTIEAKIKEIPCAKVKSKTLVAPEFLAQYGIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1M7</accession>
    <name>A0A2S5B1M7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000102">
        <property type="protein sequence ID" value="POY70692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1M7"/>
    <dbReference type="STRING" id="741276.A0A2S5B1M7"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="486"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="752" mass="78335" checksum="194F1671BF7B9EC8" modified="2018-07-18" version="1">MAISHGPYHWLWLPPAPVRTDKAISALRPSRLTLFSGLCTHTSLLIVGPTCVASELFLATRSRRSQEPPSPGFALPFARLQRTGYVFPEQQQHETRSAQATMDSADLPTFSLGLDTPSKYLGGPSTGLTPASWSLGTGFTPSILGGYSASGWTPSLTAAAGAKTEFNPFEISLDATSSSTSKRRAFGADFLDRDEAATRGSTDSVFDLLATTPGSGGRKRALSSPAVEVGAGNTSFPFLSQPSQFNPSPAALDRRTKRPRMASMQSSNLTSQEAFFSSFERESDESPASSVVLTPPDSAPTFAGGSPARKDIAVIATHVSKQVPPTAPPQPQQPLSALSRLAQERSALIARGQTVLSQASPLPIKQATPATAPLAQADISVKAEPLEDSIASSRPGTANKPAPLASRPPVTRGQSRRGTRSSIAVGNVASTSREVASPSPAVSLPTKRKAPRKKSSSAATATAAKRKEASVAAEDDDDDEEGPEGSDKRQQFLERNRVAACKSRQKKKEKVAGLEQFAADLCARNNILQQTAFALRQEALALRQLVHAHVGCSCEHAQGYIARDAAGGGIATIDQLAGRTLKLDYSVPPAMGTEDDVYSFLDNGGAAPAGMLDSPERGKSLAPAATSGPAIPISGRPSAAGGAGGPSTSSSPVRRAGMTTRRSSQAVQHSQRASYSGAGRTTHGDAAFRAAVQNNHLGLSMNGVPMDGDLASSILTPGMRATSAPPTTPGWGDAAPSGDYFAPKRKSIAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1P9</accession>
    <name>A0A2S5B1P9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000098">
        <property type="protein sequence ID" value="POY70708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1P9"/>
    <dbReference type="OrthoDB" id="5569309at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="436" mass="46997" checksum="B64F5FB436919523" modified="2018-07-18" version="1">MVNYSGPLLAKRKDELAEIARQLDLKLADGVLRPEIIDRIRNELKSNSRARQDPRFVGLWTSMRESRRLEGEDTPDPNENAIDSDDLTEQESSEEEQEQLGDQPTAAVAHSPRRQQQHDEAVADSPVTTYRDALLHNKIVDTLLHGQPADFDPHHLVEQALVPASQALVRPARKSFSQIARRGSVSLRYAARETVTIVEDVQGKASQTWVVVAAILAAEMTWLLYEAIPWIETHFGPHDWLHRAQTGAFTLRLPALSVVLHPSFIRAIVAWAASTYLLPLLVATLISFPTSGGRTGGSSGGNYGTPSRGGARGRFVANGKRANGAGGKAKHQHLSPPNAVIFTLVRLAIALLKGYILPSSTTAAASASATVASTASTALRNLGQLLLDATHHQRATGVVAEIAGWSFAEAVEGVWGVVAVGMGLGAAVGIYAELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Q5</accession>
    <name>A0A2S5B1Q5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_6297</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 12"/>
    <dbReference type="EMBL" id="PJQD01000098">
        <property type="protein sequence ID" value="POY70713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Q5"/>
    <dbReference type="STRING" id="741276.A0A2S5B1Q5"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY70713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="360" mass="40724" checksum="1F3F891B967B2BFC" modified="2018-07-18" version="1">MADFVKLQIFGTVFEVTTRYVDLQPVGMGAFGLVCSAKDELTGTMVAVKKIMKPFSTPVLAKRTYRELKLLKHINHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARLADPQMTGYVSTRYYRAPEIMLTWQKYDVAVDIWSAGCIFAEMIEGRPLFPGKDHVNQFSIITELLGTPPEEVIQTICSENTLRFVQSLPKREPVPFAQKFRGADSQALDLLEKMLVFDPRKRIDATQALAHEYLAPYHDPTDEPVAPEPFDWSFNDADLPVDTWKVMMYSEILDFHNIDGNNAASGPVAGATTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1V5</accession>
    <name>A0A2S5B1V5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1V5"/>
    <dbReference type="OrthoDB" id="2529425at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="645"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="876" mass="95369" checksum="2F9D3EC4495BC221" modified="2018-07-18" version="1">MPSYPALNDRFPTCEAFLATVNSATFWLDDSGVSVQAEHTSRKTAHGKKVTVRCKLGRRKPGRKTGKSAGKSGADELCPYARSRALTGRAGGCALLPYRFRLIAERDETLTGLGDFVVIECEPHTTSLHERHLFPSGDVDGVVVTAASTSSEAAPARDASGKFAARPVPRGVLKEVYDGEPIFVPEEPTVIDDVLYLRSGFAVPLLPSKRDSGGTAERIRPKRRNESSLSHKQDAKWDAWETRMCPDGERPAKRQRIRGAGGEDALRAWGWVRGLGDEQVEADEPEPVDDGDVEGLGASAQRVQRDDADEDVADVFKPLPSAGSQLSEQGSSARIETARLRSFGSRPDNVDIDPTEPPTKSNQQPPSPFPARSRFLAQNLDVDDLSEAMSRSFSIDFQHDTPETSFSPTSPAPLRPDEATAAAVPEMAASIAASEGRLPPSELVTIKREEADHAREQLALEALVGLSGLLVEEYSDLVPGLKAEEDGCSSAQASPEVADISATAVDEATVPDVERKLEDLTEECREPAPPTKKRSPRKLSRWELPGTMGEEDVVVISEPGPTIRDDHEQDEKKPLDEATLSVAPSPSELPSKASALTFVPRSSKKPAGHRALLKRPTPIGATPVGDSHATSFSSPQKALMAIAQASKANREADLLERARAEQMAAVVKAEPEATEEEKLAAEIAKEQRQAEDLQHLFWKSGGQNEGGKIDRAVALDYRMALLSQRAPAFRPSQELSAPSASIYLALLSQPCRPARHRLPSLPAFPPRLPDRPPESPASSQSPTDRRNRTGQPSEQTVRPDKRQLLALEYLYGRAVGLDECAHLEKHEPATWRLVRVMAGVAEVNEWFRRTEQNAGARSRGTTNEADRDRKIGLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1X0</accession>
    <name>A0A2S5B1X0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1X0"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13704">
        <property type="entry name" value="Glyco_tranf_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57957" checksum="36C472F4860AE2E4" modified="2018-07-18" version="1">MPPDFRRACKTGAEVSSLSAGPPLLGSVSATGSDRTCPRSRSRRMSWTKGPRRKAVLSLLGVAALLLLFRSTGRRSSLKALPDASRTSGSGHRYEDYVAHPSETAALPLISSIASFSLPKSAQDRVNVSICAIATHEEQYLPEWLTWHRLVGVERFYLFHNDPSLEMRRLLRPWIEEGSVILFELMYPEGTDIGSVYQPDALRMCENFALPNTNWASHHDVDEFLMVDAPGWTSPVPHPVPAAVSTGEKSEPSAAQRFAYPLHARFATLLQAATCLPILRIPFQNYGQRRLPLDAFLTERQTVRDKLPPGYHTYGKMFIHSDGDKQRAGWMGPHSCRKPPGTVVMDADGTRIQLGQGAYPYDGLPLPQEGVYLFHYVQRSLEDCERKFHVVSGTRQDWRTRDGLDGCARNYVPTDHDLADPAARRALEALPHGDLVLQRPDGWNELFIRDTSARDSWQGRMTRAIVNGWREQSLTGPGEGWFWEQGDEASEESLMGLDNVWLIADVQKATVANAVLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Z5</accession>
    <name>A0A2S5B1Z5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Z5"/>
    <dbReference type="STRING" id="741276.A0A2S5B1Z5"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF185">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015478132" description="FAD dependent oxidoreductase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="468" mass="49533" checksum="F6102EB23BC6AE9F" modified="2018-07-18" version="1">MTQPRRIVVLGSGIIGLCSAYEVLHLSSDAHVTLVEASPSHLIAGGASSYAGGFIACGAEWHDEPSRDLARLSWQCHTELASKFDGANAYGWRECGAVGLSVGGHSESRSKYRSLPGAADSAAQSQNRNWVEGDREELSTEGGVAQIDPADFCQHLYAHLRGAYGDRFGTVFGRATGIEAAAPSGGASGAASVSRAVDSARQKILRVSTGVDGQSESLPFDRLLIACGPWSAAVCDSLNLPPIPLTNLPGHSLLIRPATSTTHPVDVELPSEAVFAGIDGSVGGVHASTSGLARGLTDEEKREGYTRSPELFVRRRRAGADREWIYVAGENSIPDTPLPTPTASGDAPPLPNRLPATVDAVRDLLDEQCIGRLKRAAGAVSPLLKEENGARIERQQFCYRPISSDRQPMLGPLRAPDIFIATGHGPWGICLSAGTGRVMAEYLLDRPLSADVSGLGVERFNIEIKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B216</accession>
    <name>A0A2S5B216_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BMF94_6222</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B216"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000391">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="22">
        <location>
            <begin position="455"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="168"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="623"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="738"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="810"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1405"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1555"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1028"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="687"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1415"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1569"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1599"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1617"/>
            <end position="1638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="POY70810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1697" mass="186863" checksum="19525E03C93E6AD3" modified="2018-07-18" version="1">MESIPKHTDAQRAPTPDVDSSRPSAARSHSAVVGPDVEYQRHTDQLAANADNESLSGRGRGGQRFGGMGQAGIRDGNQDEPFGMQRRPGAQQDETKQSDNTAELERTGFAQPTSAAPTAGSDSDGVSSDEESRAAARALKRHRGPAGLIDTEAEMGIGGAGYGRMAASLDDAEQRKEQEKGGNSKKFWSGGTKSSTGPGGMGSGYMRMIHALAKEDEELERKARHERRKHRHRLRKLRHGDKENDDGTDKESEKPAKSAGDELATYASPPEHAATTPTLARTQECESPASPESRQLEADLKKNERKQKRRAEKNSRDSGDEADMTKSSLLAIHRPIQQRRLTESGVLSGDEERDRMPLDPAKIREIEQLQEEETRKNPGMGSRQGTSSTLASIDTVERREKLSDKLMDVFSLDEPEEVVAEYPCWLFRSILMQGFLYVTAGHLCFYAYLAQKEGATIRSGSLSVRGSKTRRYHKHWLILKDSILSWYPSSTDPYFPDGHIDLHYCISVEESRFHKHHFKVATADKRWHFSADSEASRNEWVKAIKKVVFRCQNEGESVKIAIPLETIVDVEKSSSIEFAEMIRVRVYDADEGYSLDEYYLSYFKDLDAALERINSVLEAFRQHHPQGRGSKGPLPPAAGHEHLEDTTKNTTADIGEVDDYREASSKATKEEKPVERSSTKSLGARVSSLLTGKSGKTSSTEKSPSSDAASIKSAPPTTTAAATDAPVLVAANPPRIDARPAWLPSPKPAPLVAADSTRQPAGGSPPSGWVATLRPSPEHIDVSTVDNRDDVALQGASPLVAVAGTLPQAGGPAAAMESDGTCPNLAPTLSNQPQTQSAASRSDDALASRDPMHAHQAHTYPPGPATSTDDDPATRGSALSRIFSGSTSGGRKILESVTVSSLPGRRKRKDETAEGQVVAEPKSEKEIDEFRKTFGLGEKEELLHDWPAFLFRGLPISGHAYISDNYFCFRSAGLLASRTKMILPMTDVIGVKKHRSYRIGYSGLVVVVKGHEEVFLELSSSERRDACMAALEDQRDLVKRRRKAEEEAKGEKQDSEHQELRELVDLSATRDADLTSPEMPHPQSEAIANQPPIMFSSTTSDFVTFRPEKPLRFTCLTIGSRGDVQPYIAICKGLMAQGHHCKIASHAEYKKWVEGHGIDFAPVGGDPAELMQLMISHDFFTISFMKEAVSKFRGWLDDLLDSAWEGCQDSDVIIESPSAIAGYHVAEALRVPYYRAFTMPWTRTRAYPHAFAVPEVHMGGGYNYMTYTMFDQVFWRATAGQVNSWRKKTLKIRSTNLDAMQQHKIPFLYNFSPVVVPPPLDWRENIHVTGYWWLDNPDDSNSKKWEPPEELLDWMKEAESKDTKVVFVGFGSIIIPDPLEMTRVIVEAAEAAGVYAIVAKGWSDRQKDDGEDTEESKKKREENEAKHSQIMDKPYIFQVKSIPHDWLFPRISAAVHHGGAGTTGASLRAGLPTIIKPFFGDQHFYADRVETLGIGSHITNFDVEHLTEALKKATQDETQIERARLAGEEIRKEDGVATAIECIYRDLEYARSLIPKPSERGKDGVPLESESEDDDEDDAADESSSDDDFSSSDDEDADEEKKSSAPHRDRAQGSSEQSMSADTSAATSQQTESRTTSSDEGWDVMSRGSAVESDSRASSATRREVAPAPAVSADHSPEGTNAGLLGRTLGFLGKPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B222</accession>
    <name>A0A2S5B222_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B222"/>
    <dbReference type="STRING" id="741276.A0A2S5B222"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF4">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="120"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="761" mass="83868" checksum="8E48255975001B4E" modified="2018-07-18" version="1">MATAASLRARKDQIVQQYSDNVDLVTQVQQQALEEVVAALRRDAETSFEDGDNVRNPERDLQASAALEDEQLDATRALLKDKVTVFRFCRRARFSPPAALKLLHATCQWRLSSSLLHLTPASISSLYLTKPLFFFHPDLRDRFGRPCAVLNLRHVQRTPDGKLDALKEFARFGWEVARRYLSDLSRTAAHKAQDPTLQMVVIVDLDQAGMSNLEVELLPFFLDLLKNNFPGMVGAIFVLNYGWAYAGMWQLAKRVLPNTALERILFPSKEELLEFFDEENLLVEHGGKLRYEYSPDNPILHKYGQCQLATNATASPFASRAPSRATSSSSLHHEVFHSAPGSGAGTPSLSRRPAGLAMTMRDDSEAVEEATASWFPFAWSKRARQSPRPPAPLSLLNGGDVTPSGLRRVRSLAELQQRLEQTQREIDSEDSIDESGSEGGPGDEYTEGRAYRRTAGTGGTADDDTPAYSTGASTAPSASSSRYSSRVGSRAVSREGSPSRYRHGIEPLTTTKGAALQGQGGDLAILSPYNTSNPHFGYPAYLPPSSLDPSGTPRSRFPRRRKRDLVRTLTYLAALRFLALHRSIQRRLNALIVVLFRLTGLGWWQEWRHRSAARSAGFGSVGDSKDGQDKKVHWKTGTTGSSPPVSSHDSSSSSLSSIAPPPPGAHVPSHHLHHQHLSSALVPSSNSPPSPLINIDPSVFYLTLLFLIVRTPDRIDKVKQLGYLLAVKMPTWSAAQARKILLQLLIGKARAEAVLRAEQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B236</accession>
    <name>A0A2S5B236_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B236"/>
    <dbReference type="STRING" id="741276.A0A2S5B236"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="182"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="661" mass="74817" checksum="43C4842EC52163E1" modified="2018-07-18" version="1">MAQNAPPVPAKALRAPATRVTRSASTLSKEVEPSSPADSPAKSAATEERRLGESDQDDDAEDEIILAELPSQSHDSALSSQARRQLAPAGSSALEDRDLVMDAYEDEEYSGDEDDENIYVDEEGEEDEMRDGQDDGEAQGEGDESAEEESEEEDSRSEGELQSIRYEMHGVEEAVPALAGKYKLVDRLGEGTFSSVYKALDAYHDEFDNSQWRPVARKGKVYVAIKRIYVTSSPIRIQNELELLYDLRGAPNVAYLIDAIRHEDQVLAVMPFNRHQDFRTYYRTASLPFLRSYFSCLFRALLSTHTLQIIHRDVKPANFLYDVTTGEGVLCDYGLAQKIGGDEWFEWKSDCLHSLPGPTWGGLDGRQRAMRKMERDPSDAPGLHSGLHGVRLREPLSLYDQALAMEDAWNMWSRHLKKAAGTEPLDEKSLDTLEAYKPWIMPPGWRPDIKKRISDRQEFYKSWRPAVQVAAQKAKQKPGYLKEDRRPSVRANRAGTRGFRAPEVLLKCPDQTVALDIWSAGIILLCFLTRRFPFFNSNDDTEALAEIMAIFGRRKMERCAALHNRILQTNIRDYDEPPYADLHALVRSLNPPIVVENSPNPYGEIPASDADISDWYAQSELLDCTKRWTAQECLEHPFFRGAYDIGLGRTQFREDAFLHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2C5</accession>
    <name>A0A2S5B2C5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2C5"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="770" mass="81383" checksum="9D7B52E866342086" modified="2018-07-18" version="1">MSITMLAHADFPFPLAASLPLLVDPAPQDYIQIDPALLAISNNPPPAKPEKVKRARGSGGRKRRKVEDDENGSERIPKVKKPRKKPVRIPQPDAANAADGYIAYHPYATANTLGRYTKLSCENCRTRKTKCSRHLKCLSCVARNEECVWADGPPIQENVKHVFGSTEDENRRLSRLVTILSARYSAREAVLAASEHRPPRPAPTLDDVPSRAPRREPSRAPTRQQEDLPVEIKDYSDYLNRFENAGTSALDDARALLALAAPSGSSTPQADEEAGVGLDVSAAAVLAVAQAAEEPFPFALPVPPAVAPPSKAPARRRKLPKARTTSAIPRATPAQPTRSGSDSLDRVLQTALEAYVSLNGDADLGELFAQNDDDAGPVDALTLLDHSAFEPVAEGAQQFFPTAGDAYSTLPFYQLPLPVPPTAYRVPGSAAMTQSSGFAPIGLSSSAPLKSQREIASFLTAGAAAFRQKDAPPQDCPQTDQNGRAGLEERAETGALPASGELEEPDSAAGAASGSTAIAASSPMRRDRGDPMLLAPIRTNSISTISTIPPIRRSSWLMSPVASTFAPSRPVLSVDAAGAFARLAHEGNFSFPGSGAASAGGGISALFRRSSMNLHNGSASTMTPLRSAVDEAGLRPMGSSIRLWRQADYNDSRAGSPARVASPDDMLDERFEPRAEAGGAFAGPANAFEGLQGDWAPFLPRLANEVERTDLTLVEKPEEIEADLAVDEAKMDGPEVAGEAGLAQRTSESSLRGTEGGSGADLAPCTDGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2L7</accession>
    <name>A0A2S5B2L7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2L7"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="166" mass="17300" checksum="2F71D694232868CF" modified="2018-07-18" version="1">MAARSTEQLLHGQLAALSAPLSDDSLRALALIVGPAMLLEALDLIDKDSVARILPPNGRPIYQVASSSGGQPYTVYPNVPKGGGFCPCPAFSYGVLAQGNQVTCKHILACRIADRINAWEHKRVGLEWLAGLAIKFGTAVPPSLADSQGAPTSTLQTGIHASSSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2R9</accession>
    <name>A0A2S5B2R9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2R9"/>
    <dbReference type="STRING" id="741276.A0A2S5B2R9"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="81"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="670"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="827"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="882" mass="96294" checksum="82A350FC7F49086B" modified="2018-07-18" version="1">MAMTLPTIALPPDAASEPPAQLPELPPELLLTLLTKRQAATSTSPASSTRGSSTERDALDSFVLSGAGASGTSAGGVQVEDVLNELLPDEASLSQAALIGLLLRTKIQVLREEVELLTDLLDRDQDPTTMGHLQELIGDLLSQVTAIRDAATESEVVVREITRDIQSLDLAKRNLVASMNALKRFQMLVNAFDQLTRLARSRKYRETASALGAVKELSAFFKTYSSVERVAAVSRGVHEVQNVLRAQVMREFEESFANETARAGKDAQLTDACLVIDALGVDAKNALLKWYSLLLLRDYRRIFGAASEAGQLDNIARRFAWFRRVLKSHEEENAHIFPAGWNVGAVLAAGFSEVTKNDLKSVLAKSSASLGVGLLLESIAQTADFEREMARKYSLTFEEILRLSQISYGVVEADQPISSVFEPHLGVFVEAQDKTLSEMMQNFVSSRISISPSDNPSAVLPSSTELFYFYREALERCAKLSTRQPMLDLCKVYRKWLKTYAENVLTAALVKFDRKSSEGRPNMQELHTACLVLNTAEYCHETASQLEERLQERIHPDFKDRVSLEAEKELFTSATSAALLAILRELEFTVEPCFASMERNPWKEVEYVSSESGYVAELTKALNSVVDAVREGVEQKKYVRSVCDKIVGLVLAKFTQTIVRCRPITQIGAEQILLDLQGVKNTLLHLVIAPGDTAPIPTSYSRYVARSVQNIDTLLKIIMSPDDPADEFVRHYLLLVPCQSFSDFQKLLELKGVRRAEQNHLLDVFLAKTSTASGLSDTSFLTTLDMDPTSNSLTSPSASGLQSPTIASGTRHHLGLFGFGGSGPSLPGLPGVGGTTGASREASRAGTPAGTRDQGQEKGPAFARLGARFGTRFFGGGGAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Z4</accession>
    <name>A0A2S5B2Z4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5468</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Z4"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Z4"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="262"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY71158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="455" mass="50378" checksum="24BC403098D4F664" modified="2018-07-18" version="1">MQNYYAGNPLNRLSYLRSSPSFLASALESPKASFIPLDSLQPLCKNDKDGVRRLLTIKWSDVQEFIGDPKQVFHGVDGKRDEDVPELAILGKEAARLGKSKVGELSPQEKRQYFLNQPALVFLGVDERSAPESAKSLPLSKPDDNSTLESHSPHGEPYWAIDVSSCTELKKQILIKNERAMFMELRSGAQTMPNEEASIAAEARSLVDWNTRNRFCPACARPIRSVWAGWKRSCIPGEPSGEGADAEPACVSRKGVHNFSYPRTDPVVIMAVLSPDRERILLGRQRTWPARFYSCLAGFIESGESLEEAVRREVYEEAGIVIGEVGYHSSQPWPFPSSLMFGCWGIAESADAEKDVRVDLDNELEDARFFTREQVLKVINSTKPMQLSREQIAKIDGQGGPARDELDAAKRKADEQGAFMMPPATAIANTLVTAWATGKLFNQHPASSTNASSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3E8</accession>
    <name>A0A2S5B3E8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative Glycerone kinase</fullName>
            <ecNumber evidence="16">2.7.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_5611</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.29" evidence="16"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3E8"/>
    <dbReference type="STRING" id="741276.A0A2S5B3E8"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="15">
        <location>
            <begin position="6"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="14">
        <location>
            <begin position="417"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY71299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="623" mass="66115" checksum="845129D39F0C7E1A" modified="2018-07-18" version="1">MTSINEPKTAVADALAGLSYLNPDTKVVNRTTLIVKDPKPSRVHVLCGGGGGHEPAHAAFVGDGMLSAAVSGQVFASPNAAQVEDALRRLDLAGQSRGTLIVVKNYTGDVLQFGLANERWAATHLVEGGGKPDDDDPHQVRLVVVGDDVSVPRSQGALTGRRGLAGTVLVYKLAGALAAQTHVPEHSLPEVEHVARVVAESCGTMGMGLEHCHVPGTETSEAYLAQDEAEIGMGIHNEPGIRKVSPIPSAAKLVDEFLSTITSTTDSERSYLPFKHDGQDEVILLVNNLGGLAEIELSIVAKEAAKWLKQKRITVRRAVAGSFMTSLNLPGFSLTLLLLPRERVVIPETSTSSSILYVDKELMLDLFDAPTDAPAWKWTFKGDPEMTVDEEEDKKKAAKASSEQSSGVKGPKPSDPKQFLRALESALKSVIAAEPEITKYDTIAGDGDAGLTLKAGAQGILDAIGENKIPDDDVVAAMVACSEVVEREMGGTSGGLYAIGLSGLSKGLVEAAREKDSKVATAEVWARGLELALNTLYRYTRARPPSRTLVDPLASFILTFSSDPSNLTHAIKAAQEAAETTRDLDAKAGRAAYVDQEKIRDAAVPDAGAWGVWKLLEGMQKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3I0</accession>
    <name>A0A2S5B3I0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3I0"/>
    <dbReference type="STRING" id="741276.A0A2S5B3I0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="214"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="5">
        <location>
            <begin position="286"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="292"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="526"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="570"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="646" mass="70192" checksum="4A1973D18F8C0C25" modified="2018-07-18" version="1">MASSSSSTSPATWQQDPLHPIAVLLDELRAEDVTLRLNAIHRISTICLALGPDRTRSELIPFLQESLDDDDEILLALADELGKSFVEYVGGPQHAHVVLPILEHLCGVEETLVRDKAANSANEICSVLSQQQVDEHYVPLVRRLSTGEWFTSRTSATALYAVAYPKATAPVQDEAVKMFSKLCEDDTPMVRRAAAKALGDFSKQLSHDRLISDLLPPFRKLSNDDQDSVRLLTVESMISIAETLNDDECKSLLGATMKALVTDRSWRVRYMVADHFVRLAKAAGSDIVRDELVSAFVALLKDNEAEVRTAAAGQIPGFAQLIDRDAILSQLMPCIRDLSTDASQHVRAALGSQISGLAPLLGKDATIDHLLPLFLQLLKDEFPEVRLNIISKLEVVNDVIGIELLSKALLPAIVQLAEDKQWRVRQAIIEYIPLLAKQLGVAFFDDQLANLCMGWLGDPVFSIREAATINLRKLTEVFGVGWAKETIIPKVMEMGQNVNYLYRMTTVFAITTMAPALDVDSIRSSILPAIVTLSTDRIPNIRFNVAKAFEVLSVSLASQQGGRDLVSSEILPAVDKLRSDSDADVRFFAEKAAEKAQRVVNGEDVSGGSAAASATPPPGGASQPASGVAPALGQQAVSEEVDMADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3Q6</accession>
    <name>A0A2S5B3Q6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3Q6"/>
    <dbReference type="STRING" id="741276.A0A2S5B3Q6"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="581"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="793"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1050" mass="113841" checksum="1617E2B1FD79B88B" modified="2018-07-18" version="1">MEDLGDAASRLDPTANNLSSAWTAPPPGQTAPDTTAELEERKAAPFLPDEVLQALARDPPPLSTATAARSTHSGTSSARQSIAFDRTFLMDVPGLATPAQRDSQSMRGGNSSRSAQSTGRVSPSSPVTSPRWTNVATSHERRKTLRGLVSNRVRLSTLGPGSLADNALVAAQPAPNPRSRQSRLKAPEYASAWSRIAMAASAPALERSMSASSTQSTPLASTASITSTSSSRMMRSRTADGKLNLGDQGPVRSPGTAPTVDDTDLDRALADLDLRAPLRQADRDSRAPRQQVPFPQPNEPSHASLEPSSDSRGDFLVVVTGPRGVGKSTLIRRTFKRSGETLRTLQRPDAGAEAVMSSASFTMAGIRRTIDIISLDAELLESDPARGTSWPAEVPQAEAVMLCYDASDPDALLGLSTLLQTFWSGGADVPLIVLACKSSEHDAIDPEAAAELCNRYGAGIVRLDGGAEDPQRKAKESFSWLIRQIMDNRGHFPFQLSSRPETKLIERSGRAGETHFYASLATPAESGPREHYFPSPPPQPPIELSPAQASIGDAEPTIRLSVTETSPVAIAPRPEKRPSFARRNLLFSSEDLVDKFLFASIAGDDDDFVNAFLITFRRFVRPARVLEQLVERFDFVSRQDSNPMLKRYGQLRLCSTLSTWIQFYPGDFSEADALGVLRPFVSYTLTSSDWLQHYAFELAPLLPGLAHGSDPDLCWSTPLPPPGAPRATPFLRTTETAATAFDVSLSSAAGSSDALSLDSRGSSTGASSAPMSRQVSAVSAMLVDASNVTSEMRAEDIAVQITRLAWRTWAGITPRDALRHVLAKRDRSADSRVMRCVGFVNRLARWVATLVLVQSRPRHRALVIAQLVLVAAELRSQENYDSLAGVLAGLNHQAVHRLSDSFRAATERLDGSQAHTENDTRPKKLRSLNLLLSPSKSFAAYRLAISTRSREAVPYLGVVLQDLTVINETSSDFEQDLVNWSKMAQLGESSAILLDCPRNAPPLPSDSVLEAYILDLPLLDDEKLYALSYAYHPRDQKSSPARSRLQEWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3U7</accession>
    <name>A0A2S5B3U7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3U7"/>
    <dbReference type="OrthoDB" id="10613673at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="303" mass="29982" checksum="A3EDE2E84F4AEBD2" modified="2018-07-18" version="1">MLPGPGNLTPAPTPPPPSDVPPRPNPAATPSRSSMSRVTNAQPLNEESDAAMGFAGEEVGSAASSESSVVDDLMRDDELAEANEPAHGGDEAMLTDAGADEVIASGTGGPALDYPASPSGPSGGSSRRAGGRPYPTRAGSGANASSGPSGSRGSRRERASQMFSNGGGEFERERAALEGRRGGGSGSMRLGGEGEGGDAKSPEEVALSKVIDKDYVGKLHTDPFWAQACAIRQARGAAGPISSTAETSGAETRRDATAVGGATVPADAGTAGTGAATLPPPVPAAATADSLPYEGEPATEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3V2</accession>
    <name>A0A2S5B3V2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="1">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3V2"/>
    <dbReference type="STRING" id="741276.A0A2S5B3V2"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="643" mass="70096" checksum="88701248741DA863" modified="2018-07-18" version="1">MSAEGEIPQLVDGAAADDVFEGAIGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFTESERLIGDSAKNQAAMNPKQTVFDAKRLIGRRFDDQEVKKDMAHWPFSVVDKDGSPYIEVSYLNETKQFSPAEISAMVLGKLKETAEAKIGKPVKKAVVTVPAYFNDSQRLSTKDAGTIAGLDVLRIINEPTAAAIAYGLGEATEKSQKEKMVLIFDLGGGTFDVSLLSITGGVFAVKATAGDTHLGGEDFDNALLEHFKKEFERKTKLDISNDARALRRLRSACERAKRTLSSVTQTTVEVDSLFQGEDFSASISRARFEEINATTFRSTLDPVEKVLKDAKMDRSKVDDIVLVGGSTRIPKIQSLVSEFFGGRQLNKSINPDEAVAYGAAVQAAVLTGQTSEKTADLLLLDVAPLSLGVAMQGDVFGVVVPRNTPIPCNKSRTFTTVEDNQTTVTFPVYEGERVTCKENRLLGEFELSNITPQPRGQAELVCTFEIDANGLLKVSALDRTSGRRANITITNSVGRLSSSEIDAMIADASRYAQQDKEFTAKHEAKQELESYIASVESTIMKIDVSPRNRDKSSSPEIGSKLKRQHKSAIEKELAAALERLEIEDSSADELRRANLHLKRAMQKGMAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4P6</accession>
    <name>A0A2S5B4P6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4P6"/>
    <dbReference type="STRING" id="741276.A0A2S5B4P6"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="446"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="656"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="698" mass="73868" checksum="F9E7AB9DE6AC1A08" modified="2018-07-18" version="1">MGKSKTKAATATADSAAATPAAPAATGLSSFLLGQAPGKDDALDDIFAHSKGPSLAFQPKDKSIAPAKGKEVASEGSDDDEAQGDDDEDDEDDEELSELDSDAELSDENEADLEEAYAARMAAAKAKAHQATVTNKRKAADDGNEAGADSDSDQDADEDATMQVEDDGVMDINDIIAGSLAADDKPALGKQGKKQKDEGKKSAKLLKREQETPEDRDARTVFLGNILADCSTSRPLKKALVRHVLQNPALQSALPEGCPPLKLDSIRFRSIAFASKVFGRKATTGGGEGGEADGGRSRKRAKEWREAEGSDIRGVRGGFRAREGDDAEAGPSRSTNGRVQPLTDAQKRKVALIRGELNEGKKACNAYLVIAALPESVDPRAVVRAVVEAANNSVFEGFTIHADVVRPRSAAALLAAAQMAAKPNENLTDVPRNSDAFQVAPSDARRTVFIGGLDFAESEETVRAAVESCLVRERGELPAGERYVENVRVVRDPSSGLGKGFCYVLLQEDSCVDELLALPPGKYLKISRRKVRLERCKTAAAAARAKASARTVAGLPARSGAAGAGASAGGAAAGGRPKPVRLAAPRDPTLAKHGKATNEKKAAHQAELAAALANLPSSERKQVKSLDAERIARRAQKKEQKRLAARYERKQANLSKKIGGGAEAILGKESRAAERHRKEKRRISTQSKSSIKKKKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Z4</accession>
    <name>A0A2S5B4Z4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Z4"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Z4"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="83"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="352"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="460" mass="51505" checksum="F90A9D7649102C80" modified="2018-07-18" version="1">MASWGSPTNGVPPPAYGRQGSWSATDGWSNDAAPPPADPTAGYSLATDANATATSRPRAGTQASGFAEAPQVVDQADWELAPLDRVQVALKGDMQGWAFVKHHVWTIVHPDKHTSVDRRYSDFVWLMDSLTKRYPFRLLPALPPKRIQVSGHYLATDDLFLERRRRGLERALSALLAHPVVKRDALLNAFMTETRDLADYRKTQEISLAEESTSRTLTPAEIASLPSDLDSRLTSVRQKVIPLVESWTRVTSTADRLAHRRQNQGKEFASLRDAFEGAVDLAQGAWRPNEVGQSERHIRSVATLAGEVAETNETSAQRTLDTVVESLKQHREIFINLRDLFGRQVTLGGDNLEKLRRRLDANTAKLAQLRDASPRPPTFEADVEKLMAQAETDQRAIEAALKRREFIKFCMWEEVRWAWRSTSRLSRVLQDYAADEAAFGRRIHQQWTALAEALGGVPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B522</accession>
    <name>A0A2S5B522_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B522"/>
    <dbReference type="STRING" id="741276.A0A2S5B522"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="286" mass="31667" checksum="D2A8E691FAF99408" modified="2018-07-18" version="1">MANVYDFYKPNLSSEYPAVDGPLTQTCYPNALEQSYDAFRAKESKRLGNKQGDKSAVTLSDFDYACFHSPYGKLVQKGYARLMYNDYLSNPSAERFSSVPAHILDLERSSTLLNKEVEKTFVGLSSADFKAKVGPSTLTSRKLGNMYSASLYGALASLLDTAEPSALQGKRIAMYSYGSGLAASFFSIAVKGDTTEIHDRLKLNEQLEANQVRPCEEFVAALKLREEKHDATDYTPSGKVEDIRKGAYYLHHLDSKHRRVYKIRGQEGEQDIVANGAPANGTQQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5N3</accession>
    <name>A0A2S5B5N3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">BMF94_4899</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000059">
        <property type="protein sequence ID" value="POY72092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5N3"/>
    <dbReference type="STRING" id="741276.A0A2S5B5N3"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="304" mass="33268" checksum="50E7CB90AFB36326" modified="2018-07-18" version="1">MSVNLLNLQWRAPEFLLACPTGTLASRSLALEYFSLSPFFDKASSNAQLRMQMMFSRGGMDGVDEEAELARFTGIEFVIAHAQPPDLFILHKRRRTSPTETTVVGAYHILNGNVYQAPSLFEVLNQRLLTSVHALETSFAALTAIKPTWTPERQYTWDVKSPPVASLAGAAANAEQVDSTETTGGVDGFGVDSASVLLDASVPGTLREPQSVALDESGSTADPIALDVKPGRGGDGDPPSRPDQQERPADAFNPLLFRALQSVAQRTEQEAIRDYERERQQEEQHQERELRDKREASSVAPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5U2</accession>
    <name>A0A2S5B5U2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5U2"/>
    <dbReference type="STRING" id="741276.A0A2S5B5U2"/>
    <dbReference type="OrthoDB" id="2529404at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="957" mass="98922" checksum="DD2E9CF54D317F57" modified="2018-07-18" version="1">MSGLEPFDFNKLWDVPPAHSAGFPTYANDGQMTSNATLPNSSAGESTSTNAYSPHDKAQQQQQQPPQWPQLDATTQAWLAAQQIHHNNASSIGLPASTASAQVQALRAIVGQGVQQPFLAGGGSGGQGGQGPQPSLPMPSLSLSGLNPAGHQAALQALLSGAAAGKLNDAALAAAFAAAGGAPSSQATTTDQATLAATRPLANSQDSQSTQSPAPGSISIPTPTLSTSQPSNNPQPPQRQHNQSPFTNISADTYANLIQQANSTLYGSQGQQKQQQQQGPANADNPQLLPASSSAADAATAAKYLPIHLDLRGSAMSLPTYGTGVNNGGVAAAAASPALPQYAFTAEDVVRHHQQHNLFATTGQAQQPAAQTNGHEQQRASSHGRTGPAGQGGANDGGLNLNEGGQNANAASVPSGSAAGGTFAFASAPQASGSNEANIVVADAVPKVESGNAGTAATSSSTDDAKVEGYSPDDPYIPALGRGARRSSGTGRPRVSYKEHLDTSSGDSDNSADSDFADEDDIGAGGSSKSRRTSTGGGGRGRGRPRKSSNAGALGFAAPKPAVGNGMTLTGLPPPFIPGSHAAGGVLLEAGEDEQMYDPALLGEASTSNGAGGHGGNKSSSKTRKRTSPDSTPGAIDPVTGFPRRTTEIPAVEDDPTIRPYGCNWCFTERREIERFARRQRRAMGLMDPKGKGRAMDQLPSLTGPSAVGLDALPILTGAGFGGGGVEQNGAGHQPDQDDYDSEEERQLSAAAIDPNLPPIQWRTVKELREHMSKEHKDRPLKAKKDDKEEGGLGYLGDGSGLLPSLNGGGGEADLPTPGAGTASTPDDRILSPADMPFRCALVPCDKTFKSLAGLRFHFQNASTNGHFVVQVDLDPETGEERATKRFKVDAKPSGRELKCPIPRCPKRFKQAAGLAYHLSHTPNHPVTEAMLEGFESTLLSKTKWWFNKQGLTFAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5V8</accession>
    <name>A0A2S5B5V8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5V8"/>
    <dbReference type="STRING" id="741276.A0A2S5B5V8"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="374" mass="39087" checksum="ED84B2D81EE8706C" modified="2018-07-18" version="1">MLVLGSAAMAGSGLAFVFSRNYTVLLLAATFGVISPSGNEVGPCSSLETAMLSQLTPSADRVFCLMYYQLLGFVGLAFGSLAAGQVISHLQSRTSTYLAYRSIFAVYAVLGLVKVLLCAFLTEETELWKSPRRSSTDSGSSVDGERQPLLSARPPIPSSVPTPHLKVPVVAVNEAPADEPQLAPASPSRLSLCLAVALFGIDAFASSLTPTSYIALFLQKLHHAPVSVISTVFAGGALCAVLFSLGTGALVKRIGLVLAMVTTHIPAQVITGAIAFAPTLPGAISLIIARTSLSSMDSSIRGALLASMVPPEARTRLLGIVDVTRTLAATPGPFVTGRLVEIHALKWTFVIGGGIKILCDSALLVGFRRAKLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5Y4</accession>
    <name>A0A2S5B5Y4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5Y4"/>
    <dbReference type="STRING" id="741276.A0A2S5B5Y4"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="185"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="456" mass="49139" checksum="366208D09B24FA0C" modified="2018-07-18" version="1">MVSAHEYDEAVQRYIRDIEDDLRKVSMSIHDRPEVGWEEYHAHKVLTDFMDKQDGFKVTRHAYDLETAWSAVFTSSAAENAKQVPTIGFNSEMDALKGLGHACGHNLIAIAGCASAVATARALEEFSLPGRVILLGTPAEEGGGGKAIMLERDAYKGMDACLMLHPGGGQDGKHGAGVITSNCISGIKATFHGVSSHAGATPELAVNALDAAFVAYSAISALRQQLAPGTKVHGIITGSDEWSPNEPIVIPSKATMLYGLRTESSFTLADLIPRVLRCFEGAATATGCSLELEREHLYLELRQSGPLAKEFAAAAARCWHSDDGESYHVEMHAKTGASTDFGNVSYHVPALHPMFNLPEAGPKDQPHAASYAKTTALPSSHEATLRASTALALTALKVLTSKDLRDEMYKAWKEDLKAIDAEHAIERLHKVLPEKQGARGKSSDHDHEDGHFGCQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6A9</accession>
    <name>A0A2S5B6A9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6A9"/>
    <dbReference type="STRING" id="741276.A0A2S5B6A9"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19508">
        <property type="entry name" value="RecA-like_Pch2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000680">
        <property type="entry name" value="pachytene checkpoint protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="298"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="571" mass="63142" checksum="8658FA05FB113CCF" modified="2018-07-18" version="1">MPVLEFAPPAPPAVHSSPVKPVARLQSTNFSRNALSSPLSSPAGKDATFKRSSHLGGEARAPGEAQEDDVSMEMALSQETDRRLSLRGGAAERCPDETGREPLTEVRLNGNGVEETAVHPLADEDAQSRNDQDDESVDERAPLHVEVRLQPTSTMRYDVLRNLISKHLHAEYDGLRTHAEVHDWRDVEVLAQHVDRIWIGECAIPGSAVNMEDVSLVIHLYQPPSSSRLTEFSTSPLADEDGDSDVPAASVLELPSLDLEGVWDSLIYDGEIKEKLLNYIYSTMLFSDALVDFNIVTWNRVVLLHGPPGTGKTSLCRALAQKLAIRLSDRYQHGKLVEINSHSLFSKWFSESGKLVQRLFAQVTELVEEEGSFVVVLIDEVESLTAARAGAMSGKEPSDALRVVNALLTQLDKLKHRKNCLVMTTSNLSEAIDNAFIDRADIKQYIGLPPTAAVYWILKTCLEEIMRAELVPTIELEDCETVEIYRSAGSSAAAVQGDRKIKCSLMLYELAEQCQGLSGRSLRRLPVLAHARHIGSHFAFGPKPKLEVWINAMRRCVEEEGKEMDRVRGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6M0</accession>
    <name>A0A2S5B6M0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000049">
        <property type="protein sequence ID" value="POY72406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6M0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6M0"/>
    <dbReference type="OrthoDB" id="2529991at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="772" mass="78289" checksum="F0C6D876A3916F83" modified="2018-07-18" version="1">MPLDLSHPRHLVPAAQRSPASTTTGRHGKRAVHLKLTEDVLRQLLDVVAPSTKPAGEQKFAVARGQIMVNVDGPQPVLVVGGISHPLSVVPEAADTTLVRLSSASRDLVPVANISHRATVQHRPADLDKAGQRARENREQVERAKEARKAVLLDEPPRLGNGSNSSKKRSASNPRPRQLGAAAAASASASSTPHPLSAPSSRLASPAIPASPSLAAPPPSTTSAVRHPSRLTAVPQTAASTVSVPSAAGPVAASGASSSRPPVGPSGTFRIGKGAVPASLSRSGSASSSASSSSSSSSSSGGSAIPLAAATASQQPNGHTDSKPTGSSGSTLSAAVARDGGEGVKAVVGPSVDSDPDSVRMEVDAPPTQPPPPPLPPVTSSSGPALESAAAAAAAAAEPRLTKLDANGSASGTTGGGKPIRPGGGGLMKGKESLKKDRRREERQRDKSALPAPVAANAAAVASKADSSTGGATTAKATPALPKGVNANKIKSEAFVNDSNEDLSEMDADGEADADGEVDDDDVVSQVSPSTAAVAPTKPAEPKSSPPLLKADERDSPPERKKRRLDEPAPKLVRKTSVSSKVAAAASSPKVTDKPLKRSAVVESATGAAAAATGSKDSGSEATITAGARPKKRKKEAVKRWYSSSSEDDDADDTADRDRAVKNNKKNGGTLNGMRTEVPATTVSPAKVSTADLPAAGPRAAARMSYLEAYAAYAGLYARLAAERASLEQGNAGPLLKDDGGPGRVQRMIDELSEKRRALEALHSSSTRPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6X5</accession>
    <name>A0A2S5B6X5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4343</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6X5"/>
    <dbReference type="STRING" id="741276.A0A2S5B6X5"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="782"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="864"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="906"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="916" mass="96856" checksum="2AE412D13AAC0012" modified="2018-07-18" version="1">MEQPIASTSATRLDTPPAHADDSGRGTPIDGSMLADKADEPETEPIPSLASLLLSTAESLAARSRNAPAVSAPDRPKKLLGVGAGSSGPGKASSPAAAFTLSTSPDALLSHPAAPPYLASLLAQPLSEIEALPASLANLSTTLDQDLSSLAYTRYSAFLQSHAAAQSISTLFTSLSDSLSALLDSTLSLEQAATAFGSKIDSVRDKRERMARVRDRIAEVEELLDAPSVVDACVRAGYWSEAIDVASRLENLHKRLLANSGTGFDSTRSSEDGFVEGQGARALLDRIRGEVNLALLSLRTRVLESLVQRSLKLPSAVRAIGVLRRISERGLAADHRKKSGDGPKTFSEGRRVELDEDALRVVFLVARWKCLRNELGGVEAQMTAAGIQLGKDGDAHVIAAKQDLQVSAEENDERARWTKRWIEVWREIVGETITTYAEVFLGSSAPLKAASDGNADQKVRAHALSPTAPLHLFLSTALDLLSNILVRAIAGLNAASALSSIVTQLTYCSHSFARYGLDFRQMIQLRERVELRIGRIVALEWEAAGRKWEKEWRDAWGHSGGAIMTAAKARRNGRVPLTDWLVVPEGLSTALSTPVPPAPTSYTKPAEAWHHQPSPSIALFPPLARFLNAQATALNSLRLLPPVALYTPLRRAQAVELDRATQVLSAFTDAWLAAIASTPLVDSTGFDTATPTVNGAECGVTTEDQVIAREREAERKAVAAAIAWFGRSVVPWCAAALESGVYAELVQSGRVGDAGLADGVKEARRRCEQLIAKIEGRDYAEPTSAAKAVSSESADLSDDAKAKLRSPPPIVTELPVIDPEAAVSAAPSSLATPTSSLAPDSALNGVTSKPADFLVSPLDGNDGEDFAIPDVAVSGAGDEADAPYVVPDKAPPPPVAAGVSPSLPSQSDTATASEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7K2</accession>
    <name>A0A2S5B7K2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7K2"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="47501" checksum="48CDCD395DB1C313" modified="2018-07-18" version="1">MPGRQATSRSSERRSGIGTDNTSIPVGSSMLPACDSTSRLTPTIRRCSLESRLSSRLRRKFALFTSVLTHTILYHGAEFLQQAKSRDNRDDDVHMRLIRNYKQVPDWWYGAFLVVALATSVGTIAISKADMPIWSLLLIVAYTAIVFTPIAIIYATLSYTISFNMIVELAAGYIMPGRPLANMLFKLYALGIPYSGTYFLEGMKLAHYQKLPPKIVFGVQLFSTLLAALVQVATKRWLVATIPDLCATDQPAGLSCPNVHGYTAASTIWGLIGPAHLFGTGKMYHSVLYWMIPGAVLPCATWYLRRRYTTSWLASLNVPAALIGSIYIPPLTGINYSSAFVVGFIFQYFLRRRRPEWWSKYNYLLSGGLDAGTSICGVVIFLTLLLPKNGQLTLDWWGNTVYMKTADWLGTPFKTPPPEGFGPTTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7W3</accession>
    <name>A0A2S5B7W3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7W3"/>
    <dbReference type="STRING" id="741276.A0A2S5B7W3"/>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="101"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="524" mass="56630" checksum="24915B79B847295B" modified="2018-07-18" version="1">MAAAKKSSPSSPARDDDHKPTTTSPSPSLTKKQQLHAKQLRQTPFPQWQHPTPEEAQQVCDLLASVHGMPERPKVLVDRPGMPAGCGNVPSVLDALVRTILSANTTSKNSTAAKVSMDEAYGRANYRAVLEGGAAKLEDVIRCGGLAQNKSKAIVAILERLEDRNINEMGLKPGEGELSLDWLHELTDEDAMMELISYDSVGIKTASCVLLFCLGRDSFAVDTHVWRISQSLGWLPPNGSVYSQEDPPKRIKQTTNPPSRDQTFYHLDYLLPNHLKYPLHSLLVRHGRGCVRCAANGVTTQDFVETCPIDHIVRRKKGKYTSPSKKKVVKTEDGETVGHVKEAPDGEENEGGDAKFEPLEDAPDGVVDSLGSKKGQGIKLEDASGMPHDPAVKEEEAAGNGPETPTKKRSRAAATTNGGAKRPRRSTRATRPVKDESESELSEADDASDSASSEYGGEQDQKPTRRATRAKASPTKTKATSTMKSSKPAAQKQPAAKKGKSAASVSRDEAEMGGQVYTMHGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7X2</accession>
    <name>A0A2S5B7X2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7X2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="110" mass="12702" checksum="4C8D3D57F36A723C" modified="2018-07-18" version="1">MLRYFSAPTVEARTGHKQLSDALQALQNRHVLAVLDLREDLERDYHLREWTDVYAATVARELQTLGRTAWSRKELDGPRMLDDLTKALEKVKDPLAGPHFRQDTTYPLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8A3</accession>
    <name>A0A2S5B8A3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8A3"/>
    <dbReference type="OrthoDB" id="2528996at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="280" mass="29935" checksum="FDB7CFFDFC48921F" modified="2018-07-18" version="1">MSSQSPEDDPTSSQLRDNDHDALVALLDNFIADNTKKRRLKLEGIVSHGEKLAKQYQGDVKKVLDDADAEIDKRIEAFQKEEALRIDETRQLESQLVALLQKRSDSVELAAGAVAQEIASYVEASQQLTKEIEAIADEEMAYWEKQKELLFSPPPPPPPSEHDVGGSVEAGHVPQQQQQQYGGPQGEAKNASPTAAGRFFPDDQFEYADPPAEAAPSRAAPARRPAAAGAADGERGSASKEQQNGGGEGVTFFVETEPTRGGGGGGGEAVPMQVDSRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8H0</accession>
    <name>A0A2S5B8H0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8H0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10654" checksum="2F8106201498430A" modified="2018-07-18" version="1">MPAMQISYSITRSDPHPSDPPASDSVSFPLDSSSPHAHLVSLETALGDARSTMNERLTEWKNVLKDVEKPPKKGKKQDDDEEVDDDDEEAEEDETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B914</accession>
    <name>A0A2S5B914_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B914"/>
    <dbReference type="STRING" id="741276.A0A2S5B914"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="720" mass="79232" checksum="B97C92F9113064AD" modified="2018-07-18" version="1">MSSTAMASNEKQSLLSLPVSSHAPIYHLPPDPLFPTPASLLRLAEYDAPPEFGQDGPVALKEGDPVPPSMLRRSRQIRRGGCFTYVSPLPIEFPYDIREEEDETRTNSAKPSTIETVLAEYEVSTQCPVRDAGTSAPASESTAFSSSVRDSSRFPRARLLSLNRTLADDWLPQLDLGQEGDQVRQQAIDVMAGKTVLAREPRSDAQDLPDKNGFAPWSLCYAGHQFGSFAGQLGDGRAISILSTPATPEVAAKTGFRAIELQLKGAGRTPYSRFADGLAVLRSSIREYLGAEAVAALGVPTSRALALVHLPDVKVRRERMENAAIVTRVAGSWIRIGSFEQQAYRGETDSLRALSYYVAREVFALGDVNSAGTAASRSLSLNVLREVARRNALMVAGWQSYGFCHGVINTDNVAINGSTIDYGPYAFMDIFDPSHICNHSDDLGRYKFSNQPTMVLFAVSKLGEALSELIGAEVELAEREADGAGFAEVSEGWAGEGEGSDDMERWRERGLQEVEKVKNDFVQIFRDEYERLMRLRLGLTQGEDDDFQLVSRWLDLLAQSELDFTSSHRLLSQFSSTSDPSFERFLSAFLPASAPTNSRSDWTGWFESYEARLAREGEAACTGRRERMNAVNPRFCLRQWVLEETIRKCDREPDGPGGGIEQLERVLAMSLNPFEAYGEPDVAQGETGEGACPTKEEQERQRLCGIGSEELLGFQCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B987</accession>
    <name>A0A2S5B987_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B987"/>
    <dbReference type="STRING" id="741276.A0A2S5B987"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="433"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="561" mass="58664" checksum="F519AFE9BCE6DC50" modified="2018-07-18" version="1">MPPPQATYVARTSNSGYDPATLSDDEDDSASVSSSAWSALAANNTDSAIPTLAVLDGKIPPTSTNELDDWKVSRVGGEPSFPLSSPPPIDSRTCLTCSAPMPLVIQLYCPLPHSSLERVVYVFACPRPACQKRREPRSAGEGPGCVRAWRANGVWRDGEEALRREEEEKRKRDDEDRVKRERKDAASKIQLGGLVFGGAPSPIAVAGGGGAAFNPFATATPAAGGAFNPFAPAGPSTSAAAVNPFAPVAAAAPVTPPAANPFAPASMTAALDASAIGADQTKSAAPVAAAAEQIISTWPPIASSSTASPPVAAYAPQYVATLYEPASSKGDTKGKSREAELARAFEAELAIRSDSGISPTATASASKPSGRGTAVDDFEDDFDERRPGKGSGGRVKKGAERAAASKKPSSAQPGGGGGGVGEGYEIQRVKGVDDVFLRFQERVSREGRQIVRYDYNAQPLPYSSASTAYKLLHPPASANSDVGTFRPSQVPPCRYCRGPSAFELQLMPHLALGLDDQYAWATVWVFSCAGECTGGASGDSVEEGEAWREERVLVEWEDEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9E3</accession>
    <name>A0A2S5B9E3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNL-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9E3"/>
    <dbReference type="STRING" id="741276.A0A2S5B9E3"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="76"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="231" mass="24915" checksum="015FD78E5FA69F9A" modified="2018-07-18" version="1">MQSSVRSLARTIAVNATPRLRTAAIPSWSVLPSLPSSSRAFPPLGRSFATSCSRRDDAAATRVPVNAERGTPIGKVVDRRLRIVFTCTAPKSQDEPDSAAACGHRSSHEFSRSSYEKGVVIAQCPECSNRHLIADHLHWFSQTPSPAHPKGQTIGSEQPRTIEDLMREKGETVEWRTGATAENPEGVPVDGEGGRSAHEAIKLVVRERTEDDGGKTVEVVPESEVPLSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9G6</accession>
    <name>A0A2S5B9G6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Monothiol glutaredoxin-5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9G6"/>
    <dbReference type="STRING" id="741276.A0A2S5B9G6"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="7">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="162" mass="17712" checksum="4A0C208BD2CA00E3" modified="2018-07-18" version="1">MSSLTGLLRTVARPTAWSTQARAPLAVRSNWVRIASQHRHLSQEAKSKIDGVVQKHPLVLFMKGTPSMPQCGFSRAVCQILEVQGVSEDKIVAFNCLEDPELREGIKEYSSWPTIPQLYIGGEFIGGCDIALQMHQNGELEKLLVEKGLVEAEGTAEPGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9K5</accession>
    <name>A0A2S5B9K5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9K5"/>
    <dbReference type="OrthoDB" id="2528735at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="351" mass="36331" checksum="9D94CDF2EDFB5635" modified="2018-07-18" version="1">MSSGSVTISYTTIAEVALVAALVGGIAYIGSSKSANAPHPALAPQLAPSSTNKSAKGKKKKASSSSAQAQVQTAVVEPVVEVATAVKDHVVNAAKSVAQQPAVKQAVQQAQQVVQNVTEGVSTAASEPSKKKAASKKNKGGNKAAPAPELKPDATKYAEQKVKSEGALDADMVDPEVDSKPQVARVMKVVGGKAGAPQVNGGGAASDEGWERADAFDDDEGGWESVVSKKPSRPSTPSLANGSSAANDRVVPGMPAAALTKKQRENANKKAKEQSAKEQQNREQEDRLREYRREQEKAKLAADQAARARQRPKSQNFFGAEPVAPSGGSSKVLSGGMTASLDPSTGSLVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9X5</accession>
    <name>A0A2S5B9X5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9X5"/>
    <dbReference type="STRING" id="741276.A0A2S5B9X5"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="152" mass="17656" checksum="446BAFD4A6C1BE88" modified="2018-07-18" version="1">MNLRRATVDDLMGMQNCNLHNLPENYQMKYYMFHELTWPQVSFVAEDHKGRIVGYILAKMDEEPTEESHGHVTSISVLRNYRRLGLANKLMQLSQQAMRTTYNAAYVSLHVRQTNRAALGLYKDTLGFKVIKIEKGYYADGEDAYSMQLDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA41</accession>
    <name>A0A2S5BA41_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_3177</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA41"/>
    <dbReference type="STRING" id="741276.A0A2S5BA41"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="108"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="224"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="533"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="352"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="9">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY73642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="808" mass="87207" checksum="0AA64319AD3B4D18" modified="2018-07-18" version="1">MESAALEALDLPESQSQSQPWTQTQTQTQQTQASQGTAADSSRFPSHLWGILVAVTGPRTSSTGDVFAVPVNGRKPNGATLLSSSTTPETAALPRPERLELSRGQNEFVIGRHPKSDLRLNGPKISSVHARIWIDPDTGIIRLEDKGTNGTYVRNSKVGKGKVTVLESGDPIVFGPASTDFDQEFRYIFQCDPSLTSSRTADPYGLGELSQSQSADGTSIHSFYEVREQIGKGSFATVRKGVRRRDGLMVAIKIIQKARFMNNPKTMEMIAREIKIIQTLEHRFCVRCYDYFEDDQRIWLVLEYVDGGDLLDYVMKRRGLKESEVREISLMICEAVAYLHSRGITHRDLKPENLLLTRGEHPVCKVTDFGLAKMANDQTRLTTMCGTPTYLAPEVILNPDPKSGYSSIVDAWSIGVVLWCCLTNQTPFDETESDPLAVRMRTRYVDMSLPKSLGVSNVALDFLRKLLTPDPRLRMSCAQALRHPWLITKGSSDAESIASIPFMCSSLPYNDPMRSVIDSTSNAGEDAVMTAINSGTSPAQSDARMDAGSVAQQDSGVDSQGFGKLALSEIGNREGVSPTSPAADSGQTDRPSSQLAGQKRKEPMSAFSDSSLSSLATSQPLESSPAKMPPPPPPLRKPAPVPRQALLTEIVAETSEEAEPSTAEDDTTEQAAVVPASPTKDAELATATADIALDKPTETPPSVNDAETGAQIDETPSKTSEAAPTESSAPLEPPARRPRASRAAAAKRTSIASGSGARGGRRASAAPREQATPDVEEADAESDAAPAHVPTGIAATVKNRRRKAARYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA42</accession>
    <name>A0A2S5BA42_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA42"/>
    <dbReference type="STRING" id="741276.A0A2S5BA42"/>
    <dbReference type="OrthoDB" id="2371309at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="163" mass="18091" checksum="C38F6CEF4CFF5EAD" modified="2018-07-18" version="1">MALAALIAAYSLAGAICLFIYGGISIAIFLSSLLLIIAFTNYSVVWTSALQFVLSFISIVSIVRAGFMIFRLNGFQDNVVWECSHDRMLYNATVAADPTPLATYDPARVPAAVCSYGFHTVYLAFACALAIDCILQLYQLFMVWRFKTFLRQYWLLRSSPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA54</accession>
    <name>A0A2S5BA54_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA54"/>
    <dbReference type="STRING" id="741276.A0A2S5BA54"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="651" mass="73314" checksum="BC100E609893E2F9" modified="2018-07-18" version="1">MSIPGHYEPSSGSDLDSDSSFSPAVMNHLEAIAQLSDDDGDENDPDWSPDQGQLAMLAQDDEDDDELDLEETDDDADPGGTHQEQQEQQQQGDANEERGALQIGYDLLAIDDSLVRDRHADRERRPTRRTRKSYYPTVTEPQEAGVRLERGGAFGPTPNKYDTSVRRTWNYSPRSAPDYLRWRELDFRQPRKDVLGDMMLPNTAGVEVSQFTSKVYSGQYSSDGNFFYTACQDFRVYIYDTATPPRVGDKSVTDSSAAARSRHGYLHDWEHRSSLKLTKVVKASPQNCRWTLTDAELSADNEWLIYSSISPRAHMVKTGRGHSSWDSSGSHDDVDHEQEELNFEGGAGRYGGYGGFGIWSLRFSHDAREVVAGASDGQIFVYDVETRRTVLRVLAHQDDVNAVAFGSASDSNLLLSGSDDSFVKVWDRRSLDGEKPSGTCVGHTEGVTFVEPKGDGRYILSNGKDQAAKLFDLRMMMNDVDFDRLRLDRRSFGIDGWDYRQSYYAKPRYQKHPHDNSVMTYRGHAVLRTLIRCHFSPAATTNQRYIYSGSSDGKIHVWSLDGLVVGVLDRAESHPLINQQSGEYNDPSDYELRTTKRPSRRARGSTVRDVSWHPYEPMLMSTAWEEGRGSVAGSIALHEWAGRPRHEALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA76</accession>
    <name>A0A2S5BA76_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA76"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53636" checksum="B41B9B3E0030D812" modified="2018-07-18" version="1">MPPSCTVTEASVEASASVRFTWEFEANLDFAPGDVFKSQPQYSAPLDGEWFFRIRGLSQEPSTISFELEHGPLERGSLGDRVDVTMDLEWLDTAEGSAVPLWSFTLAPSSQPSGTSEGTSYGFGSVMELDPPEECPLDLYRSTRRFRFSISIDKDLEATPAGTHGTPFHDQSKALRLTANFHHDLCLHFPNARTRSTDLWVNSSMLSHTSPYFDGLLAAGWAETAETAETAASGPFEKDAGRPPTASRDSTLCADETIWDDSDDDTAVLSKERSVAGPSTHFRKVNVTEAAPATYSAVLLYLQSGYIAFAPLSSSSPATAAWESSDGSDEEIFGRLGRRACSTRGKWSCRAVGSYGINIRLRHCPSGPAGSSCILLGNEQLAHILQIRELQKLALARIYEELDVQNVLIELQSPVASAFDDVRRVITDFVVRNWTAVVQTLMWAQFHNKFINGEIEARLIYAGLIERFILLREPYHDQAPRLTQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAA1</accession>
    <name>A0A2S5BAA1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAA1"/>
    <dbReference type="STRING" id="741276.A0A2S5BAA1"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="44453" checksum="7DFD79BBD918F515" modified="2018-07-18" version="1">MKPLFFLAFAREEVELSDMPSSYRLYAGGYEGKIVQLEFDSDKAPADRLCVTGQFECGEAPTWLTFSQDGKTMWSADEWGKENGTLTTLHVGEEDGLWPCHSSLLTSTNPRQILTANYKGANVHCIQVGKDGELDARTAKVVSMDKTGSSLGPVGWRQEQAHPHGAHPDPTGAFVVVPDLGTDDLRILRVDTVSGAVSEDKIVHMQPGDGPRHVLFGLLRSKGVDGRKETRLYVMNELDNSLSVVGVTYPAAGSSSVLPDFKVLQQRVSLLPPRPFPHQQNFDSWHSAELVLSPCGHFLLASNRAEAHDPAAGTREGPDDLVAVLQIDSDGLLVEASRRLVSSGGRAPRHMSFSSESIRQPYKAGTPAYLAVAAHDSDEVIIFEFSSQGALTEVARIRDVGRPGIVLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAD1</accession>
    <name>A0A2S5BAD1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAD1"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="555" mass="59513" checksum="D0218AF44BC3366A" modified="2018-07-18" version="1">MSVVKKLSTNDSAQGEREPLLGGGSQRVDDDAVEAVEVKARTPLPLKQTLVLCLMRFAEPVAFSIIFPFINRFIEDLHVTDDPSRIGYYAGIIESLFAFTTFSTVLAWGRLSDRIGRKPVLVIGLSGVTLSIVSFGLSKSFWMLVVSRCFGGALNGNVAVIKSVLGEITDESNQARAFSFLPLAWSLGSVIGPLLGGYLSHPVEQFPSIFGHSEFFRANPYALPCFIGALFPFCGAVLGIFFLEETLKPARSTSADDTVGAIASATPAAPGGVVNKRHQRFVAATSTTLPAPAEQLRRLEEESDGPDSGYSTPRTLASTSRDPSPVKGKLTPRAPPNFMSMFTPRVKAALGVYSMLALITVALDALLVLFCYSPVKIGGLGFKEADIGIALSISGLSSVTFQILLFPPLQLRIGTVRLYRALMSLWPVVYMLFPVMSWCAKEKGRRAVWGVLVCFLVLKAVANMAYACNMIAITDSAPSKRLLGSLNGVAQMCSSLMRSVGPFGASSLFAFSVSRHVLGGQLVFYIMVVLAILGAASTWALHEGGRASAAEDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAM0</accession>
    <name>A0A2S5BAM0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_3355</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAM0"/>
    <dbReference type="STRING" id="741276.A0A2S5BAM0"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="70"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="218"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY73814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="300" mass="33951" checksum="F2E7E66ACC051930" modified="2018-07-18" version="1">MVRSTIIARATDGLPLAASNDDDEQPSEQGSTSGQRFRGMDTRGTGGAIETRRGPGSGRRNRSSRKERLYVAPVSTETRLTTRSAALNNDRFEVAKLPEYKQQAKLIFRRLTPQSEPRCSIESGQCTLHYLISDSIVYLVIADKSYPRKLAFSYLSELSTEFARSYPPETSLKPGLRPYAFVKFDTFIQRTKRLYLDPRGAEASGLADGNKSGPAGNGLDRLNEDLQDVTRIMTKNMEDLLWRGDSLDRMSHMSSSLRDESLKYRKAARKINIDAMIRKYAPIVGIGMFVFVFIYYRFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAR8</accession>
    <name>A0A2S5BAR8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Purine-cytosine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAR8"/>
    <dbReference type="STRING" id="741276.A0A2S5BAR8"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="60764" checksum="0B98A2BA9477C015" modified="2018-07-18" version="1">MSTDIRTTPLPAASPSVLSEVALDEEKALSLDSDTKGEADVSSAPSSKDDLDGIVAAHGAFARVTRYLAQLGVETRSTERIPEDEREQLSLTRLIVRQIMFWFSVNLSFSCLGTGMLGGMYFTLDFPTSMAVIWLGTALGVCVSATMATIGPKTGLRTMAASRFAGGWPGTAIFSLLNAMTQLMYAVTTVIVGAQALRSINQSLSLVVGIVILTVVVMVLCIWGFQFLHFWERYAWIGCFIIYCIVLGLGTRGNYDIHAGTADMATGRELQGNVLSFLGIMFSVGSGWTSIAADYNMTLPHTTPSWAIWVSSFVGMYLPIAFTCSVSATFNILTDPAYVQAFEEESLGGVVGHILISGAGGFGKFLMVLLAFSTVSANIPNTYSGALCLQTIHPWLMKIPRVFFVIVFAVVYLVVALVGREHFSEILSNFSAILAYYVSRSSEAQEASAPQNLPLRATAFLSAIIFIEVFWFRRKNGPLADKTNWDDATDFSKLPPGLACVGAIVCSIPLIVLSMAETWYTGPIALAVSKPYGGDLGFEVAAGMSAISYFAFRTLEIKYFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAV5</accession>
    <name>A0A2S5BAV5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAV5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="290" mass="32759" checksum="9DB7DAA686073501" modified="2018-07-18" version="1">MPPVRNVRSSQSKRIGLATASGGQQEVQHQATTPRWTQSAALSHNIGDAPISPYLVWAAQNRLVPPLALLTEDALEALATDSALWTTHYEFDDLEGRDAPRRRCSNANCFDAWLPWTWADEALQFETFMSAFAKLVLLVRETLCTDAGARAAVQADTDQFIRQVSMRLRRPGNWRFIRRPVIDAVGTWRQQISRGVPWHENLLAQIGSDQIDEGLRCVTMHGREWPLSDHKPHGDTWPEIVESVLGFWRDKCECRQEGTRSATSIPMMNSDVPKRLLTIKLAETTKFAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAW8</accession>
    <name>A0A2S5BAW8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000032">
        <property type="protein sequence ID" value="POY73925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAW8"/>
    <dbReference type="STRING" id="741276.A0A2S5BAW8"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45255">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45255:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="44"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="9">
        <location>
            <begin position="135"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="200" mass="21967" checksum="511FAFF86116632B" modified="2018-07-18" version="1">MPAEISHRPLPQAASTLPLRQSHPPFTLDGGAGPAQRHPCEHVDLYARLGLAASPPPSAADIRLAYRALILQAHPDRAAATTTSGATVQDQLAGDVDAREVNEAWEVLADEESRAAYDAARRAYLSRTRAINTAFAVSHSLDDFEPHFIDDDDEPAYYTHPCRCSSEFRITVDQLEHGVEIVTCDGCSERCRVEYEVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB03</accession>
    <name>A0A2S5BB03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000031">
        <property type="protein sequence ID" value="POY73962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB03"/>
    <dbReference type="STRING" id="741276.A0A2S5BB03"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015429939" evidence="1">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="246" mass="27163" checksum="940EF86CB3AA5173" modified="2018-07-18" version="1" fragment="single">MLPNSGQRPTAAALAALVVVRHVAAAALDSPGAATARPDATLPPNLDHWLALALEYTLEGNEAPQSLKLWLERARGDGEDAVLNQVDEFEQTLRQLHAGGMDAALDWIVDEFKPLIAWSDDDELTILSQPPPLLRSSPLGLFVRRNYLTLSRMELDELQTWWRDFERFVDGEKRGKQRAVDLGDEAAAAASRAYSKARAQQDYHSAREIVRTFPVLGAGPLDNSQEALLHLALLEYEDGGYIAARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB67</accession>
    <name>A0A2S5BB67_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB67"/>
    <dbReference type="STRING" id="741276.A0A2S5BB67"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="50371" checksum="CF5D3036C1B38066" modified="2018-07-18" version="1">MSTQQRSRPLGALEHCLLSLMNVGVPSTVALAAVVRSEKSPLHARLPAAIATLLNRYPLLRCRIVNAKTDAPYWHEDDSSEPAQLIGVEEAFSKGADTCKVLHEALALANELDGTSLPTWRVWLADAPVHGQTRVVLGVSHVVTDGSGARDLMADLLFLLRDDTGPSETATALAQQELPPSLETVMERLPAVAGPSAAPEGTESSTSDPLFLKTPVSPPHLQPTAVRLVKLPASTVVALKRQAKANGVATLHAVLYITALVALQKNSGSAPVAIKGTTPVSARALESQLPRATGNYVYEVNSTHDDAARALQFWEACAAYARRLNNSATRERGLEEMRQLADVPNVVAREALSNPLKHSAFDRWRLAQLAQVESFQTTFEVSNLGVTPPTGWENDDGLLELVWAQSAMLRTAFAFNPISTRRGDFSLSLTFRDGTLAQGLADTIAHDYERILRSIAAGAIGSSTTCVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC23</accession>
    <name>A0A2S5BC23_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC23"/>
    <dbReference type="STRING" id="741276.A0A2S5BC23"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="115" mass="13413" checksum="ED46FF9345786365" modified="2018-07-18" version="1">MMVDLEQKKADIDKYEEAIYYSPRYSGKSLAFKGRVLVADSAPPLDDGYEYRHVVLPKALVKYLPKDRVAEEDEWRGLGIRQSPGWWNYERHAPEPHILLFKRVKEPEPAGQKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC42</accession>
    <name>A0A2S5BC42_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_2539</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC42"/>
    <dbReference type="STRING" id="741276.A0A2S5BC42"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="826"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY74345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1004" mass="108857" checksum="F663207C92FD055C" modified="2018-07-18" version="1">MATLPHTKTADQLAQEFHVNLESGLSLQQAAQHQEQYGKNVLPDEPSPPLWQLILEQFKDQLVLILLASAGISLVLAYFEEGDDKATAYVEPIVILAILIANAWVGVAQETNAEKAIEALMEYSPDEAKVLRDGRAQKVHAVELVPGDVITLAVGDKVPADSRVISISSASFTVDQALLTGESYSVSKSTGVVEDEQAVKQDMTNMLFSGTTVVTGKAQALVVATGTQTAIGDIHTSITSQISEKTPLKQKVDDFGEQLAKVIAVICVLVWVVNFRNFNDPSHGGLVKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTKKMAKKNAIVRSLPSVETLGSTNVICSDKTGTLTTNQMSVSRFALPTSAGLNEFQVEGTTYAPTGHILAADGSRVPPASLANPTIIRLAQIASLCNDAKVAYSAENDTYTSIGEPTEAALRVLVEKIGTAESAATLSGLSAQQRVNAVNLDIESRFSRLLTFEFSRDRKSMSVLVREKAASTAALFVKGAPETVLERCEYIMVDGKKQPLTAQLRSDVGETVLTYGSRGLRTLALAYVEDVDPEADHYHTDSSAEYVRFEQKMIFAGLVGMLDPPRPEVRGAIAKCKTAGVRVVVITGDNKNTAETICRQIGVFEEDEDLKGKSFTGKEFDQLSQPDKVKAVLNASLFSRTEPGHKLQIVELLQEQGLVCAMTGDGVNDAPALRRAAIGIAMGSGTDVAKLASDMVLADDNFASIESAIEEGRSIYENTKQFIRYLISSNIGEVVSIFLTVLLGMPEALLSVQLLWVNLVTDGLPATALGFNPPDHSIMRRPPRSAKEPLISGWLFVRYLVIGTYVGCATVFGYAIGNADAWWFMLYEGGPQISWYQLTHFHSCSEKFSFIGCDMFTNEMAKRATTVSLSILVVIEMFNALNSLAENESLLTLPPWTNPYLVGAICLSMALHFMILYVPFFSTLFQIVPLNWQEWKAVVAISFPVILIDEVLKWITTTFIAPPSKQTVKRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC45</accession>
    <name>A0A2S5BC45_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DSC E3 ubiquitin ligase complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC45"/>
    <dbReference type="STRING" id="741276.A0A2S5BC45"/>
    <dbReference type="OrthoDB" id="2556122at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 C-terminal" evidence="3">
        <location>
            <begin position="285"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="429" mass="46151" checksum="4F9EB12631433668" modified="2018-07-18" version="1">MASSSRYEPLSSYPPLPTPVSRSDKGKGRATRDDDESTSTDDGDQGLSVGVRFTDGQTQDLVDLWVGARESVRDLKRRIRILRKNTLITRAEPGDDGTADERIERPRRLRLILLGRVLPDGVYVVPFTNQLLSRSQPLSAQPNARGSLDSDEEEEDDDDDGNQDQDPVTAGRKSLSATGRGILGSVITSGVSFARGRTSLEGDRVGELDALEKGKGKARAGQPGGRGKRRRGGGGRGGAEPPTVWLHCSVGDPMGEDEIQAEADAAGTGTSTASLPSQPQVTPLQGFDRLREAGFSEQDVENLRSEFRANAPAPSSDRDAAADEEHQRALEEQWMSGMTGLEEAAGGGTSGEGNAACDTSALRLLSGRADPKTVLIRTNSGGHYYSLLKGVCAGFFVPFLPLFFFRTQIFSKRCLFFLLDAFGFLRMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCK2</accession>
    <name>A0A2S5BCK2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bud emergence protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCK2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCK2"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="187"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="368"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="71091" checksum="30EE428A138AB8E2" modified="2018-07-18" version="1">MKGIRRSLNKDRIGAPAGATKNGVVLQAANSPRPQAPPAPPKAVIRAIAAYQAGGPQELSFENGDFFHVVSDEGGEEWFDASNPMTGKRGLVPADHFQVLGRNARETSMQGRQAKKLSSGSANSVGVASHGGAAAGPAAGSSWKPGQPVASGIRLPAGGAASNPTASGSVANAGTAGRPRSGQGARNQPLYGVVQYDFVAERPDELDAKRGEPIIVIAQSNHEWFVAKPIGRLGGPGLIPVAFVQIQDMATGKPVENVEELIRSAVVPKVEEWKKMTADYKQASIPLGRFDFAQPAAPAAASSSLSSPTSASGPLSPPPLSATSSQYSQQQQQQQYTNGYSHPYANSQSQTTESGGYDQRYSYTRERQQFGLVTSASVESFHQEEGSFWFHLRAFFSTGASLILYRLYQDFYDFQIALMDDFPVEAGRVPGDDGQTERILPMMPGPTEYEDEVVCAQRVHDLSIYLADLCTLPERIRGCGLMYEFLVPRAGDVVIADGAGDGDGGASAHGGAVDNQYGELVQYLDQMDGAGDVGSPQSGVNEVAGQFGHMSLNGQADGGYGAVMAGQHHGEDPANGRPPMGNANMDAPFIKIKIFHRNTDDLIAIRVPPTVTHAALLDKVRERLGREVDHLQYREEGAAGARLIGLEDDDELERWVRSGAKLVLYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCY4</accession>
    <name>A0A2S5BCY4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="8918678at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:Golgi organization"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
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    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="10">
        <location>
            <begin position="1814"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="9">
        <location>
            <begin position="2020"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="620"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="699"/>
            <end position="721"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="1794"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2111"/>
            <end position="2133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2395"/>
            <end position="2449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2465"/>
            <end position="2797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="620"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="658"/>
            <end position="669"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="699"/>
            <end position="712"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="751"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="919"/>
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            <begin position="982"/>
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            <begin position="1024"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="1061"/>
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            <begin position="1083"/>
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            <begin position="1100"/>
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            <begin position="1162"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2797" mass="298211" checksum="1F62B9007A3F9B31" modified="2018-07-18" version="1">MTVQWSAWPGYRVGHRWSRGSVDDDVAGFERYSRPLGLLESGFDVGAQRQGQSDIHALLCVDLEPSPSTSEADDEAPRLNWSNRFLERVWHSWARLRVRHPLLAARIRTGGQETIPGVAAREYVHDEPISDASALAAAHPTVLLHEFQSDEHTLEQACEQLLDDHVLNGERTLLDQGECLARLILVRDPIDPLKLGLALNVAHVACDALSAFRILRDLFSDVTASPLEATPHCPTKLRSLADHLARAPCSPPELAISPCAPRTTAEPSLPLANEEHYPVVPLGQPPELAGPSLAQRRWFWAFKRIILLRRQDAYPRTLPFPRKVLGIDPAAPPQPRTWWPRLRFDRETSAVLFAQCKKEGVSPSMLLYAMTTLALGPILAREHPTKPYHPIVIGFPFSSRPFSTPAIPSPHADAGTAPSDPLSDVALRITFSQIQLPHISLLDTDEPAQSRRLRAQAFCSARLAKAQFAKMLAPDPLPRSLFHAEGYGRILDRLLNMGGANPISYKRIPTTLNASMIGDVDRLLPTSFHSRTASDSAGTAPDGGESGTSPGDFCLVLHDLRFGTRLHRGEGMLMEAFTWDGMLTVCLGVDDELIWSEDVDALLYGIQKMSGYGGASYGRGPPLQQYAQQQQQYAPPQQQHQQGAYGGQYQAAPHDPYGTSQYGGAQPEQQQPFETLYEQEELISPEMNRGYGQQQQYDAYGGQQAGDGSAQDPSQQQGFEAPYYPGWVYDAATNQYLPDPDYQGEPDAEQDGQQANGDDQYGQQQQQQQQQHDAHFDQSNDQYGYGAPSADPYGQGGAEPKQEEAASAPNDAAFEPPHYPGWLYDSATNSYVPDPNYQGEGVEEDGQGGQESQEGDGYGANGNPAYGGDRANDAYAQPAEDPYAADSNPYAADSDPYANEQGQADPYAQPESHDPYGQAQRQQQDPYANSEYDANQDQYAGYGQQNETDAYGEQRHDGYGQSAPEPYAQQDGQHAEDQGHFAAQQASYDPYAPAPPASQAGSARTGPASPTLSQNGYAPGPAEQQYTSFAAAYDQSSPQDQYTNQAHDPYAPNQQRQQQQEAPASSKQPQQVPLPQIREPSRQRATSDAYATSSEANDDPYAPRAARSPTARRPTVSRPAVALSPNLSASPALNAIDPTPESLPLAAAPPRSDTASGGALMAPPPPRASPAPAGPPPKTGQAAASAAVSAPPRSTASVAASSPRSDTGPGFASPPMRAAQPPASGGQQQSRQPPAAQASAGAAFDIPPLRQSATGRSAAPAPKDGRNSAPAPYAPEQEPPRRNVAADAYAPPPASRPAREAYAPASQPAQAVQPPQQRKSAAGGLQPPARRAPHQRGASAFAGDSPYGAPPQGPPTSMYEPPQAVEEIKEEDEDEEMPQQNEQEPERPEEYMPSWMQATVTAPPPQATPYSPPQQAQARPRPNSRPRFDAPISPQIEQEPPKRSLRAPAKLDAGDDLAAGMQGMSLAGRKSPADPPPPRAGGQAPPPRATGQAPPPRAQPSTTQPPPRGGPMPPRSTGGAQRGNQPPPPRGGPLSPREEAPSFEQQQQQQQYYAPPMPQQSQRRAQPGTPDRGAVPQLNFEAPSPVEHPASSDRGDRYGYNGNGRTTPVPMAGIEETPEPQDPEQDDYFGGASSSANRTDSAAGSQYAPATENGQMTGPTTPSSHYGGDWRADSQQRGGYDYIKQEHKQYGAPADPYAPSASSASRSEEAYAPREYPSREDSRTPSAPAPPQTAYASPPSRNVAQQALNARRPAPPSQQQQRMPAAESYSPYAPGQASLPPSGGKPYDPYAASSSASAASSQPAADLGLERCAAPVVTFGFGGRMLLVFPRGRQPSYGIDGANPYGAPSQHEQASNPSTVHIRRLDEIVPQAGEGSTFPGPVFLDGGKANSSKKRKEALNWLSQRVGELEQDLAYVRGAPSTGFGSEHAAERKAQVEARLLLVKLLRVMLENEGKIVGSPQIDDVVRAILNPDATTDTGNATSLPTADQLAAAASTRSEPSASPFVTYGVSGSDLDEMTSRLLRGDRREAVQYAVEHSMWAHAFIIASCVDTDCWKDVTNEFLRAELMPSSDHTGPGAEGREALRVAYGMFAGLGDESIQQLIPPQSVAPGDVSAGFSSSMSRSASQNGPVSPMSKEALEKWQETVGMIVANRTAGDSAALTSLGDALLANGRIDAAHVCYLLSPQMAFAGGMGMPSSRIILLGSIPFATGSSIDLESVKLTEMLEYALSLVPVLKGHEPFVGLPHLQAFRLYHAATLADAGDVSRAHKYTEAIVNTLKLATKPTPFYHPRLVAQIKTLTERLGAAPGQKETGSWLTRKVPRPTVNSLWSTFEGGFNKFVAGEGEPSPQQLAAKADVAQQANGAAVGAFSHFSSIAPDSTGGLLSRTQSSSELASSDYLHPSLPVRPSSATRPTSPLAAPASSPLGPNPHHQQSPGPPPVKRASFKTHHARSSSLGAFAGYDYSPVAPPPWQSYTPPSLPGRGRNGEGQDSQPTSPRGQPTSPRGPPSSRRPQFAAVEERLQEDESGFISPMAHLTPSVSPSPASGRQNMDQAQTHRRMTTAEELADLGIGNSKSKKPAFDTLEEELEAEEGGMPPPPKKPESGPSLGGGGDASASQGQQGGKLDEKPTIKPSKSWLGGWFKREASPAANGPGPVRANLGESSGFHYDKNLGRWVNKAGKGPDEASSPVIPPPRASTASPSRAMRAEPARFSSEAPPPVPPMPTRSQTGPMPPLSRSATTSDLRGDARPPSAASNPTRPPSATGLPPRMGGAGTPTEGLSRPSSTRGKKPKYVVVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD37</accession>
    <name>A0A2S5BD37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD37"/>
    <dbReference type="STRING" id="741276.A0A2S5BD37"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="309" mass="33752" checksum="F07105217558FA64" modified="2018-07-18" version="1">MPRQIAFTTVDAFSSTPFGGNPAAVIIWPDAALAQDDALAQNIAAEFNLSETAFGLKLEGGTDKQPRYELRWRTPTREVNLCGHATLATAHTLFTSHHPDAESIAFQSRSSGTLIARRIPDASGRTERIALDFPVSPLVTLEDGHRRRPKILETVAEAIRDFDPSRVLRVAWSDVREAAIVELEAGVDLEKLSVDPTPLPQLGRQLILTCPAPAESGSDIYSRVFAPASGVPEDPVTGAAHTALAPFWLLDKHSISRLPDPTRAHDTSVLRAKQVSRRGGELIVKLEEKNKRVELQGSARRVMRGVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD80</accession>
    <name>A0A2S5BD80_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD80"/>
    <dbReference type="OrthoDB" id="2529363at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="148" mass="15448" checksum="CCDB2F06E8481A76" modified="2018-07-18" version="1">MRRRCTPTLPLPPFRPLYDSSHIFETMLNLASTTRAALRSAIRTPASARLYHATAAIRFPTISPSAPPGSSATTGQNGAALDGSAKSSAASASESKAQKAPQKDAKEAAAGMEAADAKYGPGNMVEGNFTKGSKQQKEREAAAKQGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDH0</accession>
    <name>A0A2S5BDH0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDH0"/>
    <dbReference type="STRING" id="741276.A0A2S5BDH0"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="211" mass="23152" checksum="8F0204493FB8D269" modified="2018-07-18" version="1">MYLPLADDIGSAFDYAVNALAKRSTGGDIEPFTISHTQWVTIYWIEGIIVLYLFTWNLYIARSVLFPLKLCAVACHEGCHALLGLLTGAKIYSIILDPNQGGSTRMEGGWAFASLPAGYIGSTLIGAALIFASFDLKASKIAAVPLLVHLLLVMFWARHSRYTMLFVSIPMGLIFILYIVAHGIFLRFLLAALGVMNGPCEYAPCYVETFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDH2</accession>
    <name>A0A2S5BDH2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDH2"/>
    <dbReference type="STRING" id="741276.A0A2S5BDH2"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000003">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="470" mass="53901" checksum="B03D29B1598804CB" modified="2018-07-18" version="1">MPGMQVDPPAGGPGQSACCHSLVRTLRDPLTLLLGRSSALDKLFADDDLKAMLPKMDNATEESMGDLSNPMVMRTYYSRLLPWKAMFLWLNQSYVPTRQFTHREFAFTLQNEAYLRYQSFAGADELKQEVLRLNPSRFEIGPMYSGRPKDRKALMKAAFRPMTRELVFDIDMTDYDSVRTCCKDKKMCSRCWKFITVAVKVLDEILRSDFGFRHILWVYSGRRGIHAWISDPAALQMTDEQRSAIVRYIDIVKGYTTMEKRMALHRPLHPTVERAYETCLRSAFANVVLKDQDCWKTDPHQWEQVLGLIPDKENVAELLKKFPASSTAPSIDRFKDLRKAHTRATPKQVERHDQAVQDLQIQYMYPRIDTEVSRKLNHLLKAPFCIHPGTGKVCVPILASQIDSFDPDTVPTVGKLLLELEELSRRGDTAADWGKTSLRPYVELFERHAEAVAKEKAREVKAAKAMSMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDI5</accession>
    <name>A0A2S5BDI5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDI5"/>
    <dbReference type="STRING" id="741276.A0A2S5BDI5"/>
    <dbReference type="OrthoDB" id="2530451at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="288"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="619" mass="67050" checksum="38F55DE799A43F47" modified="2018-07-18" version="1">MLAYSPATFTAAPHFAGLASQFDPSPYSRQSRLQELRRVEAAIQAEIAEEEARRRHLAQRAALEFALRQQAEERRRRQEAEAEARMIAAAIARRQERAREIALARYAQEQEYRRRVEYARQQQHNAQLRQQLEARRQRARQAQIAPALVQLVVDIFAAQQEEDKAAQRNEEPASTAPVKAEKHVEFALDTRPPVVAKPADAEKVAGETSPGAIGPELEDAAKVLQRRFRRHAARRSALEQLSALAKDLVTRRREFEAPAELHFQSSPAASDLTLTPSSAPLAYDKSNKSFLGYEDFLVSLLSKIDAVESNGDKVVQRARKGLVAQVEKELSRLDELKQHEWERQSGTSSAASATASDSEDGVEEEEHVASALETADVVAQDLDETAVPSSVLSDIPTPANDVATVPADDSTVDTESAGHASPEQTEPVIAERAAAATVAAETDSTPTSKDIASASATTELPTPRAAEPSEPTHGPTSTTELSVPHDDEADSTASSSDDEIDAVVAQVLNRAKALGEQVEALERADRTDTSSTPENASSIRDDESGEEIKNKSPQDEVAPAEAAAPATVVATPESETASRPTDAKAVAAEADDSTKEEKIADVREEDSKSEAATEDFEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDK3</accession>
    <name>A0A2S5BDK3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDK3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDK3"/>
    <dbReference type="OrthoDB" id="2421327at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="2">
        <location>
            <begin position="208"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="888"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1062" mass="113891" checksum="F804C8A562A7D119" modified="2018-07-18" version="1">MSGAGNLYGAQPGVASSSRSLHDDPTHADADYDDDEFDQLEDDDASDTAVGRGATGGGARAGPGPSTLAYRGEKKRAASPAGSNASLDSNAGTPAKKRKAHGFPRASTGGGAAGRYVPPPKPHYTVIRSANNSRANPHVIRIHPGVTDADESRWPSAEERRPSHKVDGRENWYECQPKDVGRHKSFREKLGDELSKLLNLRKSATENWIVEDLPEHNLFTVHHTITSGKPRTDVYVFGTPTTPKFRTANEFTPHVYWLLEHGPNDDLKCACKYCSKQKQGDVNRILNLPVKQTASPARSSSPVAPNAWTATSGPRVKNPPNYAYKPSPLAAGYGGASGPSSTSSSHSNLNVNIVRVASFNDPGGDRLLGPNASAAAIDKAKRRHMKHMEDDSRADAKDKSSNKGKGKAREIDDIARLKKKKKRVSSESASSSEATRGNADVLEMTGANDIADQASSEDEADMVESGPAYRGSFTNRMRDEDLERCSAPRRAELVWAELARPLVGTKSVLKGKVVRHWPGLVMSREIRNEAHVLPQGASVSDGPARDEHIAMAQPSDVESEHGVPEKASASYSTGTAGTTLQAGSPPRLSTTGSTRFNVRLLAISDDLRLLREEQILPWLQHEPLRPLFAELPKLLQDAEAVRHIWDGERIKRDARLFDVTDGEEPTTLDDALVPLGLAMQIAAHIITTFTLNDRYSVTSRFLTPVDPSDPIHQQEREKQLKAWAFQSTHYGAELIWTGDFVRIFDGDGNPFSTLNYESAPTSLGERALFMKVFAVYKENDGPRDQIGLVKLGGELWELREFGEVGGQVDSVPGPTDVVVGSATTSVRADGGQSAMSMFEKRSSPPRASAVTTETGGLPTASVFTAPSTPPDTPPPAGASDETAPMRNASSSASIAAGSAPQRPAAADDASLPPPPAGYYWYRLTSSAQQVHLTIDFLAGRYHPLPKSLNSPALIKALLPKLGNDKDGEISDSDQRALVLAGLAPAVRLFNKVRTVLSAIGAHVIAAIDPSTSQGGYYSGVRQSAVVFATENAESEALPHLTGEMLLPSAAGAADITPSLVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE39</accession>
    <name>A0A2S5BE39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE39"/>
    <dbReference type="OrthoDB" id="2528220at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="438" mass="46439" checksum="B44D3C655A91BF04" modified="2018-07-18" version="1">MPRRRKAASPAEQLPSPLPPPPPPLTAAAAAGPPFAAPPPFYPTDPSLAYGYSYPTPYDSPYYAPYPVGDPGPSSLAYAAYGQLQVQPQEPIQLEAIPSHYAEALERINRTATASQAGEGSPAPGYSASPPAAPASPQQPQRAAPQRRKRAVEVQENEAPTRAPPLQKKRGKGKGKEARSSGVRDDSPAPTPAATVARGRKRRRRASSSLARSGDSDDSRSDEDGSTRRGTSEPALGMESRGDSGSDDGDDDDDDDGEGEQHEEEEEEPEPAPRRRGGRRRLNSPSYVAPPPKPGGIGAGGGPGFEGFFDSVPGLKGLRVPPTVPSLLKGAENLKALLLASFVEEEDDDGDEMAKGGGALQQLTPEQLSELERVGDPKYATALLQFVADRIDALDTAYSALNEELSKAQIEASVLGNVKNLLRVHREAIRDKQRRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE62</accession>
    <name>A0A2S5BE62_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protection of telomeres protein 1 ssDNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE62"/>
    <dbReference type="STRING" id="741276.A0A2S5BE62"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="9">
        <location>
            <begin position="448"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="612" mass="66500" checksum="1AD40082AFF79D4E" modified="2018-07-18" version="1">MTQPSAANETRPAIVPLALSAILNEPLPALGAFRGRVTDKRPHSKHTQLAQLTLAAVDRVEPIGSAFRVELKGSWADKAVRRLMKGDILVLLTTGMVILGNEGNKTQGNGAPRVRFDQGVTGWIRRKDGSEELWSFPDPERRSKPLSAATQPKSQSIPSTPSISATSSERTTAPSAPTNTADPAAVLLAAPSVDAETAPPTVPKVVHSAPYEGSRSRKRQRRDETLGWGLVTPGPRYLSLEALQELSQTTVRAALPAKRASIIAIVASVSDICPPKEDASVQNWYRQFRIVDPTKMDEAIELQWYWPTREGLPDLSAGQILLARNLLVRALPNGSPMLLSGSFSKTAHAILAPDLFRLKPPPGVAPATMSVGSSAQGVKDDVWVVEPSPEEVAYVRRLADWARRNSSTVDSARAKTAATAVSREETSNGSAPAVKVLPAAAGRPLLHVRDVEEGKFCDLLGMVTKIHTPAKLGTVPSNQAVSLYLTDYTPHARLHEYPDPSPVGLPGRLVLQISLFGSTSAPLAALMDVRTGEVKRGRLVWVRNVRVKLNRVGGLEGTLVEETNPKFRTRANVEVVDLRKKDHEEKWGPRAREIQSRHREYWAARSLLGARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE63</accession>
    <name>A0A2S5BE63_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE63"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="77"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="645" mass="71728" checksum="627353F916605311" modified="2018-07-18" version="1">MTTASRSSGPDAKATMQESPMPSNRGLRGSLAPLAYILIRWLFRFVLDVFYSNVVVEGEENIPRDGAGLTSSSSPFSVLTANHANSLTDALLLVTTVPKDRRALLRLTAKDTQFGRGTFTSWLIEAAGTLPIKRPKDHKGEKVDNSAVFGKLIGALEKGDMVCLFPEGLSRYYPEIGPLRQGVSRIVSETLTQQKDNEDFRLAVQTTSIVYLHRNLFRSDVLVTFHPPIYVSAVTHPDLVIKAVADRAGSQRPQDGTASPDAHERAVRSLTASIGASIRSGILDAPSWSTIRLANTCRRLYAPLGTRLTLGDHCRLTQRFVDALCGRRAEKSWDDIVRSQDVGVEREAGEGQQAVAQRATRPGLKQRQLTEEVLRTPMSNKAPAPASVDGGATTDDDSADDELVQLRADLKTYQDLLYLHGIKDDRVRNPRLLKRRVVLKRLLVRLAGSLCLLIVSTPGLLLWLPILFMAKRGTDRLIRNGPVFDTYDEVAQTKLTYGLLTGLAVLTLASLATLPFFPLNLAFFAGLMWLTLRFLEDLASSVRAAVALFRLLLLGKRQLVLLRSMREDLHRRVERLAVERAGLPKDAEVFVREREKRWRRLGLGLGLVDAVGERLGYFNPRRRRKKALKLFDQTEYAEDEHAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEB9</accession>
    <name>A0A2S5BEB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEB9"/>
    <dbReference type="STRING" id="741276.A0A2S5BEB9"/>
    <dbReference type="OrthoDB" id="3005035at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="397" mass="42954" checksum="C99E2FABBCF00178" modified="2018-07-18" version="1">MLNYSHLIDRKPPRTDASPPRHPALPSNPVLVKSLPRTSEISKRAEQYAHSARKQHILNDALTSAVETPLDARPAPSADDKQLAASSDGAAGTAPATTRSGPGKRGGGPYEPFEVLRAIEKKDLAVILDVKSHQFDLLVTAGPGQPLPLVYAIRMGKSHADMAIVIVGAISRRVNDTSDDELAQKDPRTLATLRAIRANLKIAISASLSGPDGDTSLLSSFLQVIVMLEGNKFLQSSTSTLSLALRSPLASKPVATAQRLMLKWVSRELAARQVASVEEYVANAVGDLVLLGLWSIVQDQLARGQVDSIPLYYFARDDRIQKAVEERMSDLRRRKGSVTQLSKQVRSRLDVALDVLGRRSLNGRERVDRLRRVFDEGEKREAVVGSAAAAAAASESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEL1</accession>
    <name>A0A2S5BEL1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_1815</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEL1"/>
    <dbReference type="STRING" id="741276.A0A2S5BEL1"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="169"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="313"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="384"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY75183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="467" mass="52729" checksum="72DD28CAE6293D53" modified="2018-07-18" version="1">MGIDLQLLQNDKGGNFEAVCASQKKRFAPEELAHDVLALYKEWTKTQFEAQQLAKQVNALKKDLGKLMKNLVPTPLVQEKKLDEAEQLKAQKSELDTQIAALGSKAQEQETTMRKKANTIGNIVHESVPVSDNEDNNEVIRTFYPKDANGDSAPPVKGGALTMKEGILSHHEVMYRLGMLEMERGTKVAGHRGYYLVDVGVDLNQALISYGLSFLRSKEFKKIQPPFFMNKAMMGKTAQLEEFDEALYKLEGSNEDTEKYLIATSEQPISAMHADEWFDQPNEQLPIKYAGYSTCFRKEAGSSGRDVLGCFRVHQFEKVEQFCITDPSSSWEMFDQMIANSEEFYQALGLPYQLIAIVSGALNNAAAKKYDLEAWFPHQGEYKELVSVSNCTDYQSRSLEVRCGVKKQGDTRKVYVHMLNGTLCATERALCCIVENYQTPEGVIVPEPLRKYMDGVEFLPYVRELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BES5</accession>
    <name>A0A2S5BES5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BES5"/>
    <dbReference type="STRING" id="741276.A0A2S5BES5"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="35"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="542" mass="58326" checksum="61A6DB11BD80782E" modified="2018-07-18" version="1">MSSSPNSPAAKAPLVPETDYDVGLNRDGEPVKDPAFYRLLGVVAAASDAELKKAYRKQSLRWHPDKNVGNPEAQAKFQEISEAYTILSDSNSRAVYDKYGKNSAMGEAGGEEVMPDPGQLFSQMFGGKAFEDWIGEISLGKEVSKAFAQAEEEEEEAEAAKVDGTASKPVSGASTPAPQSTIHSEAHVEPTVASTTATPGVSPTGTAAAASSTPAAATTAPLGPESGATPAASASTTTGGATPAEHHHAKSHLAGKPPKLSAEQKQKAYEEEKKSWEEKRQRVETLAQKLRERVRPFVEAAKPGDKDDVETKRFAERMREDARDLAMESFGVELCHLLGEVYMAKATTYIRLHRKPSANLLGLPGWWSRVKEKGTTLKEGWSFLSTGLDVQRAMVDMEKRQEKGDLGEDEMRQLEEELSGTLLLVAWKGSKFELGAVLRQVVDLALSKESPTVTDTVLMNRAKAILFIGAILKAVQPEEGDDERRELERLVAQANARRKEKKTKKDAHHAKTKAAASETSRAATPEAGATAAASEVPPAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BET2</accession>
    <name>A0A2S5BET2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor IIIC 90kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BET2"/>
    <dbReference type="STRING" id="741276.A0A2S5BET2"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="2">
        <location>
            <begin position="720"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="85985" checksum="5883F9A159E6A636" modified="2018-07-18" version="1">MSDAASTSTLTASTLVGTSTVTYGAVAPCPSSLLRSDDGQFAIVTRAEIHLLIPTLGYASKEVIDSSRAAARPLAGTKGGADALESGFKGKGKETDELAWLKTAAVLDKKNVIKWSDWADEYDLDMPGIVESHWRAASWSPSGLSHLGGCILGAITTNGEALLYEAKKNATKGEWNELADLTSGLVNELAPVQSGIPVQNPRMRRKMVAALLRCQTSAIAWSPAVPGVTSDLSLLALGHRSGEVSLWRVNDARVPECLARFSAADKVNIVNVLSWSDWTATHELATAQLAIADGDGRVFTVEVKQPLGASASADVEVSDALPVCEADSRGATQLCWAISPTSGSDQLAYTKLGTVCLASVGQGADGTVWEVQEVELPLVSQNQWTGSTPWAVCSGLAFIPEHNSLLVSLSSSALYFFEVSPALRLVHQPDTHSAATLTRAGRELFEEIVIRTGAPGMTRSKPASGAGSSAVGRISRKDGPRVMGLVHLEGSAHADKIGKVAFIFETARPDSSIYRTYGQFRTYLVVADLDDPTMSDVEAVQQVRQALSRPTNPRTRSPLKDLLLPLHYIRRFASSADFVSALLELLVAPLSIHEDLSLPDVETALREKFEARIWAEEGLQILRQKETLARALMRDEDLAAEMRHDAKRVHTDLLRSLIKELLAKTAALLGALKLQETAKTVYSRLLLASASLHPVAESDENGALLPADELARAYEQGNVLCPACQAPVPLANTRYACCETGHQWERCSITLDLISTVQVRTCTACERKALLHSTDGVLDELLGLATCCVYCGGRWMRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEV4</accession>
    <name>A0A2S5BEV4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEV4"/>
    <dbReference type="OrthoDB" id="2529214at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="395" mass="42396" checksum="8469E7FB028E17D8" modified="2018-07-18" version="1">MSTPRSRSRHAMLPPMEWADSWTPRAQAEIAHHGEVPRLFADCVSPKSRPASPPVLATDKLRAKFDGSAVATWIETANLDSDFSLDGGEHGAPQQDELMDWDEEGSTDEVSEPRRRNSLGLALDLRDLKKSLVLSCIRPFDPALLSSQSRPYPSPVSPATTLFHRHTATTSPAPSSAASEAESYFDVQRNRQFSTATSAYTSNYDGDDEDCKEDAVDATGRDLPPSPDLIPISLPSSSSAIPDLPVAEAVTPLPAPTAPSHPLHRAHRLSMTPVATLDSLDLPAISEVSPTLPTAPEPPRVRKSSIVDLPLVSAVASPVPAFATGASELGLEPLLPTPPRSPGARLRMMPIVPTATTSTSSLETVRSARSLSAATTRPWAPSEAIPQLFKRQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF88</accession>
    <name>A0A2S5BF88_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF88"/>
    <dbReference type="STRING" id="741276.A0A2S5BF88"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="401"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="363"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="456"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="260"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="546" mass="58291" checksum="E02C6B50EF94A6D8" modified="2018-07-18" version="1">MSATTAARRSGSSVATVSAAGEHAPVPQATPQLSILRIKRKRTQQPTPLDALVIEQLEPSTKRRRGEPTSSTSRNVEPDAPARGIFRFAETVPLDSFSTPVKTRSLRDRIQSFLAHPPPGLARSSSSASLRNAFAAAGATADASGRTDSPGRRAQDHDAPASPASTSSRRKLPSALRAARAAAISTSSSSSSLHDSLAAPSSPRSAAASVAAGRTGRGHESSGTAASPRLAALHAEKSRLRYRVIEQRRAFFSAQAEAEEAARVERAKEDEEIRRGLRPPRVEDSRSRTKPVKEENATDEPNGIKIYEAVAELEDDSANPGRARSRDTQSRRNAPAPDPMQAAAMDQFGSMLNEYLSIQETITPTSPTVPHPSTFSFPTASDSPSVASDATTPAQLTDDEGDYVYDVYYRATEKPAARTAAADSTSEAMTSGTTAAAGFDVSSLAGLSRIGQLAGLAEDSDDEAQLLLHEKDADPSSEEEDNADQDSNEENDYRNDYPDEDEPDSDNNKVEFRDPQRAAWSSDESDGMEGDSDGSDGMYADSDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFI5</accession>
    <name>A0A2S5BFI5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFI5"/>
    <dbReference type="STRING" id="741276.A0A2S5BFI5"/>
    <dbReference type="OrthoDB" id="428346at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015541057" evidence="1">
        <location>
            <begin position="26"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="355" mass="39380" checksum="2B8783C6F944B797" modified="2018-07-18" version="1">MCGGYADRMLGMTTALLFSIISGRAFLAHWGQPAPLDLIFDSTFVDWSRPYNTTSGTSTSAVTHVDRTLPLDREAVHWFSIGWAGLDDIAPGFIDQLIANASSPYVQLDANRGTVLRSFTYPSVRPHLDRLGLTPTNAYSCLINYAFRPKRAALAFIAQYTSYFALPENFVVGIQIRTGDRSMETSESDRHTVGQFQRYFTCAEQLAETYAHPTQRVIYYLITDSGDLERDAKRLLGGRLVVTGLEQAHAEMHADSSNGQDAIRHATDGLMRTVAESWIFAGTDYQVLTADSGFGKIRPLGLFSDLAAGPRQYHDPQSKHELFTSFLTEDFSRHGSGLVPRLKSVSLADERSDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFJ8</accession>
    <name>A0A2S5BFJ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFJ8"/>
    <dbReference type="STRING" id="741276.A0A2S5BFJ8"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="67949" checksum="BE76ABABF24D740D" modified="2018-07-18" version="1">MARHADARTTETDSDADATSPLLPQPATAATARRQSLHGRTHASRRSAEDPDPELAAEEQLDDGETAYAKLRWIVSSLIIAAFIAIILWLALGDAGVRRSEGYRDPGFPGEDEVGYEGPTPTGVEALAAATSYPTYHDTSPISPPAGLETEEFNILHHLGNLSPWRTVNFGLKGTAQVPEGCTVEQVQLLHRHGARYPTTGAGTQRFADEVVGADGFKATGNLSFLNEWTYPLGLEILTPFGREQLFNLGVSFRTKYGALLKAGQKPVFRTESQDRMVKSALNFAAGFFGVPYQEQYHQLITVEAPSFNNTLAPYMTCPNAGNSRLTDGHTKRRNWVNKYLRDALPRIQAQVEGVVLTQEHLFEMQLLCAYELVSLGGSAFCAHFTEDEWRGFEYAHDIEFFDSYCALHSFDDDSRLKADDVVNTAFGQPAQAAMGKGWAQEWLARTFKQPLGQFNSTTNSTLHTAQFFPLDQNLYVDATHDTVISAVIVALGFQSLARSGPLPDDHIPKDLSYVAAATTPFAANLHSQILSCPNVNLGSSGTSKSNRHVRWILNDGVMPLDHIKGCAINEDGMCSFEAYTTWLRQDLQSIDWEHDCYADYAKPSRPIRDGRPPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFT3</accession>
    <name>A0A2S5BFT3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFT3"/>
    <dbReference type="OrthoDB" id="2529519at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="481" mass="51863" checksum="57EA9C8953B69E65" modified="2018-07-18" version="1">MPASTPLFDPAAFTSTPPRVLADDDCTPSRRGTPYSSSSSLASAASTSTPSLSAASSTSGEDERETDCLDLLDQLELEITRLNDPFLTQSPAMSRDNSQRSVSSDWGFPVVDESATARSGSPKPWRSMHCRAGDTPRSRSPSPNSTRLNRSPRTQRRSRRPSFTQNDIADLDIDAILEAYELDGILPSIAAKPTVPTRSPLRPAPSNATIREDVPTPRPASPTPSTASSSAMSLLDERFPHRRVAPFPTIPRPKSSASLRSVARTQRDAPHEIPPVPALPSTLHQPTLPTPPMRRVFTSFPMTSSPSPSASSVAMRQTRSCEARYSTASSTRSSATSSSGGSRFDRDSIRWSVATASTAASSVGDASDDVALGRKVRFDSVDEVDECDIEAHLPELRPAEPSVANRKKRDSCGLISWQDFANELEETLPPPQPMPRPTFSSPSHSLPRTSSRPFSPASSSRPVPPRMGRGLVHRGLPQSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFY0</accession>
    <name>A0A2S5BFY0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFY0"/>
    <dbReference type="STRING" id="741276.A0A2S5BFY0"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55044" checksum="37FDABE555DB21D6" modified="2018-07-18" version="1">MSRLHVSLPPRRPRSSVSTAPTTQTTPRPAPSVAAHPSIVEAHQPQRDPQQLHSPLSTELSVDTSFEVRLVWDFDTNLAEVPAAGLASPPLDQVPLRGDWYFKIEHIAEPPSLGFGIPYTALPSAVSDQTISVTLSLSLLVDGKPHEIESAAWPPERLGPGTAAGPAPHAGHRLPLSLEELKTKIGNFAPFASLQRYRLNAVFKSTLAGTVTAQANSPFDDFSKALRIALADPNCLPETKSVRLVFPRTGADDLELWTTDAFLKRISPYFKAMLDSGCVETVPRRSKRARLEEPGLAAESVGETSNSWEDSDDETDAFVLKNGFTTTRTEDADQEYNQITIREASHTTYRAVFLYLQSGHIAFAPLRSSFATAGDPQAVGASREQYLRDYHQANRSLPWPASPKSVYRLAHLLQLSDLQKLALEALGSSLTVSCAIQEIFSPTAMAYDELRKLLRDFVLKHLTTIGSNPTFTAQKEKAKRGELEGPALVMMEFLTAILEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG86</accession>
    <name>A0A2S5BG86_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG86"/>
    <dbReference type="STRING" id="741276.A0A2S5BG86"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="951"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="952"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121426" checksum="43AF0243DE78D00F" modified="2018-07-18" version="1">MDSNRLYQIFAASFEPDPNVRIAAELELKKLEPVQGLLPTLLQLVSPGHQPTGASSPVVRLAAAIYLKNRIRSSWRAPPSSASQDPSAAFLNSTRPASTPYVPIPPADRQTLKSNLLPLYAALSSGSESTEDDATNRKVKDQIGEALAKVVECDFPADWPGLVDEIRALLAADGQGHVEAGLRASAEVFNAMRYAARDETGEILSSLSTHLLPLLLPLANQILASTPTTPQALTTQGTLLRLILKSYKNSIIHTLTPAHQANEAIVPWGTLLLSVVAHPIPIELLGSDADPELREKHPWARSKKWACWALNRLFSRYGCPATLPKNLAEEYGPFAERFIGQFAPEILKAYLGQVEKMVGGAWFPSKGKYHILCFFEDCIGPKTMYAQLKPHIPTLTEHFIFPLVCLSEDEIGMFNEDPAEYARQFFGDFIADSYASPTATALAFLSTLVETRAKTSLLPLLQFIQSVVDKYPAQTTPRQKDGALRMLGALSRTAVKSKKLAPMLESFFGQYIVPEFKSPHGFLRSRACDLVEKYESADMTWSDQNALENTLNCLMNCITDADLPVRIQAAIALPELVRYERIRERMLPNLGRILQELLKLSSEVDLDALTNTTRSMVAEFSEEVVPFALELSQSLSESYRRLLQETLEAREKDPAGAEASYDDEKTLVMMNVLKTIEQLVSSAKEKKELVAEMEKGILPLIEATIRNQVVELFDETYEILDSLSFFQQSVLQPMWGCFEATYGLLKSGTQDYIHEMFGFLDNCVNYGADVLSTNTEYRRCVIEVFEMCMTSRMLGAEDRVIACKLAEALLLRLRGQVDEAIPVVVERCMSFVLSKGDDEDFTVTTTLFLHSLELVILAIAYNAQLTIAILDRHDWTQQFFAQWCKSLKKYTRVHDKKIILWAICSLFEWLSGAGAGSPLSGNVGQLVGGALEVFKTYPRALAERKVAHENRDLEEDDFDDDDMSDDDDLELEEEDVEDETDVRPGGTDYLAELAAAEARRADRLGAFDDGDSGWSDEILWASPLDEFDSYQRFSALLATLQTQNPTLYQSSLSSLDAEQQTVLADVATKASEGGDAVVAAKAFAAMQAEDDAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGR6</accession>
    <name>A0A2S5BGR6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGR6"/>
    <dbReference type="STRING" id="741276.A0A2S5BGR6"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="218" mass="24125" checksum="2904032840C30B7B" modified="2018-07-18" version="1">MSLLHALVARDDTILAECDKSSGQYSNACQAILSKIPPNDSKLTYAADQILIHYQKKDNVTALVVAEDTAGRRVPFSFLAELHRKFTASFNANEIADSVAYGLNSFEKEIAALMRQYEENPPQDAIKAAQAELAATKDVMVKSIDAVLSRGERIEILVDRTDEMSHQARAFRKRATVVRRKMWFKNVKVLFAVGFSAVLLVYLLSASVCGVGLSHCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGS6</accession>
    <name>A0A2S5BGS6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ribosomal protein subunit L20-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGS6"/>
    <dbReference type="STRING" id="741276.A0A2S5BGS6"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23695" checksum="BA726BABB9E7E262" modified="2018-07-18" version="1">MFRRAINASAPAYKAQASAAQPAATVLRRARDPLLSSRTAQHYTLESGHSFIVRPPPSVIPATHSLPPQPSASTSSSSSSGLSGPFAQISALTADQSLLPSDSIENQHRLPSIRSSSLRRASTATPTAELSPDQVAQLQALRRSDPVRWTRSALAREFGVAQHVVGMLGYGQGPEARAVERTRRRVVEQDRLADKAKQGWKRTIAREERRRRRSMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH34</accession>
    <name>A0A2S5BH34_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_0787</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH34"/>
    <dbReference type="STRING" id="741276.A0A2S5BH34"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="15">
        <location>
            <begin position="440"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="664"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY76064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="706" mass="66814" checksum="2CD4638D32A313A2" modified="2018-07-18" version="1">MAFNFGGSGFSFGQPAASTSTSAPAASAPAPLFGAPAATAAPATGGGGLFGSVAPTATGASAAPTFSFGAPAASTAPKPAASGAPTFSFGAAAAAAPATSSTTPGGGLFSTPGKPATGSLFGGAAPAAAGAAGSTTPAGTPAPAAPLFGAGAAAATGGGLFGAVPGGGNKRESEGSGQDAAKKPAPTFSFGAAPAAPASTTTSAAPAAAPLGLFGAKPADNAGASAPATSAPSLFGAAPAASKPAEAPKSFFGAAAPAAGGGATPGLFGAKPAETSTASTGTTPAPSLFGAPKPAAATTPATTPGLFGAPAASAAPASSAAPAAPSLFGAKPTTAAPAASAPSLFGAKPAETPAASTGAAAPSLFGAKPAATAASTGTTPAATAAPATFSFGAKPATSTTPAAAPSTALSFGGGAAAKPAAATPAFGAPAAAAGAPAVAAPVPSLLRGKTLDEIVNAWSVELDERTRDFVDVAGEVREWDRVLRENGEQISKLYNSVLPLSPLQTNITSSLDYIESQQADLSAILDSYESQISDLVNQSAMSSSGLGRSANGFGASVNGGSPAEKERERAYQLATSLSQSLDTTSTSLSSLIQTLNSLSPNSTASGPGAGANGADDGAGGDPLAQIAAILNAHLGSLRWIEGTTDALRTNVRDLEGRVADVAGRMGGTQNRLGGGTPAKQQQQQQQYALGASLGGQGRSSPFARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH70</accession>
    <name>A0A2S5BH70_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Proteasome activator Blm10 mid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_0828</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BH70"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="12">
        <location>
            <begin position="562"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1542"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="1964"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="11">
        <location>
            <begin position="2035"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="773"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY76105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2138" mass="240274" checksum="215BED672E064A66" modified="2018-07-18" version="1">MSSLTSRSPSPQPSERGDEQDSLRQDLASMEDDAIQVDSPEQDPVDLDDDDIDQSLILGGTPSPQYERANPFDGAGGEARHKSLSPKPASKKRKRLITPHEKPREEQLDYPQNLPYKTESLEEMDAKLEEIVRRLVDCTSETRLFSLPSSQAILLTSHAFWHLVAMSALNPEWNHRLECWISLKYPMKRELRAKLARLYFELSVLPGMDARLVDIAVNQAITLLEPKKRIDISDLQLPWRPLYAILEKELFPKQRKTGTTNVATTLLSLVEYSQRFFPPHEIPAMLATFLPRLSPNLNSIIAAQAFCTHFLPISHPQYYLPAVFKIWEAFSSEIYDEQWLDFVERLATLHVDPRHSHPDIVDELRQMVKAAGDYVPEKTRVEDLLEEHTYSHRKTGIPAYIFGMQDGVTTPGGSPALPKWRGLRKDVGIFTDQQFAFIMTKCLRSMGVPVGGGTKAGASGVAASDFATQDQAASGIASTMRRPTERLSSFAAIIVYSMSADSKPSGATPFGSSVPSRSGTPYPGQKSTPGQSAGPGELLSTALGILKKQRTYLGGSKALDALAKFVQATEGYFHPSNYGKWAPKLGRFLQNVTWEFLKRWREEERKECKTPTEWRLTPTIKREFVLTMRTVALLSMFSRDPITIANAQSALKTMALLEPDLIIPAVLERAYPALETLTETHRTTACITALATLSAPMISRDNYPAGAKHLVPLLELCLPGLDVNDPIKTMSTGMFVLQACARFVLDDLTRPELQGSVEAAGEYGMALESATSPTIPTVSLDGGDDPSSSARRSPTSVNKKEEDEAVRTMTAGFPDWISSFMRGVLAVFEALPEPGKGSRNGGKMEDQMTQTLILSPSMFDLALDIVFNEVSNNVRTNSARVISQLVSSFARADSAKTLRKFFRLCDLRIRAELESGAGSTRSTRTDKGIESDATLHWWIGVLTGAVTNAGENLLAYKDDFKALLQVMLEACRSERGYTTSARVLAIALMTLTNTWVRDYRSVNADEWQSDEFKRRSHESWGRLYEVKDVKIEWHVSTPAEIDYVLELLRELVVPALERLETLLADAKQTGDLLSFEWISDFCRLCNLVRSALSGIPSLALFPRPAEAGAPASDAGDEVPEFIDQLPSCDTGIPLTDPSDPRHRFVSELRTRAGRFFHESVQTLKTTQQQDTIDCIKMVIASIRVLELDYPCDISAHESIKKSYDFALNISRVTRNQKQFPRFVWVRRASLYHASRLRLTSFYRRRSALDDLLIHDLCELSLSVYLAVRKSAQRGLGSIIQYYDGTRSLIYPRLFDALKPGSDHDVMKGALYVLGAKAPQNMAILDWRWGPQYLLALLGCSHQDRPSVQNLVKTVTHDFIIRLAEPMTLKNQVDSDSLIRAADQLEPLTSVEQDQDLVARVAAKARARVDQKNEAYDQLVPELLRFAGDPQTHWRYSLIATRLLRAMIRRDQPQRPSLAVYMAQQLVSELPNQRVHAMLALTKMLHFVKIRTTCSGSDERLLLQQTSNPLKRKVELPHPLPADFTDKFIASFSDPITPTTNLMDKQNTGWLVWGDTVDFYAVPPEEGSVFFWDHTSKDALEQLREIILQPGYWDTFIGHLAMEKGVDYLAADVCMLVKSIFQVFEDEPCKFVLPALDDLVADRDNRHKQRAAGELIGGMVRGSKHWSLSKQRALWEWLTPKLPTIFEGMTPETQTSWEMLSEYILTARDPRRNQPLVDYLTSLRLDEESGEAFNESKKQDLVGTAMKALGWHFSPWASSYLEMYSANITHPYQEVRGAVADNLRALCELRQHPSFTSVEALLRDSQRVYGDVGAKSLVSVDEAYEARIDEFGHKLAAWRAERKPASEGTQTYDKASMTILTWIWGSVGEVRTSSVFPFITKLLPEFFRMQECTDNQELSRMASRILLACAALQFPQYRVRPTMMQFIELLKQSSSWRVRLDVLLPLQVFYFHHLYFLDDDLVSQLVDQLCHLLRDPKIEVREAAASTLSGIIRCSQRSSINSLINRFMKVLRTTKIPKRRDAQGNEVAGYQEALVAAHSAVLGVSSVIKAFPYEVPPFIPAILIESMSKHAASPVPLSTTVRATLADFKRTHADSWETDQKAFTPEQLADLQDLLTGSSYCELGCPGFRCRPRSCETRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI24</accession>
    <name>A0A2S5BI24_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI24"/>
    <dbReference type="STRING" id="741276.A0A2S5BI24"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="525" mass="56337" checksum="F6DBB46EE13E95F4" modified="2018-07-18" version="1">MASLAASASYDETKKDAGDFAPDSLSTPPQPVHNEELEKMRRKERLSSTFTVICAGFALISDGLQNNIMTLTNVVLGQIYGKKYTASISTRLSNSLTVGTILGQLAIGVVCDLYGRKHGIVISTFAIVAGIIIVTAAHGAHGSLSGFFWCFTVGRGLTGVGVGGEYPSSSASAAEAANEKMVKQRGPVFILVTNLVLSFGTIFACILYLIVFEAAGGIHANLNTVWRVVFGISLLPPLIVFIFRMRMLNSQLYRKGAVQSGVPLRLTVKYYWKSLIGTAGAWFLYDSDTIYSCCKRPQHPQLTFYLSIQNGVFSGTIIASLVKVKGEELIRKTAEWQLLLGVIALPGVFVGAALCNRIGRRNTMIFGFSGYLIIGLIVGCAYDKVTKIVPLFIILYGLMQSFGNAGPGDMLGLTSSESYATAVRGTCYGFSAAIGKVGAVVGNQTFTPIKVHLGQKYTFIVAACAGVLGMIVTYFFIRNDLGGDLADEDARFAAYLESQGWTGHIGVKGTEALIDEEDSVIKSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI29</accession>
    <name>A0A2S5BI29_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI29"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="53543" checksum="AF51682BBF6E8DDA" modified="2018-07-18" version="1">MLQSTPHQAAYTVIPSLKSFLHELPTSYHPTDLCSWYTDARTDPLHPALLASVFFSVAVWIVSEITGNVSQVDRLWTTLPLMYSAHFTFWPWITGQVAHAYEIDHRILLVFALQCCWSARLTYQSARRGFLNPRSEDYRWPIVRNKMPTLAFKVLNLVFIAFIQNFLLLAAEAPVYLLLTQSLPSYGHTSILSRLKPYQATTDRVPLNVADVLLAVAFVTTLVLEMRADNQQQAFQNLKYGAIDKQKKGKPITEEERKAIERGFVADGLWAWSRHPNFACEQTTWYLLYAFTVLPFLPVTQSFTSHPLSTIGELLAPTALLPASKRAYVHASKAVPTLDYILTILLHPILYLRANLPHFSNVDFLRSEAARAKLEALAAWREVKNDEGAHWNYSIVSPLTMSMLFYSSTVLTEQISGGKYPLYKAYRARVAKFWPALTPLKGLYLALTGGRRGKVERQIWGADGHGRKIKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI86</accession>
    <name>A0A2S5BI86_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI86"/>
    <dbReference type="STRING" id="741276.A0A2S5BI86"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="116" mass="13024" checksum="8D2DB621033BFBF4" modified="2018-07-18" version="1">MFAAFRTAARATAGRRLFATAAPGQASKTEFEQTRHAIEHHAAQSAELWRKITYYVAFPAIIIALLNAKNLAEEHEAHLEHMKEENGGELPERIVYGTYTPFYNPRVNIPIEGADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIC8</accession>
    <name>A0A2S5BIC8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIC8"/>
    <dbReference type="STRING" id="741276.A0A2S5BIC8"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="141" mass="15747" checksum="81B6FCCAD14C3585" modified="2018-07-18" version="1">MASHNKDDNCIFCKIIAGDIPSFKLIETDNLFSFLDIGPLSKGHALVIPKYHAAKLHDVPDEHLGEILRTLKKIAVAQGVENYNILQNNGRIAHQEVDHVHFHLIPKPSASDKEGLVVGWPAQKADMAELKAYYEDLKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIZ5</accession>
    <name>A0A2S5BIZ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIZ5"/>
    <dbReference type="OrthoDB" id="10610589at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="476" mass="53108" checksum="5E28A64188AF3695" modified="2018-07-18" version="1">MTGLETLPVEILQLIFGYTLPEPLPILSHAALEPSPPSCLGSSTAAASAPCSWTTFPTRSAYLRTYALLSKTWSDWARREMARHVVLRTADQLRLFLRQRPRPYSTETLRIGGVERNGRLLDASRLGEVVDRVRWVRQVWLVQVENVDLRDLRNLQDLRALICVSVSVSFSSASAQQPVPSAPPCFPHLHTLVLHQIHVSPFIRTILYESHSFDQLRVLAFDSAEVVEQIFDSDPEGMPRLVAMRPGHDLQFEYYTALDAVQDESPREDEDGEYDRSERRRTGLISLSASSNFLGCFEHYAPWLPDSIRRLSLDLSGGPEATSLPPGTRTWLDPGVDAFVTAANRAASARRARAAVVQLGQGDDGDDDEVDTTAFDADLFLEQLDEIVLPADWFRLDPASSTAVQGQAALDRAEMPDEVFACFERLRTEHGVRLVRPPRSVVRLEVDGADEMAPQDSLVPWRFLVEAQETLAAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ31</accession>
    <name>A0A2S5BJ31_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ31"/>
    <dbReference type="OrthoDB" id="2538401at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37556" checksum="5BE724F8858C3227" modified="2018-07-18" version="1">MSASTGFSLLGGLPTRTPDLAASIVFVTAYVLLVPLAVWRIAVRRTRIGVLIRPGIVLILRIATYVIRAIISDGKPSTELFIAEQVLLLIGLIPLCEPLVSLTRYHVRRDWVPTPRQPEQDKETTNIDRALRLLRLVVLAAFILGATVSRLLRSVTAFKSTDTALPQVGGQAGSAYDDPSAAAALQPQRYATYGLTLAVIVAGPLLATVVTATEALPRRPVLFLYACALCLAIPTIYKIDLAVHPVSPVSRGAKAAFYLLNSLPEWICTTLYFAFDLDALFDVNNGEWKHKVAKRMEDGKWEGPYMSKDAYRAASADRLPLEDGVYGGLPAYGAPRVEATGADIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ42</accession>
    <name>A0A2S5BJ42_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Starch synthase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Amyloplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ42"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ42"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45825:SF11">
        <property type="entry name" value="ALPHA AMYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45825">
        <property type="entry name" value="GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0035">Amyloplast</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Starch synthase catalytic" evidence="7">
        <location>
            <begin position="112"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="721" mass="79934" checksum="25B37AB68BA3914F" modified="2018-07-18" version="1">MISRRNAGDRKDSLRRRHAGEAGNESHRLSEVLTPVQRPESKRTARLQTLARLARRRWRLVVLVLALAAMLGHVLLLALQRPPLVIPKRLVPAQEYQHLDLSTPLNLPEATRILHVTKEFGPATMGGLGVMLTALASAQAKSSRLSIAVALPHYSYLSAQLSHSDVRPFVNLTILVTTRPWYRWTLRTRYYRCPVSLLRWSPGVESTIALNETDDAIDVYLIGPSDERPFSAAFLAKDQGDIYSAYKPLKQEWKDLYFARAVAALVRQLDEGPTATLDAVDRVVDVVHLHGATNAMVAHFMRADDARAAQRSAVVYSLHDSLDEVEYSNLVKNVEPFLPASAATGLARLRPYTYRRATQLFTSALGIDLSDVTTFVSRSIAADIVGRQFRFHLEDLVMPSIAAKATDGDFIGVTNALDLSDPNKNPFTSPILLQAGLAFPALPEGVANVTTSLASGQVPLPLIAAKRRARQKLLERLPRLFTAEDRDRPWFLFIGRYQYNKGCQFFATLLEVLAQSPTSGRLILLGARNNYPFDELLRLSRLYATHLTLIDDRTPATSHIQRDYGPILRMASDVAFVPSLSEAFGLVAAEALLFGMPVLSTGVGGLREFLALMQPTASGGLPASGNSYLFDLFPEQDTPATQGAERDYSQSAEDVRPSDELLAPARVALRMQAQQAVRDWQVARDQTSPEERESFARRLVQQALSLQWDRPGGPVEEYSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ76</accession>
    <name>A0A2S5BJ76_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0075</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BJ76"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1115"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1143"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1170"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="467"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="656"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1242"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1310"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1357"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1311"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1381"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1436"/>
            <end position="1463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY76823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1492" mass="162941" checksum="7F4D21B75195050B" modified="2018-07-18" version="1">MDSSRQQRGQLPPGAGPPPFRPAYVDRDSSDSKQSAMLPPPVPSPYDPPQRPAPQHASSSGGFDGGAKVQFTNSAYGDDNLSTTEVPLVGYQYQPGGGRLHPGHVQPVASTSAGAGGAANGADFKRKKSLVRPDRERVDESHRLYNYRQHAAAMEAEGRGTAAVSRTGHYASAGLPIPVTPAEVSGRAVGPGIAAASHGLTDSTTAAAKPNLRRGKSILAREEGTETESGLNLFKRSGTTRRRAPKGQQALPGGAYEQNRRAKKAKSKPMSPWMIYCQIITACLPTPLLKCFGFKTKDRRDAFREKLGLLSVIAVCMAFVGFLTFGFTQVACGKPGLRYRAGTITAGSMIFHGYDYDLDRFSHPAAAGIAEGSNPLYDLFDAAAKDGSFLFQKVNQKCLDVITPAAGTGIPHNGNEMGWYMPCNMFNQYGSTTPNFTAYAEGYTCHTQGDARRQFAELTKSKRQGQVYFHWEDLKNSSRNLGVYDGAVLDFSLLNWLDTSQVAYPPLFDQLRAQTNNNFTGRDITSLMINSGQRKAAECLVDVIRVGFIDSKSFGCVASDIVLYVSLVVIIGVVTVRFLFAVLFGWFFSWRIGKFPEETPDQRRARDAAIEAWTNDIYRPAPARYRPTVAGKSQKKSMLPKTSRFSKGDLLKADNTSQLPSLSKKGMLGAGMRNSPPGSPGMPAASRSSTSLPMSSFTLDGLARGLASEGAMGVCPFPLGDVVPQPPADYEPFNYPLVHTILLVTAYSESVEGLRTTLDSLSTTDYPNSHKVILVIADGMVKGSGNALTTPEIVLGMMKDFVVQPADVEPQSYVAIADGHKRHNMAKIFAGFYDYDDNTVERSKQQRVPMLLVAKVGNPDEQRDPKPGNRGKRDSQVLLMSFLQKIMFDERMTTFEYEFFNSLWRSTGVSPDRYETVLMVDADTKIFPDSVSRMVACMVHDPDIMGLCGETKIANKSDSWVTMIQVFEYYVSHHQTKAFESMFGGVTCLPGCFSMYRIKAPKGGDGYWVPILANPDIVQHYSENVVDTLHTKNLLLLGEDRYLTTLMLTTFPRRKMMFCPQAVCKTIVPDTFAVLLSQRRRWINSTVHNLFELIQVPDLCGVFCFSMRFVIFMELAGTLVLPAAIAFTLYLIIIAIIPGTVKPIISLVLLALILGMPAILIVVTSRRWAYLGWMLIYLLSLPVWNFALPFYAYLHMDDFSWGQTRQIEGEKRGGAAHGDKEGTFDSSHITMKRWRDWERDRRYRSGSHSRSSTNGDYIPAGRDRPDSPHRGSIFSSNDGSTVISEARAAGGGYNLPRYPTELTLPAPLAPQSVSATSSQTSFDRPSGVSQPMPAHRPSHEYPVYQGGAYDAEDADRPILSQHSPPAENDIATFASEPDSISGSGSFASNNPFSNASAVASSQVRSPPRRGVSLSDIGPVPGSRGENVRVAQRQFRRQSSNIGAPPSTSRSRQSMQLADPTDSTSGHSSSSGSGGHLPPGAAAPRHSYGAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ77</accession>
    <name>A0A2S5BJ77_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ77"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ77"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="152"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="386" mass="42742" checksum="202AA886A612BE91" modified="2018-07-18" version="1">MAGPVVFTSQRKRKDSLFGEGNDLTIAPNLGFGADMLSQFPAAARKAMPRDARDMMLNPLGGLSTSLAGLGISGLSRGESDCGDCGRSRCPFCRESGTPSTALAPTVFKSGPASLNMRPSLRDPTMKHLDGPVEPSASYLRRVAVPSRVVRGGVMRPLLVLSLDGVLDCRLPYHLSGGYMDVLKRPYLDTFLRYVLNLQLPWAVCFYTSLDKETAEQTLRQLRGPTGGPERDERDGVVGLFARDDMRQGWKGGELEVKDLEVLWAGLMKEENIQWGVENTVVVTDYPGHYKLQPANFVLSPSMKYISNRPAAEDNFLLLMIAVLRDLETESNFAFHIHESKYNTLDFWTSEQPDKLNERNAYLADAVAICADKRITIRALTGNLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZC6</accession>
    <name>A0A2S5AZC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_7103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000171">
        <property type="protein sequence ID" value="POY69896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZC6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY69896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="201" mass="21662" checksum="9716AB763CD9A12B" modified="2018-07-18" version="1">MDAPLDFNRFPFDLVPLAGQDDDDLVQDTVNLFVIETVTRLVADACSYRSLQKSGQIQEGGSSNEGGRAEAERAIAVDAHATPTTPAYARASKGPLASVKDEHRQTKKRKREAFHARTLPVAERKGTFVVGAHGSLRNGFSTFGDRLPACKDSVEVQDVASEPSTPTSKIVASGHASAAVKTALGFARKQASRRSRSRQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZD9</accession>
    <name>A0A2S5AZD9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative Tyrosinase</fullName>
            <ecNumber evidence="14">1.14.18.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_7090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="14"/>
    <dbReference type="EMBL" id="PJQD01000169">
        <property type="protein sequence ID" value="POY69910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZD9"/>
    <dbReference type="STRING" id="741276.A0A2S5AZD9"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY69910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="137" mass="15189" checksum="E3F202B8F3F56E44" modified="2018-07-18" version="1">MDKIAALLPQHAPGNLPYWMLFVSGLAVFNGIQNYLTTSLTRRVYARKPALVNPLQARLFGVWTLMSAAVRIYAAYNLHLKPMYDLALVSYVLALGHFASEAVVYGTAGLQGLAGPLIVASTSLYWMISQYDFYVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZK4</accession>
    <name>A0A2S5AZK4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_7014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZK4"/>
    <dbReference type="STRING" id="741276.A0A2S5AZK4"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="33"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="907"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY69970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="992" mass="106762" checksum="1E88BAE62E5E8EEB" modified="2018-07-18" version="1">MPSLVAVSTSPAALQAPAAVTPKSTAAVDPHADFLSPAFDPNAFAHRVLEQAQLEHATTDTVSSALGRLNYGVQDLSHQLRQLVQANHPSLTLQASSLTALELDLSEVRSGLGDVQQSVKRLNDKVAEPHNKLDDGLRLLERVRRTAQLARRAHRFVVLVRRLNAQMADVTTAARLSATPTTTGDERSERATAEAALTLAELDSLLTDPVPPTTSSASGPETSVSGGPDPDRPKDRDDDTAAGAGSSSLRDLDIVAAQLGTVENARAYVVDKMQASVQRGLETLDQPLLASSLQTAHNLSVLPALVENLLSDLCDKLVADRVAAAFDMAALAKLVGQKASLMLIESVENVRADLVLRLIGSPTPLRPHSHSHSPDPNPGPADQPTNAAAAFVYKSRLRTEPTPATMPTWQSLFWARLERLVDELGSVCIKVYALEKVLKIKRDVETQESFLDEALTVLDNKPSALFWTSLTRALESQTRETARTSSFVQTTLSTSYPRLLRLFQEFFSKIAVHTDTVYTLAQQSPETILTLRAIQPFEALYLARSRNRLGDAVQSAFSLSSAGGGGMSTPGGGGGHGAEATPTANEGLTLARAIVNELDAARFDPLLAKAVAKGSARAVDAFVSRAESLIARDHASTSLLGPLATPSQLHNADLTSALYHLGLPLERALGDHIESVRDLLRPSVERARATYIAIVNPLILAIRREFSALLARMHRTNYAAAASDTDGRTSEDAGAGGAGGASAYMTDLTEKLSLVKDEILGAYRVGELARDWALDLARFIVQTFLLHASLLRVGESGKLRLTNDTTALEFAVTQYLSAHGLALNSMGDQFKAVRAFRPLLFRDLSTLGKPSQTADVPTLILLHHLLARGGLALPHQVRGWTETEYVRWLNEHQEEDRIRLIEEVVEKERAERSERPAEPPAALDDEGDDDVQDRQDPNAAQQQQQKSEAARTALEIVDKVLRRGGRTVGTTDGTGGRTIKVPTAAAPAIGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZN5</accession>
    <name>A0A2S5AZN5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000155">
        <property type="protein sequence ID" value="POY69996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZN5"/>
    <dbReference type="OrthoDB" id="2526605at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY69996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="605" mass="64927" checksum="2EC1C86609C44A13" modified="2018-07-18" version="1">MSLHGILVSRAGISDNEDASGAPGVLLGVGQPYEAALAEARAHFKIPHHSQARCSFVQRVPARGRLFVVAPSAWHAIQAGDELEFLVTYPTASEAGSPLKKPKAVLPSSVPRFVRDDSPPGGPATWVAAQNGAPCITPATPSGTDTDGQVTDSEAEEQPLADRAQQASMYRAASQGFSAASTSGLSRRPSTPPATERDREQTPSPSNRSQEYKVSLQRHLAASRLREQERDPTHYTPMTGSDDARRPVNSAIDATVRPVRSSGETTDSSFLVGLGSDGQIGFVRPSPPPCGGGTSRNATSMQDLKGKGRALDHDEESDEEATGPFLSQVKAELLSSQPIRLPYSPTQRLAPPPSSFKPVLASTCGEPETSGSGADDLAARLPTPGPSSRESSAEAPRISSVTPRKRRLELENASASVSSKRHAGGSRPARTSPAPRHAGPTTQAVANLKHSSGNSPRKSLSARKKDKRDEALARPRAPIPAISRSERFHYWIRLPNWPPAPRNKGPLQAQYVYKQGARDETTLGLVLKHVFAKASEITGWKEVDLKATIYPETEDGSHAETVLWGWDTILTHFASLEEVGMPENGGIIDLDYRPFRACRSYLDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZY5</accession>
    <name>A0A2S5AZY5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000148">
        <property type="protein sequence ID" value="POY70087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZY5"/>
    <dbReference type="STRING" id="741276.A0A2S5AZY5"/>
    <dbReference type="OrthoDB" id="2525851at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="229" mass="24467" checksum="DEFD3646C1EC013A" modified="2018-07-18" version="1">MESAPTPPVPKPERPSARAGSSQTHSRSLSARQPHNGSGGPSVVYRPQNGAASIESTLKALRLSADAEAELDSSIEFILTPPRHPRYSEPLARSTPAFPSDVARPRSISTELPTRDHDSTLLAKCSSNLNPEVAPFLTQSSLGPASAVSLLARFHEIVKEGKDLIGELRLDAKVALADLGLKPIPSLHGSAQLPYARNPSGIDSFYFSIEPEEEAFTASRGLRSARISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B065</accession>
    <name>A0A2S5B065_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Serine O-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B065"/>
    <dbReference type="STRING" id="741276.A0A2S5B065"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="165"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="564" mass="61427" checksum="A84EAE1AB83771B5" modified="2018-07-18" version="1">MASKVASTSQRLAATGRRAAHAAARVRPAVRTAAPLENSDRPLSSPHASLGRSTGSNPALAFPCLDQNEVRTARLLQEREQARWRAFDSPSSSSAASYNILGPGAEPAGAEKDDPEGPEPAYANVVTGYQTYYHRQPFALDYGGHLPEFNLAYETWGSLNADRSNAVLLHTGLSASSHAHSTAANPAEGWWEKFIGPGKALDTDKFFVICTNVLGGCYGSTGPSSLDPSDGKPYATRFPVLSVFDMVRAQFELLSSLGIQKLAASVGSSMGGMQSIAAAHLEPDRVGKVVSISGTARSSPASMAMRYAQRSVLMADPNWKRGFYYEDLPPHTGMKLARQIATITYRSGPEWEQRFGRRRRDLAPSPDSAELGDEHIPSPPVLCPDFLIETYLDHQGELFCLKYDANSLIYISKAMDLFDMSQEALTDLERRRAARDAGQLPPDGACSVPSSSPATKTASATKRRRDKESKPFISSLPSSHAYLPDLTRGLSRLRNHPTLVMGVQSDTLFPIEQQRELAECLKANGNPHVVYYELNQPWGHDTFLLDVVGVSHAVKGFLETDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B099</accession>
    <name>A0A2S5B099_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cytoskeleton organization protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B099"/>
    <dbReference type="STRING" id="741276.A0A2S5B099"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="991" mass="110030" checksum="1F80F198D0027052" modified="2018-07-18" version="1">MQEVTSLVRAFYGSRRSTLSPTDLRSIGPICTAIEAHNPKRALLLCDQLLKRSPAFPSALGLKALALCIASHPLSASARNDIAKVVDTAKMASKGAALDDAEVLMLLTWALRFAGKGDEALDLMAKAVQNNPDNEELANDAFVQYLRIDDCKSAQQIAMKMSKQFQDERYLWWSVLTTILQIRNLNHPQGPLLLSIAERLLASHYANKPGATSYATANEFHIVSRVLELRAQYSNSTEPPSRPNSTAKPSSSSPSLSNPIALPTLPPTEPPRSARRALLDHFASAEADKRCDENLGFEIWRRDVEFDYGSVGGGEWKRLWDRLATGLREKGDTNWHSMLYMIRAACAVASSSATSLEGPSATEAPSPVGIALLEETRQLLRTLSNESPKSKVERGYLLGLLEVARELRIRQWPEADKLDTLVAEYFDRFGTKACCFDDLLPYIDALSPQELASLRSTLSAATDVSLTDIRIATKAINAWKLLRRYAPPGSAGEEHEAALAFTRLYFEALPLGANLPPTELQPADDFALLAGQAWVAAYQTSRSRAYLESALALSEHILQKSKYKYQVRILAINLLRQLGASSISLAHYRIFGVKNVQFDTLSHLILARGSTYAITAPKEAGVVPEAASVMAWYGSGQREAREMSVRTFMNDAFTKVEDFYEFRQHLENSLQQGLATVETLRMSLLSGTLDAEAIETASIRLAKYVELGDDALVDHRDYKTLPNYQSREGQPIWVQSELGPRPDVNWLRILASAYRRFLQPSSADMQGSNVPTSCTEMEQRFVAFSRDAHLALIADLEGAGEREQAALAFFRDQVDKFATLTDDDTMLQWDVLHCAAVSLEVRLSTALELRLRQRTEDYRFQAFVLLEVGIDRRSEEMILQKTPEQVGLCHHATTLLEELTCHLPAQSKHAKRLRAFRNAARDAVKPIGPKLTAYGKRVAKERAKIVAALAHLQQFEPLDENRLTNFAHALVDSRKSSADALGLAFSRKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0D9</accession>
    <name>A0A2S5B0D9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0D9"/>
    <dbReference type="STRING" id="741276.A0A2S5B0D9"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="247" mass="26499" checksum="A8CBBBD9EEE7D501" modified="2018-07-18" version="1">MGSDWDASSDEETKPVAPPVPAVIPKKGRFADEDASDDDVKDSWDVSDDDDDNKPKKPAVVVGSMRNKGATKQKIAQKEQDELRKAEEAERQARENDPAALRAKARAAQLQADMDNAADLFGGATVNDNPLEMECRTKDDFAAFASALADSLIAKHGSSKYFAGFVDDLARALAGPMKSDEVGKVRATMAGLAMDKQKLEKAGGKTGPKGKPTAQMVARGREDLSSFGEVLDDDVAAADFNEDEDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0J3</accession>
    <name>A0A2S5B0J3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methionine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0J3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0J3"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="9">
        <location>
            <begin position="57"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="585" mass="65620" checksum="E78A57F4117163FC" modified="2018-07-18" version="1">MALRALASRLPPELVALTRQHLGPAAAAAVAPRRSFFTSHTVWNEEVSTKTTDNSYYATTPIFYVNADPHIGHLHSTLVADVYTRFARLRDPQPGAEAKGIAPKQLCDNVSERFKDLARAANIDYTYFIRTTEDRHRVAVEHVWRELERRGYIYKSSYSGWYAVSDEAYVPESQVAEVIDEKSGEKSMACTETGTRVEWMQEENYKFRLSSFREQLLRCSVAHRLLCKAAVEVSRANEAFFSRSRSTFVPLNSSPRGARTSPFDGLERPLVSRPTSRLSWGIRVPDNPEHTIYVWIDALVNYLTVAGYPWKGGEEFAQGQVWPPDLQVLAYLGSFHALYLPAILVALDLPLLKHILTHGHWTMGRFKMSKSRGNVANPFEAMEQWGVDAMRMYLMRVGGNSGGDADYSAPEIERLYRKDLAGQMGNLLNRVTTKKLTKKLESADLMHTMPAHLEDADKTLVKLLEDLPAAFEEQLSAFEIHKALAAVFDALAEANRHVQQLSPWLATASPSDVHRALFFGSESLRMAAPFMPTKAAQLLDMLGVPAKRRSWAHRRLGEGGVRTARLPNKAHLWPSIVVAEAAAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0S5</accession>
    <name>A0A2S5B0S5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0S5"/>
    <dbReference type="OrthoDB" id="10612828at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="143" mass="14463" checksum="BA94FC73A5972EA2" modified="2018-07-18" version="1">MGAVCGKEDHFDALERQGKGNKLSGGSTGSKSGAAPTSTTSGGAIRANNASSGPPRSVSTSPPQRLGGAAMGGPATGSSDDSAARREAILAAAEQRANKSASRGTKTGGKLTQQLERQAKDGGRADEARREAERKGNEPLVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B128</accession>
    <name>A0A2S5B128_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B128"/>
    <dbReference type="STRING" id="741276.A0A2S5B128"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000179">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015567140" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="24"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="347" mass="36581" checksum="BF8EC3C617CC6F2B" modified="2018-07-18" version="1">MYWPAPSLFSSSALAVAAASLIAPAEAGYTLQTLYQGESFFEGWTFWGNRDNLTNGAVYYVGANEAARQTVAYTNPAGNVILKADNSSKLATGALRNSVRITTQAAYDIGSLFVMDAYHVPYGCAVWPAFWTHARSWPSGGEQDIFEGVNLASTNQAALHTVVGCTVAGTTTNVTQSGTLTFNDCDYSVAANHGCTYTDARNQSYGQPFGDAGGGIFVAETSSNAISMWFFPRANIPADLRTVNGTPDPSSWGLPWAYYPSSSCNINQYFAPQQITLNIALCGDWAGQPGVFSPSCGTGTCANYVVDPSNFDNAYFEIASVRVYGGGVNTRGSTSSAAGVIGGLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B179</accession>
    <name>A0A2S5B179_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B179"/>
    <dbReference type="STRING" id="741276.A0A2S5B179"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="232"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="680" mass="71857" checksum="7FB4D85BCC073573" modified="2018-07-18" version="1">MPSPGSPAATRGSQPSFLKRKLLSLSSRSRSSETTASIYKRSDNGRGYGQTPAGPDVEGTARGFGALSLATRAYGYVKQKLTSKSPLDLLPKSWKEYIQLYRTGGIDMNDPPLPPRVVAGSDNIPTPYEAGQFAAPYPLNEDLRQDVVNRLDLFGKKSKHERNYSQSTLELSTPMETSLTSSTLATDSGYSASDADSMRGASSAPRRAPSITSTVPGTVEGGGVVDSLENHPAFRKIIGQCRELFSAEIGLLTVLDEDTQMFLASAGVPDGVGNVLPRAASFCGHTILNDDDGMVVLDSAEDWRFAKGLPTAALGVRFYAGSPITAPTLDPNNPTVAIGSLCILDTKPRKEFSAAHRRMLKELARQVSEAIEVWSRDRLTARMAQLETSFVTGSAPRLERHGSSSASALSGAMSARTLGRGSLSSASSLSLASQQQPAAPPPSLPLPPIPPMSPLRPNAASMHSRIAPSAEPPRPRRTSDAMSTISSTTTLDLAGPTSHSTAAAMSRGQSAPAFALSVTTEDPLSSVPRDAQERMDTGTRLLAKALEVELTYLAAIDLAAPPPLSSTSSGSDSGSATGGDSFRILAAHGLPSPAPAFDPALHLKALRAPEGGLVYKNPRHGASASSYSAGILIPVLEVRRTGYVLCAYSQRGEREFSQRDLSYMVKFAQALETACIKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1E5</accession>
    <name>A0A2S5B1E5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1E5"/>
    <dbReference type="STRING" id="741276.A0A2S5B1E5"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="265" mass="28570" checksum="465F96D4DD5386C9" modified="2018-07-18" version="1">MASPRAVSVAIIFALAPTDSDSNSTSLHPHAADSDEEPTFLLVSSRKRKNRYVFPKGGIEYGERPAEAAEREAWEEAGLRQGTAKHLAHLLLLKDPSAHILSPTKDVDSASFVASCQYSFELFFLPPPPNPPASASPSVRTADDRIPNSNGEVQVSGTASSSESSIAAPTNGAAASNHSRLPASDSDPPPVPVSSLPEPYLSTYLSPDWPEAAERDRILVRGWDALQQAVCWGRREDVMRTAIDEARKWIQDEWDPSATLEGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1J5</accession>
    <name>A0A2S5B1J5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1J5"/>
    <dbReference type="STRING" id="741276.A0A2S5B1J5"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="164"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="245" mass="25983" checksum="FF4B06172320ADAF" modified="2018-07-18" version="1">MFQGLTGGLSRVLGYTTAPDSSHTIPSIVAEPETKSIAFPAVGSQQRAGTAAPTPSLSLSLPGADSDDDGEALEDQEEDDDDFVSPGAPRLRVNGSGATASKRNSRPLAPSDGQSGGLLPPPSTVKVVKAPKGRVRVEKGFSQLDWAKLNRTGEVDLTGGIPEPIRVTPSELAKHNTREDCWQVYAGRVYNVGPFLRYHPGGVGEMMRGAGKDATQLFMLAHAWVNYETLLENCLVGFLVPEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2E4</accession>
    <name>A0A2S5B2E4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2E4"/>
    <dbReference type="STRING" id="741276.A0A2S5B2E4"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="569" mass="61744" checksum="E3E5BA9CBACF2F02" modified="2018-07-18" version="1">MSAAIELLNPRADVRRRDAAFQINVTGATGLADVVRSNLGPRGTLKMLVDGAGQLKMTKDGKTLLSEMQIQNPTAALIARTAVAQDEMTGDGTTSVVLLVGELLKQSMRYTQEGVHPRVLADGVEVAKNELTKFLDQFKVAFDAGAKPNHETLVQVAYTSLATKVNQHLAKSLAQSVVDAVLAIRIPTAPASSSASASASELPAFEPIDLHMVELMKMQHMTDSDTRLVKGLVLDHGPRHPDMPKRLENCFILTLNVSLEYEKTEVNSGFFYSSAEQREKLVESERKFTDAKVRKIIELKKLVCDHRLDANGNPVGEVKNFVVINQKGIDPLSLDMLAKQGIMALRRAKRRNMERLQLICGGTAQNSVDDLSPDVLGHAGLVYEHTLGEEKFTFVEEVKDPKSVTLLVKGPNAHTIAQISDAIRDGLRSVKNALEDAALIPGAGSFEVAAHQYLLDETKKTVAKGRAKLGVQAFADALLTIPKTLAVNAGLDVQDAMVALQDEAAEGHVVGLDLTTGEPLDPVTEGIWDNYRVKRHLIHSAAVIASNLLITDEMMRAGRSSLKNEEGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2N8</accession>
    <name>A0A2S5B2N8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2N8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2N8"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="249" mass="27432" checksum="E2B70944E84470FB" modified="2018-07-18" version="1">MNIIDSLFGRTKTPAERLRQHQRALQKAQRELDRERSKLEQQEKKLILDIKNGARKGEIGSCKVMAKDLVRTRRYVSKFYTMKTQLQAVSLRIQGMRSNQQMAEAMKGATRAMSLMSRQMNLPQIQRILQEFERESSVMDMKEEMMGESIDDAMEDDVGETEEEEGDRILDEVLAEIGVSVGQQLGEAPSSMPASKVSEPGVRRAVAIGESAGPAPASSSGTSGLGGSGGGDDGGIDDLQARLDNLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2U1</accession>
    <name>A0A2S5B2U1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2U1"/>
    <dbReference type="OrthoDB" id="2525787at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="336" mass="35366" checksum="E15AA941C372A509" modified="2018-07-18" version="1">MPRRLGRATPIPSPLLAVVLVASWAALWSPARVGALSLFDAFSHSRTTTAAKQIAPGVSPAGTEWWCRTEGECLPCPPGAGHTTQRNSDVCKIYGNRRPLICVPRHNANLASAASSPSDPDSPPPSNQLDDFAGAGSGDRTHHAQGEPAPAAAAAAAGAGANAKENRVAPKPLVAPAGSRAEADSFAREDEETFGTGNQGAIGQGGTGGGAAGLGGNEDAESEAGLRQSGSTKADQELADELQAERRRRRRWHADADDLQADRMLRALLERSTGAISTWEACPKVLHSEYHDYFEFILCNAGFAAAAMVILIFRQRTLALQQFARLAARIMQTQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3A2</accession>
    <name>A0A2S5B3A2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_5548</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3A2"/>
    <dbReference type="STRING" id="741276.A0A2S5B3A2"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="398"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="32"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="634"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="913"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="919"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY71236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="949" mass="100922" checksum="07E88C8F857C8ECD" modified="2018-07-18" version="1">MLPRSTTASRATVAAQSLRRHSLLTSSRLVAAAGTSTPCPSSRHRRPLSIASWLPTTLRATPPQSGESKHPEPKDGERPPGLDDFFGGFLGRRPTGNRKDNAFPGGGAAPPVPGAAELAPKDPLKGLFGQQAGDTTGGPGPDKNKRDGKDGGKNNANKKRDSKKGGVPPEETPQPPSPSASTVLATAVAMYVLYRLSSQYDPSSREITWSEFYSAFLSKGLVDKLTVVNKSRVRVSLHSNATGSPAGAAPGQGAYYFSIGSVEAFERRLEEAQTELGIPLGERLPVAYHDEIPLGQTVLNLLPTLLLIGSTVWIYRRMTGGGGAGGLLGGGGGGPGGGGGPGGIFGVGKSRAKMFNHETDIKVGFRDVAGMDEAKEEIMEFVKFLKNPEHYERLGAKIPRGAILSGPPGTGKTLLAKATAGEAGVPFLSVSGSEFVEMFVGVGASRVRDLFAQAKKNAPAIVFIDEIDAIGKARGKGGQFGGNDERESTLNQLLVEMDGFGTGEHVVLLAGTNRADVLDPALMRPGRFDRHIAVSNPDVSGRRQIFNVHLRKLVLDVPKEELEKARKGKDAEAESASEEDGGVTEGQQLAVAHFTATPDPSLSPSNVNATGTAAAASTIDIASSPVLSSLLRATPANEASSTESSSGEDKPKKSNFESMYTLKPTDEVDPNSVYGRLIHKLAAHTPGFSGADIANVCNEAALIAARLGANMVTEKHFEMAIERVIAGMERKSRVLDKEEKKTVAYHEAGHAVSGWNLEFADPLLKYLYSTEQLIDRMIMTLGGRVAEEIFFGRITTGAQDDLQKVTRMATEVVATYGLNSAVGPLSYRQDQESFQKPFSEKTAQLIDDEVRKMVWEAHKRCKDLLTEHRAQVEKVAQRLLEREVLTRDDMIELIGKRPYGDNYDEVMSLGAATPNPTDGGLGKGVEGGLGGGLGNPIPEPKGIEEGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3H9</accession>
    <name>A0A2S5B3H9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3H9"/>
    <dbReference type="STRING" id="741276.A0A2S5B3H9"/>
    <dbReference type="OrthoDB" id="2536659at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="832" mass="85304" checksum="13559E6480903B3F" modified="2018-07-18" version="1">MDAAPPSYSQDGTSQIPLPCPPVLINLAPATSGADDAADSDLEATTFQVGDLGTGRAYVAGEVQLKFTRAEPDVQYDRLEVSFHGVETVGDASGHTAAAGPSGSARHITLVDRKATLWQAGWNATDDATPRGSREQPPASSPFRFELTSDLPTCIHLGTSSLTYTLTATLYPAAESSAAPVTRAVPVHLVRTAAPAALVPARPATVTASDPTSWRVRFPRTTFTRREPIGLVVRVDVPDSKRIGEGLRLRTVSAELVRTITAAAPTGAAPAEPSSSAGATTRAGPVAQESRRTVLAHSGKSARFSPSRPIIIRLVLHPPVEPTCESISQSTILHDVSFAVIATVGLVKTGSDSTSSTSTSTTPSGPLPCDSVLSHAITILPDLPAATPQLRSDKQKEVEHAAVSVAASSLVTAGAAPGSVSRNWDEEHPDAPVPSYVENSLLDPGTADSPAAASASPTASTSATWPSGSSALPSPSLQADPTDAILSGYALTSSFGDGDDEALDAEEEYDGYEELSLPASLSDRPPPPTIDDDISPPSAGEPSSAAGFRLASVSGGVIDADGGQRALDSGDGGATAASRSSRDFQGITAAPLTSGRTSLGEPETPLPPAEYSLPFLPAPSAGEPAPYGMPPSALASQTATIAVPAYADTSSAVPSSPPPPLSPLTADHVPLPPFSVSTPSQSDEQAPTAQQPRQTRAGSDSLPPPYAGRETLARSPPAPREVALPELRPSPAAQPSAARGPLQGAESIDSPPPAFGTTLAGQPSRSPTTAASSRALRVVEESASESHAAEPTGREADDESRPPPYEQRDDGASGPSGIQWGMTQNRRGELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3N9</accession>
    <name>A0A2S5B3N9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3N9"/>
    <dbReference type="STRING" id="741276.A0A2S5B3N9"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="241" mass="26866" checksum="FCABA127A43A870C" modified="2018-07-18" version="1">MVNEMKEVAKLGVELTVEERNLLSVSYKNVIGARRASWRIISSIEQKEEAKGNSSQVEKIKAYREKVEKELSDVCNDILSVLDQHLIPAAQSGESKVFYHKMKGDYHRYLAEFAAGEQREKSSEAAHESYKQASEIAQSDLAPTHPIRLGLALNFSVFYYEILNSPEKACHLAKMAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDLSAEEPKAEDVKPEEAAAPAAQPAGEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3P1</accession>
    <name>A0A2S5B3P1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3P1"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="56862" checksum="326C123898D8A29C" modified="2018-07-18" version="1">MQRRTRRIRPFDVALRAYVLGYAIQTLPAVARVVIAWFSRNTRSLLPALSRGVRIKSLATAFALAFGGARLLEPLANRLVRSCLPSPPGDDEEARSARERRSRAISTFCSALTTSLAAIVLLQARQSLVSQSIDFAVTPYAAPAAVEASAAPAELTPTDSSTLDLTLLIFVRAGKSGSEPLKPPDPMLTPEPPVDACLRFLHDTRPPKAGRSATVRRVFAEYGDAIVFWCASWQIMRCWFNKPHLLPKAYSKWIMRLSRMDPNVLQLLRFAREKRFVYGSEADPEVLRVCRSAAARARLSPSALDPSRISRIDCSLVHASIGAKSCHGNAVQRWLRAFLDAFAIYLPVHAVPLLLFRTRRLWRHPRSGIFQILEGASRSSAFLATFVASIYTAVCLVRTQLPRAIPGIPQQRLDGGSAVQAGCLVCGLSILLENKHRRKEMALYTAPRALYCLLDEVVPAAWLSTQLGRRIGTWTERLVFSASSATVITAAVHRPALVSGVVRGVTSFAVGDWSQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3Z7</accession>
    <name>A0A2S5B3Z7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5826</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3Z7"/>
    <dbReference type="STRING" id="741276.A0A2S5B3Z7"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="13">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="256" mass="28275" checksum="6E75457002658441" modified="2018-07-18" version="1">MTATSLNSSGTAPALPADCQEGVLGFFHTLERLKTNKRTGWVNQGVQKAESIADHMYRMAMMCLAFPETQSLDISKCVMLSIVHDLAEADVGDITPEHASGVSKAAKLALEERAMERIYGLLGHPSMASLRLKSLWDEYEARETAESKFVKDLDLYELCVQAVEYENSQGARNLQEFFETTLPRILHPVVVGWAQQLMTQRRERWAERGWTDYKEVQIGAVPAVNGHSGASEAHKGPSIPVRVYGEHADDAAAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B494</accession>
    <name>A0A2S5B494_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000076">
        <property type="protein sequence ID" value="POY71603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B494"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="188" mass="21608" checksum="04805496C4592655" modified="2018-07-18" version="1">MDDPSWRTILAWDITEPSERGRFPVWHDDILPVLEDTLARFWSNSAAHNAVKSHLEHEQTVFHPWYSGLAQERDGLDPAKPGDTARRNETKKLVRLYLACIRKRLETVVAIINSRGIDAAKDFVLYCTPRVICYRLQLCRPSFPFPPAIVGTPTNSLAVHPQLHQITNRAAYIYGHESPEVWRRAIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4C7</accession>
    <name>A0A2S5B4C7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4C7"/>
    <dbReference type="STRING" id="741276.A0A2S5B4C7"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23285" checksum="D3432CFEABC0DFE5" modified="2018-07-18" version="1">MATRRKVLLKVIILGDSGVGKTSLMNQHVNKRFSNQYKATIGADFLTKEVMVDDRLVTMQLWDTAGQERFQSLGVAFYRGADCCVLVFDVNSAKSFETLDSWRDEFLIQASPRDPENFPFIVLGNKIDMDESKRMVSQKRALTWCQQKGNIPYFETSAKEATNVEEAFKAACRNALQQEGNADILDDYPDPIRINAASEGNSYGCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4E6</accession>
    <name>A0A2S5B4E6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4E6"/>
    <dbReference type="STRING" id="741276.A0A2S5B4E6"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="210" mass="24103" checksum="400A24BCB659C3A8" modified="2018-07-18" version="1">MADEIERETARLFRVSRTAHELVRDRGYAIAKEEIEMPLDEFKAQYAPGGTAIDKAKINFSAAREADSAEQIYVFYAEETSVGIKTMRKFIDILESQKFPRGILIYKTSMTPSANKVITAMAQQFTIEAFQESELLVNITQHVLVPRHEVLSPEDKKTLLTRYRLKDTQLPRIQLHDPVARYYGLKRGQVVKITRPSETAGRYVSYRLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4I2</accession>
    <name>A0A2S5B4I2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4I2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4I2"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="316" mass="34613" checksum="93A5A6556EECC7AC" modified="2018-07-18" version="1">MKNKRIKSYRRAMQLYQSSFGFREPYQLLADADFVQSCVTQKMDVMARLHDVLQGAVKPMITQCCIQALYDAGEEAKDAVEAAKGFERRKCNHFKARKQDECMLAMAGEQNKNRYVFATQSLPLRESLRAVPGSPIVYIARSVMLLEAPSNQTLAKKRRMEESKLHVSAEELAQITGKPVPTPTPKTDEAAFADNAGPAGTSEPPQKKKKQRGPSGPNPLSAKKKSKPKSGDDNAGRRPSKRELEGQQSGEAEAREERAAKRKRDEEVKVVSLAVRNGVDTNGDRKKRKRRRKGGAGATEGADGAEAGAGDAGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Q1</accession>
    <name>A0A2S5B4Q1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Q1"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Q1"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="167"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="491" mass="53973" checksum="5912E9BBBB07DB82" modified="2018-07-18" version="1">MASMARSYLGAIYLGTMLNNILIGMLLVQAIGFFRHDFQGCRSTTKLMVIAILVLSLVQTAFEVFLVWSYNVDQKPVPSDLNQFSWSLNLMPLLTACTVTLVQSHYITVLYRITGRAVWLAAITAILTAAQLAFALFVTVCAFNEDLWQANITKVRPALATWLFLCAGADVLITSGITYSLRRIQVDFARTNDLIGRLVQLTLANNGLTAICAVATAVSFVAADGLWWAVAGFALPRLYANSYISSVTARRRLVESRSQQSPKPLYQQAEKPGPLRRLRAALPGRRSQAPDPERGAKVGHGPLRIAVQTEKVEHSERHVESRQLGDSALNCPRVASPGPIRQAPTTTLSCSDESYLGQSGGHVTFNSATSPTNKVDSDGTLGSGSRPRQQDNPAEVLSRLARDSCRKASFLRAVRCKDSNKAIVLEALRRAQYKFPGQKIIISKKWGFTNLSRAEYLEKRSIAQPDGAYVQFVNPHGPLLDNLKRLERIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4V8</accession>
    <name>A0A2S5B4V8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4V8"/>
    <dbReference type="STRING" id="741276.A0A2S5B4V8"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="10">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="526"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="443"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="526"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1054"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1068" mass="113361" checksum="F5B754E5877DBA58" modified="2018-07-18" version="1">MPPRFFSSPFKNAAATPAKREGWWSEIPVAASAPSDSADAIKATADYWLALGAGSGSLVVLPYDHQGKQGSKAPTFQTGIRTITAFDADSFDQLIAVGGDGGQCTVLRAVSETEPPSPEEINVFALPASSTFDPANPTFYSPTSLLSVNLTTGKAVDTVAFHPLASSVFLASSQSTISVFDAASQGAEAAYTLSAPSASWSAQWSSDGRSITATGKDGKLRLWDVRSGNSAPVLETATHAGIKASRHLHLASSAGPQVFTTGFSRTRDREYSLQDFRSLGNGSVKTQRVDTGTGVLVPLLDESRNIVYLAGKGDMTLRWTEIGGPSGFTEGAAPLPVPIVSAALVPPNNLDLMKAEVNRLVVLAGGGNDAVLPVSINVPRRQYLDFHADLYPAVAARQAEQTSAEWMRGEDANGLAKHTPNPNSPWPTRQAKGASSTPANGQSSSPSPGPVGSSEPSTGTGAVASPAAALAPTATTRAPEQAPAGEPGPTSARSETQSEISSRSTAETTPPREQLAGLRLEATTATPEPAAKPAVSPAPSAAATSAAPATNTARFFSSKSSSPQHSAPAPTTRSDGLFNPKWSRNFLAGKTPLKPDYFDVHDVSSTMGNDVQLLQATPLYFFFPLGGPGGRLTFHALSRKGRLPVHPSCVAIGGTITQFETDPFNPGRVFVAGDDGAIRVFNLPNEAPDDGTTISEAAHTLSDGKMDRVVELRHHPTASDLLLSLSDDRGKPTGRLWNVETGELVRTFELPKGGISSASWSPDGSLLGLATKNKQLHVFDPRDPAATLRSSASHESIRPVRLAWAAERRLMTTGFNRAASRELMLHAVDDSTLSQIGKISLDISPAALFPFVDLDTRIALLYSRGDRSCLAFEIDLDPKAPQQAFTKLPSFEHRSLQVGFAFLPKAMNDVKAVEIVRALRLTQKEVEVVSFSVPRAKVRPLQYGCLENLPEQSHFSPQVDFFQNDIFIPTRDVGKPTLTAADWLAGKNAAPSLLDLRPSGMKLLSDAPAPARTVNTRSKIKQDGMTDSQREKAHLDDLFDSAKAGAASDEEEVEPVRSKHAIVDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Y3</accession>
    <name>A0A2S5B4Y3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5201</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Y3"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Y3"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="346"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="378"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="461"/>
            <end position="463"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="473" mass="51817" checksum="93C9CD0F6DBE6C7C" modified="2018-07-18" version="1">MASTTPPNQVEVVLGAQWGDLFAELNPRRTAELMPKLVFAVVPGKQEGKSNLLSAPHWLSEGKGKLVDILAGEVDICARCAGGNNAGHTIVATIDGKKTKFDFHLLPSGLVNPNCTAFIGNGVVVHIPAFFQELDTLISKGLNCDGRLFVSDRAHLVFDFHQIVDGLKEVELGGSNIGTTRKGIGPAYSSKSSRSGLRVHHLFDEEAFATKFRKLVEGRFKRYGQFEYDTEGEILRYKELAKRLKPFVVDGVSFMHDALAQNKRILVEGANALMLDLDFGTYPFVTSSATGIGGVCTGLGLPPKAIGETYGVIKAYTTRVGSGPFPTEQLNKIGEHLQEVGAEFGVTTGRRRRCGWLDLVVMKYSTLINGYTALNLTKLDVLDDLEEIQVATAYYLDGKPLPALFPADLDVLARVEVKYETLPGWKQSIQDVTKFEDLPKTCQEYVLFIEKFLGVPVKFIGTGPARESMIVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5G8</accession>
    <name>A0A2S5B5G8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000062">
        <property type="protein sequence ID" value="POY72023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5G8"/>
    <dbReference type="STRING" id="741276.A0A2S5B5G8"/>
    <dbReference type="OrthoDB" id="2526787at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="831" mass="90035" checksum="EA8A1DA49BE7F459" modified="2018-07-18" version="1">MLVVRVLPPSGNPNNLFPYQGIWGLEPVWVCGKIGCTYDERASGKPPKVKSVQCRLVRVEAIRGKTTRERLAQATIWTPPDGQEACEVGQVEIPFEMPIPDDVVGMSSMTMFPTARVSYQVEASATLANGRNVTAENRTMHVVRFNKMSMDPSSTGPIRWSSETNFDQVVPFEYSIRIPNVLLTPEEYIPVYISMSVPKDATAPVHFKGYELSTKRQVYLVSNGQPSGPIETTSFQYESEILAARTERPSTRSRAAAARRAAALAAEPPPVKMQIETDPPGIPLFDKDSFPMVLQPGESRIGMARLRMRERGFHAWSYGETGQNAVFRIQFFLAFKFFIKKGRSTESVKFKWRPITLCPAEDFPAQPRPLLVQSPSRESLGSYEEFEPTWPDVAPVKRPNGERSAFDATSYLTAGRSYREGKEPEYSYRSRRGAEASEASGAPARSKPRREPPNSLATRKHARGRRLETTPIDEIETTSRPPSPGPSVAPSSMYSSQYAASQVSAQYPSKFIRATQRQQAQSIISGAPSTFGSSSGTSVSNVSMMSYGTGSSSSGQSGVDSRRPRRLYRSASLTALAGMSMSTFATESSSGLSSLDAMPDLRIEEETQAAQIDEMPEADREQETLATVDGVTPRSHLASLAPLDPSVTAPVSPLDPTSSLPALGKLEEPVFRDPFAGILTPHGTLIKSSIPSPPVASSLPPMTKKEIKEAQKRRLELAAALALVQPGHIEKHASFGGVGGGDAPLAPATTSSSPTLAEPLPASAVATPPVAPSLASVSVRRMSMAQQSVRTSSMERRDSDSPSASFTSTRKSSVGTLLASIFSRRSSCKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5J2</accession>
    <name>A0A2S5B5J2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione S-transferase kappa 1</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GST class-kappa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_4919</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5J2"/>
    <dbReference type="STRING" id="741276.A0A2S5B5J2"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015672664" description="Glutathione S-transferase kappa 1" evidence="12">
        <location>
            <begin position="21"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="13">
        <location>
            <begin position="850"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="726"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY72049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119432" checksum="27FDC8D8B31DD272" modified="2018-07-18" version="1">MQLPRLALAALLWLCSLVTASTLSHGQVPFLSPEQLAAASTTAEKHEYQSDIARLMRVVVSHLYNDRDVFVRELLSNANDALEKVRLVSLTDSSIFTPAPSLNVSVIADADGGRIVIRDTGIGMTKDQLEENLGTIARSGTSEFLETIESKNAEGANLIGQFGLGFYSSFLVADRVTVASKTATDSEQWIFESQADDDGFRIVKDPRGATLGRGTEITLYLKDDAKAEYLNVDKLRSLIQKHAEYNSAPIFLWTASSTAAPVVEVTPKEDKAEGDEGEVEVEEDKDAEPVVEAPKWELVNDRPPLWMRDPKQVTEDEYEDFYKKTFKSTEGPLAWSHFKGDAGSTAFRALIYIPSGVPNDFYTKDYVSLESLKLFVKRVFITNDLGPNYLDRHLNWIKVFIDVDDLPLNVGRDSLQKTRALSQIKRNLTKRIYDLFAQLARDDAEKFDELYKAAGTSLKVGAIDDAKNRDRIVRLLRFESSAVNGTTNLDDVVSRRKQGQTQIYFIAGAGAKKEELAQSPFVERILARGYEVLYLTEPVDEMLINNVPTYGGLRFQDVAKEGVTFGDEDEDEKAEDEHLTKQFEPLVAYLKTALAQVVDKITVSHRLTTSPCVVTAGAYGYSGNMERLIAAQNAGQGQDNFMLEFAKMQKKNFEINPRHPLIERLLEKVEEAGNDEDAQEELSESITVLWQTALLKSQYQVPDPNAYFAMIESMLRRSLGVSQTAKADVDVKPAPPVETGPPPSEPPPPPAFDLEAEAEEQGDAAAAAAAAAAAGKKDSWVDWKEVRHTIKDGVIDIAKAAIPDYDTDEPAEGAASTFVFFGRAEKKSSPHRFASLASQTQRDIMTKATLYYDIVSPWSFLAYTVLKRYRQPWDMQLELKPMFLGGVMQASGNKPPITVKNKGLWMNGADLPLAFDWMKIDFTFPQSFPVNTINMMRALRAIQQIAPEKLEKATDAFYSAFWQPPSSGPSATEAVKPAAFPAILQKNGLFSEAEVKQIASAMESDEIKTLVKEESGKLVAEGGAFGFPWIVVKRDDGKERSFFGADRFEQMSYWLGKEWKGPLGDTSKRPFPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5K9</accession>
    <name>A0A2S5B5K9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5K9"/>
    <dbReference type="STRING" id="741276.A0A2S5B5K9"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="153"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="377"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="89325" checksum="0EAD08F61FD8B357" modified="2018-07-18" version="1">MDPIFLSHVAVRLRDSLAPHRAVPAALVLSTLQDILQQRVRAEEAERLAVEAARSLQDALFLHDLDWKGVPIRPEADPSVLYAFSSSYDELPTGILTASGNCYSPLCQLLASQGHPSGCYAFACPRRSLAGHEQPVRMPTELKAVESAPLVDALAHQVRELFEGEQAYYDDLCLVETAFVQPLRTAVPPIITPSRLENFLDDILLNFAEIREHSRRFLASLGALEGTAASISDISRVVATAAESWAPVYLRYTTAFPLADSLLRREKSTNSAFSALLEHFHNHPLAARRGFDTFHSRPTFRALRYKLMLEAILRSSSPSDAGRPELLRTIDMLGQQSSDADLGVGKAKRAMAVRDLRKRLRLKDDTELDLHITSATCLEKEGPVHLRDSTGSWRPAHLFLLDNFLVVAKAPRVERDGRKRFTVKRRPIPLDLLQVLPQTPPERAEGLARELSRHQNVTLVSASQPARLHAVRCQVVGPRRQSLDFYADSRDDADNWRMRLQQAISARQDRQGVHLDTLLPADARDSRLAARIRLAAHPDLLVTGGLDGFYVGWTDIPHSHRRVAHLPRIEQLETHTPGRTLFVLAAGVLLAYPFDAFIPTVSLDMSLPQQKPCLPLRISGRETVTRFALRRDGKKVLLASLQLGTIPSFALSTFHEGLQPHPQRYAIQQRSPCLSKATTVPNLLPISPSAAASFARYTEFSTVLALLQRSPESHLLVCDDIVSVIGLHGEPTVPPLFRWYLKPHYAVMLGDLLVGAGPQGFEARSAFSGALMFLTALPFCGLGTFEDGGVYAVAPDGTQQEVSVVVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5R6</accession>
    <name>A0A2S5B5R6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5R6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41120" checksum="ED883DFBAE0B9DAC" modified="2018-07-18" version="1">MAANALAAALARAPTSPSSLAAAACRRCWTILKPLRWKVLAIDTSTADFARLNIFLVETGRHVARLHLTFDARNVHRVDQLAPCLRLLSSIVHFKLLVITSQRGTDVPAQRLTEIYQALRERSTRLETLELRASDDSIDFLAPGLTELLRQNTSLRAVKVFMQQSLADRLMVRDNFCAALADLTEIRVVHLETAVLSGLGQCRPQWPFLSYAAFEFGFENSAVELDLILYSSRDSLRAIVISEFSRNVRGAEASGPLHFHQLETAVVTTTEAFSLFRQLVHVSSPVHDLYITEVTPESVQAVKAFYDDKPTKTLTRLVVPTGLSVLAVIDEDSFWALCDWAGPREIEVIQADEDAFCDALQRRAWQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5W9</accession>
    <name>A0A2S5B5W9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5W9"/>
    <dbReference type="STRING" id="741276.A0A2S5B5W9"/>
    <dbReference type="OrthoDB" id="2537453at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="732" mass="77352" checksum="C938D680743B675E" modified="2018-07-18" version="1">MDPFSYHPPGLSPGSYAPQQPQPSPTETTGRFQPDMYARPGSSGGGTPVSAGFTATLPPLHEQPSNESVPGVNGAHAALQYGNGQSGVPRAGSSAGRKRSADVYGRTASRQGGDFRDSYSTTQSHHLDPNRSADLNDSLDFGFRDPFVRTPSAGASTDPASSYNVFGFNPPPLENPTHSAGAHHYGYFNPQTVHPSVNTRNTRPMTAPSGSGYMSGHSYSSAPSAFYVPHHQQAPLIGGTDSPLGYDVGAVEAQQVFAFQPDLSTPQAEYEAAQRNRNFSVPDALSTATLDDRPFTADAELLSASAASNPFMYQPPPSLVHVDRAGRPYANGAQGFVPVSVVDPFAAGLMQVPTPMQPVPPGSADGFAPAVEGSASRRRSSSGSNKYGFVPQQPQHTKRPRRRYDEIERMYNCDYPGCTKSYGTLNHLNSHKTMQKHGPKATPAQFKEMRKAWRERKKAEAAETARSQAKEPFAPAANMAFPLSALPAAAIAPYPVASVDRPRPSTSAGEYSYGMPTHLLTPVSFPPPPVLASANGAHLTGVPPGFTAVGAAPSIYLDVSPYASYEGFDNASALRPVTAPAYHQAPPFGGVAAAQLGQAPHYQPGLSQSLSSASVRPELSSRTPSGGEISFDQRRFSLPGSMLPAAANNKSSQMLPPASVSRSSLSSSQPRQAIPMRPVATPEMKMPQPVHAPSSYANLIGGATPGDSPDPGRHYAGRENGNSPRVNEVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B675</accession>
    <name>A0A2S5B675_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B675"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="47512" checksum="9887C480E713C519" modified="2018-07-18" version="1">MPASFDSLPDELIDVVFDRLAARLDEEALDRHNELIQLARVCKRWTPLVLPRAWEIVKIDSLLAPSAQIRHLLARPQLLAYVRKVYQDKDSRLESLVSLTSTEHCTHAPEIVELLRLCPSLSRIDICIVEPEQDVLSAIAESPSARHIKRLTLTAVMKTAGSIARFLHCLAKLHSLTSLDFTWASPPTAYRALEEAFAGEKLKVEFLHLQPLLGEGEEPAVMLRFLDAVLDSAALHSISLSGWKGCSDFFHAAATHHNLKALVLGIDQLDAEPAQLGTSLLALAKLSSVTDLFLHLYGGTETGLKCPIHLGALLESMPTSLQVAFLNCLVVNREEANGIPELELELDSTRVVPVHGLVFLQVAPIAEEVQEQTQSKVTFARVKVEDDFAWRRLPSGRRNAHRTVDAADQTAAPSESKAGTGETGQPGEATASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6C3</accession>
    <name>A0A2S5B6C3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6C3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="226" mass="22907" checksum="BC7E4862C13339A7" modified="2018-07-18" version="1">MSGGQQHKWGRPKQATVGPTATLSLEQQQILAAVPRYKKAWVRPASLKPGQNPNFKILKWVIDTDQDKSAGTEEEMREALEQVTAGNVPLPSEQDQGVAQADPSTAADASSAPTSAVPSAAATGPVPTPSIGTPATGTPAPADATSAQAAIPSTELAHASNPIAQAQGNDPAKPAEGPAPGGEAISVQEAVKGLGEVEMHAAVDAGPSVPDEAKSLVQEDQVAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6D8</accession>
    <name>A0A2S5B6D8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asparagine synthetase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6D8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6D8"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="5">
        <location>
            <begin position="451"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="611" mass="67337" checksum="DDB09F8F007019AD" modified="2018-07-18" version="1">MCGIAFSLEVIDAARDSSQTDAIWQSYTDAVRSRGPDASDSFIRRLENSSGSQLQLRFHGSVLHMRGDQVTPQPLVAENGDVLLWNGEVFDGLEIGEHENDGRKLLDRIEQLGPANFLEAIAPVEGPYAFVYFAASTGILYYGRDPLGRRSLLHRSDQGSSTFALVSNAPIGNAGPQDWTEVDCAAIHSLKLGDWPAAPESRSFVYPFDRLNPALPRLGDAVPMTRMLPPGPVIGPKLMDVVHTFLAELERAVRARVATVPPFPPPPAARIAVLFSGGIDCTVVAAVLDRVLPQSESIDLVNVAFENPRSLNAREFAQQHPPKPSRRGIRGPRWKTGDSEVPASTEPISTDTEQSSAPLGPYDVPDRLTAREAWQELRTLRPDRQWNLVEVDVPYQEMLEHRQRVVDLMKPQNTVMDLSISLAFYFAARGQGHLATAGPDQQEPPEYTSRARVLLSGLGADEVLGGYARHRRAFSQPVAPAVNGGTDEQPVPGPPVNQNWQALLAELQMDLDRLPTRNLGRDDRIISTHGKEARYPLLAGHVVDFLARQPVWYKADMRFEEGVGDKMLLRILARELGLREAGRRKKRAIHFGARTAKMDLGDGKAKGTDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6M2</accession>
    <name>A0A2S5B6M2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000049">
        <property type="protein sequence ID" value="POY72416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6M2"/>
    <dbReference type="STRING" id="741276.A0A2S5B6M2"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="2">
        <location>
            <begin position="58"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="510" mass="55796" checksum="ADA87D3BC05847F7" modified="2018-07-18" version="1">MATSRPKIPPRPPARPKKPSRERSEPLPPPPPPPLHRRILFLPSSQTPSPRILHSAAHDSLDPLILDLIALTLRAYVLPWYNGAISRDPDKDFLQACTNVLVHVVQALEVRLAAFDWATLVLDEVPTVLAEHYRDWDLAQEKAASGSTLHNLSLGELFDRIHPHLAVHVVTADDLAAAPPPPPQTPTSSPKASPPIEARVDPTYLRALTDHLLRLLLPPEDYRSTTERAIIREVLVGVVFRTVFDRVAQPWFVHALIAKQLEARKLDEAARTILRMPPAESKGRSPWLERAGRTFWTVTDLALSVPSRIATWIAAPSSLSPSSSSSSSTLAPASQSSAASIPSSLLDLVSSILPQSLFLSQLLTLVSLPLSYLSPRISARLASTVQSRLANAATARLVLEALKRGLFPLEGGWPAPKEPDPDQVERKEWQRRAEAAVAESLPEWLPTVLCPGNLNSNGSTDHRLLLARHLLRPFNSHTANVHLLVLILDLVVGKLAPELISGEGFAADVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B799</accession>
    <name>A0A2S5B799_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein OS-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4429</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B799"/>
    <dbReference type="STRING" id="741276.A0A2S5B799"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015453540" description="Protein OS-9 homolog" evidence="9">
        <location>
            <begin position="22"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="125"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="601" mass="66375" checksum="9CCCA838BBE179DC" modified="2018-07-18" version="1">MARWTTAKVLWLLTVVHQTLALSAHSPRDLEAFPSYSVILSQNPVLNETAIEILAEEATLRNNARSPKRHLLRSPSGQAFLCTVPVIEEERQVVEDQAEKDALVQATEREQGLVNGLALLEPLRNGCLYLHEGWFTYSFCYGAEIRQFHAIRVAGAIGPAEDPESDAYSLGVMPDAQVVVQTPKYGSGSAAALRQERIPARLGAEASQGLGWDEGGRYLSQTWASGTVCDKTGLPREVEVQFHCSTQSTDRIAWIRETSICRYVMLIHTPRLCGEPVFLEGRRTDASTAAAIECQPVVRELPKEGELEEPAAPAAGHDSASGSTVTPQGNDGPQRYLEGAGEQLPQQAGEQEQHNYDLPDLPEHSNFDAELDHDQYHDDQEVFYDEEETMLTLVYDPETGEIESAVTETGEDVFLDSALRKLLFGGEDEHGEHVTAGADASEEAHVEIGGDLANLRQIIHDSISDALRHYAHGQQAEGPADAQPRQAEQPAREPPLLHQPLDDVVQALLAAVRDPQEAPAAAREQQAVADQPPAHSRPNLQPGLHKYLQQFDRARQTVQVPQKAVLGNDEHEQMKRRFARRYEAAADDEQEEEPSRVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7E0</accession>
    <name>A0A2S5B7E0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7E0"/>
    <dbReference type="STRING" id="741276.A0A2S5B7E0"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="72"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="400" mass="42170" checksum="7F933069814B2125" modified="2018-07-18" version="1">MMQNLAAWMQKAGAQIEVAQAPAWTPEKGEVLVKVRRCERSLTPLFPAAFYVTDPTRRKVHSVSVQPVDWKGRRFRSSPRSDSRESHSRLRSLQIQDYGYFVKSYPFVLGSDVAGEVVQVGEGVNNLKDGDRVLGFSKALATGDSRHASFQKFSVVDALLTSQIPDSVSFNEAAVLPLALATAATSLYQSKHLDLPLPSADSPNRAGKGKVILVYGGSSSVGSAAIQLAAASGVAVVTTCSPANFDLVKSLGAAAAIDYRSDSAVQDAVKAIESAGTDFVGVCDAISEASTVERCAEIASKAFDGKGKLYIATTQPRPEKLEGGVQAGGVFALDVLTVDDAKVAKSIYLDFSPLALANGTLRAKPDPLVVGKGLGSIQEGINVQRKGVSAKKVVISDIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7G4</accession>
    <name>A0A2S5B7G4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7G4"/>
    <dbReference type="STRING" id="741276.A0A2S5B7G4"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="94"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="328" mass="36550" checksum="D4A08C1028C0A358" modified="2018-07-18" version="1">MSWIESRALEPYPALVALARPLGDRLGFTALPQVAHLAVSSCIVSFGLQKLSAAVSPRVFGKYYPTNRVKKDDWDLHMVCPFPASRAKHSTTALLTVGRTYTQVGWAYAFVAAPIAIYLLRHPSPALTADPLYGVALPEQRLSAIAIGYFIWDAFVTARHIGTQGIGFFLHGAVCLTAFLFTLRPFVLWCGPSFLVFLNAHWLFDKLHMTGSIGQMVNGLFLVLSYIVVRLGFGTFNSYKLIKLLVPSASNSSLNALRVREVGAIRWMYLALNIMANSLNFYWFRLMLLALKKRFVPSPNSRQAEKTRGKPIPVDGKIQNQDQRVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7M1</accession>
    <name>A0A2S5B7M1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7M1"/>
    <dbReference type="STRING" id="741276.A0A2S5B7M1"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015429937" evidence="1">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="227" mass="25105" checksum="ECE81F47A757D883" modified="2018-07-18" version="1">MVRITWLALAAACFGRTVAIIKPTSSGGDIAFRAGDNCTFSFERDPTGLWKAVNVDLFSGDNLDMMNVTRVASALDGTVHNIRYIFECPDVDPPAPIYFYPERSGSRMGDRAPEERHVSRKRHLLECWPVNYFNDIANISRCRDNPWNVVVGQHGACSTFAVVVFSRADLLGAVAIAAYGPSYSGKLYALGIPIRAQVLVRRSLSGGVAVLWRARLLRFGTQLPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7M2</accession>
    <name>A0A2S5B7M2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7M2"/>
    <dbReference type="STRING" id="741276.A0A2S5B7M2"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="62" mass="6508" checksum="B27CB3E6C972562A" modified="2018-07-18" version="1">MGMSASFLGRLAPNLAMWGFAGAGALFVVGSAIPLFQNDILLKIPGVAAYYTDNTPDSDKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7M4</accession>
    <name>A0A2S5B7M4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7M4"/>
    <dbReference type="STRING" id="741276.A0A2S5B7M4"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="562"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="835" mass="92686" checksum="8824C1A25C3890D7" modified="2018-07-18" version="1">MATRSLPEARVAAILSDRFDDSDDTGEQPRQWERTAIRRWLKQHLKERRDEYTQQEEIRVWCGTYNVNDKVPKSADDIAGWMSDARGAELLVFAFQEFDLSTEAMFRYTTAREDAWRQSIEAVLAGNAGPQYSKLHSKQLVGALLLIYAREDIRDRFSDVSSASLATGIMGVMANKGATAIRLQYDDTPLTFVNSHLAAFVPNSAQRNAQYRDSTTQLVFPFTESSPRRDEWTTSLKPDAAHAVEGWNVWESDALVWMGDLNYRLDLPRDEIEPLIEHAEFGTLQAFDQLAAQQRDGLAFEGFSEGPIDFPPTFKYDAGTSTYDSSDKQRAPAYTDRVLYLASEDAGVSVDRYMSHPDVMLSDHKPVSATLKITTHRIDKGQRKQLALSALEQINMDTTAEPEPADVQLTPSSDVAFHSIEYGRSSEMQLELVNHEHKACPWSFVAKPDSARSAPSWLTVSPSSGVLLANEHQTLTFTARIPPHLSERLSFPEDATEQGEVCLRDLLILSVCGRDLFLSVSAKSRQPTILGSRLAYLAALNKPIRETTAEERSVLVATVTATAAGNSGERQATETVPPVLRRLVSFLAEHGLETPDLFSSDCAEEHMRSIIECLDSGAPFPPRFSGDAGDIADEPVSNEKEVPASEKQHLVDAVDLLNQLETDLGAVSLEPDNDAISDRSSIDSSAVSKAAALRPPRVDPVVLHAAGEALLRILRELPEPLVEGRLYDTAIRCESREQANDVLHGLDEMHGNTLLYLVAFLRVLLRQGGQDRPYRQLRLAIAFSQVLLRCPQDPETGARSIPDGVDPGSLPRRQKQFVAWLLEEEQGPTRPNAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Z7</accession>
    <name>A0A2S5B7Z7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Z7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7Z7"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="52"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="563" mass="60206" checksum="0CCB999FEBC24253" modified="2018-07-18" version="1">MGKGARNAHAKGGKSCGSAKGRDRTRSDRPKLIEDPELEEKVLTGQLREAGLYAANILGDGNCLFRALADQLYGSPSMHLAIRHEICEYLAGNADRYRLFVDEDSVKGGFDGHVREMRQPGTYGTNIELSAFVARYRRPVKVYQPNLVYVMPVEEAAPGTSTPPSSSSTPVPPSDIPSESAKLTPREKRVLARAEKTKAKDGGAGPKSKKGKEREWQPPVPPSAEDEGAEDSPLCIVYHSWEHYSSLRNIDGPHTGPPRLKVKRVASSRANTPSAVSPDAEIDTAGAERDADPAVDGDLDMAEAEKPSALSPSETEPPPKQHVRRVRRPEQTDHPLPAIRSALARSVANSDRSTSPPPQPIIPVIPPSPSSDVPSSPPSASPVSSDRPPKHLLDRSRPRSNSVASSSSALAPHPSSDTLAVGDPSSDAELDENDNDNVQPRTRSRVNSPASWSSSGSSTGVASSIESGASSDAASPAATPSHASPPPRTAPQRKAVPATRVRRGPTAREKKELARQRRMDRRRTKTLEARPPASSDRVLRSRGPVSPTAPDAGLGGKVRELYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B908</accession>
    <name>A0A2S5B908_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="5">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_3597</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B908"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02041">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="650"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY73263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1379" mass="149594" checksum="140549D4BD0104C1" modified="2018-07-18" version="1">MAAIYSAAYATSTAVQGATLVPSPLLTPAQLAKADSGLPALLAVEPHQLILLLPQLRTLAKSNVVIQVSTLAANRDHASVLAARGSGLSIVYSRSADEAKRNALVAARIAATGHGVVHYGEFDSNKVDLGFSSEADVAYVKGEDKAANGNGEQAHANGNGAAATNGDATAPSQIEVAFRTAFAQQHASTSTYTGAESPKTLLIALGDARPVEQSLPAEIALVSLSLYRPLSPAQLRAVVPSSVETVVVLEQVYKKSSKWAPLYLDVVSAFAEQDDEESAPKVLSATLGEVKDASAAIKSIQDAIAAGTNPFSVGQVPSAGAAAPSSSKAPRQPKHESTYTKLLDEVFGSRLWLANAPESLLPSQNIPATSPEYALGHVLGANRQREELRQRVREALASSDINERTAKSLSAWLDDDRNARKAKALGDAALPSSLSSAEFAPKSNWIIGSEAWSHDLGASGLHHALSTGADVNLLMIDTTPYHLPADQQPVQRRKDAGLYAMTYGNAYVASVAVYGDFAQTLRALAEADAYKGPSIVLAYLPGGEEDSTTALDLLKQTKKAIEVGSWPLYRWDPSADAQGREVFQLDSEKIKADLRTFLDRQNHLTELSARLPTFGEALESGSGSKLVAAQKRKARQAFDALSGALEGPPLLVLFASDGGNCEKLAKKFATRARTRGVAARTLAFDDMPIEDLPLETNVAFFTSVAGQGEFPQNGREFWKAVQAGKLADMSKVNTAIFGMGDSHYWPRKEDAHYYNKACKDLHKALTGLNAKEMVPLGLGDDQDPDGAQTAYKVWEPQMWKALGVDDFESTEPELEPITNEHIKIASNYLRGTIVEGLQDTSTGALAESDGQLTKFHGIYQQDDRDIRDERKAAGLEPAYSFMVRLRLPAGVCKPDQWLAVDEIADARGNQTFKLTTRQTFQFHGIVKSNLKPAIQEINKCMLDTIAACGDVNRTVMCSANPSLGPLHTQVFHFSRELSDGLKPQTAAYAEIWLDQKQVVGEAVKDVEPLYGEYYLPRKFKIAIAVPPYNDVDVFCHDLGYIAILDDNKELLGFNVTIGGGMGVTHSMKTTYPRLANVVGFCTPDQGLEVAKAVLTTQRDNGNRANRKNARVKYTVDRMGIENFTAEVEKRLGYKLQPARPYEFTSNVDHFGWATGSDGRRHFTAFIENGRVQDEPGKPFKTAMREIAKVHKGVFRLTANQHVIIADIPPEEEKTIQSLLNKYGLDKTDFSALRLSSAACVALPTCGLAMAESERYLPLLIEKVEALMEESGLRNDSITMRMTGCPNGCARPWAAEIAFVGKAPGTYLMLLGGGYWGQRLNKIYRESVDETEILDILRPMIKSYALERMDGEHFGDFVIRKGIISATTEGKAFYDGMCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B916</accession>
    <name>A0A2S5B916_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B916"/>
    <dbReference type="STRING" id="741276.A0A2S5B916"/>
    <dbReference type="OrthoDB" id="2520872at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="465" mass="51350" checksum="5D5C6F536C566B14" modified="2018-07-18" version="1">MQHRYATLPQTPDYVLSQDPLGQDTPPAAATGGDSPDSDSDGSDEKESASTAAAVAARTDLARRELRSLLARQQRRHIVQVLLLAGVGIIALSLAFAPSARARPDALRPATSPGDALQLPSMLVGPRPRFAPDGQSMYKGCSYDGLLRAVQGATVRPDGLSTHPNYTNVDYTTLDPFEWSFDLPGLGTADAGGGQTVEITEKCPPMPVWTQAQACELLSAYGGLYSTGDSYTRHFYTALMMILRNRNDGAVRNYRTTDDCRHEHAFDDGKLCRERIDVDTNWEEHVCGNAAQVGYVEMFWPDKHTYEIYRDWHSRQPKRNQMYSPVFITGIGLHFSFNMSIPHIAPWIDTDFDFMNRQHPLPAKLFLGPHKPGVNQLEKWIPTQGPPRLAAYKKAMVEKLAQYSASPLAIEGSWRYLDTWRLSEGAVNLEKAYTILTLLDVLWGEIVAAGGLAELRATAGSAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9F0</accession>
    <name>A0A2S5B9F0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9F0"/>
    <dbReference type="STRING" id="741276.A0A2S5B9F0"/>
    <dbReference type="OrthoDB" id="2507795at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="844" mass="87325" checksum="F52FE94CE060C971" modified="2018-07-18" version="1">MEGAQIVAQSDAEMTIDYDQPLHAVASAAEAGGDAEMGLDVTAPHDGVMTAATATDGLDAVTASLPDYTGEQEAEMRDDGSVPEVDASIVDDSALASIEVMLEDNNAEATMPAEVETTTTEPLADISFTAADEAVMTTTAAAPLDTATMAPLASFDLTADATLAPEAAFTTASEVSLPDETLAVDGPVAAADEITTQDAPVDPAPPLVPTVGDGGAAARDLELPETVTAPEALDRAAEFQEATSADSAPVATEEDPLAGGVPPLFEIASEKLAEQVDEAQAHGRDAEEASSKARPAVDKDPLLQVEIPAEDLTPEASTSAARLAPGVLVTCGGTTYCLFRQLQVANESTFTEDDDEEEGAIKPDADDRSASEEDAPMILDELAQHDLYYQPVERLLETLRSKLPELDGEADELVLDFEDLGITLGEDNVYTRQVSLFDFDRLHLGCQIPGRLHVHVYAQPRFASGFNALAQHIASTYSSDGPGSGAEVEDDETAEEEEEGVADDYDGPDSELPTVAAAEGEGDAPVNVFAAAGGDDDHDGDEEFDLDSALAQLDQDNIIAVVEGAQEDLMTSLPQHEAEEVGEEAEGEEVEGALETNDDAQQEEEDGEYAGPEGTAPEEEQLAGEAPVEEDSWQIVEAEEATGEPVGGALASASDANGHDATPATDGLVSTAELPAGGQPDDVEGQPPVELAAGSEEADKANGTSERKEGTDASAESEADGKPNPLGVQVEHAQTGAAVASDVGNDGTAPEALEASTDIPDATADSADVVIDYDEALDPTSVAEEPETAEITAATSTGACDAPPSPKRSRSFDQVEEVNGADEDSANDAKRPRLAEATEAEVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9R3</accession>
    <name>A0A2S5B9R3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9R3"/>
    <dbReference type="STRING" id="741276.A0A2S5B9R3"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19518">
        <property type="entry name" value="RecA-like_NVL_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="163"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="553"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1250" mass="136497" checksum="E5B6C49FE8EA5B05" modified="2018-07-18" version="1">MSASQPLLHLNRQLSGMAMGSSRQRQTLSLNQPSPLGQPATPEMTASDQDPAPTASTSALPATTATTAPTSGDPAPAAAAAAPKRRLRPSTSSRDPSTPKRLRGAAAGTTGRDASATGAASFQPPSTRLADLGGVDSCIEQMLELVALPLMHPEVYLHTGVRPPRGVLLVGPPGCGKTMLAGAIAGELQLPFISISAPSVVSGMSGESEKTLRETFEEAARQAPCILFIDEIDAITPKRETAQREMERRIVAQLLTCMDDLAWDKTENKPVVVIAATNRPDSLDPALRRAGRFDAEITMGVPDQAGRERILRVLMAKLRLSGDFDYARLAKETPGYVGADLSALTGAAGVLAVKRIFETLGVNGDEGRRVGTGIPLDLATAEGALAALVRPDSGSSAEDADMTMADAVPAPAVATPPLDPGSVPSSIPGSGATTPRDEGLPGSDAALLAAAVPALPFSSLPPSLANLPISAFLRAHPAALTEDQLSTIALTNADFVRALSIVQPSSQREGFTTVPDVTWDDLGALHHIREEMRMSIVRPIRRPDVFKLLGLNAPCGVLLWGPPGCGKTLLAKAVANESRANFISVKGPELLNKYVGESERAVRQVFARARASSPCIIFFDELDAMVPRRDDSLSESSARLVNTLLTELDGLESRKQVFVIGATNRPDILDPAMCRPGRLDKLLYVDLPSPAERIEVLRAVTRKTPMADDVNLEKIATATKADGLSGADLSALAREAAVSALREMFTSIDLDGPALDVHSAIAVAGQPVEPPRVSMRHFETALERANPSVSRQQRRRFEALRRKFAGSPLGHKGEAVEQDGPDGEQQPAETAVPFNNVWRPYEEDCSASQLFQGMIRGDTTLRSPASSDGNIRYPWLMNATVLLVGDSMERLHLNDFCDLVGGEAINIHPNHLASPPPYHKSIKPVFGADGLETAESKMARRQRKQLEDAWERREHTWNYMRPWVCDVKEYNFTMLFTFAWGMEDMESVFQSEDFYHAPSTWLERFHHIALPLLHNVAHYLKRPHVAHPTLIEISSGYWDLRGMTEQDFIAAGYSRPYPKDSDLAFGPIGMSRERKWVKNVRKVIKDVAQTFPGSNGVRDGPPILWRTMHHVKRNNYTPYSRVAALDALARKTMHELRLSSLATYPSSLSALFNSAPYRQEARKYLAREKRRHSGSGRDDEDDWLESDGIDYGFDERLRVDEIGRLLEGQEHHMRDDLHPQVLPGSYVWADILLYELKRSYYRVGRTNQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9T3</accession>
    <name>A0A2S5B9T3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9T3"/>
    <dbReference type="STRING" id="741276.A0A2S5B9T3"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="275" mass="29545" checksum="E9249E2741C6BF27" modified="2018-07-18" version="1">MDDLFGSDSKQAQQDPAGDFLARERAALGADAQSFAAPSDSDAFDKDYEKSAAAFPDLEGSGGADDVVLGDFAGGGNHAATSAVTTGQQVSVTGNDEFAAFEEEYPEIDLPSEQPHENGLNGSSAPEPAPAAFSQPAAASTQSATAPQDSGDSEIIRNWREQQKADIAKREEESARKKEDTIAKARNAIDNYYKDYNSKKEKAIAQNKDDEEAFKTQLSDSLAKGTTWERICTLVDLQDSRSKTTTKSKQDLTRFKELLLSLRREGETAPGAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9U9</accession>
    <name>A0A2S5B9U9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9U9"/>
    <dbReference type="STRING" id="741276.A0A2S5B9U9"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="18"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="352" mass="38470" checksum="31A7E122F026F47A" modified="2018-07-18" version="1">MSDLKFRGYAIKDEKKWTEFEVIDFEPMAWREDLIDIEIEYCGVCSSDVHTITGGWGEPFKPLVSGHEAAGIARKVGSNVKSIKVGDRVVVGAQVDACGSCRACESNNENYCAEQIDTYNAKSKDGKVTQGGYSTAIRAPEQFTFKVPDELPLEDAAPMACGGLTVYSPMRRAGVKQGSKVGVAGLGGLGHFAVQFAVAMGAEVTVFTHQKDKIEDAKKMGATHAVLTSEKDWQKPFAQKLDYIVCTIDNADAVPFSELISCLWVNGTLHFCSMPDSSLPQFKTQDLAANGASIAVNHIGSKVEAEEMYRLAAEKGVRAWKQIVPMKDVSKAVQGVHDNKVRYRYVLKQDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAS8</accession>
    <name>A0A2S5BAS8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAS8"/>
    <dbReference type="STRING" id="741276.A0A2S5BAS8"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="136"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="469"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="562" mass="59509" checksum="30059AB5D8E5439F" modified="2018-07-18" version="1">MPPRKARGTTTTPKSSPTKPSAKARGKRKAPESGVASPSPARRRARLAAPSGGHSDDSDGDDAYRDDEGPTEQFVSASGGDAYMLYSTQTSKTTDALLSTVIDPAFTLASYATALRNYDAVSSRHVEQDRQARFDKATTRFPKWTLDLEQGFNVLVSGVGSKRRILNEYAERVRSRGDVVVVNGYDTAATVVDLVAALEDIVRSRGGGHAATATAQEQLRTSPRKQRSPKKPTATRANGAATAAGGAYASARPVSALESRVRRLCAALSSTTRPVYLVVHSLDGPALRLPKNISLLALLAAQPLVHLVASVDHVRSALLFPTALSTARPPYASTSSTVADEAALADLRLSFRAFTWIHYDCPTLVPYDTEVASLGTLSTLLPPSIFPALSDSLDPTAASLAQSATHVLASVTDRARRLFNLLGQEQVRVAESLPREVERGLRLLAASSSTTAAGQGTAAGGVGGQQDKAPVVAVSLASLKEKATDALIATHADQVDGFLSEFKDHGVVRASVIAPDKIRGVNEDDDDDEEEEEAGAAGGEWVWIPLAREALEEVLTELGIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB54</accession>
    <name>A0A2S5BB54_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY73993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB54"/>
    <dbReference type="STRING" id="741276.A0A2S5BB54"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF89">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="898" mass="97554" checksum="1E3D31C670F3F4F1" modified="2018-07-18" version="1">MSDSWQPPSGGGDSQPLYYLNTDPVDPQWSARPASETTPSPLEAPPSQHSTPAYRFDGANAAETACNNDRGYAVFADGLAQSQQYSTHGAASAGYQDPHYTQPPHTTASRQYEYVHAAYQPQQVPLAFSDAHLPLPSATDGVQFTSRFELDMLDTPTESDGEAYRGGPARNTARSPSSKPRAAPTRKRHIASCTPCRQKKTRCSRSRPCTACLDRGDPAGCIWEGDAMPLYIASQEDEVVQLQAQVKQLEGLIASLPRQTASSGSGVNSLSSAPSTSQRRMSSQQALDYVLGPDTAQHPKHDLISQDLCGALLVLALSGTVAPPHAGRESFLPSGQSGVDFLQEAKTRIAGSSSAASRLEDTPSPDAYGAVVGIPGVLVTAAAPVEATPTIRTILPLLPTEHELRTSFDFYRQHSYYICPTVNSDTVRTRWRILLYLLGSEQQDQQLGSEEAQFVAMALAVGAMGLASMTDEQARSHGFATERISLATRWNRAASMCLQLGKFVEKPSLDGVRAATVISAFHVFLSKGDTLPAGLALLSLAANAAIELGLTRDPKHLGAQECSFGQGEERRRIFWSLFTLSTVVSTVTGRIWPQFDLRFIDVALPEDFWDELVYLLIERCPNGLLTIASFSFRELEMAERAARARLRARQAGDFQETAMSAAILHYKLAILVKTATEQCFTAAGCQYETILSLDERLIALESRLPDVYVLSSDSRPSLATGELHGTTHQRAIILNLCIAAEMLRLHRPFLGACLSAERDFPFHGSIVLTPQYLAAALAAFDDRYQYSRAQCISYAMRILRILSRPYRAWIEFSSCRPTDSFSIADIMAAISLAVDLLADDPQDDAEKVVLVEVALQRMDSLATASPGGPAKTGTNGVLGAITLRALLEKKSMARQLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBD5</accession>
    <name>A0A2S5BBD5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBD5"/>
    <dbReference type="STRING" id="741276.A0A2S5BBD5"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="9"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="267" mass="29374" checksum="2427C76C2F764C5E" modified="2018-07-18" version="1">MSDAFLSYHETIDAVRDFLEVAFHTILYIRQVYPLGKCHLFEQVRKYGVTTWQCRNPLVSEYIGKIVSCIREELHKGTVRRVFLAIREDNPEATPLERFVFDIESLLLQSDLAQDGSDFVPRANGILPGDVEALLRACMIKLNVSTSYLSPIPPETALTFAVLLEVKDGSAPPASKAAKAGSVPAEWIPADQRDAMEDNGTGTGRGHTAARAQSTISPVTGVRLGMFNLDLQVEELAEKFGTDLPDDAATDSSGHFPRRDRKGKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBF1</accession>
    <name>A0A2S5BBF1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA repair protein RAD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_2924</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBF1"/>
    <dbReference type="STRING" id="741276.A0A2S5BBF1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="390"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="853"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1043"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="434"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="561"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="910"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="979"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY74112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1214" mass="133752" checksum="E011068F73EE59D6" modified="2018-07-18" version="1">MQSEGLFRASSDSEHEEPPAKKARFFADSDSDEDDALVFESGAAATATTGPTAAPPPVAGPSKIKSRSPPRTAALPAGNARSKVDPDWSSRYFGDVFVEAFALASSSSFVKLKAGETITLHRLRPKITETDSKKSAAVKKKLEHDVVRFKNSKGIEVGRVARDDGAWLAKLLDHDMLEVTGYCVACPEKFRSGDDMQLSLSISIKKNAFTDPNIHAAEPAAKPSTVGKKSFLDDLQETEREKLMRERKKALNILFDKADLQPYQEDSALPTGSQSKRVMLDRMEKRTGVGDEDEEDEMSEIQLNLVYSKAIKNDANLPELDPPDSFALTLRPYQKQALRWMSAMETGEEQARKSLSMHPLWEKYLFPGASSAADCFYYNPYSGEVSLDFPKASTRCRGGILADEMGLGKTIMVASLLHTNTPWTAAASAATDASSAESDLDVEEVSKPTRTQPRIAGGGIFRSSAGKAGSRKSDKPPLKPGTPRATLVVAPMTLIGQWCEELARSSKGNRLRVLMYYGNKRESASDLQQEIDEGVDVVVTSYGTLCSDFKQSGLDLPAATEKSKNATADEKKLAAARSKGKGKAEEGKKVKRPKRKGLFAIDWFRIVLDEAHLIKSRATLNAKASYALKGERRWALTGTPIVNRLEDLYSLLHYIQLEPWGNFSFFKTFVTVPFQNKDPRAIEVIQVILESILLRREKKMKDKDGKPIVALPEKHIDIVHLSFTQDERDIYDALFRNAKSKFLGYAKEGTVLQNVTAIFSILMRLRQAVLHPSLVLKRLKENLRLRQGQASSSRGDDDADQASQIEDVAIQRLIESYIAGSGDEDSEQAASQVIDDMIETDTAHGVRLEVGECMLCMEPVEVPVWMPVCEHVGCKSCVLQHLTDCQDAGEPARCPVCSRGPLSERDIADLQRADGKKPKPNAKKSGYSVDKVASSPGPSSSKEVLTLLSSDDEDAPLSPKKDVKGKGKAKVTEITLDSSSDEDGGGDDSEDYMPSSPPHTTNLNDDNDDDETGKLDSSDDEDGQDSPNRQMLLSKSDFRASTKLDALVKSLQKAKEKDSKLKAVVFSQFTGFLDLIERSMNRENLNYLRLDGAMTQGVRQKVVRKFTTSDKSVILLASLKAGGVGLNLIAGDHVYLMDTWWNSAVENQAIDRIHRFGQTREVYVTRFLIKHSIDDKMIALQERKTKVIQGALGGNKDKDKKQLAEDLALIFADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBG9</accession>
    <name>A0A2S5BBG9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBG9"/>
    <dbReference type="OrthoDB" id="3261505at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015645424" evidence="7">
        <location>
            <begin position="25"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="480" mass="47682" checksum="E5B7FF31E284B338" modified="2018-07-18" version="1">MKVSSASGAPLAVLALAALVVADGQHAKPDLVARTPDLASHHSHARMRLMHKRQLGLGNLIDGLTGGGGGGTADTASSAAAAAGAASATLSSAVAATTAATSSAAAPTSLQQTSAAAATSSPAAPTSAAATPDTTPQTQATSSAVAASSAAPTSATRAVAATSSAVASSSAPVSASSAISQPRVASSSTPADQSTLTVETTLSGASSVASSASSVSRASSSSASSASASDAALNSNGGGSSSSGGLPKPALIAIIVVGSVVVGALAIWTVIRKTALSPSKRFEKRLRSELDYSPNPTDPDLNNHNFNYDPDDAHLVPGTLAHARNISGMSEERPYGMVGQGVAPGYAPSLARSDSGKNSLTGSPPLMTEGMHAVPVMPYGGGPQYVPQSYYGAPTSPPIGPGYPQEQPYAFGELNRAGSSASLRPTSPAMQIPYQPPAGQVMYEQPGLHRMPSTNNLGVPGAAIDYGLPYRPDSRSQTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBU6</accession>
    <name>A0A2S5BBU6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2678</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBU6"/>
    <dbReference type="STRING" id="741276.A0A2S5BBU6"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000007">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="222"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="421" mass="47464" checksum="423035EF4693D926" modified="2018-07-18" version="1">MASTSTQSRLDQALALQDPAQQQRALSDILQTPAGPRDDQLLKDQEQAIVKLAQLYRDQKDAPALADILKQSRTLVVNLAKAKTAKLIRTLLDLFSEIPGSTELQIEATKESADWAKNDKRIFLKQNLETRLVALYIDNQNYKEALNLINSLLRELKKLDDKMILTEVHLLESRVHHNLVNLPKAKAALTSARTAANSIYCPPTLQAQLDMQSGVLHAEDKDYKTAYSYFYEAFEGYSSQDDARAVPALKYMLLCKIMLNLAEDVALIIGGKAAQRYAGPEVEAMKAVAKAHEDRSLQQFELELRERKKELSDDPIIRNHLAALYDTLLEQNLMRIIEPYSRVEIAHVAELVKQPVRDVEIKLSQMILDKVFNGILDQGAGCLIVFDEPEVDKTYDDTLETIGHVSQVVEQLFQRTRTAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCG7</accession>
    <name>A0A2S5BCG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCG7"/>
    <dbReference type="STRING" id="741276.A0A2S5BCG7"/>
    <dbReference type="OrthoDB" id="2529143at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="738" mass="76152" checksum="76ED0F6B3629E972" modified="2018-07-18" version="1">MAQGGASGDRPSIGEANVALASLLSALKQSSASAAVAAGGPASSPAGQQAASSPAAAAAGLTPQTGGPVVAQHSSPAFPPQPHQRNLQSAPPAPSSSNAPTPSFAADTPEQQHGHGHGHGHGHPHGTNWSGQTAAELSELGTYELLLQLGAHLGVMKPPPSTTTTQAGTTGTPSAGSTLQTHAQTDGSATRTTSLAATAPTPVDSGLRDSTYRPQPTRSGRMPQQSRPHNGPGDSTDPSMSTLLFNDFFDFPSSEDEDDDPDFDPNAPADDFWGDLLARERADGDLTENEDAGWGTGSGGNGGGGGSDAGAAAHASGITSDEFAREIALLTSALNDPLPDLSGRSALPPQPTRTSPRRARPAATAFIPSPAEETSEPVAAPARKKRRTTRRTLSPVLEDTPAGSSGPQRRTGQARDVLPPPGQPLASLSPRARRTQVPLPAPVVPSRYDGYGASDSFGRQPGPPSSSVASPSASPPPEADAAPRTTRKYSKRERVYTPEEAAERRRVQQAERMAVRRKEEKEKKAQEEARIKGIEQENATLRERCRWLEEKCRDLEAKLEAAYDDPRPSRSAVATSRLRARPRRRLEEEPAMSKAKPAATTGSSAKMADSVADPNTGGGGGDDDESDGGEYQVESTEESSSSSSGDDDGDAQDRAIDEDDLTPLAFPTDSPATQAGTPATHYSSSALPTGAGAAVPAGPVSLDLSSMGGPALSQLLTLVRAAANAQGISMPTADASHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCI4</accession>
    <name>A0A2S5BCI4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000024">
        <property type="protein sequence ID" value="POY74485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCI4"/>
    <dbReference type="STRING" id="741276.A0A2S5BCI4"/>
    <dbReference type="OrthoDB" id="2537937at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
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        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="809"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="964" mass="100623" checksum="67500D72E03A65BA" modified="2018-07-18" version="1">MAPTSPPPSSSTTRPPARNKSSSNLSTQTLKSLSSTTSHGKPRRNKSTASLTGQHHGYGAGHHHVSFQHHRRPSHGTHGLKRVGSASGSSRKPTFGLGMTTMGDPESPELVGAQDDDSGASPSAAQTRRPSMSKRRTSSSSTMTVVSRPSHERRTSSGRRSRSNSGAHAGLAQQVEQQPSTSEVDTITGETQPPASAVNGSVTSSSGDWESATDSPVKIGQKLPDTAEEFQPEEQSALARALDAQPEQDEADQQPQQQPQAGGRAGGRKAKFQLGASDPFEDDDEEDDAPDAPEQKFAHQAGTQPAVPPDAQEGQVEATMGEEIPDVVPQAQEGSIPDAAMPPAATAALPALPATIHAAAPPTPEQGEAKLSPEDEQEAAAVAAPPPTSAAQHLSPPEIPQDEDSSTKKKSHSSLLAAAQPELAFPNKPPSNPPSQNSTRPSSPIPNPATPPDGPTDPLSPNPTSVQREKEQEEQKAGAKRSSPLKREAKITDDRKSSEADAKPGLPRQKPARKASDASIMSTMSRRSYFDRPAPQFRRTASGVAPPSIDRDVTARGDFSGPASDESRRGGDRRSGHGRGDSINSMRSLRQNSDGAALASPQSRHGNSLAPAEPRRSRSSESSSSGALAALGNIAASAGRSATSPAPEPGLSAAKRSASGYFNALRGFTTLPSTSSTPPLSPAATQTQRYPVPGPSSSSYTRSSAATRPRPSPSPRQPPLVVKFVEPPQPKLPPPTPSERSTQDQRASSPAALRGNLSAQHRNSSSASLGPMSRTQQKALLARDAPQYAGGEGGGALVPPSIPGGLTPAQQQFLALQQQRAAAAAAASAGPSSAAGSSPASPAPGAQGVNQGMQKWAFGLVREAERIERQYRAVEKWRDPLGESLERVLIVRQRARRRREDDREKVRQAIAAAAAARQQQAAATSTGGKSHAGTPISRRSSAGGTSETDSRPPSMRGKQRSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCS9</accession>
    <name>A0A2S5BCS9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCS9"/>
    <dbReference type="STRING" id="741276.A0A2S5BCS9"/>
    <dbReference type="OrthoDB" id="2526774at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="388" mass="42640" checksum="865B16A78CB58978" modified="2018-07-18" version="1">MPEPAASTSGGVSPPEAAWSVTGDKQRSSFVLKLHELLCADEHPEFLHWVNNDTFAITSLDANARIALSPHWDFNSLSSFIRQLSYYSFKRLTDRRRSVERRPSAPTYIVFTHPSGNFVRDDETKALLIPRKLRARKAAAKKDRPAADAKEARRPLCPPASTSHQEFAHLSGSLSQSLAEYNGLQDSLTRFQLPVRPDASLAFPPSVSPRTHLPALPPVSFPYGSEAGSFVLRSPPTRAERSQQARHFEPSHPTPVVPGGGGAYLDVHSGHLVSETSYSSQYYTATRPASEASPARTEQVPNPRANGMVVALRTPPPSGDDSSPTLPYSDLPPLRALPTKPFDPAPGEIGRRSTPFTDYDRQYIQLSLVQPGVSTPASPPHQQFWWQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCT0</accession>
    <name>A0A2S5BCT0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2346</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCT0"/>
    <dbReference type="STRING" id="741276.A0A2S5BCT0"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="72" mass="7806" checksum="F0C9FC1DC2B7EFEA" modified="2018-07-18" version="1">MSEATYRYNVVMTCSGCSGAIDRVLKKTEGVTSHDISLDKQEVVVKATIPYEDVLAKIKKTGKEVKSGEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCT6</accession>
    <name>A0A2S5BCT6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCT6"/>
    <dbReference type="STRING" id="741276.A0A2S5BCT6"/>
    <dbReference type="OrthoDB" id="2537459at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="541" mass="56036" checksum="A2F145BF0D3EE815" modified="2018-07-18" version="1">MDRSSDSPGSSSPNQGGGTTSPQSTSTAPASSATSSRTTEAAPTTTAAPTSSSTTTFQAAPSSSSPPPSSSSSSTSSRASEDTAACIVFLVRTFLQPNVYFRSTLLLSFHFSIRRILQLGGNDTVDVCVVDKLVCSSFTSYLLVSSVLFGGSGRELDEQSIDAAVQTHTETSQFTFTTSGRVVVVTSVYTITAAGAASSGVPQLNNAHDSGNAFFANTGAVAGTFVGVGIVAAAVAAFLFFFFIRRKRRRQLDEDIRVATGGAGDGGAGFSRFNDDDDDESFVGGANARSSVGHLSSTTRMSSYGNVPLAGAAAAFGNRRSSNLDVASSTNTTPGIWEPSTAEFDPLPTASPVHSISSLPPMQQAYSGYGPSFAAFAAGGPRSHEGVLHDDWQEYAANNGLRVPAAAATAASVPGYEPASRAGSGEGSSGDSQEGMMGSTLYTGEGAPTPRRRDSGMSFYPEDAAERRSMGNWRHSFYGSSEGHGTTGPYGGLAPMDRISPPSPRIDDRLNPNAFPVAHNHSATSLGDENDYSRPILRVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD76</accession>
    <name>A0A2S5BD76_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2537107at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="928"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="969"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1381" mass="147428" checksum="7FB2575B3BC23D1B" modified="2018-07-18" version="1">MLSSGNIRPLPSYDFGRADGPVVTAQAPSLFSVSTRSRPLSTTSGVSLASTTSTSSYTFALDRRRRSAALLELAADDATRLSLQRAEGILRASEDARARDQRRSASLRSRGSFVHDLTRSTGQVTFEIPSSVSSLEELRGGDEDGNRDNVEPSENLRRFSPKRFLLGRPRPPRHAATTKFNTISSPMALAPSPPRNVVSDRPRGRGIDTQNVPRSAAPARSEPARRFGTLPSHFSRLHPPPDDSLSKFSGSSSGSLVGIKGPSREEVTVKLDEKPRRAPKRGFKALRQKLAGTRRGSIEALSKPLRKRGSFASLFGLAGAVPDEASSTDDRQTSSKPATTSASSQQTHSNSGASSHRPSTSISSFATSSASATGSVAASRSSSRLGFFRTLGRRSSLTSGRSSRQSRVSGQIETSSISAPLPLASPQRSYAGPDPTTRATDQAHAKVAQLPVELGPSPLRKKGWLSTWGRSAGGQNVATKRALFEPEGATATGSDGLDGLHRRRPQERPLPRPSAAVEPAPAAPLVKSRAAAFDALAIQTSVPRVRPKIRLGGQLRSKAPSPRHSLQLLVQGVRPLDTVGRTDPTRLNRRASGRAGSGFPSPTSSSSGRSLAPTLDSAGCDSPTSAHCGNRLASQTAGSPLKDSRGLPVRLQQSSGDPSPRKLALGPEHGDDQIGARHPFGGPIRRVRGATTDLAELLGGLDETCDVNTSALDLHQPNLHSDSVAHVGAANGAASGLHDLMVEVDERLSIQLDDMVARGFGDEDGLSTSSESSSSEDSFEEIREPFAPQVPTSDYLAAPFEYTAYRSTGEVTTSGYDMTKSSFEGHYSTAAAALRSMLSGRDETGPPPPVSATLRAFPAPASATLRPDQGWLASPVSPGLSRHEADRPTAGEKMFDRAPEVPLSTLVHSTPSDGGQSFIGHHQPRLSLESLTTSPSPSPAVARRARQSLARYSQDGSSVRPEHAARPESMSSLQSSLHSITGELTSQSLAASTRSTNLSVTSSRSSPCPAPRRRRIPMLTGKPIPLRLSFKFPLPAIRDEDWQHEQVSAPVQPGRPLTSELSLHDALLPPPVLAQESISPQRVPSGPFEAAGPFASASSDRLIELEPAMHSYEWTACTNVDSTRHYCALVYEVETELKRSLTLWPDTDYSREMLACFVIPRTYSAILDFLFASQNRFPSPVSLARLPSFIAPAFENPLQDVDMYSDGSPPASPHSVISPSRYCEAALPGVGRPNMETSAAPLQSPVVKIRPPAARRVLAEKAVNKVLAGPLAQDVGAGTAETALSPFSALPPRLTVLRSRPVCDTAFLGANVTYRRQDQLDAAMRRLEGVGVPEEQRSGGETDDTGVYEAHGEATQELSFTQSPRPTSNRPRQSHRTLLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDA5</accession>
    <name>A0A2S5BDA5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDA5"/>
    <dbReference type="OrthoDB" id="2524570at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="376" mass="41060" checksum="D1D22F3D5300E5E1" modified="2018-07-18" version="1">MPGTFGVVDQPTVSAPQLDTTYAMGPAQIGYLVQILLFGIFLSLFFECWSSGELARTGPLGRTALTTSLVLNSFYTALCFHEAYIASVWQNRTWAFLSNADAVFNALPLLAGLIAVTTEVALAYRAGKLLPYMWLRVAFGLWMSLLILAVLTGSILACVIGVQYFNGAERVAIQWGPTAAIWLWSSAIADVTISLACAYSLRTRILGFNRKTDSLLRMLIWIVLRTAAYTAIISIAGAVVESIYKDEDLKSFIGNAFWLPTPALYGIALFTFSVSSRRLIDSHLGVEAGPPEPGAPQPIRQPDCSVEQKPTTAAESYGPLSMVSRLSRALTSESSAPRTPLIVTVQRETQIHVDEEDARSVEETFCRPPAGKKRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDL3</accession>
    <name>A0A2S5BDL3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SART-1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDL3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDL3"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="762"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="95638" checksum="5B04AFB0251811A5" modified="2018-07-18" version="1">MADSSSQWKESLSLEETNKIRVSLGLKPIADPAAASSGPPAALEGEALAEDNYAKRRAEEQKAKEAKELKERIDKARNQKERIRKLGGRGLGDLDEDEAQVKQEEGAAGDDAKAWVRRQKKRAKELAAKRAKEQEEEDRLAEEEERDRANKYGERDLAGLKVAHGAEAFEEGEDTVLTLKDSRILDDEDDELHNVNLSENAKTKHALDLKKKGKNAGQYTGLDDDEFEGGPGSSRGVLSKYDEDFDSIKVDGFRLGSAPSAASAKGKGRATDGDDAMNGSSEREKVKLSMDYTKTFNTDYLQEGEAGFKKPKKKKRRAMRTTTLGDEPDDAAAGGDGMDVDGEPATPRRIERVSLDETNLIDDDDLQLSLARQRREAAKQKIKEIKARTAAAPPPRNNGDATVKKEDADENAETTLSRGANVDEDDVDDGDVLVLDDTSEFVRNISLAATAAAERAQKEAEKERRREEEAAIKRERGGSQSVLPRVKAEEQDVPLSEMDADAAPVNGGWGPAREDGEEDDQMYDFDAPAYGVEAAREERQISNEPKPHIKVEDDELATTAQEQLVSRGLASTLSLLRHQGLLQTRTPEELAREKELKQREAWLAQQRRRQEEREREKIESRKMGDKKDQQQREYENRMREQREAQSTLEAFANYKPAVNLTYHDKFGRDLTPKEAWKQLNYDFHGYGSGAKKTDKRLQKIENERKQMAMAAGDTPRSTAAAFAARAEKTGSATMILGVGNNNSAPMDDHTLGGVPRIEKNLKGKGKAVVAPHGRSGRSATPSGPNGAQPVFADIPMRPLPLPSGSPREASGTPEPSRKAGFAPVRSFSPATAAAEEERRNGGESGPKLSIAVKRKALGEGEDSPASKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDM1</accession>
    <name>A0A2S5BDM1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDM1"/>
    <dbReference type="STRING" id="741276.A0A2S5BDM1"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="34"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="267" mass="29676" checksum="C606150081E678C2" modified="2018-07-18" version="1">MSSTSAASGSGETFSFQAEITQLLDLIINTFYSNKEIFLRELISNSSDALDKIRYAALTDPTQLDSEKELFIRITPDKENKTLTLRDSGIGMTKADLVNNLGTIAKSGTKAFMEALSSGADISMIGQFGVGFYSAYLVADKVTVITKHNDDEQYIWESSAGGTFTIAQDTVNPSLGRGTVMILHMKEDQLDYLEEKRIKDIVKKHSEFISYPIQLVTTKEVEKEVEEEVEEEEEESTEDADKPKIEEVEDEDAKKDKKKKVSTAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDS2</accession>
    <name>A0A2S5BDS2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDS2"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="469" mass="50149" checksum="3461593026506AD4" modified="2018-07-18" version="1">MVAANAAKASKSFYRSTVFQIIVIGLISFVGPGLWNGAQSLGAGGALEPYLVNAGNSIVFSLMGLGCVFAPVLINTFGVKNVLLAGTLGWTVYTAALYQNNRYGTEWFVILGAVICGISAGLYWAAEGAIVLSYPEPHKRGRYLAIWLFFKNSGTILAGAINLGTNIHQSKGGKVNYKTLLAFIALQCLALPFALLLSKPEDVKRDDGTSVVLPEKNTVKQQLGALWKACSTRKVGVLLPIFFSSWCYWGYSSSHLTLYYSVRARALASFLAAITGVIATTGLGFFLDSQRLSIAARARIGAAVVMTLFSGVLVWAIVVQHSFTAKNPGKLDWTDTTGNFGKGFGLYIMLNMAGNCVQNYLYWLISVLAEDLGVSARYAGLLRGVESFGQCAAFGMASSHFNLTYTVVVVIVFWAVSLPSSFLTILKVGLAEGYGKPVPISSEDPSIADSDSASLDDKCVSDEVASDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE48</accession>
    <name>A0A2S5BE48_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE48"/>
    <dbReference type="STRING" id="741276.A0A2S5BE48"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="833"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="902" mass="99243" checksum="E959AA7E1B757ABF" modified="2018-07-18" version="1">MPPNVLRSDELHIERSATRAGSTEKRGKTVPHLTARTTAIMLVPDYLKVAALLNNQSTRARALESLASEGPDRSSETMRALLPYLSLPTLLSLRSSHENLGQVVTETLYDLIDAQRDWVVSPECPAELRDAYLVRVFGKEWDEIQDRMDEVASDKLGQVSETTILPGTGKEQEEGICATLSGFETDLREVTGGLLKNVDWSNVIIGGGAVLSILSGKTHDVAYANSDVDLFLFGLKPEEALVHSQSKELTAMRTYPQLLPKVAALIEEIQSALPRNKAGKKGQADLESLVRRLPSLSLDDDAAAWTAAHKDELLIVKGFNAITLVPPTSAPCRRKIQIILQHHASVFDALAWFDLDACAVGYTGKAVVALPRAVRSQSLSNDWRGGVNFFDPWLARKGDSSGNMLASRVIKYQPRGFALALAPAAAAFLEAQGIKLAEQLTSALVRTVINRDAPLYGLAALFRREQVVRDNAEKAATRTATMFDYGYDSEESGEFDEDDEDYDDYYEHDYGFGRHASRRARFASEGTKSKDNSALLEDYWNYNMIDVTNAVKSLMTQIEMVATMFGSETEEIDRGKQLSDLLIPYVSSFDGRGALGLKPEDLKASRVPSLSDTALSMDVLRSVQYIIRIPASVLPIFDRAEQKMRDLVERLRNGKDEVASKPAPAQDFPEAVSQSFHRVLASAPGATAPNSTDIKVDHAKPLKVFVPECFPGPARREDKLGANAFGLGGVEETAETHHLLTPLTNAAAGDETEGKWVYRVATIAGLWQIRGLDPEIDQALNIIWEAWTIFSHAAVTLPEEPSDKKSSRSGALPTKLQEQDATLDDLIPSSDGPGARRQPAQTQPQPNVLKVLSSMHRSLSTISEAAWRDEARQGSVETDIDRHWTGDRARWLEQWLTGEEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE55</accession>
    <name>A0A2S5BE55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="741276.A0A2S5BE55"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Pop1"/>
    </dbReference>
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        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="136"/>
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            <end position="777"/>
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            <begin position="1"/>
            <end position="46"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="44"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF22770"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="779" mass="85985" checksum="994295576FC6E211" modified="2018-07-18" version="1">MPPKRPGDGGLTGAAQKRQRMREQRTIPVEGGHARPGGSAGSGNVGLPPVLEVEKFAQARAFEITAMQRAMKTAKEAGTQRAFQSLPRHLRRRAASHNIRRLPERLRARARGEVPKDAAKPKRVTRSMLGRHRQRPGLKAEMFRKRQADKMWLETHVWHAKRMHMTEIWGHRLADRPTAKAFRASYRASQHGALVHDASYMQYFELEGGFDNLKVILDEICDPAATSPASKRYSTGAREICVDVYDPEASYPCGRLGPATFIWKPETPSEASPIASTSTSPSPPQRRTLLIRVHPAVARVAALAVEHVILDKRLGLDVALRRFDKEFLTFEINGRRSTEVVKAVLKPTNATNGQTKSAWRALDPQAGPAGLPSGMIIGLDVYDPRLSFPPQLEKSTSRADEPLLPAPAIADTSMFWNAKHRSSIRKPRYKKAELDARRSENLVPGTRLAPLAQDDRLPVLLSQRTLSAPLSHEEAIHGWTLTVPAGWGMAFWSSLVYSTPRVGGLRERSQQYQEARALRFPEDAVDTPGFDEYEVRREADEKGYWDRRPPAKRPSYDKFGTGSPFRVDMAGVLSTASRRAGPDVLRPFVLAPLIAERIHSTVNADTKADAKQGALAPLKPLARQRASELEEQLKQEWTSVAPSADAPVPDLLASAMVHVRVTPCTRGVPQDYGMIYELSPPVVSDVRKKVETSLAAKSVLATGEGDGPEDLCDRPKPDQVVGRITTGSFSLSDGRGSGVAVVSLVSFLRIASSQSGKRPLVLFRNRDVETFRAAFVDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE86</accession>
    <name>A0A2S5BE86_9BASI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2530492at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEH8</accession>
    <name>A0A2S5BEH8_9BASI</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="AMPK1_CBM"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
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        <location>
            <begin position="1111"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1146" mass="113639" checksum="3CF8292A56AB8077" modified="2018-07-18" version="1">MSTDQQSHTFTWRGHGNTVIATGTFDDWKCSLPPLNRQADGTFSGQISLPPGDKVLYKYVVDGEWLTNHAEPIEYDHSGNANNVLHVPAMAAVLAPLAATPETVVIPIATTSATESALPVPESIGTVGGHVAESPAATTTTGSTSTTATGSSKPLTEQATETAQQVQARAADLASQAQAKAQEVAPQVQAQASDLAAKAKENAFPIAATAGAAVLAGAGAAAAGLASLTNSAAKALETPHDQSAATVSTGAAGTHDEHTAVVAKEAAPDAPTVPMGAGDNAHTTTVPGTASSTLVPDHTAVVAKDPAPVAPTVPIGAGDNAHSTTVPGQTSTASTLHDRAADLASQAQTKVQEVTPQVQAQASDVASKAKENAFPVEAATAGAAVLAGAGATAAGLASAGHSAANALENASGLSTSTTENRAPINDVASGPIPRSVTEEPKSPEATPLTGSAATGVKSVPTLPSDAAIAQAAGGSRDSTTLAAPKYDEHTAVVAKDAEPVAPTVPIGAGDNAHTTTIPGQTSVSSATVPEHTAVVAKEAAPVGPETPIGAGDNAHTTTIPGAAESALPADEHTPVQGFIAPKENPEDQHLYHAGAAALGAAVAGAALLGEKLVGAVQPHAEHAKELGQQGLQNASQTGASYLERAKQEAEHLRQQAEQLREQAAAEASRRYQEADKLAHDAVAAAQEKAAAAQAAVTGALSRGQEQVQQNATHYQAVATGKTVDGAPNANITPLPVSEAPAADRSGVSTSKEGPTVPGAEITSLPASEAPVAGQGSNALPSEANAVVPAQPSSASSSGAPTSAPPASELPNLPAREITPLPASEAPLAEKNVTHAFDDHPAAKVAAAAAGVASLAAGAGVAGFASAAPSYTRAASSTLTQGSLASPPSSNTPAVEVPHKVLETTPASDLSANRTSWAQSQLSNAATTPPLGVTRTSSSYATSALTPSQEAARAAPGTESYAEAAAPSAGGSTSGNAQGARDAATTGAVRSSTYAVPDRSTYEGGSLSPSAMKRASNADLPPPVAEASPPLASRTSSEKALPRAPSSQTKPGPALKEEDTYVAHAGAPSTIPAPSQPSTPSKREEQFTTAPTTPASATVVGRHGGVTEPTGSASSSAPASPSVASDSGREGGKKRGFFSRFLKKDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEI5</accession>
    <name>A0A2S5BEI5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cystinosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEI5"/>
    <dbReference type="STRING" id="741276.A0A2S5BEI5"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30662" checksum="ABF25A0DF4437E25" modified="2018-07-18" version="1">MVVFWAQLSTILGWTYTIIWSLSFYPQIWINYRRKSTTGISMDFLCLNPIGFACLTTYNLALYTSSTVREQYAARHDGHYPQVQPNDLAFAVHALLLSLVILSQTLIYKRGPLHQLSRFHRAVILLILSTISITLLLAWSGWVYWLDFILVLSYLKLYVTAAKMIPQAWYNYQRKSTVGWSIENIFMDLSGGILSLIQLVIDSALDHDWRGITGNPGKLGLSFLALGFDTLFLVQHYVLYRGAVHEDENVTAESSERDRLLAQSDAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEK2</accession>
    <name>A0A2S5BEK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEK2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="329" mass="36524" checksum="22F59951FE8C4FC5" modified="2018-07-18" version="1">MPLSSVPLPTHSLFSPADPDIKAHIAVDGEPLEVVYKTDSSSSGTRKLQGYIRADPGRNFSLCLYHGRQSTQVKGLKWLCLHREGIRLRMNLTRRLCFARVDATANDDEVNVSTYTELDDATALEFKFYWVKEARIVPGDAAVDDLLLKQRKEQLRAPEDLDKLKLPMQPSFGPIEKQTSAAASKQVWETTLEDPHNPFATMKFLLRSEPVFDRLKLQGETVTLSRTFTPPLVIDGTVYLDLSPNEALAEARAGEKRVKAEEPDNSPLGRQRARQHEKTPDGDSKLGRYSPDALQTPTRPAPNGILERAVADAIAKVLPGVLADMCVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEM8</accession>
    <name>A0A2S5BEM8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEM8"/>
    <dbReference type="STRING" id="741276.A0A2S5BEM8"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="67467" checksum="B7E5C3761558BAC2" modified="2018-07-18" version="1">MVDLAHNAIPPPQPPLGISTERPESFSSTEEVPVGSFDDDKLAKEYATESEASSLYDKHAAGPLAPADQQPYTAGAAILHFLHIRRRPKDYDLDAVATVESVFDGPLGAAYVPNERYENKDAFDPAFRWTKREEAAVRRKIDLKIFVWCLIMFLALDIDRGNGADNLLHDLKLKQSDYNLGNTLSKIGFLVAELPSQAIGKKLGVDIWLPIQICTFSVLSLAQFWMKGRTSFLAFRFFIALAQGGFIPDVILYLSYFYSSYELPIRLAFFWSINYLASTVTAFLAVGLLKMRGIGGHAGWQWMFAIEGALTAVVGVASFFMLVPGPSQTQTRWRPKGIFSEREVKIIVNKVVRDDPSKATMHNRQALSPSLLLKSFKDFDLWPMYLLGLTYGIPGVPLQFYFQISMKQLGFSTVMANLLSVPNTVWSIMNLLLLTAATEIFQNRWFICSLENWWWLAPFIALVAMPSISPWIYFALATVILSFPYAHAAQVGWASRNSGSVRTRTVSASLYNMFVQASSIIGANIYQASDAPRYRKGNAILLGITAFNLLLMYPGVGAYYKFRNRQKAKQWNALTTAEKRNYLETTTDEGCRRLDFRFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BES0</accession>
    <name>A0A2S5BES0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BES0"/>
    <dbReference type="STRING" id="741276.A0A2S5BES0"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="5">
        <location>
            <begin position="128"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="501" mass="55624" checksum="237FB7B78EFFAA0C" modified="2018-07-18" version="1">MLFRFGQSHRVVTRTLGRISCSFNTTTAARPLPLLPTQLHRSRQPLRTLLARQFYSANSLLQQATQDQTYPDHVYASIAPEATVPYAVPAPSRDFDFLPNRADSPKMVKPIQGTQYALDAQFKKISRDFRTDTITMPTEEMFDLMRHASRGDDVYGEDQATNDLQDKIAKMAGKEAGLFCVSGTMTNQLAIRTHLTQPPHSIILDARSHVHLYEAGGVAMHSQASSHAVPPKNGHHLTLEEVLDNCVFGEDIHSAPTKLVSLENTLSGMVFPQEEIVRISDCMRSNGIIMHCDGARMWEVAAKTGMSLEELCRPFDTVSLCLSKGLGAPVGSVLVGPRKFIEKVKWFRKAFGGGIRQCGSLSVSANYCVDNHFPKLKATHELTSYLAKSLAELGAQLLLPVETNMLWLDPSSLGFPITVLAERAKTRGITLGSNRVVVHHQVSREAVDDLIQLVADMKDEFKDQPKREIDQEQNMLYAQGVYQRPIEPPIARLGTSYGKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEU9</accession>
    <name>A0A2S5BEU9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEU9"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="317" mass="34672" checksum="A28576B8F2802320" modified="2018-07-18" version="1">MARATSDTAPAIVFLLLYLAVFAVLARLYATKAVKWRSRYSFVLFHVIMRVTGMALGVAFSCLSWEQERQARTGVLIAYLVFAAEGYFSLILCASRFLIVWQQDRLGRSELEPRIPKGTPTSERIKKLVAAPILWIEYQLAAANAIIVAGSSIMSQSITNPDSPDAHSKSTTGKAMRIAGTGIFLGLVQAIIFIAILSYRKRGDRTLVMILLTWPFLTARGIYGILSVVTPGWSYSNAAAYGPNGFTSNFLAAEYAMGIATEWVTCVLLLGTHFSALNGGDELVEDHNAEDTDKLRMQSLGDVETSRRSSVGARKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEZ8</accession>
    <name>A0A2S5BEZ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEZ8"/>
    <dbReference type="STRING" id="741276.A0A2S5BEZ8"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="203"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="440" mass="48192" checksum="21261F4E0F420D89" modified="2018-07-18" version="1">MHRGGSGHSSYASSQERRPSTTASSQAPPTMTAGGSTLSFESVEQYDYGTNSWTAYSTPHEPVAALAGTSLSGYAGCPPPPPPHGGQAPLSFSYPPHQPSHHAYGMYDHSYDYNNDVVLAAVESARWEYQTAAGLDQQQGSHIDPSFQLPPAVQPPPEPALHVEPVKTRQPRTHRRHRSDEAPSITSSGLALPAATDDSTHVEVKPFVYKIFSMLADPDRYQDVILWDHAGEAFFVAHNDRFVNEVLREQFQHTNIHSFTRQLNVYQFQRYTVAQLRSSLDLSGAIASTYSGWTHPQFKRGRPDLLPMLTPRPSRARLIRKLEKQYSKDGSLSPGKNTIKLPNSGRRGSSAGTSTSSSKAGSDTSPPVPNAYAPLPIDISSTFTPYTQDITYPQILQHQQQQNLAIAAASQGQPMQPVFSLGFSFPHAQNAQFKSESPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF20</accession>
    <name>A0A2S5BF20_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF20"/>
    <dbReference type="STRING" id="741276.A0A2S5BF20"/>
    <dbReference type="OrthoDB" id="2530177at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="915" mass="99220" checksum="93477D631025F305" modified="2018-07-18" version="1">MAGEARRNEFEHLLPISQPWGEDSTSQADPSSSQSIHATQPAAGGGSDYEDGANVRQAWPDEYWRLPQLPVSARGGPISYDPEVAPTVSPTSESDFTFTRALPYPSGLPALGVPASYAGNTAESAASDKRSSWGDAERKKSLRLAPGTPGSAFEYRPPWGQSLLDLSASRTTEAEYDDSVSSSARWQAPPVPPSLPVPGSSALVRQASWPLSFLTTGTPTSSSPPYSPARAYGNGGTGPLSHLHGQPGLPRPESRPGPSGYVHAPRARSFTTYQYDPSVQLGLSTRSNAPSSSASSYAVPAAPPSTEAEGSTSYDDFSFLSTSLPFLSTTPALPTVPAGVAFPDKQAGMTYPIDVSTPYIPRRGPGYSDAVIRAAAYRQSIGKIDLTGRFSENQPSRRVPTSQSVRRLVDLGVTCLACHRSVARLSLRGGQVEQPVGDDPSKYDAAFYCTTCVPLPPYLGQSARGTGVFGHEDPYAGECTYYDSLSCAVDRYLGEDVEANDTRPPPVPPAKARLGFVPYDVAPEPSKKRKDKVVSEVEGMLACDVCRRDVGSGQLRLAETGEAVGSTIEVLCAHCDTRYLRCSDCGGGGGNKGVGRWRCKELFPIGRKTCQLPHSRLGLVDEMDYDVWPLETLTDEERDLLNTQCCNLQTMYILAALAVPDMLESIVPLARSFEEVEKLTVDTWGFLSVMHEPSDPASGVRRYLAVRWVNPMSRKKRSKRGPGFRSDRQSSSDDQRAPGAPLTPQPAMPIRSGKNLTGFVSGEYEIEKGILHVGVAVPTGAGEAFEATSRLLQSMIARVAEDAIRLNAQRAQRNLPPYPLLHTAWTLHMTKRDSRIMSRLETRRGFVPLEDFLLKYPEVSIENFPPYRETYLQPEFLRGFMVWVKAIRVEDLPPDYAGPALAAVEAVQNGRPPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF25</accession>
    <name>A0A2S5BF25_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF25"/>
    <dbReference type="STRING" id="741276.A0A2S5BF25"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="191" mass="21989" checksum="E7BBAD8EEF9B4D60" modified="2018-07-18" version="1">MAQEDSAPLHEDQQKELDRQNAEREQREQAALPYRWRQTLQDLTLSVPVPSGTRSKQLDVVIRKQYIKVGVKGEPAVIEGDLPQEIKVDDSTWTLDDSREVTVSLEKVNQQSWWPHVVTSAPKIDTTKITPENSKLSDLDGETRAMVEKMMFDNQQKQMGKPTSDELKKQEMLRKFQEQHPEMDFSNAKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFG2</accession>
    <name>A0A2S5BFG2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFG2"/>
    <dbReference type="STRING" id="741276.A0A2S5BFG2"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="608"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="966" mass="105395" checksum="EE52B6774CF44DF9" modified="2018-07-18" version="1">MRDPPEGLALASSPASLIASRQGALCGQARTRSADAVDTYLQYMARHHRSKHSKETPFSCEYCSRAFSRRSVGPLSESVPPESRHRLIASMSNSDLLRRHYKTCAKAKGSSAARDVRESASPNEPVASGSGESAAPTRAQMPVGYAASHTSSSASPYDGSDFALPVPPATFGQGHSPPGFDASPPESRHSPLYSLSPYSLPTNASTSTLATSNGSPDFSSGQKNLYSAASTPPLALPAQSTILPPLSSLHPQFQSAMLPLSHTGHAVSAYGQQLPPLAGFAHQYGRQYAPPVIQHPQAQQRLQSPSEAPSQPQTSAPASNTESEETRIVAPAPVQPTSAFKFGSFSQDTLAPGLSGTGSFTKDEVLASEVLRDLMRSPLGPQHVTPMASPLSETPWHGAKAASRVQQQGRQEGATDDEVMRGNEAVTLVDGQDWTVTGYGAAGVPSLQVSNKLETSPAAQALASYFNQGGVGGITALDLGFATEPSLFPDFLLQPQIIHEEDRRYWLPEQKFCIGYLFPWHVLSGYARKATEKLLPSMPIIHAPSVNLNEMATHTAFALTVAGGAYEQEGQSFSNEMLVEKRVFLVRGELPSFRDRAEAGSLTGPSSRWTGFQDTSKTFEEKFSSMQSLLLYQLLGLFHRDEQQRLLSQSFHSALIFMLRSLDIPAKIKSTNVSAPRPDLEGEELERAWKEWIKVETWRRVNFIIFLADLEYASATKSAQLLSLSDMDLDLPSGDRAWNAKSASEWLEHMLSPFAPPAHSYLATLRALMSRSEPARDPFSEQAVLLAELSRISSFPLLILSRTLSFLEKKTEEAIDQMDPFRKYFEGTNVVDSRDAENRDVLGRIRSGRQLPGGLARGGGERWFEEVIPSAPGYTCSHPCSPSSERTPAVVPPNPQGDMSTATEQQTLEEMFAEFDPQPYKPAYGRGGTKQHETYDEAQAQMHLLTESKLQSLRDNYPQFLQQQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFJ7</accession>
    <name>A0A2S5BFJ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Organic hydroperoxide resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFJ7"/>
    <dbReference type="OrthoDB" id="60422at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797:SF2">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18018" checksum="0C951FADA1422FED" modified="2018-07-18" version="1">MLRSPITALARTAPRFARGYAKVAPIAVSRATSTGSRAAGTIKTDQGLELKTDLQKELGGKGAHHNPEELFGAGYATCFLSAMGATHGSLHKDAKPLPKDATVEALVTVGKDAEEKIPGFLLAVELKVHAAPLKQIGLSDAQIHKLVEESHKVCPYSRATSGNIEVKLSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFW0</accession>
    <name>A0A2S5BFW0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_1277</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFW0"/>
    <dbReference type="STRING" id="741276.A0A2S5BFW0"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="6"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="402"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="894"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="450"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="520"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY75655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="949" mass="105586" checksum="F5812346BBD27E88" modified="2018-07-18" version="1">MSATANVKVVCRFRPPNAIELRESGGETIVQIDEDGTNVKLRSQEAMKGPEAQGFTFDRVFQMDTKQQEVFEFGVKDIVHDVMDGYNGTVFAYGMTGSGKSHTMMGPNIDDAEMKGIIPRITEQVFASIMTSPANLEYLVKVSYMEIYMERIRDLLSPENDNLPVHEDKQRGVYVKNLSEFYVSNSSEVYEIMRQGGSARAVSATNMNAESSRSHSIFVMTIQARNTETGTQKTGSLFLVDLAGSEKISKTGATGQTLEEAKKINKSLSALGMVINALTDGKSQHVPYRDSKLTRILQESLGGNSRTTLIINCSPSPYNETETLSTLRFGMRAKSIKNKARVNAELSPAELKALLKKAQRDNANSAAYIGLLEQEVATWRDGGKVDPAEWASMERALGLGEGELEKLVGPNGARSNGRTTPRPLALDRLSEGGAIRPDTPTSTALGADEREEFLKRQNEMEDQLSKTESELSSQEKVIRDLREELSSLKESESSALSDSKSMGGELADMRLQLERLRYDSKEAAITSDSLKEQNAELERELEELRRALADAKSTQKSVDQEGKDKKKAERMAAMMAGFASGTMSEAETEIRASLARLEDAASANKALSPEEVAAIRRQLEDSTLTVREQAERSKQVHEENAHLSKRREELEARLATIEQEYEELLDKTMADEERADADHVQDVRNKLEAQYVMKLDAAVNDLNDLKQQLELRNQEVRAAQSSIEQLRTANAELERTFKITTASIEGGKNLEAAAKDLERQHKAVAQQLADFDAMKKSLMRDLQDRCEKVVELEISLDEARENYRNLAKNSNSKTQQRKMDFLTRNLDQLTVVQKQLVDQNSTLKRDVALAERKLVARNERIQNLEALLQDANEKVNQQNAKFEARLQAVRERLDQARAAQNQQPAPVSNLNFGRIAKPLRGGGADGEATSPTPDRRASGFFARFGSPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG73</accession>
    <name>A0A2S5BG73_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG73"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="210" mass="24520" checksum="8D84A0A84067C0FE" modified="2018-07-18" version="1">MPASYSVRPDVPGQVKHKPGSLYDVPYAYYFNVYRGFGRFMEQTAGPILEEQHLHYARGPQPKYTWEQKEEARSKTVLPGRRFLHADQYEALPEEERRKLYLDGVANLIKVANPTYWNFAAIDACWKLTFRDRKMLSPTPPSDSTHEQDVESFDLQRRELVEHLRAYYQAPFLRAVEHAPGIHEASTRTEFHALARSAHPRRPVVLLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGG4</accession>
    <name>A0A2S5BGG4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGG4"/>
    <dbReference type="STRING" id="741276.A0A2S5BGG4"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="205" mass="21515" checksum="668EAF3353EED7D0" modified="2018-07-18" version="1">MATEPSTSESTTAAASPQPEPGASGAAAPRPPSAAPAAPAAPAAPHLLDGLSPTDLRIKLDHARKGLRQHLDKKRKLDRELAQLEQSIYAFEGSYLSDALFPATAANTAVGGSGGQAGAAAAQFGNIIRGYDSYLKAPSASAQDRKRFRPGDPPSDKERMFSASSATFHRSVELRAAETAASMSVEPESDDDYGTSSRRKQRGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGG7</accession>
    <name>A0A2S5BGG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGG7"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY75868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="228" mass="24611" checksum="43E754F0887F0950" modified="2018-07-18" version="1">MEPDPIASTSQAPQGAPTAALPVAAAAPVPLGRRAKLTQDALFAASNKVIKVLDDKAMRQCFPRTWNEQYPDLIPGLKALVVATYTEGVPLAWNDLAQSADFIAKANELDRLLEDAKARKARGEAPRNAYEIGLDATVTTPSATAPRLRSAIEELREKRRALSEQNAATYERIASLSQTATSLERQNDEILTHFTQSVAALKEIDEESLVALQDELVKVVGPALANAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGV7</accession>
    <name>A0A2S5BGV7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="3">1.1.1.271</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY76001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGV7"/>
    <dbReference type="STRING" id="741276.A0A2S5BGV7"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="327" mass="36813" checksum="4B48D08657A82F30" modified="2018-07-18" version="1">MGKVILVTGGTGLVGRAIEYTVKNEPVGSRFGTWSQDDQWVYLSSKEGDLRDLKETMAIFDKYKPTHVIHLAALVGGLFKNMKYKLTFLRDNCLINDNVMWAAKEHNVEKVISCLSTCVFPDKVTYPIDESAVHLGPPHSSNFGYAHGKRLVDVYNHAYHEEFGCNFTSAIPTNIFGPYDNYDLEDSHVIPGLVHKCLLAKKNGTPFTVSGSGTPLRQFIYSRDLAKLFIWQLKEYPEIDPIILSVGEKDEITIKQVAESIVKAVGFEGEVSWDSSKADGQYKKTASNEKLMKYLPDFQFTPFDVALKESVDWFVENYDSARTGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGZ9</accession>
    <name>A0A2S5BGZ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGZ9"/>
    <dbReference type="OrthoDB" id="2530475at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="122" mass="13796" checksum="4EA661ACC6A9F19B" modified="2018-07-18" version="1">MSCTTDTYFVYGITVTHESLVYAAMAYPNLEGPFRFFHLMRNRARRGVLARPGDSMAARVPVELRDEIGRELAAKEVWAAKSRFAKEQLSSKHEGCDDYDCCCHDSEITWQGNAAVYCNFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH09</accession>
    <name>A0A2S5BH09_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH09"/>
    <dbReference type="STRING" id="741276.A0A2S5BH09"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="74"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="240" mass="26380" checksum="82E1AEEFE961192D" modified="2018-07-18" version="1">MASTAATRRTATALGRRATLACSRSFFSLPTGFPSPFGSASSKPAPERKGTLVKEGGIWVYREDKVMPKTDGTSYSPAQLYSVIADVDSYQSFLPFTTSSRVLTSAAIGPDGSRRDRPVAEKGWLRPGSGERWEMDAELRIGAMGFEEGYISRVEAEKERWVKATSKDASMFRHLATIWSFAPTQTSQPSNPQTKVNLYLAYAFASPIHAAAIQTVWDKVSALMVEKFEQRVKQVHGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH86</accession>
    <name>A0A2S5BH86_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH86"/>
    <dbReference type="STRING" id="741276.A0A2S5BH86"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="121"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="279" mass="30355" checksum="D5F7460769C154B5" modified="2018-07-18" version="1">MAYRIARTAFRPAARLLSAPAPVPARIVASALSASSAHSSPPSLTFVRTKKTKPSKQTEDAPDGGRGSAGKKGKGKGKMLTEDDLLERQLPGEHFELKVLEERMQEAIDRLRVSLNAVVGRVGRITPALLDGVKVDTPEGKRPLLEFANVSVKDGRDLLVTCYEESSIKAVSSAIYASPLNLAPQPSGASSLRVPVPRPDLDKRQQYVRDAQALCEKARNTIRAHRVDGQKDIKKDVDAKVVGTSEARTEGKKLDDATKKKTAEVDKIFEDVKRVLLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHL4</accession>
    <name>A0A2S5BHL4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHL4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="24" mass="2701" checksum="30D6F15A571A8984" modified="2018-07-18" version="1">MVEEIQQDAPLARTRPDSETITLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHN8</accession>
    <name>A0A2S5BHN8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHN8"/>
    <dbReference type="STRING" id="741276.A0A2S5BHN8"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="339"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="430" mass="45733" checksum="CEB887E1A8A9A64D" modified="2018-07-18" version="1">MLSRNALLPARALTKAVGRRAASSSSSSVKRTALNGFHKANGGYMVEFAGWEMPLRYEGSDASKFAGGPVAEHHQVRKSSGLFDVGHMVQSTFTGPGAIGFLSRLLPASLSTLPVPGEDAHRPFGATLSVLLNEEGGILDDCMITRWGSDSFYLVTNAGRSEVDIPWIQKHVEAWNGENAEKVEFKIMDDAALIALQGPESHAALQRLLPQDLSVQKLLTFGQSLHLSLPSLSSSATVHVARGGYTGEDGFEISVPNAHAENFANMLLDQPEVKLAGLAARDSLRLEAGLCLYGHDLDETVGVGEAGLAWVVGKDRRTPGAFIGSERTLAELKKGGTTRKRVGLTVEKGAPAREGAPIYATADASSAPIGRITSGLPAPTVGQNIAMGYIATANGLNKKGSQVFVEVRKKMRKAEVVGMPFIKPGYYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHQ7</accession>
    <name>A0A2S5BHQ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_0479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHQ7"/>
    <dbReference type="STRING" id="741276.A0A2S5BHQ7"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="146"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY76284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="469" mass="51275" checksum="6D3C0E6BD5DD4913" modified="2018-07-18" version="1">MASRVTRSASKATAKAASPPASPAKRPRPTSSSSSTAKAGSLGPPATPKRTKVQHSKVPDSPYVPPTPGTEQKIHEWVESAEKEGEKEGAVLLHPELTFKFEDAREHLAQVDPRWRTVMDQLPCKPFQGEQKEPFNPFRSLVTSLLGQQISWLAARSITHKFVRLFFPHLPEKLPPAGSTEPKLETPFPTPHQVLDLPDRTAALRGAGLSGRKVEYVVELAERFADGRLEAKKLWAMNDDELMETLVAVRGIGRWTVEMFLIFAAKRPDVLPCGDLGIQKNLCKWFSQDPSYAPSIHPRKLAGASPTKLASSESAQGRNESESPQKPSRSEKAGSKSQEEEVADAPATVPSERAHEGEGAGIGKLGAMGGAAVEQELVLDLDRPDEGVKQEDEAGDDDKDDAKEVEFVFPETSNNLTPAILRSRLNGKKLKGNIYMTPGEMEEMTAAWSPYRSVACWYLWSITDGTGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHU9</accession>
    <name>A0A2S5BHU9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GET1</name>
        <name evidence="10" type="ORF">BMF94_0547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHU9"/>
    <dbReference type="STRING" id="741276.A0A2S5BHU9"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015454965" evidence="9">
        <location>
            <begin position="17"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="3"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="164"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="212" mass="23300" checksum="096E60771F05C89B" modified="2018-07-18" version="1">MELALWLLLTTFIVEAVGWIGSDVLANLVYTPFAPAGKAQKQQKAEILKLRAELAATSSQDEFSKWARIRRKLDKAVQDLDASNSGSTAQRQQFASNFKRALWVLTTVIPFIISSYHRKSPVLYLPRGWFGPLGWWLSLPSAPAGAVAVTVWTMACRRTIQSVKAAVSELVPTPVERTAQQFAAEQAKAASVEKLKVGVTASGSEEKVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI64</accession>
    <name>A0A2S5BI64_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="8" type="ORF">BMF94_0667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI64"/>
    <dbReference type="STRING" id="741276.A0A2S5BI64"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="317" mass="33764" checksum="C68D6AC423A50A92" modified="2018-07-18" version="1">MTATAANGQPAFPRSFSLQLAPGTVDAFPPSSPNRRDAAPAAAAVTALLPARVYPHKPRKRWLTRLRATGTYALFLLIFVALLASLVDFGHSIIYSDRSSKASDLIIGFGSYVAVIVFGIGMAVARRIANNRAEAAIPKAYVPIQVEDVPKRAYRLIKSEFDRACIITKVHQPRGRSQAGWGRPGTASENVHFRSAILSTVPALRAALEPLLATTSTRARSLQWAELGGGARSGPISPLAPLLLDTDDDAGGALIPDALHPLAELYERHLVKAKYAKEEPTEQEWDEAVKAVAVFVGVLTTTTTTAAAKAAAALDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIT7</accession>
    <name>A0A2S5BIT7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIT7"/>
    <dbReference type="STRING" id="741276.A0A2S5BIT7"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="104"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="483" mass="53117" checksum="54B5C68C8BDB9F11" modified="2018-07-18" version="1">MLAALRSSVSRTAPTSRQHARSLASSSRRTSPANSQTVVAQPPTVANSSLLRTDRAEALWTPGLRWQDEEQVGVGFPKGRQQDREIKETDLADVEAGGRATEKLNMYQAIRSALQIVMQKDPTSMVFGEDVSFGGVFRCTMGLADQYGSERVFNTPLTEQGIAGFGIGMAAMGHTAVAEMHRPKGGAIDLFSRWDRFADYISVSLTCGPQRLDTPLRLSISNSAKYRFRSGGMFDCGSLTFRSPCSAVGHGGLYHSQSPEAYFLQASGVKIVVPRSPIQAKGLLLGELESARTAYSQHALIRVIAAAIRDPNPVLFLEPKILYRSAIEQVPVSDYELPLGSAEVLQEGKDITIISYGPPLYTIETALHHMRHPSEDLQKLIPQDMRGLSVELIDLRTIVPYDIETVVKSVNKTGRCMIVHEAPSAGSVASELAAEIQQRCFLRLEAPVKRLTGWDTPFGLAYEKFYLPDQIRILDGIIETMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ30</accession>
    <name>A0A2S5BJ30_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ30"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ30"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="433" mass="49740" checksum="A6F4FD6A6EF9E4A1" modified="2018-07-18" version="1" fragment="single">PLYQTDSGRLWHAGQILLVFVGLPARGKTHVSRSVERYLRWLGVRTQVFSLGDHRRRLLGTSADLPPDYFDAEGRSPETDKLRTGVRLSLEDEVAKYFRDNIGQVAIFDANNGTKAARIALRQKFEAQGVNVFFIENICDREDIVEANIRSVKISSPDYAGWNPDDAVKDYMSRITAHAGKYETMETSGGPFVKIYNIGERLVVNNIRGYLQSRIVFFLMNVHHKKRTIWFARAGESTIDHSFKADADLSEQGKVYAQKLRDFIVAKRRELLEERAKAGEQGHERRLTVWTSARKRCISTARPMAELGYKVVQRQQMYELNPGDVDGLTPEQIREKYPEEWARAERDPYAHRYPRAESYHDLSVRLEPVILELEREPADILFIGHGSVIRCIMAYLAGMTPHEIPKVELRRGDIVQVTPSAYGVKFINHFFWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ44</accession>
    <name>A0A2S5BJ44_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein mS38 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ44"/>
    <dbReference type="OrthoDB" id="2527129at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="3">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="471" mass="50269" checksum="E07A3EC6D8A92F98" modified="2018-07-18" version="1">MAMVPARVPRSVQPVTGLRLLTRREGATRPYSSSSSSNSNGSSAGRSSSRDGTPRDAAVAAAAASAPSTSTVSAKASTASEPTAVARSLSPGPTHAKKRAPIQPQQVNKRAFELPHVRKGVVGLDTFFATHRPLLELPLRLGARRSTTQGGAHDSAYVPKDGLGMATRGRNGSLENELVEVVDQAEDGTSVGEPYLVRLSEPEPLKSVEEELAAEAVEEAELAQQEEMQHELEATEDRPYEPWLLGQMHDEAARTPDVARYLAVRPPFTAPAPSVAAASTSSGAAASSQTLGFLAPFQSSAAQSSASSAPASTEYSSTFSSHFVEPLSPNEATGAVDRFLSHHEVLYRWAAQTDFVNAAGEALRRAGQTYSTSSASATATELGASKSSAVLEALRQQRGSVRLWTDADGYFSVPLGLTAGLTPSPFLPAEDVIVEDIRMDSVKRKRQKKIRKHKHRKRRKAQRALRQKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ95</accession>
    <name>A0A2S5BJ95_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ95"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ95"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1067" mass="108650" checksum="F18F672116B9055C" modified="2018-07-18" version="1">MAADRLTVDAVPLPSPSAFPALSPTSHASEPLQHSAAPTTDHAATTQSALSYARASSSNLPPTKAPEGVSLPPAPHSNLPATANGNGGGGGDSSPTGSAKGSKERPQWVRPDGHASEKPKGPVKPGNHRLAAGGGPGPRHSGAAAGGGHSRQPRQSNGHASAQNGHAEAEPSGAKRPRTVPGMPASMLPPVANKKAKHKSGNATAPPPAATANDGGQQASEIPAIGKKRRSNLRKTLPPTASKLSALAASFDFVPRGDAPSLPAPITTMSQSSPPTAAPAPKEDKSEDGKAAPADSSTAEDSTEASPKGGAETSLLSESESAAIRDTVGSAGAQGDEFRSQTFSAADARGAVEAQGTEPGLQSASAKKPVAAGSAPEPERHGTEATKATLSVVETHESSLGGFLDQAFVEANGEFAPLDLPQTDENAGEPAAAAVFNQVPITRIEGAVDESPIADLSWREKKGWWSDDYDGISASTTPVLPPSPEANDDEVDPTKAGPAAVEPAQSQAEGAEQILMRLPPWKPELAKGGEASAEEQKPAKEVLAEGEVKPLVEFLPKAFVAQPDDDAEKADESEEAPVVSTSRSGSSSALSSFLSKSFSATGPPTPLEAPATFGEGEDAAPLNAEAVVAEKPLADILDVDAIENGKVVNESAAESKPKKHGWWSSGYVPPEEQQRPSGEGLVDEKLVQETVGSAGAQGDEFHARSYSEADKAGIEEVEPTPASAQSAASTPAEKKEAAPASCDALKATPRSSESSAASSSTGPSKEAPKEQKGDSAAEPAENRPSTPIGQFLNQAFSAKSDQLVSEDSETKPEHQDGTGLVDDRLVQETVGSAGAQGDEFRAQSFTSADQQGVEESTPVPASAQSSASTVSEKKAADAGETSISSSANNKQGSTSANSTPRASPSAETLPTITANTPVALRRRSSSSSSTPPPTPRRSASGDADKPHHSADDAPSLTLAIASAWHTAPWTRKLWAVLASVAINIGLPFVNGVMLGFGELFARNVLGVRLGWPLASSGQQQGSQRANTGSVGLRAAGSRANVGREVPGHAGAKTAAEAAVEGARELAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJA0</accession>
    <name>A0A2S5BJA0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_0090</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJA0"/>
    <dbReference type="STRING" id="741276.A0A2S5BJA0"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="14">
        <location>
            <begin position="354"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY76838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="463" mass="51869" checksum="2A46DE0B2231C1CD" modified="2018-07-18" version="1">MSKLFSPGTRFGTWRKLWLSLATAEKQLGLNISDEALEQMKANLDLDEEQMADAAVEEKKRRHDVMAHVHVFGQRAPAAAGIIHLGATSCYVTDNADLIFLRDACDIILPKLAVVIERLARFAETHKDLPTLGWTHFQPAQLTTVGKRATLWIQELLWDLRNIQRARDDIGFRGVKGTTGTQASFLALFEGDHDKVEELDRLVTELSGFKHAYPVTGQTYSRKIDIDVLGPLASFGATAHKIATDIRLLANLKEVEEPFEKDQIGSSAMAYKRNPMRSERVCSLARHLMVIQQNAMMTASVQWFERTLDDSANRRITIPEAFLTADVILTTLQNVTEGLVVYPAIIARRVRQELPFMATENIIMAIVKKGGDRQVCHEKIRVLSHEAGAVVKQQGGENDLIDRVRADPFFEPIVDDLDSLLDPSTFVGRAPEQTTKFVNEFVKPAIEPYRRQVELSTAAELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJD9</accession>
    <name>A0A2S5BJD9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="6 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_0135</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 19">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="6 18"/>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJD9"/>
    <dbReference type="STRING" id="741276.A0A2S5BJD9"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 20" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="26"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="66"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="376"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY76883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="421" mass="45107" checksum="AB644ACB81EC7583" modified="2018-07-18" version="1">MPASLSSKLSIKDVDLKGKRVVMRVDFNVPFDGEGKITNNQRITAALPTIQYAIDQGAKSIALLSHLGRPNGAVVEKYSLKPVAAELERLLPGKKIQFLPECVGEKTEQAVANAQDGEIFLLENLRFHIEEEGSSKDKDGNKTKADAEKVKQFRASLTKLGDVYVNDAFGTAHRAHSSMVGVDLPQKAAGLLMTKELEYFAKALEKPERPFLAILGGAKVSDKIQLIENLLDKVDSLIICGGMAFTFKKTLENVSIGKSLFDEAGSQKVASLVEKAKSKNVELVFPVDYITADKFDKNANTGTATDKEGIPADWQGLDAGEESRKLFADAIKKAKTILWNGPAGVFEFDKFAGGSKATLDACIEAKNNGATVIIGGGDTATVCAKYDAEDKLSHVSTGGGASLELLEGKDLPGVSALSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZN7</accession>
    <name>A0A2S5AZN7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000155">
        <property type="protein sequence ID" value="POY70000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZN7"/>
    <dbReference type="OrthoDB" id="2552817at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="17821" checksum="42754F5F0EAD1AD1" modified="2018-07-18" version="1">MSSTTQELSNKAGNATNGAVGEQTLVNEAATVASHTLDYAKGLVGLGKDKGAQSADDAANSSHGAEGSHTLGGIVSETRDLAAHTLHAVSDLIGTGADKAKEAASDAQASADAGQPKGYVAAARDTAASVLQQVEGLIATGQKKVEETSSQDVKSSVNSAVDQTKAAASDVKQSASNATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZN8</accession>
    <name>A0A2S5AZN8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_6987</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="PJQD01000155">
        <property type="protein sequence ID" value="POY69997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5AZN8"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000022">
        <property type="entry name" value="Blast:Putative DNA helicase Ino80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="19">
        <location>
            <begin position="435"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="700"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1281"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="260"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="336"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1455"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1455"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1531"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1581"/>
            <end position="1604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY69997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1611" mass="180509" checksum="B14F7DA1CFBFC8C1" modified="2018-07-18" version="1">MSSLSHLLDGPNGVNGGIPPANTVPMNYGSAPPAPPRPKRKRPSRAAAAFIDEEDIATRRSSLRQSTRPRRYDDELYDDDVGLLGLERANGRETAAADPADNLPSDEEGDGLLRATSHIWREPLQAYVSELHTRRRQVEQDVEDAEASRKFVVAARAVEFAELRIPAMRERQTIRAVQVQQEPDAQAREAAVAAEKTYIEEIARPKRDADREERLRKQREAARKKREEDRQKREHDNEQRRLRAEEARVAKIREAERYAALTPEEREAEDRARAEKLAQEREATAARLREQEEELMASGRGARKRRKAGDDLEADALDALSSFGMYAELDELEFDDSGLYDSHGGKSRRGKGGSRRSSSFAPDAGGATALPPGAYSGPDGQLYDASGVPIEWPPAGTSGSPYLPDGTLDADGDGEFVKTTSKKRTKTVEELEKRLWTQIARRDIPKVHKIQQQSSSSRQFFNKRISSVVAREARRAAARTKSTKDIQTRAKRLMREMQMFLRGNEKREREARKKAEKEALEKARREEEVREAKRQARKLNFLITQTELYSHFVGNKIKTNEAEESADTAAEAKPTAQEPSAALVAAMNAKDEGDLRDLNFDEDDEENAARHAKRNAQAAIDAARNAASAFDAAAKVANASGENGETPAATASQHAPLDLDGAELNFQNPELGGDKVVVTQPKMLACTLKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISLMAYLAEVHDIWGPFLVISPASTLHNWVQEITKFVPSLKALPYWGTVKDRQVLRKFWNRKSIRYDRDTPFHVVVTSYQLAVADEKYFNQVKWQYMVLDEAQAIKSSGSTRWKTLLGFRCRNRLLLTGTPIQNSMHELWALLHFIMPSLFDSHDEFSEWFSQGIEGGSDSKGGMNEHQLRRLHMILKPFMLRRVKKNVQNELGDKIELDLYCDLTPRQKAMYRTLKENISITDLVARASNLNDDDSVKRLMNLIMQFRKVCNHPELFERADVTAPLAFATFNKTASLIRDPEVLDVPYATHSVIEYQLPKTVYREGGLLHVAGPKSRAGSDSLHLARLMNIWQPDYIQRSLHTQAPYSNSDSPFQFSRHLGLSPGELHSAVAAHGIVRLGLSLARQRAMLTDIAYQTAHEEDEAPLRLVVPDKASTMPAITSGHDLGLTPLGGVESAYRKSSPLIRPDARFYYDPAVAPAISAHCSDRSFAYEDEAERFDPLFHAAFFGLPASARESLAAVRQSDAEMPGLPPQGILDVSDLAQLPLPSMQVPQLQKLILDSGKLAKLDSLLTQLKAEGHRCLIYFQMTRMIDLFEEYLAFRQYKYLRLDGNSTISERRDMVTDWQTKPELFIFLLSTRAGGLGINLTAADTVIFYDSDWNPSNDAQAMDRAHRLGQTKQVTVYRLITKDTVDERIVQLARNKKLVQDAVVGSSGAAPPSEGPAKANEVVSLLLNDNELEESLRQAEERRKRNEETKREDGKRGAQTRQVNQAKKRAAAAELAQRPPAWEEANEDEDGMSFFANVNQTATNDDDTDQPPASGPASGAASGTETPQTAPEPKPKAPRKRKPDFDENGNPIQKRKRRSRAEMEVFRAEEAERKRLREEERLAKKAAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZP0</accession>
    <name>A0A2S5AZP0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_7019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZP0"/>
    <dbReference type="STRING" id="741276.A0A2S5AZP0"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="261"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="426"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="639"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY69975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="844" mass="92915" checksum="43E34FF7940F50D8" modified="2018-07-18" version="1">MSKTPAPSHAESSQVQVLPVTPEDAPVVSAIVEDAFAEDVVSQLIWGQCDPATSRAASVAKLRQSLGTPYRTFRKAIGGDGDEVIAASFSSQVDASRTQKVEDPADPTPGTNLALRDEWFGMLGGLLEEYKKTEPRFYHLTILVVSPASQRSGAGTALLKAFLEDADRDDLPCYLEASDKGEWLYRRHGFVQCRERAHCGPDGVMNVLPMRRPAKSHRSASGVSVTRAFNHDALPLAELHRRSFAEEPWMKYIWGQVDDDAHCRRMAKYLASDLANIRRADAPGFRTPVGMSHAYVVDFEQERDRPAPAFAAGDDHEPGTDVELLKEFMALLAEVRSQFRQRDSRFMHVRILAVAPDAQRRGIGKALLEPILAEADRQGLPTYLEASEVGAKLYRKLGFVACGELASCASNPAVSVLPMRRPAHGVSVTRATEEDALPLAQLHRRAFAEEPWMQYIWGQVPDEAYVRRMAKHFAVDHAGIRKTELPGFGAPAGMSHYVTVDVAKDFERAVSASTSGAKEEDDFEAGTNVELMKEVDAVLTQVRAKFRERDSRFIHVRTFAVDPDAQRRGVGKVLLQDILADADRQDLPVYLESSEVGTKLYRKHGFVACGPLAAAASNPAVSGLPMRRPAKSESKGGDAAISQATEDDMLALAEVHNLAFANDAFMPLIWGQVDPEEHARRLGEWFKTEKLKIRKAVAPGFAKPVGMTLAYEIEVEKERGKEAPPLPPDDEHQPGTDVELFKEFMGMLARVRSKYREQDDRFIHLEILAIDPAAQRLGYGKALLEAVLAEADRDHLPVFLEASAVGTGLYRKHGFVECAERASCGPDGAISVLPMRRPAAKEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B023</accession>
    <name>A0A2S5B023_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="2">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B023"/>
    <dbReference type="STRING" id="741276.A0A2S5B023"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF20">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="8">
        <location>
            <begin position="59"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="425" mass="46257" checksum="6DFDB129AAA07897" modified="2018-07-18" version="1">MRPDGTQTPQANARTALNDLDDRRIRNIRPLIPPQILMEDYPLGLRAAATVLEGRKAGEEIVKGEDDRLLVVVGPCSIHDVRAAIEYAKLLKEYADQCSEDLLIVMRVYFEKPRTTVGWKGLINDPQLNGTYQINKGLRLARGLLLEVANIGLPSACELLDTISPQYIADLVSWGAIGARTTESQVHRELASGMSMPIGFKNGTDGSLQIAIDAIGSASSSHAFLSVTKQGISAIVETEGNPACHVILRGANSGPNYEVEHVKKAAEGLKKAGVSTRVMIDWSDMSELIWVRMTYSSHGNSKKKHENQVLVAEDVARQLSSPETADNIMGVMIESNLVEGKQSIPASGPQTLTYGQSVTDACIDWNTTVKVLNKLREGVQARRKLQGEGKARRGIDNRALATPGERNGSVDGRKDFNDTSLFQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B073</accession>
    <name>A0A2S5B073_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B073"/>
    <dbReference type="OrthoDB" id="2527550at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="459" mass="47061" checksum="46F26E83711352F2" modified="2018-07-18" version="1">MSATRTSGAGYTYAGGSGAYTTHPAEPKRVRNKLRKEEPTASVLPPPSQWSRGPIIYGHATTYGGVGQTGYQAPTAAAAPYAPSIATTSYGAGTGTGYGTGATTAGTSYGTTITGAAKGRTFSMKGGTYGQGTAASGQLQQKIEEAKEKNRQRRERHQVKRRPDEVLNRNLVVDDAGVPHDTDYVQHRAPAPLPVSRRPPTISETPNADDSASSSSASDSDASDFESTPYTYQSTHRTTTSSSHPASAAVRSGRYPSAMSAVPSYLSNGAPRHSLDSGPSGSSQRRPTSPSLHDGSSGHYSAYDRIGPGYGSRVTSSRLRSVTSPHATTASYQPPAPAFNPRDPIGSSVATGGGTSTASGGGGGGGAYGTATGGASSLVGSTARLSLNDSAGAANESGYNKAVKAGHVSSTRPPKLDGTALDAGMHGLTRSWDGFKLDMRFGAHKVGKKVSRKLNSAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0C1</accession>
    <name>A0A2S5B0C1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Adenylate kinase</fullName>
            <ecNumber evidence="7">2.7.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0C1"/>
    <dbReference type="STRING" id="741276.A0A2S5B0C1"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="6">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="268" mass="29537" checksum="38ADB3E5FE8968EF" modified="2018-07-18" version="1">MLSIARGAACVPRLARSPTPVPGPTRLARRQYLATAASVAVEGTRGSRKLRMILLGAPGAGKGTLSDWLLQRYDIDTIVVGQLLRNEIVKGSELGLQAERTMRAGGLLADEVVLQVVEPALKAMKDKDWILDGFPRKASQAVLLDKMLAETGDSLNFVGSLKVPDEVIIERIADRYIHLSSGRTYNLRFNPPKVAGKDDVTGEPLSQRPDDDPLVVRKRLEGFHEENDPLLAHYGREVHAFEGRTSKEIWPHLVDALAREFPDLPPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0F5</accession>
    <name>A0A2S5B0F5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Exoribonuclease H</fullName>
            <ecNumber evidence="4">3.1.13.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.2" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0F5"/>
    <dbReference type="STRING" id="741276.A0A2S5B0F5"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004533">
        <property type="term" value="F:exoribonuclease H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRO8NT" evidence="2">
        <location>
            <begin position="63"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PROCN" evidence="3">
        <location>
            <begin position="409"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="464" mass="54092" checksum="68FE0FA03489C473" modified="2018-07-18" version="1" fragment="single">MAASGPPPGFFPPEVGEAPPLPRYQEPPALSEEALAAKARKWQSLQAKRYKDVRKRGIVDTGKQPLPPQHLRKIVRDHGDMSNRKFRQDKRVHLGALKYVPHAVLKLLENMPMPWEQVREVPVIYHITGAITFVNEVPKVIPPVYHAQWATMWLAMRREKRDRRHFKRMRFPPFDDEEPPLDYGDNVLDTEPLEAIQLDLDEEEDAPVADWLYDSRPLLDTPHVNGSSYRLWNLDLPQMANLYRFGRTLLSDFNDRNYFYLFEPKAFFTAKALNVAIPGGPRFEPLFRESDNFDDDWNEFNDINKVIIRQQIRTEYKIAFPHLYNSRPRAVHISTYHEPHNLYIRTEDPDLPAFYFDPIIHPISSRGTAPKNEMIPHEATVFGDSDEDDEFELPEECEAFLADDELETERTADAIALWWAPYPYNQRSGRTVRAQDIPLVKNWYLEHCPPGQAVKVRVSYQKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0I6</accession>
    <name>A0A2S5B0I6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000127">
        <property type="protein sequence ID" value="POY70302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0I6"/>
    <dbReference type="STRING" id="741276.A0A2S5B0I6"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="244" mass="26697" checksum="DC4CC9FD4CE6C154" modified="2018-07-18" version="1">MAPIDFRRIDVDQYDEDRLDPVSLYHPDPRAPSQVLADAQQTDKQVRGLVQRGDLEGALREALTEGRWPYGEDAVPEIRQAKTTALATVLSILNSTRSTDIPNLVQQLSPDQHLLLMKYLYKAMENLGADTSGNVVLGWHEKVRFPLAWLVVGGLKLGGRTRGFFPPEAAGGSKDCASRRAGTARSGRLLTVASLLTKPRALSVPSAYDVLSCAAEPAPFHLLQLTEVAGIGCIVRVMSDRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0Z6</accession>
    <name>A0A2S5B0Z6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0Z6"/>
    <dbReference type="STRING" id="741276.A0A2S5B0Z6"/>
    <dbReference type="OrthoDB" id="2538032at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="607" mass="59967" checksum="BC79FE6AB136905D" modified="2018-07-18" version="1">MATSSSTLTGNSPETTTLQVPGALPASPESPASPDTPLSAAGALLGRSDSSGRLRRNMSAASSTSSPARQHRARSRSPAPATTHSLSALHSALPLPALATTTGGTSPASSPAAVTSPASLASGSATSMLSSPGRAGPAAALSRPAPVVPPSPSIPATPAYSRPTSPHPPASRSKDEPASPVRARGESSDGAALSQSASQVDLNHIFERDVEFPTTHHITPSEAVDVAVPPVLTEAAVALSAADDDPIASRDLAALVLDAEQDAQANSGWSSPVLPAGHSLHHWHSPQQQHQQQVSSPSAGPHQLSQAAYANASRSPVRGMRSFSPDSGSQSGERAASPGSSYFSAGTPPTSNGGGSPPATSMSASVQSAAAAAFAPFSQRLAEALESEASKLPPGLTGTSAVPAAAGSQAPSSPPEASGRSDASSASRSHSRNVLSPSFLRPFPTGSSTLSGGSEDPFVASPLASPGPEASATLAPPPLSSSSSATPTPASAAISSAAGTSGLAAPHPRKLSFATYADLVNEERLAELTGERLSADAAGTTASGAQTPGAGPAGATGLSGLSRSRSGTHSSLMVEQLETRLHAAAGLDIRGTSNSARSDAPEAAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1D1</accession>
    <name>A0A2S5B1D1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1D1"/>
    <dbReference type="OrthoDB" id="10690766at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="945" mass="102312" checksum="D7D1291D009460D1" modified="2018-07-18" version="1" fragment="single">MAVRLPQDVAGNGALLTLNENGHSCIDEQDAQALAVDDGTPAIASGPSSDTSRELETTSDDLGPAAFTTGAVFADEGDGLEVPPFLSVPDPAARLGHHKSTLDHLVEQEKARRAARHAREADLLSADLSPADLFLALIRGRQQERTYHAPLFDRSHPAVDLVLNSPDILHLLLGFLRDPFDPANLSSRALSNCDVDFLAAEKDVFATQSDIVNANALETVERPDGQSAPDASGTSSSALREQAGSSADYYLRAIDFPTQRLGRSFLGLYARNYPADIVVVELIEAEIARVHRSDDDPLALLYFGTTTMSTPIGRALQDAANGQHTTITNFLDLLKKVRSAGPTSYGDFTDVKSREFAVPALSLPADSVLDLNSILLEGLEMLGIASVSAVALNSARGGRLFRLDPAPLQEMRELVAKHGADWPSLQVLAPVDEEVDDSRRRAIEGLMTRQLEFWREHPDEAGKTLDPGTKGGANALRAILADATAGKTRLDGRGFGTFEVIVSKDVPGCCLDGFESMADLDIPVARGPFLRAQVDRAVQGFDLSQPFSLRVTAALFDFWAFNLKHKRVDIAVCFAIQHLHLQRPLLLTTRSGKIANLLRTRIFEQALAATQEADAFVNGRLDLSLDLLVVICTITELKWRETKPGSSIRIMGCTAIVQYSHLPNDLALHVATMDEGFHKYDPSVSDLVVDLVQLTAAKAAFAREALGRLLAFEYGATGVPAAAAPRREFLREARRRCEARSVATGLEARLLRARDELATAFGALNAARQLSAGDRRLADDEDRERKRRSESAHLGVANRAAQLEFVGPPLPAPVMSVLELHHSAPDDGFLLPKSLSLAVHPVLSDPLDPATLRPRLVQLVDLLAEHTEATLDGLESPVSALPTTGAPVASREWVGWFCRAPEGVEVARSASKAGWAGGRDWDAEARALQSEQQRAREEQKRASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1F8</accession>
    <name>A0A2S5B1F8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1F8"/>
    <dbReference type="STRING" id="741276.A0A2S5B1F8"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="1">
        <location>
            <begin position="258"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="539" mass="59143" checksum="9A91A95D6D8E85E5" modified="2018-07-18" version="1">MLLRPQPILSQTLDEVLSTLLPSTGSSNAALDGNCLPIWTTLPADILTPVVAYLRLTDGARGTESFLFESAVKGETAGRWSFVGANPKEIYRTGPNEEGGAVDPLTPLKAKLEEYKAIKVPGAPPLTGGAIGYVGYDCIRYFEPKTARDDLEDPLGIPESVFMLHDTLVAFDHLFQRVYVVSHVYLPSATSITKEGITESYRKAEEQIKAVADKLQETSPLPQVVQPRIDLSANPVPQGETAEERYVRLDKMSNVGRKGYEGFVTSLKESIVQGEIIQAVPSQRLRRETKLHPFNVYRHLRQLNPSPYMFYIECGNGTQLVGASPECLCKVDEGGKVTNHAIAGTVRRGKTPAEDAELAAQLAASVKDRAEHVMLVDLARNDINRVCKPETVVVDSLMQVEKFSHVMHLTSQVSGMLRDDQDRFTAFRSIFPAGTVSGAPKIRAIELVSALEREKRGVYAGAVGHFDFAPDSMDTCIAIRTMVFKDGVASLQAGGGIVFDSDEFDEYVETVNKLGANVRCLEQAEAYYAALQEEEDQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1R3</accession>
    <name>A0A2S5B1R3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1R3"/>
    <dbReference type="OrthoDB" id="2122015at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007008">
        <property type="term" value="P:outer mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035195">
        <property type="entry name" value="Emr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17237">
        <property type="entry name" value="Emr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="56" mass="6516" checksum="6E52A3CB4FB454CD" modified="2018-07-18" version="1">MALPNLRNIFASFRSPLEEREYSRRAFYTFLEFIGVTCLMHYVAVKAWSTPARIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2F1</accession>
    <name>A0A2S5B2F1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000093">
        <property type="protein sequence ID" value="POY70959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2F1"/>
    <dbReference type="STRING" id="741276.A0A2S5B2F1"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="32"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="90"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="545"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="673" mass="74414" checksum="1D5102CD00AEA36B" modified="2018-07-18" version="1">MAEHDYRSAPTHPISKRNNGSSHKPHANEESYAAMYRESIDEPHKFWDRMAKEHLYWHRPYSTVQAGSFEAGDVQWFPEGGLNVSYNCVDRWAYKHPNKTAIIWEADEPGQHVELTYEQLFQEVCRTANILKSYGVKKGDTVAIYLPMVPEAAIAFLACARLGAVHSVVFAGFSADSLRDRVVDAKSRVVITTDEGKRGGKTIATKSIVDAALADCPLVEHVLVLKRTGGNVKWTEGRDHWWHEEKESVQPYCPVEIVSSEDPLFILYTSGSTGKVKHPLQLPKGVVHSTAGYLLGAFMTLKYVFDVHPDDRYACMADVGWITGHTYIVYGPLANGVTTTVFESTPVYPTPSRFWEVVAKHKLTQFYTAPTAIRLLRRLGAEHTQGHDLSTLRTIGSVGEPINPEAWEWYNEHVGKGECAVVDTYWQTETGSIIITPLPGATKTKPGSATLPFFGIDPVLLDATTGEVIEGNEVEGVLCVRKPWPSIARTVYGDHKRFLDTYMTPYPGYYFTGDGAGRDHDGYIWIRGRVDDVINVSGHRLSTAEIESALIQHNGVAETAVVGIADELTGQAVIAYVTLKPDFKFDDADEAPLLKELVLQVRKTIGPFAAPKRIVLVSDLPKTRSGKIMRRILRKISAGEGDQLGDLSTLADPSVVDQIKEKYAAAPAPPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2G1</accession>
    <name>A0A2S5B2G1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000091">
        <property type="protein sequence ID" value="POY70973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2G1"/>
    <dbReference type="OrthoDB" id="10684595at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015592064" description="Pre-rRNA-processing protein RIX1" evidence="2">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="47025" checksum="F473C51D45B90AE1" modified="2018-07-18" version="1">MYVTAVSWEAAVQLRLALALVLLEHQPANVSLQGWLDSLRTLVKQRTAPSDFDATSPTTKTTTTTKPTSESSREPRTTLDKVDARYTADEWALQGGPEGRAGGTGLQAESRQEDAATAAAEEDAVPQSTQLRLAASNLGPPVIAALEALLIASRSPFQPSQASDPSGSNANSTAHRFLAALEASLSPTELAQEEPAEFVVKFDALGVVGKWFVDLIAKWRAEHPAHEADSNGGYGTRSKGKPPNQSAATPAEEEVAQAADAALERLAILLTSLLPLAVMHPIALGNLAAIMIQLSSSTTRLARSRILPALLQHLLAPLQSLVVLPSSLSNERILNDAYATDSHAVERISAILSLAHLVLDATPPDGHARGGEGEGGSEELGSAQSELVRFLGTHGVDAQLAEVQLPFSAAATTLGGGAGATSVESAVVGLVERIWEQVDAPDDANEARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2I8</accession>
    <name>A0A2S5B2I8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_6079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2I8"/>
    <dbReference type="STRING" id="741276.A0A2S5B2I8"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF9">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY70901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="701" mass="75822" checksum="AF576C32124DCAEF" modified="2018-07-18" version="1">MSAFAAMMGGAECSTSSNPLNQFVKAGHQDHSLHGQHAGPAAGPIHGHAQSMRSHTPQDQLAADDAAVRFFEQQHGAATPLGMDQLRSEIDAMARVALKNDRVNEREWASQYRPAGSNLSPAEIARMQDQFRMPAGQEGRPSDFAQEFHSLQHQHQQHHAQSVGPAAGPASAMYAQSRPGFAPSYGAFGTMGGGGGGASYMPMHSNYATPPMAQQSTADLKGKGRFVELDDADWEAQFAQVASSSSAPQQSAESQQVSASAAQEQEESTANLLDHGEIDVDASESDAQLLKDLESTWAAMRNQLDASNGTSDAELAQWEAQFGSQFNDIHGSPLLDADEADDLFDNIPASARSRRSQWNKDNVDAFLQDQTPFPYNEENDYLEHADPYAEGMRLLQEGAPLSEAALAFEAACRKDETRAEAWKAAGETWAADEREVKGIRALEKAVACGGPAGISAWLSLAVAYVNEGQELRALATLEKWLSIAYPSTSLPALDAMQIKSPWDASNRVIDLFLAAAQAGPAHRAPGQSSDLGIVDPDVQVGLGILFYSNSEYEKAKDCFEAALSIRPNDFALWNRLGATLANSGHPEDAIQAYRKALDLRPTFTRAIYNLGVSCLNIGCYHEAAEHLLAALQGQMTREEMAQNRKGKGRGDADLGRAELGDGSDNLWHTLRRAFLCMDRHDLADKAMPGASLDEFRGEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2X2</accession>
    <name>A0A2S5B2X2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2X2"/>
    <dbReference type="STRING" id="741276.A0A2S5B2X2"/>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1270" mass="135383" checksum="9FC171E97C24BBF9" modified="2018-07-18" version="1">MPRAHVPAGSAAASQDDSLEVHPATQHAEQIRVDEREASPLTSLDSDAGEEEASLSESEEEPAADSQGFWEAEAILDENKTSFLIAWKGTDPRGKAWSPTWEPKSNANDELVRYWRQQRRDARKAGKAAKKERKVEAKSVRKAVKAVQSEAEAEGARNKSKEKSSPIRSRKRSVEIAVEIPPPRPSAKRKMVIPSSPEGTASPAARPPKPAEEPAPPARDGSPVRKKKRVTFDLALSSDGEEHEQPIVRAEPAKAVNVRKVEIPIQVKAPLRADEPEAEQLVQSSGSSSTSSGATVIPDSQAIPAEPAVSKATGHARPAEPEHLRYDLQGPAHSPATSQSDLESVHAHDDDVPVFDPLRRDDDEDRDSSAEPEQQRRMRPVPVPAAAMFGIFNRPALQSSQLDPIEDPDSSPQRPGVGRQLSEQRNSPRAAPVKGRLELVVQDDDSPASSFEAEVQSTAAASYVTLPLSQPDEADLARSILFARSISSRSGSRASASPSQAKRPRTFSAPIQHDEFSGEGVVAFAATRATPSPSPSPRLDDRLDLAAVEADFEDLGEFAERFFDEIFDFTGGAGASQARSGAGTAGEARDAGEQQPASNGGHSGSQSSASQGTAASQGYGYSNAGPAYAGDGVGPSAFAASRSAGDFSQQNFPGGPYSQPPYWPGAAATAAPSAKRPFEDEIANDGKKPRVEMPGAATYASTPFDAILNQPSAPPMGAQSSASVYTQPASFGVPYGSNPSQAQTRVPSVGLSQAAPVALTSPSLARVQSAEPFVIPKPGKLAAGEVSPSLARQLSGFRSPSPLPPPAAPAPPHGPPYVGQTVSRIGSPAPAGAQVENLVSLVRASPSISATDGTKEEIERFLRDPQGYASTPSAPLLVTEFWAFELRRHVVDGVEKVDFIIIRSREGTFQLKRASADKVPIEFARSLSQVTSRARGMTPLVEAAPNLATFSPSAAATSATVQPAVSQMTREQLELEVEQLRKQSKSTEVELSTLRPLTAEVAQLRNEVQTLTKQNKSLVSSRESAQSDLSYMQAQYQAASQAAVERASECRIAETETARLKGLLEAGIQQKEAVYKSEIKAVRSMYARMQKQMALYKAESRRMQEAQVREKAAKWDDHVATLKLESAKAARREAGRPAEDSDDDDAGDVPAATYSQPEPSTIVSTHDPTASSPSQLPSHVPAASLGLGDLEPDVLQPNQPLLAVNSAAVSHATLNLDDLLVDDAGAALGPQQYRCEWRVGPSDTQAETCGEAKDSKTQLREHVLRDHVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Y4</accession>
    <name>A0A2S5B2Y4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="741276.A0A2S5B2Y4"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DECR2-like"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
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        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GDHRDH"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="281" mass="29936" checksum="DFB487B01C764A1D" modified="2018-07-18" version="1">MTDSVFKNDIFKGKVAFVTGGGSGICYGITKMLGEHGCRTVILGRRKANIEKAAAELTKSTGQKCLGIPADVRQLETLEAAVKQTVAEFGRIDFVVAGAAGNFLAPIDGLSSNAFRTVLEIDTIGTYNTFKATIPELLKTKGAFQAISATLHYKGHPLQAHVSAAKAGVDALVRVIAVEYGPRGIRANCIAPGPIAGTEGMDRLMPKEYLDAHLKQIPLQRYGRIDEIASASTYLFSPAATYVTGTTLVVDGADYHMSGSHRAEMDPATYQRKDGKGVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3M0</accession>
    <name>A0A2S5B3M0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
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    </feature>
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            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
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    </feature>
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            <begin position="362"/>
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        </location>
    </feature>
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        <location>
            <begin position="416"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="325"/>
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    </feature>
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        <location>
            <begin position="369"/>
            <end position="385"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="639" mass="66168" checksum="5FB42695C70DC7D1" modified="2018-07-18" version="1">MALLKRTRSLADFFRPPVARLDDDHDRGAAAPRRNASTRLPRTARLDPDRPDLDAYARQASTRSHSSSPTQTRRQPPPPMIRTTTAGEADGVTRSGTVEDILTAYYAESPTKSRHAPISSSSAGQFLAGSPTRTREKPMPPQRMDSTNSASEDGDDSGSGILPVLSHHDNELTKARKDAEANKLQAQALKSSQRSSKSGRPSNSRSKSSGDLDLIDRLDISGLYGGGGFIRHEGPYAAAMAKGQGANAPINAFDPSAFSLAAPTSNGSNRKPSRRTGAGSSRPHAQSVSGLDDPASRSLLSPYAAAAIAGTSASSSSSVAGGSSSEVSLGFPARHADNKGQQLQEIYGVRDAEAWEDYGRARYDDSSLGPGDASGATSGAASRESILPGGPVSKEDRMQRAQSIWDIEATLKAGKPVGAASSAPPPVPILPQDLSAYAAGGDLSPSISNSPLTASGGGSKPKRSKSLAARFRAGRKNPNNPMLDADPSSSGEDGRIAGTASGPGSYDAHEAGSASVPVSPVDERRGLREWPLGASVPASIGATHAQSHANGLVASVPASRGRPSEPVANGRANGDVKQLEVRTQAIKFDESLSSPTLERASAAAAMNRSLTDDGSASPTSGSGKKSNGLKRLFSTKRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B403</accession>
    <name>A0A2S5B403_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B403"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1257"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="768"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="899"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1116"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
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        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="782"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1391" mass="147297" checksum="E1CE8961C5343B4B" modified="2018-07-18" version="1">MAAVAPAPPATPPRSASGSLRTTPAFSPRSPAAASDASASSRPSSAIIYGVQGAEGGVEAITARRRNSGSFKHMATGGLVSKSPFTQHKSGSTPASPTKTTSGTAIPVANGLYRRTSGSSRRASTEIDGAVKENSWPSDLSEVANGPAPPAGSYKSPNSKTRAFFSSSPFKPVPSSGSQTAGTTTTLSTRSTPSSSPFKPTRPVSTHVREDSSNGAEEPRRQTSSFAALRKNNLVSSSPFVADKQQASAPSPDLPQVPYEIGALTHESAPMDFHQQEFDDAPASTTAQHLANARARAAQVEAHGWNGPSAQGGNVSPTRLYSSSADSVKSALTSARRGMRGPRPLGGTASSSPDDGDETEREDLPRVIRRQPSSKSVAWAETEEVFEFEVESERRHSLMSEISTDDGRYYNSSSDEEDATHHTDSEHSGHEEEHDGTGFSWSLQQINAARPVRGAQEEEDDDDHNSDAEASVISTASSAMDEIVGQIDEYLHEESLDDTHIFSPSQIPSSFEDQPDIPSHHDTSGYSSPQIPQGPQSAFSVSSVSAADDTASEVLSTSSYGGESEEEARVTVAQKAVFSVSSAPPIALPPLPPRTELPSRPADELPAVTALPSVSALAHSDSQFSLPDIPGTSPFLGFEDDGKADSVVTLSADTRPLILPPTRPLQPQSPAGSLTQARAVAQQQQGSLRFVPSPIMASVHRMAERGLASPINLDASPALSRKASLVGSDVTTSSISWYGSTASGSLRGGTVRLGRDRLEERMKAHQALFGPGPDSPVASFGAFPTPSSPAGSSSTEASRSTAPTSVGDHAEHASKAIPNRAIEARPAPKARSATLSSTMLPTIAASPQRATLDVSIGSPLTSRVAEEMQSPLERLQRGMQDREGEHEWRSGDSLLGHANANADVSGDDLAPLTNAFDRVRGPARRRSRSTGDADVAETSSILTLDVQPTMPELGFEASAADEGFGSSVLQSLDDIYNSRNRSYRVRESKQVVVVSDMNGSRAGDVDPGKAWRRKRPSDVHAINRSLSTMSIAAPSARKAKELSGQLFLLLREVNFEGMPLPRQPVKLTAVLDNGRQRVDVAVRDLSAKVALKKEFELVCSADLMFAIHFTVPRPSAASTPVLPQSPPAVSTPPSSPTKAQRALRLFSSPKKKATPTKSASPAPPPTPDPFWDYVSTDGELATSRVVFATEASNCRLKKSRLLVPFGAKDSSSPRSCSGSLVIDMLFVPAVSGVPKAQLPKSMDEVLAGLEVLDTATTVAFESPLTQLGGDTTVWRRRIVKLRGGMLVPYSEVTKRSHVEIDLSLVSHVADLNAASPAGKASFDDDEEDLACMDNSFRLLFKDGNRIDFYADSPGDKARWLEVLGKTIAAEGGVRVAPAWSIAVRKLPTPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B468</accession>
    <name>A0A2S5B468_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_5814</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B468"/>
    <dbReference type="STRING" id="741276.A0A2S5B468"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="53"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="256"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY71501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="484" mass="53700" checksum="56AFA266C11EB3B1" modified="2018-07-18" version="1">MATVLRSLQDRLADPSIPWKTVLLASIGAKEVFEAYIGSRQRPYLSPILHPTLPSALKPYLTASDAHDTYRKSQAYARHKLDYDSVLTIVDLCETIVFLSAVAAPVWTALGLPGGQGPHWTLLRGFWDLAGQLPFAGGGHSEIRQSSALVVLLTVIGTVMSIPKEYYRNFVLEEKHGFNKMTRGLLVSLALEVPLIAGLIKIIHWAGQDAILRMVAWLIAFIFCIQIAMIFVYPYVIMPLFNKFTPLPTDSPVYPRVKDLAEKLSFPLGKVWVIDGSIRSSHSNAFFFGLPGLQKHIVLYDTLLEKSKPEEVEAILAHELGHWKGMHVVYLLAVALTQVAVSFATYALFLENGSLLSAFGFPPTPSHPVHFTKEKLGRAHASTGPTIVALLLAMMLFSPLSSFLQFMTNSITRHLEYDADAFATKLGPSYATNLKTALVTIHEKNLAVYGVDHVYSAYNHNHPTLVERLEALDAQLELDRKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B475</accession>
    <name>A0A2S5B475_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000079">
        <property type="protein sequence ID" value="POY71580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B475"/>
    <dbReference type="OrthoDB" id="2527568at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="495" mass="54844" checksum="CD224807685627C2" modified="2018-07-18" version="1">MPLIRFPVAPPGVNPYDYFARYLDAVFNPLPTQGFEARLIVLWMLTGYRRRAKSLWLFKFVRRPAGRYLVGNSHLIFSLASFLVCTVLLGYLYNFYCVALLKTAQSNAFFWRTLIWLPLGGHLWFSSWSSLQASRLATQSACMTRYLPPVVANALYLGGLLVLFVCGLTLDIIISIKWNRVWRLQRRLAIRSLLFGALRPNDSVAEARTFTAGALGVINTELDRTVKLMRGIGSVYSVASAIIPAANIGGLVLLVILRRQIRFNTDRFQAAEEIAEPPQQQPSSPKHTPEAGTPVKSYPGHAFFPLPRLRADSKASQQTPSPIQHVRIVQDVQQYSEQLDGDSSPSQSSDDQQVEPTSQPEPVARGVGARLDVAAERQLVALRKVHADVAVFSVAIALLACLSLGTGLWLAISPTSVYGRFERLEAVYFALVWGYLIGIDIALTLLLFNTLSHFPSKTGTGATEPLPPVLFLPAVESEGADISRTPFDRIEMRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B499</accession>
    <name>A0A2S5B499_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000076">
        <property type="protein sequence ID" value="POY71597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B499"/>
    <dbReference type="STRING" id="741276.A0A2S5B499"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015754078" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="296" mass="32042" checksum="AB802B4CA4588247" modified="2018-07-18" version="1">MSRVSFLSAASLWLASDQSRALTGYSVQPLFGRLCEWPSFEPVNDTVRGGKSTSSWRVDPRTNIGSFTGHLDITALGGAGFASQSATFGEDAPLSLGARHETSGLLITFIVPSSDDSRTSTEPARPHRLVVALKEEKPVRRPDGRRESVTVYQFTVDFAHYAGSFSCGKEGDLDKGERAGEAKEEEQVTVLAKWDEFKPTYRGRPKEDATPLDPSLSFMCRSNFGDQAGPFHFDIVSLAVAGASRDAQSGSRFRERVASWFRAVVEVVKTGWARVRGLVAGACGGGGLFSGPVRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4B0</accession>
    <name>A0A2S5B4B0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4B0"/>
    <dbReference type="STRING" id="741276.A0A2S5B4B0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF356">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="281" mass="31967" checksum="D292A9478E85ECC1" modified="2018-07-18" version="1">MAHLHGSHWYCEPCDQIFKARASRRSHWANSKRHEDDYCGLCDKLLDACESLHEHEKDCHIGCRGCTQFFLSLEACHQHGRQVHPWCEVHKRAFQSQNNYEQHMRSAEHVGLHFPCPGANCGRKFRNRGDLTAHWEQGTCPSDINRTTIDYFIRANDKNRMITSGPPRQLLTDAASPIVYLATERSYSWTRQAYVCALCRSEHRTLHSLNQHLASPRHTHAGVGDGLKPYKCPAATCGRHFLTLSAVIRHAEQGVCPVLQSPPMSRALDDAFGGMRQLTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4D2</accession>
    <name>A0A2S5B4D2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5334</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4D2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4D2"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="94" mass="10905" checksum="151E25A52AEDD3A5" modified="2018-07-18" version="1">MLIFSVLKTLQDQELTVELKNDLAITGQLKSVDQFLNIKLDNIRVQDEERYPHMMAVRNCFIRGSTVRYVQLPRAAVDTQLLEDATRREAGKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4G6</accession>
    <name>A0A2S5B4G6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4G6"/>
    <dbReference type="STRING" id="741276.A0A2S5B4G6"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="910" mass="100825" checksum="6EC6ACC32245B97C" modified="2018-07-18" version="1">MADIFGLRGDRYAFLRLAPPPSYVAGAGRGAQGFTTRSDIGPAREQVQDGEDAAPKEEEYNPDQFQDPENETGLFAGTVYEADDEEADRIYEAVDAKIDERRRARREAREKEEAAQLLAERPTIQSQFADLKRGLADMSEDEWYNLPEVSNLIGNRVKKPRLEGRSYVVPDSILVGNRDANALESSLAEEEMKGGMQTPADAMTDFAEIGQAREKMLSIKLEQAGTDSALGSTNIDPKGYLTGLDSQLLKTSTEIGDIKRARALLQSLTKTNPKHAPGWVAAAWLENVAGKQVAARKLIAEGCDQCPKSEDVWLCASELNTNENAKVILANAIQELPQSVRIWMRAVELETDVKAKKRVLRKALEYIPASVKLWKETVKLEENPEDARVLLARAVEVIPHSQELWLALARLETPDRARQVLNSARKTIPTSHEIWIAAGRLQEQEGNIAQVDAIIANGVAALKKNGAELSRDQWLAEAERAEQQGSTVTAQAIVKATIHLDLDEEDRQVVWMDDAETMANKGMVATARAIYAYALNVYPQKQSLWRKAADLEKQHGDRESLLALLNRAVESVPQAEVLWLMAAKESWNGGDVDGARQILSRAFESNPDSEGIWLAAVKLEAENGQIEAAKQLMQRAREVSGTERIWVKSAVFERTHSGNDAALDMVKQGLKVFPASAKLHMMHAQILQAQTPPSIPAAREALAAGLRKCPTAVPLWIMASRLEENAGVRIKARALLEKGRTLNPKSDELWLESVKVEQRDGTGAHKPMLARALQALPASGLLHSYSVWLEPRPTRKTRSVDALKKTNNSPSVIVTVARLFWAERKVEKARDWFGRAVAADPDYGDAWAWWWKFEKQHGTDEYRAALLEKCIAADPRHGQMWPTIVKDPENVGKDVPALLDLASEALEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4P7</accession>
    <name>A0A2S5B4P7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4P7"/>
    <dbReference type="STRING" id="741276.A0A2S5B4P7"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="259" mass="27739" checksum="F42D6D2F90F7EC07" modified="2018-07-18" version="1">MSAENAADATASTSSPAPAVPQVGGDSSAPAAAAASTQSSAPKPPKNARGRPTDDPDTRWSKTLSYILRHGAAKEGLKLRSDGFVRVEDLMKRPKLKGCDLDTLERIVRDNAKQRFTLQAEPTGQDGADELWIRANQGHSVKVEALELKPVEKAEQVPIMVHGTYYRLWPAIETEGLKVMTRNHIHCAIGLASDAGVISGMRANCDLFIYLDVPRLLADGVPVFTSTNNVVLTAGVDGVVPPKYFSKVVKKDGEVLIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Q9</accession>
    <name>A0A2S5B4Q9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Q9"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Q9"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="10">
        <location>
            <begin position="268"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="467" mass="47088" checksum="0ED3230F075C6FFD" modified="2018-07-18" version="1">MFAQSTGQSQYRAGGQSGLFSTPQQSSPFGQPQQQQQQPYGSASTAQAGSTSTFGSQSTFAGPQFGGGNHGAVFGSTGQFGGAGSTSASGSTAAGGAFGSPYGGTGAMQSSSTGTPGQKRAYLPGYLSSGAAAQHADSSPQVNSEDRSWDSPARKASMSGSPATRFGGGSLFGPTSGTPSKSPRMSSYTAPPRKSAYRQEIEEDAPPVASLHEFDGAESCVNQSEDCIRDPSDRIASHSSRQTASHDPTASPFAASGLALPSAHGSTGSDGYAVHVFGFPASATDLVLDFFAQFGEIVSKSPSTEGGNWVTIVYAQAWSAARAARRNGEVLGGVLMIGVKAVDEDGLKRALAGAEGGHELAPSASSSAPTPRPSSSNNNNHNNGGTSTPSGVGRPVNVLGPQAAFKAAPTPTRKGFLGLGGAAAPSTPGNADPHASLFAEKSKQAALAQQPQQKGVLGKVSDMVFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4X3</accession>
    <name>A0A2S5B4X3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4X3"/>
    <dbReference type="STRING" id="741276.A0A2S5B4X3"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="175"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="429"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="509" mass="55382" checksum="8EE916AE128400A5" modified="2018-07-18" version="1">MSLPQDLNMHDLPKQPYSSPRLLKWLYCTHRVGSSLALLPYWAIKYALGKRPRPSWSIRETLLIDFTRRVSAISDQAGVQHATRDPTEEPKRDSLKETRFEWAPGIAGDLCCGVLDDCEVHPLERVGTFIWERAEDVRVDYTRFNDKGTREDAGDDASILSYGQDGGDKGDLVGVYLHGGGYTHFSAHENAQTSAIPRRLMEYDYFAAIHAVEYRLLPASSFPAALQDGISVYAHLVRAGVPPEKVVFIGDSAGGNIALAMARWIRDEGKLPAPGGLLLLSPWCDPSRSFPHSTTSYVARPNPEDYLADAPAARRLLVTSLLGKKPHEFLTSPYISPASALGTHGCFNDLPPTFVHYGDAERLLDEIDALVSGMRRDGVELDVEKTPDAVHDVLMVRFWNEGVRGHIYERICGWLDRIVERSGTPTRSRAASSASAWQAPAGAPTASASTSSSPASPRESAGGAGFRRTTPSSDSLAKGKAGGSSDGQAARTQVIPADEAGIDSIEEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B513</accession>
    <name>A0A2S5B513_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B513"/>
    <dbReference type="OrthoDB" id="2535845at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="342" mass="35209" checksum="94B50729CC088426" modified="2018-07-18" version="1">MARSLFAVYRDDMAVAGPSNAFNPASATLTNKPSSRRQDDAQPLTATRRGLGTREKENDNPFGAPALGKAAFKKGDGPLKVAKSGEGSSRAPVRRGLGASAKVGLQIARPSTNGICTGSLRTRVLPDLPPLPVDSAATGPSVSIVGGDHDSASEVLPVVEITTGETHSAESSPRGSCDRSYASTTDSGYAQSPTPRARTRPAAPATSPVGDVDGAEIDISLVGEERPIDVADANRRARALTESPLAEVTQAFTGLGGFSVANMSPSPAAPPAFARSNLVHPAQYRPSLLRHPSSPTRKTASSSAAAGLRTARPPPTGTTKKIKPGQTVASAPKAAPKRTMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5G4</accession>
    <name>A0A2S5B5G4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_4958</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000062">
        <property type="protein sequence ID" value="POY72024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B5G4"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="16">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="305"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="587"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="728"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="788"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="883"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="974"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY72024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1304" mass="147804" checksum="57AB2BF46AAB260C" modified="2018-07-18" version="1">MSSLDKLAIRGIRSFDSQEYAVMQFYTPLTVIVGHNGSGKTTIIECLKYAATGDLPPGAKGGAFIHDPAISGAQTVMAQVKLRFNNVRKEKMLVERRLQVTKKKTASGLSMKTLEGVISYADNEQVDKKKRQTLSTKCANIDEEVPAQLGVSRAILQNVIFCHQEESNWPLSEPAALKKKFDDIFEASDYTKVLDEIKRIRKEQTVDIKVDKEKLSALKTDRDRAFKLRENLKKVSSQIAIKQANFDELEGRIAKLVADNKSFFNQASKYQDIISKVETLRDRRKMHEDNLNDLLTGLRELPDSEQELRTKIDNHEADVEKMRGEREGTKNKLADEQDALAVYERKRSAAQTSHGRLLALKQRHQDLLEARKTLIRELSEKHEIPGYDHDLSDHEMQAFEEKLEDTIHAQQKKLEKIKNDARSAEGKLQDRIQDLKSKRAADERAKENIAAQIRAAQARIASVSRQLDATSATVADISLIKSDLDEARDRKKKIEDQVKTSNFTQQLRDKAREGKELEEQRDALHAGLAGLNTQANTRAKLQLRRYEKKRKEEAMHSLIDKNAGSFRRLLNSDPRADSMEAEVSAVIETHSREVDFAERAAKDAARELQNVESSVDFSRKRVRDLTEKSQAAHDRIAAALKGMDVADQSFKEALSEAEKELDHLVTRHGRAETDSPRRGSEIAGARSIETFYDSVLLKANRSQVCLGCNRGVSHEELPALEQYVKRKKQQAPEALRGLEEQRDDWQQQLDTLKALAPTEAVYQRLVKEELPAAKDALTAEEEKLAPARDKAKEQADRLTEVKDASRDLQTLKRAASDVLRLFRECEDVDREVAKLESELSATGSTATTEEIQDKLSALADHIRLVKTSTDKIRQEQQSATSSLQSLSESIHAREMELAKKEQELKDKEALERSRKDARDEIGMLEGQTKDLDKRLNEAIAPIRAAESELSTLRADFTRDETAASRQLQAYNKSVEQLDLNKREIRSVISDAKKRFSALQTQIARIDQNQADSKAILRGFQDNLRVRIERRALKDIEDEIETLDEHGARNAYVKFETQYNEQRKKQTELQSEQARLGGEVQTLEADEKEKREELATEYKDIEEKYRRELITLKTAEMANQDLEKLQKALDGAIMRFHGLKMKEINDTIADLWTKTYQGTDIDKIMIKSDSEGKTTGAARSYNYRVVMFKDTNEMDMRGRCSAGQKVLASIIIRLALAESFSLNCGVMALDEPTTNLDHDNIQALAASLNELIKERRAQSNFQLIVITHDEGFLETLGGSGVLDKYWRVSRGDGGQVSTIERQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5K1</accession>
    <name>A0A2S5B5K1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5K1"/>
    <dbReference type="STRING" id="741276.A0A2S5B5K1"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045437">
        <property type="term" value="F:uridine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015910">
        <property type="entry name" value="I/U_nuclsd_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01247">
        <property type="entry name" value="IUNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="383" mass="41806" checksum="DC85DB3BD938D3A3" modified="2018-07-18" version="1">MTATNAKIPVWLDCDPGHDDAVAILMALHLPQIDLLGISAVHGNASLHNTVRNAARCLLAFGSTEQIERIQVYAGASEPLIRMSRVDNEIHGEDGLGGVEGLPDASDPAVLAKLEATRGQSAVLAIADAARALPKDKKLVLVATGSFTNAALFVSLFPDLVRDKVDKVVVMGGAEGRGNRSPTAEYNILTDPHAASILLNHEISVIMAPLNITHTAIFRSHDNETLLHAGQTPDADSLVNSTPATTSSSHPVKAHTPLRHTLHTLLNFFAATYKHVFDFDEGPPVHDALCIAYLARPEIFRSKRYRVDVELEGTYTQGTTVVDLYDYRKDELKDWLEDSESRKSWGKLGKNAELLEELDVVEFWSMFQQCVDSADKVSSLNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5R2</accession>
    <name>A0A2S5B5R2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000059">
        <property type="protein sequence ID" value="POY72096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5R2"/>
    <dbReference type="STRING" id="741276.A0A2S5B5R2"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="186" mass="21310" checksum="A69881F2BBBB9F88" modified="2018-07-18" version="1">MHLAPTPSADFGFPIPTNCGVTVQDNTTESDWATFWSKRRLGNMLDRIGDNELKRIGREVQQRVVPRLLGELDVKPWLLHGDLWSGNARYSRDRTSPIIFDPASYYGHSEADLGIMPMFGGFSTAFFERYHELVPKSEPVDEYKQRLQLYEAYHHLNHALMFGHSYKCGAMSLFTGLVRWADEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B635</accession>
    <name>A0A2S5B635_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B635"/>
    <dbReference type="STRING" id="741276.A0A2S5B635"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015560418" description="protein disulfide-isomerase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="330" mass="34136" checksum="B131A14DAC1654F2" modified="2018-07-18" version="1">MKLTTATLATALLTAFPAVLAGLEDAKHSTVLTSKNFDGVIASQSEGTLVAFFAPWCGHCKSLEPVWTKIAAQFEGDDRCKVAHLNADEPDAKPLATKYGVSGFPTIKFLEPPSKGGRVEAYGGQRTEEAFLHFLNEKCGTHKLAGGLLNDLAGRIPSLDSLASLYLTPTATRPSLLSSASALASSLSDSAADSPLAAYYVKTMNKLDSFGTDGAELARAWLDKERTRLGKLAGRKGQVSAQKIDEARMKQNILAAFASASASISSAASVASATASSAGSVVSKSASSAASVVSNSASSVSSVASETIKSVVDEASATARQVVDRVKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B674</accession>
    <name>A0A2S5B674_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B674"/>
    <dbReference type="STRING" id="741276.A0A2S5B674"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="68"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="444" mass="48690" checksum="E066B9AD0B1E413A" modified="2018-07-18" version="1">MSAYHSNGRRHPASLIPKSWHDPALLEFVRAPVSQDMIAYLAAKAVEVIQCAPPPAATLPSPPSTPTKTDFEQQRDDAAAAAIPSLESFITVLVQKSNVQVPTLMCTLVYLERLKSRLPKVAKGMHCTRHRVFLATLIVAAKYLNDSSPKNKHWTRYAALFSQAEVNLMERQLLFLLDYDLRMDESELIHHFAPFMRRASPVASSSRHAYPAAVPAAAPMPAQVEQKPVSPCTPSSAAGRRPSANEQHAYPTPPPSSSRRTSPYASQSTQLQQQQKRPAYVSPTDSDLSGGTLSDIESDLSDRDCDLRSNAPPVRLSSRSRQAYALPAAQQAKSASPHHARMVRKDSQPPSLPVTPTDEVSPSAYAYSSKLQSFPTPPPSATAPPLRSQRSGSFLRMAYEQGKGMLSRGSGAGHSQQQQQQAKQPLRQIDPARHHNSRTYEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6A1</accession>
    <name>A0A2S5B6A1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6A1"/>
    <dbReference type="OrthoDB" id="3353671at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015639547" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="118" mass="12457" checksum="6DEEDD8482793C5E" modified="2018-07-18" version="1">MRFSLVALFAVAVPAALASAIPSYADAQNAVSTARDQVEQLTFGTLDNPDDACPDLIVRCVRKDKGGELVGEIGKKSFCHPEGTLKCKQCHTKINTAECNAKYPIDCAAKCSAVGSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2019-12-11" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6C6</accession>
    <name>A0A2S5B6C6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="12" mass="1589" checksum="7619FEA6FD15AB5B" modified="2018-07-18" version="1">MSWMEYSRQKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6G3</accession>
    <name>A0A2S5B6G3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6G3"/>
    <dbReference type="STRING" id="741276.A0A2S5B6G3"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF89">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="787" mass="87624" checksum="CD330C2162AFB386" modified="2018-07-18" version="1">MSREYWSDQPASAFHRTPYDREGPHAFAGGPSPQSYTASAATALIQPPYLENEALAHHATLPYDGSAYYTQSRQPDFVDLQPDPEFFRDPTYGYGIRSWDAGYRDDVNSGASEGARYRLATDATRHSSLLAFPQHQATPRFPRTSVTSGSSQSDFYGTPRPSEAGKERRKASTGTRKCRPASCTPCRTKKMRCSRSKPCTTCVNRGDAEGCLWEGDAVPLYTAGEDDGMTRLQAHIKRLEAMLAAHPPAKERLSAPASASRRPAARADKADPPDQRTLPKAEDYYDMTAQDLGGALVSLITAGAVVPSRAGQESFLSNGQSSRGLLAECETLVASTSIIDQSEPPCTAALPDAATLNLKEMLALVPSEREMRIAYDFYRPRFASFYYSVDHDEIEARWPRMKAILDARDAALFAAEFEPHFFALVLATCVAGLSRMPESVAKQHRMHDNCAAEGVRWAKIAVLFLEVVSPPRHCETSPRATDLLFHLAQPMDSPTLDTVRAATVLGLFFVSSASGTPVPRGMRMFSLGASAALELGLNRDPLEGTLRECEEHRRTFWALFVLSIYATSATGKSPPIFDLRYVDCAFPQEYHNDELDLDERAAIARLRARRASGKFEETWLTSQTHHFKIAYLAKATYDEVFAARLCSYEAVLEQDNKFVEVEAAMPEAYQFRNFHDEPLSLTVQRAVIIHACLSAEVMRLHRPFLSLAANDERFEYSRARCVKYARRTLYLYNADWLMSFLPRALACICILLDLSSGRTEEREEDLARVQYAYAQLDAVRHTSGGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6H0</accession>
    <name>A0A2S5B6H0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6H0"/>
    <dbReference type="STRING" id="741276.A0A2S5B6H0"/>
    <dbReference type="OrthoDB" id="21643at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12226">
        <property type="entry name" value="RRM_NOL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034138">
        <property type="entry name" value="NOP8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="678"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="713" mass="76914" checksum="8B45F5B96F77E7EF" modified="2018-07-18" version="1">MAPPKPVLSTEPTTKRVHVGNLAPSVTAKDLVQRFSSFGTVQGGEAGVHGLGKTETGTSRSFAFFSLDTTDAKFARCMSMLNGSTWKAHKLRIGPAKPDWQSRMAAEREAAAKATDQQTTGRPKKRKRSKDPNVGFAANHFELVDTENMKRHRGWLLDPKPVPTPIFPIIIRPSHPVAPPPAAPTTAWSRAPVKAKPSKEARAAARLGVALEPRQPLRAKRMRIDPRRWGRQKIVFDVMAAGGKGAGAGTTSMAAIGTWECEEPEEGAPVDKESVTWVFKTRDGQVRRRETVRLTQRTAHTDRFTTLLERINQSATAPALAPERVAKAAVPAEASETAAAEQAPTTRARSLSPPPYVPIAPRNLIYNEEDEFQLVASALNEEERAAAHEQERAAYRKLALSALAELQNLDDVELNSEAGKATAEVATKPLPMVEGFAQDDEDDDDVFETLRLRGGAGGEAADSDSNSDSNSDSSSDSSDSDSSSDSDSDSDEAVDRAKSGEEAEAAAKPAAGLKETLTALFKPGSAAVSADAAANDAAGGFSLFSGMDLDLDVDAEIEEEGVAIPLAPQADTVPAVRPIPQMAPMRGSRFQQQQVSSGLGGGISKPFFAFPSGAFEDPERPGEINEEEVAKLGLPAVSIERAKEESKRRIEDATRDFWQHESQEAIDENHLKMRETLRGVARKRHREAVKRTRKTGGHGRRGQTSVPLDLLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6X9</accession>
    <name>A0A2S5B6X9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6X9"/>
    <dbReference type="STRING" id="741276.A0A2S5B6X9"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="66"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="137" mass="14463" checksum="859265E8D19502D2" modified="2018-07-18" version="1">MSMNIDKPLDDIIGEKRKSRAPRRGATRPTGQRKPSTGNAGGNQPKGNGQAAAPAASAFGGVHVGEKIVISGLPTDVDKPQVEELMKTTIGPIKSCNLSYDSRGQFIGVATILFKKAENATRAYYEYNGRVVDGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Y8</accession>
    <name>A0A2S5B6Y8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Y8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Y8"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="158" mass="17793" checksum="B526C2840FD4F384" modified="2018-07-18" version="1">MAQGTLPQDHPYGFWAKPKKAADGTLDMKTWETGIPGREGTIWEGATYPVTLLFPDGKFPANFYHPNIYPSGTVCLSILNEEKSWRPAITILLGIQDLLDAPNADDPAQLEAYTTFKYGLFFFAGPILRSADIQDVHRKDRSAYEKRVKQQAKDYIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7B1</accession>
    <name>A0A2S5B7B1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7B1"/>
    <dbReference type="STRING" id="741276.A0A2S5B7B1"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="395" mass="43813" checksum="DAB00FE17B49BD3E" modified="2018-07-18" version="1">MPPKKVVAEKKAMLGRPSNNLQVGVVGMPNVGKSSLFNILSRCDLGKVANFPYATIEPEEARVSVPDERFDWLVQQYKPKSEVPAFLTCVDIAGLTKGASTGAGLGNNFLANVRAVDGIFQVVRAFDDADVIHVEGDVNPIRDMEIIQQELQLKDAEWVQKKQDALKKSLRGATGTANLKDKAMKEELDTVTKVLELLESGKDVRKGTWSNKEIDVINDLMLLTAKPVTYLVNLSERDYIRKKNKWLPKIKAWIDEHAPGDILLPFSVSLEERLAMEFLDNPEGLKEELEKLGTASQMGKIMKTGYTMLSLIHYFTCGPDEVRAWTIRDGTLAPKAAGVIHTDFEKAFVCGDIMSFEDLKEYGSESAVKAAGKQAQKGKTFEMTDGLIAYWHCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7G5</accession>
    <name>A0A2S5B7G5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="7">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7G5"/>
    <dbReference type="STRING" id="741276.A0A2S5B7G5"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="808" mass="89523" checksum="BE15AFBD57D72384" modified="2018-07-18" version="1">MGAYETRSAKSRRRSVDASTRAGGGGGNRRGGLEPRQSSPAAANALLATFQRPSQQAFWRLCTPRRAVLLAALLTSAIVLLVVGFVVLGLSLPTLTSDLSVSLLAKNAFASRVHETWTGLVRLGSRLANDAEQGGEFGAPQARLSSAITPVQAGDSDGGVDDKTTSEWVRGVEPTSSSTGASKWARGTDGDRVALADGSSFVYRNQFGGTFDADPFSYEARPQASSKSLAEEWDWETDRIRGVNLGGWLSLEPFITPSLFERYLDHEPEPARDEWSLSELVRADRDLGPDLSPQERLERYLRKHYDEFITERDFADMAAAGLNWIRLPFPYWAIETWDGEPFLEHVAWEHVVKAVEWARKYGLRINLDLHAIPGSQNGWNHSGKLGPINFLQSVMGLANAQRTLDYLALVAEWAARDGVKQVVAMLSLVNEVPVMEVGETAVRSFYAEAYERIRNVTGYGAGHGPVLAFHDGFKGTRRWAHFLETQSSYKVNVRGKGKNRNKHKVEPKSRWTNGLDRVALDSHRYLAFIEPDLAPIREQVMKPCLKWAAEYNRTLSTFGIPISGEFSLAVNDCGRFLNNVGQGTRLEGTFPNATHPIYPAAAPVGACDYWERYDEWDDAMKTSLRDFALAQMDTFQNWFYWTWKTGRSSLHLSHLDSNPLWSYSLGLRQGWIPEDPREAAGFCSSHSREGVDPKPRRFARRPTDPWKIGQGLGVGLIPHAVRTRDRAVWPPRLLNRPGGGVDGSDGGLVTADLPTYAASGKRSAPLRGPIGSRKTTESLSRVGPLPACEYPDAWAGQQSWSRDEHCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7L5</accession>
    <name>A0A2S5B7L5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylglycinamide formyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7L5"/>
    <dbReference type="STRING" id="741276.A0A2S5B7L5"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="5">
        <location>
            <begin position="170"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="293" mass="32299" checksum="82B3BE49B306D2BB" modified="2018-07-18" version="1">MTTTRETRPWRITVLISGSGSNLQAILDATASTSTLADCTVTAVLSSRSDAYGLTRARSTQPTPTPAEAFPLLRWKKLAGNELKQRRDWERLLAEKIRNTKPDIVVLAGWMLILGPEFLRDLTRDWDEHDDAQTNAVPAVDSTPCCDPANHRVGAGLATPGASPYTLPAHELRGRPIPIINLHPALPGQFPGAHAIQDAYAAFNDGKIAHTGLMIHRVIPELDAGEPVVVRNVEIKRGEPIEDLETRIHQVEHDAIVEAVRRVVDLAKDGTWWQETEKHAQEELEGEQRPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7P2</accession>
    <name>A0A2S5B7P2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BMF94_4197</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7P2"/>
    <dbReference type="STRING" id="741276.A0A2S5B7P2"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="633"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="772"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="18">
        <location>
            <begin position="1015"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="136"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="536"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="899"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="984"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1054"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="901"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1007"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1054"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1084"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="POY72788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1123" mass="118902" checksum="64B21ECE3A2043AD" modified="2018-07-18" version="1">MDSRVDDAYWSYGGGMDDSDLTATLGGLSPAGAGNPNGNGMAAYTRPGGPLQRTISEEVQHALGASLGYGTGGSNANLAGPSTSGSRGHNTASSYSTFDPMDHARLSPSAFDPNSFSRQFTLPKFISGGPSDPFGLGVGVTDPPSGTGFSPLPSYGYDFGGANGTPRSENPTQPSPFYSNNAGYTSATQSYGQASASNGGGSEQKQRQAPVYPASTAGSSVASTSTSHVAYAPSMTPSIAPSYTVAQGRPSTAPSHLYQPTTAELESPVYAPYGSSVISVNPSSSTTYKMPTLSHNLPPAQPPTEVFNPAALGLPAPPAPGSSSNFAGLYSASGFDMLGVLARVAARPNPQIQIGPVDSSCAFAVVDARRFDQPLVFVSDTFVKMTGYSNEEIIGRNCRFLQTPGGGTVQGAPRKYTDGNAAWHMRQHIQAGKESQSSLINYTKAGRPFINLVTIIPICWDSEEIAYFVGFQVDLVDQPNAILDRMRDGTYVVNYSLVGNAYNSAIIRNPPMPSISSATDSNKTVSMQAIEASGMADGDDWAMADDQPEPEPEPESVSVAGNTLAAELPGSLSGSNGLVPPPRTGGNATVYQKPSPGAQMSGAYGEVSDKTDDELLSIVANRKIEALDNEIDRRAFHKFLLAQADDLVHVLSLKGSLLYCSPAVAKVLEYDASELVGATLSSLCHPSDVVPVMRQLKDASTMTNSIVKLLYRVRRKHSGYLWIEAIGKLHIEPGKGRKCVIAIARPRDVMQMNWNELRQAGGLGDTEFFAKLDLRGTILTATAGTASVLGQPAADLIGTTLLDIALPEHRQNLEIALQQAQLGAQSTLRYKVRTRRGVSEVVTKFYPRHPEVEEETRASVERAPLHISIIAQTNEISSEERKARGGFSLAAPVYTPIPGQSPAVSDADSSASGSNHSSREGSATSATFQSTFKTLVHPSSVSDNVFDELETRRPTSWQFELHQLQNMNKKLRDEKDYLIATRRKRTSAAYSDTSKSRNSGKARRTSSEAGSTASSNANRICQNCGRTDSPEWRSGPNGNKTLCNACGLRWAKSQKQSAQGSGSDSHSPAAPGSPTSTIAAFGPLSLSSTSASSDANGNPAHTSPRPFVSTLPKVEENAFSPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7V2</accession>
    <name>A0A2S5B7V2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7V2"/>
    <dbReference type="OrthoDB" id="2590746at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="756" mass="76065" checksum="AD3154FA86C8EA9B" modified="2018-07-18" version="1">MTHQGPQPLPPDLFVLVRPPPSSSRSLLDLQIQLLVPSAARAPLPTPSTSPPPPARRASPSSTTVSSIGRVHASTTSFDAIAGASVTGTGTGTGTGTGANGDLRGPPRASPGAATSTDSQSQLSRSPSLGSTRSGRSVSTSASGTSESGYTSAGTSASGRRKVTPLLNLEYHTVLPTVVTDAGTDQRVARFLKRGIELTGFAVFDPIDLATAASLAASSAPISPVPSNQGSTVASTSTAPPPPVPAPSGNGSGGFFGRFKRLGINQNAASPNPAAKVLSTLTAGSGSSSSSDGPSPYALPLLRTRSSLTSSPSAALRPVDAYPHGAAYNLSSDRGYSFQVRKWIRSEFADAPKSGLRLEWVRAKRRRRKATNRRGREADADAESEDARARTGSRTSRASSVSGRSVTDLPSPTASDVSAPALGAVDDGSTRRSSGEGDERPDDDDEDEEEERAWICSLVYPMSTPLMPRPSGEGSASAPASARPSTSSRMTTGSPPLSSASHGANASSVSLAGSSAAMTSTTLRRMHLATLQPAPHHPKLVSTLLLPPTLPSIPIGGSYSPLRGFSGGGVLGPEDLRDLAMCTAMWVAVREGLGALEGVVEQLVGAADPNLTAVPSMADVQHGPPSATTSRAENRKSMESTRTSASVVRPGSGSVPSSAGGSPTDGESNGGSVSKGSRLGPSSVNGGGGNNGKKANGGGGSAASSSGISNAASRVSILFGGGSIGRSAGSGAGGEKGNGAGTSLGLRERWIAATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Y1</accession>
    <name>A0A2S5B7Y1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Y1"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="271" mass="30984" checksum="97402F0B886F18D9" modified="2018-07-18" version="1">MRPHHRLDLCQPGPVCPARRPVDVPSYARIRHRRPLPGHRPEPPRFGFVPPSRRGVVPERDHDRRLEAEGDVPRSERVARGDGGQEPTWVLSRRRDRRHQAVQPRAAHPRLLWPKRHPASAPPPPHAPRLARPLPALSQPRHPPDVPRPEFSPRAQFEERVPRCGRKDVGDGARRRAREGTERVGAAACGGTRGSQRRRRGASRRGARPTGRTGSARRRQGRRGPVTLHRAERPGRATRPRSSRVSPARPRRDPERRRHARQDEVDRQHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8S8</accession>
    <name>A0A2S5B8S8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_3795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B8S8"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="923"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="957"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="983"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="331"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1152"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1215"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1216"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1268"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1331" mass="144597" checksum="BB005DBBAEC8F4B6" modified="2018-07-18" version="1">MSYPSRNPNGPRINPAQTYEADPGAFHSTAYPSSSGYTANPTAMYGVPGTAGSRGPPPGRAPSSGNVLRRPTVRGAQRGTVRDADANPYANGPAPGANGGPGPQRGLTRGKTLTRPDRFVAPAPLIAPAGLGAAGKQGGKVQTKLVNGVPTLVTREPWWQPWSLFVEIVTFWAPRPVLRHFGMTDPVKQRAWKEKVALCEISALMMGIIGFITMGLNRTLCPQSGHNSANYFQRIGTEPGFVGIAGWNLQVSARTPSAIASIGNSFGGSDITGMFDRTAVSFPACNGFKQRWATVGLCTDSNEANATSCAFGAPSDSYLSSLGLKNTTRQVGYNWNQITNFTNYFVLDGNVLNLTPYMNAYPAPIKNDPVDAAIRTMLGNSTGGSRDGTRIFHNTNELKATTKCLAQRYYAGHIDKITPGCFVANLFLYVSLILIMGIILARFFMAVIFSWYLADRMVAKPKNLRRKVVSPAVLPEGANIDINNTTGAAPWIESHLKRQQTQRLKKGGGTAGRRNAEKALPMSPNLDEKRASSDFNAPLGADGMISMAAIGAELFTVCLVTCYSEGYDGIKTTLDSISGTTYSDARKLLFVVCDGMITGSGEKMSTPDMVVSMIERDPRFGDPQPMSYVAIADGAKAHNQAMVYAGHYTLVPGHRTPIIVVVKCGAPAEATEPKPGNRGKRDSQMILMNFFGHVTYNDRMSPLDYDLFRKTQSLMGVTPDFFECCLMVDADTMCYPESLGHLVRVMQNDNLVMGVCGETRIANKRQSWVTMIQVFEYFISHHQMKAFEAVFGGVTCLPGCFSMYRIKARKQDDGDWFPVLVAPTITSEYSQSTVTTLHQKNLLLLGEDRFLTTILLRTFPNRKMMFCPKARCRTVVPDTFRILLSQRRRWINSTVHNLMELVLVRNTCGTFCFSMQFITFIDLIGTIVLPIAICLTYALIINSIISPPNSFGDAIPLILLVGVLGLPAILIVLATCKFVYVGWMLIYLIALPIWNCVLPLYAFSKFDDFSWGETRKVSGEAKGADDHGAAGGANAASAVPLRRWEDWEKSRLRKVRREEKRKREFERQFGSRAVHSRSSLSTFVDSETASSYGGPDEDRWGAQIGAYNEDSGSVNLPPAVGLYSVEELDDDDNTLDQHDLVNVLDGGWDDASPLHSPLNGGHSVSGYSTPSEQLHPHAGYRQSSSQGHGSQVYGYAKPAPMRGWSLSDGPPMLRAPSSSSVLPLNHSSSSLSSVNSGDAVDPFTDSSQNLTGGVQPPPLIVPDYASLASGASTGIDSSSSSHARQRSLTSSPEARRGDPLLDGGITPSPTRAARGFDWPPNNGDPHGRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Z1</accession>
    <name>A0A2S5B8Z1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Z1"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Z1"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="366" mass="40427" checksum="EBDA9C02200AECB8" modified="2018-07-18" version="1">MPPPPAKKARTTVSSSSFLDIKAQISKHEDDFNKSRQSGQPTVITGGVPRQQKKLPAWARQNKGLASRAAKDQVIYEEDVGQGKDPDQVRKHLERKAAVYQKIRKGKTGGLTEAQIDALLVDFDAHADGANFSGASDDDDDASSDVDESLTVPTRLIEPDRDEPDPAFAHDPLVEYTDEFGRARMVPRSEVPRGAPFRDPNAVEMQYHGVADQAQGEEIASGAFKPGEGPDPSNVYYGDQTSFPVYEPDPEVLARRAATLAAAAAAPLVSHYDASRENRTKGAGFYQFSGNEDERQAQMEALAREREETERRRREKEELGDAVKRKRESEVEERKRKIEAKRREVEEKRRRLKAAGDAAGSGTSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B924</accession>
    <name>A0A2S5B924_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B924"/>
    <dbReference type="OrthoDB" id="2528763at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="341" mass="38139" checksum="4EDFD4E5ECD64EE8" modified="2018-07-18" version="1">MSSSAAFWRAASPTRKCGAEVPLEARHARESVLVSCPTSLPCTWRLLHARVHMSRPRRSLAVTSYADAESSSEDESPNTSSRVPSKRGRVLRYDDDSDSDSGAAEQTRKVKRKTSRKKTKVDFTKLPVDAILELLAVPGGSALRTSKSMYRLLTDGAGAIWAQALARAELPKLESSFVKPWQYAEMVLLKKCTIMSGADKTVSVVQRCGSTQFIPDFWVLRRNCRKCRTAGMFRLEHHKKHYPDAHPSTRLCVLENFAFRDDFDALDTHLWTLQAQDDADASLRKGTSRARGKAGPSTGVSRVTQFVADRQREKKILLEKDVPALLKRFDNEFCKFGSVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9I3</accession>
    <name>A0A2S5B9I3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9I3"/>
    <dbReference type="STRING" id="741276.A0A2S5B9I3"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="788" mass="88228" checksum="53FAD043590425B4" modified="2018-07-18" version="1">MATTFQQPTAASAIAEHLSTPPSLNRIPLLRQRIQKERAQLQQTLSSRAKDQVDLVKHGLAGLKAAKDASDQLKEHLRQVEHLMLDPRGHVQGFGKLVEVSVVHRRLTQTLEMVESLRSMYSRLAHLSQLLAADRADPLGPSPNLLTVHYHLTELETFRNETLAQAKRAGSGATATLLAGTVADTDTTTASEASQIGTSTTRETLERYFERLGETIEAFEAHYFRLARDLLVLARAGHAAVAVKLAKIAELEGVRDQKAIAIRMVKKAGNVDVASRFRSLQADARTIKHYRSKTLDAIRDACKTRVEKSYRDAGEDGVTWLDEIDWVYDDILTVRDLLTDKFPEDWHFHIGELTSNTSAGSVKAYHKALYDFLANLTTSNGVGADTLLRLSQFPREYLKTMTKELEIDGDLLKPPLLDGREATLVEDYFKLISERMDEWTANLMKTEVADFVAREQPPETDADGFYGMQGAVILFQMLNQQVDLALESNQASVLARVVDEAGRVIGGVQKQWLKILDQEYRKKVQGADGFPPGLDLYITALANDQIKSADFTEALNARLEPLVSTKYKGPIADTLNQAMDGYLDVAKRCVQILIDLVFDDLKPATKTFMTQGWYTTATAQPGSSAMEQVVETLKDYMADFQEQLNPNLFDLLIEDILDTFVLAYLTAIKRTSKLKIPAACDRVRKDIDLAFGFFVQYKPHAELVSYFDVLESVLTLMSASKMMVFLDYWPFRKKYGPALAFTEALMKARDDLDRSAVNEIMESVKRKVASEKLDEPDAPSIFDRMPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9J4</accession>
    <name>A0A2S5B9J4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9J4"/>
    <dbReference type="STRING" id="741276.A0A2S5B9J4"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="964" mass="102913" checksum="076C95ED694FCA3A" modified="2018-07-18" version="1">MLGWSSQLGNRLFGPDPKLEFRKPGQGLDLLAANQAIPPESEAAIPVLAPIESSRKLTACSQYLTLFDSPTDVVLLLPASQLDRALRSNPLNLVTLIRYCVQRLEKALTSGHVGSSSDDRERQVLNAVRVLSCVVPLVLAPREPDGSVDEFEEALFWSEDESEGLGQSQGDDDAREGQFVLADEDEEEGDSIEAQQSRAAAPPLAKRLLGALVDLLFLPGLTLPRSIASEGAGVVHAIWCAPTTPLPPPPISILNARLEILRLLTLLVSLPSVLTAPGLFLSTPNRWRDALVSGRVVNGNGDKKVVLCLLCSLLNTALAASSTAATRAVTESPTSTFDSLRDRAARLAAETAKTASAATGLHAADEASVKEALVDASLQLLGAVLIEHASDEATVRNNLFEYYVSRLHRPADFELLANGFTGSLVAALVAVSSAPGLGFGGRTFSSTSPHALEALTVLFRLIDSNRKFSQWLVQTPMCLLRVMVTIEASLVEWASDESRVGLVRLASLAMQTLTAEVGAQPSDELLRALNAPLEPRVIGPALAGVVQRQLAQQGLEADAAPLTDSKTEPRVFTFNEYLLISLHALVLPATITTGAAGANYRATLATLYSPLLLAVNNLSCLMREIGNEAATRLVRVWLAFSAPSWVLMEEGNPRLVYCGSLKGAIRVPLYLLETFNNVTAHNLDRNPYIVYALAVSFPRLELLANFTLAVGVTEARRLKSVRRERLRPISEASDAIEGPPRPITDSAGPSAKALGKRRASSVSLSGLSLNEPTLPSPALSRSGSSTSLGASNSRPDSNEPFVGRNGFVPTESWVASWREGLPLDALLILLSEVRQKLIDCSSDFPATRPSTSTIASLRADLVMPAIKAMLPTDPSTKTRRFVASASSSSWLASVVYSRIYLAQIDYLRDSLPVQLFAVAHAPKRTPRLGQIGVEMERVGRSAAQVGGRVGGVLSGVLGGLGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA12</accession>
    <name>A0A2S5BA12_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3147</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA12"/>
    <dbReference type="STRING" id="741276.A0A2S5BA12"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015477888" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="208"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="461" mass="48826" checksum="1D714266BC772CD9" modified="2018-07-18" version="1">MTTMFALLSLLPLLATIGQALSADQIRSVFGTSDLVGATKTLPRFNFSVVANASHALYVLNSSTPVDQIGWLGTGTGSSMGNADYIIAWPHVSGSSANWTISHRIPGHSSHDMPQLASSSAGTDTQAYYQLVPELTTTDPSASYGAVAFLRPLNVGSSYPIKSSAQAALNSDPTEFVYASGSKNPGSANEGASFAQHDQAKGSTSLNMTMPVNLAAMVAGSAGPNDSTSSGSGKGSHRNILIAHAVLGSVALVILSPLAVLIARFGRDRMAWFPAHWVLNLVSAILIIITFALGTYATGNEFNDTHQQLGLAIFILVLLQATLGLIGHRTQRNRLTSSRPSYASYSFLPSRPSFPFVRLSHVVLGLVTIGLGYWQIETGISDDGEWQQKMSGSVPKAVQVIFWILVAVEVAAYVLAWAWHIGARVKKGPVKGAAARDGRASDESTLMDDMPPPVTAKPSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAI8</accession>
    <name>A0A2S5BAI8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BMF94_3324</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAI8"/>
    <dbReference type="STRING" id="741276.A0A2S5BAI8"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 22" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="60"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="248"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="527"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="625"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="716"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="794"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1168"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="POY73784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1274" mass="142979" checksum="F2CE914F89C99898" modified="2018-07-18" version="1">MAASYDYSQQYSTQDSYADDGGYGAGDAAMAGGAGDGDYDDAITQEDCWAVISTYFDEKNLVSQQIDSFNEFVNNTMQELVDESSSLILDQNMQHSGKTGDQTKRYELNFNQIYLSRPTQTEADGTVAPMFPNEARLRNLTYSAPLYIDIKKRVLVQESDEPDPETGELAWTEERDDDDVDAGEEEKIYIGKVPIMLYSSFCILNGLEEKDKLELNECPYDQPMNLRQGGYFVINGSEKVLIAQERMATNRVYVFAKAQPSPISYLAEIRSAVEKGGKTISSLQVKMMRRTERQSGQTIRSTIPYIRQDIPIVVVFRALDIIPDKDILDHICYDRNDSELFEMMKPCLEDAFPIQSRDRAERAFASTTTTTTIQVALDFIGRRGTVAALSRDRRINYAQEILQKEMLPHVSMAPGQNTKKAFFFGYMVHRLLLAALERRELDDRDHFGAKRLDLAGPLLAALFRMLFRKLTKDVYRHLQKCVETGKPFNLSTAVKSTTITNGLKYSLATGNWGDQKKAMSAKAGVSQVLNRYTFASTLSHLRRTNTPIGRDGKIAKPRQLHNTHWGMVCPAETPEGQACGLVKNLALMSYISVGSPSAPIVEFLEEWGMENLEEFSADIAKATKVFVNGVWQGVHRDPAQLVSTVKSLRRRGDIQSEVSIVRDVRERELRIFTDAGRVCRPLFVVEDQQLVLRREHIDALGNEEPMSEEDPPKMKWADLIDQGIIEYLDAEEEETTMIAMTPEDVDMSRQFAETGTVTATANIDSSATVKTTSGAKTHTWTHCEIHPAMILGICASIIPFPDHNQSPRNTYQSAMGKQAMGVYLTNYQVRMDTMANILYYPQKPLATTRSMEYLKFRELPAGQNAVVAILCYSGYNQEDSVIMNQSSIDRGLFRSLYYRSYMDQEKKSGTMPIEEFEKPTRDTTLRLKHGTYEKLDGDGLVGLGERVSGEDIIIGKTAPIPTDSEEMGQRLKTHTKRDVSTPLKSTENGLVDQVLLTTNSEGLKFVKIRVRSTRIPEIGDKFASRHGQKGTIGITYRHEDMPFSAEGITPDLIINPHAIPSRMTIGHLVECLLSKLSTITGNEGDATPFSEVTVEAISELLKQYGYHSRGLEVMYNGHTGRKLQAQVYLGPTYYQRLKHMVGDKIHARARGPVQILTRQPVEGRSRDGGLRFGEMERDCMLAHGVAGFLKERMFEASDGYRIHVCDICGLTAIANLKKQSFECRACRNKTAISQVHLPYAAKLLFQELQAMGIATRIGFEDKAAHNLSRQSAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAN4</accession>
    <name>A0A2S5BAN4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAN4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19374" checksum="29B548AE3F6A3299" modified="2018-07-18" version="1">MFSSKDGPVDVDAPIAAAAAAEVRQIDDLPEELKTEIARYCYEQDNKDRELSRRALLRPAIKPVESLGALFRTSRTWSRVVSFKQVASAAFRLDNAPARGPLFRHVSGTQVGPSSVSDWRKYIGVLPSLPNVSSVDLYLFGDFLSTTFDRPGHYAVKGDCDDAPSIASSEEVRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAR9</accession>
    <name>A0A2S5BAR9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAR9"/>
    <dbReference type="STRING" id="741276.A0A2S5BAR9"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="392" mass="43527" checksum="379F975ABFDF5B12" modified="2018-07-18" version="1">MATPAQAATPTPTQTSPADKGKQKESPRATAMIVIGMAGSGKTTFMQRVNSYLHSREQPAYVLNLDPAVIHLPFDANIDIRDTVDYAEVMKQYNLGPNGGIMTALNLFTTKFDQVLSHVENRANEVDYVLLDTPGQIEIFTWSASGSIITDALASALPTVVVYIIDTPRTTAPATFMSNMLYACSILYKTRLPFLLVFNKTDVQPHDFALDWMRDFEAFQEALLERRQTHGEEDGPAYMDSLMNSMSLVLDEFYKHLRAVGVSAMTGEGMEELFDAVQEAREEYEKDYKPELEKIIAERKRKEEAKKADSISRLMRDMKVSPSGQSAAVPQSALDAAQQGADEQDDEDEDDDDGEVIDRSARTDYYQLPERRRGTGPGGAVEGEDGTLWPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAV1</accession>
    <name>A0A2S5BAV1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAV1"/>
    <dbReference type="STRING" id="741276.A0A2S5BAV1"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34294" checksum="13BE0C3E4A46033B" modified="2018-07-18" version="1">MQSWKSFTTQLSSVAGQAASTVQGATQQIDLNSTGKSLSQGFATLNQTLREKTGQTQQDDVTELPQEYLDLERRVDGLRSAHVKLLRVAKAFEGHYDYPVNLGESASEIGGSLAHNLSAWAATATKGTHLPQPQKPSEVQKTLPHALSRAAASGAVEVGPGRLANVLKTYAVTQDKVGTARTRMDDDISKNFLQPWSATLNSSIQASMKARQNVKSARLALDATRAQAKNATGARLESSRMEIEAAEEKLVDATEQAINLMRQVLENPEPIKNLHALLVAQQQFYAEASEAISSVLGEVEEAGTAAEADWRKSRDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB12</accession>
    <name>A0A2S5BB12_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000031">
        <property type="protein sequence ID" value="POY73954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB12"/>
    <dbReference type="STRING" id="741276.A0A2S5BB12"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="226" mass="25083" checksum="223346BE87B0D58F" modified="2018-07-18" version="1">METLNDRAGFLSNYEVLRLLRQQQQDRIIQLKHLTGGKIGDVGGNGKDGKRPRYQDIAQREEAERIQPQDLHTVSWEAVQYLEADVHPTRRQSRDGISHLLDGLAADFKLTKSERLQIVNLAPTSLVELHVCIDDLADRYTDEQQEALLDLVRSHLSSTAAPETSASLKQAAAQLPAAAAEAPDLNDVPDETAEELDEEMAFIDEAYGGVRANEQVENDIDEVGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBN8</accession>
    <name>A0A2S5BBN8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBN8"/>
    <dbReference type="STRING" id="741276.A0A2S5BBN8"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37752" checksum="1F27156673694CCB" modified="2018-07-18" version="1">MSKYGEGKDLPNLEMLKSHCFATIPKPEGNLTGRIALVSGATSGLGYATALHLARLGISTLVFPVRSLKKGEQYVQSLHKDVPSFRGKVKLVQVDLCRLDTIAPCVAQIEKEIDRLDFAILNAGAARTNFTQTPDGYEETIQVNVLSTGLFAVLLLPLLDKTASLPQPSGAVPTQLKPQLEIVASDVHYWARNDLFPRSGNFLEQINSEAFFKTLPHAEMYNISKLLDVFMARKLAALPATEKIQVTSTNPGLCKSALRDDFGAVAAWLINQISWSAEFGTRTFLHAVLESHPSGSYISNGIRRPTSTFACSEEGIKLEDQFFKELVDLYAQKAPETKEILGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBQ6</accession>
    <name>A0A2S5BBQ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_2771</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBQ6"/>
    <dbReference type="STRING" id="741276.A0A2S5BBQ6"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF5">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="15"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="159"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY74197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="432" mass="46670" checksum="6B4D29BF9C52E856" modified="2018-07-18" version="1">MSWIKIDADSPFSLANVPFGICSPTAGASPRAATRLGDHVVDLAALAKAGLLDNALEQGERHVLEQPTLNALAALPAAKRTAIREEVQKLFSDSGKPRFEKAFGSSADSKALYDVQDVTLYNPMAVGDFIDFSVYPAHGLGAGRAIFGPDTPLPPSFSRLPMAYNGRAGTVTISEEIVRPQGQTRAFSAQREIEIGECKALDWEFEIGAFVSQSTEDGTYLTPETARSHIFGYVLLNDWSARDIQGFEMVPLGPFNGKSFATTISPWVVVPEALEPFAAKRPTSLNGVEADIPDYLRESDGAATNYDVECKTYLRLSSEPSTAHHISTARFADAFWSFPQLIAYQTFNGSRVQTGDLLGSGTISSQGDNAQGCLLEKSQGGKVPFKVGNEERRWIEDGDEVVFEAVAGEPGKKVGFGQLRGKVLPASKLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC30</accession>
    <name>A0A2S5BC30_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC30"/>
    <dbReference type="STRING" id="741276.A0A2S5BC30"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="673"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="741"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="843"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="906" mass="97448" checksum="C8D6B69F2B052274" modified="2018-07-18" version="1">MAARPHSSLPTPLPRTATAPAQAAYPTPSLAAVGPTGTLLRSLAVAALEYSPRSAAFLAERALALETLSEPSTCLLARCYLAIDSPHEALWLLRQPVLVFDPSQPGDRQHPSHQQPMASRRPLAATTSSGRLIRPANECSVRCARLYGEACRKLRRDQEGRQVLANISRPGTVLAPPVPFDSPDLVAGMPRIDESVAIQLEMGRLAKRAGENERAIQSFTYVVAKVPTCWEALEALCELGAPPNIDDILPATDDVVRQVTRAATASQGVEDAGAVPFQPYLHSPSPLTPSQTLVLNAPSDYVHNTRQRQEGVGLVTPVEIGVKMGDAAEFLNKGKGREVAGAPPPLRRAPAGRTAHYASNMSHDDSFDTTFYPATGTLTFAPLQGSATATSHADMLALNAADLGRLAPTATGVKRTRAGTLAPASAHLSNLTSAAREDDETRTSSKRAVRGDGKPRRTDANSGANGAGTTTRRSTRLSGAVPAQNALGASMAVTRSQSSSGTRPASQPRDKKRSKAAGGPTVLSDNSSDPMHSLSSSPIPPSPGRAGPTVSLDQAGAAMLREEAERYAAFVCRHFALALAAVSTRARAAVGEALAVLPAEQAQSVLAFTLLAKSHFDAMQYANAATCFEQVRQLAPHRLDGMDVFSTSLWHLRQPTELSYLAQDLLAIYPRHAAAWIASGNVYSNAEDHPAALRCFRRAAQLDEDCVYAYTLSGHECVVLEEWERALGFFREAIRRDSQHYNAWFGLGNVYLKTGKHALAEYHFRKALELNPANATLACCVGTVLEKLGRREEALVLYDHAKAVAPESALARFKRVRLLVRLKRHEAAEADLLALQHEAPTEPNVLYLLGQLYRNLNRRPEMLRMFAQAQDLEPRIAGLVRQQIEMEGAAEMEVDDGSEATSVAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC33</accession>
    <name>A0A2S5BC33_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC33"/>
    <dbReference type="STRING" id="741276.A0A2S5BC33"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="556"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="895" mass="97904" checksum="63A0593068D7C3C0" modified="2018-07-18" version="1">MSSSSSTRRDHSHHSHRSRDARDRDDDGQLPWWELDRSTAPTRGFDSARRDDSTRRRGYDSDRDAPYSGSGGGLPYDRDPARDQFRDRDRDRRPVDVVRAPPAMTPRERERAPDPIPSRRRHHLEHSHGHGHGHGREYGHERRREGEDGFTPHAQRKVAHHPPPSSASLAPSSLSPDSGPAGSMMGRPGDSAVEEGEIPRSAQTHTGGGDDDIELSLEPVTEPDPEQILAERRRKRAEILAKYASASASASASAASTAPPSATSAAATPEPGASSNVVSGLKREGEGAAAAAAAAAAVAVGGCGGGGAGTPGRSEVERAAKRLRIQGTDSPAAAVAASTPGFAPTPTAASTPGLSTRSSRSVSVDHPMGAVSAAAPVVDPNSDASPSTHDHAFSLEKDAETSKEELTALPREDEADEISAADYDPDRGDDDRRRVHGQGHGHGHGHGNNAGETKKEDGGVKVESDDEEEEIEVEEEDEEDEDDDDMFAIGTADDKPKKTKRVVKRKKKDHANVPLVNRALPSAADSTNPSLLADNYDDPEGYYRVILGEALDQNRYHVVAHLGKGMFSSVVRARDLGEKGEGRYEGEEGRGLGGKGVGEGERREVAIKIVRSQESMYKAGLKEAQILRKLRDADPDDKKHLVRLHRTFEHRGHLCLVFESLSMNLREVVKRYGKDVGLNLRAVRAYASQMFLALALMRKCEIMHADLKPDNILVNESKSTLKVSDLGSASDVTENEITPYLVSRFYRAPEIILGLPYDCSLDVWSIACTLYELYTGKILFPGRTNNHMLLLIMETKGKFNHKLIRKARFHDQHFDDNLTFLYTEKNDTITPRAIPSKPSSDLRSRLMPPGVTRRLKEEEGRLLTHFVDLLDKMLSLEPARRPSPKELLNHPFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC56</accession>
    <name>A0A2S5BC56_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC56"/>
    <dbReference type="STRING" id="741276.A0A2S5BC56"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF333">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 31 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="240"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="777"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1076"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1120"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1143" mass="123628" checksum="4942AC83F23B7E4B" modified="2018-07-18" version="1">MLPIGQGFTPVTYPPPPDYDTSTQQGANGAGGGTGVAPFAPSHYRSDSASRLVDLLNNDSDILSRPSSESLQAYSDAYDSATEGTSSLASSVRSRSHARRVSPHTGAHHVGHRTAPSSSASSSALVDDAVASASTTSTPGHYGAPWSGDEFTGASGGGSSTSGGLYYGSHVSSRVPSPAPTPDGFDGYLSYRSANRNRSRSPSGYSTPVTPADKEEYFSNHHHATSALLRKVGGALTPDVAPTIGRKDQNSGWWAKRAEQRRRRNSDATDDDGTAPLLGTTAGVSSKTGRDRSCLAMAWSAFLRQPWVPTKPFTILFSLLLFGCFAATLTTFLVNVLSSDREPPPWRQYCQEQRQFPHDLADSLKPVNVFVGIFSVDAAADRRNAIRLTFGKHSKPVDPRTGRPAHNVQLKFVIGRPRPKWSKRIALEMEMFNDLVVLDIEENMNQGKTFKYFEWASENATVPVYYSRKGDAGVVDGVRQVAVGFKKADYVVKADDDSFIRLDELERHLRITPRENTYWGYLIRNRFMAGEVYALSADLVNYVATYPRPNSWRVGKEDQRMARWMRNHPNASSIHWISERCWIYDHPKAGTTYSRGFTFPDHVEQIRAEGRRGITEEERLRRGGEYWQSYSTVSKWRQVYRPPTKELSIEEQVEALIEGGGRWQAQGWRSDNGRGPEAVHVDRLLFDNTDTRLIPTDYDGVQRATRPNPTAAGVKPGAPNIEANLPTARTTHFGKDLFRDPDSLQSVSYLRKRAANVQEGPTRPALGEGEYEVHNLVHGPFEDGPAPESPATGGGNSSTSAASSAAGATPSTAPVAAEDGEEEDPAANEPTSQIRIGQHAYTVPAYDERFLPSPSLRFDPSTLSVREKRMLGRSNGGTVAVHYLKRNEWFFETALALIGRDRMWDNGVDAPAYPDSPYSTNTLLEPYSKTPLAVSAVPPHAIEPSPRASDTGLPEDEIEVLPALWGGARMYGSPIVLDNGMILDGRRAEANREVLVNHAIRPVAPPQPPPQTLGEAVASRVSRITGGGRVPMVALAEMDGAEILVGGEASTADASEAAVVLPKPAVVDETPAMSQDAPSLAGSDDPSAPSASAEFSSAATSSATPTVSSSSTSPQEAPRPSSSSTPLSEADSTTTADRPSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC59</accession>
    <name>A0A2S5BC59_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U3-containing 90S pre-ribosomal complex subunit-domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC59"/>
    <dbReference type="STRING" id="741276.A0A2S5BC59"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40257" checksum="C69A7FC40BBA65DE" modified="2018-07-18" version="1">MAPAHKKAKTSSTPAAAAPVTDLGGDDLDDNFLLDDEFAAGSDIDDPELAGNGDAVLSDDAGAALDSDDEDGRPAAKKQKQQQQEGGKKRAAVEEAGEAGDRPISKRAAKKANQRKREPVTGADDQEKKQDDMGLLPVEALADRLAEKQKKALPNLSALELDEQRIIQSMIMDTSSVSDRESLLAFMKAALPTQCNTLAKMPKATGSPRIIVLAGAALRVADLCREVKSFKTKTKDGLIDVGKLFAKHFKLAEHVEYLGKTHVGIAVGTPNRIEKLLNETGKSCCFRHGGSRRCTLLTLRRCTLLTLKFVLSIEALHLTHLSHLILDVSHLDSKKRSLVDLPEARADLFKLLGSKPIMDRLREGKMKLVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC81</accession>
    <name>A0A2S5BC81_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC81"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="166" mass="18063" checksum="90B803090E3E4EFF" modified="2018-07-18" version="1">MVSERFVRFTMAPVALLTFLTSVVVMAIAASLEHRWKNVGFPNNSYRDRERLLLVAGIWGIIVSLYSLIGVLVRPTSRAFGVLVHLIFYAIAFFLYLCGAASLTALTNSIDCGNVTWSRCNVVKGGLVSTGWIGTIFTFIMLLIAIFLGVKARSGVGARKAALTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCL3</accession>
    <name>A0A2S5BCL3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCL3"/>
    <dbReference type="STRING" id="741276.A0A2S5BCL3"/>
    <dbReference type="OrthoDB" id="5594612at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="52927" checksum="A12544BB4D3FDBDC" modified="2018-07-18" version="1">MPASIRSSRSRPRPTPTTSFDTNPNASPTLTATTLASRLDLGDDGPKVIVTRADLRDSISAYEHLLSTAKGYRNALIALSTASTALAGALGECARVKGAEDTSAENLMAASGLQYMVANSGQVLSDTLYRSFEVPLMTQYDSYVNEIAARHAEYEELLKEKTARIRETEAENMRRGKKKTRDLDQFRQALHQLTEQVAEVEVCKRTYYSEVLDGESQMWAMIAGKVALLVRSTLDLSDRLASKSTSDPVIESMLNEHPDPFDSYRLDRDEADVLTVLPPINLVGSASTPVISPGKSGNGTALATVLETEQSFQADADERDESERSALPQRLARTPVSVFDILGLREPDEASRPPRLAEALHEESPHNKQDAETPPRVGRSRSRSGSHLPTPSSTSTPNSTATESPALEHSLSRSESFDEPPSLTIESAPFVPPEHVAAVETPTKPVRSGPNESVDSEDPMAGDWGAPIYGRSLSMHDGPEYDSGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCQ4</accession>
    <name>A0A2S5BCQ4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCQ4"/>
    <dbReference type="STRING" id="741276.A0A2S5BCQ4"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29949" checksum="8E4CF615C7DA5EEE" modified="2018-07-18" version="1">MPLGLMKDVALTSNDTPAAAPSGPFLPATVLATHKELPELYDYLLKFIIIGDSGVGKSCLLYHFLNDRIRDPSPHTIGVEFASTLMRLPSIAPSSTSYPAGSGGQASGIQIPASKTLKVQCWDSAGQERFRSVSRQYYRGACGAVVVFDITSRRSFEALASWLSDARTLASSDLEVVVVGNKLDQEEDRQVPYLEASRWAQEHNATYVETSSKTGENVEQPFILLARSILLAVETGKLDPEKPGSGVSYGERALRRVSSWNGSLTSGRGKLFGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCR8</accession>
    <name>A0A2S5BCR8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCR8"/>
    <dbReference type="STRING" id="741276.A0A2S5BCR8"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="56544" checksum="794F48273EAF075E" modified="2018-07-18" version="1" fragment="single">PFSTSVPESFDSSVDAAALCARFNPRGLHAGHYLAVGRLDGVVSVLDFETKEIVRWLEGHVKAVTSVAWSGNSRYLLTASRDWNAILWDLSAAAQDSLEGERKHTIRFDAPITSASLHPRNSKLVVVTLHGQTQPVFVDLREDGGGRWELEPPPDEDEMEEDADEEMETIREVSTYARFNPRGDLIYVGTSRGNIHIWDVQTKEWLWTEYVGSPTAVKHLEFNSSGSALVLNSNDRCIRYITLSPTPPAPPSDSDEEDAAANYEPPPPRPPRIPYFEVEHKFQDLVNRTPWNGCSAGNKGAHNIYIWDRETGTLVKILEGPKDSCEDVDWHPFRPLIASVSSHGFLHMWVTPVVENWSAYAPGFEELDENREYEEKEDEFDFVSSAPPAHPRRLVPPHFLSQHGLIPWCAFLQEDENAVRRRAADAQDHHVDIVSLPSRLVVVEPWPDDYDGADAYEDFVRRGADGDEADPAASAGGGSGFYPEPQLLPESMFAEAPIDSPSNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCS4</accession>
    <name>A0A2S5BCS4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCS4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="436"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="662" mass="72147" checksum="02BD730EED9100D3" modified="2018-07-18" version="1">MDVQTYSPVASEPSVSPSRLAAVTLPPPASPTRPEPGCPAADLLGRLNTGQSESDGAAEVQENGGGGGEVPEDDDESFLYPSSASDGMDDDDNGQPQPAPSFGTSIGEGSSGSQTSSQRYYSKWAPEGYEYSEGGPAESTPAKEASGPSAHGPKGPGALQAGGDIAQVPQALFLNADAILARLASFDKPTARRTDLGTASSPPQQQQQQQQQPRTSAQPLIRAAHVGEHRKGPEMLPGVQPPPPVDGPHAASAPPAPAISPDRDLKDSSADSSIESLLPRSSKSRLSIQTAVNDSSLANLRKDVESERAKVKRLDATLQEERRARCAVEDEHERLKKVVIGLRAKVEEANKIRPAFESAEYERGQLTRDLATAREQLDESTAALCQLQQKLRQVEAEYGDAVREIVRLEEREKEKFDAQEHTISSGNQLIELRLSYVDAERDRRRALLDLEQIEEEKHALVDRCAQAEQAHEKLKTAMVRYRHERDLELQQKDQAIEALRARVEEERQERSRASAPSAAVALGTAPPEAVIARLHEVMRESEAATRRLRRHLKAVMLRVDDIPSDSNSGVMSRHSLLQLATEADEIFAERAQLVLPDWMNASIDQREDRGLRSSNALLCCELELLKPIASENLSLRKENTEMHEAVRAAQAFILQLTAGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCW3</accession>
    <name>A0A2S5BCW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCW3"/>
    <dbReference type="STRING" id="741276.A0A2S5BCW3"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="932" mass="98341" checksum="C30784F727C3F727" modified="2018-07-18" version="1">MPAAPRPRRSTASASFAHLFQPIALDGDESSTDDGNSNVSKDGEEKKKKKRKTVYVPEEDSGSEFEVGEAGGKGADSDNEETSSEGSLEAASDDDDLGSGAGDSDVSGSVVGNSPPRKGKGKGGRKSGPSASAIVGNSKKGRAPVVASSSIITKGKNSDRPTTKDGPTRARIPASHPSSGISHMYEYFGPLAARGASRSLDLTSPDAGDDTVSAKASKRRRCLSEGRPTAGMNLLEDSIVDAMMDEATVNPFGVEAKSVRDASWHPGQWDILAGKERSRWGGWYPEVTVPRDTLETLSDDQADVYLPSQAYPLRPHAIHRPIGADEDVDGTQEPSDMADDDNLELPQLPPDFQESSSHTGQPVAGPSGSRERSAGLVSGAGSVRVQLGRLETAKVQQEGTEIELPRFQAVRLDEYVPRKPGHLFNAGGAVGKVKWAPRADGSAEKEYLAVTTISDPDAPLRHTPANDTQGSSLRSMIQIWSVPAAPSARELHYETLGANAGQESGAMKLEIGLCVDEDVRAVEWCPRGGSADSDGAADSTATTEAEDEPVPTTTSRKLKGKARAKAAQSLNVGSDDAMNVDSETPNGVSTLGILAVVHGNGTIAIYAVPHPDQLDGEDKPTFVRAQARCKFAIPDASVVSVAWGGHEMLAGGCTNGAIAVWHVASAIRAEKQTGMSRPLHLYQAHSGVIRSLVFVDTPPPDLADRSEHDFDERPTGIAAVGYDGTVTLSDLRQPDGGTISLYQQRGPIYDIAFGAHAGVVYVHDADDRVKAFYLKPSALGSEGRVAIHTGPVLSVTASPHHGLVVSTSADGSAVLTSGVRALRKRRVRGHFSHKVFRLDFKRETGELRMWDNLETEHRAALDPANPARTAKKDAAAEAAVPGETPTAAWAAEQGVLCSAWHPSIDRCALLATGTACGLARIDWLEGTAQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCZ8</accession>
    <name>A0A2S5BCZ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_2417</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCZ8"/>
    <dbReference type="STRING" id="741276.A0A2S5BCZ8"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="446"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="685"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="997"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1093"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY74655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1119" mass="122619" checksum="DBEAC41B198845BC" modified="2018-07-18" version="1">MPSVDNMDSAAAPSALFQALYAANTRSARTAAASAVASHVCTKGIRSLIDDDILDELKRAARSKTPLEKEGAMVAFEELIRKTGLSVGAVDPYYVSLVPYILDAFQESGKTGSIKDAAEKAAKQLQRLPPPELAPRLIEELFCYLETNAKWRSKVGALDLLSMFAVTAKDQVAERLGDYVPRLVPSMQDTKSEVATAAEKTAVALCHVLTNPDIQPFVPDLVRCMADPATVPAAIKRLSSTVWVREIDGPTLAVVAPLLKRALADKGTIVQRQTVVLITNLFKLVRSSDLAAQHAPTVSPGIDRIIESAAFPEIRAFAEDAKRAVDKSCVGAAVPAVDHLSEAIADEKTALGQLMDLAEKHTGERPDAFAEISIKFAAFAVSQLVRKRALSEKEWRETYVAPYLAHFVGKDAALSISDEMLKKWVAVDKERNRVEGADDDDDEEGEVAIDLPFSLAYGGLLLLNHTVLKLRKGHRYGICGANGCGKSTLLKAINRKQIDNFPEDIKAAYVEHDIEGDETGITVCQLMIDEPRISATETEIRAMLEEMGFAPERQDVPIMSLSGGWKMRVALARAMLMKVDLLLLDEPTNHLDVQSVAWLQDYLNSQKEVTSMIISHDSGFLDAVCSNIIHYHKKQLVYYRGNLAAFVEKYPPGKTYYTLSDDVVKFTFPAPGSLMGVRSRTRAILKMTDCTFTYPGAAKPQLYNATCGVSLSSRVGIVGPNGAGKSTLIKLLTGETLPDTGRVEKHPNLRIAYVAQHAFHHIEQHLEKSAVQYIMWRYQEGIDKEQALKATRALTADEEAQMKVPITAKSGEIRYLEAIVGRQKLKKSYTYECKWQGMHHRFNAQIPRERLIELGFTKLVQEFDDFEASREGAGSREMSVKLVRQHLEDVGLDGNIAEYNELKGLSGGQKVKVVIAAAMWSKPQVLVLDEPTNFLDRDALGGLAVGIKEWTGAFLCISHNQEFVGALCSEIWNVEAGRLTMKGKSAVNDNAFESNPASGMASAVGTPGDGTPAAVSTPAGSDDEARAQATIEGAEEELKFKAAKGRKKLTRKQLKEREDRRRARTLAFLANTTPGATREPDTESDEENETHKAQKLRIPSKTKNKSGTSTPTLAGMRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDG2</accession>
    <name>A0A2S5BDG2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RTR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDG2"/>
    <dbReference type="STRING" id="741276.A0A2S5BDG2"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RTR1-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="467" mass="49786" checksum="9055A0B513AF2CD9" modified="2018-07-18" version="1">MPSLPPPKQSGTSSSGVRPRPTSHFRVQTASSSTRSAQETLPDETPNDAALRDTTALLDRFTLSTLTRAAAATAPSTLGLKLALVERLASPVVTLSGQPSDPQVAPRAKRVVVHDERTDLIRQALRVLDPSDWDDLIDERWADGLCAFAGCGTGPSTSASSLSSRGCCKPREAYIPREDRTRRHPGGGIRNVRLVGGSLVQRAHSTSTAASHADSDTWSTTPGGAYCSERCRAQSEYYRSLAGRGREPEREEMWDEMEQRRRRVSDSTERIRRNGDDGSVVDELDPSEARTATPRIGEAAVGTATAPVSTRDGNSAPAAILSRISIHEKPLRTDVKPAAPTLADADRDLEAKQAQPPSKPRRLDPSSTSTSVVRQPLSLASAGPAGASVPAGQGAHGLPPIRFLTRPREVTSASASTGGSSLHLGGGVDEDDFAHGPVLEGIGEEEVSWLEEALRERELCERRLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEJ2</accession>
    <name>A0A2S5BEJ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 69 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEJ2"/>
    <dbReference type="STRING" id="741276.A0A2S5BEJ2"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF1">
        <property type="entry name" value="CAPSULAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="68024" checksum="775D2E3206763221" modified="2018-07-18" version="1">MQHYTSPYSAPSGARLRQRQRRQRSSIALFVESPTEATSTLLTFLKRKAGSFFSLGVGILVGLFLASLLGGGQVSRLDISLNSAFASAFQSDVLTRCADRQPAAVPWKGAGVVETWTQRQGVHRNLVSLPTLEQRERVFKILSTLTGYHTRYCLRNAQKAYRRQVYERYEPLVGYEQHGKRKGFSGHLKAFVPRIARRGFFGDSDDEKTEIEQIFSHSRDGTKALRAGYEGHKYFFAINLYNSFDIIPDLFSNMFKVSAILGFQNVFVSVYENGSRDQTKALLRLFDALARSIGLRVVIRTSLRTRGAFNHRIEYLAEVRNAALAPLWELRDAEGEVFDSIIFMNDVLPCVDDLLELVWQSRRQNAGITCGSDYIFHDEVGQPVFYDNWVARDMNGTALENAPFEAVFRDMESSHRFQRHLPVQVQSCWNGIAVLDPAPMYAHPHVKFRMAKLSAGECSASECSLICNDYWNAGYGRIIMISRVKLAYDRQVWDIIHPERRNLTYIRGYHRLGGNPDDPHSDPQDRSWYGPHDRLFRQEESEAIRFRPPPKYVWCWGWDGAGDLDGPDVEPIWELMPNISVDPLTVRHDRSFTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEK3</accession>
    <name>A0A2S5BEK3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEK3"/>
    <dbReference type="STRING" id="741276.A0A2S5BEK3"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="134" mass="14578" checksum="54C4D0807CBD06CA" modified="2018-07-18" version="1">MAAGVVSISQRKAHKAHFAAPSSVRRVIMSAPLSKELRAEHGTRSIPIRKGDEVKIVRGTYKGREGVVTTCQRKNFRIFVEGVSRDKGNGATVPIGVNASNVVINKLKLDKDRKNILSRKGAAAKKSEDVEMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEP9</accession>
    <name>A0A2S5BEP9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEP9"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="286" mass="32580" checksum="BE86D3AC8721D054" modified="2018-07-18" version="1">MADVQDLTEALDGANLADADAAADAPPPGTITLFSSDGHRFHVDRQRMRSNRPFFPTCLNSRTVSKEANPFFAALWDGKQPDEAAEWLAVYRMSDKYDVKRVRPVLLLWAWEAIDVRDEFHRVRFARVGLLLGREKLVKSAAEIALRWTDLDAPGNPIFDSLDAADQRRLARGRLTFFLSQRVFARACLEASLRSLTTIKFKLKSCRCIRDSDKSAYDTPQRIWEDAQRVVEKGLKPHTDLPDAMLAEIFRHAPRLEGCTSCWRTLDEKLDLLERQWYGARSGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEW1</accession>
    <name>A0A2S5BEW1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEW1"/>
    <dbReference type="STRING" id="741276.A0A2S5BEW1"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="464" mass="50951" checksum="2C05A6BEB93E7DC2" modified="2018-07-18" version="1">MSSSGTAFDPTRWAPLGNKRAGMIAVATAASVSLTFIFAFTGWVAYLLWRHHSRVKANRVEHETRAIRFLASSHGILLGSLILGDFIQAVAFALTFVWVGKNRIPTAQHPTHICTAQGILIQIGDLGSAFSSLVICGNLLLLLVFRITPTLRWIWITLACEWALIFLLAAIGPLSRIGKGGVPFYGPSGAWCWIVQDYQHFRLWVHYFFVFVVAFFDLVCYSVIALYLRYHHGQMRQQSHLANTANISRAMLLYPIVYVATILPLSIYRIAAMTGQNWSVHVLLGAGAVFTLSGAANCTIYALTRKLVTFDGVASALRRGSASASAGTAIEGGSFLRRGSSATVSPPQPRSKIRFERNIFSLLHKEDGPRYRSDSSVGNALHGIVVEVETTNFQEGTPAPSPLLNDQDSNSKSRRPSKPEIRWHMETPAGEDRPFGRLNMRDSLEMGPSRTPSSGADGSDKETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEW6</accession>
    <name>A0A2S5BEW6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEW6"/>
    <dbReference type="STRING" id="741276.A0A2S5BEW6"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015497332" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="103"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="279" mass="29586" checksum="818A8CF74E1FC2EB" modified="2018-07-18" version="1">MLSMLLIAAIALAVSFGMRNFSLGDDGKVSVSTSKGEAGAGTAANAPGTVTQTVTSVSTLASEEAASSKVDRPSQSAGSSPSQPATTGSGSTSGGASSGEADAFVKTILDGHNDFRRKHDAADLVWNTTLQASAQKWAEHCVWEHSGGKVGPYGENLSAVVPFQKNDKFDPMSGISVWNGEEKDYDYSKPTGFTHETGHASFLSLAQRRYCSVTDNGASRRQQFTQVVWIGTQQIGCAFTTCEGFFGHPLGAFFVCEYWPGGNIVTDDLKYFKDNVKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF16</accession>
    <name>A0A2S5BF16_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF16"/>
    <dbReference type="STRING" id="741276.A0A2S5BF16"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051373">
        <property type="entry name" value="Lin-28_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109">
        <property type="entry name" value="PROTEIN LIN-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109:SF1">
        <property type="entry name" value="PROTEIN LIN-28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="4">
        <location>
            <begin position="290"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="439" mass="46097" checksum="1FC3D3AEA18A2D1E" modified="2018-07-18" version="1">MLPRARSASCSTPPKSPILFESPARDVDPAEVTPAKALREATLRHKAQPQPPPFTEPVTKMRRKRSVTLDEALDMPAQVDALVKAVDGTSLFVGGFGAGLPPTQSTSASSYPYQASSAFAPWTATEYGSGLVYPISSSRPTPPCDPSQFPAAAPWVMHDAVLDSAAPYLSFGGYPHFAGFSESSSSSSSASVTTSPPPPTSLGLDLPYGLAHGSAFSSPVNWLASGYALPLASPPLVLPPPVGPAPYARGTTLPYVGSASKRSTPASKGSAKSPRWGVLRQQIQDGLYPKSCGTCKFFNPQTGFGYIIDDRAEELATDVFVHFTGIEQSRGFRCLSPGERVEYFLTQNSAGRVQALKVVGENGAPLLGLADPVQANRVREAARRLSPTIDSGASSDSSTASSRNLTVNGRSRKPRVVPIPPSQLPANALGLVAAPDPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF38</accession>
    <name>A0A2S5BF38_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF38"/>
    <dbReference type="STRING" id="741276.A0A2S5BF38"/>
    <dbReference type="OrthoDB" id="2529590at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043189">
        <property type="term" value="C:H4/H2A histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="54114" checksum="3D17A08930E6CC9C" modified="2018-07-18" version="1">MPEQATDSTIDWAAAPVQPAASATRNEPTRPSYLDSPQGELALLRALIAHRLVGPHKHVQMVALLTRMQKDPHAKALSTTDVWAKWNELYEAGTLDTQEQLLPGSPSPSPTPDSTPSRAQSPEEADGAGFDDAKSTNVRQRSTDPPAGSSRQPRPSRIDAHYFPVRDFSLRPPRRGRLPAPASIFAAEGEEEGAEENDAQDDQEDEGDDEEEGMSLEQLAFQRGMVPPGQRAESPADGPLRHVSMPPGVSGGDGHSDQEDDQTGEEEDDGSEEEDERPSTATSSSRRGKRARTSTAAVAAAAGPSPKRRRGAAATPATATGSPSSPRKRARATAGPSSGAGSNAKNAHSSAYPDESELSELSSADGEGEEAASDGKEIDGEESGNETREAKGKRKGGKASGGDEEDEGQDGTDGESGDETAADDDDEDFAPRAATNKKGNTASAARRSGASVADSAASRSASPGVTAASTSNSTTAKTTKTTRAGAAARAKAEKEAVAASKAAATPRSSARRTGTGTNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF69</accession>
    <name>A0A2S5BF69_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF69"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="77" mass="8728" checksum="C36BBCF3D400507F" modified="2018-07-18" version="1">MRLPSSLELLQVYIPVDLDRRGRIRLRETKIIDSLKADLAACRGGSNLVVKVETVPTSLKTADELFEEIADRYSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF75</accession>
    <name>A0A2S5BF75_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF75"/>
    <dbReference type="STRING" id="741276.A0A2S5BF75"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="587" mass="65267" checksum="86E27F92B3451B9F" modified="2018-07-18" version="1">MPSIPRTATPLRHGEEPEDPADKDALIFAKRLSVRRSELGLRVAFGVRLQPTYGLLGKDLDMFSEAGFDMSKIHLKRNAPVAQLYEDAIKYEGAVIAASGALINFSGKKTGRSPKDKRIVFEETSKDDVWWGAINIQMDEHTFEINRERAIDYLNTRDNVYVFDGFAGWDPKYRIKVRIIASRAYHALFMHNMLIRPTPKELEEFGTPDFTVYNAGQFPANRFTAGMTSQTSVEVNFKRREMVILGTEYAGEMKKGIFSVMHYLQPTKFGNLSLHSSANEGPDGDVSLFFGLSGTGKTTLSADPRRSLIGDDEHVWSDNGVFNIEGGCYAKCVGLDAQKEPEIFNAIRFGSILENVTYDYNTREPNYEDTGITENTRCAYPIEYIDNAKLPCMANSQPKNIIYLTCDAFGVLPPVSLLDEHQAQYWFLSGYTSKTPGTEDGIAEPTPTFSTCFGAPFIVLHPSRYATMLAKKMTASKTRCWLVNTGWTGGAFGTGKRCPLKYTRAIIDAIHNGSLAQANFSKTPVFNLAIPDQVEGVPADLLKPEAAWSDKNSYKETVNKLAGMFSKAFERYADECSPEVVAAGPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFD0</accession>
    <name>A0A2S5BFD0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFD0"/>
    <dbReference type="OrthoDB" id="4590707at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="165" mass="18031" checksum="6E4DF01D938E1400" modified="2018-07-18" version="1">MFRAAARTSFRQSRQTFARRSYATGHHTSTTPQKSDMPWVIGSALVFIPLFFTLTSPPGVHAQVQATSPHKEEHQADVPAVRKATLAEDPKDKESSPEHAAKAEAEKSSEDETDVKGNELDTKLSKEDKPKNVAVAAKESVQNTLDKPAEETEAKADEAKEEASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BG71</accession>
    <name>A0A2S5BG71_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA repair and recombination protein RAD54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_1178</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000012">
        <property type="protein sequence ID" value="POY75768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BG71"/>
    <dbReference type="STRING" id="741276.A0A2S5BG71"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="270"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="622"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY75768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="859" mass="96348" checksum="33504B1F72C4D104" modified="2018-07-18" version="1">MRRSFIEAVKQDPTADLSKAPSHASGGGFAFKVPTSTSGTRSRQLGGTRSSTKRPRVVFTENDFYSNVGPDADGEPAQKKSKKGKAKKDDDSDDDGKKKRGFVDRYVAPPAPKLFPVYRPKAFDSVINKAFSLPGIKKKGIILEIKPTLRPLGTRQVGEILPAPMHDPLADHAIVLWDPTTDDIETQRELERLQREKLERDESEDAAATEVDRERKKVHKSLADILGIVDRKKTAHLIKKVAVVIDPRLSARLRPHQVTGVKFLYKATTGIIEENSFGCIMADEMGLGKTLQCITLMWTHLRQSPLPNKQLIDKAIVVCPASLVRNWANELVKWLGEGATNPLALDDKMSMADSVRQVRQWCATKGKQVVTPSTSSLPRRARMSKGLTRCALSPVLIASYERLRNLVPELGETEVGLLLADEGHRLKNYKNDTYSALHTINCKRRVILTGTPIQNDLKEYFSLLNFCNPGSLGNDTDFHKQYEMPILKGRDALATDKEKERGDAAMKELAGKVNKLIIRRTNDLLSKYLPVKYEQVVFCSLSKFQLDLYKWFMASPEMKALLKGKDSQPLAVINMLRKVVNHPDLIEWGKDMPGSESCWPEGYDPRDRRRGVDPSLSGKMAVLDRFLTRMSAETDDKLVLISNFTTTLDVLAKLCDSKKLGWLRLDGTQAISKRQKLVDQFNDPTSGKVIFLLSSKAGGCGINLIGANRLVLFDPDWNPASDMQALARVWRDGQKKDCFVYRFVATGTVEEKIFQRQSHKQNLSSVVVDSKEDMERHFSGNDLRQLFSLNPSLCETHDLFKCKRCKDGRQVIKAPAMLYGDTSTWNHLRNEDLGANHDLLLRAEHGVEGVTACFQYIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGA5</accession>
    <name>A0A2S5BGA5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGA5"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="448" mass="50357" checksum="2C00257EDAB54EE0" modified="2018-07-18" version="1">MDLNNFRAAVEPILDRYETRFARDSLPDQFVRGRTRTKTLGAIAIKVDERRLRAICGVLTRFAAYFGPNHIVRSAAELDSLNEYFNTVRERAATRPEEDDPDTVALLDEGALRAHVLRFGYRRLCAFVAEKNALTPSNISTRTRALFQALPDASAPGRALTTSQFNRICALFEKRMRVMHGTTATPPPGGHELDPAAVKEILGKCLPSEVDIRLQLELRSMAEVNETVQRMGADGQAIHSLLSAEFENDYLDLYRNVMTLCALDPRLYTRYKSEVQSFLEKRRGGSLDFAAWRHLREDLDRRQLDLHRLASQRLAFGSEEAFKAQLAELLLTSADVRSMLDEHRDRAHRPHAGGRSQSPVDTPLSLRARTPIRSPHAFQDQHHSTLAASHDAFGEAPASPGLPSAHMDLPDLPDLFDHFSLGARPALGLRAARHYRTTPAKWAASRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGE9</accession>
    <name>A0A2S5BGE9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGE9"/>
    <dbReference type="STRING" id="741276.A0A2S5BGE9"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="119"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="366" mass="40392" checksum="9B9D3F457F340FF5" modified="2018-07-18" version="1">MTADKMHLSTALVYGRLPEVIASLRTVFDEVIFYDVQQFSPDLANQPQPTDDELVRTDVFLGFHMPPKVKNWKQTPRLKLFQGCSAGYTHVTDTDYYRSIPKDADVIFASTIGEHVLGTVLMLTHKLNYLCYTMHAEQRWVAHKELGGQYIRDLPTMSVGIIGYGHIGRETARMFHSHGSKIYALSRNGLPSPESGYIIPGTGDPSGSLPEQYFSTSSRSSLLSFFSTCDIVVNTLPDSEHTRGFVGEEELKAMKGDAIYVNIGRGTTTDQEALVKALQAKKGDDEEESATGTLRIGGASLDVTSPEPLPSPHPLYTLPNVVLTPHMSGLSRLYGTRCADLLQKNVHRLRQGKGALNAFRGRGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGK4</accession>
    <name>A0A2S5BGK4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGK4"/>
    <dbReference type="OrthoDB" id="2528469at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="496" mass="54023" checksum="155E6B4B283778DF" modified="2018-07-18" version="1">MDALRNVKTAVQLGNLLSAYLPLLARSGNPYATLRAQIKDAVVPPQSAAAKTLYIIASAGAALDVLLILSVWLVRWRKNSFWLIRRARAHSDTYLLAHTSLLWTCFTVVMCLAMQGFAWCMYRLAERKALNMTVYWTTLPWLPGLVAIVVNCWVLATTYVLHVRSYAAGRDRKLYSPAVLQGGAAATALVLVATSVPLAIKAGIAYAVVMDDWRRADAAFGVAAAQFNGSLSEAASFSRAIAPTLFDLVERKRKLDFWFRWTFTSFSIWSFLLGAIFCAIGIAYVRALKRSLDEFKDRSATASNVFASTLRNLVLLLAGFTGFLVIVAANSIWVAALSKDVLSKGNVMELSAVVPLLATIIGTLIIALIMLYQAWTAPTVFSSSSTSSRPALFLRSRTGSQRGARGELSVHYQRFAIAASEYLPESPILSLTDEHAGTAGPFENLELQPADDASSLKSNAAYGRGGAADGIAVLRQAVTVVSLPKEELLDYRDEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH54</accession>
    <name>A0A2S5BH54_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH54"/>
    <dbReference type="STRING" id="741276.A0A2S5BH54"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="190"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="329" mass="35185" checksum="97B7BBE4B0B897D7" modified="2018-07-18" version="1">MASFNVQSLKPDIEAILSLADRSSVSAKAVRKSLQAKYPDLDVKAHKAEIDALTTAIFTAEASGEDDADDVKPTVTSPKPKLPNFTKVKRARSPSSTADYLSDGVPASSPAFALASTSAPRTKPAKPELTDEELARQLQGEFEAQARGRSTRNGGTTATTKKRATGKKSKRGGSDDEGGKKKKRKKSYTGFNKLHILSDELADICEAPALGRPGITKALWKYIKANGLQDPAKKTDILPDEKLKLVLPFSRINSFTMAKHIGPHLYPFDPVEHAHLIPPSESDLSDSGSDGEDSKRKIKTGTPSSSAGVTKANGRTKSAAEVDSADDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHC7</accession>
    <name>A0A2S5BHC7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHC7"/>
    <dbReference type="STRING" id="741276.A0A2S5BHC7"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="63256" checksum="5E0D5D4F04E02982" modified="2018-07-18" version="1">MTSPPPRTSTSRSNRDDVMQLLDSLDTYTPTPPSNRAGTAASTAPGAMPRSTSNSALRSSTGPTGSRTTAANTATGSAGSTSGNKPPPSAAEAQSVLDFLDEITQRSSPSTAGAQAGGATTARPASGLGRSSSRQSLNSSTGPISAAGTTSTTGSPAGAVRRSIDTVRTAPTQRTPVPRTSIGAAAPGSAAAKRTSVGSAAAVPRGPETTTREQAQAPSQPVSAASAASVDSTAAQQAQHGGGGGWGWSSMWNSATTVVQQASNLAQQAKSAAEEQVKTATSQGAGGIAGIGGGLIKALGENEQAKKWSEGVMSYAKGAHLDQLGKELKSTTLKSLSDLLNAVAPPIAEHEVIEVSLSHDMVGYDGVESLVYRGFAKIMDQIEGGTLVVNSATSDDKPKETDEADDEVRNLNVIDGLSEGWKLAESSLEHLIKTTYKAPEPPATQESGVTVPVTTCPVYMRLQPCLAPLPALPSSCLPTSTPDPTALKSLFFLVLLRDPTHNLVHSSLSQSMPASWLDIPFEENEWVEDAMVEIIRRSVEIIGQEYITHRMRAQTVAIEQARAEAQKTLEQHQTTTASDKAPRPATAEALFDAQTEADASQAAQEARVGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHJ3</accession>
    <name>A0A2S5BHJ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 25 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHJ3"/>
    <dbReference type="STRING" id="741276.A0A2S5BHJ3"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="49977" checksum="9CDA23E8BD11A59C" modified="2018-07-18" version="1">MLAPTAASPWPGRLLLVLLGGVCTVVGLVWLTTGATSEPTTSTTRWQRITNAGGAPSRVKQLPLYEGTDDDLGMAYRAHLERTTSLPAQLLHSPTLTFDHIYVLSLPSRPDRRREMDQLARAHGIELTFVDAVNKSEPFIKWIAERAAEVRPQRLEVMARSRGVDASTLGGLHVGNDWLTPTPSPDSSEPFPPLRDPRFSAHGGDWVAYLEANYAAGTLSELVPSDPDFRVMKALWDHKEAIEGRQVNEGVISTFWGHTRAMKRILENGDRSALILEDDVDWEWDLERLWSRMERKLPPDWELALLGHCWGKEMFKPQYLHPHLHKSSVPLCLHAYALSAAGASHLLSLLENPWSAYQTAVDTAVPSFIQFGLLNSFSIDPPLFIQRKDGPSDIQAGVGSKWRGLLMDSTADRVRKMEGLEVYESEYDEANLDPATLFRYGRGKCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHJ5</accession>
    <name>A0A2S5BHJ5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHJ5"/>
    <dbReference type="STRING" id="741276.A0A2S5BHJ5"/>
    <dbReference type="OrthoDB" id="2530339at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015664846" description="CFEM domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="243" mass="22991" checksum="652702FEC083B603" modified="2018-07-18" version="1">MRLLAIAALVLPLAVAQLPTSAPSCAAMCMQVKIQEAPALVPGIDSTSLAALCASDVFTHAYSNCLKDNCNESDAQTGASVAQQVCATASQSAAIASSAASTVASLSASAASVASSAASVAESARSELTASSSTTSSPSASSSAAESASSSQVSVSSSIEASLASVTSSLASEVSSRVSSVSSAASSHAASLASSASSALVSASGTTGNSTEGGSSGALVHAAPALSAVVLALAAVPVLVFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHP0</accession>
    <name>A0A2S5BHP0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHP0"/>
    <dbReference type="STRING" id="741276.A0A2S5BHP0"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="318"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="560" mass="60904" checksum="94EDA805C76A79A7" modified="2018-07-18" version="1">MKSANESLTTFGDGNADDDRLVPLRVVLRWIKQLRTVKKAYNFAGRHLKLSGSGKWALAAPDDSITLYTVDNLIGQAILAVPVTTLARAEQSLLTKCRIAPQDYADVMDRAGVYAILPPHRTAVRFANKDAFRERLHADFEARQARAVGKGEIRPASASEPTGANVEGSAGTSKASPVAIETRPGPQKRASSALSPPSPPSPPLHPDPAVEAATPATLRSTALPPTKKARPPLPGPAYSSPAVMRTAASTPSVPGPPRPTAITRPPSPAQVPLPPATAAVFTEAEQIAAAKHVAVKAFELEALRLAHEAAVREGAGAFLALDVEAWEFDHDLLLEFGWSILEYVKDEKTGKVTARRETQHVVVKENARRRNRKFAPDARDHFDFGRTITLPQGTIYHLLSGLFSALSASKPLFLIFHDPRMDLSALRRLGFDSAADFQSDLRQLGKPVSNRDGEHGIWVVDTQALFSGWLKRKSQIGLERACKEIDLPTKRLHNAGNDARYTLDLFEHMMDRSNSPSAASTLIKTIDDRAAAAAIAKQKRLETGADILREKFEQKALPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHP9</accession>
    <name>A0A2S5BHP9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHP9"/>
    <dbReference type="STRING" id="741276.A0A2S5BHP9"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="412"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1256" mass="131661" checksum="363893DFD1F22831" modified="2018-07-18" version="1">MQADILPPDPDPFATDWLALATGNAPLSGEDDTASSNDPLAFLNSPSRLQRNLPEMVPSATDDRPFSGMTADYSWLQAGESLSASTSAGSGSSSSASYADQNASPFAASEMSFSGGYTSASDFSSMFEPTSPFSSGSLFGSNVAAGQPDFTGDFDPGALQALFAGPMGAGDSGLGSHRLPASASAVAGVPMQTVSPASTSHLSPQVITLPQLPASVEHAPLDGGPTSSRGQSPPFAPTASTSAASLVPVRAGQLAGPSASHSSQHRPFSSLAATAGIVLPAMPGVELAAVTEAPLETVSTRPAQVPEAGAALTPSIRSTGRGRPAQARGGKRGAVAPNPVDMIANAGLGQDVHESAPFQLLGNANFYSDSRPPSRAASISSASGRARPTKGGAEADEPEDASKAAGRKGRKKAEGGHNAVEQKYRNSINSALAALRDNVPALSHLKPLPSVSSEDDFDVTLNLILTRSFFLQMPTTKRKASQFSLASAAIPETPEGLIDGIPAARTLSKGVILNKAVEYIDFLRYSRSAQNEDLDLLKQMVREMVGDGSRLVDEFERRQAERHYEREVERKRLLEEDEQADGASGEEEEEEEEAPAPVAVAKGRAAGGTKRGRPASSTPASKKARASTRTKAPPARGEYEHPSDPQATQHDPLSVQYPQDGSGHPAMHAFPPSPVSSEDRGLSPYAREPFGQPGRGGRVALASFMGASFAGGIGFDLASTAAFAEEFSAQAAGRAWTGGLFRRSTPDAVPPHVARLHPSLLSGLVALGAACLVVGLYIALRYLTGSRSSGGVPPARTKRGRALAALSVISARPTPTYGAARKNALDARRALLRLAGGPNTILLPAAIAKEALIWVIRRITGLTWGRDGVVNEQATIEEAMAWIRIAEIEATVGWKIPYLARAHTFLRLSNLSRAPTWPYVSPSTSRPAVDALISVHLLSLGHSGGAEATWSRMVERRKKSDATGDSFVNIAVAADFDDVRERIGPATRNRKDFGEPASPSDTVPLLYLAEGACEVALEDAWAKIVIAVAKSTTSQHAAQDRVAALADISDDVQVIGRIAVEGSELYTLVAMTDIFLAIFTHGTSASAGTAPAALSSARTRLARLVLETKAGGPFSRLFCASPFFQLLAPTLSSSTESLAAILPSQAVLEATSKIDLFAATVFSWLICRRSTAAVLADTTDAVKPDPALHARALAARHLLGHPRFRSRSDETRENELDEVDEAFEEARDALVDALTVVSRRAAGLRTAIDEDSGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHR0</accession>
    <name>A0A2S5BHR0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHR0"/>
    <dbReference type="STRING" id="741276.A0A2S5BHR0"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="197"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="284" mass="31853" checksum="E041A50874C20345" modified="2018-07-18" version="1">MAPTKRQRVLCLPGFGQTGEMLLGKMHRLRKVLEEDHFELIGMDPPMVFGHPSTHYGTSKVSFTLEDMYSGWWPRNYTHTFEGDYDSFNRVLWAVREYIERTGPYDAIIGFSQGGNVLAHLLPLFEKPWLHPAFSSPAPWRSRGSISSESSTTSSSMASRRNSLLSASPPDSPINGEFFSGGSRRSSVGEDDIWPIKPFKCAVLVGAYGPGDPVTHTWFDTPVRCPTLSVIGRNDAWIHPQYQVDTAAKFLNTQTLWHIGGHVFPVAKEHNIAIRDFMVKNCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHX2</accession>
    <name>A0A2S5BHX2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHX2"/>
    <dbReference type="STRING" id="741276.A0A2S5BHX2"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="175"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="418" mass="46689" checksum="3B752BF6B5A68CC0" modified="2018-07-18" version="1">MRLQLPAPIRDPLLGAIGRLELSFDVSLSIKRVKRYGWIWRRDWEYAVGLVLAVFSLSVMAQPLLFKVFLVSVYTLALLIPFTSQFFLPATPIFSWLLLFYSSQFIPKAYRPHIWVSVLPTLESVLYGANISDLLTRATNPFLDVLAWLPYGVIHFAAPFVVAALLWIFSPPGAVKFWAAAFGYMNLTGVIIQIVFPCAPPWYELREGLVPANYRMRGSAGGLARIDAIFGGHGYDKTFSGAPVPFGAFPSLHAGCSTMEALFLSHFFPKGRPFYWLYVFTLYWSTMYLTHHYLIDLVAGGSLTCIFFYYYLAKMPDELRHPTKRPVQPYRATPLTNSIPLDEESGLPKPFAHHSAGATNGHANGYGGWEGDDDLDEHGRSDAESLADEAKMYGPGGDSGGLPRPGSLQREKSAQRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHY6</accession>
    <name>A0A2S5BHY6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AmmeMemoRadiSam system protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHY6"/>
    <dbReference type="STRING" id="741276.A0A2S5BHY6"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="40780" checksum="4FF0C8E9807F7863" modified="2018-07-18" version="1">MPSTTTTTTTTRAASHAGSWYTNNRSRLDQQLEQWLAATAHPESGEPLANAPVKGCKAIIAPHAGYSYSGPAAAFAYKCIDIDPIHRVFILGPSHHVHLDVCALSRCQTYETPIGQLPLDLDTITELRATGKFQEMDQETDEDEHSIEMHLPYIRKVFEGYERDRVLWIGLAFELTPCLPPSRDIKVVPILVGSISTSSERAFGTLLAPYLADPHTLFVVSSDFCHWGSRFRYTHYHPPSSSDPKAGTTLTSRNFATATAADGPVWQAITQLDRLGMDAIAFGGGPGHKTAAQAHDEFAAYLRQTKNTICGRHPIGVLLGALAALEAQEASAGAAAGQVRAARCEWTRYEQSSRVETFSDSSVSYASAVVAFGSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHZ6</accession>
    <name>A0A2S5BHZ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHZ6"/>
    <dbReference type="STRING" id="741276.A0A2S5BHZ6"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="79042" checksum="5428A0F7F4E91FBC" modified="2018-07-18" version="1">MRHVTSSRIRAAFATIASAGWTISVRFLGRRSTLPTLLLLPAGVFFVLLAAVRSYAFLYTRRQRCCKSLSPASAPYGKLARIVKVRTSALLALAVICDTVVCGRLQLEYVVALRALLPPAILLAAPRVGYPAPAATTTAALSTLASSLVLSVAMPVTPLDPGTVAIGSIGVAAQALCWCELAATWAASTGSADAVILQSLSDLAPIGLLLSALLAFGNLILHLPAYRYFFAPRHLLPIICGSSLCGAATVALGLSLLVDAIREGDVDTTFSASSGGIYSSVLCVAVAINLPIDMAYGPRASLALGLAVTLGPLTSRRHRHVCEESLYFSESSPSTSSCSEDSYYSLPTSAKSTSANLSPFGAAALRQPVSPLSLSTSLSPSGTSERRPTRRITRSTILAAVPFGVMLLLSIPPLADLPSRPAKRPSRPAARSSAQRQYVDGARATVGRAPTLDIVFALYNETLTSFDKHVRHVKEQDALQGFRMRTTVYHKGSHLLHTPTVEQLLRLDGVDEVFTLPNLGREGGTYLHHILRMLEPSASPEGRVDQGSKPLPLADLTLFLQDHLDWSWVTDVRFDFVDARTGFLSLAPYVQSDCGFDLRTREDFPRVRDIFNMFQEDLCPPTHQLTSWAAQMVVSRERIMANPPSKYRRLLDLLEAPNEHWVYAEGADSSMWIKSLPVQWRGNMSSTNPFLGHALERSWPLIFNCTDPSLAQRCGDNTFDKDGCQCYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHZ7</accession>
    <name>A0A2S5BHZ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHZ7"/>
    <dbReference type="OrthoDB" id="2524025at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="67325" checksum="D38A42FB49EC9DB0" modified="2018-07-18" version="1">MSRAAFSWAIRSRKAVYPAAPYDLLGEDPEKNVAAGTADPGHFRSIATTRFRRLGVVLASAVSALCVVALLAKPLRGFAPLPPLVIPEPNHFLEAYLNAHFDPGKDVVMWTMATGVSPSYVPSALNWNRRRAELEMPDTVVVFCLDRACLEECARAGLRAYGGYVKDEIHIPPPSHGRGKWLKRSGAERGHTMAYIKFKAMVDMAQTSFDSLFFETPIRRAADPETPSRRAADPRMPLQGDTFLTANPFDHMLSRDDDSWDVQFTEDGNYLLNFGWVFCRAKRKALVEFFAYALSRYLAHNEWDQQLLSKMVRRLGGREWFGEDGRGHWWLCDKIGLRMHMLPLDEVRSWTSFFALPPLTARTPEQFFPYHLEMYTLREDKPSPVMHHLSGVNFANREFYPKERGWATDIDGFYSTPRPILTGPAVTTSISAGAHYARLLHLVAARLDWGLQVPSHMTLTGRNSPNGPDWTYSRSWTRFISVEAAVTNGLDLLEHDFFAHAQKHAPALVLHDWSKRRIAVRLRDFADLDELIAYLERLDVPRKRGSVIELLGFDEPLCKARTWRLDAASVRTVSPAYRHIPMCRSFHAVNIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI23</accession>
    <name>A0A2S5BI23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI23"/>
    <dbReference type="STRING" id="741276.A0A2S5BI23"/>
    <dbReference type="OrthoDB" id="2530114at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="417" mass="43907" checksum="0B3E43365E385345" modified="2018-07-18" version="1">MSCNRSGAGSRTSDTRTDADADHDHHGTGSRTVILILLRGRFPDELFGQHSIEHEQHDLEYTVQHFVGIHGEQLGVEQLLGRILLIVKQLERTSSATSSSASSSLSQSIVTITSIVTNSDGSSSTITSASSSAVAVPVQNDSKNGSLSGKTWGIIGGIVGGVAALILGIFVFWKVAKRCSNNRAMDQIAWPELQNDASGGAFSTLNPQGTRRTGGAGFEMGKDHRGDGQYYDDEEEEDHAGEIRRGGWASPRAMSPRLAYDPRMSGQFYGLGGDGQYGYGNEYGQPTPMAHGNYYPYRQEAPLPPLPPGATAGSARPTLPHLPLGSDPSSARHPGGPLPFPGSPVHSFEMAHEPTYPPRSGRPYSGSAEDAYGGYAAGISTDDVPLTATAQPPAGGGGAGPNIPYAGSAGQQHGYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ63</accession>
    <name>A0A2S5BJ63_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ63"/>
    <dbReference type="OrthoDB" id="5279375at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="103" mass="11121" checksum="06F6E228BC6EF723" modified="2018-07-18" version="1">MSNQPDNVYKPSEHDGLREDGQPDKRLSSEHGFGGDRERASEAGKAGGATQPDEVYKPSEHDGLKKDGSPDKRMSSEHGFGGDREFASEMGKKGGRQGGDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ82</accession>
    <name>A0A2S5BJ82_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Myosin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BMF94_0083</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BJ82"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
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        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="MYOSIN_MOTOR"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 17" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="439"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="943"/>
            <end position="1622"/>
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            <begin position="1680"/>
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            <begin position="1966"/>
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            <begin position="171"/>
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    <feature type="region of interest" description="Disordered" evidence="18">
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            <begin position="547"/>
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    <feature type="region of interest" description="Disordered" evidence="18">
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            <begin position="800"/>
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    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="896"/>
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            <begin position="1495"/>
            <end position="1517"/>
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        <location>
            <begin position="1856"/>
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    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1938"/>
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            <begin position="2029"/>
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            <begin position="204"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="822"/>
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            <begin position="896"/>
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            <begin position="1938"/>
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            <begin position="1948"/>
            <end position="1965"/>
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            <begin position="2034"/>
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    </feature>
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            <begin position="2093"/>
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            <begin position="2133"/>
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            <begin position="2203"/>
            <end position="2219"/>
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    <feature type="binding site" evidence="17">
        <location>
            <begin position="1036"/>
            <end position="1043"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023203"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00025586"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
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            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
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            <dbReference type="PROSITE" id="PS50002"/>
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    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="POY76831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2231" mass="242586" checksum="D3393FAB3E43969F" modified="2018-07-18" version="1">MFSSARWTLPLSRRVAATAGPGSRLVAAAPPLFSPSITATASFSTSGSPCMSVKAKRMEKRDKIVRRRTTREIRREKEEKRDEALRQHDELRRADLQSKRSEGQEIQQAVPELSEDQLEAMYDSLMSATPQDLALPALAASETPALPDPAAAAESRLERITRLAERIRAFEDEQGEQVSGNAETSEVRAPSTGPGEGTVEERLAPLSSSTTLAETASPARDILDQLEGELANATPHGSPRMNGTSTPSLAVPTGLLSRPDYEDLVLACANEGDREGVIKGLNLMQRSVSIKEGNVIEDVLAAYAVSGRAQDALAVANYARQNQLPLSVTAHHHLLTTILPSHPELAIQHLRSMEASGHTPLLATYTAVTRQLLSPASPPHLVREGWDLFGHTRLVAYPVPDVPLYSTMIQACAHGAHPSPERAIDLFIEMTDDNRLPPSELAYNGVIRACAREGSREFYYEALRYMRRMLDENVAPSRHTFHALLEGARRHGDLARGRWMLVKMIAVGGESTPNETTLALLLQTYAAYKPVATSAVEEVRALKEVESVKSSTSSRASHDPSRVPSKRPRPSATLAEKDDPAQIVSRVATDPAKSGALRIVELLGEASLFYPGPMPRTSAEIIIEARNLFLQVVDAAVLGAESPSTGATELRATLFPNVQPSTFLFNSYLAVLNSHAPFAAALDFIDKSFEKAGVVKNRYTYEPAMRRCEVARNKEAAVTAAKKVWEEWLAWSETPFPGDAEGDNAGSARREAAEWIAERRNGRHVSKMWGGLIRVLAKSFCEDEALQVLKQFRTRYPPTTVGRAILPPRGRAATGDDAEKTPSSPAPANLPALPVRIASPLYPETSPSLDPLRPPYLLFKDLRVLHQRLADVEDKAGLAVVTGVARRYQVALAEAQRTERRHEAPVRKGRKAAAAGGAAPASSRKQGGFAKADWKEGFKKKQAGVSDMTLLSTISNDSVNDNLKKRFENAEIYTYIGHVLISVNPFRMLPIYDDATLRSYRGKNRLEMVPHVYAVAEAAYYAMRSYGDNQTVIISGESGAGKTEAAKRIMQYIAAVSGEGSGGGIEDVKEMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIEFDAQGAPVGAVITNYLLEKNRVTGQIKNERNFHIFYQLTKGASAAQRETYGLQGPEAYAYIAKSGCLEVPGIDDMADWSETLKAMQVVGFTQQEQDQILRMLAAILWIGNVQFSPNQEGNSEVRDQSVCDFIAYLLEVDAGQVARALTSRIMETQRGGRRGSVYEVPLNPAQAIAVRDAFAQAIYNNLFEWIVQRVNVSMKAKGATSTIIGVLDIYGFEIFDTNQFEQLCINYVNEKLQQIFIQLTLKTEQEEYVREQIKWTPIEYFNNKIVCDLIEEKRPPGVFAALNDACATAHADPTAADNSFVQRLGGVNNPQFEPRGSKFLIKHYAGDVMYTVAGMTDKNKDVLSKDLLDLVASSGNRFLQTIFPDRVDPDSKKRPPTAGDKIKFSANALVEKLMRSQPHYIRTIKPNQNRSPSEYDSKMILHQIKYLGLQENIRVRRAGFAYRNTFEKMVERFYLLSPATSYAGDYIWQGDARTGCEQILKDTGIAREEWQMGVTKAFIKNPETLFALESMRDKYWHNMAGRIQRSWRAYLRRKEDAARTIQRFWMDKKEGIVYAQQRDYGHQLLGGRKERRRFSLVSQRKFLGDYLEVGIRDSIEGTRLRNAAGIASNETVRFSCRAELLVSKLGRSSKPSPRFLILTDKAVYLLISQAVNGQVQTTLERKIQVVTIRSVGLSNLQDDWMALNTTSQEEGDPLISCPLKTEFLVHLQQCTNGAVQVNIGPTIAYAKKKGKMATITFRKDESIPRGDVYKSSTVSVPSGAPPNSVSAPPVPRKSKPKKAPKQSAVRAPGGRRPQAQTLPGANGRGVVPPPPAGIARAPAAPALGAVTSAPVAKPTSRAAPPPPTRAPAPPPPPPAQPQVEKFKSLYNFETDQPGELPLRKDDLVEAVTKDDGGWWLIKKGNQEGWVPSNYLKLVENAAPKPAPAPVRRAPPTAPVAANAASRAPAAPPTAPAVPSTIGLGSRAGSDNAAPVSVMPGMGNSGGLAAILAAKRAQAAEENGASTPPASTGGSPAGSRPASALGKPPVAPKPKPPVPSKPGAANGRAPAPPIPPVAASVGRAPPVPGASKPAAPRPPAPPAPPRPANGGGAPPPPVGGLVKPSANDLAAALAKRAGRAQQDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ87</accession>
    <name>A0A2S5BJ87_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ87"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ87"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="85"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="624" mass="67083" checksum="F95150263857C81C" modified="2018-07-18" version="1">MSTSAGSMPTVAVLNASEERQIEAQTATRRGSTPESIATLQEAVEQNGKDDCKEDTDKVPAIPTHHANGLVDQTSYMPVKQILIVFMSLQLAVFLSFLDQTIVSTALPVISAHFNAGRSSSFVGSAYLLTSTAMQPIWGRLSDIFGRKYTLIACIVVFTIGSLACAVAQSMLQLIVFRALQGVGGGGLLTLVLIIVSDIVSLKDRGKYQGVTEITIALGNGTGPLIGGAMAQRISWRWAFYLNLCIAPGSVLAIVFFLPLKGVHGSMKEKLLKIDYGGAFLTLAGSVLVILPLNWGGTSFPWVSGPVLGCLIAGIVTFGVFLLWEWKLAKIPIVPPYIFKNVTVAAVFFVTLLAGGVILSQIYYLPQFLQVAHGFSPIRSGAIVIAQFLSTTIFVAISGQIVARIGQYKPFIVVGYAIWAVGLGLISTLDENSSVARIVGFQILNGCGQGHTLQTTMVAVQAAVERSEMSVVTSVRNFMRSLGGTIFLVIGATVINNTLRSRLGALGFDRSLVSQVIDDPTAIWPSSQSANPILRALSDTQKAQIVRAWVDGFRTLMHVLTGLIAANFVVSLLFIKRHSLVRADEAELKKLGKARIQERKEKKKRAGADGKEPTADNDLEDLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZE9</accession>
    <name>A0A2S5AZE9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_7083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000167">
        <property type="protein sequence ID" value="POY69916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZE9"/>
    <dbReference type="STRING" id="741276.A0A2S5AZE9"/>
    <dbReference type="OrthoDB" id="5546837at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY69916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="200" mass="21338" checksum="EB55C55460113F01" modified="2018-07-18" version="1">MSSTTPLNFAPYADPPDAPSSSRWAPPPPSTTGPSGAAAPSSYHSGAAIPSYANGSTGFGSGSGATYGQTGYAPLGSSALQGGSSGVGTGFETTMYRHDWESAACYALGPFGAAFMLIFEVDNDYVRFHAYQSVLVNLLLVLFHLIFYLILGNWAQYLLVVADFAVLVLMSLRAYYDSDHLSRYKIFFIGELADGWVRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZW7</accession>
    <name>A0A2S5AZW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6931</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000150">
        <property type="protein sequence ID" value="POY70069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZW7"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="605" mass="66157" checksum="DB8959BD1E7C338B" modified="2018-07-18" version="1">MSGLDPTEAQLAAVSLGIEEGTAAEKAKQDSYVVDEKRADSYASDEEDDNNGGLGPTPTAEEKLVLPRVPGPINLAAFLIGFIELAERFSYYGCTIVFTNFIQQPLPEGSTTGSAKSGQPGALGMGQQASTGLTTFNQFWSYTMPMFGAYIADTYLGRYNTVCWAVLVAMVGHVLLIISAIPTVISKPNVAIGVFAVAIVIMGVGTGMFKANISPMIAEQVTNHAMYVKTDKKGRRVIVDPAVTSQRVYMAFYLLINCGALAGQLGMVYAEKNIGFYMSFLLPTVVFALTPPILYFGRNRYIRTRPAGSILGKCLNVLRFAVKQAGPNPASWVRAGFWEKALPSRYTEADRPSYMTWNDQWVWEVRKAFKACQVFIFLPLYWLTYNQINNNLTSQAAVLNTHGLPNDILANLNPFALLILLPSLELVIYPALRRAGIRFTPVKRIFCGFMVGALAMVCATLVQNEIYKKSACGKNAATCEEMPFIDLNVWVQAPSYVLIALSEIFASVTTLEYAFTKAPKSMRSMVMSIQLFMTAISSALGFAFLSLSEDPNLVINYALMAGLAFAGGVLFAFCFRRLDKEEDQLNELVAGDAHQTDKVRAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZW9</accession>
    <name>A0A2S5AZW9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000149">
        <property type="protein sequence ID" value="POY70074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZW9"/>
    <dbReference type="STRING" id="741276.A0A2S5AZW9"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="2">
        <location>
            <begin position="63"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="125" mass="14449" checksum="689057CEA46F50D1" modified="2018-07-18" version="1">MADSTLPRGMKPHPSGRFMHLRSTLRMTTFLGFAGGFLLAYQNSSLRLWGWKENELEQTRDRDELGQLAREGKPLYGETDLPEYIQGVAHRNSMWSQLKFGVLPWFNFVNHQHHGTDPAKYKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZX7</accession>
    <name>A0A2S5AZX7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000148">
        <property type="protein sequence ID" value="POY70079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZX7"/>
    <dbReference type="STRING" id="741276.A0A2S5AZX7"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="370" mass="41833" checksum="AF3BB1758F71B4EE" modified="2018-07-18" version="1">MAADSDLFKPLPVGRMELKHRLAMAPLTRYRADLNHVHHEIAAEYYGQRACEPGTLLITEATFIDLLAGGYDHVPACHTPEQVAGWKRVVDEVHRKGSYIYLQMWALGRAAKAETLRRESDADVVSASDIPIKDGPVPRPMTKSEIKDYVQYYARTAKAFVEEAGGDGVEIHNANGYLPDQFLQSVSNDRTDEYGGSIENRARFPLEIAKAVTDAVGADRVGIRISPYSVFQSMRMKSTEEIRSTFSYFVKELRDRHPDLAYIHAVESRVSGGSIVEADRDENLDFIHDLWSPRPFLIAGGFDRESAHVAADQYSNTVVAFGRYFISNPDLVRRIREDIPLTDYNRDTFYLRGPEQKEGYTDYPFAEKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B019</accession>
    <name>A0A2S5B019_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BMF94_6898</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B019"/>
    <dbReference type="STRING" id="741276.A0A2S5B019"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="27"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="595"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="488"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="773"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="POY70124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="803" mass="89321" checksum="213AB859DF8954D9" modified="2018-07-18" version="1">MAVDRTSRAYPPLPLSLESIETIQSFLRTVILCLIAGAAVASREFAVVRFESIIHEFDPWFNYRATRVLTEEGFYAFWNWFDPTAWYPLGRVVGGTLYPGLMVTSGAIWKLLHLLSIPVDIREVCVQLAPAFSGLTALATYFFAKEVGKDGSREGTGLWAALFIAIAPGYISRSVAGSYDNEAIAIFILMITFYLWIKSVKTGSVAYSAITALFYFYMVAAWGGYAFITNMLPLHVFVLLLMGRYNSRLYVAYSSFYAIGTLASMQVPFVGFLPLLTSEHMGPLGVFGLLQLVAFVTLVKSLVPDRQFQILFKSFLALGVALAVGGLWFMTRSGKIAPWTGRFYSLWDTGYARIHLPLVSSVSEHQPTAWPSFFFDLNMLIYLFPAGVYMCFRELRDEHVFVIIYSVLASYFAGVMVRLMLTLTPVVCVAGAVAASSLYETYLDPSLPDDGDDVDSASAPVELQELAGQTEDLGALAAAIDASKTATSSSKKGKKSTSADASGVATPTKAATTKSSTPRTRRAGILGMDVRFVPVVAMTFLSFLFVLHCTWVTSTAYSSPSVVLASRGPDGQQNIIDDFREAYYWLRQNTKEDAKVMSWWDYGYQIAGFSNRTTLVDNNTWNNTHIATVGKIMSVREEVAYPLLRKHDVDYVLVIFGGLIGFSGDDINKFLWMVRISEGIWPEEVNEQKYFTSRGEYRVDDQASETMKNSLMYKMSYYRFNELYGGGPAQDRVRGQTIPAGQIKLDTLEEAFTSENWIVRIYAVKKEDNLGRDHSSANAFVGGKRRKRVTALPTLSPKSKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B042</accession>
    <name>A0A2S5B042_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B042"/>
    <dbReference type="STRING" id="741276.A0A2S5B042"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015554132" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="255" mass="27673" checksum="3E19387F12ECE57D" modified="2018-07-18" version="1">MRTSIAWLAATLLLSTSASAAVFRSPNVKLLSTKTFKQTVQGSDKLTVAAFVAPWCGYCKKLAPNYDKVADSLKGLVNVVAVDCDVDQNKQLCGEMGIKGFPTLKIFPGGKSPAEEYMGAREAKDIITHATSRMPTFVKRAATAKDVDGLREKAKSKPVSLLFTSASKVTPLYKALSTDFYRQMDFYAARDTKVGQDAMATFGVDKVPALVILTSDDKVHKYEGPLKYDKIRAFLEPFAGAKASGSKSKPTHDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B066</accession>
    <name>A0A2S5B066_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTMP kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B066"/>
    <dbReference type="STRING" id="741276.A0A2S5B066"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="162" mass="18383" checksum="727869C423FF588C" modified="2018-07-18" version="1">MIDSYLSQKAELDDRAIHLLFSANRWERASQILQDLNEGRTVVCDRYAFSGIAFSVIKGLSWEWCRAPDIGLPAPDLVLFLRVSSAVAEQRGGFGQERYEKREVQLKVADAFRRLGESMPEGDWIEIDADRGMEEVQADIAARVEAVLRGSRVEEPVQQLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B090</accession>
    <name>A0A2S5B090_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B090"/>
    <dbReference type="STRING" id="741276.A0A2S5B090"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34004" checksum="24510BD5A0EAE4DA" modified="2018-07-18" version="1">MERRVSSAAATRPRTDENVYLFVPNLIACEEGDWQGINHDGGNAAPARPLGLAHDSSRAARLAPDHVGASPLTGRGRSELPGYTRVILGAAALTYMTTHPKFCTVAYCISALLDAVDGMAARALGQTSKFGAILDMVTDRCMTSCLLCFLASAYPRFALLFQFLISLDFSSHYIHMYASISSGSRSHKTVTKEQSWILWSYYNNSNTLFIFCAANELFFVALYVLANYDKPLLSSLTILPPAVVRFILTLPVPVIRAIEKVSWPLVVAAVTSPIMVGKQIINVVQFCKAAKMLTESDQEDRYAAQHAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0J9</accession>
    <name>A0A2S5B0J9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000123">
        <property type="protein sequence ID" value="POY70310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0J9"/>
    <dbReference type="STRING" id="741276.A0A2S5B0J9"/>
    <dbReference type="OrthoDB" id="15595at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018852">
        <property type="entry name" value="DUF2456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10445">
        <property type="entry name" value="DUF2456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="312" mass="35484" checksum="E7F7C39C67ACAD3F" modified="2018-07-18" version="1">MGRPRRPTVVREPSALRRPVEHECIEGTSRRIIWRNPFGLPAPLTWKQKLYILGPQMIGAAVIDGAANFGVACAMYRTISPGTTITMWDIRHNTVAGDCAVTVFIQGILTFVISSGLVHVDMRTNKIEAFPYPWPDTRFAVIPGQDPDPATQSWRKRLWWTFHQRHGLGRGLHFFSGSHINDVFNLSLGWKERAVRLFWSTWKGSVMSALYFLILWPITIAIIAPIWGGRDMAHTWAPEAIKLIFGFLLGLTQTPIVCMIAMGSEDSVRDHRREVHDRNIREMEEAPPAMNTEMERVVRPVSVHLRDGLSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0M0</accession>
    <name>A0A2S5B0M0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0M0"/>
    <dbReference type="STRING" id="741276.A0A2S5B0M0"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="22"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="376" mass="40229" checksum="D1BDE2CD4831E828" modified="2018-07-18" version="1">MTSPERAPSFRAWSHAKPPFPDTLSLLQQSPPRPADLKPHEILVQVVTAALNPVDVQLKNLPIFRLPALAYPKGLGCDFAGRVLGRGTAVKDLPIGAEVMGVTLSPLAGPNGGTLSEIAVIDTTRSTVIQKPPQLSWTQAAALPLVFLTAKTCLSPPYLLLPPSTEQRLAPGTPPTIVVLGGSSAVGQYVVQLAKKDLGANVIATCSGRNAEFVKELGADTVIDYTSEDVAARLRALRPKEGYLSVVDCVGGTDIVNLAPEILTPRTQAFPAGGSLTTIVGDKTSRTSMGGSILYLTTPSMLFRMFKGWAGYGFRYSCIMMGNHKEWLAAVGHLVGDGGLRVEIDSEYDFQDVERAYERLNTGRARGKIVVHVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0Q5</accession>
    <name>A0A2S5B0Q5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_6644</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0Q5"/>
    <dbReference type="STRING" id="741276.A0A2S5B0Q5"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="393"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="765"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY70364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="797" mass="87315" checksum="C5D71AE282DFA39F" modified="2018-07-18" version="1">MLRSLQGRLADPLPIGRALSTSAPLLRSAASAPPYRRAGPSASQGRAQTGHRTPYRGGGGRGGGQPWHQRQGGRRDPNSNNAGPSSISPAQLVNKLEHHLDTVWAKQGQASRELRQLGADIGVEPRRIAQLAVEFAQDAKDCLRDSRDHPTTSGIEWDLGAIRAAYISDGNDALFHATLATFLAWVRTNAPLPAPTAAKPIPDLALSKLHQLAAIADRRFAYEDFPDARQRRRRLILHVGPTNSGKTHSALVALARARTGAYAGPLRLLAHEVFSRFNEGKIGDEGKRTCNLVTGEEQRILDPDAGLQSCTVEMFPLSKRLDVGVVDEIQMIGDPQRGTAWTSAVIGSLCDELHLCGEESVVDLVQKIAAELGDECVVKRYQRLSPLVVSEQSLNSDLSRIRKGDCLVTFSRSNIFAFKRSIEEKTGLRVAVAYGGLPPEVREEQARAFNEGNYDVLVASDAVGMGLNLKIRRIVFESLHKWDGRQEIRLPTPQIKQIAGRAGRYGVHTPVSPSAPDLDPAEATAAEGVLGEATTLDAVDLPILQEAMKQPTVQVTQASLSAPFDSFKALFALLPPTTPLSRIFALSRAITRTKPHYRATGTVQLGEVGDKIAHVKPLTFFERYTFGLAPVNTRDALVVDTLIHFAGSYARGEKVVMEQWGHEMGIFELLDRVADAAAAQRQRSASTTPDWTPAPLTRRQSAVFTPQMLQSLESYHRCLTLYLWLSYRLSPIFCDQPAARELRSRVEKAIETALAGIRFERVDRSKGAKRNKARFSEASAEESSRTGDFLSMLEKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0T6</accession>
    <name>A0A2S5B0T6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0T6"/>
    <dbReference type="STRING" id="741276.A0A2S5B0T6"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="81"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="299"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="514"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="667" mass="74023" checksum="E35955C9C55467EE" modified="2018-07-18" version="1">MSDDASSDDDTAAAPAGQTDADKANAAAIKAFFTSHKNASTSSQKALSFSTLPNCTLSRQLLLALGSLNLSTPTPIQAECIPLAMMGKDIVASSATGSGKTVAFWVGVLERLLHRDRKNPMTRVVVMTPTRELAVQVHGVGMALARYTDVSFCLCVGGLSLKVQEAELKQRPDIVVSTPGRLIDHVRNTPCFTMDGVEVLVLDEADRMLEEGFRDELEEIISAAPRSRQTLLFSATVTESIQQLTRLSMNKPVRVKIDEMGAAAKGLEQECQSSVCLLRVRGDKAGESIELNSRSGERHREALLIALCTRSFATGRTIIFFRSKAQAHRMKILFTLFGQGLERSDELHGDLTQEQRLRALKRFREGEIGFLLATDLASRGLDIKGIENVINYEMPKSIEIYLHRVGRTARAGRKGRALTLVGESDRKLVKLAMKHAPPESIKQRTIPSDVVAAVFKEMRELEPEVKAVVMEEREEKEFRRGNMELQKASNMLEYADEIKSRPARTWFQSQSDKLEAKKVGKDEHNSKFSQKAKKRTFQEEEEPISKPPKRTPFSGLSRREKRRKMAAWEDEEDRQSGAQRELAASIRSAKKASRPDKLQAVRPERPSGFEAGNRKKQKKGKGTAFDREMGVAASAGEGKRPGKRERESAKGGAKHKLGRMGPKVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1C2</accession>
    <name>A0A2S5B1C2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine cyclodeaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1C2"/>
    <dbReference type="STRING" id="741276.A0A2S5B1C2"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="34861" checksum="30AF6F5AA07F66E0" modified="2018-07-18" version="1">MAKTLGAISAARDSEAAGPAAVQNPLRISTESRSHKTLYMPSRLATAETADTAIKVVAVPTPDCTLSGLPGTTLLMNESTGAVRALVNSAELTGLRTAAASALATRTLAQPDSRSLVIFGSGVQAYFHARLILELFPSLEHVDFIVRSRNERTSSLCAKLSQRFDSVTVQVREAGEVDDVLPRADIVCTCVPSTSPLFDVGMLKGTVHINAIGSYTPRMFEFPPELVSEAEAACIPQILVDSRSACLAEAGELIAARVAPERTTELGELFDPVSGRLREDEKATKAMADLRRAGKSLFKCVGIGGMDVAITRLVVDVAEKQGTGSIVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1H3</accession>
    <name>A0A2S5B1H3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000113">
        <property type="protein sequence ID" value="POY70627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1H3"/>
    <dbReference type="STRING" id="741276.A0A2S5B1H3"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="365" mass="39917" checksum="C95EF9FFC9C77D3C" modified="2018-07-18" version="1">MNDRPSHPLLDRLEAKHSPPSLKETSLVMLRLHWPAVRDVGDAPFSLLKSLLPHSAADQLAEIEDNSPHIAPHTNGAERCADSGDSTMRESYELTFSAPWRPTGIWRELCVHEFIEVRKAVEDGRISKKEEPKSWREQYSLEEVKREEKMQAIVSKLRGKNDEYKYGRATTKEVDWRVEKKRRSNAASYTARPKTLMEKARHNSKAIKSMYAPRRRSTKPPAPAPCSQPSQRAVSLLPSAAGLLPPARLSAPGLASPKKRVAITTEPAPAATGLATTTTKKRSIPDSPPAGVASVKRAKTVLSPPPPRSRASPAQPPPPPSPAPIPPSPSRAQLFKPYAPGAVPSAAAAGPPKPVPRGIFMPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1S1</accession>
    <name>A0A2S5B1S1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1S1"/>
    <dbReference type="STRING" id="741276.A0A2S5B1S1"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="124" mass="13329" checksum="AAA5859C10044893" modified="2018-07-18" version="1">MSVPSSKASDVAQNPYFRRDTRRNYPKTEVVTQPELAKLLIAQGGFEALPPISAAEGTQSTAVTADSPAPSLASLYSTNTSVATTSFRPPKPPGHKYAWKPSAEQAPSDPNAYFPMVLYDTARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1U3</accession>
    <name>A0A2S5B1U3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1U3"/>
    <dbReference type="STRING" id="741276.A0A2S5B1U3"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="178" mass="20055" checksum="9678D3BCA0167366" modified="2018-07-18" version="1">MSSSSFELVAITPENSVHTIPETLRLIKALALFERDPDAVVANEELLKKAFFGDDKAGGRTYAEGVLVYENGQKPEDDGAKAIAMAVWYYTFSTWTGRGGMYLEDLFVEDPHRGKGIAKKLFQHLGKICAERELPRLEWVVINWNEEAIKVYDKMGALTMSEWDLRRLEGGALRKLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Y0</accession>
    <name>A0A2S5B1Y0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Y0"/>
    <dbReference type="STRING" id="741276.A0A2S5B1Y0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="54918" checksum="27ED5D21C3C723C9" modified="2018-07-18" version="1">MSDMHAIVPSLDALASSAGLVLGVVVLTCYFLHPLAGIPGPLRAQSGLGGWQTVRAAKRDFGWKLAELHDRHGAFVRIGRNSVSVVDPAAKVTSPSLLATLDHDEHNLARRGVSPAFSMNLLLDLEEFVDSAFDDFIATSGKSRATIDLGTMLQFLAMDVVGELAFGQGFGLSKAGRDTGDYLPMLDAYTASACLSGTQPWARPILHRWLTRKLGSSGAAALGAKASVAVSRRLAELDKAAQAGDDSNLRKDVLSKLMSAKNPDGSPFSIAQVKVQANSILGAGSDTTSITFRALLAYIVRDPAVYNKVMQELEGAAEEGIVSLPLSYAAAQKLDYFQACLKETLRLHPAVPWVLPRIIPPGGASVACHHFAAGVEVAMSPYVFPRRKEAYGDDAEMFRPERWLEATAEEKKRFDRNLLTFGQGNRICVGKNIALMELSKLAPSVLYRYNLAFTPRRQAGSPHTLPGRAIDGRLDDKEPWHCESQWFSHQKDFWVDVSIRSGSQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B235</accession>
    <name>A0A2S5B235_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_6243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B235"/>
    <dbReference type="STRING" id="741276.A0A2S5B235"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11369">
        <property type="entry name" value="RNase_PH_RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000017">
        <property type="entry name" value="Exosome complex component Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033196">
        <property type="entry name" value="Rrp43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="59"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY70830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="310" mass="33101" checksum="29C9CC36558A1A84" modified="2018-07-18" version="1">MAATETSTAPPTSTSLTPALFKRLFPRPYLDRFLDESVRPDGRPIQATGAQAESSDVWRDVSVNIGSVSTAPSSALFRLGKTSVVCGITLEIAPPDLARPNEGFIVPNVDLSALCSPLFRPGPPPDEAQVLSSRLRNILLASNVLPLSNLVIEPGKAAWVVYLDIVCLNYDGGVLDAAVLAAVGALRNLKFPQAEYDPDTGRTQCRRVSEQYPGTRISAAREPVCVTFGVYNGTLLPDPDLFESQLCATEITVVLGPSAAPSSSSSSSPLSKAPLLNVYQAGAPLEDPRKVVKQCIAMARRRAEQLRESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B264</accession>
    <name>A0A2S5B264_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B264"/>
    <dbReference type="STRING" id="741276.A0A2S5B264"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="329" mass="35804" checksum="8D41FD701EDD6058" modified="2018-07-18" version="1">MIPTTFGFHSTSDEVAQHYASQIKGKVVLVTGVSPNGLGAEAATAISQQEPKLLILAGRAREKIEQTQAEINKVAPSVETKVLILDLASLAKARQAGEEVESWGLAIDVLINNAGVMALPDRQLTEDGFEVQVASNHLGPFVFTNTILPSLRRASAPRIVNVSSWGHHLSPVIFDDVNAEKNYSKWERYGQSKTANILFAVALSKRGVCAVSLHPGAIRTELLRHLTREDELAMGFINEDGSQGSRFAFKSLKEGAATHIVAAFEPDLQGQGGVYLDDCQIQKEVEDYATDTASLPELYLTTLSLTRTSAQDNAERLWKVSEEMVGQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2A2</accession>
    <name>A0A2S5B2A2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1682-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2A2"/>
    <dbReference type="STRING" id="741276.A0A2S5B2A2"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49009" checksum="C461DB67B3C2FAE0" modified="2018-07-18" version="1">MDRRSAMYAPGTAIACLAMAGSAQAAWGFNKETPLKAGTPVDAADPVPAAAPQPVDPLYPEVVASPGQPAGVAIPSSRPPYTGTDYSLGPIHFRPAEYRMEGVMLAFLAAYLASTFLIRQANRARASKWFSANEAVLREEFAGVGLGGGTLFKGDGGDEFVSYATGRRGCEYVWTKLRTGAQDAVGVAYHLFRGIIDYKYEAGTNKVVLDFKLAAPKGTPGAKMVFAVVRRDLLRRTCDARWDLRTFTNVSETPGVSPSLIVMTESGDVTNALLKDVETGLMEAFKDNSDQLEYFESLIISDMPAQEPSEEKPTLPEDEYRMQLRLRLPSASRAGATAPWITLACNVADVLHSKQKLVPDVAISKAKKRRADALELLMKPLREEEAERAAEAKQNELALKRKLELDRREAAWAKLSPAERIKAQKKEEERERKSQMKKQAKRQQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2N1</accession>
    <name>A0A2S5B2N1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2N1"/>
    <dbReference type="STRING" id="741276.A0A2S5B2N1"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16031">
        <property type="entry name" value="G6S_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="543" mass="61694" checksum="27BED5E1AB6539FD" modified="2018-07-18" version="1">MPAAIPTRPNILFVMADDHAAKAISCYGAEINSTPNLDRLAHEGMRFDHCYVTNSICTTPSRATTLTGTHNHVNNVTTLDSKIAKDLPNVAKHLRSNGYQTAMIGKWHLGEGKAHEPTGFDTWDILPGQGAYFDPLFINEAGVHREMGYATNIITDKTIDFIKARDPSRPFFAMCHHKAPHRSWECDPKHRHLYKDPVRLPETFSDDYKNRAQAAAVAKMRVESDMSYNDLGLAQPEGGSEVGDLELPAFPFISSRKVPMPDDVTKLRLVDRETGENFTFKTRDELSRFKYQRYMQRYLRCIQSVDDNMGRLLDYLEEAGLAENTIVIYTSDQGFFLGEHGWFDKRFIYEESFQMPFLCRWPAVVKPGTVCTDIVSNVDFAPTWLEAAALRVPTYMQGDSFLSSLQGLPRPADDDSVAYHRYWMHNDSIHNAYAHYGIRDQRYKVIYWYNEGFGLPGTGDGGQEREWELFDCREDPLELFNVWSDARYAEVREMMVKRLNDKMAEIGDNPVHKLGVSASELDAIDRAFAGSNIALKAGQSNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Y1</accession>
    <name>A0A2S5B2Y1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Y1"/>
    <dbReference type="OrthoDB" id="2803071at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39698" checksum="7A061A624D2E20A1" modified="2018-07-18" version="1">MARLPGVSPEDTRFDEELRAGATAQPLAAGQTLSPRGPCIWPEAVVSAHPAAQRASDGSQRDRRAVIASLAEAASSRAGWQSLSFRLLRQLSGGEDCFAQVWLVEASVEGQVAGRVVLKLLVEELFPRDSIFIFRRDRTAQESADAEAMAERLVASYERLQNLQGASVPICYGSFSFTIPSGTISCGIVLEDLTGNATVSEYLSSHRPELNSVQKLDSFARTLLGLVHTFHALGVATVCWSETDIVLLRESTPQQPLFVVFDFGDATTVEEISQKWPDDHICRWPYADEHSAYMELEIGLGYVAKQWYLAAYDRDPTWLADFASHENTLRVRAEDGYVFTAGSDDDDEEEDSDNSDGRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2Z0</accession>
    <name>A0A2S5B2Z0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative NADH:ubiquinone reductase (H(+)-translocating), or putative NADH dehydrogenase</fullName>
            <ecNumber evidence="10">1.6.5.3</ecNumber>
            <ecNumber evidence="10">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="10"/>
    <dbReference type="EC" id="1.6.99.3" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2Z0"/>
    <dbReference type="STRING" id="741276.A0A2S5B2Z0"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="277" mass="30020" checksum="4ECFD8FDF8772776" modified="2018-07-18" version="1">MPIGSPEIVFAARDDSNIAAAPAHTPAHSPQQDPLVNRMMQNVARAVARQARGFASTARQGSDALMVHRNSSYNSPDIPFKLSAENQKVAETIIAKYPPQYKKAAVIPLLEVAQKQNKGWTSISVMNHVAEVLEMPPMRVYEVASFYTMEPVGDHFVQICTTTPCMLGGCGSDKIVDAITSHLGVGLGETTPDKKFTLLEVECLGACSNAPMVQINDEFYEDLTPESIVKVLDDLAAGKKAKTGPQSKRKGSEPDGPLTALNNLPKDAKAQFAEEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B303</accession>
    <name>A0A2S5B303_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_5474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B303"/>
    <dbReference type="STRING" id="741276.A0A2S5B303"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY71164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="486" mass="53324" checksum="78FD8235ABD183F0" modified="2018-07-18" version="1">MAAIPRRTSAVPAFFVNSVIENYAAKSSTPISLKHMINFGNAGRNKGEKEEADKLLKGGNFLRTELPTRLSHRLRDLQELPLGVASHPRIAHVYNMYLEAFEQIRKFPVISDLDDNDRFCQFMRETLDKHRVVIPELAIGIAEASPHQLPPAALDRIMLRMLRSRISRRVITEQHLALTEQFRERQRKGKGRADAAFPGREDETRVGIVDTKMNAADVVLKCAELIKALGGPESQVPIVIEGATERTFAYISEHLEFMLFELIKNAAHATVSAHGAEAASRYPTIVTIVHRPRDLELRVSDQGGGIPPYGGLPPDPDDLSSNPLLSPVALAAPLSAQRLDIFSFSHMRRYYQHHAALASTARPADSTSSSLDAQPKTPSPPTIPLVEPAQSSSTASTSTAPPRGIAALHDVNELAGTVQEQLERRRQLGNVGEGERELIDAQMRSGIGLPLSKMYAEYFSGSLDIYTVQGHGSDAFLSIPKFGIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B399</accession>
    <name>A0A2S5B399_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B399"/>
    <dbReference type="OrthoDB" id="10471015at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="380" mass="39992" checksum="E506B47E53ADA86E" modified="2018-07-18" version="1">MFWVGLPDERPSIVSDCCHLRSPMSPSPSKPTARRRPFAVLPLDQFLSRSSPRKRSTVTIPLQLQDMSLLPSPFPSSSTATASARPLATLYEAPTSSRTRRASRDASLGLVSSPRARAMVDEDDTDAISTTNDALGGDDEPDALGLHSSPRRLFDAFVAASRANPTDNPAALRKKTSTSSLSAAHFIAERSHMPPPASPRATGSPRTRLARPREPSPPNWSFYQDEEDESAVGIPLASESAASAPSPVATEESDDAMPVDKENTAPSPRRARSASIHPITSPPASGPATAPETAREIAPTLPHTPPRPASPSLPLFSPAIIGVVDAPHFADSGATSFFAAAGTGSTSFATTEVTASLLPEVGIARKKRRGDEAGHGIPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3E3</accession>
    <name>A0A2S5B3E3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase delta/zeta catalytic subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3E3"/>
    <dbReference type="STRING" id="741276.A0A2S5B3E3"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="3">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="990" mass="108778" checksum="D45EC854890E7230" modified="2018-07-18" version="1">MTEASDPPAPTDAAPSAQTVPPDDCFIRFRLSAIDFVPSVAHSQFDNRRSPFVKGDMYTVPVIRIFGATDRGCAHTTTVSDYIRRFGAALNKAMGIALPSKHKKGQPTQYVAYIVLCKGIPFYGYHVGYVPYLKVYLVHPRHKTRLSEVLRSGAVMGTPFDVFEAHVPFLLQFMLDANLFGCGWVEVGKALFREDLPDHVPSPSDEYNQPSCTGPYAFRTYTTRTVPPDRVHPPVEQGGPAKTSYMRLELDLPVSAILNRRRLTPRNLHHNFIELLHPDRVERGKNVRSVRELWEDEQRRRSARGETGPFEIVDNEPREWDERPPGAPVWKREPEFRAKVKVQIDDDLAKYRDRVGPKGKPKPDFATYVDEKGRLIEGAQSFWLDRIRTSFEQVDAVYVERFREDEIKNYPFGAWAVRGFGLNVTEAQEATWLHAGHPDDVDVDHLHASQAAGKSVRLKRRPQDRVGGSDDEDEPMDADSDPDDVEQDGRNQRRGPGPPATQAEALAQARRRADVAQMRGREASVEEGEWEREPDEVRDEDDDGFWGMGAGTDRPVSPALGEDDEEDRDTTTISPASRRSSVHPASVSPTKPTASAKRRANGDAAPPAYSPAKRIKLEDPLAAIEALARQNGSFGQQAASFLPRASIKSTTASPPGTPPGPELVHPLQRGGRQQSRGSTSVIGPQAKQSPRARPARNPFSSPAKAVSVRMARPAPSPVSTTAHLFDTNKPLSSEVSFEQPPAGRQLHSSPSKALIDYSSPHMRSSAPPIEHFLQSSPSSDEGKDLVSPPPSPSPAPPLAPVKRARVSMTASQIEAEFADLPEGALDDDYHPTPTVTEEGPSQLPLHMRTDAAGPAAPGDAHSERMTRAVALPEVESDQALSPKSETRSPAAEARASSTPSLLPGDIDAMAPARSTDARPTSPMIRRVKFASSSREAIPEPRAANAASRADGSIENSSGEIAGEEMLTFRHSTRAHQLIRFYTQPKKREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3G9</accession>
    <name>A0A2S5B3G9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3G9"/>
    <dbReference type="OrthoDB" id="2524742at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="189" mass="20798" checksum="067BF34C32729417" modified="2018-07-18" version="1">MIASTSSRLGEQPACAFSSPLGAIHHASPEAQGASLRAVMSLFRRNRPAKADQVLPKAGSRFPSSPSARQAGLACTLERSTTFTVAYEASPLPAIDETEVEHRLAHSSPPPTYEAATGVVNGVEEDISIDDNGLVFIKTVGQMAMRVEMRVESPSERKHRERQERLERKRQRLIEEDLRLCETLDKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3P3</accession>
    <name>A0A2S5B3P3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_5711</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3 12"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3P3"/>
    <dbReference type="STRING" id="741276.A0A2S5B3P3"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="375"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY71399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="444" mass="48489" checksum="A35044938A3014EB" modified="2018-07-18" version="1">MADAPEGTLPVPPTTAAQLTAAEKYQLVTQNLAEVLGGDQLKAILDERDLIAYWGTAPTGRPHLGYFVPLAKLADFLTASVEVKVLLADVHAFLDNLKAPIELVEARVDYYRRLITAVFRSLNLPLDKVKFVVGSSYQYTANYNLDKYKLTSITSEHDARKAGAEVVKQVSSPLLSGLLYPLLQALDEEYLGVDFQFGGVDQRKIFTYAEQYLPKIGYTKRSHLMNLMVPGLSGGKMSSSDPNSKIDFLDPPAVVKSKIQKAVCAPGEVEGNGVLAFIRHVVVPLGELFRGQGRASVRAWVGEGAPADAVFTVEGNPKFGGETHHFRSVDELEDAYAQNAVHPGDLKSACIAAINALLAPIQAEFNGSAEFQEAERRAYPPEVKPAAKKKEKKYTPKPEHLMTPEEKARQAEKDAAFAAKKQPKQGGLNETEQLREAVVDTLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4F2</accession>
    <name>A0A2S5B4F2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4F2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4F2"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="236" mass="26440" checksum="C92DC669491E1710" modified="2018-07-18" version="1" fragment="single">PNTILRPTITGWTSVQHPRRGDRYREHAPLAFLIVDHSQRNLWGAHEPLNVIISAKSSADVLKESGFISYSRSLGLWNECANLHLGDPQVANLGDGKGWERELFVMRESVWPFPWVGSCLETITGGNHFRAYKQNGTEADSGAWFLAASKEVDLRGKHKIAHNGYNIGRDLIVERASSGSTYLNRRYETKVEWLEGLLRPGSEGMAHGIAQDGRIALLTVHEYFIFSTPPTFIVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4G2</accession>
    <name>A0A2S5B4G2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000076">
        <property type="protein sequence ID" value="POY71601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4G2"/>
    <dbReference type="STRING" id="741276.A0A2S5B4G2"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="391" mass="42837" checksum="A5705BF22436EEFD" modified="2018-07-18" version="1">MASTSRTTADLSSTFAHQQCVVHPLVLLSIQDHFHRVAKNTRKRVVGILLGQDLTERGQGYNISNSFAVPFEEDERDPRTWFLDHDYVEAMNDMFKKVNAREKLIGWYHTGPKLRASDLEINDVIKRYTPKPVMVIVDIRPDHEREAATGGNAGGIPTDAYFAVEEIKDDGTSSQKTFVHVPSVIEAEEAEEIGVEHLLRDVKNLSVGTLSSRVSDQLSSLRGLGTRLVEIKEYLEEVVAGRLPVNHQIVYNLQDVFNLLPNLDAAARSSSSVTDSSSVAGDVNGTTTAGSGSKRPFTVATNDQLLVMYLSSLIRAVIALHDLVLNKQTAAHVDSDPSDSHDDATSSTTTGAPTDAKADGDQKKKDGKDQGEEKSDAQKAKDWFKGDEQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4H7</accession>
    <name>A0A2S5B4H7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4H7"/>
    <dbReference type="STRING" id="741276.A0A2S5B4H7"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="654"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="7">
        <location>
            <begin position="718"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="867"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="991" mass="107537" checksum="EC5F4678122BD2EC" modified="2018-07-18" version="1">MSFQSEHPTRPPDHTRQVGELDDPQVCLASSSGTRSESLHRDPNAQTAAIDSLMHESSDDARMSEPAGNPTDSLDPRHVASGSGDDSTEAPIARSRFATPTSRTFNTPRNHADRQVHPHPSPPLSSTLNIPPSPPRPRMRRVPRQSPNARNERPAPSTLAASGFAAANLGAAPVATTSRSLRRRSSMPTVAARRTRASSLDAAPTTASRRAGARAAANRVGGSPSGSGPAHRDPDEHWLSEDEAVDTARSANRIRQPLRRRRGSGDEDDDGGDSEDGGRKLVNPLDLGLDTRARRQLHHRPAKHFNIAPVAEPVEMLSGPKLAELVPQLAKILTCPACRHLLRDPATLVCGHSRCLYCSPTPAASALSQHLAATGSSRPIAGVSEQPSAVRTPFEQPPQVVAQAVLGTPQPLPSPGVAQRLDAGMLYRTLSSSSIASTPSVASAAASVATDASNHRAHAAIACADPDCKYNFSHLVVPHRPLRIDYTLRKLVDILRRAVFGIDEYVAAVEANASKARNGEVLTPLFTSIRLGSEAPGELTSGLVSTRTDSSPEPATGSAAAPAPLKRDDSGSSGGGEDEPIAADDAKRARKTTGAWRSSKKSRPGFDEPDTAMSPPDASTPAHAGASTSSMTELPRLSLISPSLVADLQTECECQVCFQLFHEPVASPCGHSFCRNCLARSYDHSDKCPLCRADLAPLAYFRWQRSSVDLTSVIQVALPTLAAERLAAVEEEEKALLAQVPIFICTSAWPGIKCFLHIFEPRYRLMIRRALETPDRSFGMLLPVRNAAQPDAVNEYGTMLRITSCQMLEDGRLILETVGTYRFRLLERTMVDGYTVGRVERIDDVSPEQEAELEAAALAQNDSPEFQEMWSQPDDPARAPTIGGERPSRPPMTGNMELSTDQLMEICLDFIRTLRGQSAPWILERLNRTVGEMPTNPHDFTWFAAEVFPVEDHVKVVLLQITSVRERLRLIVFWIEQFRSSWWYTRGCNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4M2</accession>
    <name>A0A2S5B4M2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4M2"/>
    <dbReference type="OrthoDB" id="2529474at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="451" mass="47765" checksum="F2EB621BE49825E5" modified="2018-07-18" version="1">MSSTTRAGRRTQPRQSAPASRTLACRICAKRRVRCDGMSPCEACLRHAAWKGWPAPTQCDYEPGVTPIPNPAVRPGAAAGSTSANAHASGSKHSHDGDSEDGATNGGAEVASSFGKHPGKPLQKGLACISCKSRRVRCDGGKPACSSCVKTAKWKHEDVNCVYRADLYVQRCREAEEQQRRGVTEADFKHENSDDSLHAPEDMADQPDDFGFHEEPVSARATPTCQYPSGIPTVLPAVLPPLPALPPLPALPILRSQGPKQDDDAVMSLDQAVLAASTSSSDSVSFRAVHFPPAFFPASRASSQSGFTTNPPSPAITHTETDLSSWPSPRSPLDEWCAHNVPTYPPVPYPPATELEGIDPAWMAALNAGTIPPLSLSDTLESLGLGGNGPAVTQAGFVMSGVTAPLDDPQAIDHNFGATALKTENGFGIDATLTLPMETPWRSGAARPDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Z0</accession>
    <name>A0A2S5B4Z0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5187</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Z0"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Z0"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="191"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="395"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="792"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="726"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="840"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="736"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="868" mass="96991" checksum="745559EE23F4630B" modified="2018-07-18" version="1">MASAQSVSSGNTNQSTESVITAIVTGLIVAGAEVAAFVLLKDRIRQIYKPRTYRVPTERRVEPLSHSFLGWIPQLLRTPARSILERNGLDAYVFVRFLFLMLEIFFPFWVVTWIILLPVDAAKSGGGQTGVSMFTFGNVGPAHQNRYAAHLILAWLLTFWVLYLVKREFSHFIVLRQEFLMSEQHRRLPQSKTVLVTGVPKEYLDREAMYRFCRPVPGGAKRVWFARDLKDLPDIFDRRAKAVSKLESAETKLLKLATKQVAKDQKKNRSPPEDSDPEAHKAAIMRYVPQKKRPTHKLGKFGLYGKKVDSIDWAREEIVKTTQELETERGLLGGDKYPYDSAVFIEFHSQMAAHMFAQCLNHHAPLRMSSRYLEVGVEDVIFSNLSMNPYQQRIRSFISWGLTLGLILTWTAPVAFVGAISNVSYLCSTVSWMRWLCELPVPVNGIIQGALPPIALAVLFMLVPIIMRLLARFEGIPLRTQVELSLTVRYFIFMVIDGFLIITLSSGLIAAIPEITQNPGSAPLLLARQLPNAATFFLTYFVTASFAGAAGALLQIAHLAVYYVKLVLLGSTPRAVWNIKSWFPAVAWGTLWPSMTLLTVIGLVYSIIAPLICGFACVAFALFWFAYKYLFLYVIETAPETETGGLHYPKALTHIFVGLYIEQVCLAALFFLAQNSAGKQSAIPEGALMVVLIVITAIFQLILRSGYKPLITYLPLSIADQIGESEHVPASGAGSDPRRSMQVESGRQEKDVSRETARTHTDGHEMLRAKESRGRETDISTAGSYHGAHGSHEYDEDLDRAFDHPATYQGYDTVWLPEDPHGFYRDEVEATRSAGVNVSSDNAVMNEKGKVDVSRAPPGEDWDASQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5F9</accession>
    <name>A0A2S5B5F9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial PGP phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000062">
        <property type="protein sequence ID" value="POY72019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5F9"/>
    <dbReference type="STRING" id="741276.A0A2S5B5F9"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="58084" checksum="5C76E634EBE4C039" modified="2018-07-18" version="1">MANWSGIAATLSALVRPSTLRPSLVVPSIAHLDWLQLRSHAHIDAVVIDKDNCIARPNDDTLASDDGLCAAWDELLRVFGPERVLVVSNSAGDLRKDPLLIQAETVSRNLSVPVLVHASPKPAYDCAKQIAAHFLPPSASSSSASWTETSQPGTSVVFSPLAKARARQARTKRAIAAPEGATATTGTSRPFRVLVIGDRLATDMILSSRLSSLSLPLTVPAPVLPSDRTASSGSSASASPTGSLSRLVARLRPTPRLTVGRAGQRIEAIGVLTTRLWGREGAGTTLMRFGEKAAVRGLEWRMERARRTRRRAVTGVLARQEEEEVEWRRYTFGWEAEQQRAATEAPPKPPALATTRDLPAAPVTRRASARSLGEALSTIPARISTATSSLLTLPYRIPNLASSFLHSLPQRVHDLTTRVFLAFLRMLERRGPGAVRVLEGGLQRLVDIYRPPNEGVTSTALVSKRSRDGNDDLPRFEVVERAVDRLEQRWDEAGRTLDRLRGRVGEVTGRAAEQAEAVRRRLAPPKAETGPSGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5G1</accession>
    <name>A0A2S5B5G1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5G1"/>
    <dbReference type="STRING" id="741276.A0A2S5B5G1"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="218" mass="24405" checksum="00F615E5804D13D1" modified="2018-07-18" version="1">MINGNTSMAWRHYGCITAKQFENLKNDFEEADDVDGFEDLTPDDQEKFRKAFQQGHVDDEDIPDSARKQPEVDSDGNEIVQEPKKGKAKAKGKSKGKKAAEDGSAEEEAGEEAKPKKTAQKKKPVKSKAKKEESDAEESEEEEPKPKKKAPTKKRAAKKQADSDEEVESEEEQKPKKKAPTKKRAAKKQADSDNDVGSEEEVQTLCLEMMSCSPYQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5K7</accession>
    <name>A0A2S5B5K7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin interacting protein 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5K7"/>
    <dbReference type="STRING" id="741276.A0A2S5B5K7"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="3">
        <location>
            <begin position="714"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="832"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="883"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1212" mass="128052" checksum="85B30A66A5046613" modified="2018-07-18" version="1">MASGPINATGSSPVTTLSSRAGSHRSAHSGPASTSHLESTITRLLVATKQLLEGLARWSRREVDESVISDIYVKLGNDFNTACAAFAKEGITMNELLSVPADLRVCLETCLSDQPSQATLERHLPQVRQIIIGLLHGLREKQRLYREGVAARRQREAGRAVQPPQQTSVQQQQQQQQYQAAGSGTLTPTSASRSRDDLRRFVTQAQQQTVPASAAMVGPGPIASTSTSTNDSRRYVGDSGATSAAARRSTSDQGLPGQPSSVGADPRYSKTMSSRSSGSTLASTAGSISAMRSTSLRDSSRSMSNRPALEDAFGPIQSPPPPPLPPTSSQQIAPSSQSRGSVASSNSGNRLTRSASSSSLDTHSIPAPTSTSTNGGPVRPTLERSATTSSRVMTSPPPPPRRRGEADVPALPPTPTIDTFGPVVTASSSSSNGSVPSSSVTNPFARPPSAASMRSMHDDPTSGAQAASLEALRADNLSRRASKRYSAYAIQKMTSPGSGGGTSPAGGTGGAGGAGAGSGGGGMSPSQSASPFMGQDDGPRSALGVSSSAGRELAGVDTPRRSKSEYFAGSTGSSRHHGGSGHRSTSSHSRRPDVPPLPPIPRSYTVGGVVPASPIAEEEHERSIDSISSPALSAGPPSVPPPPVPAEQDTPTTLPAVPQRSASSSSVSQPADSYSPRPVSPSVQLSRQPSLPNEVAASVASYTASEPEYPCSVFLQVGRNVKKAQLASAPQVASLRQLFVERFSYNPGLGEWPEIYLRDADSGVHYQLEEMSEIRAGSVLSLNVDTVEQVKTHIDHGLASLAQEMKELRATVTAMRPPSIVATNALLSPSHRDSVMSLSGTSPKMRPSPSERDFQQAAKRVLHSQAPSRVTSTIEVDAKDSAVADAGEAGATETTRQAGEPEASTRGTTTETSGSVTPIPPATAMAPIVETLKSQHADVQSLRQEIAVLRQVYADWQTRTKAMFASVRVQTSHVQHLAKTKLSTNRAFVEAGTARLDTESEALVVTSNELNDTLETLRDDLLRGVKPRPQVLTETATALRQATETREKLSAWLKEVKPVWSQTWSEELAKVIGEQKAVEQQQTLVDDLGDDFAQAASTFAKIDAISKTLKPTARAAKVRERELGGVENAQEGLSTVLLEVKALSPDPTRRLEAIQRAEQQRQAELASRTDEFAEELGEFVGQKRLKKSGGIEETERVRQARSEATLRNMFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5M8</accession>
    <name>A0A2S5B5M8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4885</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000059">
        <property type="protein sequence ID" value="POY72078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5M8"/>
    <dbReference type="STRING" id="741276.A0A2S5B5M8"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="10">
        <location>
            <begin position="34"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="770" mass="85122" checksum="3EE2594A27542924" modified="2018-07-18" version="1">MPYRPATVTETSVIEGHEYPVGTTFAGQENLPRLPIPPLEETMKRYVKALEGLQSPEEHEQTKGVVDGFLKNEGPELHERLKEYAANRASYIEEWWTESYLSHQESVVLSLNPFFILEDDPTPARGNQLMRATSLILASLAFVHDLRTAQLEPDNFRGIPLDMSQYPKLFGTSRIPTREGCRMQIDPESKHVVVMARGQFYWFDVLDSKNRPALTERALLANLTAIQNDAARTPPNQVAQQALGVLSTERRSTWANLRQGLMKHEGNALCLDVVDKALFVVCLDDTTPASASDMCNNMLCGTYKLEQGVQVGTCTNRWYDKLQIIVAQNGAAGICFEHSAVDGHTVLRYVADVYTELILRFARSIKSGAGTLFKARLSPWATGGPGKKTAIEGEEPETVDTEPKKLEWNMTHDLKMAVRYAETRLSDLICQNEVVALDFEAYGKNAITQHGFSPDAYVQMAYQAAYYSLYGKVESTYEPAMTKAFLHGRTEAIRSVTPEAVNFVKTLASDASARQKVDALRKACKTHTALTKECSAGLGHDRILYAMYCLAQQRQKAQRQRSASNSNGVMSDSDGEDSDGLHGIAGTELSAKLAAQIPDLFKDPGYAQLGHSTLSTSNCGDPSLAYFGFGPVVSDGLGIGYIIKGDSISFCVSSKHRQTQRFLNALESYLLEMQGLLKQLHQEANRKPNSMFVDHFAGEIDAQTGKPIRQEYKRSGTRTPLEYSDGYGFYGSLSQDVEKALHEKGATGQDGVAKPKPQIRPGARIAKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5Z5</accession>
    <name>A0A2S5B5Z5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5Z5"/>
    <dbReference type="STRING" id="741276.A0A2S5B5Z5"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="456" mass="47875" checksum="8F51BB6526BEA50F" modified="2018-07-18" version="1">MASKGEQYKQQGNAAFLKGQLALALASYTTAIQLDPSVAAYPLNRAAVYLKQSEWVRAEKDATTALELDGGNNVKALYRRATARRHTGKLELAQQDLEQAKSQGGGADVDKELAIVLELRGTAKSGTNGGTTQPVNGKEGEAAPSQQNGNSRLSSDRLRAALAEPSSAAAPPSSSSTSTAGLMNAVSTRRLKPTAASAATSPIANDSKSAANGGVNSFAAKKEARLAKHRPVIAVAESGSRQETALVSKPNVTAADQPSPAAAPPVASTSTRPQSLSPTRPPRSVLVATPPSAAASTLLYHTAATSFPTALEAHFLAHPQRGDPVRLAAVRELAQRYPASAARRSPRALTEDSKLSKEPSTLRDWMGPAGLTPDLLSELLAEVDALYPPASASTRASIGDHEGDLDWVVELLEALPTCQRWDSASLFLATDEKKAVMRVLDRAKARLDRISTSWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6F8</accession>
    <name>A0A2S5B6F8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6F8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6F8"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="949" mass="103648" checksum="1D55109698182F37" modified="2018-07-18" version="1">MTEQTRSRKRRKADQDAVELFDRVVDSCRRVIDLFDRPYELNIARDGLAKLSEFVSQLDAALQRSESADTVLLTTESKDQLDSLGTALWNKALGLKPLTKRDDTSASVLAAARTTAFQLICLGSVDPNSETARLQQLSLGTKCATALLDAAQPARAETLVTDLGTVANALANVDSLPNDAARKRIKCLLDFYCCRIRLTSARGLTPIAYWLRDKAKALLAHPSITKREIEKLALAAYETGMTLLRSSPSREPAQSSEKSLTQCNEASLEWLQLALELLERQGDGATLTLQVEVLKALAHALLTATPPRSRWQQAEEVLRQALARPTALRSGELAPRDGTLSRRLLKLVVARGGNVDEITVAFLSAASCPGTSAEGAYGLVATLELLPEQRPQGKLRVLCKLCEALATSQTDAERALLSQLVAAAFLQAADADCALLGQCLDRVLELLPHFRIQPAEAFASATCLWRFGEKAEKDRSFRSAADWYLLGTQDCFSELDPGTRTKLARKAIFSLVEAGDRPAAKLLLDSAIVQENLAKNHFLRFYALEREPAPSLEALDALLHAPDVQPDLLLWTHKIAVERGDQALAKRILRAIGTHVLDDATGGGASAQIDPLVLVRSLIRVLSADLKTETRDRTSLAEQVHEQLSIGTSTYNICAEHCHEWDTALAKAMFGVTAEIMSFLLDRGQLLDAETAQKLALCRLAYLVALTEEARACGDNAKRIHLFDAVLTTACNLLRSLASPPFALSAGVADVQGAALAVQVEALVETSKWTDLAELASTFETDASRSLSALKILVARAADRRSDCPHDVLSQILQRALAVLYARRDLDQTRLALWLRSIVSALLHRRALPEARKYVENAIHFLSQPESDYPPDEAEWMAATAWDEGVDCYAASAPAEGRQWCDLGIRVATVTNSLLAQQWHSELAQLEERFGQSQGEETDAHMADSTGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6V5</accession>
    <name>A0A2S5B6V5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="3">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_4323</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6V5"/>
    <dbReference type="STRING" id="741276.A0A2S5B6V5"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015577441" description="non-chaperonin molecular chaperone ATPase" evidence="13">
        <location>
            <begin position="33"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="592"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY72497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="663" mass="72390" checksum="383B1814BE952D99" modified="2018-07-18" version="1">MAPRPFQPTRAAFAALFLALVALLVSFAPVNAQKEDYGTVIGIDLGTTYSCVGLQRNGRVEIIANDQGNRITPSYVGFVASSGERLIGDAAKNQAPSNPTNTIFDAKRLIGRRFDDKEVQRDLKHYPFKVKAGSMQQPVVEVKVADKAKTFTAEEVSAMILGKMKETAETYLGHKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRVVNEPTAAAIAYGLDKTGGERNIIVYDLGGGTFDVSLLSIDDGVFEVLATAGDTHLGGEDFDNRVIEHFTKVWKRKHDGQDITKNLRTMGKLKREVEKAKRTLSSQMSTKIEIESFFEGEDFSETLTRAKFEELNLDLFRKTMKPVEQVLKDANFKKEQVDDIVLVGGSTRIPKVQELLREYFNGKEPTKGINPDEAVAYGAAVQGGILSGEEGLGDVVLIDVCPLTLGIETTGGVFTKLIPRNTVIPTKKSQIFSTAADNQPTVMIQVFEGERAMTKDNNHLGRFELTGIPPAPRGVPQIEVTFEIDASGIMKVSAADKGTGKSQSITIENEKGRLSPEEIERMVADAERFSEEDELVKKKIESRNAHESFIYSLKAQLSDQEGLGGKLESSDKKQIEDEIKKAQEWVDDNGATASAEDFDEQREALQAAVAPITAKIYSSGGAGGDDFSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7B5</accession>
    <name>A0A2S5B7B5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF962 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7B5"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23046" checksum="24C593CD58C95D22" modified="2018-07-18" version="1">MARHRLLDLEQQFTFYASYHTNQVNVLIHIFCVPTILFTALILTHGIPGASKSLATIPFDLFGQHYDVDLTFPFLWAAGNAAYFVLLEPVAGALYAPILLTLGHLSNVLYSSHHDEAMRIASYAFVASWIAQFVGHGKFEGRAPALLDSLLQSLVLAVFFVWLEVLFFLGYRPQLFKRLQAKTGVAVAQYRKERAAKAKASGAGNKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7C6</accession>
    <name>A0A2S5B7C6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7C6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7C6"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="166"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="6">
        <location>
            <begin position="444"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="4">
        <location>
            <begin position="636"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="872" mass="98320" checksum="201603C775A0B47F" modified="2018-07-18" version="1">MVLRSSSWQQDDRANRSRSPVQYSPKVSYKDHAGRNSGPRRRRRLPVAFLLAATVCFLAVWRYIGGFPSDKTLSGRPYAPISAQTSSWRDAFAFKSSARRKRGDLAVATRLQTSKHPFRLPEELLPVHHEAKRMLYHNGPLARTRPPPNQFLRDPHADLSQPVVGIITATNNPRPVMRETAASLFAQSLQNFVWVIVNDHSTEAASAAILADLGKDPRVHVITNADRQGLAEGRNIGFEWLFAHFDPAPRFLVSLDDDDLFEFTALEKACWTLESNPTWDLAGFRYIKWGAANETVMTGLHSHDANFKVGNFVPNAAVYTSRAVQSSGCRYNEKEFHRGGEDWDFWMCLAEHGHWGGSVLEPLYWYRMNPTSFRASRWGKTFENGFESLKSHVQRRHPSLADKFPSKVPLRSVQLEPVTWTPPFEQAIAHTDKQIMFVAAWLYVGGADIGLMHMVELYARAGYRVTVVCTLNKVPEGIELRPWIMQYTHDVHILPSIVRAHDMPRYLVNLIRTRGIHEVIFSNSQLVYEMLPALVEQVPHIKWIDSFKTDTQKSQYLHNEAYDGWKSGGYPRYSIMTQRFLARTITCSNYLKDWLLERGHLNADRIGVVKLGIEASHFAPATPSHRNAMKESVLGVEPNTIVITFVGRLDPQKRPLLVPKIADELLRRIPDADFIIVMLGDGDHLRKLKASVASLELEEIVRVEGMQQDPSEYYAASDIFFLPSVSEGISIAVAEAMAMGLPIVTARAGALPEQLGVLPTKTRTAPNELGGILVSHTLDDEKDAILYAEALEKLMLDPKLRSRLGHNARKLVKDSFDWRTTLSGLFQETEIAENLPGHGATLPGYPHPAAELAIQTLLFEMSRETDQIGYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7E3</accession>
    <name>A0A2S5B7E3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Haloacid dehalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7E3"/>
    <dbReference type="STRING" id="741276.A0A2S5B7E3"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28757" checksum="5CF6C58A1D20F092" modified="2018-07-18" version="1">MAPESRPRIRAVLMDQFGTLTDQHGSMTRQLEQCGAASDLGGVDWSVFAERWRAGYLRRTREIAAGASGPSDVDELHLELLDKLLEEKEYDKVAEQWSPDKRRQICQFWHKLDAWPDTKPGLDAVRQLEPPVLLATLSNGTLRLLVDIARHNNLPIDAHFSGDLLQSYKPNPRMYCRAAELLGFDAAARQRGEVAMFASHIDDLLAAKEQGLYTIYIRRPTEDTSERRDSVKTFADGGEVDVIIESMAELAEHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7G9</accession>
    <name>A0A2S5B7G9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7G9"/>
    <dbReference type="STRING" id="741276.A0A2S5B7G9"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="137"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="237"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="36950" checksum="8DC034E2AC2AEED7" modified="2018-07-18" version="1">MATQQLATPPTLPAVQLSTAACIAVTVSNPMEVTKTRLQLDGELQGKVHLKPAVAGAGGVAIPDVHASSKAGPNGKVYNGTFDCFRKTWKSEGLGGVQRGLGAAYAYQFVLNGSRLGFYEPFRNTLNSLAGNDPTTVRAWSSVAAGASSGVVGAVLGNPLFLVKARMQAYSPFNPVGAQHHYTSALHGLVDIVRKEGPRGLARGVDAAMLRTAMGSSVQLPAYNLGKTTFASWGVGDHAGLYLLSSIFSGLCVCTVMQPADTVLTRMYNQSPNSIGPDGKPRGLLYKNPVHCLFLTWKTEGFFGLYRGTLSHLLRIAPHTVVTLVANEFISRQWTQYKRRKATAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7P6</accession>
    <name>A0A2S5B7P6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7P6"/>
    <dbReference type="STRING" id="741276.A0A2S5B7P6"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="361" mass="37723" checksum="C3916A5D3AB63117" modified="2018-07-18" version="1">MAAFVRGVPSLVAHAHPTVPLPAFRAAFAAAHPSPRLFSSSTRSAIRHQVQHSHHQQPASVFDALRASFHKSAATGQKRGIATGQGAYGSSSGAYGQQAGGMDWGKVGVNVGLGIAGAAGLHLLLNGETKPLEAHEWAYLRSTMKWTGAGLAITAGTAFAAFRNGVTYRLMAMNPWAVAGISLVGGIGSMMGVMYTAPDTPAHYACWAAFSAMQGLTLSPLFFIAPHILGRAGLYTLGATAGISYVGSTAKSDQYLWIGGPLLAGLGVLICTSLAPLVLPATTSLRTLSMLESVGAYGGVAIFSGMILYDTNKIRRHANLSSRGAIPADPVRESVSLILDIINLFTSIVRVLLLQQGSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7Q9</accession>
    <name>A0A2S5B7Q9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7Q9"/>
    <dbReference type="STRING" id="741276.A0A2S5B7Q9"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="261" mass="27698" checksum="8C52F1E973AE48FD" modified="2018-07-18" version="1">MASTLPTHNGGGYEKSAAFHDVEHGGAGRQISNGDSFEGAPFTRAVTPGGHLLDTSQPAFPVHHRRFANPAPLGLCGFALTTFMLSLINLGTRGVTVPLIVAAPALWYGGLCQILAGMWEFASGNTFAATAFTSYGAFWISYAFIILPWTDIGSSYANEKEFTNGVAFFLWGWFIFTFIMFVASLRSSIALAAVFGSVDLTFLMLALAELGDVGNPAHFQKAGGAFGLCAAALAWYVAAANLLTPDTSYFILPVGDVSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7T7</accession>
    <name>A0A2S5B7T7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7T7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7T7"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="81921" checksum="CB93CCFEEC8B5124" modified="2018-07-18" version="1">MKKIFGGSRRSKTPAVPHGGEGDANGYGVLHSTTGSHGSDLPPSLGGGMSSPHLVTPTPIYAAQSPQHSILTQSALTYPAAGVFTAGTSAAHAQSPTLGLAERTLSPPPAHGSFSQPGYAPISDSSHGTVLSGGGVGGGQPDVVSEMDPPANLAELEGKLSVGIDFGTTFSGVAYGSSRYMGGSVRQILNWPGSYETYRKVPTAIVYYQATPADEAIVVAWGIEAKAMTVRPGFYKVEWFKLFLDPAVLREGRLASSARLPDLPPGKEPIDVITDYLSCLWLYAKERITEEIGSVADLEAADVILTVPSAWDAAGCQLMRNAAINAGLVQSARGGDRSWRERLRIITRVEPEAAAIHASMLSSLFKLKASQTFIICDAGGGTVDTAVYKLIGQLSQLEIAEMCARSGANCGSLFLDLRFEALVKSLLRDHPVHLDNPSLIAFRHSFADCDKLMYRGEADDDTGFRFNCFNIEDAHDPEVGLERGELVIPGSVLRRDVFDPVVDEVLTLIQHQLAKLPSGRVDALILVGGFASSSYLCNRVQAAFGNLIPIIARPTDADVATLQGAARYGLGLIGGKGTVSSVISPRSYIMKCKLPATDEDQYQRPGFISANDAGVEVCANRLSYLVAKGGRSLRCMDFIAPNPVDELRPIAVLRKGQRLKSRYCKFSRAPSDCVFTAVLYVSDSDKVYRYTDEGPIEELCRWTVDLSPLPAFQQNAQVAREGGAGGGNQGFYTEFALALVLDSAEVIGVLLTDEGEEVGRATFEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7T9</accession>
    <name>A0A2S5B7T9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7T9"/>
    <dbReference type="STRING" id="741276.A0A2S5B7T9"/>
    <dbReference type="OrthoDB" id="3363286at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="325" mass="35502" checksum="9873FFECC523A05A" modified="2018-07-18" version="1">MPYQLASSQLTALRSLHAQSGFCRRLSADMMVRFELTRPQTGTRSLLLEPSRILHPRFDPSVAGQGGHSTGKGMWVTCWSEAVETLARKGSYKRLHSSASMSDPALVCAKVHSQLARRVVQEAELLAERVKSWPNGSKGGPISTWGDVPLRVLPHESDIANLEREKERRIVAILDLSPSTPAADPESPAKEPAADLDGFSSGIPPAPPPPPIYRLSSFFQSAVLPPESLASFRPSPSDPTSSVEQQLLTATRAPLEGMLALLARRFEREDPSRATSGPPSEGSDVFVLVAPRDPRTEAERTRARVVVPLAVALWRLKLWTGEGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7V5</accession>
    <name>A0A2S5B7V5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000046">
        <property type="protein sequence ID" value="POY72858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7V5"/>
    <dbReference type="STRING" id="741276.A0A2S5B7V5"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="491" mass="55567" checksum="5F047A11093BD40C" modified="2018-07-18" version="1">MRDHEESGRPPMGRAQGPHEHALVPPHWTHQGSSSPFSPKEQYERDTSEVNQTGSRKRRRRAPLIPPTRAEYLDPENPQQRYRWTTRAHRKGVPPQLVRVRQDGEDVDSGWTGSVRREKSWWKAVRRVRWWGWDLRDISWWVAFLFTLGSVFWCIQGIQVFCFPSRTTTVFTNAETAMAFLGGTLFWIGAYLGYVEALNPAFADWDGAFGYEVGELKRTVTDEKKSEGRPVATQDDVPQEHALGKRRHHFGRHAPPPPLESSTRSRNDRIDSQTPAPISAAASRSSDSDEATLAPVAAHPKSASSKHAAPTARSNDVYQRTQHPRWKWFGLPPPGKRLELGFVANAVQLVGATSFQVSVICGLPGVLAASGSTGGVAQQGYVESTWIGAYWATQVFGSPAFIFAGWIFSLETQTKWWKPNLMSIGWWIGLWNFIGGWGFEFSGIFGIWRQTDLHDPEKFQYWGTAFSTFWGSWAFLIGSYIQMLETLNKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7W4</accession>
    <name>A0A2S5B7W4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_4034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7W4"/>
    <dbReference type="STRING" id="741276.A0A2S5B7W4"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="256"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY72874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="747" mass="80984" checksum="D796E5474D506A84" modified="2018-07-18" version="1">MATPAQTPGATSSSSTFGLAHKSRGSFLAAWGRVLLVLCISGSLGCACVWPVLAAGSLLPVVSVVSLPALLATSFALFHFLPATLRLALAEPQPRLLPPFHLFHPRQNFRIWVSFTCILLDLHRSRLLTHFLEDLTKKVLLLRKTGSVPTCRANIVFVPADLDTGQPARRLDVYLTEENDATGEDKENVPLAQVIILLAFPSYRLAGSRGFPASAIAAQLRSTLDVCVVVPSLTPFTRDAPEGEALERMVGETRECVKWVGENIARYGGDSEQIWLMGFGAGAHIASLAMVQSAVVAAREGYFAQRADHETTRVNKEGLVSVDDGSSSSVLDALSPRHSGAAPSSNAPVIGGEEGMRAGGAHAADSPFSPSRRRQRSTSSDLARKSPSTSFERSSSTVEDIQEGDDDEVERLLRQSRLARLEKLEAEALPAWSEPPNDVEPSIASGAAALVSSGGRSFDMTARETDFDKDDDLGEPDSELSISDGIKSCRLFTLDSILSTRLAAQEHARSSGLRAPEEEQDLFVPDPSLYRHEPEFGFDSRQVCSSLATFDMPSIRSERKKPQREQSKRVEVKGMILVEGTYDIVKQGKWDADRGVDQVSSLMRLCDAPHRDFLHACPSHLLYAASPLLSAPDLASQGIESCHEIGVPVSRRLLPTKVLLIHGGADLLSPFSPAILFRNLLIGVGLESDDVKVKLYRHLTGFGALSALMGHGSYVSILYDEIAEILELDEEGTEDEQECVEAARQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B836</accession>
    <name>A0A2S5B836_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B836"/>
    <dbReference type="STRING" id="741276.A0A2S5B836"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="109"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="514" mass="55613" checksum="C85B6D8361CDD1AA" modified="2018-07-18" version="1">MPSADIPRMKGNGHTSNGHPPRDSPFPGPSETRPSLLPKLVLKPWVTPTPAGIVLTNAQVVDPAGGKLLDGLQSIVIRDGKVAAVYPVDEPDLLAEEGSLRRVDLGGRYVSPGLIDGHVHVTAVPGTHNLKEMTELQPEAISYRTTFVLREMLMRGFTTVRDTGGATKPLADAIEEGLLVGPRLFQCGKAISQTGGHGDFTPAKSGGEPGCCGGHSVLLGRTADGVPQVLKATREELKAGADCEGFLSCCLVIKIMVGGGVASATDAIETVQYSPEELRAITSTCWQMGRIHTTAHAYTPEAIRHAIDNGVKGIEHGNLIDRETARYMAEKGIYLTPTLSCYGESGRALFTVDLWRIMQRAPWENFLPPSGQVKNKQVMEKGLEALKLADEEGVTVCYGSDLLTSMHALQTEEFTIRSEVLPSPTILRHATTNVARMLGMQGKIGVLAPGAFADLLILDANPLEDITILDRPEDHLHLVMKEGRVAFSTMPQLQTKEEEEKQEMLRHKKLRPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Q6</accession>
    <name>A0A2S5B8Q6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Q6"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Q6"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="120"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="750" mass="79391" checksum="F1067DEE0E0C64DA" modified="2018-07-18" version="1">MNDTSPSTLFDYYPRSDSTAAPRASGSNLLPVSPRRPAHSLALAPHAYSVLNPRSEPFMQPFAVPSYLRHARLFSDRFATAPSDPTSTKVGAAQTLHTAGQATATDYKGKFKQATTLPPSATATSSATSPVVRDPILLPTCWNKDDACALLELTSDALGASFAGSAKNGDRDAAAVRANRPVPNQAGVYYFEVKILDKGVSGYIGIGLCQRSVSMSRLPGWEDKSYGYHADDGRAFCCQGTGEPFGPVFTTGDIIGCGIDWTDAGPPRGPRERTGVKSSARDRERERSAAGSGAADKDKDKDKAGGGGRVFFTKNGQFIDYAFCNLQGTLYPTIGLRTPNEAVRANFGAEPFAFDIESLVLVSIRSHHAQERKRAVLARLATLPPPSYIASPSHFLPSPVAASTPPIPALLPPSDRERLHETIQSLVSGYLHHHGFGGTAERFEKQLKEERRERAIGLIPSTATDSAATAQGDSNRSTEPTDTSSGGNEAAQLATYRAEVRSALLSGTAAGAERALRLIESHFPAVLASDSATTTTTTTTTTLSTAAGVNKVGANDAVEVVFRLKCRVFVEAAQEWSRANRDPAGMEHSTTTAGGKISHVEPIAAPEGDEDTAMMSSSVVAGDPPSAPSPSASSPLTLDSLLSLGQSLHAEYGSDPRPRVREELQAVLGLMAYRDPEKEATGRTAELLAKSERENLVDQVNRAVMRASGLPPVPALEALFRHATASIQLAAELGSGGAAMIDLRAQVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Y6</accession>
    <name>A0A2S5B8Y6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BMF94_3569</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Y6"/>
    <dbReference type="STRING" id="741276.A0A2S5B8Y6"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="POY73236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="483" mass="52314" checksum="C6F4CEE62414571C" modified="2018-07-18" version="1">MAYPQYDYGSALPSGRQQYTTLDDDSRYPASSAQNPFASQTSFHQGGAVPEYPPAHQAMYSAPHANDSTWSLEEDRSPFGDNAKEGAAGIQRGRDNPYAQDYKQKGAWKKWTFIGLLVLLIVGGVAGGIAAWRVTSSNKNNSSGSTSPGSNSGKLQYIDGTAKAVKWNPNDPSEFQLDSRLKPIFYGLAYTPFNALEPWCGATLNNVTQDIILMSQMTTRLRMYGSACNQTQLVLQAIQDTKVNMTVWLGAYVGDNSTVNEQQQQYVLDALQIYGTDHVSGVIIGNEYVLNAVNKATAVATLVSLISAFRPKLAALNLPKTLPVGTADAGSTYSQTAGNTLAAGSDFIMANVHPWFGGVPVDQGAGWTWDFFTQNDVAVSEEVSNKPIPYIAETGWPTASMTPANATLGGAVAGVSELQTFLNTFPCQANANDTYYFYFEPFDEPWKVQFGGVEPYWGLFGSDRQLKDITFPTCQVDSSHASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B965</accession>
    <name>A0A2S5B965_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3641</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B965"/>
    <dbReference type="STRING" id="741276.A0A2S5B965"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="545" mass="59683" checksum="EF47243EE2276283" modified="2018-07-18" version="1">MTSWSGRRFWRLYALLAVLRVIVAFTSTSVIHPDEHFQNPEISADVTFNYGAAAQNAAMLRTWEWLGPAPVRSVVPLLLSTGPAFSLLKSIAGPHLLVYAVTRHDQQALLLLATSPISFTFLLRPFSNSLETLCLALILPAAAKARRGSGDVVWLTSCGAIAAAGCFVRVTFVACAAPALLYAVLTGNFGETFRPFGRALHRTALVAAGGIATALLCILADERFFLGSSATSFFHRLPLITPINLLRYNLSSDNLLEHGLHPRYLHLLVNLPMLFGAGMVAIFSATKQWLFARVARRDSDRSFDETALLLATILVPTLALSVQPHQEPRFLVPLVVPVTALAARAPFLRDRSPKGRRRRRLFWGAWLSQAALFTVLFAYLHQGGLLPVLFALNRELSSPKTVVSPVGTADLVFWRTFMPPRHLLLPLGPSTSPKPVIRVTDLAGTQYAELARTLTALSTSRTSLVNGQVILVAPEYASELAGLDCSDFVEAQQSTKQPFCLEPFWPDRRTFGVHLDMDRLDQVVASKGGVGLGVWTVKSRIEGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B971</accession>
    <name>A0A2S5B971_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B971"/>
    <dbReference type="STRING" id="741276.A0A2S5B971"/>
    <dbReference type="OrthoDB" id="5428737at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="778" mass="84216" checksum="C9DC8B281B2D2506" modified="2018-07-18" version="1">MPFFQPPLRLDEFPRASSAYPVASTSTLPTRDADSPSPNKKRRVGSLPPALAAQQRKGATSSSRATSQSPAPRSQAAARKSISDAARRNEINSRYAELTRDEARLQATLRLQDAWEDIQRRHSKLAQTGTGDTTSGATRRRYRHRPGRTRALPVEEDDIIDLSCLDFVQDRGVLRGSKAGGFAIGRYGNSRDGEVLVGLDTGGEGTGGTEEGGNGTADEEDDDDEEEEWQDYTDSDAPTYSSDDELDDDDDLLPPPSLLFREQRRKEAERLREMREFQEQEANARGALARAQQDDVIVVGGGNVQLPAPIGPPSSAPRGRLVSLAHRVVVSDDEDEDDLALSPCRAQSMAPSRRTPVRRGKAFSQPPSSTATLRRSVSELHFDSPPAHLTSGPSPSPQRVTPVKSSPRPRQSPAPVKEVGLRSPPSSFSSTRLPPSRRDSFSRPVSSTLSRESLTSYAYHARRSQPVSASPLREVISVASPTPPPALPVRRPRQRSPSPELYCPAPPRAATVKPSQTSPPVPVQQATPTPTPPPAPKVPTPVWRSTVSALKSRPRRSHSFELIIDVKPLRTRQTPGPPSRARPAPVAARQIVSSISMPDLPTRPKAGGYLPEAAEDLTQATRRVNGLSTPPLSKRSTAPAPARRSISSSPPKPAPAPPSSISRSRFTATPSVILPAPPKLPPMRSARRAASEDDSEEDELMLSSPTKPSPYRRGPSVRPSMTPAPPRASSAWPRGRSRSVSVTTTNRPPDSGISWRKTKTIAPSAVEDSDSEDELGQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9B5</accession>
    <name>A0A2S5B9B5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9B5"/>
    <dbReference type="STRING" id="741276.A0A2S5B9B5"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="125"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="205" mass="22883" checksum="85A7FCE2D789D8CD" modified="2018-07-18" version="1">MSSSSSPSAPPRRPALPFSAATTASQTAGPTPTAAGIDDSLARDFPEVAQLSKDELQLLVDDAAYFDAYFHSTPQALNYHAQLEQKLKDNIHLAQESEAMKPALNALRDETARLFHEANDLKQQAAYLTEAQLDAYRRFSQPAQLARYRAATTTQDHLSDSLVAAFLNGQGDDESFVKQYREVRKLFHKREIGLQKWDEGKVVWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9F7</accession>
    <name>A0A2S5B9F7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MTHFR SAM-binding regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9F7"/>
    <dbReference type="STRING" id="741276.A0A2S5B9F7"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="316"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="614" mass="69567" checksum="30234356519AE93A" modified="2018-07-18" version="1">MVKISDKIRKAEREGRPWWSFEFFPPKTSEGWVNLYDRIERMTQLGPIFVDITWGAGGSTSEATTNFVKTAHSDLGLETCMHLTCTNMPVEMVDKALKEAYDSGCRNILALRGDPPRGVKEWKPTEGGFNHAIDLVRHIRKHYGDYFCIGVRLILELLWSRRVAGFPEGHPDSESQDAEIRHFKQKVDAGADIVFTQMFYDADVFIDWGRRLRAAGITIPIVPGIMPIQTFSAFKRRTDFAGTIVPQELWDLLEPIKDDDAKVREAGTQYVADMCRKILAADLGIHGIHCYTMNLSRGTEMLLEEMQFVPTADRVKPLPWRVSLTQKRRTETTRPIFWSNRQRSYLVRTRDWDEFPNGRWGDASSPAFGDVDALLAALPIKPQDAIDLWGKPVTLGDVAALFARFCRGELKRLPWSDQPAAKETSRIAEQLAKVNELGFLTINSQPRVDGAKSEDPAFGWGPINGYVYQKVWVAYLEFFCPPQHVEELLEILNDNPSITYHAVNKQGDFRSNTVPGPNAVTWGVFPGAEVIQPTVVDSAAFQAWKDEAYELGSQWAQLYQETSPETQKLIHNVFDDYHLVNIVYNDYRDSDEDAVFKPFFELAGKKGLAAVNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9G9</accession>
    <name>A0A2S5B9G9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9G9"/>
    <dbReference type="STRING" id="741276.A0A2S5B9G9"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF7">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="121"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="318" mass="31993" checksum="33CBC8CB0F017B3C" modified="2018-07-18" version="1">MSFLDKFKATATRVGTQATAFGQTVAREAQTGSQKALTSFKLENECEKSAKILASFLADPRHPESALNAIPKEVLARAKGLAIFTVLKAGFVWSGKAGSGVVIARLADGTWSAPSCIATGGVGFGLQIGADLSEFVVVLNSEEAISAFAKGGNLTIGGSLAAAAGPIGVGGAVNTAILNPAPMFTYSKSKGLYAGVSLEGTVLVERKDANEAFYGQSIPAVSLLSGKVPPPEAVGRHRNASALYETIEAAESIDESGLPDSAYVVPEGTVGGSAPLHKSTSATSATSATGSTGAAAGHSGPVAPVGQSQQLFDATGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAB1</accession>
    <name>A0A2S5BAB1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAB1"/>
    <dbReference type="STRING" id="741276.A0A2S5BAB1"/>
    <dbReference type="OrthoDB" id="2534600at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="727" mass="79505" checksum="8F64DD9ABC45EA73" modified="2018-07-18" version="1">MALNELLPHSVPSQDDAATTPIHTKKPGLKTVVRRSCAACKARRVKCERPGDDDEVDCVGCVKRGWQCLPAEIKPRAKQRNGKRVKAIQEMLDEGRSISSESPEAISTMALTVNAPRLSEQAVNVRLGNIELRESVMSSLLESFFTFRTISTFSNEVDFHVTFNRAGRRIDQLTDVNQILCGTLLAIGARCSDHPAILGPGALRIDELTEATKNDVDLTQYGRARETAYRKLAQQALTLADEKGLFRQRSPESIAALMFLEGLNVTDRPVDPIFAKTCANQLRDLLISAYSQPDVLGAVQNTTLAWTAVLRDALASAYNGSTFSFSDDDLWLLRGEEDPPPSLEEQLTSPLHADAEVNYWTLMSSLVQHIIELCRETPTRLTGVRARKNPTLDEEFAHGYLERCIIGHAACAELRRRAKLVRGTQKFVRDAETLARTLSFSAINCTYILKDVVDRRLDARPAGILCETDASLSPEDLSDYWHRLVKLQRDIQVVFFSCARETVALIKAVLEAGIPLGTHEWLDPRSIAVLFTRASLWAGAIVSAQTREEGGMSDYTIDDKLEDLRWIAKALRSVGWSSAKHAACLPWIEQTIADVEGQRAWFYPGGPAALPDNDFVLPDPPRIDSADLSFGEAPSSFGPVPHATASPATSSTQSASGLTTPFGFEHPGSDPSMDAHAFLASLGTAFPPSPATHVPATDGTDWTVPISEEALLAALNLPPSTDAFPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAG5</accession>
    <name>A0A2S5BAG5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_3310</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A2S5BAG5"/>
    <dbReference type="STRING" id="741276.A0A2S5BAG5"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="13">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="12">
        <location>
            <begin position="228"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="350"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="692"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="696"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY73770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="79421" checksum="6974E7378D249C92" modified="2018-07-18" version="1">MAEDYGKLKVAQLKDILKERELPVSGVKADLIARLEEHDAASGQPTPTAAEAEAVAQGGANDAAAAPSESVPAGDSGEAAPATLAVKRAVEDDEAAEHVKRMRVDEEAAAAVPPANPIDSALPPAHSEAANEVPKVGDEADVTPAVIAESKVPAEALTAAAAAAPEEMNGAGNPKERLTDDDVSIAEADEPKREQADFVDTGAKVEEEEEEEEPPVYDFEPEEEGGRPADLYLDTINRSALDFDFERLCSVTLSHNNIYACLVDGKYFQGRGKTSPAYAHALNEDHHVFINLETQKVFVLPDGYEVNDASLADIQYLLKPTFDPPLLKRIDRSLAPAFDLAQKPYYPGFVGLNNMKFNSYMNAVVQLVLHVPPLRDYFILSPLPSSSSTSELVRRFAMLARKVWNPRQFKAQVSPHEFLQEVANASHGRFKITEHGDPIDFLSWLLNQLHRDLGGSKRPRSSIIYSTFQGEVRVDDQQIIKTGEFGTKPRFDVDREIKSSKTPFLFLALDLPPPPLYRDAVESNIIPQVPISQVLAKYDGETTREDPTSGLLRRWKITRLPPFLVVYYKRFTSNRFLEEKNPTIVNYPLRGVDMRDYVDGSQPISAYYDLTTNLALTTTTTTGVTSTSAEWKAHVHLRPPRDPKTGELADGIKEEDDKWFEMQDLVVREIEKGLVPLGETYIQIWERRTPTGSWDDMVKVDPPRPKKDPAKAGKSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAJ1</accession>
    <name>A0A2S5BAJ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAJ1"/>
    <dbReference type="STRING" id="741276.A0A2S5BAJ1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="24"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="552" mass="59921" checksum="3B0089EBD804451F" modified="2018-07-18" version="1">MVQLQGTADVTQIEAPVTFKAYMLCAFAAFGGIFFGYDSGYINGVLGSSEFIRAIEGPNAKAISSPHNSLIVSILSAGTFFGALLAGDIADRFGRRPTIIAGCFIYSAGVVIQMFAASALATIVVGRLVAGFGVGFVSAIIILYMSEICPKKVRGALVSGYQFCITIGLMLGSIVDNFTQKREDSGAYRIPIGIQFAWAIILATGLFFLPDSPRFYVKRGELDKARDTLVRLRGQPPTSHYIELELAEIVANAEYEARAIPTTGWFSSYAACFKGSLFDASSNLRRTILGTSMQMMQQWTGVNFVFYYSTPFLQSTGAVKNVFLTSMAFTIVNVGSTPISFYTIERFGRRPLLIWGAFGMLICQFIVAIVGVTKGFNHTHIDAAGATIANNISAVNTQVAFIAIYIFFFASTWGPGAWVLVGEIFPLPIRSRGVALSTASNWMWNTIIAVITPYMVGSNEGNLRSSVFFVWGGLCTCCFVYAYFLVPETKGLSLEQVDQMLSETNPRNSAKWRPTTTFAAEAGKVGGDARHLEDVKLGEVEGAEKAEVAHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBA4</accession>
    <name>A0A2S5BBA4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBA4"/>
    <dbReference type="STRING" id="741276.A0A2S5BBA4"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015430858" description="J domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="445"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="574" mass="61856" checksum="FC70822334DF1F29" modified="2018-07-18" version="1">MRTVALVVYTLTAALAACAAGLPDNAADLPLASLLSLAQDALSQGKSNDALQIYDHCLERDPTDFATLYKRATVRLASGHLARAKDGFRDALAVRDYDLAHLQLAKIHAKLAEYDDARGELDTFLRAAKKDRGKTDKDVVDAEQLRKDVVAAQKDVAAAKKARSSKPPRAEQCITASTSALQLSPQSLELRLLRAECAFLAHDFDSAIGDLSRAASLSPTLPQHLLVRIALLSSFFVPPANDRPEIPLDALQSLKRCLSADPDSKTCAKPLKQLKQLERDFAKLRNWIDAGKWMEVAVAIAGSSTKEGVLPRVKAMLETYQKPVAKTAKLDEVALPPTSASGAEGADGLAKFSPLLHSLQSTLCKAYIQLDSRKASAACAAALELDPEDTWGLVGRGDDLMKKEEWDEAVRVLSSAFEATGRSDRAVMEKLQKAQRLLKQSKSKDYYKILGVARDADAKTIKRAYRKGTLKAHPDKEGGSEEKMAQLNEAYEVLSNPELRARFDAGDDPNDPTSGQGSPFGHGGGSPFGAGGQPVFFQSGGSPFGGGGGFQQFFQQQGGGGQQFFGGQQQFRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBM6</accession>
    <name>A0A2S5BBM6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBM6"/>
    <dbReference type="STRING" id="741276.A0A2S5BBM6"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36789" checksum="7742738F63EBB5A9" modified="2018-07-18" version="1" fragment="single">MEGVTTQCELTSTSIDEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKCTRNLLGSLQSRDLAHSNHHLDPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKVNREKMTQIMFETFNAPAFFVQIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAIQRIDLAGRDLTDYLVKILMERGYSFSTSAEREVVRDIKEKLCYVALEFEQEMQTAAQSSALEKSYELPDGQVITIGNERFRAPEALFQPGLIGLEAAGIHETTYNSIMKCDLDIRKDLYGNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBW6</accession>
    <name>A0A2S5BBW6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2698</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BBW6"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="1136"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1319" mass="143502" checksum="ED0B0B085F8B47F3" modified="2018-07-18" version="1">MSSQKPGGTQSTLFSFFGKQGAAAPSTSSSSPAQRNAARPAPKPSSSSSKPAPKATGATKALTTSEADVLSLLSSDGPEVELEAANGDKGKSTIPAKRPAKEAPVASSSKSKLSAQVKDEAGSDEEDDNEDEQVARRKRPSLGRGVKGSRARVVDSEDSDGEFLRRHPREPSADSQVCTEEASSPVATRKTTNGKAPANGKAKKGKKKGGDDDDFSASSASGDESPDYFDDDLDDAIAEMSDDALMSDATSSSSVGAKPKSKGKGKAKASPASSTTKTPARQNSLAGFSAGATPGSRPMLKTASSGSGNIGNIKTAAEAAREKAKQDRQSNENVFSFLLDPKDADGNRPGEPGYDPRTLYIPKSAWATFTPFERQFWEIKQNHYDTVLFFQKGKFFELYEEDAAIGHRDFDLKLTDRVKMKMVGVPETSFDYWAAKFLAQGYKVGRVDQCETALGAEIRNKDDKKAGNKGKGSAKQANGKEIVRRELRSVLTGGTIVDGSMLTDDMSNHCVAIKEDTPSPTSPPSFGVCVLDASTAEFSLSFFVDDASRTELETLVRQLKPKELIHQKGNLSVSTLRLLRNCVGIDCQWTALKEGKEFLRAEDAKDEVIKLFKGDKGDEDEDAEMASKDTEGDSILPENIRQMLDKPVAMSALGGMVWYAGSDADAPQFALTFAARYRYLRQLNLDSDLVTARNFNVYDPLSRGNGTLVLDGQTLAHIEVLQNSQGGTEGTLLQLLSRCITPFGKRLFKVWLCAPLREVAAINDRLDAVDDLLEHSNFAIAFDGMAKKMPDLERMLSRIHGKTIKKSDFCAVIAAFERIVEGLKTLAEFSNGFKSEGIPALIESVPDISSLLEEIQEMYDTDGVSHLCCCTEAHLLTQRRILQTCDDAAEALEDARREAGKLLKCPQIEFKDIGTKDIFQFEVPKNVKVPNNWTKMSGTQKVSRYYTPETIRLIADLKEARERQQMAINDFQYKLYGEFDKHYATWMAVIKVVAQLDCLLSLSKSSAALGEPYVRPEVVEAKTAFADFEELRHPCIFSASTDFIPNDVAIGGEAKNLTLLTGPNMAGKSTLLRMTCTAVIMAQLGCYVPATKARISPIDAIYSRMGANDFIFANASTFKVEMDDCNKILQKSTPRSLVILDELGRGTSTYDGMAIAYAVLHRLATHTGCIGFFATHFTSLTEDYAYHPEIRLASMQTSVNDETREVVFLYKLIDGSAPKSYGPHVASMAGLSEAIVERAIGISKQFEESSRARELEMRANETLPLTAQADAAFLLKLAKLSLSGDAYKGDKAQLLRTLDTMRKGFSSLHELPNPPVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC26</accession>
    <name>A0A2S5BC26_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC26"/>
    <dbReference type="STRING" id="741276.A0A2S5BC26"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015697345" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="319"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="414" mass="42005" checksum="4DD241CF95FBCF26" modified="2018-07-18" version="1">MLSAALFASFAATAVLAAPVPAPVAVNATHNATAYYYYQNGRAGACGTQVADSAIVVGLPLEFYSNYNAPSPFCGDYVVVQGKNKNITARVNDASTLNSTMTFSIGAWDALNATATDLTTVQWRFANATEAAAAAAGVAQAPSSSVAVPSSTRSVEAQAPASSSTSSWTAPSSSAKAVQSSSSWVQSSSSSEWVAPSSSAKPSSIWTPSSSSTTSQWVAPSSSSTSQWVAPSSSSTSQWVAPSSSSTSQWVAPSSSSTSQWVAPSSSSTSQWVAPTTTTSQWVAPTTTTTAKAWTPTTTQAHAAQTQAASNANSGGYSGQATFYTQGGVAGSCGTVNSDSAYICAMNQAQMNSGWCGKQLQVTNTQTGKSITVTVADTCPGCSYGSLDLSTGAFGALGSYDQGVLPISWSVVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC32</accession>
    <name>A0A2S5BC32_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC32"/>
    <dbReference type="STRING" id="741276.A0A2S5BC32"/>
    <dbReference type="OrthoDB" id="2530128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="156" mass="16929" checksum="7460707F5492FB63" modified="2018-07-18" version="1">MPVGLQEARTGSAAILDLRTRLSVPPSWPDPLLCFDPAALPPLPEIKDHAIAQQVFLHRSIHMAEGDLSLLSRISKSYEPLEGLGDRILHLEDYTNYLTANRTLSFLSLAYGLPNRIIHTSGPDLALNQKVAADVFEASVGGVYDDAGSEGLKRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC62</accession>
    <name>A0A2S5BC62_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_2558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC62"/>
    <dbReference type="STRING" id="741276.A0A2S5BC62"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="735"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="262"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="935"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY74364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="966" mass="105434" checksum="9A06829C03313929" modified="2018-07-18" version="1">MNSQAGADPANRIVDRDGESSASVIDDSREASSGGADPSERTRSLASISDTTPGSSLGLTFDQGPTETVRAAVDAGLTSSSPAATDADVAFAAALSATDSQRTPKQAHFTLDPPETRTISPAPRRRPSYHQQRSFSTPPSTSTPTPPPPLTADPAPALSPPLPKPTLVQTYKDLHSLLKGFLLLVPPFIRNLRYLIPTPLRAAARFVIRYSAMFLHSRGILGSNWVYDVVASMWRVVIDIFFREIRSRGAWKIPRQNEGAVIFVVGPHHNQFLDPLLLMSEVRRESGRRISFLTAAKSMDRAFVGLAARLMQSIPVARAQDYAFAGKGTIQISLSDPLVVVGTGTQFTKDFEKSRSQMLLPRNLGSSTAEVIEVFSDTELRLKKEFPKKAVEDLKAKGQGVSFKVLPHVDQSNMYSAVYQKLTEGGSIGIFPEGGSHDRTDLLPLKAGVSIMALGAISAHPDLRLRIVPVGLSYFHPHKFRSRAVVEFGSPIEIPSEFVAEFEKGGDSKKKAIGDFMDLIVDGLKSVTIRAADFDTLMLIQAARRLYRPPGQNLTIGQVVELNKRFIVGYEVYKDDPRIKELERGVREYNKLLRYLGLKDHQVESAGRPRWRSFFILCYRLGLLTAWGTLALPGVVLNAPIFIAAKLISRKKAKEALAASTVKIAGRDVLATWKVLVALAGAPSLYTVYAVNAVVLAHKLGLPYRYKVLAPIATFAGLPAIGVAALKFGEVGMDVYKWVGMAVLLLVIVRVARSMRPLLLSLIPGKEPQLARLRHMREELSNELNELVDELAPSIFEDFQANRIVPSSVASPRRDSAQGKFLQHPLGWMDEFLFGYGWSNSMALPEERRMPRTGNESDFDGGFTDGQGTGSGYVSGYTTEEAPDYDEVIHILNREQGHPDSPVASASRPSLSRRNSRQRSRSQLNLAMMSPVNPTSSLPSASTSALPDSDGARKRGGGGGGASFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCP3</accession>
    <name>A0A2S5BCP3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCP3"/>
    <dbReference type="STRING" id="741276.A0A2S5BCP3"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="295"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="664" mass="73402" checksum="0987185B0DE5A5AD" modified="2018-07-18" version="1">MSSLLQHKTVGIRKPTRGHQPTATGQIRTDHELVDRLQQWKHVTKSLLHYYKGLVDIENATSRSTSALTETIQVPFHEGHVFSPDGWQAVLYDVRDTTKLLAERHSEFASTIERTVVRDLEQVRTNIKNQIHLVEKEASIVADEVEKERETSKRHLLELQNGIDTFENSATQMLPQKDPYLSHHLVENQLKKQVRKENDLQAAVIRFQQQQPAFEENVAKDIQAACKIYDEEREVQLREVEELQEKISEALQRVDPRAEWEFFASRTENSLIDPHAPQRSISAIQFPGQNHASTNPLKVGHLERKKRFSKKYTESFYVLTPSGYLHERRTSNQEDTTPPAFSLFLPECTLSAPAKESDRSHKFHVTGNKAVKSSAEAKMKNTLRFGGKELAYTFRCRTHAEMMGWWEVLDQLSRDTKTERETVTRVKQDPVGLAVAKVGYAEPTEETEHVAGAIAGVPGTEVEEVSREELEAEEAREQEGSAAARAGETTGEESRANTATTSIGGQNVVLGAPVVAAQQQHAEHEAHAEHEEDSEDGGGSSEEEYASDDEMAIARTAPTTPAPITGIAGARDPMEDHRDRHLKAETLPAYVGSGTGLPEKQALTTEAKGAPVLGNPVSNKSTVSGSSFTETLATSGNGAHEAERIETANNEAAPAALATTSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCW7</accession>
    <name>A0A2S5BCW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCW7"/>
    <dbReference type="STRING" id="741276.A0A2S5BCW7"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY74617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="444" mass="47522" checksum="C4E556C5184837D5" modified="2018-07-18" version="1">MGKRTSIGSASGAPAHRNSPNRPSAAAAGKKRSSLGTGAAAKPAPKLAAVAAAAAEIDSQDEDEESDDDDLLESGDEASDSEDDDDEGSDGDESEDVSPEALERMMKLLGDVDPKELGLLNGMTGEDEDEDEEGSDEEEEGSDEEEAGDSDEELEEGDSEMLPYEALEDADDEDIVPVEKTTTNDKVALERVLATIKADAGFFDTLTLVNPKPLNVPDADNDLERELEFYKQSLWAAMHAESLFEKASLPFHRPTDYFAEMVKTDAHMAKIRQGLLDEQAGMKASEDARKLRDAKKFGKKVQVERLKERQRDKKAVGDKLESLKKKRKGDSSFGGEDFEVALEDALASSGSASKKRKPNESERPGRAKRGLSRDSRDKKYGFGGGATGGRRGKQNNDREDGGGERGFGGPAGGRGRGGTRGGRGGGRGGSRGGAAKRPGKSRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD47</accession>
    <name>A0A2S5BD47_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD47"/>
    <dbReference type="STRING" id="741276.A0A2S5BD47"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="63"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="108"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="64807" checksum="C9DE35FF44B4E20C" modified="2018-07-18" version="1">MLSDWAELKSKRRAKETSAQRTAADPSTETASPTTVDDVVPLAESPSPDTPSLPLWEPADLPGTISIEQLAGRGRGLFARTPIKGGTTLLATKPLVSVLDSRNLPHRCSHCFRSVDELEVKVVQAKPKLLQCSLCHTLQYCSPSCQKVDWAVHKKECVAIRSAIKQSKAHGAVRLPDAPLRALGRLLWTAQANAEVWRQVETLESHRAQLTAEEQEKFFQLSVSLSAYVGQETLVPSCPNAASVIDLCSRFVSNSFALTCPTDLSNIGVSISPLTAMINHSCAPNAVVVYPSFPDSTSSDRRYMAVVALRDLVAGEEILTSYVDLSSTKAARQKELEERYKFRCACEGCVGRPGDEIDPREALACPATGRTGCRGLIQIPGPEAVPHDVRCPECGSAAPYRDVHPAIDAAKKAYVDADKTQYSDPRLSLLHLGNLISGLTTSLAPSPPIAPSASPLYPALQLLLTLQLHAHQFDEALPTATLALEGARRLFPAGHPVLALLMTTHARLVTTPPASDPARPEPEMQYWMATDRRVQDIKILVAALREVEKAFGDGSKGEARKAVFKGGEMAALLRVLIRDQEEGIEMGRRMKASMAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD54</accession>
    <name>A0A2S5BD54_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD54"/>
    <dbReference type="STRING" id="741276.A0A2S5BD54"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000306">
        <property type="entry name" value="ADP-ribosylation factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="184" mass="20699" checksum="22E1722DC601E835" modified="2018-07-18" version="1">MGVSFSSLFSRISGLWSRQTEVRILMLGLDSAGKTTILYRMQIGEVVTTIPTIGFNVETVQYKNLKFQVWDLGGQTSIRPYWRCYYADTKAVVYVVDSTDRERIGINKAELLAMMNEEELQDAKLLVFANKQDQPDAMTPAEVSEGLGLDTLKNRQWSIFKSCAIKGEGLEEGLDWLATALQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDB0</accession>
    <name>A0A2S5BDB0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDB0"/>
    <dbReference type="OrthoDB" id="2526962at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="881" mass="92902" checksum="B9A538F821C7D939" modified="2018-07-18" version="1">MAPLTRLDAVDSSRSLHPGSGRSGMLPASTSESALAIRTRQGKKVEPPPPPPPAQPKRVRPFILRAKNAPASSAKSPKADLDRGPAIEGDGALRKSKTSFELERKTGSPSKPRKSPQYRDENVPPPLPSLHGTRAGQYNELEQLQPANGLPKRTSRPQSLATSSLRALGKLASSASSAAGAPRRRPLSYVVSPSSPPRSRASLHPVESPVSSPSRTPRFRPRGAAAAHAESPTASRTSSQTATPISSRSLPSQAPRHGGLQRRAESSPPHAIKTQSRHAAVEQHKSALKRKTLEERQARSSPASSSPSLSRSPAVVSAGALLDQAEGGAQPRAGLTRSRRWFGGDPSVQDSTTSDDALWAVEDRALTGQDAYATPPPSIRGSSAIAARKRESYAVLAATKTGAGPRVVTDKDEQQRTGFASLQELLEQHGYAETRVITPHSTTQTARIRSAMADDVRAELLSGADDEDEVEILASPLAGRTGAPSATSGPGKIPHVDGEVESKELKERPSLLSLRGLFSFFGTGAVDVEEALASPELPPSPTGHATAQLAMPDGEAHPTAVAQPRMRTTSEMHRWVETVNEVYPPPIFALPTVLGSTATTSTAVMPELHFDHTVDEDDAASSRSYSSSISFSGSPPTPQPDFGEHDHAFVVSTFSSNHLSPPQYDGDLPRNKRLSLRHTVSDSNLLPSYQSFSGLGISAPSPPPPLVSRSQLSETRPKDSGDIQRTQSPTAEAATGGAGTGLWGTSHLRARASQLFSLAMARSPVDAATGRSFLANASPLSAAAPVSSSSVPTPSRSPFLPTARAPPKLLRKAVSSAGLVSAPQVRRTRVVTKASWESFGSLEAKVSLEERRRSLAGSSGGESDFDGGIGWGEDLLGRAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDC6</accession>
    <name>A0A2S5BDC6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_2246</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDC6"/>
    <dbReference type="STRING" id="741276.A0A2S5BDC6"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="331"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="118"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="221"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY74770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="773" mass="82020" checksum="230AD56AA2B79426" modified="2018-07-18" version="1">MVPVYELATLWEPKSAVRAFLRSGIIINLDDYAHVRGYMAGNFNPNANSFNPNAGSFVPGGAPAFVPGQPYGGAAGYPQQGQPQGNPADYYNQYAGAYAAGGYGGQYGYAPQQGYGQAPAGYDAQDPFAARYNGGGGAPGGYQPPQQQQQTRVYEPPVRSTGPASSAPFVRGTTDPNAPAPAKAPTMSLSIGGGGKTVSLPKADPDAKPASVSLKIGGGSSSASKAAGSSSAAGSSKAATPASSSKAATPNSSKPSTPVAGKSSSAAPAAAAAPAAKKEDKSEAVKAKKDAQAEQKKADDAKKDAVAAEIQAVADQEALEDLYGGEAKDVKPHVNIVFIGHVDAGKSTMGGNILYLCGMVDKRTLEKYEREAKEAGRESWYLSWALDSTSQEREKGKTVEVGRAYFETTQRRYTILDAPGHKSFVPSMISGAAQADVAVLVISARKGEFETGFEKGGQTREHAMLVKTAGVQKLVVVVNKMDDPTVNWDKERYDEIVGKLTPFLKGTGYNMKTDVTFIPVSGFTGANIKEPADRKVAPWVEGKPLLTFLDDMPLLDRKTNAPLMVPISEKYNDMGCVVVGKLESGKIRKNQDLLLMPNKTPVQATAIFNEMEEEVPIAMSGDNVRIRLRGIEDTDIGIGFVLTDPKKPVHAVTQFEAQLVIIDVKNIITAGYQAMIHVHTASEEVSLTALLNYFDRKTGRKSRKPPQFAKKGMKVIALVEASSALCVETFASTPQLGRFTLRDEGKTVAIGKITKLIERTEDLPDVAKLEIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDR6</accession>
    <name>A0A2S5BDR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDR6"/>
    <dbReference type="OrthoDB" id="2528941at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="628" mass="68372" checksum="4F6C7394CDA3DB24" modified="2018-07-18" version="1">MPAVQSTLAGVMTTNAQIAAQWRSLPSLLGRFPSDPARLPTGYEALAGEEVLPPSLLLLYLKPPQNGQLHVLNRAIRSLTGVDPRSLENGNFSVWDKSEDRQALVREWRKEKLPPALSAIYSNTQAQGRASEIDLELLQVIIELFEARGLLSLAELKASIRPSQFDVTGLPRKEHLAELLLSVWTTYSSNKYRGRPTAIVAILGSATAADVPDYDFNPNVDYVADADDDNDILAPMAEAGEALGWSEEKVDDVIEKIVAGTTRKSNAKEQKADPEATKLYEHLWLVLAAQNRASDRLKEFKDHVETAFKNANGATLARQIASGHQRNLNKNETRAGWQYLLQAARDLADGKGFKNKSVKYGKTQWAAAINVVSPYVRTSKQAETWVGSHRAALAFGLVAHDLDPTLIASETFLVTAGFVKSESSLSGWTHRNTLSSDDAKFIAECNKPLVAKEQQDKTVAAPPAAASPAAAASAKSAARSAKDSSSSSEEDEKEDARKESGPATPQRKPLRQNKSEKVSFGSAALPSSSVTGVGVMSSSFSSSPVSSTRVINKRKLDETSPSDTKRIEVAFQHIYLHQVEYRIGRARSDVANDATSDVDSDSHEALTSEDGSELSMEEIETIEYLDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDT1</accession>
    <name>A0A2S5BDT1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1894</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BDT1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1153"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1260"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="395"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="733"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1034"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1343"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="952"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1585"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="978"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1612" mass="176804" checksum="233BFB6828C7B7FD" modified="2018-07-18" version="1">MLVFGAPPAYAGQRDVPIALAVLPHIAVGLCLLLSLAWVAYIHVRAAKRRRDEGKSRGDYGVAHEQQQSLLPGDTAAKPNGTSSRVSTAHPHGHGRNLLLGVFQVTVATAVLVTSGVRLVGLEEGSEYRWIRVYEGGIIAVVFYFALIGTAKMLDGRLAAIVHAQQVVLSCLLSVVVFDVELLPFLFVHHPRRSQFHILGFVQSALIFLLGTLLALTPTSYVPEVPGAQPHPVQTAAPLSRLFFVFIEGRMYRYFARTSSLLARVLPLKSDSVTFKDFVPPLPDYLHSDQVLGRFRWESDEPARSADRTRAKREVVIGRGREFVWEYKRDIAEIVAFATGWIAFVFLSPLSMNLVRPGQNRIVRQLRLTMLICTQLLRYVQQSEAPPLGLSPYLFVLLIFIAPIAQSVCNQAALYRVAQLGLRLRAILGHAIYAKLMRIKAGGTSIKQEEQSDKDGKGGKGGGGGSEAVGRVNNLVGTDIDTITSSLPTGLQMYAVLPKLVVSIIFLYVLLGWSAFIALGSVRSTSARPSWPARLTFPRTRRSRALQIVLFAPVSNLVSKRYGAVQEEIMKATDRRITLVQELLNSIRTLKMFAWEKPSMERIDEARQVELARVKKRAKVYAGLMFLSTGVPAVVTLSTFGCYIFAQKQTLTASTAFTAMSLFGLLREAVISATYLLSAWMRARVSLDRITGFLTETEDLDDEPVKVVARDERSDKENDAAIVISAGTEATFSRYRRGGFVLRLSGGDGKKELVIPRGKTTIVAGDVGSGKSAFLLALLGELHIKKGEIKVVETDGGTSSDRHGASPVSYAAQSPWLQDTSIRENILFGEEYDEERYDETIYACALGDDLDGMPQGDETRVGEKGLSMSGGQKQRIALARAVYSSSKIVLLDDVLSALDSNMVSHVVDNCLCGPLLHDRTVIIVSHFVKLCTTRIDSCELLIKLRNGKVASARPPSETLDAGRNGLHRSPSSSSLRSDVSRGSRREFHSAHVKHGDEQAVDASDLSGSGNGISFSVYRQYAAAMGGASFWTTYALVNIVAHVFMIAQGWFVGRWVNAPDRDAHATRYFALYAGIQLIASVALTAMYMVLIWGAIRASRLLHNRLTRRVFAAPFRWWDKTPFGNVLNRFSKDTEVQDTEQVENMQPVFDYSVQVLFVAMVITVVLPVFLLPAVVISAGFALIGRLYLRNALAARKEVSAARSPLFSTLGDSTAGVTTIRAFGRSDIFATRYKKQTDSYNKMQLCEEGLDRWLELRADMTGALVSFVIGLLCISSGLSSGITGFLISTGLEFTSRILYVVRAINKNELSLNSVQRIIQYSTEVEVEEESTDKKAPPASWPDSGSIEFEEFSAKYGPDSEDVLHDLSLTIKAGEKVGIVGPSGCGKSTLSLAMLRFILTSGGDITIDGRKLSETNLNAIRSRITLVPQDPTLFSGTLRSNLDPTDEHDDATLWNALKRCGIAKSSKNVSLDTPVASSGSNFSQGQRQLIGLARALVRSSRVIIMDEATASLDNESDELVQKVIREEFSGCTNLTVAHRLDTIIDFDRILVLRAGRVVEFDSPVALLDKPDGAFRDMVEATGRFDELYERAKKGGPASKRNPAERPKKSNGRSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE22</accession>
    <name>A0A2S5BE22_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1996</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE22"/>
    <dbReference type="STRING" id="741276.A0A2S5BE22"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12297">
        <property type="entry name" value="RRM2_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034398">
        <property type="entry name" value="Prp24_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="717"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="808"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="586"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="980"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1001"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118745" checksum="C153B6EC3F356A86" modified="2018-07-18" version="1">MADTGSDEALQKYSEVLERLNSALYQRELHVEREQLAKQLGIAEEIEQARQVKSQYLALSTDEWLAWINDRKSSLPQLPADDVTPYLDVIELYRRGSKEYLSIPFLVNWSEWVISQYYAAQGLAPPPTSAGGGEDEDTAMQPAERKVGEPDQLLGVVFSLEEVRDIREEVLAVGGTHLTESSGLWKLWKDFEMDLLKKPALSDADDPPILRPDQLLVVEQLYLARLKVPHLDIAETFSSYSTFVSTFDNDNYDKSLPAANKIYSGNAKKADERYPEEEKLKAAGFSVQAYLDYISWEREVKRPDTPLVKQLFERAIRDSPEDAELWDAYLEFLHKVPAKEAHLRDSTERAIRNVPSSVAIWTATLRIVEKLGLGSEEIEGVFQRAMNGGLLGTDMDAVVNLYHARASYYRRQSDVNASEDGPDGGLVGMALGVLQEGVEATKKIHKKGDLQSRLEKYLIKLYERYNMIDEARTDWAELTKAQPHSYAIWYGRADFETRQGDYAKAHEVYSQGCSARGVDYPEYLLDAWVSFETEYGNLADVEFSLVKSKRQRKNLERRRAREAADAARKAASTYTTATDADAFITAATEPEAETNDKKRERSPQDEAASASTAKKVRIAEPAPAAPPPAPAKTAEEPRRDREHSTVFAVSDGSMSEEQVRQLFSDCGPVREMQLKEIENRTYAQIEFKDKESVLAARTKDKKRINDVELEVYIAWECCLYVTNYPESYDKDAVQKLFEQYGAIFDIRWPSKRYKATRRFCYVQFANPAHAQAALELHGRELEPGHALVAQISDPSRKKSRSDADANKRELYVANIARSAKEPDLRKLFETYGTLKEIRVPTDDEGSCKGFAFVEFEDEAAAQAALALNNHELKKRHISVTIAEKRAAGTARAGHIERRPEVEDLGVRVRGLKIETQEALIQQAFEKIAPVRRVNYIAGTTEAVVLFENAADVGKVLMQRDDIKVDGQAVGITGEAARKAAATGDGPSASLMPRQAGRGRGRIGLAGARGGRGGRGRGGLGFGGSTRPASTVTSSQGDTGAVKMETAEVNSAEKSQDEFRKMLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE38</accession>
    <name>A0A2S5BE38_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">BMF94_2010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE38"/>
    <dbReference type="STRING" id="741276.A0A2S5BE38"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="312"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="569"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="808"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1054"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="670"/>
            <end position="672"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="677"/>
            <end position="683"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY75034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1100" mass="121292" checksum="EC59228C90940497" modified="2018-07-18" version="1">MSGANAQGRRKPLDPRIPALISNNLITAHRSFFVLVGDKAKAHSQIVNLHWLLSTATSSLQNPTDAQKKNPRPNVLWCYKKDLGFSSNRKQRESKVKREVKRGQRDVGEMNPFELFVSVTDIRYTYYKDTHKILGQTFNMLVLQDFEAITPNLLARTIETVEGGGIVVCLLQGMKSLRGLYSMSMDVHARYRSSMSDASPVARFNERFLLSLGSNPSCLIVDDELNVLPISAGKDIEPIDPDLGVGVARSSGKGKRREQEGEAELRALKESMADTKGVGDVLGEARTLDQAKAILTFTDAIASKSLSQTVSLTAARGRGKSAALGLSIALAVLHSYSNIFVTSPSPENLKTLFEFIFKGFDKLGWEEHLDYDIVQSTNPEWKGAVVRVNIFRQHRQTIQYIQPQDYHVLGQAELVVIDEAAAIPLPLVRSLLGPYLVFMASTINGYEGTGRSLSLKLLQQLREMSRPSSALSAPSKDDDGTAVKGGSSSSTLAISRTLKEIKLTTPIRYAPADEIEKWLNSLLCLDATIAVPSKKTLQGCPHPSQCELYYVNRDTLFSYHPASEVFLQRMMSLYVASHYKNSPNDLQLMSDAPGHHLFVLLPPLKEGDNTLPEPLVVVQVALEGNISKQTVLDNLARGKLAGGDLIPWTITQQFQDDDFASLSGARIVRIAAHPDYTKMGYGSRTLQALNSFYSGELLNLDEVAAELEVETFEDVAKIDSDASLATDRIGIRDAAKMPPLLQRLSERQPENLDYLGTCYGITPSLFKFWKRAGFVPLYLRQSQNDLTGEHSCVMLRGLNKNEEEANRWLGAFSVDFRKRFITLLSYKFREFGSITALSILEASSILETLDTRRTLGSTDVRDLFSPFDLKRLESYGNNMLDYHVILDLLPTLAGLYFTRRLPEDVKLSGVQASILCALGLQRKSVEDIETELQLPVAQTLALFVKVIRKLTKALQELLKSDVARSLPSEEAAAAAAARILPAPDATTNGVSGVATQLSNKAAIAKELQAEGDEVLKQLKDQQREVIDSLDLKQYAIGGDKDEWAAAEAQVAAKLAGGKATASSTVSVKNPQSTKGTKRKGPEEQQANGKKDKKDKKRRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE71</accession>
    <name>A0A2S5BE71_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE71"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="46429" checksum="EEFFCDBECF3C7CFA" modified="2018-07-18" version="1">MPASTLPASPLLRLPDELLVMIADCFRAMDSSTASNRALESFAGVNRRLNVVVTPISWQTHALYWGPNSRNKSYEALGRHGKHVKDLAVVLSSHASEFANGFDNVAERVLFCPNITELTLETQATNYRHFGTGSVDNDEDGQFGPVDLGALLAPLQALAPQLQSMDILTNWNTQGLAEDVSSLLRSTRDLRLLSLSPYDVDASFAFDETIPALGCMPFLTSLAVQTSDFLPENAVVCLPALKRLEVAELEPAGLARIHHSVGDTLETLVIENWSDDDNNGTSDSHAKPLLFPRLRRLHLSIYLMPENLLSPFFDSASPIETLSVFSLTAGIFDDLKVFLQKKRRQTLTKLIIENRDDKLVRIGGDGGPEGRRIWRELDIAEDQRIKDCLDWAATRDIVVVVPWCKPPESSAIARTSPTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE88</accession>
    <name>A0A2S5BE88_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE88"/>
    <dbReference type="OrthoDB" id="2501520at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015608508" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28651" checksum="2810E90995F80D2D" modified="2018-07-18" version="1">MLRSPLQLVLLALLALVGLSEAKKTGKVLTTNDKQAASLQAAAVRLKPGNYVFQNVKTKQKLFYTAKYNNIYPSKKGTSASITNYPNKNVAWHRLQFGPKNKCLSSAWGGSSGNNAAVMYVCASGDNSKKTTLERTKQWWLFVPTSKPTVSAKANSNANKVLLAAQADSIETREKKIAAQKEAFHKRMARRVRKRELEKRGIKTVSGGTFYIMPTDHLLDRAAALTGGRITTRGVKNTQLKNWKKGDKAQQWKVTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEE1</accession>
    <name>A0A2S5BEE1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEE1"/>
    <dbReference type="STRING" id="741276.A0A2S5BEE1"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30347" checksum="D0C907120FFA375E" modified="2018-07-18" version="1">MEVWIPRKLLHSSIAGLVLWLWLSHPSLVVLIRSLGATTLVIGTADVLRFRFAWFEQAYEKALGYFMRESERHAVNGTIYYLVGVVWCLSFYPRDIAVLSIIMLSLCDTSASVFGRLFGRYTPPLPLSGRLFGAKKSLAGTTAAVLVGMTASYVFWSKFAARGDEGDVSWVVARLQSGWRGKVNEDPWIGWGLKRLPNPQSTLDLRTLAIVNGLTAGLAEVSNSGLFVLSAVPDLGQERVAIDFFGFDDNLSLPVLFGFFCWLSMYRKQERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEH2</accession>
    <name>A0A2S5BEH2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEH2"/>
    <dbReference type="OrthoDB" id="2529846at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="117" mass="11893" checksum="1CF4B6B2E21AEBB2" modified="2018-07-18" version="1">MPGKRTSSSATASSKSSSSTKTRSQTSKSTQGKPSLLGTKAAPPSKGKAKRAAQKVKDADVRAELDGGNLAGLRQALGSADKNKPIVEKKQAPAELAKGGDSLAKSMDDVLDLLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEL2</accession>
    <name>A0A2S5BEL2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0538 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEL2"/>
    <dbReference type="OrthoDB" id="937at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018794">
        <property type="entry name" value="UPF0538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444">
        <property type="entry name" value="UPF0538 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444:SF9">
        <property type="entry name" value="UPF0538 PROTEIN C2ORF76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10209">
        <property type="entry name" value="DUF2340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16632" checksum="9AD35F8DFF6FCEE4" modified="2018-07-18" version="1">MTTLNGSGADAPEFDDALTNTLRPLTDCFLTIRIIKSFTFRTTKNLLLPHVDATTMTVGQLKDLCRQQVKTAPGFKPYRTCELDTLKLYTTAHGHKTMDLIINHETDDDILTDDSVTLASVGIENEAEVSFFNRALYDEYKANPQQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BER8</accession>
    <name>A0A2S5BER8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BER8"/>
    <dbReference type="STRING" id="741276.A0A2S5BER8"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="165" mass="18341" checksum="EE10FC9C2A1A80F5" modified="2018-07-18" version="1">MTTLDDSSHAAPALDSAPAVPSAAERDANRIRFETELEFVQCLANPFYLQSLAQQGLFEQPAFLNYLQYLRYFRDPRYARFLQYPSSLEHLSLLTAPDPAGQLFRTTLRDQPLMAQEWAGKMVARWAGWRERDVVTTGKLAAGADEDGQQRKDGAQNGEASGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFK3</accession>
    <name>A0A2S5BFK3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFK3"/>
    <dbReference type="STRING" id="741276.A0A2S5BFK3"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="44563" checksum="D7848E4E1DCA0499" modified="2018-07-18" version="1">MSAIATVTSTSSTSQAPAPLWKPASVQPRQLAPLPARKDLPVSSEQADKAVHALLKHAEKAHEKRAKSDLLEATDADEKVFLVVGLKQAPKREVHKPVRIAVPHPVMNPKESPVTLFVKDPQRTYKDLLEELKIGFVSRVVGLDKLRTKHKTFEAKRQLLKEADLFLVDDRVMVEVGKSIGKMWRDAKKQPIPVALQRKGLKAELERAIASTYLNVTTGTSLSIKLGTTALHSADELLANLDAVLPYIATRIPNTPASFSNIQSLHIKTSTSVSLPIYNAALKDRFEGTGLTAAQEEEKRAAKERKDKVAAERKQRDEDKAKRRAERSATKEGKGRLEKKRERTEDEADDDEEAVAAEESSSAVVDAAAPSSDAAAPADAPKAKKAKKSAATTASSASAGKKSKKAKSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFU1</accession>
    <name>A0A2S5BFU1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFU1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFU1"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="209" mass="22252" checksum="166BF159056EF0D0" modified="2018-07-18" version="1">MEADAQASGALPPLRPAAHAQAGGAPHDDVEANLAPAREIEEHEVEMYREQDRYLPIANVGRIMKKCLPDTTKVSKDAKECVQECTSEFISFITSEAAERCAVEKRKTINGEDILFAMSTLGFDMYAEVLKVYLEMQRASGKNALRRAQRAEKAAAAKAKTRAARAEAAGGTADAIAVDGGVAEHGGGGDVAVGDDDQGDDDELEDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFU2</accession>
    <name>A0A2S5BFU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFU2"/>
    <dbReference type="STRING" id="741276.A0A2S5BFU2"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="265" mass="29392" checksum="5D6788F75CEC0DA1" modified="2018-07-18" version="1">MADSNFPRGVPLNPNRNPPFAESAVALYGYIPSETLATIALVTFGLALLNHVVHLIRLRGTRRFQSLLVFGCACEIVGYANRLFAHYHPFVVNYYIVQLFFIFISPVFFQGAFYMALGIALRRLDHHGSTLLRFEPRILIAAMIVSDVVCTILQVVGASLVGVAEAAQYSESRTSSLSSEQANDILLAGLAIQASRAIPLRTASFFAFLILLGLCIWRSHRTFSAAHLPKQFSSTLFIASLLVFLRTTFRLAENAQGQFAFHDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFV5</accession>
    <name>A0A2S5BFV5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_1278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFV5"/>
    <dbReference type="STRING" id="741276.A0A2S5BFV5"/>
    <dbReference type="OrthoDB" id="2536081at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="283"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="577" mass="59781" checksum="B08A6C3D16E102E8" modified="2018-07-18" version="1">MTLCHDDYEYDHVDAVPPALECPICRSALVDPVQTPTCDHLFCRACLEKSLSLNPSCPIDRTRLDSVQACSTPHRAILYLLAELRVNYNGRTVTRDEADRLARNAAARPEPAAATETATTTPPPPTAMNDSSDGDDDSPTACDYCTLVLPRSTHPTHLLTTCAVVPLPCPHARRGCPYSGPRALLEQDHLPSECVYEPIRAYLDRTDEVHARLEGDNWELGAKVATLERTVSALVAAVRGLQASLGEFAPVAALPLCPAGGSIASARGDASGSMTGRPRPAKRAASSPSTSTPTRDTPLPLPSREAAPVASSPRVAAPTATASSPLSSTLSHLESTQSHLSSSVSTLLQSHSHSLATTRAVQEELASLRTQLTGVRIQMGGVMRDVYGAGYGSGGAAVGRRMRGAAGSGGGAGAMGGYGGGTGTGGRLGSQVPALRPHPGLGSSGSSDEDLLGHHHHHAGGTTIPLSSPSSYEDDEEEDETEFYHHHPHPYSTSRSAPGPARPGHGQPHQFPFWNANTAGFAPGTAVPLPMPMPFPNGMRPIVPGHFHPAGPGMMSVGGGVGGVGGGGGGGNGLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGB9</accession>
    <name>A0A2S5BGB9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGB9"/>
    <dbReference type="STRING" id="741276.A0A2S5BGB9"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF12">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="359" mass="40000" checksum="AE2128FA8E175B4F" modified="2018-07-18" version="1">MTRLLRVAAVQVGRVDRSTPRSQVLARLISLLEQAARQQVKLAVFPETTFTTFFPRYWIEDDTEVASFFEKEPASGIADCAAVKPFFDKAKDLGVDVAIGYGEETPEGTRYNTASYVSNGQTVSKYRKIHLPGTFEPLRFLSSLTETHPTYYISGTFEPFSKEPGVTNQLEKKYFQPGNLGFKAFRAPSLRATCDGDKSPIVGQLICNDRRWAEGWRVYGLQGVEIMCIGYNTTAWAPQLWGIDPDLMTREAAYADAIFHHKLVCQAHAYTNSTFLITSARCGVDDGVHPLISGSMIVDPEGHIVAENKTEEDEVVVAEIDLDACQQGKNKTFAFAKHRRPEHYSAICDRAGVVEPEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGC2</accession>
    <name>A0A2S5BGC2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BGC2"/>
    <dbReference type="OrthoDB" id="2530022at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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    <feature type="domain" description="Zinc finger PHD-type" evidence="7">
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            <begin position="312"/>
            <end position="357"/>
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            <begin position="375"/>
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            <begin position="1972"/>
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            <begin position="2052"/>
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            <begin position="2091"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
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            <dbReference type="SAM" id="Coils"/>
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            <dbReference type="SMART" id="SM00317"/>
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            <dbReference type="EMBL" id="POY75817.1"/>
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            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="2138" mass="219186" checksum="7D3545149C795272" modified="2018-07-18" version="1">MPSALDLLSAAALLDQPTADAAFTPTRRPDPSAAAEQQQQHYDSTTPQANLPGYHVQHGNLADIARAVINFPPPPPPPAPASIVGLQGRQRVPSSSGSTGLFAQLQQQQQQQPPPVVVSLPPLPPAAAAPPPSQHGHAAHSAAVGVASPPVAATHSHGTRRQAREQQQQQQQQLSSSRRQPLQFYTASDGTAHLGRSVTAAAAGGAPAAGPPPAAALPPLPALPLPSTLPPLPTLPGAPSLISPLPTYHAHSIASPPSSSTQAGASLPHSVPKQQQLSSPSSSAGASSSSAASKPKRPPPAYAVPPESGLIRCVCPYSVDDGFTIQCDLCNVWQHAACVGIPSLVDVPDEYWCERCDPVGARERGVDGRLAEVGMRVRMREMERVQEQIRRAEALQAQHHQELLLAAAAAAAATTERDRDREGGVDVPKRPSQYHQQGGATNAFGAQLPQLQQSASVTTAAATSAAAAAAAAAKAALDDDPDFTPHSTTPRSSRPKANKPRRSGGGGGGANSVTATPTGPASSAAAAAALTAPPSSSSGQSMSTLTSVATAAAALANVTASPREPKRQSHETPATATATATATTSSPYRAAGPDVDRAKPKRDDGTARIGADSDTVMATSDEAKAPATATDEPFKPDRVESTRQPGSEDASKLPPPLTVPTKNPVSVGRKRRVAKQPKSRATSTGGEATDDGAARPSTTAALPTEPADGGSRLSSLRDRDRSARNASASASAQDESGVSSEDDERPSTVAVTSRSDRQSRNVVANDEDDRYDAWQYEFTPVEANLYPDSALLDHLETVLGQPPNALLLDRRDETGSPAWHSLRERQDAMRGVAGGRTGARVVEALLDLQPAYVELATLPPTGPIAVKPLPLSATNMSHPPIQNAYIPTPHSASLHASSAAAQAMCPYPRPKSFALFATAPIPAGSFITEYSGTVTDLEAYRSDPINQYPLAGTPKGAVRALPHPWSVVVDARQFGNEARFARSGCRPNAVLRVVKVEAGPTTNAAAPAKRRQKRAGSPAKGRSRSTTPLPGANAGGAEGPQWAAQRSGHPAAESFRIAIFALTDIHKRDEIVLPWDWDDAHLIHLLPSLLALPSAVTSPSLLESLSEHLDAAANLSRAMAAVADVLLAPASSSLNGGCACERKKECAVWWLARGGAASCFSLTAKGGGGRATHDVGVAFLNAFAGANGRDKEGADPSIAKRKAGSTQARQIDLGALVGLERGWIVTEPAKAEPIYRKEDPAAVSEAEREGAVSESDDSMSVDEIEATAQKPIALGKVDAISPSSALTSLPSDDAPHPRPISSVARPPRDGPTQVRVDGADDSDSSELTEPLSNLSALEDDADSDDDLSEPDETVLSPPLFSKAGSALPRLPSPVPAAPKKKPAARKAPTAAKSVAAASTRSSLSPKPRAEESTAKDKACSKSGPKKRKVARVYSSSSESEHEAVSRTSSQPASRAMSEDPAEKTDRAPPSTAVSDETARAPVRGKKRPASATPHGLAALKIRKVKKRSSQNASDDSDAAPSPGIDALATRDDDSLPPETRRETREAAAAQTDETAMASTATQAGDTVETGSLPREQPIFPSPAQPAPPPPPPPVRSRLTFAEYRQRQMRPPPPPPPPPLAAVSSASTTSAGVDPVPVPSISTSQSAVASAPPPVSVQPSAASPVPAAHPLAGVTAAQLEALAGALKAASSSPSMTPTMSLATLSTAVPTPSPASQSRLLPSETPPLPQAFLRRAPPPPPPPPAREVLGSSQRRTSDSRKLEAVSGPQLHAAPEGTVRARDDEPEAGTPPLPPQRDPEPIADAAMLPPVGEKEVPPGSGQLSAADILKSIGDYFGSSSGTPPVARPARQLGADAAAAAQSPSAVSQGTPPFPPPRTPYSQSQRASELPAGSASGGTPSAQSLATRRPSVSQTGSALGLHSASLPSFSSSVTVAAQPPAGPRASGPLPMPGFRPISAQSNPATSAPPNAPTHPRASQSPYGRPATLQQSPAGAFARAPLPTGPPLRQASVSPALGLSSLPQYAGGSVRPSPPVRPVELGGAIPTGPKAMQSGLVPPASASRPPSVGSNPPTTPNTPSQALPPRNGWGSAPRGRGSGFGGPPSGPRGGHSGPPRGRGGSAGPGGGWGWRGRGNGRGGRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGF7</accession>
    <name>A0A2S5BGF7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small nuclear ribonucleoprotein Prp3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phi-like"/>
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        <property type="entry name" value="Prp3_C"/>
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        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF10">
        <property type="entry name" value="DUF1115 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G14750)"/>
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    </dbReference>
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        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
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    </dbReference>
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        <property type="entry name" value="UCP038021_RWDD2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="2">
        <location>
            <begin position="205"/>
            <end position="269"/>
        </location>
    </feature>
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            <begin position="172"/>
            <end position="196"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="348" mass="37837" checksum="5E3EFF4E3509044C" modified="2018-07-18" version="1">MPALLARTALATHLETVELIQGLFPGDDELVLSDRTASFLPTLRDWIEAGADEDNDPITQYDAPDELGLTIQLALDQQDAETAYALPLVVRLPLLVLPQPSAPDPALVLRDGAPLAQIHAVQPSWMSRTSHDQLVGALSALTSGPGSADFASNVDLLLATIDQIRSMTPALLPAPTEAPLPPSKPARGKRRRPPTGVDEPEYRVWFWFPSLSTREKRDDMVNWAPEYNLTGFVLAGKPALLCVEGTESNVQAYLSDIKANSWADIPSFQKKVSERFRTPLLPPLDEVDSTPTDPTVHRLFTSMDEITSLIPRGGYRGHKPEMGDVRDFLTAKGLGTAFGEVVGGGQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGW1</accession>
    <name>A0A2S5BGW1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_1080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
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            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGW1"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY75995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="533" mass="57139" checksum="750E18B806B6DAA4" modified="2018-07-18" version="1">MEARKPMLGPIELLPTELVTLILAFASRDGRRKGVLARLALVSPAFAASARVLATRNPSLFSFADAQGFVRQLQRDPSPSRRTAAVRSLSLAYSAATQGAGDGVTALQAVSSETGRLAVPLSLAAPILYFLDRLVSLDLQSDDGLALLDAVVQQGGSGLAALERFSCTKVRWDRLVRLLAESRSLRDLKLGSLYLHVETAPPGDGAAEPDAPNPCLVDLASFGLPCADQTFPSRLAYEDAVPVHAAPLPFPTFALRSLALHRFEGTDGTFVSLLNSCRSSLDVFSLTETTVVSRHALVAGLRLLGSLSELEITKCRFKAERWMVAPGIGMRNAPPVAGPLPSQPPQQRGYVLSPPAVPTALIFRPTAPAPPPPPPMRNGPEDSDWARVIHASLRLLEPDTPSRAALLNPVDRYELQYPLDSLARHCPFLHVLTLVDTDMVLSTHGIEQVLGGLPLERATIGFKRPHVPVEAVRLGMKASRGRLDAVTITVGMRWSESELDSLRASAGATGVLVSGEAYRPPSREDILAGFLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGX8</accession>
    <name>A0A2S5BGX8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGX8"/>
    <dbReference type="STRING" id="741276.A0A2S5BGX8"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="46619" checksum="332DB2CB31B65BBB" modified="2018-07-18" version="1">MSASSFAGAPLSKAIVLSTVALSVLAAAASFQHHLALSLAPHLTRDHQLYRLVTHHLAYANSSELLLGTLVLWQTSPGLERLFGTRKFAASDFLPACALSRHPADLATAQSFIVITTVIATLLEVVALGLGWRLSKGTLNSFPSGPFALVSAIAWQSHRLVPTLYHFRLFHAVLTLSNRFPTYLLWTLFTLSEPPSATLLPSLCGLVTSIAYSSNLLSLKDYRLPRRFYHACARVGARVFGSDAASRARVRRGTAVTAEEALLQSVAASALAGPMMGGARGNGGGGGGGGGGVNGLAGGMDASILRSMGRATRQQEAAAATAAAAARAGGGRSPSTTATLPSTEVERLSATAADSTLPASPQAESGATPAGAGAAAAVGPARPPSLSRLTGASFLREWQAGLTGAPEGPSAAQINELTSIFPHHTRHAIVAALLQSELDTSRAAEILLAQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGY5</accession>
    <name>A0A2S5BGY5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BGY5"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1091"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1250"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1386"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1410" mass="157693" checksum="5ADF01241CF60CE6" modified="2018-07-18" version="1">MAPRAPPSASQNLLAKANAKAQRNASIQASHAISRRRTTAAGRSLIGLGRGGDGGPVHGAMYDAEDDPDRLYYLQGLGRLDIDEDSGDEDSDALAEGDFGWGYEERGDDDDDEDGDEEGGDHAGKKRPPASGYHRPAVSYNLNPAGYISPASEGTSSGEEEDTPETKARFEWQHMLNNVLSGNVLKSEKTRLSTASLSGTKSLKNGFIDSFSNGRRQRAYAIWLLLRAHVRGRTPDEESRFLEEARSKVDEVIDELAKFRVVNLEQEPNGINLDDAIRQRNAADQVASLLKRVEWCETLWPSRRALVLEKDRLTDDTISRRLDALRTWQQITHRLKVTVGIVQKWTGSDWEKLSQTTTQAADHADGTATESDGGGPDGSDSDGEGTPRASKDRKQSPSSDTRSPGTKSVTAAKGGSLAANGPDGTTPTPSPQPPIDRGFVAVIVREDSLAKTFEKRILTDLYTLVDTAKAAVIEYQPYFTAMNLPGFTDDLFRLAIFPSRLAQEALRTTLDSVANISDPSVVLIDQLTNDLRKGLEVACQIKRQYTELATPDPETGWALQERVDGYEETLLATLRFFFKLLHWKLKSPSKAIYFKETEIVENEWGFLSTVTEEIDGGDLIVGEHFSTLTHRLLVRVMSYFETQLQVLETRDMTAQETSRWFSQTLDNVRARHRKLLRFGRSMLLRFENSAEYTLDHIDLRSFIDGLVESDHFMVYTGVYESEAVYIVADPSLHEQPELVRQILVRCFSNETQGDLLDSLEDLMHYVLLLSPREPFLWTGRVMNLDLGPKVDFDLREKRVRVVSDGPAARLARSKQTFVDLFPAFRRNVIVEQKAHLASVNRETRKIGRAIFRLAETVLGAHERVRAVSQRRPGQGQELLGGYFTFAADLGTRSLRYLEPSLRARFFNQLMHFSIQWIAFICDNCVPTDPRTFRWAVEALEFAMSVTKNDNILKYSDNQFALLRSKVASCMTLLISHFDILGARSSYEAKKEQERIDAARLATKEQLATRLAALRRIRQRADGDSSDEQSSIGSLHLAQEKRIQALQALEESRKSLESGNRMVGRVLDHDIAEDRSLAFLASSSLSNISIRWQQGKFIGGGTFGNVYLAVNLDSGEELAVKEIRFQDLQTAPHLINTIRDEMKVMEMLRHENVVTYYGVEVHRDKIYIFEEYCPGGSLANLLEHGRIEDEIIIQIYALQMLSGLIYLHSQDVVHRDIKPDNILLDGNGTIKYVDFGAAKVLAKNQKTLASRSRMGTRGATKGDGGAPDANSLTGTPMYLSPETVKGERRGKKGAMDVWAVGCVILECATGHRPWSNLDNEWAIMFRIGIAVEHPPLPEPHQLSELGIDFIRQCLTVDPEERPTAEDLMSHPWIVDATMQIQQAYETETPGLGGMPAQPTDAIIPEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHI3</accession>
    <name>A0A2S5BHI3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication complex GINS protein SLD5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHI3"/>
    <dbReference type="STRING" id="741276.A0A2S5BHI3"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="2">
        <location>
            <begin position="290"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="342" mass="37734" checksum="4BE5C8200C322E70" modified="2018-07-18" version="1">MSRPARGFFDDDDDDDAQESFQTDRAVHGDADSLDHDSLNARGQSPLLPPLPAQYRDEYDRGSSVATGDRTHAGRVSSVTGAAMGSSVRGGVGTTMNGYDSMRGDSPSLDDIIAGGIGARKRGRNVQALLQAWQNEMGAPELLVFPVEIVERVVKDLARRKELVRKAQSTAGMDESFYLAATVVATENMRASHALKMFTRERIWKVGLGRVMRRARLAESAERRLTRLGEQLEQCPEYYLSQADVKHRLYPNEVAHAEGYVRLVKAYHDACAMDAMPAQVARQPPPMPTPDFSKPVFFRARKDCAPVVLPDGESFTFTAGSQHMCRYSTIRALLEAGDVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHJ9</accession>
    <name>A0A2S5BHJ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHJ9"/>
    <dbReference type="STRING" id="741276.A0A2S5BHJ9"/>
    <dbReference type="OrthoDB" id="2528262at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="59"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="764"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="847"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="913"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="960"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1013" mass="104761" checksum="B23B5AB80A6D53D4" modified="2018-07-18" version="1">MASQAQGQQPARLSVLSFGTAPPPDVAQLPTAVPLALYPQPHPATTDSITAPPPPPVDLTHVARTVLKAKRVAVVCAADTMGLTAFHPQPGAGISTASGIPDFRSGAGLFESLKKQYPEAKLSTGKDLFDVGLFASETNAAIFFNMIAELKKQTDAVQPTAFHDWLKHLDDQGKLFRVYTQLGLATANRNIDALEEKAGLTYGLGDKSLPLPPRRMGTAAPPPRSPSKAPTASSTASTAQSTRTSTPVLSGSALSSLPSSSAAVSVSLEPSSSQVSIASTIPEATPRLSASPAPPPPPAAAATAAATATHSSIPRVIPLHGHLSTLSCSACKHEVALSGPYVDLLATGSAPICPACLSIDEARSAAGERSRGVGMMRPDVVLYGEEHKDGDRVGEITQRDLMGQRPDLLIVVGTTLKVKGTKRLVRELAKVIKPVASSTPTTTAAESDSSASTSTSGTTKQTRSSLAQEAAANAAAAAAAAGASASQPPRKRRPARPAPIHTLYLNYDFPTPAREWGGVFDCWLRGDIQEFVEAVKREEVAFKKEMDDREKKRGEKRKRDAEGAPAAGGAAAAGGATKKKAPGPAAKKVSAAAAAAAGAWTSAQRPLVPAHSAHPPSPLKPPPKPAQSPRTDPNKRTRSSVHMPALAGPVPGFGVLPALPQLVQPPPVQPTAPVLPSTAFAPVAPYQHYQMPWQAPAGVFAPFTQLSQQHQVQQASPATFVPSPASTSTGSHASSVMQSHAAVWQGVPTWPPYAASDQTLSVGSVETAPTTAGSSGVPSPVKPANNGMPQQAETVTTEQWRAPLRRKESSSSLSSLSSDDEEGDDSDDDEPVHSPIAEEPMKKEEAPALVAPVAPKRVRASLPTRPRPSMSTRSSASGSSNASDSNSPSVVAVDATSAQAKDDSVGPKRRSSRSSTASNTISSIEAAILRRKSGSRSPIMSIAADSIAVRAADRRRKSLTPPTSTNGKTTTTAAAAAGAVKPTKLPYPVTKRSVAGVTGTAAKGGRKRRGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHX6</accession>
    <name>A0A2S5BHX6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHX6"/>
    <dbReference type="STRING" id="741276.A0A2S5BHX6"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="3">
        <location>
            <begin position="78"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Tandem CCCH zinc finger" evidence="4">
        <location>
            <begin position="406"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="54211" checksum="A5C7ECC107E8940F" modified="2018-07-18" version="1">MQQQQQQQAADARSQLFDNYVYYAAEAARIARDACEGTDELQKRIDQLESELQVWKLGHQEASKQARDAQKQLDIGDQIAYCVLDGDGCIFHRDLISKGREGGREAARLLSEHVTNYAEDQGVKGQLTVIIHIFVNKQGLGKVLSSCDIADEATFSAFLLGLNAAHPAILVSDVGGQKEASDAKLSHSLRLYAKLPSTKVVIAGAAHDGGYAHLFSSLETEAPLLFRKITLLKSYVDSAFEIKRLSLRTTFFEGLFEPRKLVAHGSSSGTTTMAMPTPKKTTPRPATTPGPPVVGSATSSGSNNNSNNNQATPKASKPDSWSTLAATKPIKTAPVDEAGFTKVVKVKLKPTDPTKPLFKQVPPVCNQHYLKYVPFITPSDVFETVADATRCSLQPAVSRELPLVELKANAKKSPCLWALKGKECRTPGCPLGHVCPYGKQCKYGDTCRFSTPGLHPPGTPGRRDGPAWKGNTGGPAASASKGKKRATGTDGEDDSGFETTSSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIK9</accession>
    <name>A0A2S5BIK9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 14</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Deubiquitinating enzyme 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin thioesterase 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ubiquitin-specific-processing protease 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BMF94_0206</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 27">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BIK9"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007402">
        <property type="entry name" value="DUF455"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42782:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42782">
        <property type="entry name" value="SI:CH73-314G15.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04305">
        <property type="entry name" value="DUF455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rieske" evidence="24">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="23">
        <location>
            <begin position="623"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="22">
        <location>
            <begin position="776"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="21">
        <location>
            <begin position="1090"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="21">
        <location>
            <begin position="1153"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="964"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1198"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="973"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="POY76616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1297" mass="141774" checksum="3DCDB7EF24820BD4" modified="2018-07-18" version="1">MRDPALGPGWILVGAQSELASSHRHVVGLRSWRTGEHESLLIYRQDPLPSSISLDEAPRERARYYALVNECPHMGLPLEGGDIEDLYPEIDDDDDGSPDPSALIICPFHAYDWNLSDGISSTGMKACTFKVELRDNGEIWLEAPGDPGDDYRVIGLRAVSERFAETLASDPGALPLASLSLSDSAFSEVGGEPQTIVAYCRAILHAPSPAHKVALVRRLVSSFRSGNLTRLTDSKSDPPHPEEPYRAPTTKTVSSGQTRPLGKGGSVQTRIRMLHALANIELWAIDLAVDHIARFHDWRLGAMEGDGKGKRIGWSFVADFLKVAEDEAKHFTLLSERLEKLGCTYGELSVHNGLWESALQTSHSLFSRLAIIALVHEARGLDSNPMQIRRCRAAGDEETAQVLEIIHADEITHVAAGHRHFTALCAAVEPEPVDPVVQFRLEVSQHFWGHVRGPFNVEDRDRAGIGRDWYDNLECTQCFDTHDHAAGIDVCLSCFNGACPPEINGVASTNAHGKLHYEKTGHAVVVNIQRRKKPQAEMKTSKRDSQEPPVKKLAIREEPSEEEKYDFVTQVRTYTGGESNRSQAQYVAVDEVDETLNGLVASVLSAMSSAQKSEVKAWEEEIVPCTHTRELVQPEPKKLEPSGLASCAYPDCGLNSNLWLCLVCGALGCGRQQYGGGGGNGHALQHTTDTGHAVAVKLGTIEPDGSADVYCYACDDARVDPHLAKHLGNFGIQVAEQKKTEKSMTELQVEQNLTFDFAMTGADGKELEPLFGPGLTGMKNLGNSCYMASSLQSLFALPAFQDRYLTSFVVHPSTCSSPSPATCFECQMSKIADGLLSGRYAVPHVPEPSDALAESADAKVDDKARVHFQEGVRPAMFKSLVGKDHPEFSTMRQQDAGEFLAHLLEYVRRASKQIGADEPTGIFGYATEERLECSECHGVRYRTHKDEMLSLQVPVKERQAMQVENAAGTDADEQSRSASEQDKERKVEYEPVELTRCLDDYTSPIEIEYSCPACEKKVTALKSTRFATFPDVLLVNAARFQIDNWVPRKVDVPLLVPASGLDMSSYLSAGLQDSEKVLPQDAAAAPAEPQFDAESMTQLTGMGFSEIRAKRALLATGHNGAEVAMNWLFEHMEDPDIDAPLPTSTNAAVTAVAGDEPTSDQISMVSEMGFSAAQARKALRETGCNMERAVEWLFSHPDDDGSDLTPAAGSGVGKAEQPGSTNLPATYRLKAFISHKGPSVHSGHYVAHVWTGQADRNGEGKGAWVLFNDEKVVRADDGEQAAEKLMPLAYVYVFERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ00</accession>
    <name>A0A2S5BJ00_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BolA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ00"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ00"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15593" checksum="B265FF0F62A7190A" modified="2018-07-18" version="1">MLLSRVAPVQALLFAPSSIPARSRLWPLFRRPLNAATMATAGSNQAGPVETAIREKLMAALAPTHLEISNDSHAHRHHAPMRAVGGGSGETHFSVQVVSEKFQGLRMIARHRLVNDSLKDEFAAGLHALSIKAKSPEEYEAAGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ57</accession>
    <name>A0A2S5BJ57_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_0056</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ57"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ57"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="108"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="259"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="459"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY76804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="67945" checksum="BBBF541E197421BF" modified="2018-07-18" version="1">MSAPGQLNDNEIYLGSFLLERLAQLGVNKLFGVPGDFNLTFLDLVEEHKQVKWIGNCNELNAAYAADGYARVKQAQLNATHETATDNSTPGEAKDKDGNEKSQGGVRGLGALLTTFGVGELSAVNGIAGAYSERVPVLHIVGVPSTKLQKSKALLHHTLGNGAFNVFEQASQGITCARAFLQRAEDAAAEIDRVLFEALKTARPAYVTLPTDLVFTPVDKKRLDTKIIPDRVGFHDKSVLPTGRKVDDDEKKRLEFVVSEIARLWQNAKEPIVLIDACAIRYGVGHLVRDLIQATGVKFFTTPMGRSAIDEDPANGFGGVYVGAVTDPKVKELVEKTDLAFMVGSLKSDFNTGEFSYDFPQENVIELHSDHTLVQYATYPEVSFHQLLPALTKKLERKRNVSEPPADLGLKVEIPDSPKDKMVTQAAFWPMMGQFLREGDVVVAETGTSSFGMIGTPLPKGATFVSQVLWGSIGWAGGSTLGALLAAEESPTPRRVILFTGEGSLQLTAQEVSTMVRLNLKPILVVLNNDGYVIERKIHGENAGYNDIATWKWSQLLDTFNGYAEPKPTKSLLAKTRGELEAILADPEFGKAEQIQLLEVIMDRQDAPEALIKQGKLSAELNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJF0</accession>
    <name>A0A2S5BJF0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJF0"/>
    <dbReference type="STRING" id="741276.A0A2S5BJF0"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41241" checksum="DED83C423AA790D1" modified="2018-07-18" version="1">MSYEGQTHHPHTPGNPPNPHLIPLAHYNDHTQPYVPAGLELVQAHWFVRHGERAPVRQRLVGVGEIPAMFPLCSIGRDFRTSVLAFASGSPSTDGTPPPPPASLPTLATASGRVEASTMEVRRLAEDVDSSARGTVGGMSDCYWGELTDLGRRSTLELGARLRSLYVDQLGFLPSTLDATSSPSVAFRSTNMPRTIASLHQIVEGLWGKDRRDPAYRVAFTIRGWQDEDLYPNTSCRRLRALDTASIAKAAETNDPALAELDPALSHIVGGPLRLSAAPKANGVLDTAYCCRAHGIKLPRELDDPNVLRKLETAVVHEWFDGYKNPEFRKLAMGRLLGSLRQSLDAKIRSPADEPTKLAVYACHDTSVAGILNALDCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZF0</accession>
    <name>A0A2S5AZF0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_7054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000164">
        <property type="protein sequence ID" value="POY69922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZF0"/>
    <dbReference type="STRING" id="741276.A0A2S5AZF0"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="3">
        <location>
            <begin position="283"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY69922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="690" mass="73618" checksum="87161E68E4288C45" modified="2018-07-18" version="1">MPDSMGSSEGGAPASTLTHLSRRSWALLACSVSVTVCAVLTLLASLARSQVSSLELASTAEGNDADIWSNPLMVSLSLAILFGVGAVLSLVLYLLCHSAASVEGTWLRWTRIGTTAFSAVVLGPWCVAGGIMSFGSVKEQVQKACAVIDTHCFPSYARLEWISIPAEVLAIGAIAWMLTAVQRYCAELGIGILSSSPKSASMRSGSTAARSKDEERGLVDAVNSNNSLARSSKRSNRRRSERHLLEAGKRRHQVAQNSEHQSTPLADADEEVPLLVEAQSKVPMTIVTGYLGSGKSTLLDYILKEQHGRRIAVIMNEFGDTSDIESKAISVQTDDALVEEWLELNNGCLCCSVRDTGLNAILALMEKKGRFDQIVLETTGLADPAPIIQAFWNEPALNLDVSLDAVVAVVDAAGIEMQLREARPDGSYNEAQRQVATADVILLNKVDLVPTSADLDRIETSLRAINSTALIHRTTRSSIDLSLILDLNIYAAPSAPIHAETLAPFAQAGAASTECDDCSTGHPHTHSQLPKEPSAGGTLASSAHANDISSVTIPLPTLRAVHSGSAFHRIISDLLWEGLLPTLDDKPSEARPEPDSIDLLRTKAFLRTTDGKAYILQGVRDIFDLAEVPPGQGVNAAEVEPKLVLIGRGLGDGVDVRGRIEAGLRRGVAEEAEAEDSADSEEDDDSDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZT0</accession>
    <name>A0A2S5AZT0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000153">
        <property type="protein sequence ID" value="POY70040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZT0"/>
    <dbReference type="STRING" id="741276.A0A2S5AZT0"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="103" mass="11757" checksum="E8694E02FA805433" modified="2018-07-18" version="1">MATTRTNLPWGLNRGHPTTVIPKAVKPSNRKGKQSQRAAFVKSIVREVVGFAPYERRVMELIRNSKDKKARKLTKKRLGTLRRAKRKVDELTGVIAEQRRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B016</accession>
    <name>A0A2S5B016_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sulfiredoxin</fullName>
            <ecNumber evidence="2">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_6991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfiredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000155">
        <property type="protein sequence ID" value="POY70001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B016"/>
    <dbReference type="STRING" id="741276.A0A2S5B016"/>
    <dbReference type="OrthoDB" id="10023328at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY70001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="122" mass="13667" checksum="F108C7F8A466E6BE" modified="2018-07-18" version="1">MLHAPSDRDPAPARPHVNFSKFATGDLPTVQVPIEVINRPIPSVLEEDKVLRFMHDIQKGDSLTPIEVLKCTAPDGQRYYFAFGGCHRFEAHKRLESETIPSRIIEVPPSALRLYLGASCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0L3</accession>
    <name>A0A2S5B0L3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0L3"/>
    <dbReference type="STRING" id="741276.A0A2S5B0L3"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="35512" checksum="55E34F3953177C84" modified="2018-07-18" version="1">MAPSNAVSPQQAQQKLYRTLHDQLDLALYPQALRTVNKLLARDPQDQLARQTHSQLVVALDRYPDALRLDSTDDATRAYCLYKLARPQEARTVLEQAAGDDRANQVLEAQLSYRLGDYERARDLFDELAATAEADSPELADLEANLTACTAQLDFVAEIPTTLANLSSSGSRAIPPIDELEARPLALVLPAASTSNLGGGAAAAAAAAATDRGKRTRTARRRPRGARFAASATTTSEEGAPFLRIPAELAQQPAPAEDRWIPKRQRPSMRDALLQAKEKQRGRKRDKVLAAMAATQGAAAVPPPSDEPKAKATGAGAKPGGGGNKKKKGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0P7</accession>
    <name>A0A2S5B0P7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cwf15/Cwc15 cell cycle control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0P7"/>
    <dbReference type="STRING" id="741276.A0A2S5B0P7"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31737" checksum="8BB6184B71F0AC5D" modified="2018-07-18" version="1">MSSAHRPTWTPAQGKEGRQNSRSYSSRDIAAHTKLKFRQPGQGTKDEHARRDLKLELLQAERDAAARKAKGERGYVQDQKLLALASSTTTGDAPTTENGESESAAKRRKMLQEVADLDKDDSDDDDEADEHDGAIGAKQDKGKGRATSNDDDDDDDSDEDSDDDDDEDETAELLRELEKIKKERAEEKERQERERAENEQVSRDEEIATGNPLLNLQAALGHSPAPSTISSSSAATSFGVKRRWDDDVIFKNQARGVSETPKKEFVNDLLRTEYHKKFMSRFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0Y4</accession>
    <name>A0A2S5B0Y4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B0Y4"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="4">
        <location>
            <begin position="1916"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="5">
        <location>
            <begin position="2578"/>
            <end position="2840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2656"/>
            <end position="2683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2807"/>
            <end position="2860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2501"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1352"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2658"/>
            <end position="2671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2672"/>
            <end position="2682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2819"/>
            <end position="2832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2845"/>
            <end position="2860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2860" mass="313121" checksum="8EAB439D754BF982" modified="2018-07-18" version="1">MAKGGSSASRKAQPKSNGATNGNGTLRSLRHAASTSSAAASKPAKKVRSTASMTVAEKIAKRGAKPLVKGNNFRFVAPSDRMAKMKVDLEGVRDRREMIEGEEEAEGDDMHSLFGHALQQSQLINLSLPFIRFSKRVEPYSRSLPLVVHHRRELVEAVCQVLAGPSNEVELCGESILDLLPPLITDVAHLLLPSLPLLLVTLIRLTTPSPFNAANPRILQRVYDVLGALFRDLARDVLAASGEQDKGGLLEVWQIVRRGLGAPAPPLADEAEQMLVEGGQAGAVGATDAAAATESDDASDDEAEDVVADLPVASTSAKPLGGPAEDAQKLHTALPASFRTTPQTRRLLANAFALLVRKAKPASSEDVETLAGSLDGVMRLVIGDVAEVEELDGGERANGGRGAKGRRKGKGKGRGQEEGSSNVFAEGLTWLVAESCSAPNHFFHSRTPAILRAALHAIVALPRLADLSLPTEVVSHAYVTLTVYAEKKELLEPVVETVIKVLEAEVEAAVSTAEAGWDRICVPLQAIASHVGVQEGARLPASLKPRLLASLAPLSRLLTQSPPAAFLHALNDFLATLLPLAVLSDVLASNVRGLIESFFATDASETVFAAGCALASTLDEVAWPLWDTAFGATLLGATARELSASKDKKGKAESTDGSAFAEASIRDNSRALLAHLASTGRLQAVVDKGGAALVAWEKSTAALAQSTISNWQSAFAAGRTDLDDLDLELIDMLRIAPHLPQHRQAILPVLADLAAVVAKTPSSEARVAYLSSPANPAQVLASVLAAIAGISSRMKKAPSMAESLSNSVEAIIANFAWHRQVMHGLSALSLARNASNRSGTTREAVEAAILPNLLSEDTVLRRSALEIAMSLYPASETPTAADLIAKCIEVEDMPLTVQGAREKSMKVRRLGIVAHAQLGKEGSTEPVEPVLNIILRYLTAMLKVNFKPIWPEATAALALLAGRYPEQVWSAASRQLLAAATRGTDLFVTRKPDWAVGASGASGEVDLVFDEQALRDWHLEDRRAKLRRAEHRFEGNAGDELARTADLVKAQVTPERLVVSTYEAQLLALFCQIPDLAQKHSRQFVDVFLGCFQRDDVIPDNADEVPEYFNPDETSKDRKARLLAWLALFAKFTNPKALYRASDLDSQFRTLLAFPDVDIQKLALDCILRWKIPSVTANADRLKNLLESTKLRDELLQFVSTTDAGGLEPKDRADVVPLVIRIMYGLMISRLGRASASSGQGRAGRRAAILGALRTCTPTELDTLVDLLLGPLRKLLVPTASETFEFASVAPNVPGKRQLGFLGLLADVVKHLGKDIVHRWPDLLGVVVNLLHFAQRGLDDEAAAQQNAIDDAKEDEVDDDEEEEDDVDEPQHAPLRHIRQTAIKRFTDFFRLEVDFDYRPYLHAAFPSFISPRLPKLAAENAQAPSALLELFVTWSKRRDLIPFLVDFDQSLLPSLYRVLTVRNVKPAVVLRVFDLVSSINEFAEEDGGRQSSIGQSVIQPGVDVLLEQLGGLISLTASTFDAKGEIAQRQISLLCALAVYVDSQEQATQFLLLAAPLLRKPNKVVSEKIKTDLLKIVTALYPLARPATGTVLYERCCDVVATLFLSARSRSARLQLVAALNSIASVDRSYATVAHLVDELNSFSVKRSEEPDFDRRLAAFSSLNEGMYQTLRPADWIVVLHNMLFFVQDAEELSIRSNASYALRRFVEVSAVAADADLRNTLVRVFMPGIRNVLRSKNELIRSEVLSVLGYAVEKVEGVLELEQLRVLLFDGDEEANFFNNILHIQNHRRTRALRRLADAVEAGAITSKTIADIFLPLIDHFVANGEDKKDPDLVNETVQCFGRLAKHLGWSAYTKVVYQYLNLAKTGGTVQKACLRTLVSVLKSFHFDLAGQPQQLDSTTNRMVPQLLAYLEKRDETDQEVRIPVAEGIAAVIQHIPGDAKYVQETALLMALAQTLRSRDQHVRDLVRSTLVNIVVANGGDILGRAVKELRKALARGPQLHVLAFTVHALLVRLAEAPEGVEFDQALDEVVPVLDADIFGAPSKDRLSQEFRAKTKFREVKSFKSLDSFQILARVISPVRISALLSPLRGIISSTDSAKALRDVEEVFKVLATGLTANTALDAVVTLDLCHSLISQNASFLKSVQKVRRNAKAAPDYHVQLERDVAGERDYYSKNAYRFVSFGLEVFNAAFRKSVFDLDSPEVLSRMEPLVALVGNALYSDDPVVLARSMRATASLIRCPLGTTEQAAPVLVKQMLSVIERSGSTESELAQSALRTLSTVLRDCKTATLSEKQLTTLLELIGPDLEEADRQATLFQVLRAVMARKFVAPEIYDLMNKVAEMLVTNQSGHVREVCRAIYLQFLLDYPQGRGRLRDSLAFLAKNLSYEYESGRLSVLELVSAILQKFAAQLVKESADLFFVALVMVVANDDSTRCREMAGELIKVLFTRVEKETRDVLLAMMSSWAGQKAQPQLSRTAIQLYGVAIEALGPDGRSAAAGVLDILLDVLVDSEQRLEEAERDGDDVEEVERIWQLPYQALQALAHVYRIFPEEVSPDKKEYQALWQAVRGHLLYPHLWVRTSSARLLGSLYAANQAAIANSTLPERHPLATANLLDAAQKSCLQLKSAVLDDGLAMQIVKNLFFAAKCFAARTVVPEADGNEGDESGDEEEQAEKGQEGEAQRSADPLRWLFTRLSFQARQAHTHRPSMYAQDAGQWSRQPATILRWFAAVISFLDAPTLQRFVVQMATPIFRISEDPNAQDPQMAELQTLAREVQDLLQSKIGTTAYSQVHNQIRQKAAMRRQERKQTLAQQAISDPAEDAKRKAKRAELRKAQKKKRTAAFAAQKERFGEGSKRRRTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B129</accession>
    <name>A0A2S5B129_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_6556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B129"/>
    <dbReference type="STRING" id="741276.A0A2S5B129"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="159"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="524" mass="58828" checksum="95E8D8D582CFF2B7" modified="2018-07-18" version="1">MANQPEITVIDDTTRMIAPVLLSGRDRAESTSSGGSDDSIKELPDSRDRPSASWADSGTVMQQPALTYHQGPSVTTIASSDDADLVPYVGYTPAPPVATRKRFRAPQKSTMLDRSVGNPKPWMKGRKTISRDKKSYFTTLFGISLGLAGGIGAILHSALTVGHDKYDLVFADEFEGDSLNQTHWRVEERVGGDESSDFNWFTNHNSYVADGNLWIVPSLTNETLLPTDYALMNSTFLQLGSSCSSPHTADCFIAADVENNQTLVVPPIQSAMISTRDKVAIQYGRVVMRARMPTGVLTFERISDWLWPQISLVPQDDAYGEYPASGLISVFESRGNKAPHRLDQLNNEMICGLHWGPANAPSFDRFYLTQGLYKVYRNFFNEDYYDFGIDWTPTSVTMWVKSRVRIAFRYGFGSGKTFWKLGEFGYSFGNGTLISNPWAGSENQHIAPFDKPFYLRMAVLTGGTDGYWMDNLPNKPWRNTDARPQAMSRFWAWADVWLPTWPSGDKIRERGLAIDRVEVYQRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1U0</accession>
    <name>A0A2S5B1U0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_6162</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1U0"/>
    <dbReference type="STRING" id="741276.A0A2S5B1U0"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="82"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="323"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="486"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY70752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="60507" checksum="20795D31503FAAB9" modified="2018-07-18" version="1" fragment="single">SSFSDRLFRFRVNWRVSILPLALQLQALYRVQKMASDAPVAATLAMEPPLERSTFSSLGVEPFLCKALQAMAIRKPTGVQAACIPPILKDCIGSAQTGSGKTIAFALPILQALARDPHGFFGIVLTPTRELAFQISEQFRVLGAAVNLHSAVIVGGMDMMIQALELKKRPHVLIATPGRLVDLIKSNQGEWSLGKVKFLVLDEADRLLTPTFAPELGFIIDQLPASRQTLLFTATLTEPVLALQNKPQTPGKPKVFTHVSREVVTTPAGLTQKYVFIPSQVREVYLAYLLQHLCDLTGAQPLHAAAPKPDTKSSTKRTTKRAASEEAPPVLPQTILFVPRCGTAALLHSLFSQLPNPIPCTSLHSHLSQAERLRSLQTFRKQAVPLLIATDVGSRGLDIPEVAVVVNWEVPRVPEDYIHRVGRTARAGRKGTAITFVTEGDVDLVKALEDRIGTQLEELELPEEPVLEQLNAVTMAKRMAHMELHSEGFGERQRKNKEKGEAAQGGGSKAQGKSASKGSAKTHRKGSSNQSAQAAGKGGAVVAGGKKAKKSAAPRGGGGAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1W0</accession>
    <name>A0A2S5B1W0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1W0"/>
    <dbReference type="STRING" id="741276.A0A2S5B1W0"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="124"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="191"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="299"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="366"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="686"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="753" mass="79010" checksum="EA3B32E9A2385687" modified="2018-07-18" version="1">MSRIPVPSHHSPAQPSSYSSYPQDSPAMSSRPQSSRSAYSQSGSSYLSTNSTVPSTPPASSDGLAETRKRQSKRDEAIRKKIEGELSRKRPGSKRAGTSGPAGGSSSSGNHRSARPKQGTVSALRPLPALTVPHGMSVSDASQLCAAKRTDCVLVVDEDEHLCGIFTAKDLAFRVVGDGMDPRTTPVSAIMTPNPMVTRDTTSATEALQTMVTRGFRHLPVCNEDGDVVGLLDITKVFHESLEKLEKAYGSSQRLYTALEGAQEQFGGAEAAATNPLLAYVQALRDKMSFPDLGSILDARTTAATVGVKTSVREAAKLMREKRTTAVCVVEGDGKKIAGIFTSKDVVLRVIAAGLDAKTCSVVRVMTPHPDVALPTLSIQDALRKMHDGHYLNLPVIDEAGALIGIVDVLKLTYATLEQVNTLHADAGGAADPAGGPLWGRFFSAAAEAGGVDDDVESVLSGLNSEAASSQAPFHTPSRPGYHRSKDSIDTPGSELFPGDSASVVNADDTSDVGLSHRGGPHASSVGGISQPATIVDDGTYLFKFVAPGGTTHRFQARYDSHEFLIDIVAGKLASDPFFAASGDVTSAVSGTDAEARPDPKDFQISYRDDDGDLVLMTADRDVTDAVQTAKQQGKDRVVLHVTGGSTWKAAIAAAAEKDEKEREKAKAATVTKKLVVVEEEAADVEEGALSGAKSDDAHRRSSKASKKTSAAGSDDLVGGILPKEYLLPASIGFLGVVIATVFIASRASASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2C0</accession>
    <name>A0A2S5B2C0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2C0"/>
    <dbReference type="OrthoDB" id="2529807at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="326" mass="36231" checksum="F6194F8A9858FA7D" modified="2018-07-18" version="1">MALDGELPSIYDQLGPLQAPPVDLHASTRSATDRRHVHQLVQTCEQGTAGTFLHSVLEQSHRDAIRNWRKRSSRTRRGGPAAANDDRAGDTEEGLDHDDDVDDDEELELRERGYVHKRRSTTRTRSASVASIVSAEGDDELGSETEVAHNLTTTDRGGRSHKDKVQTSRRRLRRLRDNLRIPDVQLDDPDLPPDFPSNDLFTALHDRAIQLYSARHNLLPPLTPSEPFLAESDQAHFDAVHARLSAEEERAIRQGSKAIARAWKRTRIQKANAGERRGVWTDASRAFEGSALVALGLLTNLLVENAVASEADRLPDLPPHTPPTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2C1</accession>
    <name>A0A2S5B2C1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_6105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2C1"/>
    <dbReference type="STRING" id="741276.A0A2S5B2C1"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="273"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY70927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="373" mass="40269" checksum="EB4D718C6D5F4E31" modified="2018-07-18" version="1">MATRPTVQVRALQGESSASVPLPAVFTAPIRTDVVAQIHKSVAKNRRQAYAVAENAGHQTSAESWGTGRAVARIPRVGGGGTHRSGQAAFGNMCRGGRMFAPTKVWRKWHVKVSVNQKRFATVSAVAATAVPSLVLARGHRIDGVAEIPLVVSADLESVKKTKEAVAALQTLQAHADVAKVIASKKVRAGRGKSRNRKFRQRRGPLVIYNEDNGLVKAFRNIPGVETANVRSLNLLQLAPGGHLGRFVIWTEGAFAQLDEVYGTYEKPSALKSGYTLPINKITQTDISAVINSQEVQAVLREAGPSKTRKATAQKKNPLKNRAVLFRMNPYAATLKRQAAANEKRAVAGGKKQNHKQAQTLASKEFKETLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2S3</accession>
    <name>A0A2S5B2S3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY70991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2S3"/>
    <dbReference type="STRING" id="741276.A0A2S5B2S3"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF2">
        <property type="entry name" value="INACTIVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="11"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY70991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="366" mass="41655" checksum="9DDC053BD64E510F" modified="2018-07-18" version="1" fragment="single">IYKIGLAATISVWQIVNWLIYSLAAVAFVYRCLDLAAHDDDKQNHYRQLAFQWLSMAAPLVWAKLLTVFDLLRFFGVMQIVVWRMLKESAVFCVLLVIFAIGFGQALTGLDVADEKRDSTRTVINTLIQAVLGSPNFDYYDELESAYPFGLILYYAWSVATIVILLNVLVALFSSAYESEETFLAFFASKTVDSILPLPRAIQRESLHPIDESRLIELVILPLEFIVSKRTYARINRVLMTTLFIIPMFCIAVYESRISPVRRTDLHALVCEPDDYQEAEENPEPASEERDGAKIAKVEFEQLKKRMPDLQRSPVGECLYQILELKKELATMRSELAGMRGDDGEKAQLAKDAKRYGKEAKAELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B455</accession>
    <name>A0A2S5B455_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000080">
        <property type="protein sequence ID" value="POY71564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B455"/>
    <dbReference type="STRING" id="741276.A0A2S5B455"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="112"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="339"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="464"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="881"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="684"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1003"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1022"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1172"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1182" mass="126028" checksum="27373FF9EFD24A54" modified="2018-07-18" version="1">MLASPRAREPLRFAESSQGDGNDDGQPEPRLAAEATEPVASTSAGTSNVAQEHPAAVEQPIQPPLNLKQQQHPPSSHPHPPPPPSYSLWRDGVSYAHAPDLTHYLESTFVPSVVPQPDEYHAKDQARQYLEKLADQVSPGAKLLPFGSMANGFALKNSDMDLCCFLAKDAPVREPSELVEILGRLIEQETNFYVKMLPRARIPIIKLTIPPSTDVPMGMACDIGFENRLALENTRLLLTYAMIDSRLRTLVLFLKVWTKRRKINNPYRGTLSSYGYVLLVIQFLAHVKQPPVLPNLQRLSSPDGSAAEETMFDGHDISFFDDLDALPSLFQTTNTETSGELLIDFFRYFSKEFNFTHQVVSIRSDKGVLPKLQKGWHVDFEFDPELTVRDQHKLCVEDPFQLDYNVARTVTRDGLYTIRGEFMRAFRILTTPTRSPEGIGAVINSLCEEREDYLLIHPADDPTAHYNHRLYPGSPAHPQQRSPRRRSAPSPRMGPTAYGQALHHQPPHLGQSPVLGREHPFWNSMNGGSPIMNGGGEHSAPRLGPAPVEGGGGADQAGGKAGGALAEPFHPGGQASHQPHPGRPPHPISEYPYGGRPPIQHASTPPTVAGSPPPPSASLEVASSSSSRERRQSWDGTSAGKAGSSTSGTTLNGGYDLHRFFQNPQQQPSSSSVSEVGGPTSTSMAAVTSTGSTLNGRGTVSLTAPSSPDMMSQSAYFAGHPTSHYAYPYSGRSQHRHGPSGPTGPYQAGAHVGPRLATSVPRNPHTAHHAYTNPYASAPVPYPPTGPPAPGGSGYVTPNGYPLVGAASPVPAAAAALAALPPPPAPIFPEEDRQTVAMANNITFGSFPEMLPLPSYAQYHASGGSAAYLAGGGGWAPEPYGVSGPMRSGNRTHGPGGGPRRPIPRHSLSSTAENEHSGEEDNEEDGTFPTDSATNGPTVRSTYRHPFPPLLGKDAPLSRDDDDESDRAPRVRGRSAPHVRLGPDGRETLLFGAIEVTLPRAEDVEEAEQEEVEREQEDDTASEASSPGTGTASIDSAEDEVAFLGPTPSSTEGGSEPVAATTDQIPPHAVRSIPVLTTQPPTPAKALGSPPRNALGLDEESSAQDSPSRPSRSGSRAASPRRSLEKSASPSSTSSQPATEGNSVHAEAPAAPHEHEDDLVNGISSLSFEPSSTPPSPASPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2019-12-11" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4A0</accession>
    <name>A0A2S5B4A0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000076">
        <property type="protein sequence ID" value="POY71586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="12" mass="1211" checksum="034FE37CFE6DDDD0" modified="2018-07-18" version="1">MVPPIAAPATDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4P9</accession>
    <name>A0A2S5B4P9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4P9"/>
    <dbReference type="STRING" id="741276.A0A2S5B4P9"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="260" mass="28087" checksum="F8F5647F2FFF8289" modified="2018-07-18" version="1">MRPTPPSWLKLLVPVKRTVDYAVKIRVGPKGVETKGVKHSMNPFDEIAIEEAVRLREKDKKAIEKITVVSIGPAKASEVLRTALAMGADEAIHIETAEDDVVEPLAVARTLKEIVGREQPDIVIMGKQAIDDDSSQVGGMLAGMLSWPQANFASKVDLDVAAKTVTVSREIDGGLETLKMSLPAVITTDLRLNQPRYASLPNIMKAKKKPLQKLKPSDLGADFAPRLESVNVEAPPARQGGAKVESVDEVVSKMKEAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Q3</accession>
    <name>A0A2S5B4Q3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Q3"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Q3"/>
    <dbReference type="OrthoDB" id="2536616at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="82728" checksum="FBDBCBF88C9AAE43" modified="2018-07-18" version="1">MSTSAAFVETSSNAVGGATEFVKPVLDIDTSVSRTSTCRRSSARPRTPPLSPSPRSWSGTDRLSALSTTMTDLSDFSPSPTASIASVRIATLTRVPPRSHGRHRSLGMESILSDVSNSEVVCDDALPEKEGTDNHQDDSGGDSTLLASRARAPLAPAASGLLPSVEGLPSPQRSKAVRRSLDAELLISRSLGPETRVVSPPPWLSSGDENDAAAPVLASQRRGLTTSRSLDLLGRSTTHGRVDTSPRTVLDFPDASKRPLSTHERSASTAPRPRTTSLDLLRRTPASGSGASSHVPGVLASAWPASTTAPASASLLKGSLSAPTSSATPDVGAAGLQAYAEARRAGHASRVAGAVDVVEYLQNGPRATRAAVPRSTEPTPLNDQTAPTAGAPASTLLFARRGVAHSESKISLAYSTAASSESATASPSTPAGLGVFDKSPAPSLEDTSYFTAVPGAPVVGAFGHRLISLEEARARESERLAAARRKAASTPPLSAPVDPREPSGGWPSSRGIASVETLSSRRGMTAPSSLPTTSSSTSLNAAPLTVKPKRSGFLRRMMGAGSSSEKQRETVTSPDSSRPSMSPSVNTVCLSPTLSLAPGHPGSSHSRAELFAESPRISIRGTPERQESLPAPFGTSVSPTLSLRPVSAVFSAGLPPDFLADPLTATALPTSPTLSINGPTSSSLSRSPTLSLSPPIGTCTRGEDAPLWSKTSTSSLSPYVWANTPGDSSWTHASGTTTSLQASTSRSSPETVPLERYLALQDDFNRARSAWLARQLDLEARVKELQARLAQRDNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4R6</accession>
    <name>A0A2S5B4R6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4R6"/>
    <dbReference type="STRING" id="741276.A0A2S5B4R6"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015422569" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY71767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="214" mass="24468" checksum="DB616DE8A2018B80" modified="2018-07-18" version="1">MRLALVFATALAFAQSTSALYFYLGAGEKRCFIEEIPKDTIVVGHYKAEEFQESSKSWIINDQLGIQIVVTEVEDGDTIVNTRGLPAGKFTFTSHGAGDHTICLQSNYTGGWFSTPQIRMHLDVAVGEAKVDEEGEREHVKDLAAKVRDLNHRLADIRREQQFQREREAEFRVLSERTNSRAVWWSVIQLTVLGATCVWQLRHLRHFFESKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B591</accession>
    <name>A0A2S5B591_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle tethering protein Uso1/P115-like head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY71954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B591"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="421"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="6">
        <location>
            <begin position="760"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="840"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1382"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="852"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1099"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1153"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1183"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1252"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1274"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1315"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1329"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1503"/>
            <end position="1515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1569" mass="167827" checksum="16C99B40FFC38E47" modified="2018-07-18" version="1">MFSTLRAGYNSLQASTQPQSATSTIDKLCDRLLNSQQREDRRAALLAIKGLSRDWKSEVGSQALPILLGVLEDDAAEDTEMAKAVVETLSLLCEVEEVDGRPVRDDSGLRNSDAFLATPTPLHTLLTLLTPSHFYLRFFTLQLLGILLANRPQQVQQYVLTAAGGIGKLVETLSDSREIIRNESLLLLIALTTQNADIQKLMAFEGAFDKLFGIVRSEGGIGAGGIVVQDCLAAVAGLLRWNVSNQNYFRETTCIPMLAPLLLFPRPNALTPQSLATFAFQSWSEQKVINAGLVISVVRMLVGGAGGSGRSQNQEALLKTGLTRCLIEMALASNAPAILKAQSLNALADIMRSSSENQATLTSLIITPLIPPAAPSSAELYNEEYGAENGEQSRNSVDGGRSDNGLEPERAASLRWQRGESVPAVVAVTNLAVNGDGTPGREGLRVRAAAANLFTSYVAGSTETQLGVLSTMLAPPPDAEHTMSSGSVILDALRTFPSSSRSDTFDSYVPFFACLLFSHLIMHSEVCKEVARKIYFQGDDTSPGGMGDEDDRITLVGVLVGNLMMAQREQAQSVNAGLGPERVLEWSRIMVGYLTSLCVWMWESPNTVKEFLSEGSNLQVLIQPITQSSGVDSVVQGLCTYLLGVCYEYNREPGPISRETLHPILQSRVGPDQFVSRILRLREDPRFRNVGPNVLELIDEDDALAEDLGEENGLWFDFSFVEFLKTNYISVQRSILVDPHASTAMAQSMSSISPDVLAALRASLAAQTAELDELRDTVRSLQQEREQERAAVETEFASMSDTILSLRQQLEAAQAEKAEADREQEDLLVLLDDLNVKRSKDKRRMRAAQLEVSEDEDGGDAVDDEDEVPLERAASQSTEADAPSHPTETPTADDVQGQEDQQIDRPASPERASPEEPAIPPPDEPSSPHDQQTSEGDVDAEDPYRPRQSVETQPSTIEEAPIFEMHDPYLPPQPDVSETSRASEFADNDPYNPFRAEASPSSASQHEAEPARFEAASSLFDAPSAGRLDDLFAPTADYEPSKASSSALKRSDVDAEEVVAEASEDLTTAAQPSERASVPIGAASVASLPTATSDEEPSRDEQVSRDGQADGTAATAVANVEDTSERPATPQSEPPPTTSQHATSVLRATPRRPPREREGRELIEPHVVDEEDFRPKSAAGIAAPPPPPPRASGPAPPPRSSVAPPPRASAKGAPRRAFFAEPGMSAQIASPKQHFPAIASTSFESGEAIFQSSSPKSPSSSARSRGAKDDETVSGLSEPSLFSPQSLSAASSLDPAHQSPPPKSTSVSPADDTGANAQQREQPSAPTESEPRRTSIDDRLTTAFFGGEGSHDNDSVSSLFGGPTKDVSSLFGGAFQAASRTAGSLFGSTPRDEPEPRASFDSQRSGQRMREASATEKVPANARGAVGRSEERTASSLFGGGNAPTASALFGSREAETSDPPAASRPQPESEPAVVAEATSPQTAPLPQPSRARPESQDVSTLFGGGAASLFGGAGDVPPEKPIRNARSPFEAPPNSNPYESAHSFFASHQREPSKPVQSGVRDVSSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5M6</accession>
    <name>A0A2S5B5M6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000060">
        <property type="protein sequence ID" value="POY72056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5M6"/>
    <dbReference type="STRING" id="741276.A0A2S5B5M6"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="10">
        <location>
            <begin position="146"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="313"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="181"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="476" mass="52881" checksum="7FAF1BFC34985F8C" modified="2018-07-18" version="1">MADPQAESSTPPPATATTTDTSTESTAAPLEIKGSATGARAQSQDDEEAATTATAMVAGTPSPPPLPAADDAATLDARPATPPPSAAARGAQRGTRRPAPTDDDDDHHRAGENDDTAMVDESNAEEEARLRAEKKRKVLEDQKLAQRKRGNRMFGMMLGTLQRAQKEVKLVETSGAGKKRLELQERLREKLDAERKDAMDKAERERELRELRTEVARREDEIAAADALYRARHNAKLDLAGFLCTTFTPGPVPPAPNANDPISVPFQPRLPHAMKLTDPRAPRPIYYLPYRLLPSQEDRIDDQIAAVKAAVRKDRDEWEKSKDAKLEELDKVKRRRTERLEEVEREERAERQRKRRATEGAADGAPPTRGGRGDDDGDDIDSRMRSRSPGPQQRAAARSRSRSRSRSTSPAPAATRRRSTTSPDARRRNDDDDVSPKEDRRERSPKAMQVDNQDADDRESTRRRSDSATAQVEVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5Q2</accession>
    <name>A0A2S5B5Q2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4893</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000059">
        <property type="protein sequence ID" value="POY72086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B5Q2"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="KP78A-RELATED"/>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="565"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="121"/>
            <end position="419"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="443"/>
            <end position="510"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1037"/>
            <end position="1355"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1377"/>
            <end position="1608"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="164"/>
            <end position="175"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="203"/>
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            <begin position="248"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <begin position="265"/>
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    </feature>
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            <begin position="302"/>
            <end position="313"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72086.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
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            <dbReference type="Proteomes" id="UP000237144"/>
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    </evidence>
    <sequence length="1626" mass="170495" checksum="18F771E28FFF4BE2" modified="2018-07-18" version="1">MPATPTPPPPSLPPLAFPPGLGPASSAKRAGSGSASPAGSAKFGPATTTTTTTTATSPPHSPRLLAALAGASSGSSGEVSPASSAKSSGSGRGRRLTGAGGNVQARRSVMSLGLGAEYANMNELTAPHSPANSAPGSRERAPSAGGDPKSPTMQYSTVLGGPTNVASPTLSSASIPTGGGGGGGSTSRRASVQFADAVPPSALNASTSGTAGTNHARRPSVTHLASFLAGVQHHTRVRSPGPSGGRGVSRSASRSASRASSVRRLSVRRRRRRSASGESAGVADGGDDSDEDAPRRRRSSDSDEDDSDEADDGEWNRSGSGAFYYDDDQPEPKEFNWFSSTAAAAGPGHGLGPASSWFRSPSLQQRRPPSMSSRASSVHSTRSSRRNSVSTTGPTSPHPALHELVRENTTGGVAPTDPIAVTTPSVATAAVGSGNVWEATNETYKPSVLTTPRMRRATSPSSAAGNDNGEEPFLESEPNSPSTRLTRTKTYDSYVSSRVDSSSVLGDDDQPMSDLANVDVFDEGERVGVGVWLEGRGGYVRDCFAGRVDRDGKAPGNGLDGPKQLEVERRLGEGTYAIVYLVREVLHDPDPTLDDDDDDVLSPIDPLASFEFDDDGSRPRLHSWASDTWTPPPKPTYGQYYALKCLCKKNLTEDLIEVQRNEAFLHRALPKHDNIVQMYGAYETDDWLFLVLEYAGGRDAFYWLLEAQEHGTEDLYSRAASPAGDFDGDFDDSALSRTITADTPAHLLVDETPPSPSLLSAAMGDQLLSRKRLRLISRMFGQMCAAVQACHDVGISHRDIKPENFIVIDGKDDRGAKSASDSTDSAKQGGVVVKITDWGLGTMQEYCDDFDCGSKPYMAYECRNNLRPSYDPRQADVWSLGLVFLNLLYHRNPWADPSLDDPDFAEYVDDPIGFMQNRFEGMSDEVAHYLANNVFCDVLEIVDGKQRRRVSAGDFGRWASRLVTMMGEGQLGPGERPQVTSSDSYSAFEFSPVTSMPVTIAGGPPSASLLSQFAPSTVKAHSSMFDDMASDMRSELPTVPEVPDMSFTSSTPIRPSYISSPTALSEDGDSLPSPTFPSPAMAPGRVSNHTSPNGIARPLPWSSPPRPAAAQLPSPPATAQPNGAASPPSLSPGGGSPLIPPVPASGISLLAARRPTLLDTQADSTMSTGSTVMAPSGPVSPSLEEHVPPSAIEPSAAVGAGRHDNGSPPNEQDEIEDGAKTPGDKEKAGKSKRRKRGARKEKRAARQAERETGVASGSGAASPLASPRSGKLPTVDESRAHDHVLEDLAAASQELARELSSTRSGSSHRSSRPRPVPSSRALGTQSTSAIPTLAHEPPMPGSSKRGGGGMFGRLKTLVNEGNSDLEAFKRRVDERNSAIGAKADTYSAPAQMQGGRVPRGKYDSPFSSHGSIGTASWGSVQEGDDESRGRAHDHWSSASSRRDRLADRRGQRPSAATAVVPGGTDFSPSGSSSTRGNPSSTFESSASRINTPLSSFGSVGSPMASSSVTMRDWRSPAPTVGGGDKTGSTSRGRKDAAAPVRPKLRDASTDTSDLAKKSLGPPAEVQPQRAASASPAIPPVPSASTTPASPPPPSQSPAPGPAAKTNKLSKMFGSISVFNRTAQSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5V7</accession>
    <name>A0A2S5B5V7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000059">
        <property type="protein sequence ID" value="POY72091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="741276.A0A2S5B5V7"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="384"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="697"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="807" mass="89852" checksum="F2156214B8ED2DAC" modified="2018-07-18" version="1">METIVLESDSSSDESRAARRRGRSRKERIKAGKRKRVEPNTDDDDDDDDQILIVESFKTRRRRPNANAASGSNNASQDMIDRKGKRRRTRSPARHDADLMIAQLSAHLDEGQHALDDDTFNHFLQAFAATTEGHDSDEPGFDDPDDVDQDDANQAGVQIDDPLGAMLAKVLLVVPDVLPLHAHDLLAANLDRGTGAVDYVVGILLEEGTYPKVDEQQAAANEPEEEDWLDVEARMRNGDKPTPHYKQHALDHLLNACRHLPVNLIKSEFAKTGSYSAPTLYALTTRDQAGEFAAKKMKRGRKATNPRKRLVWVDTVDEYGQPARKMQEEPDEVPPRLAQEKRWIEAKITREHAERIAKQRAEEREARAAARVDRLNQRAKQRGEAIECGCCFDEVAIENTAQCADGHLFCKTCAAANADNRIGQRQPVSTTVRVLHTMCDRPLTRRHLPADAPLHGARMLGDVPPRHVLGLLKPNTIDTLAELAQQKDLEAAFEGVDEFEKCPFCPFACYIENKDERLFHCRRPDCGKVSCRQCKLDNHIPLSCEESAKAKSLSSVHAVEEAMTAALIKHCPKCKVPTLKQDGCNKMTCSDCRIFWCHRCGKQIAGYDHFAQDKNDTTRCPTFDDTAVREHAAIEAARLQAQADLDGVAREAAEKLAEAAPVRNAPVLQQGIALVQNIWNGGQPRAQVAANRRAAARQQEQQQLAAIQQQAAAIQQQAAAIQQQHQQWQAQHLAAQQVYAHHLAAQGAQQAHAEQLAYQAQARAQQLAYQAQAQARAQAQAQAMAQRQDGFARVFGVFDNVRAHFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B657</accession>
    <name>A0A2S5B657_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glyoxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000052">
        <property type="protein sequence ID" value="POY72268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B657"/>
    <dbReference type="STRING" id="741276.A0A2S5B657"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="57"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="123"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38072" checksum="FED9327306446FF8" modified="2018-07-18" version="1">MAPKIILTRPLPAEKGLEGGALLDQAERAGLVRVVRWTKDEPVDRKWLLEELGKGDTDGLLCMHNGEKIDEELLEAAGSSLKVVSTMSAGYDHVDVSALKKRNIRFGTTPDALTDATADIGAMLALMATRRAGEGIRAVLDGKWPEMPWNPLLLCGHGLQNTTVGVIGFGKIGQTTLKRLLGFGIKRCLYSTSRVGAPLDSSRDYFKTLPLADYLGIEVRPAESYDEIARESDLVVLCCPLTPQTKHLVDAEFLSKVKPTACVVNTARGPVIDTDALVAAIREGRLASAGLDVVTGEPDIPADHPLVKEERIVLVPHIGSATIQARSGMSRDAARNCLAGVGVEGFEWANEVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6C4</accession>
    <name>A0A2S5B6C4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6C4"/>
    <dbReference type="OrthoDB" id="2529676at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="192" mass="20681" checksum="D334452ECF38C617" modified="2018-07-18" version="1">MSSRGSPIPKELEDGPANPFLPFVPPLAALRTRIARRRPTLPHTTASAPTHFPSIPFGEIGRENDDDFDVMSVLSGGVSDLDVDAESAAFQPRVRNLQTRRPIVRRRMTADVAAAGTREVGDPRVQTAKRSEGTSQDASEQTRSDAPLPAKGTAVASPPEEADEPRELVVRVSQTQQWDPSVDDGQVSGPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6K8</accession>
    <name>A0A2S5B6K8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.70</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_4246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.70" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6K8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6K8"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="4">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="259" mass="26887" checksum="8B4DF1DFD8D41511" modified="2018-07-18" version="1">MIVGSSARLLTNAGRTASRPACAACQSSAALSVQTRSAHKLVQVQLTTDIPSLGSRGSIVITSPGRARNQLVPSGLALYVGRDGKPVSAARDMNAKATERMQGYLMGGSKARRDSERDRRAKAVLEGLAGGVVEDPLAPARAADRALAQSLGSLPPSALTFTRLTTSPTSHDLFGSVSVSDVITVLRDSGVVAAVQAGGTGLTEANCYFDEAQDGVVRGRVKQTGVFKFVVDLKAVQEKKVVRIEVVREEAAAKSAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6M9</accession>
    <name>A0A2S5B6M9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4256</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6M9"/>
    <dbReference type="STRING" id="741276.A0A2S5B6M9"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="131"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="230" mass="25714" checksum="28075F9AF6B21B5E" modified="2018-07-18" version="1">MDTSVFAEYETDLQTLQASISSRLEGDAVRLRGDERQSTFRRIERELEEADEIIEQMAVEAQTADRDKADLQAKLRAHRNALAQRKAELKTLISGADRGDLLGSKHVALDIEDDDRSGSPALSQSAAQRSRLLNATDKLADGQRRLEESHRVALQTEDVGSTILRDLRGQRDVLEHTRDTLYEADGSIDRASGTLRKMVRRAYQQRAITYAIIGLLVLLILYVLASKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B702</accession>
    <name>A0A2S5B702_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative Histidinol dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4337</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="12"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B702"/>
    <dbReference type="STRING" id="741276.A0A2S5B702"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42945">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42945:SF1">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="11">
        <location>
            <begin position="235"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="434" mass="46531" checksum="B5CAAF442C3AE712" modified="2018-07-18" version="1">MSISQLAFLPLLDSEPSSLATETLPALARIAPLLVPSSLAASALTQLPPTADHYILDDTDLSLDEAIRYLDKGARRIASRNKTFLASVPAERFILRCSRDDLSLLSNAQVVSSISGVLYEVSEPNADELAQVRTALKAVSGRPRDLFLIPDSLDAALRLPVSLKSLGKSAVSSIAVVPTSYMSTEMPSDFASPSLLPDKLPIASLFTSCLRSDRTDGLFVTIPVSLSSVTTPLGLVYSSAESIAHSILSGNAVYYSRSRNGLWRKGETSGAMQRVERIRFDCDADALEFGVVECGPQGEKEGFCHVPEQTSCFGGVGGLAELEATLKKRMAEAPAGSYTKRLFDEPLLLRAKIMEEAGEVCDATTAEELASEVADLLYFTMTRAVANGVSLKDVQAVLDKRSLKVTRRKGDAKPEWVEKLGLGVDQAKGVDGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7F0</accession>
    <name>A0A2S5B7F0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B7F0"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="740"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="996"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1538" mass="166786" checksum="D09E31EB30272526" modified="2018-07-18" version="1">MGKQKPTPPAPPPAPNAAAAQAASSSKPPPRRKANIVKSGNAGSSKPAPPPLAPGEAPPPPPLFRKCLSSVGYKTPLSLLTERCQKAGWDRPSVDPKKGSEPNAWTASVTLRRKNPKSGEPESVYMRPPPPPSPIAVEKPSAMEAKHWAAVYALFRFSNNLRLNLQLPPSTRGESSVMYFYVELWLWSTTPFETAAAAPPPPQPQAATAGTNGNNSAPRATGSSAGSSRAGTPSGRPLVAVANGAGGAHGARPTTAVPKHWLEAPEVRMPTALRDLVERTIRDSLPDLSDADLLAGNAEGGAQGSTYGGHDDHADSPMSGSGAATPAYLTTGPSPDERAVEQEFLAQGFRKGHVLRALAYVRSASSGTSDPLPLPTLRHEVLSHLHLLVPESDLPAAFQSSKPSDTTIRNATARDRDELGRIWRAEKIAREVGTPVEWVSAEMERIRQASEGDAAVETEGELEGRLLELLARRMMDVESLADEEDGEVRAKLGEDSLFRRWSDPSLYDLDVEAKTELKQRREDELVGLEGMLGARYHRRKDGFDIAIPSSGKTDPVALRVLFHPSSRYPSPDDGTSSQPAALPSFYVTSPTLPPYIRLHLAYLLASSFVPSSPVSTNGGAWLELVDGGYGGVVGEMVAFLEEHARSVIDNPPDARTVMARLLPLSERPDATLASQVSQKITKAANGNARNGRRSRKLRATPAEQLALKQSYEALQQTPGYGKMLAQRQGLPAWGMREQIVDLIRKSRVTIVCGETGSGKTTQVPAFVLEDAILRSEGATTSIVVTQPRRVSAIGVASRVAQERCEDLSPSSSPGTDNLVGYAIRGERRAGRGCRALFCTTGVVLARLGRGGDPDLDGVSHIFIDEVHERSVDSDFLLLELRDILVRNPDIKVILMSATINQRQFSDYFGGAPVIEIPGFTHPVQDFYLESYLPALLANNAYRPSGKPARKATQAQLDRMRSSFIERGVSETDIRALQALEVASRAEKIDFGLVGATVAHCLASSVEAGGDILVFSTGVLEIKQSIEAIRAAVPSHQLSSLLILPLHANLTSQEQTSVFRPTPTGKRKIVVATNVAETSITIDGIIYVVDCGRVKENQFDPETGITRLVECWTSRAGCRQRRGRAGRTRPGICYKLFTQYTDENTMSAQPTPEIQRTPLEALLLQIKSTRPTADVRDYLGRALDPPDVKAIESAWATLGMLGAIQDTGQDQAGLSARLTPLGSHLAMIPVDVRLAKMLVLAAIFRCLDPILTVVALMSSKPFFLNPMEQRDEAKKARATFYTGRSDLLTDAAAFEACMAARKDGASSFRTFADDSFISHSTFRDVLSLRSEYLQALSAVGFIPLRASANDPAFNENSQNEALLKSIIFAGTGRLVRVKLPKAVYDRTISGSIERDREAREVRYFEPDGRVFPHPVSLLFEETKYTSPFVTFFNKQVTTKPFLRDVNEVPLFALLLFSSGRIAMELDRGVTVHHGVLNARQAVHLRAWPRIGVLVNGLRKLFDQDLERELEEPGFGGPVSAAVQCMLELLSPRDAIGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7H4</accession>
    <name>A0A2S5B7H4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7H4"/>
    <dbReference type="STRING" id="741276.A0A2S5B7H4"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="373"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="680" mass="70700" checksum="78F028A871247C0A" modified="2018-07-18" version="1">MSRPASLPAIAPRPGPGPTPGGTSSSSYSGTANKAGHSPSSVSNPGPPPGASTSAMQQHPVASTSTAYVPALDSTPASASSSARATPVPGAGTGGSGSAPPTKRKRRNKVDSACRFCRKSHMQCSGERPCARCIKREIAHLCTDAPAPAPTPTPGAATSTGGNTQPGEAIVPKAESPSAPLGQAGGNVPGYSGLGDGNSMINTLGLDFQSNRPHSGSPHFGQQQQHQRRLSQSHSQQPFVGRSSASPGTATTTAAAMTNAPTSTSQQFAQLLAAGSNEQQQQQGSPYHSASNNLQGLGSAASPGTAGGSAAPHGAGLYASEFNMAMLDLANDGLGSMFGLETSSLSSNGDGEFRGLGLSEFLASLDAPMFGSNPGALGASSESQQQQNTLASTLANASAAGPRGAGADSTSNLVINTNDTGLNESNEGAKDKAQAGKRSFGPSVPGSPVNKTERFLLTAADQKDGSRSDRLAKVIHAKFEAGLLRPYNHVAGYTRLMKWMADNMSANSRQRTLHTLSEFRPTFRAIASGLTDLDLVFIEEAFERLLLDYDRVFSSMGIPSCLWRRTGEIYKGNKEFAALVGVPIEDLQGGKLAIYELMAEESAVNYWEKYGNIAFDVGQKAVLTSCVLINQSILSRKRKKAGADKRKVPEDAMVNACFSFTIRRDSYGIPSMIVGNFIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7L9</accession>
    <name>A0A2S5B7L9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7L9"/>
    <dbReference type="STRING" id="741276.A0A2S5B7L9"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="166" mass="17792" checksum="A5FEDD553775709B" modified="2018-07-18" version="1">MLGLKATMSIIDNSGALVAECVNVLKQKTGHGMAGIGSLQLPPREKRNHARASRVLTLGTRRNAGDEIVVVIKRARPQPQSTQQSSSAAGGGAPKVRKGDVRHAVVVRTKYPTRRPDGRYVRFDDNAAVLVNNKKEMIGNRIGGVVAAELRARGWGKIVSLAPKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B821</accession>
    <name>A0A2S5B821_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B821"/>
    <dbReference type="STRING" id="741276.A0A2S5B821"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049546">
        <property type="entry name" value="WDR54_beta_prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21031">
        <property type="entry name" value="WDR54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WD repeat-containing protein 54 beta-propeller" evidence="8">
        <location>
            <begin position="98"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="562" mass="57959" checksum="976004A2106EFBED" modified="2018-07-18" version="1">MATHTAPALSELVLSSTHAASPLPTISLHNPLTGALVYSFRSPVASTSTGPNGAARNGVTDKDQPSLEHRTTFAAVEGSHGCGGYLVGLGGKEGRAGMHVWNFTRETTQHRLIPPVRLTTMTVSRDGAYMAGGTPDGRIFLWEVSSGTLIVTIDAHYRSVSTLAFSDDGACLVSGSEDAGVSVWAMGRLLNASPMNPPAPFATLADHTLPVTDVCVGLGTFPQCRIMTASLDSTVKIWDISTTPASLLSTFSFPHPVSHIAWDALERHFFAAGPTLPSSANAAASTSTAEASSSSSSVGGSRVVRVNLFRRRKDEFGFDVTEPVGGGGRGEVERVGGEGQSQSQGQEGETYEISETITSLHLSSHSPTLLVGLANSAIHLLSLPSLLPTRVLTPPPSSTSPGPITFLTTLLRPPELGSSNADLPQRVVMPQGMGRTVVGPDDRERGGPKGRIVEMRIGAAGSATAAAFGLSGVGSVEDLISPVQGVPSLLAQLSAAGNGAFGGAAAAAGGAGAGAGAAALDKERKRAHDLERQVEALQRDLGRAASVNEAMWKKVVDSALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8B9</accession>
    <name>A0A2S5B8B9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_3862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8B9"/>
    <dbReference type="STRING" id="741276.A0A2S5B8B9"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015640144" evidence="7">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY73024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="111" mass="11732" checksum="A676A3F1C8665868" modified="2018-07-18" version="1">MFGRILVALSSLALLHSVYAAWSARTTAKYAGIALERRLGTQVPTEVAVEAIASFVLLVIGILWTAPPLKGVTFASEMSNRTVDTADAGLGLANLRHRGAILFAPEPVKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8C5</accession>
    <name>A0A2S5B8C5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8C5"/>
    <dbReference type="STRING" id="741276.A0A2S5B8C5"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="393" mass="40446" checksum="5FEB7A9FCA28DEA5" modified="2018-07-18" version="1">MFIGGLNWDTTDDTLKMYFEQFGEVTHCTIMRDAETGRSRGFGFLTFKDPASVNAVMAREHHLDGKNIDPKRAIPRTDTAKTDKLFVRSLPPSCTQESFRSFWRQFGTITDATLMMDKETGRHRGFGFVNYERREDVDKVLQSGPHYMDGAMLEVKRAQAKNEPRRPDYGHQGHHGGSSYTPQPLGGMGAMGGMGGMGGMGAMGGMGGGFGAAPMAGGAGAPAGGTPFDPAAMSKFFTQMGWGGWNPQMMMGNPMMMGNPMMGGMGGMGGMGAMGGMGNFGGMGGMNMGAMGGGAAGSPAGGSAGGQDDASNAGSSSNAGVSQWTAPMAQPMGMQGGRGGGMGMRGGRGGPPTGPASMRDGGRDGGRDGGRDGGGAGPQRSRGGGSGYHPYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8G2</accession>
    <name>A0A2S5B8G2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_3901</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8G2"/>
    <dbReference type="STRING" id="741276.A0A2S5B8G2"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015598422" evidence="12">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="258" mass="27847" checksum="0A1B1C71852ECE37" modified="2018-07-18" version="1">MAMLSLVTLFLLAASMCAPALAHMLKRPAQRHESMYGVGPGFTSVAGDPFSPIGPDIAKQDNWWFRGPGYRALKPQNDSVMSLPVGGTVELEIACNAAWTSYGDRTTDPDAELSACPENYGAYHSGDPTGPVDQSLLSGCALAVADKDDIEQVGWDDLVVFSVNHECVKQRVTQFERREVHLRLACKQRNSAYNEPTNVVWQGNDNRPGYHASWSFPKNGAQDDIFDTSHASSALDSTGGTSTGLSALPDTFVHLKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8J9</accession>
    <name>A0A2S5B8J9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_3923</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8J9"/>
    <dbReference type="STRING" id="741276.A0A2S5B8J9"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="244"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY73085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="351" mass="36866" checksum="2298AD6A152CAC22" modified="2018-07-18" version="1">MSAPPLPSDRAQLVASAVSFLVDPQTGSSPLAQRIAFLESKGLSQNEIQVALQQASQQQGGAVQPRAYGGTGNGGAAGPIMYGRPGGQQGGFEYQRDWRDWFVMAVVGGGVGWLAVKLAQKFLVPHLQPPTETDLEASQKALEAKYDEAAELLKTLQESTDAVAQSLDEQRAEIDKELEEVRDAVREMREGEKKRDEWAKNIGRQVDEMAKSLPGLLDKQASAQSSSLTDLQTELRSLKSLLIARRPTPTQQSSSSSISNPTGNGGTLSTSVSSPSLPFAIKPPGLPAWQLKGSASSSSLSTAASGSATPTAAPTDSTTLENKDPSASGVLVEKPVEDQQATAADGPAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8K3</accession>
    <name>A0A2S5B8K3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3848</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000041">
        <property type="protein sequence ID" value="POY73110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B8K3"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="58"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="414"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1364"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1452"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1462"/>
            <end position="1481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1866" mass="203101" checksum="F02D36DF9DB75FFF" modified="2018-07-18" version="1">MLPTAIRPGSPQLAVTSATATAASSSSPASPHLVPSQPDDALARSEAVQSQERAAANDPKYRKYAAAVDKTLATFEHVNEWADFITFLAKLLKCLQSAPQYPFIPHKLTVAKRLSQCLNPALPTGVHQRALDVYTHILTTIGPDNLRRDLPAWTSGLLPFFQYAATSIKPMVLSILDRFYLPLHDALRPATKAFILALLPGLDEETGEWFEQVAALLDRLCDTVTPSFFLSTLWLVVITAPRSRVAAINYLSRRLPLLAPPEAAGSPAEQSDRQLGLMVRAFAAALVDDQILVQRGVLDLLINTLPVHSAAYQNLPQADRTFLARASLGVVLRRDLSLTRRLYTWLLGRSDGSDEQIEYFRSHALRDVHAALACDMDAAASLSGDLEPPPGSNVAAMPTAAQKAPHLPASPTSSATLLRPFKIFISLLDKWELGAPLTAVVVIDTFAAIRSILSPTNGADVNEEVFHTAQLLYEAFDPSVLWRAVYDIAHRALQHEEASAGTIAQLALVRYMVSTFRIRDGEAKALHAPLIAVTILRAATRRLETTSTLSGLVACVELAHDLIVEVPPPAATETATASSRTETGPAINAAEAAERVYAGTSIAQEATMASLSSPNLLSEGLDAALDLVASSCRMHSKASHPSNSRPTASKTICLLATRLARRLIGMPHLAARSYSRLARSPESAWSVSSWICDVTCAVECVKAVPGNFELHDALIRSVLDLHAAGELYSAAQRIELSKVFCAKLLDYLAANAAQCHLTAVELIWAVDSLSPLRTIETVISSRLAHPDKLVCARGYEEFGNLWRFTPDQHLPGKLLRLPMFAILDGLKSDSLTERRLAEAWMRCSLKSYLRVLDPIFYVLTDPTLRIETHLAILGEIRVPVSHYARPIDHAQVQHALDSLLSLARFGGQGFIRVAKTSFLKHTLDPALRQHILNTELETCTYLDGLVVLLLRFLCAEPASTSDIRPSGTQVHALTAEILQVLLSRGEAELSDIPTIEAALSSRLFTSICRGEVDLQNKMLHVLHTVVHARSQPVESTRGSARQPRADTPAPPPPAAATPPFEASQSQSQYEPPDLSRDDFFLRIVTSALKQGDNAVVHHWLDFLLMTVPHSHYDTVAVLGPLLDVLISRLGRCIDEIELAFAAVVTEAEASATDAEFAAIVNALERLLLLYLPKADREATMSLGNGTIQRNGGDHATASGPAALLGYVTGVLGQADADLDGASSSATRDTRRLTDAVEVLLLAWDCSLRLETSAPCVFDEAREHVVTRVRVRARRALDRLIKSNTAGIADAVVHVWTEWQSAARPTLVNASRPEANLPGMLHALFPSPATLVPTLYESVPIKHSSTKTTTSATGNATEGESPLAFLAWYLGHVEPASIVQLWTPTLQFVRDVVTHQAHNRSLLYPTLRCFVTVADKLAKTRALEDRRLRRDLQDTLSRLIDVTVQTAARTPESSGWLRKAARESSNNGDDASISNETDASSITEKDRSNGGEAPRGVGTSEIASYLASSVLPLLDSLQLEPDKIVALCTNISYYVIAPAVKARSQHSEIQPAVYKLLTQMTLHAAAGKVWKGTVSDGFSDHRFFQASPSAHRHWQPLVHALMTADRDRLPELVARISTSSSANIFTNRELEVLSRALALRRVTYTLLCSPKDTFLTQLPAIQEKLVDLLRSPVGDLVQAEVYLCLRVLFCRIDNQHLAGLWPVILTELLRLFDSLLDRSVSDGSDFLQLVSAACKFLDLTLVLQTEDFQIHEWIFVTDTVDAACMTDSMPQAVIDRLGARAGPGADTVLADVARLGQHGGPARRPLLTARRISSMSTLQPFLRRVSHAAYDSIYEAGTKIDWPAVEGSLVADLFEGPSSDSAGGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8L8</accession>
    <name>A0A2S5B8L8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8L8"/>
    <dbReference type="STRING" id="741276.A0A2S5B8L8"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="8">
        <location>
            <begin position="131"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="443"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1031"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1124"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1199"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1051"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1124"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1164"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1221" mass="136258" checksum="1D0726D02FACADFB" modified="2018-07-18" version="1">MPQAAPIKRVNQRTATDGPGRALERSTRLNDQYAHAVQNKAFTFAGAGLVGLLSINTLVVSWNVRVILSLFVAASLAYFLRQALDTAAKDFAWYDSEQRRAELAHPPLADLEKDRHAGASDLPKDGTAATEYEGAEWLNALMDVMWPVLDQQLFATAQDLIEDELKALTPSVVVRPFTDERADFLPDHQQTVRVTSLEQGVHPVRILGMRILPSSAKHSSFVPEPVPDGNANRNDCDHTETYSSWTDPSIPEPAPFAADQDEQRAGAEQLLEEDEDGAQGPYVEMEVDFGYRRAMSTQDADGSDEAQGKVAPEDVDQHIHFVAYLNIGIHKVTGFPVPILFAVQSIRGKARVRLQFIPEPPFVKTVTFALEGFPQVEVNAYPLRGPLDVLSVPFIKQYGQSAIEAAMAKFVRPRHYALDVRKFMFGGDVPMSEWAQVVADENSCGHTLTRISLAETRTIGLVVVVLHSAAHLPAADPRLSTIRNRGGKSDPYVEVSWSALGKSLYRTRVKRDTPEGGEARWEEMCFIRCPREPIEDNSKYVRSPQMHRVLKLLTKTFSRKSLRFSVWDDDRFRENELEPFSHQSREPAHLTLVGFAEVPIRTIHEKPGEWRRETARLNINERDVEHHRASRDADGQIVPATLEYSIAFFPLLERARQAEAEKEAPTQKPADDPARHPLAPEAVNERAFESDKLHEDRKTARLDSLKEILNGRHPPTPGHRSGILSFMVHSVADIQLEKGAGAVKAAMRRLKPGTQTKAMRKAELPSAYVMSLWNDQLIHRTRLAPVSTSLHGSSQEQRQSLTFCVLACSPTPNFSGGSETFIRDWTLANMTFAVMDYRDRDRDVLIGYASLDLRNVFRDHCQVSKWYPISGGAGSGRLRLSMLFKPLAIHVHRSEYGRCSQPSAQMLILESLPQGLREWSVGTLQVVSASVIGLGERNFTGVLRLKIDGGRSATRSVVDRQKDDDSDRLEFDFSSGPILLPVLSRITPVQVALMGMGMSSTTSGRKALAEGVFTLNKVMRDTPEQTIEIILDRNGPPPMPSPYPLPRLQIEDDNDSDEQEDSLLKMPPQKTEVRSDRRDDSLVLRLSARWRPGMSSTHADLVLSEGSSARAAYEVYLHKRDHEASLAAERSADEPRSTEEENGRGDAAASEPADGAGWEDELDERGHVDEIEDKKDGTRMRKGGTLRWLKHGARVAGRRIQGIKHHRLGELQPETEMQSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8M9</accession>
    <name>A0A2S5B8M9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8M9"/>
    <dbReference type="STRING" id="741276.A0A2S5B8M9"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="387" mass="41584" checksum="DC74E93699E51122" modified="2018-07-18" version="1">MPVLVAIGCSSSLGSLALQRFLATAAHPIRWRIYANYRAEGKPTFPGSESCTWLPCNLESLQDVKSFAKQIRAKERAVDVLLLNAATWDTTAREVKVGGERWTREAVVNHLAQHYLVHLLADRLQASGEDGSLERARIVMTTSNLHKSVASLADLSSLLRRPSTISSTDPAAEATSTAASDLAASSASAPTRQTSGRERYSASKAAQLLSAHYWRRVFSVKEGTNAAPSADETARSSPRAVDIVAVSPGFVPSTNLSRDSNWIARLLMRYVLSWAPFAVSSDEGAGRIARCLPPYEAASNVGNSEATATADPLATLFASLPPSDILYISQSSSTPLDSAADAEGSSRYRVEGGAVGEWFKAGANWEEVQRILGSAIPTRKEMDSWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8R3</accession>
    <name>A0A2S5B8R3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8R3"/>
    <dbReference type="STRING" id="741276.A0A2S5B8R3"/>
    <dbReference type="OrthoDB" id="3253876at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="426" mass="44395" checksum="F5BC88197DFE3DAF" modified="2018-07-18" version="1">MPSNNNPFAPSPPTEVSQAAHRFPDVLNQDPDLQLRHQQQPYGLQAGYGQQSQGIGGGMMMGGQYGQPQGQGMGGYGGGGGGGGGGLVPQQTGYGYSSPSPVPGFQQPQYTGYQMYGGGGGGGGGGQPQSQQPYQSDLDPYSSLGSSSFAATSNQSSGPNYQQQQQGGGGTLLAVQQTQSHPRDYVHENKAQLMVWDEYAWKQLFSRNASRTLASNAMASSQALREAWESRLASLRAASNSGADPTSVLSLKRDAEDKVDSIHASKMQLDEVKTGWRHSTDTASKARVREALNAGLSSLPSYPSPVHPSQLGGSFNHQLAKDSIMSQYGGAGGQQQQQQPQQGYMQSQQTGFGYGGMQGGQMQMGMGMQPQMTGYGGSGMGMGMGMQPQMTGFGGGAAMPQQQQHQQMTGFGGGAGGGYGGGGGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8S4</accession>
    <name>A0A2S5B8S4_9BASI</name>
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        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BMF94_3814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
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            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
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            <taxon>Rhodotorula</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000040">
        <property type="protein sequence ID" value="POY73121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8S4"/>
    <dbReference type="STRING" id="741276.A0A2S5B8S4"/>
    <dbReference type="OrthoDB" id="2527720at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="79"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="265"/>
        </location>
    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="778"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="82031" checksum="EA22F6EE21B5E43A" modified="2018-07-18" version="1">MPDLHSRDGTPDDSIEAGPSGQSAAAASRKRGRKQDDSLPPSRSRDIQRAFRARRAALLSNLELRVAFLERENSALRDQLGLAPDGPPLSGPEPEYQRVDGIAEGIEGTSSERPGVAVIAGSPVPSGNGSGTTTKRPRKRQSSGKPAIERDDAADEATSNGPPAPNSLYGNAPSPLATLAHAAGTAEWHDPHHPQAGSPAPHPNGPGGAPPPYMHYPYAASPNGHPMYQSSPNESGPPHPGHLYSGQPPYPPQHTQPNQQHPVPNGSVASGPRPHGWSTSAQDPNAQDQQGAPYTQQYSHPHPPAPAAYSLPHSHPQQHSQYGYPLANQYPQHAQAYGVTTQACCAQPHGASPAGSVPPPPAPMHGQYGYPPPPPSHAPPPSQHGQYAASSSHGHQPQPPYGSGFSSEASPSHTHSGHVTLPPTPVSHTPSPASAATSPAATGSAAAANGRSALGPSAMHTSSHGQPQLPPHQAQQQQQLSLGPSGSSQLYLQQPGHAGSGSTAFTASPAGSAASPLSTTTTVATPQTPLSSTGNVPGSTTATATPNLVAPREYLLRACGLSPRTVSRALAAGVGDADDEHRFAAFCAAVVEIAQRQPGPMKRIKLPRTDSSSSAGSQRQADGATGPADTAGGDKNSLEWNDELCCGGLIDCSAPIFDNTPSYPTPNGSSSVSTTSGRPDDASSPAALPTLPPFLPLRDAFSRLSHALRKAPIELALALSSLGGSAAAATADRTRPDSSFAVVSVPGNREDGIKGTEELWVAEKAVEAAIEADLAAKSDSNSSNRPAQAETCQPKSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8T2</accession>
    <name>A0A2S5B8T2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8T2"/>
    <dbReference type="STRING" id="741276.A0A2S5B8T2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6533" checksum="9C457DD98DC2A096" modified="2018-07-18" version="1">MARGNQRDKAQKKAADANKGKRSDGDGKSFRTKMENDAEIMRKKQEAAAAKKAAEAAAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8U0</accession>
    <name>A0A2S5B8U0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8U0"/>
    <dbReference type="STRING" id="741276.A0A2S5B8U0"/>
    <dbReference type="OrthoDB" id="2528653at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="894" mass="98214" checksum="B5AE94AF3D39A813" modified="2018-07-18" version="1">MASAVARQTRPRLDSLVLPFLAPRLLVQSTAPPTLAKSRQSTRTASTQAQTKKAAAPEEAWIHGTSWHERWNEREQPVASTSAVRLDAVLVRSRQSGSKARTAPSPALSAAAPAAAIPPLCPSLDDAQSQTVKALVAELEPVLARLRSAYLASPTSTPLELVKSTLAAIQSSSDPRARHSHVPPIPPPLIRLDPEPHAGPKSRLWTPFVLQALFLGASALGLLARRKVAHNTLGEDGHPAANAAGGTGGRATRAAQKARQAAEDRIDEVQALNLLVVALAQPGGILVPERSSRSTGQDPRRKWRDELDAVKGLAALLQQVEAARLPYDRATVLVCLHSVSHNGTDQPDMPIEAVEARRKVGLWAWRARRGLTSADRTVVDKEQQDADGAITRSFLAVLYPTFQAADRHFFPKSPSSTITDRTILNALADEILAPEQSASTSLLRALAETAWRARRVDILGRIATRTAAPVSSPAELSLTLFSTARALEILAMDVRRRREADLVLPWAIAFRDAVVRVVRERQAPVGRTDLGDIRAGLECLLNERSFAINRPLEPVIRDTCLGLLDDHATTAGLAERRLIARVMRRLVASRHPVCAVRILNAIPAHLITLKHYRPLLASSHLPSAMRAWTSLRVHERLRPDAACVRAVLASLAKAPERVSLSFAFRLFRRLVEPTTRDWNLLLRIVARNGSDKLLQRVTREMQDAGRQADSRTAAVFVSREMTRMDTQRRSAPTKHDGPRLVVEQPRRVSGSAQVRKVRRAAREWDSKLGSDTPSPNAPHDILPNLLLKNAVRWPRDYDVPKLVVLTRSRLGVDLDQADSTLSAGPLYSGDREAGTHTGARARSYFEQVRRPAFRTLSKGFEQRGRADLARRLRAALKQEEEATRRMQNMSPACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8V9</accession>
    <name>A0A2S5B8V9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8V9"/>
    <dbReference type="STRING" id="741276.A0A2S5B8V9"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29333" checksum="DC3F01129C086EBD" modified="2018-07-18" version="1">MPSKLSLSPFALPSPGLAHFNRVAGSQSGQDKLFMVYQYAAYVAVAALTSKRFGNKARADLALRIEKLRATISDARTLYRLFGLFPIIAWAQSLNDPATQPKDKQHLLINKLQAWSMMAYYPLEHLYYLAGKGVFKISPARIGKIAVWSCRFWAAYVVLQIFHIRRSFQLLGEERTRVVRAARERVRTGSATSDELQREKADLQRLAAQEKSLKNDCWVQAGYLPLTAHWSLPGGLLPNNAWVGVCGTVAAVAGLNGVWKRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B900</accession>
    <name>A0A2S5B900_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B900"/>
    <dbReference type="STRING" id="741276.A0A2S5B900"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="709"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="954" mass="103620" checksum="55BF22966BE169D5" modified="2018-07-18" version="1">MPPGQRAYNHAARKRTATLPKSIRQELEQLGQLEPQNQAKSRLGRNDRRKAERNQPKQNRAQHQGGPTPTAAGANKKRTAADALERERAPVASTSTATTGAEVQQPAKKRAKTTGDEVETAIASTAATTRAEAPAAPKMTALEKRLAKQERGVGPDPARKRSKGETDDDKEIAWLEAKLGLPRGLTKAEKGKMKAEYDEDGLGDLFEGLDDLEGAAFGASKKNYTDLLREMDPDDLPSDFDFDALEAGSEGGSASEGDLVSDEDEGDSDDEAFGEYGVSDDELVDPSDDDDHDEMGEMGSEDSELDEAGMLRESDLDSGDSDPEGDSAEEEEKPTAAAPAKPVAGSYVPPHLRKKVADAETTPANSATPPPGKPARSAPSLEAPPEDPRLRRQINGQLNKLSQSNMSAIVDQLLSIYASNPRAVVSTTMISLLLGIISDRDNLGDQLVVTYAVLVAALFRTVGIEFPAGVIARAVELFDAAFKKHTEALENGTDPTDAGDVGFEGRPGSKECLNLVSFISELYNLQVVHCGLVYDFVRLLIESGLGELQVELLSRIVKRCGQQLRTDDPSALKDIIALVKQKMQGVDPATMNSRTRFMVEQLTNLRNNKLKQPGADGSLDLYTGPRKYLVGLNKKRATGAAPDPLRASLDEIRSSTTRGKWWLVGAAWAGDPLAEEGDASGPALQFQSKETQGDKQLAKVARAQGMNTDVRKGIFNVIMTSEDYVDACDRLLQLGLSDVQQREIARVILQCCGNEKVYNPYYTLVAQRLCVKSHSFQITLQYLLWDFFRDLGEKSVGGEELVKSMENSRDTDGGSSVSPRRIANLAKLYAWCISREALSVAILKPVPFSSTQEQTTSFLVQLFVFGLIATQTTSPALVLPTAATRKDREAVERMFVKAATSPKLQRGLGYFFEAHGKDIVQWAARKLGEREKAVVKWAVKVAAETLSVDGIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9C3</accession>
    <name>A0A2S5B9C3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9C3"/>
    <dbReference type="STRING" id="741276.A0A2S5B9C3"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="61"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="873"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="765"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="781"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="930" mass="99540" checksum="BFD08A3AA92158EC" modified="2018-07-18" version="1">MQGGAHQARSASHGRHRSTSASGGASGAYLPPTDTSPDLYDFVNAFWTDGQSSRNNRGRDPDDVELDWGKNGYDTVMGRVKAGAKVCDDLRALLKERASAADDYAKRLGKLSKHHFGTGETGHMERAMLQLKSELESSAKSQQDFAQLLRMQEGMLGDFTGKRDSARKTQHTAVEKLWKNLINQRQHVLKAKSKYQDDAIQINALHAQASLLQGRDLDKATIKLDKAQQTVMVNERDYRNYVTVLKETTVNWNMAWKSYCDLVQDQEEERLEFLKSRMWDYANGLSTLAMNEDESAERTRTALEQVDPKTDIRIFVQQYGTGNAIPDPIPFVDVAAKEPPPKQTYKLARFTRSSTRIPGVKHSPSAIGDIAKAMGQMPAPVRQQSLPPSEPMRSQSQPDAGDYREPARPSSRAADRSSMPAFDSHVPPMVSSPTKMTAEPSRGVQSAPADANASTRFPISPSANGRTRPSAEPAAASPSSRPGHITAGAFQNRQISPSLGGSTPPAGALRQGSQPSRNNLSASVNGPGAAAGDDDDENDPLVKALRVLQSTPIQASPRARSSVDLRNSAAAQGQPQSTQRPSSHATQHSFGSTRSRPGSPEKQQAAQQAPSQTAKPRARTPSYPQPQSQPQYQARPASRAGSSVPTEPVAATQSNRYSTSAAHLASPPPASQYSARPPSPSRGVQSSTQQPFIPPSLRPSSPLPGANPARSSSPAAQTPVAAQNPAPYGTSPSQIAYASPPPPQNVYGTSTGPAPQSPYGYSTGAPPPQAQAVQGPPPTAAPYRAVSPAARPASVVAPPMGYNGMQQQQQPYMAQAPSQHFQPAPSPHQQQPSPHAAYQSPSPVTYAPPAAQSPYAQMQFPGPSSTYTETGQPILFYVNALFDYAAASAEEFSFSTGDVIAVTATDPDGWWQGNRVGDSGPSKLFPSKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9K8</accession>
    <name>A0A2S5B9K8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9K8"/>
    <dbReference type="STRING" id="741276.A0A2S5B9K8"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001136">
        <property type="term" value="P:negative regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="623"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="895" mass="97145" checksum="9963EED06811972D" modified="2018-07-18" version="1">MDRTRSGSRATSDDDNPASYFARPDLTLAPVPPRAQDSEPGSLSQDATFDLPHRGKKKRAASLSRLFGHIGGEIRHDIAGMQQRRSASHSRSRTRSSEVGVAAFDSLRRSGSPPEEDGFESESPQNSAPHGLFSREARRQSRERQQQQQATISSPRSPSFSRRRADSAPAFPRSPTWRDDPGTSPARHRESTWGAWEGPDGALTDLRDSLPRPKNSAVSTTTSNKKLPQTSATQTGAETPDTSASRPHVFTPRTSSALDNPVTESISPAGPPQQSLFKATFSPRQLARLQRASKQVERHDRKIANKGMVGAEFKVALGLFDVLNKEKKEQKRARGQGKAGGGALEGERHGSAGLAGLAHQLEQQVEHRLGGVEHDLRESGHRFEEGHGNRASVALGVGGGAAALVGLVGAGYEMWQQERKRREEGHEQAVVGSLSGRQRKDSVAKEARGASRPAFVREMNLSPDTQISTVKDCAKTASGVRPPSAAPLRDHEFSLPHLPASLMPRAVPPHPTTPYLSSLTPAQHHLVQHAAAALLLKDHTHGNLHEKLHRAVGGFDKMVQLLEVGMEKAWTGVSEHAGTGIGSNRGGGGGAARRPKSAFHFRHALDLGFRLSSVASRAELFGTPLPVVTHHEGVDSFHGADPHGTVRIPEFIDHCITALMQADVTVEGILRKNGKVRLVREIMEALDSNGGNDAVIDLAALDPVTLADLFKRFLAALPDPVLTSHLFKLFVACSHIHNVNMRRRCMHLVLCLMPKVVRGSFGESVVGFRVGARSRLSDQQNRDVLEVVFLFLEWLSQYAHITVKDGNQMNLTAIATVMAPTLLRPTHRDPKPTEINAMIAAILSLLEDQHFLHAVPLELARVLHLHAPPQKKDVEGKKKGLEGGAALLHALAKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9L7</accession>
    <name>A0A2S5B9L7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B9L7"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="793"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="976"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1374" mass="139562" checksum="7C6514D915E84285" modified="2018-07-18" version="1">MDSPAGRTVAGGRRTATSTDSPARHGTAAAATAVAQRQLGSIGGRTGPGYSPYARRVASRQAQFDHPPPKVEQQQESPGADEEPRQSTGLFGKVRSLPGRMFGYLSRSSSKQQGLSTSSSLADVRAELDQVRDEPATLQRSKTSNNLVRQAVTRGAPGAILPPPIPSSSSMSALSSLGGGGRTLRSAHSKLNLAPSTVERGVSHGPGSVSSYSRQNRSPSPLRNGLAGSMSTFQLARYGQEPPTLGDGAVSNPFGLQSQSPFAASRTYGGTSSSRSTRSASQGHPLFPYSSNLPRGTSPALSGSFSMRDGLSSIAAGSATKRTFTTRAASPLARSGHVLPGGLGSSKTVSGGLSNLVAGDYDGGDDVEMLSEDLTGAERARKKQLVWDPERGLVSREKLEEDRAAPPLPKNEAERILEVLEGMGRTPMGDAKRGSIRPKHISIPSLADEDRQASRLARSSTTPSFLFSSTPYAARSARPTASPPTNMPLKPEKGLQAVLRAREERRRALLEQERAERERERLEDEERERERERKRRERRRRMEELMSDDDHDAMSTGDVFSDEPVSPRRVTRSSARQQQQTPAKSRGTKVNATNGKGKGKGKEHLEPPETTTRRSTRASSRPKSPSPAPPPTRNTRKQSQRDDETDHEDEQPKRAANKSPSPAKSPSPAPVPESIEKPPKIAFPAPSSFPATAPSTSTGRSSLRPGKSHTSRQHTTSSRVFSAKEEDLPPIDDAALAKIQMPAFKVPSGFSFGAPAAKADEPKKDMPATTAAPATTSITPAAPTPSLLSRLGAPAPAAAEPAKPAFSFGAATAATEAAAPPKPPAFSFGAAATPIAEKDAPPKAPAASSDFSAKPAASTAPSFSFGTSDSAAKPNFFGSIIADKDKDKAKEAPAKTPSFSFGATTEKDVIEPTEIIPPTPTSTATEKPAANPFAAFGKPVAEIVKEAAEGKKPEPSFSFGATPAPDAGPKKDEPAAKAPFAFGAKSDIAPAPAPAPAPFAFGAASKPSTESSTETKAASPFSFGAPAAPAKSAAPTFTFGTTPATPTADEKKEAAPLFGGGGLNAPSAPASVTDEAGDSGMEDEADPEPAAAPSAPAFSFGATPAAPAAASASSFGSTGFTFGSPEKKADPPASPFGAPASTSFFGGGGGASPSKPPAFTFGASASPSPAPPSPAPASGAATPSFSFGAATHSAPSFSFGGPSAAPAASGAPSFSFGAATPSTAPASPAPSTGGFTFGAAAPASTAMGQSLSTASTAGSTTGAAPPNFTFGGSAPAAGASTPTSGGFTFGSSAPATGAIGGPAGASPFTFGAPASQPGTPGAAPGGFAFGAPSANGATTPGATTPGGGLFNIGTGGGDDSNKGRPIRPLRRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9Q4</accession>
    <name>A0A2S5B9Q4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_3426</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds ubiquitin and polyubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9Q4"/>
    <dbReference type="STRING" id="741276.A0A2S5B9Q4"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="11">
        <location>
            <begin position="421"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="333"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="461" mass="49092" checksum="215583DCB7119199" modified="2018-07-18" version="1">MVHLTVATEDGSTFPIDVDLSMELENVMALLEADSNIPVDDQLLFFNGRHLTDLKESLESYGVQANDMLLLRQKSTDPNANAPVAGRNVEQDAETMRRQVIGDPRLMGELRRANPDLADAALNNPARFRELLHQLQSMQESARLQREREMALLQADPFDVEAQQKIEEAIRHERVLENMEQAMESMPESFGQVHMLYVNVEVNGVPVKAFVDSGAQSTIMSPSCAERCGIMRLIDTRFAGMARGVGTGKILGRVHSAQLKMADLFLQCSFTILESRDVDLLFGLDMLKRHQCSIDLRKDALIIQDRELPFLPEHEVPRFGQEEFELDAQGNPVPVGSAASSLGSAVASGSNAPSGSSSGTATGFPGSGRTLGSTPASAAPQPKRARSGSPSASASTNPTPTSIPPSSAGGAATTAGGLPTGVTEDSIASLVGLGADRATAIRLLEAAGGNTEVAASLLFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA16</accession>
    <name>A0A2S5BA16_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3146</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA16"/>
    <dbReference type="STRING" id="741276.A0A2S5BA16"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="248"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="707"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="885"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="650"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="908"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="964"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="997"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1015"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1048"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1198" mass="127816" checksum="11DAC738DE9C3C5B" modified="2018-07-18" version="1">MAGALTVICAYVVGGLTFVPLCLVAFCFFLYRTSPVVALPARTSGASASTADKDGDEAEPVTVYRAGWLSARKTYEPSKDNGDGTYLGTLASSYKSFMDNRSKDPRRTRPKDRFYAVLKQKTLYLYEGEDQIECWAAIEVAAYDVLIYPEDYVDGELFAKRTAIQLRPKSETAVDSLLDSASDKLDSQHTPWFFFARVNSDKEDWYHSLQLSSRFGSPSAAADVARDRSLFDSEDMARLVEAIDQQPEAIPMRWLNALLGRVFLAVYRTKSVEEYITSRIVRKLKRVKLPTMLSEIQVREVQVGSSAPLFSKPMLKELTADGDASLEMHVAYVGNARVTIETEATISLGSRFKPYTVRLVLAIVLKELEGTMLLKVKKPPSNRIWFGFTTPPKMVLSVEPVVSTRQIKWSMVTGPIESRIRELVMEAVVLPHMDDLSFFNTAACPLSRGGIYGDFLRDPEPSPEEELNGPKRDDREVTNEDIPEEELVGEEATTSALAPSLSAKADGLRPTAAMRRRRSSEGDHPDKSAPAVGPLAGDAGRKKSNSSAKSVSSLAGLGASFAQWREQTKNASAPGDTSTPASTSAKSAEGGSQRKSTWFGNGNSNKTANAGLGSNSASASAPDLFTRTPSVLSLASTDTTSSVHPPAQVVEDRARDDISAAKLKDILSKRAASRERERQREREVERARELEADAVIARVGRVDTVQASAAGSSDGGLDPVRIAGSNATPRLTDSPEAVTSELHHSDASEVHVVPSTHDTDTLSLSSAAGSARSAEHTHALETDTITNPPALPMRPSWVRSHSPVRDAASVMSTVSPPAAVQPLPAPPPSHPRHAVSASVDDAGSITASSSTSNLLSSWRTRASDKEALAAGVASAKESMRRWGANWAAKRAAKDSPRSEDFDNVVGESPEKGRDGSADRYREHRRERDSSTAAGSAGYFGDIDAHVTKPLPLAPDTPPRGRAGSLSSSSLLSTSPSSARLVPAASTPSLALSPSTAVGRSSPSTSPQKPSMMHNASSSLSATTSYAGGYGATTGSTYGRRTMAVPGIRNEDLKKKVAEDHLGSNATSPPQPVLGDLARTSSIERREDPPSTARVSPTEEPASSQTSANLGPDGTLSGELSDPAETERPALPAREPSATGLAVSSSEQPAMARSPPPLPVRADAQSTPAADRPPLPARPETTLPIQQEVAEGSSRSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAE6</accession>
    <name>A0A2S5BAE6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3282</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAE6"/>
    <dbReference type="STRING" id="741276.A0A2S5BAE6"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="114"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="227"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34198" checksum="BAF85950B0424A40" modified="2018-07-18" version="1">MEVEEAPPVVADPPARSYVEPWVVVASSASAVSARLFTHPLDTIRIRIQTAGHPVPPIRELVPTPRLASLYAGLPVAIGFSVPALSVYLATYEASKRYFSEHFLPRDREVGILQQLPVFVAAGTAAELASGAIWTPLDVLKSRLQTGREGTSAIALTKKIVREEGWMGLMRGYWVGTAIFIPNISVYWSVYESLKSRYIPGYSATSSSSSRPSTPAPEPTTPPGTIPLTLRYTLCSVTACVIAATTTTPIEIVQARWQTSGGKIEGGLTEIVKTMWRTGGPMAFTRGLGIRIAYAIPANGISMTMYESVKRWKGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAG6</accession>
    <name>A0A2S5BAG6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine synthase I TruA alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAG6"/>
    <dbReference type="STRING" id="741276.A0A2S5BAG6"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="6">
        <location>
            <begin position="317"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="625"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="672" mass="74544" checksum="024BA74707F41713" modified="2018-07-18" version="1">MAAQLATKPDRARLLAQLRNVEAQLAKLDLEEQQQHEQPKPVAAAATKVQDVKLNKRARKALARQGETGPLPPSLASAPKRHIALLFSYEGWAHSGLAYQPKGVYTPLPTVEGCLLAALEKARLIEPIEEGEGFGCGFERCGRTDAGVSSSAQVVNLWVRSDLEDPMQVNGREIDPESVEGRRHARSRSRSRSRSPSSSDADSEPGQPTRAKKRNDVEIPYVTLLNKHLPPSIRIHAWSPVSATFSSRYSCIWRHYKYFFSTSPSSALLATRFDFGAAYQALDHGRYPEHATSDWRERLAGIDWHGLELDVDLMRDAVQRLVGEHDFRNFCKVDPPKQLPIHVRTVLSATIDPLEGEGDDMFVLNLRGGAFLYNQVRHIVAILFLVGARLEPPSIVDRLLWTSDRTPHTVATSAFSPPSSASADSSPTESDAPAVEVLDRKPGYQMASDLPLILWQCGFNSHEFTWRIDNVPLVGDVNADVLSYIDHNGRERQPVDRNETFRKQYLEMRETFLEAKLKSIALKHHLASFAFLAPTLPECDDPTSSNNDTSNARYTPLGAGHHLRSTSYIPLLKRQRAELPEVLNARWAAGRGKARMARREETRERCDREREANLKIREAAFELAEAANKRLQQEGGEGKSSDETRGRSPVGPAGSVGGTGATGTDTPIKGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAQ1</accession>
    <name>A0A2S5BAQ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_3025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAQ1"/>
    <dbReference type="STRING" id="741276.A0A2S5BAQ1"/>
    <dbReference type="OrthoDB" id="2530377at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015647084" evidence="3">
        <location>
            <begin position="24"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY73855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="316" mass="32460" checksum="4A62638B58E4009E" modified="2018-07-18" version="1">MLRPAVLPRFIILLGIAAHHVRAGENMSITAPTSIEPNAQVTIKWAGGQSTYTVRILVNSHSVQETRSVAGPTFVWTAQGVKNGDEVQFWIYDSSGTNTKSPQIPVEKAGPSSLHKSHKAGNYSTDGRPDKTGSETRSSSSSSPLTQPGANPHSSSRTLDTGRIPTAPPPSPTDSAEPAGSHSVTAASAAESAAVTAKLDGASPFVAAEDAETTSAPVPVSATAVTPSALGAAGLDTPNSAGASNDKTSLYLGLGGILVALVLLLTLVSYVMERDLYVSPLSSFKADMADPDAAVAIFRASIIAWRSNLSGSAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAV0</accession>
    <name>A0A2S5BAV0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAV0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="24" mass="2767" checksum="219BB28208AA752F" modified="2018-07-18" version="1">MPRNRSGLLQELEVYMHQLQPGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBB9</accession>
    <name>A0A2S5BBB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBB9"/>
    <dbReference type="OrthoDB" id="2525845at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="915" mass="98685" checksum="A918E8F08D656160" modified="2018-07-18" version="1">MLSAAARPASRRLGVACTACSCRTASTSSSSNSQRPRSGLPSRSHERPTASQRRHQATFAQAHDTVQRQEHHHHDEQDHDQLAADSAGQRLHSEEADEQNRSADAMAELLDALAEESAGATAAAPSSSLAPMSSASDPAPSTSSAKPTPLPPVTPTPRKPAAITLEDILNPKQNSAPEVADLRAFRPRRFTVPEASSPDSHRLVYRKTWDRAYAAVDRAFKKRQLQDFAGEDGLNVDLTDARLRTRIPGKKPKHWKSKRLDQMSKRELIHTILVLDFDMTHPDTIPTPSKGAQILDSIPLNDRALFLLLSPKSPTIPKLVRHLGVTVAYRRNPESGIVSLILRGNSAGVQAAKAEIEALDETCSTTQFDLPAPATTLRPEVYQAISRQSKTFLEPGSEPTKLRASAVQPKGLERTERHLNAAFAADATRKSTALFASIPSNLDTLRYALFPHHPLQPTSAILTGGTSQFARLKSLSIAPSASAVDDPAHRAQVELLEWTERMRIERTTRTALYVPVGTSPSLKESSILQALRAPFEAVRERDGANLLEAKQVEIVARFGHVAWPLYRSTSSSAGATEGAGGVGLGPSFAGQRSFERVADWISSATEKVKSIFLPSPPTGLLAATDVLKPLPNPTATPFSSLFAPLSGTPEAASAEQARLEDVAAGPTIESTVFRRWTFRPTQLPGREDAQVAERVEVVFELPDTGGIPHVREMDVQRSEVRLIKENKVDVMVPTGSHDAQFAMSATSVLEPEEYPLEFDIKTLTFHAPVPNRIRLSGRDYLFETDQFVRRTAISPPPPAKPASAPASDAPAPLVQERWHSLTRDGARGVDVYQPVATGLAGEIRRTGVWRTALEEVERRCAATATGLTAAGIAGGSGGADGKTPAAMLDAARGPAPAAEGSRLFARISRAPSSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBD4</accession>
    <name>A0A2S5BBD4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBD4"/>
    <dbReference type="STRING" id="741276.A0A2S5BBD4"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="282" mass="31461" checksum="4D1C4DD1464D2910" modified="2018-07-18" version="1">MRPIRILGLPGHAQSAEYLRGRLAKHLEIWGPEFELVALDPVEPMSPATIIGDGHRSETTVASNFRWWDWTSHRRFKPGELERALLHFRNAWEAEGPFDVIFGFSQGAAFAVLVLALLEDPNLHPIWSRPSPRADIEWPPRPVRCAVLCSAYGPGDPAYQRWFDAKRPTTPTLHLLGRNDPVLDSVHALDTAARFEHAELHWHTGGHYIPRKPYWAALMREFMVRHCGVRAPPAQLSFAELSSPTESAASSAGESGGSFFPLTSMSSLTEIAAEAEGEWEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBP2</accession>
    <name>A0A2S5BBP2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBP2"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF7">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39140" checksum="B13886102576E205" modified="2018-07-18" version="1">MPHAIPPNVSHDTPELDCLDFSGKTTYGDFRDDLVRDGYVVVKHAISAERAGYYVDEIQTWLESFNLGYKRDDPSTVRDECLPIIIAKGLVQAYGAPHESFTWGVRSEPGVIGTFEKIFQTDDLLVSFDAVNVSLAGRLDKKYDEFQPWAHQDQDPERPGFRCIQGFVNLCPNGDNDGGLMVLKGGHLVSQEYHKEFNEEEREFRWTNEMYLFKDTGLKWLADKGLEWVKVNAGPGDLVLWDSRAPHYNVPPRGDQNRFVVYTSYAPASTATKEDLLQKKWLFENTKGHSHWAQGFQPFVEAFVGPKRNGQPDPINTWKPRKPPVLSERAFRLTGIPYINEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC65</accession>
    <name>A0A2S5BC65_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC65"/>
    <dbReference type="STRING" id="741276.A0A2S5BC65"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF2">
        <property type="entry name" value="OS05G0199100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein LEA-2 subgroup" evidence="7">
        <location>
            <begin position="224"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="437" mass="47986" checksum="9839D739D25BD9AB" modified="2018-07-18" version="1">MAYYGQHQGGDYPRQNMYTDQHRPYADPPSPAAPEEEYDSPDQYYHQATAAYPNNNYHGEQYAYEPEYHNNDGYSANDFVSPERDGRGVPGGRQTTYPPASSDPDLLDKEGAFAYEKPTVPVTRGSIAAQLAAEGQIPKKEGLRMFRKDEHAGALTRGGRVRCCGRVFCCSVMLIILILVAIVAAFFLWVKPPDVRFRGINPPTSGNEVTLQNQGFLLNVTLDINVINPNFFGAHFSRVDATAYYPTKPNDAVGGGSLTNFDIKKHSNSTINFPFTINYTTSYDSDLSVLQDIAKRCGFLGGAEQQLKVNYKVKTEVRVIAVSIGPSFSSSATFDCPLTESDITGFLGSSGLSGLLNGLTGGSSSSSSSSSRKRRSLSLDPTPEERRAVHLATRHALAKLVERGNQAVPRAEKMFTADRWMRVGTVRRPELVHSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC98</accession>
    <name>A0A2S5BC98_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2599</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC98"/>
    <dbReference type="STRING" id="741276.A0A2S5BC98"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051775">
        <property type="entry name" value="Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323">
        <property type="entry name" value="CEH-10 HOMEODOMAIN-CONTAINING HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323:SF7">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="89"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="725" mass="76091" checksum="C9B38328AB35CC13" modified="2018-07-18" version="1">MHRAFTTPAPNSRFPTTAAAFEHLTTKEEAREPELPTPNDRPLAGHETRPSGSSSPLRAALTSSVFASQYAAQIYSSGTREDPLIPKRRRRTTPAELAILENEFRLKPRPDPIERAHLAERLGMTVRAVQVWYQNRRQKEKREISCSSSITSTGSDPKDLDGVILSFSSSPLPSPVLPLQPSTGPTGRAGFFGAATEGAKAPQASNALPALALAASGRLVMQPTVSAGDKENVRSPAEPRAPQLLTPVSSSIQPYRYSYPSQPANGTSSTGHPSSSGASADAPHSTLNVFVHRPHNSSIIAAKKHVRKRPLGSHAPLARTPSLPHSFAFPPSPPRSVQPPSARPGLQRSASYSLNTVAVREQRKSAAGLFANSQGETVACAADRRRSTSASPTGGVSQGLGPARPVDESQSLTRQQLAAVKAAVPVPMAMMTPVSKARARDELLQHMQSDPPTTSSPGPIPLTRRRVEALERSHAVKAGEESDDEHLAPLSRMMTAPVRPQVARSVSSPNTRVGGLPTLSAFGPSTELRGTARSMLQTPAHARSVSVPARPAADVVAVGSSSPAPTAFGPSAMQAGADLGNCAVKVLGRKRARLLEEQSGTAKSGVSFGTQAQALGLTSGGRGLGLTIDVARAVGTADAKRRRISGESAASSVGTDESSLGDLSYSSTSTASTVDSLTTLVDGDYFALPAQARTSRARDEPLSAKSAEDEQRECAELLLGLGGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCA3</accession>
    <name>A0A2S5BCA3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCA3"/>
    <dbReference type="STRING" id="741276.A0A2S5BCA3"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000002">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="101" mass="12255" checksum="79A557D527DB569B" modified="2018-07-18" version="1">MPTDDAAYQDLVDRISYSDRYSDDEYEYRHVQLPRQMLKLIPKEYFEPDSNVLRLLTEDEWRGIGITQSLGWEHYETHAPEPHILLFRREKDYQTKYGNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCE2</accession>
    <name>A0A2S5BCE2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_2639</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCE2"/>
    <dbReference type="STRING" id="741276.A0A2S5BCE2"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY74445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="207" mass="23619" checksum="17D50D75E2654782" modified="2018-07-18" version="1">MSTFEIPTEQEFDEQFLSLLTGVPAIFPVDPTDDGNLNDVEKVMYAEQRLKDFRARAKERVDHARDDLRAIARDHKQAELASQRSSAHPTTQAHEAKMTGMRQARLATMKANSELEQQVYRLQGELERLQQELKDEEAEAVDALELDSDILRIKLYRDMGFLPVEENGAISKIVVLSQNSQDARTVEVDDGVSDFKWSEKLWELAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCN8</accession>
    <name>A0A2S5BCN8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCN8"/>
    <dbReference type="STRING" id="741276.A0A2S5BCN8"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000340">
        <property type="entry name" value="MFS transporter, SHS family, lactate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="507" mass="54954" checksum="37281E07CC439C1E" modified="2018-07-18" version="1">MPNIIQQFVANLPRPPPKSSRDASTNIWKVVSSLTPMQYALFFSGWLAWTVDAIDFFSVSLSNTRLTTYFDKPLGTITTSLTLTLLFRPLGAVIFGLLGDRYGRKWPLVADLIICGALSLATAYTRHFNEFLAVRALFGIAMGGIWGLSAATGLENMPVEARGFFSGILQQGYAVGYLLSAVINLTEVPKHGNWRILFYFAASVSAFAALLRAVLPESQVFIDRRAAERASGTVMSSAQKSKIFIKEAGRAIKLHWVRCIFAILLMTGFNFFSHGSQDIYPSYIQKSKGLSAHLATIATIIGNCGAIAGGTIAGYLSQFLGRRLTIIAFCVWTCAFIPLWLLPNSFGGLAAGAFFVQFGVQGAWGVVPIYLTELSPVAFRGVFPGLAYQLGNMISSASGQIEAVAGDHIKTKQGRPDYGRIGAILISVVAVWIIGCCLIGAEQHGSHFEKGKAAFEVGAGRDEIEELDEPKSYTHDLEKDGADKFGQPIHRESASRTDESVSKSSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCU3</accession>
    <name>A0A2S5BCU3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCU3"/>
    <dbReference type="STRING" id="741276.A0A2S5BCU3"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="502" mass="56556" checksum="916800A92C0252F6" modified="2018-07-18" version="1">MAQSAADRSVDVLIVGAGPTGLGAAKRLHQLKHTNFLVVDAQAEAGGLASTDVTPEGFLFDVGGHVIFSHYLYFDDCINEALPKPDDWYEHERVSYVRSFDQWVPYPYQNNITMLPVEQQVQCIEGMIDAAEVRSRAATKPANFDEWIVRMMGTGLADLFMRPYNFKVWATPTTEMQCEWLGERVAAPSLKLVVSNVLNKKTAGNWGPNATFRFPARDGTGGIWKAVAKTLPQERFQFDTKVEKIDASNKVAHLSDGSKVSYRSMISTMPLDQITEISSELEPLRSTSRELVFSSTHVIGVGIRGVLPPRIGDKCWLYFPEDDCPFYRATVFSNYSPYNCPQADVKLKTMQTADPSLSSKVDTTTERGGPYWSLMLEVSQSKQKPVDEENLIAESIQGLINTGLLQPEDEIVSTYHRKFYHGYPTPSLVRESQLKVLLPELREKYSIWSRGRFGSYRYEVANQDHSFMVGVESVDNILFGANELTLEYPDLVNSRRNTERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCX8</accession>
    <name>A0A2S5BCX8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2388</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCX8"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="441"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="522" mass="57722" checksum="6B97B6BF796BB10A" modified="2018-07-18" version="1">MYGRAVRSTASSSNPTRFLPTPRFSAPALLPVRIASFHACSARTYDHSSRHAPNARSPVRRGEEGRKDIAYTRHELLADWHSYARKVSPLDVQWKGKDQIEAQYLVIKADGTVTEPQDKLSKQDVIDTYGLLPRDLRSLDAHLLDVRPALVVCQRSLILCTPIVRAIISHNEIVLIGSDRHNPICNPEDAREMADAVVKVMEFLEMSGSATGKKHSPPYELRALEALLLLTVRGLKNVVSELQERVYRTVPQLRFGVSPAELRDLLECKRAVEDCLLAGRGTQSALSQVLGEDEDLVGMYLSDKAAGKVRDIEDHQQAELLLEYYERRLDEASESCERLRTLLDEIDSNISLVLASTRVRLQNLELQTAIGTLSLGAGATIAAFFGMNLTSHIEEHPSAFYWCVGATSTLMLGITAISWVRLIRARRSQLFLRSSLRQEGDQAPTRTWRAGPVGAVSGGSSEHPRGTSATNGRDVDVHKMIELETGQSSPSEVLGGIAEEAKPDDMGEKSKNPMRRKDGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD05</accession>
    <name>A0A2S5BD05_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD05"/>
    <dbReference type="STRING" id="741276.A0A2S5BD05"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="881"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="944" mass="102554" checksum="ED80A91760F9668D" modified="2018-07-18" version="1">MPPKAETDMAVDDAYESGSDGGQVESPDYGGPPVASTSAGNGTITGLGRRSVKGAAGKAAKRSRSSTVDSELPGKPKRKRNRAALSCAPCKKRKIKCDRKLPCESCIKRGEQASCRWEQPKVEPPPQIFALAVEHEQLKRRVAVLEEALARLAPDVFDPAALSNFEATNTSQTAATARGRPADEAGDDDDEEEEEEDDDDEFESDNEVVEDAAQVLKDLAAQNHNTRTSARAPPAIRNGAPLLNPPPHGSTSLHERRASSTTSAHAGSPLRHSTSSSGAGKTFSAGQGVSVASMLNAPLEHAPPPGSRGPPTRRESHTPEPIDEVAARAMSSLLSSTLLGPISAHGTDPAEQGRRAAMDEIYAGLPQRKAETDWMLNNYFTRVDWAWHLHHKPTFLAEYEAYSTLRAQGRKYNIDPLWLAYFALTLALSVKSLEAPISTPLLSITGQDLDELPEKFVKCAERALECARWRDKPRFRTVQAIVLFAPIYLFAGNAAAVERYKHYLTVAIEMTQSLGLHLLGSDPRTMPALSEDDDAHTGLPPGDSTLKRELALRLLSTLLFLDYTSIRSRTMLPPHMVTSALPGNYNDTGLVPEGIVAPRPDHLATDTSLDQIRHRIALEQYRFKEGMEAQNGEPVSYEAVLATDARYQAILDDIPTDLGEAYIPPLGEPLMTLWRRSIHSRILRLHRPYIARGRVEAQYRFSTERAVSAARVILATQVSLSSAPLLRGAFQIVNIQLAVLVLFSTIWQSSFESREVEADVALITSIFGWLDRHASSRVPEVKLVASSSLKAFRLVMNAYEERKTRQMALEPSAWPSLDEDESFGDALRRISPLVNVSDSIATGATDESLYITPAAISAQSTVGGMSLESLLAPSPLHHLSSSSVGTSLGPSPYGSSTPMSSTPRPAPDATGFDRTLLEGLEFGDPTFSWSTWSPLGPFATLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BD41</accession>
    <name>A0A2S5BD41_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000022">
        <property type="protein sequence ID" value="POY74687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BD41"/>
    <dbReference type="STRING" id="741276.A0A2S5BD41"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="269" mass="30584" checksum="CE5098E39C3C725D" modified="2018-07-18" version="1">MPPRRKPTKAPASTAPPPLPPPTAAAAANGGAVYETGVDQGHPRYLPPPLAEQFRQALTAYETKQYRKGLAAIQPCLDYNPDHGESLVMKGIFYCSTDRKEQGYELVKRGVKNDINSHIVWHVYALCLRADKNFEEAFKCYKRACEIEKDSLNLLNDLSALAAHLRHYDDYVQVRQQILRTQPRMRRNWIALAVAQFLANRHSDACQTLVYYEDMLRDVPDRDVEFGEVLLFHARVLEEAGEYERCLEFLGEKSGQIVDRTAYSVQRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDE3</accession>
    <name>A0A2S5BDE3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDE3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDE3"/>
    <dbReference type="OrthoDB" id="7486196at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="1">
        <location>
            <begin position="82"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="CFA20" evidence="1">
        <location>
            <begin position="192"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="265" mass="28959" checksum="3A4100AB12BCBF28" modified="2018-07-18" version="1">MLLDRVTLPPLVSLFSSTSSDPLVLATLGTAPGVTESFISLLEDSGDAKETLVAWQPAGTSNDLATRVASLAKQHQTNEHEHSADLKDQVLHLQAPDCRTTYARWGSLRKGKWKDDGLGVELPVVHLQVKDLGQAMFLDVAVVDDRGELLVVRASTWQTQARLHPALADEPPILHLPLRFPSASTSSSGTTPLLTSWTTISLPLARLLGSLSPPRRYKATTGVQVHATCRLRRVWFSEEEMTSEVDEAQMRRGALPELALFKAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDL5</accession>
    <name>A0A2S5BDL5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 90</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDL5"/>
    <dbReference type="STRING" id="741276.A0A2S5BDL5"/>
    <dbReference type="OrthoDB" id="2530256at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17548" checksum="9D0BE9FB04F65606" modified="2018-07-18" version="1">MKEVLGDRVEKVAISNRIADSPCVLVTGQFGWSANMERIMKAQALRDSSMSSYMQSKKTLEINPSNPIIRELKNKVQADAADKAVRDLVVLLFETALLTSGFTLESPQTYCQRIYSMIALGLSIDTDELPSSSESAAAASSEDAGDAPPPLESTGASAMEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEG8</accession>
    <name>A0A2S5BEG8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000019">
        <property type="protein sequence ID" value="POY75168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BEG8"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="168"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="1092"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="789"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1530"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1602"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1756"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="641"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1481"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="830"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="891"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1549"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1605"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1644"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1656"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1769"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1782"/>
            <end position="1792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1792" mass="193628" checksum="95907436C842E845" modified="2018-07-18" version="1">MSIRSVASSSARSTAGEPGGRRGYDERPNLAELGVGTSAASSTSSSRPMSPSLTSQRKNTLSSIGERSSISSDAQTTPRIAVASTFSSSHPDKERHFSNGSVGSHRSSTRPENPSPALSSNIPFFPRRTSAASHASHASRTSNPNPLRDSVMSQYVGPSSYATEFHFPRPSDPTEIDALFDKLQTRLGTSSSAADGANRSLDRNKKWLLVESAAHEQWKKARQQLARGSGDPRVAGANGGTRGSRAEHAASPRAGANAAADRMSVRSNGGKNESPEWYIARFMDGTISQQQVASLSVCLRTYELQWLQTFIALKGQAVLASALHGLNKPDTSKKPDPNMEAELIKCLRTLFNHADGARDAIDSNTSISAITASLASEIPTRKSVIELLTFFVARDRVKGFNLVLKGLYDFSTSHRLPGTFDGWFFFWEGAIDGRGRFGSSVGASDAVLSLRGPGKEILRHTPGGSPQSQDFKDQALAEYAATNMLLIQELLRNRDLKIRMHLRAAMELSGLKRILDKHHVLDHPLLRRLTKTYYEEAEDDQAELADQMKEDVRMNFSDPRGCFETILANTDGRARDFLLSTLQHLLHLPTEPEARMRHFQLVERLISAIVTDGKGLEGDLSHLLDRSVAQIVASFADEERLSDVQDELDLAQTRIAQLKQRCAALEEEVASLDSGNVGNLQQDLKRLQDALETSRAATDVTKKELRGKEREYLSQIAALRADNRMLYERLKTAGLLDGVSDDLQERMEVQLQRSKTVEILEGGVGAIGPLPAIPGQSILGTASARRKMESAMMSQRLEAEERLSAGGKEEPVSAFSPDTDYDATPVGERTASTPASGMSSASPTVSARARVTGSHATHQRRPTLAEQIRDVAARMGSSPARDSTDVDSVHSASQHSQTTRASTSTAPTSAATSEIGGHGPFGGLHEGAESFSGAPTTSPRLQLPTLLPRSTAERPDTLFSIAPYTTAPSSPLSSEDSSPHFGSAQLRQRRDATYTGAEQGDEMEEPSTPVDARSAALSGGFVPVELDFNDSEEEPSDVKFKSIACSISHADFGSIDVAIEHAATTAATAASCNSRAPGPPPPPGAPRPSAARTPLQLAQRKLKTFQWDKVSPHGIASTIWARPAGSTKVDPATIAERLQQRGIFDAMAEDFRAKESAQLKKKQDKAALTTYLESRHAQNIEITILKPAGSANDEPATKIQNAVGRILRYEEGIGEAYLTEVLALLPKPDEESKLSMHKATPLHELDFLTPADRLMIELLKIDHLRARLKAMIFRERFLENVDRLEDDVRKVFAASKSLLDAPHFSELLKLILTLGNYLNASNHKGNAQGFKVTSINKLVDTKSSTSSNRTLLHFTAQTISQAMPEAEAFLDELASPAEAFKVDLSHVRTALIDFTTNQTALENLLATHFEDLSELMPDDGFPRKMFRFRREAAERIAALKDLLRLADSTYNQALVFYGEDAKSIASTDEFFSVFKTFVTSYRTAKEDNRRMEEAARRAEEAAARKAEAAAAAAIADQTGDSLVEDMMKSLRDQSLNTPRVVRRDRRKPATSTATSPTPISPGDGDASTARLGDLSTTPSGGLDNLLASGQELMARLTGEGFTAAVSGSPTTSSVLASRLARTRDNRRSANLTSKLTDASEDAATSSLPSSTSLPSLREDPTPRASHVPEADAVSSLLDSSIAGESAPGVTPTAAHETCHRISDSGSEPPMFSTAFSQSELDLAHMVAQGDFAPAAEGGPGEMERAALPDAWDELDKARTDATSLREASADGDDEDGESAEMDAIRLVDSHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEN6</accession>
    <name>A0A2S5BEN6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEN6"/>
    <dbReference type="STRING" id="741276.A0A2S5BEN6"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="64"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="188" mass="20511" checksum="1D2DB75A9F2463B9" modified="2018-07-18" version="1">MSDIEYLRSQLGVHPDFPKKGIVFLDIFPLLRDPVAFETLITHFLHHLTSVTLPKLRADSGNPKAKIDAFIGLDARGFLFGPVLASRLGAAFVAVRKVGKLPGKCFKAEYEKEYGTDVFEMQEDALPEGANVVVIDDLIATGGSAFAAHQLVEQAKAKVIQNLFVVDIEFLKGADKLPAPSYSIIKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEW2</accession>
    <name>A0A2S5BEW2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_1687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEW2"/>
    <dbReference type="STRING" id="741276.A0A2S5BEW2"/>
    <dbReference type="OrthoDB" id="2520778at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY75316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="383" mass="41062" checksum="C9F7253BB2FEF831" modified="2018-07-18" version="1">MATETAQTITVIGATGNQGSGVVAALLDPTKSSLTTERYKVCAVSSNPEGEKAKALLAAHPDAVQAGLLQIVQGDLRDVDSLKQAFKGSYGVFAACPFLPGNGVKAEDSEEAKQGRNIVDAAKACNVKLFIYSSLNYLSELSGGKYTRVTHEDAKAIVASYATEQLEAVTILIPPAFYSNLAWSLFARREGGSHSEKCVGRSELKLLACAADGKVTICVPVDEDVKMEWVDESFDIGKFAAAALRVGPSVSAGKTYPVCSPRITPVQLAEEYHRATGEETRVQRLSLEEAGELVKGSMGESAAVELTEMFSYARRSLRPISTRELTVLHTRRSWLAEVPEGTICSGAMKPKDDMSFADLGVKASSLSQFLERTGFRVPKDSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF06</accession>
    <name>A0A2S5BF06_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF06"/>
    <dbReference type="STRING" id="741276.A0A2S5BF06"/>
    <dbReference type="OrthoDB" id="2526252at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="175" mass="19528" checksum="03DE6D916BD569E3" modified="2018-07-18" version="1">MAPSSARLDPATARSLYRSFRRALARVSRNDGAKRVNLTRLYSPQLRTALVDSDSDPPTLKALLDRTVSLLSSSPALTRNLASLSYHHTPYPLARTNTSSRLYSHAPKPIQWNPQDPEAARRAALKRHRDDERDPTARIARAVEKGLERVVKEAERRAGGGPVWLGRWTTADRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF23</accession>
    <name>A0A2S5BF23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000017">
        <property type="protein sequence ID" value="POY75362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF23"/>
    <dbReference type="OrthoDB" id="2537490at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="573" mass="60257" checksum="31E6FF24469F644E" modified="2018-07-18" version="1">MVQSTLQRPNAQPLSSTQPTAAPVRRRRVHALGLAGVSILFHLYLAGWLAAASRGLDPNERGDDAGLGGGDDARDWEGAERRRVEGVRALLGIAKLWAQCSVGVAVAGLFGILRDKLSFIRLFMLNGFLSLSLDLVLLSTIFLILTVANPSAASGESGLATTVCQALSSSAAATTASSKLFPLSIGLPDMLGVSLEACEEQFEGVLITALGFLALVEGARAWLAIRILGYYAMLVRSRLSPSARSALRGGHEGVFTDDAPLEMDFAAVASSSSPSGSGQLSSQAHAGLQKKKHRRESHGSSSHTEPHRRSSHPPPPPHRERSGSGRTTGDKKRSGDETRIFLLPRSDERSAPPCPSSPSQKQRTEVPLLSLTTSSPVSTTFPPMRPAEVEPSHGGKVLVYAPVLVSPEEARSLGATEVVLGSHQQHRRRGDSHPGLPGSSRHHDQARRRDTPSASDSSTTPVRSRSSTITPGASTGAPGDDPEATPRLGTSSGTLVKTGSPLRPSMSSRPGSTSRSGTPASLTIDAALSRQGTPAPQLPVRQDSMEDAKTPIASSSGYNIAMTPSENKGRKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF39</accession>
    <name>A0A2S5BF39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="10">2.7.12.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_1544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF39"/>
    <dbReference type="STRING" id="741276.A0A2S5BF39"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="157"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY75387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="551" mass="59278" checksum="AE2C1312DA8F2962" modified="2018-07-18" version="1">MDAAAGPSSSLGGGGGVDGVGEIGPTSGGLLARRGKNRNKKGLALGNEAAKPGTLMGSSAADLLQAPAVNPYHSQPSANGNGDPGSRPQPIQVAGSSRSNRTSIISVNSDGTSPLPTTPSLSSSSASSKSYHNRLNEQLATLELGVEFKIDLRNEDLKVLDELGCGNGGTVSRALHVPTKAIMAKKVVHIATSDTTRKQILRELQIMHDCSSPFIVSFYGAYLQDPHICMCMEYMDRGSLDAIYKKVGPIPEPILGKIALAVVSGLTYLYEVHKIMHRDVKPSNILLNSAGHIKICDFGVSGELTNSVADTFVGTSTYMSPERISGDPYTVKSDVWSLGITLVEIAIGRFPFSADADDDDDDDDDLDEGEDEADALARLSFADEARDQLDDLGEDTLSPVRPDKKRESIALAEKQRTAKRESRLLASRTSTDPRAPPPVPPRPRQRQKQLKKRDGVSLGGSGHQMSILELLQYIVNEPAPRLPAGRFSSMVEEFVDATLRKEPVGWDVRKKGPLPKEVARPTPKELLEYAWMRHAAADPTDVRAFARSIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFE6</accession>
    <name>A0A2S5BFE6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_1389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFE6"/>
    <dbReference type="STRING" id="741276.A0A2S5BFE6"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10001">
        <property type="entry name" value="HDAC_classII_APAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF17">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015509404" description="Histone deacetylase domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY75487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="390" mass="42511" checksum="DD2BB9AA617CCEDF" modified="2018-07-18" version="1">MGTARARSTRLARMLVFHTPLLVLHDPPYEILSGCAQPYFESPDRIALILAALLTTKETATPADTASHFEERRCDWTRDEIAADRELMEAVARVHSRDYLDFLREIYDEWVAEGGSKDAALPETFLRRDLLLEPALPDTTSKGSAIARIGRYSFDLSAPVTAETWIAALASTKVALEALAALRTETPAAARPPGHHATDELCGGYCYLNSAAVAARHFQAERGEGSRVAILDIDYHHGNGTSQIFYDDPSVLYVSLHATPDYPYYTGSKDERGGPNARGFNINYPLPLHTADDEYLATLSQAGDDVVAFDPALVIVSLGVDTYIDDPITQFQITGAAYPKMGELVARLGKPTLFVMEGGYNKGAIGKCCRGVLEGFQLASVEVTGRPNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFK4</accession>
    <name>A0A2S5BFK4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GDP-mannose 4,6 dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_1444</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23821"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFK4"/>
    <dbReference type="STRING" id="741276.A0A2S5BFK4"/>
    <dbReference type="OrthoDB" id="10253554at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001053">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="11">
        <location>
            <begin position="47"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY75541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="392" mass="44150" checksum="E42A28DA3341A589" modified="2018-07-18" version="1">MSSDLHTGRTPQQNGAQTTSGLTIVDHSPMSGTSLSPEEYRKRKVALLTGITGQDGSYLTELLLEKGYQVHGIIRRSSSFNTGRIEHLYKDVHEQPNMVLHYGDLTDTTNLVGIISSIQPTEIYNLAAQSHVKVSFDMAEYTGDVDGLGTLRLLDAIRTCGLTNHIRFYQASTSELYGKVVETPQSETTPFYPRSPYGVAKLYAFWIVKNYRESYGMHASNGILFNHESPRRGRTFVTRKISRAVAEISLGQQDCLFLGNLDAKRDWGHARDYVEGMWRMLQQDQPDDFVLATGETHPVREFVEKSFAIVGTTITWEGERDTVDEVGKCSKTGKVLVRVDERYFRPAEVELLHGTPVKAERVLGWKRKCSFDELVEEMVKADIEGAKRNNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFT7</accession>
    <name>A0A2S5BFT7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFT7"/>
    <dbReference type="STRING" id="741276.A0A2S5BFT7"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="383" mass="42910" checksum="6C9F81A91CF9E21B" modified="2018-07-18" version="1">MTTALPTKRIVSRHHLELWLESDAHRQVQHFVDHLNSATVGVKLSDDIHVGANVQAILDVLDDVKQIYHDTPPVDNGKSRFGNPAFRTFYDKVAQRSQELHRRIPNLDERYVAELGVYFCESWGNRTRVDYGSGMELNFLCWLLCLEKLGVTDEKDRTALVIKVFWQYMQIARLLQTGYWLEPAGSHGAQGLDDYHFAVFIFGSAQLKTHKHLRPKCIHDDEILEEFSKDYMYLAYIRYINSIKTASLRWHSPMLDDISGVKTWDKVNSGMLKMYHAEVLGKLPVAQHFYFGSLLPFPVDADADSEAASAEDPDVHVDEHGHLHVRGEAQFEDCCGIKVPAIFAASQEAHQKGVAAGGGALRPLGGLAAAGGGSGAVRRIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFU0</accession>
    <name>A0A2S5BFU0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_1257</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BFU0"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1201"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1513"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1571"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1549"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1579"/>
            <end position="1595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1614" mass="179934" checksum="A08886789709FA50" modified="2018-07-18" version="1">MADVAPAGDGGSPRQRGDSDVDMQPADSDSRRKNRAYDDQDEDGDEEDDEGIDLRPGAGSPGDSSEEEETDSEEEREIRKGFIVDEDESRRRRRHRKKKRSRKHAKTEEGEEGEGAAGDGDEGSSRKRRKDSDDEDEALDEDDLELLQENLGIRRSKPKGKLRRLRRRRSVGSDDDAASPPRGLNDIFADDDAAADQVENLFDADEMAGFIEDDTDDSRSQAGDSDEDRDDARERRNRKQKERERRKAESAAKRKRGGLGGGRLEGVSVEAWQEVAEVFGNGQEYAWAMDDEDDDEPKPKDLKDIFEPSEIASRMLTEADEKIRTTDVPERQQLASVGLPGFDINDEGDLQPLIPEREIATAAIWASDKISREATQMFLLRDADGNRSPLYQPFVKAVEAVLRFINIDLLEPPHIWHHRSDYIIHAPPGEQQALLLHEHDLWKLASLSIKYRALMARRKEFEEQYRPLQTQDLHLAEILEQAGSVEDMMDALGWLSLRYGDELALAKQAKTEDLDGAEQQVGEDGLPLPQAVVGTGAAGPKRMKRAVRDNEYDTARKSVVKKFADLVGMSVAEVAMDVSMQQKTNFPDDPEKSPLDLADEYVVAPDFPVKERVIEAAETILVTEFGHEPILRKEARRYIRDFGVVSVRPTANGQSKIDRLNPFYAFKYLKNKPVAEFMRSPQWMQILAAEAEGLVQSEITLPEQALEKFLGDLQRIYLSDFSSTIADEWNALRSKILDRASREHLFPQAITWARNMLKEESEDVVGAACKDKLEARLDAAPYKRADDTMEAGQVPSVLAISSGRGDPKRDSIVGVFLDTDGHFREHIKIDNLFDPEEKQREAFTDLLKRRRPQVVVVGGYSSATMQLLDNFRNFAARVTQELLDEGVEDDNELDEGYDATETAARKANRAAFESTYVHDEVARIYQNSARATLEFPDLSTLGKYCIGLARYAQSPLNEYAALGQDLGALSYSPNQKYLSKEKVDQWLERALIEVTNRVGVDINRCVRSAYYAHLLPYVSGLGPRKAEALLKKINGIGGTLSTRQGLVLHGLTTKNIFVNVAGFLRIRQDDLDADLGRDAENSEDPDPLDDTRIHPEDYDVARKMAADAMDYDEEDLEGAPPSKAVLDLFNDDVSKLNDLALDEFAAELTKVLNAPKRFVLYQIREELQQPFSEKRSEFKVPNAEERFTMWTGETRRTLDAGYIIPVRVLRVSQDESVLVRLDCGIDGMVGHEYRTDGQVLTRLTPGQTLQAMVMKVDYEALRVELTTRESFLQAGDLGQRQVTTDTWFDTSAAEADQQVAAKSSQKTAGGRAKRVIKHPNFQDISAGKAEEFLAGMQRGDCVIRPSSREDHLAVTWKVDEGIYQHLAVHELNKPNEYSLGTQLRVSDKHRYSDLDELIDAHIKQMARKVTELTSNDRFKGSQESLDKYLTTWTLANPGKSIYAFGWNSDRKKAGQVVLGFRTNERAPISRWDVAIVPEGYMLKGQVHGDVQSLVGLPEVNAFKHAYQYSMQNGPRAGGAAAPQTGYGGRTPGYPGAPGSRTPNPAMQQGRATPMGAGAPAPGGYGAGYYNGGRTPMNGYSGGRTPMGGPPQGSYGGPPQSGMGSGRTPLPPSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFY1</accession>
    <name>A0A2S5BFY1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFY1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFY1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="188"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="443" mass="49024" checksum="AC2F5E4C470D616B" modified="2018-07-18" version="1">MPTPVNLRETSVRASYDVQLEWTFDANLSARPEGGYKSDAIKGVPLRGDWQFHMQQSAEDDDIIELKCSYGGLDYAALGLKVDVTVQLHWISDGRPLLLKQSHFGRKAVPDRPAVDSPTFTCYKGKVSKQRVLKDYLKESFASIQTYRLLIFLSHDPQPELPEGAAQPLTAHDNALSVVHLAKQPQPHDVRLVFPYGEKPARELWSNSTFLSQVSPYYRAMFASGAIETIPRRSKRRRLASPAPASANVDDSSNDAPDWCDSDDETDELTREAEAETAYSTFRAVLLYMQTGYIDFAPLASSTAPRNSFATTTRKEALARDKAKSLRLPYAVSPKSVYRLAHLLQLPALQELALENLASALSVSGAASELFSPVSIAYEEVRKVVRAFVLKHLEAVCATDAWKEYKDRAARGEIEGGAMVLAELFDGMVAAKHAGTNKETTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGC7</accession>
    <name>A0A2S5BGC7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-fucose protein O-fucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000011">
        <property type="protein sequence ID" value="POY75821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGC7"/>
    <dbReference type="STRING" id="741276.A0A2S5BGC7"/>
    <dbReference type="OrthoDB" id="2020419at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="80970" checksum="99452BE03FD71AAE" modified="2018-07-18" version="1">MHQRTPSHSYRIPVTSSPPSLHQPLVVVPTAAGTIPLVPRPRKRHASDDDAYEPLLAHAHAGGAANTADSAAAGWIPTRLGGRQALRKWMLVVLGLGATYVVVSTASSSSSSSASGANDASRGGPSAASWNPVSWWASSATPPLDEPDDWMQPPRVDRTALEKLRLLEIHYGADEGDDDRPPAPPERDRAGAPAAAPGSQATADNAGEQAEARIPPGGGGKTAETDDAPPVVAEIPEFVKPNPLAPPAPDKVATAVLDRRVCGAVNGAPCRFLVPAWLGEQETKAQQHLYQLGLLALALNRTLVLPNVSKSRLGTCYKNPFSFYYSPSSLTDLGIPTISQEDFIDWTLRRETAPTAQVVTMSNAKVDYSLGAVEIDSASDPTLVPSKPTRNLCLRAPRTRLDFAPHSPLSIYPPEGYHRSEAGRLGFGESVITTLRSRKVVSKSSRLSSPPRGPTPAPPDVLAFNYELRFPILSSTVAAAFAHPSIPEAAPFAHFPYADIWTSLGSKLVDRLAPFVAIHWRTETLTPANLAPCGKSLLDKLLELKKQYPSLRNVYLATDYPIESLDPSLGPAPRREGAAATTAAAEEVAHSGTFAKVVTPQHHAALKKFLKDFARRAKGQLRLTTFAKEQGELANEADSVLSPAFVRDLVELTTPLLRSPPRIGTVVDAQADSVPEPVTASEAILSLGQVDSGLYGILDKLVAMRAELFVTGTPGVGSSTVGACAKLSSFTNQLVAAREERMAAGEGLWNTVEHFELAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGG1</accession>
    <name>A0A2S5BGG1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_0937</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the YME2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGG1"/>
    <dbReference type="STRING" id="741276.A0A2S5BGG1"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mitochondrial escape protein 2 C-terminal" evidence="12">
        <location>
            <begin position="397"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY75855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="942" mass="102826" checksum="7CBA9CEBE68FDEA8" modified="2018-07-18" version="1">MLRLYAGRKLLRPRALVPPVRAYAPALRSVATASATGTWSQPDAIHADGSTTTVKDSGGAPEDENVLDEPKQADPTRRAAYLWYDTLFPIRFAIWDVRGVISRLQQYDLLEQVRQLVPEDPRYAVTVESVEARAKDGGAFVRLTYSVPEEVVDEWRTALYRDAEDEAARAAKSKEMEVRVTGLIEREARRALVKSGFRPWFSLGRPCRAFLVQGVPWMEDLDRFPSREIQVEMTGPPIPQEELYAIFRPYGRIHDIVPGDKVAKIIYTSVRSATAARNCLHAAAHTSHPPNSDPKTTVMRIFYTDKQRASWIKDFAANHPRITIPLLVALLGSLSYFVWDPIRELAVRAKVEGTLDANRWRIVRWVKRETLGRLGFAGGSGDRDAAAAMRTGIEEERQQAKEQLSTWLTDSPDTFIILTGPHGSGKSGLVSEVLEDGKNVLTIDCEEMLRGARTESKLVSALASSTGYWPQFAFATSVSNLVDLATMGLIGQKAGFSASFEEQLKAILEVTGSSLSSIATSIKARTAAAIEQSAKRKEESGQRKAIAEQLVADGVRDGRLDAVAGPGVVAELGGGIEGPAAGAEKETSDHVKVEIVGPKSSALVRAAAQEHCAIGCEQPAVSFERLPVVVIKGFATKGDKMQDVLWDVMSEWAAVLVENQVAHVIFTADSVTTMKPLAKALPSKPFNLITLNDASPDASLQYVSAKLAAFDQALPTDDHASVAQLGGRQTDLELLVQKIRAGQTASEAVDDLIQRNASEIHKKLFGDDEEEAKGFKWSKQQALDLIKGLSEKGELKYAETLLTTFGGDDTPLRALETASLVSIQHINGRPSVIKPGKPVYRAACDLLLHDAPFRAAIEYRTAVAGISSAKASVASAQAELIELSKLFTGEQGKWAFGGGSRVPKEIEVRVGQLLEQMRSGEEKAEKLGKEKSRLLQILREHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGJ0</accession>
    <name>A0A2S5BGJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGJ0"/>
    <dbReference type="OrthoDB" id="2526666at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="489" mass="51098" checksum="E25873B20591FE00" modified="2018-07-18" version="1">MAPPRLSANATTPDPFRKILHSLQHEIFPRPSPGVRLAGSVLGVAATLFSRCPGQVDSPAGRLVVLDANRAFAYLAAFGGLVSITGSAFSLLAPPSGTAHAALLSLIELFTFLVGSTAVVAALQSAWRFAPKPVTAPVRLSRRPVNSLCLGSVALGAALITASGIVRTLSARHLDLSFLDLRLQLQRLSAEQVEATPTSVLQLLPGITQLRATADRMHVSVAVAQTANLVCAGLIASVAFSAVRRFRVRGPAVTAAIQLPLTPPGFDSKEDVTSSYFMADSGGEDLESYRQIKARDDLVLVCALVGSVAVVSAAASSAALVIALVPDLYWTRVTARRLLDLLPPVLATLTQAIALGVLVLETFRSQSAAAAADRAASSPGLSEEGPSGPLRSYEPLSTRVIKLSRRSSFRLARFGRKRRATNVSVSSSTGSTRELKGVLEGSDEDSSSLAGSVTPSEASSELANLPTLLNGGDTAPRQSLSRRRSADGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGP1</accession>
    <name>A0A2S5BGP1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGP1"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1163" mass="126870" checksum="187F32E43649874A" modified="2018-07-18" version="1">MVGKISAGEAAVDLVLPTIHHRVHYGPSIAALGDRPFKEDQTWEHTRRLVNKALKAAGPLPDGTQVTFDDLCPEPSRTSQSSSNLNGLRLLREYGELFDPLHPAFEPARLKSRTGDLGNRSAPVLPPTDDAGASAQVLASRIQHAVAQSPKHLTWIDKVDALDATPIYVSQPTPPGFPDIGTSGQPGVSRFRLVLPKSLRENGKWRVIVVRLWLSPGGREKMPFVHLLQQATLPMPPHRRRAFDETTKLYDPAKLSQPIADNLYHALIERLLFQPRPAPSVLRDILVRCGIRLDVAATPNQTILQRLGAEFQVFSPAVEIRLVPQGKKVVVGGKGKPVRAASEPGWTPFAEQRSGKTHDMLEWRLTEGKGVPIKAEIEQRRAQDPSYRYKPVPLAQNLRGSKLLRVSEDVTSHGYSERRIALYCGTDVQREEELAEEVEAIREKKLGCCISACPFNWKSQTPTGDEIPLGAHPDIAHSPFAPGEDEKALCPPHHDLARLVFEVWKASEDDFLADLANIKPFYGDGSLTIVDQYAQFYRCNLGCGRQYGRNREQLKLLPGLPGCPSGTRTGAPSTDSGLADIFHPYSLGTCLACYHRVTKPLLEDYIEQNMRRLDKGKVKSRKDLPALPLPEFYRPRQYTCEVCLKKRKKRVSRIAGTAVELIDASGRTVCDACLRLQIDVPGNVWLTAHLSVEGFDRKVLDPAIQAFLSDPCDQTICEIATSMRSPVAGHPVHPSAFWALLNDTDFLKTFCSGAVFEKVHDIVDALRNGPDFTGDAHDANEDDGEHEHDYEEQDNDGNDSHDEQRNYNEERNDSAASLGGKRRSEIISSQSQSTQRSRALALAEQLVDLPLPGKGKGKAREVDTAALADNIISEVSKRQGGSGPRSTEGLSDSPKPIDGEGPLAPGSSKGDGPRAKPSTESRRSPPRPAAVINLPRSGPDVEMSDESVQPSSKRKKVPLDLDTDTSSPPPSAQGRRKRLRHSTAAYISSASEADTVTGSVPLMSGGTSSEQASRPVGKAKRRSNAMPARSRGRRGGKRKKKSGGNLAGFAVSTDDEDEEEAARTTQLSSDDELMSTSSREPVAVGSEGSENSGSARGARATRSTRARVNYSEARSPEPSDFEPADAPSRKSKQLTQGSVSSDGDDEDAYDDGDDDDAGDSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGQ8</accession>
    <name>A0A2S5BGQ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_1044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGQ8"/>
    <dbReference type="STRING" id="741276.A0A2S5BGQ8"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="4">
        <location>
            <begin position="142"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="3">
        <location>
            <begin position="488"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="2">
        <location>
            <begin position="680"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY75960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="101612" checksum="5C47312613700B9B" modified="2018-07-18" version="1">MSRNAQQPDATTQLVKELLAFGNDELTAGSSSLDREAEDVVANRNKAHSSSREPVASTSRATVESTPTAQFSQLSLKDSSSATETETKAKKAPKSVRNLLKSTSHTLRLRNGDGIEQKRVLTSWKMADYAYKRDPCPFPTRARGLFTERVKGNGDGQEDEYRIVARGYDKFFNVGEVSWTHWDTIAQHSTGPYELTTKSNGCIILIGALDEENLVVTSKHSIGRNANISTEDGVSHSERGEYWLERHLESVGRTKADLARELFRRKLTAVAELCDDSFEEHVLPYSSDHTGLHLHGLNANEATLNTLPSSEVTQFAKDWGLIPTPYSVFPSVLAVRTYSETVQQAGGVEGADGRITPVEGFVVRGHRRGGQPGEAFFWKVKYDEPYLMYREWREITRRLLAAYPDLDSATPKLRNEESRLYLWWVSREIKRDHAKFEPWMHGKGIIATREEFLRWSKTPEADQARRELGQRVEMDAEERRNRRFDRTIIVPVAVQGCGKTALGLELTKLFGWTHVQSDDFLQKKPAPHFLKAIRTALDKDAVVFADKNNHTAKHRGDLVSLAESLYPSHTVRLVALVWPTNSPSLPRDKFHALCASRIVSRGQNHQTLRAGEQHEQIIWQFLGQHEPFDAEVNAPDSKFDHVIEMHAEWEQEEALRHCVDELAKIDGLLPAGAQPPLPKDRVAEAIDFAQKWTPSVRKEATPPAKAKARSKTAPARYYGISVEVDLQSIVERHLPEAERADAKSLWSTLVKSSRVERHPHVTLVHRNELEAEDATVRAEKQAQWDRYAQLVDAAAAGDDSAEDGSPARALDVELTLGPRLAWDGRAMSIEVSALTPKSSSADPASTPSITLAEDRGAHITIGTRASDIRPVEGRWLMEAVMNGKKTTAAGGDIHVVEIEPVKTSGRLAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGY2</accession>
    <name>A0A2S5BGY2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGY2"/>
    <dbReference type="OrthoDB" id="10679361at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54917" checksum="6D1E40D3501AF13C" modified="2018-07-18" version="1">MPYSLFQDFKPTDGKGKPEMAGWRIVQHGTGIIFPEMRQKRRAEAERACEEKQDDSGETVVDASHAPYLPDDIVKMLFTPLITKGDYSDPGFDHEDEVDMAEAIKYLSLSKRFYNLLRPIWLSEIVSTKSALGVERMFERVMHDEQTGGYVRILTFTVFTTFPAKFAKALSRMTAIEILAIDFGPKAPRDARRRARVNLAFLDAASRLPRLKSLNLVPPVVLNAIPSAGFTTLETLNSDLIAIEGNLAKLLKQTKVKYLHLGTDGADAALDHFPEILPEISWHDVETLELGPGADRSCPSDIDAALEQCLDSARAHDTPPGLRKLTVINGHESAEESVFQAALDLAQATRAQAFHYASFKSLPNLRRTLTVDPVYEYVRELRLFAPISLLEEGRVADFFRFVQAFPNLERLAVLDVCVSNLLYRDFYRYKLTDLELSTEHPVLFALLHCLTHTRVRELRVISRLELCEAVWWRRDETVAFEQCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGY9</accession>
    <name>A0A2S5BGY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGY9"/>
    <dbReference type="STRING" id="741276.A0A2S5BGY9"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="271" mass="29939" checksum="37DF17B6E94A77CE" modified="2018-07-18" version="1">MASSTYLSYCITVTNESLLYATEAHAGLDGPFRFFRLVQQRIAHGTLACSAPSPVSRIPTEVWELIQHKLVDKELRRAERVWISKLICDYLWKNEDGCDSCVDVLMEQKGTADPETAQACRAILAKYGLCMPSLQFLQDPVDHKATDSPASPCSKPESLVIIALPPFGVTSAASADEQPSYPTPSVSYDKYFNDAVWNVSFDLPACADDCFRALVRDYHLDVVAVHDGTLALAGTRAEKAGAESSRQVESVKSVRAIQPRWKLFTTVVCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH38</accession>
    <name>A0A2S5BH38_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH38"/>
    <dbReference type="STRING" id="741276.A0A2S5BH38"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="8">
        <location>
            <begin position="53"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="165" mass="17894" checksum="D798FB3640005BF9" modified="2018-07-18" version="1">MATPTSAAARTTARVLRRSLAAPLPSASSSSQTHAASPLPLRPCRKLVLSYSEQLGSHRGMRDFLGSALVVDLAKRNPQTEVVVDRVEGNNKHPILRALYANGRSKEICVRNLPPASILQKAQLLLDSSGHQISASLKRPSVQSRNESVRGVWSAFHEENLGRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH72</accession>
    <name>A0A2S5BH72_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_0827</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH72"/>
    <dbReference type="STRING" id="741276.A0A2S5BH72"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="124"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY76104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="400" mass="43756" checksum="82D7FD461934AF6E" modified="2018-07-18" version="1">MAHKYEKNPKLKDLIRSKIGEYLERAEKLKEHLASLDAKAKADADGKKPVSGGGGGAQAKKGTGDDDDAENKKLRDGLSSAILSETPNVRWEDVAGLEQAKESLKEAVILPIKFPHLFTGKRTPWRGILLYGPPGTGKSFLAKAVATEAKSTFFSVSSSDLVSKWMGESERLVKQLFAMARENAPSIIFIDEIDSLCGTRGEGESEASRRIKTEFLVQMNGVGNDQAGVLVLGATNIPWALDVAIKRRFEKRIYIPLPDPAARTKMFHLNIGTTPCQLSQADYRALAEQTEGYSGSDLAVVVRDALMQPVRKVLSATHFKEVEVPVEDSDPPRTVKKLTPCSPGDPAAKELTWNDVNSDELLEPPLTYNDFVRAVKSAKPTVTQEDIKQHLIFAQEGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BH75</accession>
    <name>A0A2S5BH75_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BH75"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="101" mass="10545" checksum="E69A7054A3033F7D" modified="2018-07-18" version="1">MRSSSRSSTTRRSRCRMSSTRTCSCLTASSSTRTRTSSTTRNSATSSSRSRSTTRTSRKSRSASSRAVSSAASVASARARSRASESAAGSAPAAHSTRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHB0</accession>
    <name>A0A2S5BHB0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">beta-glucosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_0889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 7"/>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHB0"/>
    <dbReference type="STRING" id="741276.A0A2S5BHB0"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="8">
        <location>
            <begin position="438"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY76166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="888" mass="96138" checksum="CF7ED0423046AB76" modified="2018-07-18" version="1">MPALVQDYPRFDVEEKLAELSTSDKVRLLGGKATQNRIRMTGYAEPHTNVRPPRAALECQADFWLLEDIPEKGIPAIRTSDGPNGVRGRRFFNSVPSNSFPCGTGLAASFDLDMMRRVGEALADECRAKSAHVLLGPTCNIQRSPLGGRGFESYSEDPHLGGLVAAAYINGLQSKGIAATIKHFVANDQEFERFSADSVISQRALREIYLEPFRLAVKHANPKAFMTGYNRLNGLHCSEHKELLDGILRGEWGWKGLVISDWTGVYSVDPSIKAGMDVEMPGPPVMRGSTVYRAMGAGKLTEDDLDERVRNVLELVNYAIDSQVPFYAGEEKVETPEIRALLREAAANATVLLKNDAGLLPLSSASGVKQIAVIGSNAKLAFPTGGGSASLAPSWVVSPVSAITERAEELGATVKQAIGVAAFRYVPVLDTYLSHPDGTGAGAKVEIFNGKPEADWLVDDSAPRAKPVFTVDTASSLCFMSDGVPWDQFDRHARTQYTATFTPDISGKWTFGLGSTGYSALFLDGELVVSNDESEWQAGELFFNLGSEERRGEFEVEAGREYRLVLHVYVDPDRVAASPFALSSSFRVGGFPTVDETKARKEAADLAAASDLAILVVGTNPDWESEGFDRKTTKLPGATDELVEAVLAANPNTIVVNQSGTPVDFPWIEKASTLVQTFFGGNELGNGLADVLFGNVNPSGKLPLTFGRRLEDNPSFHSFGITSDTPGKVVYNEGIYVGYRHYDRAKIAPAFPFGFGLSYTSFELSKLSASSVSAEGDCTVRFTITNTGKVDGAEVAQVFVAAPSDGTRITSPVKELKGFQKVALKAGETKQVEVALSKEAFSYWDEHYAKWIAPKGKYGILVATSSAEADVKLRGEVKVEKEIRWLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHD7</accession>
    <name>A0A2S5BHD7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHD7"/>
    <dbReference type="STRING" id="741276.A0A2S5BHD7"/>
    <dbReference type="OrthoDB" id="2530422at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015764222" evidence="2">
        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="241" mass="24920" checksum="53262258C6839D19" modified="2018-07-18" version="1">MRIVEYTLFFSVAVGWIVAAPAPLASPQQDAATAAVAAPATQALVATGPTAQAAVPTQASVPAQSDQSDAETSPMDDPSCITYDSAGLAPDGYSRAYFNGSGVDPQGYAADGFNSTDRNYDGLDRKGYLANGQYALGKDGFDAQGRNLQNLDRDGFRYDLQGYDRSHRDRFGLDASNLDKNGNGCTSTSTDSSSSNPEDAAKLGLPPLQDKFGALPFDTAAFLGTSIAAQLPAAGTGTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHD8</accession>
    <name>A0A2S5BHD8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHD8"/>
    <dbReference type="STRING" id="741276.A0A2S5BHD8"/>
    <dbReference type="OrthoDB" id="10569882at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="408" mass="41835" checksum="726E225F7A5A90A1" modified="2018-07-18" version="1">MSYQVSASTPTQCVKQTIAWSGPAGTKRIEMWVEGTNYFAETIAANVTGTLGTVDWTCDVPAGASVAFEIYALPGGKPYGTTRFLDVQPGTTDACLRQNPSQLRPSSMAALASSLSSASPELFTGYSTTSTPTTSSTSTTASAPTSSSAPPSATSGGSSVQKRALICGIVGGVAGLALAALALWWILRSRRRRASQLGATSAGASTTAFSDKEAPDVTPSTRDPVNAWLGRVQPGARPPSNWTGRSRSQSVRNALIGFTNRSPVATGPSGSASRPRPQGPRADLPEVGEAGDFGAYARPGGGTAGATLWHPTSYTSVPAHGGSGHDVDLPLPSSLQPRGIGNSTLPGQHCSGVAGQSSDYPTPMTSMQASPPRPPTRLTTPGAFSDAAQREAIEAMPPSGQYASRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHM9</accession>
    <name>A0A2S5BHM9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHM9"/>
    <dbReference type="STRING" id="741276.A0A2S5BHM9"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="264" mass="29233" checksum="8C72BEB9B922D05E" modified="2018-07-18" version="1">MARPAPPTETIRPRPPFAHQDGLQSFLAGALARFFSPDPVNQLEPVPVEPPSKQKQPPRRFRKRGKRTKGRDRASAAEVGPQHKVEEDPLVDSFQSLSLAGSSATTPPRTLDWSEDVENRLNGSTSETMSLISQEDAVSYASSVVLATLSSDAGQVVPFDQRTSAEKLAFYQSLILQFDLTPQDALPSSLSKCKELLRTLHVAVGEYLAVIERGGVVSEEVEQYRGVNELRKALGGKKNRKRVPRAILKSQLLTVFMIHLYNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHS9</accession>
    <name>A0A2S5BHS9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter of heavy metals</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_0535</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHS9"/>
    <dbReference type="STRING" id="741276.A0A2S5BHS9"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="11"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="377"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY76339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="514" mass="53479" checksum="3E0B9C1A4F9D053D" modified="2018-07-18" version="1">MSTQKRAFKLKLLLAIDTAFLFLELGVGTVVGSLALVADSFHILIVALQALKLAETSAASSKFSYGWQRAEVLGALINGVFLLALCFSIGMEAIARFVNYTGQPRRHGFDADLPLTLLVIAEVTQPKLIVAVGTAGLISNIVGLFLFHDHGGHSHGGGSSGHGHGHLHGNGNGKKAASEHNGRNHASHADDDRTPLLRNGSALRKPGAGLASESATASGATTPAGSDAGTDVEEFEAPDAEDELCMHPGALRASVVKKAHDAGYGATTTGGSSQQGHVGEHDVEAGLGGSDDHGHSHGGHGGHGHSTADGSMNMRGVFLHVLGDALGNVGVIAAGLFIWLTDYWWKMYFDPAVSLVITIIIKSASFVLLQGVPSSVPLDRLRSSIASVPGVINVHDLHVWSLSESKIVASVHIMVKGPDLVKVSKEIKRRFHRFGIHASTIQPEIVESGSGNAPGQIASALSHISASAAAEIGLEEEGCAVLCGDDQSCQILSCCPPATGTGTNTPTRERTRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHT5</accession>
    <name>A0A2S5BHT5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHT5"/>
    <dbReference type="STRING" id="741276.A0A2S5BHT5"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="398" mass="45371" checksum="5E857C319323D0BE" modified="2018-07-18" version="1">MSCPCNPPFRSEHIGSLKRPTELLAKRAEFDEGKCTREELRKVEDEAIRKEVERQQQVGIKSITDGEFRRHMFWDGFHNNLTGMKLINDPPAEIFKFYVPDVKAFVNSPAKKPGDTMLCVGKLVRDKPMYRPEFEYLKSLVKPDEVRNLKITLAAPEWYHLRHMDNAFDSNVYANADEYFADLAKAYREELADLYDAGCRNVQFDDPLLAYFCSESMLEGMKEEGRDAEALLDQYIKLYNDSVRDAPKDMVIGLHYFKDRASELIPEAVSKLADDRISKKLFQQLNAQVYYLEYDTARAGGFEPLADLPKDKFVVLGLVSSKFPKMEDKAELEKRINEAADFVAKGQGSTREEALKQLAISPQCGFASHSEGNPVNFDDVIAKLQLCTDVAKKVWSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHU8</accession>
    <name>A0A2S5BHU8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHU8"/>
    <dbReference type="STRING" id="741276.A0A2S5BHU8"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="80" mass="9350" checksum="E9A9F232A5BBDD9C" modified="2018-07-18" version="1">MPVLDLIGNPSTEIKESREEAIRQSWIGVMEARLVREELAKCWRTEGVNHYEVCHPLTEKYLDLLRTNRIEGYTKLDFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIJ7</accession>
    <name>A0A2S5BIJ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIJ7"/>
    <dbReference type="STRING" id="741276.A0A2S5BIJ7"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF281">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="2">
        <location>
            <begin position="107"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="547" mass="61198" checksum="AC52D5423026F8CC" modified="2018-07-18" version="1">MSNANDRERVAEPLRRRHGPATSFNLVRRRSTWLALAVAGLACLAYVAQALVWPDDRLTKPSGGAAILSGKVGGAHLASDEFPPLPPLADRTRLWPPEVDRPICQPKIFVYDLPSELQLPATTVPQCRWSAYNSELLLHRLLTADSPGPPALRDHPHDSLYTENPAEADFFFVPSFPACYLFDCWVKAGWKKTERCNVDEGYIQPIMRHVREAYPYWNASGGSDHLLTHPMDYVDGYYTEETRLAMNSSTYLVTVGDARPAPYGQYFRSYRDVVIPSATHLINSYHVNPRDFVDEAGDPLPEPRGAADPKRRLADANLPYPEVFQPSPADVTVCTSVERFLSRLLHGRPKPAARTTLAIFRGGWGEATDGEAYALGIRSLFFPSDGDPSTPPFSSSKHHGFSSLPDFDIALWSENDDYARRLSRSKFGLAPPGYTLDTTRLYEYLAFGVVPVFIGTGPTAGQVLPFERDVDWHGMSISIPRERAHQVPSILRAISDDEYEKKRRKVWDEGRRTILEGREGNVWKLIARQLCRLKRLGVAAGPEIANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIV0</accession>
    <name>A0A2S5BIV0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIV0"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="285" mass="31459" checksum="268F769FDC98B65B" modified="2018-07-18" version="1">MASRVPNPSERLDADTGLKLAAYVHSEGTFIKPDYKLYDANNNLAEACVLARPGASFEVGLVELRASAAMDEGVCGSEVLLSLDGVQVTNEIVADTDPLYKTADTSAARLVRFTGTRVAEDRLQPFVFGDTAIVETDTAEAIGAIDDVERHRLVGRAELKVLRLTEVAFRPPVLRTHEKRVYSKPKNASLKVLSRLCVIPGNDVPAPLIAYRTAERLDGDTPEDPYYTFVFKFEKSEWRKRSIRDADQYRSPPPHILSDASTTADDTTDNGFDSDEDELQVLIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIV3</accession>
    <name>A0A2S5BIV3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIV3"/>
    <dbReference type="STRING" id="741276.A0A2S5BIV3"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="37"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="784"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1198" mass="130586" checksum="DB4160E54C120572" modified="2018-07-18" version="1">MAQDYSRAISASLFSGQPPQANLVTYVQTFEEQPGSPQLKARFLILAALRDGSLKIHKAKQNPNGSFSIGKTWALEHLQRVQVGKRVIQGRPHRNPARQPLEFTLVINSKRYRYDTELPSSQQAQFLVTLVRCWRKYMAGLVQPYADLVLVGFSVDTGSAAAVGASAPSTSTSAMPTAAAAAAIPSSSGQRSGSTGAPSLAAAHARPSTSNRPSDASFASTPPPSAGLPPPVGALPPSQYPQQQPPPPTMPRASASQASRPVSTASDKSRRAEPAGVPPASASAPSGSNSSRPPTSSYPQAGPGSTIAVPTSTSPSAGKATQPQGSGGLSRFQQLQQAARDRRPSGIAPEEKPVSGAGPKLGAPVVKSTDPNGVGIGIDLAGGKLAPPVGVTSTSTSASTATSAPTSSRPSGPHRQNSTNATTGTNADEVLDSETILANVEEMLEGFEWRGADAGWGAAGSSASGGKSRSKADEMERRLVSELKALEAASIHAIMESDDRVVGVVKQVDDALAELDKMDLMIGLYKTQLNLMTDDIAHIESQNRGLQVQTSNQRALLEEIDKLMSTIHIPDSDMTALTQESLESQQGIERLERAAVSLYKALLSTRDTGASSSERPGTASRLERLIRLFFFYLRADMAAASERVGDYKTKASQFAKRFFDFLTVMLKYQVDQVANPKNPADRPPRGALPRHDKMEDFLGRYCGLMLFIKETDQTRYQQICSAYFSTMSELHRQEIRDVLAHFRGQVRKATEEELEASFAARESPTIRQQSMRRVGTIARNPLESGRREKDQDGKSDGSEVFARAIREIVPHLSREQGFIADFLSITSSDSSITFADYMMLETFFRRGATTHLSQQAQQGKLRDIRTAMELVFGFLEGELKAWIDDVLQKDPLQVVGVLAALDSAASRSVAERNDFAARTLQKQYQRLLAVFEKSTKEQVRSIEHTKLTLKKRKGVVPFVRVFPLFVSRIEGQLDSKVGPSVRKAVDTQYERICATILDCLQQMAKMDGEGQGNEGKDQLNYHVILIENMHHIIAVFSSKQRVPTLAPFVGQAREKYDQNLAAYIRLVLRRPFTRPLDYFAGLEQLLRTTPPTEVSLHSAYTRSALRRVTGELRSKDLRKAIDALYKRVDKHFGGDVVHQAADHTDVLRTVWKACEDEMVRLVTAWKGLIAKCYPDEKSGNIDVGRTEIHTLFANAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJC1</accession>
    <name>A0A2S5BJC1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_0114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJC1"/>
    <dbReference type="STRING" id="741276.A0A2S5BJC1"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY76862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="255" mass="26801" checksum="272B7279AA8A26ED" modified="2018-07-18" version="1">MAKLVVVGGSGKVAKLFSSLASKHFTITSLVRSRDHFDAIKQAGATPEILDIENAGVDELKRAFEGAQGVLFAAGAGGKGGKERTKKVDEEGAIKVFDALEQLSGRKPYLVLISALDTRDTSQKPPAHYTEKDIEGSKKVHKAIGAYYDAKLVADQNLSRRTAFPWTIVRPGSLLDDDATGKITAGQTGMGSITRGDVAATISALFDLALQGDGSAPPAAKGLAIDMIQQGKGKDVPVREAVEAAVDKREGSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJC5</accession>
    <name>A0A2S5BJC5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJC5"/>
    <dbReference type="STRING" id="741276.A0A2S5BJC5"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19591" checksum="EC9A96B62D0C7117" modified="2018-07-18" version="1">MSTPSSGAALEAKLQGATSSYAKLEADYARAVEARQLLDAQKTENEGVKKELAGLTEQNKVYKLVGPILMKQEQSEAKHNVDKRLEWINDEIRLLAGPFHALGSVQVQEGEACGGEAAKPLWKDSPIRSDMLILPPRTCKAKLKDVGGKLEEKKIEIVNLQGQYKQQLQAAGAATGPAVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJF8</accession>
    <name>A0A2S5BJF8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJF8"/>
    <dbReference type="STRING" id="741276.A0A2S5BJF8"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="330" mass="37575" checksum="7222AB930B85848F" modified="2018-07-18" version="1">MPVELLSFTPAYCIVGAYRLLHDPKLYKPIWERSKRSLQRAIVLAVPFLLVSLLLTRLWVTFILSRSPFSPKDIHNAAYLGVSPVTYTTFTLTLGQVSMFVEWMLARELRKSRNEVYERTVESRGKPDDWWQPYTEEWAVPPVARASRAAEKQSFYRRLSSPVVRLLLLKVLLTPLSFIPGLSLCILSSIRALTLGRYLHKPLFEVKKMSPSQIELWMTEREINYRVFGLVASLMERIPLVGLVFSISNRIGAAMWAHDLEKRQHQFRTGELRPTRVYQSKTARLAEKQAAVGIDPGVAHGPGGFPTEKGPVKIEGDGILQQRKPALPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZ04</accession>
    <name>A0A2S5AZ04_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_7115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000181">
        <property type="protein sequence ID" value="POY69884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5AZ04"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY69884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="303" mass="30983" checksum="C6422F371067EA96" modified="2018-07-18" version="1" fragment="single">IRTPPVIGLGGGASGSRPATPGGTLLSTPPATTTTTTTSAPRTVTSSSLRTTTSSSATAGTSSRPRTLGATRTNSSSLSTGTGGAAASSPNLGASGSAPPVRASKLGAGKLGVKKGGAINFEEAERKAREEEERIKRLGYDRRKEEEEQAAAAAAXGANGSRAGAGGGAPSRLAAQAAALEAKKDSGEMERLGMGVRKLGFGQVMGVGGEQAAKEAAARKKAAERAASGYVEPEETDYARKTFGNQKGISSDMYHQTGNWDSNATREAQTRLQGFQGASAISSNMYFGRDEDEQQNAHMEESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B062</accession>
    <name>A0A2S5B062_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000151">
        <property type="protein sequence ID" value="POY70051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B062"/>
    <dbReference type="STRING" id="741276.A0A2S5B062"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="86"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="514" mass="56166" checksum="7679F96A2C25C7F3" modified="2018-07-18" version="1">MSNGSRTAKVATLDSPTLRSLDMDDSASTNVCDPRLSMEQLDEALETKDLEQSFDAKAGDGVVWVEWTRDDAENPFNWSRRRKWQTTLICCAFTVSVAFSNTAFSSGSPSMMRELGCSHELAALGLAIFPLGFALGPLTLAPLSEAYGRYPMYIASAVLYLLMFIPIALARSIETVLIARFISGVAASTGGTLVGGTVADLFDAADRGLPMSLYSFCAFGANGLGPALCGWVEMKKGWRWIEWYQMMVAGAIAIVLVLFTRETRASVLLSRRAKKLRDDLQDDRYQCRSDAERSSISVLMRVSMTRPLYLLGTEAIVASFSLWAAFSYGSAFLLIEAVPLIFKNNVRGSLQTSALSRALTSGVAATIGFIGNIYQEKLYRENVARRGPEARLYSSLIGGLLFPAGAFILAFSQDRGHWMGPIVGLTLIFLGIYTIYLAVFSYLADCYTIYASSALSGQSLCRNLGAFAMPLFTTQMYDALGYQWSSFLAGMIALVLAATPWVLFRFGPAIRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0J1</accession>
    <name>A0A2S5B0J1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-fucose protein O-fucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000126">
        <property type="protein sequence ID" value="POY70304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0J1"/>
    <dbReference type="STRING" id="741276.A0A2S5B0J1"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="71685" checksum="044475724C8571E0" modified="2018-07-18" version="1">MFSRRASTQAAAQDEDIRADAVPQASTSAVMRTPAIAQTPLISGADRARFAAEDQAHAKGGAGPKHRSNDSIKTVDKAHAKQSSWTNRLSLDWTRRDGSRSGPGSFLPLGLFSSFTQDGSAQNGAGGRYEPVAPMQARSKRQKSFVELDMDDFADGLRLSAAADGDDEVDQQRYYALREREEKRKRRRRKPSGGIGAFFDQFYPPTVERSRRTVERLAVILTVVIILGYFIFGGDHDPRRPGRPTFVHKAKLRASRTRYPLRSNIPLHSFRANLKTGQGYVTSFPTGSLTTQLVELFKLTHIGQRLDRAVIVTELKAAHGEGGDVPLTDFFDLRMFAHRANVSLVQWRDVKIPDIRGTQQEQLSCWGWKDTRALSRYNIKTDFWPYPGQLQTPVSTETAITFPGIEVLALQDNTKWLEETASRTFPDEATRPSWPDRQLMCFENLFYVPIVKFVYGQLDTSYSIEELPPDSAVWTDVGQHLHFNSHVNHIADALLTALIGSRRKQFVGVHVRTGKVVDWADKGSNTTVELIDSFKKGVDLVQDQLRRRRKGHRGELPVLFTSDTDDAFFLARIAKLGWIHVNHVDFATSARFGGWYPDMLDAVLLSRAVGFVGTRMSTFSHLAARRVESWNHGVTTIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B148</accession>
    <name>A0A2S5B148_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase inhibitor 2 (IPP-2)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B148"/>
    <dbReference type="STRING" id="741276.A0A2S5B148"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="31108" checksum="FBF6796CA1BFB228" modified="2018-07-18" version="1">MQVDSPQPSPRKPSHSNGVRPRGILKNANPSSSSSNPTGAAAGPATNAAHGLAWDEVNLSMNDLQKDSTMKITEPKTPYVRYNAETDQVMDLDPHSLEHVLRTSEIPGISLGTTSFGGHSNSQPHSPSHLSSLLDSRVPNSNSVPSRPAARRSSEGSEKMVRLERSASDLTAAGTSSSSSSQKDTNDGAPATGASGSAGAAGDSNMTPSGSDVVVPAAAGDDSSDEEDADEETIEHRREFAKKRGRHYSNEGMAMKQAAALLAQEDDDDDDDEQQPNGMSAVPPVPQIPNGMQLDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B167</accession>
    <name>A0A2S5B167_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_6420</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000115">
        <property type="protein sequence ID" value="POY70506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B167"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="322"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="17">
        <location>
            <begin position="1579"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="607"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1150"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1208"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="628"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1171"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1243"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1272"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1342"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1410"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1445"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1472"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1520"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1550"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1565"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1580"/>
            <end position="1592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY70506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1724" mass="177986" checksum="D800E4671C819875" modified="2018-07-18" version="1">MPPFAALPRTAVHAWCPRLDSHSHSHSHSHSSSPGPLLVTGTVSGALDDSFSTDSQLELWQPFQPDQGGVQHPVATVQWNARFNSLAWGKHAGTESAHTPLGVIAAGLDDGGVALWNPDCLLNRSATGRDPLIARLDSPHRGPVRGLDFSPAQSNLLASASSGKNSIYIWDLTSPLKPFSPGTRSRSLDSITSLAWNPSVVHILASSSNTGHTVVWDLKSKREITALSFASGGATGLGPSGFGGGGVQGGGGGLGPAGFGGVGGVGSAGGAGGAGVGGLGGHSAVKWHPENPTKLITASEDDHAPNLLVWDLRNWKQPEKVLRGHDKGILSVNFCPDDSDLVLSSGKDGRTLAWSLQSGEIVAEVTPSSNWTFESHFVPNNPSLISAAALDGELYLHSLQSTNSREHEDDAAAAAAAQQHDATSQATGAGDFFEQAISANAKNYPTKSLAVAPKWLRRPSSAVFGFGGRLVRIATTAAAAAPGAGQTASTSRVTIERVVTVPGVVDRAEKLERAATGQEEGGLAKFCDDRAAGTSDWDAAEDDEGDSGLTSATEKESWALLKTLFHAAAGGTPGAGGPAAREKLVEMLGGFDRDELKSRVDKLARELRAKLPPLPTTTSTTADNEDDSSPRSDSHTEAMTKSEDAAATSEPSLFGGAGAATTAADGADGLNGFGGDDFFASLGQRPSALPDRLTQESAARGGQPDASSSIAATIGSGPSSLESVNVKQATFKLFHDEATDADKLVTQALVLGDFGSAVELALSTERYADALLFALQSGSPEIVAAVQREYFARTATDRPYLRVLESISATAVGGGGRDLADVIQNADLEQNWREAFVVACTYAATDDEFSSLIEQLGQRLEYQYELVSGRAGHVAAEQWRKNAVLCYLAAGKLEKVVGVWVQQMQEDEQARLGDSAAFARGTTAEDDAAASATARFEAHSRALQAFIEKVSVFQHAVGYVDVDLATPTQSTAVAESGARIYKLASLYDRYIEYAELLANQGKVDLALKYVAKTPADYDGTNSAVSRNAMKRERLLRASGAGQQLRQQQQQQQQATYGAATGYGASSAGRYAQNANPYGARANLPSVSAVPAPATNPYLNPLATPARTAYSNPYAPAPTQSPAASSNAYNPYAPAPSAPSAAPAVVASPMRSNPYAPAQPMTNPHDDPYAPAPSAQASTPSAIPAAAPPSSIAANPYAPAPTANTGLAYASAPSASHDPYGPSSMASNPGAGLPGPPPIRTESPNFAARNAPAGANVPPPPRAKAAGGWNDVPTLPAPRRNTPAPTATAGSSPAPGAPKPAAITSPFPNSSPSGTPGPYGAPMLGAGQVPPPPPSRGANRTPAPVPPPPMTGQAAPPPMSGRVLSPPPVAANPQYAPAPPRSLMGSLGPGQSPNGAAAGPSSIMPPPPPQQQQQPGQAFGTGAAPGQGAVVPPPPMSAQRSGPTYAAPPPPRTGTPSAPPPPRANAAPPAPPSVNGATMPAFNAANQAPPPQQQQQQVQAPQQQSMQQQQPNQPAPQQQQQPPPPPPPFGFARPPPPPASSAPPQQLSQVGPPPPCSAPGTPQAPPASSFPGSPPMAAKTGPPPAPAQPPAPQPTQQAMPPQPPRMKYPPGDRSHIPPANKPILDTLSAELQKLRQTTPPQQVKIVNDTEKRLNILFDMLNCETLSEASTQRVLELCQAIRARNQAQALDLHLQLITSGATDVTPFQAAVKLLVQRMMIPAPPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1M6</accession>
    <name>A0A2S5B1M6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000112">
        <property type="protein sequence ID" value="POY70656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1M6"/>
    <dbReference type="STRING" id="741276.A0A2S5B1M6"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015441237" description="NAD(P)-binding domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="340" mass="37689" checksum="B94869EF2A09B37A" modified="2018-07-18" version="1">MTKSLFILGTGFIGGSVLSALIEKGQYEIAALCRSDDKAKKLEELGVRPVRGELSSDDVISREAEQADVVLHIATADDLPSVKSILKGLEKRDPSKPRAVYIHTSGTGVLTVPTHPDDVCFNDKDQAQFDTLIPEHAPHREVDLEIKKAVEEKRVHAKVAIMMPPCIYGLGTGPFNRRSIQIPLWAKEAVKNGHVINQCVPSISLRLHNAVLNHSLRFFSGPQNFWCNIHIRNLVGAYETLLAHLEETDSTAGPLYIIAETGSHRWGPLGVLLDKLLKERGLVGGEMTEEKEGSTETETGTQSRSKSEWLHEWGWKVKEAPSIEESMPEEIDHMKEIGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Q0</accession>
    <name>A0A2S5B1Q0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000098">
        <property type="protein sequence ID" value="POY70712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Q0"/>
    <dbReference type="STRING" id="741276.A0A2S5B1Q0"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="562"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1072" mass="116279" checksum="E6E25593D01B32B7" modified="2018-07-18" version="1">MQSTRGRSLVWDPCGGQRFLTGGGSEIRLHQRDEDRIRTTSIVTELSGLRSFAWCPDAAQQAAAAAPLVAAGMSSGKVLMMRMDDAAAGAKDGQDAGAKPLGQLNIRHPRPVNVVTFASNQPQLLAVGLEKGRGESLLVYDIERSAPSNREPPSGRQSALRREPSQSSRGRASSPANTSTNDPTPLVTFGNSDFVTSLAFLEPPPASMNGGSGTSSLLAAATAGKWIRVYDLRSPSATVATWSSRAGYGLAVNPFNLNQLSSFGDDGVVRLWDVRKPMDPLLSFSEADAGSIPLQRVTNVSARPLAETAWSTTKRGVFATLEKDSPAVRLWTLTDGPGPRLLPQQDSQADRQARLGVRGRDMDSSTRVSNAAVWELIKRERALRCIRRPVAAQPFNNALISFSFATPTTSASQISLLGLSRDTSSAGSSAQRLEILDIPSTSSASLLERSVVITAETGEVKRFDIPNAEEAEEVDFGAVREPSGPTPRTPALQLALSPRDRGRRLSLAGAAAPMMDRNQTPRPSAMLLRQESAGDVLQGAGPSALDATGLYNLSTDMSVVLRERVEAGYGSDPMTNAQLSEAGVREFWLWVARAQTLSSEACVPEYDFRFRGVLRILLGFPSGMTNSSAASPRRSTPTQSPLPTPRSIYGDISRSLRRSEEAQSKHAAYTAACNQLVAERRLENTFAISSSQFAAQRKIALSSCGQDWEDDWEQVCNRRVLLTLAKIGDYEAAARFAFYAGQLEKSMQYLRFCQDENLRLLAPVVAAYLAQKDSARGADSHYASLCRTLSSDVETPWVRAMFAYLATSDWRELVDEMGLPLRDRVAVALRFLSDSELIPFLQELGDEALSSSDLEAVVLFGLRNDGLRLLSSYVDRTADVQTVALACSFTSPGMIRADMRVTRWVETYRSQLDRLQLYSARATFDAARGRRARATLEQARAAGRTAEAQEVAQAIRKTAPPQIMIRCQFCSTVIAPAKGALNAGDFGDLRHPSAGVNRSTFCPSCSKQLPACCICLGRPSLHSFRSDGPTALAWCQRCRHGGHATHLLAWFETSDVCAVAGCECQCNSDRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Y6</accession>
    <name>A0A2S5B1Y6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000097">
        <property type="protein sequence ID" value="POY70776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Y6"/>
    <dbReference type="STRING" id="741276.A0A2S5B1Y6"/>
    <dbReference type="OrthoDB" id="5582162at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="338" mass="36040" checksum="F515C0DEDF88F1FE" modified="2018-07-18" version="1">MVLFGFGDFDYACRNIPSMPICNLFFRQLLVNPAGTSAPAYNILGLPAPGSSNFNSAVKNHGVGGFGSCYIPRAGFAGGESGRLGNIANLILCGIAVLVGLGLAAAAIRRTAAVGRVEYTTLFVMYALVQGAQLADNSGLLRQGSLAISWVTAIHTGLLVGLFWNLVWAAFLSLQVVEDGTLFSLIPMFVIGIILTVGSGYIAADTALTITNYFRSEPARSLHNNWLFVLTIIWPAAAAAVYFIIQAGVVVRILREKKPLFTLLGAAVAFIAAQAFYYALGHKICTGTNGKIDSSWIATLLETVSIGLIFAAWQFVTEDEWESYDIPTDPSAAGGYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1Z8</accession>
    <name>A0A2S5B1Z8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_6295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000098">
        <property type="protein sequence ID" value="POY70711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1Z8"/>
    <dbReference type="OrthoDB" id="2523997at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY70711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="522" mass="57262" checksum="2A9F8ACE1AD9A23A" modified="2018-07-18" version="1">MVLIRVPASRVPAGMNPYEFYIGVLESVFDMDPVRGFTARLAVLWALCAYGLIMSMVYFGVLVIEYRQRKKTIWLWRLVRRSNGRYIVGNQHALFAIFSLITCAVMIGYLVNFHQVFVLKTHQDDAFYWRTTIFIAFGVQLWVTSFANLQAGILASQAAAKKYILSPVLANTFYIGAFLAMLLSCLSLDIVCGVAWAQCWRAHVQVLAQLRTLSVTRVNDTPAQAAALVNGGLLNRVNSRLGLTIATLRAINALYAFGFTLIIAANLGGLALLFTLRRQINFNMRRMSDDQAVSTPGIALTPPEENGDPLAAAAPRPFSFATRINEKSSSDSSKSPARQVVFVRSVEQRLEGPGGVSEDRPYHSGKGMSVGELKQAAANDAPASAANRAQAKQLLALRKVQWDVIVLLIAIVIIALTCVAIGLWLAISPTSVYARWATTEVAYFLVPWMFLLGIDFALSFLLFNALRHLVPNDSIFAKLFGQGKATARRSSASGLLSSDELDSMATESREVDEVAIGARQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2D1</accession>
    <name>A0A2S5B2D1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2D1"/>
    <dbReference type="OrthoDB" id="2528452at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="59"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="730" mass="84034" checksum="93947DE53A1CBFB1" modified="2018-07-18" version="1">MAAASLLIPSRTQTPEKPTLEPLPVFRARDDSYHLHLTPGRPYLTAYEETEEDDEGAQSDRFSGLPLEIIELILMELPPDSLLSASQACRRLRQIMQGRRADEIRRASRRRDGWPDLAAAQVTEREYSRLITSARCYICKGYTPHGIYPDLRLILCRNCQHNWLRTEGQIDNRYRHIHPEAFECAVDLGSVDVYFEPDVLEQTAELCLAEAKAILRNRRPEEAVSAHVDLRAVYLVVNAQDGQSLRERFQDSARRFEADVEFERNVLLTYCREQLVALVYDTTDCAFLWDDDLWCECNSWDIDWDEFDREDERYRRKLFGRDEPTTYDGWLQLIEECIEEDEEDVEEERTWLARLPYDRADFDRYTEWISQAFRSRNWCGDEEPDIPDDVDFTAHETCLHPPEGLLDFWDEQYGFRADYKEKGAPPFDSHWKAYKRVFIKLAERAKVKRLHEELVAAAEARRRALKPFYEKLSTQDPLAARLAFDSFSYLSPTVTELWRPADAQKRPSWWTKAEPAVLAAVRKRVEADKLRLFVRLARSLFADGDRDLPVWTLALLRNHNVKPTELENGCLATTDQHADMDEIFSRATALFRCGFCSSKLIYEDLATHLVSKHDAGPLTAYAPLPSVEFRKSIRTVLKALGLPVTTAAASLDSYKYEYDVDVRAPSGLAFRLRDQTWEQVLLGKTGSELKRAWESGGAASTDRKIVSIRPAMSGHVAGQTPLPDSVSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2R2</accession>
    <name>A0A2S5B2R2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THO complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000088">
        <property type="protein sequence ID" value="POY71067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2R2"/>
    <dbReference type="STRING" id="741276.A0A2S5B2R2"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35468" checksum="FA77F9330CE6F2A7" modified="2018-07-18" version="1">MKPRERLFADASLRPYAETRAQSDSKHLKRVSKTIRDFYGLLADDARGDKLLAAHSILTVGLDQLEQQLGKTKRIELVTHAEIQEYRREVAALEQTSEETRQRLVDLRKRLEEAQQERARRIEYDAIAKTISKLPDREKGKESLDKLNGDIELLRQEERTYSETWQTRKVAFDGIVSSLEAMQEAIRDEKAEQERRRALDEDEADAGAQPSAAGGDSAASGTQDDASRPQRRDDTGDATNTPQRAGSLDPNAKVFVPGPAGAEGGEEGEDVEMRDPDTEEEPRRQAEAGAAETDDDARRTDREEGQMTDDREEGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B305</accession>
    <name>A0A2S5B305_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B305"/>
    <dbReference type="STRING" id="741276.A0A2S5B305"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="225" mass="25519" checksum="E95754B7112AE9CD" modified="2018-07-18" version="1">MSAKTGAYGANSKSDTNFRKTWDQKEYEDKAKAKDQELAENAKAAEEAMQQGKRPPRKKEDLPKATEAMKARDVPLDLDKNLNKTIVIDASVGSGQKQPGFYCDVCRRTCKDSARYLDHINGRNHLRRLGQTTKVKTSTLNDVRLKIAELREKSAAAADKKQYDFEQRIKEIKLAEAKEKEDQREAKRRKKEEERQKAEDELNKGADKDMMAMMGFGTFGGGAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B347</accession>
    <name>A0A2S5B347_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_5485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B347"/>
    <dbReference type="STRING" id="741276.A0A2S5B347"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="628"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY71175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="751" mass="81415" checksum="3B936ACC3E6A54D9" modified="2018-07-18" version="1">MPATPRTQSQQAITGELGRDSDSATANERSPLLPTSTAHNGPNGPHRRKAKSMPALKPDPASGSSTPKDGRPAAGSGSGGTPQSRQEVALASLPARLERAASVAQKREEAERNRTQWQVLSVKARYYIPVLQWLPQYTLKKFVRDVVAALTMTSVIAPQAMSYATSLVHANPVSGLFGASVPAMIYSVLGTCRQLSVGPEAALSLLTGEIIARFIEEEEHAHGRMSEGDKARFVAGLITLITFQSGLVTFLLGFFRLGFLDAVLSRALLRGFMTAVAITIFVAQLIPILGIEAGLTAEYGASSTFEQKVGYLIRHCGDAHRLTLLISLAGLVVLVSMRILKKVVASKRGAWRAFKYIPQVLLVVVVSTTCSHIFRWERSGVAVLGHVSAGSVKVQVPLWGWEDGRKWATKCLSTSTLIAVLGFLDSIVAAKDMASKYDYPISPNRELCALGFANLCNSLCSGSLMGYGSITRSRLAASTGATTQMASLLTGTFVMLVTYFLLQFLSPLPKCILATIVCVVVFSILEEAPEDVMFFWRMSAWTDGALMLLTFFLSLFVSVEVGITVSVALSMVLCIKHSTAMRIKILGRVPGTASFEPLDEDETDDGLFASLGEEVPGVLIVRIRDVALTFANTGPMKERLRRLERYGHGRHHPAEDPRRAEASVIIFDLGDVNEVDASALVILLELVEAYSVRSVLVYWTQCHQKVLARLREAGVIEKSGGDRFVQPTVFAALEELQETVQNAGQSQVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3B3</accession>
    <name>A0A2S5B3B3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BMF94_5590</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3B3"/>
    <dbReference type="STRING" id="741276.A0A2S5B3B3"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="577"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="POY71278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="616" mass="65562" checksum="084F7D2511A237C6" modified="2018-07-18" version="1">MAEARPRKRFVGRQPGQPASGSSSTRSHSIVAVNGQHQQATDADPLLQAAIKHLLPGNYNFEVEKSVAQVKRNGARRVALQLPEGLAMYACSLVDIIERFAGCECVIMGDVTYGACCIDDYSARALGCDMMIHYGHSCLVPVDTTTIKTLYVFVEIQVDRIHLAQTVRLNFPHCIPNAAASASSAAAAALGDTKGKGPELEIAIEADSPRTACEQQGGSATCAGCQCQSHSTGPSPPARKSKTKLAVVGTIQFVAAVQGLRADLDAEEASHVQRLAIEAAPSAEAVEAGPPTTAAGGGSGLAAAASASTPLEQEERTEFELVVPQVKPLSPGEILGCTAPRLEADVDALLYIGDGRFHLESIMIANPLVPAFRYDPYTKRLTRELYDHDEMRQVRGLAVAQAKESLVENGRKADAQDREAWAVVLGTLGRQGNLRVLKSVTRHLEAPPSRNGGSAVAATSPIASTPFIPILLSELSPAKLSLFRGISTYVQTSCPRLSIDWGYAFPKPLLSPYEASVALGVSNARGWKSMGLTDDQKRAKPFLAELENGRKDDDDYPMDFYADQSLGEWTPRFGMGVRKAGGEKGRPVPRRKRPVATAAAAPAAVDSTLPPPIPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3K0</accession>
    <name>A0A2S5B3K0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3K0"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22087">
        <property type="entry name" value="F-box_FBXO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="774" mass="83179" checksum="CDBDF161EB648AB2" modified="2018-07-18" version="1">MLSGQHDTVMDDQDPPRASFLTLPPELQLRILAESDPQSLVRLSQTCRDCYHIARAQSLWRAIALDLVSRHRYVQPATAARPPAGHFAASPAAADWFNTAAFLLRNAHHLGYFASSQPFTWNVPTPPRNSSRVVRVGIVGPAPDQVQPDAPPPRYTIRASQLVPRNLLANPLAPLPPDLLPFGAVQHALEPGSWLVSPGQNPRHPYSGFSVDFLEPAYEFDADMFDITPDEGACLPRTNSHTREAIAAAALGAAYPTASIYNVDAAPRLRLALEPVSQLVAPSSSASASRLDPDPTGQAETAPDPMERLGLNREALFALFSGRLPRRPWPTAQLVGLDSVNTADLPLLRAGRTDPPRNVFRIAGGGAFRGLEEWLTVRQGTQGPLAEIVEPDPAVLSGQRANDKPAARDDHAYVKGFRLRAKRTTTARPPFTSEGASASGSSGTADRWSSSQDTTTRRRGVGPNGGMAVLWQGGEPDRDRRPPITLVRADDTTQGGFVLRLPGSPPQPPTAPLPLGEHVGDLDGTHVGGMGADATSEHMADAVDSAAEGFFPVKAPARPLTWPLSDHTTATDAHGNLLACSLEGYWIGPYSSHGLEILNITTGLAEFPSQNASDGDSSDSDDDSVTYRQVVTATKVTGDPNVPSGQTSWLAILPASAASDRPSAISDGPVPSVRAETFHHLSSLDPSSPVYQGLNNGAGPDWLEGCVRGYGRIALTGYTSPSYSPAEIRFLRSEVKLQRPDQPGEQHIVQSIEEIHVRWLEMHKVTTFKRMRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B492</accession>
    <name>A0A2S5B492_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000083">
        <property type="protein sequence ID" value="POY71531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B492"/>
    <dbReference type="STRING" id="741276.A0A2S5B492"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="419" mass="47339" checksum="8C107993EFC83C13" modified="2018-07-18" version="1">MHLGEAKESVPGDDKAKPSLWPLRSDASDPSYDLRALKATKPLPYRPFRYGPNYPQHMAIRNIADASTWLQLDREYAQTVDLRKRRMADPSLYSSATMPGYQAHALEALCEMSSFLALRFPRLFTVKRNVYDPSDPTTYGDSTAGEEAGAVIAVSNLITGETYNFPEIAAREGADWNPMHIAGSLLQDDLALMVEDEETGQYVFRAGSICTAGFWRLKDKLGLTLDEIHFQGAVPNYAEKYQKAMNKFFTNLREDKLVERNNYFFQVKGGLDWSTETNGSEEVFDQFNKGPQADAAKLEGTKQPTGATDISEVYFRCERQTLRRLPRTRAVLFTIRYDFVILTYLLPVTSLAHEPGVPGRMASGVRSWPKGERSVEWYKGAELFAPILLPYLDHKHEEQVRSGAITLDAKGMLEEKYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4F0</accession>
    <name>A0A2S5B4F0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4F0"/>
    <dbReference type="STRING" id="741276.A0A2S5B4F0"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22933">
        <property type="entry name" value="HFD_HFI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="733" mass="74601" checksum="9206D2D4730723A9" modified="2018-07-18" version="1">MDGIFPVASTSQAMAVVSVPALLPSPSCPPARRTDLVSLKLQLAELLTPEQGLAYWSGLADFFTGRINRNEWDDVMKRAFGRDRVKRQLALKLHNALVLSIVYNTTRPFAPPTSIRHSGFHPRGAKKRARDPNAGPPTDLEEKRKRLVKDAVMALGRRERGEVKLLGATTASTGTTANATSSTSAGKLKGQMLAADEERKRKRRAAEALSEAVDGTSRGGGGDVTAEGVPRALLVGGGKDPATLAALASDYNRLLQAPLCCESRYLPDGDTLHDRMLAIGFQEGMASGIDGRAAGLLNGAMEHHLQNMIASVISLARGTRKAIPPAPRTASSSVVSTPMPSTFAPAGAAPSAPSPVSAPASSPDAPTGPVKPKGKDIQDDADDSDLDERSPLSIADFHALFAISPALLGQHPNIAAVERMYAIAPQDSDSDSEDYDSDEGDAAQQSSAAPVRRVTIDAAAKKEEPSTSVSGAAAAVAGTPSSGAGSTGVGAGKHPRLSRSRASSFYGINRPIPVSSPAAAVTAAATSGPSALGKGRFVIDPSSRHGVPEGHPSVPPLPSTPQALLPTWLGGSHGSNATNTGGASGAAAASNAPSADLSPKSLALRNSLFPELASGSSNGAAAVASSGPAGTDAHPDGNSTSTDAGDSDSDDESKKVPAVPKAPPTTTSTGTGLKIRFGGGTVQGANQPTGPSGQRLSGSAQGAGAAGPPDRETGRKLWEVVDSVGLLDGVLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4F4</accession>
    <name>A0A2S5B4F4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_5355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4F4"/>
    <dbReference type="STRING" id="741276.A0A2S5B4F4"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY71660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="56548" checksum="D7E2F127BFF6E500" modified="2018-07-18" version="1">MGLTNLVRGAAHSISAGSPNAKQQPVPPAAAGNGTTAGASPSASAPAAQASSDDKIPEGALADDTEVLDDEPKNIILSMISQLRPGMDLSRITFPVFVLEPRSMLERVTDFHSHPDLLHGASDLDSPEERFISVLRYYLAGWHIKPKGVKKPYNPVLGEFFRCRYDYADGTSAYYIAEQVSHHPPISAWYFASPDQGLELCGELRPKSRFLGNSVANYMEGESHVKFLTGKGAQDGEYDITMPSMYARGILFGKMVLELGDSSIVRNETTGLQCEVEFKTKGFFSGSYNLIGGKIKGRKGDVGELSGHWHDSMELQRKGTRQRETLFDARTARAVQKVVAPESQQAPNESRRLWTKVTAAIKANNDAAATEEKSAIEEAQREAARKREASGEAFQARFFKPTGKGGEWRPDFQLPAGDSKVQLEAVRQFVYGDDAEPPKAGSAANSATSSPTTSTAPLAAAPVAAAHPTPVSQPETASAVPASVRPVPRTQSTGDSDSFYDAPAASPHTVEIAKEQDPIETTTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4I7</accession>
    <name>A0A2S5B4I7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_5280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000074">
        <property type="protein sequence ID" value="POY71688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B4I7"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000221">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1097"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1173"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1322"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="189"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="619"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1061"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1378"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="941"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="941"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY71688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1621" mass="174005" checksum="335395BA9D5E0B3A" modified="2018-07-18" version="1">MDHPLAPPSITTTPPATPRSRRPDPATPHSGRVPTIIEPASAFSTATPSPSRSPRLGQASFDASVAETADAPPYTARPRQLFASVRDLESRYSPASPTSRSASDYKWTVGDAIARDSRGSDDLDGMSSPPSSASGRKLSYTTPRARAPAAAAVVPVQSQQPSAPAVPATFRTLFSLTSRSTLLCVVLPGTACAIGSGLIPPYMTTLLGDALQAFTDYGLATGVENLAPEALDAARSKLLSTIKSQSIKFFVLGAVVLAASASNVALWVVHGERVARELRSHVYKGVTAKGLDWYETGMGGDTGGDQDGATSAVDAAGLTGRFSKDTDDVRVGSAQTVGLVLQYLSSSLFCIILAFWKNWRLAFVVLATIPIVVVVVSLTERWSGPMANRNRATTAECTSRVNRIVSAIATVKAFNAEEYEQKAFKALTHADWAAYTRLHLVWGLRSGFTQFLLMAMFVQGFWYGAHLISTGQSTPASVNTAFWACLLGSSYLQTCIPSLVALEKAKIAMAGLLQLARPEPDRGAPHPATAIVSAPKKSSRRRKSDRRQDSIAGTISWPIPSDEKAEIDSPIEPYSPTSMDFKAQPNTFVPLAGVTVKHDRQHAPRALRKLRPATFSGELSLRSVTFHYPARPAPAPPALENVSLYFAARETTFVVGTSGSGKSTVGSLLLGLYNVDDGRIEVDEQGLEWIDEEWLRAHVACVSQGASVLLEGTVHENIAIGAVGQLREDGTTRSAADVTRDEVIAACRAALLHDFVRDLPMGYDTPLSGERGASLSGGQRQRLAIARAYIRDPTVLILDEATSALDATSRVLVNEAVKRWRDNRTTIIITHDLTPIAPHDFVYVMAEGRVVQQGFREDLEALGAGTFLEMVHAQGGGEAGPAEEGAIEELVSPEAALSGALAPTIEVEDGRRASKRLSAMSLLFPPAADDVVSAGRQLWSPNRSSTASASPSLASTGFGAPYLQPPEHPSHPVDGMPDPKRGSYQASLSALALAGQRAIQSRVDSRRTAGPRRASHVAAKQGEVSSADDCGDKISSRAARRTVYQLARRYWCTIPNKMLFVAGMVFSIMVGACTPLFSSFLSKVISNLGNPNAESIITQSAIVVLALAVVDGSCSFLKFYCMERCAMGWITSLRRQALNKVVRQDKAFFDGPENTTSALSYSIIKDSEDARTLVGTIIAQLTLLASMLTIGITWSLVTGWELTLVGFGMAPIIIVVTRSLASVLNRLEAHNKDKREEISKHLMQTLSNVKAIRSMSIQPVFDNTYQTCVSTTYTGGIKAAPFAGLGFASTFALTYVSQGVMLLVGAILVVHGRYTCTKMLQVFSLIIFTVTFAGQLMNYLPAMAKSLQAADDLLRLLDLPDDTRESKGELVYPVSGRVDFDKVNFSYPSRPSVPILRSVTFSVNAGECVAVVGASGSGKSTVAALLQRLYEPTAGRILLDGRPLSDTKTSFLRDHTAVVSQYPALFDMTIAENIAYGREDVDLFDIKAAARAAHIDDFIEALPLGYETKLGDNASFVSGGQAQRLQMARALLQPRELLILDECTSALDPTNQKLVLETIMRIKEGRTTLIVTHKLAVMEQCDRLLVMSEGEVAETGTMSELLAKPNGVFASLASGGEWELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4K1</accession>
    <name>A0A2S5B4K1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_5072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4K1"/>
    <dbReference type="STRING" id="741276.A0A2S5B4K1"/>
    <dbReference type="OrthoDB" id="5876637at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY71712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="346" mass="36956" checksum="DBF9FDFC8D059D28" modified="2018-07-18" version="1">MPHKRQKRSVRLETQKAIGYNNPPTAADSLLPIQSTSKDGSGATGDAVLAPVKSNKRRKRSHSAAGGAAPSTDYGGVSKSAFRILNAVKLREDYHAQKKRRAEEQAKTDKAANKPVQPALTPLPHESLSSFNRRVEQAMRGSVRAAIKESSMTGQKKKDRKGKGKKTDEEGGEGGDDEIAEEDAAPVKRGRDGKPLLKKGTKATPEDSVDPFAKRKKRPAADGDVGDAADPPGPNAPRNITGKTEFDTLSQRRRIGDVVQAPPTLADPARKGLMAKVLGPGGAAACGVPPPSAGGTFRLAGAEAPVGSSRLPINPAMKAMMDAERERAVKTYRELKEQREQEKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4T6</accession>
    <name>A0A2S5B4T6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Laccase</fullName>
            <ecNumber evidence="7">1.10.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4T6"/>
    <dbReference type="STRING" id="741276.A0A2S5B4T6"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="191" mass="21051" checksum="DB466B139C6D9F10" modified="2018-07-18" version="1">MSGLLRAYNSALIRRPYATGMCSAAVLFGAGDVLAQQGIEKKGMNHDIMRTVRLSAYGGLVFAPLITRVYGGIDRIRFSSKFATTAARVAVDQFLLTPCVLTIFFTCQSLLELKGFSEAKRRMETSFFPTLTTNWSVWIPVQAINFSIVPVHLRLLSVNVVSLFWNAYLSYANAKSASPEPEIKQAMGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4U1</accession>
    <name>A0A2S5B4U1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_5155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B4U1"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nrap protein" evidence="6">
        <location>
            <begin position="289"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="446"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="627"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="798"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="999"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="1171"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY71794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1319" mass="142480" checksum="FB8E9B35548686AE" modified="2018-07-18" version="1">MAAASKRAATSAPARPAPSKKARPAQSAPPVDSQQSEDDDELDLAASDDESLGSGFEDLEQSGDEDGTSEDEFAAGQDLEGESDGDQMISDDGEDLYANLDDDDDDDDDAMDSELGESSGDEPVAVGAPAAADDDDDGGWETVGTAPSAPLIAPAAELEKRKRAKVPKLSAAELRALAFAELTASPISNVLATRVAALLDPLTPAPSTSSPMQPVLKELHAALTGVSKQKPTSLDALRKKGRVVPKAEGTDGKWAKLELAWEAPRSEDIRVIGNWAWGGAIKQKGEYFVDIAVAMPAALLQPKDCLAPRWSAKATHYLVTLAQHLPPSLGPVQLSYAPLGQGHCLEIRSALPKGESKVGLSKAKGAVLRVRVVTPEGVFADAKTSPTTNLARPPSLASAFEGNNPQVDPSTLPLTPLHSTALHLSSLPLQTAHLRYLHSLSTSFPAFTSSVRLLQTWAIRRGYAASLGLSTDWWAWCVARSLNAGGKIAGGDSASLAAGGEGWAGWRKAIEWLSTANWTEGVWLKSSEEKYTKADFKRAFAGRPIFVDPTGSVNLAAGIELSTLEMLKYDAREVISVLLANIEDERKFDSAFNREIQPTERFDNFVRWVFFETVAAMIVLPASPAVDADAAVDFADPFAYLTSAMCATLKRALGSRVRNFAVSPAPLPATPVEGKAAKPSTTRTLSIGFILDPVDSLRLVDQGPSAEDDEACADFRAFWGAKSELRRFQDGAIVESVVWDEVGSNGLGQQRTTIVRRVVEYILQERHGVPLDNISFFAGAFDHLLVEPEAVRRSIYLEDSVVSGKGFSNIISAFDDLAKEIKDLPDLPLTVSAVHPCAPGLRYSSPFIPSPRRLKDYARLPLSLKYLDAHDIILTFEGSGRWPDDLEGIQKIKAAFLSKLGEGLEATRAVLRAELVFSTDSRPIDDNVALEILTASGWAFRARVFYDRSQTLLEEREDQLGAAAAAPSDDVLSSLDLYLERFVHAPKHHAAISALQNHFPSFSPTVRLLKRWISAHLLSAHFVPEQLELLVASVFLDSASPFGIPNSGATGFARVIERLASWKWRDEPALVPIYTFTTAITSGRRANLPTAERAEVVASFQARRLSRPSIDTHAWVIATENDLEGVVWGRRTSKVAAARVRSLAIATLATLRRGVLEGDLVVEQLFSPPMGDYAFLIHLDPSAIPRHFQALAADPAALSSRQRSSVLSGSLMGGLEDEDEEIRIGWDPVAAFVEDLRTTYGSVFLLFHSEHGAPTIGAIWNPAAEAPKAFKVGLGYPIKPVRDDDGGKAKVVLDKKAVYREIERLGKGLVSKVDEVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4V6</accession>
    <name>A0A2S5B4V6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4V6"/>
    <dbReference type="STRING" id="741276.A0A2S5B4V6"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="6">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="253" mass="27508" checksum="9843BB67628547B7" modified="2018-07-18" version="1">MSLISLWVSSPDTHSERRLGLDLTVHQLKLKLEPITGIPLGAQTISLRRTATGAAADHPGQLVALLDQDSKTLADYGAQEYMTIRVESSDPHARGLAGQFTDDSQVEKFELTPEEYAARGDTVLAWKMRNQIGRFAPPAPATSDPGLAPTLPADLVPGARCQVALSDELSRRGTVRFVGPTEFGAKDGSVWVGVEWDEPVGKNDGAVEGQRYFQTGPQRASFVRPDKVTVGDFPELDPFADDDDEGEDEEMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4X7</accession>
    <name>A0A2S5B4X7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4X7"/>
    <dbReference type="STRING" id="741276.A0A2S5B4X7"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="433" mass="47747" checksum="78DE331D1CFA6D5A" modified="2018-07-18" version="1">MSYNNVGLSTPRGSGTSGHIQANRSALRQRDRPRDAHGSADDLRKQSFASRAPDQAILEHERKRAVEVKCYELQVSLEDDGVQQDEIDSQVAALRERLLAAASTSTNTAGQIKPHERHQLAQAKQEADSRMRRALGIKDDFVEGAAFDRDLQQQLKLERQAERERAREERNKIEQELKADRERALQARDAQRRKHDDEMARERRRQQDELEQSRRDHAVRMRSVVPAALRRSRLATGARPPSVSVAAPSRRLVRLGRPPPRPSLLGRLAVAVAFPIPLSPSVSVAAASRWFLRAPRLAVTAAASEAVPLPAPPPRLVLAVAVPAAGQEETVLAVEVAESFAAEESPLAVAFVRFEVAVSAAAAPPSRQREPAASSSRRRESEQESRRRESEQESLPVPVPVSVDEHERQPAEVSGSASERSARGGRSLCVKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B577</accession>
    <name>A0A2S5B577_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000065">
        <property type="protein sequence ID" value="POY71933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B577"/>
    <dbReference type="STRING" id="741276.A0A2S5B577"/>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="440" mass="49865" checksum="15C1C4F5B62AC27D" modified="2018-07-18" version="1" fragment="single">LLQGEVYKSDAGEVTRKSQICENPRAVQSRRRNRNPRTARICSRLAIPNSICCCSQLALFFGPKKNMGEMTRGFQDRDCKAAVVAPVHSRTPADTAYSAPSKMPASRRLPPELVSLIVTRTGDWELAHALGVRTSLPTPPPWLEFATPLDRAILRSGQAYSDGDGDGDGTVPVRYARAHGHTQFTQWGARVMLRFALVHTIEELFRVDESQFRRQCEHLLPVVASAWGRRNVLEWAKESEFKLNPDPRIMAEAIDEASRHGQVEMLDFWLNSGLPLHYSDAALLSATFMGQVGVLEWWKKSGLPLKIGNVLDFASMEGTTVCLDWWKNSGLPVRYSKAALYTLSKTGNLALLSWWLASGYTLSYDKEVLVIATRYGHVDVLEWWARSGLDNLEFRFFDIEEALEDSVANKEETQKWWERRGYDTAMGANQWMRLRNLNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B582</accession>
    <name>A0A2S5B582_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000065">
        <property type="protein sequence ID" value="POY71939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B582"/>
    <dbReference type="STRING" id="741276.A0A2S5B582"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="52"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="283" mass="31843" checksum="082BAE3B6BED582C" modified="2018-07-18" version="1">MSEPAHTAFAKSNFSKSGSSGLYDRARPDYPSEAIDQILSRLAAGSNSTVVELGAGTGLFTRGFLERAQQPSNAGKVARLVAVEPSEGMRQGFMNKLDQSQGTIRVECEDGLFDQIPVEDASADLVVIAQAFHWVGHDGRSAVKEIARVLKPGGTWALIWNLENRDVEWIAQIREKYERFEQDTPQYRLGYWRSIYDTTEYESAFTLPTESHYTRALPTTEDLVVDRAFSKSYITALSDAERDTLGNEIREVVRKGDGKRWIDKDQGVFEYDYKTDLVLAQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5M9</accession>
    <name>A0A2S5B5M9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BMF94_4884</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="PJQD01000059">
        <property type="protein sequence ID" value="POY72077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5M9"/>
    <dbReference type="STRING" id="741276.A0A2S5B5M9"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="POY72077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="504" mass="56197" checksum="620F15A11579CF41" modified="2018-07-18" version="1">MFAVPPPPSQDGPAARSDRSSRFTDLDSAAPAVATVQKSDSLAQFLWNNPTAVLTDHDRCFDLVAAAVLAGETVLCAAVVRYIPYTEIDFSTYLQQAQAFLDGERDYAMLKGESGPANYPALHIYLYSALSWLTDRGKHLERAQWAFAGVYLATLAVVLFGVYRRNRRIPPYVLPLLSISKRLHSIYMLRMFNDCVVMLLVYAALLLYMIPAPSISSSDPQAGRVAKRRVEQRWLLGTALLSCALSIKMSTLLFLPALFYLVFVHFSPLALLQHVLVLLTTQVLLAAPFLSTAEYRSRYLAQAFDFGRAFEWEFTVNWRWLGEEAFVNPSWPQFLLGAHAVGLLVWGSKWAEEDGGMERLLRRAVAKPTARPAMGKALASSRIATMFFCANLTGVVCARSLHPQFYAWFAHSLVWMCWGTSCAFEPMHCLVIISLVEYGFSVWPSTVNSSLGLVLSLVILLFGVYYGDSIRSNGTAPPTPAADRPEDIVVPPERSRRSDEKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5T2</accession>
    <name>A0A2S5B5T2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5T2"/>
    <dbReference type="STRING" id="741276.A0A2S5B5T2"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044520">
        <property type="entry name" value="ARF_GAP_AGD5/15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46419">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46419:SF2">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="561"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="843"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="913"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="963" mass="101250" checksum="09E530B34E01FDEC" modified="2018-07-18" version="1">MSSKAAAADRYQRQILALVKEPGNDQCADCRARNPRWASWDQGVFLCVQCASMHRKLGTHVSKVKSLTLDTWNREQVDNMRSLGNVRVNSFLNPDERRHPPPAAESGDERNSELERFVRNKYEYRVFAAEAGNLDSAPASTPSATLRYAPPPGPPPPPLRVTTDHVVGSAPLSPTSPPPPSYGQAAFDPTGPPLPARPAAVTATTSPASSPFAPSPSVTAQQQQQQRTNSPFANLTTTAAAAAVPSPGPTLPPRVPTAVPSGPRSVHFPEVPPTYIPSPPDSDEDDDDDDGENGSHSAQRPPLQRSSTLRPPTKGILRRRPNGGDEILVDWAALTSSAVDYGGDDDDEDVPLGQLGALGARGAQVGMMGVATMPTYPGAPMQYQTMYGTNQAPGQGPGQGWMAHQHLAVPYGAPGGQSTGGGVPIAASPQQQQQQQQQQRMPAVAPLQPQYTGSAKGYLHQQRQQQQQQQQMPAVAPLQPQFTGSAKGYLHQQRQQQQEPQGAQGGGGGGSNGMESFQQMFQPPNQNTNYGGGAASAIDTNPFRSHLFHRNQYSPSPQPPYQQSQPLQQQQQSQYQQSHPQQQQQQQFQAQAQAQQTAGSANDIWADLNFLDLGGPSGGAPSGGNGTAQSSSSHQAPAPLRPQLTGFVPSSSFGQQLARETATSSPAPYANGSSNQQQQQQPPPSLTLQIPGNGFGSHSGSSSPAPFGNSPAVGPSAGPSRSPMNDSPAPLRPQLTGFVPSSSFGQELARSSGYNGGPSSSTPAMSNGGGAGGGGGGGGGGGTMHAPQPLKPQRTGFVPSSRFGLELAKESGGGETFGFSSASGTSTPSGAAANESAPFDLSPTTPTAPQQQQQQPHPGKDAFANFSSSFNNALPPPSQPQQQHRFAQQQYAQPTGMPPKTNPFLRPQLTGYMPQQQPLPSQPMQPQLTGFTDGGHGQPRQTNPFLAFAGVGAQQQQQQQGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5U6</accession>
    <name>A0A2S5B5U6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-methylacyl-CoA racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5U6"/>
    <dbReference type="STRING" id="741276.A0A2S5B5U6"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="42125" checksum="32BCE53B7257C07C" modified="2018-07-18" version="1">MLGSDHRPLTGLRVLELAGLAPAPFAGLVLADFGADVVRVDRTGVNSSPDTLTRGKRSLAVSLKSPEGIAVLQKLLGPADDSGAWRADVLIDPFRPGVLERLGLDPQELMKRNPRLIVARLTGFRRQGPYSQMAGHDINYLALSGVLSMLGRKGDKPYAPANTLADFAGGGLMAVVGILAAVLERQGSGKGQLVETDMVTGTRYASIFPLTVSHPGAKLPMWDRPRGENALDGGAPWYDVYERIFVAALPADLCQEGKPEAQHQLDRDTWPDLATFLARGFLTKPRDEWTALFLGTDACCVPVLGPLEVDKAGRGPNEPQHESSAEARSGLSDFPLPAPRLTRTPATAPAGNGLFLQPGRHSLDVLEKAGYSAQQVDDLLRTEAVGNGRGRSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5V1</accession>
    <name>A0A2S5B5V1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5V1"/>
    <dbReference type="STRING" id="741276.A0A2S5B5V1"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="84"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="197" mass="21252" checksum="353160383874FAFD" modified="2018-07-18" version="1">MSTESESSQKAPLAPGMVIGPDGKPCRSCTAFRSFAGMHKKKKPAGTSDGSAAAGAGGFAAATALAMTTAPTVETDPPRLPADCPPDVERLGRHTWTFLHTTVSYFAPQPTPHQKSSMLGLLNALPTLYPCGSCAGHLRDYMKSDPPERAVEQGREALELWLCKVHNEVNQRLGKDEFDCATVPQRWREGWPDGRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6B3</accession>
    <name>A0A2S5B6B3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6B3"/>
    <dbReference type="STRING" id="741276.A0A2S5B6B3"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30240" checksum="A172A5770343965D" modified="2018-07-18" version="1">MATVSFPRGHKEAWATVTEPANGVWLIEMHNLPDNRLLPEVIRQALLPALDYVELAWHKAVKAGTNKGGALVLTGERKVGKFFSNGLQLECLAEYPTFFRDYYYKLLARVMTFPITTISAINGHCFAGGLCLALACDWRFCRPDRTWLCMNELQFGAPLPPGMAAVMQARLSEPTMRRVMLTAHRYTAPDALAAGLIDGIVPENGSEATIRYAITKATEMAPLAESGVLRAMKETMYAPALTMLARHEPPSVGMPQKENAFAFKALLAAEVNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6C8</accession>
    <name>A0A2S5B6C8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4629</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6C8"/>
    <dbReference type="STRING" id="741276.A0A2S5B6C8"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="12">
        <location>
            <begin position="221"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="335" mass="37293" checksum="FC6362EEC0F58ACA" modified="2018-07-18" version="1">MATTSFAPRPPIALSMPGTPRNNGSTPRSARRLQSTPSSRLSFGGNALALAQASALAPLPPINSRVYPDKSYADDDELRDLIERDKVAVDDAVQILGHALAHTRKRLVESLEEIAAEHKRLERLTRELGDAAKDMVKTVQREKDEMDKARQLENEVQTRSRSLAVQVEAATGEVKEIHAKLHARRDLKARQRAAFSKQVARNGPELAFLERKLGLSVRGTAPDVVRFSFHNIDPASFPRTFSLDLDASKSQYTVASVTPASFLPSSTLGPLLAQLNSSRNLYRFVLAVRLALVDEVVLEKRSFASEVEREKERKRVRDARERRRDAGGDEYELAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6M7</accession>
    <name>A0A2S5B6M7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6M7"/>
    <dbReference type="STRING" id="741276.A0A2S5B6M7"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="393" mass="44452" checksum="ACE2ABA047213C3C" modified="2018-07-18" version="1">MLADDPIASPQEDRPTVLANGERPEAESDGRTCRICFCDGDDEDGRLIAPCRCSGTARYVHQGCLRSWREADRKNSFYACTQCGQKYRFRSSGAAKFLNHRYAPWAICAVLLLVFGFLASFLADATMEYTERDRLLRSDRLAYSLINHRALGDGLRELSSTAGTLAGDCRWSSALEKHWTVKNETLTWQDRTEWVMMSHLSERNLTSCGRLWNADADEQVRAGASLTFILRWLRGVALIGLLEAFVGNARELLSNKSSLSGLTERLSELTLRLPDRLYIVVNLGIRMHRPRWIPEPNVPTIRYVPPLLAAFCMDFLTWIRLSLKRARRADRLFAPLQLVAVLVTAVSIGFAGHLAFVLSKWLVKKGLSRIEDLVQDFDSDDPRERGVAREKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6N5</accession>
    <name>A0A2S5B6N5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFP11/STIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6N5"/>
    <dbReference type="STRING" id="741276.A0A2S5B6N5"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="8">
        <location>
            <begin position="432"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1048"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1061"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1161" mass="124288" checksum="1415A2EBED5B7982" modified="2018-07-18" version="1">MARRKKQFMDDGSSSSGDDDSANLDDESYFDPNDPDVAAERELFRNPYGAHRGKKRTRQELQEDATYGVWAQQDDDNDAGSRRGGLGGGGPASTSRGGRGGRGGQQRRADYQKPVSFVAAGQPKGAKAEEPIDNLSTALGIEAAKEDEEDVAMELGNSSDDQDDAEELRAAEDIAADQLEAEEDEDRAEEPDEDGDLPPVPGLARPPSPSPPVPTDSGPTSSLAFAPRGIGARPGIGRGGIGAAGGARGGLGSAARGGIGSGASALRPGLGAFAAATSASAGEASRGGIGAQPPRPAAATVESGTASPIDRASTPHAGIGAAGTGRGGIGARPNQSLVDSLRAELAGPAPGSPSETVTESLASSSAGASRTASPAPPPRTAGVAPTGTSDSSTTPREKRSFLPAPPKPPGSAAPKPKLSKSESVHFARLASSGSIGMKMLEKMGWQTGSGLGREGQGIVTPIGEGQKMRGKNEGIRAGERSKGALLEEQRRRGNAGAGSDDDEAGDDATRAAAAAAKKHKKHASAWQSSKPKKEKKEKTQFKTYEEIVAESGSAAEVQQELLVDLNGQALPNQSLSSLPAFGAGSADPTRLPELRHNLTLLCSTLSSSLRALAKEGAGVEQRRAYLAKEENRVRHLVEAQERKITSMQGVLACVERIREKEVEAMDLLRTLEAHSEEPVRAEDVLGRFEDDFDKLLGEFAGEYEELGLDEVVVGAIAPILRRLWQSWDPLTAPAHTVSQLKQFRKLFLIDKHTAPSRTAVSIDLDVYAQAVRAEEDAEIRRRQGERQMTPYETLMWTVWLPKIRSSINNSWSPSNPHPAVQLYTSWLPLLPAFVRDNILDQLILPKVSSAIAEWSPSAAKRETAPQLHTLVFPWLEHAGARMGMVMEESKRKIRAWLKSWKAKEGVPKGIAPWRDAFSKSDWDSLLLKHVLPQLGALLRTALVINPRQQDMSPVDAVLAWQPLLRSSMLSQLLEAEFFPKWGDALWIWLTSDGVNFEQVAEWYSWWKSYFADDVVALSGVSRGFRKGLDLMNQAMALGDDAKYRLSKPDFTPKHARPPTPSDGRTPTRRSTSSRPQVAAAPIADDITFRSIVEEMAAAANLVFLPTGKVAPQGQPLFRLSRTIEGKGGVTVYLEDDVVWIADKAGEFNPVSVEEMVKRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B700</accession>
    <name>A0A2S5B700_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_4351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B700"/>
    <dbReference type="STRING" id="741276.A0A2S5B700"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="123"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY72525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="173" mass="19612" checksum="882505D9E9A10627" modified="2018-07-18" version="1">MAAAAPAKVKLSTSEGEEFEVENDVAVRSVLIKNMLEGKSPSVLRHVGESDQAIPLPNVSANVLKKVLEWCEHHKKDPEPLAEDQDDTRRKTTEISDWDAKFIQVDQEMLFEIILAANYLDIKPLLDVGCKTVANMIKGKQPEEIRKLFNIVNDFTPEEEAQIKKENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B760</accession>
    <name>A0A2S5B760_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_4438</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B760"/>
    <dbReference type="STRING" id="741276.A0A2S5B760"/>
    <dbReference type="OrthoDB" id="2527248at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY72610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="479" mass="51457" checksum="BA16CBA9E8F89025" modified="2018-07-18" version="1">MQATSLSDAALLRRSSLAAVVEENPNPSAPTTSAVRDTVDRRHHQDNFGYSTDARVNPYMAPTRPESHFGTDRPSLADWGHAPSAPVQGSSRWTPASVGDNRPISVPLPSYAYDRGSPFSHSRPDHQQHSQQPQPVAGSSSSSSSPHPYLGMSRLQQQWAKAPATQYQPYRMSIAPEPARASGGGESDREHPRMQPPSFAHYQPEPSAPLLPPPSSYPYSSGSHPPAHSNSAYTQPLSLTLPPLANSFPSEPFALTSTYPPPASSNGNHYRHYSNGQASNDAGEQVEHSSNGHEQPSGLTESYGSARQSGPLSISLPRANNADPASYAESLAAAVPPGNAQPNSRKRKEPKDAASRKYACNECEQKFARPSALATHILTHTREKPFVCMTCSRGFAVMSNLRRHCRVRSHALAPSQESNAKRIGEYGSEMTGADKGDVDDNLDNAASAAGEIPLRPLPLAPSENTPTAFTLPAQSLYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7B3</accession>
    <name>A0A2S5B7B3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7B3"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="344" mass="36965" checksum="65198E612478DA09" modified="2018-07-18" version="1">MSTPPSSPELVRDALMPLAPSAKVDGHPLALDAGADTGALLRCIREQQSELLFLKSELAKSDEAHWAVQRVRQLEEELSDVQAGLAQAMEELKEEYELEQEDRLAAYTEVKTKLAAAESANKQLAFELEGAAKRQAQLKYDIQCYKSYAEQIYATGVKEFEQLREHACREWEALLLQKNELQGQRDQLASVLQDPQALVALQSYGALVAQGVGSQVEQPADPIEMDWEIEDPPPIVPATPFAPPVEPSFAPRLPASVPAQYGPGLTGLPVPPIPAPSPMAPDAFSCFATEPPGGAVNGGVGSSGSATGGTAAPPQGATRNFSQLSDRSGVKKRLEARKKAYGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7F9</accession>
    <name>A0A2S5B7F9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7F9"/>
    <dbReference type="STRING" id="741276.A0A2S5B7F9"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="455"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="606" mass="65495" checksum="564843155E75C2DE" modified="2018-07-18" version="1">MTSQYMPAYYQEPRNDNLSLAGIGTRAFGGRGGYAQAPPPPVRRFVPPPPAPRRPTPPGVYSHGQAPATYAPPPTVYAQPPARRISPPARDPYQETAHFAERPAEPQYIKCSSCSEQVEVEELGDHVCQPGRNLRSLRVDVAVDQNQDWNRAGSATLRVTNPDDERLHGTEPPPRSPAPNSAASSSRLPFFERYQQRVETSGSNNEAAAAAGQTGSAIPRSPRLALANLAPPSPGGHQSPQKTMPTSRSEPLLSIPAATSSYPARQGSLPSASPASYGRFPDPAQPSTDDPPTPPRTRTRAELVESTYLAYASLDDSDDEEPHPQDPRQVSHVPRGIPQSRSSPAGLSNTVANLDACLADLQLLADDHDDVQAEEGPAGLMLRGFDARKEGDRPADRRQPTPRSRSPPPTSMTLPPPAAQACTNCRLSLRDTGELRRAGDGQPFCRACFAERYLPKCRKCRGPIEGGAVSSSDGKITGKYHSECFRCFECAASFPDGEFYVYDGKPYCQHDYHALNGSLCAADACGKPVEGGCVSLAGEENGDGGRYHPACFVCSDRSCRLPLLDYHFILGGRPYCESHAIPPSHSYSSSTYAERAKKRQTLLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7J5</accession>
    <name>A0A2S5B7J5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BMF94_4144</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7J5"/>
    <dbReference type="STRING" id="741276.A0A2S5B7J5"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="405"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="POY72737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="931" mass="99160" checksum="A0309230C7EC359A" modified="2018-07-18" version="1">MAGPPYAPRRDDLAGGGAQSSADLYASVPLNDGAYPPIRSITPQTPQVVQPHYAAAPLPASNSSLPRPPSYLAQHGRSDSTHSDYSARDPFRASVPSTRPGTSASYAIAGGMYDSPDPALHGQSGRYSPSEQGSQYGAGGGGAASSEWGSSANLNQIMYRNGPAGAQAGRSDSYLGKEAFEGGAAAAGGLGALGAARDGRSQLRKKGYDAADYDPLNSPRRGARGWWARKSTLAKWLIALAALLVLIAAIAIPVGVVTSRNNADSGKNKINSATSSNDGAPPGIPTEQTPPADWHNAAAGGNGSVVYLADGSNFTYINNFGGYWVSTPFNNSARAQADVPALNETWDYNVHRISGVNIGGWLVLEPFIVPAMFELFNSPTEYANPNSTANPAIDEWTLSQQLGSNLTNAMTEHYETFITEKDFAEIAGAGLNWVRIPFGWWAIETWDGEPFLQGVSWTYLLKAIEWARKYGLRINLDFHAVPGSQNGYNHSGKQGSINFLAGVMGVANAQRTLDYIRTITEFISQDQYKHVVPMFSVLNEPYATSIGMDPLRSFYLETYNQMRAITGLGAGKGPFIGFHDGFSSLSVPVAAGGWNGFLNGWDRVAIDSHRYLCFSAPNTWGLDYQASLPCNYWAEPLNASTLQFGLTLGGEWSLAINDCGKWLNNVGNGNRYDGTYYVPGTTYPPGFAAVGDCSSWNNWQAWNQTRKDGLRMVAEAHMDALKHFFFWTWKTGYSSTFGDVANPMWNYQLGLKEGWVPSNPRTAVGVCPSLAAGQGMAYTSLPAPTLSAWMTGGSGAGTIINQTMSAQYSQWPPATIGAATSTGPYLTPVSNLPTYTQTASIVTMSAPPQPTSFPSGVNSSSVDVGTGWVQPTDSSSFYTAAAGCSYPNPWSGAAVPIPTTAFCGGAGARVKRDLKPSPTVVSRITPPPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7M9</accession>
    <name>A0A2S5B7M9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7M9"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="97"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="580" mass="63712" checksum="B54283E48F976695" modified="2018-07-18" version="1">MPFAATLTPEQKDTALHADDPALAPSMDMSDMENKKASSDIDVRHLESLKVSDDELVGSLTYNQLSLYEKKSVLINRELDHMNAASRGGLGRYQWCIFFLCGFGYFLDLCWAQVFGLVAGQIQQELDVPNNEIGNLSVLFSAGMTVGALFWGLAVDIIGRRWAFNLTCLISSVFGLIFAAPSNFGALCFLTFCIGLGVGGNIPIDATITLEFLPTNRRFLLCALSTFQPIGVVIASLIAWGLVPKYACDTALPSCKTGQTPCCGRSNNMGWRYTIICIGALTLFIFVARFVIFTFYESPKFLLAKGHDEEAIDVLNKIAAFNKQPAPTLTINDFRLLDKEYSETHSVHSDDPLHEGQKPLNTKELTKTRLQQLAGQFKHLKGLFANKRSIWTTVTLWIAYMALFWSFSTAGGYIPLILRQKGIDTEQTLNETYVGYIEIYTPGISATILGSFLMEIPRLGRRWAMVLSAALMGVSFFLYAPVSSFKAYTGISLLEYWAQSLYAALLYGITPEFFAAPYRGSGSGIASMLGRLAGTVAPRAAGTFFNPQSNSVLYMAGGAAFVSMIAIGCVPFETKGRHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7N8</accession>
    <name>A0A2S5B7N8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7N8"/>
    <dbReference type="STRING" id="741276.A0A2S5B7N8"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41470" checksum="56C6DA7A115D3EF3" modified="2018-07-18" version="1">MNSQQFNTTLSCFFITFPANFIMKKFRRPSRWLGLVTTTWAIVMTLMGVVQSYGGLLAARLALGVAEAGLFPGVIFYLSVWYPRHRSQSRVAVFFGAATLAGAFSGLLAYGIGFMGGLGGYAGWRWIFILEGLGTFVIGVASFWIIADFPADCKWLTEEEKEWLIYQKAIDSGAHGETSTVSIRYIKQALCDWQTYLSIWFYMGVNVPVYAIALISPSMIASFGHFTRPQVRDAVACCFVIFNAIMADRQKTRFKWIMIDMVLIFIGLTINLTPAPYGVKYMGLFFIASGACTSSSKVGALMLSFSSGAFQIGIGNLDGVMLAFNVGGLIAAPLYAYLLRRANRRKLAELQSGREYTPDEIRELGDKAPGFVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8B7</accession>
    <name>A0A2S5B8B7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_3860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000042">
        <property type="protein sequence ID" value="POY73022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8B7"/>
    <dbReference type="STRING" id="741276.A0A2S5B8B7"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="408"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="859"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="901"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY73022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1023" mass="110959" checksum="7CF8AF68CE536495" modified="2018-07-18" version="1">MNGIGQEQSEGLLAPLKTGAQLPVPSSSSPLASTSTTPTTTTVAPELEVAALAGDEFTSEADWLNAVIAASLGTDTVEEAPLAQVEASLTRTLHTLDASVADTSALVDRLITDISLSVPRLTFDLQLMRENALLLRFTLDGIRKRGGGFGTESEVGQVLERMRTLDLVKERMEAARDVLREAESWSTLESEVTGLVGEEQYIKAAERLAEAARSMVVFQNTAEYEARRALMVSLQNQLETSLSAGLVKAITDRDIKACKQFFGIFGMIQREQEFRVYYFSNRRRSLVDGWSAAKLSDCLELPQTLPTTGDGATMGPSMRLAAYLGSFYSDLQALLNEERTYVPAIFPDPKDTLSSFVETTLEGLNPSLPQRLTAIADYYGPIVLPELIAAFKATEEFAVQVERTFNKLDPPASAQTPAMTPASPAGPARGTFSNNGSTPAPAPSTPTKRRMSTRRTSSKKLSSRSISYAAGHGPDLSSEHGDDLADDVDAQIRPWETALFEPFLDWQVEYPELERRHTSSELVRALGDAGEWVAALAAGSSATGSEQGAKLLLDKSTKVFSVLEEAVGRNLALTHGYAARGLVDVLNDQLVNFFDQRKEDLVRAARSKGSAAARRKAQTTSAALANGLGDADDEQEMVLEGLEYSTEDWSTFQFGLKLLDACRGMADRLTSFESRLKSRMMALAQTLRDARLDPRYTIPGTTRGGILLLRQSTLNSAEMSELFTPFEKAIDNAAASHAAPLSMPLPFLLPKARGAAVDFTRNAQLFVHDTILAPLLSHLDEYAGLSCWSSAQDARSAGKGAFDLAIPTFSLSPTETISRVGEGLFNLPRLFEVYADDDALAFSIETLPFVDAEALRAMQQPPAAPSMTRQNSGHRSSPSDLLQQHNGLPLSSPGGQRTRRSSLAGSTQPHSQPAPVKLTAETVIATWLSSLTLSILTHLTSTILPNISRLSKHGANQLVSDLDYISNVARALDVESPEELEGWRDAAAMDEKALRGETETEARIDRSILERVARIRGLRRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8Y0</accession>
    <name>A0A2S5B8Y0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_3560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8Y0"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="429" mass="47216" checksum="0CD4A157315FD6D2" modified="2018-07-18" version="1">MSSSRRLMQSCLQCQNGTAWSRPPLQASRKRWLATEPAKESAPPTDAPTSPAPPRQQLESAQQSHAAADAPSGPRSSVQSASAQLAEARRLAHEQVQRLANTFNTSARKQANTIAASIHALELERRLKEVGGKINHATGYEEIERLRNDVGEKEKALLVARENAIRFKRAYTERVRLRADSQREVNDLLQRKATWTGPDVIRFTELVQKEHENDRAEKEAKEAMDGAEAEVEKGFSGMMQAILERYHEEQVWSDKIRSMSTYGSLAITSLNVLLFIISLLLIEPWRRRRLVENVEERLRNNTDAGHATTQAQLDTLHDLLRHAQATLDSVTATRLAHEGAVDPHQVAPLPTEAGFTETDDALSDTLLPPEELLVDEGPAEIASPSHRTRYEKAIDDLRGAVEGHEVLAAGAAGAAGGLALAALCGLMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B962</accession>
    <name>A0A2S5B962_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_3655</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B962"/>
    <dbReference type="STRING" id="741276.A0A2S5B962"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="99"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY73320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="319" mass="34985" checksum="DB0A5AC0C2C27D19" modified="2018-07-18" version="1">MSGRFQLFRQSLRQAQQAPSLARNASTAASQSAFTRATTSTRTAVALSLLSGGTFAWYSSLYGNPLLPEVKAESAADHGLHAPEYPWAHKGPFETFDHAAIRRGYQVYREVCSTCHSLDRVAWRNLVGVSHGVSEAKTMAEEVEYQDGPDAEGQMFQRPGKLSDYFPRPYDNEEAARAGNAGALPPDLSLITKARHGGADYVYALLTGYVDPPPGVEIREGLNYNPYFPGGAIGMARVLYDGLVEFEDGTPATTSQMAKDVTTFLAWASEPELDQRKKMGMQASIILTGLLAMSIWVKKFKWAGIKSRKLVYNPPSVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9G2</accession>
    <name>A0A2S5B9G2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9G2"/>
    <dbReference type="STRING" id="741276.A0A2S5B9G2"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="129"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="440"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="665" mass="72780" checksum="9AC02D91AECCF73A" modified="2018-07-18" version="1">MSRPDSPAPSSEDSGPSPAIMSTPAPSSTATATLDDDEVASASAYPFSADPYPQDEEAIKRHQARAAEREQEYNERQRAERATDGADHDAEAARNGVTSPPLPQVPGHDDDEDGATQQPRARQQRVYVRPARDAIQIVDALKTSEGASTPYIVYCIRFENREVRRRYSDFVSLRQALATLHPCFIVPPLPPKNTLSSYAVAATNPAKAKEDAALIARRRRMLSTFLNRTLLHPTLGQDRVFRRFLDPETPWHDVLHSPPVTLAPKNPLRAPAHDPTDPDMLALFANLPLPSSSATLSHPDQRFLDSEVFTNKFSTHLGGSMEKVNRRLMKRWHDAAGDWGEMGGGLNGFALRMGEDGSAGLDEATEKVGMAVDSGYTLTNTMASPPTRAREAVARARADLKPALPLQLSSWEQDFTEPLQEYTQFSNIIKGLLKYRHAKHLQYEAARELLESKRATLEELERSELEAQRLEKALERVRIVNDDGGSDRAVSPSNPSAADATGLIGAAAEGHAAGQSAPLPPLPSSSGALPSPPPARKGGGLVSALRHSVKGLVDSDPEATRRNSIGKTREQINQLDEAIKALTNDLRYASTTIQSDLDRFQRQKVGDIREMCLDFSKFHKDWAMKASLSDFGLLAAPCPKTARHDLQNLAMWEEAKAAIDAIADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9I5</accession>
    <name>A0A2S5B9I5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Oxoglutarate dehydrogenase (Succinyl-transferring)</fullName>
            <ecNumber evidence="6">1.2.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9I5"/>
    <dbReference type="STRING" id="741276.A0A2S5B9I5"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="626"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111458" checksum="9033CC88EECCF81A" modified="2018-07-18" version="1">MLRSYTRKLPLGGGATHRFPYRPTAISGTTTTSGRGIRSLHDRGIFGYQSPREFTVPDFTPAELENRVRNAALLRLVESYRRHGHRAALLDPLDLAQRPVVPALDPRRYGLGAATPSREEFVSETVPPTAASADPNAARKLDVTGILDFPQDGKGPERSVDEIAARLAEVYCGGVAYEFMHMPSKHERRFLETLLERSHGFPISSAEQRAQWELLAKSEGFDAWCAKRFPNVKRYGLEGGESMMTAVATVLAEAKQVGVDDVVVGMPHRGRLNLLTQLLDLDMRLLVRKMRGLPTLPPSLPASQFTDDVLSHLFLSTQYRPSSTDATASAASSDPMTVHLLPNPSHLETITPVALGFARGLQVPLGSLKAETSGEPYELGSKVLSVAIHGDAAFGGQGVVAETLNLASLPHFSAGGTIHLVVNNQLGYTTPAVQSRSSFYATDLAKMISAPILHVNGDKVDDVARAMKLALAYQQKFRKDVVIDLVVYRRRGHNELDEPGFTSPMMYSKIKDLPSIAKLYEQQLVSDSVISASEAEAFRKDHFASLDEALAAAGPEKFTPPELEMPRGWNEMRWPTEGEFKKQVETGFDPKVLREIGERSVQAVHPRLTKMHMAKRLQSIEKGEGLDFATAEALAFGSLLVEGYHVRLCGQDSGRGTFSQRHAILTDQKSERATVPLQTLRSTPLSSAKSAGECGTFEVVNSPLSEYAVVGFEQGVAWVTPKLLPIWEAQFGDFNNGAQIMLDTFLGSGETKWGMQSAMTLLLPHGYDGAGPEHSSARIERFLQLTNEPLSRERAFVPNMHLVNVTTAAQYFHLLRRQMKREYRKPLVVFSPKGILRLPAAASPLSDMSEGTTFQPVLTETVAEPNKVERVVLLSGKMYYDLAKQRSERKLDGRIVFVRIEASSRSFYRAAQSNGDTDEQGIVQEVSPFPHEAIVKAIKPFSSAKSVMWAQDEPENAGAWNFVQPRLQQIIPKSRKLQYVGREAMATPAPGVKLYFEEQRKATEEAIFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9P2</accession>
    <name>A0A2S5B9P2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_3432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9P2"/>
    <dbReference type="STRING" id="741276.A0A2S5B9P2"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="285" mass="31447" checksum="A663CE575BF8521F" modified="2018-07-18" version="1">MSWAGLKKAASRAGTQVSMKLGQVERTDDSAFRVEEDRFKVLDKNANALHKEAKAYLDAVRSVSASSTRIGNTLDLFFGTDSGEQAISANAYKRAVEELEGDIARSFVSLGGTAQGDDESGPRNPAVVLPWDAPYRATVLEPIGKFSVYLPEVNNALAKRQKKLLDYDAARSKARKLAEKDDPIKLRAAEAEEEQARAVYEALDAQLREELPQLLDLRVPYLDPSFECMVRLQSHFATDGYEKLGGVQRYFPEHVREEYASGALDAKVEGALQEMRELSICGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9W9</accession>
    <name>A0A2S5B9W9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9W9"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="290" mass="30333" checksum="B417442B6420AA3F" modified="2018-07-18" version="1">MTAINCVMLSARGDPIPLPGEKFLYNSTATVSISLFRRPEGADFSVQPRKGHEYKATGGTVYVSQRRIVYVAREAAVAGSSSSAGSGATAAIQLGSLAAGQASLAPDAQILAAPGKVQLATLSVPLRFYVDGHLVQPWLSANYVEALCITDNSADGLVGPHICRLHFKEGGAYEFYTAVEEVKARAELSGSRRDTPVEQLPAYTVDTSRVVAAPTASTPAATDSDSLAPPPRMIPPRTAPSPADLVAAETARAAEESERLQRERDEIPSTTQSAGVPAVQAGEAPPGYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA66</accession>
    <name>A0A2S5BA66_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA66"/>
    <dbReference type="STRING" id="741276.A0A2S5BA66"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="110"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="239"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="384" mass="41767" checksum="93F49C5EDB3D638A" modified="2018-07-18" version="1">MSTNPTASVFGTPALDSAACGVTAGIVSTICMQPLDLLKVQLQVSTAKKSQGALGQIWWGLGEIVKQGGAQGLYRGLTPNLVGNASSWGFYFLWYTMIKARMEDDKGAKLNAGQHLLASATSGVITAFLTNPIWVVKTRMFTTHASQERAYRGVWHGLTTLAREEGFRGMSKGMTLALIGVSNGAIQFMTYEEIKKRRVELRRKRLGAGASEEEIKRLGHLHITAKTELSPLAEQSNTEYILMSGSAKLVAIAITYPYQVIRSRIQYQPIPPPVQSTSAVHPSLATTAPFTSTSPSSSAPSTANAPSRTSAVLASALTDKPYTSIPDVIRRTYAREGLAGFYKGIATNAVRILPGTCVTFVVYEQMSRFLGRLAERRETERRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA73</accession>
    <name>A0A2S5BA73_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_3201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA73"/>
    <dbReference type="OrthoDB" id="18703at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31109">
        <property type="entry name" value="PROTEIN FAM207A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31109:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN SLX9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY73666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="238" mass="25788" checksum="514BA025DA41E0BE" modified="2018-07-18" version="1">MPRPTRARTSLPGHSRAAKLKPDSAGVTAPDGLDDSYMMAPEEMAPIAAVKAAAALSEPALQAAQESAFDAEEDETLREPKTKQTKAEKAYNKRKLLLDKLNASTTPYSKSHNRRLRRAARPQDNLVTTLQEVEAVLPSIEPAFDMPDEDEFVYEAEGGEGEEEATAAPGGPKAKTGGKGKEKLTAKKRQRVLTAESTRLPAIIKNESFAASPFATIRQHTLNTLAMQKNPSLPKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA77</accession>
    <name>A0A2S5BA77_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_3215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BA77"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PIPK" evidence="11">
        <location>
            <begin position="2059"/>
            <end position="2394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="412"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="551"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="971"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1047"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1543"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1599"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1712"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1934"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1047"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1606"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1655"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1714"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1760"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1789"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1828"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1862"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1892"/>
            <end position="1908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY73680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="2465" mass="269743" checksum="1244266A8D98B87E" modified="2018-07-18" version="1">MSASYESLPVPPPSSRSSSSASPTPTGTASAFSLTGLKRFFGGAGPSSRPNHHTQRERERRRDTIPEEDDYRPSVASQHLANVVAGLTGAGNSGEDSGRSLSFPSRSLRARSGSRTQQSAKGPGSGGSGVGGGELGRGSTGSRAGSEERTASSSRSRSRTRASSSDHVILPDGTRFVRPIRLSGASPSVRLTLQNAETATGLSSLAGQSGSYAGRGSSEFKFPPSNHQDDASPTFSEDFPHAQAGRPRRLSFTGLANFSGLAGRASRAADDDAVSVRSVGTGGGHAGTSAYELMKRIRNEGLSTRYWIKDESAKDCFQCGSTFTTFRRRHHCTCWLPPSEVCSCTHASLQVAFAGRSSAFPGTALLRLRILQAIPLADGSVLFSASTILPRFGNLQRVRVCDGCRPAAEKHESLRLSRTPTLEDDRASVTRYRSPSASHDMPLTPASSRFYRRSGSGRPRHSRLSTSNSLPGICDEDSPTTARSEYAQSPIDEESRAASRQAATSRRASLGGSENGEMELRPDRSPAGGDEPSSDILLSPALSTATAPFRRSLGDEDHDEPIGPSSTDATPHRSEEPSPSESPVLQGLGLYLEGGGDVSTDGGDHVEDHTVPALDRSGEDGEVTQRGVTFLPTQGIRGERRDRLALERSDSRLSGHLIETLPPASFDMSLVDPDIYHLDAFRAAEAAEVPMSAATLAHVRRSIRQALEREEVPVPDAWAPELESLLFDVSERLSMLDEVEVGKFALNDHVRVKRIPGGRPRDSEFVSGVVITKNLMDKTMPRQLSNPRIMLISFPLEYQRHDGQFLSLDKVATQEHEYLRNLILRVHGSFPHIILAERNVSQVALDLLRERGIVVARNVKGSAMDSIAHAFGAEKISSMNGLLDPRLGRCRSFRVQTFVNRQIPGGRKTFLRFEGDSHSSCTVVLRGGSMEVLAKIKKIIQSLVLVVYNAKLEGYLLHDEHLQARPSELDLAQAASPRAEEQQVTATSAAPRDSGAPDLALSFEPYDTAELTGSALVHYPPPYSLQRVAEDAERLRELRELRDAEEAQRILDEERTSLSTTTPTKEEPGDPLAELSSVDLLDAPLGTSPSAHSVPQRPRIEKGLDRPEDLARQALVDEAEASQARHLADWAAYSKKSHETFDLRDHQQLFVLESLVLYRTDGEPSRLCRLPEVRTIDFYRETDTTIGQYLREVNESLTKDEPCPSPSCHEPLHQHIRVLVHDRVVLRIAWHAWDNSVLQGAIGLSSACRRDGCRCTSRLVRASAETARLSLAKFFDLSFHPSTVFQCLDERCRHDGQADHVRFWHYGDVRVSISMDYIDLRDIVPPPRRLRVRPDRQVELRNAEYEQVARRTQAFFDSVQNRISSFKLDYVPPEREEECQEGLDAFSKRCEAERRGIQGLLQSTYEQAHHSNGTDMIDVRRALQERSLSFDSDWATFVKRVVPSELPDFRRASSQLKRIFPEAPASVTPSSRIVSTPLLPAIEVDEPFDGAEPPPPSPLPVDPVDPVPAPAEHAAEVLEAVGGDTTHPDADIVLVSPAVGAPQSDELPFSHPFSLSRSNSARKRRESSSSEAGSDTTVCADGEQTSTLTWTHHPELRHSAAPSAEHAADSARESQRRPPRRRIGPQIAALAKAYDQSASSQDACGSEGRPFVRRSVTDRPADSQERRPHARMVGVPHLSRQPSLAVAAARPTRLPLRKPAANLALARMFDGETSSRASLPSHSSRGRLASPDASRASSRSRGSSRAVSPTSTREAGYPGSKNSRPSIQRASSSRSTIKVRPSKGAGPGSESSDARSTSANKSVRGHALVRTGSGRGIARRSVSGRTIEGLRRRFEAEQSRPDRRNGLRKQARPVITSQPTHRVFDNIRDAIKADSDDDEDMRDDSSSIDESGGADDEFDTENEVSDAEEAGHAISDIHGNELVEAAIPPVLERAPSSSMSHALVQSHHAGADKAGASSTEPESARDPGEVVSVAASPAGTDVSTFPRISEGESSGTERRSLFDTLTSLWNFRNGDFAPLAYPTLPTEHLYVNNPILLRDDEPTSIIAHALCSRKYYSAFETTQLPRVQSGLANGGIGKEQPSQEPDAPSTAHVAEAILRGSSQRSFKLGDVELGDISARCTVFWAEQFEALRQQCGCGVQFVESLARCFRWDAVGGKSKVDFMKTLDDRFIVKQLSRPEMEVFARFAPAYFEYMADALFGTRPTVLAKVFGIYRISLGKQYRNVDFLVMENLFYGRELKQIFDLKGSTRNRRADENNPVLLDENLIDLSLKNPIYIREESKQLIKQAVWHDSRFLSDLSTLGNITLRFSLKLIRMGRSPPDVMDYSLVIGVDAQKAELVVGIVDYIRTYTWDKRLESWVKETAFLGGTYKAGGPTVITPKQYKTRFREAIDGYLLLSPTPWLDLAQMRRDPGETATRVAALTAGDTVAVTDQQSAVSQTPDIIHPAPAPPPSDSASIFEAALGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAK7</accession>
    <name>A0A2S5BAK7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAK7"/>
    <dbReference type="OrthoDB" id="2531353at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41471" checksum="4F02F1846C5BD7D5" modified="2018-07-18" version="1">MSSDVQPSVSRMPRQADLNCLPTEIKTHIARLCAQQDDRLREQCDELSRRYEPSRASIRGSIMRPSSIGCLFRASKEWSTIAAPFRFTVLSMRLLRREDFYHETFHTLNFEARSYEHRTSMDILVKLAGVLPLLPNLRTVKLVDFNAIFSHAESAEIPAFSKVCKLMGQATTLTLGTESSAISSEAVCSDLQEIGHFPNLTSLHLNVQSRVLPDMAEALKCMSNLLSLDLVLRGEDETADEACEIAAACLRDEYGFAPNEINPALRHLSFDFYDSSTSVIDLVSTFRASLVHLDLCARKNVLDPDDTGTLADDFPELETLTVRGDVRAFTSLLKSLEPDDFPRLGEIRYLPPKYPQVGGPSAAPVRVAPDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAM1</accession>
    <name>A0A2S5BAM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAM1"/>
    <dbReference type="OrthoDB" id="3256367at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="455" mass="50699" checksum="4635FD1F0E1CB0FF" modified="2018-07-18" version="1">MDFDAEQPSTPARRRVDLNCLPANVKTHIARLCAKQDRALKDGLSFLHQTERGTLADLIASFERDKRGASIRGLYCASKEWSSIAAPFRFNSLDVKGLRSPVFQMRLAHTHGQHFREVKLLGAKLCDFIILAPLLPFLPNVTKIWVSDFRPAALRLLDPIELDERELTHLETTITAILTRAEHIVAHVNATDVLPTLVPEAARSRLLRLSVILSDAAACSAFFDLLPSLALPPLRVLEVASPDVAPSLLDFMSLFAPTLEQIFFKAASYSLSFRPQIPTGSTSFVGPFPKLATLSLFGDAAALEGPLGGICDDNMPLLKTLVYFPDRLPAQPERRAGEPFIPAPHRIIPLQVLGVYTAEYPKDRTLLEKLPISSVPMAQQKLDRNFYEDVLWYSQSPAESPGDFDFADVEETDKDAIDYLRTWTERAKVQRDTASLVRIARALCQVELERIAYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAW2</accession>
    <name>A0A2S5BAW2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAW2"/>
    <dbReference type="STRING" id="741276.A0A2S5BAW2"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17110" checksum="B7B582C5953DF138" modified="2018-07-18" version="1">MLSLARPLARTSGLCLAQPARLSRRFPTSPVLRSFSMSASSAQKHNPWAEQLPKPADQLNSYLASLPDFAEGSKRMSIRPKHLEHAAEGFKLGWIVQAGATFADDSRTQMTGSWFLLREESLEKARARLAQDVYATDGAWDMSRATITPVAIAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB22</accession>
    <name>A0A2S5BB22_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY73976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB22"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="918"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="918"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="841"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="867"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY73976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="944" mass="100053" checksum="61E8F9E492A057C7" modified="2018-07-18" version="1">MSAYHGSYAPDEASLFDEQMSLAPSFSTSVDASGGADLATPMHDATAYGAGPSSNGPHGVGVFADPAAGMYRPPSTDGLYSAFQPTSLPAYSGVVAPFSQVYQDHRHLSPFGHFPPMPTASTSSASAPSVLSPAHAYPANFTTAPSVLAVQGMVHQQSRVQQHPGFLDPRQQVALLQQENDQGAGISLATITPRQVESFSVASTPTASVSPPPSSTSTARASKPSASTSRKVSGSADSTAKKPSATASSSAARTKRPPSASPAPSAYDPQEWLSLLPTIRANLTQKRLQTAALSTAPKLLKDLRLFSHEGSADSPWGDASDVPPDGRAEVLHHLLQYAKDEFWRVFLDVGKQASVKGKGKISSSAGDDPDGSIRSDALDLLQAWLEGASKSIVREKAQAGPTTEKDRKRKELEQATLVYVLKALAKLPLTYEHLISYKKVAKRVKVISDRAPEGGAVKGAATQLVAKWSKVQAAKVAETKNGSSAGAVPATAAKRKADTPDIPAKKAKTAAPPVKKPTPIPAAPKVALPKFQKAPAPAEPPRPAFMAALAGLQKPAASSSSAADDATVTKATAPKSSVAVKKKKKTVHWPKDDAKLCDYREIEAREMPESDAEEIGSENHHLMDQQEGQSLLQHFEEEVEMEAEIDWYTPINVEIPETDDFAALREPKQSLEVGVQTEREATTMEVEFDSSVESPGEGLVAEEEIVDDTSIKEIALHSSLADDGGIRLVIAQAQLSQADPGLPASNDQITALLGQLTTNGFAQTVEANEAVLPASLNPHQTPYGAGPQAQPSTNEIDAATLDALKQYNAADIAAIIQNVPSFQGLDLSAIGVGPASAPYPSAPHQAPLHDQPYNGYVPPPPQGGPPQGWAPYPGQQQQPPQGMGMYNGYQPPQQQQLGPPVPNFQPQHRAPRPHNPAKEKTVQCRFFRSPKGCDWGDRCRFLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BB65</accession>
    <name>A0A2S5BB65_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY73971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BB65"/>
    <dbReference type="STRING" id="741276.A0A2S5BB65"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY73971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="216" mass="24562" checksum="E3F201ABA783696B" modified="2018-07-18" version="1">MNRLFGSSSAKPKPSLTDAIASTDLRIDSIEVKIRKLDAELTKYRDQMRKMRDGPGKSAVQQRALRVLKQKKLYEGQISQLQQQTFNMEQASLTTENLRNTMATVDAMKTANKEMKKQYGKIDIDKIEQMQYDMEDLIEQANEVQESMSRSYGVPDELDEADLEAELDALGDDFAEEEQGIPSYLREDATSELPDFVDEPQMQQEAPKERLGEGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBB8</accession>
    <name>A0A2S5BBB8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_2832</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBB8"/>
    <dbReference type="STRING" id="741276.A0A2S5BBB8"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="25"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY74021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="349" mass="37286" checksum="009CFA69C9319249" modified="2018-07-18" version="1">MSSPLKFLAMGNPLLDMSVSDAPELLEKYGLKPNDAVLAEGKQKEIYADLQENHKVLYVAGGAAQNCARAAQYVLPENSTAYLGAVGSDSLAEQLRAANDREGVYSAYQVVEDKPTGACAVILNGHNRSLCTELGAAESFSPAHLDKTEIKELIERAESYYLGGFFLTHGLESALKLAKTAAENNKPFAMNLSAPFIPQFFKSQVDEIMPYVDVLIQNESEAEAYAASHEWDTKDIPTIATKLAELPKKNTATPRLVVITQGESSTIVACSTPSAVGLSESPKTYAVQKLESAQIVDTNGAGDAFAGGFLGARALGKSVDEAIEVGHRMGAMCVGCNGPTFRFPKENVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBE8</accession>
    <name>A0A2S5BBE8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_2902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBE8"/>
    <dbReference type="OrthoDB" id="2535424at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="573" mass="63418" checksum="F789C1ED11C6F637" modified="2018-07-18" version="1">MLEHCMSGNVTFGAGVPDGAAWIGPNFAALLEQIKSGQSPYLFLIEIVHKLYHPAVPDGFHVQLYVQLGLFSICALLILLGLAVRLLQGRFWIFHRLDRTIVLPNASTLFGLCALVFVGLGFWLVISTIEISQGADLPRYYTGLRVAWFGAIWTGAFFEIWTTVAGWYVRQYGTHYRESRRRSCVALLIPVAVFVIAWVPPLALCVPHARRYNRSFRISQEITNDLWRWQRTWRSGDGLDMGKLLSLFTPGAELGNELIGSHRLSRICSWFCTGILFITFIVYVLAASLEISQLGKTIRDLQGQAAQRMAQVHELPAIPSKPAPPASLAASDLPELAYCHNPTPASLEPYKSSERKAETQRRPRHPKDGSLASWALLAWVRRNRIYSAGCIAVMLLAQAAVDLWRAVAPLNIQYPSSRFQVEILVSCWIHGVLATTVSLLLLFRSFDASSSRLLRRLERACTWLPFPPSVSSSAQKSITSEDQPPIYHAQAPSGDTIPLTPYPAALDSPASVDKHPYAASSLPLESIPSFPSVGATVDCGEANSRLDDDPSTMYLRAVAQAQARWLPSRSANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBS7</accession>
    <name>A0A2S5BBS7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBS7"/>
    <dbReference type="STRING" id="741276.A0A2S5BBS7"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="112" mass="12298" checksum="1AB86619947AAB17" modified="2018-07-18" version="1">MGWFSSSETSSSRSTATASASTSSGAPDRSQRAECWTSRDAYFGCLDKNSVQAPGQEGSGVCQSENDEYKRKCAASWVDYFNKRRVLALRQDLMERRAAEQVQELAGGKATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBW8</accession>
    <name>A0A2S5BBW8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBW8"/>
    <dbReference type="STRING" id="741276.A0A2S5BBW8"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box protein Hrt3/FBXO9 C-terminal" evidence="4">
        <location>
            <begin position="457"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="3">
        <location>
            <begin position="801"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1194" mass="134274" checksum="8AF66D4AC6A1230F" modified="2018-07-18" version="1">MSSPPQEPAPDLEDELAAFRAQWRQEAERKRQQPFVSDSASTSSRPDDTQHRQRPDQAAELPQSPDRPTRRSIDAVQDELAAQVEAIDLETSPRADRRDAALVPKQRDREREREREAAQERARPKSALELYEFAVSSEREGRMQDALVNYRSAFRLDPDVDRAYHRASVAAQKQTRAAEPRQTGSSIQPAAQPDSHEFRFERTVQLGPDYDAKQEHRTKEEAQRESGRADADSTHPSSTAFLLRSLLKSIAENPWVRPPPTVRSSTSEVHAADQGGENGHVPKAAKATPTAVNAVADGTVTPSASSEEALASLHFIPADEEKPLPLARLPFEVLLLVLRHLVLSSMLPPPRSANSLEDASHGPLAQSAGATPAISAPRSKRQPRKRTLREEMLMLELELELENVDRDWRSDVEALERFACVCRAARIVTLDSGLWRALCLRTYVPPQQISREEDAKQLVKAHGNDWRRFYIEHPRIRLDGTYISVVTYLRRGEVSSIYAPTHLVTFYRYLRFYHHGLVLSLLTTDPPGTVVRRFNPTLRMAGLSFGRWRLRGDRIQLWGLQDPSVPENRLKYSFRMSLDLKSTARGRMNKLVMISLATENKQTLEVEEVPIRPTKPFFFSKVAARPAVPTVTPHASDVTPRAGSFAPSVENGDAGPSLSLLSYLEAHFGPPASSPYHVWITLADSTWASTGTAALHTFVERLNVDRRAAYGSRRGGIKDTKLVVLALDEQAIDIVGRYTDANGLVDKGGYAYGGYLFNKPEQSSPSIERDPTHAAPLRTAVTRRGRNSQVSFIEVIPHRDLFFVDSDVFFRHDPYPHMESYMEGSYDLIGSENHAWSHINTGWLWMRKSQAIADTWHEVLRQNMQSRSRDQIRFNEILNTEPRRQWGDGRDQLAEPARSDFVGRSGIRVHVLDDNLFRAHHFDFGRPFAGRDRSVYLHMTCGDDTPTKIYMAKAQGFWPDLDGYYTSPQRTITIDRLSGSREVVTQIMKVLLTAAHYTNRAFLPPSHITFLSHLPSSHASRAIYNAFPIPHLASGLGVRILEPDYPQNAAAVLARRDTLGPSQRREPSASHASRKLAKDSGVSAISAEQAKAIVRLGDVAELDMRQVPDLTTFLRLLRSDSFATASSIRLIKLDEPTPADQYWRHWQLPSILDKVETCLELHKMPFCDAICRGSKEGHFTFPGEWPQVQLGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBX2</accession>
    <name>A0A2S5BBX2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBX2"/>
    <dbReference type="OrthoDB" id="3361009at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="107" mass="11653" checksum="DB465B9F81A705A3" modified="2018-07-18" version="1">MQQHQAMAAEGREGHFNEITQRWETPDERPEIAASQAASTMPDSDGHDASKGPSFTQQVNGFAKRFAGKLTGKEHEVAMGDALLDGKNVDQARATAEAVKMDQQAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC64</accession>
    <name>A0A2S5BC64_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nucleoporin NDC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BMF94_2554</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC64"/>
    <dbReference type="STRING" id="741276.A0A2S5BC64"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="396"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="POY74360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="74423" checksum="D759A09BB2AA9BF2" modified="2018-07-18" version="1">MSAFAPRSASQAGAPPTQSNLDILHSTFVANASPAPSQEYEKLCRIVLQRRLRNLFGLSALAASAALAIAIFDPKELPASLFNIVPLVLFTPIAFLGALPVLVLRKRTLTTVRPPLPTLFARFSSLRTRTSSVPVLIAYLLAVAFLHISYIWAASWASEDAQLGFFFFHQGRDAWQLNERRVVLSLLHVALALSATVQHVTQDRSQVVFDDESSATIPTRLASRGRPRLVAAFGSATKAWVASWSTYVLFRRPVLRFFLAHVLPVWTRTHLFSMMRYNGAMSLTLAARAFSSTLFIFLVIEATHVLFEVYATQPMVVSKFGSSPNQVLLSGLRSSDPYFQQFTFLELATLTLRDASRRQAIFKDVRPGSTTAGAWAEISRECLLLLGTELQRAKGRGRLPDTSSAFSPASVSSASAGQASDRPQGPNRAAIKSGDVFQPTRPSLFDKVAAAATSSSSASLGSSPAAQSATAALTTGVAAQRAQQAVSSALNVATSAISRVPAVLQSSALVPSAVSDAAVAARKAAEAAPPPANVADVAGVEHSIARFVPAFLRGGVFDVAIEYRVTNCVKRRHEVVCAIQALSNLVCASLTEDPYGVAQRDIPKILEAFVRFLSVVKSLRAELEDVAEQVSGGQEEKERARKLVQREVGEVEEALQAGAKAILTEFAEYLGEFRFPTQIAAQLQLLVDWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCP4</accession>
    <name>A0A2S5BCP4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCP4"/>
    <dbReference type="STRING" id="741276.A0A2S5BCP4"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="212"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="333" mass="36633" checksum="220B8776070E28E9" modified="2018-07-18" version="1">MATKRRASTPSQEQDWQLAGTTSAARTHVWPQARPAVKRKKTANKDDQVEPEPEKRLRVYKKACPKATLERADRVFAQRFFCVDRKRTSPTAEHFSVLGSTGNLYTVKIQNLPSCDCPDGAKGNHCKHLLFVFLKVLGVPTHSNLWYQSALLTSELEAIFALARPAPCNVLEDRVKTAFEIATGKKKVDTSTDAGGGDGLVKKRIPQEGDSCPICYEDFEAGKKTGLIFCLSISGCGNALHRECFQNWAKTSKPTTCPLCRETWSSTSAAADSSSANALAGPSFSADGYQNFAAQAGLSTVRDTTSYYHGPRRGESYRSGGGRRKRYEDDGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCQ0</accession>
    <name>A0A2S5BCQ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCQ0"/>
    <dbReference type="STRING" id="741276.A0A2S5BCQ0"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="447" mass="48857" checksum="2C53F067D93CCACE" modified="2018-07-18" version="1">MAKLLRKRYGFLPPDGQVDHLIIGAGAVGLAIAERLVRAFPNRSTFVVERRGQVGQETSSRNSEVIHSGIYYPTDSLKTALCIRGRDLLYERCREQGIGFRQTGKLIVATDEGQVPYLRKLYKRSETLKQGGDSPVPLEWLTGEQIRALEPDIGDQVVGGLLSPKTGIVSSHEYMESMEKSITDSEAGEMVLGTRVVRIDRAEPSGGGKRGDGSEDGWIVQTVTEDGSGGEGMRASVLAKSVINAAGLNAHHVLNQVLPESEQLRLYFAKGSYFSYRGPGVQNVQRLIYPCPEENHSLSGLGTHLTMSLSNEIRFGPDVEWLDPPRTEDGEDMPDFWESKLAVSEERLELAVNEVKKFLPSVDASGFSPDYSGIRPKLTPRGGTSVDFSLTLPRPGFISLQGIESPGLTSSLAIAERVEEMVRKQVWGLGRGTGKTISEAGRLEAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCW8</accession>
    <name>A0A2S5BCW8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_2386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000023">
        <property type="protein sequence ID" value="POY74625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCW8"/>
    <dbReference type="STRING" id="741276.A0A2S5BCW8"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY74625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="194" mass="20016" checksum="BCDD03D5261E4F67" modified="2018-07-18" version="1">MSANQAPPKQPTQRKLTKKGLFAKDLAPMMYGFGDETPAPDSIALMEELVIDHITDICVQAHRVSTNRGKIKVDDFRFALRNDPKKLARLDELLFMQEEIARARRGFDNSFNDYANDEDLAAARADVAAGITTLGGPSSAANGPQNGGGSGATGFGKKPTLSANASAAGGLALPGGGSSSKGKGKAAAAASAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDF3</accession>
    <name>A0A2S5BDF3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">BMF94_2056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDF3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDF3"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="107" mass="11805" checksum="90F70CA247B8D680" modified="2018-07-18" version="1">MTCRCVRLACIVRAWIRSPLAEQVLVITQDGRVIVGKLMGFDQTTNVILADSVERIFSPDEPVIEEPLGVEIVRGDNITLIGAVDEEADKEIDLSTIRAYPLADVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDH3</accession>
    <name>A0A2S5BDH3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_2092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000021">
        <property type="protein sequence ID" value="POY74819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDH3"/>
    <dbReference type="STRING" id="741276.A0A2S5BDH3"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY74819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="497" mass="52103" checksum="D4E76A5C7E513367" modified="2018-07-18" version="1">MLLPPPIPGSVALHQLLVDPSTSFHTRNLTDANAARGTVRTALKHTTKNANSGQADWTGAARALQEYLGHLVAILACVEADDLVLRTDPVFFQWRGSLSSSPLRKGSQRVALPSLHAELTGTLLAYALCLANQASSLVASLGSYEISASVSSAAIGVHDETINSAADTLCRASGVLMHLAETVVPRWEAAVGTEALRQRPVEMTREVTTALAKMCLADANLLAIRRLLSRSLSVAHSTTTPGPPLPPGHPSPSLLAKLHLHVYTLYDEARTLVKTVSSSTASGPRSNLTGAASSSGEIVLPLRRYLSDGRTLALALSYKWLGVDAGERASPPATGDALGYLALAAQELDALGDKDKGLKKLKGFGKGREAGKGRKGKVQEERESTEAFRSAYEKVNDTVHFQPIPPAPTLQSRLPSGRAALAPKAFSLPPPAFRPSLGTGARPPPPHKIPPPLPPPVGLDGMGGGAGGDDSSDDDDDEAGADDATQVGDYFGAGQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDS9</accession>
    <name>A0A2S5BDS9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDS9"/>
    <dbReference type="OrthoDB" id="10690399at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="851" mass="88020" checksum="52C18D3D01C922E6" modified="2018-07-18" version="1">MTPPRSNGSRDTRAARNLASVPPSSPTSSDLLLPTEVVTSVKQAAKPSAESGRTDPPERIAASKPTSRNGVAWTAEEDARLYAAVVEHRQENSDRFPADIWQFAPGDDPTWIAIRTRFVTAGETITRTDRTQYALRGRWKTIRLRELATRASETASSSRLDASQNATSSVATAIEADRSSDSEMLGAPNTTEQNEPRASASSSGSAAQAVDGDAQQHALAEADQSLFDVDSTEAEQQDEIFSSLLSAEGMAAMSAPDTPASSTSSAQDDSLSCGIASSTPNSQPSSVAGSSHGLTYGAIATTSLAEIPLSLDMSSAPTQATLVGADEADPSLAGTTPIDLREATRLPDGLPPFVVASFGRKDPKDKYRGPPPVVPDRSDVLTGASARVPAQDSITVVNPASKSGPPSSGLTSNNGLTSYAAGVTATSAELDASPSQGRQSQTTATANPSPRKLWTAEHDAKVVEMRERGCTQSVIAAALGRTPTAVKNRFQKLRLDGILPPVQPKPAASGSATAPNSPRPVGASLPSATRQQSETPATLPALTPAAGTPLVSANESAPLPTPAVPASRPSVAPTPITPDAELPLPALPAAAALVATPLGPSSTSATALDVPAAATLPAPLPPYTPEDDAVVLRMYLQGASAERIASTLHRSIKSVQRRWVKKKGEWMAQGLIQSTCQLRAREPAASSATALPARPSPPTSIEATTTAEAFANLRGTASPSPTSSILLAATAATGRSSDGPDGALADDLGGFDGSWYADGNNCGVGTSVTRLNTDPTAAGSSSPTRAALSSLAARQEDSQMTNGAEESLAPEDSEQDRDETAGRLIPESDSFMAKYETGMRGLSRFMQLMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDT4</accession>
    <name>A0A2S5BDT4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY74935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDT4"/>
    <dbReference type="OrthoDB" id="2535883at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY74935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="679" mass="74141" checksum="02E2FB773E8A02E3" modified="2018-07-18" version="1">MELHRRTLSSSSSSAGVPLLDPRPLPRDRADPRSNMAATRRIQVPSLRAGAIRARVVVQAAILLSLAAAAGFLLFGSSAPQRGAQRQTEAPFAVQDLAPDPPKRVVPPAKPRPKPPRPPLLPLEDAHTGGGAASSGEDSVSDAALHLSPTRRTKDVSYAEPWVLKGPRHKLPKCERILVFTFMPWWGFASEYILYTRAAAAAKKLGYTFVEDDRNWNYGRLSNYFQPRKLDCIPPDDWPDTRLALPLSPKTIRTRPSRLYYSRLNLSKLDDWTRETYLSSAVTVEQLANLRGTDREHAAMRDRAILEEGGTLPAPFERIFTDQSSAARGMWKPNAEVRNAIEAIKRQAGMKEEPWYAGTSSDDGAGLAGGAADGQGRGPTIAVHVRLGDKSSEYEHDAAQMGITNTFGNLSVYLQGAHDAYRRLIPSRYPALDPKAQRYSPYAPPTLLLVTAEPDISTQLSADPLLAPFRLVQTPDPDVQSANVDKSTKDRLAADAKKGGKSGPKAYADNDASREDRKIVKRDEAPSLMTGYSQAAFNALPMLERVVHTQAFVRDLTLLAKEADAAIVSGASNIGRLAMMLAGRDAVIGPRTELGHSLGGKMWVLSTPSYGLSERSVDAHWYPTAYADAVYHKIEDVEDLDNAAFLPEEQHAAEKAAQAAKAKAAKRRERQKAKKGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BDZ8</accession>
    <name>A0A2S5BDZ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BDZ8"/>
    <dbReference type="STRING" id="741276.A0A2S5BDZ8"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="8">
        <location>
            <begin position="809"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="992" mass="108612" checksum="01141737CEE0DC3D" modified="2018-07-18" version="1">MHGSPSLARPPFRTRVTRVLALFAVTLLWLGPATTHAAFYGSQKKTELRARARETWYHAYDSYKKYAYPADELLPLSCKGQGHDRQNPDNAAVNDVMGDYVLTVVDSLDTFPMLEDKEGFEQAVRDAIEHVSFDVDSRVQVFEVTIRMLGGLLSGHLLATPPDSGNFSSSIRGYSLPWYRGELLDLAHDLGRRLLPAFETPTGMPFARINLRHGLRGKGGKAESGETCSAGAGSLLLEFITLSRLTGDPIFEEVARRAFFAVWHRKSDIGLIGNTINVRTGLWLHGVAGIGAGIDSFYEYAAKAYILTGEDDYLRVWEEGYAALQRYVRTQDGFWFRGVNMMTGQLSATTVDSLSAFMPGVLTLMGDLDTATKLHAPFAFLWSRFSGLPELYETHRRTGAHYGFPLRPEFIESNMYLFQATQDDWYLEVAERALEDINRRTRVECGFAAMLNLGTGKLEDKMPSFVTAETLKYLYLTFVEDSPFLRDDGAFVFSTEGHPLEIPRRPSPPSPSRRTKLARAFSSIDARNVTEVAASGLARSCPAHEPVFDERYSHFLSLGMDRRTDWEHARWLAGYAPPDDSEWLASGRWSPHGWCQVAESEKLPVGSQRLFDPVANIRSLLHNYLRTALLPSAFASRPANYGIELLFAAAGGEEIVSPEPSQVSPHPSGNGDVVIHSVTGLRLLLTPMPYGSDGYFISRIGPVNVPSGAHVVIRDQAVVSTVPAIQPVTKIRLEARSNSIATEDSLASSAEVEPDESRYPAQLDIPALAASFGPSIVYRPPEALPPGAKPFMLDGPPLPLRLPRFDILGCEPPSPSPAEGTEREPHLLLLHRGHCSFALKSHHAALAGANGVIVVSHPTPTDDEEGHNLGGFVVPGAEATEESDETMEALVPLVLVANSTGQALEGLVRRAEGLAVDGGLVDVVVQRTAEAQLVLEGETGASNSSVMVRLVAEPDPTEPEEEEEHVDGLILGGYLVRNIKLHRIRNASPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE54</accession>
    <name>A0A2S5BE54_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE54"/>
    <dbReference type="STRING" id="741276.A0A2S5BE54"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="116"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="265" mass="28454" checksum="2D55DE88E6A2C261" modified="2018-07-18" version="1">MSSSHHAYEIAPDDEDLELQDDLVATSRNGLLPTHTTPASANAKGKGRETPAGPTLEGRIGGTSAGGAGGGSSQRQTAFGGIQTETRYTGTDTLDEPVSETIMRDLRAIGNKIVQVLHPSSDNAVLRDWDLWGPLIFCLTLAILLSTNAPADQSLPIFTGVFVIVWLGSVVVTLNAKLLGGKVSFFQSLCVLGYCIFPIDIAALVSVFVDLLWVRLPVCAITLAWSVWAAVNFFGGTRLEKDRAVLAVFPLFLLFFLLAWMTMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE61</accession>
    <name>A0A2S5BE61_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_2017</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE61"/>
    <dbReference type="STRING" id="741276.A0A2S5BE61"/>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="63"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="516"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY75041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="548" mass="60967" checksum="ED1662B6F3AB491A" modified="2018-07-18" version="1">MLRLATPAFNATPAIWMNAARSVHRSAVTSGLVARQQLASSSLYPAGRIAGLHSTRLVHLDTERQTSAVQHPPPPAESGSPLTKRRDASASRTSSSSSPSTPSNLFQHTDSSRPPPPDPLAPPSPDARVPKRRITSVNELPKSFGRNQMIQIPERIQHDLEDVMSTFKAPIRYAFAYGSGVFQQKGYTNEDKPLLDFVFAVSHPSHWHAINMQQNPEHYSYTMRLLGSNAVAWMQEKGLGAEVWFNVDVEINGKSLKYGVISVDALCRDLLDWETLYISGRTQKPVRILHDDARVRLANQVNLASALRTALLLLPEEFTEIELFEEIAGLSYRGDFRMRVGENPHKVRNIVAAQLPAFRSLYGGLLKSFWKSVHTIGEDFTPTAAYPFVEEIGGVRLMRQNLAASVRGHTASRLPIGLRNKVLGHYERKWNLEGALLRERDQKLHDNEREGLPLDLESTKMWERIVEDAEFKQVMDKSLSQIVARPTFNQSLKGILSAGPLKSLRYVGPKLRKKWLASTTSSSPAPPPKPISPPAALAADKAAPEKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BE78</accession>
    <name>A0A2S5BE78_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_2029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="PJQD01000020">
        <property type="protein sequence ID" value="POY75053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BE78"/>
    <dbReference type="STRING" id="741276.A0A2S5BE78"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY75053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="363" mass="40642" checksum="62D9EAD8B9A0040A" modified="2018-07-18" version="1">MVNPRVFHDYAVVGEQVTPLGRVVFELFADKVPKTAENFRALCTGSAGVNSIGIPLWYKGSPLHRVIAGFMVQGGDFTDRNGKGGESIYGPSFEDENLTREIDSEGLLCMANKGKNTNSSQFFVTLRPCPHLKGKHVVFGRVVKGFETIVAISKMSVDAKDRPLELITIQHCGELERKVVAKPPPPPPSSSSSSGSSRSRSLSPDRSRSKRSRSRSHSHRHRSRHSDDDDGSDFGAEERDHRRRHRSSSEKKKHRGSTGHRSSKHGKSAASSSRKDRDRSPSGSPELTEEQIAELEKRAREEAEEARKRREEEEREAVEKAKRAKEERERYEREQIARGGIIYKGSGRMKAGREEGRSGMRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEQ7</accession>
    <name>A0A2S5BEQ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEQ7"/>
    <dbReference type="STRING" id="741276.A0A2S5BEQ7"/>
    <dbReference type="OrthoDB" id="2339190at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015503602" evidence="1">
        <location>
            <begin position="18"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="298" mass="29454" checksum="E7BC49A46871DAC0" modified="2018-07-18" version="1">MLSNAALLGALVSFASALPLAPLDDVSAGLALTRRAYSTTAPPAQLIDYFPRFTSPATGDVYQAGGNIQISWNATKPNYPDSQLHTSAVVILGYLDPEDPSSGYNLDMQHPLGNVSFYSGSGSVSLPLPANLTTRSTYLLTMGSTRNISPLFTIQGSAASEASSSSSSSVAAPTASAAATTSSSAQIQSLSAKPLTVYFPDGSTTVLGGATAAAAAVTPTSSGTSLNDIAAPSSAQSSRAASSSSVAQQATPSLAQAGAAASPSASTAKSGAGSVALTSRQSALGLLVGAALAVGMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BEX7</accession>
    <name>A0A2S5BEX7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BBC1/AIM3 cysteine proteinase-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000018">
        <property type="protein sequence ID" value="POY75324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BEX7"/>
    <dbReference type="STRING" id="741276.A0A2S5BEX7"/>
    <dbReference type="OrthoDB" id="3357271at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="2">
        <location>
            <begin position="132"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="357" mass="38837" checksum="B634BD0D7AF2E72A" modified="2018-07-18" version="1">MPPQRPSASRSYPPTETHSSAALSLLHWLLDPPDLSLELGNDPRSDPPFFLPPPTSQSPMPPVLVGRSDVRSSFSWMQRGEEKTYGASFLFGDGSIAWIRLSWHASSERRGTVTRDVKREGRYRPRPDIARDRDGDRLYAASETYGPRIVRFARDAVRGGRPIARGECWDLANEALKACEDEMPPGGRRPMPSIARTHGALIYYASAGRSSGGSGDRVMGEWTGGDPYVRPGDIVEWRSVTIREVGMGLGSYSTLGDPEHTALIVSAGSPLAPPALPGSAPYLDSAYPLSSLVSLTVVEQSPGSAPAEKTYDLAAMSAGEVWIYRPCALKDLCGIDELAPRWPDEIGVQSWQTGELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF47</accession>
    <name>A0A2S5BF47_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000016">
        <property type="protein sequence ID" value="POY75392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF47"/>
    <dbReference type="STRING" id="741276.A0A2S5BF47"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="78328" checksum="328916D29930BA9B" modified="2018-07-18" version="1">MDCLKAVQAYVDKAITQTRGIKVLLLDADTTPIVSLATTQSHLLSHEVYLTDRIDNPARHALPPATSQSSSTQGAAYPPASGGQRGVERLPHLKCVCLLRPTDESIEACERELKQGRFGGYWLYFTNVLSKSRIERLAEADEHELVKEVQEFFCDYSPLTSSHFSLSIVPTPLHPVPNQRVMPLYGDSPATFSSHAPVLDRHLEGLTALLLSLKKRPIVRYERMSPMARRLGQDLVAQMNSDEPGMADLWEFRRTATAPLLLILDRRNDPVTPLLTQWTYQAMVHELLGITNGRVSMEEVPDVRDELKEIVLSPEQDPFFANNLYDNFGDLGAHLSAYVQDYSTRSATSQASKIETVADMKRFIDEYPEFRKLGSNVSKHVALVGELSRLVNVRHLLQVSELEQSLASNESHGTDLRAVREAISAPEIPQEAKLRLAVLYALRYQKMPGNQIDGIVDLLRQQAVPDAEMVHVMLNFAGADQRQDDLFGNENFFSKGKSALKGLKGVENVYTQHTPHLAETIDLLLKGRLKESSYPYIDGQNVSPQGMSRPQDVIIFIVGGTTYEEAKTVAQLNAQFAAGHGLAGSIGPAGPVSANTRIILGGTCVHNSKSFLTMVRDATFAFGSSFSAPLPSLSSSSTAPSASFATTTGPTSPTRANAFTNPAAAVAQNFNLNLGPVSLNVGGQAGNAIEAGVDAARDGLRDVFGKLRSRVENGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BF78</accession>
    <name>A0A2S5BF78_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Abasic site processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_1491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000015">
        <property type="protein sequence ID" value="POY75421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BF78"/>
    <dbReference type="STRING" id="741276.A0A2S5BF78"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY75421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="50111" checksum="ECBBBDF62AC64E57" modified="2018-07-18" version="1">MCGRFALGAHAEQLAADIHQQYFVRPPPPRQQQPPAGAGGAAGGSSHAGSSGAPSSQTRPRAQDESASQDDHPVQWASLETQDSFRPRYNVAPTTKVPVLRRSKKDPNAYELDLLKWGLVPHWYSDPPAPGLSTINATCESVFQGTPAWRGPRQDKRCVVLAQGFYEWLDKGKEKQPYFVKRKDGKLMAFAGLWDHCDFKGNLDPVTSFTILTVPVNEQLKFLHTRMPAILDTPSEVQTWLSAAPWSDELKALIRPYEGELETYAVDRGVGKVQNDSEEFVKPLAEKKGSLDSLFAKQAASTSKAAPGSKSAFKSPNKSAKKEDAEAMNPDEDDDEEKLQRIEAGIKGEQEAKPDVKSSRKKKAAPTATSPSASGGKRKRSSPSAVADKGKKGGKNDVEVIELDDSDGSDAEVIDVKPPPGKRKKVKAGSPSSRPNDKPESKHSDGEGNEVLTDFFSVEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFE1</accession>
    <name>A0A2S5BFE1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFE1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFE1"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="179"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="522" mass="57100" checksum="16CDB9541A4EBF65" modified="2018-07-18" version="1">MSPARPRLQSPSFWPVEVQELVRFALYDSLAQDFVASSCNRFFEPSHCNDGDSGAPPRTRVRRGQGGSWAVLPAEWQRYFEAITDANEREETLVELSRGGQALTGAPASLLDYLGHCRTLALDRTCSDDPILSFPSRQEGLPRPRPFVQGEKSYRERTAVEAEAKINIKNALKAGKSPKKEHEVDRFGTLVAGIKAEGPLTHCVDVGSGRAHLSRALACSPLDLHVLAIDWSASQKSGAERLDTILTDARLAPTIGSLTHEVCSLDASGVASTLGRWPPGGPTQATPPSLLVALHACGDLTPDAIKAFISVAQPGAKAVFVGCCYNLQTPSLFPLSTFFRELLPTNGEEPMNRSHLRLTPQAPPTWHLSPASTAAWRASTLKLAYRARFEAELVAASPQIGPPETHRIGRVAECKSWETYRERAVRKLDDGTLGTVLPELEVEGGVEGWETALFLLRVFWTVRSWLGPPLESLCVLDRFALLCEGLEGEWDGEAKSTRRRVELVNLFEQATGSLRNLALVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFF1</accession>
    <name>A0A2S5BFF1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase 64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_1396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFF1"/>
    <dbReference type="STRING" id="741276.A0A2S5BFF1"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF2">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase 64" evidence="5">
        <location>
            <begin position="49"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY75494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="429" mass="48334" checksum="CEF2F4FE56E09A8B" modified="2018-07-18" version="1">MPPRRRTRAFVGVVFAVCALWGSTLLWRRSEAVEEKRTVVLTAYETQGLRPAWLRQIVEQYASDDYADLIDAILLVWNAPEEEPPSDLPAKVQVIRAAANSLNNRWLLTPEYAQPGPVIVLDNDLLLSKSGIRCLQAVQRDHPDRLIGPYVRRREDAIYVLDELMSRSSPYNFVLPRALIGHTELLDLYRNPELAQLHAYVDEQEAHCDDLLLNLAVSNTTGVAPLRVALPPSSVRDFATYCSPLDRAQSAGLADQTDRWKYRTECLQHLLSQAGFSTESSPEDEDVALCSQDGESYDLVSEVGLPRWRSMSTARAIDLCPELVPERDLAAESRLGLGRELVEYCPELDPGTTEWIDALIDKPLCGDGGAIQDPHLLASAKHQCGAWCMWDLRVRGKTGWRLTGSCFERFEGGHPECDKWFYQRPHMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFK5</accession>
    <name>A0A2S5BFK5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_1443</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000014">
        <property type="protein sequence ID" value="POY75540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFK5"/>
    <dbReference type="STRING" id="741276.A0A2S5BFK5"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="251"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY75540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="409" mass="41325" checksum="06193B86987CC85B" modified="2018-07-18" version="1">MADPLGSDKLLERARSLAGSTTSLSSALQALALVAHAIHSQLDFRLVSPTELSDDWLNKDSFKLKYRHDQSSLEFVVSIQDLNNRLLVAAAADADDANSRSSTLDVAVRDYFSPSAFPCPVGEVSDSKPFAASHRFKDLVVLYRLNIVQKLLPGLSKQGYSEVTSTEASRASGAVPSSSTAGQTPTAGRGPYLPDAGGPMGMYPRGPGGNSGAGGRGGDPSPATPLPGPSPDDPLRIPGSGGRGGGPIADIGRRDLDPLGGMGGTFGGPSGFGRLPGMGGGNGGFGGLGGDNGGGMYMGPDHPLFRERFGPGADVAGRGNAGGRRWGGDGYLPPMGAPPGARFDPVGPSNGPPGGGVGGPHNSQIGIGSGTGSPQGGEPGGLGRGGPRVHPDMEQPGRGNSDWHDSMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFT8</accession>
    <name>A0A2S5BFT8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFT8"/>
    <dbReference type="OrthoDB" id="2527131at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="252" mass="28119" checksum="DC4438762598E07F" modified="2018-07-18" version="1">MKRPSRTGGSRAAAKSSAAKPAANETRVSLMDLIWMLQPVPVGTPHSLPALGSPKPWYILPAVLSPMPAPWDRAPNKETLRLEQTHQEAAKAAKAFQRAQEEAKPPRDPAAIKAEQNRKKKERKLRAKARKDAEANGEAGERDDAKDGEDATESAGDAKATEADDEAPVPTVAYALPSYLDDEMQEDFLKHYARMHADMEERRRDEAVVTLPEQFQRAPMGDVFLYPREHLDDPQRGVTWDKDSMSLLYHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BFU6</accession>
    <name>A0A2S5BFU6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_1266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000013">
        <property type="protein sequence ID" value="POY75644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BFU6"/>
    <dbReference type="STRING" id="741276.A0A2S5BFU6"/>
    <dbReference type="OrthoDB" id="2529777at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY75644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="475" mass="52307" checksum="0BE4BB0235C15FEA" modified="2018-07-18" version="1">MATSGAGSSHGVIAAAPPNHYTSQQQQQQQQHRTGPDRILIPISQVGHRKSTLSDSSSIASESSTSSSASSSEFLPTFRSVQRSHFFQFCATVLLLFVVPLAVLVSFKREFRSDAFALGFGAWLASETLGQVVFDLLTPAKHEAAPTTLAAEYENLVLDDDPRDMGRRPPMRDDEPPPRPSAMPTIVYSIAQEALRLGVVAIVVRLLPTEAPVAPSRIALLLASADEPDPYPQPHPHPHLPPLDPLFWSALWLALGWAGAEILWGSRRLWHQLELYKDVLPLYEGAGGEREVLLGVPSAREDGRAGGAGYGAMDARDGEEALGPADVGRWRSRYEEHADQYDDSRGDVIDEEVMSDEEDFQYRVREVQREELEDQLGVPLFEVPVGIIFIWRLDSLLLALVFTLFLALPFRLTPPSLFQFPLWPTFAVVCLTHALLSYAWVARVRKIGIPSISYASLIVLVALTFAALGSWGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGV2</accession>
    <name>A0A2S5BGV2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_1069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000009">
        <property type="protein sequence ID" value="POY75984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGV2"/>
    <dbReference type="OrthoDB" id="2537639at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY75984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="655" mass="71966" checksum="26E18787359EDB9E" modified="2018-07-18" version="1">MSLRTLLNEPMVPMRLDYPAEARPGSSLREVPGVEQQHRPSRPPATHHDSLAAWQPAEARLSPRSDPSLSASLAHSAESMTVAQVLHTTSLLKVERVVNRMRTALAAIPDSQSLCKESARAITNAFNAAEPADARAALWQTWQRYTAVAQRLAMPLYPVQPDQVALAVSVYTPLPIRSVLRDFAGVRDTIPLAGVREMMSGLNLAARATRHLWPDIVCFIRAPDHYESTKAVLHFIENYAAGRSFASRQPAPSDFYSAAVARQARPPLPPSRDSAPRPLLTQVPPAAPAPQTMTPPPDQFIQPTRKPPKSLREICNGLPALLRELADQPHDPADFDSAQERFSAVNTPQYAGRAERLFKTAVEYTKVSALLEFPTYPITSLKLVVFALTMTPGPLGRTLDSAAPQVPKDRPLPRQISTEFEATMKDVTTVFQITRGEDQEPQKAELAQWKRWWEELTADWKQATKKREQSQPSQPTQPARKRAKLSPSPTASEASVASTSKAAPAKVKPAAARSRVSVTEPPSRSASPSQNSTRASSVKPAKGKGKAGKSRPPTPSPIVYPVFVPKQKGVLPADRREPPLPPIMDSPWYVPKKKKEKAKVEEGDEQGDNDDGLSEYESSEDEEAAKKRVGRSVALHRPRRGANDMIAFDVSTLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BGY0</accession>
    <name>A0A2S5BGY0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000008">
        <property type="protein sequence ID" value="POY76036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BGY0"/>
    <dbReference type="STRING" id="741276.A0A2S5BGY0"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="73"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="310" mass="33342" checksum="D1B5C8D0B91F05AF" modified="2018-07-18" version="1">MASKRPVTSPEDWSKRLAEVNVSKDDLNFLVANYLFTEGYLSAAEHFTREAGLDAITSSTNSSSKAPSFDVESIKTRMEVRRAVLKGEVETALDKVVDLDLEILDLDPSLHFHLLQQHLIELIRAQHIPEALAFAQNELAPLAEEHPRFLKELEKTMALLAFELPTLSVLPSVGDGAAASTTTAPAAAAAAPTTMMLPSVAQSASVKEKKSKKGASSAAAADPALPPMPTAILSLLDPSQRLRTAWELNAAILNAQGHASEPKLPGLMSIMNWGEGLLNEKGVDWPRWNLHDLLSEKAVESAAAADAMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHL9</accession>
    <name>A0A2S5BHL9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_0474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHL9"/>
    <dbReference type="STRING" id="741276.A0A2S5BHL9"/>
    <dbReference type="OrthoDB" id="2520612at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY76279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="410" mass="44914" checksum="A3C78958D68A0818" modified="2018-07-18" version="1">MTLGHQHPDVPARFKAAVFPAPGAPLEIIEVDYKKPGPHKLAVKVEACVLSDLDAVSELGLLRPYAKYPRTPGTAFVGTIVETGSGAREGGGTGGLTGGPISQLVRRISRFSLGRSADGDKDKTEEEVEDKHTWKVGERVIVASTHQGCAEYASAHADAACPIPTDMPVFESMVTATFGAKILAAHQVHEHHCHNMLEDDVRLLVARNEREGFAEGKGAVCVYGQGGFASLAYHSLRAEVHKDNRLLLVSTSETHSHVDYNAPREDFMHGNLGSGLLDKFRPHGGIKHLICVEMPRRENGFEYLLDAMRHGGQITLLNIERDMVLQIPPAQIVARSLVIRGAPDLHSADMVHALKQCHRHDLHRHVSIRKHHFTEQGVREAYARVKDVQDSWDAQVVCMSEVETVQVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHQ5</accession>
    <name>A0A2S5BHQ5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHQ5"/>
    <dbReference type="STRING" id="741276.A0A2S5BHQ5"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="360"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="636" mass="69873" checksum="0591499341152FA1" modified="2018-07-18" version="1">MYRGQPSSFRRSGFLGTFFLQTRSWPRTRCERRREGSDTRPSLARHTIRLGAHCYPSYRLSSMTSKQTPPAIRKASRPATRKWTVLAFAAPLVYAFCSSERVLGLLPQPVQSLVQDVTSSLDFSSLGVEIPRCPAQPDARNVGPDWMPAEDPAYKARAIDRLSGAIQIPTETFDDYGTPFTDARFDKFAAFHVYLETAFPRVFRVLRVEKPQKYGLLITYAGTRGRAALGAAALKPVVLMAHQDVVPVDPDSIGDWEQPPFSGKVDAAGWLWGRGAIDCKNTLIGILAAFEQLLEEGFVPERDIVLSSSFDEEIGGTRGAIYIARTLEERYGRDGVALIVDEGFGGIVDVFGRRFAMFAVAEKGAVSLRLEVNSPGGHSSVPPKHTSIGILAKMISALEDHADRPALRLGSPKVGELQCYAEHGEMGALFKRSIQTPILWPSVAKKLAKLDKLSEASLHTTQAVDLIHGGVKLNALPESASASINYRIEYTSSVSATIEHASAIVEPIAKRFGLVFDKLGSHSHVTQSVARLSIVDHSAYEPAPITKTEGPTWDLIAGTAKHIWPGAIAGPTGMMANTDTKHSWNLTSNIYRFVPATIHQVKGFHTINEAVHVDAHLSSIRFFYKLIRNTEGWPMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BHY3</accession>
    <name>A0A2S5BHY3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_0583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BHY3"/>
    <dbReference type="STRING" id="741276.A0A2S5BHY3"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="145"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="305"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="440"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="560"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY76386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="671" mass="73880" checksum="816CA22782DAE4EA" modified="2018-07-18" version="1">MPFDSVKVDKHSRAATLEATESQIDLDSTGRLPKSTVMTALSTNAKSDAPAGKWTYDQVRETLKTVSIDSSGQVELDDFVDLVDKLRSGAGAQAGKVHRGGALSGLMGAGSGAAAVQAQNTGDKSSGGKVLVKGSNTNITHSINEDERTEFTRHINQVLAGDADIGDRLPIPTDTFQIFDECKDGLLLAKLINDSVPDTIDERVLNKASRAKAPSAMPSAKSKATLNNFQMTENNNLVITSAKSLGLSTVNIGASDLNEGREHLILGLIWQIIRRGLLAKIDIKLHPELYRLLEDDETLEQFLRLPPDQILLRWFNFHLKAANWHRRQVIFGAPDVPTFLLMGYDVADGENYTVLLNQLKPNECSRAPLQENDLHQRAEKVLQNADAIGCRKYLTASSLVAGNAKLNLAFVANLFNTWPGLEPLEENERPVIEEFDAEGEREARVFTLWLNSLDVEPGVNDLFEDVKDGLVLLQAFDKMIPGSVTWRRVSKTPVPLSRFKAVENTNYAIDLAKQNNMHIVGIQGADIVDGARTLTLGLVWQMMRRNILSTMASLSKNGRDITDSDIVKWANEQVKQGGKQSTMRSFKDPSLKNAKFFLDLLESLKPGYVDYSLVYDGRNDDECKANAKLAISIARKLGSLIFIVPEDIVEVRPRLVLTFCAALMALQTASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI41</accession>
    <name>A0A2S5BI41_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI41"/>
    <dbReference type="OrthoDB" id="2526341at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="112"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="215" mass="23131" checksum="1981F8DBE412B6C3" modified="2018-07-18" version="1">MGSRTQYRRKATAVVSYAPPSESDDSVEEPCAGSCTTFSNKPQKGTREAPPDEQVDSSDAAAESSGDDFRPGQALKKKTKKKRRPHKKAKHAAKAVTAAGPAVEQDGCDGKLEGIKLVPMEVFLDILSKSSPGELLSLSQVSQGYRSIVTGDNSEALWRQARANYQLPDITSGGFTELHYAGLFFGKGCAACDSNGGAPDFYLRVKLCRTCRHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI47</accession>
    <name>A0A2S5BI47_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rrp15p-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI47"/>
    <dbReference type="STRING" id="741276.A0A2S5BI47"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="32903" checksum="38A1E1A56052C0FB" modified="2018-07-18" version="1">MSAAPKSILKKRPRAAVEPEAEESPVVPGQAISDERVHPVDGTAEDEEDDEDDDESDEEGVADEDEFSVGSDDSGDDDGDESDEDAIRDMLEEGQERPAKKLKHTTLRPTSASAFSSSLQHLISLPSTASNPVPKNAGPSAATLRLERKTRGVIRETKAAHLARGHVRDVIGGWGPRPPLPFSEWESKAARNFEQAKRGGKLVDEGETSAEREKRLRKLAQRGVVRLFNAIGAAQGVSGKDKDIEEQEKRKKLAVKVTAKDGGEGDSQGKTLSRRPNILGARGKNDALTSLSKASFLDLIRAGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BI93</accession>
    <name>A0A2S5BI93_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_0675</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BI93"/>
    <dbReference type="STRING" id="741276.A0A2S5BI93"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY76474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="307" mass="33842" checksum="22DA640A73943E15" modified="2018-07-18" version="1">MSGTVVQRLLYPLHLAVLASLHAALATTRATRLALRLLNLFLAPFQRQTDPCCPAEDLATRRWAKIPRHLAVSLVATPSGSILERLEARRHVDVLQSLLSWSRQLGIATLSVYDETGALLRHATGHAEALDLRVISSEEETKTEGIVTLVESWSPMKSEVRQSSPDGTPTPRSAQEDASADSGTTLVADEAPPAPLRVNLVSRAAGRPRLARLAQDLAVQSHQTGAEVKSERVSEVADSLPLGEPDLLLVLGGSYLRLHGFPPWQLRLTEMYHHSWPTWFSKPPELTYNILRRALDVYGRAEMRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIB2</accession>
    <name>A0A2S5BIB2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000005">
        <property type="protein sequence ID" value="POY76495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIB2"/>
    <dbReference type="OrthoDB" id="2425321at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="896" mass="96666" checksum="97546F16C79EC625" modified="2018-07-18" version="1">MPLSSYDPRASSFARAEEVLSRKLTLAIDRGGASAPLGVRLDSEHVSQPFASSRFVTAYELIVPTATGIDRYPARQPLGRLCSSARSYLAALPPATLRRSFGPTNHSPEDLDDTRVMMAEDCSDGDLSISSTSLTAPAVDANHTLSSAGATPISVASAEKHAEWPPVRRHRSASSSTLSLDTRRPPVTSRHRHTQSTSSTHAPIPSPVYLARSQPIGLLSRSSSRRSLSEEQEKTAPIPRRAPLHRSESLLTFPPEQPRVPMERSREESVSMDELAALPVDPKDWRPSQLSLYLAATLALPPPLRADITSFVVSSCLTGRTFLHLREGDLEELGINILWRKALLEARDRSKRESNGGRTYWALEGPPLTALDLVSARQTSSSRRLSDAGSVASEAGEAVKEEWKTSWRRRPAKGSTSKVDSLRQTFERGKTDATSRNEHDGDEATGRTRTSSIGQIASHGSITAIWPFASVGGASHNVSAGLSPVLSAADTSIPADGSADDDFEPPSSFSASPDSLTTWTPLPFLTGAGLKSCAATFARDEDAFVSSARSRHSPDTLRTRSPFDSWLRPNAALHPSRARPAAAKAGVTDEDELDTIRPVKSPEPHIPASDGHASPVPAQDPSALAQLFNLELPRSPPTGPISDMPRGGHARPDGSEDELVPMLVPPADDVRHERDMFDGGSSVRRKKGSLVLVRKSQFVALQSRMREVEAQFSAVLVASPSLDEPVSVDDPGGTWQFKGEEISSEELLQLDAQMRRLEAASSQIPLGSGGPSLADRDAAPPTDGVPSRSGSLMAPAVPSAEETSRPVTFARRRTRRHRRTTHELSQFENPDDDTPSYMEETDAEGGDVWDVGRSGWPHDRIRGWKQLSGYVVAASIGIGIVAGEVVASKLLGLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BID6</accession>
    <name>A0A2S5BID6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000004">
        <property type="protein sequence ID" value="POY76514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BID6"/>
    <dbReference type="STRING" id="741276.A0A2S5BID6"/>
    <dbReference type="OrthoDB" id="2529719at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="618" mass="63433" checksum="AA6FF321B2DA8CAD" modified="2018-07-18" version="1">MADSTTLDSVYPNSGKPASVDPDANATVFSHSANGTSSTWVAHPSTQGRAKEHRFSATETQAKEVEVVLIWDDDKQSWSIEPLDSHYNLKLDRTPVRAGKGGPPPTPAVPTEDELHARAASFFTSAAPNPFATFAYNPPALSGGADGPSQPRATTPPRPVSAGSLASLLNPLSAASPSHAATFSASPQGAGRSAGPAAVPVSVSVSADVEDFGEIRAAAATAAPRPRKRTASPAATPTATTAAPLPRASPPHAARLSRSPATTAAPLQLPKLPTAYSPPRPPHHSPPLQPRSSPPHPSFSSKIPASSTSAAAAAAAARRRAQEEQLSRELEQRLNASDSASSDEDSADEWQPVAIEAEEEEDDHLGTSNKRKKIAALASSKRGAAGAPTRPRQIRNATAVASASLGPIEPTTMTTTTTRRAPPPAVSATASGPVPPRSKAADLAKAGAAAIQRVAPNIDSDSEDSDSDDDGDSSGSSDGGGTGGAAKVKRPSGRKGARGQAGTQPPSRGVPSLISQQVNAQMARIRSSSSMGTATPPPAVAASASSEYPRIRTAAAVQQQQQQQYARAASVGQPPRGGTPTSPQVRQSRPSAPPPRNSDEARQLAERQADIPDSSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIL9</accession>
    <name>A0A2S5BIL9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_0211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIL9"/>
    <dbReference type="STRING" id="741276.A0A2S5BIL9"/>
    <dbReference type="OrthoDB" id="3360715at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY76621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="381" mass="40885" checksum="31B19FBC134FE665" modified="2018-07-18" version="1">MQTAHTAARLTEVQVIEGFHALLRNGLAEARRDGFLTDDDIARADIEVQIAGPALVLFYAALQAENDPPSIASPDGTFRLSIQTCPPSFADAFRLWQQSVPKIQSYEPELRRDLALILCDQPPQSTPLRMDVVKTAADVKGIALEILQRRTFQTRFETDLQAVLAPGQTDDLAVPPASIAYQPPPAYVPGSVDSDPVGQRTATVGGGGEVAYVSAEEEEAHLSLMSRGSEFAAKAFFAATCLAILEVALTRATPEGIRPVVLNQASPRVIGVRETPAHLRPFLSRLVEVSQAVRTLAEEDDATAVREATEGAETLSHPKLDLLRARLENGMGPTASASDADVEISQLANGINGLAFGMTSLPAFRDRQAQVFPILLSVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIX2</accession>
    <name>A0A2S5BIX2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIX2"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="147" mass="15747" checksum="17B823D7320CE9B4" modified="2018-07-18" version="1">MLKAKAKAAATAAAQKRKEYWADSPATILAPGGSIQRIGYDQSTYEEAVRTIIFGEPMPEERKAAVGLIPPKEGSDAAAEKTESKDEPAAPEGYKTNKEDLAIILDEFDNVTSAQASQTLRRHKGDLAEALVELCAPRVSPPPAIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BIZ7</accession>
    <name>A0A2S5BIZ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_0343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000002">
        <property type="protein sequence ID" value="POY76751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BIZ7"/>
    <dbReference type="STRING" id="741276.A0A2S5BIZ7"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY76751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="251" mass="28967" checksum="486C998FE6847144" modified="2018-07-18" version="1">MTDYAEERRSELEVLESIFPDELEVISDDQLAIQVEPDVQSEREPYTVRLLVTYTDTYPDEPPELELDMVEGDVLDDELQFMLDGLKETADESIGMAMVFTLASRLKELIAEMIVKRKVRIAREDDERFRREEEALAARKKGTPVTKESFAAWAAKFEKEFAQIQKREEDDRLKALPPKEREETRRWVAKLTGRQLFEQGAITVESDAAFGEEGDVALDISQYERRAAEDEDEDEHGVTERLRLADLSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ25</accession>
    <name>A0A2S5BJ25_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ25"/>
    <dbReference type="OrthoDB" id="2431049at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="3">
        <location>
            <begin position="303"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="403" mass="43222" checksum="9E2B436BD039712A" modified="2018-07-18" version="1">MAAAALTANKENRAPGSGVGQGKAALKAARKTTTTKGAKSRPNDDDDDDELMMGSDDERDQHSPADETTVVAETQFGEPAAAGSKKGSKGTAAPAAAKRRPAAASKKAAATTDEFDVAEQEQTNAKGSSAREKKLEAQLALVPAEKTVATYKAAADAITAEHAMLQETAFASPRSKAARLESARVQELEKENSALAARVEELERLRAEEQTAAETRERDLVERHRVELSRKVKAATASAEVELVELREEVKTARAELSAEVAQSKLLQQKLKSAPTAPTMAASSASAAGNDQARQLELDGITAKLNLNEDLTGLSVHSYRQEAEGSTYSCVLVDYAGETGGLNFKLTFHDKGSVSYNPDLDSARDPQLCELLPVHFQSYMRFEADKCAEWFKLLFAAVNRVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ68</accession>
    <name>A0A2S5BJ68_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_0067</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ68"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ68"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="111"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="254"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY76815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="411" mass="43170" checksum="6C8B0D12B580F9FE" modified="2018-07-18" version="1">MAHLARAAGRAFLRSTAASSSPAGPSSSSAALRSFSTSPALAKPPTSPTYTDADGKQRRRLIVVEKSGQAQFKTYLPVTPSLRQLRRPVSEHLHKGGPYRPLTIAKRGTGGRNDLGRVTTRARGGGHRRRIRNVDFVRRETGEQEVVRIEYDPGRSAHIALLKHKASGAISYIIAPGTLRAGDTVQSFRSGIPDSFLIGGGSASAATTEQLDPTDPSAPQSVTPPTAGGAAAGSSSSSPSLAQIDISTLRSLALRPGNCLPIRLIPVGTVVHGISLSPDGPAVLERAAGGNARIISASSPTGKHAQVRLSSGEVRLVHLDCVASIGTVSNADHQHTNYGKAGRMRWLGFRPQTRGVAMNPRDHPHGGGRGKSKGGNHPVSFSNVGAKGQRTRAPSSKNGNKMVVKERKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJ99</accession>
    <name>A0A2S5BJ99_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_0105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJ99"/>
    <dbReference type="STRING" id="741276.A0A2S5BJ99"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="535"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY76853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="905" mass="100223" checksum="0AEF238D87D0ECCA" modified="2018-07-18" version="1">MAVRRPVMRAPRVKAPRKQAEPVDATLDKLKEAIQQIQNHNVSQLSFEEHYRYAYNLVLHKKGHLLYNAVAELISSHLESETRDKIVPTFPQSVNAIASASAGQAGTSAAASENIAAAAAGQLFLDRVRDVWEDHIACMSKLRDVLKYLDKVWTNPAHNVPSVFDLGLSLFFHHVILFSTAPKPAAATSSSSSRANAPIAPSQRPTADPSSVARHLITTLLNVIRIEREGESVSRSAIDSTVKILSRLTDEGPVPLPVQASSGVGSGTPVVSASAANARARTVMGEGPPGAKESAYRTAFEQAFLRQTEEFYKIESARLLIECDCPSFLKRINRRLEEESTRAQSYLGASTEPLLISLLDNVLIEQHLTSILDHPASGLSTLIHESRIDDLKLMYTLFGRVGKGHSTLQKGIAAWIVQIGKQVNEGVSLAAPPVETDAGADGSSSAAKGKERAAAGAGEDDEVPAGGPARRTATSGAAPGGPINAKTKAALAWVQDVLDLKDKFDTLLDKAFADDKAFEKSINDAFSVFVNENRKSPEFISLFIDENLRKNLKGKSEAEVDEVLNKSVAVFRFLTEKDAFERYYNQHLSKRLLNQKSVSDDAERNMLSKFRIEAGSQFTKAAEGMMKDVKVSDDTVQEYKRYQERSSAKAPFEMVPVICGSNVWPFPSKDKPCTLPKILQDGIRSFETFYNQKHSGRKLTFMPDQGSVEVKTRFKARSHELNVSTYAMVVLALFEGLGEEENLSYRDIANSTNMVAAELKRTLQTLACAKYKVLTKHPRGRDISESDQFSFNFGFTAPLAKIRIQTIAAKVETDAERRETESKVDEARNTQCDPTLDRFRTACVVRIMKDRKQLQHIDLVNEVVRQLSHRFQPSPQMVKKSIERLIEKEYLERDDADRKKLKYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJE2</accession>
    <name>A0A2S5BJE2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BMF94_0137</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJE2"/>
    <dbReference type="STRING" id="741276.A0A2S5BJE2"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="18">
        <location>
            <begin position="57"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="565"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="POY76885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="642" mass="70454" checksum="E6E942F6B50800DE" modified="2018-07-18" version="1">MTAAARSEAAADVPDPSTVEYDSPPTLDQLEPQPQANHAKLEGHQFWDAIGKPKYIVAPMVDQSELAWRILSRAYGANLCYTPMFHAASFASSAKHRHEMFDLSPDSIEGVAPYDRPLVVQFCANDKDHFLNAAQQVTDRCDAVDLNLGCPQGIAKRGHYGAFLMEEWNLVRNLISHLHQNLTIPIIAKIRVFPSLAKTLHYASHVYSSGAQLVTVHGRTREAKGPQTGLASWDKIRRVVDLISPKVPVLANGGIPSAEQVEPCLEETGAYGVMSAEGNLYNPMLFAPSNAAAGRAYVDQLPEPMRSEFKACEQELDLTGAGWDRDRAAYAPSTFIAQQYLVVVRTLPSTKTATSAIKAHLYKLFRPVWAAGRHQEMREKLGKAGGISGTMEYLERVREFQQWLDEFRQLIQADREAGLLPPDSNRPLTHAEVQSLFDGVIPYSHCQPYLRVTQPSETKEELELKMVDDAAKRKREVDELGGIDPEAEAKRCKPSPPSPSAPIAGEAVPAPSTFPCTTPSCTNAAAAKCGNRVCKTCCAALRAPDSTLTETAVAPSTHVCEFHETKEAREREQAQRRKEQQKMKRERGKQKAVENNARVKALSEQKRQEREAQAAAALQASATTNAAQGTEDGAPTAPEVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BJE7</accession>
    <name>A0A2S5BJE7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_0133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000001">
        <property type="protein sequence ID" value="POY76881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BJE7"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY76881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26667" checksum="3E636F4A595D8F79" modified="2018-07-18" version="1">MPDSRKIYFITGANKPNGIGFRLVEKLVARPDTLVFATARNPTRATELQALADKQDNLVLLQLEATSEEDARAAAEAVKQKAGKIDVVIANSGYFEAGNVLEQSIEGLRKSWEINALGPMILFRALAPLLFKSSAPVFVPTSTVAGSFGLDLGMPLAAYGSSKAALNFLTLTLHHAHAKENLTAFVTHPGMVDTDMADEALPALGMTKEQAKPISVEESTEGLLAVFDQATRGSHGGKFFSYDGSELPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZE0</accession>
    <name>A0A2S5AZE0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_7089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000169">
        <property type="protein sequence ID" value="POY69909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZE0"/>
    <dbReference type="STRING" id="741276.A0A2S5AZE0"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY69909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="428" mass="45402" checksum="3648C58289D034EC" modified="2018-07-18" version="1">MAARSGIEPSEETLQAWQDQLNDQEIRLVKWSVDGEKVVPAGAWPAVARSSPADDTADAFEADFGLFNQEGIAEDKTPAYFALRRVCPCTSSGPAGRGADDHDCRLSPPPSSTFAFIAYVPDHAPVRPKMLYASSTNTLVRALGDSRFPVRMSAAEKGDLTYKSYLSTVTHDSAAAPLTAREAEMAEIRAAEASTADDADSAQARAGRSIIFGHAEGEQGGEAGETSEITGALPWADEVKEKVRQLGTDAEIGSCAVLASLLRLIARLSHADSMDWLSVQEIDIAKETIVLAADQPSSLAAPTSSPCYLLYRHAAGLVLIYSCPASSPIKSRLVYSSALLVFYKRALPQWTGQTVIKKLETSDPSEITPDWIDTELGPLAATASTDATVAGGADESSTPASGSASGTSTPKPESEVKFARPARPGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5AZM8</accession>
    <name>A0A2S5AZM8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_7037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000156">
        <property type="protein sequence ID" value="POY69993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5AZM8"/>
    <dbReference type="STRING" id="741276.A0A2S5AZM8"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY69993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="450" mass="48348" checksum="04E1F3879509EE2F" modified="2018-07-18" version="1">MESSSRPNSAPGSPNLNLQGILKRHPADAFQRDRIASPVDGDFSTLNLGGPVAAVPTFAADGSSITTGTRTPALSIDTGTSSEVTTLTGGETGSSSTRARRHSGNFQRRVGFNTFNSGVALEGRPTVTGGGTGESVRAGVAYSFTLSAKSAEYKRSRWSRTFLVATDLNEYSVNATDWLLDYFLEDCDEVVVLRVIEPSSSAQTAGFETIMRDARQEAEGVLDYLMKKNGDERQISLIVEFAIGPIEETIHRMIEIYKPDSLIVGTRGRPDSLFKSAFMGSISRWAVARSPVPVVVVRPDDKVREGLERRLGDSKRGRSYVALLTEEERKRLLPPSETSISSLLSPLSPAVTRQLPPAPTSKTGANGAPLERIVTAPEASERSSVRGGDESDSEDEDAQRRRVQFAEAKKWSNAAGGGSSSTGGGLMAALGFGKKKKDKGKQFKKFGTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B003</accession>
    <name>A0A2S5B003_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6887</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000145">
        <property type="protein sequence ID" value="POY70113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B003"/>
    <dbReference type="STRING" id="741276.A0A2S5B003"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000595">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_5G11840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="386"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="613"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="674"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="885" mass="94506" checksum="4DB55FFA1A685A2D" modified="2018-07-18" version="1">MATAAGPTLGAPASKPADVTQTTPAAATVAPHLTDSPANSPALTTALANVGALQLGAAQPQSSGPSPAPSINASSTQTSLGVASEANGGASRASSTTEFTPSSSENPSLASSWRESAADSSVYTASGTATPSDASTYSGHESGSVSDTPGKTMPTALQNSHHIRRVPSHHLSLDEPNTGTPDLGPADHTELRAAADRLRGQAAQRQQPQRHTLYHNNERDSSLSAQPSRAVNHHHNSLASGSTTPGGTATPPQFIFAKIGERKRAASHSNLSTMSRQSTKTHHSGPLHDLRRFLNDHLHSGKSSSHSPSHGGSKFELGAPHDSHGSTPRSGKSSPRHSSQPGTPQGARTPVERDYTDTASHPEYHGHGRHSPPLGENHAHLQKKYGKWGKMLGSGAGGTVRLIKRQRDHTVYAVKEFRAKRAGESEREYVKKVTAEFCVGSTLHHPNIIETVDIISDHGHYYEVMQYAEFDLFSIVMSGKMTRPEIYCVFRQIVDGVDYLHSMGLAHRDLKLDNCVMMHDNTVKLIDFGTAVVFRYPDQKPTKASGIVGSDPYLAPEVIGKKEYDPRLTDVWSVAIIFMCMILRRFPWKLPDSKTDASYRLYVSSHPELCRPPTDPGALIAGKPLPARPTMPQDSLSRRTSRSGSSSPFVNGDVAPAAGTEQDVSAMQLSALERYDSPSRMSNYDGSESPSLSSRGDTLAGSVGSLRISEDAESGMSTTRRQSTRGSVSTAVETPGGDLGVAPRTSTSTTRPRTADSGPPPAPSTGAAQGLAMTPAKEGRGRSDSVASNATWTTGAADSIFRLLPRETRSCLTRMLTVDPSIRCSLADLLRGGEGDDIDAARTDEWLPNIKPCIYNRGAMSANRDDQHDHIKIPADNSKMPKMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B084</accession>
    <name>A0A2S5B084_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000150">
        <property type="protein sequence ID" value="POY70071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B084"/>
    <dbReference type="STRING" id="741276.A0A2S5B084"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="359" mass="40013" checksum="F67304A9246A1477" modified="2018-07-18" version="1">MVLHSETSHTFPIPFPYIVLAHNQRYPSPYGRHILSSDVISRSFHPDTNVLRTTRLVLKRGKVPRWAPQMIQKIDTTWVLEESEIEMGLVEPDGKTPLRNPAGDAASLASSEAIPASASSISTAANEAAPESGVKRELRTRSRNIDRTEFMEVFEWQVFRPLPEDTLATEVNTLSRVTSEFGFWPVSHRIEAFGLSKLPRSIEGARLGLQLVADLILRPSTSAAFLSSGPLEPYQFDPVPSAFSLRIRARLDEARTKWTEVEHGLTAEEAEQREIDRSEVAESRRRGWRVAGDRAASPEDMAGGEPVGLTAWRERWRSSYRRGKSRFRERVCAMTGLLCDAKDPAAVAGVDATSRPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0A4</accession>
    <name>A0A2S5B0A4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_6906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000146">
        <property type="protein sequence ID" value="POY70091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0A4"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY70091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="50" mass="5790" checksum="668483C6B9CA9171" modified="2018-07-18" version="1">MSHDDDEAQPMWGRRVGSYRIKVSRRIHQTDIATSVQPAARKPVRRSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0C0</accession>
    <name>A0A2S5B0C0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_6799</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="PJQD01000140">
        <property type="protein sequence ID" value="POY70216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0C0"/>
    <dbReference type="STRING" id="741276.A0A2S5B0C0"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="280"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="591"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="864"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY70216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="894" mass="97777" checksum="C311BCC500537122" modified="2018-07-18" version="1">MPLNAHAAARLRAKKRSRSSTAAQDSSSTASAEIPRKLATSSTTSQPKAKRLRTAAPKDLGWKSITLPAELGFDDDGGLLELDEVEGVDVVYEDGRIAFKVRDDEGVAQPSSNSTKKGKGKATERDDDDEEEWQPVTDGPVEEEGDEPAFDDNEVLEFPPEEDADEPSTPSVPATTATPPSLDGPPEPEPAAKQEKKKKAKAKKDAAKAGKQVATEAVALPPTKPFDAASELPAWAHLHIANPLYRALAESGFSKPTEIQDRALKLNSPANAEEPHVSAFAAPHAERDVVGIAQTGSGKTLAYGLPILSHILSQAPTPTPRAASPSGSDFSDASDELPPTRLAALILCPTRELALQVRQALSTVAVRTLPLLPSSPETDKLAPEDPRRRQKGRLVQVVALTGGMSVDKQKRQLEKGVDIIVATPGRLWDLIGEASTHSDLLVREIKGIKFLVIDEADRMIENGHFAELDNIVRLTRRTPEQAANGYVDDFDASITSRSNVNQLPARPDMRTFVFSATMSKELQTNLKRKGGQRKFVPRAVEGDITSLDDLLDKLDFRDPDPEIIDLSPEHGLVETLKECKVECLQNEKDIHLYHFLVRYPARTIVFLASIDGIRRLHPLLELLKVNVIPLHSGMQQRQRLKALDKFKSSTDGVLLATDVAARGLDIPAVSHVVHYQLPRSADTYVHRSGRTARAGTAGLALQLVAPEEKKVQRMIMASLGRADDLPSLPADFSILDQLKRRIELAKQVDQAHHKLQKQTHDDKWLRETALAMEVDLDDDTYDSDGDAPRASSKKERSKLAYQNRALRQQLDDLLRKPLMVRGISAKYLTTRNKVGLVDQLVGGTSHNKIFGLDQSSALEDLARAPREKKKAQKKLADQRAADKVGSEAESDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0S8</accession>
    <name>A0A2S5B0S8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000122">
        <property type="protein sequence ID" value="POY70390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0S8"/>
    <dbReference type="OrthoDB" id="2525644at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015403759" evidence="3">
        <location>
            <begin position="17"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="580" mass="64748" checksum="A6C3BA50B6652BDB" modified="2018-07-18" version="1">MLRFAVLALVATPALALRQPWEYLEAVERFQQEFLDPQRVVKRGRSEVLADDIVGRVDVTTTFEGQELNTEYLFGLFANIRDEHNTSILGFPSHQTIQTLVVEPPVVYFSAILQIGYPTIKEQEIPVQVDVITAWNDDLKMISYDATFRRFPLWMDEVARKIGPTLAKELAFEYDPDRPDRLFAHKAATDICPTAMTHCVGHNQQYTSYDECYDFLTVQRPWGGAMEGGLDTTLCRYIHRNMVPIRPDVHCAHIGPSGGDMCIDRDYVEVATAFPFKQTLVAVNTTWDDRDMGGLSPESVKALARAKLTIALPTTVAFFSVPTFACFLSLYILAKATERTLAKRSAAFNLLSQTNRRNLVTYVLATVVTTLALGFQLVALPSLQHEYTPAGIRGSTVASTLVTILCERCPFRTEQNIRLTLRSPDLFELIYRDSMRSSLLIHHLCTLLAISSLYISLEHTFHPATLTVGACKLFFAVYLLLEHTRSLSRFTDSLYDIYFSVIVYTIGTLLLTTQVWGSWAVWAIAQKLVVSPITLPHTQPSRIDEASPLISATVTLVGSVDGSDAEDGDSGFKKPAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B0V0</accession>
    <name>A0A2S5B0V0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_6578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000118">
        <property type="protein sequence ID" value="POY70403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B0V0"/>
    <dbReference type="STRING" id="741276.A0A2S5B0V0"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY70403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="306" mass="34843" checksum="D30FE547535EF693" modified="2018-07-18" version="1">MASSLDRQIEQLRNCQPISEQQVKDLCLKAREILVEEANIQWIDSPVTICGDIHGQFFDLLELFRVGGQCPDTNYLFLGDYVDRGFYSVETFLLLLALKVRYPDRMTLIRGNHESRQITQVYGFYDECMKKYGSASVWRYCCEVFDYMSLGAVVDGRVFCVHGGLSPNVNSLDQIRLIDRKQEVPHDGAMCDLLWSDPDDIEGWGLSPRGAGYLFGADVVKQFVHANDLDLIARAHQLVMEGHKLMFDEKIVTVWSAPNYCYRCGNVASILELDENLQSNYKTFDAAAQQDSRNIPAKSTSLQYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B131</accession>
    <name>A0A2S5B131_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_6534</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000116">
        <property type="protein sequence ID" value="POY70466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B131"/>
    <dbReference type="STRING" id="741276.A0A2S5B131"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000011">
        <property type="entry name" value="small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY70466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="79" mass="8955" checksum="4C2609F87A5AE55B" modified="2018-07-18" version="1">MSLQVVNPKPFLADLTGKPVYVRLKWGMEYKGYLVSTDNYMNLQMANTEEYQDGQSVGTLGEVFIRCNNVLHVRAAPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B1R6</accession>
    <name>A0A2S5B1R6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BMF94_6294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000098">
        <property type="protein sequence ID" value="POY70710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B1R6"/>
    <dbReference type="STRING" id="741276.A0A2S5B1R6"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="POY70710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="561" mass="61449" checksum="F83D67C79A1EABA2" modified="2018-07-18" version="1">MIRRLQSPYTDPLDYANLGRAVPALAPHLSYSASGYAMLNFKNEQAVRSLNIALLERDFDLHVTFPEDRLCPSVPGRLDYVIFCLELVRQTRVDDAKTAESARMMGLDIGTGASAIYPLLATRFTARSEQECLGPVCMLATDVNAVSLAHARRLVDRNGLSDEIQLFQVDQGGQIFPSDVTEAAETIDFTMCNPPFYSSPEEIASSSAAKELPPFAVCTAAENELITPGGEVAFVGRMIEESVSLGQRKIRWFTSLLGKYSSIAPLVQQLKDKKLYNFHISALPRRGRTVRWVLCWSLQEWRVPPYLVHETLAAEHGAPTPASVPSFPLVRFLSPSVAPLAFIAPTFEPLGGSSVAQELIEMLTTALNELVQPGEIEPALEGSIATEEDGMASDCSVVSRAHRPIAVHITAWRNVWSRQARRAAKAAAPPDPAVLRAAESAAANRPETPMFDVRIEIAASAKGTPRSETSAKAGATTSVMNQPPASDRARPTATYRLEGWWIRGAEAERAALVGLWGFLTRRIGDECWRRTGLGEKHAKEMGRRAQGDDNEEGRGKRRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B292</accession>
    <name>A0A2S5B292_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_6080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000096">
        <property type="protein sequence ID" value="POY70902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B292"/>
    <dbReference type="STRING" id="741276.A0A2S5B292"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY70902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="758" mass="84664" checksum="A23995650C99CB26" modified="2018-07-18" version="1">MEKVQLALERLLPELRDLEQRQIFSHDEISDIVAKRRSFELSLAQGRGTKPTDYLRYIEYERRLEKLRKARAARIPKTAKKSLSDHSISAHITQLHRLSVRRFPESLELWDAFIAHSLSQASPLLVSRTLTAAIAMHPTETRFWIMASQWESDGDHKGMGGGNTEGARRLCMRALRFLKGRNNNERDLEAVWREWIRVEVAFVERLRERWQVLGIGKGKNGGEEIVRVDKGKAAGSEDDDDEADEAVFGADEIALPGEEAEESQLKEEVDQKALSGQEALLDGAIVRVVLDNLVKSYSHSVASYNLVLSILRPLASPLRLPLLAHAYASLRSNILPSTPNYPAAVHILATRHLYDVAYVPPKKNSKKRKADEMTPAPGSGTSEDPFAIRVEGERLVDAVGKACAEYWTVLKKTGTAAVGKKGKGKEREVGPQEQLLWEQFSGWLEEMADHADEDSEELREVDVLTSPFLQLAYLSANLEATLASAPSSAFLALVKLRNLLRTEASPTDVRSYLQRMIKQYGNDRTPPSQREQVWVARLETASTELEATPTPEEGTSLEGAFVQATRILPYSAKVWDLYADFVERQSDRTPGETEAWYEKSIRRSLLTDALPPADFLSTFSAYVHVTPRELLPRRFVHYLSTVSPSDFQPKVLRLLSSAPTLSLSFLSSILDPTGPALATASSAKGRAFRRQLHERIVAHPEAGADEWLAYAEELVRSGEVTKGQEVVQRARGQLSTRGEAAVRQFDAGWAHVCSAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2E9</accession>
    <name>A0A2S5B2E9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_6024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000093">
        <property type="protein sequence ID" value="POY70962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2E9"/>
    <dbReference type="OrthoDB" id="2528602at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY70962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="197" mass="20498" checksum="E38B42037A7D46BB" modified="2018-07-18" version="1">MLQIKTIQDARRTRAPLTVAAPSRLHPASVAGSRASPTSGMYARQAGLPGSGRALGGGRGHRHGAGAQWLGRQAVPTTFKCRAVAVQAAPSSPVTATAEEMPSSRDACNAPSESTTSILTEDPAVQANGPRETSAGLRAAAAADEPIRPRLETRQLSDDFELVPADGALEPPKASPHVLPDLEDWELVSPEDADLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B2X4</accession>
    <name>A0A2S5B2X4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000086">
        <property type="protein sequence ID" value="POY71120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B2X4"/>
    <dbReference type="OrthoDB" id="2530229at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="456" mass="48479" checksum="74E8C82DE997117F" modified="2018-07-18" version="1">MATASTSTAQYAGGAVPPTQLPVDPHTLTRYLRSRQLAALRGLYEYKTLAVTQQIAQHAASLRGRHGRARRRRGSSPLEERDLDAEDDEDDLEVRKRMRYDPVAEGQDGARANKARADGDESSTPAATASGTSTPVVPGTRASSQRAVVIPPTSSTRDRLPEDGAVDPAHVYDYVFDLAPDSSSDAYYHGAHPPPPARVVRTVLRATQKEPFFDPAGLSTAQLETLTTQLWDGEGKGLSIFFGDSGGSASQKRRGDQPLSRDQERYQREVNAEAADEWELAVIAGFSARCDEQIGTSLARKPMTAREMQAQAQAQAQAQAQAQAQAQAQLQARSALPHASQPGSLPPTTAAAPAPSQAPPATSLPHHHQAQTAHQHLAHSAPQQQQQQQQQQQQPHQPTSLAHMLPGYRGPSLGQPFGGGGASGGGGGGGGIATEYTKTDQRYGSAGPGSAAGWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B3J9</accession>
    <name>A0A2S5B3J9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylethanolamine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_5674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000085">
        <property type="protein sequence ID" value="POY71362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B3J9"/>
    <dbReference type="STRING" id="741276.A0A2S5B3J9"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY71362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19518" checksum="4763FA47903DB2F2" modified="2018-07-18" version="1">MASVTVDQIKQALSDAGLLGSTVIPSNFNPSVSVHATYPKFGNIQPGETYAIDQTQDEPTVSFNAPAGQEAKYTIVLADPDAPSREDPKWGPFRHWVLADVVPGQHPGQTLTGYMGPAPPEGTGPHRYVFLVYSQPVDRTPVLGVDGDDKRPSYDVQKFARDNELELIGANFFYAENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B415</accession>
    <name>A0A2S5B415_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_5440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000083">
        <property type="protein sequence ID" value="POY71519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B415"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY71519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="348" mass="37805" checksum="2550C210774C4359" modified="2018-07-18" version="1">MVAPNSVAENVFGTLGAVFWSVQLVPQIWKSWKRKDTAGLSTFMLFLWFLSGVWLGSYSVTSGLSIPLVIQPQLFCLFSAIAWAQCLHYDSGLGRRSATFLILGCLAVGGGVEAGLIFGTKALQHHGNERLNTATGVLAAILIIAGLLPQYWEVWKYKAVVGISLVFLTIDLLGGVWSLLSLVFSPPPFDPLAAVSYSSVVVLELGIFFLAAVLNPRYYRKERERKLKEEEEVTTVAAPPGENEPKGLLLQEEGESRAQLERKLGAGPLPLPDRLETDATMVEPPPAAAATGAPTHFIEAVSSREQVEREGGFGWMAHEDEDVEQAIGTGLRRIRSSRSGTSALRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B436</accession>
    <name>A0A2S5B436_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_5458</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000083">
        <property type="protein sequence ID" value="POY71537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B436"/>
    <dbReference type="STRING" id="741276.A0A2S5B436"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="391"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY71537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="613" mass="66744" checksum="F227B177EE6CC6B6" modified="2018-07-18" version="1">MPVVCTSSLLLKSIAQTAARMSFAADDASPVSSLPSSPSLSAGDDAATLSSTASSQDSLLEYRAPLNGEAPEPSIDGTSVMGGEGGIRAESADQVSDDDKQLALSLKSQANSQFTQSHYREALDLYTVSLNKNPFDPIVWSNRSAVRLKLEEHGLAIADASESLEAFLTARAIELDSRAVKAYYRRAIANLAILKPKAALVDLKHVLALEPNNATARTQLDATQKLIRRLAFEAAIAGKEEEPVSVSIRKQLAEGATPIPSDYTGPRLSGSDAAPEITPEFVDAMVQWFKDGQVVPRRTAWQILLGAYDVLKEEETLVDVPIPEGQTVDVIGDVHGQYYDFLHLLTLTGKPSPTHTLVFNGDLVDRGSWSTEILLTVLAYKWLYPKNVFVNRGNHETTDMNRVYGYEGEANKKYGGQAYKLSEEVFTALPLSTLISASASPRPDASPNPPNPTLHQNRKRFFVVHGGLFSKDGVTLADIRKIPRMSLKQPGQEGLMCEMLWTDPQDAEGRGPSKRGVGLGFGPDVTKRWTDLNEVTAVIRAHEVRQGGYSVEHDGRLITVFSAPNYVDQVGNLAAFARIDETGEIKYTTFEAQPHPTHIRPMMYAGGMGMMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4A6</accession>
    <name>A0A2S5B4A6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_5306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000075">
        <property type="protein sequence ID" value="POY71613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4A6"/>
    <dbReference type="STRING" id="741276.A0A2S5B4A6"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY71613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="283" mass="32166" checksum="C334837A3A0DC52F" modified="2018-07-18" version="1">MAHAHASHWFCEPCDQTFSTRAARRSHSNRSQRHIHDFCGWCDRFLEAGEDMNDHDEDYHYPCRACDEVCESLEDCNEHGRLYHFWCDTHERAFRSQSNYDQHMRSAAHVGLGHRCPARNCGRSFRDRATLLQHLESGTCPSGVNRRLIDDFIAKHDRHRIITTGPSRNLLVGAAPAVRYIATERSCDWTRSVHVCALCQSEHDSLQALNNHWSLPRHTYAGANGPDGRRPYKCPLSTCGRQSNTLSGVVQHAESRSCAVLQAPRVVQALDNVFGGMRLLPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4B2</accession>
    <name>A0A2S5B4B2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000076">
        <property type="protein sequence ID" value="POY71608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4B2"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="115" mass="12435" checksum="2EB0003B7FC54A83" modified="2018-07-18" version="1" fragment="single">GRDRTVDSKCRRSPFDTRHPRDPSPPRLVIVPSQQFLQPQKTCSRTAARVSMSSTSGPAAAINGTTAAAAQPTSSKVKSRGQLKRLKKKQKGQGTTQPDEDAVTLDRPLEKPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Q6</accession>
    <name>A0A2S5B4Q6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_5130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Q6"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Q6"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY71769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="298" mass="32893" checksum="2F948C88D1FCEAD4" modified="2018-07-18" version="1">MPQDLKTKEDYRTLVDRYDVFLFDCDGVIWEGDHVIGKAKETLQFLRKEGKRVFFVTNNATKSRKANKGKFDKMGIQCEEKEIFTSASASANYLKSVLKFPADKKVYVLGEKGIEDELDAVGIKYSGGTNPEDNVFIDLMDFSSITSDPEVGAVLCGLDMHMNYKKYARAFKYLRENEGCHFMATNLDSTFPTHGTVHPGGGATVAPLSCALGREPLVVGKPEAPMLESIVQTHGFDKSRMLMIGDRLNTDIAFGNKGSIDTLMVLTGIDQREGFEKEDAVATPTYVLEALGDISVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B4Q8</accession>
    <name>A0A2S5B4Q8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B4Q8"/>
    <dbReference type="STRING" id="741276.A0A2S5B4Q8"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="75"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY71758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="806" mass="85622" checksum="0FDDC3BFE2AA96F5" modified="2018-07-18" version="1">MHSHRKGGEQPPIASLASESVSLAAEAQVTPSPLADDSRSVQDALPASHLIEVQRALADHDVVALRALSSRPGGFLTSELRKRAWRRTLTSRPLLLRSNAKGKGREDDAATWDLCALPVRDDERQVRLDIDRSLVNFPHDVRDDDRDRLRVKLEHAILTVLRRHPALHYFQGYHDIVSVLLLTLEEDDLVTAAAEKLSLHVVRDSMGPGLEPTLGYLKIVHRLVKAIDSDLYQVVSQAASMPFFALSWALTLFSHDLDSVATLARLFDFLLSHNPSMICHLVVALLLFKKDDLLAVSGACDGDPAMVHSALSQLPHVHLGSGAVAPVDPVTPPAIERSSTRRSRTPSSSSSNSSPTRHRSGKLDSHREDLSEANDSEDLMSSASFMASSSDLARSPTLTASSSVSTFDLRDQTDDLDASVISASEIEIGDAYEHGGLRQRRRHASDSSKREASSSALATTFANGYDADVDLSRGIDDDDSLHTLDESMFGDPDIEGLAFEPFPTASSSARRIPVTPPSPDSRTSRSGHVVVSASEAPDSPGHLPPKRTVDVDELIARALELAERFPIVLPSATGGECLSDSVPAAEADASTVLGASSSRRDLSRAELADQVAANRILGPNSCVFTWRRSINGTLTDGDAEEIVRLGEGIVFPEALGPDLDDPVLADGADETSSDEVGDADSEEYDIVPSPGEERDDSTVAAKRRSGRGKKKRRSSSALGRLPPMLALGPHGWLVVSGVAVAAVAYGVYRQQGSVATAGAGTGLGTAGLGLGLGGFGGAPVIQDGARGAADSAVGVDGLAEGIRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B541</accession>
    <name>A0A2S5B541_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_5192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000072">
        <property type="protein sequence ID" value="POY71831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B541"/>
    <dbReference type="STRING" id="741276.A0A2S5B541"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY71831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="757" mass="81512" checksum="91887FF62262C426" modified="2018-07-18" version="1">MAAPDPTFLLQDLLSPPAEALQPRLLAQQVVLHLSTVPLERPHLALISLLARYTASSTALWDSSTLSRWDRCMLAYETFRQSTAYRLDAITRPPAESRARAGEDKARSGWTARKEVRTYLDEVCAGLWADMARTPGQASGFGAVDPLIRLAITSGILAALQDWKRRKERLWVGGSHALPRAERDVGRAWREYLQVSDAASDLEAAAWLAAQVVPSVAIERVAAEWPAPALLGCLSAALSRAFGDGYAFTDPPLAADLVIGPSGLAWSRESPSHTRITQLTSSPLFASLGSLSRAVGRVTEACALRARSADPGVAMAALPPIHSLSTSQLALASRLETGWAATPWADIVDENDLAPDTRVETAPWTLLKSLLFVQTMVYSSLLEVLAYSREGAGGPSTVQRTLATEAVRALSETYFIALRFGQAGFPAWRAVLAGLIDIVTAPSTSHSNPSAAAAAPSPAEELARSLEGPAGELRNGQHSHAIDRAKVTFWMNTVEQVAPALSDKYVEERVLPKCRPYLDDASYRDTFEAAHSVLLAIFMASKACANEVAPWYLTLVLRTYPSLLSVTQLRLAYSATVAAVSRTDDALAWWCIEELVDRIESLPVGAQATSQASDDAEKEDSPHVSPLDARALTLPRGAYLLSLSALLPAVSLPLLRPLLHQVERLVRQEPVENDGRAAIVEDVFQQVGTGMDAVKRKDATEWWLLHGADLRHAGPAERTVDTSPAGRPHRGPLDNARPAANGAASIASTRPAPSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5E8</accession>
    <name>A0A2S5B5E8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BMF94_5012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000063">
        <property type="protein sequence ID" value="POY72003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5E8"/>
    <dbReference type="OrthoDB" id="2528168at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="449"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="POY72003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="873" mass="94418" checksum="295BC2CCC5A3A2C4" modified="2018-07-18" version="1">MSTAQDAAEVLRISQRASTTCSECSRRKTRCDKQVPCDQIRQTIASTPLPPSVGLDNGVQASLGLPAPVYSQPSTSPDDHVRHPTPLPTMDSLAYGAYSEIAEIRTAIGNLQDRLQGLEGILAGVFGPAKQETTSPVLSMAYPPATNEAWFAGLPAGADLPVSTAPAEQDVLYSTSQPTGLAGPAFSPDRADPHLAYTPTDQALALPPLQAVPTSPPTTSAPHSRLPQTFSSTAVSSLPAEAEAVHDPRWAKLREEEVAASLSLEFLALGRNQQEPLAESATTVGGDAALSIRNIDNLVKHPLSVYPDAASLGPIVPPFSDCERIVDYTLERTSWLHACVHAPTFRAEVQQFWAIPHETRLHQTNPAWLSLFFAQICCGLRHSTRDQLDQLGPHGLSDQDVQILSKAHFDAAVACLYRSHPLENRQLHAVQAIAVLVIGCQDGALSNVFPSLLSLGIAMAQDLGLHRLPSDASWAKSVAALSPAERRRSLVLFETKKRIFWALTSEDWFSIHHRRMSTVQPTQVTTPLPSNAHDEDLMTGILIDRPPAEYTVTSKLLIWIQIARILQQAFQHLDDNPKPSYSFILELDQRMQALLDRMPQWLTSSSVALSPAAHLPPNAAWVRNAFIISSNHKILVLHRSFFLRHETSRRRAIDASRTSKRVRSDGDISNKLIIGEPVRSISAAASVICLDLFQRSSSNETLAEERAEVEVGLRTLQRMSSFSSIAKRGAALVQNLLQEEARLPPAADQRPGKRRRVSANLAGASAAQHSPSHGGLLGATALQSPPARSPGFLPTGLATPSPVGHSGSPRLTAPTSASIAQSSPNPSPHPYPSSLTDPLPAEFIAAFLKSEFDPLDGAITASQEDQSWPFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5Q3</accession>
    <name>A0A2S5B5Q3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5Q3"/>
    <dbReference type="STRING" id="741276.A0A2S5B5Q3"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02164">
        <property type="entry name" value="PPAT_CoAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000089">
        <property type="entry name" value="Bifunctional coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001985">
        <property type="entry name" value="PRK00777.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="2">
        <location>
            <begin position="191"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="374" mass="40316" checksum="00DB08176BB2E59E" modified="2018-07-18" version="1">MAYCVLSFGTLEQWYSLDWSDSAPTSSCRSTILTAAESSPDGLTIIVRVRDPDLNPWEPSVDAASSASSSSSAAPLDRQRRLGGPTRHFLALEQSLARLYSIATDSYVQRDLILATVDVVVEPLRRQPVCLPSHAPSFQWNYQEEAAVQADTQHGKGKVAASTNDHGPVPDLTSRSSDETAGPDRFPVVALGGTFDHLHAGHKILLTMAASLTTRKLIVGVTDDALLVNKKHRDLLEPLEVRTRHVERFVALVRPEIECACVPLQDVYGPTANDPEIEALVVSEETRAGGDAINKLRAEKSLGVLHVFCISLVADSAPPSSSPSSNPNSEDKAYSGTESAATTGQVLVSPATKMGSTGIREWLARRKGRGEDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5S2</accession>
    <name>A0A2S5B5S2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BMF94_4838</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000058">
        <property type="protein sequence ID" value="POY72106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B5S2"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1106"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1195"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1274"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1297"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1380"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="438"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="806"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1117"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1487"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1604"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1613"/>
            <end position="1623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="POY72106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1780" mass="195260" checksum="64762D2BE570E73B" modified="2018-07-18" version="1">MAQQLRFGTPAFVEAKADAWCRKEEGAAPWDGVDFDPCFRTRVFDGYIPLLFLVGSISCLLLRAFGAIVSRLRKRRIRDFKAVPKDAGPISRTSDGSRPIALAEARVLQHVAKVESPDWADPVTQKELLGSGHAAEMASYSATLASDLSLPYALGKAFLGCKKDLMAVALSCGTTGLGAWKLAIGYKRGEAGRAWVIFEVGGSAWGLVLALVKLAFGIQHRLYALRHPDAPHRGVAELYTALERHLIPWYIAYAALTAFVDLRSAVLERSEMPTREETEDVRVEAAIFGVSTALLLLEFFAPRPSRFSSRSKRSSAHQASAPRPTPPEMNASLFSLATFSHIDSFLMKSAFPKAYKAEPISAGNVPDLRPDDKTARVLLSYRQSVRKLDSRLARLPPFVRRLLLRDNKTIDDLGLTWKLVYHFWPMLVVQISWAVLPVLVNGIPPIMLNQILSAIAARQRGEHIPNHVLLLYAWITFLATVVVSIGRSMSLFLGRRICIRLRSIIVGEVFTKALRRKDQAGTSTVEESKDTPLKPTVEADSGETATPDGVSVPAIKLNGDAVEEADAAKELGAIEEELEKATSGKILNLISSDTYQLSEVCAYLHFITSEMPGTMIISIYLLYRLLGPSAFVAVAILLLLIPIQGKVSSLFNRYQHRLLAAADQRLALATEVIGQIRIVKFFAWEKSFLAKMDATRQKELAALWKRALTIVASTFMAFGAPIFVSVTVFTFHTKVLHRDLNAETAFTALVLLQILRAPLETIGDMLVHVLQAHVSLRRIDEYLHEQETQKYAVLADTSSSLLNTKVGFSKATFTWADEAHARDDATVFRLRDIDVEFPPGRLSIVLGPVGSGKSTLLLSLLGETNRLSGSAYLPSPVIRSTDHDPSLLTDTTAYAAQTPWLQSATIRENIVFGSLHNQRRYQAVLEACALVPDLAQFELGDETEVGEKGTVLSGGQKARISLARAIYSSAKVVLLDDVLSAVDSHTAQHLVEKCLRGKLMRHRTCILVTHAVDLCVPVAGFVVSLDQGNVVDACVPEGDDFRARLEAGRPDLHQVSESAFTIEELAGDEPDEIETADRRRRMEELKLVKDETRAEGSVKREVYATYIRAFGGWSILIAVLAVYGAAQLADIAVTLTLRYWAGSFDKRQASSAGLLITSASYAQTRIIPSRLHAFLSTSSVGILSGEPNLGKSPDYWLGMYCLAALVNIILVNARAAFFYWRGLKASSTLYSQLITRILGARTRFFDSTPSGRILNRLSRDVQVIDQDLPTSGMFWTYEILAALAIVVVISVNLPAFLLAAVLITLAYGFLGHLYVTSSRELKRLESVSKSPIFSVFAEALQGVATIRAYGDASRFMTNIFGLLDDNNRPFFTLWLANRWLSLRVDAFGGLVGLVATVFITYSPWIDAALAGFIMSFALSFQDRLLWVVRLIQANSVERIQECESTGEGQLCSPRSDAHMCLADLTVDQESQGGVSPPAIWPSRGGSISVNKLTASYAPELDPVLKGVSFEVRGGEKVGIVGRTGSGKSSLALSFFRFIEPSSGNITIDGLNINDLRLEDLRSRLTIVAQDAALFAGTLRFNLDPFDEHEDRDIWDALKRVQMAAPGASGITPRPTPRPTPGPSRAPSIKDGDSDTVAAADEDRFVVKTLDMQVTEGGKNFSAGQRQLLALARGILKLKSSSILILDESTASLDSATDERIQQTIRDEMADATILCIAHRLRTIIDYDKVLVLDHGVVLEYDSPTNLLSNEESSFAALCRKSGEWDVLKKMATDADAARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5U4</accession>
    <name>A0A2S5B5U4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prephenate/arogenate dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5U4"/>
    <dbReference type="STRING" id="741276.A0A2S5B5U4"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="459" mass="50724" checksum="DB265137BBAFE489" modified="2018-07-18" version="1">MAGQQPPSPPPIEDAVIGLIGMGEMGKMYAERLSKGGKCARINVCDLPERFEELQEYCKGKSKVVPMRDGHLVSRESDFIIYSVEAAYLDRVVAQYGSSTKVGAVVSGQTSVKAPERAAFERYLPADVNVVSIHSLHGPTVPSDGQALIVIKHRATDEQVQWVKDLLSPLNSRYVDLSYDEHDEVTANTQAVTHAAFLSMGTAWRCMGTFPWASGRYIGGIEVVKVNIALRIYAAKWHVYAGLAILNPTAQKQIHQFAQSATDLFKMMIQSREDELRERVYAARDFVFGRSGDSSSEDSATPILLSDSALDRFAIGNPSPTQPAAPPNSHLALLAMVDSWHQLRIRPFVHLALAATPVFRFWIGVAEYLFRDEDRLKAAIKAGGSAGSEGVAFSSDDAEFVIAARGWSDTVRYGSFDAYKQRFDETRAFFEPQFEESRVANRDMFAFLASEPIRTAVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B5V4</accession>
    <name>A0A2S5B5V4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000057">
        <property type="protein sequence ID" value="POY72173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B5V4"/>
    <dbReference type="OrthoDB" id="2524987at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="113" mass="11015" checksum="561C9271D04A8795" modified="2018-07-18" version="1">MESLNNVVEQAKELVGQYTGSTSTQSASSSTDAQPGSSGAPPVLEDAPDAVDGIGPTGGAALIEHEGVANADAPNVDQGAEYSATGRDATGTFDGGANDPPNLGAGVMPGRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B607</accession>
    <name>A0A2S5B607_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B607"/>
    <dbReference type="OrthoDB" id="2529685at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="284" mass="30636" checksum="D613C33F998E2EA7" modified="2018-07-18" version="1">MPSLPAGAAPPRSAVPLSPPSTSPNTATATNRTRTASRTRTDKKALLDALAEELKRARAEAELEAKRMIKVEDQVEAKHRDFLDEEIRLKAKRFANAATISNLRRDIARARQALDDAAHVDEAEAEAYLDLLQSSGSSPFSSDYGPGRPAELSREYERHAGALDRSDAARQPTIVAGYGYLAPASPPLTPGHERGPNDRLETLADRTAGTRERPTSPIGQHSRPSWQDGATPGLPASDYASPGTQPKPPVSPPQAGRDHAVPPLSRRWSRVLNGLNLTRTTSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B650</accession>
    <name>A0A2S5B650_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_4766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B650"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY72258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="201" mass="22341" checksum="4BCB58B629A4C486" modified="2018-07-18" version="1" fragment="single">RRRFGLPVWLGRSGVQIEQLRLDFGSRCRTGHRCRRRVHRVRCRRRRGALSVSTTLFACVVVPNESLQRGARRVSTGTGLVPLHAPPPPPTQPPFRLSSSTSLYMGFFIRFGFILPSPHRSCTFLVGMYGRSLVDVARLGGTHADESTMSASTGSTFVAYDRRGGADKQSRSRGDTVGERRARVKRLLAKLNNCTWPSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B652</accession>
    <name>A0A2S5B652_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B652"/>
    <dbReference type="STRING" id="741276.A0A2S5B652"/>
    <dbReference type="OrthoDB" id="2278929at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="578" mass="58834" checksum="300D5DAA9B4E2CC8" modified="2018-07-18" version="1">MAAQPRAIAPGPDSSRSTSFASSTAPPDSISLQTRPTAAPVIQGRPRDEVQHVLAGAHLSVGARDSDKAESRGGKRRRRERIPEERFLHVKRDELGWTRHLEERQWQLPHAQGCHNRLTSFDHLDADPNCNYQDNSVFTCYPESNTTLVQGDYSLVIWNAMQPSFINRQAVDVYLYNADTQDVATSWTNEPNAQGMIGIVPSDPWWPGPQSAQEWFGSAAQNRTTPYFFVVVPAGTSLTGGEVHGATFRAIQTAAPSSLSSTLAALTSSSLSSLSSVSQSSLSAASAASAASSRAASPSGSGTGKNGSLQNDSDSSPRVPNWGIALIVILGVLALVAGAAAVFLCLGRARKRKRAQAEAGETAAVGAGTAGATDRDYYDDDDLTQGSAEPILGGAAGSGVGAAAVSSSIGGASRMRSVGSGSSLAPALVGSAAGAGAGADLGALGARRRESHEGAIDQHDDGTTLSTSDAARMAEAFRAALRKSPFNLGGAASTTAAGGAAAGAGLAAAAADAGSGSSRPPGPSPTGAEKGDDSHGSSGDSSAIGIGAGRDLLVNELQGEGKSMKDVEGGGGKRWGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B653</accession>
    <name>A0A2S5B653_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BMF94_4755</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PJQD01000055">
        <property type="protein sequence ID" value="POY72249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B653"/>
    <dbReference type="STRING" id="741276.A0A2S5B653"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="162"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="432"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="593"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY72249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="709" mass="75613" checksum="D04EEFEA7771A72F" modified="2018-07-18" version="1">MDAFRTLTGGSRFDKKRFQSDMNHFQKQEPVASTSANAATNALPSELDFFGTSTATAAATPASAATKKDRKRKRASLAAAATASVSPTEGEDAAAPKVDSAALLRKHKIKLSGLDLPEPVSSIDDVVRRRSSHDGAEAVRRLAKNWRGLGYKDPTGVQMAAWGTMLAGRDILACAPTGSGKTYSFILPLLALLPPSLPAATSASDTVTRSAEDKVLRPRAVVIEPTRELSIQVLREARRLAFGPGGAAGEEGEEDATWKIAVLGEEGVGVQVKKKGKGKKGKGKAKEGAKAGEESAQAEVEQDKLGVHEEGEGADAEPEAYYGPVDILITTPLRLVFALKQNLVSLSSTRYLILDEADKLFELNFLEQTDEILAACASGRPEGGTEANEIRKGMFSATMPSTVEELAKGVMAGAGAGMVRAIVGHKEAATTTIDQALLFVNREDHKLLSLRSLITSGQFTPPVLIFVQSIQRAKELANELVFDGINADAIHADRSAAERDDVVRKFAEGKVWCLICTDVMARGVDFKGVKLVINYDFPQSAMSYIHRIGRTGRAGKAGKAITFFSKADAGHLKTIVNVMRASGCAVPDWMVALPNPSQNSKKQLKQRPIGRKDISRTLGAGALDDAEEGARTKAPREKGDKGQQNKRKGGPGKKERIMSGVGSGFAGAGGKARQQQQQQQKQSGAGKKDDKPAAERPAKKAKREVALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6D9</accession>
    <name>A0A2S5B6D9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000050">
        <property type="protein sequence ID" value="POY72353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6D9"/>
    <dbReference type="STRING" id="741276.A0A2S5B6D9"/>
    <dbReference type="OrthoDB" id="2529343at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="717"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="928" mass="96305" checksum="EE607B669FE1C16F" modified="2018-07-18" version="1">MAAERSETASEGLRRATRLATRRILAGPVAAAQPDRTSRNASALPSDSLVTRLRSRQSLANGAHTDEGSTRMFSQSSTPSVSQRSAAAEAGSATRIQTSVPTTRARRLTVHPAQQSQLPTAPTTTLSGPTEVAKPRNRARRLSRIEAGQMTGMGVVRAGPAVVGHRTPFKAAAVESAGPATAPRGGPSDPFSTAFVRPTYAFENPALGATAGAASSSLGYLAASSRQSQFSPSTSGGRFPTEAGAHPAAAVPTRSPIALLANARIAPHVPIDGSTESVFRILDETPVEYAPAASQPGSAPVSTGAPPSTVEPPLKSKRKRDATALDFQERENGAPIYFSPSKREHKRIHTVDSDESRDAAVNSDDVFGPVISSPAKSSSPARQIRSASSTGPEPAAIAAASSGGSQKSVPMQRTPGRTFGLPDLTNRPVPHSPRLFVSRAQLLNPSPSPARQDGIKTTERVVTASEQTVVAEKPAAESETRTGSPAHPPMWSLSLAPSSPIASAVTLSAPTNLILPTLSLFDPDRSARVELPAVEDDVSMSETADTSLASDTSQASTATSSRADETARRLANLQSMLSRLQAPKVAAAGTSALTGPSGRATSVGGLPSTTLSGRRTTFDSSTMPPPPVATNTARRAASVIRTGRPLGGSASAPSLHRGPQPPSSTAAASATRRRASLAASTVQQSENGGAPTGSASAGRLPLGSTSGAQPGAQRPARAKSCLKGVVAFVDVRTAEGDDSGMIFVDMLKDLGARVTVRPSSITTHIVYKAGKPTTLDFYRQLPLHRKPHLVGIAWVVQCAELNMRVEETKFKVEEVGTTLAPGRGKENADNVSATAQAALGLSGPAKDKASQVAIKRRRSMEPRALAALNNARANLSAANPDDSALKASIAASIERARRKSLQYAPRVGSPLAKRVFVMPDPVEEEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6M3</accession>
    <name>A0A2S5B6M3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000049">
        <property type="protein sequence ID" value="POY72395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6M3"/>
    <dbReference type="STRING" id="741276.A0A2S5B6M3"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="144" mass="15982" checksum="1FE4F57F307281A7" modified="2018-07-18" version="1">MTGPPAWPGTDYLYEQYRSETLSRSVLGERGGYDNGLTSPDSVNPEELATQSVRIKEEQLRREEEKLREVELRSQRELSEKRQELMAKEELLRNLEARLAAAQQQVNSATPPPPSPIGSGPASTYHDGYANGMPTAAHDSNGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6Q7</accession>
    <name>A0A2S5B6Q7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_4289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6Q7"/>
    <dbReference type="STRING" id="741276.A0A2S5B6Q7"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY72463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="283" mass="32043" checksum="7EA0DD2436A95B2F" modified="2018-07-18" version="1">MLRALRTLSSSRRLNTNAMAAEKVIFYDLVSTHEGPHPAAIPPNTWKGRLALLHKGVDFELKYLTFTELRAMAPKLGVERPVIPFIEFPDGKVISDSWNIAEWAEKEYPDKPSLWLPDAPAPVKEDDPTLKLAKNYAQTFAEGFAAWVPTFELSAVGIDALMPGTPETNPDKEYFRSDYKQRSKGAWQRLTSLDRDVVRERAKTALSPLEKVLAKSPFLCGDNSGFVDYVVYSRYAMMRSACPDECKSLWHGETTPNLSKWIERIETKFEAGLEEAFKRLPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B6V7</accession>
    <name>A0A2S5B6V7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4339</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B6V7"/>
    <dbReference type="STRING" id="741276.A0A2S5B6V7"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="577" mass="63255" checksum="4172723F14902523" modified="2018-07-18" version="1">MADSRQLSPTSTLHDGDNQQSSSFEKAKLAEQGANAPYDGQGSAESPYIVKWLDGEQANPQNWSKTKKWTITANSAISTLCIAFGSSIVSPAIPRLTTVFHKDLTVLTLSVSLYVLGFALGPLLWAPFSEQWGRRPIFIITYALFAIFNIPCAVAKNVETLLVCRFLAGFFGSSPLTNSGGVISDMFSASERALAVSLYAAAPFAGPVLGPIVGGFEVMNVKLEWLFWTLVIFSFVMLVSGSFNPETYSPVLLRRRAAKLEKETGKTYRSMYDLHPMFAAPFAVKMKAALIRPFLLLIKEPICLFFALYMSVVYGLLYCFFGAFPLVYEYARGWSPGVSGLAFIPVGLGMAGAIVANVFDNKRYVRKLIAGGGVPLAPEERLPLCCVAGVVLPLGLFAFAWTTLPHVHWIASMVFSVFFGFSMVAIFLSMLTYLVDAYLLMAASALAANAVLRSLVGFAFPLFTRQMFSKLGNQWALTLIAFLALIMAPIPFVFYRYGPAIRARSTFAPSHKPSPPAAPAAPAPASTDVSRTVTRTLTREEIEREEVAMMDLRQTESRREEEETLRKEGVDVPTARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7H9</accession>
    <name>A0A2S5B7H9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_4510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000048">
        <property type="protein sequence ID" value="POY72681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7H9"/>
    <dbReference type="STRING" id="741276.A0A2S5B7H9"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="486"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY72681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="598" mass="62015" checksum="05A6DF1E2C9836C9" modified="2018-07-18" version="1">MEQRQGTLMHSPALQSGHSDMYGLQSSVEAHERRKATEDLEAFLRTTLQQAQPSDRVPPQPPTFGGHVNGGGRPGPGSRKGSSFSARPPSVGSGSRTPVPQPSVLHAPQPRVPFHASPDWSYTNLPPVSTTSHHTGIVSTPSWTAVIPANSAGANTGSNVTSAMQASGLPSPAQMPPPPTTSGIHSTSYTYQHLQPSPSQGFALPPMNGADTSLASAATTFPFASTSTATMPSPSLPPNATIFSDLPSALSSAPPIGAPPAFFSSYGMYQPVVAPYPRFLTPSPEPSVLGDLELELGPSAGEFVPNGDGLDDVWKDLEERDGLNGPDGLVPIKKDPFEGMTLAQMRSRANSLEAVDRAAARYNPFASDAMVTSAAEEVKNAAQSMSMSVSPPSDDPGGTASSTSGPGKKGKRKANGANGGTAGLSKKNRAAGSAAASLAPSPENENDHPDGSRPALAGGGRKNRNPHSTQLPGPRRIGKIDPAEEGHEGPICSHCGSVTTPLWRRGPDDELLCNACGLYLKLHGKSRPKTFGKSGTPRRTSAGAAAQAASSGVPPSCNNCGATSTPMWRKDAEGNLCCNACSLYCESFVSFDLEKLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7S7</accession>
    <name>A0A2S5B7S7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_4228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7S7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7S7"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="64"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY72819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="308" mass="34283" checksum="1A1507D308A120B8" modified="2018-07-18" version="1">MFLTSSTTMAASRTPAVGRTLLSAPCSCSAPARLPRVRLQSTAAVESSGEASSSAGKANEAPSPRHRVVAAALLSRPPLLLPQLSPLERTYYAYQRRIHRALAKPFDVSSQWFFKKASQAEKAFTAFDQRAVEAEKHDDATGRKAFEMASEEVEGAPEFLERETEADKQGDVRSLERKQDRTLYLLLQKKRADHAWQFPQGGVEGTESLVDAAQRELLEETGPNVDVWPVGRVPAGAFSYPFPPAHKKKFPDFDSARVFFMPMRMIRGQAVPNQKEGIVDFAWLTKEEVKDKVSAEYWQAVEPILSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7S8</accession>
    <name>A0A2S5B7S8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_4237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000047">
        <property type="protein sequence ID" value="POY72828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7S8"/>
    <dbReference type="STRING" id="741276.A0A2S5B7S8"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="306" mass="33478" checksum="BF47CDE10832AACF" modified="2018-07-18" version="1">MVNPRQRRKRFSGTAKASASKRTLKNQKKVTIKGPEELVNGWDKNYAALGLLNSLDPRQSGGVEADLKAVPYATSHATAATVEDLDAILEDAEMDGSSSEDEDDNAQLTNGKGKGRAAEPVKEELKPGMARIIRDENGKVVKIVLAGEDGAEVEEQVIEPSRAAGGDDDEDDDEDDSDEEEAEPWGPAMKDWDAGPAQEKEFGSLEGVTKNSKQGIPIFGAPRRVEAKTDVVRALEERAARKTKVIRHTSEFEEVWLVKLVQKYGDDTAKMARDLKLNRWQKTPNELRKMIAKAGGVDTLKQAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B7X7</accession>
    <name>A0A2S5B7X7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B7X7"/>
    <dbReference type="STRING" id="741276.A0A2S5B7X7"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="181"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="670"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="810" mass="88346" checksum="71DEF9B9D630684B" modified="2018-07-18" version="1">MNLFAGFANPFAMPTAPSASSSSNHSAGGWSSSAAGSASTSSSLSPTPSSASSQSSFASCDSQLQPPAHLPSPDRTGDFDHDDSMTPIRFPPSSSAAFEPSSSTAAPLPPAVSPDLSIGAFDVLDVSEEEMADPVPQHAEQPSQTSFAQVQAAMAANNSSHSQNLIGQVLDASTATHVSHLEFVSVLGLGAYGVVYLARDIAAQPTPWPTSQAHPQLGNLPLYAVKCLNKVGLDARQRSFQRREIALHGLASAHPNVVTLHHVIEEESCIYVVLQFCEDGDLFGMITERQRYLGHDEMIRQVFLQIVDAVDFCHQNRIYHRDLKPENILCLDDGERVVLADFGLATHERTSGDFGCGSTFYMSPECQGGLFQRLSTYSTPHNDIWSLGVILVNLTCGRNPWKQACPSDETFCAYLGNPDFLRSILPISDHTNRILKRIFALNPQARISLADLRREILSVRRFTMTEEELQHATRATKEAAKAFAQSGGKGTPRAEQPVAVPQQRPAPQQPQQQRFDSNVVYVSDSDEDGDDEMMQDAAADEVVLPPVTVWSQAADESQFATPTQPSRKTPLTPPATPRRSTRSAHSPADPVRRSSPTPRRRRAEAPLTPPTQYRATFETLAAKNEPVQVPPTPATPTQRRRNSPSPPSRRSPRSARRPSPVTSRRRKTSVDSSSSSSDHSSSLSQPATPTTALYPNHHPNKVRIAGEDCPNTILRSRSAELDAELQLQASASNQSTLSVGTKAAYTAYYPIWSDDWADACRSQQADYHVELPPPVILPAEMDDHDEYEFPMPPRPTDGPVGYYTRVPARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B817</accession>
    <name>A0A2S5B817_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BMF94_4081</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000045">
        <property type="protein sequence ID" value="POY72920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B817"/>
    <dbReference type="STRING" id="741276.A0A2S5B817"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF55">
        <property type="entry name" value="SUGAR TRANSPORTER STL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="46"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="POY72920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="555" mass="60708" checksum="08A5904776C4DD0D" modified="2018-07-18" version="1">MASVDKKAPPPGVEKREFQHTSPAVSQDGTDLGTTNIPDKVHGVMVTVAASMGFCLFGYDQGVMSGLISAPQFFRTFPACDPARQGSYKASVLQAFYVAIYEIGCLAGAVFALMFGDRLGRRKMMFTGAIILIIGVVIQITAFSGHWAGGQFIIGRIITGLGTGFETSTIPTWHAECAKAHSRGFAVFIEAAMISTGTMIAYWIDFGFSYLDNSASWRVPIALQCIFAVALIALITFLPESPRWLVSKGHYVEAQKVIAALEPAPFNDEVVLLQLKVINDSLEGQTRQRKRDLITNGPTQHARRMLLGASSQFFQQVGGCNAVIYFSTPIFEEYLGLGRKLSLILGSVLATVYALSACISFPLVDKAGRRKLFFIGTWGQALSMFLIMACLIPGKDSSAINGAVVGIFLYLTFFGFTWLELPWLYPAEINPLKTRTTANAVSTINNWLFNFTVVMFTPPFLNSTSVGTFGFFAGINLCFLPVIYFFYPETAGRSLEEIDIIFARGYVEKVSYVKMAKIMPRLSGAEIEAEWRRLGLGDEERPTAGDGAEGFTAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B862</accession>
    <name>A0A2S5B862_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BMF94_4023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD1149</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B862"/>
    <dbReference type="STRING" id="741276.A0A2S5B862"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="164"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="POY72947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="672" mass="70386" checksum="E8B2E43CBF62E262" modified="2018-07-18" version="1">MVNQPALKIDVEAVNSQAAAQDGSLLPPDQTPSAGPTTTAAATPRTALNRRQSQKQPLQGDAVTTEQTTADGKDTFGVVNRHPVSVSAAAAVNNHDDDATQLSDEEPGFTVGVSVDRNKKCRRTMEECVDGCSPSLFLARRALTPFFFDPLAALTRSSTTLAVSVRKTSLEIGTLGDDEKIARTDAKLTAGGQGYFAVFDGHAGKHAAEWCGHHFHTHLLEHLRSAPSSTPVPDLLNATFLSVDAKLSELAVKGGTHSGCTAVTCFLRLEDDHGNPAGDASGVCNEVVPVKDEVAPPRVDKDAALKVARQLEEREAHDPTAFGNQGKRRDKDPLDPFDGGRDTTAEELKNLREDEEARTATEALTATTESATSSPAHSPRKKGDDGGKDLKRRIKAMLGVSGSSSSSASSSHDGSPAAGAGSDPEMPSSAISATSEGPTPVDGRSPNTLGSPGKAALPSSEEIKKRTSTLARSDSDDPTASLVPSTPSIPISAPAVSLPSEKATRRTLYTANVGDARAVLSRGGKAIRLTYDHKGSDAKEAKRISDAGGYVLNNRVNGVLAVTRSLGDSSMKEFVVGSPYTTETALGPHDDFLIVACDGLWDVCTDQEAVDLIADCADDAQAASQKLLDHALNNFSTDNLSVLVVSLHPPSKALARRRESTQDGGAGMIANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B868</accession>
    <name>A0A2S5B868_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_4031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000044">
        <property type="protein sequence ID" value="POY72955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B868"/>
    <dbReference type="STRING" id="741276.A0A2S5B868"/>
    <dbReference type="OrthoDB" id="2971022at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015565709" description="Phospholipase/carboxylesterase/thioesterase domain-containing protein" evidence="1">
        <location>
            <begin position="40"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY72955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="142" mass="15297" checksum="8C5943270FB13B4C" modified="2018-07-18" version="1" fragment="single">MHFVLPAPFIDPASWIPKGFLLALLLWALRHQVQRPAFGWDVWRDAQVPGGQVQVLGIGRHSASVVLIHGLGGNAAQLLEVVAKLRPELLQVAFVLPSAAPIALTARNGSKTSAWFDVDHFPTNRHAPLPTGPADIAGMIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8D5</accession>
    <name>A0A2S5B8D5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BMF94_3967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000043">
        <property type="protein sequence ID" value="POY72981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B8D5"/>
    <dbReference type="STRING" id="741276.A0A2S5B8D5"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="6">
        <location>
            <begin position="107"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="POY72981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="686" mass="75672" checksum="3A52EA8DA62899F3" modified="2018-07-18" version="1">MLPARRLGRGVGRQEDAVELAEQGALLSPRTHAEASGLLPRTKQPSPSTVDWRRGYPHQDGSRVAASKIGPQSRIYLLAGCLFGLACFIAVLVVPKVAPDTLAHVRDDAICASCLALIVPLQALARRGDEVFTRTIVGFCIELKIQDADICTGAVGLQAPILAHVLRSISSGSDAARMICASLVGVCPIPPIPRVQLKFTEPRSLPSVKRDSDPSSTSSADRGRIFQVAHMSDVHVDRKYMVNSSADCSKVICCRDYGPGSIGPQVLNEAGPCDSPPALADSMLQAIDTVAPDRAFTIFTGDAIDHAVWEDKRPRIEDDLRAWYQRYDSMSTPVYSVFGNHDGAPVNSFPTWSGTNEEPYWLYQDAASSWNRTIGSEAAAELAALSGCYSRVHPGTRLRIISVNTNYWYKQNFWLYDSDAIRWDPNGILTWLTRELDEAEQQQQRAWIIGHIPTGASDILMAQANYASQIYHRYRDTIAAHFYGHTHSDTFAIAYSDYSNRSAANAEGIAYVCGALTPMSGNPVFRVYDVHSESYEVMDFRIYRADYNDPQYQIEPNWSDPYYSARDSYGSYLDPPWPAEASLNATYWSLVVDAFERNDEAYELYNERLSRGLKAGPCSGECKRKVLCQLRTLSSEHNCGQSLNLTLSSRNETAELAQACTGPGLGSMLQAVGNSHMSEFAKALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B8P6</accession>
    <name>A0A2S5B8P6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 16">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BMF94_3780</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 16"/>
    <dbReference type="EMBL" id="PJQD01000039">
        <property type="protein sequence ID" value="POY73150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5B8P6"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 16" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="18">
        <location>
            <begin position="602"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="19">
        <location>
            <begin position="848"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1240"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1328"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1240"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1332"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1360"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1387"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1508"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1540"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1562"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="15">
        <location>
            <position position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="POY73150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1589" mass="175162" checksum="9D2C275BD4449DC1" modified="2018-07-18" version="1">MPRYADSDDDDNSVQSFGYDENESGSDVYDELPKKKTASTTKKATTKAAPKASTSKASTAKSTAVKKAAAAPKKKKQPLEERDTNGGGQSDADGGDSDVGMQDDDENDFVADKPAAAANKGKGKAKSASETYVKLTQLEHVLKRPDTYIGSVEPVTQPMWVYDQEIEKMVYRQTTFTPGFYKIFDEILVNAADNKVRDPTMSEIRVVIDPEKLTISVKNDGQGIPVEIHKKEGIYVPELIFGNLLTSSNYDDDEAKTTGGRNGYGAKLANIYSTEFIVETADAERAKKYKQVFSDNMSTKGKPKITDNKKGEQYTQITFTPDLKRFNMADGGFDRDTLSLLHKRVWDMAGIIPKVKVYLNGKVLRCKDFKAYVEKLLGGVNELTATGTKKKGKKDDGAVTAAVALFGGEDGDGPGGDDDDDLVKAAADGDASGKPTVIYERVNDRWDVAFSLSDGQFQQVSYCNSIATTKGGSHVNYVADQIVQGLVELVKKKHKNIVVKPFQIKNHIALFVNCKIDNPSFDSQTKENMTLTMKKFGSKCALSEQFLKKVAASGVIDNIVNWAKFKQDQALKKTDGHKRSRITGLVKLEDANNAGTRNGHKCTLILTEGDSAKALAVSGLAVVGRDNYGVFPLRGKLLNVREASGKALLENAEIQAIKQIMGLQQGKVYSSTDSLRYGSLMIMADQDHDGSHIKGLIINFLDYWFPSLLKLPNFLVEFITPIVKVTKAKKELSFFTIPEYEAWKEETHDGRGWKIKYFKGLGTSDARDAKKYFSDMNRHRLPFKELTIEDRALIDMAFNKKKADDRKEWLRGFVPGTYMNHDVDEVPISDFINKELILFSMADNVRSIPSVVDGFKPGQRKVLFGCFKRKLKNEIKASCAPRSLALTSVGQLSGYISEHSAYHHGDVSLQGTIIGLAQNFVGSNNLNVLDPNGQFGTRLQGGKDAASARYIFTNVAQITRSVFHADDDNILAYLNDDGQSIEPNWYIPVLPMVLVNGTDGIGTGWSSYIPNFNPSDIVANLRRKLAGEEMEPMHPWYRGFRGTIEKADKDGYKCSGIIERVDDSTVEITELPIRTWTQNYKEMLESWVAGTEKQTAWVKDYKEYHTDTTVHFIVTLTTAGKEAIEKDGLEKVFKIAGKVNTSNMVCFDPTGKIKKYASPEDIVSDFYDVRLDYYHRRKKHLVSELELVYDRLSNQARFILMIIKKELILASRKKAEIVAELRKRDFRPFPKVEKAHVAGDVDEANADADGEEEDARAQAGADSDYDYLLQMALSSLTSEKVEKLLSERDAREKELEILMGRSAQDLWRADLDAFSEQWEDLLAKDAADKARSLKKSKNPGKGKKRAANLSDDDDDFEVKPKKKAAPVKKAKPAVALPETDDDEKDSPAPGKAKPVAAKAAAAKPAAKAKAPAKRKQSVDLDLSGDEDDDGDKPTPPPAKKAKAAPKKAAASAKRTAVSDDEDDFDDLYALPTKKPAPHSPGSKRGGPAKAKAKAIEIDSDEDDEPVVPKKKAAAPKAKPAKKAAPVDSDLDFGDSPAPAPKARAARSTRAPAKSYKLTLGSDLDEDESFQIQNNDDDDEDAFELGDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9D3</accession>
    <name>A0A2S5B9D3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_3722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="PJQD01000038">
        <property type="protein sequence ID" value="POY73385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9D3"/>
    <dbReference type="STRING" id="741276.A0A2S5B9D3"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY73385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="516" mass="54786" checksum="16B487BE224952C3" modified="2018-07-18" version="1">MGLLSVPDFVSAANSPSPSSSSSTATSDSAMPTAVAVSARRGRTPRRKIFTEQDLAPWLRSSAYADLETTILRLTAAVEGKVNDAPCPESAPVRAVAGFLSKARGWIGRIPLAQGPQRFGNKAFRDWLAKVEEAEGPFQRSLLVKAGVNPSLAEDILPELSFHLLASFGSPQRLDYGTGHELSFVCYLVCLCRIRVFSEADEQALVTRVFKEYIDVCREVQKVFRLEPAGSKGVWGLDDHQHLVYLFGASQLTGHATLRPSSILSVAGVESLAPSYLFLSSISHIHELKCGPFHEHSPLLHQIATTVPSWTKVTKGLWDMYKVEVLGKVPVVQHCRFGEVGMRWTDTDSGEPLPSTGDGRADDEDAEDAPVLDGGPVITPAPWTRAEGTGSALGGGPVSPLTAAPRQLGASTTVSTQFSSAAHSRRQQPTTFPLAPASVRPTSFAPPPLFAPRGGAAGSTVQTRATVTSARAPPRDLATDAEGKRTVADLGGAAALSSPFGTLPAVGSGHQAERNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9S8</accession>
    <name>A0A2S5B9S8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9S8"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39005" checksum="7094858CD7992695" modified="2018-07-18" version="1">MSVKIEAADTNKALSAYLVGDLPSIRAKLCDAGVHKGFELHAVFHNKRFGIEWSNAHSDLYITQGTLEIKVDVWSEETNKESYASVEVRVCFEVAVHAPGSAASMAALIDCAALATLQQTQNDVRFVFPSPSKDLWASSSRLRTASSYFETLLSSSFEEGQMKLDADPMQAELVRQRDFDDSDDETDEIAEGSAVIAAATPTSAAAPHSTVRVSQTARATYAALLLWLATRTIDFAPLRSSGGSSRKEHIKEALQMRPTRPAPVSPKSVYRLAHLLDLEPLKSLALAKLTAELNVANAASELFSDVASSYPAIRDAALNFVVAKRAAVLASHGWRLAETRAGSGSLPPASVHTALLLARRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5B9Y3</accession>
    <name>A0A2S5B9Y3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_3468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000036">
        <property type="protein sequence ID" value="POY73531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5B9Y3"/>
    <dbReference type="STRING" id="741276.A0A2S5B9Y3"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="243"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="243"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY73531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="657" mass="69379" checksum="1B042FBC07C43C55" modified="2018-07-18" version="1">MAVRPPAHLVHWLPARPTRCTPPRHFLQPTPATMTAATSTRTGSRRLSTATRASGNAQPHLGTKRSLRSASDLADWLTGGARPQKRAFHASRTALAKNPYSVLGVGKDASTSEIKKIYYQLAKKYHPDSSKEPGAKEKFVEIQEAYDILSDDKKRADFDRFGSASQQPGFDSDAYARATSSFGGAGFGDFFGGGAGGPGGADIFESLFGAFGRGGAAGPRQQAVRGDDIEVSISVPFLQAAKGTTKTITISPVVDCHTCHGSGLKEGLQKTTCGSCGGSGTRTFTIQSGFQMASTCATCGGSGSVAPPGSNCGTCAGVGKVRERRTVEVKVPPGVDDGMRIRLDGKGDAPLNGGGRTGGTPGDLFVRINVQPSKVFTRQGSNLYQTVSVPFYTAILGGRAPVKTLDRDVEVRVPQGTQPGEEMVMRGRGVKKLYREDHGDLVVKFNVTMPRSLSPAQRAILQQYVQETEAPGSTPFSAGNFTPPSPSSSSSAERPAPDSSASTSSRVDADAPGFTQQSRPPPTDTETRGNKPQWWATMSDDITSTKPADAAAAAAASGAKGKQASGHEPEAGIEEKLEEAKEKFDEVAKEEVNNLERDAADAVKSAKEAATPASKSDPKDEKEDHTLLGDLWKAGKEKLKHAKDAVKCDGDKKDHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA37</accession>
    <name>A0A2S5BA37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_3124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA37"/>
    <dbReference type="OrthoDB" id="2803071at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY73591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="236" mass="26609" checksum="C2DE677EAE3F6B8F" modified="2018-07-18" version="1">MPAQEWQAEAVVNGVMVGNILVKLVVDELRYPGRLVNVPEQSAQERESSEMCAYARLQSLQGRHVLHCYGGFSFKMPWGNTVTGVLLEDLTGQSETLPGFIKRKLDQLQSVEQIDPLVRACFDLVHRVQAAGITAARLWADDFRVLEGSLVQTPFLCLSEFSVSSPTEEYEAFWLDFADPELGGPWQMSDEQTMLETLQSQFGDVLDDWWRGVLKEDAAYLHWSQHVLRVQEGACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA75</accession>
    <name>A0A2S5BA75_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA75"/>
    <dbReference type="STRING" id="741276.A0A2S5BA75"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="37"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="456" mass="51008" checksum="6B3D6C15F17467EF" modified="2018-07-18" version="1">MSEKEQDPPADFSTSIRDPRLKSQRKQAIKAVVMASILMSVAIWALLSVFWGSTYLLEHYFPNAKLYVYDFDSANNANPLLGPYVTQYMLSTLEQPTHMGVIIRDPTGKTIDDVITEIVQEKAWAAMVVNANASTMFREAIAGTGGLLNGEYAPAGALTVITEGARWFQVTDDYIFPFLTKYAQTPTLEASHAAAANFLATATPAQISGLSDTQRAALGTPFASQEYDPRPIFSHQWSGAAPLEAGLIYYIIFAFHIALFTFFARGPFMGSVAKKGRRLTFLSTLTLRFLPLLPIYLILSLSYSLINLAFLIPMNGNGHAKFGSQGGFMIFWMLNLMSLFALGFAMESMITLLTVKFIPFFLITWIILNITSSFFPATFAETFYRYGYAMPFWHSTTGAKHIMWGARDRLGLNFGVLTGWTVLNICSLTLFEFILRRKDQRKERKELSKDVEDHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BA99</accession>
    <name>A0A2S5BA99_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="13" type="ORF">BMF94_3186</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BA99"/>
    <dbReference type="STRING" id="741276.A0A2S5BA99"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015471902" description="UDP-N-acetylglucosamine transferase subunit ALG14" evidence="12">
        <location>
            <begin position="26"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="POY73651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="250" mass="27775" checksum="91AF93D3AB885C28" modified="2018-07-18" version="1">MPQAWDGRSAALAAAFLVCAVLALAVRSVNVVIKTHSGRRAPPRRDSSDEATLAVFLGSGGHTAEMMRLTAHLDWNRFTRRTWIISSGDSLSESKALALEKSIGSGEFRLLKIPRARRVHQSYLTSPFTTLYSLAFCLWHISLAPLLALNRERKPVFADLVLLNGPGSCVPIACATFLPRIVGLPSASLVYIESLARTRRLSLSAQLVRPLVDRFFVQWDSLRDELVKAEARKGERPRWKAKVECQGWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAA3</accession>
    <name>A0A2S5BAA3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAA3"/>
    <dbReference type="OrthoDB" id="2537480at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36332" checksum="F50A41447588DB18" modified="2018-07-18" version="1">MTRRYDRFHSSDSDDSDGSDDRERRDSSNADTDDGDVRDPRKTRTTSRKAGGNVFLLGVVFFLAIAACLGLAWYNFSPSAAAASSATSSPEAVSPTSAPEEVEAGLISASTPDQSEASSPPSSASQKSSPTSSPISKQSSPSAQSTSTAKPAPAGEGLVGYVDEKCGPSGAVAKSTKDKGPNGSEDWLNCGLSKDEPDAPWTPPSIKLDQVKTISLEVALAMDNSAYKACTKHVSLFEKYAEAYEVPPILLAAFAMQENHGSIKTGAAYFSQVLKEHDGSLLLAMGTYNGWYAGLTYNKATAARHTSCCECQNNLDYHHSMLNGWLLGLDGSQMGTIRNIECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAG8</accession>
    <name>A0A2S5BAG8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BMF94_3304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAG8"/>
    <dbReference type="STRING" id="741276.A0A2S5BAG8"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="10"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="POY73766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="283" mass="31523" checksum="BEB2F521D19E0C7D" modified="2018-07-18" version="1">MASNGTAGSPFFEIRAHPAGFLGAFATRPIPAGTLVLDDSPLFTLDAPLQAYLFQRAQAGGSGGPTPVEGEDEEDDEPAKDLDEFLERNIKTMLSWKTEDQRREFWDLANTRPDLPPAYGIFATNAVQTHGEIGGMFLMLSRFNSSCRPTLTRPAWDPTSHSTKLYALRDIEPGEECTWTYLNVTFEFEGVEARKEEMRQVFHFECCCVACDEANVTPAERAASEKRLLRLRRYKERIAGFSSGGGTDDDEGQRKRLLGEMAQLSREEGLWETAQRLDQAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAK3</accession>
    <name>A0A2S5BAK3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000035">
        <property type="protein sequence ID" value="POY73799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BAK3"/>
    <dbReference type="OrthoDB" id="2333993at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1546"/>
            <end position="1555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1555" mass="161953" checksum="5BB325388693B821" modified="2018-07-18" version="1">MGFREKIGLKKPRQSQSSEGSSTFLKDQGQRAESFALLDAVDLPKRVDQLYKYWVYEFLGVTPSTVRFDPSKFLLYDPQPLEAILKHRVDVHIVYPACRLPACFDEQDEAWIAATGSETTTAAKHEDERTYHAEAVIAGPCGFDTRGMSDSVQTRMFEWKVGQLSQDRETPWALSLTEIEPGLEGPSSELEWVLLNQPRPVRRKLDVPPFPASASRSLSRKSLSSNHPPTMSYFRLHGLHLDGQERCVVVSFSLEVSSESLAAEHGKRMAACEPQGRHVYIMRTIRSEFSDSTLLVIGHRLRTIIDFDKVLLLDKGRLIEYASPAKLLDDPTSRFYALCRATGKKEFAVLRRMSPSTSSAPPGPSSSARKPRGPTKRAAGTKASRAAAAAAAGLSDASSSVKASSVDLGGYDDVKPLMYDPATTGYVNTNDPDAPGYLAPDYTLNPAGPASNAEIDFKCPHCDKIYRGKHARSIWRRHLQDKHGIPLAAQPRRTRWDNDANRPKSEEEKRNRTLESKRRWARKNRAEKSSGTYSARKGRSSTQQPTPSFAGSDDDGDFGQLPDPNYVPLHHGTGTGYVDDEEGDSSFDTGSVGGWRAEGPPGLARGDSAPLGAYPSPHYGGAGAHLYGSPHYGHQFASASNPFYPHANLYGTGASTSAAASASAGGIGGRRTPTKAMDPYLAAIAAAAADQSRASLRASSSSAASGGPAGAGSAAALESGVRRSSRRAARTSYAEEDDDDEDEVEGEDTERERGLQQQQQQHRLPQLAYHSPIAGHSNPYSQPFHHYSQTQEPSHGPPLGHQQQYHHLAPPGYLSTSEGALSRPLSPSLISAAASAAANAQRTRTASGGSLFPTPYDMPGATPVSPGGSAPVAIPYYARRQSPARVITGSGIAAGIPAPTNGSDAHAAAVTAQGGLESPVKLRRTGSNGRGKEAIHRPNGGALASSGSGSGSAGLDGVGQGGPHREDAAGILLALKAGPSSPMASHVQSPVSSVRGSAATASAPLGRARRIPRRRIKGGNGDFADPDSADEHELGDGDDEDDEVERQQVQNMMLRPPPARPTDRPVSPWRAALQGQSQNLPAKGTAAEVAEAISPRKRGRSESPAPMLASTSSGEGGSAEAAHALLATAKKAHQYAAAGGAGAGTGPAWNSEMSLVATPTPGNMMRLGIESSPVVRFGGANGGGAGGAKALGGAHDEDEDDAIGDAGDSEGDMLGAARDGDDDEGELGRGGQDAFTSSSGGGRRSRRGASLGSSSQSDRRRRGNAGGSSSSGGGAGASSSSAARPLHHHHPVGLSSELGDFNLQPSSSSSGGRAHHHHDPLREDDAPMPGSSSSTKSNSHLVTPAPAATGLRRSVSANGPLPPPQAATHPHDPFLAAGSMAGATMLPLSSHALGNLARTSSPPGGFSSYLFSSPAHPQFSKTLGLTAAPGPGVMYTGVGGETPARGGSGSEGLAGSEIGGPHVGGSRVRELSGSNTSGDDDGKSLKTPVMGRILATSAGLIRRGGPATSVGMPASDVDSMGGEDESETTGTGRDESQSPGKATVDGDYDDDDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BAW6</accession>
    <name>A0A2S5BAW6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_3041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000033">
        <property type="protein sequence ID" value="POY73871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BAW6"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY73871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="344" mass="37341" checksum="85F1327695BC20F6" modified="2018-07-18" version="1">MHGLQLPRPMPREPPPATGPTASTSTAPVSVTATTSVIAGGLPHPVVKLPPKNFAEARSAARAIRGDRQKTPFVTRKSTAGKERDLSDLSVDQLATMLSRNAKLLDSPETFAKLPGGDARLRAQQRRIADRISELNAVSQIKHDLEATHLDGDEGPPPKDEDDQKPHVKKEEPDVAMDDEVLKPDEPKPAILGSTKMEEVVENGAADEATSPSAKRRIAAQILSRSPQSLTAGMTLAESIAIQQRAADRERREQDRKAARMRVAANRPQKTGELLRGALGVDSALSEYMFAADSDDSLDEADIDDYLNEGRKGVNGELNDEEDAQLNPLRTAYLEGWNRAEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBE5</accession>
    <name>A0A2S5BBE5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BMF94_2908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="741276.A0A2S5BBE5"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1248"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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    <feature type="region of interest" description="Disordered" evidence="4">
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    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="709"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="802"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="899"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="987"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1066"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1133"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1412"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1465"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="716"/>
            <end position="727"/>
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            <begin position="1069"/>
            <end position="1096"/>
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            <begin position="1135"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1185"/>
            <end position="1203"/>
        </location>
    </feature>
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        <location>
            <begin position="1414"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1424"/>
            <end position="1445"/>
        </location>
    </feature>
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        <location>
            <begin position="1484"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1499"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1522"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="POY74096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1539" mass="160646" checksum="99A78BDA5407D31B" modified="2018-07-18" version="1">MQTATGRSDRLWRETEADDSTERDGAGSNQGPGAASTSSAGATQQQPQPGTFLSRFLGNLRAASGGSGSRPALPRSLSSPVEFHSSDPASTLGTRSSKDGSPPKRASPPLQPGDRASAASPGNTNGSVGRRFKFRRSRTSLLEPESPEESPPTSPAAAFPVAVATPDSIPQPSPGSPATIRGKERNPIDAIYGGSAANSGSLDSTTGRPPVVNRRSSTKSQQTILAHDHPYAAGYAPGSPLGRIDEPAPQLRPHIDQSLELISTLLPPALLLLSQLGPTHLFSPPLQLPALFDVAMGASGYREGSISTATGSNAVLSSAASVKSNATASTCSASYFSELPTAAHVVASHSHELHAPNTLSIPAVSAAAFWRLFRGFEWIGEVGRGAQPLPPSVLSYSQGGEGGGPPVETEDEPEQVFDFPSLLQGVADILAADAAARGIELVVGQAGSGSAPSPAVTPSVAAASGQIPLGTRRRKDVETRELLVRADERAWSVTLVWILHHIIAGSMPGSTVEVRFVATAATPPHSPPASRPTTPPEPDLHGDLSTKPSRLQQWWNVSLEIEATAPDVATSPMASPQEPAPPPVTVPAPPFDTPFATSLFSLIQLVLTSTPFVDTSTRSWSLEALLPAARPEAPPELEDPDTLLGRRHIRLEPTAGQEPTINDLKRFADSALKGLKVALHAGENSAFARHLTVYLAGWGMDVQHVPIETDAGSGGSRSSEASQSRSSLIPPSAARFDSGFETATSSPAGSSDGKATEGPTGLDAPPSNLVIIDDDVSTLRRLLVSLRAPPLHYAPTLLAKRPQLSSRRARSTPHVRQAPPQNSPLQASQWVIIHFASLIDYKQIKEIVQDALATSRQPNLPEVLVVPKPAGPRRIMTAIWSALKRPLIDPTLPPIATSPSSPGVKYWTPRLSPSLSSKDREFDFSGAEDGITGKNGAGGSPSSVKARTPPTTHGHMTGSTMPPSPLGQVPDTADSYFCSVTEELKESTPSEGMVVQSPDGRSGIFFQPQPRARGSSFRERMRWVNSLERGPSSSVAQNIPEETPAQLRDSAPTATPMSVAAPHEIGLGSQSLSRRASNSISSRLASPADSAPSSGPLGTPALTLDAFISAAKSTSPLSSEIPTSDTTPTALVAEASGTRSPPSSRRSASGSSVGGAPVPALARSAPVAASPSHPSRQNSGNSIVAPESAPASSSAAAEGAAAALQTKSPPTGALGSKPRSKPCSTTAMPRTRRRSSRRGTLPAVPPISVLIVEDNPINQTILSVFMRKKGITYKVAKDGQQAVDMWKKGNFHLVLMDIQLPVKSGIEATREIREMERLNNVSMLVTTPTSDIGSPVSSSSSNPLSTPNSPILNMPVIIVALTASSLQADRVAALAAGCNDFLTKPVSLPWLESKLVEWGSMAYLSGFSRRSDVSSDATSVSSAPNSRSGTPSKSRSRPQTPNTYSKGFANRADVVSQHLHIERPISRAPSPSGHPVSPHPIMPPSALSPDSPDPVSLSEQQQSVQAQAKPSLQVTSPTPQRTSSAAAVSVATPAESAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBF9</accession>
    <name>A0A2S5BBF9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BMF94_2916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBF9"/>
    <dbReference type="OrthoDB" id="2526511at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="670"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <begin position="782"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="940"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
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    </feature>
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            <begin position="105"/>
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            <begin position="134"/>
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        <location>
            <begin position="160"/>
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        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
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        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="417"/>
            <end position="431"/>
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        <location>
            <begin position="551"/>
            <end position="560"/>
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            <begin position="582"/>
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        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
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        <location>
            <begin position="727"/>
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        <location>
            <begin position="811"/>
            <end position="823"/>
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        <location>
            <begin position="856"/>
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        <location>
            <begin position="868"/>
            <end position="877"/>
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        <location>
            <begin position="940"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="POY74104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="1013" mass="107565" checksum="E920402736884E97" modified="2018-07-18" version="1">MGSRDWATVGQSFATPPVASSSRSAAAASSHSRGGKARPARKSDSHSTQARLFALDKAPLVTPRPAASAPRPLQKQAKLDAFTTSEASHSGRKSKLKRRSTLGGPERERGNVLDRDSPPDASTSTRKHAAFEVYPDRSTPEGAEPRRRVKVEQSLEPDQPDARFRDIFRRAAKPGNAARSSSPSSAARSGTAPTSGIGRAILAKPTRRGPSIEFDRDLANDLSPSQEMLGEADRKKRRRIESSAASWGKLEMCDVDDHDGFGSPDKRRRSANRGSSVAGTARGTQRVPVLEPEGDVKPPVGRANSSARRAVAPSQARYPVPPSPRAPSPRKRSRITPPASPVCLCPPTPSPTSSGSSNESTSRTAAALQAHLVPSRVPAWNGGQPAISNAEPILLVPESDPPEPPLEDGEEEPEPSTVDSSAERQASTPVASTPRPLKELSLSRVSDAAAPVTVAGPQRARRGDDSGFSEGGAVLASDDATPKAPLKRNLSKIDLTTLPTSSPTVTGGRRPMREDDMLDVVEIKRDGHAGGELGRTASGVLMPPPPLPVSPKKRPGRLRRGAPSTRAAATAEAEAVKAESLAQRSSSKDTSPTETLLDETQPSKGEGTAQIGLDDSYPWLFADMPRPNAAKGYTPIRFGALDHLRLPTPHPKDSPRVGPAAAAQSSPIRAPAEAVEDLLEPETVLPASPPHEKALSLLDKSVSGWTDAVAPAWAGARPPSPNAPRQAHLDDFFSRIRNTQHDDDGGRPESLVVEDSQAPDVDLADLALQRAMLQTRARMEQFRASMPNGREALGSAGDGQLAAVERVADNARSSSEPHVTPTKSNERRASARTPQSTQSVEDSDPEDDALAIPSACNRTRGGSTSPTKDARRGRDGKGSSSPLGAPVRNRFPRYSPSKLKRAMDRYGSPPDGDRSPRLVDAARRGAAAVPLPVGGETQWESYWSYPSQPGSAAGGHDEAPEPSPTCLQAILDKLEATAPALPEGWTRNEAGELVRLDADKWDPERASLEESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBH0</accession>
    <name>A0A2S5BBH0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="PJQD01000029">
        <property type="protein sequence ID" value="POY74098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBH0"/>
    <dbReference type="STRING" id="741276.A0A2S5BBH0"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="429" mass="46432" checksum="3649E096137EC2A5" modified="2018-07-18" version="1">MSTFGTLFRVTTFGESHCASVGAIIDGCPPGMPLSDEDIQPQMTRRRPGQSVLTTPVSLAPASNEARILTRKWLLVQRNEQDAVQIQSGVEAGYTLGTPIGLMVKNKDHRPHDYTETDDYPRPSHADWTYLLKYGIKASSGGGRSSARETIGRVAAGTIAERYLKMAYGVEIVAFVSSVGKIHIPDSNGDDDLLSEDYLKLLHGLTREKVDENTVRCPHQETAELMEERIHEAKANNDSIGGTVTCVIRQSPVGLGEPVFDKLEAKLAHAMLSIPATKAFEIGSGFKGCEMPGSLHNDAFVQKPDGRLGTKTNRSGGIQGGITNGEDIYFKIAFKSPATISQEQSTATYAGKSGVLATRGRHDPCVVPRAVPIVEAMAALVIMDAVLIQNSRKMAASLLPELNLPPSMALPPKKVQDEMVKKIVDQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBQ9</accession>
    <name>A0A2S5BBQ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BMF94_2745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000028">
        <property type="protein sequence ID" value="POY74171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBQ9"/>
    <dbReference type="STRING" id="741276.A0A2S5BBQ9"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="337"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="POY74171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="600" mass="67124" checksum="F019283A334D1649" modified="2018-07-18" version="1">MQRPRARGGAAAAATTAALARRIFQQKFSLQLAPGVIDWLETFVKHFEMEGDEEQITTTFEHLVRGCIGSGSGLDGPSKITVPLLEETYEKLLVAADPDADAGGKGNGEDLDASQYFKIVDSFDLPAWRWDDIRGGFEKPKTPPTLAPGPFSKSRYLRDRFNVIKQVILRNEHFCPPTVVDAARANYMKLTTIKNLLGRQGGHFLLFGLLTRMEDNEFYLEDLDDKVKLDLRDATPESGLFTEGSFVLVDGDYGYDSVFKVAEIGHPPSERRDEAMKIHGHHDFLGVGVISASEEVCAQASRASGNVWESASAETFDTPTQADLIAAEQSPSHETSFIMLSDLHLDNPRVLNALRQVLSAYDSMEDEKSVPKLFVLCGNFRSRPWLFNGEAMREYTELFASLATLLSSFETLLAVSHFLLIPGPTDPWSSAALPRPALPAALLKPLLSKVPNVTLGSNPCRIRWFSQEIVVFRDDLMGRMMRNAVRFPAQEGEEDGGGKKTDLRKALVQTVLDQAHLAPLPLTVRPVLWDYDHALRLYPMPTTLVLADSFEPYKLVYERCLVFNPGSFNRRRFGWSTYHPHMTEIKDRMEESELPDPSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBT7</accession>
    <name>A0A2S5BBT7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BMF94_2665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD1149</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBT7"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="POY74227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="296" mass="32855" checksum="1B8688EAA4CE0DF6" modified="2018-07-18" version="1">MTELNASYSLAPFTVRDGAMWTMPEEAVPNRVVTAIKSAGRRVQHARLSTGPLFTNGEPLAQLNRLIALLPECETLELQYDTSIDIFAQYTSTNLEAWMKAIGNLKKLTRLSTNGFEKWDATLCFMGIALPPKLSDFAAQRCSVSVFAIEALGKECGATLVSLSLADLEWPLRLQWQECEGPFHFPALRRLVLWTEVAAGFMDAFKLAPLEHVVLARESHVEGFSFTFDFQGRQHCEHDVEGIDRLCAQHTATLRTVRIHQDHLTSGHEQLEPYLGNHGLAGALFSGATPAFPDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BBV1</accession>
    <name>A0A2S5BBV1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BMF94_2676</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000026">
        <property type="protein sequence ID" value="POY74238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BBV1"/>
    <dbReference type="STRING" id="741276.A0A2S5BBV1"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="354"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="554"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="POY74238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="596" mass="64556" checksum="119EDADE2F3012C0" modified="2018-07-18" version="1">MAGEKRDASPSASTAQVETPSKRQKLDDKPGEPAAAPAASAIAPSNAAATSADGDAPSSPAPVARETDSPSSRGKQRGGRGGGRGGSFGDRRSRNERSAAGKHAAKGRGRDRNDEAREGSRNAETAAKAAAGDAAGANAAANDEDKRDKLPKKKVALLIGYSGLGYKGSQINPDTETIEGEVFKALVAAGCISEDNSKDPHKVSLARAARTDAGVHAAVNVLTLKLILTPPSKAAETSIEDHINAFLPAGIRVWSILRVQGSFDPRRVCDQRQYEYTLPTHVLLGPKPGTPMYETIEKGRNADSAFDATKFPIIEASQKFWATQPEKSDFLADVQAKKGWRMPSEVLGQLRDFVQAYEGSHNFYNFTVGKDFRDRSCQRVMRKLEISEPFVVNDTEYVSVTFIGQSFMLHQIRKMIGLVMIAVRSATPPSLIPETFGPSRIHVPKAPGLGLLLISPHYTEYNKRIAEGNAKLDELVAAGRMDDKAYGEQKRDAIDFVELGLSERIDAFKQEQVYKRMWSVEEDELVFSKWLNFLDTFVSNDFDYLNPKGVIPASATYKKGENPERTRAASTNGVRAPDAEAAAPSDDEDGIGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BC15</accession>
    <name>A0A2S5BC15_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2508</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BC15"/>
    <dbReference type="STRING" id="741276.A0A2S5BC15"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="140"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="453" mass="51464" checksum="D0CAF5DFC5CF5BB2" modified="2018-07-18" version="1">MVANGTTAKRRKPSAASQAAAATEPTEPETVVDFVLRRQLELSGGILAAIVVANAFTNPDLHVSTDLTPDPAFHFRSIPARFLHLSFRQPGTDLYFKGRDDGFLIAWWVIAFCFLREATMRWGLRPLARWSGIRSSRAVVRFAEQGWLLVYYSFSWSIGIYINQTSPYRNLNTSEFFKGYPHIALTALTKWYYLVQTAFYLQQILVINLEARRKDYYQMFAHHIITSLLMMSSYVLNWTRIGSAILCTMDLVDITLPLAKLFNYAGWQAASDVTFAVFFLLWIVTRHVIFGRIIWSIIAEAPTILPFGWSSREGYFWSKRTYWAFIGLLGMLQLIICLWFAMILRVLWNMFRGHSAEDTRSDDEDENDLDPSETEDETDATTCDDDDETTASELESSVASLPRNGGETRNGGGAGVRRRRQVAGAVTERIPEFGGANEHAAMDPVRREKAPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCB3</accession>
    <name>A0A2S5BCB3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BMF94_2613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD1149</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCB3"/>
    <dbReference type="STRING" id="741276.A0A2S5BCB3"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="271"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="407"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="POY74419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="472" mass="52343" checksum="64AC18EFEEAFE682" modified="2018-07-18" version="1">MSAAQTNGDFSIKPESTTPQLDTKDWPLLLKNYDKLLVRSAHFTPIPAGSSPLKRDLKSYVKLGVINLDKPSNPSSHEVVAWIRRILRCEKTGHSGTLDPKVTGCLTVCIDRATRLVKSQQGAGKEYVCVLRLHGALDSEKQLGRAIETLTGALFQRPPLISAVKRQLRIRTIYDCKLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGLLLGVGGHMQELRRVRSGAMSESDDIVTMHDVLDAQWVYDNTRDEQYLRRVIRPLESLLTGYKRIVVKDSAVNAICYGAKLMIPGLLRYEADIELNEEVVLMTTKGEAIAIGIAQMSTVELSTCDHGVVAKIKRCIMDRDTYPRKWGMGPIAMSKKKLKSDGKLDKHGRTNDQTPAEWKTAYVDYSVQGEGLPAQQIPTQPTAAAAPQEPVAVPVAAGSSEEKLVEQTKVDGEVKEKKRKREGETAEERAARKAAKKSRKSDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCF6</accession>
    <name>A0A2S5BCF6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BMF94_2636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhodotorula taiwanensis</name>
        <dbReference type="NCBI Taxonomy" id="741276"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Sporidiobolales</taxon>
            <taxon>Sporidiobolaceae</taxon>
            <taxon>Rhodotorula</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Front. Microbiol." volume="8" first="2528" last="2528">
            <title>Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.</title>
            <authorList>
                <person name="Tkavc R."/>
                <person name="Matrosova V.Y."/>
                <person name="Grichenko O.E."/>
                <person name="Gostincar C."/>
                <person name="Volpe R.P."/>
                <person name="Klimenkova P."/>
                <person name="Gaidamakova E.K."/>
                <person name="Zhou C.E."/>
                <person name="Stewart B.J."/>
                <person name="Lyman M.G."/>
                <person name="Malfatti S.A."/>
                <person name="Rubinfeld B."/>
                <person name="Courtot M."/>
                <person name="Singh J."/>
                <person name="Dalgard C.L."/>
                <person name="Hamilton T."/>
                <person name="Frey K.G."/>
                <person name="Gunde-Cimerman N."/>
                <person name="Dugan L."/>
                <person name="Daly M.J."/>
            </authorList>
            <dbReference type="PubMed" id="29375494"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD1149</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="PJQD01000025">
        <property type="protein sequence ID" value="POY74442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2S5BCF6"/>
    <dbReference type="STRING" id="741276.A0A2S5BCF6"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000237144">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="POY74442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000237144"/>
        </source>
    </evidence>
    <sequence length="274" mass="30454" checksum="69CD621638E8FF86" modified="2018-07-18" version="1">MVRHYKLPAMNTPARKPRPTHGAQPIRLQPRSRWTLRNLLLSGLVLGALSALVGVLEQVKSRWYIFNPADMHKLCQDALALHGNDTVSVVSHIVTSLSQSHPSSAINTAFFSTPLLSSPVNGSVLPESYSPNDREWVWNNAGGAMGTMFIIHASITEYLIVFGTPLGTEGHTGRHTADDYFHIISGEQWAAKAGAFELERYVAGDVHHLVRGEIKQYKFHEGGFAIELAQGWIPLMLPFGFADTFFSTLDFPTLYHTIRITGREMIKNLLHGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2S5BCJ0</accession>
    <name>A0A2S5BCJ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid transaminase</fullName>
        </recommendedName>
    </protein>
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